has_age
type: ObjectProperty
sub property of: has_organism_attribute
domain: Person
range: Class
  intersection of: Age
  intersection of: Restriction
    on property: has_unit
    some values from: year
  intersection of: Restriction
    on property: has_value
    some values from: integer
creator: Andre Dekker
definition: The object is the elapsed time since birth of the subject.

has_intent
type: ObjectProperty
sub property of: conceptually_related_to
domain: Health Care Activity
range: Intent
creator: Andre Dekker

has_heart_disorder
type: ObjectProperty
sub property of: has_disease
range: Heart Disorder
creator: Andre Dekker

has_neoplasm
type: ObjectProperty
sub property of: has_disease
range: Neoplastic Process
creator: Andre Dekker

has_age_at_pathology
type: ObjectProperty
sub property of: has_age
creator: Andre Dekker

has_age_at_diagnosis
type: ObjectProperty
sub property of: has_age
creator: Andre Dekker

has_age_at_start_rt
type: ObjectProperty
sub property of: has_age
creator: Andre Dekker

has_biological_sex
type: ObjectProperty
sub property of: has_organism_attribute
domain: Person
range: Sex
creator: Andre Dekker

brings_about
type: ObjectProperty
sub property of: functionally_related_to
inverse of: brought_about_by
creator: Andre Dekker
definition: Acts on or influences an entity.

has_disease
type: ObjectProperty
sub property of: has_occurrence
domain: Patient
range: Neoplastic Process
creator: Andre Dekker

has_histology
type: ObjectProperty
sub property of: has_finding
type: FunctionalProperty
type: InverseFunctionalProperty
domain: Neoplasm
range: Neoplasm by Morphology
creator: Andre Dekker

has_finding
type: ObjectProperty
sub property of: has_occurrence
range: Finding
creator: Andre Dekker

has_prescribed_radiation_dose
type: ObjectProperty
sub property of: has_dose
creator: Andre Dekker

has_procedure
type: ObjectProperty
sub property of: uses
domain: Patient
range: Intervention or Procedure
creator: Andre Dekker

has_stage
type: ObjectProperty
sub property of: has_finding
creator: Andre Dekker

has_survival
type: ObjectProperty
sub property of: has_finding
creator: Andre Dekker

has_unit
type: ObjectProperty
sub property of: has_property
creator: Andre Dekker

has_vital_status
type: ObjectProperty
sub property of: has_finding
creator: Andre Dekker

is_diagnosed_with
type: ObjectProperty
sub property of: diagnosed_by
creator: Andre Dekker

is_staged_with
type: ObjectProperty
sub property of: diagnosed_by
creator: Andre Dekker

temporally_related_to
type: ObjectProperty
sub property of: associated_with
creator: Andre Dekker
definition: Related in time by preceding, co-occuring with, or following.

follows
type: ObjectProperty
sub property of: temporally_related_to
inverse of: precedes
creator: Andre Dekker
definition: Occurs earlier in time. This includes antedates, comes before, is in advance of, predates, and is prior to.

is_adjuvant_to
type: ObjectProperty
sub property of: follows
creator: Andre Dekker

precedes
type: ObjectProperty
sub property of: temporally_related_to
creator: Andre Dekker

co-occurs_with
type: ObjectProperty
sub property of: temporally_related_to
creator: Andre Dekker
definition: Occurs at the same time as, together with, or jointly. This includes is co-incident with, is concurrent with, is contemporaneous with, accompanies, coexists with, and is concomitant with.

is_concurrent_with
type: ObjectProperty
sub property of: co-occurs_with
creator: Andre Dekker

is_neo_adjuvant_to
type: ObjectProperty
sub property of: precedes
creator: Andre Dekker

is_when
type: ObjectProperty
sub property of: co-occurs_with
creator: Andre Dekker

is_treated_in
type: ObjectProperty
sub property of: has_location
domain: Patient
range: Clinics and Hospitals
creator: Andre Dekker
definition: Hospital or institute (range) where patient (domain) was treated.

associated_with
type: ObjectProperty
type: TransitiveProperty
creator: Andre Dekker
definition: has a significant or salient relationship to.

has_person_identifier
type: ObjectProperty
sub property of: has_id
domain: Person
range: Person Identifier

conceptually_related_to
type: ObjectProperty
sub property of: associated_with
creator: Andre Dekker

delineation_of
type: ObjectProperty
sub property of: measurement_of
range: Anatomical Structure
creator: Andre Dekker

occurs_in
type: ObjectProperty
sub property of: functionally_related_to
inverse of: has_occurrence
creator: Andre Dekker
definition: Takes place in or happens under given conditions, circumstances, or time periods, or in a given location or population. This includes appears in, transpires, comes about, is present in, and exists in.

has_occurrence
type: ObjectProperty
sub property of: functionally_related_to
creator: Andre Dekker

functionally_related_to
type: ObjectProperty
sub property of: associated_with
creator: Andre Dekker
definition: That part of a phenomenon which is directly observable or concretely or visibly expressed, or which gives evidence to the underlying process. This includes expression of, display of, and exhibition of.

has_organism_attribute
type: ObjectProperty
sub property of: has_finding
creator: Andre Dekker

causes
type: ObjectProperty
sub property of: brings_about
inverse of: caused_by
creator: Andre Dekker

brought_about_by
type: ObjectProperty
sub property of: functionally_related_to
creator: Andre Dekker

caused_by
type: ObjectProperty
sub property of: brought_about_by
creator: Andre Dekker

spatially_related_to
type: ObjectProperty
sub property of: associated_with
creator: Andre Dekker

location_of
type: ObjectProperty
sub property of: spatially_related_to
inverse of: has_location
creator: Andre Dekker
definition: The position, site, or region of an entity or the site of a process.

has_location
type: ObjectProperty
sub property of: spatially_related_to
creator: Andre Dekker

indicates
type: ObjectProperty
sub property of: functionally_related_to
creator: Andre Dekker
definition: Gives evidence for the presence at some time of an entity or process.

indicated_by
type: ObjectProperty
sub property of: functionally_related_to
creator: Andre Dekker

uses
type: ObjectProperty
sub property of: functionally_related_to
inverse of: used_by
creator: Andre Dekker
definition: Employs in the carrying out of some activity. This includes applies, utilizes, employs, and avails.

used_by
type: ObjectProperty
sub property of: functionally_related_to
creator: Andre Dekker

diagnoses
type: ObjectProperty
sub property of: conceptually_related_to
inverse of: diagnosed_by
creator: Andre Dekker
definition: Distinguishes or identifies the nature or characteristics of.

diagnosed_by
type: ObjectProperty
sub property of: conceptually_related_to
creator: Andre Dekker

measures
type: ObjectProperty
sub property of: conceptually_related_to
inverse of: measured_by
creator: Andre Dekker
definition: Ascertains or marks the dimensions, quantity, degree, or capacity of.

measured_by
type: ObjectProperty
sub property of: conceptually_related_to
creator: Andre Dekker

property_of
type: ObjectProperty
sub property of: conceptually_related_to
inverse of: has_property
creator: Andre Dekker
definition: Characteristic of, or quality of.

has_property
type: ObjectProperty
sub property of: conceptually_related_to
creator: Andre Dekker

measurement_of
type: ObjectProperty
sub property of: conceptually_related_to
inverse of: has_measurement
creator: Andre Dekker
definition: The dimension, quantity, or capacity determined by measuring.

has_measurement
type: ObjectProperty
sub property of: conceptually_related_to
creator: Andre Dekker

degree_of
type: ObjectProperty
sub property of: conceptually_related_to
inverse of: has_degree
creator: Andre Dekker

has_degree
type: ObjectProperty
sub property of: conceptually_related_to
creator: Andre Dekker

uses_ACE_inhibitor
type: ObjectProperty
sub property of: uses
creator: Andre Dekker

has_performance_status
type: ObjectProperty
sub property of: has_finding
domain: Person
range: Performance Status
creator: Andre Dekker

has_AJCC_version
type: ObjectProperty
sub property of: has_version
domain: Cancer TNM Finding
range: AJCC Edition
creator: Andre Dekker

has_body_mass_index
type: ObjectProperty
sub property of: has_finding
creator: Andre Dekker

has_body_part
type: ObjectProperty
sub property of: has_part
creator: Andre Dekker

has_chemo_timing
type: ObjectProperty
sub property of: has_method
creator: Andre Dekker

has_count
type: ObjectProperty
sub property of: has_measurement
creator: Andre Dekker

has_fraction_count
type: ObjectProperty
sub property of: has_count
creator: Andre Dekker

has_image_count
type: ObjectProperty
sub property of: has_count
creator: Andre Dekker

has_patient_count
type: ObjectProperty
sub property of: has_count
creator: Andre Dekker

has_count_pet_5g
type: ObjectProperty
sub property of: has_count
creator: Andre Dekker

has_date
type: ObjectProperty
sub property of: co-occurs_with
creator: Andre Dekker

has_alive_last_checked_date
type: ObjectProperty
sub property of: has_date
creator: Andre Dekker

method_of
type: ObjectProperty
sub property of: conceptually_related_to
inverse of: has_method
creator: Andre Dekker
definition: The manner and sequence of events in performing an act or procedure.

has_method
type: ObjectProperty
sub property of: conceptually_related_to
creator: Andre Dekker

indicates
type: ObjectProperty
sub property of: conceptually_related_to
inverse of: indicated_by
creator: Andre Dekker

indicated_by
type: ObjectProperty
sub property of: conceptually_related_to
creator: Andre Dekker

physically_related_to
type: ObjectProperty
sub property of: associated_with
creator: Andre Dekker

part_of
type: ObjectProperty
sub property of: physically_related_to
inverse of: has_part
type: TransitiveProperty
creator: Andre Dekker
definition: Composes, with one or more other physical units, some larger whole. This includes component of, division of, portion of, fragment of, section of, and layer of.

has_part
type: ObjectProperty
sub property of: physically_related_to
creator: Andre Dekker

has_cause_of_death
type: ObjectProperty
sub property of: caused_by
creator: Andre Dekker

has_chemo_start_date
type: ObjectProperty
sub property of: has_date
creator: Andre Dekker

has_clinical_m_stage
type: ObjectProperty
sub property of: has_clinical_stage
creator: Andre Dekker

has_clinical_n_stage
type: ObjectProperty
sub property of: has_clinical_stage
creator: Andre Dekker

has_clinical_stage
type: ObjectProperty
sub property of: has_stage
creator: Andre Dekker

has_clinical_t_stage
type: ObjectProperty
sub property of: has_clinical_stage
creator: Andre Dekker

has_cumulative_dose
type: ObjectProperty
sub property of: has_dose
creator: Andre Dekker

has_body_height
type: ObjectProperty
sub property of: has_measurement
domain: Person
range: Stature
creator: Andre Dekker

has_body_weight
type: ObjectProperty
sub property of: has_measurement
domain: Person
range: Body Weight
creator: Andre Dekker

has_date_of_death
type: ObjectProperty
sub property of: has_date
creator: Andre Dekker

has_date_of_diagnosis
type: ObjectProperty
sub property of: has_date
creator: Andre Dekker

has_date_of_procedure
type: ObjectProperty
sub property of: has_date
creator: Andre Dekker

has_death
type: ObjectProperty
sub property of: has_vital_status
creator: Andre Dekker

has_death_finding
type: ObjectProperty
sub property of: has_finding
creator: Andre Dekker

has_comorbidity
type: ObjectProperty
sub property of: co-occurs_with
type: SymmetricProperty
domain: Disease or Disorder
range: Disease or Disorder
creator: Andre Dekker

has_disease_date
type: ObjectProperty
sub property of: has_date
creator: Andre Dekker

has_disease_finding
type: ObjectProperty
sub property of: has_finding
creator: Andre Dekker

has_disease_qualifier
type: ObjectProperty
sub property of: has_qualifier
creator: Andre Dekker

has_dose
type: ObjectProperty
sub property of: has_measurement
creator: Andre Dekker

has_duration
type: ObjectProperty
sub property of: has_measurement
creator: Andre Dekker

has_dysphagia
type: ObjectProperty
sub property of: has_finding
creator: Andre Dekker

has_dyspnea
type: ObjectProperty
sub property of: has_finding
creator: Andre Dekker

has_fev1_percentage
type: ObjectProperty
sub property of: has_measurement
creator: Andre Dekker

has_fev1_test
type: ObjectProperty
sub property of: has_procedure
creator: Andre Dekker

has_version
type: ObjectProperty
sub property of: has_method
range: Version
creator: Andre Dekker

has_fraction_dose
type: ObjectProperty
sub property of: has_dose
creator: Andre Dekker

has_fractionation_part
type: ObjectProperty
sub property of: has_part
creator: Andre Dekker

has_hypertension
type: ObjectProperty
sub property of: has_finding
creator: Andre Dekker

has_life
type: ObjectProperty
sub property of: has_vital_status
creator: Andre Dekker

has_marital_status
type: ObjectProperty
sub property of: has_finding
domain: Person
range: Marital Status
creator: Andre Dekker

has_max_esophagus_dose
type: ObjectProperty
sub property of: has_dose
creator: Andre Dekker

has_mean_esophagus_dose
type: ObjectProperty
sub property of: has_dose
creator: Andre Dekker

has_mean_lung_dose
type: ObjectProperty
sub property of: has_dose
creator: Andre Dekker

has_modality
type: ObjectProperty
sub property of: has_property
creator: Andre Dekker

has_nodal_tumor_volume
type: ObjectProperty
sub property of: has_tumor_volume
creator: Andre Dekker

has_overall_duration
type: ObjectProperty
sub property of: has_duration
creator: Andre Dekker

has_pacs_patient
type: ObjectProperty
sub property of: has_property
creator: Andre Dekker

has_pacs_series
type: ObjectProperty
sub property of: has_property
creator: Andre Dekker

has_pacs_study
type: ObjectProperty
sub property of: has_property
creator: Andre Dekker

has_pathological_m_stage
type: ObjectProperty
sub property of: has_pathological_stage
creator: Andre Dekker

has_pathological_n_stage
type: ObjectProperty
sub property of: has_pathological_stage
creator: Andre Dekker

has_pathological_stage
type: ObjectProperty
sub property of: has_stage
creator: Andre Dekker

has_pathological_t_stage
type: ObjectProperty
sub property of: has_pathological_stage
creator: Andre Dekker

has_patient_finding
type: ObjectProperty
sub property of: has_finding
creator: Andre Dekker

has_patient_guid
type: ObjectProperty
sub property of: has_person_identifier
sub property of: has_uid
domain: Patient
range: Patient GUID
creator: Andre Dekker

has_primary_tumor_volume
type: ObjectProperty
sub property of: has_tumor_volume
creator: Andre Dekker

has_procedure_date
type: ObjectProperty
sub property of: has_date
creator: Andre Dekker

has_procedure_duration
type: ObjectProperty
sub property of: has_duration
creator: Andre Dekker

has_qualifier
type: ObjectProperty
sub property of: has_property
creator: Andre Dekker

has_rt_dose
type: ObjectProperty
sub property of: has_dose
creator: Andre Dekker

has_rt_end_date
type: ObjectProperty
sub property of: has_date
creator: Andre Dekker

has_rt_start_date
type: ObjectProperty
sub property of: has_date
creator: Andre Dekker

has_radiation_therapy
type: ObjectProperty
sub property of: has_procedure
creator: Andre Dekker

has_secondary_neoplasm
type: ObjectProperty
sub property of: has_neoplasm
creator: Andre Dekker

has_series
type: ObjectProperty
sub property of: has_procedure
creator: Andre Dekker

has_series_guid
type: ObjectProperty
sub property of: has_uid
creator: Andre Dekker

has_series_uid
type: ObjectProperty
sub property of: has_uid
creator: Andre Dekker

has_smoking_status
type: ObjectProperty
sub property of: has_finding
creator: Andre Dekker

has_study
type: ObjectProperty
sub property of: has_procedure
creator: Andre Dekker

has_study_guid
type: ObjectProperty
sub property of: has_uid
creator: Andre Dekker

has_study_uid
type: ObjectProperty
sub property of: has_uid
creator: Andre Dekker

has_surgical_procedure
type: ObjectProperty
sub property of: has_procedure
creator: Andre Dekker

has_survival_time
type: ObjectProperty
sub property of: has_finding
creator: Andre Dekker

has_tumor_burden
type: ObjectProperty
sub property of: has_tumor_volume
creator: Andre Dekker

has_tumor_volume
type: ObjectProperty
sub property of: has_volume
creator: Andre Dekker

has_uid
type: ObjectProperty
sub property of: has_id
creator: Andre Dekker

has_volume
type: ObjectProperty
sub property of: has_measurement
creator: Andre Dekker

has_date_observed
type: ObjectProperty
sub property of: has_date
creator: Andre Dekker

has_id
type: ObjectProperty
sub property of: has_property
creator: Andre Dekker

has_birth
type: ObjectProperty
sub property of: has_organism_attribute
domain: Person
range: Birth
creator: Andre Dekker

has_recurrence_status
type: ObjectProperty
sub property of: has_finding
creator: Johan van Soest

has_recurrence_time
type: ObjectProperty
sub property of: has_finding
creator: Johan van Soest

has_chemo_end_date
type: ObjectProperty
sub property of: has_date
creator: Andre Dekker

has_laterality
type: ObjectProperty
sub property of: has_location
range: Laterality
creator: Andre Dekker

process_of
type: ObjectProperty
sub property of: occurs_in
inverse of: has_process
creator: Andre Dekker
definition: Action, function, or state of.

has_process
type: ObjectProperty
sub property of: has_occurrence
creator: Andre Dekker

manifestation_of
type: ObjectProperty
sub property of: functionally_related_to
inverse of: has_manifestation
creator: Andre Dekker

has_overall_stage
type: ObjectProperty
sub property of: has_stage
creator: Andre Dekker

has_manifestation
type: ObjectProperty
sub property of: functionally_related_to
creator: Andre Dekker

result_of
type: ObjectProperty
sub property of: functionally_related_to
inverse of: has_result
creator: Andre Dekker
definition: The condition, product, or state occurring as a consequence, effect, or conclusion of an activity or process. This includes product of, effect of, sequel of, outcome of, culmination of, and completion of.

has_result
type: ObjectProperty
sub property of: functionally_related_to
creator: Andre Dekker

affects
type: ObjectProperty
sub property of: functionally_related_to
creator: Andre Dekker
definition: Produces a direct effect on. Implied here is the altering or influencing of an existing condition, state, situation, or entity. This includes has a role in, alters, influences, predisposes, catalyzes, stimulates, regulates, depresses, impedes, enhances, contributes to, leads to, and modifies.

affected_by
type: ObjectProperty
sub property of: functionally_related_to
inverse of: disrupts
creator: Andre Dekker

manages
type: ObjectProperty
sub property of: affects
inverse of: managed_by
creator: Andre Dekker
definition: Administers, or contributes to the care of an individual or group of individuals.

managed_by
type: ObjectProperty
sub property of: affected_by
creator: Andre Dekker

treats
type: ObjectProperty
sub property of: affects
inverse of: treated_by
creator: Andre Dekker
definition: Applies a remedy with the object of effecting a cure or managing a condition.

treated_by
type: ObjectProperty
sub property of: affected_by
creator: Andre Dekker

complicates
type: ObjectProperty
sub property of: affects
inverse of: complicated_by
creator: Andre Dekker
definition: Causes to become more severe or complex or results in adverse effects.

complicated_by
type: ObjectProperty
sub property of: affected_by
creator: Andre Dekker

prevents
type: ObjectProperty
sub property of: affects
inverse of: prevented_by
creator: Andre Dekker
definition: Stops, hinders or eliminates an action or condition.

prevented_by
type: ObjectProperty
sub property of: affected_by
creator: Andre Dekker

disrupts
type: ObjectProperty
sub property of: affects
creator: Andre Dekker
definition: Alters or influences an already existing condition, state, or situation. Produces a negative effect on.

disrupted_by
type: ObjectProperty
sub property of: affected_by
creator: Andre Dekker

performs
type: ObjectProperty
sub property of: functionally_related_to
inverse of: performed_by
creator: Andre Dekker
definition: Executes, accomplishes, or achieves an activity.

performed_by
type: ObjectProperty
sub property of: functionally_related_to
creator: Andre Dekker

exhibits
type: ObjectProperty
sub property of: performs
inverse of: exhibited_by
creator: Andre Dekker
definition: Shows or demonstrates.

exhibited_by
type: ObjectProperty
sub property of: performed_by
creator: Andre Dekker

produces
type: ObjectProperty
sub property of: brings_about
inverse of: produced_by
creator: Andre Dekker
definition: Brings forth, generates or creates. This includes yields, secretes, emits, biosynthesizes, generates, releases, discharges, and creates.

produced_by
type: ObjectProperty
sub property of: brought_about_by
creator: Andre Dekker

practices
type: ObjectProperty
sub property of: performs
inverse of: practiced_by
creator: Andre Dekker
definition: Performs habitually or customarily.

practiced_by
type: ObjectProperty
sub property of: performed_by
creator: Andre Dekker

interacts_with
type: ObjectProperty
sub property of: affects
sub property of: affected_by
creator: Andre Dekker

carries_out
type: ObjectProperty
sub property of: performs
inverse of: carried_out_by
creator: Andre Dekker
definition: Executes a function or performs a procedure or activity. This includes transacts, operates on, handles, and executes.

carried_out_by
type: ObjectProperty
sub property of: performed_by
creator: Andre Dekker

contains
type: ObjectProperty
sub property of: physically_related_to
creator: Andre Dekker
definition: Holds or is the receptacle for fluids or other substances. This includes is filled with, holds, and is occupied by.

contained_in
type: ObjectProperty
sub property of: physically_related_to
creator: Andre Dekker

consists_of
type: ObjectProperty
sub property of: physically_related_to
inverse of: constitutes
creator: Andre Dekker
definition: Is structurally made up of in whole or in part of some material or matter. This includes composed of, made of, and formed of.

connected_to
type: ObjectProperty
sub property of: physically_related_to
creator: Andre Dekker
definition: Directly attached to another physical unit as tendons are connected to muscles. This includes attached to and anchored to.

interconnects
type: ObjectProperty
sub property of: physically_related_to
inverse of: interconnected_by
creator: Andre Dekker
definition: Serves to link or join together two or more other physical units. This includes joins, links, conjoins, articulates, separates, and bridges.

branch_of
type: ObjectProperty
sub property of: physically_related_to
creator: Andre Dekker
definition: Arises from the division of. For example, the arborization of arteries.

tributary_of
type: ObjectProperty
sub property of: physically_related_to
inverse of: has_tributary
creator: Andre Dekker
definition: Merges with. For example, the confluence of veins.

ingredient_of
type: ObjectProperty
sub property of: physically_related_to
inverse of: has_ingredient
creator: Andre Dekker
definition: Is a component of, as in a constituent of a preparation.

has_ingredient
type: ObjectProperty
sub property of: physically_related_to
creator: Andre Dekker

has_tributary
type: ObjectProperty
sub property of: physically_related_to
creator: Andre Dekker

interconnected_by
type: ObjectProperty
sub property of: physically_related_to
creator: Andre Dekker

constitutes
type: ObjectProperty
sub property of: physically_related_to
creator: Andre Dekker

has_branch
type: ObjectProperty
sub property of: physically_related_to
creator: Andre Dekker

adjacent_to
type: ObjectProperty
sub property of: spatially_related_to
creator: Andre Dekker
definition: Close to, near or abutting another physical unit with no other structure of the same kind intervening. This includes adjoins, abuts, is contiguous to, is juxtaposed, and is close to.

surrounds
type: ObjectProperty
sub property of: spatially_related_to
inverse of: surrounded_by
creator: Andre Dekker
definition: Establishes the boundaries for, or defines the limits of another physical structure. This includes limits, bounds, confines, encloses, and circumscribes.

surrounded_by
type: ObjectProperty
sub property of: spatially_related_to
creator: Andre Dekker

traverses
type: ObjectProperty
sub property of: spatially_related_to
inverse of: traversed_by
creator: Andre Dekker
definition: Crosses or extends across another physical structure or area. This includes crosses over and crosses through.

traversed_by
type: ObjectProperty
sub property of: spatially_related_to
creator: Andre Dekker

conceptual_part_of
type: ObjectProperty
sub property of: conceptually_related_to
inverse of: has_conceptual_part
creator: Andre Dekker
definition: Conceptually a portion, division, or component of some larger whole.

has_conceptual_part
type: ObjectProperty
sub property of: conceptually_related_to
creator: Andre Dekker

evaluation_of
type: ObjectProperty
sub property of: conceptually_related_to
inverse of: has_evaluation
creator: Andre Dekker
definition: Judgment of the value or degree of some attribute or process.

has_evaluation
type: ObjectProperty
sub property of: conceptually_related_to
creator: Andre Dekker

assesses_effect_of
type: ObjectProperty
sub property of: analyzes
inverse of: assessed_for_effect_by
creator: Andre Dekker
definition: Analyzes the influence or consequences of the function or action of.

assessed_for_effect_by
type: ObjectProperty
sub property of: analyzed_by
creator: Andre Dekker

issue_in
type: ObjectProperty
sub property of: conceptually_related_to
inverse of: has_issue
creator: Andre Dekker
definition: Is an issue in or a point of discussion, study, debate, or dispute.

has_issue
type: ObjectProperty
sub property of: conceptually_related_to
creator: Andre Dekker

derivative_of
type: ObjectProperty
sub property of: conceptually_related_to
inverse of: has_derivative
creator: Andre Dekker
definition: In chemistry, a substance structurally related to another or that can be made from the other substance. This is used only for structural relationships. This does not include functional relationships such as metabolite of, by product of, nor analog of.

has_derivative
type: ObjectProperty
sub property of: conceptually_related_to
creator: Andre Dekker

developmental_form_of
type: ObjectProperty
sub property of: conceptually_related_to
inverse of: has_developmental_form
creator: Andre Dekker
definition: An earlier stage in the individual maturation of.

has_developmental_form
type: ObjectProperty
sub property of: conceptually_related_to
creator: Andre Dekker

analyzes
type: ObjectProperty
sub property of: conceptually_related_to
inverse of: analyzed_by
creator: Andre Dekker
definition: Studies or examines using established quantitative or qualitative methods.

analyzed_by
type: ObjectProperty
sub property of: conceptually_related_to
creator: Andre Dekker

at_date_time
type: DatatypeProperty
range: dateTime
creator: Andre Dekker

has_value
type: DatatypeProperty
creator: Andre Dekker

Palliative
type: Class
subclass of: Intent
definition: Any action or response, without curative intent, that mitigates some or all of the unpleasant effects of a disease or condition.

Adjuvant Radiotherapy
type: Class
subclass of: Radiation Therapy
subclass of: Adjuvant Therapy
definition: Radiation therapy that is administered to augment or stimulate other treatment modalities or to minimize or prevent disease recurrence.

Great Blood Vessel
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Any of the major arteries or veins attached to the cardiac atria or ventricles. This includes the aorta, superior and inferior vena cava and the pulmonary arteries and veins.

Narrow Surgical Margin
type: Class
subclass of: Surgical Margin
definition: An indication that a surgical margin is in close proximity to the excised tumor.

Volume Modulated Arc Therapy
type: Class
subclass of: Radiation Therapy
definition: Radiation therapy delivered to the whole volume of target tissue by a single rotation of the linear accelerator gantry.

Scanning Proton Beam Therapy
type: Class
subclass of: Proton Beam Radiation Therapy
definition: Proton beam radiation therapy in which magnets deflect and steer the proton beam.

Scattering Proton Beam Therapy
type: Class
subclass of: Proton Beam Radiation Therapy
definition: Proton beam radiation therapy in which the proton beam is spread by placing scattering material in the path of the protons.

ECOG Performance Status
type: Class
equivalent class: Zubrod Performance Status
subclass of: Performance Status
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A performance status scale designed to assess disease progression and its affect on the daily living abilities of the patient.

ECOG Performance Status 0
type: Class
subclass of: ECOG Performance Status
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Fully active, able to carry on all pre-disease performance without restriction.

ECOG Performance Status 1
type: Class
subclass of: ECOG Performance Status
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature, e.g., light house work, office work.

ECOG Performance Status 2
type: Class
subclass of: ECOG Performance Status
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Ambulatory and capable of all self care but unable to carry out any work activities. Up and about more than 50% of waking hours.

ECOG Performance Status 3
type: Class
subclass of: ECOG Performance Status
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Capable of only limited selfcare, confined to bed or chair more than 50% of waking hours.

ECOG Performance Status 4
type: Class
subclass of: ECOG Performance Status
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Completely disabled. Cannot carry on any selfcare. Totally confined to bed or chair.

ECOG Performance Status 5
type: Class
subclass of: ECOG Performance Status
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Dead.

Tumor Regression Grade
type: Class
subclass of: Classification
alternative label: TRG
definition: A pathologic grading system used to evaluate the tumor response to preoperative chemotherapy and radiation.

FOLFOX Regimen
type: Class
subclass of: Chemotherapy Regimen Used to Treat Colorectal Carcinoma
subclass of: Restriction
  on property: uses
  some values from: Oxaliplatin
subclass of: Restriction
  on property: uses
  some values from: Fluorouracil
subclass of: Restriction
  on property: uses
  some values from: Leucovorin Calcium
alternative label: CF/5-FU/L-OHP
alternative label: Fluorouracil/Leucovorin Calcium/Oxaliplatin
definition: One of several chemotherapy regimens that include leucovorin calcium (calcium folinate), 5-fluorouracil and oxaliplatin and which may be used in the treatment of advanced-stage and metastatic colorectal cancer. FOLFOX regimens differ in agent dosing and administration schedule and include FOLFOX 4, FOLFOX 6, modified FOLFOX 6 (mFOLFOX 6) and FOLFOX 7.

Percent Predicted Forced Expiratory Volume in 1 Second
type: Class
subclass of: Percentage
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Forced expiratory volume in one second as a proportion of the predicted normal value. (CDISC)

Dose Volume Histogram
type: Class
subclass of: Intellectual Product
definition: A plot of a cumulative dose-volume frequency distribution that graphically summarizes the simulated radiation distribution within a volume of interest of a patient which would result from a proposed radiation treatment plan.

Gross Target Volume
type: Class
equivalent class: Gross Tumor Volume
subclass of: Target Volume
definition: The gross palpable or visible/demonstrable extent and location of malignant growth.

Low Anterior Resection
type: Class
subclass of: Anterior resection of rectum
definition: Resection of the rectum for cancer through an incision in the lower abdomen.

Grade X
type: Class
subclass of: Disease Grade Qualifier
alternative label: GX
definition: A morphologic qualifier indicating that the grade of a neoplasm cannot be assessed.

4-Dimensional Conformal Radiation Therapy
type: Class
subclass of: Radiation Therapy
subclass of: Motion Management Procedure
definition: 3-Dimensional conformal radiation therapy that is designed to compensate for motion of the tumor and surrounding normal tissue during each treatment session.

