mitochondrion inheritance
type: Class
subclass of: GO_0048308
subclass of: GO_0048311
IAO_0000115: The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton.
has exact synonym: mitochondrial inheritance

mitochondrial genome maintenance
type: Class
subclass of: GO_0007005
IAO_0000115: The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.

reproduction
type: Class
subclass of: GO_0008150
IAO_0000115: The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms.
has exact synonym: reproductive physiological process
replaces: GO_0019952
replaces: GO_0050876

obsolete ribosomal chaperone activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Assists in the correct assembly of ribosomes or ribosomal subunits in vivo, but is not a component of the assembled ribosome when performing its normal biological function.

high-affinity zinc transmembrane transporter activity
type: Class
subclass of: GO_0005385
IAO_0000115: Enables the transfer of zinc ions (Zn2+) from one side of a membrane to the other, probably powered by proton motive force. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
has exact synonym: high affinity zinc uptake transmembrane transporter activity
has related synonym: high-affinity zinc uptake transmembrane transporter activity

low-affinity zinc ion transmembrane transporter activity
type: Class
subclass of: GO_0005385
IAO_0000115: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.

obsolete thioredoxin
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase. Interacts with a broad range of proteins by a redox mechanism, based on the reversible oxidation of 2 cysteine thiol groups to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. The net result is the covalent interconversion of a disulfide and a dithiol.
replaces: GO_0000013

alpha-1,6-mannosyltransferase activity
type: Class
subclass of: mannosyltransferase activity
IAO_0000115: Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->6) linkage.
has exact synonym: 1,6-alpha-mannosyltransferase activity

trans-hexaprenyltranstransferase activity
type: Class
subclass of: prenyltransferase activity
IAO_0000115: Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate.
has related synonym: all-trans-heptaprenyl-diphosphate synthase activity
has related synonym: HepPP synthase activity
has related synonym: heptaprenyl diphosphate synthase activity
has related synonym: heptaprenyl pyrophosphate synthase activity
has related synonym: heptaprenyl pyrophosphate synthetase activity
replaces: GO_0036422

vacuole inheritance
type: Class
subclass of: GO_0007033
subclass of: GO_0048308
IAO_0000115: The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton.

single strand break repair
type: Class
subclass of: GO_0006281
IAO_0000115: The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair.

single-stranded DNA endodeoxyribonuclease activity
type: Class
subclass of: endodeoxyribonuclease activity
IAO_0000115: Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks.
has related synonym: single-stranded DNA specific endodeoxyribonuclease activity
has related synonym: ssDNA-specific endodeoxyribonuclease activity

phosphopyruvate hydratase complex
type: Class
subclass of: GO_1902494
subclass of: part-of-parent-5829
IAO_0000115: A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water.
has exact synonym: enolase complex

lactase activity
type: Class
subclass of: hydrolase activity, hydrolyzing O-glycosyl compounds
IAO_0000115: Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose.
has exact synonym: lactose galactohydrolase activity

alpha-glucoside transport
type: Class
subclass of: GO_0042946
IAO_0000115: The directed movement of alpha-glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration.

regulation of DNA recombination
type: Class
subclass of: GO_0051052
IAO_0000115: Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents.

regulation of mitotic recombination
type: Class
subclass of: regulation of DNA recombination
IAO_0000115: Any process that modulates the frequency, rate or extent of DNA recombination during mitosis.
has related synonym: regulation of recombination within rDNA repeats

obsolete negative regulation of recombination within rDNA repeats
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA.

mitotic spindle elongation
type: Class
subclass of: GO_0051231
subclass of: GO_1903047
subclass of: part-of-parent-70
subclass of: part-of-parent-278
subclass of: part-of-parent-7052
IAO_0000115: The cell cycle process in which the distance is lengthened between poles of the mitotic spindle. Mitotic spindle elongation begins during mitotic prophase and ends during mitotic anaphase B.
has related synonym: microtubule sliding involved in mitotic spindle elongation
has exact synonym: spindle elongation during mitosis
replaces: GO_1905121

maltose metabolic process
type: Class
subclass of: GO_0005984
IAO_0000115: The chemical reactions and pathways involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose), an intermediate in the catabolism of glycogen and starch.
has exact synonym: maltose metabolism
has exact synonym: malt sugar metabolic process
has exact synonym: malt sugar metabolism

maltose biosynthetic process
type: Class
subclass of: maltose metabolic process
subclass of: GO_0046351
IAO_0000115: The chemical reactions and pathways resulting in the formation of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose).
has exact synonym: maltose anabolism
has exact synonym: maltose biosynthesis
has exact synonym: maltose formation
has exact synonym: maltose synthesis
has exact synonym: malt sugar biosynthesis
has exact synonym: malt sugar biosynthetic process

maltose catabolic process
type: Class
subclass of: maltose metabolic process
subclass of: GO_0046352
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose).
has exact synonym: maltose breakdown
has exact synonym: maltose degradation
has related synonym: maltose hydrolysis
has exact synonym: malt sugar catabolic process
has exact synonym: malt sugar catabolism

alpha-1,2-mannosyltransferase activity
type: Class
subclass of: mannosyltransferase activity
IAO_0000115: Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->2) linkage.

ribosomal large subunit assembly
type: Class
subclass of: GO_0022618
subclass of: part-of-parent-42255
subclass of: part-of-parent-42273
IAO_0000115: The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit.
has related synonym: 50S ribosomal subunit assembly
has related synonym: 60S ribosomal subunit assembly

ribosomal small subunit assembly
type: Class
subclass of: GO_0022618
subclass of: part-of-parent-42255
subclass of: part-of-parent-42274
IAO_0000115: The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit.
has related synonym: 30S ribosomal subunit assembly
has related synonym: 40S ribosomal subunit assembly

mannosyltransferase activity
type: Class
subclass of: GO_0016758
subclass of: part-of-parent-97502
IAO_0000115: Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid.

mannosylphosphate transferase activity
type: Class
subclass of: GO_0016758
IAO_0000115: Catalysis of the transfer of a mannosylphosphate group from one compound to another.

cell wall mannoprotein biosynthetic process
type: Class
subclass of: GO_0006057
subclass of: GO_0031506
IAO_0000115: The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues.
has exact synonym: cell wall mannoprotein anabolism
has exact synonym: cell wall mannoprotein biosynthesis
has exact synonym: cell wall mannoprotein formation
has exact synonym: cell wall mannoprotein synthesis

alpha-1,3-mannosyltransferase activity
type: Class
subclass of: mannosyltransferase activity
IAO_0000115: Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage.

adenine deaminase activity
type: Class
subclass of: GO_0016814
subclass of: GO_0019239
IAO_0000115: Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3.
has related synonym: ADase activity
has related synonym: adenase activity
has related synonym: adenine aminase activity
has related synonym: adenine aminohydrolase activity

acyl binding
type: Class
subclass of: GO_0005488
IAO_0000115: Binding to an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid.
has related synonym: acyl-CoA or acyl binding

acyl carrier activity
type: Class
subclass of: GO_0044620
subclass of: GO_0140414
subclass of: part-of-parent-6633
IAO_0000115: Binding an acyl group and presenting it for processing or offloading to a cognate enzyme. Covalently binds the acyl group via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The acyl carrier protein (ACP) presents substrates to enzymes involved in fatty acid biosynthesis or in polyketide secondary metabolite biosynthesis.
has exact synonym: ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process

very long-chain fatty acid metabolic process
type: Class
subclass of: GO_0006631
IAO_0000115: The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22.
has exact synonym: very long chain fatty acid metabolic process
has exact synonym: very-long-chain fatty acid metabolic process
has exact synonym: very-long-chain fatty acid metabolism

obsolete plasma membrane long-chain fatty acid transporter
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

transition metal ion transport
type: Class
subclass of: GO_0030001
IAO_0000115: The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.
has exact synonym: transition metal transport

obsolete ascorbate stabilization
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The reduction of the ascorbate free radical to a stable form.

autophagosome assembly
type: Class
subclass of: GO_0070925
subclass of: GO_1905037
IAO_0000115: The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.
has exact synonym: autophagic vacuole assembly
has related synonym: autophagic vacuole formation
has exact synonym: autophagosome biosynthesis
has exact synonym: autophagosome formation
has related synonym: PAS formation

obsolete Rieske iron-sulfur protein
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

peptidyltransferase activity
type: Class
subclass of: GO_0016755
IAO_0000115: Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2).
has related synonym: peptidyl-tRNA:aminoacyl-tRNA N-peptidyltransferase activity

tRNA binding
type: Class
subclass of: RNA binding
IAO_0000115: Binding to a transfer RNA.
has related synonym: base pairing with tRNA
replaces: GO_0000946

urea cycle
type: Class
subclass of: GO_0019627
subclass of: GO_0043604
subclass of: GO_1901566
IAO_0000115: The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate.
has exact synonym: ornithine cycle
has exact synonym: urea biosynthesis
has exact synonym: urea biosynthetic process
replaces: GO_0006594
replaces: GO_0006871

obsolete urea cycle intermediate metabolic process
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The chemical reactions and pathways involving any of the intermediate compounds involved in the urea cycle, a cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea.

citrulline metabolic process
type: Class
subclass of: GO_1901605
IAO_0000115: The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins.
has exact synonym: citrulline metabolism

argininosuccinate metabolic process
type: Class
subclass of: GO_0006575
subclass of: GO_0072350
subclass of: GO_1901605
IAO_0000115: The chemical reactions and pathways involving argininosuccinate, 2-(N(omega)-arginino)succinate, an intermediate in the ornithine-urea cycle, where it is synthesized from citrulline and aspartate.
has exact synonym: argininosuccinate metabolism

ribosomal subunit export from nucleus
type: Class
subclass of: GO_0031503
subclass of: GO_0033750
subclass of: GO_0051168
subclass of: GO_0051656
subclass of: part-of-parent-42254
IAO_0000115: The directed movement of a ribosomal subunit from the nucleus into the cytoplasm.
has exact synonym: ribosomal subunit export from cell nucleus
has exact synonym: ribosomal subunit export out of nucleus
has exact synonym: ribosomal subunit-nucleus export
has exact synonym: ribosomal subunit transport from nucleus to cytoplasm
has related synonym: ribosome export from nucleus

ribosomal large subunit export from nucleus
type: Class
subclass of: ribosomal subunit export from nucleus
IAO_0000115: The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm.
has related synonym: 50S ribosomal subunit export from nucleus
has related synonym: 60S ribosomal subunit export from nucleus
has exact synonym: ribosomal large subunit export from cell nucleus
has exact synonym: ribosomal large subunit export out of nucleus
has exact synonym: ribosomal large subunit-nucleus export
has exact synonym: ribosomal large subunit transport from nucleus to cytoplasm
replaces: GO_0000057

ribosomal small subunit export from nucleus
type: Class
subclass of: ribosomal subunit export from nucleus
IAO_0000115: The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm.
has related synonym: 30S ribosomal subunit export from nucleus
has related synonym: 40S ribosomal subunit export from nucleus
has exact synonym: ribosomal small subunit export from cell nucleus
has exact synonym: ribosomal small subunit export out of nucleus
has exact synonym: ribosomal small subunit-nucleus export
has exact synonym: ribosomal small subunit transport from nucleus to cytoplasm
replaces: GO_0000058

obsolete protein import into nucleus, docking
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A protein complex assembly process that contributes to protein import into the nucleus, and that results in the association of a cargo protein, a carrier protein such as an importin alpha/beta heterodimer, and a nucleoporin located at the periphery of the nuclear pore complex.

obsolete protein import into nucleus, translocation
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope.

obsolete protein import into nucleus, substrate release
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A protein complex disassembly process that contributes to protein import into the nucleus, and that results in the dissociation of the cargo protein and the carrier (such as an importin alpha/beta heterodimer) from each other and from the nuclear pore complex.

