editor preferred label
type: AnnotationProperty
editor preferred label: editor preferred label
editor preferred label: editor preferred term
editor preferred label: editor preferred term~editor preferred label
has curation status: IAO_0000122
textual definition: The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English)
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
label: editor preferred term
label: editor preferred term~editor preferred label

has curation status
type: AnnotationProperty
editor preferred label: has curation status
definition editor: PERSON:Alan Ruttenberg
definition editor: PERSON:Bill Bug
definition editor: PERSON:Melanie Courtot
definition source: OBI_0000281

textual definition
type: AnnotationProperty
editor preferred label: definition
editor preferred label: textual definition
has curation status: IAO_0000122
textual definition: A property representing the English language definitions of what NCI means by the concept. They may also include information about the definition's source and attribution in a form that can easily be interpreted by software.
textual definition: The official OBI definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.
textual definition: The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.
editor note: 2012-04-05: Barry Smith The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. Can you fix to something like: A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. Alan Ruttenberg Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. On the specifics of the proposed definition: We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
has exact synonym: DEFINITION
label: definition

editor note
type: AnnotationProperty
editor preferred label: editor note
has curation status: IAO_0000122
textual definition: An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology.
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obfoundry.org/obo/obi>
database_cross_reference: IAO:0000116
has_obo_namespace: uberon
id: editor_note
is metadata tag: 1
shorthand: editor_note

definition editor
type: AnnotationProperty
editor preferred label: term editor
has curation status: IAO_0000122
textual definition: Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people
editor note: 20110707, MC: label update to term editor and definition modified accordingly. See http://code.google.com/p/information-artifact-ontology/issues/detail?id=115.
editor note: 20110707, MC: label update to term editor and definition modified accordingly. See https://github.com/information-artifact-ontology/IAO/issues/115.
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
label: term editor

alternative term
type: AnnotationProperty
editor preferred label: alternative term
has curation status: IAO_0000125
textual definition: An alternative name for a class or property which means the same thing as the preferred name (semantically equivalent)
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>

definition source
type: AnnotationProperty
editor preferred label: definition source
has curation status: IAO_0000122
textual definition: formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007
definition editor: PERSON:Daniel Schober
definition source: Discussion on obo-discuss mailing-list, see http://bit.ly/hgm99w
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>

imported from
type: AnnotationProperty

Has_NICHD_Parent
type: AnnotationProperty
textual definition: An association created to allow the source NICHD to assign a parent to each concept with the intent of creating a hierarchy that includes only terms in which they are a contributing source.
code: A11
Semantic_Type: Conceptual Entity
Preferred_Name: Has_NICHD_Parent
has exact synonym: Has_NICHD_Parent

Related_To_Genetic_Biomarker
type: AnnotationProperty
textual definition: An association that indicates that a finding or lab test is related to a gene, possibly through a variant or product.
code: A13
Semantic_Type: Conceptual Entity
Preferred_Name: Related_To_Genetic_Biomarker
has exact synonym: Related_To_Genetic_Biomarker

Has_Target
type: AnnotationProperty
textual definition: An association that connects a drug or other agent to a clinically intended, molecular-scale target. The target value may be a gene, gene product, anatomic structure, biological process, or other concept, where the effect of the agent on the target is thought to be of therapeutic, diagnostic, or other clinical relevance to a disease process. The effect is most often direct, as defined at a molecular scale, but may also be indirect and/or defined at a larger scale.
code: A7
Semantic_Type: Conceptual Entity
Display_Name: Has Target
Preferred_Name: Has_Target
has exact synonym: Has_Target

code
type: AnnotationProperty
read only: true
textual definition: A property representing a concept unique identifier within the NCI Enterprise Vocabulary Service's NCI Thesaurus.
code: NHC0
Preferred_Name: code
has exact synonym: code

Semantic_Type
type: AnnotationProperty
textual definition: A property that represents a description of the sort of thing or category to which a concept belongs in the context of the UMLS semantic network.
code: P106
Semantic_Type: Conceptual Entity
Display_Name: Semantic Type
Preferred_Name: Semantic_Type
DesignNote: In general, applying semantic types aids in allowing users (or computer programs) to draw conclusions about concepts by virtue of the categories to which they have been assigned. We use a set of semantic types developed for the UMLS Metathesaurus. There are currently 134 semantic types in the UMLS.
has exact synonym: Semantic_Type

Display_Name
type: AnnotationProperty
textual definition: A property representing an alternative Preferred Name for use in some NCI systems.
code: P107
Semantic_Type: Conceptual Entity
Display_Name: Display Name
Preferred_Name: Display_Name
has exact synonym: Display Name
has exact synonym: Display_Name

Preferred_Name
type: AnnotationProperty
textual definition: A property representing the word or phrase that NCI uses by preference to refer to the concept.
code: P108
Semantic_Type: Conceptual Entity
Display_Name: Preferred Name
Preferred_Name: Preferred_Name
has exact synonym: Preferred Name
has exact synonym: Preferred Term
has exact synonym: Preferred_Name

UMLS_CUI
type: AnnotationProperty
textual definition: A property representing the concept unique identifier (CUI) assigned by the National Library of Medicine (NLM). If a concept in any NCI-maintained knowledgebase exists in the NLM Unified Medical Language System (UMLS), NCI includes the NLM CUI among the information we provide about the concept.
code: P207
Semantic_Type: Conceptual Entity
Display_Name: UMLS CUI
Preferred_Name: UMLS_CUI
has exact synonym: UMLS_CUI

NCI_META_CUI
type: AnnotationProperty
textual definition: A property representing the concept unique identifier (CUI) for those concepts that appear in NCI Metathesaurus but not in the National Library of Medicine Unified Medical Language System (NLM UMLS).
code: P208
Semantic_Type: Conceptual Entity
Display_Name: NCI Metathesaurus CUI
Preferred_Name: NCI_META_CUI
has exact synonym: NCI_META_CUI

CAS_Registry
type: AnnotationProperty
textual definition: A property representing the Chemical Abstracts Service number for a Chemical or Drug.
code: P210
Semantic_Type: Conceptual Entity
Display_Name: CAS Registry Number
Preferred_Name: CAS_Registry
has exact synonym: CAS_Registry

Accepted_Therapeutic_Use_For
type: AnnotationProperty
textual definition: A property representing a disease or condition for which this drug is an accepted treatment. Used in the Drug, Food, Chemical or Biomedical Material branch.
code: P302
Semantic_Type: Conceptual Entity
Display_Name: Accepted Therapeutic Use For
Preferred_Name: Accepted_Therapeutic_Use_For
has exact synonym: Accepted_Therapeutic_Use_For

Concept_Status
type: AnnotationProperty
textual definition: A property used to indicate the standing of a concept in relation to currently accepted classifications and concepts. In NCI Thesaurus concept status subtype indicates concepts with unusual and problematic characteristics that should be evaluated by people and/or programs before those concept are used.
code: P310
Semantic_Type: Conceptual Entity
Display_Name: Concept Status
Preferred_Name: Concept_Status
has exact synonym: Concept_Status

SNP_ID
type: AnnotationProperty
textual definition: A property representing the dbSNP id number for the genetic polymorphism due to base substitutions.
code: P315
Semantic_Type: Conceptual Entity
Display_Name: SNP ID
Preferred_Name: SNP_ID
has exact synonym: SNP_ID

FDA_UNII_Code
type: AnnotationProperty
textual definition: A property representing the FDA Unique Ingredient Identifier, a key component of the federal drug information model.
code: P319
Semantic_Type: Conceptual Entity
Display_Name: FDA UNII Code
Preferred_Name: FDA_UNII_Code
has exact synonym: FDA_UNII_Code

Contributing_Source
type: AnnotationProperty
textual definition: A property is used to indicate when a non-EVS entity has contributed to, and has a stake in, a concept. This is used where such entities, within or outside NCI, have indicated the need to be able to track their own concepts. A single concept can have multiple instances of this property if multiple entities have such a defined stake.
code: P322
Semantic_Type: Conceptual Entity
Display_Name: Contributing Source
Preferred_Name: Contributing_Source
has exact synonym: Contributing_Source

ALT_DEFINITION
type: AnnotationProperty
textual definition: A property representing the English language definition of a concept from a source other than NCI.
code: P325
Semantic_Type: Conceptual Entity
Display_Name: [source] Definition
Preferred_Name: ALT_DEFINITION
has exact synonym: ALT_DEFINITION

PDQ_Open_Trial_Search_ID
type: AnnotationProperty
textual definition: A property representing the identifier used by NCI's Cancer.gov Web site to retrieve PDQ Clinical Trials data for open trials involving specific clinical trials agents. While the identifier is the same for both open and closed trials two properties are used to support requirements of the current browser interface, as well as the possibility of providing values where only open trials will be retrieved.
code: P329
Semantic_Type: Conceptual Entity
Display_Name: PDQ Open Trial Search ID
Preferred_Name: PDQ_Open_Trial_Search_ID
has exact synonym: PDQ_Open_Trial_Search_ID

PDQ_Closed_Trial_Search_ID
type: AnnotationProperty
textual definition: A property representing the identifier used by NCI's Cancer.gov web site to retrieve PDQ Clinical Trials data for closed trials that involved specific clinical trials agents. While the identifier is the same for both open and closed trials two properties are used to support requirements of the current browser interface, as well as the possibility of providing values where only closed trials will be retrieved.
code: P330
Semantic_Type: Conceptual Entity
Display_Name: PDQ Closed Trial Search ID
Preferred_Name: PDQ_Closed_Trial_Search_ID
has exact synonym: PDQ_Closed_Trial_Search_ID

Chemical_Formula
type: AnnotationProperty
textual definition: A property representing a concise expression about the atoms that constitute a particular chemical compound.
code: P350
Semantic_Type: Conceptual Entity
Display_Name: Chemical Formula
Preferred_Name: Chemical_Formula
Contributing_Source: CRCH
has exact synonym: Chemical Formula
has exact synonym: Chemical_Formula

Legacy_Concept_Name
type: AnnotationProperty
read only: true
textual definition: A property representing a retired unique concept identifier created and stored as Concept Name by legacy EVS software. Use of these values was long discouraged, but continued as late as 2009 when creation of new values ceased and Concept Name was retired. Legacy values are intended solely to help resolve and update earlier coding.
code: P366
Semantic_Type: Conceptual Entity
Preferred_Name: Legacy Concept Name
has exact synonym: Legacy Concept Name

CHEBI_ID
type: AnnotationProperty
textual definition: A property representing that a concept in the 'Drug, Food, Chemical or Biomedical Material' branch of the NCI thesaurus maps to a specific concept in the EBI Chemical Entities of Biological Interest (CHEBI) database.
code: P368
Semantic_Type: Conceptual Entity
Preferred_Name: CHEBI_ID
has exact synonym: CHEBI_ID

NICHD_Hierarchy_Term
type: AnnotationProperty
textual definition: A property representing a term chosen by NICHD to be used in the representation of the NICHD hierarchy.
code: P371
Semantic_Type: Conceptual Entity
Preferred_Name: NICHD_Hierarchy_Term
Contributing_Source: NICHD
has exact synonym: NICHD_Hierarchy_Term

Maps_To
type: AnnotationProperty
textual definition: A property representing that a term in another terminology has been mapped to a term in NCIt and describes the relationship between the mapped terms.
code: P375
Semantic_Type: Conceptual Entity
Preferred_Name: Maps_To
has exact synonym: Maps_To

DesignNote
type: AnnotationProperty
textual definition: A property representing notations made by NCI vocabulary curators. They are intended to provide supplemental, unstructured information to the user or additional insight about the concept.
code: P98
Semantic_Type: Conceptual Entity
Display_Name: DesignNote
Preferred_Name: DesignNote
has exact synonym: DesignNote

Chinese translation
type: AnnotationProperty
definition editor: YH, JX
comment: a chinese translation represents a chinese translation of the existing term.

has_MedDRA_id
type: AnnotationProperty

IEDB alternative term
type: AnnotationProperty
textual definition: An alternative term used by the IEDB.

created_by
type: AnnotationProperty

creation_date
type: AnnotationProperty

has_alternative_id
type: AnnotationProperty

has_broad_synonym
type: AnnotationProperty

database_cross_reference
type: AnnotationProperty

has exact synonym
type: AnnotationProperty
textual definition: A property representing a fully qualified synonym, contains the string, term type, source, and an optional source code if appropriate. Each subfield is deliniated to facilitate interpretation by software.
has exact synonym: FULL_SYN
has exact synonym: Synonym with Source Data
label: has_exact_synonym

has_narrow_synonym
type: AnnotationProperty

has_obo_namespace
type: AnnotationProperty
comment: disease_ontology

has_related_synonym
type: AnnotationProperty

id
type: AnnotationProperty

in subset
type: AnnotationProperty
textual definition: An association that connects the concept defining a particular terminology subset with concepts that belong to this subset.
has exact synonym: Concept_In_Subset
label: in_subset

shorthand
type: AnnotationProperty

label
type: AnnotationProperty
editor preferred label: label

Complication Occurs In
type: ObjectProperty
domain: Complication
range: Physical anatomical entity

Disease Has Associated Anatomic Site
type: ObjectProperty
domain: Disease
range: Anatomical entity
textual definition: A role used to relate a disease to the general site, structure or system where the specific pathological process is located.

Disease Has Primary Anatomic Site
type: ObjectProperty
domain: Disease
range: Anatomical entity
textual definition: A role used to relate a disease to the anatomical site where the originating pathological process is located.

Disease Has Metastatic Anatomic Site
type: ObjectProperty
domain: Disease
range: Anatomical entity
textual definition: A role used to relate a disease to the site of a metastatic lesion associated with the disease.

Disease Has Normal Tissue Origin
type: ObjectProperty
domain: Disease
range: Anatomical entity
textual definition: A role used to relate a disease to the type of normal tissue in which the disease process began.

Disease Has Molecular Abnormality
type: ObjectProperty
domain: Disease
range: Molecular Abnormality
textual definition: A role used to relate a disease to a molecular abnormality that is present in the specified disease state.

Disease Is Grade
type: ObjectProperty
domain: Disease
range: Disease
textual definition: A role used to relate a disease to a grading system which classifies the cancer cells in terms of how abnormal they appear when examined under a microscope.

Disease May Have Associated Disease
type: ObjectProperty
domain: Disease
range: Complication
textual definition: A role used to represent that another disease or disorder will only be observed in some cases of the specified disease.

Disease Has Associated Disease
type: ObjectProperty
domain: Disease
range: Complication
textual definition: A role used to relate a disease to another disease or disorder, but without specification or limitation of the relationship (causality or timing for example).

Procedure Has Target Anatomy
type: ObjectProperty
domain: Surgical Procedure
range: Physical anatomical entity
textual definition: A role used to assert a relationship between a procedure and its target anatomy, specifically that a particular procedure always has an association with the target anatomy. This role should be used when a more specific role cannot be asserted, including procedures targeting blood and other fluids.

Procedure May Have Excised Anatomy
type: ObjectProperty
domain: Surgical Procedure
range: Physical anatomical entity
textual definition: A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure sometimes results in excision of some or all of the specified anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs. It should be used when a more specific role cannot be asserted.

Procedure May Have Partially Excised Anatomy
type: ObjectProperty
domain: Surgical Procedure
range: Physical anatomical entity
textual definition: A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure sometimes results in partial excision of the specified anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs, and where partial excision is explicit or can be inferred

Procedure Has Partially Excised Anatomy
type: ObjectProperty
domain: Surgical Procedure
range: Physical anatomical entity
textual definition: A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure always involves partial excision of the specified anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs, and where partial excision is explicit or can be inferred

Procedure May Have Completely Excised Anatomy
type: ObjectProperty
domain: Surgical Procedure
range: Physical anatomical entity
textual definition: A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure sometimes results in complete excision of the target anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs, and where complete excision is explicit or can be inferred.

Procedure Has Completely Excised Anatomy
type: ObjectProperty
domain: Surgical Procedure
range: Physical anatomical entity
textual definition: A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure always is intended for the complete excision of the target anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs, and where complete excision is explicit or can be inferred.

Procedure Has Target Disease
type: ObjectProperty
domain: Surgical Procedure
range: Disease
textual definition: A role used to assert that a procedure or technical method detects, diagnoses, or treats a specified disease state.

Is Physical Part Of
type: ObjectProperty
domain: Physical anatomical entity
range: Physical anatomical entity
textual definition: A role used to indicate that an anatomic structure has a physical association with a broader system or organ.

Disease Is Stage
type: ObjectProperty
domain: Disease
range: Disease
textual definition: A role used to specify the disease stage of a disease, the extent to which a cancer has spread from the original site to other parts of the body.

Variation Is Biomarker Of
type: ObjectProperty
domain: Molecular Abnormality
range: Disease
textual definition: Gene mutations lead to disease.

Variation Is Biomarker-diagnosis Of
type: ObjectProperty
domain: Molecular Abnormality
range: Disease
textual definition: A gene can be used to diagnose a disease.

Is Target Drug Of Gene Mutation
type: ObjectProperty
domain: Pharmacologic Substance
range: Molecular Abnormality
textual definition: At the cellular and molecular level, drugs can target mutated gene sites.

Disease Has Symptom Of
type: ObjectProperty
domain: Disease
range: Phenotypic abnormality

Disease Treated by Drug
type: ObjectProperty
domain: Disease
range: Pharmacologic Substance
textual definition: Symptoms associated with this disease can be relieved by taking certain drug.

Disease Has Phenotype Of
type: ObjectProperty
domain: Disease
range: Phenotypic abnormality

Pharmacogenomic Effects Disease
type: ObjectProperty
domain: Pharmacologic Substance
range: Disease

Drug Interacts With Associated Drug
type: ObjectProperty
domain: Pharmacologic Substance
range: Pharmacologic Substance
textual definition: The combined effect of two or more drugs in clinic

Drug Synergized By Associated Drug
type: ObjectProperty
domain: Pharmacologic Substance
range: Pharmacologic Substance
textual definition: Two or more drugs will be used together to improve the clinical effects

Drug Antagnized By Associated Drug
type: ObjectProperty
domain: Pharmacologic Substance
range: Pharmacologic Substance
textual definition: When drugs are used together, the effects are weakened or disappeared. In most cases, it is not suitable to use them in pairs.

Abnormality Is Phemotype Of Disease
type: ObjectProperty
domain: Phenotypic abnormality
range: Disease

Abnormality Exits In Excised Anatomy
type: ObjectProperty
domain: Phenotypic abnormality
range: Physical anatomical entity

Genetic Variation Results In Abnormality
type: ObjectProperty
domain: Molecular Abnormality
range: Phenotypic abnormality

Procedure Is Diagnose Of Disease
type: ObjectProperty
domain: Diagnostic Procedure
range: Disease

Disease Has Symptom Of
type: ObjectProperty
domain: Disease
range: Phenotypic abnormality
textual definition: A relation that holds between a disease or an organism and a phenotype

Is Substance That Treats Disease
type: ObjectProperty
domain: Pharmacologic Substance
range: Disease
textual definition: Symptoms associated with this disease can be relieved by taking certain drug.

sensory system disease
type: Class
subclass of: nervous system disease
textual definition: A nervous system disease which is located in a part of the nervous system responsible for processing sensory information that consists of sensory receptors, neural pathways, and parts of the brain involved in sensory perception. Commonly recognized sensory systems are those for vision, hearing, somatic sensation (touch), taste and olfaction (smell).
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0050155
in subset: DO AGR slim
in subset: DO FlyBase slim
in subset: DO GXD slim

organ system cancer
type: Class
subclass of: cancer
textual definition: A cancer that is classified based on the organ it starts in.
imported from: doid.owl
created_by: snadendla
creation_date: 2011-06-13T03:28:33Z
database_cross_reference: MESH:D009371
has_obo_namespace: disease_ontology
id: DOID:0050686

cell type cancer
type: Class
subclass of: cancer
textual definition: A cancer that is classified by the type of cell from which it is derived.
imported from: doid.owl
created_by: snadendla
creation_date: 2011-06-13T03:28:50Z
has_obo_namespace: disease_ontology
id: DOID:0050687
in subset: DO MGI slim

mucosal melanoma
type: Class
subclass of: melanoma
textual definition: A melanoma that has_material_basis_in melanocytes located_in mucosal membranes lining the respiratory, gastrointestinal and urogenital tract.
imported from: doid.owl
created_by: lschriml
creation_date: 2014-10-21T13:51:49Z
has_obo_namespace: disease_ontology
id: DOID:0050929
in subset: DO cancer slim

sensory system cancer
type: Class
subclass of: nervous system cancer
textual definition: A nervous system cancer that is located in the sensory system.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-07-25T01:51:56Z
has_obo_namespace: disease_ontology
id: DOID:0060116

integumentary system cancer
type: Class
subclass of: organ system cancer
subclass of: integumentary system disease
textual definition: An organ system cancer that is located_in the skin, hair and nails.
imported from: doid.owl
created_by: lschriml
creation_date: 2011-07-27T02:31:34Z
has_obo_namespace: disease_ontology
id: DOID:0060122

gallbladder disease
type: Class
subclass of: gastrointestinal system disease
textual definition: A gastrointestinal system disease that is located_in the gallbladder.
imported from: doid.owl
created_by: emitraka
creation_date: 2015-02-02T15:48:08Z
has_alternative_id: DOID:0000000
database_cross_reference: ICD10CM:K82.9
database_cross_reference: ICD9CM:575.9
database_cross_reference: MESH:D005705
database_cross_reference: NCI:C34631
database_cross_reference: OMIM:609918
database_cross_reference: OMIM:609919
database_cross_reference: OMIM:611465
database_cross_reference: SNOMEDCT_US_2019_09_01:39621005
database_cross_reference: UMLS_CUI:C0016977
has_obo_namespace: disease_ontology
id: DOID:0060262
in subset: NCIthesaurus
comment: Xref MGI.

spitzoid melanoma
type: Class
subclass of: skin melanoma
textual definition: A skin melanoma that is characterized by asymmetric shape, diameter greater than 1 cm, a lesion with a deep invasive component, and a high degree of cytologic atypia.
imported from: doid.owl
database_cross_reference: NCI:C136825
has exact synonym: atypical spitz nevus
has_obo_namespace: disease_ontology
id: DOID:0070326
in subset: DO cancer slim
in subset: NCIthesaurus

melanoma in congenital melanocytic nevus
type: Class
subclass of: skin melanoma
textual definition: A skin melanoma that arises from a congenital melanocytic nevus.
imported from: doid.owl
database_cross_reference: GARD:2469
database_cross_reference: ICDO:M8761/3
database_cross_reference: NCI:C48613
database_cross_reference: SNOMEDCT_US_2019_09_01:75931002
has exact synonym: Malignant melanoma in congenital melanocytic nevus
has exact synonym: melanocytic nevi
has_obo_namespace: disease_ontology
id: DOID:0070327
in subset: DO cancer slim
in subset: NCIthesaurus

hepatobiliary system cancer
type: Class
subclass of: gastrointestinal system cancer
textual definition: A gastrointestinal system cancer that is located_in the hepatobiliary system.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0080355

malignant eyelid melanoma
type: Class
subclass of: skin melanoma
imported from: doid.owl
database_cross_reference: NCI:C4358
database_cross_reference: SNOMEDCT_US_2019_09_01:231834005
database_cross_reference: UMLS_CUI:C0339116
has_obo_namespace: disease_ontology
id: DOID:10040
in subset: NCIthesaurus

balloon cell malignant melanoma
type: Class
subclass of: skin melanoma
imported from: doid.owl
database_cross_reference: NCI:C4227
database_cross_reference: SNOMEDCT_US_2019_09_01:403922007
database_cross_reference: UMLS_CUI:C0334426
has_obo_namespace: disease_ontology
id: DOID:10044
in subset: NCIthesaurus

nodular malignant melanoma
type: Class
subclass of: skin melanoma
textual definition: A melanoma that is characterized as highly aggressive and manifests as a uniform blue-black, blue-red, or amelanotic nodule.
imported from: doid.owl
database_cross_reference: GARD:9961
database_cross_reference: NCI:C4225
database_cross_reference: SNOMEDCT_US_2019_09_01:2142002
database_cross_reference: UMLS_CUI:C0334424
has exact synonym: nodular melanoma
has_obo_namespace: disease_ontology
id: DOID:10047
in subset: DO cancer slim
in subset: NCIthesaurus

skin amelanotic melanoma
type: Class
subclass of: skin melanoma
imported from: doid.owl
database_cross_reference: NCI:C4633
database_cross_reference: SNOMEDCT_US_2019_09_01:276751004
database_cross_reference: UMLS_CUI:C0349515
has exact synonym: skin amelanotic malignant melanoma
has_obo_namespace: disease_ontology
id: DOID:10054
in subset: NCIthesaurus

intestinal cancer
type: Class
subclass of: gastrointestinal system cancer
textual definition: A gastrointestinal system cancer that is located_in the intestine.
imported from: doid.owl
database_cross_reference: ICD10CM:C26.0
database_cross_reference: ICD9CM:159.0
database_cross_reference: MESH:D007414
database_cross_reference: NCI:C4572
database_cross_reference: SNOMEDCT_US_2019_09_01:363508008
database_cross_reference: UMLS_CUI:C0346627
has exact synonym: malignant intestinal tumors
has exact synonym: malignant neoplasm of intestine
has_obo_namespace: disease_ontology
id: DOID:10155
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

choroid cancer
type: Class
subclass of: choroid disease
subclass of: uveal cancer
imported from: doid.owl
has_alternative_id: DOID:12760
database_cross_reference: ICD10CM:C69.3
database_cross_reference: ICD9CM:190.6
database_cross_reference: MESH:D002830
database_cross_reference: NCI:C2949
database_cross_reference: NCI:C3566
database_cross_reference: SNOMEDCT_US_2019_09_01:127001008
database_cross_reference: SNOMEDCT_US_2019_09_01:363466008
database_cross_reference: UMLS_CUI:C0008523
database_cross_reference: UMLS_CUI:C0153630
has exact synonym: Choroidal tumor
has exact synonym: choroid neoplasm
has exact synonym: malignant tumor of choroid
has exact synonym: malignant tumor of the Choroid
has exact synonym: neoplasm of choroid
has_obo_namespace: disease_ontology
id: DOID:12759
in subset: NCIthesaurus

rectal disease
type: Class
subclass of: intestinal disease
imported from: doid.owl
database_cross_reference: MESH:D012002
database_cross_reference: SNOMEDCT_US_2019_09_01:5964004
database_cross_reference: UMLS_CUI:C0034882
has_obo_namespace: disease_ontology
id: DOID:1285

scrotum melanoma
type: Class
subclass of: melanoma
subclass of: scrotum neoplasm
imported from: doid.owl
database_cross_reference: NCI:C7361
database_cross_reference: UMLS_CUI:C1331544
has exact synonym: melanoma of scrotum
has_obo_namespace: disease_ontology
id: DOID:13160
in subset: NCIthesaurus

anus cancer
type: Class
subclass of: anus disease
subclass of: large intestine cancer
textual definition: A large intestine cancer that is located_in the anus.
imported from: doid.owl
has_alternative_id: DOID:12240
database_cross_reference: GARD:9300
database_cross_reference: ICD10CM:C21.0
database_cross_reference: ICD10CM:C21.1
database_cross_reference: ICD9CM:154.2
database_cross_reference: ICD9CM:154.3
database_cross_reference: NCI:C7379
database_cross_reference: SNOMEDCT_US_2019_09_01:363352004
database_cross_reference: SNOMEDCT_US_2019_09_01:363490009
database_cross_reference: UMLS_CUI:C0153445
database_cross_reference: UMLS_CUI:C0153446
has exact synonym: anal cancer
has exact synonym: malignant anal tumor
has_obo_namespace: disease_ontology
id: DOID:14110
in subset: NCIthesaurus

malignant anus melanoma
type: Class
subclass of: anus cancer
subclass of: melanoma
imported from: doid.owl
database_cross_reference: NCI:C4639
database_cross_reference: SNOMEDCT_US_2019_09_01:276821000
database_cross_reference: UMLS_CUI:C0349538
has exact synonym: anal melanoma
has exact synonym: malignant melanoma of anus
has_obo_namespace: disease_ontology
id: DOID:14145
in subset: NCIthesaurus

spinal cord melanoma
type: Class
subclass of: melanoma
subclass of: spinal cancer
imported from: doid.owl
database_cross_reference: NCI:C5158
database_cross_reference: UMLS_CUI:C1336045
has exact synonym: melanoma of the Spinal Cord
has_obo_namespace: disease_ontology
id: DOID:14151
in subset: NCIthesaurus

choroid disease
type: Class
subclass of: uveal disease
imported from: doid.owl
database_cross_reference: ICD10CM:H31.9
database_cross_reference: ICD9CM:363.9
database_cross_reference: MESH:D015862
database_cross_reference: NCI:C34468
database_cross_reference: UMLS_CUI:C0008521
has_obo_namespace: disease_ontology
id: DOID:1417
in subset: NCIthesaurus

disease of cellular proliferation
type: Class
subclass of: Disease
textual definition: A disease that is characterized by abnormally rapid cell division.
imported from: doid.owl
IEDB alternative term: neoplasm
has_alternative_id: DOID:0000818
has exact synonym: cell process disease
has exact synonym: neoplasm
has_obo_namespace: disease_ontology
id: DOID:14566
in subset: DO FlyBase slim

reproductive system disease
type: Class
subclass of: disease of anatomical entity
textual definition: A disease of anatomical entity that is located_in reproductive system organs.
imported from: doid.owl
has_alternative_id: DOID:6309
database_cross_reference: NCI:C27613
database_cross_reference: UMLS_CUI:C1335037
has exact synonym: genital system disease
has_obo_namespace: disease_ontology
id: DOID:15
in subset: DO AGR slim
in subset: DO GXD slim
in subset: DO MGI slim
in subset: NCIthesaurus

integumentary system disease
type: Class
subclass of: disease of anatomical entity
textual definition: A disease of anatomical entity that is located_in the integumentary system comprising the skin and its appendages.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:16
in subset: DO AGR slim
in subset: DO GXD slim
in subset: DO MGI slim

cancer
type: Class
subclass of: disease of cellular proliferation
textual definition: A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis.
imported from: doid.owl
database_cross_reference: ICD10CM:C80.1
database_cross_reference: ICD9CM:199
database_cross_reference: ICDO:M8000/3
database_cross_reference: MESH:D009369
database_cross_reference: NCI:C9305
database_cross_reference: SNOMEDCT_US_2019_09_01:363346000
database_cross_reference: UMLS_CUI:C0006826
has exact synonym: malignant neoplasm
has exact synonym: malignant tumor
has exact synonym: primary cancer
has_obo_namespace: disease_ontology
id: DOID:162
in subset: DO AGR slim
in subset: DO FlyBase slim
in subset: DO GXD slim
in subset: NCIthesaurus
comment: Updating out dated UMLS CUI.

melanoma
type: Class
subclass of: cell type cancer
textual definition: A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye.
imported from: doid.owl
database_cross_reference: EFO:0000756
database_cross_reference: KEGG:05218
database_cross_reference: MESH:D008545
database_cross_reference: NCI:C3224
database_cross_reference: SNOMEDCT_US_2019_09_01:2092003
database_cross_reference: UMLS_CUI:C0025202
has exact synonym: Naevocarcinoma
has exact synonym: malignant melanoma
has_obo_namespace: disease_ontology
id: DOID:1909
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

reproductive organ cancer
type: Class
subclass of: organ system cancer
textual definition: An organ system cancer that is manifested in the reproductive organs.
imported from: doid.owl
has_alternative_id: DOID:1900
database_cross_reference: NCI:C3674
database_cross_reference: UMLS_CUI:C0178830
has exact synonym: Reproductive tumor
has exact synonym: malignant reproductive system neoplasm
has_obo_namespace: disease_ontology
has_related_synonym: cancer of reproductive system
id: DOID:193
in subset: NCIthesaurus

rectum malignant melanoma
type: Class
subclass of: melanoma
subclass of: rectum cancer
imported from: doid.owl
database_cross_reference: NCI:C4640
database_cross_reference: SNOMEDCT_US_2019_09_01:276822007
database_cross_reference: UMLS_CUI:C0349539
has exact synonym: malignant melanoma of rectum
has exact synonym: melanoma of rectum
has_obo_namespace: disease_ontology
id: DOID:1992
in subset: NCIthesaurus

rectum cancer
type: Class
subclass of: colorectal cancer
textual definition: A colorectal cancer that is located_in the rectum.
imported from: doid.owl
has_alternative_id: DOID:1989
database_cross_reference: ICD10CM:C20
database_cross_reference: ICD9CM:154.1
database_cross_reference: MESH:D012004
database_cross_reference: NCI:C7418
database_cross_reference: NCI:C9382
database_cross_reference: SNOMEDCT_US_2019_09_01:363351006
database_cross_reference: UMLS_CUI:C0007113
database_cross_reference: UMLS_CUI:C0949022
has exact synonym: carcinoma of rectum
has exact synonym: carcinoma of the rectum
has exact synonym: malignant Rectal tumor
has exact synonym: malignant neoplasm of rectum
has exact synonym: malignant rectum tumor
has exact synonym: malignant tumor of rectum
has exact synonym: rectal cancer
has_obo_namespace: disease_ontology
has_related_synonym: cancer of rectum
id: DOID:1993
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

ocular cancer
type: Class
subclass of: sensory system cancer
subclass of: eye disease
textual definition: A sensory system cancer located_in the eye that is characterized by uncontrolled cellular proliferation in the eye.
imported from: doid.owl
has_alternative_id: DOID:9985
database_cross_reference: ICD9CM:190.8
database_cross_reference: MESH:D005134
database_cross_reference: NCI:C3030
database_cross_reference: SNOMEDCT_US_2019_09_01:371486001
database_cross_reference: UMLS_CUI:C0015414
database_cross_reference: UMLS_CUI:C0153632
has exact synonym: Ocular tumor
has exact synonym: eye neoplasm
has exact synonym: malignant eye neoplasm
has exact synonym: neoplasm of eye
has exact synonym: neoplasm of eye proper
has_obo_namespace: disease_ontology
id: DOID:2174
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

iris disease
type: Class
subclass of: uveal disease
imported from: doid.owl
database_cross_reference: MESH:D007499
database_cross_reference: NCI:C34737
database_cross_reference: SNOMEDCT_US_2019_09_01:85478004
database_cross_reference: UMLS_CUI:C0022078
has_obo_namespace: disease_ontology
id: DOID:240
in subset: NCIthesaurus

nervous system cancer
type: Class
subclass of: organ system cancer
subclass of: nervous system disease
textual definition: An organ system cancer located_in the nervous system that affects the central or peripheral nervous system.
imported from: doid.owl
has_alternative_id: DOID:1193
has_alternative_id: DOID:3195
has_alternative_id: DOID:4695
database_cross_reference: ICD9CM:192.9
database_cross_reference: MESH:D009380
database_cross_reference: NCI:C35562
database_cross_reference: UMLS_CUI:C0027665
database_cross_reference: UMLS_CUI:C0153643
database_cross_reference: UMLS_CUI:C1334956
has exact synonym: malignant neoplasm of nervous system
has exact synonym: neoplasm of nervous system
has exact synonym: nervous system neoplasm
has exact synonym: neural neoplasm
has exact synonym: neural tumor
has exact synonym: tumor of the nervous system
has_obo_namespace: disease_ontology
id: DOID:3093
in subset: NCIthesaurus

gastrointestinal system cancer
type: Class
subclass of: organ system cancer
subclass of: gastrointestinal system disease
textual definition: An organ system cancer located_in gastrointestinal tract that is manifested in organs of the gastrointestinal system.
imported from: doid.owl
has_alternative_id: DOID:4945
has_alternative_id: DOID:8377
database_cross_reference: ICD10CM:C26.9
database_cross_reference: ICD9CM:239.0
database_cross_reference: MESH:D004067
database_cross_reference: MESH:D005770
database_cross_reference: NCI:C3052
database_cross_reference: NCI:C4890
database_cross_reference: SNOMEDCT_US_2019_09_01:126768004
database_cross_reference: SNOMEDCT_US_2019_09_01:128348002
database_cross_reference: SNOMEDCT_US_2019_09_01:428905002
database_cross_reference: UMLS_CUI:C0012243
database_cross_reference: UMLS_CUI:C0017185
database_cross_reference: UMLS_CUI:C0685938
has exact synonym: GI tumor
has exact synonym: digestive system cancer
has exact synonym: gastrointestinal tract cancer
has_obo_namespace: disease_ontology
id: DOID:3119
in subset: DO FlyBase slim
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