4-Dimensional Computed Tomography
type: Class
subclass of: Computed Tomography
subclass of: Motion Management Procedure
alternative label: 4DCT
alternative label: RC-CT
alternative label: Respiratory Correlated CT
definition: Computed tomography scans designed to minimize motion artifacts. 4DCT can be accomplished by collecting data for the duration of the patient's respiratory cycle and by oversampling CT data acquisition at each slice.

Robot-Assisted Laparoscopic Surgery
type: Class
subclass of: Laparoscopic Surgery
subclass of: Intervention or Procedure
definition: A surgical technique that uses a specially designed robotic system to aid with a laparoscopic surgical procedure.

Oxaliplatin
type: Class
subclass of: Pharmacologic Substance

Stereotactic Body Radiation Therapy
type: Class
subclass of: Radiation Therapy
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: SBRT
definition: Stereotactic radiation therapy in which one or several maximum dose radiation treatments are delivered targeting cancers of the body, excluding the brain or spine.

Macroscopically Positive Surgical Margin
type: Class
subclass of: Positive Surgical Margin
definition: The presence of macroscopically visible residual tumor at the edge of a surgically excised specimen.

Grossly Negative and Microscopically Positive Surgical Margin
type: Class
subclass of: Positive Surgical Margin
definition: The presence of microscopically visible residual tumor at the edge of a surgically excised specimen that otherwise looks macroscopically normal.

Tumor Size
type: Class
subclass of: Size
definition: The size of a tumor in its greatest dimension.

Chemotherapy Regimen or Agent Combination
type: Class
subclass of: Treatment Regimen
definition: A combination of multiple drugs used in standard or clinical trial treatments. The order, dosage or dosing interval of the individual ingredients may not be specified.

Upper Third of the Esophagus
type: Class
subclass of: Segment of esophagus
alternative label: Upper Esophagus
definition: The upper one third of esophagus in which the muscle layer is composed of muscle cells of the striated type.

Middle Third of the Esophagus
type: Class
subclass of: Segment of esophagus
alternative label: Middle Esophagus
definition: The middle one third of the esophagus in which the muscle layer is composed of muscle cells of the striated and smooth types.

Lower Third of the Esophagus
type: Class
subclass of: Segment of esophagus
alternative label: Lower Esophagus
definition: The lower one third of the esophagus in which the muscle layer is composed of muscle cells predominantly of the smooth type.

Pathologic Complete Response
type: Class
subclass of: Disease Response
alternative label: Complete Pathological Response
alternative label: pCR
definition: The disappearance of all signs of cancer, supported by pathological examination.

Supratentorial Brain
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: The part of the brain above the tentorium cerebellum. (NCI) For most authors, this is the cerebral hemispheres plus the basal ganglia, but most clinicians do not include the basal ganglia.

4D PET Scan
type: Class
subclass of: Positron Emission Tomography
subclass of: Motion Management Procedure
alternative label: 4D Gated PET Scan
definition: Positron emission tomography imaging collected over time. It is designed to capture the internal movement of organs and the metabolism of the tumor. It creates the most complete and accurate information on the tumor and provides information how the tumor moves with breathing and other body motions.

Vinorelbine
type: Class
subclass of: Pharmacologic Substance
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase. This agent may also interfere with amino acid, cyclic AMP. and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis.

Carboplatin
type: Class
subclass of: Platinum Compound
subclass of: Pharmacologic Substance
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A second-generation platinum compound with a broad spectrum of antineoplastic properties. Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl residue. This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, thereby inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These carboplatin-induced DNA and protein effects result in apoptosis and cell growth inhibition. This agent possesses tumoricidal activity similar to that of its parent compound, cisplatin, but is more stable and less toxic. (NCI04)

Epipodophyllotoxin Compound
type: Class
subclass of: Chemical Viewed Structurally
definition: An alkaloid isolated or derived synthetically from Podophyllum peltatum that can bind to and inhibit topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death.

Stoma
type: Class
subclass of: Acquired Abnormality
definition: A surgically created opening from an area inside the body to the outside.

Stage IA3
type: Class
subclass of: Stage IA
definition: A stage term referring to invasive lung cancer. It includes: T1c, N0, M0. T1c: Tumor measuring more than 2 cm but 3 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (adapted from AJCC)

Paclitaxel
type: Class
subclass of: Taxane Compound
subclass of: Pharmacologic Substance
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A compound extracted from the Pacific yew tree Taxus brevifolia with antineoplastic activity. Paclitaxel binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. This agent also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). (NCI04)

Occult Stage
type: Class
subclass of: Disease Stage Qualifier
definition: A stage term that refers to a cancer in which the primary site is unknown (not detectable by clinical or radiologic examination). The definition of occult stage depends on the particular type of cancer that it refers to; for example, for breast cancer, occult stage is defined as cancer presenting with axillary lymph node metastasis without a primary in the breast being found; for non-small cell lung carcinoma, occult stage is defined as cancer detectable by sputum cytology only and the primary tumor is undetectable radiographically or during bronchoscopy.

Unresectable
type: Class
subclass of: Disease Treatment Qualifier
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Unable to be removed with surgery.

Moderately Differentiated
type: Class
subclass of: Histologic Grade
definition: Describes tumor cells that have lost some of the appearance of normal cells. They tend to grow and spread at a faster rate than well differentiated tumor cells.

Poorly Differentiated
type: Class
subclass of: Histologic Grade
definition: Describes tumor cells that generally have lost most of the appearance of normal cells. They tend to grow and spread.

Well Differentiated
type: Class
subclass of: Histologic Grade
definition: Describes tumor cells that generally retain the appearance of normal cells and tend to grow and spread at a slower rate than undifferentiated or poorly differentiated tumor cells.

Woman
type: Class
equivalent class: Class
  intersection of: Person
  intersection of: Restriction
    on property: has_biological_sex
    some values from: Female
definition: An adult, female human.

Man
type: Class
equivalent class: Class
  intersection of: Person
  intersection of: Restriction
    on property: has_biological_sex
    some values from: Male
definition: An adult, male human.

Platinum Compound
type: Class
subclass of: Chemical Viewed Structurally
definition: A chemotherapy compound that contains a platinum atom. Platinum compounds do not contain alkyl groups but do cause DNA crosslinks and adducts similar to alkylating agents. DNA crosslinks and adducts ultimately lead to the induction of apoptosis.

Taxane Compound
type: Class
subclass of: Chemical Viewed Structurally
definition: A type of drug that blocks cell growth by stopping mitosis (cell division). Taxanes interfere with microtubules (cellular structures that help move chromosomes during mitosis). They are used to treat cancer. A taxane is a type of mitotic inhibitor and a type of antimicrotubule agent.

Biopsy
type: Class
subclass of: Diagnostic Procedure
definition: The removal of tissue specimens or fluid from the living body for microscopic examination, performed to establish a diagnosis.

Multimodality Therapy
type: Class
subclass of: Therapeutic or Preventive Procedure
disjoint with: Unimodality Therapy
definition: Use of two or more simultaneous or consecutive treatment modalities; e.g., surgery + radiation, or radiation + immunotherapy. Does not refer to use of two or more chemotherapeutic agents.

Docetaxel
type: Class
subclass of: Taxane Compound
subclass of: Pharmacologic Substance
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A semi-synthetic, second-generation taxane derived from a compound found in the European yew tree, Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent. (NCI04)

Laparotomy
type: Class
subclass of: Surgical Procedure
subclass of: Intervention or Procedure
definition: Creation of a surgical opening into the abdominal cavity.

Lymphadenectomy
type: Class
subclass of: Surgical Procedure
alternative label: Lymph Node Dissection
definition: Surgical removal of lymph nodes, usually done to assess the spread of cancer.

Pneumonectomy
type: Class
subclass of: Thoracic Surgical Procedure
see also: EuroCAT Umbrella Protocol for NSCLC
definition: The excision of part or all of a lung.

Radiation Therapy
type: Class
subclass of: Therapeutic Procedure
definition: Treatment of a disease by means of exposure of the target or the whole body to radiation. Radiation therapy is often used as part of curative therapy and occasionally as a component of palliative treatment for cancer. Other uses include total body irradiation prior to transplantation.

Surgical Procedure
type: Class
subclass of: Intervention or Procedure
subclass of: Therapeutic or Preventive Procedure
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A diagnostic or treatment procedure performed by manual and/or instrumental means, often involving an incision and the removal or replacement of a diseased organ or tissue; of or relating to or involving or used in surgery or requiring or amenable to treatment by surgery.

Stereotactic Radiosurgery
type: Class
subclass of: Radiation Therapy
definition: A non-surgical procedure that was developed to deliver one or several maximum dose targeted radiation treatments for cancers in the brain or spine.

Adjuvant Chemotherapy
type: Class
subclass of: Chemotherapy
subclass of: Adjuvant Therapy
definition: Chemotherapy that is administered subsequent to the main treatment plan to minimize or prevent disease recurrence.

Gamma Knife
type: Class
subclass of: Radiation Therapy
definition: A treatment using gamma rays, a type of high-energy radiation that can be tightly focused on small tumors or other lesions in the head or neck, so very little normal tissue receives radiation. The gamma rays are aimed at the tumor from many different angles at once, and deliver a large dose of radiation exactly to the tumor in one treatment session. This procedure is a type of stereotactic radiosurgery.

Chemotherapy
type: Class
subclass of: Therapeutic Procedure
see also: EuroCAT Umbrella Protocol for NSCLC
definition: The use of synthetic or naturally-occurring chemicals for the treatment of diseases.

Fractionation
type: Class
subclass of: Therapeutic or Preventive Procedure
definition: Dividing the total dose of radiation therapy into several smaller, equal doses delivered over a period of several days.

Thoracic Surgical Procedure
type: Class
subclass of: Surgical Procedure
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Surgery performed on the thoracic organs, most commonly the lungs and the heart.

Neoadjuvant Therapy
type: Class
subclass of: Therapeutic or Preventive Procedure
definition: Treatment given as a first step to shrink a tumor before the main treatment, which is usually surgery, is given. Examples of neoadjuvant therapy include chemotherapy, radiation therapy, and hormone therapy. It is a type of induction therapy.

Adjuvant Therapy
type: Class
subclass of: Therapeutic or Preventive Procedure
definition: Any therapy that is administered to augment or stimulate other treatment modalities or to minimize or prevent disease recurrence subsequent to the main treatment plan.

Maintenance Therapy
type: Class
subclass of: Therapeutic or Preventive Procedure
definition: Continuation of treatment for an extended period of time to prevent relapse.

Treatment Regimen
type: Class
subclass of: Therapeutic Procedure
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: Treatment Protocol
definition: A treatment plan that specifies the dosage, the schedule, and the duration of treatment.

Laparoscopic Surgery
type: Class
subclass of: Surgical Procedure
subclass of: Intervention or Procedure
definition: Surgery done with the aid of a laparoscope. A laparoscope is a thin, tube-like instrument with a light and a lens for viewing. It may also have a tool to remove tissue to be checked under a microscope for signs of disease.

Follow-up
type: Class
subclass of: Health Care Activity
see also: EuroCAT Umbrella Protocol for NSCLC
definition: The activity of monitoring a person's health over time after treatment.

3-Dimensional Conformal Radiation Therapy
type: Class
subclass of: Radiation Therapy
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: 3D-CRT
definition: A process by which a dose of radiation is automatically shaped to closely conform to the entire volume of the tumor, so that surrounding normal tissue is spared and treatment toxicity is decreased.

Abdominal Surgical Procedure
type: Class
subclass of: Surgical Procedure
definition: Surgery performed on any part of the abdominal region of the body.

Intensity-Modulated Radiation Therapy
type: Class
subclass of: Radiation Therapy
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: IMRT
definition: An advanced form of 3-Dimensional Conformal Radiation Therapy (3D CRT) that involves the use of varying intensities of small radiation beams to produce dosage distributions that are more precise than those possible with 3D CRT.

Total Mesorectal Excision
type: Class
subclass of: Abdominal Surgical Procedure
subclass of: Therapeutic Surgical Procedure
alternative label: TME
definition: Surgery for rectal cancer involving precise removal of an intact mesorectal envelope with tumor-free margins. Associated with local recurrence rates below 5% in clinical trials.

Body Mass Index
type: Class
subclass of: Clinical Attribute
definition: A general indicator of the body fat an individual is carrying based upon the ratio of weight to height.

Comorbidity
type: Class
subclass of: Disease or Disorder
subclass of: Disease or Syndrome
see also: EuroCAT Umbrella Protocol for NSCLC
definition: The coexistence of two or more disease processes.

Data Source
type: Class
subclass of: Qualitative Concept
definition: The person or authoritative body who provided the information.

Female
type: Class
subclass of: Sex
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A person who belongs to the sex that normally produces ova. The term is used to indicate biological sex distinctions, or cultural gender role distinctions, or both.

Magnetic Resonance Imaging
type: Class
subclass of: Diagnostic Procedure
definition: Imaging that uses radiofrequency waves and a strong magnetic field rather than x-rays to provide amazingly clear and detailed pictures of internal organs and tissues. The technique is valuable for the diagnosis of many pathologic conditions, including cancer, heart and vascular disease, stroke, and joint and musculoskeletal disorders.

Patient
type: Class
subclass of: Person
definition: A person who receives medical attention, care, or treatment, or who is registered with medical professional or institution with the purpose to receive medical care when necessary.

Positron Emission Tomography
type: Class
subclass of: Diagnostic Procedure
alternative label: PET Scan
definition: A technique for measuring the gamma radiation produced by collisions of electrons and positrons (anti-electrons) within living tissue. In positron emission tomography (PET), a subject is given a dose of a positron-emitting radionuclide attached to a metabolically active substance (for example, 2-fluoro-2-deoxy-D-glucose (FDG), which is similar to a naturally occurring sugar, glucose, with the addition of a radioactive fluorine atom). When living tissue containing the positron emitter is bombarded by electrons, gamma radiation produced by collisions of electrons and positrons is detected by a scanner, revealing in fine detail the tissue location of the metabolically-active substance administered.

Computed Tomography
type: Class
subclass of: Diagnostic Procedure
definition: A method of examining structures within the body by scanning them with X rays and using a computer to construct a series of cross-sectional scans along a single axis.

Cetuximab
type: Class
subclass of: Pharmacologic Substance
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A recombinant, chimeric monoclonal antibody directed against the epidermal growth factor (EGFR) with antineoplastic activity. Cetuximab binds to the extracellular domain of the EGFR, thereby preventing the activation and subsequent dimerization of the receptor; the decrease in receptor activation and dimerization may result in an inhibition in signal transduction and anti-proliferative effects. This agent may inhibit EGFR-dependent primary tumor growth and metastasis. EGFR is overexpressed on the cell surfaces of various solid tumors.

Gender
type: Class
subclass of: Organism Attribute
definition: The assemblage of properties that distinguish people on the basis of the societal roles expected for the two sexes.

Smoking Cessation
type: Class
subclass of: Individual Behavior
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: nicotine_stop
definition: Discontinuation of the habit of smoking.

Blood Sample
type: Class
subclass of: Biospecimen
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A small volume of blood removed for testing or storage.

Capecitabine
type: Class
subclass of: Pharmacologic Substance
alternative label: Xeloda

Histologic Grade
type: Class
subclass of: Disease Grade Qualifier
subclass of: Qualitative Concept
definition: The degree of abnormality of cancer cells, a measure of differentiation, the extent to which cancer cells are similar in appearance and function to healthy cells of the same tissue type. The degree of differentiation often relates to the clinical behavior of the particular tumor. Based on the microscopic findings, tumor grade is commonly described by one of four degrees of severity. Histopathologic grade of a tumor may be used to plan treatment and estimate the future course, outcome, and overall prognosis of disease. Certain types of cancers, such as soft tissue sarcoma, primary brain tumors, lymphomas, and breast have special grading systems.

Tumor Tissue
type: Class
subclass of: Tissue Sample
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A tumor sample, or entire tumor that is removed for microscopic examination.

Diagnostic Procedure
type: Class
equivalent class: Diagnostic Procedure
subclass of: Intervention or Procedure
definition: Any procedure or test to diagnose a disease or disorder.

Raltitrexed
type: Class
subclass of: Pharmacologic Substance
alternative label: Tomudex
definition: An anticancer drug that stops tumor cells from growing by blocking the ability of cells to make DNA. It belongs to the family of drugs called thymidylate synthase inhibitors.

Mitomycin
type: Class
subclass of: Antibiotic
alternative label: Mitomycin-C
definition: A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations.

Clinics and Hospitals
type: Class
subclass of: Health Care Related Organization
disjoint with: Person
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: Institute
definition: Institutions with an organized medical staff for the medical care, treatment, and cure of the sick and wounded, for the study of disease, and for the training of physicians, nurses, and allied health personnel.

Tissue Sample
type: Class
subclass of: Biospecimen
definition: A piece of tissue removed from an organism for examination, analysis, or propagation.

Smoking Status
type: Class
subclass of: Clinical Attribute
see also: EuroCAT Umbrella Protocol for NSCLC
definition: An indication of a person's current tobacco and nicotine consumption as well as some indication of smoking history.

Social Circumstances
type: Class
subclass of: Conceptual Entity
definition: A set of concepts that results from or is influenced by criteria or activities associated with the social environment of a person.

Male
type: Class
subclass of: Sex
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A person who belongs to the sex that normally produces sperm. The term is used to indicate biological sex distinctions, cultural gender role distinctions, or both.

Outcome
type: Class
subclass of: Finding
definition: The result of an action.

Bevacizumab
type: Class
subclass of: Pharmacologic Substance
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A recombinant humanized monoclonal antibody directed against the vascular endothelial growth factor (VEGF), a pro-angiogenic cytokine. Bevacizumab binds to VEGF and inhibits VEGF receptor binding, thereby preventing the growth and maintenance of tumor blood vessels.

Performance Status
type: Class
subclass of: Clinical Attribute
definition: A measure of how well a patient is able to perform ordinary tasks and carry out daily activities.

Temporal Qualifier
type: Class
subclass of: Qualitative Concept
definition: Terms used to indicate units of time or other terms associated with time.

ACE Inhibitor
type: Class
subclass of: Chemical Viewed Functionally
definition: Any substance that inhibits angiotensin-converting enzyme (ACE), an enzyme that catalyzes the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in a reduction in angiotensin II and angiotensin II-induced aldosterone secretion, causing vasodilation and natriuresis.

Age
type: Class
subclass of: Organism Attribute
definition: How long something has existed; elapsed time since birth.

Birth
type: Class
subclass of: Organism Function
definition: The event of being born.

Date
type: Class
subclass of: Temporal Concept
definition: The particular day, month and year an event has happened or will happen.

Laterality
type: Class
subclass of: Organism Attribute
subclass of: Spatial Concept
definition: Dominant use or manifestations of one side of the body versus the other; referring to a side of the body or of a structure.

Marital Status
type: Class
subclass of: Organism Attribute
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A demographic parameter indicating a person's current conjugal status.

Person
type: Class
subclass of: Human
definition: A human being.

Weight
type: Class
subclass of: Quantity
definition: The vertical force exerted by a mass as a result of gravity.

Intervention or Procedure
type: Class
subclass of: Health Care Activity
definition: An activity that produces an effect, or that is intended to alter the course of a disease in a patient or population. This is a general term that encompasses the medical, social, behavioral, and environmental acts that can have preventive, therapeutic, or palliative effects.

Right
type: Class
subclass of: Laterality
definition: Being or located on or directed toward the side of the body to the east when facing north.

Left
type: Class
subclass of: Laterality
subclass of: Spatial Concept
definition: Being or located on or directed toward the side of the body to the west when facing north.

Duration
type: Class
subclass of: Temporal Concept
definition: The period of time during which something continues.

Length
type: Class
subclass of: Size
definition: The linear extent in space from one end of something to the other end, or the extent of something from beginning to end.

Volume
type: Class
subclass of: Size
definition: The amount of three dimensional space occupied by an object or the capacity of a space or container.

Height
type: Class
subclass of: Size
definition: The vertical measurement or distance from the base to the top of an object; the vertical dimension of extension.

Identifier
type: Class
subclass of: Intellectual Product
definition: One or more characters used to identify, name, or characterize the nature, properties, or contents of a thing.

Zubrod Performance Status
type: Class
subclass of: Performance Status
definition: A scale used to assess how a patient's disease is progressing and assess how the disease affects the daily living abilities of the patient.

Anal Margin
type: Class
subclass of: Body Part, Organ, or Organ Component
alternative label: Anal Verge
definition: The transitional zone between the moist, hairless, modified skin of the anal canal and the perianal skin.

Count
type: Class
subclass of: Quantity
definition: To determine the number or amount of something; the result of this activity.

Dose
type: Class
subclass of: Quantity
definition: A quantity of an agent (such as substance or energy) administered, taken, or absorbed at one time.

Fraction
type: Class
subclass of: Quantity
definition: A part, a fragment of a whole.

Margin
type: Class
subclass of: Spatial Concept
definition: A boundary line or the area immediately inside the boundary.

Percentage
type: Class
subclass of: Quantity
definition: A fraction or ratio with 100 understood as the denominator.

Postal Code
type: Class
subclass of: Classification
definition: Any system designed to expedite the sorting and delivery of mail by assigning a series of alphanumeric codes to each delivery area. Also used to refer to any individual delivery area code.

Resectable
type: Class
subclass of: Disease Treatment Qualifier
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Capable of being removed by surgery.

Size
type: Class
subclass of: Quantity
definition: The physical magnitude of something.

Version
type: Class
subclass of: Conceptual Entity
definition: A form or variant of a type or original; one of a sequence of copies of a program, each incorporating new modifications.

Vital Status
type: Class
subclass of: Finding
subclass of: Clinical Attribute
see also: EuroCAT Umbrella Protocol for NSCLC
definition: The state or condition of being living or deceased; also includes the case where the vital status is unknown.

Intent
type: Class
subclass of: Functional Concept
see also: EuroCAT Umbrella Protocol for NSCLC
definition: An anticipated outcome that is the purpose for actions taken, thus guiding the action.

Respiratory System Disorder
type: Class
subclass of: Disease or Disorder
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A non-neoplastic or neoplastic disorder that affects the respiratory system. Representative examples include pneumonia, chronic obstructive pulmonary disease, pulmonary failure, lung adenoma, lung carcinoma, and tracheal carcinoma.

Non-Neoplastic Cardiovascular Disorder
type: Class
subclass of: Cardiovascular Disorder
definition: A non-neoplastic disorder that affects the heart and/or vessels. Representative examples include myocardial infarction, endocarditis, arteriosclerosis, thrombosis, and lymphedema.

Stage I
type: Class
subclass of: Disease Stage Qualifier
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Invasive cancer confined to the original anatomic site of growth without lymph node involvement.

Stage III
type: Class
subclass of: Disease Stage Qualifier
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Locally advanced cancer that has spread to nearby organs but not to distant anatomic sites.

Stage IV
type: Class
subclass of: Disease Stage Qualifier
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Cancer that has spread to distant anatomic sites beyond its original site of growth.

Stage IA
type: Class
subclass of: Stage I
definition: Invasive cancer confined to the original anatomic site of growth without lymph node involvement. The definition of stage IA depends on the particular type of cancer that it refers to; for example, for breast cancer, stage IA is defined as follows: T1, N0, M0. T1: Tumor 20 mm or less in greatest dimension. T1 includes T1mi. T1mi: Tumor 1 mm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No clinical or radiographic evidence of distant metastasis. M0 includes M0(i+); for bone cancer, stage IA is defined as follows: T1, N0, M0, G1, GX. T1: Tumor 8 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well differentiated-low grade. GX: Grade cannot be assessed. (partially adapted from AJCC 8th ed.)

Stage IB
type: Class
subclass of: Stage I
definition: Invasive cancer confined to the original anatomic site of growth without lymph node involvement. The definition of stage IB depends on the particular type of cancer that it refers to; for example, for breast cancer, stage IB is defined as follows: (T0, N1mi, M0); (T1, N1mi, M0). T0: No evidence of primary tumor. T1: Tumor 20 mm or less in greatest dimension. T1 includes T1mi. T1mi: Tumor 1 mm or less in greatest dimension. N1mi: Nodal micrometastases. M0: No clinical or radiographic evidence of distant metastasis. M0 includes M0(i+); for bone cancer, stage IB is defined as follows: (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX). T2: Tumor more than 8 cm in greatest dimension. T3: Discontinuous tumors in the primary bone site. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well differentiated-low grade. G2: Moderately differentiated-low grade. GX: Grade cannot be assessed. (partially adapted from AJCC 7th ed.)

Stage IIIA
type: Class
subclass of: Stage III
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Locally advanced cancer that has spread to nearby organs but not to distant anatomic sites. The definition of stage IIIA depends on the particular type of cancer that it refers to; for example, for breast cancer, stage IIIA is defined as follows: (T0, N2, M0); (T1, N2, M0); (T2, N2, M0); (T3, N1, M0); (T3, N2, M0). T0: No evidence of primary tumor. T1: Tumor 20 mm or less in greatest dimension. T1 includes T1mi. T1mi: Tumor 1 mm or less in greatest dimension. T2: Tumor more than 20 mm but not more than 50 mm in greatest dimension. T3: Tumor more than 50 mm in greatest dimension. N1: Metastasis to movable ipsilateral level I, II axillary lymph node(s). N2: Metastases in ipsilateral level I, II axillary lymph nodes that are clinically fixed or matted; or in clinically detected ipsilateral internal mammary nodes in the absence of clinically evident axillary lymph node metastases. M0: No clinical or radiographic evidence of distant metastasis. M0 includes M0(i+); for cervical cancer, stage IIIA is defined as follows: T3a, N0, M0. T3a: Tumor involves lower third of vagina, no extension to pelvic wall. N0: No regional lymph node metastasis. M0: No distant metastasis. (partially adapted from AJCC 7th ed.)

Stage IIIB
type: Class
subclass of: Stage III
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Locally advanced cancer that has spread to nearby organs but not to distant anatomic sites. The definition of stage IIIB depends on the particular type of cancer that it refers to; for example, for breast cancer, stage IIIB is defined as follows: (T4, N0, M0); (T4, N1, M0); (T4, N2, M0). T4: Tumor of any size with direct extension to the chest wall and/or to the skin (ulceration or skin nodules). N0: No regional lymph node metastasis. N1: Metastasis to movable ipsilateral level I, II axillary lymph node(s). N2: Metastases in ipsilateral level I, II axillary lymph nodes that are clinically fixed or matted; or in clinically detected ipsilateral internal mammary nodes in the absence of clinically evident axillary lymph node metastases. M0: No clinical or radiographic evidence of distant metastasis. M0 includes M0(i+); for cervical cancer, stage IIIB is defined as follows: (T3b, Any N, M0); (T1-3, N1, M0). T3: Tumor extends to pelvic wall and/or involves lower third of vagina, and/or causes hydronephrosis or non-functioning kidney. T3b: Tumor extends to pelvic wall and/or causes hydronephrosis or non-functioning kidney. N1: Regional lymph node metastasis. M0: No distant metastasis. (partially adapted from AJCC 7th ed.)

Stage IVA
type: Class
subclass of: Stage IV
definition: Cancer that has spread to distant anatomic sites beyond its original site of growth. The definition of stage IVA depends on the particular type of cancer that it refers to; for example, for bone cancer, stage IVA is defined as follows: Any T, N0, M1a, Any G. N0: No regional lymph node metastasis. M1a: Distant metastasis to lung; for vaginal cancer, stage IVA is defined as follows: T4, Any N, M0. T4: Tumor invades mucosa of the bladder or rectum and/or extends beyond the true pelvis (bullous edema is not sufficient evidence to classify a tumor as T4). M0: No distant metastasis. (partially adapted from AJCC 7th ed.)

Stage IVB
type: Class
subclass of: Stage IV
definition: Cancer that has spread to distant anatomic sites beyond its original site of growth. The definition of stage IVB depends on the particular type of cancer that it refers to; for example, for bone cancer, stage IVB is defined as follows: (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G). N1: Regional lymph node metastasis. M1b: Metastasis to other distant sites; for vaginal cancer, stage IVB is defined as follows: Any T, Any N, M1. M1: Distant metastasis. (partially adapted from AJCC 7th ed.)

Stage IIIC
type: Class
subclass of: Stage III
definition: Locally advanced cancer that has spread to nearby organs but not to distant anatomic sites. The definition of stage IIIC depends on the particular type of cancer that it refers to; for example, for breast cancer, stage IIIC is defined as follows: Any T, N3, M0. N3: Metastases in ipsilateral infraclavicular (level III) axillary lymph nodes(s) with or without level I, II axillary lymph node involvement; or in clinically detected ipsilateral internal mammary lymph node(s) with clinically evident level I, II axillary lymph node metastases; or metastases in ipsilateral supraclavicular lymph node(s) with or without axillary or internal mammary lymph node involvement. M0: No clinical or radiographic evidence of distant metastasis. M0 includes M0(i+); for appendix carcinoma, stage IIIC is defined as follows: Any T, N2, M0. N2: Metastasis in four or more regional lymph nodes. M0: No distant metastasis. (partially adapted from AJCC 7th ed.)

Stage IA1
type: Class
subclass of: Stage IA
definition: A stage term referring to invasive cervical and lung cancer. For cervical cancer, it includes: T1a1, N0, M0. T1a1: Tumor with stromal invasion 3.0 mm or less in depth and 7.0 mm or less in horizontal spread. N0: No regional lymph node metastasis. M0: No distant metastasis. For lung cancer, it includes: (T1mi, N0, M0); (T1a, N0, M0). T1mi: Minimally invasive adenocarcinoma: adenocarcinoma (3 cm or less in greatest dimension) with a predominantly lepidic pattern and 5 mm or less invasion in greatest dimension. T1a: Tumor measuring 1 cm or less in greatest dimension. A superficial, spreading tumor of any size whose invasive component is limited to the bronchial wall and may extend proximal to the main bronchus also is classified as T1a, but these tumors are uncommon. N0: No regional lymph node metastasis. M0: No distant metastasis. (adapted from AJCC)

Stage IA2
type: Class
subclass of: Stage IA
definition: A stage term referring to invasive cervical cancer and invasive lung cancer. For cervical cancer, it includes: T1a2, N0, M0. T1a2: Tumor with stromal invasion more than 3.0 mm and not more than 5.0 mm with a horizontal spread 7.0 mm or less. N0: No regional lymph node metastasis. M0: No distant metastasis. For lung cancer, it includes: T1b, N0, M0. T1b: Tumor measuring more than 1 cm but 2 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (adapted from AJCC)

Stage IIA
type: Class
subclass of: Stage II
definition: Invasive cancer more extensive than stage I, usually involving local lymph nodes without spread to distant anatomic sites. The definition of stage IIA depends on the particular type of cancer that it refers to; for example, for breast cancer, stage IIA is defined as follows: (T0, N1, M0); (T1, N1, M0); (T2, N0, M0). T0: No evidence of primary tumor. T1: Tumor 20 mm or less in greatest dimension. T1 includes T1mi. T1mi: Tumor 1 mm or less in greatest dimension. T2: Tumor more than 20 mm but not more than 50 mm in greatest dimension. N1: Metastasis to movable ipsilateral level I, II axillary lymph node(s). N0: No regional lymph node metastasis. M0: No clinical or radiographic evidence of distant metastasis. M0 includes M0(i+); for bone cancer, stage IIA is defined as follows: T1, N0, M0, G3, G4. T1: Tumor 8 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. G3: Poorly differentiated. G4: Undifferentiated. (partially adapted from AJCC 7th ed.)