fatty-acyl-CoA binding
type: Class
subclass of: GO_0120227
subclass of: GO_1901567
IAO_0000115: Binding to a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group.
has related synonym: fatty-acyl binding
has exact synonym: fatty-acyl-coenzyme A binding

L-ornithine transmembrane transporter activity
type: Class
subclass of: GO_0008324
subclass of: GO_0008514
subclass of: GO_0015179
subclass of: part-of-parent-1903352
IAO_0000115: Enables the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid.
has related synonym: histidine/arginine/lysine/ornithine porter activity
has related synonym: L-ornithine transporter activity

obsolete DNA replication and chromosome cycle
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

mitotic sister chromatid segregation
type: Class
subclass of: sister chromatid segregation
subclass of: GO_1903047
subclass of: part-of-parent-140014
IAO_0000115: The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
has exact synonym: mitotic chromosome segregation
has related synonym: mitotic sister-chromatid adhesion release
replaces: GO_0016359

obsolete M phase specific microtubule process
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A microtubule-based process that occurs only during M phase of the cell cycle.

initial mitotic spindle pole body separation
type: Class
subclass of: GO_0110100
subclass of: GO_1903047
subclass of: part-of-parent-61804
subclass of: part-of-parent-1905047
IAO_0000115: The release of duplicated mitotic spindle pole bodies (SPBs) that begins with the nucleation of microtubules from each SPB within the nucleus, leading to V-shaped spindle microtubules. Interpolar microtubules that elongate from each pole are interconnected, forming overlapping microtubules. Capturing and antiparallel sliding apart of microtubules promotes the initial separation of the SPB.
replaces: GO_0030475

cell cycle checkpoint signaling
type: Class
subclass of: GO_0035556
subclass of: GO_1901988
IAO_0000115: A signaling process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction.
has exact synonym: cell cycle checkpoint
has related synonym: G1/S checkpoint
has related synonym: G1/S transition checkpoint
has related synonym: G2/M checkpoint
has related synonym: G2/M transition checkpoint
has exact synonym: signal transduction involved in cell cycle checkpoint
has exact synonym: signal transduction involved in G2/M transition checkpoint
replaces: GO_0031576
replaces: GO_0071779
replaces: GO_0072395
replaces: GO_0072404
replaces: GO_0072407

DNA replication checkpoint signaling
type: Class
subclass of: GO_0031570
IAO_0000115: A signal transduction process that contributes to a DNA replication checkpoint, that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.
has exact synonym: DNA replication checkpoint
has exact synonym: signal transduction involved in DNA replication checkpoint
replaces: GO_0072437

DNA damage checkpoint signaling
type: Class
subclass of: GO_0031570
subclass of: GO_0042770
IAO_0000115: A signal transduction process that contributes to a DNA damage checkpoint.
has exact synonym: DNA damage checkpoint
has related synonym: DNA damage response, signal transduction resulting in cell cycle arrest
has exact synonym: signal transduction involved in DNA damage checkpoint
replaces: GO_0072422

obsolete cytokinesis after mitosis checkpoint
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A mitotic cell cycle checkpoint that detects whether chromosome segregation is complete and negatively regulates cytokinesis following mitosis.

regulation of cyclin-dependent protein serine/threonine kinase activity
type: Class
subclass of: GO_0071900
subclass of: GO_1904029
IAO_0000115: Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.
has exact synonym: regulation of CDK activity
has related synonym: regulation of cyclin-dependent protein kinase activity

mitotic G1 phase
type: Class
subclass of: GO_0051318
subclass of: part-of-parent-51329
IAO_0000115: The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis.
has exact synonym: G1 phase of mitotic cell cycle

G1/S transition of mitotic cell cycle
type: Class
subclass of: GO_0044772
subclass of: GO_0044843
subclass of: part-of-parent-278
IAO_0000115: The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.

regulation of transcription involved in G1/S transition of mitotic cell cycle
type: Class
subclass of: GO_0006355
subclass of: GO_1903047
subclass of: part-of-parent-82
IAO_0000115: Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle.

mitotic S phase
type: Class
subclass of: GO_0051320
subclass of: part-of-parent-51329
IAO_0000115: The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle.
has exact synonym: S phase of mitotic cell cycle
has exact synonym: S-phase of mitotic cell cycle

mitotic G2 phase
type: Class
subclass of: GO_0051319
subclass of: part-of-parent-51329
IAO_0000115: The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by mitosis.
has exact synonym: G2 phase of mitotic cell cycle

G2/M transition of mitotic cell cycle
type: Class
subclass of: GO_0044772
subclass of: GO_0044839
subclass of: part-of-parent-278
IAO_0000115: The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
has exact synonym: mitotic G2/M transition

mitotic M phase
type: Class
subclass of: M phase
subclass of: GO_0098763
IAO_0000115: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle.
has exact synonym: M phase of mitotic cell cycle
has exact synonym: M-phase of mitotic cell cycle

mitotic prophase
type: Class
subclass of: GO_0051324
subclass of: part-of-parent-87
IAO_0000115: The cell cycle phase which is the first stage of M phase of mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.

mitotic metaphase
type: Class
subclass of: GO_0051323
subclass of: part-of-parent-87
IAO_0000115: The cell cycle phase, following prophase, during which chromosomes become aligned on the equatorial plate of the cell as part of a mitotic cell cycle.

mitotic anaphase
type: Class
subclass of: GO_0051322
subclass of: part-of-parent-87
IAO_0000115: The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of a mitotic cell cycle.

mitotic anaphase A
type: Class
subclass of: mitotic anaphase
IAO_0000115: The cell cycle phase during which the kinetochore microtubules shorten as chromosomes move toward the spindle poles as part of mitosis.

mitotic anaphase B
type: Class
subclass of: mitotic anaphase
IAO_0000115: The cell cycle phase during which the polar microtubules elongate and the two poles of the spindle move farther apart as part of mitosis.

mitotic telophase
type: Class
subclass of: GO_0051326
subclass of: part-of-parent-87
IAO_0000115: The cell cycle phase which follows anaphase during M phase of mitosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts.

obsolete septin assembly and septum formation
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

S-adenosyl-L-methionine transmembrane transporter activity
type: Class
subclass of: GO_0015101
subclass of: GO_1901682
subclass of: part-of-parent-1901962
IAO_0000115: Enables the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism.
has exact synonym: S-adenosylmethionine permease activity
has exact synonym: S-adenosyl methionine permease activity
has exact synonym: S-adenosylmethionine transmembrane transporter activity
has related synonym: S-adenosylmethionine transporter activity
has exact synonym: S-adenosyl methionine transporter activity
has exact synonym: SAM transmembrane transporter activity
replaces: GO_0015177

sulfur amino acid metabolic process
type: Class
subclass of: GO_0006082
subclass of: GO_0006790
subclass of: GO_1901564
IAO_0000115: The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine.
has exact synonym: sulfur amino acid metabolism
has exact synonym: sulphur amino acid metabolic process
has exact synonym: sulphur amino acid metabolism

sulfur amino acid biosynthetic process
type: Class
subclass of: sulfur amino acid metabolic process
subclass of: GO_0016053
subclass of: GO_0044272
subclass of: GO_1901566
IAO_0000115: The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine.
has exact synonym: sulfur amino acid anabolism
has exact synonym: sulfur amino acid biosynthesis
has exact synonym: sulfur amino acid formation
has exact synonym: sulfur amino acid synthesis
has exact synonym: sulphur amino acid biosynthesis
has exact synonym: sulphur amino acid biosynthetic process

sulfur amino acid catabolic process
type: Class
subclass of: sulfur amino acid metabolic process
subclass of: GO_0016054
subclass of: GO_0044273
subclass of: GO_1901565
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine.
has exact synonym: sulfur amino acid breakdown
has exact synonym: sulfur amino acid catabolism
has exact synonym: sulfur amino acid degradation
has exact synonym: sulphur amino acid catabolic process
has exact synonym: sulphur amino acid catabolism

sulfur amino acid transmembrane transporter activity
type: Class
subclass of: GO_0015171
subclass of: GO_1901682
IAO_0000115: Enables the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives.
has related synonym: sulfur amino acid transporter activity
has exact synonym: sulphur amino acid transmembrane transporter activity
has related synonym: sulphur amino acid transporter activity

S-methylmethionine transmembrane transporter activity
type: Class
subclass of: GO_0072349
subclass of: GO_1901682
subclass of: part-of-parent-15806
IAO_0000115: Enables the transfer of S-methylmethionine from one side of a membrane to the other.
has exact synonym: S-methylmethionine permease activity
has related synonym: S-methylmethionine transporter activity
replaces: GO_0015178

sulfur amino acid transport
type: Class
subclass of: GO_0006865
subclass of: GO_0072348
IAO_0000115: The directed movement of amino acids containing sulfur (cystine, methionine and their derivatives) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has exact synonym: sulphur amino acid transport

L-methionine secondary active transmembrane transporter activity
type: Class
subclass of: GO_0005294
subclass of: GO_0015191
subclass of: GO_0022853
subclass of: GO_1901680
IAO_0000115: Enables the transfer of L-methionine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
has related synonym: L-methionine porter activity

sulfate assimilation
type: Class
subclass of: GO_0006790
IAO_0000115: The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds.
has related synonym: sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor
has exact synonym: sulphate assimilation
has related synonym: sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor
replaces: GO_0019378

succinate dehydrogenase activity
type: Class
subclass of: GO_0016627
IAO_0000115: Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor.
has exact synonym: fumarate dehydrogenase activity
has exact synonym: fumarate reductase activity
has related synonym: fumaric hydrogenase activity
has exact synonym: succinate:(acceptor) oxidoreductase activity
has exact synonym: succinate:acceptor oxidoreductase activity
has exact synonym: succinate oxidoreductase activity
has exact synonym: succinic acid dehydrogenase activity
has related synonym: succinic dehydrogenase activity
has exact synonym: succinodehydrogenase activity
has exact synonym: succinyl dehydrogenase activity
replaces: GO_0019739

histidine biosynthetic process
type: Class
subclass of: GO_0006547
subclass of: GO_0008652
IAO_0000115: The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.
has exact synonym: histidine anabolism
has exact synonym: histidine biosynthesis
has exact synonym: histidine formation
has exact synonym: histidine synthesis

imidazoleglycerol-phosphate synthase activity
type: Class
subclass of: GO_0016763
IAO_0000115: Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H(+).
has related synonym: glutamine amidotransferase:cyclase activity
has exact synonym: imidazoleglycerol phosphate synthase activity
has exact synonym: imidazole glycerol phosphate synthase activity
has related synonym: imidazole-glycerol-phosphate synthase activity

obsolete repairosome
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A stable complex of proteins that carry out the DNA damage recognition and incision reactions characteristic of nucleotide excision repair (NER), such as DNA damage recognition, DNA helix unwinding, and endonucleolytic cleavage at sites flanking damaged DNA; includes TFIIH subunits and additional polypeptides; may form in the absence of DNA damage.

nucleotide-excision repair complex
type: Class
subclass of: GO_0140513
IAO_0000115: Any complex formed of proteins that act in nucleotide-excision repair.
has related synonym: UvrBC complex
has related synonym: UvrB-UvrC complex

nucleotide-excision repair factor 1 complex
type: Class
subclass of: nucleotide-excision repair complex
IAO_0000115: One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively.
has exact synonym: NEF1 complex
has exact synonym: XPA-ERCC1-ERCC4 complex

nucleotide-excision repair factor 2 complex
type: Class
subclass of: nucleotide-excision repair complex
IAO_0000115: One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p.
has exact synonym: NEF2 complex

nucleotide-excision repair factor 3 complex
type: Class
subclass of: nucleotide-excision repair complex
IAO_0000115: One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, Tfb4p and Tfb5p. Note that Ssl2p is also called Rad25p).
has exact synonym: NEF3 complex

nucleotide-excision repair factor 4 complex
type: Class
subclass of: nucleotide-excision repair complex
IAO_0000115: One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and DNA-dependent ATPase activities. In S. cerevisiae, it is composed of Rad7p and Rad16p.
has exact synonym: NEF4 complex

obsolete regulation of transcription involved in G1 phase of mitotic cell cycle
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any process that regulates transcription such that the target genes are transcribed as part of the G1 phase of the mitotic cell cycle.