gallbladder cancer
type: Class
subclass of: gallbladder disease
subclass of: biliary tract cancer
textual definition: A biliary tract cancer that is located_in the gallbladder.
imported from: doid.owl
has_alternative_id: DOID:8090
has_alternative_id: DOID:8157
database_cross_reference: GARD:9328
database_cross_reference: ICD10CM:C23
database_cross_reference: ICD9CM:156.0
database_cross_reference: MESH:D005706
database_cross_reference: NCI:C3048
database_cross_reference: NCI:C35676
database_cross_reference: NCI:C7481
database_cross_reference: SNOMEDCT_US_2019_09_01:126854002
database_cross_reference: SNOMEDCT_US_2019_09_01:363353009
database_cross_reference: UMLS_CUI:C0016978
database_cross_reference: UMLS_CUI:C0153452
database_cross_reference: UMLS_CUI:C0278806
has exact synonym: gallbladder Ca
has exact synonym: gallbladder neoplasm
has exact synonym: localized malignant gallbladder neoplasm
has exact synonym: malignant neoplasm of gallbladder
has exact synonym: malignant tumor of the gallbladder
has exact synonym: malignant tumour of gallbladder
has exact synonym: tumor of the gallbladder
has_obo_namespace: disease_ontology
id: DOID:3121
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

anus disease
type: Class
subclass of: rectal disease
imported from: doid.owl
has_alternative_id: DOID:11479
has_alternative_id: DOID:11993
database_cross_reference: MESH:D001004
database_cross_reference: NCI:C26695
database_cross_reference: SNOMEDCT_US_2019_09_01:32110003
database_cross_reference: UMLS_CUI:C0003462
has exact synonym: Nontraumatic tear of anus
has exact synonym: Solitary anal ulcer
has exact synonym: Ulcer of anus
has exact synonym: anal disease
has exact synonym: anal fissure
has exact synonym: anal fissure and fistula
has exact synonym: anal ulcer
has exact synonym: fissure in ano
has_obo_namespace: disease_ontology
id: DOID:3128
in subset: NCIthesaurus

malignant spindle cell melanoma
type: Class
subclass of: melanoma
textual definition: A melanoma that is composed of spindled neoplastic cells arranged in sheets and fascicles.
imported from: doid.owl
database_cross_reference: NCI:C4237
database_cross_reference: SNOMEDCT_US_2019_09_01:68827007
database_cross_reference: UMLS_CUI:C0334444
has exact synonym: Spitzoid malignant melanoma
has exact synonym: spindle cell malignant melanoma
has exact synonym: spindle cell melanoma
has_obo_namespace: disease_ontology
has_related_synonym: desmoplastic melanoma
id: DOID:3162
in subset: NCIthesaurus

spinal cord disease
type: Class
subclass of: central nervous system disease
imported from: doid.owl
database_cross_reference: ICD10CM:G95.9
database_cross_reference: ICD9CM:336.9
database_cross_reference: MESH:D013118
database_cross_reference: NCI:C97110
database_cross_reference: SNOMEDCT_US_2019_09_01:48522003
database_cross_reference: UMLS_CUI:C0037928
has_obo_namespace: disease_ontology
has_related_synonym: myelopathy
id: DOID:319
in subset: NCIthesaurus

central nervous system disease
type: Class
subclass of: nervous system disease
textual definition: A nervous system disease that affects either the spinal cord (myelopathy) or brain (encephalopathy) of the central nervous system.
imported from: doid.owl
database_cross_reference: ICD10CM:G96.9
database_cross_reference: MESH:D002493
database_cross_reference: NCI:C2934
database_cross_reference: SNOMEDCT_US_2019_09_01:23853001
database_cross_reference: UMLS_CUI:C0007682
has_obo_namespace: disease_ontology
id: DOID:331
in subset: DO AGR slim
in subset: DO GXD slim
in subset: NCIthesaurus

iris cancer
type: Class
subclass of: iris disease
subclass of: uveal cancer
imported from: doid.owl
has_alternative_id: DOID:6353
database_cross_reference: MESH:D015811
database_cross_reference: NCI:C3142
database_cross_reference: NCI:C4554
database_cross_reference: SNOMEDCT_US_2019_09_01:188264002
database_cross_reference: SNOMEDCT_US_2019_09_01:231964001
database_cross_reference: UMLS_CUI:C0022079
database_cross_reference: UMLS_CUI:C0346372
has exact synonym: malignant neoplasm of the Iris
has exact synonym: malignant tumor of iris
has exact synonym: tumor of the Iris
has_obo_namespace: disease_ontology
id: DOID:3478
in subset: NCIthesaurus

uveal cancer
type: Class
subclass of: ocular cancer
subclass of: uveal disease
textual definition: An ocular cancer that is located_in the uvea, which are the pigmented layers of the eye consisting of the iris, ciliary body, and choroid. The uvea is the most common location of intraocular malignancy in adults and may commonly be caused by a subtype of cancer that arises from melanocytes.
imported from: doid.owl
has_alternative_id: DOID:12754
database_cross_reference: MESH:D014604
database_cross_reference: NCI:C3436
database_cross_reference: NCI:C6105
database_cross_reference: UMLS_CUI:C0042162
database_cross_reference: UMLS_CUI:C1334629
has exact synonym: Uveal tumor
has exact synonym: malignant Uveal tumor
has exact synonym: malignant uvea neoplasm
has_obo_namespace: disease_ontology
id: DOID:3479
in subset: NCIthesaurus

uveal disease
type: Class
subclass of: eye disease
textual definition: An eye disease affecting the uvea, which are the pigmented layers of the eye consisting of the iris, ciliary body, and choroid.
imported from: doid.owl
database_cross_reference: GARD:8192
database_cross_reference: MESH:D014603
database_cross_reference: NCI:C26908
database_cross_reference: SNOMEDCT_US_2019_09_01:95678007
database_cross_reference: UMLS_CUI:C0042161
has_obo_namespace: disease_ontology
id: DOID:3480
in subset: NCIthesaurus

central nervous system cancer
type: Class
subclass of: nervous system cancer
subclass of: central nervous system disease
textual definition: A nervous system cancer that is located_in the central nervous system.
imported from: doid.owl
has_alternative_id: DOID:0060093
has_alternative_id: DOID:1318
database_cross_reference: EFO:0000326
database_cross_reference: ICD10CM:C72.9
database_cross_reference: MESH:D016543
database_cross_reference: NCI:C4627
database_cross_reference: NCI:C9293
database_cross_reference: SNOMEDCT_US_2019_09_01:126951006
database_cross_reference: SNOMEDCT_US_2019_09_01:372062007
database_cross_reference: UMLS_CUI:C0085136
database_cross_reference: UMLS_CUI:C0348374
has exact synonym: CNS neoplasm
has exact synonym: central nervous system tumor
has exact synonym: central nervous system tumors
has exact synonym: malignant neoplasm of central nervous system
has exact synonym: malignant tumor of CNS
has exact synonym: neoplasm of central nervous system
has_obo_namespace: disease_ontology
id: DOID:3620
in subset: NCIthesaurus

skin disease
type: Class
subclass of: integumentary system disease
textual definition: An integumentary system disease that is located_in skin.
imported from: doid.owl
has_alternative_id: DOID:1576
has_alternative_id: DOID:1698
has_alternative_id: DOID:187
has_alternative_id: DOID:6486
has_alternative_id: DOID:8948
database_cross_reference: ICD9CM:702
database_cross_reference: MESH:D012871
database_cross_reference: MESH:D012873
database_cross_reference: NCI:C156032
database_cross_reference: NCI:C27554
database_cross_reference: SNOMEDCT_US_2019_09_01:239001006
database_cross_reference: SNOMEDCT_US_2019_09_01:95320005
database_cross_reference: UMLS_CUI:C0029574
database_cross_reference: UMLS_CUI:C0037274
database_cross_reference: UMLS_CUI:C0037277
has exact synonym: Genodermatosis
has exact synonym: skin and subcutaneous tissue disease
has_obo_namespace: disease_ontology
id: DOID:37
in subset: NCIthesaurus

male reproductive organ cancer
type: Class
subclass of: reproductive organ cancer
subclass of: male reproductive system disease
textual definition: A reproductive organ cancer that is manifested in the male genital system. This includes organs such as the penis and scrotum.
imported from: doid.owl
has_alternative_id: DOID:10284
database_cross_reference: ICD10CM:C63.9
database_cross_reference: ICD9CM:187.9
database_cross_reference: MESH:D005834
database_cross_reference: NCI:C3054
database_cross_reference: NCI:C8561
database_cross_reference: SNOMEDCT_US_2019_09_01:126895004
database_cross_reference: SNOMEDCT_US_2019_09_01:363515000
database_cross_reference: UMLS_CUI:C0017417
database_cross_reference: UMLS_CUI:C0153606
has exact synonym: male genital cancer
has exact synonym: male reproductive system neoplasm
has exact synonym: malignant neoplasm of male genital organ
has exact synonym: malignant neoplasm of male genital organ or tract
has exact synonym: malignant neoplasm of male genital organs
has exact synonym: malignant tumor of male Reproductive system
has exact synonym: malignant tumor of male genital organ
has exact synonym: neoplasm of male genital organ
has exact synonym: tumor of male Reproductive system
has_obo_namespace: disease_ontology
has_related_synonym: male genital neoplasm
id: DOID:3856
in subset: NCIthesaurus

Disease
type: Class
subclass of: melanoma ontology
textual definition: A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism.
imported from: doid.owl
database_cross_reference: MESH:D004194
database_cross_reference: NCI:C2991
database_cross_reference: SNOMEDCT_US_2019_09_01:64572001
database_cross_reference: UMLS_CUI:C0012634
has_obo_namespace: disease_ontology
id: DOID:4
in subset: NCIthesaurus

skin cancer
type: Class
subclass of: integumentary system cancer
subclass of: skin disease
textual definition: An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells.
imported from: doid.owl
database_cross_reference: GARD:10421
database_cross_reference: MESH:D012878
database_cross_reference: NCI:C2920
database_cross_reference: SNOMEDCT_US_2019_09_01:372130007
database_cross_reference: UMLS_CUI:C0007114
has exact synonym: CA - skin cancer
has exact synonym: malignant neoplasm of skin
has exact synonym: melanoma and Non-melanoma skin cancer
has_obo_namespace: disease_ontology
has_related_synonym: cancer of skin
id: DOID:4159
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

ciliary body cancer
type: Class
subclass of: iris cancer
subclass of: ciliary body disease
imported from: doid.owl
has_alternative_id: DOID:6352
database_cross_reference: ICD10CM:C69.4
database_cross_reference: NCI:C4364
database_cross_reference: NCI:C4766
database_cross_reference: SNOMEDCT_US_2019_09_01:126998003
database_cross_reference: SNOMEDCT_US_2019_09_01:188263008
database_cross_reference: UMLS_CUI:C0339349
database_cross_reference: UMLS_CUI:C0496833
has exact synonym: malignant neoplasm of ciliary body
has exact synonym: malignant tumor of ciliary body
has exact synonym: malignant tumor of the Ciliary body
has exact synonym: neoplasm of ciliary body
has exact synonym: tumor of the Ciliary body
has_obo_namespace: disease_ontology
id: DOID:4352
in subset: NCIthesaurus

ciliary body disease
type: Class
subclass of: iris disease
imported from: doid.owl
database_cross_reference: NCI:C35775
database_cross_reference: SNOMEDCT_US_2019_09_01:68575007
database_cross_reference: UMLS_CUI:C0271100
has_obo_namespace: disease_ontology
id: DOID:4353
in subset: NCIthesaurus

amelanotic melanoma
type: Class
subclass of: melanoma
imported from: doid.owl
database_cross_reference: MESH:D018328
database_cross_reference: NCI:C3802
database_cross_reference: SNOMEDCT_US_2019_09_01:70594002
database_cross_reference: UMLS_CUI:C0206735
has exact synonym: Amelanotic melanoma
has_obo_namespace: disease_ontology
id: DOID:4359
in subset: NCIthesaurus

epithelioid cell melanoma
type: Class
subclass of: melanoma
imported from: doid.owl
database_cross_reference: NCI:C4236
database_cross_reference: SNOMEDCT_US_2019_09_01:37138001
database_cross_reference: UMLS_CUI:C0334443
has exact synonym: epithelioid melanoma
has_obo_namespace: disease_ontology
id: DOID:4360
in subset: NCIthesaurus

biliary tract cancer
type: Class
subclass of: hepatobiliary system cancer
textual definition: A hepatobiliary system cancer that results_in malignant growth located_in the gallbladder or located_in the bile duct.
imported from: doid.owl
has_alternative_id: DOID:8092
database_cross_reference: GARD:5924
database_cross_reference: GARD:9304
database_cross_reference: ICD10CM:C24.9
database_cross_reference: ICD9CM:156.9
database_cross_reference: MESH:D001661
database_cross_reference: SNOMEDCT_US_2019_09_01:126853008
database_cross_reference: SNOMEDCT_US_2019_09_01:363415003
database_cross_reference: UMLS_CUI:C0005426
database_cross_reference: UMLS_CUI:C0750952
has exact synonym: malignant tumour of biliary tract
has_obo_namespace: disease_ontology
id: DOID:4607

male reproductive system disease
type: Class
subclass of: reproductive system disease
textual definition: A reproductive system disease that affects male reproductive organs.
imported from: doid.owl
database_cross_reference: ICD10CM:N50.9
database_cross_reference: ICD9CM:608.9
database_cross_reference: MESH:D005832
database_cross_reference: SNOMEDCT_US_2019_09_01:64557000
database_cross_reference: UMLS_CUI:C0017412
has_obo_namespace: disease_ontology
id: DOID:48

scrotum neoplasm
type: Class
subclass of: male reproductive organ cancer
imported from: doid.owl
has_alternative_id: DOID:13158
database_cross_reference: ICD10CM:C63.2
database_cross_reference: ICD9CM:187.7
database_cross_reference: NCI:C3560
database_cross_reference: NCI:C4380
database_cross_reference: SNOMEDCT_US_2019_09_01:126905005
database_cross_reference: SNOMEDCT_US_2019_09_01:363454002
database_cross_reference: UMLS_CUI:C0153604
database_cross_reference: UMLS_CUI:C0341790
has exact synonym: Scrotal Ca
has exact synonym: Scrotal tumor
has exact synonym: malignant Scrotal neoplasm
has exact synonym: malignant tumor of scrotum
has exact synonym: malignant tumour of scrotum
has exact synonym: neoplasm of scrotum
has exact synonym: scrotum cancer
has_obo_namespace: disease_ontology
id: DOID:518
in subset: NCIthesaurus

intestinal disease
type: Class
subclass of: gastrointestinal system disease
textual definition: A gastrointestinal system disease that is located_in the intestine.
imported from: doid.owl
has_alternative_id: DOID:10759
has_alternative_id: DOID:11222
has_alternative_id: DOID:11789
has_alternative_id: DOID:8531
has_alternative_id: DOID:8558
has_alternative_id: DOID:8591
database_cross_reference: ICD10CM:K63.9
database_cross_reference: ICD9CM:569.9
database_cross_reference: MESH:D007410
database_cross_reference: NCI:C26801
database_cross_reference: SNOMEDCT_US_2019_09_01:85919009
database_cross_reference: UMLS_CUI:C0021831
has_obo_namespace: disease_ontology
id: DOID:5295
in subset: NCIthesaurus

spinal cancer
type: Class
subclass of: spinal cord disease
subclass of: central nervous system cancer
textual definition: A central nervous system cancer that is located_in the spinal cord. It is mostly formed from metastases from primary cancers elsewhere (commonly breast, prostate, and lung cancer).
imported from: doid.owl
has_alternative_id: DOID:3638
has_alternative_id: DOID:7225
database_cross_reference: ICD10CM:C72.0
database_cross_reference: ICD9CM:192.2
database_cross_reference: MESH:D013120
database_cross_reference: MESH:D013125
database_cross_reference: NCI:C3381
database_cross_reference: NCI:C3572
database_cross_reference: SNOMEDCT_US_2019_09_01:126962006
database_cross_reference: SNOMEDCT_US_2019_09_01:363475005
database_cross_reference: SNOMEDCT_US_2019_09_01:709289008
database_cross_reference: UMLS_CUI:C0037930
database_cross_reference: UMLS_CUI:C0037939
database_cross_reference: UMLS_CUI:C0153646
has exact synonym: Intraspinal tumor
has exact synonym: malignant tumor of the Spinal Cord
has exact synonym: spinal cord cancer
has exact synonym: spinal cord neoplasm
has exact synonym: tumor of the Spinal Cord
has_obo_namespace: disease_ontology
has_related_synonym: spinal neoplasm
id: DOID:5612
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

eye disease
type: Class
subclass of: sensory system disease
textual definition: An eye and adnexa disease that is located_in the eye.
imported from: doid.owl
has_alternative_id: DOID:2933
database_cross_reference: ICD10CM:H44
database_cross_reference: ICD9CM:379.90
database_cross_reference: MESH:D005128
database_cross_reference: NCI:C26767
database_cross_reference: SNOMEDCT_US_2019_09_01:371405004
database_cross_reference: UMLS_CUI:C0015397
has_obo_namespace: disease_ontology
id: DOID:5614
in subset: DO FlyBase slim
in subset: NCIthesaurus

large intestine cancer
type: Class
subclass of: intestinal cancer
textual definition: An intestinal cancer that effects the long, tube-like organ that is connected to the small intestine at one end and the anus at the other.
imported from: doid.owl
has_alternative_id: DOID:1994
has_alternative_id: DOID:1997
database_cross_reference: ICD10CM:C18.9
database_cross_reference: SNOMEDCT_US_2019_09_01:126837005
database_cross_reference: SNOMEDCT_US_2019_09_01:363510005
database_cross_reference: UMLS_CUI:C0346629
has_obo_namespace: disease_ontology
id: DOID:5672
in subset: NCIthesaurus
in subset: TopNodes DOcancerslim

uveal melanoma
type: Class
subclass of: melanoma
subclass of: uveal cancer
textual definition: A uveal cancer that has_material_basis_in uvea pigment cells.
imported from: doid.owl
database_cross_reference: MESH:C536494
database_cross_reference: NCI:C7712
database_cross_reference: OMIM:155720
database_cross_reference: OMIM:606660
database_cross_reference: OMIM:606661
database_cross_reference: ORDO:39044
database_cross_reference: UMLS_CUI:C0220633
has exact synonym: melanoma of Uvea
has_obo_namespace: disease_ontology
id: DOID:6039
in subset: DO cancer slim
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

choroid spindle cell melanoma
type: Class
subclass of: melanoma
subclass of: malignant choroid melanoma
textual definition: A malignant choroid melanoma that is located_in the choroid.
imported from: doid.owl
database_cross_reference: NCI:C6099
database_cross_reference: UMLS_CUI:C1333027
has exact synonym: spindle cell melanoma of the Choroid
has_obo_namespace: disease_ontology
id: DOID:6041
in subset: NCIthesaurus

ciliary body spindle cell melanoma
type: Class
subclass of: melanoma
subclass of: ciliary body cancer
textual definition: A ciliary body cancer that is located_in the ciliary body and composed of spindled neoplastic cells arranged in sheets and fascicles.
imported from: doid.owl
database_cross_reference: NCI:C6117
database_cross_reference: UMLS_CUI:C1333052
has exact synonym: spindle cell melanoma of the Ciliary body
has_obo_namespace: disease_ontology
id: DOID:6043
in subset: NCIthesaurus

acral lentiginous melanoma
type: Class
subclass of: skin melanoma
textual definition: A skin melanoma that is characterized by slow growth of a small pigmented spot on the skin with a clearly defined edge, surrounded by normal-appearing skin and occurs on occurs on non hair-bairing surfaces including hands and feet, subungual sites, and fingers or toes.
imported from: doid.owl
database_cross_reference: GARD:9570
has exact synonym: acral lentiginous melanoma, malignant
has exact synonym: malignant acral lentiginous melanoma
has_obo_namespace: disease_ontology
id: DOID:6367
in subset: DO cancer slim

malignant choroid melanoma
type: Class
subclass of: choroid cancer
imported from: doid.owl
database_cross_reference: NCI:C4561
database_cross_reference: SNOMEDCT_US_2019_09_01:255021005
database_cross_reference: UMLS_CUI:C0346388
has exact synonym: malignant melanoma of choroid
has exact synonym: melanoma of the Choroid
has_obo_namespace: disease_ontology
id: DOID:6438
in subset: NCIthesaurus

mixed cell uveal melanoma
type: Class
subclass of: uveal melanoma
imported from: doid.owl
database_cross_reference: NCI:C35781
database_cross_reference: UMLS_CUI:C1334782
has_obo_namespace: disease_ontology
id: DOID:6522
in subset: NCIthesaurus

ciliary body mixed cell melanoma
type: Class
subclass of: ciliary body cancer
subclass of: mixed cell uveal melanoma
imported from: doid.owl
database_cross_reference: NCI:C35783
database_cross_reference: UMLS_CUI:C1333051
has_obo_namespace: disease_ontology
id: DOID:6523
in subset: NCIthesaurus

posterior uveal melanoma
type: Class
subclass of: uveal melanoma
imported from: doid.owl
has_alternative_id: DOID:6746
database_cross_reference: NCI:C9089
database_cross_reference: NCI:C9090
database_cross_reference: UMLS_CUI:C0278867
database_cross_reference: UMLS_CUI:C0278868
has exact synonym: medium/large size posterior uveal melanoma
has exact synonym: small size posterior uveal melanoma
has_obo_namespace: disease_ontology
id: DOID:6566
in subset: NCIthesaurus

familial melanoma
type: Class
subclass of: melanoma
imported from: doid.owl
database_cross_reference: NCI:C8498
database_cross_reference: UMLS_CUI:C1512419
has_obo_namespace: disease_ontology
id: DOID:6846
in subset: NCIthesaurus

malignant iris melanoma
type: Class
subclass of: iris cancer
imported from: doid.owl
database_cross_reference: NCI:C9088
database_cross_reference: SNOMEDCT_US_2019_09_01:255012009
database_cross_reference: UMLS_CUI:C0346373
has exact synonym: malignant melanoma of iris
has exact synonym: melanoma of the Iris
has_obo_namespace: disease_ontology
id: DOID:6994
in subset: NCIthesaurus

disease of anatomical entity
type: Class
subclass of: Disease
textual definition: A disease that manifests in a defined anatomical structure.
imported from: doid.owl
has_alternative_id: DOID:1
has_alternative_id: DOID:2
has_alternative_id: DOID:5
has_alternative_id: DOID:71
has_alternative_id: DOID:72
has_alternative_id: DOID:8
has_obo_namespace: disease_ontology
id: DOID:7

uveal epithelioid cell melanoma
type: Class
subclass of: epithelioid cell melanoma
subclass of: uveal melanoma
imported from: doid.owl
database_cross_reference: NCI:C35780
database_cross_reference: UMLS_CUI:C1333422
has_obo_namespace: disease_ontology
id: DOID:7040
in subset: NCIthesaurus

choroid epithelioid cell melanoma
type: Class
subclass of: epithelioid cell melanoma
subclass of: malignant choroid melanoma
imported from: doid.owl
database_cross_reference: NCI:C6102
database_cross_reference: UMLS_CUI:C1333024
has exact synonym: Choroidal epithelioid cell melanoma
has_obo_namespace: disease_ontology
id: DOID:7041
in subset: NCIthesaurus

ciliary body epithelioid cell melanoma
type: Class
subclass of: ciliary body cancer
subclass of: uveal epithelioid cell melanoma
imported from: doid.owl
database_cross_reference: NCI:C6119
database_cross_reference: UMLS_CUI:C1333050
has_obo_namespace: disease_ontology
id: DOID:7042
in subset: NCIthesaurus

melanomatosis
type: Class
subclass of: melanoma
imported from: doid.owl
database_cross_reference: NCI:C9499
database_cross_reference: UMLS_CUI:C1334691
has_obo_namespace: disease_ontology
id: DOID:7206
in subset: NCIthesaurus

iris spindle cell melanoma
type: Class
subclass of: melanoma
subclass of: malignant iris melanoma
textual definition: A malignant melanoma of iris and spindle cell intraocular melanoma that is located_in the iris.
imported from: doid.owl
database_cross_reference: NCI:C6098
database_cross_reference: UMLS_CUI:C1334287
has_obo_namespace: disease_ontology
id: DOID:7328
in subset: NCIthesaurus

gastrointestinal system disease
type: Class
subclass of: disease of anatomical entity
textual definition: A disease of anatomical entity that is located_in the gastrointestinal tract.
imported from: doid.owl
has_alternative_id: DOID:27
has_alternative_id: DOID:944
database_cross_reference: ICD10CM:K92.9
database_cross_reference: ICD9CM:520-579.99
database_cross_reference: MESH:D004066
database_cross_reference: SNOMEDCT_US_2019_09_01:53619000
database_cross_reference: UMLS_CUI:C0012242
has exact synonym: GIT disease
has exact synonym: Gastroenteropathy
has exact synonym: alimentary system disease
has exact synonym: digestive system disorder
has exact synonym: gastrointestinal disease
has exact synonym: gastrointestinal disorder
has_obo_namespace: disease_ontology
id: DOID:77
in subset: DO AGR slim
in subset: DO GXD slim
in subset: DO MGI slim

choroid necrotic melanoma
type: Class
subclass of: choroid cancer
subclass of: necrotic uveal melanoma
imported from: doid.owl
database_cross_reference: NCI:C6865
database_cross_reference: UMLS_CUI:C1333026
has exact synonym: necrotic Choroid melanoma
has_obo_namespace: disease_ontology
id: DOID:7807
in subset: NCIthesaurus

necrotic uveal melanoma
type: Class
subclass of: uveal melanoma
textual definition: An uveal melanoma characterized by the presence of tumor cell necrosis.
imported from: doid.owl
database_cross_reference: NCI:C7990
database_cross_reference: UMLS_CUI:C0279695
has_obo_namespace: disease_ontology
id: DOID:7808
in subset: NCIthesaurus

gallbladder melanoma
type: Class
subclass of: melanoma
subclass of: gallbladder cancer
imported from: doid.owl
database_cross_reference: NCI:C5735
database_cross_reference: UMLS_CUI:C1333749
has exact synonym: malignant melanoma of gallbladder
has_obo_namespace: disease_ontology
id: DOID:8167
in subset: NCIthesaurus

nervous system disease
type: Class
subclass of: disease of anatomical entity
textual definition: A disease of anatomical entity that is located_in the central nervous system or located_in the peripheral nervous system.
imported from: doid.owl
database_cross_reference: ICD10CM:G98
database_cross_reference: ICD9CM:349.9
database_cross_reference: MESH:D009422
database_cross_reference: NCI:C26835
database_cross_reference: SNOMEDCT_US_2019_09_01:118940003
database_cross_reference: UMLS_CUI:C0027765
has_obo_namespace: disease_ontology
id: DOID:863
in subset: DO GXD slim
in subset: DO MGI slim
in subset: NCIthesaurus

skin melanoma
type: Class
subclass of: melanoma
subclass of: skin cancer
textual definition: A skin cancer that has_material_basis_in melanocytes.
imported from: doid.owl
has_alternative_id: DOID:0050609
has_alternative_id: DOID:10043
has_alternative_id: DOID:10046
has_alternative_id: DOID:10051
has_alternative_id: DOID:10052
has_alternative_id: DOID:10055
has_alternative_id: DOID:8922
database_cross_reference: ICD10CM:C43.9
database_cross_reference: ICD9CM:172.9
database_cross_reference: MESH:C562393
database_cross_reference: NCI:C3510
database_cross_reference: OMIM:608035
database_cross_reference: OMIM:612263
database_cross_reference: SNOMEDCT_US_2019_09_01:93655004
database_cross_reference: UMLS_CUI:C0151779
has exact synonym: cutaneous melanoma
has exact synonym: malignant ear melanoma
has exact synonym: malignant lip melanoma
has exact synonym: malignant lower limb melanoma
has exact synonym: malignant melanoma of ear and/or external auricular canal
has exact synonym: malignant melanoma of skin of lower limb
has exact synonym: malignant melanoma of skin of trunk except scrotum
has exact synonym: malignant melanoma of skin of upper limb
has exact synonym: malignant neck melanoma
has exact synonym: malignant scalp melanoma
has exact synonym: malignant trunk melanoma
has exact synonym: malignant upper limb melanoma
has_obo_namespace: disease_ontology
id: DOID:8923
in subset: DO cancer slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [LS].

colorectal cancer
type: Class
subclass of: large intestine cancer
textual definition: A large intestine cancer that is located_in the colon and/or located_in the rectum.
imported from: doid.owl
database_cross_reference: KEGG:05210
database_cross_reference: MESH:D015179
database_cross_reference: NCI:C2956
database_cross_reference: NCI:C4978
database_cross_reference: OMIM:114500
database_cross_reference: UMLS_CUI:C0009404
database_cross_reference: UMLS_CUI:C0346629
has_obo_namespace: disease_ontology
id: DOID:9256
in subset: DO FlyBase slim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

Eyeball
type: Class
subclass of: Organ with organ cavity
textual definition: Organ with organ cavity which is connected to the optic nerve. Examples: There are only two eyeballs, the right and the left eyeballs..
imported from: fma.owl
has_obo_namespace: fma
id: FMA:12513

Right eyeball
type: Class
subclass of: Eyeball
imported from: fma.owl
has_obo_namespace: fma
id: FMA:12514

Left eyeball
type: Class
subclass of: Eyeball
imported from: fma.owl
has_obo_namespace: fma
id: FMA:12515

Organ component
type: Class
subclass of: Cardinal organ part
textual definition: Cardinal organ part which is bounded predominantly by bonafide boundaries. Examples: lobe of lung, osteon, acinus, submucosa, anterior leaflet of mitral valve, capsule of kidney, cortical bone, muscle fasciculus.
imported from: fma.owl
has_obo_namespace: fma
id: FMA:14065

Back
type: Class
subclass of: Subdivision of body proper
imported from: fma.owl
has exact synonym: Back of body proper
has_obo_namespace: fma
id: FMA:14181

Rectum
type: Class
subclass of: Cardinal organ part
imported from: fma.owl
has_obo_namespace: fma
id: FMA:14544

Mucosa of stomach
type: Class
subclass of: Mucosa
imported from: fma.owl
has exact synonym: Gastric mucosa
has exact synonym: Gastric mucous membrane
has exact synonym: Mucous membrane of stomach
has exact synonym: Tunica mucosa (Gaster)
has_obo_namespace: fma
id: FMA:14907

Mucosa of small intestine
type: Class
subclass of: Mucosa
imported from: fma.owl
has exact synonym: Mucous membrane of small intestine
has exact synonym: Small intestinal mucosa
has exact synonym: Small intestine mucous membrane
has exact synonym: Tunica mucosa (Intestinum tenue)
has_obo_namespace: fma
id: FMA:14933

Mucosa of large intestine
type: Class
subclass of: Mucosa
imported from: fma.owl
has exact synonym: Large intestinal mucosa
has exact synonym: Mucous membrane of large intestine
has_obo_namespace: fma
id: FMA:14969

Mucosa of appendix
type: Class
subclass of: Mucosa
imported from: fma.owl
has exact synonym: Appendiceal mucous membrane
has exact synonym: Appendix mucosa
has exact synonym: Mucosa of vermiform appendix
has_obo_namespace: fma
id: FMA:14991

Anal canal
type: Class
subclass of: Organ with organ cavity
textual definition: Organ with organ cavity which is continuous proximally with the rectum and distally terminates with the anus. Examples: There is only one anal canal.
imported from: fma.owl
has exact synonym: Anal canal viewed anatomically
has exact synonym: Anatomical anal canal
has_obo_namespace: fma
id: FMA:15703

Anus
type: Class
subclass of: Anatomical space
imported from: fma.owl
has exact synonym: Anal orifice
has_obo_namespace: fma
id: FMA:15711

Organ system cavity
type: Class
subclass of: Anatomical cavity
imported from: fma.owl
has_obo_namespace: fma
id: FMA:17445

Lumen of female genital system
type: Class
subclass of: Organ system cavity
imported from: fma.owl
has exact synonym: Female genital tract lumen
has exact synonym: Lumen of female genital tract
has_obo_namespace: fma
id: FMA:17447

Lumen of male genital tract
type: Class
subclass of: Organ system cavity
imported from: fma.owl
has exact synonym: Lumen of male genital system
has exact synonym: Male genital tract lumen
has_obo_namespace: fma
id: FMA:17450

Vulva
type: Class
subclass of: Anatomical cluster
imported from: fma.owl
has exact synonym: Female pudendum
has exact synonym: Puboperineal region
has_obo_namespace: fma
id: FMA:20462

Male thorax
type: Class
subclass of: Thorax
imported from: fma.owl
has exact synonym: Male chest
has_obo_namespace: fma
id: FMA:223653

Female thorax
type: Class
subclass of: Thorax
imported from: fma.owl
has exact synonym: Female chest
has_obo_namespace: fma
id: FMA:223655

Throat
type: Class
subclass of: Subdivision of body proper
imported from: fma.owl
has_obo_namespace: fma
id: FMA:228738

Subdivision of body proper
type: Class
subclass of: Subdivision of cardinal body part
imported from: fma.owl
has_obo_namespace: fma
id: FMA:231430

Free limb segment
type: Class
subclass of: Subdivision of cardinal body part
imported from: fma.owl
has_obo_namespace: fma
id: FMA:241863

Thumb
type: Class
subclass of: Finger
imported from: fma.owl
has exact synonym: First digit of hand
has_obo_namespace: fma
id: FMA:24938

Index finger
type: Class
subclass of: Finger
imported from: fma.owl
has exact synonym: Second digit of hand
has exact synonym: Second finger
has_obo_namespace: fma
id: FMA:24946

Middle finger
type: Class
subclass of: Finger
imported from: fma.owl
has exact synonym: Third digit of hand
has exact synonym: Third finger
has_obo_namespace: fma
id: FMA:24947

Ring finger
type: Class
subclass of: Finger
imported from: fma.owl
has exact synonym: Fourth digit of hand
has exact synonym: Fourth finger
has_obo_namespace: fma
id: FMA:24948

Little finger
type: Class
subclass of: Finger
imported from: fma.owl
has exact synonym: Fifth digit of hand
has exact synonym: Fifth finger
has_obo_namespace: fma
id: FMA:24949

Leg
type: Class
subclass of: Free limb segment
imported from: fma.owl
has exact synonym: Intermediate segment of free lower limb
has_obo_namespace: fma
id: FMA:24979

Right leg
type: Class
subclass of: Leg
imported from: fma.owl
has_obo_namespace: fma
id: FMA:24980

Left leg
type: Class
subclass of: Leg
imported from: fma.owl
has_obo_namespace: fma
id: FMA:24981

Segment of foot
type: Class
subclass of: Free limb segment
imported from: fma.owl
has exact synonym: Foot region
has exact synonym: Foot subdivision
has exact synonym: Subdivision of foot
has_obo_namespace: fma
id: FMA:24993

Heel
type: Class
subclass of: Segment of foot
imported from: fma.owl
has exact synonym: Calcaneal region
has exact synonym: Heel region
has_obo_namespace: fma
id: FMA:24994

Right heel
type: Class
subclass of: Heel
imported from: fma.owl
has_obo_namespace: fma
id: FMA:24995

Left heel
type: Class
subclass of: Heel
imported from: fma.owl
has_obo_namespace: fma
id: FMA:24996

Toe
type: Class
subclass of: Segment of foot
imported from: fma.owl
has exact synonym: Digit of foot
has_obo_namespace: fma
id: FMA:25046

Big toe
type: Class
subclass of: Toe
imported from: fma.owl
has exact synonym: Great toe
has exact synonym: Hallux; Digitus primus [I]
has_obo_namespace: fma
id: FMA:25047

Second toe
type: Class
subclass of: Toe
imported from: fma.owl
has exact synonym: Digitus secundus [II]
has exact synonym: Second digit of foot
has_obo_namespace: fma
id: FMA:25048

Third toe
type: Class
subclass of: Toe
imported from: fma.owl
has exact synonym: Digitus tertius [III]
has exact synonym: Third digit of foot
has_obo_namespace: fma
id: FMA:25051

Fourth toe
type: Class
subclass of: Toe
imported from: fma.owl
has exact synonym: Digitus quartus [IV]
has exact synonym: Fourth digit of foot
has_obo_namespace: fma
id: FMA:25052

Little toe
type: Class
subclass of: Toe
imported from: fma.owl
has exact synonym: Digitus minimus; Digitus quintus [V]
has exact synonym: Fifth digit of foot
has exact synonym: Fifth toe
has_obo_namespace: fma
id: FMA:25053