T1mi Stage Finding
type: Class
subclass of: Generic Primary Tumor TNM Finding
definition: A term that refers to a TNM finding of a primary tumor limited to the site of growth and indicates microinvasion only.

Stage IIB
type: Class
subclass of: Stage II
definition: Invasive cancer more extensive than stage I, usually involving local lymph nodes without spread to distant anatomic sites. The definition of stage IIB depends on the particular type of cancer that it refers to; for example, for breast cancer, stage IIB is defined as follows: (T2, N1, MO); (T3, NO, MO). T2: Tumor more than 20 mm but not more than 50 mm in greatest dimension. T3: Tumor more than 50 mm in greatest dimension. N1: Metastasis to movable ipsilateral level I, II axillary lymph node(s). N0: No regional lymph node metastasis. M0: No clinical or radiographic evidence of distant metastasis. M0 includes M0(i+); for bone cancer, stage IIB is defined as follows: T2, N0, M0, G3, G4. T2: Tumor more than 8 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. G3: Poorly differentiated. G4: Undifferentiated. (partially adapted from AJCC 7th ed.)

Stage 0
type: Class
subclass of: Disease Stage Qualifier
definition: Cancer confined to the epithelium without invasion of the basement membrane.

Stage II
type: Class
subclass of: Disease Stage Qualifier
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Invasive cancer more extensive than stage I, usually involving local lymph nodes without spread to distant anatomic sites.

Disease Grade Qualifier
type: Class
subclass of: Classification
definition: A term that refers to the cellular differentiation of a malignant cellular infiltrate. A cancer is defined through grades I-IV (or 1-4), or as well, moderately, poorly differentiated or undifferentiated.

Grade 1
type: Class
subclass of: Disease Grade Qualifier
alternative label: G1
definition: A morphologic qualifier indicating that a cancerous lesion is well differentiated.

Grade 2
type: Class
subclass of: Disease Grade Qualifier
alternative label: G2
definition: A morphologic qualifier indicating that a cancerous lesion is moderately differentiated.

Grade 3
type: Class
subclass of: Disease Grade Qualifier
alternative label: G3
definition: A morphologic qualifier indicating that a cancerous lesion is poorly differentiated.

Grade 4
type: Class
subclass of: Disease Grade Qualifier
alternative label: G4
definition: A morphologic qualifier indicating that a cancerous lesion is undifferentiated.

Disease Treatment Qualifier
type: Class
subclass of: Classification
see also: EuroCAT Umbrella Protocol for NSCLC

Disease Stage Qualifier
type: Class
subclass of: Classification
see also: EuroCAT Umbrella Protocol for NSCLC

Tumor Burden
type: Class
subclass of: Tumor Volume
definition: The total volume of all macroscopic tumor tumors in the body. It is the sum of the primary tumor, macroscopic lymph nodes metastases and distant metastases.

Sex
type: Class
subclass of: Organism Attribute
see also: EuroCAT Umbrella Protocol for NSCLC
definition: The assemblage of physical properties or qualities by which male is distinguished from female; the physical difference between male and female; the distinguishing peculiarity of male or female.

Adenocarcinoma
type: Class
subclass of: Neoplasm by Morphology
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma.

Death
type: Class
subclass of: Outcome
subclass of: Vital Status
see also: EuroCAT Umbrella Protocol for NSCLC
definition: The absence of life or state of being dead. (NCI)

Non-Small Cell Lung Carcinoma
type: Class
equivalent class: Class
  intersection of: Malignant Lung Neoplasm
  intersection of: Restriction
    on property: has_histology
    some values from: Class
      union of: Adenocarcinoma
      union of: Squamous Cell Carcinoma
      union of: Large Cell Carcinoma
      union of: Non-Small Cell Carcinoma
definition: A group of at least three distinct histological types of lung cancer, including squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Non-small cell lung carcinomas have a poor response to conventional chemotherapy.

Squamous Cell Carcinoma
type: Class
subclass of: Neoplasm by Morphology
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma.

Cardiovascular Disorder
type: Class
subclass of: Disease or Disorder
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A non-neoplastic or neoplastic disorder affecting the heart or the vessels (arteries, veins and lymph vessels). Representative examples of non-neoplastic cardiovascular disorders are endocarditis and hypertension. Representative examples of neoplastic cardiovascular disorders are endocardial myxoma and angiosarcoma.

Diabetes Mellitus
type: Class
subclass of: Endocrine System Disorder
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A metabolic disorder characterized by abnormally high blood sugar levels due to diminished production of insulin or insulin resistance/desensitization.

Disease or Disorder
type: Class
equivalent class: Disease or Syndrome
subclass of: Pathologic Function
subclass of: Disease or Syndrome
definition: Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. The term is often used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function.

Endocrine System Disorder
type: Class
subclass of: Disease or Disorder
definition: A non-neoplastic or neoplastic disorder that affects the endocrine system. Representative examples of non-neoplastic disorders include diabetes mellitus, hyperthyroidism, and adrenal gland insufficiency. Representative examples of neoplastic disorders include carcinoid tumor, neuroendocrine carcinoma, and pheochromocytoma.

Heart Disorder
type: Class
subclass of: Cardiovascular Disorder
definition: A non-neoplastic or neoplastic disorder that affects the heart and/or the pericardium. Representative examples include endocarditis, pericarditis, atrial myxoma, cardiac myeloid sarcoma, and pericardial malignant mesothelioma.

Neoplasm
type: Class
equivalent class: Neoplastic Process
subclass of: Disease or Disorder
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A benign or malignant tissue growth resulting from uncontrolled cell proliferation. Benign neoplastic cells resemble normal cells without exhibiting significant cytologic atypia, while malignant cells exhibit overt signs such as dysplastic features, atypical mitotic figures, necrosis, nuclear pleomorphism, and anaplasia. Representative examples of benign neoplasms include papillomas, cystadenomas, and lipomas; malignant neoplasms include carcinomas, sarcomas, lymphomas, and leukemias.

Finding
type: Class
subclass of: Conceptual Entity
definition: Clinical, laboratory or molecular evidence, or absence of evidence of disease.

Weight Loss
type: Class
subclass of: Finding
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A reduction in total body weight.

Non-Neoplastic Respiratory Disorder
type: Class
subclass of: Respiratory System Disorder
definition: A non-neoplastic disorder that affects the respiratory system. Representative examples include pneumonia, chronic obstructive pulmonary disease, pulmonary failure, tracheitis, and tracheal agenesis.

Metastatic Malignant Neoplasm in the Lung
type: Class
subclass of: Metastatic Malignant Neoplasm
alternative label: Lung Metastasis
definition: The spread of a malignant neoplasm to the lung. This may be from a primary lung malignant neoplasm, or from a malignant neoplasm at a distant site.

Metastatic Malignant Neoplasm in the Bone
type: Class
subclass of: Metastatic Malignant Neoplasm
alternative label: Bone Metastasis
definition: The spread of a malignant neoplasm from a primary site to the skeletal system. The majority of metastatic neoplasms to the bone are carcinomas.

Distantly Metastatic Malignant Neoplasm
type: Class
subclass of: Metastatic Malignant Neoplasm
alternative label: Distant Metastasis
definition: A malignant tumor that has spread from its original (primary) site of growth to another site distant from the primary site.

Locally Metastatic Malignant Neoplasm
type: Class
subclass of: Metastatic Malignant Neoplasm
alternative label: Regional Cancer
definition: Refers to cancer that has grown beyond the original (primary) tumor to nearby lymph nodes or organs and tissues.

Secondary Neoplasm
type: Class
subclass of: Neoplastic Process
definition: A neoplasm that arises from a pre-existing lower grade lesion, or as a result of a primary lesion that has spread to secondary sites, or due to a complication of a cancer treatment.

Metastatic Malignant Neoplasm
type: Class
subclass of: Neoplasm
subclass of: Neoplastic Process
alternative label: Metastasis
definition: A malignant tumor that has spread from its original (primary) site of growth to another site close to or distant from the primary site.

Cisplatin
type: Class
subclass of: Platinum Compound
subclass of: Pharmacologic Substance
see also: EuroCAT Umbrella Protocol for NSCLC
definition: An alkylating-like inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition.

Large Cell Carcinoma
type: Class
subclass of: Neoplasm by Morphology
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A malignant epithelial neoplasm composed of large, atypical cells.

Site
type: Class
subclass of: Spatial Concept
definition: A position in relation to its surroundings.

Life
type: Class
subclass of: Outcome
subclass of: Vital Status
see also: EuroCAT Umbrella Protocol for NSCLC
definition: The organic phenomenon that distinguishes living organisms from nonliving ones; showing characteristics of life.

Pulmonary Function Test
type: Class
subclass of: Diagnostic Procedure
definition: A broad range of tests that are performed to assess how well lungs inhale and exhale air and how efficiently they transfer oxygen into the blood.

Carbon Monoxide Diffusing Capability Test
type: Class
subclass of: Pulmonary Function Test
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: DLCO
definition: A measurement of carbon monoxide (CO) transfer from inspired gas to pulmonary capillary blood. During the test, the subject inspires a gas containing CO and one or more tracer gases to allow determination of the gas exchanging capability of the lungs.

Forced Expiratory Volume in 1 Second
type: Class
subclass of: Pulmonary Function Test
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A test of lung function, the FEV1 is the volume exhaled during the first second of a forced expiratory maneuver started from the level of total lung capacity. It is the most frequently used index for assessing bronchoconstriction or bronchodilatation.

Metastatic Malignant Neoplasm in the Brain
type: Class
subclass of: Metastatic Malignant Neoplasm
alternative label: Brain Metastasis
definition: A malignant neoplasm that has spread to the brain from another anatomic site or system. The majority are carcinomas (usually lung or breast carcinomas).

Recurrent Disease
type: Class
subclass of: Outcome
definition: The return of a disease after a period of remission.

Molecular Abnormality
type: Class
subclass of: Cell or Molecular Dysfunction
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A molecular or cytogenic abnormality which occurs in either human disease states or disease models.

Small Cell Carcinoma
type: Class
subclass of: Neoplasm by Morphology
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A neuroendocrine carcinoma composed of small malignant cells which are often said to resemble "oat cells" under the microscope. Small cell carcinoma most often affects the lungs. Clinically, this is often a rapidly growing cancer that spreads to distant sites early.

No Evidence of Disease
type: Class
subclass of: Outcome
definition: Diagnostic tests fail to detect presence of disease.

BRAF Gene Mutation
type: Class
subclass of: Molecular Abnormality
see also: EuroCAT Umbrella Protocol for NSCLC

Cyclophosphamide
type: Class
subclass of: Pharmacologic Substance
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death.

Qualifier
type: Class
subclass of: Conceptual Entity
definition: A term that helps define and render a concept unique.

Surgical Margin
type: Class
subclass of: Margin
definition: One of the criteria for assessment of the effectiveness of given surgical procedure in achieving the local control of a neoplasm and the adequacy of tumor removal. It is defined by the tissue plane through which the dissection has been done and the actual or potential neoplastic tissue which has been left outside the boundary of a resected specimen within the patient. There are four types of surgical margins: intracapsular or intralesional, marginal, wide, and radical.

Adverse Event
type: Class
subclass of: Finding
definition: Any unfavorable or unintended symptom, sign, or disease including an abnormal laboratory finding) temporally associated with the use of a medical treatment or procedure that may or may not be considered related to the medical treatment or procedure. Such events can be intervention related, dose related, route related, patient related, or caused by an interaction with another drug(s) or procedure(s).

KRAS Gene Mutation
type: Class
subclass of: Molecular Abnormality
see also: EuroCAT Umbrella Protocol for NSCLC

Part
type: Class
subclass of: Spatial Concept
definition: One of the portions into which something is regarded as divided and which together constitute a whole.

Doxorubicin
type: Class
subclass of: Pharmacologic Substance
see also: EuroCAT Umbrella Protocol for NSCLC
definition: An anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects.

Circumferential Resection Margin
type: Class
subclass of: Surgical Margin
definition: The distance between the radial extent of the tumor and the surgical incision used to excise the tumor. This distance is measured microscopically.

Male Gender
type: Class
subclass of: Gender
definition: An individual who reports belonging to the cultural gender role distinction of male.

Female Gender
type: Class
subclass of: Gender
definition: An individual who reports belonging to the cultural gender role distinction of female.

Neoplasm by Morphology
type: Class
subclass of: Neoplastic Process
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A classification system grouping neoplasms according to their cellular characteristics.

Metastatic Malignant Neoplasm in the Liver
type: Class
subclass of: Metastatic Malignant Neoplasm
alternative label: Liver Metastasis
definition: A malignant neoplasm that has spread to the liver from another (primary) anatomic site. Such malignant neoplasms may be carcinomas, lymphomas, melanomas, or sarcomas.

Lymphatic Invasion
type: Class
subclass of: Finding
definition: A term referring to the presence of tumor emboli or tumor masses within lymphatic vessels.

Cancer TNM Finding
type: Class
subclass of: Finding
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A cancer finding in the TNM system that is relevant to the diagnosis of cancer.

No Evidence of Metastatic Disease
type: Class
subclass of: Outcome
definition: Diagnostic tests fail to detect presence of metastatic lesions.

Positive Surgical Margin
type: Class
subclass of: Surgical Margin
definition: Indicates the presence of tumor cells at the edge of a surgically excised specimen.

Negative Surgical Margin
type: Class
subclass of: Surgical Margin
definition: Indicates the absence of tumor cells at the edge of a surgically excised specimen.

M0 Stage Finding
type: Class
subclass of: Generic Distant Metastasis TNM Finding
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A distant metastasis TNM finding indicating that there is no evidence of distant metastasis.

M1 Stage Finding
type: Class
subclass of: Generic Distant Metastasis TNM Finding
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A clinical and/or pathologic distant metastasis TNM finding indicating the spread of cancer to distant anatomic sites.

M1a Stage Finding
type: Class
subclass of: M1 Stage Finding
definition: A TNM finding indicating the spread of cancer to distant anatomic sites. The definition of M1a TNM finding depends on the specific type of cancer that it refers to; for example, for colorectal cancer it refers to metastasis confined to one organ or site (e.g., liver, lung, ovary, nonregional node); for prostate cancer it refers to metastasis to non-regional lymph node(s); for bone cancer it refers to metastasis to the lung.

M1b Stage Finding
type: Class
subclass of: M1 Stage Finding
definition: A TNM finding indicating the spread of cancer to distant anatomic sites. The definition of M1b TNM finding depends on the specific type of cancer that it refers to; for example, for colorectal cancer it refers to metastases in more than one organ/site or the peritoneum; for prostate cancer it refers to metastasis to bone(s); for bone cancer it refers to metastasis to distant sites other than lung.

M1c Stage Finding
type: Class
subclass of: M1 Stage Finding
definition: A TNM finding indicating the spread of cancer to distant anatomic sites. The definition of M1c TNM finding depends on the specific type of cancer that it refers to; for example, for prostate cancer it refers to metastasis to anatomic site(s) other than bone, with or without bone disease; for retinoblastoma it refers to central nervous system metastasis; for melanoma of the uvea it refers to distant metastasis, with the largest diameter of the largest metastasis measuring 8.0 cm or more.

MX Stage Finding
type: Class
subclass of: Generic Distant Metastasis TNM Finding
definition: A distant metastasis TNM finding indicating that the status of distant metastasis cannot be assessed.

N0 Stage Finding
type: Class
subclass of: Generic Regional Lymph Nodes TNM Finding
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A regional lymph node TNM finding indicating that there is no evidence of regional lymph node metastasis.

N1 Stage Finding
type: Class
subclass of: Generic Regional Lymph Nodes TNM Finding
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A general term that refers to a TNM finding of cancer metastases usually in a limited number of regional lymph nodes. The definition of N1 TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to micrometastases or metastases in 1-3 axillary lymph nodes; for cutaneous melanoma it refers to metastasis in 1 regional lymph node; for colorectal cancer it refers to metastases in 1-3 regional lymph nodes; and for bladder cancer it refers to metastasis in 1 regional lymph node in the true pelvis.

N3 Stage Finding
type: Class
subclass of: Generic Regional Lymph Nodes TNM Finding
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A general term that refers to a TNM finding of cancer metastases in multiple lymph nodes. The definition of N3 TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to metastases in 10 or more axillary lymph nodes; for cutaneous melanoma it refers to metastases in 4 or more regional lymph nodes; for gastric cancer it refers to metastases in 7 or more regional lymph nodes; and for bladder cancer it refers to metastases in common iliac lymph nodes.

NX Stage Finding
type: Class
subclass of: Generic Regional Lymph Nodes TNM Finding
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A regional lymph node TNM finding indicating that the status of regional lymph nodes cannot be assessed.

T0 Stage Finding
type: Class
subclass of: Generic Primary Tumor TNM Finding
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A primary tumor TNM finding indicating that there is no evidence of primary tumor.

T1 Stage Finding
type: Class
subclass of: Generic Primary Tumor TNM Finding
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A clinical and/or pathologic primary tumor TNM finding indicating that the cancer is limited to the site of growth.

T1a Stage Finding
type: Class
subclass of: T1 Stage Finding
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A general term that refers to a TNM finding of a primary tumor limited to the site of growth. The definition of T1a TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to a primary tumor that is more than 0.1cm, but not more than 0.5 cm in greatest dimension; for kidney cancer it refers to a primary tumor that is 4 cm or less in greatest dimension; and for thyroid cancer it refers to a primary tumor that is 1 cm or less in greatest dimension.

T1b Stage Finding
type: Class
subclass of: T1 Stage Finding
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A general term that refers to a TNM finding of a primary tumor limited to the site of growth. The definition of T1b TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to a primary tumor that is more than 0.5 cm, but not more than 1.0 cm in greatest dimension; for kidney cancer it refers to a primary tumor that is more than 4 cm, but not more than 7 cm in greatest dimension; and for thyroid cancer it refers to a primary tumor that is more than 1 cm but not more than 2 cm in greatest dimension.

T1c Stage Finding
type: Class
subclass of: T1 Stage Finding
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A general term that refers to a TNM finding of a primary tumor limited to the site of growth. The definition of T1c TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to a primary tumor that is more than 1.0 cm, but not more than 2.0 cm in greatest dimension; for uterine corpus cancer it refers to a primary tumor that invades one-half or more of the myometrium; and for melanoma of the iris it refers to a primary tumor limited to the iris with secondary glaucoma.

T2 Stage Finding
type: Class
subclass of: Generic Primary Tumor TNM Finding
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A general term that refers to a TNM finding of primary tumor growth beyond the level of in situ cancer, minimal subepithelial invasion, or minimal greatest diameter. The definition of T2 TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to primary tumor that is more than 2.0 cm, but not more than 5.0 cm in greatest dimension; for cutaneous melanoma it refers to primary tumor that is 1.01 to 2 mm in thickness, with or without ulceration; for colorectal cancer it refers to primary tumor with invasion into the muscularis propria; and for bladder cancer it refers to primary tumor with invasion into the muscle layer.

T2a Stage Finding
type: Class
subclass of: T2 Stage Finding
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A general term that refers to a TNM finding of a primary tumor growth beyond the level of in situ cancer, minimal subepithelial invasion, or minimal greatest diameter. The definition of T2a TNM finding depends on the specific type of cancer that it refers to; for example, for kidney cancer it refers to a primary tumor that measures more than 7 cm but less than or equal to 10 cm in greatest dimension, and is limited to the kidney; for bladder cancer it refers to a primary tumor that invades the superficial muscularis propria (inner half); for cervical cancer it refers to a primary tumor that invades beyond the uterus but not to the pelvic wall or to the lower third of vagina and there is no parametrial invasion.

T2b Stage Finding
type: Class
subclass of: T2 Stage Finding
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A general term that refers to a TNM finding of a primary tumor growth beyond the level of in situ cancer, minimal subepithelial invasion, or minimal greatest diameter. The definition of T2b TNM finding depends on the specific type of cancer that it refers to; for example, for kidney cancer it refers to a primary tumor that measures more than 10 cm in greatest dimension, and is limited to the kidney; for bladder cancer it refers to a primary tumor that invades the deep muscularis propria (outer half); for cervical cancer it refers to a primary tumor that invades beyond the uterus but not to the pelvic wall or to the lower third of vagina and there is parametrial invasion.

T2c Stage Finding
type: Class
subclass of: T2 Stage Finding
definition: A general term that refers to a TNM finding of a primary tumor growth beyond the level of in situ cancer, minimal subepithelial invasion, or minimal greatest diameter. The definition of T2c TNM finding depends on the specific type of cancer that it refers to; for example, for prostate cancer it refers to a primary tumor that involves both lobes of the prostate gland; for ovarian cancer it refers to a primary tumor that involves one or both ovaries with extension or implants on the uterus and/or fallopian tubes, or other pelvic tissues, with malignant cells in either ascites or peritoneal washings; for fallopian tube cancer it refers to a primary tumor with pelvic extension and malignant cells in ascites or peritoneal washings.

T3 Stage Finding
type: Class
subclass of: Generic Primary Tumor TNM Finding
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A clinical and/or pathologic primary tumor TNM finding usually indicating that the cancer is locally invasive, without infiltration of adjacent structures.

T4 Stage Finding
type: Class
subclass of: Generic Primary Tumor TNM Finding
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A clinical and/or pathologic primary tumor TNM finding indicating direct invasion of adjacent structures by cancer.

TX Stage Finding
type: Class
subclass of: Generic Primary Tumor TNM Finding
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A primary tumor TNM finding indicating that the status of the primary tumor cannot be assessed.

Tis Stage Finding
type: Class
subclass of: Generic Primary Tumor TNM Finding
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A term that refers to a TNM finding of a primary tumor microscopically defined as carcinoma in situ.

Pathologic TNM Finding
type: Class
subclass of: Cancer TNM Finding
see also: EuroCAT Umbrella Protocol for NSCLC
definition: TNM staging performed as part of pathologic specimen.

N2 Stage Finding
type: Class
subclass of: Generic Regional Lymph Nodes TNM Finding
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A general term that refers to a TNM finding of cancer metastases in several regional lymph nodes. The definition of N2 TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to metastases in 4-9 axillary lymph nodes; for cutaneous melanoma it refers to metastases in 2-3 regional lymph nodes; for colorectal cancer it refers to metastases in 4 or more regional lymph nodes; and for bladder cancer it refers to metastases in multiple regional lymph nodes in the true pelvis.

Generic TNM Finding
type: Class
subclass of: Cancer TNM Finding
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A cancer finding in the TNM system that is not specifically identified as a clinical, pathologic, recurrent (retreatment), or autopsy classification using an accepted prefix in accordance with TNM classification guidelines. Though the 6th Edition of the AJCC Cancer Staging Manual indicates that unspecified TNM staging descriptors may be considered synonymous with the corresponding fully specified clinical category, such omission may lead to ambiguity in meaning, and in practice unqualified descriptors are frequently used with other intended meanings. The generic TNM concepts in the NCI Thesaurus are intended to explicitly reflect this lack of specification.

Clinical TNM Finding
type: Class
subclass of: Cancer TNM Finding
see also: EuroCAT Umbrella Protocol for NSCLC
definition: TNM staging performed with access to clinical information only.

Generic Distant Metastasis TNM Finding
type: Class
subclass of: Generic TNM Finding
see also: EuroCAT Umbrella Protocol for NSCLC

Generic Regional Lymph Nodes TNM Finding
type: Class
subclass of: Generic TNM Finding
see also: EuroCAT Umbrella Protocol for NSCLC

Generic Primary Tumor TNM Finding
type: Class
subclass of: Generic TNM Finding
see also: EuroCAT Umbrella Protocol for NSCLC

Pathologic Distant Metastasis TNM Finding
type: Class
subclass of: Pathologic TNM Finding
see also: EuroCAT Umbrella Protocol for NSCLC

Pathologic Regional Lymph Nodes TNM Finding
type: Class
subclass of: Pathologic TNM Finding
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A pathologic finding about one or more characteristics of a specific cancer, following the rules of the TNM classification system as they pertain to staging of regional lymph nodes.

Pathologic Primary Tumor TNM Finding
type: Class
subclass of: Pathologic TNM Finding
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A pathologic finding about one or more characteristics of a specific cancer, following the rules of the TNM classification system as they pertain to staging of the primary tumor.

Regional Lymph Node Dissection
type: Class
subclass of: Lymphadenectomy
definition: Surgical removal of the lymph nodes located in a particular anatomic region. This procedure is commonly performed as a component of cancer staging.

Lobe of the Right Lung
type: Class
subclass of: Lobe of lung
see also: EuroCAT Umbrella Protocol for NSCLC
definition: One of the three lobes that comprise the right lung.

Lobe of the Left Lung
type: Class
subclass of: Lobe of lung
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Either of the two (upper or lower) lobes that comprise the left lung.

Etoposide
type: Class
subclass of: Epipodophyllotoxin Compound
subclass of: Pharmacologic Substance
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A semisynthetic derivative of podophyllotoxin, a substance extracted from the mandrake root Podophyllum peltatum. Possessing potent antineoplastic properties, etoposide binds to and inhibits topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. (NCI04)

Small Cell Lung Carcinoma
type: Class
equivalent class: Class
  intersection of: Malignant Lung Neoplasm
  intersection of: Restriction
    on property: has_histology
    some values from: Small Cell Carcinoma
definition: A highly aggressive subtype of lung carcinoma characterized by the presence of malignant small cells and necrosis. Metastatic disease is usually present at the time of diagnosis.

Therapeutic Procedure
type: Class
subclass of: Intervention or Procedure
subclass of: Therapeutic or Preventive Procedure
definition: An action or administration of therapeutic agents to produce an effect that is intended to alter or stop a pathologic process.

Fluorouracil
type: Class
subclass of: Pharmacologic Substance
alternative label: 5-FU
alternative label: 5-Fluorouracil

Medical Contraindication
type: Class
subclass of: Finding
definition: A symptom or medical condition that makes a particular treatment or procedure inadvisable because a person is likely to have a bad reaction.

Disease Response
type: Class
subclass of: Finding
alternative label: Response
definition: The pathologic and/or clinical changes that result from treatment. The changes may include eradication of detectable disease, stabilization of disease, or disease progression.

Wedge Resection of Lung
type: Class
subclass of: Thoracic Surgical Procedure
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Surgical removal of a wedge-shaped section of lung.

Married
type: Class
subclass of: Marital Status
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Indicates a person currently joined in a legally binding matrimonial union. Classify common law marriage as married. Includes married couples living together and not living together.

Never Married
type: Class
subclass of: Marital Status
definition: Indicates a person who has never been married or whose marriages have been annulled.

Widowed
type: Class
subclass of: Marital Status
definition: Indicates a person who is no longer married because of the death of his/her spouse and has not remarried.

Divorced
type: Class
subclass of: Marital Status
definition: Indicates a person whose marriage has been legally dissolved and has not remarried.

Separated
type: Class
subclass of: Marital Status
definition: Indicates a person living apart from his/her spouse by legal arrangement.

Lymphocyte Count
type: Class
subclass of: Laboratory or Test Result
definition: The determination of the number of lymphocytes in a blood sample.

Adverse Event Attribution Category
type: Class
subclass of: Classification
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A characteristic used to qualify the determination of whether an adverse event is related to medical product or procedure or related to the cancer or related to comorbidities.

Unrelated to Intervention
type: Class
subclass of: Adverse Event Attribution Category
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A characteristic used to qualify the adverse event as clearly not related to the medical intervention.

Unlikely Related to Intervention
type: Class
subclass of: Adverse Event Attribution Category
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A characteristic used to qualify the adverse event as unlikely related to the medical intervention. According to WHO causality assessment criteria of suspected adverse reactions it is applicable to a clinical event, including laboratory test abnormality, with a temporal relationship to the medical intervention which makes a causal relationship improbable, and in which other interventions or underlying disease provide plausible explanations.

Possibly Related to Intervention
type: Class
subclass of: Adverse Event Attribution Category
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A characteristic indicating that an adverse event may be related to the medical intervention. According to WHO causality assessment criteria of suspected adverse reactions it is applicable to a clinical event, including laboratory test abnormality, with a reasonable time sequence to administration of the drug, but which could also be explained by concurrent disease or other drugs or chemicals. Information on drug withdrawal may be lacking or unclear.

Probably Related to Intervention
type: Class
subclass of: Adverse Event Attribution Category
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A characteristic used to qualify the adverse event as likely related to the medical intervention. According to WHO causality assessment criteria of suspected adverse reactions it is applicable to a clinical event, including laboratory test abnormality, with a reasonable time sequence to the medical intervention, unlikely to be attributed to concurrent disease or other medical interventions, and which follows a clinically reasonable response on withdrawal (dechallenge). Rechallenge information is not required to fulfill this definition.

Definitely Related to Intervention
type: Class
subclass of: Adverse Event Attribution Category
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A characteristic used to qualify the adverse event as certainly related to the medical intervention. According to WHO causality assessment criteria of suspected adverse reactions it is applicable to a clinical event, including laboratory test abnormality, occurring in a plausible time relationship to medical intervention, and which cannot be explained by concurrent disease or other interventions. The response to withdrawal of the medical product (dechallenge) should be clinically plausible. The event must be definitive pharmacologically or phenomenologically, using a satisfactory rechallenge procedure if necessary.

Domestic Partnership
type: Class
subclass of: Marital Status
definition: Indicates a person who is a member of an unmarried couple, including same sex couples, living together in longstanding relationships, that are registered or unregistered.

Temporary
type: Class
subclass of: Temporal Qualifier
definition: Not permanent; not lasting; lacking continuity or regularity.

Adverse Event by CTCAE Category
type: Class
subclass of: Adverse Event by CTCAE v3 Severity Grade

Adverse Event Associated with Pulmonary and Upper Respiratory Systems
type: Class
subclass of: Adverse Event by CTCAE Category

Adverse Event Associated with the Gastrointestinal System
type: Class
subclass of: Adverse Event by CTCAE Category

Adverse Event Associated with the Heart in General
type: Class
subclass of: Adverse Event by CTCAE Category

Universally Unique Identifier
type: Class
subclass of: Unique Identifier
definition: A 128 bit identifier. Depending on the mechanism used to generate it, it is either guaranteed to be different from all other UUIDs/GUIDs generated until 3400 AD or extremely likely to be different. Its relatively small size lends itself well to sorting, ordering, and hashing of all sorts, storing in databases, simple allocation, and ease of programming in general.