obsolete regulation of transcription involved in S phase of mitotic cell cycle
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A cell cycle process that regulates transcription such that the target genes are transcribed as part of the S phase of the mitotic cell cycle.

obsolete regulation of transcription involved in G2-phase of mitotic cell cycle
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any process that regulates transcription such that the target genes are transcribed as part of the G2 phase of the mitotic cell cycle.

regulation of transcription involved in G2/M transition of mitotic cell cycle
type: Class
subclass of: GO_0006355
subclass of: GO_1903047
subclass of: part-of-parent-86
IAO_0000115: Any process that regulates transcription such that the target genes are transcribed as part of the G2/M transition of the mitotic cell cycle.
has related synonym: G2/M-specific transcription in mitotic cell cycle
has related synonym: regulation of transcription from RNA polymerase II promoter during G2/M transition of mitotic cell cycle

histone deacetylase complex
type: Class
subclass of: GO_0140513
subclass of: GO_1902494
subclass of: part-of-parent-5654
IAO_0000115: A protein complex that possesses histone deacetylase activity.
has exact synonym: HDAC complex

RNA polymerase I transcription regulator complex
type: Class
subclass of: GO_0005667
subclass of: GO_0140513
subclass of: part-of-parent-5730
IAO_0000115: A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase I.
has related synonym: RNA polymerase I transcription factor complex

glycerol-1-phosphatase activity
type: Class
subclass of: GO_0016791
IAO_0000115: Catalysis of the reaction: glycerol-1-phosphate + H2O = glycerol + phosphate.
has related synonym: alpha-glycerol phosphatase activity
has related synonym: alpha-glycerophosphatase activity
has related synonym: glycerol-1-phosphate phosphohydrolase activity
has related synonym: glycerol 3-phosphatase activity
has related synonym: glycerol-3-phosphate phosphatase activity
has related synonym: glycerol 3-phosphate phosphohydrolase activity

negative regulation of transcription by RNA polymerase II
type: Class
subclass of: GO_0006357
subclass of: GO_0045892
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
has related synonym: downregulation of global transcription from RNA polymerase II promoter
has related synonym: down regulation of global transcription from RNA polymerase II promoter
has related synonym: down-regulation of global transcription from RNA polymerase II promoter
has exact synonym: downregulation of transcription from RNA polymerase II promoter
has exact synonym: down regulation of transcription from RNA polymerase II promoter
has exact synonym: down-regulation of transcription from RNA polymerase II promoter
has related synonym: inhibition of global transcription from RNA polymerase II promoter
has exact synonym: inhibition of transcription from RNA polymerase II promoter
has related synonym: negative regulation of gene-specific transcription from RNA polymerase II promoter
has related synonym: negative regulation of global transcription from Pol II promoter
has exact synonym: negative regulation of transcription from Pol II promoter
has exact synonym: negative regulation of transcription from RNA polymerase II promoter
has related synonym: negative regulation of transcription from RNA polymerase II promoter, global
replaces: GO_0010553
replaces: GO_0045816

histone acetyltransferase complex
type: Class
subclass of: GO_0031248
subclass of: GO_0140513
subclass of: part-of-parent-5654
IAO_0000115: A protein complex that possesses histone acetyltransferase activity.
has exact synonym: histone acetylase complex

SAGA complex
type: Class
subclass of: GO_0070461
subclass of: GO_1905368
IAO_0000115: A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695).
has related synonym: PCAF complex
has related synonym: PCAF histone acetylase-associated complex
has related synonym: SPT3-TAF9-GCN5 acetylase complex
has related synonym: SPT3-TAF9-PCAF acetylase complex
has exact synonym: Spt-Ada-Gcn5-acetyltransferase complex
has related synonym: STAGA coactivator complex
has related synonym: STAGA complex
replaces: GO_0000125
replaces: GO_0030914

transcription factor TFIIIB complex
type: Class
subclass of: GO_0090576
IAO_0000115: A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF.

transcription factor TFIIIC complex
type: Class
subclass of: GO_0090576
IAO_0000115: A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions.

flocculation
type: Class
subclass of: GO_0051703
subclass of: GO_0098610
IAO_0000115: The reversible, non-sexual aggregation of single-celled organisms in suspension to form aggregates of many cells known as flocs.
has exact synonym: cell-cell adhesion involved in flocculation
has related synonym: cell-cell adhesion involved in flocculation via cell wall protein-carbohydrate interaction
has related synonym: coflocculation
has related synonym: co-flocculation
has related synonym: coflocculation via lectin-mannose interaction
has related synonym: coflocculation via protein-carbohydrate interaction
has related synonym: flocculation via cell wall protein-carbohydrate interaction
has related synonym: flocculation via extracellular polymer
replaces: GO_0000501
replaces: GO_0032128
replaces: GO_0036281
replaces: GO_0036282
replaces: GO_0043689
replaces: GO_0043690

incipient cellular bud site
type: Class
subclass of: GO_0140535
IAO_0000115: The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence.

establishment of mitotic spindle orientation
type: Class
subclass of: GO_0040001
subclass of: GO_0051294
subclass of: part-of-parent-278
IAO_0000115: A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
has related synonym: establishment of spindle orientation during mitosis
has exact synonym: establishment of spindle orientation involved in mitotic cell cycle
has exact synonym: mitotic spindle orientation
has exact synonym: orienting of mitotic spindle
replaces: GO_0030607
replaces: GO_0030609

polarisome
type: Class
subclass of: GO_0032991
subclass of: part-of-parent-5938
subclass of: part-of-parent-30427
IAO_0000115: Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p.

mannan polymerase complex
type: Class
subclass of: GO_0031501
subclass of: GO_0098796
subclass of: part-of-parent-137
subclass of: part-of-parent-30173
IAO_0000115: A protein complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins.
has exact synonym: alpha-1,6-mannosyltransferase complex

Golgi cis cisterna
type: Class
subclass of: GO_0031985
IAO_0000115: The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER.

Golgi trans cisterna
type: Class
subclass of: GO_0031985
IAO_0000115: The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed.
has related synonym: late Golgi

Golgi membrane
type: Class
subclass of: GO_0098588
subclass of: part-of-parent-5794
IAO_0000115: The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

acylglycerone-phosphate reductase activity
type: Class
subclass of: GO_0016616
IAO_0000115: Catalysis of the reaction: 1-palmitoylglycerol-3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H(+).
has exact synonym: 1-acyldihydroxyacetone-phosphate reductase activity
has related synonym: 1-palmitoylglycerol-3-phosphate:NADP+ oxidoreductase activity
has related synonym: acyldihydroxyacetone phosphate reductase activity
has related synonym: palmitoyldihydroxyacetone-phosphate reductase activity
has related synonym: palmitoyl dihydroxyacetone phosphate reductase activity
has related synonym: palmitoyl-dihydroxyacetone-phosphate reductase activity

cellular bud neck contractile ring
type: Class
subclass of: GO_0110085
subclass of: part-of-parent-5935
IAO_0000115: A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane at the mother-bud neck in mitotic cells that divide by budding in preparation for completing cytokinesis. An example of this structure is found in Saccharomyces cerevisiae.
has exact synonym: neck ring

cellular bud neck septin ring
type: Class
subclass of: cellular bud neck septin structure
subclass of: GO_0005940
subclass of: GO_0032161
subclass of: part-of-parent-5935
IAO_0000115: A ring-shaped structure that forms at the site of cytokinesis in the bud neck of a budding cell; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange.

exocyst
type: Class
subclass of: GO_0099023
subclass of: part-of-parent-5938
IAO_0000115: A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals.
has exact synonym: exocyst complex
has exact synonym: Sec6/8 complex

microfilament motor activity
type: Class
subclass of: cytoskeletal motor activity
subclass of: GO_0140657
IAO_0000115: A motor activity that generates movement along a microfilament, driven by ATP hydrolysis.
has exact synonym: actin-activated ATPase activity
has exact synonym: actin-dependent ATPase activity
has exact synonym: actin filament motor activity
has exact synonym: actin-filament motor activity
has related synonym: muscle motor activity
has related synonym: myosin ATPase activity
replaces: GO_0030898

actin cortical patch assembly
type: Class
subclass of: GO_0022607
subclass of: GO_0030866
subclass of: GO_0044396
IAO_0000115: Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells.

1,3-beta-D-glucan synthase complex
type: Class
subclass of: GO_0098797
subclass of: GO_1990234
IAO_0000115: A protein complex that catalyzes the transfer of a glucose group from UDP-glucose to a (1->3)-beta-D-glucan chain.
has exact synonym: (1->3)-beta-glucan synthase complex
has exact synonym: 1,3-beta-glucan synthase complex

SNARE binding
type: Class
subclass of: GO_0005515
IAO_0000115: Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
has exact synonym: SNAP receptor binding

DNA strand exchange activity
type: Class
subclass of: GO_0140097
subclass of: part-of-parent-6310
IAO_0000115: Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA.
has related synonym: RecA-family recombinase activity
has exact synonym: recombinase activity
has related synonym: strand exchange activity
has related synonym: strand transferase

ubiquitin ligase complex
type: Class
subclass of: GO_0140535
subclass of: GO_1990234
IAO_0000115: A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.

nuclear ubiquitin ligase complex
type: Class
subclass of: ubiquitin ligase complex
subclass of: GO_0140513
subclass of: part-of-parent-5634
IAO_0000115: A ubiquitin ligase complex found in the nucleus.

cytoplasmic ubiquitin ligase complex
type: Class
subclass of: ubiquitin ligase complex
subclass of: part-of-parent-5737
IAO_0000115: A ubiquitin ligase complex found in the cytoplasm.