Male abdomen
type: Class
subclass of: Abdomen
imported from: fma.owl
has_obo_namespace: fma
id: FMA:259092

Female abdomen
type: Class
subclass of: Abdomen
imported from: fma.owl
has_obo_namespace: fma
id: FMA:259094

Subdivision of trunk proper
type: Class
subclass of: Subdivision of body proper
imported from: fma.owl
has_obo_namespace: fma
id: FMA:259102

Upper respiratory tract
type: Class
subclass of: Anatomical structure
textual definition: Subdivision of respiratory system which consists of the nose, nasopharynx, oropharynx and larynx
imported from: fma.owl
has_obo_namespace: fma
id: FMA:45661

Pharynx
type: Class
subclass of: Anatomical cluster
imported from: fma.owl
has_obo_namespace: fma
id: FMA:46688

Anatomical cluster
type: Class
subclass of: Anatomical structure
textual definition: Anatomical structure, which has as its parts a heterogeneous collection of organs, organ parts, cells, cell parts or body part subdivisions that are adjacent to, or continuous with one another; does not constitute a cell part, cell, tissue, organ, organ system or organ system subdivision, cardinal body part, body part subdivision or anatomical junction. Examples: joint, adnexa of uterus, root of lung, renal pedicle, back.
imported from: fma.owl
has_obo_namespace: fma
id: FMA:49443

Nail
type: Class
subclass of: Anatomical structure
imported from: fma.owl
has exact synonym: Nail plate
has_obo_namespace: fma
id: FMA:54326

Nail of finger
type: Class
subclass of: Nail
imported from: fma.owl
has exact synonym: Finger nail
has exact synonym: Fingernail
has exact synonym: Nail plate of finger
has_obo_namespace: fma
id: FMA:54327

Nail of toe
type: Class
subclass of: Nail
imported from: fma.owl
has exact synonym: Nail plate of toe
has exact synonym: Toe nail
has exact synonym: Toenail
has_obo_namespace: fma
id: FMA:54328

Nail of thumb
type: Class
subclass of: Nail of finger
imported from: fma.owl
has exact synonym: Nail plate of thumb
has exact synonym: Thumb nail
has_obo_namespace: fma
id: FMA:54329

Nail of right thumb
type: Class
subclass of: Nail of thumb
imported from: fma.owl
has exact synonym: Nail plate of right thumb
has exact synonym: Right thumb nail
has_obo_namespace: fma
id: FMA:54330

Nail of left thumb
type: Class
subclass of: Nail of thumb
imported from: fma.owl
has exact synonym: Left thumb nail
has exact synonym: Nail plate of left thumb
has_obo_namespace: fma
id: FMA:54331

Nail of index finger
type: Class
subclass of: Nail of finger
imported from: fma.owl
has exact synonym: Index finger nail
has exact synonym: Nail of second finger
has exact synonym: Nail plate of index finger
has_obo_namespace: fma
id: FMA:54332

Nail of right index finger
type: Class
subclass of: Nail of index finger
imported from: fma.owl
has exact synonym: Nail plate of right index finger
has exact synonym: Right index finger nail
has_obo_namespace: fma
id: FMA:54333

Nail of left index finger
type: Class
subclass of: Nail of index finger
imported from: fma.owl
has exact synonym: Left index finger nail
has exact synonym: Nail plate of left index finger
has_obo_namespace: fma
id: FMA:54334

Nail of middle finger
type: Class
subclass of: Nail of finger
imported from: fma.owl
has exact synonym: Middle finger nail
has exact synonym: Nail of third finger
has exact synonym: Nail plate of middle finger
has_obo_namespace: fma
id: FMA:54335

Nail of right middle finger
type: Class
subclass of: Nail of middle finger
imported from: fma.owl
has exact synonym: Nail plate of right middle finger
has exact synonym: Right middle finger nail
has_obo_namespace: fma
id: FMA:54336

Nail of left middle finger
type: Class
subclass of: Nail of middle finger
imported from: fma.owl
has exact synonym: Left middle finger nail
has exact synonym: Nail plate of left middle finger
has_obo_namespace: fma
id: FMA:54337

Nail of ring finger
type: Class
subclass of: Nail of finger
imported from: fma.owl
has exact synonym: Nail of fourth finger
has exact synonym: Nail plate of ring finger
has exact synonym: Ring finger nail
has_obo_namespace: fma
id: FMA:54338

Nail of right ring finger
type: Class
subclass of: Nail of ring finger
imported from: fma.owl
has exact synonym: Nail plate of right ring finger
has exact synonym: Right ring finger nail
has_obo_namespace: fma
id: FMA:54339

Nail of left ring finger
type: Class
subclass of: Nail of ring finger
imported from: fma.owl
has exact synonym: Left ring finger nail
has exact synonym: Nail plate of left ring finger
has_obo_namespace: fma
id: FMA:54340

Nail of little finger
type: Class
subclass of: Nail of finger
imported from: fma.owl
has exact synonym: Little finger nail
has exact synonym: Nail of fifth finger
has exact synonym: Nail plate of little finger
has_obo_namespace: fma
id: FMA:54341

Nail of right little finger
type: Class
subclass of: Nail of little finger
imported from: fma.owl
has exact synonym: Nail plate of right little finger
has exact synonym: Right little finger nail
has_obo_namespace: fma
id: FMA:54342

Nail of left little finger
type: Class
subclass of: Nail of little finger
imported from: fma.owl
has exact synonym: Left little finger nail
has exact synonym: Nail plate of left little finger
has_obo_namespace: fma
id: FMA:54343

Nail of big toe
type: Class
subclass of: Nail of toe
imported from: fma.owl
has exact synonym: Big toe nail
has exact synonym: Nail of great toe
has exact synonym: Nail plate of big toe
has_obo_namespace: fma
id: FMA:54344

Nail of right big toe
type: Class
subclass of: Nail of big toe
imported from: fma.owl
has exact synonym: Nail of right great toe
has exact synonym: Nail plate of right big toe
has exact synonym: Right big toe nail
has_obo_namespace: fma
id: FMA:54345

Nail of left big toe
type: Class
subclass of: Nail of big toe
imported from: fma.owl
has exact synonym: Left big toe nail
has exact synonym: Nail of left great toe
has exact synonym: Nail plate of left big toe
has_obo_namespace: fma
id: FMA:54346

Nail of second toe
type: Class
subclass of: Nail of toe
imported from: fma.owl
has exact synonym: Nail plate of second toe
has exact synonym: Second toe nail
has_obo_namespace: fma
id: FMA:54347

Nail of right second toe
type: Class
subclass of: Nail of second toe
imported from: fma.owl
has exact synonym: Nail plate of right second toe
has exact synonym: Right second toe nail
has_obo_namespace: fma
id: FMA:54348

Nail of left second toe
type: Class
subclass of: Nail of second toe
imported from: fma.owl
has exact synonym: Left second toe nail
has exact synonym: Nail plate of left second toe
has_obo_namespace: fma
id: FMA:54349

Nail of third toe
type: Class
subclass of: Nail of toe
imported from: fma.owl
has exact synonym: Nail plate of third toe
has exact synonym: Third toe nail
has_obo_namespace: fma
id: FMA:54350

Nail of right third toe
type: Class
subclass of: Nail of third toe
imported from: fma.owl
has exact synonym: Nail plate of right third toe
has exact synonym: Right third toe nail
has_obo_namespace: fma
id: FMA:54351

Nail of left third toe
type: Class
subclass of: Nail of third toe
imported from: fma.owl
has exact synonym: Left third toe nail
has exact synonym: Nail plate of left third toe
has_obo_namespace: fma
id: FMA:54352

Nail of fourth toe
type: Class
subclass of: Nail of toe
imported from: fma.owl
has exact synonym: Fourth toe nail
has exact synonym: Nail plate of fourth toe
has_obo_namespace: fma
id: FMA:54353

Nail of right fourth toe
type: Class
subclass of: Nail of fourth toe
imported from: fma.owl
has exact synonym: Nail plate of right fourth toe
has exact synonym: Right fourth toe nail
has_obo_namespace: fma
id: FMA:54354

Nail of left fourth toe
type: Class
subclass of: Nail of fourth toe
imported from: fma.owl
has exact synonym: Left fourth toe nail
has exact synonym: Nail plate of left fourth toe
has_obo_namespace: fma
id: FMA:54355

Nail of little toe
type: Class
subclass of: Nail of toe
imported from: fma.owl
has exact synonym: Little toe nail
has exact synonym: Nail of fifth toe
has exact synonym: Nail plate of little toe
has_obo_namespace: fma
id: FMA:54356

Nail of right little toe
type: Class
subclass of: Nail of little toe
imported from: fma.owl
has exact synonym: Nail of right fifth toe
has exact synonym: Nail plate of right little toe
has exact synonym: Right little toe nail
has_obo_namespace: fma
id: FMA:54357

Nail of left little toe
type: Class
subclass of: Nail of little toe
imported from: fma.owl
has exact synonym: Left little toe nail
has exact synonym: Nail of left fifth toe
has exact synonym: Nail plate of left little toe
has_obo_namespace: fma
id: FMA:54358

Subdivision of face
type: Class
subclass of: Subdivision of cardinal body part
imported from: fma.owl
has exact synonym: Face subdivision
has exact synonym: Facial region
has exact synonym: Region of face
has_obo_namespace: fma
id: FMA:54393

Eyelid
type: Class
subclass of: Subdivision of face
imported from: fma.owl
has exact synonym: Blepharon
has exact synonym: Palpebra
has_obo_namespace: fma
id: FMA:54437

Upper eyelid
type: Class
subclass of: Eyelid
imported from: fma.owl
has exact synonym: Superior eyelid
has_obo_namespace: fma
id: FMA:54439

Right upper eyelid
type: Class
subclass of: Upper eyelid
imported from: fma.owl
has exact synonym: Right superior eyelid
has_obo_namespace: fma
id: FMA:54440

Left upper eyelid
type: Class
subclass of: Upper eyelid
imported from: fma.owl
has exact synonym: Left superior eyelid
has_obo_namespace: fma
id: FMA:54441

Lower eyelid
type: Class
subclass of: Eyelid
imported from: fma.owl
has exact synonym: Inferior eyelid
has_obo_namespace: fma
id: FMA:54442

Right lower eyelid
type: Class
subclass of: Lower eyelid
imported from: fma.owl
has exact synonym: Right inferior eyelid
has_obo_namespace: fma
id: FMA:54443

Left lower eyelid
type: Class
subclass of: Lower eyelid
imported from: fma.owl
has exact synonym: Left inferior eyelid
has_obo_namespace: fma
id: FMA:54444

Eye
type: Class
subclass of: Subdivision of face
imported from: fma.owl
has exact synonym: Orbital part of face
has exact synonym: Orbital region
has_obo_namespace: fma
id: FMA:54448

Right eye
type: Class
subclass of: Eye
imported from: fma.owl
has exact synonym: Right orbital part of face
has exact synonym: Right orbital region
has_obo_namespace: fma
id: FMA:54449

Left eye
type: Class
subclass of: Eye
imported from: fma.owl
has exact synonym: Left orbital part of face
has exact synonym: Left orbital region
has_obo_namespace: fma
id: FMA:54450

Nonparenchymatous organ
type: Class
subclass of: Organ
textual definition: Solid organ which consists of organ parts that are arranged as fascicles or sheets. Examples: muscle (organ), ligament (organ), membrane (organ), skin, viscerocranial mucosa.
imported from: fma.owl
has_obo_namespace: fma
id: FMA:55665

Organ with organ cavity
type: Class
subclass of: Organ
textual definition: Cavitated organ in which its unshared parts surround one continuous anatomical space. Examples: stomach, urinary bladder, esophagus, uterine tube.
imported from: fma.owl
has_obo_namespace: fma
id: FMA:55672

Vascular layer of eyeball
type: Class
subclass of: Organ component layer
imported from: fma.owl
has exact synonym: Tunica vasculosa of eyeball
has exact synonym: Uvea
has exact synonym: Uveal tract
has_obo_namespace: fma
id: FMA:58103

Iris
type: Class
subclass of: Vascular layer of eyeball
imported from: fma.owl
has_obo_namespace: fma
id: FMA:58235

Ciliary body
type: Class
subclass of: Vascular layer of eyeball
imported from: fma.owl
has_obo_namespace: fma
id: FMA:58295

Choroid
type: Class
subclass of: Vascular layer of eyeball
imported from: fma.owl
has_obo_namespace: fma
id: FMA:58298

Anatomical space
type: Class
subclass of: Physical anatomical entity
textual definition: Immaterial anatomical entity which has three spatial dimensions. Examples: celom, thoracic cavity, lesser sac of peritoneum, cavity of right atrium, lumen of aorta, mediastinal space, space of anterior compartment of forearm, intervertebral foramen space.
imported from: fma.owl
has_obo_namespace: fma
id: FMA:5897

Conjunctiva
type: Class
subclass of: Organ component
imported from: fma.owl
has exact synonym: Wall of conjunctival sac
has_obo_namespace: fma
id: FMA:59011

Right conjunctiva
type: Class
subclass of: Conjunctiva
imported from: fma.owl
has exact synonym: Conjunctiva of right eye
has exact synonym: Wall of right conjunctival sac
has_obo_namespace: fma
id: FMA:59012

Left conjunctiva
type: Class
subclass of: Conjunctiva
imported from: fma.owl
has exact synonym: Conjunctiva of left eye
has exact synonym: Wall of left conjunctival sac
has_obo_namespace: fma
id: FMA:59013

Mucosa of mouth
type: Class
subclass of: Viscerocranial mucosa organ part
imported from: fma.owl
has exact synonym: Mouth mucosa
has exact synonym: Mucous membrane of mouth
has exact synonym: Oral part of viscerocranial mucosa
has_obo_namespace: fma
id: FMA:59660

Paranasal sinus
type: Class
subclass of: Anatomical cavity
imported from: fma.owl
has_obo_namespace: fma
id: FMA:59679

Mucosa of nose
type: Class
subclass of: Viscerocranial mucosa organ part
imported from: fma.owl
has exact synonym: Mucous membrane of nose
has exact synonym: Nasal mucosa
has_obo_namespace: fma
id: FMA:59684

Mucosa of pharyngotympanic tube
type: Class
subclass of: Mucosa
imported from: fma.owl
has exact synonym: Mucous membrane of auditory tube
has exact synonym: Mucous membrane of pharyngotympanic tube
has exact synonym: Mucuous membrane of Eustachian tube
has exact synonym: Mucuous membrane of pharyngotympanic tube
has exact synonym: Pharyngotympanic tube mucosa
has exact synonym: Tunica mucosa (Tuba auditiva)
has exact synonym: Tunica mucosa (Tuba auditoria)
has_obo_namespace: fma
id: FMA:60109

Right thumb
type: Class
subclass of: Thumb
imported from: fma.owl
has_obo_namespace: fma
id: FMA:60325

Left thumb
type: Class
subclass of: Thumb
imported from: fma.owl
has_obo_namespace: fma
id: FMA:60326

Right little finger
type: Class
subclass of: Little finger
imported from: fma.owl
has_obo_namespace: fma
id: FMA:60327

Left little finger
type: Class
subclass of: Little finger
imported from: fma.owl
has_obo_namespace: fma
id: FMA:60328

Right ring finger
type: Class
subclass of: Ring finger
imported from: fma.owl
has_obo_namespace: fma
id: FMA:60329

Left ring finger
type: Class
subclass of: Ring finger
imported from: fma.owl
has_obo_namespace: fma
id: FMA:60330

Right middle finger
type: Class
subclass of: Middle finger
imported from: fma.owl
has_obo_namespace: fma
id: FMA:60331

Left middle finger
type: Class
subclass of: Middle finger
imported from: fma.owl
has_obo_namespace: fma
id: FMA:60332

Right index finger
type: Class
subclass of: Index finger
imported from: fma.owl
has_obo_namespace: fma
id: FMA:60333

Left index finger
type: Class
subclass of: Index finger
imported from: fma.owl
has_obo_namespace: fma
id: FMA:60334

Right big toe
type: Class
subclass of: Big toe
imported from: fma.owl
has_obo_namespace: fma
id: FMA:60335

Left big toe
type: Class
subclass of: Big toe
imported from: fma.owl
has_obo_namespace: fma
id: FMA:60336

Right second toe
type: Class
subclass of: Second toe
imported from: fma.owl
has_obo_namespace: fma
id: FMA:60337

Left second toe
type: Class
subclass of: Second toe
imported from: fma.owl
has_obo_namespace: fma
id: FMA:60338

Right third toe
type: Class
subclass of: Third toe
imported from: fma.owl
has_obo_namespace: fma
id: FMA:60339

Left third toe
type: Class
subclass of: Third toe
imported from: fma.owl
has_obo_namespace: fma
id: FMA:60340

Right fourth toe
type: Class
subclass of: Fourth toe
imported from: fma.owl
has_obo_namespace: fma
id: FMA:60341

Left fourth toe
type: Class
subclass of: Fourth toe
imported from: fma.owl
has_obo_namespace: fma
id: FMA:60342

Right little toe
type: Class
subclass of: Little toe
imported from: fma.owl
has_obo_namespace: fma
id: FMA:60343

Left little toe
type: Class
subclass of: Little toe
imported from: fma.owl
has_obo_namespace: fma
id: FMA:60344

Physical anatomical entity
type: Class
subclass of: Anatomical entity
textual definition: Anatomical entity which has three or fewer spatial dimensions. Examples: hemoglobin molecule, mitochondrion, hepatocyte, erythrocyte, heart, head, blood, urine, peritoneal cavity, diaphragmatic surface of heart, inferior margin of liver, apex of lung.
imported from: fma.owl
has_obo_namespace: fma
id: FMA:61775

Anatomical entity
type: Class
subclass of: melanoma ontology
textual definition: Organismal continuant entity which is enclosed by the bona fide boundary of an organism or is an attribute of its structural organization. Examples: cell, heart, head, peritoneal cavity, apex of lung, anatomical term, sagittal plane.
imported from: fma.owl
has_obo_namespace: fma
id: FMA:62955

Mucosa of esophagus
type: Class
subclass of: Mucosa
imported from: fma.owl
has exact synonym: Esophageal mucosa
has exact synonym: Esophagus mucosa
has exact synonym: Mucous membrane of oesophagus
has exact synonym: Muscularis mucosae of oesophagus
has exact synonym: Oesophageal mucosa
has_obo_namespace: fma
id: FMA:62996

Anatomical structure
type: Class
subclass of: Physical anatomical entity
textual definition: Material anatomical entity which is generated by coordinated expression of the organism's own genes that guide its morphogenesis; has inherent 3D shape; its parts are connected and spatially related to one another in patterns determined by coordinated gene expression. Examples: heart, right ventricle, mitral valve, myocardium, endothelium, lymphocyte, fibroblast, thorax, cardiovascular system, hemoglobin, T cell receptor.
imported from: fma.owl
has exact synonym: Biological structure
has_obo_namespace: fma
id: FMA:67135

Organ
type: Class
subclass of: Anatomical structure
textual definition: Anatomical structure which has as its direct parts portions of two or more types of tissue or two or more types of cardinal organ part which constitute a maximally connected anatomical structure demarcated predominantly by a bona fide anatomical surface. Examples: femur, biceps, liver, heart, skin, tracheobronchial tree, ovary.
imported from: fma.owl
has_obo_namespace: fma
id: FMA:67498

Subdivision of cardinal body part
type: Class
subclass of: Anatomical structure
textual definition: Anatomical structure, which is a subdivision of a cardinal body part; it may exclude bones; is demarcated from other subdivisions of the same cardinal body part by anatomical surfaces or lines or topographical references; together with other contiguous subdivisions of the same cardinal body part, it constitutes a cardinal body part. Examples: thorax, perineum, back of neck, forearm, hand, phalanx, nose, auricle of ear, scrotum.
imported from: fma.owl
has exact synonym: Principal body part subdivision
has_obo_namespace: fma
id: FMA:67504

Anatomical cavity
type: Class
subclass of: Anatomical space
textual definition: Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina.
imported from: fma.owl
has_obo_namespace: fma
id: FMA:67552

Esophagus
type: Class
subclass of: Organ with organ cavity
textual definition: Organ with organ cavity which is continuous superiorly with the pharynx and inferiorly with the stomach. Examples: There is only one esophagus.
imported from: fma.owl
has exact synonym: Gullet
has_obo_namespace: fma
id: FMA:7131

Stomach
type: Class
subclass of: Organ with organ cavity
textual definition: Organ with organ cavity which is continuous proximally with the esophagus and distally with the small intestine. Examples: There is only one stomach.
imported from: fma.owl
has_obo_namespace: fma
id: FMA:7148

Neck
type: Class
subclass of: Subdivision of body proper
textual definition: Subdivision of body proper, which consists of a maximal set of diverse subclasses of organ and organ part spatially associated with the cervical vertebral coumn, it is partially surrounded by skin of neck. Examples: There is only one neck.
imported from: fma.owl
has exact synonym: Neck (volume)
has_obo_namespace: fma
id: FMA:7155

Skin
type: Class
subclass of: Nonparenchymatous organ
textual definition: Nonparenchymatous organ that consists of the epidermis, dermis and sets of hair and nails and which surrounds the entire body. Subdivisions of the skin surround various body parts; as a whole, the skin constitutes the external layer of the body. Examples: There is only one skin.
imported from: fma.owl
has exact synonym: Skin of body
has_obo_namespace: fma
id: FMA:7163

Small intestine
type: Class
subclass of: Organ with organ cavity
textual definition: Organ with organ cavity which is continuous proximally with the stomach and distally with the large intestine. Examples: There is only one small intestine.
imported from: fma.owl
has exact synonym: Small bowel
has_obo_namespace: fma
id: FMA:7200

Large intestine
type: Class
subclass of: Organ with organ cavity
textual definition: Organ with organ cavity which is continuous proximally with the small intestine and distally with the anal canal. Examples: There is only large intestine.
imported from: fma.owl
has exact synonym: Large bowel
has_obo_namespace: fma
id: FMA:7201

Plantar
type: Class
subclass of: Anatomical entity
imported from: fma.owl
has_obo_namespace: fma
id: FMA:74560

Mucosa of anal canal
type: Class
subclass of: Mucosa
imported from: fma.owl
has exact synonym: Anal canal mucosa
has exact synonym: Anal mucosa
has exact synonym: Anal mucous membrane
has exact synonym: Mucous membrane of anal canal
has_obo_namespace: fma
id: FMA:74654

Cardinal organ part
type: Class
subclass of: Anatomical structure
textual definition: anatomical structure which has as its direct parts two or more types of tissue and is continuous with one or more anatomical structures likewise constituted by two or more portions of tissues distinct from those of their complement. Examples: osteon, cortical bone, neck of femur, bronchopulmonary segment, left lobe of liver, anterior right side of heart, interventricular branch of left coronary artery, right atrium, mitral valve, head of pancreas.
imported from: fma.owl
has_obo_namespace: fma
id: FMA:82472

Organ component layer
type: Class
subclass of: Organ component
imported from: fma.owl
has_obo_namespace: fma
id: FMA:82485

Mucosa
type: Class
subclass of: Organ component layer
imported from: fma.owl
has exact synonym: Mucosa of organ
has exact synonym: Mucous membrane
has exact synonym: Organ mucosa
has_obo_namespace: fma
id: FMA:85355

Viscerocranial mucosa organ part
type: Class
subclass of: Cardinal organ part
imported from: fma.owl
has_obo_namespace: fma
id: FMA:85361

Thorax
type: Class
subclass of: Subdivision of trunk proper
textual definition: Subdivision of trunk proper, which is demarcated from the neck by the plane of the superior thoracic aperture and from the abdomen internally by the inferior surface of the diaphragm and externally by the costal margin and associated with the thoracic vertebral column and ribcage and from the back of the thorax by the external surface of the posterolateral part of the rib cage, the anterior surface of the thoracic vertebral column and the posterior axillary lines; together with the abdomen and the perineum, it constitutes the trunk proper. Examples: There is only one thorax.
imported from: fma.owl
has exact synonym: Chest
has_obo_namespace: fma
id: FMA:9576

Abdomen
type: Class
subclass of: Subdivision of trunk proper
textual definition: Subdivision of trunk proper, which is demarcated from the thorax internally by the inferior surface of the sternocostal part of the diaphragm and externally by the costal margin, from the back of abdomen by the external surface of the posterior abdominal wall, from the perineum by the superior surface of the urogenital diaphragm and from the lower limbs by the inguinal folds; together with the thorax, and perineum, it constitutes the trunk proper. Examples: There is only one abdomen.
imported from: fma.owl
has exact synonym: Abdominopelvic region
has exact synonym: Abdominopelvis
has_obo_namespace: fma
id: FMA:9577

Pia mater
type: Class
subclass of: Nonparenchymatous organ
imported from: fma.owl
has exact synonym: Pia mater of neuraxis
has_obo_namespace: fma
id: FMA:9590

Finger
type: Class
subclass of: Free limb segment
textual definition: Subdivision of the hand demarcated from the hand proper by the skin crease in line with the distal edge of finger webs. Examples: thumb, right middle finger, left little finger.
imported from: fma.owl
has exact synonym: Digit of hand
has exact synonym: Digitus manus
has_obo_namespace: fma
id: FMA:9666

Phenotypic abnormality
type: Class
subclass of: melanoma ontology
textual definition: A phenotypic abnormality.
imported from: hp.owl
database_cross_reference: UMLS:C4021819
has exact synonym: Organ abnormality
has_obo_namespace: human_phenotype
id: HP:0000118
comment: This is the root of the phenotypic abnormality subontology of the HPO.

Abnormality of the nose
type: Class
subclass of: Phenotypic abnormality
textual definition: An abnormality of the nose.
imported from: hp.owl
database_cross_reference: SNOMEDCT_US:128274005
database_cross_reference: SNOMEDCT_US:72089000
database_cross_reference: UMLS:C0240547
database_cross_reference: UMLS:C0265736
database_cross_reference: UMLS:C2235909
has exact synonym: Abnormality of the nose
has exact synonym: Anomaly of the nose
has exact synonym: Nasal abnormality
has exact synonym: Nasal anomaly
has_narrow_synonym: Deformity of the nose
has_narrow_synonym: Malformation of the nose
has_narrow_synonym: Nasal deformity
has_narrow_synonym: Nasal malformation
has_obo_namespace: human_phenotype
id: HP:0000366
in subset: hposlim core

Epistaxis
type: Class
subclass of: Abnormality of the nose
subclass of: Abnormal bleeding
textual definition: Epistaxis, or nosebleed, refers to a hemorrhage localized in the nose.
imported from: hp.owl
database_cross_reference: COHD:318556
database_cross_reference: EFO:0003895
database_cross_reference: ICD10:R04.0
database_cross_reference: ICD9:784.7
database_cross_reference: MSH:D004844
database_cross_reference: NCIT:C26766
database_cross_reference: SNOMEDCT_US:12441001
database_cross_reference: SNOMEDCT_US:249366005
database_cross_reference: UMLS:C0014591
has exact synonym: Bloody nose
has exact synonym: Frequent nosebleeds
has exact synonym: Nasal hemorrhage
has exact synonym: Nose bleed
has exact synonym: Nose bleeding
has exact synonym: Nosebleed
has_obo_namespace: human_phenotype
id: HP:0000421

Abnormality of the eye
type: Class
subclass of: Phenotypic abnormality
textual definition: Any abnormality of the eye, including location, spacing, and intraocular abnormalities.
imported from: hp.owl
database_cross_reference: MSH:D005124
database_cross_reference: MSH:D005128
database_cross_reference: SNOMEDCT_US:19416009
database_cross_reference: SNOMEDCT_US:371405004
database_cross_reference: SNOMEDCT_US:371409005
database_cross_reference: UMLS:C0015393
database_cross_reference: UMLS:C0015397
has exact synonym: Abnormal eye
has exact synonym: Abnormality of the eye
has_obo_namespace: human_phenotype
has_related_synonym: Eye disease
id: HP:0000478
in subset: hposlim core

Abnormality of vision
type: Class
subclass of: Abnormality of the eye
textual definition: Abnormality of eyesight (visual perception).
imported from: hp.owl
database_cross_reference: UMLS:C4025846
has exact synonym: Abnormality of sight
has exact synonym: Abnormality of vision
has exact synonym: Vision issue
has_obo_namespace: human_phenotype
id: HP:0000504
in subset: hposlim core

Visual impairment
type: Class
subclass of: Abnormality of vision
textual definition: Visual impairment (or vision impairment) is vision loss (of a person) to such a degree as to qualify as an additional support need through a significant limitation of visual capability resulting from either disease, trauma, or congenital or degenerative conditions that cannot be corrected by conventional means, such as refractive correction, medication, or surgery.
imported from: hp.owl
has_alternative_id: HP:0000516
has_alternative_id: HP:0000566
has_alternative_id: HP:0007758
has_alternative_id: HP:0007860
has_alternative_id: HP:0007983
database_cross_reference: MSH:D014786
database_cross_reference: MSH:D015354
database_cross_reference: SNOMEDCT_US:246635007
database_cross_reference: SNOMEDCT_US:397540003
database_cross_reference: SNOMEDCT_US:7973008
database_cross_reference: UMLS:C0042798
database_cross_reference: UMLS:C3665347
has exact synonym: Impaired vision
has exact synonym: Loss of eyesight
has exact synonym: Poor vision
has exact synonym: Visual impairment
has_obo_namespace: human_phenotype
id: HP:0000505
in subset: hposlim core

Visual loss
type: Class
subclass of: Visual impairment
textual definition: Loss of visual acuity (implying that vision was better at a certain timepoint in life). Otherwise the term reduced visual acuity should be used (or a subclass of that).
imported from: hp.owl
database_cross_reference: SNOMEDCT_US:7973008
database_cross_reference: UMLS:C3665386
has exact synonym: Loss of vision
has exact synonym: Vision loss
has exact synonym: Visual loss
has_obo_namespace: human_phenotype
id: HP:0000572

Abnormal pupil morphology
type: Class
subclass of: Abnormality of the eye
textual definition: An abnormality of the pupil.
imported from: hp.owl
has_alternative_id: HP:0008018
has_alternative_id: HP:0030960
database_cross_reference: SNOMEDCT_US:274093008
database_cross_reference: UMLS:C0154936
has exact synonym: Abnormal pupillary morphology
has exact synonym: Abnormality of the pupil
has exact synonym: Pupillary abnormalities
has exact synonym: Pupillary abnormality
has_obo_namespace: human_phenotype
id: HP:0000615
in subset: hposlim core

Blindness
type: Class
subclass of: Reduced visual acuity
textual definition: Blindness is the condition of lacking visual perception defined as visual perception below 3/60 and/or a visual field of no greater than 10 degress in radius around central fixation.
imported from: hp.owl
has_alternative_id: HP:0007839
database_cross_reference: Fyler:4866
database_cross_reference: MSH:D001766
database_cross_reference: SNOMEDCT_US:65956007
database_cross_reference: UMLS:C0271215
database_cross_reference: UMLS:C0456909
has exact synonym: Blindness
has exact synonym: Total vision loss
has_obo_namespace: human_phenotype
has_related_synonym: Legal blindness
id: HP:0000618
in subset: hposlim core
comment: Various scales have been developed to describe the extent of vision loss and define blindness. Total blindness is the complete lack of form and visual light perception and is clinically recorded as NLP (no light perception). Blindness is frequently used to describe severe visual impairment with residual vision. Those described as having only light perception have no more sight than the ability to tell light from dark and the general direction of a light source.

Blurred vision
type: Class
subclass of: Abnormality of vision
textual definition: Lack of sharpness of vision resulting in the inability to see fine detail.
imported from: hp.owl
has_alternative_id: HP:0007723
database_cross_reference: SNOMEDCT_US:111516008
database_cross_reference: SNOMEDCT_US:246636008
database_cross_reference: UMLS:C0344232
has exact synonym: Blurred vision
has_obo_namespace: human_phenotype
id: HP:0000622
in subset: hposlim core
comment: This is a very nonspecific term and it is preferable to describe the correlates of blurred vision with the corresponding terms if possible.

Amblyopia
type: Class
subclass of: Reduced visual acuity
textual definition: Reduced visual acuity that is uncorrectable by lenses in the absence of detectable anatomic defects in the eye or visual pathways.
imported from: hp.owl
database_cross_reference: MSH:D000550
database_cross_reference: SNOMEDCT_US:387742006
database_cross_reference: UMLS:C0002418
has exact synonym: Lazy eye
has exact synonym: Wandering eye
has exact synonym: Wandering eyes
has_obo_namespace: human_phenotype
id: HP:0000646
in subset: hposlim core
comment: Ambylopia can result from visual deprivation during the critical period of development of visual abilities which lasts to about the age of 8 years. Thus, ambylopia can result from strabismus, anisometropia, or high hypermetropia in there is a failure to form a focused image in one or both eyes.

Abnormality of the skin
type: Class
subclass of: Phenotypic abnormality
textual definition: An abnormality of the skin.
imported from: hp.owl
has_alternative_id: HP:0001478
has_alternative_id: HP:0001479
has_alternative_id: HP:0005591
has_alternative_id: HP:0006736
has_alternative_id: HP:0007415
has_alternative_id: HP:0007580
database_cross_reference: MSH:D012868
database_cross_reference: MSH:D012871
database_cross_reference: SNOMEDCT_US:199879009
database_cross_reference: SNOMEDCT_US:95320005
database_cross_reference: UMLS:C0037268
database_cross_reference: UMLS:C0037274
has exact synonym: Abnormality of the skin
has exact synonym: dermatopathy
has exact synonym: dermopathy
has_obo_namespace: human_phenotype
has_related_synonym: Skin abnormality
id: HP:0000951
in subset: hposlim core

Pruritus
type: Class
subclass of: Abnormality of the skin
textual definition: Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased disposition to experience pruritus.
imported from: hp.owl
database_cross_reference: MSH:D011537
database_cross_reference: SNOMEDCT_US:279333002
database_cross_reference: SNOMEDCT_US:418290006
database_cross_reference: SNOMEDCT_US:418363000
database_cross_reference: SNOMEDCT_US:424492005
database_cross_reference: UMLS:C0033774
has exact synonym: Itching
has exact synonym: Itchy skin
has exact synonym: Skin itching
has exact synonym: pruritis
has_obo_namespace: human_phenotype
id: HP:0000989
in subset: hposlim core

Melanocytic nevus
type: Class
subclass of: Nevus
subclass of: Abnormality of skin morphology
textual definition: A oval and round, colored (usually medium-to dark brown, reddish brown, or flesh colored) lesion. Typically, a melanocytic nevus is less than 6 mm in diameter, but may be much smaller or larger.
imported from: hp.owl
has_broad_synonym: Noncancerous mole
database_cross_reference: MSH:D009508
database_cross_reference: SNOMEDCT_US:21119008
database_cross_reference: SNOMEDCT_US:400096001
database_cross_reference: UMLS:C0027962
database_cross_reference: UMLS:C4280269
has exact synonym: Beauty mark
has exact synonym: Melanocytic naevus
has exact synonym: Melanocytic nevi
has exact synonym: Nevocellular nevi
has exact synonym: Pigmented naevi
has exact synonym: Pigmented nevi
has_obo_namespace: human_phenotype
id: HP:0000995
comment: Melanocytic nevi are commonly known as moles. The majority of moles appear during the first 20 to 30 years of a person's life, however, some may be present when the baby is born. The average human has from 10 to 14 moles. Moles can develop on the scalp, under the nails, armpits, virtually anywhere on the body. The total number of moles a person can have usually varies during his or her lifetime.