CTCAE Grade 1 Hypertension
type: Class
subclass of: Hypertension Adverse Event
definition: Asymptomatic, transient (<24 hrs) increase by >20 mmHg (diastolic) or to >150/100 if previously WNL; intervention not indicated Pediatric: Asymptomatic, transient (<24 hrs) BP increase >ULN; intervention not indicated

CTCAE Grade 2 Hypertension
type: Class
subclass of: Hypertension Adverse Event
definition: Recurrent or persistent (>=24 hrs) or symptomatic increase by >20 mmHg (diastolic) or to >150/100 if previously WNL; monotherapy may be indicated Pediatric: Recurrent or persistent (>=24 hrs) BP >ULN; monotherapy may be indicated

CTCAE Grade 3 Hypertension
type: Class
subclass of: Hypertension Adverse Event
definition: Requiring more than one drug or more intensive therapy than previously Pediatric: Same as adult

CTCAE Grade 4 Hypertension
type: Class
subclass of: Hypertension Adverse Event
definition: Life-threatening consequences (e.g., hypertensive crisis) Pediatric: Same as adult

CTCAE Grade 5 Hypertension
type: Class
subclass of: Hypertension Adverse Event
definition: Death

Hypertension Adverse Event
type: Class
subclass of: Adverse Event Associated with the Heart in General

Recurrent Disease, Primary Site
type: Class
subclass of: Recurrent Disease
definition: Recurrence of symptoms of a disease at the original site.

Recurrent Disease, Distant Site
type: Class
subclass of: Recurrent Disease
definition: Recurrence of symptoms of a disease, at a site different and away from the original site.

CTCAE Grade 1 Dysphagia
type: Class
subclass of: Dysphagia Adverse Event
definition: Symptomatic, able to eat regular diet

CTCAE Grade 2 Dysphagia
type: Class
subclass of: Dysphagia Adverse Event
definition: Symptomatic and altered eating/swallowing (e.g., altered dietary habits, oral supplements); IV fluids indicated <24 hrs

CTCAE Grade 3 Dysphagia
type: Class
subclass of: Dysphagia Adverse Event
definition: Symptomatic and severely altered eating/swallowing (e.g., inadequate oral caloric or fluid intake); IV fluids, tube feedings, or TPN indicated >=24 hrs

CTCAE Grade 4 Dysphagia
type: Class
subclass of: Dysphagia Adverse Event
definition: Life-threatening consequences (e.g., obstruction, perforation)

CTCAE Grade 5 Dysphagia
type: Class
subclass of: Dysphagia Adverse Event
definition: Death

Dysphagia Adverse Event
type: Class
subclass of: Adverse Event Associated with the Gastrointestinal System

CTCAE Grade 1 Dyspnea
type: Class
subclass of: Dyspnea Adverse Event
definition: Dyspnea on exertion, but can walk 1 flight of stairs without stopping

CTCAE Grade 2 Dyspnea
type: Class
subclass of: Dyspnea Adverse Event
definition: Dyspnea on exertion but unable to walk 1 flight of stairs or 1 city block (0.1km) without stopping

CTCAE Grade 3 Dyspnea
type: Class
subclass of: Dyspnea Adverse Event
definition: Dyspnea with ADL.

CTCAE Grade 4 Dyspnea
type: Class
subclass of: Dyspnea Adverse Event
definition: Dyspnea at rest; intubation/ventilator indicated.

CTCAE Grade 5 Dyspnea
type: Class
subclass of: Dyspnea Adverse Event
definition: Death.

Dyspnea Adverse Event
type: Class
subclass of: Adverse Event Associated with Pulmonary and Upper Respiratory Systems

Leucovorin Calcium
type: Class
subclass of: Pharmacologic Substance
alternative label: Calcium Folinate

Pemetrexed
type: Class
subclass of: Pharmacologic Substance
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS), which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis.

Irinotecan
type: Class
subclass of: Pharmacologic Substance
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent.

Prone Position
type: Class
subclass of: Spatial Concept
alternative label: Prone
definition: An anterior recumbent body position whereby the person lies on its stomach and faces downward.

Supine Position
type: Class
subclass of: Spatial Concept
alternative label: Supine
definition: A posterior recumbent body position whereby the person lies on its back and faces upward.

Cure
type: Class
subclass of: Radical
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Serving or tending to restore health; a remedy.

Transanal Excision
type: Class
subclass of: Abdominal Surgical Procedure
subclass of: Therapeutic Surgical Procedure
definition: Surgery for rectal cancer that spares the anus and leaves the sphincter intact. Surgery is performed through the anus and removes only the rectal tumor and small amounts of surrounding tissue.

Image Guided Radiation Therapy
type: Class
subclass of: Radiation Therapy
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: IGRT
definition: A procedure that uses a computer to create a picture of a tumor to help guide the radiation beam during radiation therapy. The pictures are made using CT, ultrasound, X-ray, or other imaging techniques. Image-guided radiation therapy makes radiation therapy more accurate and causes less damage to healthy tissue.

Tomotherapy
type: Class
subclass of: Radiation Therapy
definition: A type of external beam radiation therapy in which the radiation is delivered slice-by-slice, providing sequential delivery of radiation to different parts of the tumor. This method differs from other forms of radiation therapy in which the entire tumor volume is irradiated at one time.

FU-LV Regimen
type: Class
subclass of: Chemotherapy Regimen Used to Treat Colorectal Carcinoma
subclass of: Restriction
  on property: uses
  some values from: Fluorouracil
subclass of: Restriction
  on property: uses
  some values from: Leucovorin Calcium
alternative label: Fluorouracil-Leucovorin Regimen
alternative label: Mayo Clinic Regimen
alternative label: Roswell Park Regimen
alternative label: de Gramont Regimen
definition: A regimen consisting of fluorouracil and leucovorin, used in both the adjuvant and metastatic disease setting, for the treatment of colorectal cancer. This regimen is also combined with radiation for the treatment of gastric and esophageal cancer. The Mayo Clinic regimen, Roswell Park regimen, and de Gramont regimen are different in the doses and times at which the two drugs are given.

Study
type: Class
subclass of: Research Activity
definition: A detailed examination, analysis, or critical inspection of a subject designed to discover facts about it.

Chemotherapy Regimen Used to Treat Colorectal Carcinoma
type: Class
subclass of: Chemotherapy Regimen or Agent Combination

FOLFIRI Regimen
type: Class
subclass of: Chemotherapy Regimen Used to Treat Colorectal Carcinoma
subclass of: Restriction
  on property: uses
  some values from: Fluorouracil
subclass of: Restriction
  on property: uses
  some values from: Irinotecan
alternative label: FOLFIRI
alternative label: Folinic Acid-Fluorouracil-Irinotecan Regimen
definition: A chemotherapy regimen consisting of leucovorin calcium (calcium folinate), 5-fluorouracil, and irinotecan used in the treatment of advanced-stage and metastatic colorectal cancer.

XELOX regimen
type: Class
subclass of: Chemotherapy Regimen Used to Treat Colorectal Carcinoma
subclass of: Restriction
  on property: uses
  some values from: Oxaliplatin
subclass of: Restriction
  on property: uses
  some values from: Capecitabine
subclass of: Restriction
  on property: uses
  some values from: Leucovorin Calcium
alternative label: XELOX
alternative label: Xeloda-Oxaliplatin Regimen
alternative label: Xeloda/Oxalipaltin
definition: A regimen consisting of capecitabine and oxaliplatin used for the treatment of advanced stage colorectal cancer. This regimen differs from a similar regimen, CAPOX, with regards to the dosing schedule for oxaliplatin.

Inoperable
type: Class
subclass of: Disease Treatment Qualifier
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Not suitable for surgery.

Hemoglobin Measurement
type: Class
subclass of: Laboratory Procedure
definition: A quantitative measurement of the amount of hemoglobin present in a sample.

Therapeutic Surgical Procedure
type: Class
subclass of: Surgical Procedure
subclass of: Therapeutic Procedure

Never Smoker
type: Class
subclass of: Smoking Status
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A person who was not smoking at the time of the interview and has smoked less than 100 cigarettes in their life.

Non-Small Cell Carcinoma
type: Class
subclass of: Neoplasm by Morphology
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A malignant epithelial neoplasm characterized by the absence of neoplastic small epithelial cells. A representative example is the lung non-small cell carcinoma.

Erlotinib
type: Class
subclass of: Pharmacologic Substance
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A quinazoline derivative with antineoplastic properties. Competing with adenosine triphosphate, erlotinib reversibly binds to the intracellular catalytic domain of epidermal growth factor receptor (EGFR) tyrosine kinase, thereby reversibly inhibiting EGFR phosphorylation and blocking the signal transduction events and tumorigenic effects associated with EGFR activation.

Gemcitabine
type: Class
subclass of: Pharmacologic Substance
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A broad-spectrum antimetabolite and deoxycytidine analogue with antineoplastic activity. Upon administration, gemcitabine is converted into the active metabolites difluorodeoxycytidine diphosphate (dFdCDP) and difluorodeoxycytidine triphosphate (dFdCTP) by deoxycytidine kinase. dFdCTP competes with deoxycytidine triphosphate (dCTP) and is incorporated into DNA. This locks DNA polymerase thereby resulting in "masked termination" during DNA replication. On the other hand, dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis. The reduction in the intracellular concentration of dCTP potentiates the incorporation of dFdCTP into DNA.

Proton Beam Radiation Therapy
type: Class
subclass of: Radiation Therapy
definition: A type of external beam radiation therapy using a beam of protons. It has the advantage of precisely localizing the radiation dose on the targeted tissue and avoiding damage to the healthy surrounding tissues.

Current Smoker
type: Class
subclass of: Smoking Status
see also: EuroCAT Umbrella Protocol for NSCLC
definition: An adult who has smoked 100 cigarettes in his or her lifetime and who currently smokes cigarettes. Includes daily smokers and non-daily smokers (also known as occasional smokers).

Former Smoker
type: Class
subclass of: Smoking Status
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A person who was not smoking at the time of the interview but has smoked at least 100 cigarettes in their life.

Conditionally Related to Intervention
type: Class
subclass of: Adverse Event Attribution Category
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A characteristic used to qualify the adverse event as unclassified in term of its relation to the medical intervention. According to WHO causality assessment criteria of suspected adverse reactions it is applicable to clinical event, including laboratory test abnormality, reported as an adverse reaction, about which more data is essential for a proper assessment or the additional data are under examination.

Relation to Intervention Unclassifiable
type: Class
subclass of: Adverse Event Attribution Category
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A characteristic used to qualify the adverse event as unclassifiable in term of its relation to the medical intervention. According to WHO causality assessment criteria of suspected adverse reactions it is applicable to an adverse reaction which cannot be judged because information about it is insufficient or contradictory, and cannot be supplemented or verified.

Radical
type: Class
subclass of: Intent
definition: Directed to the root or source of a morbid process; to remove the root of a disease or all diseased tissue, as radical surgery.

Series Instance UID
type: Class
subclass of: Instance Unique Identifier
definition: A unique identifier for series of images.

Standardized Uptake Value
type: Class
subclass of: Image Feature
subclass of: Quantity
definition: An effectively dimensionless measure of regional tracer uptake calculated as the activity concentration within a 2D region of interest (ROI) or 3D volume of interest (VOI) measured on a PET image (nCi1mL) / [injected dose (nCi) / body weight (g)].

Unique Identifier
type: Class
subclass of: Identifier
definition: A set of characters used as a code that is unique in the context or the system for which it is created. It serves as a means of identification and reference (often instead of a name) for an entity, person, thing, function, procedure, activity, variable, or body of data.

Biospecimen
type: Class
subclass of: Body Substance
definition: Any material sample taken from a biological entity for testing, diagnostic, propagation, treatment or research purposes, including a sample obtained from a living organism or taken from the biological object after halting of all its life functions. Biospecimen can contain one or more components including but not limited to cellular molecules, cells, tissues, organs, body fluids, embryos, and body excretory products.

Image Feature
type: Class
subclass of: Idea or Concept
definition: In image processing, a piece of information which is relevant for solving the computational task related to a certain application, either specific structures in the image itself (e.g., simple structures such as points or edges to more complex structures such as objects) or the result of a general neighborhood operation (feature extractor or feature detector) applied to the image.

Instance Unique Identifier
type: Class
subclass of: Unique Identifier
definition: Data type unique identifier within a particular context.

Malignant Lung Neoplasm
type: Class
equivalent class: Malignant neoplasm of bronchus and lung
subclass of: Neoplasm
subclass of: Neoplastic Process
definition: A primary or metastatic malignant neoplasm involving the lung.

Pack Year
type: Class
subclass of: Quantity
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A quantification of lifetime tobacco exposure defined as (number of cigarettes smoked per day x number of years smoked)/20. One pack-year is smoking 20 cigarettes a day for one year.

Malignant Rectal Neoplasm
type: Class
equivalent class: Malignant neoplasm of rectum
subclass of: Neoplasm
subclass of: Neoplastic Process
definition: A primary or metastatic malignant neoplasm that affects the rectum. Representative examples include carcinoma, lymphoma, and sarcoma.

Malignant Rectosigmoid Neoplasm
type: Class
equivalent class: Malignant neoplasm of rectosigmoid junction
subclass of: Neoplasm
subclass of: Neoplastic Process
definition: A primary or metastatic malignant neoplasm that affects the rectosigmoid area. Representative examples include carcinoma, lymphoma, and sarcoma.

No Measurable or Evaluable Disease
type: Class
subclass of: Outcome

Cause of Death
type: Class
subclass of: Finding
definition: The circumstance or condition that results in the death of a living being.

Medical Record Number
type: Class
subclass of: Person Identifier
definition: An identifying number within an institution that is used to reference a subject's medical information.

Body Weight
type: Class
subclass of: Weight
see also: EuroCAT Umbrella Protocol for NSCLC
definition: The weight of a subject.

ALK Gene Mutation
type: Class
subclass of: Molecular Abnormality
see also: EuroCAT Umbrella Protocol for NSCLC

Elapsed Time
type: Class
subclass of: Temporal Concept
definition: The interval between two reference points in time.

Subject Identifier
type: Class
subclass of: Person Identifier
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: Studynumber
definition: A sequence of characters used to identify, name, or characterize the study subject.

Adverse Event by CTCAE v3 Severity Grade
type: Class
subclass of: Class
  intersection of: Adverse Event
  intersection of: Restriction
    on property: has_version
    some values from: CTCAE v3.0

Adverse Event by CTCAE v4 Severity Grade
type: Class
subclass of: Class
  intersection of: Adverse Event
  intersection of: Restriction
    on property: has_version
    some values from: CTCAE v4.0

Imaging Region of Interest
type: Class
subclass of: Image Feature
subclass of: Spatial Concept
definition: A specific area of interest defined by a sequence of image overlays or a sequence of contours described as a single point (for a point ROI) or more than one point (representing and open or closed polygon).

Teniposide
type: Class
subclass of: Epipodophyllotoxin Compound
subclass of: Pharmacologic Substance
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A semisynthetic derivative of podophyllotoxin with antineoplastic activity. Teniposide forms a ternary complex with the enzyme topoisomerase II and DNA, resulting in dose-dependent single- and double-stranded breaks in DNA, DNA: protein cross-links, inhibition of DNA strand religation, and cytotoxicity. This agent acts in the late S or early G phase of the cell cycle. (NCI04)

Abdominoperineal Resection
type: Class
subclass of: Abdominal Surgical Procedure
subclass of: Therapeutic Surgical Procedure
definition: A therapeutic surgical procedure in which the anus, rectum, part of the sigmoid colon, and the regional lymph nodes are removed through abdominal and perineal incisions.

Vinblastine
type: Class
subclass of: Vinca Alkaloid Compound
subclass of: Pharmacologic Substance
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A natural alkaloid isolated from the plant Vinca rosea Linn. Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle. This agent may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI04)

Malignant Cervical Neoplasm
type: Class
subclass of: Neoplasm
subclass of: Neoplastic Process
definition: Primary or metastatic malignant neoplasm involving the cervix. --2003

Vinca Alkaloid Compound
type: Class
subclass of: Chemical Viewed Structurally
definition: A type of drug that blocks cell growth by stopping mitosis (cell division). Vinca alkaloids interfere with microtubules (cellular structures that help move chromosomes during mitosis). They are used to treat cancer. A vinca alkaloid is a type of mitotic inhibitor and a type of antimicrotubule agent.

Vincristine
type: Class
subclass of: Vinca Alkaloid Compound
subclass of: Pharmacologic Substance
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A natural alkaloid isolated from the plant Vinca rosea Linn. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI04)

Vindesine
type: Class
subclass of: Vinca Alkaloid Compound
subclass of: Pharmacologic Substance
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A synthetic derivative of vinblastine, a naturally occurring vinca alkaloid. Vindesine binds to and stabilizes tubulin, thereby interrupting tubulin polymerization and preventing the formation of the mitotic spindle and cell division; treated cells are unable to undergo mitosis and are arrested in metaphase. This agent also disrupts macromolecular synthesis. (NCI04)

Operable
type: Class
subclass of: Disease Treatment Qualifier
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Describes a condition that can be treated by surgery.

Sleeve Lobectomy
type: Class
subclass of: Thoracic Surgical Procedure
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Surgery to remove a lung tumor in a lobe of the lung and a part of the main bronchus (airway). The ends of the bronchus are rejoined and any remaining lobes are reattached to the bronchus. This surgery is done to save part of the lung.

Metastasectomy
type: Class
subclass of: Abdominal Surgical Procedure
subclass of: Therapeutic Surgical Procedure
definition: The surgical removal of metastases.

Stature
type: Class
subclass of: Height
see also: EuroCAT Umbrella Protocol for NSCLC
definition: The height of a person while standing.

Tumor Volume
type: Class
subclass of: Volume
definition: The size of a cancer measured by the amount of space taken up by the tumor. For example, the tumor volume of prostate cancer is the percentage of the prostate taken up by the tumor.

Chemoradiotherapy
type: Class
subclass of: Multimodality Therapy
subclass of: Radiation Therapy
subclass of: Chemotherapy
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Treatment that combines chemotherapy with radiation therapy

Absorbed Radiation Dose
type: Class
subclass of: Dose
definition: The amount of energy from any type of ionizing radiation (e.g., alpha, beta, gamma, neutrons, etc.) deposited in any medium (e.g. water, tissue, air). This designates energy deposition by the radiation without regard to the type of matter or any biological considerations.

CyberKnife
type: Class
subclass of: Radiation Therapy
definition: A proprietary, robotic radiosurgery system designed to deliver precise beams of high dose radiation to tumors with extreme accuracy.

Prophylactic
type: Class
subclass of: Intent
definition: In medicine, something that prevents or protects.

ERBB2 Gene Mutation
type: Class
subclass of: Molecular Abnormality
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: HER2 Gene Mutation
definition: A molecular genetic abnormality indicating the presence of a mutation in the ERBB2 gene on chromosome 17q12.

AKT1 Gene Mutation
type: Class
subclass of: Molecular Abnormality
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A change in the nucleotide sequence of the AKT1 gene.

EGFR Gene Mutation
type: Class
subclass of: Molecular Abnormality
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A change in the nucleotide sequence of the EGFR gene.

Adverse Event by System Organ Class
type: Class
subclass of: Adverse Event by CTCAE v4 Severity Grade

Cough
type: Class
subclass of: Respiratory, thoracic and mediastinal disorders
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A disorder characterized by sudden, often repetitive, spasmodic contraction of the thoracic cavity, resulting in violent release of air from the lungs and usually accompanied by a distinctive sound.

Dysphagia
type: Class
subclass of: Gastrointestinal disorders
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A disorder characterized by difficulty in swallowing.

Dyspnea
type: Class
subclass of: Respiratory, thoracic and mediastinal disorders
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A disorder characterized by an uncomfortable sensation of difficulty breathing.

Esophageal stenosis
type: Class
subclass of: Gastrointestinal disorders
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A disorder characterized by a narrowing of the lumen of the esophagus.

Gastrointestinal disorders
type: Class
subclass of: Adverse Event by System Organ Class

Grade 1 Cough
type: Class
subclass of: Cough
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Mild symptoms; nonprescription intervention indicated

Grade 1 Dysphagia
type: Class
subclass of: Dysphagia
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Symptomatic, able to eat regular diet

Grade 1 Dyspnea
type: Class
subclass of: Dyspnea
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Shortness of breath with moderate exertion

Grade 1 Esophageal stenosis
type: Class
subclass of: Esophageal stenosis
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Asymptomatic; clinical or diagnostic observations only; intervention not indicated

Grade 2 Cough
type: Class
subclass of: Cough
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Moderate symptoms, medical intervention indicated; limiting instrumental ADL

Grade 2 Dysphagia
type: Class
subclass of: Dysphagia
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Symptomatic and altered eating/swallowing

Grade 2 Dyspnea
type: Class
subclass of: Dyspnea
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Shortness of breath with minimal exertion; limiting instrumental ADL

Grade 2 Esophageal stenosis
type: Class
subclass of: Esophageal stenosis
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Symptomatic; altered GI function

Grade 3 Cough
type: Class
subclass of: Cough
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Severe symptoms; limiting self care ADL

Grade 3 Dysphagia
type: Class
subclass of: Dysphagia
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Severely altered eating/swallowing; tube feeding or TPN or hospitalization indicated

Grade 3 Dyspnea
type: Class
subclass of: Dyspnea
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Shortness of breath at rest; limiting self care ADL

Grade 3 Esophageal stenosis
type: Class
subclass of: Esophageal stenosis
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Severely altered GI function; tube feeding; hospitalization indicated; elective operative intervention indicated

Grade 4 Dysphagia
type: Class
subclass of: Dysphagia
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Life-threatening consequences; urgent intervention indicated

Grade 4 Dyspnea
type: Class
subclass of: Dyspnea
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Life-threatening consequences; urgent intervention indicated

Grade 4 Esophageal stenosis
type: Class
subclass of: Esophageal stenosis
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Life-threatening consequences; urgent operative intervention indicated

Grade 5 Dysphagia
type: Class
subclass of: Dysphagia
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Death

Grade 5 Dyspnea
type: Class
subclass of: Dyspnea
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Death

Grade 5 Esophageal stenosis
type: Class
subclass of: Esophageal stenosis
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Death

Respiratory, thoracic and mediastinal disorders
type: Class
subclass of: Adverse Event by System Organ Class

Malignant neoplasm of rectosigmoid junction
type: Class
subclass of: Neoplasm
subclass of: Neoplastic Process

Malignant neoplasm of rectum
type: Class
subclass of: Neoplasm
subclass of: Neoplastic Process

Malignant neoplasm of bronchus and lung
type: Class
subclass of: Neoplasm
subclass of: Neoplastic Process

Segmental resection of lung
type: Class
subclass of: Thoracic Surgical Procedure
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: Partial lobectomy
definition: A segment resection removes a larger portion of the lung lobe than a wedge resection, but does not remove the whole lobe.

Lobectomy of Lung
type: Class
subclass of: Thoracic Surgical Procedure
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: Pulmonary lobectomy
definition: A common surgical procedure that removes one lobe of the lung that contains cancerous cells.

Colostomy operation
type: Class
subclass of: Abdominal Surgical Procedure
definition: The surgical creation or closure of an opening between the colon and the surface of the body.

Anterior resection of rectum
type: Class
subclass of: Abdominal Surgical Procedure
subclass of: Therapeutic Surgical Procedure

Permanent
type: Class
subclass of: Temporal Qualifier

Residual tumour status stages
type: Class
subclass of: Finding
see also: EuroCAT Umbrella Protocol for NSCLC
definition: The R classification, an auxiliary classification within the TNM system, denotes the absence or presence of residual tumor after treatment and describes residual tumor as macroscopic or microscopic in amount. The R classification considers residual tumor at the primary tumor siteThe R classification, an auxiliary classification within the TNM system, denotes the absence or presence of residual tumor after treatment and describes residual tumor as macroscopic or microscopic in amount. The R classification considers residual tumor at the primary tumor site, in the regional lymph nodes, and/or at distant sites. As such, it reflects the efficacy of primary treatment, influences the design and institution of additional therapy, and is a strong indicator of prognosis., in the regional lymph nodes, and/or at distant sites. As such, it reflects the efficacy of primary treatment, influences the design and institution of additional therapy, and is a strong indicator of prognosis.

Residual tumour stage RX
type: Class
subclass of: Residual tumour status stages
see also: EuroCAT Umbrella Protocol for NSCLC
definition: The presence of residual tumor cannot be assessed.

Residual tumour stage R0
type: Class
subclass of: Residual tumour status stages
see also: EuroCAT Umbrella Protocol for NSCLC
definition: No residual tumor.

Colostomy - stoma
type: Class
subclass of: Stoma
alternative label: Colostomy
definition: A stoma to the colon.

Construction of temporary colostomy
type: Class
subclass of: Colostomy operation
definition: The surgical creation of a temporary colostomy.

Construction of permanent colostomy
type: Class
subclass of: Colostomy operation
definition: The surgical creation of a permanent colostomy.

Closure of colostomy
type: Class
subclass of: Colostomy operation
definition: The surgical closure of a colostomy.

Residual tumour stage R1
type: Class
subclass of: Residual tumour status stages
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Microscopic residual tumor.

Residual tumour stage R2
type: Class
subclass of: Residual tumour status stages
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Macroscopic residual tumor.

Excision of lesion of rectum
type: Class
subclass of: Abdominal Surgical Procedure
subclass of: Therapeutic Surgical Procedure
definition: Local excision

Saliva sample
type: Class
subclass of: Biospecimen
see also: EuroCAT Umbrella Protocol for NSCLC

Radiotherapy - preoperative control
type: Class
subclass of: Radiation Therapy
subclass of: Neoadjuvant Therapy
definition: The use of radiotherapy prior to the surgical removal of a tumor.

Radiotherapy - postoperative control
type: Class
subclass of: Adjuvant Radiotherapy
definition: A postoperative course of radiotherapy.

Hartmann's procedure
type: Class
subclass of: Abdominal Surgical Procedure
subclass of: Therapeutic Surgical Procedure
definition: Rectosigmoidectomy, closure of rectal stump and exteriorisation of bowel.

Organism
type: Class
subclass of: Physical Object
definition: Generally, a living individual, including all plants and animals.

Plant
type: Class
subclass of: Eukaryote
definition: An organism having cellulose cell walls, growing by synthesis of inorganic substances, generally distinguished by the presence of chlorophyll, and lacking the power of locomotion. Plant parts are included here as well.

Fungus
type: Class
subclass of: Eukaryote
definition: A eukaryotic organism characterized by the absence of chlorophyll and the presence of a rigid cell wall. Included here are both slime molds and true fungi such as yeasts, molds, mildews, and mushrooms.

Virus
type: Class
subclass of: Organism
definition: An organism consisting of a core of a single nucleic acid enclosed in a protective coat of protein. A virus may replicate only inside a host living cell. A virus exhibits some but not all of the usual characteristics of living things.

Bacterium
type: Class
subclass of: Organism
definition: A small, typically one-celled, prokaryotic micro-organism.

Animal
type: Class
subclass of: Eukaryote
definition: An organism with eukaryotic cells, and lacking stiff cell walls, plastids and photosynthetic pigments.

Vertebrate
type: Class
subclass of: Animal
definition: An animal which has a spinal column.

Amphibian
type: Class
subclass of: Vertebrate
definition: A cold-blooded, smooth-skinned vertebrate which characteristically hatches as an aquatic larva, breathing by gills. When mature, the amphibian breathes with lungs.

Bird
type: Class
subclass of: Vertebrate
definition: A vertebrate having a constant body temperature and characterized by the presence of feathers.

Fish
type: Class
subclass of: Vertebrate
definition: A cold-blooded aquatic vertebrate characterized by fins and breathing by gills. Included here are fishes having either a bony skeleton, such as a perch, or a cartilaginous skeleton, such as a shark, or those lacking a jaw, such as a lamprey or hagfish.

Reptile
type: Class
subclass of: Vertebrate
definition: A cold-blooded vertebrate having an external covering of scales or horny plates. Reptiles breathe by means of lungs and are generally egg-laying.

Mammal
type: Class
subclass of: Vertebrate
definition: A vertebrate having a constant body temperature and characterized by the presence of hair, mammary glands and sweat glands.

Human
type: Class
subclass of: Mammal
definition: Modern man, the only remaining species of the Homo genus.

Anatomical Structure
type: Class
subclass of: Physical Object
disjoint with: Organ at Risk (ROI)
definition: A normal or pathological part of the anatomy or structural organization of an organism.

Embryonic Structure
type: Class
subclass of: Anatomical Structure
definition: An anatomical structure that exists only before the organism is fully formed; in mammals, for example, a structure that exists only prior to the birth of the organism. This structure may be normal or abnormal.

Congenital Abnormality
type: Class
subclass of: Anatomical Abnormality
definition: An abnormal structure, or one that is abnormal in size or location, present at birth or evolving over time as a result of a defect in embryogenesis.

Acquired Abnormality
type: Class
subclass of: Anatomical Abnormality
definition: An abnormal structure, or one that is abnormal in size or location, found in or deriving from a previously normal structure. Acquired abnormalities are distinguished from diseases even though they may result in pathological functioning (e.g., hernias incarcerate).

Fully Formed Anatomical Structure
type: Class
subclass of: Anatomical Structure
definition: An anatomical structure in a fully formed organism; in mammals, for example, a structure in the body after the birth of the organism.

Body System
type: Class
subclass of: Functional Concept
definition: A complex of anatomical structures that performs a common function.

Body Part, Organ, or Organ Component
type: Class
subclass of: Fully Formed Anatomical Structure
definition: A collection of cells and tissues which are localized to a specific area or combine and carry out one or more specialized functions of an organism. This ranges from gross structures to small components of complex organs. These structures are relatively localized in comparison to tissues.

Tissue
type: Class
subclass of: Fully Formed Anatomical Structure
definition: An aggregation of similarly specialized cells and the associated intercellular substance. Tissues are relatively non-localized in comparison to body parts, organs or organ components.

Cell
type: Class
subclass of: Fully Formed Anatomical Structure
definition: The fundamental structural and functional unit of living organisms.

Cell Component
type: Class
subclass of: Fully Formed Anatomical Structure
definition: A part of a cell or the intercellular matrix, generally visible by light microscopy.

Gene or Genome
type: Class
subclass of: Fully Formed Anatomical Structure
definition: A specific sequence, or in the case of the genome the complete sequence, of nucleotides along a molecule of DNA or RNA (in the case of some viruses) which represent the functional units of heredity.