rRNA modification
type: Class
subclass of: GO_0006364
subclass of: GO_0009451
IAO_0000115: The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically.
has related synonym: rRNA editing
replaces: GO_0016548

phosphorelay sensor kinase activity
type: Class
subclass of: protein histidine kinase activity
subclass of: GO_0140299
subclass of: part-of-parent-160
IAO_0000115: Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
has related synonym: two-component sensor activity
has related synonym: two-component sensor molecule
has related synonym: two-component system sensor activity

phosphorelay response regulator activity
type: Class
subclass of: GO_0060089
subclass of: part-of-parent-160
IAO_0000115: Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
has related synonym: two-component response regulator activity

protein phosphatase type 2A complex
type: Class
subclass of: GO_0008287
IAO_0000115: A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit.
has exact synonym: PP2A complex
has related synonym: PP2A-pi
has related synonym: PP2a-protector
has related synonym: protein phosphatase 2 complex

phosphorelay signal transduction system
type: Class
subclass of: GO_0035556
IAO_0000115: A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
has exact synonym: histidyl-aspartyl phosphorelay

osmosensory signaling MAPK cascade
type: Class
subclass of: GO_0007231
subclass of: GO_0051403
IAO_0000115: The series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays a signal, containing at least a Hog1/Sty1 family MAPK, a Pbs2/Wis1 family MAPKK and a Ssk2/Win1 family MAP3K.
has related synonym: activation of MAPK activity involved in osmosensory signaling pathway
has related synonym: activation of MAPKK activity during osmolarity sensing
has related synonym: activation of MAPKK activity involved in osmosensory signaling pathway
has related synonym: activation of MAPKKK activity during osmolarity sensing
has related synonym: activation of MAPKKK activity involved in osmosensory signaling pathway
has related synonym: activation of Pbs2 kinase
has related synonym: High Osmolarity Glycerol (HOG) MAPK pathway
has related synonym: Hog1/Sty1 stress-activated MAPK cascade
has related synonym: Hog1 MAPK pathway
has related synonym: inactivation of MAPK activity involved in osmosensory signaling pathway
has exact synonym: MAPK cascade involved in osmosensory signaling pathway
has exact synonym: MAPKKK cascade during osmolarity sensing
has exact synonym: MAPKKK cascade involved in osmosensory signaling pathway
has exact synonym: MAPKKK cascade involved in osmosensory signalling pathway
has related synonym: osmolarity sensing, activation of MAPK activity
has related synonym: osmolarity sensing, activation of MAP kinase kinase activity
has related synonym: osmolarity sensing, activation of MAP kinase kinase kinase activity
has related synonym: osmolarity sensing, activation of MAPKK activity
has related synonym: osmolarity sensing, activation of MAPKKK activity
has exact synonym: osmolarity sensing, MAPKKK cascade
has related synonym: termination of MAPK activity during osmolarity sensing
replaces: GO_0000167
replaces: GO_0000168
replaces: GO_0000169
replaces: GO_0000173
replaces: GO_0007233

tryptophan biosynthetic process
type: Class
subclass of: GO_0006568
subclass of: GO_0009073
subclass of: GO_0046219
subclass of: GO_1901607
IAO_0000115: The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate.
has exact synonym: aromatic amino acid family biosynthetic process, anthranilate pathway
has exact synonym: tryptophan anabolism
has exact synonym: tryptophan biosynthesis
has exact synonym: tryptophan formation
has exact synonym: tryptophan synthesis
replaces: GO_0009096

protein phosphatase type 1 complex
type: Class
subclass of: GO_0008287
subclass of: part-of-parent-5737
IAO_0000115: A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity.

MAPK cascade
type: Class
subclass of: GO_0035556
IAO_0000115: An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
has related synonym: ERK/MAPK cascade
has exact synonym: MAP kinase cascade
has exact synonym: MAP kinase kinase kinase cascade
has exact synonym: MAPKKK cascade
has related synonym: MAPKKK cascade during sporulation
has related synonym: MAPK signaling
has related synonym: MAPK signalling
has exact synonym: MAPK signal transduction
has exact synonym: mitogen-activated protein kinase cascade
replaces: GO_0007255

nucleotide binding
type: Class
subclass of: GO_0036094
subclass of: GO_1901265
IAO_0000115: Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

sphingosine hydroxylase activity
type: Class
subclass of: GO_0016491
IAO_0000115: Catalysis of the hydroxylation of sphingolipid long chain bases.

ribonuclease MRP activity
type: Class
subclass of: endoribonuclease activity
IAO_0000115: Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA.
has exact synonym: RNase MRP

ribonuclease MRP complex
type: Class
subclass of: GO_0005732
subclass of: GO_1902555
IAO_0000115: A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication.
has exact synonym: ribonuclease mitochondrial RNA processing complex
has exact synonym: RNase MRP complex

obsolete inactivation of MAPK (mating sensu Saccharomyces)
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Downregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces.

3'-5'-exoribonuclease activity
type: Class
subclass of: GO_0008408
subclass of: GO_0016896
IAO_0000115: Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
has exact synonym: 3'-5' exoribonuclease activity

nuclear exosome (RNase complex)
type: Class
subclass of: exosome (RNase complex)
subclass of: GO_0140513
subclass of: part-of-parent-5634
subclass of: part-of-parent-31981
IAO_0000115: A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
has exact synonym: eukaryotic exosome multienzyme ribonuclease complex
has exact synonym: nuclear exosome (ribonuclease complex)
has exact synonym: nuclear exosome multienzyme ribonuclease complex

cytoplasmic exosome (RNase complex)
type: Class
subclass of: exosome (RNase complex)
subclass of: part-of-parent-5737
IAO_0000115: A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
has exact synonym: cytoplasmic exosome (ribonuclease complex)
has exact synonym: cytoplasmic exosome multienzyme ribonuclease complex
has exact synonym: prokaryotic exosome multienzyme ribonuclease complex

exosome (RNase complex)
type: Class
subclass of: GO_1905354
subclass of: part-of-parent-5622
IAO_0000115: A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
has exact synonym: exosome (ribonucleasease complex)
has exact synonym: exosome multienzyme ribonuclease complex

rRNA (adenine-N6,N6-)-dimethyltransferase activity
type: Class
subclass of: GO_0008170
subclass of: GO_0016433
IAO_0000115: Catalysis of the dimethylation of two adjacent adenine residues in a rRNA, using S-adenosyl-L-methionine as a methyl donor.
has exact synonym: 18S rRNA dimethylase activity
has exact synonym: dimethyladenosine transferase activity
has exact synonym: S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase activity
replaces: GO_0043790

obsolete cytosolic large ribosomal subunit
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete cytosolic small ribosomal subunit
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

rDNA binding
type: Class
subclass of: GO_1990837
IAO_0000115: Binding to a DNA sequence encoding a ribosomal RNA.
has exact synonym: ribosomal DNA binding

rDNA heterochromatin assembly
type: Class
subclass of: GO_0140718
subclass of: part-of-parent-1990700
IAO_0000115: The assembly of chromatin characterized by the modified histone H3K9me3, into heterochromatin, resulting in the repression of transcription of rDNA.
has related synonym: chromatin silencing at rDNA
has related synonym: chromatin silencing at ribosomal DNA
has related synonym: heterochromatic silencing at rDNA
has related synonym: rDNA chromatin silencing

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
type: Class
subclass of: nuclear-transcribed mRNA catabolic process
IAO_0000115: The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
has exact synonym: mRNA breakdown, nonsense-mediated decay
has exact synonym: mRNA catabolic process, nonsense-mediated
has exact synonym: mRNA catabolism, nonsense-mediated
has exact synonym: mRNA degradation, nonsense-mediated decay
has exact synonym: nonsense-mediated mRNA decay
has exact synonym: nuclear mRNA catabolic process, nonsense-mediated decay

obsolete activation of MAPKKK activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase (MAPKKK).

obsolete activation of MAPKK activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK).

obsolete activation of MAPK activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The initiation of the activity of the inactive enzyme MAP kinase (MAPK).

obsolete inactivation of MAPK activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any process that terminates the activity of the active enzyme MAP kinase.

obsolete MAPK import into nucleus
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The directed movement of a MAP kinase to the nucleus upon activation.

obsolete MAPKKK cascade (pseudohyphal growth)
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. MAPKKK cascade involved in transduction of signal promoting pseudohyphal or invasive growth.

obsolete activation of MAPKKK (pseudohyphal growth)
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Upregulation of MAPKKK activity in the context of regulating pseudohyphal or invasive growth.

obsolete activation of MAPKK (pseudohyphal growth)
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Upregulation of a MAP kinase kinase in the context of regulating pseudohyphal or invasive growth.

obsolete activation of MAPK (pseudohyphal growth)
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Upregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth.

obsolete inactivation of MAPK (pseudohyphal growth)
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Downregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth.

obsolete nuclear translocation of MAPK (pseudohyphal growth)
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Movement of a MAP kinase to the nucleus in the context of regulating pseudohyphal or invasive growth.

cell wall integrity MAPK cascade
type: Class
subclass of: GO_0051403
subclass of: part-of-parent-71554
IAO_0000115: A MAPK cascade that contributes to cell wall organization or biogenesis.
has exact synonym: cell integrity MAPK pathway
has exact synonym: cell wall biogenesis, MAPKKK cascade
has related synonym: MAPK cascade involved in cell wall biogenesis
has exact synonym: MAPK cascade involved in cell wall organization or biogenesis
has exact synonym: MAPKKK cascade involved in cell wall biogenesis
has related synonym: Mpk1 cascade
has related synonym: Pmk1 MAPK cell integrity signaling
has related synonym: PMK1-MAPK signal transduction pathway
has related synonym: Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway
has related synonym: Slt2 cascade

obsolete activation of MAPKKK activity involved in cell wall organization or biogenesis
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of cell wall organization or biogenesis.

obsolete activation of MAPKK activity involved in cell wall organization or biogenesis
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of cell wall organization or biogenesis.

obsolete activation of MAPK activity involved in cell wall organization or biogenesis
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells.

obsolete inactivation of MAPK activity involved in cell wall organization or biogenesis
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any process that terminates the activity of the active enzyme MAP kinase in the context of cell wall organization or biogenesis.

obsolete MAPK import into nucleus involved in cell wall organization or biogenesis
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The directed movement of a MAP kinase to the nucleus that occurs in the context of cell wall organization or biogenesis.

obsolete MAPKKK cascade during sporulation (sensu Saccharomyces)
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. MAPKKK cascade involved in transduction of signal promoting sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930).

obsolete activation of MAPKKK during sporulation (sensu Saccharomyces)
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Upregulation of MAPKKK activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930).

obsolete activation of MAPKK during sporulation (sensu Saccharomyces)
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Upregulation of a MAP kinase kinase in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930).

obsolete activation of MAPK during sporulation (sensu Saccharomyces)
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Upregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930).

obsolete inactivation of MAPK during sporulation (sensu Saccharomyces)
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Downregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930).

obsolete nuclear translocation of MAPK during sporulation (sensu Saccharomyces)
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Movement of a MAP kinase to the nucleus in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930).

obsolete MAPK import into nucleus involved in osmosensory signaling pathway
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The directed movement of a MAP kinase to the nucleus during osmolarity sensing.

protein polyubiquitination
type: Class
subclass of: GO_0016567
IAO_0000115: Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
has related synonym: polyubiquitin
has exact synonym: protein polyubiquitinylation
has exact synonym: protein polyubiquitylation

NAD+ diphosphatase activity
type: Class
subclass of: dinucleotide phosphatase activity
IAO_0000115: Catalysis of the reaction: NAD+ + H2O = AMP + NMN.
has exact synonym: NAD(+) pyrophosphatase activity
has exact synonym: NAD+ phosphohydrolase activity
has exact synonym: NAD+ pyrophosphatase activity
has related synonym: NAD diphosphatase activity
has related synonym: NADP pyrophosphatase activity
has related synonym: NAD pyrophosphatase activity
has related synonym: nicotinamide adenine dinucleotide pyrophosphatase activity

obsolete protein degradation tagging activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Covalent addition of polyubiquitin to another protein, targeting the tagged protein for destruction.

meiotic spindle organization
type: Class
subclass of: GO_0007051
subclass of: GO_1903046
subclass of: part-of-parent-51321
IAO_0000115: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle.
has exact synonym: meiotic spindle organisation
has related synonym: meiotic spindle organization and biogenesis
has related synonym: meiotic spindle stabilization
has exact synonym: spindle organization during meiosis
replaces: GO_0043147

tRNA-intron endonuclease activity
type: Class
subclass of: tRNA-specific ribonuclease activity
subclass of: GO_0016892
IAO_0000115: Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.
has related synonym: splicing endonuclease activity
has related synonym: transfer ribonucleate intron endoribonuclease activity
has related synonym: transfer splicing endonuclease activity
has exact synonym: tRNA-intron endoribonuclease activity
has related synonym: tRNA splicing endonuclease activity
has related synonym: tRNA-splicing endonuclease activity
has related synonym: tRNATRPintron endonuclease activity

tRNA-intron endonuclease complex
type: Class
subclass of: GO_0140513
subclass of: GO_1902555
IAO_0000115: A protein complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.
has exact synonym: SEN complex
has exact synonym: tRNA splicing endonuclease complex

tRNA 2'-phosphotransferase activity
type: Class
subclass of: GO_0016773
subclass of: GO_0140101
IAO_0000115: Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate.
has related synonym: 2'-phospho-[ligated tRNA]:NAD+ phosphotransferase activity
has related synonym: 2'-phosphotransferase activity
has related synonym: 2'-phospho-tRNA:NAD+ phosphotransferase activity
has related synonym: Tpt1
has related synonym: Tpt1p
has related synonym: yeast 2'-phosphotransferase activity
replaces: GO_0008665

obsolete M/G1 transition of mitotic cell cycle
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Progression from M phase to G1 phase of the mitotic cell cycle.