Sudden loss of visual acuity
type: Class
subclass of: Reduced visual acuity
textual definition: Severe loss of visual acuity within hours or days. This is characteristic of Leber hereditary optic neuropathy.
imported from: hp.owl
has_broad_synonym: Sudden decrease in vision
database_cross_reference: UMLS:C4025803
database_cross_reference: UMLS:C4072828
database_cross_reference: UMLS:C4280600
has_obo_namespace: human_phenotype
has_related_synonym: Sudden central visual loss
id: HP:0001117

Visual field defect
type: Class
subclass of: Visual impairment
imported from: hp.owl
database_cross_reference: SNOMEDCT_US:12184005
database_cross_reference: UMLS:C3887875
has exact synonym: Partial loss of field of vision
has exact synonym: Visual field defects
has_obo_namespace: human_phenotype
id: HP:0001123

Constriction of peripheral visual field
type: Class
subclass of: Visual field defect
textual definition: An absolute or relative decrease in retinal sensitivity extending from edge (periphery) of the visual field in a concentric pattern. The visual field is the area that is perceived simultaneously by a fixating eye.
imported from: hp.owl
has_alternative_id: HP:0007887
has_alternative_id: HP:0007981
database_cross_reference: SNOMEDCT_US:1151008
database_cross_reference: SNOMEDCT_US:267628004
database_cross_reference: UMLS:C0235095
has exact synonym: Concentric narrowing of visual field
has exact synonym: Constricted visual field
has exact synonym: Constricted visual fields
has exact synonym: Limited peripheral vision
has exact synonym: Visual field constriction
has_obo_namespace: human_phenotype
id: HP:0001133

Severely reduced visual acuity
type: Class
subclass of: Reduced visual acuity
textual definition: Severe reduction of the ability to see defined as visual acuity less than 6/60 (20/200 in US notation; 0.1 in decimal notation) but at least 3/60 (20/400 in US notation; 0.05 in decimal notation).
imported from: hp.owl
has_alternative_id: HP:0007640
has_alternative_id: HP:0007842
has_alternative_id: HP:0007951
has_alternative_id: HP:0008023
database_cross_reference: SNOMEDCT_US:397541004
database_cross_reference: UMLS:C1301509
has exact synonym: Marked vision impairment
has exact synonym: Severe reduction in visual acuity
has exact synonym: Severe vision loss
has exact synonym: Severe visual impairment
has exact synonym: Severe visual loss
has exact synonym: Severely impaired vision
has_obo_namespace: human_phenotype
id: HP:0001141

Abnormality of the cardiovascular system
type: Class
subclass of: Phenotypic abnormality
textual definition: Any abnormality of the cardiovascular system.
imported from: hp.owl
database_cross_reference: MSH:D002318
database_cross_reference: MSH:D018376
database_cross_reference: SNOMEDCT_US:49601007
database_cross_reference: UMLS:C0007222
database_cross_reference: UMLS:C0243050
has exact synonym: Abnormality of the cardiovascular system
has exact synonym: Cardiovascular abnormality
has_obo_namespace: human_phenotype
has_related_synonym: Cardiovascular disease
id: HP:0001626
comment: The cardiovascular system consists of the heart, vasculature, and the lymphatic system.

Nasal obstruction
type: Class
subclass of: Abnormality of the nose
textual definition: Reduced ability to pass air through the nasal cavity often leading to mouth breathing.
imported from: hp.owl
database_cross_reference: MSH:D015508
database_cross_reference: SNOMEDCT_US:232209000
database_cross_reference: SNOMEDCT_US:267100006
database_cross_reference: SNOMEDCT_US:68235000
database_cross_reference: UMLS:C0027424
database_cross_reference: UMLS:C0027429
has exact synonym: Blockage of nose
has exact synonym: Nasal blockage
has exact synonym: Nasal obstruction
has exact synonym: Obstruction of nose
has exact synonym: Stuffy nose
has_narrow_synonym: Congestion of nose
has_narrow_synonym: Nasal congestion
has_obo_namespace: human_phenotype
id: HP:0001742

Abnormal bleeding
type: Class
subclass of: Phenotypic abnormality
textual definition: An abnormal susceptibility to bleeding, often referred to as a bleeding diathesis. A bleeding diathesis may be related to vascular, platelet and coagulation defects.
imported from: hp.owl
has_alternative_id: HP:0004830
has_alternative_id: HP:0004834
has_alternative_id: HP:0004849
has_alternative_id: HP:0004862
has_alternative_id: HP:0004865
has_alternative_id: HP:0008183
database_cross_reference: SNOMEDCT_US:248250000
database_cross_reference: SNOMEDCT_US:64779008
database_cross_reference: UMLS:C1458140
has exact synonym: Bleeding diathesis
has exact synonym: Bleeding tendency
has exact synonym: Hemorrhagic diathesis
has_obo_namespace: human_phenotype
id: HP:0001892
comment: This term is kept for historical reasons. If possible, a more exact description of the phenotype (i.e., whether there is a vascular, platelet and coagulation defect) should be attempted.

Subcutaneous hemorrhage
type: Class
subclass of: Abnormal bleeding
subclass of: Vascular skin abnormality
textual definition: This term refers to an abnormally increased susceptibility to bruising (purpura, petechiae, or ecchymoses).
imported from: hp.owl
created_by: peter
creation_date: 2008-02-28T07:14:00Z
database_cross_reference: UMLS:C0854107
has exact synonym: Bleeding below the skin
has exact synonym: Subcutaneous haemorrhage
has_obo_namespace: human_phenotype
id: HP:0001933
comment: Purpura measure 0.3-1 cm (3-10 mm), whereas petechiae measure less than 3 mm, and ecchymoses greater than 1 cm.

Abnormality of the respiratory system
type: Class
subclass of: Phenotypic abnormality
textual definition: An abnormality of the respiratory system, which include the airways, lungs, and the respiratory muscles.
imported from: hp.owl
database_cross_reference: UMLS:C4018871
has exact synonym: Respiratory abnormality
has_obo_namespace: human_phenotype
id: HP:0002086

Hemoptysis
type: Class
subclass of: Abnormality of the respiratory system
textual definition: Coughing up (expectoration) of blood or blood-streaked sputum from the larynx, trachea, bronchi, or lungs.
imported from: hp.owl
database_cross_reference: MSH:D006469
database_cross_reference: SNOMEDCT_US:66857006
database_cross_reference: SNOMEDCT_US:6686005
database_cross_reference: UMLS:C0019079
has exact synonym: Coughing up blood
has exact synonym: Haemoptysis
has_obo_namespace: human_phenotype
has_related_synonym: Coughing up blood or blood-stained mucus
id: HP:0002105

Gastrointestinal hemorrhage
type: Class
subclass of: Internal hemorrhage
subclass of: Functional abnormality of the gastrointestinal tract
textual definition: Hemorrhage affecting the gastrointestinal tract.
imported from: hp.owl
database_cross_reference: MSH:D006471
database_cross_reference: SNOMEDCT_US:74474003
database_cross_reference: UMLS:C0017181
has exact synonym: GI hemorrhage
has exact synonym: Gastrointestinal bleeding
has exact synonym: Gastrointestinal haemorrhage
has_obo_namespace: human_phenotype
id: HP:0002239

Hematochezia
type: Class
subclass of: Gastrointestinal hemorrhage
subclass of: Abnormality of digestive system physiology
textual definition: The passage of fresh (red) blood per anus, usually in or with stools. Most rectal bleeding comes from the colon, rectum, or anus.
imported from: hp.owl
has_alternative_id: HP:0002255
has_alternative_id: HP:0002609
database_cross_reference: MSH:D006471
database_cross_reference: SNOMEDCT_US:236068001
database_cross_reference: SNOMEDCT_US:405729008
database_cross_reference: UMLS:C0018932
has exact synonym: Rectal bleeding
has_obo_namespace: human_phenotype
has_related_synonym: Recurrent rectal bleeding
id: HP:0002573
comment: Bright red blood in stool, most frequentoly caused by hemorrhoids or diverticulosis.

Nevus
type: Class
subclass of: Abnormality of skin morphology
textual definition: A nevus is a type of hamartoma that is a circumscribed stable malformation of the skin.
imported from: hp.owl
database_cross_reference: MSH:D009506
database_cross_reference: MSH:D009508
database_cross_reference: SNOMEDCT_US:21119008
database_cross_reference: SNOMEDCT_US:400096001
database_cross_reference: SNOMEDCT_US:51697005
database_cross_reference: UMLS:C0027960
database_cross_reference: UMLS:C0027962
has exact synonym: Mole
has exact synonym: Naevus
has_obo_namespace: human_phenotype
has_related_synonym: Naevi
has_related_synonym: Nevi
id: HP:0003764
comment: The word Nevus derives from the Latin word Knee-vus meaning birthmark or mole.

Intestinal obstruction
type: Class
subclass of: Morphological abnormality of the gastrointestinal tract
subclass of: Functional abnormality of the gastrointestinal tract
textual definition: Blockage or impairment of the normal flow of the contents of the intestine towards the anal canal.
imported from: hp.owl
has_alternative_id: HP:0005239
database_cross_reference: MSH:D007415
database_cross_reference: SNOMEDCT_US:81060008
database_cross_reference: UMLS:C0021843
has exact synonym: Bowel obstruction
has exact synonym: Intestinal blockage
has exact synonym: Intestinal obstruction
has_obo_namespace: human_phenotype
id: HP:0005214

Congenital giant melanocytic nevus
type: Class
subclass of: Melanocytic nevus
textual definition: The giant congenital nevus is greater than 8 cm in size, pigmented and often hairy. A giant congenital nevus is smaller in infants and children, but it usually continues to grow with the child.
imported from: hp.owl
has_alternative_id: HP:0005604
database_cross_reference: MSH:C536819
database_cross_reference: SNOMEDCT_US:10291008
database_cross_reference: SNOMEDCT_US:254815002
database_cross_reference: UMLS:C1842036
has exact synonym: Giant pigmented hairy nevus
has exact synonym: Giant pigmented mole
has exact synonym: Giant pigmented nevus
has_obo_namespace: human_phenotype
id: HP:0005600
comment: Between 4% and 6% of these lesions will develop into a malignant melanoma.

Numerous congenital melanocytic nevi
type: Class
subclass of: Melanocytic nevus
imported from: hp.owl
database_cross_reference: UMLS:C3806415
has_obo_namespace: human_phenotype
id: HP:0005603

Hyperpigmented nevi and streak
type: Class
subclass of: Melanocytic nevus
imported from: hp.owl
database_cross_reference: UMLS:C3805692
has_obo_namespace: human_phenotype
id: HP:0005606

Hyperpigmented nevi
type: Class
subclass of: Melanocytic nevus
imported from: hp.owl
database_cross_reference: UMLS:C0746889
has_obo_namespace: human_phenotype
id: HP:0007481

Reduced visual acuity
type: Class
subclass of: Visual impairment
imported from: hp.owl
has_alternative_id: HP:0001091
has_alternative_id: HP:0007693
has_alternative_id: HP:0007739
has_alternative_id: HP:0007969
has_alternative_id: HP:0008008
database_cross_reference: SNOMEDCT_US:13164000
database_cross_reference: UMLS:C0234632
has exact synonym: Decreased central vision
has exact synonym: Decreased clarity of vision
has exact synonym: Decreased visual acuity
has exact synonym: Poor visual acuity
has_obo_namespace: human_phenotype
id: HP:0007663

Congenital blindness
type: Class
subclass of: Blindness
textual definition: Blindness with onset at birth.
imported from: hp.owl
has_alternative_id: HP:0007706
database_cross_reference: SNOMEDCT_US:95486002
database_cross_reference: UMLS:C0005754
has exact synonym: Blindness present at birth
has exact synonym: Congenital amaurosis
has_obo_namespace: human_phenotype
id: HP:0007875

Progressive visual field defects
type: Class
subclass of: Visual field defect
imported from: hp.owl
database_cross_reference: UMLS:C4024760
has_obo_namespace: human_phenotype
id: HP:0007987

Peripheral visual field loss
type: Class
subclass of: Constriction of peripheral visual field
textual definition: Loss of peripheral vision with retention of central vision, resulting in a constricted circular tunnel-like field of vision.
imported from: hp.owl
database_cross_reference: SNOMEDCT_US:420990001
database_cross_reference: UMLS:C0241688
database_cross_reference: UMLS:C2937228
has exact synonym: Kalnienk vision
has exact synonym: Loss of peripheral vision
has_obo_namespace: human_phenotype
has_related_synonym: Tunnel vision
id: HP:0007994

Abnormality of the gastrointestinal tract
type: Class
subclass of: Abnormality of the digestive system
textual definition: An abnormality of the gastrointestinal tract.
imported from: hp.owl
created_by: peter
creation_date: 2011-03-01T07:52:06Z
database_cross_reference: MSH:D004066
database_cross_reference: MSH:D005767
database_cross_reference: SNOMEDCT_US:119292006
database_cross_reference: SNOMEDCT_US:25374005
database_cross_reference: SNOMEDCT_US:53619000
database_cross_reference: UMLS:C0012242
database_cross_reference: UMLS:C0017178
database_cross_reference: UMLS:C4023588
has exact synonym: Abnormality of the GI tract
has exact synonym: Abnormality of the gastrointestinal tract
has_obo_namespace: human_phenotype
has_related_synonym: Digestive system disease
has_related_synonym: Gastrointestinal disease
id: HP:0011024

Internal hemorrhage
type: Class
subclass of: Abnormality of the cardiovascular system
subclass of: Abnormal bleeding
textual definition: The presence of hemorrhage within the body.
imported from: hp.owl
created_by: peter
creation_date: 2011-03-03T10:26:26Z
database_cross_reference: UMLS:C1390214
has exact synonym: Internal bleeding
has exact synonym: Internal haemorrhage
has_obo_namespace: human_phenotype
id: HP:0011029

Abnormality of skin morphology
type: Class
subclass of: Abnormality of the skin
textual definition: Any morphological abnormality of the skin.
imported from: hp.owl
created_by: peter
creation_date: 2011-06-12T10:03:23Z
database_cross_reference: Fyler:4133
database_cross_reference: UMLS:C4023528
has exact synonym: Abnormal skin morphology
has exact synonym: Abnormal skin structure
has_obo_namespace: human_phenotype
id: HP:0011121

Vascular skin abnormality
type: Class
subclass of: Abnormality of the cardiovascular system
subclass of: Abnormality of skin morphology
imported from: hp.owl
created_by: peter
creation_date: 2011-12-29T08:52:53Z
database_cross_reference: MSH:D017445
database_cross_reference: SNOMEDCT_US:11263005
database_cross_reference: UMLS:C0162819
database_cross_reference: UMLS:C1842892
has exact synonym: Skin vascular malformation
has_obo_namespace: human_phenotype
has_related_synonym: Vascular abnormalities restricted to skin
id: HP:0011276

Pain
type: Class
subclass of: Phenotypic abnormality
textual definition: An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage.
imported from: hp.owl
created_by: peter
creation_date: 2013-12-15T09:38:08Z
database_cross_reference: MSH:D010146
database_cross_reference: SNOMEDCT_US:22253000
database_cross_reference: UMLS:C0030193
has exact synonym: Pain
has_obo_namespace: human_phenotype
id: HP:0012531

Morphological abnormality of the gastrointestinal tract
type: Class
subclass of: Abnormality of the gastrointestinal tract
subclass of: Abnormality of the digestive system
textual definition: Abnormal structure of the gastrointestinal tract.
imported from: hp.owl
created_by: peter
creation_date: 2014-03-23T01:09:02Z
database_cross_reference: UMLS:C4021073
has exact synonym: Abnormal shape of the digestive system
has exact synonym: Morphological abnormality of the GI tract
has exact synonym: Morphological anomaly of the digestive system
has_obo_namespace: human_phenotype
id: HP:0012718

Functional abnormality of the gastrointestinal tract
type: Class
subclass of: Abnormality of the gastrointestinal tract
subclass of: Abnormality of digestive system physiology
textual definition: Abnormal functionality of the gastrointestinal tract.
imported from: hp.owl
created_by: peter
creation_date: 2014-03-23T01:10:47Z
database_cross_reference: UMLS:C4022755
has exact synonym: Functional abnormality of the GI tract
has exact synonym: GI dysfunction
has_obo_namespace: human_phenotype
id: HP:0012719

Cough
type: Class
subclass of: Abnormality of the respiratory system
textual definition: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation.
imported from: hp.owl
created_by: peter
creation_date: 2014-03-23T03:19:50Z
database_cross_reference: MSH:D003371
database_cross_reference: SNOMEDCT_US:263731006
database_cross_reference: SNOMEDCT_US:272039006
database_cross_reference: SNOMEDCT_US:49727002
database_cross_reference: UMLS:C0010200
has exact synonym: Cough
has exact synonym: Coughing
has_obo_namespace: human_phenotype
id: HP:0012735
comment: The European Respiratory Society Task Force recommended two possible definitions of cough: (1) A three-phase expulsive motor act characterized by an inspiratory effort (inspiratory phase) followed by a forced expiratory effort against a closed glottis (compressive phase) and then by opening of the glottis and rapid expiratory airflow (expulsive phase);and (2) A forced expiratory manoeuvre, usually against a closed glottis and associated with a characteristic sound. The term Cough or any of its more specific descendents can be modified by the terms Acute (HP:0011009), Subacute (HP:0011011), and Chronic (HP:0011010). There is agreement that an actue cough lasts less than 3 weeks, a subacute cough from 3 to 8 weeks, and a chronic cough longer than 8 weeks.

Abnormality of the digestive system
type: Class
subclass of: Phenotypic abnormality
imported from: hp.owl
date: 2016-08-27T13:44:32Z
created_by: HPO:probinson
comment: Any anomaly of the digestive system, a collection of organs that is made up of the gastrointestinal tract and the liver, pancreas, and gallbladder. The gastrointestinal tract is a series of hollow organs joined in a long, twisting tube from the mouth to the anus, including the mouth, esophagus, stomach, small intestine, large intestine and anus.

Abnormality of digestive system physiology
type: Class
subclass of: Abnormality of the digestive system
textual definition: A functional anomaly of the digestive system.
imported from: hp.owl
date: 2016-08-27T13:58:05Z
created_by: HPO:probinson

Moderately reduced visual acuity
type: Class
subclass of: Reduced visual acuity
textual definition: Moderate reduction of the ability to see defined as visual acuity less than 6/18 (20/60 in US notation; 0.5 in decimal notation) but at least 6/60 (20/200 in US notation; 0.1 in decimal notation).
imported from: hp.owl
database_cross_reference: SNOMEDCT_US:397542006
database_cross_reference: UMLS:C1301510
has exact synonym: Moderate reduction in visual acuity
has exact synonym: Moderate vision loss
has exact synonym: Moderate visual impairment
has exact synonym: Moderate visual loss

Mild constriction of peripheral visual field
type: Class
subclass of: Constriction of peripheral visual field
textual definition: A diminution of the peripheral visual field whereby at least 50 degrees of central field are preserved in all meridians.
imported from: hp.owl
database_cross_reference: UMLS:C4072999
has exact synonym: Mild peripheral visual field loss

Moderate constriction of peripheral visual field
type: Class
subclass of: Constriction of peripheral visual field
textual definition: Peripheral visual field constriction with 20-49 degrees binocular visual field preserved.
imported from: hp.owl
has_alternative_id: HP:0030523
has_alternative_id: HP:0030524
database_cross_reference: UMLS:C4073002
has exact synonym: Moderate peripheral visual field loss

Severe constriction of peripheral visual field
type: Class
subclass of: Constriction of peripheral visual field
textual definition: Peripheral visual field constriction with 10-19 degrees central field preserved.
imported from: hp.owl
database_cross_reference: UMLS:C4073003
has exact synonym: Severe peripheral visual field loss

Very severe constriction of peripheral visual field
type: Class
subclass of: Constriction of peripheral visual field
textual definition: Peripheral visual field constriction with <10 degrees central field preserved.
imported from: hp.owl
database_cross_reference: UMLS:C4073004
has exact synonym: Very severe peripheral visual field loss

Altitudinal visual field defect
type: Class
subclass of: Visual field defect
imported from: hp.owl
database_cross_reference: UMLS:C4073005

Visual acuity test abnormality
type: Class
subclass of: Reduced visual acuity
imported from: hp.owl
database_cross_reference: UMLS:C4073006

Abnormal unaided visual acuity test
type: Class
subclass of: Visual acuity test abnormality
imported from: hp.owl
database_cross_reference: UMLS:C4073007

Abnormal best corrected visual acuity test
type: Class
subclass of: Visual acuity test abnormality
imported from: hp.owl
database_cross_reference: UMLS:C4073008

Abnormal pinhole visual acuity test
type: Class
subclass of: Visual acuity test abnormality
imported from: hp.owl
database_cross_reference: UMLS:C4073009

Unaided visual acuity 0.1 LogMAR
type: Class
subclass of: Abnormal unaided visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073010

Unaided visual acuity 0.2 LogMAR
type: Class
subclass of: Abnormal unaided visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073011

Unaided visual acuity 0.3 LogMAR
type: Class
subclass of: Abnormal unaided visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073012

Unaided visual acuity 0.4 LogMAR
type: Class
subclass of: Abnormal unaided visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073013

Unaided visual acuity 0.5 LogMAR
type: Class
subclass of: Abnormal unaided visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073014

Unaided visual acuity 0.6 LogMAR
type: Class
subclass of: Abnormal unaided visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073015

Unaided visual acuity 0.7 LogMAR
type: Class
subclass of: Abnormal unaided visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073016

Unaided visual acuity 0.8 LogMAR
type: Class
subclass of: Abnormal unaided visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073017

Unaided visual acuity 0.9 LogMAR
type: Class
subclass of: Abnormal unaided visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073018

Unaided visual acuity 1.0 LogMAR
type: Class
subclass of: Abnormal unaided visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073019

Unaided visual acuity 1.1 LogMAR
type: Class
subclass of: Abnormal unaided visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073020

Unaided visual acuity 1.2 LogMAR
type: Class
subclass of: Abnormal unaided visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073021

Unaided visual acuity 1.3 LogMAR
type: Class
subclass of: Abnormal unaided visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073022

Unaided visual acuity 2.0 LogMAR
type: Class
subclass of: Abnormal unaided visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073023

Unaided visual acuity 3.0 LogMAR
type: Class
subclass of: Abnormal unaided visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073024

Visual acuity light perception with projection
type: Class
subclass of: Visual acuity test abnormality
imported from: hp.owl
database_cross_reference: UMLS:C4073025

Visual acuity light perception without projection
type: Class
subclass of: Visual acuity test abnormality
imported from: hp.owl
database_cross_reference: UMLS:C4073026

Visual acuity no light perception
type: Class
subclass of: Visual acuity test abnormality
imported from: hp.owl
database_cross_reference: SNOMEDCT_US:63063006
database_cross_reference: UMLS:C0442774

Best corrected visual acuity 0.1 LogMAR
type: Class
subclass of: Abnormal best corrected visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073027

Best corrected visual acuity 0.2 LogMAR
type: Class
subclass of: Abnormal best corrected visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073028

Best corrected visual acuity 0.3 LogMAR
type: Class
subclass of: Abnormal best corrected visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073029

Best corrected visual acuity 0.4 LogMAR
type: Class
subclass of: Abnormal best corrected visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073030

Best corrected visual acuity 0.5 LogMAR
type: Class
subclass of: Abnormal best corrected visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073031

Best corrected visual acuity 0.7 LogMAR
type: Class
subclass of: Abnormal best corrected visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073032

Best corrected visual acuity 0.6 LogMAR
type: Class
subclass of: Abnormal best corrected visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073033

Best corrected visual acuity 0.8 LogMAR
type: Class
subclass of: Abnormal best corrected visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073034

Best corrected visual acuity 0.9 LogMAR
type: Class
subclass of: Abnormal best corrected visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073035

Best corrected visual acuity 1.0 LogMAR
type: Class
subclass of: Abnormal best corrected visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073036

Best corrected visual acuity 1.1 LogMAR
type: Class
subclass of: Abnormal best corrected visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073037

Best corrected visual acuity 1.2 LogMAR
type: Class
subclass of: Abnormal best corrected visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073038

Best corrected visual acuity 1.3 LogMAR
type: Class
subclass of: Abnormal best corrected visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073039

Best corrected visual acuity 2.0 LogMAR
type: Class
subclass of: Abnormal best corrected visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073040

Best corrected visual acuity 3.0 LogMAR
type: Class
subclass of: Abnormal best corrected visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073041

Pinhole visual acuity 0.1 LogMAR
type: Class
subclass of: Abnormal pinhole visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073042

Pinhole visual acuity 0.2 LogMAR
type: Class
subclass of: Abnormal pinhole visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073043

Pinhole visual acuity 0.3 LogMAR
type: Class
subclass of: Abnormal pinhole visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073044

Pinhole visual acuity 0.4 LogMAR
type: Class
subclass of: Abnormal pinhole visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073045

Pinhole visual acuity 0.5 LogMAR
type: Class
subclass of: Abnormal pinhole visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073046

Pinhole visual acuity 0.6 LogMAR
type: Class
subclass of: Abnormal pinhole visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073047

Pinhole visual acuity 0.7 LogMAR
type: Class
subclass of: Abnormal pinhole visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073048

Pinhole visual acuity 0.8 LogMAR
type: Class
subclass of: Abnormal pinhole visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073049

Pinhole visual acuity 0.9 LogMAR
type: Class
subclass of: Abnormal pinhole visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073050

Pinhole visual acuity 1.0 LogMAR
type: Class
subclass of: Abnormal pinhole visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073051

Pinhole visual acuity 1.1 LogMAR
type: Class
subclass of: Abnormal pinhole visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073052

Pinhole visual acuity 1.2 LogMAR
type: Class
subclass of: Abnormal pinhole visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073053

Pinhole visual acuity 1.3 LogMAR
type: Class
subclass of: Abnormal pinhole visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073054

Pinhole visual acuity 2.0 LogMAR
type: Class
subclass of: Abnormal pinhole visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073055

Pinhole visual acuity 3.0 LogMAR
type: Class
subclass of: Abnormal pinhole visual acuity test
imported from: hp.owl
database_cross_reference: UMLS:C4073056

Ecchymosis
type: Class
subclass of: Subcutaneous hemorrhage
textual definition: A purpuric lesion that is larger than 1 cm in diameter.
imported from: hp.owl
date: 2017-08-29T12:32:57Z
created_by: peter
has exact synonym: Ecchymoses

Mildly reduced visual acuity
type: Class
subclass of: Reduced visual acuity
textual definition: Mild reduction of the ability to see defined as visual acuity less than 6/12 (20/40 in US notation; 0.5 in decimal notation) but at least 6/18 (20/63 in US notation; 0.32 in decimal notation).
imported from: hp.owl
date: 2018-09-01T15:45:56Z
created_by: peter
has exact synonym: Mild reduction in visual acuity
has exact synonym: Mild vision loss
has exact synonym: Mild visual loss
comment: A visual acuity of 6/6 signifies that a person can see symbols such as those on a Snellen chart from six meters the same as a person with normal eyesight. A visual acuity of 6/12 signifies that the person can see symbols at 6 meters the same as a person with normal eyesight could at 12 meters.

Very low visual acuity
type: Class
subclass of: Reduced visual acuity
textual definition: A reduction in visual acuity with best corrected visual acuity between 1.40 (20/500) and 1.89 logMAR (up to roughly 20/1590).
imported from: hp.owl
date: 2018-11-18T14:04:38Z
created_by: peter

Ultra-low vision
type: Class
subclass of: Reduced visual acuity
textual definition: Best corrected visual acuity worse than 1.90 logMAR (roughly 20/1590).
imported from: hp.owl
date: 2018-11-18T14:06:19Z
created_by: peter

Ultra-low vision with retained motion projection
type: Class
subclass of: Ultra-low vision
textual definition: Ultra-low vision but with retained ability to identify a moving object (typically hand motion at distance of 30 cm).
imported from: hp.owl
date: 2019-02-10T13:52:59Z
created_by: peter

Ultra-low vision with retained light projection
type: Class
subclass of: Ultra-low vision
textual definition: Ultra-low vision but with retained ability to perceive the difference between light and dark. Also when light is projected in each of the four quadrants of the visual field, the individual is able to correctly identify the origin of the light stimulus.
imported from: hp.owl
date: 2019-02-10T13:53:42Z
created_by: peter

Ultra-low vision with retained light perception
type: Class
subclass of: Ultra-low vision
textual definition: Ultra-low vision but with retained ability to perceive the difference between light and dark.
imported from: hp.owl
date: 2019-02-10T13:54:32Z
created_by: peter

Ultra-low vision with no light perception
type: Class
subclass of: Ultra-low vision
textual definition: Ultra-low vision with complete lack of light and form perception.
imported from: hp.owl
date: 2019-02-10T13:55:07Z
created_by: peter

Blue nevus
type: Class
subclass of: Nevus
imported from: hp.owl
created_by: doelkens
creation_date: 2011-06-09T02:15:28Z
database_cross_reference: MSH:D049328
database_cross_reference: SNOMEDCT_US:40467008
database_cross_reference: UMLS:C0265985
database_cross_reference: UMLS:C4020699
has exact synonym: Mongolian spot
has_obo_namespace: human_phenotype
has_related_synonym: Congenital dermal melanocytosis
id: HP:0100814

melanoma ontology
type: Class

Axillary Lymph Node Dissection without Prior Sentinel Lymph Node Biopsy
type: Class
subclass of: Axillary Lymph Node Dissection
textual definition: A surgical procedure in which the axillary lymph node group is dissected and removed without prior removal and examination of the sentinel lymph node.
imported from: ncit.owl
code: C105784
Semantic_Type: Health Care Activity
Preferred_Name: Axillary Lymph Node Dissection without Prior Sentinel Lymph Node Biopsy
UMLS_CUI: C3831427
has exact synonym: Axillary Lymph Node Dissection without Prior Sentinel Lymph Node Biopsy

BRAF NP_004324.2:p.V600X
type: Class
subclass of: BRAF Protein Variant
textual definition: A change in the valine at position 600 of the serine/threonine-protein kinase B-raf protein to another amino acid.
imported from: ncit.owl
code: C105823
Semantic_Type: Cell or Molecular Dysfunction
Display_Name: BRAF NP_004324.2:p.V600X
Preferred_Name: BRAF NP_004324.2:p.V600X
UMLS_CUI: C3812172
Contributing_Source: CPTAC
Contributing_Source: CTEP
Contributing_Source: CTRP
has exact synonym: BRAF Codon 600 Mutation
has exact synonym: BRAF NP_004324.2:p.V600X
has exact synonym: BRAF NP_004324.2:p.Val600 Mutation
has exact synonym: BRAF NP_004324.2:p.Val600Xxx
has exact synonym: BRAF V600 Mutation
has exact synonym: BRAF V600 Protein Variation
has exact synonym: BRAF V600X
has exact synonym: BRAF p.V600 Mutation
has exact synonym: BRAF p.V600X
has exact synonym: BRAF p.Val600 Mutation
has exact synonym: BRAF p.Val600Xxx
has exact synonym: NP_004324.2:p.V600 Mutation
has exact synonym: NP_004324.2:p.V600X
has exact synonym: NP_004324.2:p.Val600 Mutation
has exact synonym: NP_004324.2:p.Val600Xxx
has exact synonym: Other BRAF V600 mutation
has exact synonym: Serine/Threonine-Protein Kinase B-raf Protein V600 Mutation
has exact synonym: Serine/Threonine-Protein Kinase B-raf Protein V600 Protein Variation
has exact synonym: Serine/Threonine-Protein Kinase B-raf Protein V600X
has exact synonym: Serine/Threonine-Protein Kinase B-raf Protein Val600 Mutation
has exact synonym: Serine/Threonine-Protein Kinase B-raf Protein Val600Xxx
in subset: NCIT C116977
in subset: NCIT C118168
in subset: NCIT C142799
in subset: NCIT C142800
in subset: NCIT C156952
in subset: NCIT C156953
in subset: NCIT C159417

Palliative Radiation Therapy
type: Class
subclass of: Radiation Therapy
subclass of: Therapeutic Procedure
textual definition: Any radiation treatment done with the intent to relieve symptoms and reduce the suffering caused by the cancer, and not with the intent of curing the cancer.
imported from: ncit.owl
code: C116433
Semantic_Type: Therapeutic or Preventive Procedure
Display_Name: Palliative Radiation Therapy
Preferred_Name: Palliative Radiation Therapy
NCI_META_CUI: CL421682
Contributing_Source: CTRP
has exact synonym: Palliative Radiation Therapy
in subset: NCIT C116977
in subset: NCIT C118169

Immunomodulation Therapy
type: Class
subclass of: Immunotherapy
textual definition: Any treatment modality that exercises its effects by inducing, enhancing, or suppressing an immune response.
imported from: ncit.owl
code: C116540
Semantic_Type: Therapeutic or Preventive Procedure
Display_Name: Immunomodulation Therapy
Preferred_Name: Immunomodulation Therapy
UMLS_CUI: C1963758
Contributing_Source: CTRP
has exact synonym: Immunomodulation Therapy
in subset: NCIT C116977
in subset: NCIT C118169

Central Lymph Node Dissection
type: Class
subclass of: Neck Dissection
textual definition: Dissection of the lymph nodes that surround the thyroid gland.
imported from: ncit.owl
code: C118544
Semantic_Type: Therapeutic or Preventive Procedure
Display_Name: Central Lymph Node Dissection
Preferred_Name: Central Lymph Node Dissection
NCI_META_CUI: CL388451
Contributing_Source: CTRP
has exact synonym: Central Lymph Node Dissection
in subset: NCIT C116977
in subset: NCIT C118169

Multiple Agent Systemic Chemotherapy
type: Class
subclass of: Combination Chemotherapy
subclass of: Systemic Chemotherapy
textual definition: Systemic chemotherapy with a multiple agent regimen. All routes of administration are acceptable as long as the regimen is intended for systemic therapy.
imported from: ncit.owl
code: C118618
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Multiple Agent Systemic Chemotherapy
UMLS_CUI: C0854615
ALT_DEFINITION: Systemic chemotherapy with a regimen containing multiple agents.
has exact synonym: Chemotherapy multiple agents systemic
has exact synonym: Multiple Agent Systemic Chemotherapy

Sentinel Lymph Node Biopsy Followed by Axillary Lymph Node Biopsy
type: Class
subclass of: Lymph Node Biopsy
textual definition: A staging procedure consisting of sentinel node biopsy followed by surgical evaluation of the axillary lymph nodes.
imported from: ncit.owl
code: C120282
Semantic_Type: Diagnostic Procedure
Preferred_Name: Sentinel Lymph Node Biopsy Followed by Axillary Lymph Node Biopsy
UMLS_CUI: C3897644
has exact synonym: Sentinel Lymph Node Biopsy Followed by Axillary Lymph Node Biopsy
has exact synonym: Sentinel node biopsy followed by surgical evaluation of axilla

Minimum of 6 Axillary Nodes
type: Class
subclass of: Lymph Node Biopsy
textual definition: Lymph node dissection of at least 6 axillary lymph nodes.
imported from: ncit.owl
code: C120287
Semantic_Type: Diagnostic Procedure
Preferred_Name: Minimum of 6 Axillary Nodes
UMLS_CUI: C3898304
has exact synonym: Minimum of 6 Axillary Nodes
has exact synonym: With a minimum of 6 axillary nodes

Anti-PD1 Monoclonal Antibody
type: Class
subclass of: Monoclonal Antibody
subclass of: Immunotherapeutic Agent
textual definition: A monoclonal antibody directed against programmed cell death protein 1 (PD-1; PD1; CD279).
imported from: ncit.owl
code: C128037
Semantic_Type: Chemical Viewed Structurally
Semantic_Type: Pharmacologic Substance
Preferred_Name: Anti-PD1 Monoclonal Antibody
NCI_META_CUI: CL509685
has exact synonym: Anti-PD-1 Monoclonal Antibody
has exact synonym: Anti-PD1 Monoclonal Antibody

Antineoplastic Biological Agent
type: Class
subclass of: Antineoplastic Agent
subclass of: Biological Agent
textual definition: Any agent that has a biological nature, such as agents containing living organisms, derived from living organisms, or comprised of ex vivo synthesized analogs of substances derived from living organisms, and that exerts antineoplastic activity.
imported from: ncit.owl
code: C129821
Semantic_Type: Pharmacologic Substance
Display_Name: Antineoplastic Biological Agent
Preferred_Name: Antineoplastic Biological Agent
NCI_META_CUI: CL512906
Contributing_Source: CTRP
has exact synonym: Anti-cancer Biological Agent
has exact synonym: Anticancer Biological
has exact synonym: Antineoplastic Biological
has exact synonym: Antineoplastic Biological Agent
has exact synonym: Antineoplastic Biotherapeutic
in subset: NCIT C116977
in subset: NCIT C116978
in subset: NCIT C128784

Antineoplastic Enzyme Inhibitor
type: Class
subclass of: Antineoplastic Agent
subclass of: Enzyme Inhibitor
textual definition: Any agent that specifically inhibits a particular enzyme that is overexpressed and/or mutated in cancer cell pathways. Antineoplastic enzyme inhibitors specifically target tumor cells by targeting enzymes that are not normally expressed or are minimally expressed in normal, healthy tissues.
imported from: ncit.owl
code: C129825
Semantic_Type: Pharmacologic Substance
Preferred_Name: Antineoplastic Enzyme Inhibitor
NCI_META_CUI: CL512907
has exact synonym: Anti-cancer Enzyme Inhibitor
has exact synonym: Antineoplastic Enzyme Inhibitor