Body Location or Region
type: Class
subclass of: Spatial Concept
definition: An area, subdivision, or region of the body demarcated for the purpose of topographical description.

Body Space or Junction
type: Class
subclass of: Spatial Concept
definition: An area enclosed or surrounded by body parts or organs or the place where two anatomical structures meet or connect.

Body Substance
type: Class
subclass of: Substance
definition: Extracellular material, or mixtures of cells and extracellular material, produced, excreted, or accreted by the body. Included here are substances such as saliva, dental enamel, sweat, and gastric acid.

Organism Attribute
type: Class
subclass of: Conceptual Entity
definition: A property of the organism or its major parts.

Finding
type: Class
subclass of: Conceptual Entity
definition: That which is discovered by direct observation or measurement of an organism attribute or condition, including the clinical history of the patient. The history of the presence of a disease is a 'Finding' and is distinguished from the disease itself.

Laboratory or Test Result
type: Class
subclass of: Finding
definition: The outcome of a specific test to measure an attribute or to determine the presence, absence, or degree of a condition.

Injury or Poisoning
type: Class
subclass of: Phenomenon or Process
definition: A traumatic wound, injury, or poisoning caused by an external agent or force.

Biologic Function
type: Class
subclass of: Natural Phenomenon or Process
definition: A state, activity or process of the body or one of its systems or parts.

Physiologic Function
type: Class
subclass of: Biologic Function
definition: A normal process, activity, or state of the body.

Organism Function
type: Class
subclass of: Physiologic Function
definition: A physiologic function of the organism as a whole, of multiple organ systems, or of multiple organs or tissues.

Mental Process
type: Class
subclass of: Organism Function
definition: A physiologic function involving the mind or cognitive processing.

Organ or Tissue Function
type: Class
subclass of: Physiologic Function
definition: A physiologic function of a particular organ, organ system, or tissue.

Cell Function
type: Class
subclass of: Physiologic Function
definition: A physiologic function inherent to cells or cell components.

Molecular Function
type: Class
subclass of: Physiologic Function
definition: A physiologic function occurring at the molecular level.

Genetic Function
type: Class
subclass of: Molecular Function
definition: Functions of or related to the maintenance, translation or expression of the genetic material.

Pathologic Function
type: Class
subclass of: Biologic Function
definition: A disordered process, activity, or state of the organism as a whole, of a body system or systems, or of multiple organs or tissues. Included here are normal responses to a negative stimulus as well as patholologic conditions or states that are less specific than a disease. Pathologic functions frequently have systemic effects.

Disease or Syndrome
type: Class
subclass of: Pathologic Function
definition: A condition which alters or interferes with a normal process, state, or activity of an organism. It is usually characterized by the abnormal functioning of one or more of the host's systems, parts, or organs. Included here is a complex of symptoms descriptive of a disorder.

Mental or Behavioral Dysfunction
type: Class
subclass of: Disease or Syndrome
definition: A clinically significant dysfunction whose major manifestation is behavioral or psychological. These dysfunctions may have identified or presumed biological etiologies or manifestations.

Cell or Molecular Dysfunction
type: Class
subclass of: Pathologic Function
definition: A pathologic function inherent to cells, parts of cells, or molecules.

Experimental Model of Disease
type: Class
subclass of: Pathologic Function
definition: A representation in a non-human organism of a human disease for the purpose of research into its mechanism or treatment.

Event
type: Class
subclass of: Thing
definition: A broad type for grouping activities, processes and states.

Activity
type: Class
subclass of: Event
definition: An operation or series of operations that an organism or machine carries out or participates in.

Behavior
type: Class
subclass of: Activity
definition: Any of the psycho-social activities of humans or animals that can be observed directly by others or can be made systematically observable by the use of special strategies.

Social Behavior
type: Class
subclass of: Behavior
definition: Behavior that is a direct result or function of the interaction of humans or animals with their fellows. This includes behavior that may be considered anti-social.

Individual Behavior
type: Class
subclass of: Behavior
definition: Behavior exhibited by a human or an animal that is not a direct result of interaction with other members of the species, but which may have an effect on others.

Daily or Recreational Activity
type: Class
subclass of: Activity
definition: An activity carried out for recreation or exercise, or as part of daily life.

Occupational Activity
type: Class
subclass of: Activity
definition: An activity carried out as part of an occupation or job.

Health Care Activity
type: Class
subclass of: Occupational Activity
definition: An activity of or relating to the practice of medicine or involving the care of patients.

Laboratory Procedure
type: Class
subclass of: Health Care Activity
definition: A procedure, method, or technique used to determine the composition, quantity, or concentration of a specimen, and which is carried out in a clinical laboratory. Included here are procedures which measure the times and rates of reactions.

Diagnostic Procedure
type: Class
subclass of: Health Care Activity
definition: A procedure, method, or technique used to determine the nature or identity of a disease or disorder. This excludes procedures which are primarily carried out on specimens in a laboratory.

Therapeutic or Preventive Procedure
type: Class
subclass of: Health Care Activity
definition: A procedure, method, or technique designed to prevent a disease or a disorder, or to improve physical function, or used in the process of treating a disease or injury.

Research Activity
type: Class
subclass of: Occupational Activity
definition: An activity carried out as part of research or experimentation.

Molecular Biology Research Technique
type: Class
subclass of: Research Activity
definition: Any of the techniques used in the study of or the directed modification of the gene complement of a living organism.

Governmental or Regulatory Activity
type: Class
subclass of: Occupational Activity
definition: An activity carried out by officially constituted governments, or an activity related to the creation or enforcement of the rules or regulations governing some field of endeavor.

Educational Activity
type: Class
subclass of: Occupational Activity
definition: An activity related to the organization and provision of education.

Machine Activity
type: Class
subclass of: Activity
definition: An activity carried out primarily or exclusively by machines.

Phenomenon or Process
type: Class
subclass of: Event
definition: A process or state which occurs naturally or as a result of an activity.

Human-caused Phenomenon or Process
type: Class
subclass of: Phenomenon or Process
definition: A phenomenon or process that is a result of the activities of human beings.

Environmental Effect of Humans
type: Class
subclass of: Human-caused Phenomenon or Process
definition: A change in the natural environment that is a result of the activities of human beings.

Natural Phenomenon or Process
type: Class
subclass of: Phenomenon or Process
definition: A phenomenon or process that occurs irrespective of the activities of human beings.

Entity
type: Class
subclass of: Thing
definition: A broad type for grouping physical and conceptual entities.

Physical Object
type: Class
subclass of: Entity
definition: An object perceptible to the sense of vision or touch.

Manufactured Object
type: Class
subclass of: Physical Object
definition: A physical object made by human beings.

Medical Device
type: Class
subclass of: Manufactured Object
definition: A manufactured object used primarily in the diagnosis, treatment, or prevention of physiologic or anatomic disorders.

Research Device
type: Class
subclass of: Manufactured Object
definition: A manufactured object used primarily in carrying out scientific research or experimentation.

Conceptual Entity
type: Class
subclass of: Entity
definition: A broad type for grouping abstract entities or concepts.

Idea or Concept
type: Class
subclass of: Conceptual Entity
definition: An abstract concept, such as a social, religious or philosophical concept.

Temporal Concept
type: Class
subclass of: Idea or Concept
definition: A concept which pertains to time or duration.

Qualitative Concept
type: Class
subclass of: Idea or Concept
definition: A concept which is an assessment of some quality, rather than a direct measurement.

Quantitative Concept
type: Class
subclass of: Idea or Concept
definition: A concept which involves the dimensions, quantity or capacity of something using some unit of measure, or which involves the quantitative comparison of entities.

Spatial Concept
type: Class
subclass of: Idea or Concept
definition: A location, region, or space, generally having definite boundaries.

Geographic Area
type: Class
subclass of: Spatial Concept
definition: A geographic location, generally having definite boundaries.

Molecular Sequence
type: Class
subclass of: Spatial Concept
definition: A broad type for grouping the collected sequences of amino acids, carbohydrates, and nucleotide sequences. Descriptions of these sequences are generally reported in the published literature and/or are deposited in and maintained by databanks such as GenBank, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Nucleotide Sequence
type: Class
subclass of: Molecular Sequence
definition: The sequence of purines and pyrimidines in nucleic acids and polynucleotides. Included here are nucleotide-rich regions, conserved sequence, and DNA transforming region.

Amino Acid Sequence
type: Class
subclass of: Molecular Sequence
definition: The sequence of amino acids as arrayed in chains, sheets, etc., within the protein molecule. It is of fundamental importance in determining protein structure.

Carbohydrate Sequence
type: Class
subclass of: Molecular Sequence
definition: The sequence of carbohydrates within polysaccharides, glycoproteins, and glycolipids.

Regulation or Law
type: Class
subclass of: Intellectual Product
definition: An intellectual product resulting from legislative or regulatory activity.

Occupation or Discipline
type: Class
subclass of: Conceptual Entity
definition: A vocation, academic discipline, or field of study, or a subpart of an occupation or discipline.

Biomedical Occupation or Discipline
type: Class
subclass of: Occupation or Discipline
definition: A vocation, academic discipline, or field of study related to biomedicine.

Organization
type: Class
subclass of: Conceptual Entity
definition: The result of uniting for a common purpose or function. The continued existence of an organization is not dependent on any of its members, its location, or particular facility. Components or subparts of organizations are also included here. Although the names of organizations are sometimes used to refer to the buildings in which they reside, they are not inherently physical in nature.

Health Care Related Organization
type: Class
subclass of: Organization
definition: An established organization which carries out specific functions related to health care delivery or research in the life sciences.

Professional Society
type: Class
subclass of: Organization
definition: An organization uniting those who have a common vocation or who are involved with a common field of study.

Self-help or Relief Organization
type: Class
subclass of: Organization
definition: An organization whose purpose and function is to provide assistance to the needy or to offer support to those sharing similar problems.

Group
type: Class
subclass of: Conceptual Entity
definition: A conceptual entity referring to the classification of individuals according to certain shared characteristics.

Professional or Occupational Group
type: Class
subclass of: Group
definition: An individual or individuals classified according to their vocation.

Population Group
type: Class
subclass of: Group
definition: An indivdual or individuals classified according to their sex, racial origin, religion, common place of living, financial or social status, or some other cultural or behavioral attribute.

Family Group
type: Class
subclass of: Group
definition: An individual or individuals classified according to their family relationships or relative position in the family unit.

Age Group
type: Class
subclass of: Group
definition: An individual or individuals classified according to their age.

Patient or Disabled Group
type: Class
subclass of: Group
definition: An individual or individuals classified according to a disability, disease, condition or treatment.

Group Attribute
type: Class
subclass of: Conceptual Entity
definition: A conceptual entity which refers to the frequency or distribution of certain characteristics or phenomena in certain groups.

Chemical
type: Class
subclass of: Substance
definition: Compounds or substances of definite molecular composition. Chemicals are viewed from two distinct perspectives in the network, functionally and structurally. Almost every chemical concept is assigned at least two types, generally one from the structure hierarchy and at least one from the function hierarchy.

Chemical Viewed Structurally
type: Class
subclass of: Chemical
definition: A chemical or chemicals viewed from the perspective of their structural characteristics. Included here are concepts which can mean either a salt, an ion, or a compound (e.g., Bromates and Bromides).

Organic Chemical
type: Class
subclass of: Chemical Viewed Structurally
definition: The general class of carbon-containing compounds, usually based on carbon chains or rings, and also containing hydrogen (hydrocarbons), with or without nitrogen, oxygen, or other elements in which the bonding between elements is generally covalent.

Steroid
type: Class
subclass of: Lipid
definition: One of a group of polycyclic, 17-carbon-atom, fused-ring compounds occurring both in natural and synthetic forms. Included here are naturally occurring and synthetic steroids, bufanolides, cardanolides, homosteroids, norsteroids, and secosteroids.

Eicosanoid
type: Class
subclass of: Lipid
definition: An oxygenated metabolite from polyunsaturated 20 carbon fatty acids including lipoxygenase and cyclooxygenase products and their synthetic analogs. This includes the prostaglandins and thromboxanes.

Nucleic Acid, Nucleoside, or Nucleotide
type: Class
subclass of: Organic Chemical
definition: A complex compound of high molecular weight occurring in living cells. These are basically of two types, ribonucleic (RNA) and deoxyribonucleic (DNA) acids. Nucleic acids are made of nucleotides (nitrogen-containing base, a 5-carbon sugar, and one or more phosphate group) linked together by a phosphodiester bond between the 5' and 3' carbon atoms. Nucleosides are compounds composed of a purine or pyrimidine base (usually adenine, cytosine, guanine, thymine, uracil) linked to either a ribose or a deoxyribose sugar.

Organophosphorus Compound
type: Class
subclass of: Organic Chemical
definition: An organic compound containing phosphorus as a constituent. Included here are organic phosphinic, phosphonic and phosphoric acid derivatives and their thiophosphorus counterparts. Excluded are phospholipids, sugar phosphates, phosphoproteins, nucleotides, and nucleic acids.

Amino Acid, Peptide, or Protein
type: Class
subclass of: Organic Chemical
definition: Amino acids and chains of amino acids connected by peptide linkages.

Carbohydrate
type: Class
subclass of: Organic Chemical
definition: A generic term that includes monosaccharides, oligosaccharides, and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more terminal group to carboxylic acids, or by replacement of one or more hydroxy groups by a hydrogen atom, an amino group, a thiol group or similar heteroatomic groups. It also includes derivatives of these compounds. Included here are sugar phosphates. Excluded are glycolipids and glycoproteins.

Lipid
type: Class
subclass of: Organic Chemical
definition: An inclusive group of fat or fat-derived substances that are soluble in nonpolar solvents related to fatty acid esters, fatty alcohols, sterols, waxes, etc. Included in this group are the saponifiable lipids such as glycerides (fats and oils), essential (volatile) oils, and phospholipids.

Chemical Viewed Functionally
type: Class
subclass of: Chemical
definition: A chemical viewed from the perspective of its functional characteristics or pharmacological activities.

Pharmacologic Substance
type: Class
subclass of: Chemical Viewed Functionally
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A substance used in the treatment or prevention of pathologic disorders. This includes substances that occur naturally in the body and are administered therapeutically.

Biomedical or Dental Material
type: Class
subclass of: Chemical Viewed Functionally
definition: A substance used in biomedicine or dentistry predominantly for its physical, as opposed to chemical, properties. Included here are biocompatible materials, tissue adhesives, bone cements, resins, toothpastes, etc.

Biologically Active Substance
type: Class
subclass of: Chemical Viewed Functionally
definition: A generally endogenous substance produced or required by an organism, of primary interest because of its role in the biologic functioning of the organism that produces it.

Neuroreactive Substance or Biogenic Amine
type: Class
subclass of: Biologically Active Substance
definition: An endogenous substance whose activities affect or play an important role in the functioning of the nervous system. Included here are catecholamines, neuroregulators, neurophysins, etc.

Hormone
type: Class
subclass of: Biologically Active Substance
definition: In animals, a chemical usually secreted by an endocrine gland whose products are released into the circulating fluid. Hormones act as chemical messengers and regulate various physiologic processes such as growth, reproduction, metabolism, etc. They usually fall into two broad classes, steroid hormones and peptide hormones.

Enzyme
type: Class
subclass of: Biologically Active Substance
definition: A complex chemical, usually a protein, that is produced by living cells and which catalyzes specific biochemical reactions. There are six main types of enzymes: oxidoreductases, transferases, hydrolases, lyases, isomerases, and ligases.

Vitamin
type: Class
subclass of: Biologically Active Substance
definition: A substance, usually an organic chemical complex, present in natural products or made synthetically, which is essential in the diet of man or other higher animals. Included here are vitamin precursors, provitamins, and vitamin supplements.

Immunologic Factor
type: Class
subclass of: Biologically Active Substance
definition: A biologically active substance whose activities affect or play a role in the functioning of the immune system.

Indicator, Reagent, or Diagnostic Aid
type: Class
subclass of: Chemical Viewed Functionally
definition: A substance primarily of interest for its use in laboratory or diagnostic tests and procedures to detect, measure, examine, or analyze other chemicals, processes, or conditions.

Hazardous or Poisonous Substance
type: Class
subclass of: Chemical Viewed Functionally
definition: A substance of concern because of its potentially hazardous or toxic effects. This would include most drugs of abuse, as well as agents that require special handling because of their toxicity.

Substance
type: Class
subclass of: Physical Object
definition: A material with definite or fairly definite chemical composition.

Food
type: Class
subclass of: Substance
definition: Any substance generally containing nutrients, such as carbohydrates, proteins, and fats, that can be ingested by a living organism and metabolized into energy and body tissue. Some foods are naturally occurring, others are either partially or entirely made by humans.

Functional Concept
type: Class
subclass of: Idea or Concept
definition: A concept which is of interest because it pertains to the carrying out of a process or activity.

Intellectual Product
type: Class
subclass of: Conceptual Entity
definition: A conceptual entity resulting from human endeavor. Concepts assigned to this type generally refer to information created by humans for some purpose.

Language
type: Class
subclass of: Conceptual Entity
definition: The system of communication used by a particular nation or people.

Sign or Symptom
type: Class
subclass of: Finding
definition: An observable manifestation of a disease or condition based on clinical judgment, or a manifestation of a disease or condition which is experienced by the patient and reported as a subjective observation.

Classification
type: Class
subclass of: Intellectual Product
definition: A term or system of terms denoting an arrangement by class or category.

Anatomical Abnormality
type: Class
subclass of: Anatomical Structure
definition: An abnormal structure, or one that is abnormal in size or location.

Neoplastic Process
type: Class
subclass of: Disease or Syndrome
definition: A new and abnormal growth of tissue in which the growth is uncontrolled and progressive. The growths may be malignant or benign.

Receptor
type: Class
subclass of: Biologically Active Substance
definition: A specific structure or site on the cell surface or within its cytoplasm that recognizes and binds with other specific molecules. These include the proteins on the surface of an immunocompetent cell that binds with antigens, or proteins found on the surface molecules that bind with hormones or neurotransmitters and react with other molecules that respond in a specific way.

Archaeon
type: Class
subclass of: Organism
definition: A member of one of the three domains of life, formerly called Archaebacteria under the taxon Bacteria, but now considered separate and distinct. Archaea are characterized by: 1) the presence of characteristic tRNAs and ribosomal RNAs; 2) the absence of peptidoglycan cell walls; 3) the presence of ether-linked lipids built from branched-chain subunits; and 4) their occurrence in unusual habitats. While archaea resemble bacteria in morphology and genomic organization, they resemble eukarya in their method of genomic replication.

Antibiotic
type: Class
subclass of: Pharmacologic Substance
definition: A pharmacologically active compound produced by growing microorganisms which kill or inhibit growth of other microorganisms.

Element, Ion, or Isotope
type: Class
subclass of: Chemical Viewed Structurally
definition: One of the 109 presently known fundamental substances that comprise all matter at and above the atomic level. This includes elemental metals, rare gases, and most abundant naturally occurring radioactive elements, as well as the ionic counterparts of elements (NA+, Cl-), and the less abundant isotopic forms. This does not include organic ions such as iodoacetate to which the type 'Organic Chemical' is assigned.

Inorganic Chemical
type: Class
subclass of: Chemical Viewed Structurally
definition: Chemical elements and their compounds, excluding the hydrocarbons and their derivatives (except carbides, carbonates, cyanides, cyanates and carbon disulfide). Generally inorganic compounds contain ionic bonds. Included here are inorganic acids and salts, alloys, alkalies, and minerals.

Clinical Drug
type: Class
subclass of: Manufactured Object
definition: A pharmaceutical preparation as produced by the manufacturer. The name usually includes the substance, its strength, and the form, but may include the substance and only one of the other two items.

Clinical Attribute
type: Class
subclass of: Organism Attribute
definition: An observable or measurable property or state of an organism of clinical interest.

Drug Delivery Device
type: Class
subclass of: Medical Device
definition: A medical device that contains a clinical drug or drugs.

Eukaryote
type: Class
subclass of: Organism
definition: One of the three domains of life (the others being Bacteria and Archaea), also called Eukarya. These are organisms whose cells are enclosed in membranes and possess a nucleus. They comprise almost all multicellular and many unicellular organisms, and are traditionally divided into groups (sometimes called kingdoms) including Animals, Plants, Fungi, various Algae, and other taxa that were previously part of the old kingdom Protista.

unit
type: Class
subclass of: Quantitative Concept
definition: A unit of measurement is a standardized quantity of a physical quality.

length unit
type: Class
subclass of: unit
definition: A unit which is a standard measure of the distance between two points.

mass unit
type: Class
subclass of: unit
definition: A unit which is a standard measure of the amount of matter/energy of a physical object.

time unit
type: Class
subclass of: unit
definition: A unit which is a standard measure of the dimension in which events occur in sequence.

kilogram
type: Class
subclass of: mass unit
definition: A mass unit which is equal to the mass of the International Prototype Kilogram kept by the BIPM at Svres, France.

centimeter
type: Class
subclass of: length unit
definition: A length unit which is equal to one hundredth of a meter or 10^[-2] m.

day
type: Class
subclass of: time unit
definition: A time unit which is equal to 24 hours.

month
type: Class
subclass of: time unit
definition: A time unit which is approximately equal to the length of time of one of cycle of the moon's phases which in science is taken to be equal to 30 days.

year
type: Class
subclass of: time unit
definition: A time unit which is equal to 12 months which is science is taken to be equal to 365.25 days.

volume unit
type: Class
subclass of: unit
definition: A unit which is a standard measure of the amount of space occupied by any substance, whether solid, liquid, or gas.

cubic centimeter
type: Class
equivalent class: milliliter
subclass of: volume unit
definition: A volume unit which is equal to one millionth of a cubic meter or 10^[-9] m^[3], or to 1 ml.

milliliter
type: Class
subclass of: volume unit
definition: A volume unit which is equal to one thousandth of a liter or 10^[-3] L, or to 1 cubic centimeter.

Liter
type: Class
subclass of: volume unit
definition: A volume unit which is equal to one millionth of a cubic meter or 10^[-9] m^[3], or to 1 ml.

radiation unit
type: Class
subclass of: unit
definition: A unit which is a standard measure of the amount of radiation emitted by a given radiation source as well as the amount of radiation absorbed or deposited in a specific material by a radiation source.

gray
type: Class
subclass of: radiation unit
definition: An absorbed dose unit which is equal to the absorption of one joule of radiation energy by one kilogram of matter.

percent
type: Class
subclass of: unit
definition: A dimensionless ratio unit which denotes numbers as fractions of 100.

count unit
type: Class
subclass of: unit
definition: A dimensionless unit which denotes a simple count of things.

Interval censored
type: Class
subclass of: Censoring type
definition: The event occurred within an interval, but it is not known exactly when. Example: the last measurement day one person was HIV negative and the first measurement day the person was positive are known, but when the seroconversion happened within that interval is not known

Left censored
type: Class
subclass of: Censoring type
definition: The event occurred some time before the last measurement, but it is not known exactly when. Example: one person tests HIV positive, but there is no negative test result, so it is not possible to estalish a time interval for seroconversion

Censoring type
type: Class
subclass of: Temporal Concept
definition: Censoring type is a particular type of interval creation. Censoring means that one event prevents another event from being observed (e.g., end of study prevents possible evidence of success or failure from being observed). Though usually employed in the context of time-to-failure, this is not only about time, but it can be about any dimension of interest (e.g., if the measurement is above the maximum value in the scale used, then the measurement is right censored; if it is lower than the minimum detectable, then it is left censored).

Right censored
type: Class
subclass of: Censoring type
definition: The event my have occurred some time after the last measurement, but it is not known exactly whether it has, because there are no further observations. Example: one person tests HIV negative at some point, but there are no further observations (e.g., the individual moved, or died), so it is not known whether the person has seroconverted or not

Ninth thoracic vertebra
type: Class
subclass of: Thoracic vertebra

Tenth thoracic vertebra
type: Class
subclass of: Thoracic vertebra

Eleventh thoracic vertebra
type: Class
subclass of: Thoracic vertebra

Twelfth thoracic vertebra
type: Class
subclass of: Thoracic vertebra

Inferior vena cava
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Trunk of systemic vein which is formed by the union of the right common iliac vein and the left common iliac vein and terminates in the right atrium.

Eyeball
type: Class
subclass of: Body Part, Organ, or Organ Component
alternative label: Eye Globe
definition: Organ with organ cavity which is connected to the optic nerve. Examples: There are only two eyeballs, the right and the left eyeballs..

Right eyeball
type: Class
subclass of: Eyeball

Left eyeball
type: Class
subclass of: Eyeball

Atlas
type: Class
subclass of: Cervical vertebra

Axis
type: Class
subclass of: Cervical vertebra

Third cervical vertebra
type: Class
subclass of: Cervical vertebra

Fourth cervical vertebra
type: Class
subclass of: Cervical vertebra

Fifth cervical vertebra
type: Class
subclass of: Cervical vertebra

Sixth cervical vertebra
type: Class
subclass of: Cervical vertebra

Seventh cervical vertebra
type: Class
subclass of: Cervical vertebra

Sacral vertebra
type: Class
subclass of: Body Part, Organ, or Organ Component
alternative label: Sacrum Vertebrae

Esophageal lymph node
type: Class
subclass of: Lymph node
subclass of: Lower zone
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: Station 8 N2 lymph node
alternative label: Station 8 lymph node

First lumbar vertebra
type: Class
subclass of: Lumbar vertebra

Second lumbar vertebra
type: Class
subclass of: Lumbar vertebra

Third lumbar vertebra
type: Class
subclass of: Lumbar vertebra

Fourth lumbar vertebra
type: Class
subclass of: Lumbar vertebra

Fifth lumbar vertebra
type: Class
subclass of: Lumbar vertebra

First sacral vertebra
type: Class
subclass of: Sacral vertebra

Second sacral vertebra
type: Class
subclass of: Sacral vertebra

Third sacral vertebra
type: Class
subclass of: Sacral vertebra

Fourth sacral vertebra
type: Class
subclass of: Sacral vertebra

Fifth sacral vertebra
type: Class
subclass of: Sacral vertebra

Pituitary gland
type: Class
subclass of: Body Part, Organ, or Organ Component
alternative label: Pituitary

Supraclavicular lymph node
type: Class
subclass of: Supraclavicular zone
see also: EuroCAT Umbrella Protocol for NSCLC

Colon
type: Class
subclass of: Body Part, Organ, or Organ Component

Rectum
type: Class
subclass of: Body Part, Organ, or Organ Component

Wall of rectum
type: Class
subclass of: Body Part, Organ, or Organ Component
alternative label: Rectal Wall

Anal canal
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Organ with organ cavity which is continuous proximally with the rectum and distally terminates with the anus. Examples: There is only one anal canal.

Internal anal sphincter
type: Class
subclass of: Anal sphincter

Urinary bladder
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Organ with organ cavity which is continuous proximally with the right and left ureters and distally with the urethra. Examples: There is only one urinary bladder.

Wall of urinary bladder
type: Class
subclass of: Body Part, Organ, or Organ Component

Sacrum
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Bone complex which has as its direct parts five sacral vertebrae.

Bony pelvis
type: Class
subclass of: Body Part, Organ, or Organ Component

Pubic symphysis
type: Class
subclass of: Body Part, Organ, or Organ Component

Uterus
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Organ with organ cavity which is continuous proximally with the right and left uterine tubes and distally is connected to the vagina. Examples: There is only one uterus.

Cervix of uterus
type: Class
subclass of: Body Part, Organ, or Organ Component

Seminal vesicle
type: Class
subclass of: Body Part, Organ, or Organ Component

Right seminal vesicle
type: Class
subclass of: Seminal vesicle

Left seminal vesicle
type: Class
subclass of: Seminal vesicle

Bulb of penis
type: Class
subclass of: Body Part, Organ, or Organ Component
alternative label: Penile Bulb

Urethra
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Organ with organ cavity which connects the cavity of the urinary bladder to the exterior. Examples: There is only one urethra.

Vagina
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Organ with organ cavity which connects the cervical canal of uterus to the vestibule of vagina. Examples: There is only one vagina.

Vulva
type: Class
subclass of: Body Part, Organ, or Organ Component

Parametrium of body of uterus
type: Class
subclass of: Body Part, Organ, or Organ Component

External anal sphincter
type: Class
subclass of: Anal sphincter

Left supraclavicular lymph node
type: Class
subclass of: Supraclavicular lymph node
see also: EuroCAT Umbrella Protocol for NSCLC

Right supraclavicular lymph node
type: Class
subclass of: Supraclavicular lymph node
see also: EuroCAT Umbrella Protocol for NSCLC

Right femur
type: Class
subclass of: Femur

Left femur
type: Class
subclass of: Femur

Glenohumeral joint
type: Class
subclass of: Body Part, Organ, or Organ Component
alternative label: Glenohumeral Joint

Right glenohumeral joint
type: Class
subclass of: Glenohumeral joint

Left glenohumeral joint
type: Class
subclass of: Glenohumeral joint

Bronchial tree
type: Class
subclass of: Body Part, Organ, or Organ Component

Right bronchial tree
type: Class
subclass of: Bronchial tree

Left bronchial tree
type: Class
subclass of: Bronchial tree

Hippocampus
type: Class
subclass of: Body Part, Organ, or Organ Component

Right hippocampus
type: Class
subclass of: Hippocampus

Left hippocampus
type: Class
subclass of: Hippocampus

Aortopulmonary lymph node
type: Class
subclass of: Lymph node
subclass of: AP zone
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: Station 5 N2 lymph node
alternative label: Station 5 lymph node

Para-aortic thoracic lymph node
type: Class
subclass of: Lymph node
subclass of: AP zone
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: Station 6 N2 lymph node
alternative label: Station 6 lymph node

Interlobar lymph node
type: Class
subclass of: Lymph node
subclass of: Hilar/interlobar zone
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: Station 11 N1 lymph node
alternative label: Station 11 lymph node

Lobar lymph node
type: Class
subclass of: Lymph node
subclass of: Peripheral zone
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: Station 12 N1 lymph node
alternative label: Station 12 lymph node

Segmental lymph node
type: Class
subclass of: Lymph node
subclass of: Peripheral zone
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: Station 13 N1 lymph node
alternative label: Station 13 lymph node

Subsegmental lymph node
type: Class
subclass of: Lymph node
subclass of: Peripheral zone
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: Station 14 N1 lymph node
alternative label: Station 14 lymph node

Lymph node of inferior pulmonary ligament
type: Class
subclass of: Lymph node
subclass of: Lower zone
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: Station 9 N2 lymph node
alternative label: Station 9 lymph node

Prevertebral lymph node
type: Class
subclass of: Lymph node
subclass of: Upper zone
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: Station 3P N2 lymph node
alternative label: Station 3P lymph node

Pre-vascular lymph node
type: Class
subclass of: Lymph node
subclass of: Upper zone
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: Station 3A N2 lymph node
alternative label: Station 3A lymph node

Highest mediastinal lymph node
type: Class
subclass of: Lymph node
subclass of: Supraclavicular zone
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: Station 1 N2 lymph node
alternative label: Station 1 lymph node

Right upper paratracheal lymph node
type: Class
subclass of: Lymph node
subclass of: Upper zone
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: Right station 2 N2 lymph node
alternative label: Right station 2 lymph node

Left upper paratracheal lymph node
type: Class
subclass of: Lymph node
subclass of: Upper zone
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: Left station 2 N2 lymph node
alternative label: Left station 2 lymph node

Right breast
type: Class
subclass of: Breast

Left breast
type: Class
subclass of: Breast

Mesorectal lymph node group
type: Class
subclass of: Lymph node group

Hip joint
type: Class
subclass of: Body Part, Organ, or Organ Component
alternative label: Femoral Joint

Right hip joint
type: Class
subclass of: Hip joint

Left hip joint
type: Class
subclass of: Hip joint

Aorta
type: Class
subclass of: Body Part, Organ, or Organ Component

Brachiocephalic artery
type: Class
subclass of: Body Part, Organ, or Organ Component
alternative label: Brachiocephalic Artery

Common carotid artery
type: Class
subclass of: Body Part, Organ, or Organ Component

Right common carotid artery
type: Class
subclass of: Common carotid artery

Subclavian artery
type: Class
subclass of: Body Part, Organ, or Organ Component
alternative label: Subclavicular Artery
definition: Systemic artery the trunk of which is continuous with either the trunk of brachiocephalic artery on the right side, or the aorta on the left side.