DNA secondary structure binding
type: Class
subclass of: DNA binding
IAO_0000115: Binding to a DNA secondary structure element such as a four-way junction, a bubble, a loop, Y-form DNA, or a double-strand/single-strand junction.

obsolete vacuolar hydrogen-transporting ATPase
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

vacuolar proton-transporting V-type ATPase, V0 domain
type: Class
subclass of: GO_0033179
subclass of: part-of-parent-5774
subclass of: part-of-parent-16471
IAO_0000115: The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.
has exact synonym: vacuolar hydrogen ion-transporting ATPase V0 domain

vacuolar proton-transporting V-type ATPase, V1 domain
type: Class
subclass of: GO_0033180
subclass of: part-of-parent-5773
subclass of: part-of-parent-16471
IAO_0000115: The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.
has exact synonym: vacuolar hydrogen ion-transporting ATPase V1 domain

plasma membrane proton-transporting V-type ATPase, V0 domain
type: Class
subclass of: GO_0033179
subclass of: GO_0098797
subclass of: part-of-parent-5886
subclass of: part-of-parent-5887
subclass of: part-of-parent-33181
IAO_0000115: The V0 domain of a proton-transporting V-type ATPase found in the plasma membrane.
has exact synonym: plasma membrane hydrogen ion-transporting ATPase V0 domain

plasma membrane proton-transporting V-type ATPase, V1 domain
type: Class
subclass of: GO_0033180
subclass of: GO_0098797
subclass of: part-of-parent-5886
subclass of: part-of-parent-5887
subclass of: part-of-parent-33181
IAO_0000115: The V1 domain of a proton-transporting V-type ATPase found in the plasma membrane.
has exact synonym: plasma membrane hydrogen ion-transporting ATPase V1 domain

peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity
type: Class
subclass of: GO_0016811
IAO_0000115: Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue.
has related synonym: glycopeptidase activity
has related synonym: glycopeptide N-glycosidase activity
has related synonym: jack-bean glycopeptidase
has related synonym: N-glycanase activity
has related synonym: N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase activity
has related synonym: N-oligosaccharide glycopeptidase activity
has related synonym: peptide:N-glycanase
has exact synonym: PNGase
has related synonym: PNGase A
has related synonym: PNGase F

N-acetylglucosaminylphosphatidylinositol deacetylase activity
type: Class
subclass of: GO_0016811
subclass of: GO_0019213
IAO_0000115: Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. This reaction is the second step of the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane.
has related synonym: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol acetylhydrolase activity
has related synonym: acetylglucosaminylphosphatidylinositol deacetylase activity
has related synonym: GlcNAc-PI deacetylase activity
has related synonym: GlcNAc-PI de-N-acetylase activity
has related synonym: N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase activity
has related synonym: N-acetylglucosaminylphosphatidylinositol de-N-acetylase activity

microtubule cytoskeleton organization
type: Class
subclass of: GO_0007010
subclass of: GO_0007017
IAO_0000115: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
has exact synonym: microtubule cytoskeleton organisation
has related synonym: microtubule cytoskeleton organization and biogenesis
has exact synonym: microtubule dynamics

oxaloacetate secondary active transmembrane transporter activity
type: Class
subclass of: GO_0015131
subclass of: GO_0015291
subclass of: GO_0022853
IAO_0000115: Enables the transfer of oxaloacetate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
has related synonym: oxaloacetate carrier activity

nuclear chromosome
type: Class
subclass of: GO_0005694
subclass of: part-of-parent-5634
subclass of: part-of-parent-31981
IAO_0000115: A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.
has related synonym: nuclear interphase chromosome

obsolete cytoplasmic chromosome
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A chromosome found in the cytoplasm.

obsolete nuclear mitotic chromosome
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A chromosome found in the nucleus during mitosis.

obsolete cytoplasmic mitotic chromosome
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A chromosome found in the cytoplasm during mitosis.

obsolete nuclear interphase chromosome
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A chromosome found in the nucleus during interphase.

obsolete cytoplasmic interphase chromosome
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A chromosome found in the cytoplasm during interphase.

phosphoethanolamine N-methyltransferase activity
type: Class
subclass of: GO_0008170
subclass of: GO_0008757
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate.
has related synonym: phosphoethanolamine methyltransferase activity
has related synonym: S-adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase activity

astral microtubule
type: Class
subclass of: GO_0005876
subclass of: GO_0005881
subclass of: part-of-parent-5818
IAO_0000115: Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell.

mitotic prometaphase
type: Class
subclass of: GO_0098763
IAO_0000115: The cell cycle phase in higher eukaryotes which follows mitotic prophase and during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles.

leptotene
type: Class
subclass of: GO_0098764
subclass of: part-of-parent-7128
IAO_0000115: The cell cycle phase which is the first stage of prophase I in meiosis, and during which the chromosomes first become visible.

zygotene
type: Class
subclass of: GO_0098764
subclass of: part-of-parent-7128
IAO_0000115: The cell cycle phase which follows leptotene during prophase I of meiosis, and during which each chromosome pairs with its homolog; the two become aligned and crossing over may occur.

pachytene
type: Class
subclass of: GO_0098764
subclass of: part-of-parent-7128
IAO_0000115: The cell cycle phase which follows zygotene during prophase I of meiosis, and during which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome.

diplotene
type: Class
subclass of: GO_0098764
subclass of: part-of-parent-7128
IAO_0000115: The cell cycle phase which follows pachytene during prophase I of meiosis, during which the homologous chromosomes begin to separate and the synaptonemal complex dissolves.

diakinesis
type: Class
subclass of: GO_0098764
subclass of: part-of-parent-7128
IAO_0000115: The cell cycle phase which follows diplotene during prophase I of meiosis, the separation of homologous chromosomes is complete and crossing over has occurred.

pericentriolar material
type: Class
subclass of: GO_0110165
subclass of: part-of-parent-5813
IAO_0000115: A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome.

commitment complex
type: Class
subclass of: GO_0005684
IAO_0000115: A spliceosomal complex that is formed by association of the U1 snRNP with the 5' splice site of an unspliced intron in an RNA transcript.
has related synonym: mammalian spliceosomal complex E
has related synonym: mammalian spliceosomal E complex
has related synonym: yeast spliceosomal complex CC

spliceosomal tri-snRNP complex assembly
type: Class
subclass of: spliceosomal snRNP assembly
IAO_0000115: The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex.
has exact synonym: assembly of spliceosomal tri-snRNP
has related synonym: assembly of spliceosomal tri-snRNP U4/U6.U5
has related synonym: assembly of spliceosomal tri-snRNP U4atac/U6atac.U5
has related synonym: snRNP recycling
has exact synonym: spliceosomal tri-snRNP assembly
has related synonym: spliceosomal tri-snRNP U4/U6.U5 assembly
has related synonym: spliceosomal tri-snRNP U4atac/U6atac.U5 assembly
replaces: GO_0000351
replaces: GO_0000355

spliceosomal complex assembly
type: Class
subclass of: GO_0022618
subclass of: part-of-parent-398
IAO_0000115: The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions.
has related synonym: spliceosome assembly

delta24(24-1) sterol reductase activity
type: Class
subclass of: GO_0016628
IAO_0000115: Catalysis of the reaction: ergosterol + NADP(+) = ergosta-5,7,22,24(24(1))-tetraen-3beta-ol + H(+) + NADPH.
has related synonym: C-24(28) sterol reductase activity
has exact synonym: D24(24-1)-sterol reductase activity
has related synonym: delta24(241)-sterol reductase activity
has related synonym: ergosterol:NADP+ delta24(241)-oxidoreductase activity
has related synonym: sterol Delta(24(28))-methylene reductase activity
has related synonym: sterol Delta(24(28))-reductase activity
has related synonym: sterol delta24(28)-methylene reductase activity
has exact synonym: sterol delta-24(28) methylene reductase activity
has related synonym: sterol delta24(28)-reductase activity
has exact synonym: sterol delta-24(28) reductase activity

C-8 sterol isomerase activity
type: Class
subclass of: GO_0016863
IAO_0000115: Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols.
has exact synonym: delta-8-delta-7 sterol isomerase activity

C-5 sterol desaturase activity
type: Class
subclass of: GO_0016717
subclass of: GO_0070704
IAO_0000115: Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+.
has exact synonym: sterol-C5-desaturase activity

C-22 sterol desaturase activity
type: Class
subclass of: GO_0016717
subclass of: GO_0070704
IAO_0000115: Catalysis of the formation of the C-22(23) double bond in the sterol side chain. An example reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+.

lanosterol synthase activity
type: Class
subclass of: GO_0031559
IAO_0000115: Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus.
has related synonym: (S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming)
has related synonym: 2,3-epoxysqualene lanosterol cyclase activity
has exact synonym: 2,3-epoxysqualene-lanosterol cyclase activity
has related synonym: 2,3-epoxysqualene--lanosterol cyclase activity
has related synonym: 2,3-oxidosqualene-lanosterol cyclase activity
has related synonym: 2,3-oxidosqualene sterol cyclase activity
has related synonym: lanosterol 2,3-oxidosqualene cyclase activity
has exact synonym: OSC
has exact synonym: oxidosqualene:lanosterol cyclase activity
has exact synonym: oxidosqualene-lanosterol cyclase activity
has related synonym: oxidosqualene--lanosterol cyclase activity
has related synonym: squalene 2,3-epoxide:lanosterol cyclase activity
has related synonym: squalene-2,3-oxide-lanosterol cyclase activity
has related synonym: squalene epoxidase-cyclase activity

C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
type: Class
subclass of: GO_0016616
IAO_0000115: Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H.
has related synonym: 3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)
has exact synonym: 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)
has related synonym: 3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)
has related synonym: 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity
has related synonym: C-3 sterol dehydrogenase (C-4 decarboxylase) activity
has related synonym: C-3 sterol dehydrogenase activity
has related synonym: sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
has related synonym: sterol 4alpha-carboxylic decarboxylase activity
has related synonym: sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity

3-keto sterol reductase activity
type: Class
subclass of: GO_0016616
IAO_0000115: Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H(+).
has related synonym: 3beta-hydroxy-steroid:NADP+ 3-oxidoreductase
has exact synonym: 3-keto-steroid reductase activity
has related synonym: 3-KSR activity
replaces: GO_0050576

C-4 methylsterol oxidase activity
type: Class
subclass of: GO_0016716
IAO_0000115: Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H+ + 3 O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O.
has exact synonym: 4-methylsterol oxidase activity
has related synonym: methylsterol hydroxylase activity
has related synonym: methylsterol monooxygenase activity

allantoin metabolic process
type: Class
subclass of: GO_0043603
subclass of: GO_0046483
subclass of: GO_1901360
subclass of: GO_1901564
IAO_0000115: The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism.
has exact synonym: allantoin metabolism

allantoin catabolic process
type: Class
subclass of: allantoin metabolic process
subclass of: GO_0043605
subclass of: GO_0046700
subclass of: GO_1901361
subclass of: GO_1901565
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea.
has exact synonym: allantoin breakdown
has exact synonym: allantoin catabolism
has exact synonym: allantoin degradation

nitrilase activity
type: Class
subclass of: GO_0016815
IAO_0000115: Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides.
has related synonym: acetonitrilase activity
has related synonym: benzonitrilase activity
has related synonym: nitrile aminohydrolase activity

obsolete isoleucine/valine:sodium symporter activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: (isoleucine or valine)(out) + Na+(out) = (isoleucine or valine)(in) + Na+(in).