Gross Total Resection
type: Class
subclass of: Excision
textual definition: Surgical removal of an entire visible lesion, with no obvious lesion detected on post-operative evaluation; microscopic residual disease may be present.
imported from: ncit.owl
Has_NICHD_Parent: Surgical Procedure
code: C131672
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Gross Total Resection
NCI_META_CUI: CL514299
Contributing_Source: CPTAC
Contributing_Source: GDC
Contributing_Source: NICHD
ALT_DEFINITION: Surgical removal of an entire visible lesion, with no obvious lesion detected on post-operative evaluation; microscopic residual disease may be present.
NICHD_Hierarchy_Term: Gross Total Resection
Maps_To: Gross Total Resection
has exact synonym: Gross Total Resection
in subset: NCIT C132009
in subset: NCIT C156952
in subset: NCIT C156953
in subset: NCIT C157531
in subset: NCIT C157711
in subset: NCIT C90259

Para-Aortic Lymph Node Biopsy
type: Class
subclass of: Excisional Biopsy of Lymph Node
textual definition: A surgical procedure in which a single or multiple para-aortic lymph nodes are removed for microscopic examination.
imported from: ncit.owl
code: C136289
Semantic_Type: Diagnostic Procedure
Preferred_Name: Para-Aortic Lymph Node Biopsy
UMLS_CUI: C0585092
Contributing_Source: NCCN
has exact synonym: Para-Aortic Lymph Node Biopsy
has exact synonym: Para-Aortic Lymph Node Sampling

RAF Family Gene Mutation
type: Class
subclass of: Gene Abnormality
textual definition: A change in the nucleotide sequence in a RAF family gene.
imported from: ncit.owl
Related_To_Genetic_Biomarker: NCIT C18338
Related_To_Genetic_Biomarker: NCIT C18354
Related_To_Genetic_Biomarker: NCIT C18363
code: C136425
Semantic_Type: Cell or Molecular Dysfunction
Display_Name: RAF Family Gene Mutation
Preferred_Name: RAF Family Gene Mutation
NCI_META_CUI: CL523728
Contributing_Source: CTRP
has exact synonym: Mutant RAF
has exact synonym: Mutant RAF Family Gene
has exact synonym: RAF Family Gene Mutation
has exact synonym: RAF Family Mutation
has exact synonym: RAF Mutation
in subset: NCIT C116977
in subset: NCIT C118168
in subset: NCIT C142799
in subset: NCIT C142800

Mediastinal Lymph Node Biopsy
type: Class
subclass of: Lymph Node Biopsy
textual definition: Removal or sampling of lymph nodes in the mediastinum.
imported from: ncit.owl
code: C137934
Semantic_Type: Diagnostic Procedure
Preferred_Name: Mediastinal Lymph Node Biopsy
UMLS_CUI: C0398435
Contributing_Source: NCCN
has exact synonym: Mediastinal Lymph Node Biopsy

Supraclavicular Lymph Node Biopsy
type: Class
subclass of: Lymph Node Biopsy
textual definition: Removal or sampling of lymph nodes in the supraclavicular area.
imported from: ncit.owl
code: C137935
Semantic_Type: Diagnostic Procedure
Preferred_Name: Supraclavicular Lymph Node Biopsy
UMLS_CUI: C1300768
Contributing_Source: NCCN
has exact synonym: Supraclavicular Lymph Node Biopsy

Mediastinal Lymph Node Dissection
type: Class
subclass of: Regional Lymph Node Dissection
textual definition: A surgical procedure in which all or most all of the lymph nodes are removed from the mediastinum.
imported from: ncit.owl
code: C139566
Semantic_Type: Health Care Activity
Display_Name: Mediastinal Lymph Node Dissection
Preferred_Name: Mediastinal Lymph Node Dissection
NCI_META_CUI: CL526891
Contributing_Source: CTRP
has exact synonym: Mediastinal Lymph Node Dissection
in subset: NCIT C116977
in subset: NCIT C118169

Mediastinal Lymph Node Sampling
type: Class
subclass of: Excisional Biopsy of Lymph Node
textual definition: A surgical procedure in which a single or multiple mediastinal lymph nodes are removed for microscopic examination.
imported from: ncit.owl
code: C139751
Semantic_Type: Diagnostic Procedure
Preferred_Name: Mediastinal Lymph Node Sampling
UMLS_CUI: C0398421
Contributing_Source: NCCN
has exact synonym: Mediastinal Lymph Node Sampling

Protein Kinase Inhibitor
type: Class
subclass of: Enzyme Inhibitor
textual definition: Any substance that inhibits protein kinase, an enzyme that catalyzes the addition of a phosphate group to a protein and is active in many diverse signaling pathways.
imported from: ncit.owl
code: C1404
Semantic_Type: Chemical Viewed Functionally
Display_Name: Protein Kinase Inhibitor
Preferred_Name: Protein Kinase Inhibitor
UMLS_CUI: C1449702
Contributing_Source: CTRP
Legacy_Concept_Name: Protein_Kinase_Inhibitor
CHEBI_ID: CHEBI:37699
has exact synonym: Protein Kinase Inhibitor
in subset: NCIT C116977
in subset: NCIT C116978

Salvage Surgery
type: Class
subclass of: Surgical Procedure by Type
subclass of: Therapeutic Procedure
textual definition: Surgical treatment undertaken after failure of initial surgery or failure of other modalities.
imported from: ncit.owl
code: C146855
Semantic_Type: Therapeutic or Preventive Procedure
Display_Name: Salvage Surgery
Preferred_Name: Salvage Surgery
NCI_META_CUI: CL544837
Contributing_Source: CTRP
has exact synonym: Rescue Surgery
has exact synonym: Salvage Resection
has exact synonym: Salvage Surgery
has exact synonym: Salvage Surgical Resection
has exact synonym: Surgical Salvage
in subset: NCIT C116977
in subset: NCIT C118169

Percutaneous Hepatic Perfusion
type: Class
subclass of: Isolated Chemotherapeutic Hepatic Perfusion
textual definition: A minimally invasive procedure in which high dose chemotherapy is delivered directly to the liver via a catheter placed in the hepatic artery, and the effluent blood returning through the hepatic veins is filtered via an extracorporeal system before being returned through a sheath in the internal jugular vein.
imported from: ncit.owl
code: C148433
Semantic_Type: Therapeutic or Preventive Procedure
Display_Name: Percutaneous Hepatic Perfusion
Preferred_Name: Percutaneous Hepatic Perfusion
NCI_META_CUI: CL550987
Contributing_Source: CTRP
has exact synonym: Percutaneous Hepatic Perfusion
in subset: NCIT C116977
in subset: NCIT C118169

Bilateral Modified Radical Neck Dissection
type: Class
subclass of: Neck Dissection
textual definition: A surgical procedure in which all the bilateral cervical lymph node groups of the neck are removed but the internal jugular veins, sternocleidomastoid muscles, and/or spinal accessory nerves are preserved.
imported from: ncit.owl
code: C148527
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Bilateral Modified Radical Neck Dissection
UMLS_CUI: C0193866
Contributing_Source: CPTAC
has exact synonym: Bilateral Modified Radical Neck Dissection
has exact synonym: Functional (Limited) Neck Dissection
has exact synonym: Functional Bilateral Neck Dissection
in subset: NCIT C156952
in subset: NCIT C156953
in subset: NCIT C159419

Biopsy
type: Class
subclass of: Diagnostic Procedure
textual definition: The removal of tissue specimens or fluid from the living body for microscopic examination, performed to establish a diagnosis.
imported from: ncit.owl
code: C15189
Semantic_Type: Diagnostic Procedure
Display_Name: Biopsy
Preferred_Name: Biopsy
UMLS_CUI: C0005558
Contributing_Source: CDISC
Contributing_Source: CTRP
Contributing_Source: GDC
ALT_DEFINITION: The removal of cells or tissues for examination by a pathologist. The pathologist may study the tissue under a microscope or perform other tests on the cells or tissue. There are many different types of biopsy procedures. The most common types include: (1) incisional biopsy, in which only a sample of tissue is removed; (2) excisional biopsy, in which an entire lump or suspicious area is removed; and (3) needle biopsy, in which a sample of tissue or fluid is removed with a needle.
ALT_DEFINITION: The removal of tissue specimens or fluid from the living body for microscopic examination, performed to establish a diagnosis.
Legacy_Concept_Name: Biopsy
Maps_To: Biopsy
has exact synonym: BIOPSY
has exact synonym: Biopsy
has exact synonym: Bx
has exact synonym: biopsy
in subset: NCIT C116977
in subset: NCIT C118169
in subset: NCIT C132314
in subset: NCIT C157711
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C85492

Needle Biopsy
type: Class
subclass of: Biopsy
textual definition: The removal of a tissue sample using a needle, for microscopic examination.
imported from: ncit.owl
code: C15190
Semantic_Type: Diagnostic Procedure
Display_Name: Needle Biopsy
Preferred_Name: Needle Biopsy
UMLS_CUI: C0005560
Contributing_Source: CTRP
Contributing_Source: GDC
ALT_DEFINITION: The removal of tissue or fluid with a needle for examination under a microscope. When a wide needle is used, the procedure is called a core biopsy. When a thin needle is used, the procedure is called a fine-needle aspiration biopsy.
Legacy_Concept_Name: Needle_Biopsy
Maps_To: Needle Biopsy
has exact synonym: Aspiration Biopsy
has exact synonym: Needle Biopsy
has exact synonym: Puncture Biopsy
has exact synonym: needle biopsy
in subset: NCIT C116977
in subset: NCIT C118169
in subset: NCIT C157711

Diagnosis
type: Class
subclass of: Diagnostic Procedure
textual definition: The investigation, analysis and recognition of the presence and nature of disease, condition, or injury from expressed signs and symptoms; also, the scientific determination of any kind; the concise results of such an investigation.
imported from: ncit.owl
Has_NICHD_Parent: NCIT C3367
code: C15220
Semantic_Type: Diagnostic Procedure
Preferred_Name: Diagnosis
UMLS_CUI: C0011900
Contributing_Source: CDISC
Contributing_Source: GDC
Contributing_Source: NICHD
ALT_DEFINITION: The investigation, analysis and recognition of the presence and nature of disease, condition, or injury from expressed signs and symptoms; also, the scientific determination of any kind; the concise results or summary of such an investigation. (NCI)
ALT_DEFINITION: The process of identifying a disease, such as cancer, from its signs and symptoms.
Legacy_Concept_Name: Diagnosis
NICHD_Hierarchy_Term: Diagnosis
Maps_To: Diagnosis
has exact synonym: DIAGNOSIS
has exact synonym: Diagnosed
has exact synonym: Diagnosis
has exact synonym: Diagnostic
has exact synonym: Dx
has exact synonym: diagnosis
in subset: NCIT C124301
in subset: NCIT C132298
in subset: NCIT C147067
in subset: NCIT C157711
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77526
in subset: NCIT C89506
in subset: NCIT C90012
in subset: NCIT C90259

Excision
type: Class
subclass of: Surgical Procedure by Method
textual definition: The act of cutting out; the surgical removal of part or all of a structure or organ.
imported from: ncit.owl
code: C15232
Semantic_Type: Health Care Activity
Display_Name: Excision
Preferred_Name: Excision
UMLS_CUI: C0728940
Contributing_Source: CDISC
Contributing_Source: CTRP
Contributing_Source: GDC
ALT_DEFINITION: Removal by surgery.
ALT_DEFINITION: The act of cutting out; the surgical removal of part or all of a structure or organ. (NCI)
Legacy_Concept_Name: Excision
Maps_To: Surgical Resection
has exact synonym: Abscission
has exact synonym: EXCISION
has exact synonym: Excision
has exact synonym: Excisional
has exact synonym: Extirpation
has exact synonym: Removal
has exact synonym: Resection
has exact synonym: Surgical Removal
has exact synonym: Surgical Resection
has exact synonym: excision
has exact synonym: resection
in subset: NCIT C101858
in subset: NCIT C116977
in subset: NCIT C118169
in subset: NCIT C157711
in subset: NCIT C61410
in subset: NCIT C66830

Immunotherapy
type: Class
subclass of: Therapeutic Procedure
textual definition: Therapy designed to induce changes in a patient's immune status in order to treat disease.
imported from: ncit.owl
code: C15262
Semantic_Type: Therapeutic or Preventive Procedure
Display_Name: Immunotherapy
Preferred_Name: Immunotherapy
UMLS_CUI: C0021083
Contributing_Source: CDISC
Contributing_Source: CPTAC
Contributing_Source: CTRP
ALT_DEFINITION: A therapy designed to induce changes in a patient's immune status.
ALT_DEFINITION: Treatment to boost or restore the ability of the immune system to fight cancer, infections, and other diseases. Also used to lessen certain side effects that may be caused by some cancer treatments. Agents used in immunotherapy include monoclonal antibodies, growth factors, and vaccines. These agents may also have a direct antitumor effect.
Legacy_Concept_Name: Immunotherapy
Maps_To: Immunotherapy (Including Vaccines)
DesignNote: The concept encompasses various treatment modalities including active and passive immunization, treatment with immunopotentiators, immunosuppressants and nonspecific systemic immunostimulators and adjuvants, desensitization to any allergens, bone marrow transplantation, thymus implantation.
has exact synonym: IMMUNOTHERAPY
has exact synonym: Immunological
has exact synonym: Immunological Therapy
has exact synonym: Immunologically Directed Therapy
has exact synonym: Immunotherapy
has exact synonym: immunotherapy
in subset: NCIT C101858
in subset: NCIT C116977
in subset: NCIT C118169
in subset: NCIT C156952
in subset: NCIT C156953
in subset: NCIT C156954
in subset: NCIT C156955
in subset: NCIT C157711
in subset: NCIT C158037
in subset: NCIT C158520
in subset: NCIT C159328
in subset: NCIT C61410
in subset: NCIT C66830

Lymphadenectomy
type: Class
subclass of: Surgical Procedure by Site or System
subclass of: Surgical Procedure by Method
textual definition: Surgical removal of lymph nodes, usually done to assess the spread of cancer.
imported from: ncit.owl
code: C15275
Semantic_Type: Health Care Activity
Display_Name: Lymphadenectomy
Preferred_Name: Lymphadenectomy
UMLS_CUI: C0024203
Contributing_Source: CTRP
ALT_DEFINITION: A surgical procedure in which the lymph nodes are removed and a sample of tissue is checked under a microscope for signs of cancer. For a regional lymphadenectomy, some of the lymph nodes in the tumor area are removed; for a radical lymphadenectomy, most or all of the lymph nodes in the tumor area are removed.
Legacy_Concept_Name: Lymphadenectomy
has exact synonym: Lymph Node Dissection
has exact synonym: Lymphadenectomy
has exact synonym: excision of the lymph node
has exact synonym: lymph node dissection
has exact synonym: lymph node excision
has exact synonym: lymphadenectomy
in subset: NCIT C116977
in subset: NCIT C118169
in subset: NCIT C157711

Chemotherapeutic Perfusion
type: Class
subclass of: Regional Chemotherapy
textual definition: The process of flooding fluid through the artery to saturate the surrounding tissue. In regional perfusion, a specific area of the body (usually an arm or a leg) is targeted and high doses of anticancer drugs are flooded through the artery to reach the surrounding tissue and kill as many cancer cells as possible. Such a procedure is performed in cases where the cancer is not thought to have spread past a localized area.
imported from: ncit.owl
code: C15295
Semantic_Type: Therapeutic or Preventive Procedure
Display_Name: Chemotherapeutic Perfusion
Preferred_Name: Chemotherapeutic Perfusion
UMLS_CUI: C0031001
Contributing_Source: CTRP
ALT_DEFINITION: Bathing an organ or tissue with a fluid. In regional perfusion, a specific area of the body (usually an arm or a leg) receives high doses of anticancer drugs through a blood vessel. Such a procedure is performed to treat cancer that has not spread.
Legacy_Concept_Name: Perfusion
has exact synonym: Chemotherapeutic Perfusion
has exact synonym: Perfusion
has exact synonym: perfusion
in subset: NCIT C116977
in subset: NCIT C118169

Isolated Chemotherapeutic Perfusion
type: Class
subclass of: Chemotherapeutic Perfusion
textual definition: The delivery of chemotherapy to a specific tissue area that is excluded from the general circulation during the period of infusion, which allows for a high concentration of the drug in the tumour area as well as sparing of the rest of the body from the side effects of the drug.
imported from: ncit.owl
code: C15296
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Isolated Chemotherapeutic Perfusion
UMLS_CUI: C0031006
Legacy_Concept_Name: Isolated_Perfusion
has exact synonym: Isolated Chemotherapeutic Perfusion
has exact synonym: perfusion, isolated

Radiation Therapy
type: Class
subclass of: Therapeutic Procedure
textual definition: Treatment of a disease by means of exposure of the target or the whole body to radiation. Radiation therapy is often used as part of curative therapy and occasionally as a component of palliative treatment for cancer. Other uses include total body irradiation prior to transplantation.
imported from: ncit.owl
code: C15313
Semantic_Type: Therapeutic or Preventive Procedure
Display_Name: Radiation Therapy
Preferred_Name: Radiation Therapy
UMLS_CUI: C1522449
Contributing_Source: CDISC
Contributing_Source: CPTAC
Contributing_Source: CTRP
Contributing_Source: GDC
ALT_DEFINITION: The use of high-energy radiation from x-rays, gamma rays, neutrons, protons, and other sources to kill cancer cells and shrink tumors. Radiation may come from a machine outside the body (external-beam radiation therapy), or it may come from radioactive material placed in the body near cancer cells (internal radiation therapy). Systemic radiation therapy uses a radioactive substance, such as a radiolabeled monoclonal antibody, that travels in the blood to tissues throughout the body.
ALT_DEFINITION: Treatment of a disease by means of exposure of the target or the whole body to radiation.
Legacy_Concept_Name: Radiation_Therapy
Maps_To: Radiation Therapy, NOS
has exact synonym: Cancer Radiotherapy
has exact synonym: Irradiate
has exact synonym: Irradiated
has exact synonym: Irradiation
has exact synonym: RADIATION
has exact synonym: RADIOTHERAPY
has exact synonym: RT
has exact synonym: Radiation
has exact synonym: Radiation Therapy
has exact synonym: Radiation Therapy, NOS
has exact synonym: Radiotherapeutics
has exact synonym: Radiotherapy
has exact synonym: Therapy, Radiation
has exact synonym: irradiated
has exact synonym: irradiation
has exact synonym: radiation therapy
has exact synonym: radiotherapy
in subset: NCIT C101858
in subset: NCIT C116977
in subset: NCIT C118169
in subset: NCIT C156952
in subset: NCIT C156953
in subset: NCIT C156954
in subset: NCIT C156955
in subset: NCIT C157711
in subset: NCIT C158037
in subset: NCIT C158520
in subset: NCIT C159328
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C99078

Surgical Procedure
type: Class
subclass of: Intervention or Procedure
textual definition: A diagnostic or treatment procedure performed by manual and/or instrumental means, often involving an incision and the removal or replacement of a diseased organ or tissue; of or relating to or involving or used in surgery or requiring or amenable to treatment by surgery.
imported from: ncit.owl
Has_NICHD_Parent: Intervention or Procedure
code: C15329
Semantic_Type: Health Care Activity
Display_Name: Surgical Procedure
Preferred_Name: Surgical Procedure
UMLS_CUI: C0543467
Contributing_Source: CPTAC
Contributing_Source: CTRP
Contributing_Source: GDC
Contributing_Source: NICHD
ALT_DEFINITION: A procedure to remove or repair a part of the body or to find out whether disease is present. An operation.
Legacy_Concept_Name: Surgical_Procedure
NICHD_Hierarchy_Term: Surgical Procedure
Maps_To: Surgery
Maps_To: Surgically Treated
has exact synonym: Operation
has exact synonym: Surgery
has exact synonym: Surgical
has exact synonym: Surgical Interventions
has exact synonym: Surgical Procedure
has exact synonym: Surgical Procedures
has exact synonym: Surgically
has exact synonym: Type of Surgery
has exact synonym: surgery
in subset: NCIT C116977
in subset: NCIT C118169
in subset: NCIT C156952
in subset: NCIT C156953
in subset: NCIT C156954
in subset: NCIT C157524
in subset: NCIT C157526
in subset: NCIT C157527
in subset: NCIT C157528
in subset: NCIT C157529
in subset: NCIT C157530
in subset: NCIT C157532
in subset: NCIT C157533
in subset: NCIT C157534
in subset: NCIT C157711
in subset: NCIT C159412
in subset: NCIT C90259

Radioimmunotherapy
type: Class
subclass of: Immunotherapy
subclass of: Radiation Therapy
subclass of: Cancer Immunotherapy
textual definition: Treatment with a radioactive substance that is linked to an antibody so that it will attach to a tumor when injected into the body.
imported from: ncit.owl
code: C15355
Semantic_Type: Therapeutic or Preventive Procedure
Display_Name: Radioimmunotherapy
Preferred_Name: Radioimmunotherapy
UMLS_CUI: C0085101
Contributing_Source: CTRP
ALT_DEFINITION: The use of radiolabeled monoclonal antibodies to treat diseases, including cancer. The radiolabeled monoclonal antibody locates and binds to substances in the body, including cancer cells. Radiation given off by the radioisotope may help kill the cancer cells.
Legacy_Concept_Name: Radioimmunotherapy
has exact synonym: Immunoradiotherapy
has exact synonym: Immunotherapy, Cancer, Radioisotope
has exact synonym: Radioimmunotherapy
has exact synonym: radioimmunotherapeutics
has exact synonym: radioimmunotherapy
in subset: NCIT C116977
in subset: NCIT C118169

Excisional Biopsy
type: Class
subclass of: Biopsy
subclass of: Excision
subclass of: Diagnostic Surgical Procedure
textual definition: A surgical procedure in which an entire lesion is removed for microscopic examination.
imported from: ncit.owl
code: C15385
Semantic_Type: Diagnostic Procedure
Preferred_Name: Excisional Biopsy
UMLS_CUI: C0184921
Contributing_Source: CPTAC
Contributing_Source: GDC
ALT_DEFINITION: A surgical procedure in which an entire lump or suspicious area is removed for diagnosis. The tissue is then examined under a microscope.
Legacy_Concept_Name: Excisional_Biopsy
Maps_To: Excisional Biopsy
has exact synonym: Excisional Biopsy
has exact synonym: Excisional biopsy
has exact synonym: excisional biopsy
has exact synonym: surgical biopsy
in subset: NCIT C156952
in subset: NCIT C157711
in subset: NCIT C159328
in subset: NCIT C159330
in subset: NCIT C159331
in subset: NCIT C159332

Incisional Biopsy
type: Class
subclass of: Biopsy
textual definition: A surgical procedure in which part of a lesion is removed for microscopic examination.
imported from: ncit.owl
code: C15386
Semantic_Type: Diagnostic Procedure
Preferred_Name: Incisional Biopsy
UMLS_CUI: C0184922
Contributing_Source: CPTAC
Contributing_Source: GDC
ALT_DEFINITION: A procedure in which a surgical incision (cut) is made through the skin to expose and remove tissues. The biopsy tissue is examined under a microscope by a pathologist. An open biopsy may be done in the doctor's office or in the hospital, and may use local anesthesia or general anesthesia. A lumpectomy to remove a breast tumor is a type of open biopsy.
Legacy_Concept_Name: Incisional_Biopsy
Maps_To: Incisional Biopsy
has exact synonym: Incisional Biopsy
has exact synonym: Open Biopsy
has exact synonym: incisional biopsy
has exact synonym: open biopsy
in subset: NCIT C156952
in subset: NCIT C156953
in subset: NCIT C157531
in subset: NCIT C157711
in subset: NCIT C159328
in subset: NCIT C159330
in subset: NCIT C159331
in subset: NCIT C159332

Isolated Chemotherapeutic Limb Perfusion
type: Class
subclass of: Isolated Chemotherapeutic Perfusion
imported from: ncit.owl
code: C15393
Semantic_Type: Therapeutic or Preventive Procedure
Display_Name: Isolated Chemotherapeutic Limb Perfusion
Preferred_Name: Isolated Chemotherapeutic Limb Perfusion
UMLS_CUI: C0396670
Contributing_Source: CTRP
Contributing_Source: GDC
ALT_DEFINITION: A procedure used to deliver anticancer drugs directly to an arm or leg but not to the rest of the body. The flow of blood to and from the limb is temporarily stopped with a tourniquet (a tight band around the limb). Catheters (small, flexible tubes) attached to a pump are put into an artery and a vein in the limb so that blood can be circulated through the pump into the limb. Anticancer drugs are injected into the catheters. Wrapping the limb in a heated blanket or warming the drugs or blood may help the drugs work better.
Legacy_Concept_Name: Limb_Perfusion
Maps_To: Isolated Limb Perfusion (ILP)
has exact synonym: Isolated Chemotherapeutic Limb Perfusion
has exact synonym: Isolated Limb Perfusion (ILP)
has exact synonym: Limb Perfusion
has exact synonym: isolated limb infusion
has exact synonym: isolated limb perfusion
has exact synonym: limb perfusion
in subset: NCIT C116977
in subset: NCIT C118169
in subset: NCIT C157711

Cancer Immunotherapy
type: Class
subclass of: Immunotherapy
subclass of: Chemotherapy
subclass of: Pharmacotherapy
textual definition: Use of techniques, biologically active substances, and procedures to enhance or restore the ability of the host immune system to fight cancer. Also used to lessen adverse effects that may be caused by some cancer treatments.
imported from: ncit.owl
code: C15438
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Cancer Immunotherapy
UMLS_CUI: C0278348
Legacy_Concept_Name: Cancer_Immunotherapy
has exact synonym: Cancer Immunotherapy
has exact synonym: Immuno-Chemotherapy
has exact synonym: Immunotherapy, Cancer, General
has exact synonym: immunotherapy for cancer

BRAF Inhibitor
type: Class
subclass of: Protein Kinase Inhibitor
textual definition: Any agent that inhibits the serine/threonine-protein kinase BRAF(B-RAF).
imported from: ncit.owl
code: C155322
Semantic_Type: Pharmacologic Substance
Display_Name: BRAF Inhibitor
Preferred_Name: BRAF Inhibitor
NCI_META_CUI: CL556869
Contributing_Source: CTRP
has exact synonym: B-RAF Inhibitor
has exact synonym: BRAF Inhibitor
in subset: NCIT C116977
in subset: NCIT C116978
in subset: NCIT C157711
in subset: NCIT C157712

Intraperitoneal Chemotherapy
type: Class
subclass of: Regional Chemotherapy
textual definition: The administration of pharmaceutical agents directly into the abdominal or peritoneal cavity. This technique is widely utilized for the chemotherapeutic treatment of advanced ovarian cancer.
imported from: ncit.owl
code: C15581
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Intraperitoneal Chemotherapy
UMLS_CUI: C0281548
ALT_DEFINITION: Treatment in which anticancer drugs are put directly into the abdominal cavity through a thin tube.
Legacy_Concept_Name: Intraperitoneal_Therapy
has exact synonym: Intraperitoneal Chemotherapy
has exact synonym: Intraperitoneal Therapy
has exact synonym: intraperitoneal chemotherapy

Clinical Diagnosis
type: Class
subclass of: Diagnosis
textual definition: A diagnosis made from a study of the signs and symptoms of a disease.
imported from: ncit.owl
code: C15607
Semantic_Type: Idea or Concept
Preferred_Name: Clinical Diagnosis
UMLS_CUI: C0332140
Legacy_Concept_Name: Clinical_Diagnosis
has exact synonym: Clinical Diagnosis

Chemotherapy
type: Class
subclass of: Therapeutic Procedure
textual definition: The use of synthetic or naturally-occurring chemicals for the treatment of diseases.
imported from: ncit.owl
code: C15632
Semantic_Type: Therapeutic or Preventive Procedure
Display_Name: Chemotherapy
Preferred_Name: Chemotherapy
UMLS_CUI: C0392920
Contributing_Source: CDISC
Contributing_Source: CPTAC
Contributing_Source: CTRP
Contributing_Source: GDC
ALT_DEFINITION: Non-systemic chemotherapy treatment (e.g., intra-peritoneal, intra-cavitary, intra-thecal), or chemotherapy not described by Chemotherapy Single Agent Systemic or Multi-Agent Systemic.
ALT_DEFINITION: The use of synthetic or naturally-occurring chemicals for the treatment of diseases.
ALT_DEFINITION: Treatment with anticancer drugs.
Legacy_Concept_Name: Chemotherapy
Maps_To: Chemotherapy
DesignNote: Although this term is used to describe any therapy involving the use of chemical-based agents, it is particularly used to refer to the use of chemical-based agents to treat cancer. Antineoplastic chemotherapy works by arresting or killing the growth and spread of cancer cells. Chemotherapy may also include agents that enhance immune function or alter hormonal activity.
has exact synonym: CHEMOTHERAPY
has exact synonym: Chemo
has exact synonym: Chemotherapy
has exact synonym: Chemotherapy (NOS)
has exact synonym: Chemotherapy, Cancer, General
has exact synonym: chemotherapy
in subset: NCIT C101858
in subset: NCIT C116977
in subset: NCIT C118169
in subset: NCIT C156952
in subset: NCIT C156953
in subset: NCIT C156954
in subset: NCIT C156955
in subset: NCIT C157711
in subset: NCIT C157712
in subset: NCIT C158037
in subset: NCIT C158520
in subset: NCIT C159328
in subset: NCIT C61410
in subset: NCIT C66830

Neck Dissection
type: Class
subclass of: Regional Lymph Node Dissection
subclass of: Surgical Procedure by Site or System
imported from: ncit.owl
code: C15643
Semantic_Type: Therapeutic or Preventive Procedure
Display_Name: Neck Dissection
Preferred_Name: Neck Dissection
UMLS_CUI: C0398395
Contributing_Source: CTRP
ALT_DEFINITION: Surgery to remove lymph nodes and other tissues in the neck.
Legacy_Concept_Name: Neck_Dissection
has exact synonym: Neck Dissection
has exact synonym: neck dissection
in subset: NCIT C116977
in subset: NCIT C118169

Sentinel Lymph Node Biopsy
type: Class
subclass of: Lymph Node Biopsy
textual definition: Surgical removal and examination of the sentinel node, the lymph node which is first in receiving the lymphatic drainage of a specified anatomic location and is most likely to be affected by the lymphatic spread of cancer.
imported from: ncit.owl
code: C15667
Semantic_Type: Diagnostic Procedure
Display_Name: Sentinel Lymph Node Biopsy
Preferred_Name: Sentinel Lymph Node Biopsy
UMLS_CUI: C0796693
Contributing_Source: CTRP
ALT_DEFINITION: Removal and examination of the sentinel node(s) (the first lymph node(s) to which cancer cells are likely to spread from a primary tumor). To identify the sentinel lymph node(s), the surgeon injects a radioactive substance, blue dye, or both near the tumor. The surgeon then uses a probe to find the sentinel lymph node(s) containing the radioactive substance or looks for the lymph node(s) stained with dye. The surgeon then removes the sentinel node(s) to check for the presence of cancer cells.
Legacy_Concept_Name: Sentinel_Lymph_Node_Biopsy
has exact synonym: SLNB
has exact synonym: SNB
has exact synonym: Sentinel Lymph Node Biopsy
has exact synonym: Sentinel Node Biopsy
has exact synonym: Sentinel node biopsy alone
has exact synonym: sentinel lymph node biopsy
in subset: NCIT C116977
in subset: NCIT C118169

Axillary Lymph Node Dissection
type: Class
subclass of: Regional Lymph Node Dissection
textual definition: Surgical removal of the lymph nodes located in the cavity beneath the junction of the arm and the thorax, or axilla (armpit). This procedure is commonly performed as a component of cancer staging.
imported from: ncit.owl
code: C15677
Semantic_Type: Health Care Activity
Display_Name: Axillary Lymph Node Dissection
Preferred_Name: Axillary Lymph Node Dissection
UMLS_CUI: C0193867
Contributing_Source: CTRP
ALT_DEFINITION: Surgery to remove lymph nodes found in the armpit region.
Legacy_Concept_Name: Axillary_Lymph_Node_Dissection
has exact synonym: ALND
has exact synonym: Axillary Dissection
has exact synonym: Axillary Lymph Node Dissection
has exact synonym: Axillary Lymphadenectomy
has exact synonym: Axillary Node Dissection
has exact synonym: Excision Axillary Lymph Nodes
has exact synonym: axillary dissection
has exact synonym: axillary lymph node dissection
in subset: NCIT C116977
in subset: NCIT C118169

Epidural Chemotherapy
type: Class
subclass of: Intrathecal Chemotherapy
imported from: ncit.owl
code: C15683
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Epidural Chemotherapy
UMLS_CUI: C1526986
Legacy_Concept_Name: Epidural
has exact synonym: Epidural Chemotherapy

Chemotherapeutic Hyperthermic Perfusion
type: Class
subclass of: Chemotherapeutic Perfusion
imported from: ncit.owl
code: C15684
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Chemotherapeutic Hyperthermic Perfusion
UMLS_CUI: C1512558
ALT_DEFINITION: A procedure in which a warmed solution containing anticancer drugs is used to bathe, or is passed through the blood vessels of, the tissue or organ containing the tumor.
Legacy_Concept_Name: Hyperthermic_Perfusion
has exact synonym: Chemotherapeutic Hyperthermic Perfusion
has exact synonym: hyperthermic perfusion

Isolated Chemotherapeutic Hepatic Perfusion
type: Class
subclass of: Isolated Chemotherapeutic Perfusion
imported from: ncit.owl
code: C15686
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Isolated Chemotherapeutic Hepatic Perfusion
UMLS_CUI: C1517606
ALT_DEFINITION: A procedure in which a catheter is placed into the artery that provides blood to the liver; another catheter is placed into the vein that takes blood away from the liver. This temporarily separates the liver's blood supply from blood circulating throughout the rest of the body and allows high doses of anticancer drugs to be directed to the liver only.
Legacy_Concept_Name: Isolated_Hepatic_Perfusion
has exact synonym: Isolated Chemotherapeutic Hepatic Perfusion
has exact synonym: isolated hepatic perfusion

Local Therapy
type: Class
subclass of: Therapeutic Procedure
textual definition: Any therapeutic procedure that targets, or is restricted to, a specific anatomical location.
imported from: ncit.owl
code: C15687
Semantic_Type: Therapeutic or Preventive Procedure
Display_Name: Local Therapy
Preferred_Name: Local Therapy
UMLS_CUI: C1517925
Contributing_Source: CTRP
ALT_DEFINITION: Treatment that affects cells in the tumor and the area close to it.
Legacy_Concept_Name: Local_Therapy
has exact synonym: Local Therapy
has exact synonym: Localized Therapy
has exact synonym: local therapy
in subset: NCIT C116977
in subset: NCIT C118169

Chemotherapeutic Peritoneal Perfusion
type: Class
subclass of: Chemotherapeutic Perfusion
subclass of: Intraperitoneal Chemotherapy
imported from: ncit.owl
code: C15730
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Chemotherapeutic Peritoneal Perfusion
UMLS_CUI: C1519011
ALT_DEFINITION: A method of delivering fluids and drugs directly to tumors in the peritoneal cavity.
Legacy_Concept_Name: Peritoneal_Perfusion
has exact synonym: Chemotherapeutic Peritoneal Perfusion
has exact synonym: peritoneal perfusion

Continuous Chemotherapeutic Hyperthermic Peritoneal Perfusion
type: Class
subclass of: Chemotherapeutic Hyperthermic Perfusion
subclass of: Chemotherapeutic Peritoneal Perfusion
imported from: ncit.owl
code: C15732
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Continuous Chemotherapeutic Hyperthermic Peritoneal Perfusion
UMLS_CUI: C1511496
ALT_DEFINITION: A procedure that bathes the abdominal cavity in fluid that contains anticancer drugs. This fluid is warmer than body temperature. This procedure appears to kill cancer cells without harming normal cells.
Legacy_Concept_Name: Continuous_Hyperthermic_Peritoneal_Perfusion
has exact synonym: CHPP
has exact synonym: Continuous Chemotherapeutic Hyperthermic Peritoneal Perfusion
has exact synonym: continuous hyperthermic peritoneal perfusion