Right subclavian artery
type: Class
subclass of: Subclavian artery
definition: Subclavian artery the trunk of which is continuous with trunk of brachiocephalic artery.

Left common carotid artery
type: Class
subclass of: Common carotid artery

Right brachial nerve plexus
type: Class
subclass of: Brachial nerve plexus

Left brachial nerve plexus
type: Class
subclass of: Brachial nerve plexus

Constrictor muscle of pharynx
type: Class
subclass of: Body Part, Organ, or Organ Component

Pharynx
type: Class
subclass of: Body Part, Organ, or Organ Component

Left subclavian artery
type: Class
subclass of: Subclavian artery

Superior vena cava
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Trunk of systemic vein which is formed by the union of the right and left brachiocephalic veins and terminates in the right atrium.

Subclavian vein
type: Class
subclass of: Body Part, Organ, or Organ Component
alternative label: SubClavicular Vein

Right subclavian vein
type: Class
subclass of: Subclavian vein

Left subclavian vein
type: Class
subclass of: Subclavian vein

Azygos vein
type: Class
subclass of: Body Part, Organ, or Organ Component

Masseter
type: Class
subclass of: Body Part, Organ, or Organ Component

Right masseter
type: Class
subclass of: Masseter

Left masseter
type: Class
subclass of: Masseter

Oral cavity proper
type: Class
subclass of: Body Part, Organ, or Organ Component

Inferior hypophysial artery
type: Class
subclass of: Body Part, Organ, or Organ Component

Right inferior hypophyseal artery
type: Class
subclass of: Inferior hypophysial artery

Left inferior hypophyseal artery
type: Class
subclass of: Inferior hypophysial artery

Superior hypophysial artery
type: Class
subclass of: Body Part, Organ, or Organ Component

Right superior hypophyseal artery
type: Class
subclass of: Superior hypophysial artery

Left superior hypophyseal artery
type: Class
subclass of: Superior hypophysial artery

Coronary artery
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Systemic artery which supplies the heart.

Superior pulmonary vein
type: Class
subclass of: Pulmonary vein

Inferior pulmonary vein
type: Class
subclass of: Pulmonary vein

Right inferior pulmonary vein
type: Class
subclass of: Inferior pulmonary vein

Left inferior pulmonary vein
type: Class
subclass of: Inferior pulmonary vein

Right superior pulmonary vein
type: Class
subclass of: Superior pulmonary vein

Left superior pulmonary vein
type: Class
subclass of: Superior pulmonary vein

Right coronary artery
type: Class
subclass of: Coronary artery
definition: Coronary artery which emerges from the anterior aortic sinus, between the right auricle and the pulmonary trunk, and supplies the right side of the heart.

Left coronary artery
type: Class
subclass of: Coronary artery
definition: Coronary artery which emerges from the left posterior aortic sinus, between the left auricle and the pulmonary trunk, and supplies the left side of the heart.

Lymph node
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Organ component of lymphatic tree organ which has as direct regional parts cortex and medulla.

Brain
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Segment of neuraxis which consists of portion of neural tissue organized and subdivided into forebrain, midbrain and hindbrain, contained in cranial cavity and continuous with and rostral to spinal cord.

Optic nerve
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Nerve trunk which is continuous with the retina and the optic chiasm.

Oculomotor nerve
type: Class
subclass of: Cranial nerve
definition: Cranial nerve which connects the midbrain to the extra-ocular and intra-ocular muscles.

Trochlear nerve
type: Class
subclass of: Cranial nerve

Trigeminal nerve
type: Class
subclass of: Cranial nerve

Abducens nerve
type: Class
subclass of: Cranial nerve

Facial nerve
type: Class
subclass of: Cranial nerve
alternative label: Seventh Cranial Nerve

Vestibulocochlear nerve
type: Class
subclass of: Cranial nerve
alternative label: Eighth Cranial Nerve

Glossopharyngeal nerve
type: Class
subclass of: Cranial nerve

Hypoglossal nerve
type: Class
subclass of: Cranial nerve

Right pulmonary artery
type: Class
subclass of: Pulmonary artery

Left pulmonary artery
type: Class
subclass of: Pulmonary artery

Right optic nerve
type: Class
subclass of: Optic nerve
definition: Optic nerve which is continuous with the right retina and the optic chiasm.

Left optic nerve
type: Class
subclass of: Optic nerve
definition: Optic nerve which is continuous with the left retina and the optic chiasm.

Right facial nerve
type: Class
subclass of: Facial nerve

Left facial nerve
type: Class
subclass of: Facial nerve

Right vestibulocochlear nerve
type: Class
subclass of: Vestibulocochlear nerve

Left vestibulocochlear nerve
type: Class
subclass of: Vestibulocochlear nerve

Cauda equina
type: Class
subclass of: Body Part, Organ, or Organ Component

Mandible
type: Class
subclass of: Body Part, Organ, or Organ Component

External ear
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Subdivision of auriculotemporal part of head which has its direct parts pinna and external acoustic tube. Examples: Ther are only two external ears.

Right external ear
type: Class
subclass of: External ear

Left external ear
type: Class
subclass of: External ear

Eye
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Subdivision of face which has as its direct parts orbital cavity and its content and eyelids.

Right eye
type: Class
subclass of: Eye

Left eye
type: Class
subclass of: Eye

Tongue
type: Class
subclass of: Body Part, Organ, or Organ Component

Posterior part of tongue
type: Class
subclass of: Body Part, Organ, or Organ Component
alternative label: Base of tongue

Temporomandibular joint
type: Class
subclass of: Body Part, Organ, or Organ Component
alternative label: Temperomandibular Joint

Right temporomandibular joint
type: Class
subclass of: Temporomandibular joint

Left temporomandibular joint
type: Class
subclass of: Temporomandibular joint

Submandibular gland
type: Class
subclass of: Body Part, Organ, or Organ Component

Larynx
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Heterogeneous cluster that connects the pharynx to the tracheobronchial tree. Examples: There is only one larynx.

Segment of esophagus
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Organ segment which is regional part of esophagus. Examples: cervical part of esophagus, vertebral segment of esophagus.

Glottis
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Subdivision of the larynx which consists of the right and left vocal cords and the rima glottidis. Examples: There is only one glottis.

Middle ear
type: Class
subclass of: Body Part, Organ, or Organ Component

Right middle ear
type: Class
subclass of: Middle ear

Left middle ear
type: Class
subclass of: Middle ear

Vagus nerve
type: Class
subclass of: Cranial nerve

Cornea
type: Class
subclass of: Body Part, Organ, or Organ Component

Right cornea
type: Class
subclass of: Cornea

Left cornea
type: Class
subclass of: Cornea

Lens
type: Class
subclass of: Body Part, Organ, or Organ Component
alternative label: Eye Lens

Right lens
type: Class
subclass of: Lens

Left lens
type: Class
subclass of: Lens

Retina
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Layer of wall of eyeball which is continuous with optic nerve.

Right retina
type: Class
subclass of: Retina
definition: Layer of wall of right eyeball which is continuous with right optic nerve.

Left retina
type: Class
subclass of: Retina
definition: Layer of wall of left eyeball which is continuous with left optic nerve.

Cranial nerve
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Neural tree organ which is continuous with the brain. Examples: Trochlear nerve, facial nerve.

Brachial nerve plexus
type: Class
subclass of: Body Part, Organ, or Organ Component

Lacrimal gland
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Lobular organ the parenchyma of which consists of glandular acini which communicate the lacrimal sac. Examples: There only two, right lacrimal and left lacrimal glands.

Right lacrimal gland
type: Class
subclass of: Lacrimal gland

Left lacrimal gland
type: Class
subclass of: Lacrimal gland

Right superior tracheobronchial lymph node
type: Class
subclass of: Lymph node
subclass of: Upper zone
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: Right station 4 N2 lymph node
alternative label: Right station 4 lymph node

Left superior tracheobronchial lymph node
type: Class
subclass of: Lymph node
subclass of: Upper zone
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: Left station 4 N2 lymph node
alternative label: Left station 4 lymph node

Inferior tracheobronchial lymph node
type: Class
subclass of: Lymph node
subclass of: Subcarinal zone
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: Station 7 N2 lymph node
alternative label: Station 7 lymph node

Bronchopulmonary lymph node
type: Class
subclass of: Lymph node
subclass of: Hilar/interlobar zone
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: Station 10 N1 lymph node
alternative label: Station 10 lymph node

Parotid gland
type: Class
subclass of: Body Part, Organ, or Organ Component
alternative label: Parotid

Right parotid gland
type: Class
subclass of: Parotid gland

Left parotid gland
type: Class
subclass of: Parotid gland

Right submandibular gland
type: Class
subclass of: Submandibular gland

Left submandibular gland
type: Class
subclass of: Submandibular gland

Lip
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Region of labial part of mouth sharing upper or lower boundary of oral orifice.

Cochlea
type: Class
subclass of: Body Part, Organ, or Organ Component

Right cochlea
type: Class
subclass of: Cochlea

Left cochlea
type: Class
subclass of: Cochlea

Cerebral hemisphere
type: Class
subclass of: Body Part, Organ, or Organ Component
alternative label: Cerebrum
definition: Segment of telencephalon which has as its direct proper parts cerebral cortex and cerebral medulla.

Left cerebral hemisphere
type: Class
subclass of: Cerebral hemisphere
definition: Left cerebral hemisphere is one of two bilateral, largely symmetrical organ subdivisions within the telencephalon which contain the cerebral cortex and cerebral white matter.

Frontal lobe
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Frontal lobe is the anterior-most of five lobes of the cerebral hemisphere. It is bounded by the central sulcus on its posterior border and by the longitudinal cerebral fissure on its medial border.

Temporal lobe
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Temporal lobe is the ventrolateral lobe of five lobes comprising each cerebral hemisphere. It is bounded dorsally by the lateral fissure and posteriorly by an arbitrary border shared with the occipital lobe.

Parietal lobe
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Parietal lobe is the one of five lobes of the cerebral hemisphere which occupies the dorsal-posterior portion of the hemisphere. It is bounded by the central sulcus on its anterior border and and by the longitudinal cerebral fissure on its medial border. Posteriorly it shares an arbitrary border with the occipital lobe.

Hypothalamus
type: Class
subclass of: Body Part, Organ, or Organ Component

Optic chiasm
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Nerve trunk which is continuous with right and left optic nerves and right and left optic tracts.

Blood vessel
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Segment of blood vessel tree organ which is a tubular structure the lumen of which contains blood; together with other spatially associated blood vessels constitute blood vessel tree organ.

Pulmonary artery
type: Class
subclass of: Body Part, Organ, or Organ Component

Pulmonary vein
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Vein in the pulmonary vemnous system.

Right cerebral hemisphere
type: Class
subclass of: Cerebral hemisphere
definition: The right cerebral hemisphere is one of two bilateral, largely symmetrical organ subdivisions within the telencephalon which contain the cerebral cortex and cerebral white matter.

Occipital lobe
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Occipital lobe is the one of five lobes of the cerebral hemisphere which occupies the posterior-most portion of the hemisphere. Anteriorly, it shares an arbitrary border with the parietal lobe and temporal lobe. Medially, it is bounded by the longitudinal cerebral fissure.

Cerebellum
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Segment of neuraxis that has as its parts the cerebellar cortex, cerebellar nuclear complex and cerebellar white matter. Examples: There is only one cerebellum.

Lymph node group
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Set of organ components of lymphatic tree organ consisting of lymph nodes without connecting lymphatic vessels.

Heart
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Organ with cavitated organ parts, which is continuous with the systemic and pulmonary arterial and venous trees. Examples: There is only one heart.

Right atrium
type: Class
subclass of: Cardiac atrium
definition: Right cardiac chamber which is continuous with the superior vena cava and inferior vena cava.

Left atrium
type: Class
subclass of: Cardiac atrium
definition: Left cardiac chamber which is continuous with the pulmonary venous trunk.

Right ventricle
type: Class
subclass of: Cardiac ventricle
definition: Right cardiac chamber which is continuous with the pulmonary arterial trunk.

Cardiac atrium
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Cardiac chamber which consists of a wall that surrounds the cavity of an atrium.

Cardiac ventricle
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Cardiac chamber which consists of a wall that surrounds the cavity of a ventricle.

Left ventricle
type: Class
subclass of: Cardiac ventricle
definition: Left cardiac chamber which is continuous with the aorta.

Esophagus
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Organ with organ cavity which is continuous superiorly with the pharynx and inferiorly with the stomach. Examples: There is only one esophagus.

Stomach
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Organ with organ cavity which is continuous proximally with the esophagus and distally with the small intestine. Examples: There is only one stomach.

Skin
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Nonparenchymatous organ that consists of the epidermis, dermis and sets of hair and nails and which surrounds the entire body. Subdivisions of the skin surround various body parts; as a whole, the skin constitutes the external layer of the body. Examples: There is only one skin.

Lung
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Lobular organ which has as its parts alveoli connected to the tracheobronchial tree. Examples: There are only two lungs, right lung and left lung.

Spleen
type: Class
subclass of: Body Part, Organ, or Organ Component

Liver
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Lobular organ which has as its parts lobules connected to the biliary tree. Examples: There is only one liver.

Pancreas
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Lobular organ the parenchyma of which consists of glandular acini which communicate via a duct system with the duodenum. Examples: There is only one pancreas.

Small intestine
type: Class
subclass of: Body Part, Organ, or Organ Component
alternative label: Small Bowel
definition: Organ with organ cavity which is continuous proximally with the stomach and distally with the large intestine. Examples: There is only one small intestine.

Large intestine
type: Class
subclass of: Body Part, Organ, or Organ Component
alternative label: Large Bowel
definition: Organ with organ cavity which is continuous proximally with the small intestine and distally with the anal canal. Examples: There is only large intestine.

Kidney
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Corticomedullary organ which has as its part renal pelvis shared with and connected to ureter. Examples: There are only two, right kidney and left kidney.

Right kidney
type: Class
subclass of: Kidney
definition: Kidney located right of sagittal midplane of body.

Left kidney
type: Class
subclass of: Kidney
definition: Kidney located left of sagittal midplane of body.

Duodenum
type: Class
subclass of: Body Part, Organ, or Organ Component

Ovary
type: Class
subclass of: Body Part, Organ, or Organ Component

Testis
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Lobular organ the parenchyma of which consists of seminiferous tubules which communicate with the duct of the epididymis. Examples: There only two, right testis and left testis.

Right testis
type: Class
subclass of: Testis
definition: Testis located right of sagittal midplane of body.

Left testis
type: Class
subclass of: Testis
definition: Testis located left of sagittal midplane of body.

Right ovary
type: Class
subclass of: Ovary

Left ovary
type: Class
subclass of: Ovary

Right frontal lobe
type: Class
subclass of: Frontal lobe

Left frontal lobe
type: Class
subclass of: Frontal lobe

Right temporal lobe
type: Class
subclass of: Temporal lobe

Left temporal lobe
type: Class
subclass of: Temporal lobe

Right parietal lobe
type: Class
subclass of: Parietal lobe

Left parietal lobe
type: Class
subclass of: Parietal lobe

Right occipital lobe
type: Class
subclass of: Occipital lobe

Left occipital lobe
type: Class
subclass of: Occipital lobe

Right lung
type: Class
subclass of: Lung
definition: Lung located right of sagittal midplane of body and which consists of the right upper lobe, middle lobe and right lower lobe.

Left lung
type: Class
subclass of: Lung
definition: Lung located left of sagittal midplane of body and which consists of the left upper lobe and left lower lobe.

Lobe of lung
type: Class
subclass of: Body Part, Organ, or Organ Component
see also: EuroCAT Umbrella Protocol for NSCLC

Pulmonary hilum
type: Class
subclass of: Body Part, Organ, or Organ Component

Upper lobe of right lung
type: Class
subclass of: Lobe of the Right Lung
subclass of: Upper lobe of lung
see also: EuroCAT Umbrella Protocol for NSCLC

Upper lobe of lung
type: Class
subclass of: Lobe of lung
see also: EuroCAT Umbrella Protocol for NSCLC

Lower lobe of lung
type: Class
subclass of: Lobe of lung
see also: EuroCAT Umbrella Protocol for NSCLC

Lower lobe of right lung
type: Class
subclass of: Lobe of the Right Lung
subclass of: Lower lobe of lung
see also: EuroCAT Umbrella Protocol for NSCLC

Upper lobe of left lung
type: Class
subclass of: Lobe of the Left Lung
subclass of: Upper lobe of lung
subclass of: Both Lobes of the Left Lung
see also: EuroCAT Umbrella Protocol for NSCLC

Lower lobe of left lung
type: Class
subclass of: Lobe of the Left Lung
subclass of: Lower lobe of lung
subclass of: Both Lobes of the Left Lung
see also: EuroCAT Umbrella Protocol for NSCLC

Middle lobe of right lung
type: Class
subclass of: Lobe of the Right Lung
see also: EuroCAT Umbrella Protocol for NSCLC

Trachea
type: Class
subclass of: Body Part, Organ, or Organ Component

Right main bronchus
type: Class
subclass of: Main bronchus

Left main bronchus
type: Class
subclass of: Main bronchus

Main bronchus
type: Class
subclass of: Body Part, Organ, or Organ Component

Lingula of left lung
type: Class
subclass of: Body Part, Organ, or Organ Component

Right pulmonary hilum
type: Class
subclass of: Pulmonary hilum

Carina of trachea
type: Class
subclass of: Body Part, Organ, or Organ Component

Rib cage
type: Class
subclass of: Body Part, Organ, or Organ Component

Rib
type: Class
subclass of: Body Part, Organ, or Organ Component

True rib
type: Class
subclass of: Rib

Typical rib
type: Class
subclass of: True rib

False rib
type: Class
subclass of: Rib

Floating rib
type: Class
subclass of: False rib

Atypical rib
type: Class
subclass of: True rib

First rib
type: Class
subclass of: Atypical rib

Second rib
type: Class
subclass of: Atypical rib

Third rib
type: Class
subclass of: Typical rib

Spinal cord
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Segment of neuraxis which consists of portion of neural tissue continuous with and caudal to brain, surround central canal and contained in space of vertebral canal.

Fourth rib
type: Class
subclass of: Typical rib

Fifth rib
type: Class
subclass of: Typical rib

Seventh rib
type: Class
subclass of: Typical rib

Right first rib
type: Class
subclass of: First rib

Right second rib
type: Class
subclass of: Second rib

Right third rib
type: Class
subclass of: Third rib

Right fourth rib
type: Class
subclass of: Fourth rib

Left first rib
type: Class
subclass of: First rib

Brainstem
type: Class
subclass of: Body Part, Organ, or Organ Component

Left second rib
type: Class
subclass of: Second rib

Left third rib
type: Class
subclass of: Third rib

Right fifth rib
type: Class
subclass of: Fifth rib

Left fifth rib
type: Class
subclass of: Fifth rib

Eighth rib
type: Class
subclass of: False rib

Sixth rib
type: Class
subclass of: Typical rib

Left fourth rib
type: Class
subclass of: Fourth rib

Right sixth rib
type: Class
subclass of: Sixth rib

Left sixth rib
type: Class
subclass of: Sixth rib

Right seventh rib
type: Class
subclass of: Seventh rib

Left seventh rib
type: Class
subclass of: Seventh rib

Right eighth rib
type: Class
subclass of: Eighth rib

Left eighth rib
type: Class
subclass of: Eighth rib

Ninth rib
type: Class
subclass of: False rib

Right ninth rib
type: Class
subclass of: Ninth rib

Left ninth rib
type: Class
subclass of: Ninth rib

Tenth rib
type: Class
subclass of: False rib

Right tenth rib
type: Class
subclass of: Tenth rib

Left tenth rib
type: Class
subclass of: Tenth rib

Eleventh rib
type: Class
subclass of: Floating rib

Twelfth rib
type: Class
subclass of: Floating rib

Right eleventh rib
type: Class
subclass of: Eleventh rib

Left eleventh rib
type: Class
subclass of: Eleventh rib

Right twelfth rib
type: Class
subclass of: Twelfth rib

Left twelfth rib
type: Class
subclass of: Twelfth rib

Thoracic vertebra
type: Class
subclass of: Body Part, Organ, or Organ Component

First thoracic vertebra
type: Class
subclass of: Thoracic vertebra

Second thoracic vertebra
type: Class
subclass of: Thoracic vertebra

Third thoracic vertebra
type: Class
subclass of: Thoracic vertebra

Fourth thoracic vertebra
type: Class
subclass of: Thoracic vertebra

Perineum
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Subdivision of trunk proper, which is demarcated from the pelvis by the inferior surface of the pelvic diaphragm and from the lower limbs by the perineofemoral lines; together with the thorax, and abdomen, it constitutes the trunk proper. Examples: There is only one perineum.

Salivary gland
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Lobular organ the parenchyma of which consists of glandular acini which communicate with oral cavity. Examples: parotid gland, sublingual gland, lingual salivary gland.

Prostate
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Lobular organ the parenchyma of which has as its parts glandular acini which are continuous with the prostatic part of the urethra. Examples: There is only one prostate.

Breast
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Region of pectoral part of chest which has as its parts nipple, areola, breast proper.

Thyroid gland
type: Class
subclass of: Body Part, Organ, or Organ Component
alternative label: Thyroid
definition: Lobular organ the parenchyma of which consists of ductless, glandular follicles filled with colloid. Examples: thyroid gland proper, accessory thyroid gland, lingual thyroid gland.

Femur
type: Class
subclass of: Body Part, Organ, or Organ Component

Penis
type: Class
subclass of: Body Part, Organ, or Organ Component

Left pulmonary hilum
type: Class
subclass of: Pulmonary hilum

Mediastinum
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Subdivsion of thoracic compartment which has as its parts the superior mediastinum and inferior mediastinum.

Pericardium
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Organ cluster which has as its direct parts the fibrous pericardium and the pericardial sac.

Cervical vertebra
type: Class
subclass of: Body Part, Organ, or Organ Component

Lumbar vertebra
type: Class
subclass of: Body Part, Organ, or Organ Component

Fifth thoracic vertebra
type: Class
subclass of: Thoracic vertebra

Sixth thoracic vertebra
type: Class
subclass of: Thoracic vertebra

Seventh thoracic vertebra
type: Class
subclass of: Thoracic vertebra

Eighth thoracic vertebra
type: Class
subclass of: Thoracic vertebra

InformationEntity
type: Class
subclass of: DICOM Functional Concept

InformationObjectDefinition
type: Class
subclass of: DICOM Functional Concept
definition: An Information Object Definition (IOD) is an object-oriented abstract data model used to specify information about Real-World Objects. An IOD provides communicating Application Entities with a common view of the information to be exchanged. (DICOM)

Patient
type: Class
subclass of: InformationEntity

RTDose
type: Class
subclass of: InformationObjectDefinition

RTImage
type: Class
subclass of: InformationObjectDefinition

RTPlan
type: Class
subclass of: InformationObjectDefinition

RTStructureSet
type: Class
subclass of: InformationObjectDefinition

Series
type: Class
subclass of: InformationEntity

Study
type: Class
subclass of: InformationEntity

Two or More Years Survival
type: Class
subclass of: Survival
creator: Andre Dekker
definition: Elapsed time two or more years that a person has been alive since a related observation, procedure, event or finding.

Less Than Two Years Survival
type: Class
subclass of: Survival
creator: Andre Dekker
definition: Elapsed time is less than two years that a person has been alive since a related observation, procedure, event or finding. The person has died.

Adult comorbidity evaluation-27
type: Class
subclass of: Finding
creator: Andre Dekker
definition: The Adult Comorbidity Evaluation - 27 is a 27-item comorbidity index for patients with cancer. It identifies the important medical comorbidities and grades severity using the index. For more information: https://www.rtog.org/LinkClick.aspx?fileticket=xMGEfaLHRuM%3D&tabid=290.

'Age at Diagnosis'
type: Class
subclass of: Age
creator: Andre Dekker
label: Age at Diagnosis
definition: Age at the time of diagnosis of the disease.

Age at Start RT
type: Class
subclass of: Age
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: The age of the patient at the start of radiotherapy.

GTV (ROI)
type: Class
subclass of: Target Volume (ROI)
subclass of: Class
  intersection of: Target Volume (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Gross Tumor Volume
creator: Andre Dekker
definition: A region of interest based on a delineation of the Gross Tumor Volume. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

PTV (ROI)
type: Class
subclass of: Target Volume (ROI)
subclass of: Class
  intersection of: Target Volume (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Planning Target Volume - Primary Tumor
creator: Andre Dekker
definition: A region of interest based on a delineation of the Planning Target Volume. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

SUVmax
type: Class
subclass of: Standardized Uptake Value
creator: Andre Dekker
definition: The maximum tracer uptake in a given region of interest calculated standardized using the bdy weight and the injected activity.

SUVmean
type: Class
subclass of: Standardized Uptake Value
creator: Andre Dekker
definition: The mean tracer uptake in a given region of interest calculated standardized using the bdy weight and the injected activity.

Delivered Radiotherapy Total Treatment Dose
type: Class
subclass of: Delivered Radiation Dose
subclass of: Radiotherapy Total Treatment Dose
creator: Andre Dekker
definition: The total absorbed radiation dose delivered to a tumor in a complete radiotherapy treatment.

Delivered Radiation Dose
type: Class
subclass of: Absorbed Radiation Dose
creator: Andre Dekker
definition: The absorbed radiation dose actually delivered to a tissue.

Prescribed Radiation Dose
type: Class
subclass of: Absorbed Radiation Dose
creator: Andre Dekker
definition: The absorbed radiation dose prescribed to be delivered to a tissue.

Survival
type: Class
subclass of: Elapsed Time
creator: Andre Dekker
definition: Elapsed time that a person has been alive since a related observation, procedure, event or finding.

Sequential Chemoradiotherapy
type: Class
subclass of: Radiation Therapy
subclass of: Chemoradiotherapy
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Chemotherapy given before and/or after radiotherapy.

Living with partner
type: Class
subclass of: Social Circumstances
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: The social circumstance where a persons lives with a partner in a romantic relantionship.

Cause of death related to cancer
type: Class
subclass of: Cause of Death
disjoint with: Cause of death not related to cancer
creator: Andre Dekker
definition: The circumstance or condition that resulted in the death of a living being was related to cancer.

Cause of death directly related to cancer
type: Class
subclass of: Cause of death related to cancer
creator: Andre Dekker
definition: The circumstance or condition that resulted in the death of a living being was directly related to cancer. An example is death due to respiratory failure cause by metastases in the lung.

Cause of death indirectly related to cancer
type: Class
subclass of: Cause of death related to cancer
creator: Andre Dekker
definition: The circumstance or condition that resulted in the death of a living being was directly related to cancer. An example is death due to respiratory failure cause by radiation pneuomnitis after lung cancer radiotherapy.

Cause of death not related to cancer
type: Class
subclass of: Cause of Death
creator: Andre Dekker
definition: The circumstance or condition that resulted in the death of a living being was not related to cancer.

Positive Lymph Node Stations
type: Class
subclass of: Count
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Number of positive lymph node stations (PLNS), assessed by FDG-PET scan, using the Naruke map.

Number of Images
type: Class
subclass of: Count
creator: Andre Dekker
definition: The count of images in a given image set.

AJCC Edition
type: Class
subclass of: Version
creator: Andre Dekker
definition: Edition of the American Joint Commission on Cancer (AJCC) Cancer Staging Manual.

AJCC 7th Edition
type: Class
subclass of: AJCC Edition
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Seventh edition of the American Joint Commission on Cancer (AJCC) Cancer Staging Manual.

AJCC 6th Edition
type: Class
subclass of: AJCC Edition
creator: Andre Dekker
definition: Sixth edition of the American Joint Commission on Cancer (AJCC) Cancer Staging Manual.

Volume of the Primary Tumor
type: Class
subclass of: Tumor Volume
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: The volume of the primary tumor.

Volume of the Positive Macroscopic Nodes
type: Class
subclass of: Tumor Volume
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: The total volume of all macroscopic lymph nodes metastases in the body.

Radiotherapy Fraction
type: Class
subclass of: Therapeutic Procedure
creator: Andre Dekker
definition: A therapeutic procedure or session in which part of the full radiotherapy course is delivered. Commonly radiotherapy is given in daily fractions. This allows healthy cells to recover between fractions.

Prescribed Radiotherapy Total Treatment Dose
type: Class
subclass of: Prescribed Radiation Dose
subclass of: Radiotherapy Total Treatment Dose
creator: Andre Dekker
definition: The total absorbed radiation dose prescribed to a tumor in a complete radiotherapy treatment.

First Radiotherapy fraction
type: Class
subclass of: Radiotherapy Fraction
creator: Andre Dekker
definition: The first fraction of a radiotherapy treatment.

Last Radiotherapy fraction
type: Class
subclass of: Radiotherapy Fraction
creator: Andre Dekker
definition: The last fraction of a radiotherapy treatment.

Person Identifier
type: Class
subclass of: Identifier
creator: Andre Dekker
definition: An identifier which is used to uniquely identify a person in a certain context (cohort, hospital, trial). Can be a pseudonym.

Living alone
type: Class
subclass of: Social Circumstances
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: The social circumstance where a persons lives alone.

Survival Time Since First Treatment
type: Class
subclass of: Elapsed Time
creator: Andre Dekker
definition: Time elapsed between time of fist treatment and the patient's time of death.