obsolete intracellular nucleoside transmembrane transporter activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Enables the directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide) within a cell.

obsolete hydrogen-translocating V-type ATPase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: ATP + H2O + H(+)(in) = ADP + phosphate + H+(out). Found in vacuoles of eukaryotes and in bacteria.

obsolete sodium-translocating V-type ATPase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in vacuoles of eukaryotes and in bacteria.

mitochondrial chromosome
type: Class
subclass of: GO_0005694
subclass of: part-of-parent-5739
subclass of: part-of-parent-42645
IAO_0000115: A chromosome found in the mitochondrion of a eukaryotic cell.
has related synonym: mitochondrial DNA
has related synonym: mitochondrial genome
has related synonym: mtDNA

obsolete heterotrimeric G-protein GTPase, alpha-subunit
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Subunit of a heterotrimeric G-protein GTPase that contains the guanine nucleotide binding site and possesses GTPase activity.

obsolete heterotrimeric G-protein GTPase, beta-subunit
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Subunit of a heterotrimeric G-protein GTPase; associates tightly with the gamma subunit.

obsolete heterotrimeric G-protein GTPase, gamma-subunit
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Smallest subunit of a heterotrimeric G-protein GTPase; associates tightly with the beta subunit.

mitochondrial fission
type: Class
subclass of: GO_0007005
subclass of: GO_0048285
IAO_0000115: The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.
has exact synonym: mitochondrial division
has related synonym: mitochondrial proliferation

obsolete cell fraction
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A generic term for parts of cells prepared by disruptive biochemical techniques.

peroxisome targeting sequence binding
type: Class
subclass of: GO_0005048
IAO_0000115: Binding to a peroxisomal targeting sequence, a sequence of amino acids within a protein that acts as a signal for the localization of a protein into the peroxisome.
has related synonym: peroxisome targeting signal receptor
has exact synonym: PTS binding
has related synonym: PTS receptor
replaces: GO_0005051

toxin export channel activity
type: Class
subclass of: GO_0015288
subclass of: GO_0019534
IAO_0000115: Enables the energy independent passage of toxins, sized less than 1000 Da, across a membrane towards the outside of the cell. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.

peptidoglycan metabolic process
type: Class
subclass of: GO_0030203
IAO_0000115: The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of strands of glycosaminoglycan cross-linked by oligopeptides to form a huge and rigid network.
has exact synonym: murein metabolic process
has exact synonym: murein metabolism
has exact synonym: peptidoglycan metabolism
replaces: GO_0009284

polysaccharide biosynthetic process
type: Class
subclass of: GO_0005976
subclass of: GO_0009059
subclass of: GO_0016051
IAO_0000115: The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.
has exact synonym: glycan biosynthesis
has exact synonym: glycan biosynthetic process
has exact synonym: polysaccharide anabolism
has exact synonym: polysaccharide biosynthesis
has exact synonym: polysaccharide formation
has exact synonym: polysaccharide synthesis

polysaccharide catabolic process
type: Class
subclass of: GO_0005976
subclass of: GO_0009057
subclass of: GO_0016052
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.
has related synonym: multicellular organismal polysaccharide catabolic process
has exact synonym: polysaccharide breakdown
has exact synonym: polysaccharide catabolism
has exact synonym: polysaccharide degradation
replaces: GO_0044244

mitochondrial proton-transporting ATP synthase, stator stalk
type: Class
subclass of: GO_0045265
subclass of: GO_0098800
subclass of: part-of-parent-276
subclass of: part-of-parent-5739
IAO_0000115: One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core.
has exact synonym: mitochondrial proton-transporting ATP synthase, peripheral stalk

mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)
type: Class
subclass of: GO_0045261
subclass of: GO_0098800
subclass of: part-of-parent-5739
subclass of: part-of-parent-5753
IAO_0000115: The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled.
has related synonym: hydrogen-transporting ATP synthase, F1 sector
has related synonym: proton-transporting ATP synthase complex, catalytic core F(1)

mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
type: Class
subclass of: GO_0045263
subclass of: GO_0098800
subclass of: part-of-parent-5739
subclass of: part-of-parent-5753
IAO_0000115: All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins.

[cytochrome c]-lysine N-methyltransferase activity
type: Class
subclass of: GO_0016279
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine. This is the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c.
has related synonym: cytochrome c (lysine) methyltransferase activity
has related synonym: cytochrome c-lysine N-methyltransferase activity
has related synonym: cytochrome c methyltransferase activity
has related synonym: cytochrome c-specific protein-lysine methyltransferase activity
has related synonym: cytochrome c-specific protein methylase III activity
has related synonym: S-adenosyl-L-methionine:cytochrome c-L-lysine 6-N-methyltransferase activity
has related synonym: S-adenosyl-L-methionine:cytochrome c-L-lysine N6-methyltransferase activity

mitotic cell cycle
type: Class
subclass of: GO_0007049
IAO_0000115: Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
has related synonym: mitosis
replaces: GO_0007067

M phase
type: Class
subclass of: GO_0022403
IAO_0000115: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase.
has exact synonym: M-phase

nuclear division
type: Class
subclass of: GO_0048285
IAO_0000115: The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.
has related synonym: karyokinesis

mitotic cytokinesis
type: Class
subclass of: GO_0061640
subclass of: GO_1903047
subclass of: part-of-parent-278
IAO_0000115: A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
has exact synonym: cytokinesis after mitosis

cellular bud site selection
type: Class
subclass of: GO_0030010
subclass of: GO_1903047
subclass of: part-of-parent-281
IAO_0000115: The specification of the site where a daughter cell will form, in organisms that reproduce by budding. An example of this process is found in Saccharomyces cerevisiae.
has related synonym: bud site selection/establishment of cell polarity

obsolete shmoo orientation
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

1-phosphatidylinositol-3-phosphate 5-kinase activity
type: Class
subclass of: GO_0016307
IAO_0000115: Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+).
has related synonym: ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase activity
has related synonym: phosphatidylinositol 3-phosphate 5-kinase activity
has exact synonym: phosphatidylinositol-3-phosphate 5-kinase activity
has related synonym: type III PIP kinase activity

alanine dehydrogenase activity
type: Class
subclass of: GO_0016638
IAO_0000115: Catalysis of the reaction: L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH + H(+).
has related synonym: AlaDH
has related synonym: alanine oxidoreductase activity
has related synonym: alpha-alanine dehydrogenase activity
has related synonym: L-alanine:NAD+ oxidoreductase (deaminating)
has related synonym: L-alanine dehydrogenase activity
has related synonym: NAD-dependent alanine dehydrogenase activity
has related synonym: NADH-dependent alanine dehydrogenase activity
has related synonym: NAD-linked alanine dehydrogenase activity

magnesium ion binding
type: Class
subclass of: GO_0046872
IAO_0000115: Binding to a magnesium (Mg) ion.
has exact synonym: magnesium binding
has exact synonym: Mg binding

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
type: Class
subclass of: nuclear-transcribed mRNA catabolic process
subclass of: GO_0061157
IAO_0000115: A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability.
has exact synonym: deadenylation-dependent mRNA decay
has exact synonym: mRNA breakdown, deadenylation-dependent decay
has exact synonym: mRNA catabolic process, deadenylation-dependent
has exact synonym: mRNA catabolic process, deadenylylation-dependent
has exact synonym: mRNA catabolism, deadenylation-dependent
has exact synonym: mRNA catabolism, deadenylylation-dependent
has exact synonym: mRNA degradation, deadenylation-dependent decay
has exact synonym: nuclear mRNA catabolic process, deadenylation-dependent decay

nuclear-transcribed mRNA poly(A) tail shortening
type: Class
subclass of: nuclear-transcribed mRNA catabolic process
subclass of: part-of-parent-288
IAO_0000115: Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length.
has related synonym: 3' to 5' mRNA deadenylation
has related synonym: mRNA deadenylation
has related synonym: nuclear mRNA poly(A) tail shortening

deadenylation-dependent decapping of nuclear-transcribed mRNA
type: Class
subclass of: nuclear-transcribed mRNA catabolic process
subclass of: GO_0110156
subclass of: part-of-parent-288
IAO_0000115: Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length.
has exact synonym: deadenylation-dependent decapping of nuclear mRNA
has exact synonym: deadenylylation-dependent decapping

nuclear-transcribed mRNA catabolic process, exonucleolytic
type: Class
subclass of: nuclear-transcribed mRNA catabolic process
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail.
has exact synonym: exonucleolytic degradation of mRNA
has exact synonym: mRNA breakdown, exonucleolytic
has exact synonym: mRNA degradation, exonucleolytic
has exact synonym: nuclear mRNA catabolic process, exonucleolytic

RNA fragment catabolic process
type: Class
subclass of: GO_0006401
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of a fragment of RNA, such as excised introns or sequences removed from ribosomal RNA during processing.
has related synonym: group I intron catabolic process
has exact synonym: RNA fragment breakdown
has exact synonym: RNA fragment catabolism
has exact synonym: RNA fragment degradation
replaces: GO_0030452

ferric-chelate reductase activity
type: Class
subclass of: GO_0016722
IAO_0000115: Catalysis of the reaction: 2 Fe3+-siderophore + electron donor -> 2 Fe3+-siderophore + electron acceptor.
has exact synonym: ferric chelate reductase activity
has exact synonym: iron chelate reductase activity

nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay
type: Class
subclass of: nuclear-transcribed mRNA catabolic process
IAO_0000115: A minor degradation pathway nuclear-transcribed mRNAs that begins with an endonucleolytic cleavage to generate unprotected ends.
has exact synonym: endonucleolytic mRNA decay
has exact synonym: mRNA breakdown, endonucleolytic cleavage-dependent decay
has exact synonym: mRNA catabolic process, endonucleolytic
has exact synonym: mRNA catabolism, endonucleolytic
has exact synonym: mRNA degradation, endonucleolytic cleavage-dependent decay
has exact synonym: nuclear mRNA catabolic process, endonucleolytic cleavage-dependent decay

adenine nucleotide transmembrane transporter activity
type: Class
subclass of: GO_0015216
subclass of: part-of-parent-51503
IAO_0000115: Enables the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of a membrane to the other.

spermine transport
type: Class
subclass of: GO_0006812
subclass of: GO_0015846
IAO_0000115: The directed movement of spermine, N,N-bis(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

spermine transmembrane transporter activity
type: Class
subclass of: GO_0008324
subclass of: GO_0015203
subclass of: part-of-parent-1903710
IAO_0000115: Enables the transfer of spermine from one side of a membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication.

endopolyphosphatase activity
type: Class
subclass of: GO_0016462
IAO_0000115: Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues.
has related synonym: metaphosphatase activity
has related synonym: polymetaphosphatase activity
has related synonym: polyphosphatase activity
has related synonym: polyphosphate depolymerase activity
has related synonym: polyphosphate polyphosphohydrolase activity

obsolete integral to membrane of membrane fraction
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Integral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; require detergents, such as Triton X-100, to be released from membranes.

obsolete peripheral to membrane of membrane fraction
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Peripheral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; can be extracted from membrane fraction with high concentrations of salt or high pH.

retrograde transport, vesicle recycling within Golgi
type: Class
subclass of: GO_0006891
IAO_0000115: The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi.
has exact synonym: retrograde (vesicle recycling within Golgi) transport

response to reactive oxygen species
type: Class
subclass of: GO_0006979
subclass of: GO_1901700
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
has exact synonym: response to active oxygen species
has exact synonym: response to AOS
has exact synonym: response to reactive oxidative species
has exact synonym: response to reactive oxygen intermediate
has exact synonym: response to ROI
has exact synonym: response to ROS

response to superoxide
type: Class
subclass of: response to oxygen radical
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion.