Intrathecal Chemotherapy
type: Class
subclass of: Local Therapy
subclass of: Regional Chemotherapy
imported from: ncit.owl
code: C15750
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Intrathecal Chemotherapy
UMLS_CUI: C1517560
ALT_DEFINITION: Treatment in which anticancer drugs are injected into the fluid-filled space between the thin layers of tissue that cover the brain and spinal cord.
Legacy_Concept_Name: Intrathecal_Chemotherapy
has exact synonym: Intrathecal Chemotherapy
has exact synonym: intrathecal chemotherapy

External Beam Radiation Therapy
type: Class
subclass of: Radiation Therapy
textual definition: Radiation therapy in which high-energy beams are delivered to the tumor from outside of the body.
imported from: ncit.owl
code: C15751
Semantic_Type: Therapeutic or Preventive Procedure
Display_Name: External Beam Radiation Therapy
Preferred_Name: External Beam Radiation Therapy
UMLS_CUI: C0419095
Contributing_Source: CDISC
Contributing_Source: CTRP
Contributing_Source: GDC
ALT_DEFINITION: A type of radiation therapy in which high-energy beams are delivered to the tumor from outside of the body.
ALT_DEFINITION: A type of radiation therapy that uses a machine to aim high-energy rays at the cancer from outside of the body.
Legacy_Concept_Name: External_Beam_Radiation
Maps_To: External Beam Radiation
Maps_To: Radiation, External Beam
has exact synonym: Definitive Radiation Therapy
has exact synonym: EBRT
has exact synonym: EXTERNAL BEAM RADIATION THERAPY
has exact synonym: External Beam RT
has exact synonym: External Beam Radiation
has exact synonym: External Beam Radiation Therapy
has exact synonym: External Beam Radiotherapy
has exact synonym: External Radiation Therapy
has exact synonym: Radiation, External Beam
has exact synonym: external radiation
has exact synonym: external-beam radiation
in subset: NCIT C101858
in subset: NCIT C116977
in subset: NCIT C118169
in subset: NCIT C157711
in subset: NCIT C61410
in subset: NCIT C66830

Single Agent Systemic Chemotherapy
type: Class
subclass of: Systemic Chemotherapy
textual definition: Systemic chemotherapy with a single agent regimen. All routes of administration are acceptable as long as the agent is intended for systemic therapy.
imported from: ncit.owl
code: C15756
Semantic_Type: Clinical Attribute
Preferred_Name: Single Agent Systemic Chemotherapy
UMLS_CUI: C0854619
ALT_DEFINITION: Systemic chemotherapy with a single agent regimen.
Legacy_Concept_Name: Single_Agent_Systemic_Chemotherapy
has exact synonym: Chemotherapy Single Agent Systemic
has exact synonym: Chemotherapy single agent systemic
has exact synonym: Single Agent Systemic Chemotherapy

Cancer Detection
type: Class
subclass of: Detection
textual definition: The act of discovery of a malignant neoplasm, and after treatment, the discovery of minimal residual disease.
imported from: ncit.owl
code: C15776
Semantic_Type: Diagnostic Procedure
Preferred_Name: Cancer Detection
UMLS_CUI: C1516193
Legacy_Concept_Name: Cancer_Detection
has exact synonym: Cancer Detection

Detection of Minimal Residual Disease
type: Class
subclass of: Detection
textual definition: The discovery of a tumor or cancer after primary, potentially curative therapy.
imported from: ncit.owl
code: C15795
Semantic_Type: Diagnostic Procedure
Preferred_Name: Detection of Minimal Residual Disease
UMLS_CUI: C1511791
Legacy_Concept_Name: Detection_of_Minimal_Residual_Disease
has exact synonym: Detection of Minimal Residual Disease

Topical Medications for Melanoma
type: Class
subclass of: Topical Chemotherapy
textual definition: Medications that are applied to the skin for melanoma.
imported from: ncit.owl
code: C158014
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Topical Medications for Melanoma
NCI_META_CUI: CL937558
Contributing_Source: CPTAC
has exact synonym: Topical Medications for Melanoma
in subset: NCIT C156952
in subset: NCIT C158037
in subset: NCIT C158520

Topical Medications for Non-Melanoma
type: Class
subclass of: Topical Chemotherapy
textual definition: Medications that are applied to the skin for non-melanoma lesions.
imported from: ncit.owl
code: C158015
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Topical Medications for Non-Melanoma
NCI_META_CUI: CL937559
Contributing_Source: CPTAC
has exact synonym: Topical Medications for Non-Melanoma
in subset: NCIT C156952
in subset: NCIT C158037
in subset: NCIT C158520

Low Dose Radiation Therapy
type: Class
subclass of: Radiation Therapy
textual definition: Radiotherapy using radioactive particles that deposit a low amount of energy by radiation per unit length of travel.
imported from: ncit.owl
code: C15811
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Low Dose Radiation Therapy
UMLS_CUI: C1518010
Legacy_Concept_Name: Low_Dose_Radiation
has exact synonym: Low Dose Radiation
has exact synonym: Low Dose Radiation Therapy

Prevention, Early Detection of Premalignant Lesions
type: Class
subclass of: Early Detection
textual definition: A procedure that includes screening, diet and behavioral adjustments to prevent and/or detect the transformation of normal cells into cancerous lesions.
imported from: ncit.owl
code: C15842
Semantic_Type: Diagnostic Procedure
Preferred_Name: Prevention, Early Detection of Premalignant Lesions
UMLS_CUI: C1514407
Legacy_Concept_Name: Prevention_Early_Detection_of_Premalignant_Lesions
has exact synonym: Prevention, Early Detection of Premalignant Lesions

BRAF Exon 15 Mutation
type: Class
subclass of: BRAF Gene Mutation
textual definition: A molecular genetic abnormality indicating the presence of a mutation in exon 15 of the BRAF gene.
imported from: ncit.owl
code: C158854
Semantic_Type: Cell or Molecular Dysfunction
Preferred_Name: BRAF Exon 15 Mutation
Contributing_Source: CPTAC
has exact synonym: B-RAF Exon 15 Mutation
has exact synonym: B-RAF1 Exon 15 Mutation
has exact synonym: BRAF Exon 15 Gene Mutation
has exact synonym: BRAF Exon 15 Mutation
has exact synonym: BRAF1 Exon 15 Mutation
has exact synonym: Exon 15
has exact synonym: v-raf Murine Sarcoma Viral Oncogene Homolog B1 Exon 15 Mutation
in subset: NCIT C156952
in subset: NCIT C156953
in subset: NCIT C159414

Regional Chemotherapy
type: Class
subclass of: Chemotherapy
subclass of: Local Therapy
subclass of: Pharmacotherapy
textual definition: A form of chemotherapy in which the drug(s) are placed into a specific location, including a body cavity or individual organ, for the purpose of killing cancer cells whilst minimizing systemic toxicity.
imported from: ncit.owl
code: C15912
Semantic_Type: Therapeutic or Preventive Procedure
Display_Name: Regional Chemotherapy
Preferred_Name: Regional Chemotherapy
UMLS_CUI: C1514818
Contributing_Source: CTRP
ALT_DEFINITION: Treatment with anticancer drugs directed to a specific area of the body.
Legacy_Concept_Name: Regional_Chemotherapy
has exact synonym: Regional Chemotherapy
has exact synonym: regional chemotherapy
in subset: NCIT C116977
in subset: NCIT C118169

Topical Chemotherapy
type: Class
subclass of: Regional Chemotherapy
imported from: ncit.owl
code: C15914
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Topical Chemotherapy
UMLS_CUI: C1519552
ALT_DEFINITION: Treatment with anticancer drugs in a lotion or cream applied to the skin.
Legacy_Concept_Name: Topical_Chemotherapy
has exact synonym: Topical Chemotherapy
has exact synonym: topical chemotherapy

Ilioinguinal Lymphadenectomy
type: Class
subclass of: Diagnostic Lymphadenectomy
textual definition: Surgical removal of the inguinal, iliac, and obturator lymph nodes.
imported from: ncit.owl
code: C159444
Semantic_Type: Diagnostic Procedure
Preferred_Name: Ilioinguinal Lymphadenectomy
has exact synonym: Ilioinguinal Lymphadenectomy

Chemical Cancer Immunotherapy
type: Class
subclass of: Immunotherapy
subclass of: Cancer Immunotherapy
textual definition: Chemical Cancer Immunotherapy is the use of chemical substances to alter the interaction between the host's immune defenses and cancer cells to boost, direct, or restore the body's ability to fight cancer.
imported from: ncit.owl
code: C15975
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Chemical Cancer Immunotherapy
UMLS_CUI: C1516447
Legacy_Concept_Name: Chemical_Cancer_Immunotherapy
has exact synonym: Chemical Cancer Immunotherapy
has exact synonym: Immunotherapy, Cancer, Chemical
has exact synonym: chemical immunotherapy for cancer

Pharmacotherapy
type: Class
subclass of: Therapeutic Procedure
textual definition: Treatment of disease through the use of drugs.
imported from: ncit.owl
Has_NICHD_Parent: Intervention or Procedure
code: C15986
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Pharmacotherapy
UMLS_CUI: C0013216
Contributing_Source: CPTAC
Contributing_Source: GDC
Contributing_Source: NICHD
ALT_DEFINITION: Treatment with any substance, other than food, that is used to prevent, diagnose, treat, or relieve symptoms of a disease or abnormal condition.
Legacy_Concept_Name: Pharmacological_Treatment
NICHD_Hierarchy_Term: Drug Therapy
Maps_To: Pharmaceutical Therapy, NOS
has exact synonym: Drug Therapy
has exact synonym: Pharmaceutical Therapy
has exact synonym: Pharmaceutical Therapy, NOS
has exact synonym: Pharmacological Treatment
has exact synonym: Pharmacological Treatments
has exact synonym: Pharmacotherapy
has exact synonym: Treatment With Medication
has exact synonym: drug therapy
in subset: NCIT C156952
in subset: NCIT C157711
in subset: NCIT C158037
in subset: NCIT C158520
in subset: NCIT C90259

Non-Invasive Cancer Detection
type: Class
subclass of: Cancer Detection
textual definition: Methods of detection which do not require penetration of the body or body openings.
imported from: ncit.owl
code: C16107
Semantic_Type: Diagnostic Procedure
Preferred_Name: Non-Invasive Cancer Detection
UMLS_CUI: C1518360
Legacy_Concept_Name: Non-Invasive_Cancer_Detection
has exact synonym: Non-Invasive Cancer Detection
has exact synonym: Non-Invasive Detection

Robot-assisted Salvage Pelvic Lymph Node Dissection
type: Class
subclass of: Salvage Surgery
subclass of: Pelvic Lymphadenectomy
textual definition: A surgical technique that uses a specially designed robotic system to aid removal of pelvic lymph nodes after failure of initial surgery or other treatment modalities.
imported from: ncit.owl
code: C161314
Semantic_Type: Therapeutic or Preventive Procedure
Display_Name: Robot-assisted Salvage Pelvic Lymph Node Dissection
Preferred_Name: Robot-assisted Salvage Pelvic Lymph Node Dissection
Contributing_Source: CTRP
has exact synonym: RoboInOwlt-assisted Salvage Pelvic Lymph Node Dissection
in subset: NCIT C116977
in subset: NCIT C118169

Focal Cutaneous Irradiation
type: Class
subclass of: Radiation Therapy
textual definition: A procedure involving irradiation to a specific, limited area of the skin.
imported from: ncit.owl
code: C161507
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Focal Cutaneous Irradiation
Contributing_Source: CDISC
ALT_DEFINITION: A procedure involving irradiation of a specific, limited area of the skin.
has exact synonym: CUTANEOUS IRRADIATION
has exact synonym: Focal Cutaneous Irradiation
in subset: NCIT C160927
in subset: NCIT C61410
in subset: NCIT C77526

Surgical Procedure by Type
type: Class
subclass of: Surgical Procedure
textual definition: A categorization of surgical procedures by type or purpose.
imported from: ncit.owl
code: C161601
Semantic_Type: Health Care Activity
Preferred_Name: Surgical Procedure by Type
has exact synonym: Surgical Procedure by Type

Early Detection
type: Class
subclass of: Detection
textual definition: Use of a device, marker, or other means for the purpose of detecting the presence of a tumor early in its development.
imported from: ncit.owl
code: C16209
Semantic_Type: Diagnostic Procedure
Preferred_Name: Early Detection
NCI_META_CUI: CL448355
Legacy_Concept_Name: Early_Detection
has exact synonym: Early Detection

Detection
type: Class
subclass of: Diagnostic Procedure
textual definition: The activity of perceiving, discerning, discovering or identifying.
imported from: ncit.owl
code: C16210
Semantic_Type: Diagnostic Procedure
Preferred_Name: Detection
UMLS_CUI: C1511790
Legacy_Concept_Name: Detection
has exact synonym: Detected
has exact synonym: Detection

Cancer Diagnosis
type: Class
subclass of: Diagnosis
textual definition: General term for detecting and classifying cancer in patients.
imported from: ncit.owl
code: C16213
Semantic_Type: Diagnostic Procedure
Preferred_Name: Cancer Diagnosis
UMLS_CUI: C0920688
Legacy_Concept_Name: Cancer_Diagnosis
has exact synonym: Cancer Diagnosis

Bilateral Pelvic Lymph Node Dissection
type: Class
subclass of: Pelvic Lymphadenectomy
textual definition: Removal of one or more pelvic lymph nodes from both sides of the body.
imported from: ncit.owl
code: C166163
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Bilateral Pelvic Lymph Node Dissection
has exact synonym: Bilateral Pelvic Lymph Node Dissection

Palpation
type: Class
subclass of: Physical Examination
textual definition: A method of feeling with the hands during a physical examination. The health care provider touches and feels the patient's body to examine the size, consistency, texture, location and tenderness of an organ or body part.
imported from: ncit.owl
code: C16950
Semantic_Type: Diagnostic Procedure
Preferred_Name: Palpation
UMLS_CUI: C0030247
Contributing_Source: CDISC
ALT_DEFINITION: A method of feeling with the hands during a physical examination. The health care provider touches and feels the patient's body to examine the size, consistency, texture, location and tenderness of an organ or body part.
ALT_DEFINITION: Examination by pressing on the surface of the body to feel the organs or tissues underneath.
Legacy_Concept_Name: Palpation
has exact synonym: PALPATION
has exact synonym: Palpation
has exact synonym: palpation
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C85492

Diagnostic Procedure
type: Class
subclass of: Intervention or Procedure
textual definition: Any procedure or test to diagnose a disease or disorder.
imported from: ncit.owl
Has_NICHD_Parent: Intervention or Procedure
code: C18020
Semantic_Type: Diagnostic Procedure
Display_Name: Diagnostic Procedure
Preferred_Name: Diagnostic Procedure
UMLS_CUI: C0430022
Contributing_Source: CTRP
Contributing_Source: NICHD
ALT_DEFINITION: A specific test or series of steps done to help diagnose a disease or condition. Mammograms and colonscopies are examples of diagnostic procedures.
Legacy_Concept_Name: Diagnostic_Procedure
NICHD_Hierarchy_Term: Diagnostic Procedure
Maps_To: Other diagnostic procedures on breast
Maps_To: Other diagnostic procedures on rectum, rectosigmoid and perirectal tissue
has exact synonym: Diagnostic Method
has exact synonym: Diagnostic Procedure
has exact synonym: Diagnostic Technique
has exact synonym: Diagnostic Test
has exact synonym: diagnostic procedure
has exact synonym: diagnostic technique
in subset: NCIT C116977
in subset: NCIT C118169
in subset: NCIT C90259

Pharmacologic Substance
type: Class
subclass of: melanoma ontology
textual definition: Any natural, endogenously-derived, synthetic or semi-synthetic compound with pharmacologic activity. A pharmacologic substance has one or more specific mechanism of action(s) through which it exerts one or more effect(s) on the human or animal body. They can be used to potentially prevent, diagnose, treat or relieve symptoms of a disease. Formulation specific agents and some combination agents are also classified as pharmacologic substances.
imported from: ncit.owl
Has_NICHD_Parent: NCIT C45306
code: C1909
Semantic_Type: Pharmacologic Substance
Preferred_Name: Pharmacologic Substance
UMLS_CUI: C1254351
Contributing_Source: BRIDG
Contributing_Source: CDISC
Contributing_Source: CDISC-GLOSS
Contributing_Source: FDA
Contributing_Source: NICHD
ALT_DEFINITION: An active natural, synthetic or semi-synthetic ingredient including endogenous body substance that is intended to furnish pharmacological activity or other direct effect in the diagnosis, cure, mitigation, treatment, or prevention of disease or to affect the structure or any function of the human body, but does not include intermediates used in the synthesis of such ingredient (21 CFR 314.3(b)).
ALT_DEFINITION: An article other than food intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease; or intended to affect the structure or any function of the body. EXAMPLE(S): aspirin
ALT_DEFINITION: Any substance, other than food, that is used to prevent, diagnose, treat or relieve symptoms of a disease or abnormal condition. Also refers to a substance that alters mood or body function, or that can be habit-forming or addictive, especially a narcotic.
ALT_DEFINITION: Article other than food intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease; or intended to affect the structure or any function of the body. not a device or a component, part, or accessory of a device. [from FDA Glossary of Terms, CDER] See also medicinal product, active substance.
Legacy_Concept_Name: Pharmacologic_Substance
CHEBI_ID: CHEBI:52217
NICHD_Hierarchy_Term: Pharmacologic Substance
DesignNote: This category represents ingredients, not drug products.
has exact synonym: Agent
has exact synonym: DRUG
has exact synonym: Drug
has exact synonym: Drug Substance
has exact synonym: Pharmaceutical Agent
has exact synonym: Pharmaceuticals
has exact synonym: Pharmacologic Agent
has exact synonym: Pharmacologic Substance
has exact synonym: Pharmacological Substance
has exact synonym: Product
has exact synonym: drug
in subset: NCIT C133805
in subset: NCIT C133855
in subset: NCIT C159501
in subset: NCIT C159503
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C67497
in subset: NCIT C90259
in subset: NCIT C96388
in subset: NCIT C99078

Combination Chemotherapy
type: Class
subclass of: Chemotherapy
subclass of: Pharmacotherapy
imported from: ncit.owl
code: C191
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Combination Chemotherapy
UMLS_CUI: C1521750
ALT_DEFINITION: Treatment using more than one anticancer drug.
Legacy_Concept_Name: Combination_Chemotherapy
has exact synonym: Chemotherapy, Combination
has exact synonym: Combination Chemotherapy
has exact synonym: Combination Drug Therapy
has exact synonym: Drug Therapy, Combination
has exact synonym: combination chemotherapy

Monoclonal Antibody
type: Class
subclass of: Biological Agent
subclass of: Immunotherapeutic Agent
textual definition: An antibody produced by a clone or genetically homogenous fast-growing cells i.e., hybridoma. Hybridoma cells are cloned to establish cell lines producing a specific antibody that is chemically and immunologically homogeneous. They are widely used in cancer detection, diagnosis, and treatment.
imported from: ncit.owl
code: C20401
Semantic_Type: Amino Acid, Peptide, or Protein
Display_Name: Monoclonal Antibody
Preferred_Name: Monoclonal Antibody
UMLS_CUI: C0003250
Contributing_Source: CTRP
ALT_DEFINITION: A type of protein made in the laboratory that can bind to substances in the body, including tumor cells. There are many kinds of monoclonal antibodies. Each monoclonal antibody is made to find one substance. Monoclonal antibodies are being used to treat some types of cancer and are being studied in the treatment of other types. They can be used alone or to carry drugs, toxins, or radioactive materials directly to a tumor.
Legacy_Concept_Name: Monoclonal_Antibody
has exact synonym: MAb
has exact synonym: MoAB
has exact synonym: Monoclonal Antibodies
has exact synonym: Monoclonal Antibody
has exact synonym: Monoclonal Antibody Therapy
has exact synonym: monoclonal antibody
in subset: NCIT C116977
in subset: NCIT C116978

Breast Cancer Early Detection
type: Class
subclass of: Early Detection
textual definition: Use of a device, marker, or other means for the purpose of detecting the presence of a breast tumor early in its development.
imported from: ncit.owl
code: C20698
Semantic_Type: Diagnostic Procedure
Preferred_Name: Breast Cancer Early Detection
NCI_META_CUI: CL502478
Legacy_Concept_Name: Breast_Cancer_Early_Detection
has exact synonym: Breast Cancer Early Detection
has exact synonym: Early Detection of Breast Cancer

Physical Examination
type: Class
subclass of: Diagnostic Procedure
textual definition: A systemic evaluation of the body and its functions using visual inspection, palpation, percussion and auscultation. The purpose is to determine the presence or absence of physical signs of disease or abnormality for an individual's health assessment.
imported from: ncit.owl
Has_NICHD_Parent: NCIT C25214
code: C20989
Semantic_Type: Diagnostic Procedure
Display_Name: Physical Examination
Preferred_Name: Physical Examination
UMLS_CUI: C0031809
Contributing_Source: CDISC
Contributing_Source: CTRP
Contributing_Source: GDC
Contributing_Source: NICHD
ALT_DEFINITION: A systemic evaluation of the body and its functions using visual inspection, palpation, percussion and auscultation.
ALT_DEFINITION: An exam of the body to check for general signs of disease.
Legacy_Concept_Name: Physical_Examination
NICHD_Hierarchy_Term: Physical Examination
Maps_To: Physical Exam
has exact synonym: Assessment
has exact synonym: PHYSICAL EXAM
has exact synonym: PHYSICAL EXAMINATION
has exact synonym: Physical
has exact synonym: Physical Assessment
has exact synonym: Physical Exam
has exact synonym: Physical Examination
has exact synonym: assessment
has exact synonym: physical examination
in subset: NCIT C116977
in subset: NCIT C118169
in subset: NCIT C157711
in subset: NCIT C158118
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C77526
in subset: NCIT C85492
in subset: NCIT C89506
in subset: NCIT C89963
in subset: NCIT C90259

Intervention or Procedure
type: Class
subclass of: melanoma ontology
textual definition: An activity that produces an effect, or that is intended to alter the course of a disease in a patient or population. This is a general term that encompasses the medical, social, behavioral, and environmental acts that can have preventive, therapeutic, or palliative effects.
imported from: ncit.owl
Has_NICHD_Parent: NCIT C90259
code: C25218
Semantic_Type: Health Care Activity
Preferred_Name: Intervention or Procedure
UMLS_CUI: C0184661
Contributing_Source: BRIDG
Contributing_Source: CDISC-GLOSS
Contributing_Source: NICHD
ALT_DEFINITION: In medicine, a treatment or action taken to prevent or treat disease, or improve health in other ways.
ALT_DEFINITION: The drug, device, therapy, or process under investigation in a clinical study that is believed to have an effect on outcomes of interest in a study (e.g., health-related quality of life, efficacy, safety, pharmacoeconomics). See also test articles, devices, drug product, medicinal product, combination product, general observation class, finding, event.
Legacy_Concept_Name: Procedure
NICHD_Hierarchy_Term: Intervention or Procedure
has exact synonym: Intervention
has exact synonym: Intervention Strategies
has exact synonym: Intervention or Procedure
has exact synonym: Interventional
has exact synonym: Procedure
has exact synonym: intervention
has exact synonym: interventionDescription
in subset: NCIT C159501
in subset: NCIT C159502
in subset: NCIT C61410
in subset: NCIT C67497
in subset: NCIT C90259
in subset: NCIT C99147

Antineoplastic Agent
type: Class
subclass of: Pharmacologic Substance
textual definition: A substance that inhibits the maturation, growth or spread of tumor cells.
imported from: ncit.owl
code: C274
Semantic_Type: Chemical Viewed Functionally
Preferred_Name: Antineoplastic Agent
UMLS_CUI: C0003392
ALT_DEFINITION: A drug used to treat cancer.
Legacy_Concept_Name: Antineoplastic_Agent
CHEBI_ID: CHEBI:35610
has exact synonym: Anti-Cancer Agents
has exact synonym: Anti-Tumor Agents
has exact synonym: Anti-Tumor Drugs
has exact synonym: Antineoplastic Agent
has exact synonym: Antineoplastic Drugs
has exact synonym: Antineoplastics
has exact synonym: Antiproliferative Agents
has exact synonym: Antiproliferative Drugs
has exact synonym: Cancer Drug
has exact synonym: Chemotherapeutic Agents, Neoplastic Disease
has exact synonym: Tumor-Specific Treatment Agents
has exact synonym: antineoplastic
has exact synonym: chemotherapeutic agent

Biological Agent
type: Class
subclass of: Pharmacologic Substance
textual definition: Biotechnology-derived pharmaceutical agents made from living organisms or their products. Includes recombinant proteins, monoclonal antibodies, and nucleic acids.
imported from: ncit.owl
Has_NICHD_Parent: Pharmacologic Substance
code: C307
Semantic_Type: Classification
Preferred_Name: Biological Agent
UMLS_CUI: C0005522
Contributing_Source: BRIDG
Contributing_Source: CDISC
Contributing_Source: NICHD
ALT_DEFINITION: A class of pharmaceutical agents made from living organisms or their products that includes recombinant proteins, antibodies, and nucleic acids.
ALT_DEFINITION: A substance made from living organisms or things they produce, for example: virus, therapeutic serum, toxin, antitoxin, vaccine, blood, blood component or derivative, allergenic product, or analogous product.
ALT_DEFINITION: A substance made from living organisms or things they produce. EXAMPLE(S): virus, therapeutic serum, toxin, antitoxin, vaccine, blood, blood component or derivative, allergenic product, analogous product
ALT_DEFINITION: A substance that is made from a living organism or its products and is used in the prevention, diagnosis, or treatment of cancer and other diseases. Biological agents include antibodies, interleukins, and vaccines.
Legacy_Concept_Name: Biological_Agent
NICHD_Hierarchy_Term: Biologic
has exact synonym: BIOLOGIC
has exact synonym: Biologic
has exact synonym: Biological Agent
has exact synonym: Biological Drug
has exact synonym: Biological Products
has exact synonym: Biologicals
has exact synonym: Biologics
has exact synonym: Biopharmaceuticals
has exact synonym: Immunologic, Immunochemical
has exact synonym: Immunologics
has exact synonym: biologic agent
has exact synonym: biological agent
has exact synonym: biological drug
in subset: NCIT C118468
in subset: NCIT C159501
in subset: NCIT C159503
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C90259
in subset: NCIT C99078

Immunotherapeutic Agent
type: Class
subclass of: Pharmacologic Substance
textual definition: Any substance that induces, enhances, restores or suppresses the host's immune system, or an agent that utilizes or is derived from a component of the immune system.
imported from: ncit.owl
code: C308
Semantic_Type: Chemical Viewed Functionally
Display_Name: Immunotherapeutic Agent
Preferred_Name: Immunotherapeutic Agent
UMLS_CUI: C0005525
Contributing_Source: CTRP
Legacy_Concept_Name: Biological_Response_Modifier
CHEBI_ID: CHEBI:50846
has exact synonym: BRM
has exact synonym: Biological Response Modifier
has exact synonym: Biomodulators
has exact synonym: Immune Mediators
has exact synonym: Immune Modulators
has exact synonym: Immune Regulators
has exact synonym: Immunomodulating Agent
has exact synonym: Immunomodulators
has exact synonym: Immunomodulatory Agent
has exact synonym: Immunopotentiators
has exact synonym: Immunotherapeutic Agent
has exact synonym: Immunotherapy
has exact synonym: Immunotherapy Agent
in subset: NCIT C116977
in subset: NCIT C116978

Gene Abnormality
type: Class
subclass of: Molecular Genetic Variation
textual definition: A variation in or modification of the nucleic acid sequence of a gene that can alter its expression and may result in either a congenital disorder or the clinical presentation of a disease.
imported from: ncit.owl
code: C36327
Semantic_Type: Cell or Molecular Dysfunction
Preferred_Name: Gene Abnormality
UMLS_CUI: C1517478
Legacy_Concept_Name: Gene_Abnormality
has exact synonym: Gene Abnormality

Molecular Genetic Variation
type: Class
subclass of: Molecular Sequence Variation
textual definition: Any alteration in the inherited nucleic acid sequence of the genotype of an organism.
imported from: ncit.owl
code: C36391
Semantic_Type: Cell or Molecular Dysfunction
Preferred_Name: Molecular Genetic Variation
UMLS_CUI: C0262496
Legacy_Concept_Name: Molecular_Genetic_Abnormality
has exact synonym: Anomaly
has exact synonym: DNA Sequence Variation
has exact synonym: Genetic Abnormality
has exact synonym: Genetic Alteration
has exact synonym: Genetic Anomaly
has exact synonym: Molecular Abnormality
has exact synonym: Molecular Anomaly
has exact synonym: Molecular Genetic Abnormality
has exact synonym: Molecular Genetic Anomaly
has exact synonym: Molecular Genetic Variation

Molecular Abnormality
type: Class
subclass of: melanoma ontology
textual definition: A molecular or cytogenic abnormality which occurs in either human disease states or disease models.
imported from: ncit.owl
code: C3910
Semantic_Type: Cell or Molecular Dysfunction
Preferred_Name: Molecular Abnormality
NCI_META_CUI: CL448235
Legacy_Concept_Name: Molecular_Abnormality
has exact synonym: Chromosomal, Gene, or Protein Abnormality
has exact synonym: Cytogenetic or Molecular Genetic Abnormality
has exact synonym: Genetic Abnormality
has exact synonym: Molecular Abnormality
has exact synonym: Molecular Alteration

BRAF Gene Mutation
type: Class
subclass of: RAF Family Gene Mutation
subclass of: Gene Mutant
textual definition: A change in the nucleotide sequence of the BRAF gene.
imported from: ncit.owl
code: C40430
Semantic_Type: Cell or Molecular Dysfunction
Display_Name: BRAF Gene Mutation
Preferred_Name: BRAF Gene Mutation
UMLS_CUI: C1511021
Contributing_Source: CPTAC
Contributing_Source: CTRP
Legacy_Concept_Name: BRAF_Gene_Mutation
has exact synonym: B-RAF Gene Mutation
has exact synonym: B-RAF1 Gene Mutation
has exact synonym: BRAF Gene Mutation
has exact synonym: BRAF Mutation
has exact synonym: BRAF1 Gene Mutation
has exact synonym: v-raf Murine Sarcoma Viral Oncogene Homolog B1 Gene Mutation
in subset: NCIT C116977
in subset: NCIT C142799
in subset: NCIT C142800
in subset: NCIT C156952
in subset: NCIT C156953
in subset: NCIT C157533
in subset: NCIT C159414
in subset: NCIT C159415

Checkup
type: Class
subclass of: Physical Examination
textual definition: Checkup is a general examination or inspection, especially one carried out by a doctor or dentist.
imported from: ncit.owl
code: C41383
Semantic_Type: Health Care Activity
Preferred_Name: Checkup
UMLS_CUI: C0598836
Legacy_Concept_Name: Checkup
has exact synonym: Check-up
has exact synonym: Checkup

Enzyme Inhibitor
type: Class
subclass of: Pharmacologic Substance
textual definition: A pharmacological agent that inhibits the catalytic activity of an enzyme.
imported from: ncit.owl
code: C471
Semantic_Type: Chemical Viewed Functionally
Preferred_Name: Enzyme Inhibitor
UMLS_CUI: C0014432
Legacy_Concept_Name: Enzyme_Inhibitor
CHEBI_ID: CHEBI:23924
has exact synonym: Enzyme Antagonist
has exact synonym: Enzyme Inhibitor
has exact synonym: Enzyme Inhibitor Agent
has exact synonym: Enzyme Inhibitor Drug

Sentinel Lymph Node Biopsy with Axillary Lymph Node Dissection
type: Class
subclass of: Axillary Lymph Node Dissection
textual definition: A surgical procedure in which the sentinel node is removed followed by dissection and removal of the axillary node group.
imported from: ncit.owl
code: C47854
Semantic_Type: Health Care Activity
Preferred_Name: Sentinel Lymph Node Biopsy with Axillary Lymph Node Dissection
UMLS_CUI: C1710051
Legacy_Concept_Name: Sentinel_Lymph_Node_Biopsy_with_Axillary_Lymph_Node_Dissection
has exact synonym: Axillary Lymph Node Dissection with Prior Sentinel Lymph Node Biopsy
has exact synonym: Sentinel Lymph Node Biopsy with Axillary Lymph Node Dissection

Retroperitoneal Lymph Node Dissection
type: Class
subclass of: Regional Lymph Node Dissection
textual definition: The surgical removal of retroperitoneal lymph nodes from the abdominal cavity. The surgery is a therapeutic treatment for testicular cancer, performed after (orchiectomy) or testicular removal. The surgery is recommended for men who are at an increased risk of metastasis, or who decline other treatment options such as radiation or chemotherapy.
imported from: ncit.owl
code: C48184
Semantic_Type: Therapeutic or Preventive Procedure
Display_Name: Retroperitoneal Lymph Node Dissection
Preferred_Name: Retroperitoneal Lymph Node Dissection
UMLS_CUI: C1112682
Contributing_Source: CTRP
Legacy_Concept_Name: Retroperitoneal_Lymph_Node_Dissection
has exact synonym: RPLND
has exact synonym: Retroperitoneal Lymph Node Dissection
in subset: NCIT C116977
in subset: NCIT C118169

Regional Lymph Node Dissection
type: Class
subclass of: Lymphadenectomy
textual definition: Surgical removal of the lymph nodes located in a particular anatomic region. This procedure is commonly performed as a component of cancer staging.
imported from: ncit.owl
code: C48935
Semantic_Type: Health Care Activity
Display_Name: Regional Lymph Node Dissection
Preferred_Name: Regional Lymph Node Dissection
UMLS_CUI: C1709883
Contributing_Source: CTRP
ALT_DEFINITION: A surgical procedure to remove some of the lymph nodes that drain lymph from the area around a tumor. The lymph nodes are then examined under a microscope to see if cancer cells have spread to them.
Legacy_Concept_Name: Regional_Lymph_Node_Dissection
has exact synonym: Regional Lymph Node Dissection
has exact synonym: regional lymph node dissection
in subset: NCIT C116977
in subset: NCIT C118169

Radical Lymph Node Dissection
type: Class
subclass of: Lymphadenectomy
textual definition: The surgical removal of all or part of the lymph nodes that drain lymph from the area around a tumor.
imported from: ncit.owl
code: C48936
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Radical Lymph Node Dissection
UMLS_CUI: C0193854
ALT_DEFINITION: A surgical procedure to remove most or all of the lymph nodes that drain lymph from the area around a tumor. The lymph nodes are then examined under a microscope to see if cancer cells have spread to them.
Legacy_Concept_Name: Radical_Lymph_Node_Dissection
has exact synonym: Radical Lymph Node Dissection
has exact synonym: radical lymph node dissection

Surgical Procedure by Site or System
type: Class
subclass of: Surgical Procedure
imported from: ncit.owl
code: C49163
Semantic_Type: Classification
Preferred_Name: Surgical Procedure by Site or System
UMLS_CUI: C1710259
Concept_Status: Header_Concept
Legacy_Concept_Name: Surgical_Procedure_by_Site_or_System
has exact synonym: Surgical Procedure by Site or System

Surgical Procedure by Method
type: Class
subclass of: Surgical Procedure
textual definition: A categorization of surgical procedures based on surgical techniques.
imported from: ncit.owl
code: C49165
Semantic_Type: Classification
Preferred_Name: Surgical Procedure by Method
UMLS_CUI: C1710258
Concept_Status: Header_Concept
Legacy_Concept_Name: Surgical_Procedure_by_Method
has exact synonym: Surgical Procedure by Method

Therapeutic Procedure
type: Class
subclass of: Intervention or Procedure
textual definition: An action or administration of therapeutic agents to produce an effect that is intended to alter or stop a pathologic process.
imported from: ncit.owl
Has_NICHD_Parent: Intervention or Procedure
code: C49236
Semantic_Type: Therapeutic or Preventive Procedure
Display_Name: Therapeutic Procedure
Preferred_Name: Therapeutic Procedure
UMLS_CUI: C0087111
Contributing_Source: CDISC-GLOSS
Contributing_Source: CTRP
Contributing_Source: NICHD
ALT_DEFINITION: See intervention.
ALT_DEFINITION: Treatment.
Legacy_Concept_Name: Therapeutic_Procedure
NICHD_Hierarchy_Term: Therapeutic Procedure
has exact synonym: TREAT
has exact synonym: TX
has exact synonym: Therapeutic Interventions
has exact synonym: Therapeutic Method
has exact synonym: Therapeutic Procedure
has exact synonym: Therapeutic Technique
has exact synonym: Therapy
has exact synonym: Treatment
has exact synonym: therapeutic intervention
has exact synonym: therapy
in subset: NCIT C103331
in subset: NCIT C116977
in subset: NCIT C118169
in subset: NCIT C157711
in subset: NCIT C61410
in subset: NCIT C67497
in subset: NCIT C89506
in subset: NCIT C90259