Multiple Lobes of the Lung
type: Class
subclass of: Body Part, Organ, or Organ Component
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: An area in the body consisting of more than one lung lobe. E.g. a lung cancer may have grown into multiple lobes of the lung.

Non-Thoracic Secondary Neoplasm
type: Class
subclass of: Secondary Neoplasm
creator: Andre Dekker
definition: A secondary neoplasm which is not found in the thorax.

Thoracic Secondary Neoplasm
type: Class
subclass of: Secondary Neoplasm
creator: Andre Dekker
definition: A secondary neoplasm which is found in the thorax.

Radiation Oncology Region of Interest
type: Class
subclass of: Imaging Region of Interest
creator: Andre Dekker
definition: The class of regions of interest used in Radiation Oncology and adhering to the Standardized Naming Conventions in Radiation Oncology.

Target Volume (ROI)
type: Class
subclass of: Radiation Oncology Region of Interest
creator: Andre Dekker
definition: A region of interest based on a delineation of a Target Volume.

Organ at Risk (ROI)
type: Class
subclass of: Class
  intersection of: Radiation Oncology Region of Interest
  intersection of: Restriction
    on property: delineation_of
    some values from: Organ at Risk
creator: Andre Dekker
definition: A region of interest based on a delineation of an Organ-At-Risk (OAR).

Concurrent Chemoradiotherapy
type: Class
subclass of: Radiation Therapy
subclass of: Chemoradiotherapy
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: Concomitant Chemoradiotheraoy
definition: Chemotherapy administered during radiotherapy.

Radiotherapy Margin
type: Class
subclass of: Margin
creator: Andre Dekker
definition: A radiotherapy margin provides a buffer in the delineation of tissues to account for uncertainties. (ICRU 83)

Nonuniform Margin
type: Class
subclass of: Radiotherapy Margin
creator: Andre Dekker
definition: A radiotherapy margin which is not the same in all directions.

Uniform Margin
type: Class
subclass of: Radiotherapy Margin
creator: Andre Dekker
definition: A radiotherapy margin which is the same in all directions.

Tumor Length
type: Class
subclass of: Length
creator: Andre Dekker
definition: A one-dimensional size determination of the tumor along the length axis. Typically tumors in elongated organs (e.g. esophagus, rectum) are measured along the long axis of the organ rather than the traverse or other axes.

AnalCanal (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Anal canal
creator: Andre Dekker
definition: A region of interest based on a delineation of the anal canal as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Kidney_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left kidney
creator: Andre Dekker
definition: A region of interest based on a delineation of the left kidney as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Kidney_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right kidney
creator: Andre Dekker
definition: A region of interest based on a delineation of the right kidney as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

MainBronchus_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left main bronchus
creator: Andre Dekker
definition: A region of interest based on a delineation of the left main bronchus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

A_Pulmonary (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Pulmonary artery
creator: Andre Dekker
definition: A region of interest based on a delineation of the pulmonary artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

A_Carotid (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Common carotid artery
creator: Andre Dekker
definition: A region of interest based on a delineation of the common carotid artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

A_Brachiocephali (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Brachiocephalic artery
creator: Andre Dekker
definition: A region of interest based on a delineation of the brachiocephalic artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

A_Coronary (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Coronary artery
creator: Andre Dekker
definition: A region of interest based on a delineation of the coronary artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

A_Subclavicular (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Subclavian artery
creator: Andre Dekker
definition: A region of interest based on a delineation of the subclavian artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

A_HypophysealSuperior (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Superior hypophysial artery
creator: Andre Dekker
definition: A region of interest based on a delineation of the superior hypophysial artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Aorta (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Aorta
creator: Andre Dekker
definition: A region of interest based on a delineation of the aorta as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

AnalSphincter (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Anal sphincter
creator: Andre Dekker
definition: A region of interest based on a delineation of the anal sphincter as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Atrium (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Cardiac atrium
creator: Andre Dekker
definition: A region of interest based on a delineation of the cardiac atrium as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Bladder (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Urinary bladder
creator: Andre Dekker
definition: A region of interest based on a delineation of the urinary bladder as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

BladderWall (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Wall of urinary bladder
creator: Andre Dekker
definition: A region of interest based on a delineation of the wall of urinary bladder as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

BrachialPlexus (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Brachial nerve plexus
creator: Andre Dekker
definition: A region of interest based on a delineation of the brachial nerve plexus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Brain (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Brain
creator: Andre Dekker
definition: A region of interest based on a delineation of the brain as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

BrainStem (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Brainstem
creator: Andre Dekker
definition: A region of interest based on a delineation of the brainstem as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Breast (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Breast
creator: Andre Dekker
definition: A region of interest based on a delineation of the breast as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

BronchialTree (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Bronchial tree
creator: Andre Dekker
definition: A region of interest based on a delineation of the bronchial tree as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

BaseOfTongue (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Posterior part of tongue
creator: Andre Dekker
definition: A region of interest based on a delineation of the posterior part of tongue as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Carina (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Carina of trachea
creator: Andre Dekker
definition: A region of interest based on a delineation of the carina of trachea as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

CaudaEquina (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Cauda equina
creator: Andre Dekker
definition: A region of interest based on a delineation of the cauda equina as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Cerebellum (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Cerebellum
creator: Andre Dekker
definition: A region of interest based on a delineation of the cerebellum as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Cerebrum (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Cerebral hemisphere
creator: Andre Dekker
definition: A region of interest based on a delineation of the cerebral hemisphere as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Chiasm (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Optic chiasm
creator: Andre Dekker
definition: A region of interest based on a delineation of the optic chiasm as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

CN_VII (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Facial nerve
creator: Andre Dekker
definition: A region of interest based on a delineation of the facial nerve as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

CN_VIII (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Vestibulocochlear nerve
creator: Andre Dekker
definition: A region of interest based on a delineation of the vestibulocochlear nerve as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Cervix (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Cervix of uterus
creator: Andre Dekker
definition: A region of interest based on a delineation of the cervix of uterus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Cochlea (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Cochlea
creator: Andre Dekker
definition: A region of interest based on a delineation of the cochlea as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Colon (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Colon
creator: Andre Dekker
definition: A region of interest based on a delineation of the colon as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

ConstrMuscle (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Constrictor muscle of pharynx
creator: Andre Dekker
definition: A region of interest based on a delineation of the constrictor muscle of pharynx as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Cornea (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Cornea
creator: Andre Dekker
definition: A region of interest based on a delineation of the cornea as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Duodenum (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Duodenum
creator: Andre Dekker
definition: A region of interest based on a delineation of the duodenum as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Ear_Middle (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Middle ear
creator: Andre Dekker
definition: A region of interest based on a delineation of the middle ear as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Ear_External (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: External ear
creator: Andre Dekker
definition: A region of interest based on a delineation of the external ear as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Esophagus (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Esophagus
creator: Andre Dekker
definition: A region of interest based on a delineation of the esophagus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Esophagus_Upper (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Upper Third of the Esophagus
creator: Andre Dekker
definition: A region of interest based on a delineation of the upper third of the esophagus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Esophagus_Lower (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Lower Third of the Esophagus
creator: Andre Dekker
definition: A region of interest based on a delineation of the lower third of the esophagus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Esophagus_Middle (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Middle Third of the Esophagus
creator: Andre Dekker
definition: A region of interest based on a delineation of the middle third of the esophagus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

External (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Skin
creator: Andre Dekker
definition: A region of interest based on a delineation of the skin as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Eye (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Eye
creator: Andre Dekker
definition: A region of interest based on a delineation of the eye as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Femur (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Femur
creator: Andre Dekker
definition: A region of interest based on a delineation of the femur as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

FemoralJoint (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Hip joint
creator: Andre Dekker
definition: A region of interest based on a delineation of the hip joint as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

FrontalLobe (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Frontal lobe
creator: Andre Dekker
definition: A region of interest based on a delineation of the frontal lobe as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

GHJoint (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Glenohumeral joint
creator: Andre Dekker
definition: A region of interest based on a delineation of the glenohumeral joint as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Globe (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Eyeball
creator: Andre Dekker
definition: A region of interest based on a delineation of the eyeball as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Glottis (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Glottis
creator: Andre Dekker
definition: A region of interest based on a delineation of the glottis as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

GreatVessel (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Great Blood Vessel
creator: Andre Dekker
definition: A region of interest based on a delineation of the great blood vessel as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Heart (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Heart
creator: Andre Dekker
definition: A region of interest based on a delineation of the heart as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Hippocampus (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Hippocampus
creator: Andre Dekker
definition: A region of interest based on a delineation of the hippocampus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Hypothalamus (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Hypothalamus
creator: Andre Dekker
definition: A region of interest based on a delineation of the hypothalamus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Kidney (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Kidney
creator: Andre Dekker
definition: A region of interest based on a delineation of the kidney as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

LargeBowel (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Large intestine
creator: Andre Dekker
definition: A region of interest based on a delineation of the large intestine as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Larynx (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Larynx
creator: Andre Dekker
definition: A region of interest based on a delineation of the larynx as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

LacrimalGland (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Lacrimal gland
creator: Andre Dekker
definition: A region of interest based on a delineation of the lacrimal gland as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Lens (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Lens
creator: Andre Dekker
definition: A region of interest based on a delineation of the lens as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Lips (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Lip
creator: Andre Dekker
definition: A region of interest based on a delineation of the lip as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Liver (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Liver
creator: Andre Dekker
definition: A region of interest based on a delineation of the liver as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Lung (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Lung
creator: Andre Dekker
definition: A region of interest based on a delineation of the lung as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Mandible (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Mandible
creator: Andre Dekker
definition: A region of interest based on a delineation of the mandible as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

MassMuscle (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Masseter
creator: Andre Dekker
definition: A region of interest based on a delineation of the masseter as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Mediastinum (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Mediastinum
creator: Andre Dekker
definition: A region of interest based on a delineation of the mediastinum as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

MainBronchus (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Main bronchus
creator: Andre Dekker
definition: A region of interest based on a delineation of the main bronchus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

OccipitalLobe (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Occipital lobe
creator: Andre Dekker
definition: A region of interest based on a delineation of the occipital lobe as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

OpticNerve (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Optic nerve
creator: Andre Dekker
definition: A region of interest based on a delineation of the optic nerve as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

OralCavity (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Oral cavity proper
creator: Andre Dekker
definition: A region of interest based on a delineation of the oral cavity proper as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Ovary (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Ovary
creator: Andre Dekker
definition: A region of interest based on a delineation of the ovary as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Parametrium (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Parametrium of body of uterus
creator: Andre Dekker
definition: A region of interest based on a delineation of the parametrium of body of uterus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

ParietalLobe (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Parietal lobe
creator: Andre Dekker
definition: A region of interest based on a delineation of the parietal lobe as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Pancreas (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Pancreas
creator: Andre Dekker
definition: A region of interest based on a delineation of the pancreas as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Parotid (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Parotid gland
creator: Andre Dekker
definition: A region of interest based on a delineation of the parotid gland as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

PelvicBones (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Bony pelvis
creator: Andre Dekker
definition: A region of interest based on a delineation of the bony pelvis as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

PenileBulb (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Bulb of penis
creator: Andre Dekker
definition: A region of interest based on a delineation of the bulb of penis as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Penis (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Penis
creator: Andre Dekker
definition: A region of interest based on a delineation of the penis as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Perineum (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Perineum
creator: Andre Dekker
definition: A region of interest based on a delineation of the perineum as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Pericardium (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Pericardium
creator: Andre Dekker
definition: A region of interest based on a delineation of the pericardium as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Pharynx (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Pharynx
creator: Andre Dekker
definition: A region of interest based on a delineation of the pharynx as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

PharynxConst (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Constrictor muscle of pharynx
creator: Andre Dekker
definition: A region of interest based on a delineation of the constrictor muscle of pharynx as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Pituitary (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Pituitary gland
creator: Andre Dekker
definition: A region of interest based on a delineation of the pituitary gland as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Prostate (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Prostate
creator: Andre Dekker
definition: A region of interest based on a delineation of the prostate as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

PubicSymphysis (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Pubic symphysis
creator: Andre Dekker
definition: A region of interest based on a delineation of the pubic symphysis as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Rectum (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Rectum
creator: Andre Dekker
definition: A region of interest based on a delineation of the rectum as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

RectalWall (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Wall of rectum
creator: Andre Dekker
definition: A region of interest based on a delineation of the wall of rectum as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Retina (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Retina
creator: Andre Dekker
definition: A region of interest based on a delineation of the retina as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Rib (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Rib
creator: Andre Dekker
definition: A region of interest based on a delineation of the rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Sacrum (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Sacrum
creator: Andre Dekker
definition: A region of interest based on a delineation of the sacrum as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

SalivaryGland (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Salivary gland
creator: Andre Dekker
definition: A region of interest based on a delineation of the salivary gland as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

SeminalVesicle (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Seminal vesicle
creator: Andre Dekker
definition: A region of interest based on a delineation of the seminal vesicle as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

SmallBowel (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Small intestine
creator: Andre Dekker
definition: A region of interest based on a delineation of the small intestine as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

SpinalCord (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Spinal cord
creator: Andre Dekker
definition: A region of interest based on a delineation of the spinal cord as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Spleen (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Spleen
creator: Andre Dekker
definition: A region of interest based on a delineation of the spleen as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Stomach (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Stomach
creator: Andre Dekker
definition: A region of interest based on a delineation of the stomach as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Submandibular (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Submandibular gland
creator: Andre Dekker
definition: A region of interest based on a delineation of the submandibular gland as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Supertentorial (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Supratentorial Brain
creator: Andre Dekker
definition: A region of interest based on a delineation of the supratentorial brain as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

TemporalLobe (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Temporal lobe
creator: Andre Dekker
definition: A region of interest based on a delineation of the temporal lobe as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Testis (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Testis
creator: Andre Dekker
definition: A region of interest based on a delineation of the testis as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Thyroid (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Thyroid gland
creator: Andre Dekker
definition: A region of interest based on a delineation of the thyroid gland as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

TMjoint (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Temporomandibular joint
creator: Andre Dekker
definition: A region of interest based on a delineation of the temporomandibular joint as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Trachea (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Trachea
creator: Andre Dekker
definition: A region of interest based on a delineation of the trachea as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Tongue (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Tongue
creator: Andre Dekker
definition: A region of interest based on a delineation of the tongue as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Urethra (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Urethra
creator: Andre Dekker
definition: A region of interest based on a delineation of the urethra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Uterus (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Uterus
creator: Andre Dekker
definition: A region of interest based on a delineation of the uterus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

V_Azygos (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Azygos vein
creator: Andre Dekker
definition: A region of interest based on a delineation of the azygos vein as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

V_CavaInferior (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Inferior vena cava
creator: Andre Dekker
definition: A region of interest based on a delineation of the inferior vena cava as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

V_CavaSuperior (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Superior vena cava
creator: Andre Dekker
definition: A region of interest based on a delineation of the superior vena cava as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

V_Pulmonary (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Pulmonary vein
creator: Andre Dekker
definition: A region of interest based on a delineation of the pulmonary vein as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

V_SubClav (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Subclavian vein
creator: Andre Dekker
definition: A region of interest based on a delineation of the subclavian vein as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Vagina (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Vagina
creator: Andre Dekker
definition: A region of interest based on a delineation of the vagina as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_Cervical (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Cervical vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the cervical vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_Thoracic (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Thoracic vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the thoracic vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_Lumbar (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Lumbar vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the lumbar vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_Sacrum (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Sacral vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the sacral vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Ventricle (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Cardiac ventricle
creator: Andre Dekker
definition: A region of interest based on a delineation of the cardiac ventricle as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Vessels (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Blood vessel
creator: Andre Dekker
definition: A region of interest based on a delineation of the blood vessel as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Vulva (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Vulva
creator: Andre Dekker
definition: A region of interest based on a delineation of the vulva as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Living with children
type: Class
subclass of: Social Circumstances
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: The social circumstance where a persons lives with one of more of their children.

Living with partner and children
type: Class
subclass of: Class
  intersection of: Living with partner
  intersection of: Living with children
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: The social circumstance where a persons lives with one of more of their children and a partner.

Positive Mediastinal Lymph Node Stations
type: Class
subclass of: Count
creator: Andre Dekker
definition: Number of positive lymph node stations (PLNS), assessed by FDG-PET scan, using the Naruke map using only mediastinal stations (excluding stations 10-14).

Quantity
type: Class
subclass of: Quantitative Concept
creator: Andre Dekker
definition: An abstract concept which is any specification of how many or how much of something there is.

Unimodality Therapy
type: Class
subclass of: Therapeutic or Preventive Procedure
creator: Andre Dekker
definition: Use of one treatment modalities; e.g., surgery or radiation or chemotherapy. Can refer to use of two or more chemotherapeutic agents. Can refer to use of two or more radiotherapy modalities (e.g. a combination of brachytherapy and teletherapy).

Lymph Node by Zone and Station
type: Class
subclass of: Lymph node
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Lymph nodes classified in zones and stations according to lymph node map of the AJCC 7th edition of the TNM classification for lung cancer. For prognostic purposes, thoracic lymph nodes can be divided into prognostic zones which is easier to remember than individual thoracic lymph node stations/levels. For more information see http://dx.doi.org/10.1097/JTO.0b013e3181a0d82e

CTCAE version
type: Class
subclass of: Version
creator: Andre Dekker
definition: Version of the Common Terminology Criteria for Adverse Events (CTCAE) system published by the US National Cancer Institute (NCI).

CTCAE v4.0
type: Class
subclass of: CTCAE version
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Fourth version (published 2009-2010) of the Common Terminology Criteria for Adverse Events (CTCAE) system published by the US National Cancer Institute (NCI).

CTCAE v3.0
type: Class
subclass of: CTCAE version
creator: Andre Dekker
definition: Third version (published 2003-2006) of the Common Terminology Criteria for Adverse Events (CTCAE) system published by the US National Cancer Institute (NCI).

CTCAE v2.0
type: Class
subclass of: CTCAE version
creator: Andre Dekker
definition: Second version (published 1998-1999) of the Common Terminology Criteria for Adverse Events (CTCAE) system published by the US National Cancer Institute (NCI).

Supraclavicular zone
type: Class
subclass of: Lymph Node by Zone and Station
creator: Andre Dekker
definition: The supraclavicular zone consists of lymph nodes of nodal station 1.

Aortic Nodes
type: Class
subclass of: Lymph Node by Zone and Station
creator: Andre Dekker
definition: Artic nodes are lymph nodes in the subaortic or para-aortic zones (nodal stations 5-6).

AP zone
type: Class
subclass of: Aortic Nodes
creator: Andre Dekker
definition: The aortopulmonary zone consists of lymph nodes of nodal stations 5-6.

Patient GUID
type: Class
subclass of: Person Identifier
creator: Andre Dekker
alternative label: Patient UUID
definition: A globally unique identifier identifying a patient.

Superior Mediastinal Nodes
type: Class
subclass of: Lymph Node by Zone and Station
creator: Andre Dekker
definition: Supoerior mediastinal nodes are lymph nodes in the upper zone (nodal stations 2-4).

DICOM Functional Concept
type: Class
subclass of: Functional Concept
creator: Andre Dekker
definition: A concept which is of interest because it pertains to the DICOM protocol. Examples are target and other Information Object Defintion and Entities.

Upper zone
type: Class
subclass of: Superior Mediastinal Nodes
creator: Andre Dekker
definition: The upper zone consists of lymph nodes of nodal stations 2-4.

D95
type: Class
subclass of: Dose Volume Histogram - Dx
creator: Andre Dekker
definition: Minimum dose to at least 95% of the volume of a target volume or organ at risk. D95 is often reported for target volumes.

D98
type: Class
subclass of: Dose Volume Histogram - Dx
creator: Andre Dekker
alternative label: Dnear-min
definition: Minimum dose to at least 98% of the volume of a target volume or organ at risk. D98 is often called the near minimum dose.

D50
type: Class
subclass of: Dose Volume Histogram - Dx
creator: Andre Dekker
alternative label: Dmedian
alternative label: Median Radiation Dose
definition: Minimum dose to at least 50% of the volume of a target volume or organ at risk. Equivalent to the median dose.

D2
type: Class
subclass of: Dose Volume Histogram - Dx
creator: Andre Dekker
alternative label: Dnear-max
definition: Minimum dose to at least 2% of the volume of a target volume or organ at risk. D98 is often called the near maximum dose.

Local control time
type: Class
subclass of: Elapsed Time
creator: Johan van Soest
definition: Elapsed time that a person has been living with/without a related observation/procedure/event/finding of local control/recurrence.

Inferior Mediastinal Nodes
type: Class
subclass of: Lymph Node by Zone and Station
creator: Andre Dekker
definition: Inferior mediastinal nodes are lymph nodes in the subcarinal or lower zones (nodal stations 7-9).

Distant control time
type: Class
subclass of: Elapsed Time
creator: Johan van Soest
definition: Elapsed time that a person has been living with/without a related observation/procedure/event/finding of distant control/recurrence.

Subcarinal zone
type: Class
subclass of: Inferior Mediastinal Nodes
creator: Andre Dekker
definition: The subcarinal zone consists of lymph nodes of nodal station 7.

Lower zone
type: Class
subclass of: Inferior Mediastinal Nodes
creator: Andre Dekker
definition: The lower zone consists of lymph nodes of nodal stations 8-9.

N1 nodes
type: Class
subclass of: Lymph Node by Zone and Station
creator: Andre Dekker
definition: N1 nodes are lymph nodes in the hilar/interlobar or peripheral zones (nodal stations 10-14).

Hilar/interlobar zone
type: Class
subclass of: N1 nodes
creator: Andre Dekker
definition: The hilar/interlobar zone consists of lymph nodes of nodal stations 10-11.

Peripheral zone
type: Class
subclass of: N1 nodes
creator: Andre Dekker
definition: The peripheral zone consists of lymph nodes of nodal stations 12-14.

Lung_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left lung
creator: Andre Dekker
definition: A region of interest based on a delineation of the left lung as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Lung_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right lung
creator: Andre Dekker
definition: A region of interest based on a delineation of the right lung as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

GTVp (ROI)
type: Class
subclass of: GTV (ROI)
subclass of: Class
  intersection of: GTV (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Gross Tumor Volume - Primary Tumor
creator: Andre Dekker
definition: A region of interest based on a delineation of the Gross Tumor Volume of a primary tumor. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

GTVn (ROI)
type: Class
subclass of: GTV (ROI)
subclass of: Class
  intersection of: GTV (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Gross Tumor Volume - Node
creator: Andre Dekker
definition: A region of interest based on a delineation of the Gross Tumor Volume of a metastatic regional node. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Overall Treatment Time - Radiotherapy
type: Class
subclass of: Class
  intersection of: Duration
  intersection of: Restriction
    on property: has_unit
    some values from: day
  intersection of: Restriction
    on property: has_value
    some values from: integer
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: OTT
definition: Overall treatment time calculated from first until the last day of radiotherapy

Radiation Therapy Alone
type: Class
subclass of: Radiation Therapy
subclass of: Unimodality Therapy
creator: Andre Dekker
definition: A treatment where only radiation is given. This is in contract to e.g. chemoradiotherapy or a combination of surgery and radiation. Can refer to use of two or more radiotherapy modalities (e.g. a combination of brachytherapy and teletherapy).

Parallel-Opposed Fields Radiation Therapy
type: Class
subclass of: Radiation Therapy
creator: Andre Dekker
definition: Parallel opposed fields radiotherapy is a simple form of radiotherapy when using multiple fields. By aiming the two beams along the same axis, the dose fall off in one will be compensated for by the increased dose in the other.

2-Dimensional Radiation Therapy
type: Class
subclass of: Radiation Therapy
creator: Andre Dekker
definition: Two-dimensional (2-D) radiotherapy is a simple form of radiotherapy where treatment planning is based on standardized treatment techniques applied to classes of patients thought to be similar. The process makes use of an X-ray simulator and a 2-D computer treatment planning system used for calculation of dose distributions.

Radiotherapy Total Treatment Dose
type: Class
subclass of: Absorbed Radiation Dose
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: TTD
definition: The total absorbed radiation dose prescribed or delivered to a tumor in a complete radiotherapy treatment.

Radiotherapy Fraction Dose
type: Class
subclass of: Absorbed Radiation Dose
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: Radiation dose delivered per fraction

Number of Radiotherapy Fractions
type: Class
subclass of: Count
creator: Andre Dekker
definition: The count of radiotherapy fractions given in a certain time interval (e.g. per day) or in a certain coherent context (e.g. per treatment).

Number of Radiotherapy Fractions Per Day
type: Class
subclass of: Number of Radiotherapy Fractions
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: The count of radiotherapy fractions given per day.

Number of Radiotherapy Fractions Per Treatment
type: Class
subclass of: Number of Radiotherapy Fractions
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: The count of radiotherapy fractions given in a radiotherapy treatment as a whole.

Dose Volume Histogram - Dx
type: Class
subclass of: Radiation Dose From Dose Volume Histogram
creator: Andre Dekker
definition: Minimum radiation dose to at least x% of the volume.

Dose Volume Histogram - Vx
type: Class
subclass of: Percentage
creator: Andre Dekker
definition: The percentage volume receiving at least x Gy

V20 of Lung
type: Class
subclass of: Dose Volume Histogram - Vx
creator: Andre Dekker
definition: The percentage of the lung volume (with subtraction of the volume involved by lung cancer) which receives radiation doses of 20 Gy or more.

Radiation Dose From Dose Volume Histogram
type: Class
subclass of: Absorbed Radiation Dose
creator: Andre Dekker
definition: A radiation dose quantity derived from a Dose Volume Histogram.

Dmean
type: Class
subclass of: Radiation Dose From Dose Volume Histogram
creator: Andre Dekker
alternative label: Mean Radiation Dose
definition: The mean radiation dose in a given region of interest.

Mean Lung Dose
type: Class
subclass of: Dmean
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
alternative label: MLD
definition: The mean radiation dose to the lung as an organ at risk (with subtraction of the volume involved by lung cancer).

Mean Esophagus Dose
type: Class
subclass of: Dmean
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: The mean radiation dose to the esophagus as an organ at risk.

Maximum Esophagus Dose
type: Class
subclass of: D0
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: The maximum radiation dose to the esophagus as an organ at risk.

D0
type: Class
subclass of: Dose Volume Histogram - Dx
creator: Andre Dekker
alternative label: Dmax
alternative label: Maximum Radiation Dose
definition: The mininum radiation dose given to at least 0% of the volume (i.e. to a single point ) of the target volume or organ at risk. Equivalent to the maximum radiation dose.

FEV1 with Medication
type: Class
subclass of: Forced Expiratory Volume in 1 Second
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: The FEV1 measured during bronchodilation and/or steroid use.

Percent Predicted Diffusion Capacity of the Lung for Carbon Monoxide
type: Class
subclass of: Percentage
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: The degree to which inhaled carbon monoxide diffuses from the alveoli into the blood, expressed as a proportion of the predicted normal value.

Acute Radiation Therapy Adverse Event
type: Class
subclass of: Adverse Event by Time of Onset
creator: Andre Dekker
alternative label: Early Radiation Therapy Adverse Event
definition: Toxicity from radiation therapy. The critera are relevant from day 1, the commencement of therapy, through day 90. (RTOG definition)

Adverse Event by Time of Onset
type: Class
subclass of: Adverse Event
creator: Andre Dekker
definition: Adverse event categorized by the time of onset. Typically adverse events are considered either acute/early or late relative to an intervention.

Late Radiation Therapy Adverse Event
type: Class
subclass of: Adverse Event by Time of Onset
creator: Andre Dekker
definition: All effects seen after 90 days from the beginning of radiation therapy.

Definitely Related to Cancer
type: Class
subclass of: Adverse Event Attribution Category
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A characteristic used to qualify the adverse event as certainly related to cancer.

Unrelated to Cancer
type: Class
subclass of: Adverse Event Attribution Category
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A characteristic used to qualify the adverse event as clearly not related to cancer.

Unlikely Related to Cancer
type: Class
subclass of: Adverse Event Attribution Category
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A characteristic used to qualify the adverse event as unlikely related to cancer.

Possibly Related to Cancer
type: Class
subclass of: Adverse Event Attribution Category
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A characteristic indicating that an adverse event may be related to cancer.

Probably Related to Cancer
type: Class
subclass of: Adverse Event Attribution Category
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A characteristic used to qualify the adverse event as likely related to cancer.

Probably Related to Pre-existing Comorbidity
type: Class
subclass of: Adverse Event Attribution Category
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A characteristic used to qualify the adverse event as likely related to pre-existing comorbidity.

Possibly Related to Pre-existing Comorbidity
type: Class
subclass of: Adverse Event Attribution Category
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A characteristic indicating that an adverse event may be related to pre-existing comorbidity.

Definitely Related to Pre-existing Comorbidity
type: Class
subclass of: Adverse Event Attribution Category
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A characteristic used to qualify the adverse event as certainly related to pre-existing comorbidity.

Conditionally Related to Pre-existing Comorbidity
type: Class
subclass of: Adverse Event Attribution Category
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A characteristic used to qualify the adverse event as unclassified in term of its relation to pre-existing comorbidity.

Conditionally Related to Cancer
type: Class
subclass of: Adverse Event Attribution Category
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A characteristic used to qualify the adverse event as unclassified in term of its relation to cancer.

Unrelated to Pre-existing Comorbidity
type: Class
subclass of: Adverse Event Attribution Category
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A characteristic used to qualify the adverse event as clearly not related to pre-existing comorbidity.

Unlikely Related to Pre-existing Comorbidity
type: Class
subclass of: Adverse Event Attribution Category
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A characteristic used to qualify the adverse event as unlikely related to pre-existing comorbidity.

Relation to Cancer Unclassifiable
type: Class
subclass of: Adverse Event Attribution Category
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A characteristic used to qualify the adverse event as unclassifiable in term of its relation to cancer.

Relation to Pre-existing Comorbidity Unclassifiable
type: Class
subclass of: Adverse Event Attribution Category
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A characteristic used to qualify the adverse event as unclassifiable in term of its relation to pre-existing comorbidity.

ECOG Performance Status≥2
type: Class
equivalent class: Class
  union of: ECOG Performance Status 2
  union of: ECOG Performance Status 3
  union of: ECOG Performance Status 4
  union of: ECOG Performance Status 5
subclass of: ECOG Performance Status
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: A performance status which is ECOG 2 or worse.

Never or Former Smoker
type: Class
equivalent class: Class
  union of: Never Smoker
  union of: Former Smoker
subclass of: Smoking Status
creator: Andre Dekker
definition: A person who was not smoking at the time of consideration and may or may not have smoked in the past.

Both Lobes of the Left Lung
type: Class
subclass of: Multiple Lobes of the Lung
creator: Andre Dekker
definition: An area in the body consisting of both left lung lobes. E.g. a lung cancer may have grown into both lobes of the left lung.