response to singlet oxygen
type: Class
subclass of: response to reactive oxygen species
subclass of: GO_0010035
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst.

response to oxygen radical
type: Class
subclass of: response to reactive oxygen species
subclass of: GO_0010035
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion.

extrinsic component of vacuolar membrane
type: Class
subclass of: GO_0031312
subclass of: part-of-parent-5774
IAO_0000115: The component of a vacuolar membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
has exact synonym: extrinsic to vacuolar membrane

cyclin-dependent protein kinase holoenzyme complex
type: Class
subclass of: GO_1902554
IAO_0000115: Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.
has exact synonym: CDK holoenzyme

cytoplasmic cyclin-dependent protein kinase holoenzyme complex
type: Class
subclass of: cyclin-dependent protein kinase holoenzyme complex
subclass of: part-of-parent-5737
IAO_0000115: Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm.
has related synonym: CDK holoenzyme

nicotinamide-nucleotide adenylyltransferase activity
type: Class
subclass of: GO_0070566
IAO_0000115: Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+.
has related synonym: adenosine triphosphate-nicotinamide mononucleotide transadenylase activity
has exact synonym: ATP:nicotinamide-nucleotide adenylyltransferase activity
has related synonym: ATP:NMN adenylyltransferase activity
has related synonym: diphosphopyridine nucleotide pyrophosphorylase activity
has related synonym: NAD(+) diphosphorylase activity
has related synonym: NAD(+) pyrophosphorylase activity
has related synonym: NAD+ diphosphorylase activity
has related synonym: NAD+ pyrophosphorylase activity
has related synonym: nicotinamide adenine dinucleotide pyrophosphorylase activity
has related synonym: nicotinamide mononucleotide adenylyltransferase activity
has related synonym: NMN adenylyltransferase activity
has related synonym: NMNAT activity

xanthine phosphoribosyltransferase activity
type: Class
subclass of: GO_0106130
IAO_0000115: Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + xanthine = (9-D-ribosylxanthine)-5'-phosphate + diphosphate.
has related synonym: 5-phospho-alpha-D-ribose-1-diphosphate:xanthine phospho-D-ribosyltransferase activity
has related synonym: Xan phosphoribosyltransferase activity
has exact synonym: xanthine-guanine phosphoribosyltransferase activity
has related synonym: xanthosine 5'-phosphate pyrophosphorylase activity
has related synonym: xanthylate pyrophosphorylase activity
has related synonym: xanthylic pyrophosphorylase activity
has related synonym: XMP:diphosphate 5-phospho-alpha-D-ribosyltransferase activity
has related synonym: XMP pyrophosphorylase activity
replaces: GO_0009043

plastid large ribosomal subunit
type: Class
subclass of: organellar large ribosomal subunit
subclass of: part-of-parent-9547
IAO_0000115: The larger of the two subunits of a plastid ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).

plastid small ribosomal subunit
type: Class
subclass of: organellar small ribosomal subunit
subclass of: part-of-parent-9547
IAO_0000115: The smaller of the two subunits of a plastid ribosome.

organellar ribosome
type: Class
subclass of: GO_0005840
subclass of: part-of-parent-43226
IAO_0000115: A ribosome contained within a subcellular membrane-bounded organelle.

organellar small ribosomal subunit
type: Class
subclass of: GO_0015935
subclass of: part-of-parent-313
IAO_0000115: The smaller of the two subunits of an organellar ribosome.

organellar large ribosomal subunit
type: Class
subclass of: GO_0015934
subclass of: part-of-parent-313
IAO_0000115: The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).

sulfite transport
type: Class
subclass of: GO_0015698
subclass of: GO_0072348
IAO_0000115: The directed movement of sulfite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has exact synonym: sulphite transport

sulfite transmembrane transporter activity
type: Class
subclass of: GO_0015103
subclass of: GO_1901682
subclass of: part-of-parent-316
IAO_0000115: Enables the transfer of sulfite ions from one side of a membrane to the other.
has exact synonym: sulphite transporter activity

re-entry into mitotic cell cycle
type: Class
subclass of: GO_0022402
IAO_0000115: The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state.

re-entry into mitotic cell cycle after pheromone arrest
type: Class
subclass of: re-entry into mitotic cell cycle
subclass of: adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion
IAO_0000115: The resumption of the mitotic cell division cycle by pheromone-arrested cells that have not mated. An example of this process is found in Saccharomyces cerevisiae.

storage vacuole
type: Class
subclass of: GO_0005773
IAO_0000115: A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules.

lytic vacuole
type: Class
subclass of: GO_0005773
IAO_0000115: A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases.

fungal-type vacuole
type: Class
subclass of: storage vacuole
subclass of: lytic vacuole
IAO_0000115: A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
has exact synonym: vacuole, cell cycle-correlated morphology

plant-type vacuole
type: Class
subclass of: GO_0005773
IAO_0000115: A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana.
has exact synonym: vacuole, cell cycle-independent morphology

protein storage vacuole
type: Class
subclass of: storage vacuole
subclass of: plant-type vacuole
IAO_0000115: A storage vacuole that contains a lytic vacuole; identified in plants.

lytic vacuole within protein storage vacuole
type: Class
subclass of: lytic vacuole
subclass of: part-of-parent-326
IAO_0000115: A membrane-bounded compartment containing crystals of phytic acid and proteins characteristic of a lytic vacuole, found within a storage vacuole.

fungal-type vacuole lumen
type: Class
subclass of: GO_0005775
subclass of: part-of-parent-324
IAO_0000115: The volume enclosed within the vacuolar membrane of a vacuole, the shape of which correlates with cell cycle phase. An example of this structure is found in Saccharomyces cerevisiae.
has exact synonym: lumen of vacuole with cell cycle-correlated morphology

fungal-type vacuole membrane
type: Class
subclass of: GO_0098852
subclass of: part-of-parent-324
IAO_0000115: The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
has related synonym: fungal-type vacuolar membrane
has exact synonym: membrane of vacuole with cell cycle-correlated morphology

plant-type vacuole lumen
type: Class
subclass of: GO_0005775
subclass of: part-of-parent-325
IAO_0000115: The volume enclosed within the vacuolar membrane of a vacuole that retains the same shape regardless of cell cycle phase. An example of this is found in Arabidopsis thaliana.
has exact synonym: lumen of vacuole with cell cycle-independent morphology

contractile vacuole
type: Class
subclass of: GO_0005773
subclass of: GO_0031410
subclass of: part-of-parent-62159
IAO_0000115: A specialized vacuole of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores. One of its functions is osmoregulatory.
has related synonym: central bladder
has related synonym: central vacuole

template for synthesis of G-rich strand of telomere DNA activity
type: Class
subclass of: DNA template activity
subclass of: part-of-parent-3720
IAO_0000115: Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA.
has exact synonym: telomerase, template
has exact synonym: telomerase RNA

telomerase catalytic core complex
type: Class
subclass of: GO_0005697
subclass of: GO_0061695
IAO_0000115: The minimal catalytic core of telomerase is a ribonucleoprotein complex composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition.
has related synonym: TERT-TERC complex

3-hydroxyanthranilate 3,4-dioxygenase activity
type: Class
subclass of: GO_0016702
IAO_0000115: Catalysis of the reaction: 3-hydroxyanthranilate + O(2) = cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+).
has related synonym: 3HAO
has related synonym: 3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing)
has related synonym: 3-hydroxyanthranilate oxygenase activity
has related synonym: 3-hydroxyanthranilic acid dioxygenase activity
has related synonym: 3-hydroxyanthranilic acid oxygenase activity
has related synonym: 3-hydroxyanthranilic oxygenase activity

negative regulation of transposition, DNA-mediated
type: Class
subclass of: regulation of transposition, DNA-mediated
subclass of: GO_0010529
subclass of: GO_0045910
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of DNA transposition.
has exact synonym: downregulation of DNA transposition
has exact synonym: down regulation of DNA transposition
has exact synonym: down-regulation of DNA transposition
has related synonym: inhibition of DNA transposition
has exact synonym: negative regulation of DNA transposition

positive regulation of transposition, DNA-mediated
type: Class
subclass of: regulation of transposition, DNA-mediated
subclass of: GO_0010530
subclass of: GO_0045911
IAO_0000115: Any process that activates or increases the frequency, rate or extent of DNA transposition.
has related synonym: activation of DNA transposition
has exact synonym: positive regulation of DNA transposition
has related synonym: stimulation of DNA transposition
has exact synonym: upregulation of DNA transposition
has exact synonym: up regulation of DNA transposition
has exact synonym: up-regulation of DNA transposition

regulation of transposition, DNA-mediated
type: Class
subclass of: regulation of DNA recombination
subclass of: GO_0010528
IAO_0000115: Any process that modulates the frequency, rate or extent of DNA transposition, the process of transposing (moving to a different location) a segment of a chromosome or a piece of a DNA molecule.
has exact synonym: regulation of DNA transposition

protein deneddylation
type: Class
subclass of: GO_0070646
IAO_0000115: The removal of a ubiquitin-like protein of the NEDD8 type from a protein.
has related synonym: cullin deneddylation
replaces: GO_0010388

RNA cap binding
type: Class
subclass of: RNA binding
IAO_0000115: Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule.
has related synonym: binding to mRNA cap
has related synonym: mRNA cap binding
has related synonym: snRNA cap binding

RNA 7-methylguanosine cap binding
type: Class
subclass of: RNA cap binding
IAO_0000115: Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II.
has exact synonym: RNA m7G cap binding

RNA trimethylguanosine cap binding
type: Class
subclass of: RNA cap binding
IAO_0000115: Binding to the trimethylguanosine (m(3)(2,2,7)-GTP) group located at the 5' end of some RNA molecules. Such trimethylated cap structures, generally produced by posttranscriptional modification of a 7-methylguanosine cap, are often found on snRNAs and snoRNAs transcribed by RNA polymerase II, but have also be found on snRNAs transcribed by RNA polymerase III. They have also been found on a subset of the mRNA population in some species, e.g. C. elegans.
has exact synonym: RNA m2,2,7G cap binding

RNA cap 4 binding
type: Class
subclass of: RNA cap binding
IAO_0000115: Binding to a hypermethylated cap structure consisting of 7-methylguanosine (m(7)G) followed by four methylated nucleotides (cap 4): 7-methylguanosine-ppp-N6, N6, 2'-O-trimethyladenosine-p-2'-O-methyladenosine-p-2'-O-methylcytosine-p-N3, 2'-O-dimethyluridine Such caps are known to be found at the 5' ends of SL RNAs of trypanosomatid protozoa.

plastid-encoded plastid RNA polymerase complex A
type: Class
subclass of: plastid-encoded plastid RNA polymerase complex
IAO_0000115: A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-A is generated from the PEP-B form during chloroplast maturation to generate a complex composed of at least thirteen polypeptides that is not sensitive to the antibiotic rifampicin, like its precursor form the PEP-B complex.
has exact synonym: PEP-A

plastid-encoded plastid RNA polymerase complex B
type: Class
subclass of: plastid-encoded plastid RNA polymerase complex
IAO_0000115: A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-B is distinguished from PEP-A by its sensitivity to the antibiotic rifampicin. PEP-B is found in both etioplasts and chloroplasts, but is the predominate form in etioplasts. It forms the core of the PEP-A form; the conversion from PEP-B to PEP-A occurs during chloroplast maturation.
has exact synonym: PEP-B

cytosolic DNA-directed RNA polymerase complex
type: Class
subclass of: DNA-directed RNA polymerase complex
subclass of: part-of-parent-5829
IAO_0000115: The eubacterial DNA-directed RNA polymerase is a multisubunit complex with a core composed of the essential subunits beta-prime, beta, and two copies of alpha and a fifth nonessential subunit called omega. An additional subunit, a sigma factor, is required for promoter recognition and specificity.