Biopsy of Conjunctiva
type: Class
subclass of: Biopsy
textual definition: Removal of conjunctival tissue for microscopic examination.
imported from: ncit.owl
code: C51486
Semantic_Type: Diagnostic Procedure
Preferred_Name: Biopsy of Conjunctiva
UMLS_CUI: C0197128
Legacy_Concept_Name: Biopsy_of_Conjunctiva
has exact synonym: Biopsy of Conjunctiva
has exact synonym: Conjunctival Biopsy

Biopsy of Pharyngeal Tonsil
type: Class
subclass of: Biopsy
textual definition: Removal of tissue from the pharyngeal tonsil for microscopic examination.
imported from: ncit.owl
code: C51487
Semantic_Type: Diagnostic Procedure
Preferred_Name: Biopsy of Pharyngeal Tonsil
UMLS_CUI: C0193950
Legacy_Concept_Name: Biopsy_of_Pharyngeal_Tonsil
has exact synonym: Biopsy of Adenoids
has exact synonym: Biopsy of Pharyngeal Tonsil

Inguinal Lymphadenectomy
type: Class
subclass of: Regional Lymph Node Dissection
textual definition: Surgical removal of one or more inguinal lymph nodes.
imported from: ncit.owl
code: C51619
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Inguinal Lymphadenectomy
UMLS_CUI: C0193884
Legacy_Concept_Name: Inguinal_Lymphadenectomy
has exact synonym: Inguinal Lymphadenectomy

Block Dissection of Inguinal Lymph Nodes
type: Class
subclass of: Inguinal Lymphadenectomy
textual definition: Surgical removal of multiple adjacent, frequently adherent, inguinal lymph nodes.
imported from: ncit.owl
code: C51620
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Block Dissection of Inguinal Lymph Nodes
UMLS_CUI: C0398406
Legacy_Concept_Name: Block_Dissection_of_Inguinal_Lymph_Nodes
has exact synonym: Block Dissection of Inguinal Lymph Nodes

Excisional Biopsy of Breast
type: Class
subclass of: Biopsy
subclass of: Excisional Biopsy
textual definition: Removal of tissue from the breast for microscopic examination, involving surgical excision of a portion of the breast.
imported from: ncit.owl
code: C51633
Semantic_Type: Diagnostic Procedure
Preferred_Name: Excisional Biopsy of Breast
UMLS_CUI: C0405348
Legacy_Concept_Name: Excisional_Biopsy_of_Breast
has exact synonym: Excisional Biopsy of Breast

Excisional Biopsy of Lymph Node
type: Class
subclass of: Excisional Biopsy
subclass of: Lymph Node Biopsy
textual definition: A surgical procedure in which a single or multiple lymph nodes are removed for microscopic examination.
imported from: ncit.owl
code: C51662
Semantic_Type: Diagnostic Procedure
Preferred_Name: Excisional Biopsy of Lymph Node
UMLS_CUI: C0553989
Legacy_Concept_Name: Excisional_Biopsy_of_Lymph_Node
has exact synonym: Excisional Biopsy of Lymph Node
has exact synonym: Lymph Node Excision

Biopsy of Larynx
type: Class
subclass of: Biopsy
textual definition: Removal of tissue from the larynx for microscopic examination.
imported from: ncit.owl
code: C51663
Semantic_Type: Diagnostic Procedure
Preferred_Name: Biopsy of Larynx
UMLS_CUI: C0852790
Legacy_Concept_Name: Biopsy_of_Larynx
has exact synonym: Biopsy of Larynx
has exact synonym: Laryngeal Biopsy

Radical Neck Dissection
type: Class
subclass of: Neck Dissection
textual definition: A surgical procedure in which all the ipsilateral cervical lymph node groups of the neck, internal jugular vein, sternocleidomastoid muscle, spinal accessory nerve, and submandibular gland are removed.
imported from: ncit.owl
code: C51759
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Radical Neck Dissection
UMLS_CUI: C0034542
Contributing_Source: CPTAC
Legacy_Concept_Name: Radical_Neck_Dissection
has exact synonym: Radical Neck Dissection
in subset: NCIT C156952
in subset: NCIT C156953
in subset: NCIT C159419

Biopsy of Nasopharynx
type: Class
subclass of: Biopsy
textual definition: Removal of tissue from the nasopharynx for microscopic examination.
imported from: ncit.owl
code: C51768
Semantic_Type: Diagnostic Procedure
Preferred_Name: Biopsy of Nasopharynx
UMLS_CUI: C0396352
Legacy_Concept_Name: Biopsy_of_Nasopharynx
has exact synonym: Biopsy of Nasopharynx
has exact synonym: Nasopharyngeal Biopsy

Selective Neck Dissection of Cervical Lymph Nodes
type: Class
subclass of: Neck Dissection
textual definition: A surgical procedure in which the fibrofatty contents of the neck are removed in patients with clinically negative nodal disease in which there is a high risk of occult metastases.
imported from: ncit.owl
code: C51786
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Selective Neck Dissection of Cervical Lymph Nodes
UMLS_CUI: C0398397
Legacy_Concept_Name: Selective_Neck_Dissection_of_Cervical_Lymph_Nodes
has exact synonym: Selective Neck Dissection of Cervical Lymph Nodes

Excision of Lesion of Skin
type: Class
subclass of: Excision
textual definition: The surgical removal a of skin lesion.
imported from: ncit.owl
code: C51892
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Excision of Lesion of Skin
UMLS_CUI: C0191322
Legacy_Concept_Name: Excision_of_Lesion_of_Skin
has exact synonym: Excision of Lesion of Skin

Pelvic Lymphadenectomy
type: Class
subclass of: Regional Lymph Node Dissection
textual definition: Surgical removal of one or more pelvic lymph nodes.
imported from: ncit.owl
code: C51896
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Pelvic Lymphadenectomy
UMLS_CUI: C0193883
Contributing_Source: NCCN
ALT_DEFINITION: Surgery to remove lymph nodes in the pelvis for examination under a microscope to see if they contain cancer.
Legacy_Concept_Name: Pelvic_Lymphadenectomy
has exact synonym: Excision Pelvic Lymph Nodes
has exact synonym: Pelvic Lymph Node Dissection
has exact synonym: Pelvic Lymphadenectomy
has exact synonym: pelvic lymphadenectomy

Lymph Node Biopsy
type: Class
subclass of: Biopsy
textual definition: A test in which a lymph node or a piece of a lymph node is removed for examination under a microscope for signs of infection or disease such as cancer.
imported from: ncit.owl
code: C51900
Semantic_Type: Diagnostic Procedure
Display_Name: Lymph Node Biopsy
Preferred_Name: Lymph Node Biopsy
UMLS_CUI: C0193842
Contributing_Source: CTRP
Legacy_Concept_Name: Lymph_Node_Biopsy
has exact synonym: Biopsy of Lymph Node
has exact synonym: Lymph Node Biopsy
in subset: NCIT C116977
in subset: NCIT C118169

Modified Radical Neck Dissection
type: Class
subclass of: Neck Dissection
textual definition: A surgical procedure in which all the ipsilateral cervical lymph node groups of the neck are removed but the internal jugular vein, sternocleidomastoid muscle, and/or spinal accessory nerve are preserved.
imported from: ncit.owl
code: C51904
Semantic_Type: Therapeutic or Preventive Procedure
Display_Name: Modified Radical Neck Dissection
Preferred_Name: Modified Radical Neck Dissection
UMLS_CUI: C0193864
Contributing_Source: CPTAC
Contributing_Source: CTRP
Legacy_Concept_Name: Modified_Radical_Neck_Dissection
has exact synonym: Modified Radical Neck Dissection
in subset: NCIT C116977
in subset: NCIT C118169
in subset: NCIT C156952
in subset: NCIT C156953
in subset: NCIT C159419

Biopsy of Mucosa
type: Class
subclass of: Biopsy
textual definition: Removal of mucosal tissue for microscopic examination.
imported from: ncit.owl
code: C51922
Semantic_Type: Diagnostic Procedure
Preferred_Name: Biopsy of Mucosa
UMLS_CUI: C0852695
Legacy_Concept_Name: Biopsy_of_Mucosa
has exact synonym: Biopsy of Mucosa
has exact synonym: Mucosal Biopsy

Adjuvant Radiation Therapy
type: Class
subclass of: Radiation Therapy
textual definition: Radiation therapy that is administered subsequent to the main treatment plan to minimize or prevent disease recurrence.
imported from: ncit.owl
code: C51987
Semantic_Type: Therapeutic or Preventive Procedure
Display_Name: Adjuvant Radiation Therapy
Preferred_Name: Adjuvant Radiation Therapy
UMLS_CUI: C1706721
Contributing_Source: CTRP
Legacy_Concept_Name: Adjuvant_Radiation_Therapy
has exact synonym: Adjuvant Radiation Therapy
in subset: NCIT C116977
in subset: NCIT C118169

Axillary Lymph Node Biopsy
type: Class
subclass of: Excisional Biopsy of Lymph Node
textual definition: Surgical removal of tissues from the lymph nodes located in the cavity beneath the junction of the arm and the thorax (armpit) so that a biopsy can be performed.
imported from: ncit.owl
code: C62658
Semantic_Type: Diagnostic Procedure
Display_Name: Axillary Lymph Node Biopsy
Preferred_Name: Axillary Lymph Node Biopsy
UMLS_CUI: C0398434
Contributing_Source: CTRP
Legacy_Concept_Name: Axillary_Node_Biopsy
has exact synonym: Axillary Lymph Node Biopsy
has exact synonym: Axillary Node Biopsy
in subset: NCIT C116977
in subset: NCIT C118169

Systemic Chemotherapy
type: Class
subclass of: Chemotherapy
subclass of: Pharmacotherapy
textual definition: Chemotherapy where the agent travels throughout the body by blood circulation.
imported from: ncit.owl
code: C64261
Semantic_Type: Therapeutic or Preventive Procedure
Display_Name: Systemic Chemotherapy
Preferred_Name: Systemic Chemotherapy
UMLS_CUI: C1883256
Contributing_Source: CTRP
ALT_DEFINITION: Treatment with anticancer drugs that travel through the blood to cells all over the body.
Legacy_Concept_Name: Systemic_Chemotherapy
has exact synonym: Systemic Chemotherapy
has exact synonym: systemic chemotherapy
in subset: NCIT C116977
in subset: NCIT C118169

Vemurafenib
type: Class
subclass of: Antineoplastic Enzyme Inhibitor
subclass of: BRAF Inhibitor
textual definition: An orally bioavailable, ATP-competitive, small-molecule inhibitor of BRAF(V600E) kinase with potential antineoplastic activity. Vemurafenib selectively binds to the ATP-binding site of BRAF(V600E) kinase and inhibits its activity, which may result in an inhibition of an over-activated MAPK signaling pathway downstream in BRAF(V600E) kinase-expressing tumor cells and a reduction in tumor cell proliferation. Approximately 90% of BRAF gene mutations involve a valine-to-glutamic acid mutation at residue 600 (V600E); the oncogene protein product, BRAF(V600E) kinase, exhibits a markedly elevated activity that over-activates the MAPK signaling pathway. The BRAF(V600E) gene mutation has been found to occur in approximately 60% of melanomas, and in about 8% of all solid tumors, including melanoma, colorectal, thyroid and other cancers.
imported from: ncit.owl
Has_Target: NCIT C17476
code: C64768
Semantic_Type: Organic Chemical
Semantic_Type: Pharmacologic Substance
Display_Name: Vemurafenib
Preferred_Name: Vemurafenib
UMLS_CUI: C1832009
CAS_Registry: 918504-65-1
Accepted_Therapeutic_Use_For: Advanced Melanoma
FDA_UNII_Code: 207SMY3FQT
Contributing_Source: CTRP
Contributing_Source: FDA
ALT_DEFINITION: A substance being studied in the treatment of cancer. BRAF (V600E) kinase is a mutated (changed) form of a cell protein called BRAF. It is found in several types of cancer, including melanoma (a type of skin cancer). Inhibiting this kinase may cause cancer cells to die. BRAF (V600E) kinase is a type of serine/threonine kinase inhibitor and a type of targeted therapy agent.
PDQ_Open_Trial_Search_ID: 528954
PDQ_Closed_Trial_Search_ID: 528954
Chemical_Formula: C23H18ClF2N3O3S
Legacy_Concept_Name: PLX4032
CHEBI_ID: CHEBI:63637
has exact synonym: 1-propanesulfonamide, n-(3-((5-(4-chlorophenyl)-1h-pyrrolo(2,3-b)pyridin-3-yl)carbonyl)-2,4-difluorophenyl)-
has exact synonym: BRAF (V600E) kinase inhibitor RO5185426
has exact synonym: BRAF(V600E) Kinase Inhibitor RO5185426
has exact synonym: PLX-4032
has exact synonym: PLX4032
has exact synonym: RG 7204
has exact synonym: RG7204
has exact synonym: RO 5185426
has exact synonym: VEMURAFENIB
has exact synonym: Vemurafenib
has exact synonym: Zelboraf
in subset: NCIT C116977
in subset: NCIT C116978
in subset: NCIT C128784
in subset: NCIT C157711
in subset: NCIT C157712
in subset: NCIT C63923

Diagnostic Surgical Procedure
type: Class
subclass of: Surgical Procedure by Type
subclass of: Diagnostic Procedure
imported from: ncit.owl
code: C64979
Semantic_Type: Diagnostic Procedure
Display_Name: Diagnostic Surgical Procedure
Preferred_Name: Diagnostic Surgical Procedure
UMLS_CUI: C0522769
Contributing_Source: CTRP
Legacy_Concept_Name: Diagnostic_Surgical_Procedure
has exact synonym: Diagnostic Surgical Procedure
in subset: NCIT C116977
in subset: NCIT C118169

Therapeutic Surgical Procedure
type: Class
subclass of: Surgical Procedure
subclass of: Therapeutic Procedure
textual definition: A therapeutic procedure performed by manual and/or instrumental means, generally involving an incision and the removal or replacement of a diseased organ or tissue.
imported from: ncit.owl
code: C64982
Semantic_Type: Therapeutic or Preventive Procedure
Display_Name: Therapeutic Surgical Procedure
Preferred_Name: Therapeutic Surgical Procedure
UMLS_CUI: C1883301
Contributing_Source: CTRP
Legacy_Concept_Name: Therapeutic_Surgical_Procedure
has exact synonym: Therapeutic Surgical Procedure
in subset: NCIT C116977
in subset: NCIT C118169

Diagnostic Lymphadenectomy
type: Class
subclass of: Lymphadenectomy
subclass of: Diagnostic Surgical Procedure
imported from: ncit.owl
code: C64983
Semantic_Type: Diagnostic Procedure
Display_Name: Diagnostic Lymphadenectomy
Preferred_Name: Diagnostic Lymphadenectomy
UMLS_CUI: C1880305
Contributing_Source: CTRP
Legacy_Concept_Name: Diagnostic_Lymphadenectomy
has exact synonym: Diagnostic Lymphadenectomy
in subset: NCIT C116977
in subset: NCIT C118169

Therapeutic Lymphadenectomy
type: Class
subclass of: Lymphadenectomy
subclass of: Therapeutic Surgical Procedure
imported from: ncit.owl
code: C65003
Semantic_Type: Therapeutic or Preventive Procedure
Display_Name: Therapeutic Lymphadenectomy
Preferred_Name: Therapeutic Lymphadenectomy
UMLS_CUI: C1883298
Contributing_Source: CTRP
Legacy_Concept_Name: Therapeutic_Lymphadenectomy
has exact synonym: Therapeutic Lymphadenectomy
in subset: NCIT C116977
in subset: NCIT C118169

Nivolumab
type: Class
subclass of: Anti-PD1 Monoclonal Antibody
subclass of: Antineoplastic Biological Agent
textual definition: A fully human immunoglobulin (Ig) G4 monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed death-1 (PD-1, PCD-1) with immune checkpoint inhibitory and antineoplastic activities. Upon administration, nivolumab binds to and blocks the activation of PD-1, an immunoglobulin superfamily (IgSF) transmembrane protein, by its ligands programmed cell death ligand 1 (PD-L1), which is overexpressed on certain cancer cells, and programmed cell death ligand 2 (PD-L2), which is primarily expressed on antigen-presenting cells (APCs). This results in the activation of T-cells and cell-mediated immune responses against tumor cells. Activated PD-1 negatively regulates T-cell activation and plays a key role in tumor evasion from host immunity.
imported from: ncit.owl
Has_Target: NCIT C94697
code: C68814
Semantic_Type: Amino Acid, Peptide, or Protein
Semantic_Type: Immunologic Factor
Semantic_Type: Pharmacologic Substance
Display_Name: Nivolumab
Preferred_Name: Nivolumab
UMLS_CUI: C3657270
CAS_Registry: 946414-94-4
Accepted_Therapeutic_Use_For: locally advanced or metastatic urothelial carcinoma; recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN); renal cell carcinoma (RCC) ; metastatic melanoma; non-small cell lung cancer (NSCLC); classical Hodgkin lymphoma (cHL); BRAF V600 wild-type, unresectable or metastatic melanoma; metastatic small cell lung cancer (SCLC) with progression after platinum-based chemotherapy and at least one other line of therapy.
FDA_UNII_Code: 31YO63LBSN
Contributing_Source: CTRP
Contributing_Source: FDA
PDQ_Open_Trial_Search_ID: 539733
PDQ_Closed_Trial_Search_ID: 539733
Legacy_Concept_Name: Anti-PD-1_Human_Monoclonal_Antibody_MDX-1106
has exact synonym: BMS-936558
has exact synonym: MDX-1106
has exact synonym: NIVO
has exact synonym: NIVOLUMAB
has exact synonym: Nivolumab
has exact synonym: ONO-4538
has exact synonym: Opdivo
in subset: NCIT C116977
in subset: NCIT C116978
in subset: NCIT C128784
in subset: NCIT C157711
in subset: NCIT C157712
in subset: NCIT C63923

Cobimetinib
type: Class
subclass of: Antineoplastic Enzyme Inhibitor
subclass of: Mitogen-Activated Protein Kinase Kinase Inhibitor
textual definition: An orally bioavailable small-molecule inhibitor of mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. Cobimetinib specifically binds to and inhibits the catalytic activity of MEK1, resulting in inhibition of extracellular signal-related kinase 2 (ERK2) phosphorylation and activation and decreased tumor cell proliferation. Preclinical studies have demonstrated that this agent is effective in inhibiting the growth of tumor cells bearing a B-RAF mutation, which has been found to be associated with many tumor types. A threonine-tyrosine kinase and a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors, MEK1 is required for the transmission of growth-promoting signals from numerous receptor tyrosine kinases.
imported from: ncit.owl
code: C68923
Semantic_Type: Pharmacologic Substance
Display_Name: Cobimetinib
Preferred_Name: Cobimetinib
UMLS_CUI: C2346910
Accepted_Therapeutic_Use_For: unresectable or metastatic melanoma with BRAF V600E or V600K mutation
FDA_UNII_Code: ER29L26N1X
Contributing_Source: CTRP
Contributing_Source: FDA
PDQ_Open_Trial_Search_ID: 551654
PDQ_Closed_Trial_Search_ID: 551654
Legacy_Concept_Name: MEK_Inhibitor_XL518
has exact synonym: COBIMETINIB
has exact synonym: Cobimetinib
has exact synonym: Cotellic
has exact synonym: GDC-0973
has exact synonym: MEK Inhibitor GDC-0973
has exact synonym: XL518
in subset: NCIT C116977
in subset: NCIT C116978
in subset: NCIT C128784
in subset: NCIT C157711
in subset: NCIT C157712
in subset: NCIT C63923

Mitogen-Activated Protein Kinase Kinase Inhibitor
type: Class
subclass of: Protein Kinase Inhibitor
textual definition: Any substance that inhibits mitogen-activated protein kinase kinase (MEK), an enzyme that catalyzes the addition of a phosphate group to a mitogen-activated protein kinase. Inhibition of mitogen-activated protein kinase kinase results in the inhibition of cell proliferation.
imported from: ncit.owl
code: C69145
Semantic_Type: Chemical Viewed Functionally
Display_Name: Mitogen-Activated Protein Kinase Kinase Inhibitor
Preferred_Name: Mitogen-Activated Protein Kinase Kinase Inhibitor
UMLS_CUI: C2347168
Contributing_Source: CTRP
Legacy_Concept_Name: Mitogen-Activated_Protein_Kinase_Kinase_Inhibitor
has exact synonym: MAP2K Inhibitor
has exact synonym: MAPK/ERK Kinase Inhibitor
has exact synonym: MAPKK Inhibitor
has exact synonym: MEK Inhibitor
has exact synonym: MKK Inhibitor
has exact synonym: Mitogen-Activated Protein Kinase Kinase Inhibitor
in subset: NCIT C116977
in subset: NCIT C116978

Inguinofemoral Lymphadenectomy
type: Class
subclass of: Regional Lymph Node Dissection
textual definition: The surgical removal of superficial inguinal lymph nodes and deep femoral lymph nodes.
imported from: ncit.owl
code: C74540
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Inguinofemoral Lymphadenectomy
UMLS_CUI: C0398408
Legacy_Concept_Name: Inguinofemoral_Lymphadenectomy
DesignNote: This surgery is used in the treatment of vulvar cancers.
has exact synonym: Inguinofemoral Lymphadenectomy

Trametinib
type: Class
subclass of: Antineoplastic Enzyme Inhibitor
subclass of: Mitogen-Activated Protein Kinase Kinase Inhibitor
textual definition: An orally bioavailable inhibitor of mitogen-activated protein kinase kinase (MEK MAPK/ERK kinase) with potential antineoplastic activity. Trametinib specifically binds to and inhibits MEK 1 and 2, resulting in an inhibition of growth factor-mediated cell signaling and cellular proliferation in various cancers. MEK 1 and 2, dual specificity threonine/tyrosine kinases often upregulated in various cancer cell types, play a key role in the activation of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth.
imported from: ncit.owl
code: C77908
Semantic_Type: Organic Chemical
Semantic_Type: Pharmacologic Substance
Display_Name: Trametinib
Preferred_Name: Trametinib
UMLS_CUI: C2697961
CAS_Registry: 871700-17-3
Accepted_Therapeutic_Use_For: metastatic non-small cell lung cancer (NSCLC) with BRAF V600E mutation; unresectable or metastatic melanoma with BRAF V600E or V600K mutations
FDA_UNII_Code: 33E86K87QN
Contributing_Source: CTRP
Contributing_Source: FDA
PDQ_Open_Trial_Search_ID: 599034
PDQ_Closed_Trial_Search_ID: 599034
Chemical_Formula: C26H23FIN5O4
Legacy_Concept_Name: MEK_Inhibitor_GSK1120212
has exact synonym: GSK1120212
has exact synonym: JTP-74057
has exact synonym: MEK Inhibitor GSK1120212
has exact synonym: Mekinist
has exact synonym: N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide
has exact synonym: TRAMETINIB
has exact synonym: Trametinib
in subset: NCIT C116977
in subset: NCIT C116978
in subset: NCIT C128784
in subset: NCIT C157711
in subset: NCIT C157712
in subset: NCIT C63923

Dabrafenib
type: Class
subclass of: Antineoplastic Enzyme Inhibitor
subclass of: BRAF Inhibitor
textual definition: An orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations.
imported from: ncit.owl
code: C82386
Semantic_Type: Pharmacologic Substance
Display_Name: Dabrafenib
Preferred_Name: Dabrafenib
UMLS_CUI: C3467876
CAS_Registry: 1195765-45-7
Accepted_Therapeutic_Use_For: metastatic non-small cell lung cancer (NSCLC) with BRAF V600E mutation
FDA_UNII_Code: QGP4HA4G1B
Contributing_Source: CTRP
Contributing_Source: FDA
PDQ_Open_Trial_Search_ID: 641977
PDQ_Closed_Trial_Search_ID: 641977
Chemical_Formula: C23H20F3N5O2S2
Legacy_Concept_Name: BRAF_Inhibitor_GSK2118436
has exact synonym: BRAF Inhibitor GSK2118436
has exact synonym: Benzenesulfonamide, N-(3-(5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl)-2-fluorophenyl)-2,6-difluoro-
has exact synonym: DABRAFENIB
has exact synonym: Dabrafenib
has exact synonym: GSK-2118436
has exact synonym: GSK-2118436A
has exact synonym: GSK2118436
in subset: NCIT C116977
in subset: NCIT C116978
in subset: NCIT C128784
in subset: NCIT C157711
in subset: NCIT C157712
in subset: NCIT C63923

Binimetinib
type: Class
subclass of: Antineoplastic Enzyme Inhibitor
subclass of: Mitogen-Activated Protein Kinase Kinase Inhibitor
textual definition: An orally available inhibitor of mitogen-activated protein kinase kinase 1 and 2 (MEK1/2) with potential antineoplastic activity. Binimetinib, noncompetitive with ATP, binds to and inhibits the activity of MEK1/2. Inhibition of MEK1/2 prevents the activation of MEK1/2 dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling. This may eventually lead to an inhibition of tumor cell proliferation and an inhibition in production of various inflammatory cytokines including interleukin-1, -6 and tumor necrosis factor. MEK1/2 are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types.
imported from: ncit.owl
code: C84865
Semantic_Type: Pharmacologic Substance
Display_Name: Binimetinib
Preferred_Name: Binimetinib
UMLS_CUI: C2830125
Accepted_Therapeutic_Use_For: in combination with encorafenib, for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation
FDA_UNII_Code: 181R97MR71
Contributing_Source: CTRP
Contributing_Source: FDA
PDQ_Open_Trial_Search_ID: 653635
PDQ_Closed_Trial_Search_ID: 653635
has exact synonym: ARRY-162
has exact synonym: ARRY-438162
has exact synonym: BINIMETINIB
has exact synonym: Binimetinib
has exact synonym: MEK162
has exact synonym: Mektovi
in subset: NCIT C116977
in subset: NCIT C116978
in subset: NCIT C128784
in subset: NCIT C157711
in subset: NCIT C157712
in subset: NCIT C63923

Isolated Chemotherapeutic Lung Perfusion
type: Class
subclass of: Isolated Chemotherapeutic Perfusion
imported from: ncit.owl
code: C93273
Semantic_Type: Therapeutic or Preventive Procedure
Display_Name: Pulmonary Suffusion
Preferred_Name: Isolated Chemotherapeutic Lung Perfusion
UMLS_CUI: C2985528
Contributing_Source: CTRP
ALT_DEFINITION: A surgical procedure during which the circulation of blood to the lungs is separated from the circulation of blood through the rest of the body, and a drug is delivered directly into the lung circulation. This allows a higher concentration of chemotherapy to reach tumors in the lungs.
has exact synonym: Isolated Chemotherapeutic Lung Perfusion
has exact synonym: Pulmonary Suffusion
has exact synonym: isolated lung perfusion
in subset: NCIT C116977
in subset: NCIT C118169

Chemoimmunotherapy
type: Class
subclass of: Cancer Immunotherapy
imported from: ncit.owl
code: C94251
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Chemoimmunotherapy
UMLS_CUI: C2986423
ALT_DEFINITION: Chemotherapy combined with immunotherapy. Chemotherapy uses different drugs to kill or slow the growth of cancer cells; immunotherapy uses treatments to stimulate or restore the ability of the immune system to fight cancer.
has exact synonym: Chemoimmunotherapy
has exact synonym: chemoimmunotherapy

Radical Local Excision
type: Class
subclass of: Excision
imported from: ncit.owl
code: C94449
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Radical Local Excision
UMLS_CUI: C2986520
ALT_DEFINITION: Surgery to remove a tumor and a large amount of normal tissue surrounding it. Nearby lymph nodes may also be removed.
has exact synonym: Radical Local Excision
has exact synonym: radical local excision

Molecular Sequence Variation
type: Class
subclass of: Molecular Abnormality
textual definition: A variation in or modification of the molecular sequence of a gene or gene product.
imported from: ncit.owl
code: C97926
Semantic_Type: Cell or Molecular Dysfunction
Preferred_Name: Molecular Sequence Variation
UMLS_CUI: C3273703
has exact synonym: Molecular Sequence Variation

Gene Mutant
type: Class
subclass of: Molecular Genetic Variation
textual definition: A variation in the nucleic acid sequence of a specific gene.
imported from: ncit.owl
code: C97927
Semantic_Type: Cell or Molecular Dysfunction
Preferred_Name: Gene Mutant
UMLS_CUI: C0678941
has exact synonym: Gene Mutant
has exact synonym: Gene Mutation
has exact synonym: Gene Variant

Gene Product Sequence Variation
type: Class
subclass of: Molecular Sequence Variation
textual definition: A variation in the amino acid sequence of a specific gene product.
imported from: ncit.owl
code: C97928
Semantic_Type: Cell or Molecular Dysfunction
Preferred_Name: Gene Product Sequence Variation
UMLS_CUI: C3273704
has exact synonym: Gene Product Sequence Variation

Encorafenib
type: Class
subclass of: Antineoplastic Enzyme Inhibitor
subclass of: BRAF Inhibitor
textual definition: An orally available Raf kinase inhibitor with potential antineoplastic activity. Encorafenib specifically inhibits Raf kinase, a serine/threonine enzyme in the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway. By inhibiting the activation of the RAF/MEK/ERK signaling pathway, the administration of LGX818 may result in a decrease in proliferation of tumor cells. The Raf mutation BRAF V600E is frequently upregulated in a variety of human tumors and results in the constitutive activation of the RAF/MEK/ERK signaling pathway that regulates cellular proliferation and survival.
imported from: ncit.owl
code: C98283
Semantic_Type: Organic Chemical
Semantic_Type: Pharmacologic Substance
Display_Name: Encorafenib
Preferred_Name: Encorafenib
UMLS_CUI: C4079208
CAS_Registry: 1269440-17-6
Accepted_Therapeutic_Use_For: in combination with binimetinib, for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation
FDA_UNII_Code: 8L7891MRB6
Contributing_Source: CTRP
Contributing_Source: FDA
PDQ_Open_Trial_Search_ID: 712549
PDQ_Closed_Trial_Search_ID: 712549
has exact synonym: Braftovi
has exact synonym: ENCORAFENIB
has exact synonym: Encorafenib
has exact synonym: LGX 818
has exact synonym: LGX-818
has exact synonym: LGX818
in subset: NCIT C116977
in subset: NCIT C116978
in subset: NCIT C128784
in subset: NCIT C157711
in subset: NCIT C157712
in subset: NCIT C63923

BRAF Protein Variant
type: Class
subclass of: Gene Product Sequence Variation
textual definition: A variation in the amino acid sequence for the serine/threonine-protein kinase B-raf protein.
imported from: ncit.owl
code: C98307
Semantic_Type: Cell or Molecular Dysfunction
Display_Name: BRAF Protein Variant
Preferred_Name: BRAF Protein Variant
UMLS_CUI: C3273955
Contributing_Source: CTRP
has exact synonym: BRAF Protein Variant
has exact synonym: Serine/Threonine-Protein Kinase B-raf Protein Variant
in subset: NCIT C116977
in subset: NCIT C142799
in subset: NCIT C142800

Complication
type: Class
subclass of: melanoma ontology
textual definition: a pathological bodily process that occurs after a medical intervention. An adverse event is likely caused by the medical intervention; however, such a causal association is not required to be an adverse event.
editor note: Melanie Courtot and YH: More work is needed on how to restrict the scope of a term to be an 'adverse event', notably regarding temporal association. When is an appropirate time interval between a medical intervention and an adverse event observed? One week, one month, one year, or a lifetime? For some well-studied medical interventions (e.g., administration of many vaccines or drugs), we probably have a general idea. For many new interventions, we don't know much. In OAE, this issue is associated with defining the 'adverse event incubation time'.
editor note: YH: An adverse event is a process that has specified output of some adverse medical outcome (e.g., symptom, sign or accident) after a medical intervention (or process) (e.g., administration of drug or vaccine). The medical intervention can be an administration of a drug, a vaccine (i.e., vaccination), or a special nutritional product (for example, dietary supplement, infant formula, medical food), surgery, or usage of a medical device.
editor note: YH: An adverse event is possibly induced by the medical intervention. It can be caused by the medical intervention, or may not be caused by the medical intervention. One ultimate goal (or the goal in clinics) of study adverse events is to assess if the adverse event outcome is due to the medical intervention.
editor note: YH: In development of OAE, we initially use vaccine adverse event as our use case. A vaccine adverse event is associated with a vaccination (i.e. a medical intervention), regardless of whether it is considered vaccine-related, and includes any side effect, injury, toxicity, or sensitivity reaction or significant failure of immunization (i.e., a pharmacologic action). Ref: Baylor NW and Midthum K. Regulation and testing of vaccines. In: Vaccines (Editors: Plotkin S, Orenstein W, and Offit P). 2008. p1623.
editor note: YH: The current term 'adverse event' is different from the term definition shown in our paper: He Y, Xiang Z, Sarntivijai S, Toldo L, Ceusters W. OAE: a realism-based biomedical ontology for the representation of adverse events. Adverse Event Representation Workshop, International Conference on Biomedical Ontologies (ICBO), University at Buffalo, NY, July 26-30, 2011. Full lenghth conference proceeding paper. We made the name changing in order to make OAE cover the broader sense of the 'adverse event' which does not assume definite causal effect between an adverse event and a medical intervention. In current definition, the adverse event emphasizes the time association and assumes a likelihood of such a causal association. This term 'adverse event' is stil under the OGMS:pathological bodily process. The 'adverse event' defined in the above paper has now been changed to a new term: 'causal adverse event'. See more information in the new publication: Yongqun He Y, Sirarat Sarntivijai, Yu Lin, Zuoshuang Xiang, Abra Guo, Shelley Zhang, Desikan Jagannathan, Luca Toldo, Cui Tao and Barry Smith. OAE: The Ontology of Adverse Events. Journal of Biomedical Semantics. 2014, 5:29 doi:10.1186/2041-1480-5-29. PMID: 25093068.PMCID: PMC4120740.
editor note: YH: The main scope of OAE includes: (1) represent terms and relations in the area of adverse events, (2) assess possible associations between an adverse event and a medical intervention, particularly, identify any causal effect of a medical intervention to an adverse event; and (2) understand the mechanism (including molecular mechanisms) of causal adverse events.
editor note: YH: There has been discussion regarding whether the term 'side effect' is an alternative term for 'adverse event'. In AERO, the term 'AERO:adverse event' represents a subset of those adverse events for which causality has been established. In OAE, an adverse event for which causality has been established is called 'causal adverse event'.
definition editor: Yongqun He
alternative term: AE
alternative term: adverse reaction
definition source: WEB: http://en.wikipedia.org/wiki/Adverse_event
definition source: WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/25093068
imported from: oae.owl
comment: The OAE official website is: http://www.oae-ontology.org/.