Minimum of 5 Positive Lymph Node Stations
type: Class
equivalent class: Class
  intersection of: Positive Lymph Node Stations
  intersection of: Restriction
    on property: has_value
    min qualified cardinality: 5
    on data range: integer
subclass of: Positive Lymph Node Stations
creator: Andre Dekker
definition: A count of at least 5 positive lymph node stations assessed by FDG-PET scan.

T0 or T1 Stage Finding
type: Class
equivalent class: Class
  union of: T0 Stage Finding
  union of: T1 Stage Finding
subclass of: Generic Primary Tumor TNM Finding
creator: Andre Dekker
definition: A primary tumor TNM finding indicating that there is either no evidence of primary tumor (T0) or that the cancer is limited to the site of growth (T1).

Medical Contraindication to Concurrent Chemoradiotherapy
type: Class
subclass of: Medical Contraindication
subclass of: Class
  intersection of: Medical Contraindication
  intersection of: Restriction
    on property: prevents
    some values from: Concurrent Chemoradiotherapy
creator: Andre Dekker
definition: A symptom or medical condition that makes a concurrent chemoradiotherapy inadvisable because a person is likely to have a bad reaction.

Equivalent 2Gy Dose
type: Class
subclass of: Absorbed Radiation Dose
creator: Andre Dekker
alternative label: EQD2
definition: Equivalent 2Gy dose: EQD2 = n * d * (d + α/β) / (2 + α/β)

Minimum of 5 Positive Mediastinal Lymph Node Stations
type: Class
equivalent class: Class
  intersection of: Positive Mediastinal Lymph Node Stations
  intersection of: Restriction
    on property: has_value
    min qualified cardinality: 5
    on data range: integer
subclass of: Positive Mediastinal Lymph Node Stations
creator: Andre Dekker
definition: A count of at least 5 positive lymph node stations assessed by FDG-PET scan using only mediastinal stations (excluding stations 10-14).

MainBronchus_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right main bronchus
creator: Andre Dekker
definition: A region of interest based on a delineation of the right main bronchus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

A_Pulmonary_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left pulmonary artery
creator: Andre Dekker
definition: A region of interest based on a delineation of the left pulmonary artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

A_Pulmonary_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right pulmonary artery
creator: Andre Dekker
definition: A region of interest based on a delineation of the right pulmonary artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

A_Carotid_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right common carotid artery
creator: Andre Dekker
definition: A region of interest based on a delineation of the right common carotid artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

A_Carotid_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left common carotid artery
creator: Andre Dekker
definition: A region of interest based on a delineation of the left common carotid artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

A_Coronary_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left coronary artery
creator: Andre Dekker
definition: A region of interest based on a delineation of the left coronary artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

A_Coronary_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right coronary artery
creator: Andre Dekker
definition: A region of interest based on a delineation of the right coronary artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

A_HypophysealInferior (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Inferior hypophysial artery
creator: Andre Dekker
definition: A region of interest based on a delineation of the inferior hypophysial artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

A_Subclavicular_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left subclavian artery
creator: Andre Dekker
definition: A region of interest based on a delineation of the left subclavian artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

A_Subclavicular_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right subclavian artery
creator: Andre Dekker
definition: A region of interest based on a delineation of the right subclavian artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

A_HypophysealInferior_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left inferior hypophyseal artery
creator: Andre Dekker
definition: A region of interest based on a delineation of the left inferior hypophyseal artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

A_HypophysealInferior_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right inferior hypophyseal artery
creator: Andre Dekker
definition: A region of interest based on a delineation of the right inferior hypophyseal artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

A_HypophysealSuperior_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left superior hypophyseal artery
creator: Andre Dekker
definition: A region of interest based on a delineation of the left superior hypophyseal artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

A_HypophysealSuperior_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right superior hypophyseal artery
creator: Andre Dekker
definition: A region of interest based on a delineation of the right superior hypophyseal artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Atrium_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left atrium
creator: Andre Dekker
definition: A region of interest based on a delineation of the left atrium as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Atrium_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right atrium
creator: Andre Dekker
definition: A region of interest based on a delineation of the right atrium as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

BrachialPlexus_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left brachial nerve plexus
creator: Andre Dekker
definition: A region of interest based on a delineation of the left brachial nerve plexus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

BrachialPlexus_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right brachial nerve plexus
creator: Andre Dekker
definition: A region of interest based on a delineation of the right brachial nerve plexus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Breast_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left breast
creator: Andre Dekker
definition: A region of interest based on a delineation of the left breast as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Breast_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right breast
creator: Andre Dekker
definition: A region of interest based on a delineation of the right breast as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

BronchialTree_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left bronchial tree
creator: Andre Dekker
definition: A region of interest based on a delineation of the left bronchial tree as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

BronchialTree_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right bronchial tree
creator: Andre Dekker
definition: A region of interest based on a delineation of the right bronchial tree as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Cerebrum_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left cerebral hemisphere
creator: Andre Dekker
definition: A region of interest based on a delineation of the left cerebral hemisphere as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Cerebrum_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right cerebral hemisphere
creator: Andre Dekker
definition: A region of interest based on a delineation of the right cerebral hemisphere as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

CN_VII_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left facial nerve
creator: Andre Dekker
definition: A region of interest based on a delineation of the left facial nerve as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

CN_VII_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right facial nerve
creator: Andre Dekker
definition: A region of interest based on a delineation of the right facial nerve as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

CN_VIII_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left vestibulocochlear nerve
creator: Andre Dekker
definition: A region of interest based on a delineation of the left vestibulocochlear nerve as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

CN_VIII_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right vestibulocochlear nerve
creator: Andre Dekker
definition: A region of interest based on a delineation of the right vestibulocochlear nerve as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Cochlea_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left cochlea
creator: Andre Dekker
definition: A region of interest based on a delineation of the left cochlea as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Cochlea_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right cochlea
creator: Andre Dekker
definition: A region of interest based on a delineation of the right cochlea as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Cornea_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left cornea
creator: Andre Dekker
definition: A region of interest based on a delineation of the left cornea as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Cornea_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right cornea
creator: Andre Dekker
definition: A region of interest based on a delineation of the right cornea as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Ear_External_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left external ear
creator: Andre Dekker
definition: A region of interest based on a delineation of the left external ear as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Ear_External_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right external ear
creator: Andre Dekker
definition: A region of interest based on a delineation of the right external ear as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Ear_Middle_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left middle ear
creator: Andre Dekker
definition: A region of interest based on a delineation of the left middle ear as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Ear_Middle_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right middle ear
creator: Andre Dekker
definition: A region of interest based on a delineation of the right middle ear as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Eye_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left eye
creator: Andre Dekker
definition: A region of interest based on a delineation of the left eye as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Eye_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right eye
creator: Andre Dekker
definition: A region of interest based on a delineation of the right eye as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

FemoralJoint_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left hip joint
creator: Andre Dekker
definition: A region of interest based on a delineation of the left hip joint as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

FemoralJoint_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right hip joint
creator: Andre Dekker
definition: A region of interest based on a delineation of the right hip joint as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Femur_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left femur
creator: Andre Dekker
definition: A region of interest based on a delineation of the left femur as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Femur_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right femur
creator: Andre Dekker
definition: A region of interest based on a delineation of the right femur as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

FrontalLobe_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left frontal lobe
creator: Andre Dekker
definition: A region of interest based on a delineation of the left frontal lobe as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

FrontalLobe_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right frontal lobe
creator: Andre Dekker
definition: A region of interest based on a delineation of the right frontal lobe as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

GHJoint_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left glenohumeral joint
creator: Andre Dekker
definition: A region of interest based on a delineation of the left glenohumeral joint as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

GHJoint_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right glenohumeral joint
creator: Andre Dekker
definition: A region of interest based on a delineation of the right glenohumeral joint as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Globe_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left eyeball
creator: Andre Dekker
definition: A region of interest based on a delineation of the left eyeball as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Globe_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right eyeball
creator: Andre Dekker
definition: A region of interest based on a delineation of the right eyeball as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Hippocampus_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left hippocampus
creator: Andre Dekker
definition: A region of interest based on a delineation of the left hippocampus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Hippocampus_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right hippocampus
creator: Andre Dekker
definition: A region of interest based on a delineation of the right hippocampus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

MassMuscle_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left masseter
creator: Andre Dekker
definition: A region of interest based on a delineation of the left masseter as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

MassMuscle_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right masseter
creator: Andre Dekker
definition: A region of interest based on a delineation of the right masseter as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

OccipitalLobe_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left occipital lobe
creator: Andre Dekker
definition: A region of interest based on a delineation of the left occipital lobe as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

OccipitalLobe_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right occipital lobe
creator: Andre Dekker
definition: A region of interest based on a delineation of the right occipital lobe as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

OpticNerve_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left optic nerve
creator: Andre Dekker
definition: A region of interest based on a delineation of the left optic nerve as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

OpticNerve_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right optic nerve
creator: Andre Dekker
definition: A region of interest based on a delineation of the right optic nerve as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Ovary_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left ovary
creator: Andre Dekker
definition: A region of interest based on a delineation of the left ovary as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Ovary_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right ovary
creator: Andre Dekker
definition: A region of interest based on a delineation of the right ovary as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

ParietalLobe_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left parietal lobe
creator: Andre Dekker
definition: A region of interest based on a delineation of the left parietal lobe as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

ParietalLobe_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right parietal lobe
creator: Andre Dekker
definition: A region of interest based on a delineation of the right parietal lobe as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Parotid_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left parotid gland
creator: Andre Dekker
definition: A region of interest based on a delineation of the left parotid gland as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Parotid_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right parotid gland
creator: Andre Dekker
definition: A region of interest based on a delineation of the right parotid gland as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Retina_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left retina
creator: Andre Dekker
definition: A region of interest based on a delineation of the left retina as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Retina_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left retina
creator: Andre Dekker
definition: A region of interest based on a delineation of the left retina as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Rib1_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left first rib
creator: Andre Dekker
definition: A region of interest based on a delineation of the left first rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Rib2_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left second rib
creator: Andre Dekker
definition: A region of interest based on a delineation of the left second rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Rib3_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left third rib
creator: Andre Dekker
definition: A region of interest based on a delineation of the left third rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Rib4_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left fourth rib
creator: Andre Dekker
definition: A region of interest based on a delineation of the left fourth rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Rib5_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left fifth rib
creator: Andre Dekker
definition: A region of interest based on a delineation of the left fifth rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Rib6_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left sixth rib
creator: Andre Dekker
definition: A region of interest based on a delineation of the left sixth rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Rib7_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left seventh rib
creator: Andre Dekker
definition: A region of interest based on a delineation of the left seventh rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Rib8_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left eighth rib
creator: Andre Dekker
definition: A region of interest based on a delineation of the left eighth rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Rib9_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left ninth rib
creator: Andre Dekker
definition: A region of interest based on a delineation of the left ninth rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Rib10_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left tenth rib
creator: Andre Dekker
definition: A region of interest based on a delineation of the left tenth rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Rib11_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left eleventh rib
creator: Andre Dekker
definition: A region of interest based on a delineation of the left eleventh rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Rib12_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left twelfth rib
creator: Andre Dekker
definition: A region of interest based on a delineation of the left twelfth rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Rib12_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right twelfth rib
creator: Andre Dekker
definition: A region of interest based on a delineation of the right twelfth rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Rib11_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right eleventh rib
creator: Andre Dekker
definition: A region of interest based on a delineation of the right eleventh rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Rib10_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right tenth rib
creator: Andre Dekker
definition: A region of interest based on a delineation of the right tenth rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Rib9_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right ninth rib
creator: Andre Dekker
definition: A region of interest based on a delineation of the right ninth rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Rib8_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right eighth rib
creator: Andre Dekker
definition: A region of interest based on a delineation of the right eighth rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Rib7_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right seventh rib
creator: Andre Dekker
definition: A region of interest based on a delineation of the right seventh rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Rib6_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right sixth rib
creator: Andre Dekker
definition: A region of interest based on a delineation of the right sixth rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Rib5_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right fifth rib
creator: Andre Dekker
definition: A region of interest based on a delineation of the right fifth rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Rib4_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right fourth rib
creator: Andre Dekker
definition: A region of interest based on a delineation of the right fourth rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Rib3_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right third rib
creator: Andre Dekker
definition: A region of interest based on a delineation of the right third rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Rib2_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right second rib
creator: Andre Dekker
definition: A region of interest based on a delineation of the right second rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Rib1_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right first rib
creator: Andre Dekker
definition: A region of interest based on a delineation of the right first rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

SeminalVesicle_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left seminal vesicle
creator: Andre Dekker
definition: A region of interest based on a delineation of the left seminal vesicle as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

SeminalVesicle_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right seminal vesicle
creator: Andre Dekker
definition: A region of interest based on a delineation of the right seminal vesicle as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Submandibular_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left submandibular gland
creator: Andre Dekker
definition: A region of interest based on a delineation of the left submandibular gland as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Submandibular_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right submandibular gland
creator: Andre Dekker
definition: A region of interest based on a delineation of the right submandibular gland as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

TemporalLobe_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left temporal lobe
creator: Andre Dekker
definition: A region of interest based on a delineation of the left temporal lobe as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

TemporalLobe_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right temporal lobe
creator: Andre Dekker
definition: A region of interest based on a delineation of the right temporal lobe as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Testis_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left testis
creator: Andre Dekker
definition: A region of interest based on a delineation of the left testis as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Testis_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right testis
creator: Andre Dekker
definition: A region of interest based on a delineation of the right testis as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

TMjoint_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left temporomandibular joint
creator: Andre Dekker
definition: A region of interest based on a delineation of the left temporomandibular joint as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

TMjoint_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right temporomandibular joint
creator: Andre Dekker
definition: A region of interest based on a delineation of the right temporomandibular joint as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

V_SubClav_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left subclavian vein
creator: Andre Dekker
definition: A region of interest based on a delineation of the left subclavian vein as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

V_SubClav_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right subclavian vein
creator: Andre Dekker
definition: A region of interest based on a delineation of the right subclavian vein as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_C1 (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Atlas
creator: Andre Dekker
definition: A region of interest based on a delineation of the atlas as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_C2 (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Axis
creator: Andre Dekker
definition: A region of interest based on a delineation of the axis as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_C3 (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Third cervical vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the third cervical vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_C4 (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Fourth cervical vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the fourth cervical vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_C5 (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Fifth cervical vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the fifth cervical vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_C6 (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Sixth cervical vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the sixth cervical vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_C7 (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Seventh cervical vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the seventh cervical vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_L1 (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: First lumbar vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the first lumbar vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_L2 (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Second lumbar vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the second lumbar vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_L3 (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Third lumbar vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the third lumbar vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_L4 (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Fourth lumbar vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the fourth lumbar vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_L5 (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Fifth lumbar vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the fifth lumbar vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_S1 (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: First sacral vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the first sacral vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_S2 (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Second sacral vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the second sacral vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_S3 (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Third sacral vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the third sacral vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_S4 (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Fourth sacral vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the fourth sacral vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_S5 (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Fifth sacral vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the fifth sacral vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_T1 (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: First thoracic vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the first thoracic vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_T2 (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Second thoracic vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the second thoracic vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_T3 (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Third thoracic vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the third thoracic vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_T4 (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Fourth thoracic vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the fourth thoracic vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_T5 (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Fifth thoracic vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the fifth thoracic vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_T6 (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Sixth thoracic vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the sixth thoracic vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_T7 (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Seventh thoracic vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the seventh thoracic vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_T8 (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Eighth thoracic vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the eighth thoracic vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_T9 (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Ninth thoracic vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the ninth thoracic vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_T10 (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Tenth thoracic vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the tenth thoracic vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_T11 (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Eleventh thoracic vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the eleventh thoracic vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

VB_T12 (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Twelfth thoracic vertebra
creator: Andre Dekker
definition: A region of interest based on a delineation of the twelfth thoracic vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Ventricle_L (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Left ventricle
creator: Andre Dekker
definition: A region of interest based on a delineation of the left ventricle as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Ventricle_R (ROI)
type: Class
subclass of: Class
  intersection of: Organ at Risk (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Right ventricle
creator: Andre Dekker
definition: A region of interest based on a delineation of the right ventricle as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Gross Tumor Volume - Metastasis
type: Class
subclass of: Gross Tumor Volume
creator: Andre Dekker
definition: The gross tumor volume of a distant metastasis of a tumor.

CTV (ROI)
type: Class
subclass of: Target Volume (ROI)
subclass of: Class
  intersection of: Target Volume (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Clinical Target Volume
creator: Andre Dekker
definition: A region of interest based on a delineation of the Clinical Target Volume. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Clinical Target Volume - Node
type: Class
subclass of: Clinical Target Volume
creator: Andre Dekker
alternative label: CTVn
definition: The clinical target volume of a metastatic regional node of a tumor.

Clinical Target Volume - Primary Tumor
type: Class
subclass of: Clinical Target Volume
creator: Andre Dekker
definition: The clinical target volume of a primary tumor.

ITV (ROI)
type: Class
subclass of: Target Volume (ROI)
subclass of: Class
  intersection of: Target Volume (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Internal Target Volume
creator: Andre Dekker
definition: A region of interest based on a delineation of the Internal Target Volume.

PRV (ROI)
type: Class
subclass of: Radiation Oncology Region of Interest
creator: Andre Dekker
definition: A region of interest based on a delineation of a Planning Organ at Risk Volume (PRV). The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Radiation Oncology Functional Concept
type: Class
subclass of: Functional Concept
creator: Andre Dekker
definition: A concept which is of interest because it pertains to the carrying out of radiation oncology. Examples are target and other irradiated volumes, margins etc.

Gross Tumor Volume
type: Class
subclass of: Target Volume
creator: Andre Dekker
alternative label: GTV
definition: The Gross Tumor Volume (GTV) is the gross demonstrable extent and location of the tumor. The GTV may consist of a primary tumor (primary tumor GTV or GTV-T), metastatic regional node(s) (nodal GTV or GTV-N), or distant metastasis (metastatic GTV, or GTV-M). Typically, different GTVs are defined for the primary tumor and the regional node(s). But in some particular clinical situations, it might well be that the metastatic node cannot be distinguished from the primary tumor, e.g., a nasopharyngeal undifferentiated carcinoma infiltrating posterolaterally into the retropharyngeal space, including possible infiltrated nodes. In such situations, a single GTV encompassing both the primary tumor and the node(s) may be delineated. (ICRU 83) For more information: http://dx.doi.org/10.1093/jicru/ndq001

Internal Target Volume
type: Class
subclass of: Target Volume
creator: Andre Dekker
alternative label: ITV
definition: In ICRU Report 62 (ICRU, 1999), the Internal Target Volume (ITV) was defined as the CTV plus a margin taking into account uncertainties in size, shape, and position of the CTV within the patient. Such a margin was called the internal margin as opposed to the set-up margin. In ICRU Report 62, it was recommended that internal and external margins be added quadratically, but often in practice they are instead added linearly, which can lead to an unacceptably large margin. The ITV might be useful only in clinical situations in which uncertainty concerning the CTV location dominates setup uncertainties and/or when they are independent. The ITV is considered an optional tool in helping to delineate the PTV. (ICRU 83) For more information: http://dx.doi.org/10.1093/jicru/ndq001

Planning Target Volume
type: Class
subclass of: Target Volume
creator: Andre Dekker
alternative label: PTV
definition: The Planning Target Volume (PTV) is a geometrical concept introduced for treatment planning and evaluation. It is the recommended tool to shape absorbed-dose distributions to ensure that the prescribed absorbed dose will actually be delivered to all parts of the CTV with a clinically acceptable probability, despite geometrical uncertainties such as organ motion and setup variations. It is also used for absorbed-dose prescription and reporting. It surrounds the representation of the CTV with a margin such that the planned absorbed dose is delivered to the CTV. This margin takes into account both the internal and the setup uncertainties. The setup margin accounts specifically for uncertainties in patient positioning and alignment of the therapeutic beams during the treatment planning, and through all treatment sessions. (ICRU 83) For more information: http://dx.doi.org/10.1093/jicru/ndq001

Clinical Target Volume
type: Class
subclass of: Target Volume
creator: Andre Dekker
alternative label: CTV
definition: The Clinical Target Volume (CTV) is a volume of tissue that contains a demonstrable GTV and/or subclinical malignant disease with a certain probability of occurrence considered relevant for therapy. There is no general consensus on what probability is considered relevant for therapy, but typically a probability of occult disease higher than from 5 % to 10 % is assumed to require treatment. This remains a clinical judgment in which the type of malignancy, the consequence of failure, and the expected feasibility of salvage treatment need to be considered. (ICRU 83) For more information: http://dx.doi.org/10.1093/jicru/ndq001

CTVn (ROI)
type: Class
subclass of: CTV (ROI)
subclass of: Class
  intersection of: CTV (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Clinical Target Volume - Node
creator: Andre Dekker
definition: A region of interest based on a delineation of the Clinical Target Volume of a metastatic regional node. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Clinical Target Volume - Metastasis
type: Class
subclass of: Clinical Target Volume
creator: Andre Dekker
definition: The clinical target volume of a distant metasasis of a tumor.

CTVp (ROI)
type: Class
subclass of: CTV (ROI)
subclass of: Class
  intersection of: CTV (ROI)
  intersection of: Restriction
    on property: delineation_of
    some values from: Clinical Target Volume - Primary Tumor
creator: Andre Dekker
definition: A region of interest based on a delineation of the Clinical Target Volume of a primary tumor. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Gross Tumor Volume - Node
type: Class
subclass of: Gross Tumor Volume
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: The gross tumor volume of a metastatic regional node of a tumor.

Gross Tumor Volume - Primary Tumor
type: Class
subclass of: Gross Tumor Volume
creator: Andre Dekker
see also: EuroCAT Umbrella Protocol for NSCLC
definition: The gross tumor volume of a primary tumor.

Target Volume
type: Class
subclass of: Radiation Oncology Functional Concept
creator: Andre Dekker
definition: A Target Volume is a volume of tissue or of a geometrical concept forming the target for irradiation during radiation oncology.

Planning Organ at Risk Volume
type: Class
subclass of: Radiation Oncology Functional Concept
creator: Andre Dekker
definition: The Planning Organ at Risk Volume (PRV) is a geometrical concept introduced for treatment planning and evaluation. It surrounds the representation of the Organ at Risk (OAR) with a margin. This margin takes into account both the internal and the setup uncertainties. The setup margin accounts specifically for uncertainties in patient positioning and alignment of the therapeutic beams during the treatment planning, and through all treatment sessions. (ICRU 83) For more information: http://dx.doi.org/10.1093/jicru/ndq001

Organ at Risk
type: Class
subclass of: Radiation Oncology Functional Concept
creator: Andre Dekker
definition: The Organ-At-Risk (OAR) or critical normal structures are tissues that if irradiated could suffer significant morbidity and thus might influence the treatment planning and/or the absorbed-dose prescription. (ICRU 83) For more information: http://dx.doi.org/10.1093/jicru/ndq001

PTVn (ROI)
type: Class
subclass of: PTV (ROI)
creator: Andre Dekker
definition: A region of interest based on a delineation of the Planning Target Volume of a metastatic regional node. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

PTVp (ROI)
type: Class
subclass of: PTV (ROI)
creator: Andre Dekker
definition: A region of interest based on a delineation of the Planning Target Volume of a primary tumor. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054).

Planning Target Volume - Metastasis
type: Class
subclass of: Planning Target Volume
creator: Andre Dekker
definition: The Planning Target Volume of a distant metasasis of a tumor.

Planning Target Volume - Node
type: Class
subclass of: Planning Target Volume
creator: Andre Dekker
definition: The Planning Target Volume of a metastatic regional node of a tumor.

Planning Target Volume - Primary Tumor
type: Class
subclass of: Planning Target Volume
creator: Andre Dekker
definition: The Planning Target Volume of a primary tumor.

Treated Volume
type: Class
subclass of: Radiation Oncology Functional Concept
creator: Andre Dekker
definition: The TV is the volume of tissue enclosed within a specific isodose envelope, with the absorbed dose specified by the radiation oncology team as appropriate to achieve tumor eradication or palliation, within the bounds of acceptable complications. As proposed in proton therapy (ICRU, 2007), D98% could be selected to determine the TV in photon therapy. When reported, the value of the isodose selected to define the TV should be quoted either relative to the prescribed absorbed dose or in absolute terms. It is important to identify the shape, size, and position of the TV in relation to the PTV for several reasons. One reason is to provide information to evaluate causes for local recurrences (inside or outside the TV).(ICRU 83) For more information: http://dx.doi.org/10.1093/jicru/ndq001

Metabolic Tumor Volume
type: Class
subclass of: Image Feature
creator: Andre Dekker
definition: Metabolic tumor volume (MTV) is the volume of tumor tissues with increased FDG uptake measured by an 18F-FDG PET scan.

FUMIR Regimen
type: Class
subclass of: Chemotherapy Regimen Used to Treat Colorectal Carcinoma
subclass of: Restriction
  on property: uses
  some values from: Mitomycin
subclass of: Restriction
  on property: uses
  some values from: Fluorouracil
creator: Andre Dekker
definition: Regimen combining Mitomycin and Fluorouracil (with concurrent radiation)

Tumor Regression Grade - Dworak
type: Class
subclass of: Tumor Regression Grade
creator: Andre Dekker
definition: Tumor regression grade according to the Dworak system.

Tumor Regression Grade - Mandard
type: Class
subclass of: Tumor Regression Grade
creator: Andre Dekker
definition: Tumor regression grade according to the Mandard system.

TRG1 - Mandard
type: Class
subclass of: Tumor Regression Grade - Mandard
subclass of: Complete Regression
creator: Andre Dekker

Complete Regression
type: Class
subclass of: Tumor Regression Grade
creator: Andre Dekker

Near Complete Regression
type: Class
subclass of: Tumor Regression Grade
creator: Andre Dekker

Moderate Regression
type: Class
subclass of: Tumor Regression Grade
creator: Andre Dekker

Minimal Regression
type: Class
subclass of: Tumor Regression Grade
creator: Andre Dekker

No Regression
type: Class
subclass of: Tumor Regression Grade
creator: Andre Dekker

TRG2 - Mandard
type: Class
subclass of: Tumor Regression Grade - Mandard
subclass of: Near Complete Regression
creator: Andre Dekker

TRG3 - Mandard
type: Class
subclass of: Tumor Regression Grade - Mandard
subclass of: Moderate Regression
creator: Andre Dekker

TRG4 - Mandard
type: Class
subclass of: Tumor Regression Grade - Mandard
subclass of: Minimal Regression
creator: Andre Dekker

TRG5 - Mandard
type: Class
subclass of: Tumor Regression Grade - Mandard
subclass of: No Regression
creator: Andre Dekker

TRG0 - Dworak
type: Class
subclass of: Tumor Regression Grade - Dworak
subclass of: No Regression
creator: Andre Dekker

TRG1 - Dworak
type: Class
subclass of: Tumor Regression Grade - Dworak
subclass of: Minimal Regression
creator: Andre Dekker

TRG2 - Dworak
type: Class
subclass of: Tumor Regression Grade - Dworak
subclass of: Moderate Regression
creator: Andre Dekker

TRG3 - Dworak
type: Class
subclass of: Tumor Regression Grade - Dworak
subclass of: Near Complete Regression
creator: Andre Dekker

TRG4 - Dworak
type: Class
subclass of: Tumor Regression Grade - Dworak
subclass of: Complete Regression
creator: Andre Dekker

Motion Management Procedure
type: Class
subclass of: Intervention or Procedure
creator: Andre Dekker
definition: A procedure in which internal motion is managed of organs and/or regions of interest (e.g. tumors) during radiotherapy or imaging or another therapeutic or imaging procedure. This management can be implicit in the procedure (e.g. 4D-CT) are added to any procedure (e.g. breath hold). The motion can be due to respiration, circulation, peristalsis, swallowing, etc. Both procedures to prevent motion (e.g. breath hold) and/or deal with motion (e.g. gating) are part of this class of concepts. Not meant here are procedures meant to deal with the overal motion of the patient (e.g immobilisation).

Deep Inspiration Breath-Hold
type: Class
subclass of: Breathing Modification Procedure
creator: Andre Dekker
alternative label: DIBH
definition: Deep Inspiration Breath-Hold is mostly used in radiotherapy and involves the patient inspiring to a specified threshold and then holding that level of inspiration during the delivery of radiation.

Breathing Modification Procedure
type: Class
subclass of: Motion Management Procedure
creator: Andre Dekker
definition: A class of procedures where respiratory motion is managed by patients temporarily changing the way they breath, either forced or voluntary and for either therapeutic or diagnostic procedures.

Abdominal Compression
type: Class
subclass of: Breathing Modification Procedure
creator: Andre Dekker
definition: A procedure which compresses the abdomen and thereby forcing the patient to use shallow breathing. This in turn reduces the motion associated with respiration.

Respiratory Gated Radiation Therapy
type: Class
subclass of: Radiation Therapy
subclass of: Motion Management Procedure
creator: Andre Dekker
definition: In respiratory gated radiation therapy the beam is switched on when the tumor is in the right phase of the respiration.

Tumor Tracking Radiation Therapy
type: Class
subclass of: Radiation Therapy
subclass of: Motion Management Procedure
creator: Andre Dekker
definition: In tumor tracking radiation therapy the beam is always on and follows the tumor during respiration. It often involves implanting fiducial markers into the tumor.

Partial Mesorectal Excision
type: Class
subclass of: Abdominal Surgical Procedure
subclass of: Therapeutic Surgical Procedure
creator: Andre Dekker
alternative label: PME
definition: Surgical procedure for rectosigmoid and upper rectal cancers where the rectum is transected 5 cm below the tumor.

Unilateral Lymph Node Dissection
type: Class
subclass of: Regional Lymph Node Dissection
creator: Andre Dekker
definition: Lymph node dissection on only one side of regional lymph nodes. This is usually done when the tumor is located on that side of the body.

Bilateral Lymph Node Dissection
type: Class
subclass of: Regional Lymph Node Dissection
creator: Andre Dekker
definition: Lymph node dissection on both sides of regional lymph nodes. This is usually done when the tumor is centrally located .

Extra mesorectal lymph node group
type: Class
equivalent class: Class
  complement of: Mesorectal lymph node group
subclass of: Lymph node group
creator: Andre Dekker
definition: Lymph nodes outside the mesorectum.

Anal sphincter
type: Class
subclass of: Body Part, Organ, or Organ Component
definition: Either of two sphincters controlling the closing of the anus: a : an outer sphincter of striated muscle extending from the coccyx to the central tendinous part of the perineum and surrounding the anus immediately beneath the skin—called also external anal sphincter, sphincter ani externus b : an inner sphincter formed by thickening of the circular smooth muscle of the rectum—called also internal anal sphincter, sphincter ani internus pecify internal or external.