musculoskeletal or connective tissue AE
type: Class
subclass of: Complication
textual definition: an adverse event that has an outcome of abnormal sign in a musculoskeletal or connective tissue.
definition editor: YH, RR, JX
alternative term: musculoskeletal and connective tissue disorder AE
definition source: WEB: http://www.cdc.gov/niosh/programs/msd/
imported from: oae.owl
has_MedDRA_id: 10028395
comment: A musculoskeletal disorder is an injury or disorder of the muscles, nerves, tendons, joints, cartilage, or supporting structures of the upper or lower limbs, neck, or lower back that are caused, precipitated, or exacerbated by sudden exertion or prolonged exposure to physical factors such as repetition, force, vibration, or awkward posture
see also: CTCAE: E13872

metabolism, endocrine or exocrine system AE
type: Class
subclass of: Complication
textual definition: an adverse event which occurs in a metabolism process (including anabolism and catabolism), endocrine system, or exocrine system.
definition editor: SS, YH, JX
alternative term: metabolism, endocrine, and exocrine system AE
imported from: oae.owl
has_MedDRA_id: 10027433
see also: MP: 0005266

vascular disorder AE
type: Class
subclass of: cardiovascular AE
textual definition: a cardiovascular disorder AE that has a vascular disorder outcome
imported from: oae.owl
has_MedDRA_id: 10047065

thrombosis AE
type: Class
subclass of: vascular disorder AE
textual definition: A vascular disorder AE that results in the presence of blood clot along the wall of a blood vessel, frequently causing vascular obstruction. Some authorities differentiate thrombus formation from simple coagulation or clot formation.
definition editor: SS, YH, MW
imported from: oae.owl
Chinese translation: 血栓症; 血栓生成
has_MedDRA_id: 10043607
see also: HPO: HP_0004419
see also: SIDER: C0040053

endocrine system AE
type: Class
subclass of: metabolism, endocrine or exocrine system AE
textual definition: a metabolism, endocrine, and exocrine system AE that occurs in endocrine system.
imported from: oae.owl
has_MedDRA_id: 10014698
creator: YH, SS

respiratory system AE
type: Class
subclass of: Complication
textual definition: an AE that occurs in respiratory system.
editor note: I created this term and make it to be an umbrella term for different disorder terms related to respiratory system. --Oliver He
definition editor: YH
imported from: oae.owl

central serous retinopathy AE
type: Class
subclass of: abnormal vision AE
textual definition: an abnormal vision AE characterised by leakage of fluid under the retina causing visual impairment, usually in one eye.
definition editor: SJ, YH
alternative term: central serous chorioretinopathy
definition source: WEB: http://en.wikipedia.org/wiki/Central_serous_retinopathy
imported from: oae.owl
has_MedDRA_id: 10063118

febrile seizure AE
type: Class
subclass of: seizure AE
textual definition: a seizure AE that has an outcome of a seizure disorder associated with an elevated temperature
definition editor: YH, BY
definition source: http://emedicine.medscape.com/article/1176205-overview
imported from: oae.owl

hemorrhage AE
type: Class
subclass of: cardiovascular AE
textual definition: a cardiovascular disorder AE that has an outcome of hemorrhage
alternative term: bleeding AE
alternative term: haemorrhage AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hemorrhage
imported from: oae.owl
has_MedDRA_id: 10055798
comment: loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels
see also: MP: MP_0001914

lung AE
type: Class
subclass of: respiratory system AE
textual definition: a respiratory system AE which has an outcome of lung disorder
definition editor: YH
alternative term: lung disorder AE
imported from: oae.owl
has_MedDRA_id: 10025082
see also: HPO: HP_0006552
see also: SIDER: C0024115

muscle AE
type: Class
subclass of: musculoskeletal or connective tissue AE
textual definition: a musculoskeletal system AE that occurs in muscle.
definition editor: YH
imported from: oae.owl

eye AE
type: Class
subclass of: Complication
textual definition: an AE that occurs in eye.
definition editor: YH
alternative term: eye disorder AE
imported from: oae.owl
has_MedDRA_id: 10015916
see also: HPO: HP_0000496
see also: SIDER: C0015397

immune system AE
type: Class
subclass of: Complication
textual definition: an AE that occurs in immune system.
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'immune system disorder' was mentioned in 292 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
definition editor: YH
alternative term: immune system disorder AE
imported from: oae.owl
see also: HPO: HP_0002715
see also: SIDER: C0021053

cardiovascular AE
type: Class
subclass of: Complication
textual definition: an AE that occurs in cardiovascular system.
definition editor: YH
alternative term: cardiovascular disorder AE
imported from: oae.owl
has_MedDRA_id: 10007649
see also: HPO: HP_0001626
see also: SIDER: C0007222

diabetes mellitus AE
type: Class
subclass of: glucose homeostasis AE
textual definition: a glucose homeostasis AE which has an outcome of diabetes mellitus
definition editor: YH
alternative term: diabetes AE
imported from: oae.owl
has_MedDRA_id: 10012601
comment: Diabetes mellitus, often referred to simply as diabetes, is a syndrome of disordered metabolism, usually due to a combination of hereditary and environmental causes, resulting in abnormally high blood sugar levels (hyperglycemia).
see also: HPO: HP_0000819
see also: SIDER: C0011849

hyperglycemia AE
type: Class
subclass of: glucose homeostasis AE
textual definition: a glucose homeostasis AE which has an outcome of hyperglycemia, which is an abnormally high concentration of glucose in the blood; generally refers to a pathological state
definition editor: YH, MW
definition source: WEB: http://medical-dictionary.thefreedictionary.com/hyperglycemia
imported from: oae.owl
has_MedDRA_id: 10020635
has_MedDRA_id: 10020639
see also: CTCAE: E12276
see also: MP: MP_0001559
see also: NCIt: C26797

homeostasis AE
type: Class
subclass of: Complication
textual definition: an AE that occurs in the homeostasis system.
imported from: oae.owl
comment: anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the fluids and tissues
see also: MP: MP_0001764

inflammation AE
type: Class
subclass of: immune system AE
textual definition: an immune system disorder AE that results in complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. Inflammation is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process for the tissue greater than expected response to injury, infection, or insult.
definition editor: SS, YH
definition source: WEB: http://en.wikipedia.org/wiki/Inflammation
imported from: oae.owl
has_MedDRA_id: 10061218
see also: HPO: HP_0007891
see also: MP: MP_0001846
see also: SIDER: C0021368

brain inflammation AE
type: Class
subclass of: inflammation AE
textual definition: an inflammation AE which has an outcome of brain inflammation, which is local accumulation of fluid, plasma proteins, and leukocytes in the brain
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'encephalitis' is an adverse event that was mentioned in 480 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543).
imported from: oae.owl
see also: MP: MP_0001847

lung inflammation AE
type: Class
subclass of: respiratory system inflammation AE
textual definition: aa inflammation AE which has an outcome of lung inflammation, a local accumulation of fluid, plasma proteins, and leukocytes in the lung
editor note: According to the Vaccine Adverse Event Reporting System (VAERS), 'pneumonia' was mentioned in 879 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543).
imported from: oae.owl
see also: MP: MP_0001861

respiratory system inflammation AE
type: Class
subclass of: inflammation AE
textual definition: an inflammation AE which occurs in the respiratory system, which is reflected with the local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system
imported from: oae.owl
see also: MP: MP_0002405

abnormal vision AE
type: Class
subclass of: eye AE
textual definition: an eye disorder AE which has an outcome of abnormal vision, which is an inability or decreased ability to see
imported from: oae.owl
see also: MP: MP_0002090

seizure AE
type: Class
subclass of: behavioral and neurological AE
textual definition: a behavior and neurological AE that shows a sudden surge of electrical activity in the brain.
definition editor: YH, JX, YH
definition source: WEB: http://www.healthline.com/symptom/seizures
imported from: oae.owl
Chinese translation: 突然发作
has_MedDRA_id: 10039906
has_MedDRA_id: 10039910
see also: CTCAE: E12804
see also: MP: MP_0002064
see also: NCIt: C2962

behavioral and neurological AE
type: Class
subclass of: Complication
textual definition: an adverse event that has an outcome of an abnormal behavior and neurological phenotype.
definition editor: YH, JX
alternative term: behavior AE
alternative term: behavioral AE
alternative term: behavioral disorder AE
alternative term: disruptive behavioral disorder AE
definition source: WEB: http://www.psychguides.com/guides/behavioral-disorder-symptoms-causes-and-effects/
imported from: oae.owl
comment: any anomaly in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls
see also: MP: MP_0004924

glucose homeostasis AE
type: Class
subclass of: homeostasis AE
textual definition: a homeostasis AE which has an outcome of glucose homeostasis, which is an anomaly in the processes involved in the maintenance of an internal equilibrium of glucose in the fluids and tissues
imported from: oae.owl
see also: MP: MP_0002078

urinary system AE
type: Class
subclass of: Complication
textual definition: an adverse event that has an outcome of urinary system AE is a functional anomaly of any of the organs involved in the production or excretion of urine
definition editor: YH
imported from: oae.owl
see also: MP: MP_0005502

colitis AE
type: Class
subclass of: inflammation AE
textual definition: an inflammation AE that occurs at the large intestine
definition editor: DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002112/
imported from: oae.owl
has_MedDRA_id: 10009887
see also: CTCAE: E10521
see also: HPO: HP_0002583
see also: NCIt: C26723
see also: SIDER: C0009319

interstitial lung disease AE
type: Class
subclass of: lung AE
textual definition: a lung disorder AE that has an outcome of a disease affecting the interstitium, the tissue and space around the air sacs of the lungs
definition editor: SZ, DJ, SS, YH
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/23289473
imported from: oae.owl
has_MedDRA_id: 10022611
see also: HPO: HP_0006530
see also: SIDER: C0206062

pneumonitis AE
type: Class
subclass of: lung inflammation AE
textual definition: a lung inflammation AE located in the lung tissue
definition editor: SZ, SS, YH, MW
alternative term: pulmonitis AE
definition source: WEB: http://medical-dictionary.thefreedictionary.com/pneumonitis
imported from: oae.owl
has_MedDRA_id: 10035742

rhabdomyolysis AE
type: Class
subclass of: muscle AE
textual definition: a muscle adverse event that results in damaged skeletal muscle tissue breaks down rapidly
definition editor: SZ, SS, YH
definition source: WEB: http://medical-dictionary.thefreedictionary.com/rhabdomyolysis
imported from: oae.owl
has_MedDRA_id: 10039020
see also: HPO: HP_0009045
see also: SIDER: C0035410

eye inflammation AE
type: Class
subclass of: inflammation AE
textual definition: an inflammation AE that occurs in eye.
definition editor: YH, JX
imported from: oae.owl

retinal vein occlusion AE
type: Class
subclass of: thrombosis AE
textual definition: a thrombosis that is characterized by a blockage of the small veins that carry blood away from the retina. The retina is the layer of tissue at the back of the inner eye that converts light images to nerve signals and sends them to the brain.
definition editor: SS
alternative term: RVO
definition source: WEB: http://www.nlm.nih.gov/medlineplus/ency/article/007330.htm
imported from: oae.owl
has_MedDRA_id: 10038907

non-insulin-dependent diabetes mellitus AE
type: Class
subclass of: diabetes mellitus AE
textual definition: Non-insulin-dependent diabetes mellitus AE is a diabetes mellitus AE which is also called diabetes mellitus type 2, it's characterized by hyperglycemia (high blood sugar) in the context of insulin resistance and relative lack of insulin.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Diabetes_mellitus_type_2
imported from: oae.owl
Chinese translation: 非胰岛素依赖型糖尿病
has_MedDRA_id: 10029505

insulin dependent diabetes mellitus AE
type: Class
subclass of: diabetes mellitus AE
textual definition: Insulin dependent diabetes mellitus AE is a diabetes mellitus AE which is also called diabetes mellitus type 1. It results from the autoimmune destruction of the insulin-producing beta cells in the pancreas.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Diabetes_mellitus_type_1
imported from: oae.owl
Chinese translation: 胰岛素依赖型糖尿病
has_MedDRA_id: 10022497

uveitis AE
type: Class
subclass of: eye inflammation AE
textual definition: Uveitis AE is an inflammation AE that is inflammation of the uvea, which lines the inside of the eye behind the cornea.
definition editor: JX, LW, YH
definition source: WEB: http://en.wikipedia.org/wiki/Uveitis
imported from: oae.owl
Chinese translation: 色素层炎
has_MedDRA_id: 10046851
see also: CTCAE: E10442
see also: NCIt: C26909

unstable diabetes AE
type: Class
subclass of: diabetes mellitus AE
textual definition: Unstable diabetes AE is a diabetes mellitus AE that is a type of diabetes when a person's blood glucose level often swings quickly from high to low and from low to high.
definition editor: JX, LW, YH
alternative term: brittle diabetes AE
alternative term: labile diabetes AE
definition source: WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=7271
imported from: oae.owl
Chinese translation: 不稳定型糖尿病
has_MedDRA_id: 10006372

retinal detachment AE
type: Class
subclass of: eye AE
textual definition: Retinal detachment AE is an eye AE that is a separation of the retina from its attachments to the underlying tissue within the eye.
definition editor: JX, LW, YH
definition source: WEB: http://www.medicinenet.com/retinal_detachment/article.htm
imported from: oae.owl
Chinese translation: 视网膜脱离
has_MedDRA_id: 10038848
see also: CTCAE: E10420
see also: NCIT: C26874
see also: NCIt: C26874

severe rhabdomyolysis AE
type: Class
subclass of: rhabdomyolysis AE
textual definition: Severe rhabdomyolysis AE is a rhabdomyolysis AE that shows in severe damaged skeletal muscle tissue breaks down rapidly.
definition editor: JX, LW, YH
imported from: oae.owl
Chinese translation: 严重的横纹肌溶解症

encephalitis AE
type: Class
subclass of: brain inflammation AE
textual definition: Encephalitis AE is a nervous system AE that is an acute inflammation of the brain.
definition editor: JX, YH
definition source: WEB: http://en.wikipedia.org/wiki/Encephalitis
imported from: oae.owl
has_MedDRA_id: 10014581

Grade 3 pneumonitis AE
type: Class
subclass of: pneumonitis AE
textual definition: a pneumonitis AE that has severe symptoms; limiting self care ADL; oxygen indicated
definition editor: YH, MW
imported from: oae.owl
see also: CTCAE: E13505

Grade 4 pneumonitis AE
type: Class
subclass of: pneumonitis AE
textual definition: a pneumonitis AE that has life-threatening respiratory compromise; urgent intervention indicated (e.g., tracheotomy or intubation)
definition editor: YH, MW
imported from: oae.owl
see also: CTCAE: E13506

Grade 1 hyperglycemia AE
type: Class
subclass of: hyperglycemia AE
textual definition: a hypeglycemia AE that has fasting glucose value >ULN - 160 mg/dL; Fasting glucose value >ULN - 8.9 mmol/L
definition editor: YH, MW
imported from: oae.owl
see also: CTCAE: E12277

Grade 2 hyperglycemia AE
type: Class
subclass of: hyperglycemia AE
textual definition: a hypeglycemia AE that has fasting glucose value >160 - 250 mg/dL; Fasting glucose value >8.9 - 13.9 mmol/L
definition editor: YH, MW
imported from: oae.owl
see also: CTCAE: E12278

Grade 3 hyperglycemia AE
type: Class
subclass of: hyperglycemia AE
textual definition: a hypeglycemia AE that has >250 - 500 mg/dL; >13.9 - 27.8 mmol/L; hospitalization indicated
definition editor: YH, MW
imported from: oae.owl
see also: CTCAE: E12279

Grade 4 hyperglycemia AE
type: Class
subclass of: hyperglycemia AE
textual definition: a hypeglycemia AE that has >500 mg/dL; >27.8 mmol/L; life-threatening consequences
definition editor: YH, MW
imported from: oae.owl
see also: CTCAE: E12280

adrenal insufficiency AE
type: Class
subclass of: endocrine system AE
textual definition: an endocrine system AE that occurs when the adrenal cortex does not produce enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex as in Addison's disease or primary adrenal insufficiency.
definition editor: MW, YH
imported from: oae.owl
has_MedDRA_id: 10001367
see also: CTCAE: E10298
see also: NCIt: C26691

Grade 2 uveitis AE
type: Class
subclass of: uveitis AE
textual definition: an uveitis AE that has anterior uveitis; medical intervention indicated
definition editor: MW, YH
imported from: oae.owl
see also: CTCAE: E10444

Grade 3 uveitis AE
type: Class
subclass of: uveitis AE
textual definition: an uveitis AE that has posterior or pan-uveitis
definition editor: MW, YH
imported from: oae.owl
see also: CTCAE: E10445

Grade 4 uveitis AE
type: Class
subclass of: uveitis AE
textual definition: an uveitis AE that has blindness (20/200 or worse) in the affected eye
definition editor: MW, YH
imported from: oae.owl
see also: CTCAE: E10446

nephritis AE
type: Class
subclass of: urinary system AE
textual definition: A urinary system AE that is characterized by a condition in which the nephrons, the functional units of the kidneys, become inflamed.
definition editor: David Ameriguian, Oliver He
definition source: https://www.medicalnewstoday.com/articles/312579.php
imported from: oae.owl
has_MedDRA_id: 10029117

BRAF NP_004324.2:p.V600A
type: NamedIndividual
type: Individuals
textual definition: A change in the amino acid residue at position 600 in the serine/threonine protein kinase B-raf protein where valine has been replaced by alanine.
imported from: ncit.owl
code: C98338
Semantic_Type: Cell or Molecular Dysfunction
Display_Name: BRAF NP_004324.2:p.V600A
Preferred_Name: BRAF NP_004324.2:p.V600A
UMLS_CUI: C3273986
Contributing_Source: CTRP
has exact synonym: BRAF NP_004324.2:p.V600A
has exact synonym: BRAF NP_004324.2:p.Val600Ala
has exact synonym: BRAF V600A
has exact synonym: BRAF Val600Ala
has exact synonym: BRAF p.V600A
has exact synonym: BRAF p.Val600Ala
has exact synonym: NP_004324.2:p.Val600Ala
has exact synonym: Serine/Threonine-Protein Kinase B-raf V600A
has exact synonym: Serine/Threonine-Protein Kinase B-raf Val600Ala
in subset: NCIT C116977
in subset: NCIT C142799
in subset: NCIT C142800

BRAF NM_004333.4:c.1799T>C
type: NamedIndividual
type: Individuals
textual definition: A nucleotide substitution at position 1799 of the coding sequence of the BRAF gene where thymine has been mutated to cytosine.
imported from: ncit.owl
code: C98339
Semantic_Type: Cell or Molecular Dysfunction
Display_Name: BRAF NM_004333.4:c.1799T>C
Preferred_Name: BRAF NM_004333.4:c.1799T>C
UMLS_CUI: C3273987
SNP_ID: rs113488022
Contributing_Source: CTRP
has exact synonym: B-RAF1 c.1799T>C
has exact synonym: BRAF NM_004333.4:c.1799T>C
has exact synonym: BRAF c.1799T>C
has exact synonym: NM_004333.4:c.1799T>C
has exact synonym: v-raf Murine Sarcoma Viral Oncogene Homolog B1 c.1799T>C
in subset: NCIT C116977
in subset: NCIT C142799
in subset: NCIT C142800

BRAF NP_004324.2:p.V600D
type: NamedIndividual
type: Individuals
textual definition: A change in the amino acid residue at position 600 in the serine/threonine protein kinase B-raf protein where valine has been replaced by aspartic acid.
imported from: ncit.owl
code: C98340
Semantic_Type: Cell or Molecular Dysfunction
Display_Name: BRAF NP_004324.2:p.V600D
Preferred_Name: BRAF NP_004324.2:p.V600D
UMLS_CUI: C3273988
Contributing_Source: CTEP
Contributing_Source: CTRP
has exact synonym: BRAF NP_004324.2:p.V600D
has exact synonym: BRAF NP_004324.2:p.Val600Asp
has exact synonym: BRAF V600D
has exact synonym: BRAF Val600Asp
has exact synonym: BRAF p.V600D
has exact synonym: BRAF p.Val600Asp
has exact synonym: NP_004324.2:p.Val600Asp
has exact synonym: Serine/Threonine-Protein Kinase B-raf V600D
has exact synonym: Serine/Threonine-Protein Kinase B-raf Val600Asp
in subset: NCIT C116977
in subset: NCIT C142799
in subset: NCIT C142800

BRAF NM_004333.4:c.1799_1800delTGinsAT
type: NamedIndividual
type: Individuals
textual definition: A complex substitution where the nucleotide sequence at positions 1799 and 1780 of the coding sequence of the BRAF gene has changed from thymine-guanine to adenine-thymine.
imported from: ncit.owl
code: C98341
Semantic_Type: Cell or Molecular Dysfunction
Display_Name: BRAF NM_004333.4:c.1799_1800delTGinsAT
Preferred_Name: BRAF NM_004333.4:c.1799_1800delTGinsAT
UMLS_CUI: C3273989
Contributing_Source: CPTAC
Contributing_Source: CTRP
has exact synonym: B-RAF1 c.1799_1800TG>AT
has exact synonym: BRAF NM_004333.4:c.1799_1800delTGinsAT
has exact synonym: BRAF V600D (c.1799_1800TG>AT) mutation
has exact synonym: BRAF c.1799_1800TG>AT
has exact synonym: BRAF c.1799_1800delTGinsAT
has exact synonym: NM_004333.4:c.1799_1800TG>AT
has exact synonym: NM_004333.4:c.1799_1800delTGinsAT
has exact synonym: v-raf Murine Sarcoma Viral Oncogene Homolog B1 c.1799_1800TG>AT
in subset: NCIT C116977
in subset: NCIT C142799
in subset: NCIT C142800
in subset: NCIT C156952
in subset: NCIT C156953
in subset: NCIT C159415

BRAF NP_004324.2:p.V600E
type: NamedIndividual
type: Individuals
textual definition: A change in the amino acid residue at position 600 in the serine/threonine protein kinase B-raf protein where valine has been replaced by glutamic acid.
imported from: ncit.owl
code: C98342
Semantic_Type: Cell or Molecular Dysfunction
Display_Name: BRAF NP_004324.2:p.V600E
Preferred_Name: BRAF NP_004324.2:p.V600E
UMLS_CUI: C3273990
Contributing_Source: CTEP
Contributing_Source: CTRP
has exact synonym: Activating BRAF V600E Mutation
has exact synonym: BRAF NP_004324.2:p.V600E
has exact synonym: BRAF NP_004324.2:p.Val600Glu
has exact synonym: BRAF V600E
has exact synonym: BRAF V600E Activating Mutation
has exact synonym: BRAF V600E Mutation
has exact synonym: BRAF Val600Glu
has exact synonym: BRAF p.V600E
has exact synonym: BRAF p.Val600Glu
has exact synonym: NP_004324.2:p.V600E
has exact synonym: NP_004324.2:p.Val600Glu
has exact synonym: Serine/Threonine-Protein Kinase B-raf V600E
has exact synonym: Serine/Threonine-Protein Kinase B-raf Val600Glu
in subset: NCIT C116977
in subset: NCIT C118168
in subset: NCIT C142799
in subset: NCIT C142800

BRAF NM_004333.4:c.1799_1800delTGinsAA
type: NamedIndividual
type: Individuals
textual definition: A complex substitution where the nucleotide sequence at positions 1799 and 1780 of the coding sequence of the BRAF gene has changed from thymine-guanine to adenine-adenine.
imported from: ncit.owl
code: C98343
Semantic_Type: Cell or Molecular Dysfunction
Display_Name: BRAF NM_004333.4:c.1799_1800delTGinsAA
Preferred_Name: BRAF NM_004333.4:c.1799_1800delTGinsAA
UMLS_CUI: C3273991
Contributing_Source: CTRP
has exact synonym: B-RAF1 c.1799_1800TG>AA
has exact synonym: BRAF NM_004333.4:c.1799_1800delTGinsAA
has exact synonym: BRAF c.1799_1800TG>AA
has exact synonym: BRAF c.1799_1800delTGinsAA
has exact synonym: NM_004333.4:c.1799_1800TG>AA
has exact synonym: NM_004333.4:c.1799_1800delTGinsAA
has exact synonym: v-raf Murine Sarcoma Viral Oncogene Homolog B1 c.1799_1800TG>AA
in subset: NCIT C116977
in subset: NCIT C142799
in subset: NCIT C142800

BRAF NM_004333.4:c.1799T>A
type: NamedIndividual
type: Individuals
textual definition: A nucleotide substitution at position 1799 of the coding sequence of the BRAF gene where thymine has been mutated to adenine.
imported from: ncit.owl
code: C98344
Semantic_Type: Cell or Molecular Dysfunction
Display_Name: BRAF NM_004333.4:c.1799T>A
Preferred_Name: BRAF NM_004333.4:c.1799T>A
UMLS_CUI: C3273992
SNP_ID: rs113488022
Contributing_Source: CPTAC
Contributing_Source: CTRP
has exact synonym: B-RAF1 c.1799T>A
has exact synonym: BRAF NM_004333.4:c.1799T>A
has exact synonym: BRAF V600E (c.1799T>A) mutation
has exact synonym: BRAF c.1799T>A
has exact synonym: NM_004333.4:c.1799T>A
has exact synonym: v-raf Murine Sarcoma Viral Oncogene Homolog B1 c.1799T>A
in subset: NCIT C116977
in subset: NCIT C142799
in subset: NCIT C142800
in subset: NCIT C156952
in subset: NCIT C156953
in subset: NCIT C159414
in subset: NCIT C159415
in subset: NCIT C159417
in subset: NCIT C159420

BRAF NP_004324.2:p.V600G
type: NamedIndividual
type: Individuals
textual definition: A change in the amino acid residue at position 600 in the serine/threonine protein kinase B-raf protein where valine has been replaced by glycine.
imported from: ncit.owl
code: C98345
Semantic_Type: Cell or Molecular Dysfunction
Display_Name: BRAF NP_004324.2:p.V600G
Preferred_Name: BRAF NP_004324.2:p.V600G
UMLS_CUI: C3273993
Contributing_Source: CTRP
has exact synonym: BRAF NP_004324.2:p.V600G
has exact synonym: BRAF NP_004324.2:p.Val600Gly
has exact synonym: BRAF V600G
has exact synonym: BRAF p.V600G
has exact synonym: BRAF p.Val600Gly
has exact synonym: NP_004324.2:p.Val600Gly
has exact synonym: Serine/Threonine-Protein Kinase B-raf V600G
has exact synonym: Serine/Threonine-Protein Kinase B-raf Val600Gly
in subset: NCIT C116977
in subset: NCIT C142799
in subset: NCIT C142800

BRAF NM_004333.4:c.1799T>G
type: NamedIndividual
type: Individuals
textual definition: A nucleotide substitution at position 1799 of the coding sequence of the BRAF gene where thymine has been mutated to guanine.
imported from: ncit.owl
code: C98346
Semantic_Type: Cell or Molecular Dysfunction
Display_Name: BRAF NM_004333.4:c.1799T>G
Preferred_Name: BRAF NM_004333.4:c.1799T>G
UMLS_CUI: C3273994
Contributing_Source: CTRP
has exact synonym: B-RAF1 c.1799T>G
has exact synonym: BRAF NM_004333.4:c.1799T>G
has exact synonym: BRAF c.1799T>G
has exact synonym: NM_004333.4:c.1799T>G
has exact synonym: v-raf Murine Sarcoma Viral Oncogene Homolog B1 c.1799T>G
in subset: NCIT C116977
in subset: NCIT C142799
in subset: NCIT C142800

BRAF NP_004324.2:p.V600K
type: NamedIndividual
type: Individuals
textual definition: A change in the amino acid residue at position 600 in the serine/threonine protein kinase B-raf protein where valine has been replaced by lysine.
imported from: ncit.owl
code: C98347
Semantic_Type: Cell or Molecular Dysfunction
Display_Name: BRAF NP_004324.2:p.V600K
Preferred_Name: BRAF NP_004324.2:p.V600K
UMLS_CUI: C3273995
Contributing_Source: CTEP
Contributing_Source: CTRP
has exact synonym: BRAF NP_004324.2:p.V600K
has exact synonym: BRAF NP_004324.2:p.Val600Lys
has exact synonym: BRAF V600K
has exact synonym: BRAF Val600Lys
has exact synonym: BRAF p.V600K
has exact synonym: BRAF p.Val600Lys
has exact synonym: NP_004324.2:p.Val600Lys
has exact synonym: Serine/Threonine-Protein Kinase B-raf V600K
has exact synonym: Serine/Threonine-Protein Kinase B-raf Val600Lys
in subset: NCIT C116977
in subset: NCIT C142799
in subset: NCIT C142800

BRAF NM_004333.4:c.1798_1799delGTinsAA
type: NamedIndividual
type: Individuals
textual definition: A complex substitution where the nucleotide sequence at positions 1798 and 1799 of the coding sequence of the BRAF gene has changed from guanine-thymine to adenine-adenine.
imported from: ncit.owl
code: C98348
Semantic_Type: Cell or Molecular Dysfunction
Display_Name: BRAF NM_004333.4:c.1798_1799delGTinsAA
Preferred_Name: BRAF NM_004333.4:c.1798_1799delGTinsAA
UMLS_CUI: C3273996
Contributing_Source: CPTAC
Contributing_Source: CTRP
has exact synonym: B-RAF1 c.1798_1799GT>AA
has exact synonym: BRAF NM_004333.4:c.1798_1799delGTinsAA
has exact synonym: BRAF V600K (c.1798_1799GT>AA) mutation
has exact synonym: BRAF c.1798_1799GT>AA
has exact synonym: BRAF c.1798_1799delGTinsAA
has exact synonym: NM_004333.4:c.1798_1799GT>AA
has exact synonym: NM_004333.4:c.1798_1799delGTinsAA
has exact synonym: v-raf Murine Sarcoma Viral Oncogene Homolog B1 c.1798_1799GT>AA
in subset: NCIT C116977
in subset: NCIT C142799
in subset: NCIT C142800
in subset: NCIT C156952
in subset: NCIT C156953
in subset: NCIT C159415

BRAF NP_004324.2:p.V600L
type: NamedIndividual
type: Individuals
textual definition: A change in the amino acid residue at position 600 in the serine/threonine protein kinase B-raf protein where valine has been replaced by leucine.
imported from: ncit.owl
code: C98349
Semantic_Type: Cell or Molecular Dysfunction
Display_Name: BRAF NP_004324.2:p.V600L
Preferred_Name: BRAF NP_004324.2:p.V600L
UMLS_CUI: C3273997
Contributing_Source: CTRP
has exact synonym: BRAF NP_004324.2:p.V600L
has exact synonym: BRAF NP_004324.2:p.Val600Leu
has exact synonym: BRAF V600L
has exact synonym: BRAF p.V600L
has exact synonym: BRAF p.Val600Leu
has exact synonym: NP_004324.2:p.Val600Leu
has exact synonym: Serine/Threonine-Protein Kinase B-raf V600L
has exact synonym: Serine/Threonine-Protein Kinase B-raf Val600Leu
in subset: NCIT C116977
in subset: NCIT C142799
in subset: NCIT C142800

BRAF NM_004333.4:c.1798G>T
type: NamedIndividual
type: Individuals
textual definition: A nucleotide substitution at position 1798 of the coding sequence of the BRAF gene where guanine has been mutated to thymine.
imported from: ncit.owl
code: C98350
Semantic_Type: Cell or Molecular Dysfunction
Display_Name: BRAF NM_004333.4:c.1798G>T
Preferred_Name: BRAF NM_004333.4:c.1798G>T
UMLS_CUI: C3273998
SNP_ID: rs121913378
Contributing_Source: CTRP
has exact synonym: B-RAF1 c.1798G>T
has exact synonym: BRAF NM_004333.4:c.1798G>T
has exact synonym: BRAF c.1798G>T
has exact synonym: NM_004333.4:c.1798G>T
has exact synonym: v-raf Murine Sarcoma Viral Oncogene Homolog B1 c.1798G>T
in subset: NCIT C116977
in subset: NCIT C142799
in subset: NCIT C142800

BRAF NP_004324.2:p.V600M
type: NamedIndividual
type: Individuals
textual definition: A change in the amino acid residue at position 600 in the serine/threonine protein kinase B-raf protein where valine has been replaced by methionine.
imported from: ncit.owl
code: C98351
Semantic_Type: Cell or Molecular Dysfunction
Display_Name: BRAF NP_004324.2:p.V600M
Preferred_Name: BRAF NP_004324.2:p.V600M
UMLS_CUI: C3273999
Contributing_Source: CTRP
has exact synonym: BRAF NP_004324.2:p.V600M
has exact synonym: BRAF NP_004324.2:p.Val600Met
has exact synonym: BRAF V600M
has exact synonym: BRAF V600M Mutation
has exact synonym: BRAF Val600Met
has exact synonym: BRAF p.V600M
has exact synonym: BRAF p.Val600Met
has exact synonym: NP_004324.2:p.V600M
has exact synonym: NP_004324.2:p.Val600Met
has exact synonym: Serine/Threonine-Protein Kinase B-raf V600M
has exact synonym: Serine/Threonine-Protein Kinase B-raf Val600Met
in subset: NCIT C116977
in subset: NCIT C142799
in subset: NCIT C142800

BRAF NM_004333.4:c.1798G>A
type: NamedIndividual
type: Individuals
textual definition: A nucleotide substitution at position 1798 of the coding sequence of the BRAF gene where guanine has been mutated to adenine.
imported from: ncit.owl
code: C98352
Semantic_Type: Cell or Molecular Dysfunction
Display_Name: BRAF NM_004333.4:c.1798G>A
Preferred_Name: BRAF NM_004333.4:c.1798G>A
UMLS_CUI: C3274000
SNP_ID: rs121913378
Contributing_Source: CTRP
has exact synonym: B-RAF1 c.1798G>A
has exact synonym: BRAF NM_004333.4:c.1798G>A
has exact synonym: BRAF c.1798G>A
has exact synonym: NM_004333.4:c.1798G>A
has exact synonym: v-raf Murine Sarcoma Viral Oncogene Homolog B1 c.1798G>A
in subset: NCIT C116977
in subset: NCIT C142799
in subset: NCIT C142800

BRAF NP_004324.2:p.V600R
type: NamedIndividual
type: Individuals
textual definition: A change in the amino acid residue at position 600 in the serine/threonine protein kinase B-raf protein where valine has been replaced by arginine.
imported from: ncit.owl
code: C98353
Semantic_Type: Cell or Molecular Dysfunction
Display_Name: BRAF NP_004324.2:p.V600R
Preferred_Name: BRAF NP_004324.2:p.V600R
UMLS_CUI: C3274001
Contributing_Source: CTEP
Contributing_Source: CTRP
has exact synonym: BRAF NP_004324.2:p.V600R
has exact synonym: BRAF NP_004324.2:p.Val600Arg
has exact synonym: BRAF V600R
has exact synonym: BRAF Val600Arg
has exact synonym: BRAF p.V600R
has exact synonym: BRAF p.Val600Arg
has exact synonym: NP_004324.2:p.Val600Arg
has exact synonym: Serine/Threonine-Protein Kinase B-raf V600R
has exact synonym: Serine/Threonine-Protein Kinase B-raf Val600Arg
in subset: NCIT C116977
in subset: NCIT C142799
in subset: NCIT C142800

BRAF NM_004333.4:c.1798_1799delGTinsAG
type: NamedIndividual
type: Individuals
textual definition: A complex substitution where the nucleotide sequence at positions 1798 and 1799 of the coding sequence of the BRAF gene has changed from guanine-thymine to adenine-guanine.
imported from: ncit.owl
code: C98354
Semantic_Type: Cell or Molecular Dysfunction
Display_Name: BRAF NM_004333.4:c.1798_1799delGTinsAG
Preferred_Name: BRAF NM_004333.4:c.1798_1799delGTinsAG
UMLS_CUI: C3274002
Contributing_Source: CPTAC
Contributing_Source: CTRP
has exact synonym: B-RAF1 c.1798_1799GT>AG
has exact synonym: BRAF NM_004333.4:c.1798_1799delGTinsAG
has exact synonym: BRAF V600R (c.1798_1799GT>AG) mutation
has exact synonym: BRAF c.1798_1799GT>AG
has exact synonym: BRAF c.1798_1799delGTinsAG
has exact synonym: NM_004333.4:c.1798_1799GT>AG
has exact synonym: NM_004333.4:c.1798_1799delGTinsAG
has exact synonym: v-raf Murine Sarcoma Viral Oncogene Homolog B1 c.1798_1799GT>AG
in subset: NCIT C116977
in subset: NCIT C142799
in subset: NCIT C142800
in subset: NCIT C156952
in subset: NCIT C156953
in subset: NCIT C159415

BRAF NM_004333.4:c.1797_1799delAGTinsGAG
type: NamedIndividual
type: Individuals
textual definition: A complex substitution where the nucleotide sequence at positions 1797 through 1799 of the coding sequence of the BRAF gene has changed from adenine-guanine-thymine to guanine-adenine-guanine.
imported from: ncit.owl
code: C98355
Semantic_Type: Cell or Molecular Dysfunction
Display_Name: BRAF NM_004333.4:c.1797_1799delAGTinsGAG
Preferred_Name: BRAF NM_004333.4:c.1797_1799delAGTinsGAG
UMLS_CUI: C3274003
Contributing_Source: CTRP
has exact synonym: B-RAF1 c.1797_1799AGT>GAG
has exact synonym: BRAF NM_004333.4:c.1797_1799delAGTinsGAG
has exact synonym: BRAF c.1797_1799AGT>GAG
has exact synonym: BRAF c.1797_1799delAGTinsGAG
has exact synonym: NM_004333.4:c.1797_1799AGT>GAG
has exact synonym: NM_004333.4:c.1797_1799delAGTinsGAG
has exact synonym: v-raf Murine Sarcoma Viral Oncogene Homolog B1 c.1797_1799AGT>GAG
in subset: NCIT C116977
in subset: NCIT C142799
in subset: NCIT C142800