transcription export complex
type: Class
subclass of: GO_0140513
IAO_0000115: The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans.
has exact synonym: TREX complex

THO complex
type: Class
subclass of: GO_0140513
IAO_0000115: The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits.

mRNA branch site recognition
type: Class
subclass of: GO_0022618
subclass of: part-of-parent-245
IAO_0000115: Recognition of the pre-mRNA branch site sequence by components of the assembling spliceosome.
has exact synonym: nuclear mRNA branch site recognition
has related synonym: spliceosomal A complex biosynthesis
has related synonym: spliceosomal A complex formation
has related synonym: spliceosomal B complex biosynthesis
has related synonym: spliceosomal B complex formation
has related synonym: U12-type nuclear mRNA branch site recognition
has related synonym: U2-type nuclear mRNA branch site recognition
replaces: GO_0000370
replaces: GO_0000371

generation of catalytic spliceosome for first transesterification step
type: Class
subclass of: GO_0022618
subclass of: part-of-parent-393
IAO_0000115: Formation of a catalytic spliceosome complex ready to perform the first splicing reaction. This occurs by an ATP-dependent conformational change of the pre-catalytic spliceosome.
has related synonym: catalytic spliceosome assembly for first transesterification step
has exact synonym: formation of catalytic spliceosome for first transesterification step
has related synonym: spliceosomal A2-2 complex biosynthesis
has related synonym: spliceosomal A2-2 complex formation
has related synonym: spliceosomal C1 complex biosynthesis
has related synonym: spliceosomal C1 complex formation
has related synonym: U12-type catalytic spliceosome formation for first transesterification step
has related synonym: U2-type catalytic spliceosome formation for first transesterification step
replaces: GO_0000356
replaces: GO_0000357

generation of catalytic spliceosome for second transesterification step
type: Class
subclass of: GO_0022618
subclass of: part-of-parent-393
IAO_0000115: Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing.
has related synonym: catalytic spliceosome assembly for second transesterification step
has exact synonym: formation of catalytic spliceosome for second transesterification step
has related synonym: formation of catalytic U12-type spliceosome for second transesterification step
has related synonym: formation of catalytic U2-type spliceosome for second transesterification step
has related synonym: formation of spliceosomal A2-2 complex
has related synonym: formation of spliceosomal C1 complex
has related synonym: lariat formation, 5'-splice site cleavage
has related synonym: spliceosomal A2-3 complex biosynthesis
has related synonym: spliceosomal A2-3 complex formation
has related synonym: spliceosomal C2 complex biosynthesis
has related synonym: spliceosomal C2 complex formation
replaces: GO_0000358
replaces: GO_0000359

trans assembly of SL-containing precatalytic spliceosome
type: Class
subclass of: GO_0022618
subclass of: part-of-parent-245
subclass of: part-of-parent-45291
IAO_0000115: Assembly of a spliceosomal complex containing the SL RNA and the pre-mRNA to be joined, as well as all the spliceosomal snRNPs involved in trans leader splicing. Formation of the trans leader spliceosome brings together the quadruple SL/U4/U5/U6 snRNP and the complex of the U2 snRNP with the splice site of the pre-mRNA.
has exact synonym: trans assembly of spliced leader-containing precatalytic spliceosome

formation of quadruple SL/U4/U5/U6 snRNP
type: Class
subclass of: GO_0022618
subclass of: part-of-parent-45291
IAO_0000115: Formation of a quadruple snRNP complex composed of the spliced leader (SL) RNA along with the U4/U6-U5 tri-snRNP complex. Interactions that may facilitate this include a duplex between the SL and U6 RNAs and interactions between the U5 RNA and the exon sequence at the 5' splice site within the SL RNA.

cis assembly of pre-catalytic spliceosome
type: Class
subclass of: GO_0022618
subclass of: part-of-parent-245
subclass of: part-of-parent-45292
IAO_0000115: Assembly of a spliceosomal complex containing the intact pre-mRNA and all of the spliceosomal snRNPs. This occurs when the tri-snRNP associates with the pre-mRNA and associated snRNPs in an ATP-dependent manner.
has related synonym: cis assembly of U12-type pre-catalytic spliceosome
has related synonym: cis assembly of U2-type pre-catalytic spliceosome
has related synonym: formation of spliceosomal A2-1 complex
has related synonym: formation of spliceosomal B1 complex
has related synonym: spliceosomal A2-1 complex biosynthesis
has related synonym: spliceosomal A2-1 complex formation
has related synonym: spliceosomal B1 complex biosynthesis
has related synonym: spliceosomal B1 complex formation
replaces: GO_0000360
replaces: GO_0000361

obsolete first U2-type spliceosomal transesterification activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the first transesterification reaction of U2-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6 and/or U2 snRNA, and/or associated proteins.

obsolete first U12-type spliceosomal transesterification activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the first transesterification reaction of U12-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6atac snRNA and/or U2atac snRNA, and/or associated proteins.

obsolete second U2-type spliceosomal transesterification activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the second transesterification reaction of U2-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins.

mRNA trans splicing, via spliceosome
type: Class
subclass of: mRNA splicing, via spliceosome
IAO_0000115: The joining together of exons from two different primary transcripts of messenger RNA (mRNA) via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
has exact synonym: nuclear mRNA trans splicing, via spliceosome
has related synonym: nuclear mRNA trans splicing, via U2-type spliceosome

intergenic mRNA trans splicing
type: Class
subclass of: mRNA trans splicing, via spliceosome
subclass of: alternative mRNA splicing, via spliceosome
IAO_0000115: The joining together of two independently transcribed RNAs from two different genes, each of which also produces mRNA(s) via cis-splicing.
has exact synonym: intergenic nuclear mRNA trans splicing

obsolete second U12-type spliceosomal transesterification activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the second transesterification reaction of U12-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins.

Group I intron splicing
type: Class
subclass of: RNA splicing, via transesterification reactions with guanosine as nucleophile
IAO_0000115: The splicing of Group I introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group I introns and involved in determining the locations of the splice sites (there do not appear to be consensus splice site sequences) as well as having a role in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions, generally with exogenous guanosine as the initiating nucleophile. The intron is excised as a linear piece (though it may subsequently circularize).
has related synonym: mRNA splicing

Group II intron splicing
type: Class
subclass of: RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
IAO_0000115: The splicing of Group II introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group II introns and containing splice site consensus sequences, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions (mechanistically similar to those for splicing of nuclear mRNAs) initiated by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat.
has related synonym: mRNA splicing

Group III intron splicing
type: Class
subclass of: RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
IAO_0000115: The splicing of Group III introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group III introns, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions begun by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat. Though very similar in structure and mechanism to Group II introns, Group III introns are smaller and more streamlined and the splice site consensus sequences are not as well conserved.
has related synonym: mRNA splicing

RNA splicing, via transesterification reactions
type: Class
subclass of: GO_0008380
IAO_0000115: Splicing of RNA via a series of two transesterification reactions.
has related synonym: pre-mRNA splicing factor activity
has related synonym: RNA splicing factor activity, transesterification mechanism
has related synonym: spliceosomal catalysis
replaces: GO_0000385
replaces: GO_0031202

RNA splicing, via transesterification reactions with guanosine as nucleophile
type: Class
subclass of: RNA splicing, via transesterification reactions
IAO_0000115: Splicing of RNA via a series of two transesterification reactions with exogenous guanosine as the initiating nucleophile.

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
type: Class
subclass of: RNA splicing, via transesterification reactions
IAO_0000115: Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure.
has related synonym: lariat RNA biosynthesis
has related synonym: lariat RNA formation

RNA exon ligation
type: Class
subclass of: GO_0016070
subclass of: part-of-parent-394
IAO_0000115: The RNA metabolic process that joins two exons, each of which has free ends that were generated by endonucleolytic cleavages, by a ligation reaction.

tRNA-type intron splice site recognition and cleavage
type: Class
subclass of: GO_0034470
subclass of: part-of-parent-6388
IAO_0000115: RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs.

alternative mRNA splicing, via spliceosome
type: Class
subclass of: mRNA splicing, via spliceosome
IAO_0000115: The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.
has exact synonym: alternative nuclear mRNA splicing, via spliceosome
has related synonym: splice site selection

regulation of alternative mRNA splicing, via spliceosome
type: Class
subclass of: GO_0048024
IAO_0000115: Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
has exact synonym: regulation of alternative nuclear mRNA splicing, via spliceosome
has related synonym: splice site selection

first spliceosomal transesterification activity
type: Class
subclass of: GO_0140098
subclass of: part-of-parent-375
IAO_0000115: Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon.
has related synonym: lariat formation, 5'-splice site cleavage

second spliceosomal transesterification activity
type: Class
subclass of: GO_0140098
subclass of: part-of-parent-375
IAO_0000115: Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure.
has related synonym: 3'-splice site cleavage, exon ligation
has related synonym: lariat formation, 5'-splice site cleavage

spliceosomal snRNP assembly
type: Class
subclass of: GO_0022618
subclass of: part-of-parent-398
IAO_0000115: The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome.
has related synonym: spliceosomal snRNP biogenesis

spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
type: Class
subclass of: GO_0022618
subclass of: part-of-parent-393
IAO_0000115: Rearrangement of the pre-catalytic spliceosome containing U4 (or U4atac) and U1 (or U11) snRNPs to unpair U4 (or U4atac) from U6 (or U6atac) and release it from the spliceosomal complex along with U1 (or U11).
has related synonym: 3'-splice site cleavage, exon ligation
has related synonym: spliceosomal A1 complex biosynthesis
has related synonym: spliceosomal A1 complex formation
has related synonym: spliceosomal B2 complex biosynthesis
has related synonym: spliceosomal B2 complex formation
has related synonym: U12-type spliceosome conformational change to release U4atac and U11
has related synonym: U2-type spliceosome conformational change to release U4 and U1
replaces: GO_0000396
replaces: GO_0000397

mRNA 3'-splice site recognition
type: Class
subclass of: GO_0006376
IAO_0000115: Recognition of the intron 3'-splice site by components of the assembling U2- or U12-type spliceosome.
has exact synonym: nuclear mRNA 3'-splice site recognition
has related synonym: U12-type nuclear mRNA 3'-splice site recognition
has related synonym: U2-type nuclear mRNA 3'-splice site recognition
replaces: GO_0000382
replaces: GO_0000383

spliceosomal complex disassembly
type: Class
subclass of: GO_0032988
subclass of: part-of-parent-398
IAO_0000115: Disassembly of a spliceosomal complex with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure.
has exact synonym: spliceosome complex disassembly
has related synonym: spliceosome disassembly
has related synonym: U12-type spliceosome disassembly
has related synonym: U2-type spliceosome disassembly
replaces: GO_0000391
replaces: GO_0000392

spliceosomal conformational changes to generate catalytic conformation
type: Class
subclass of: GO_0022618
subclass of: part-of-parent-398
IAO_0000115: Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation.
has related synonym: 3'-splice site cleavage, exon ligation

RNA splicing, via endonucleolytic cleavage and ligation
type: Class
subclass of: GO_0008380
IAO_0000115: Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.
has related synonym: mRNA splicing

mRNA 5'-splice site recognition
type: Class
subclass of: GO_0006376
subclass of: part-of-parent-45292
IAO_0000115: Recognition of the intron 5'-splice site by components of the assembling spliceosome.
has exact synonym: nuclear mRNA 5' splice site recognition
has exact synonym: nuclear mRNA 5'-splice site recognition
has related synonym: spliceosomal CC complex biosynthesis
has related synonym: spliceosomal CC complex formation
has related synonym: spliceosomal commitment complex biosynthesis
has related synonym: spliceosomal commitment complex formation
has related synonym: spliceosomal E complex biosynthesis
has related synonym: spliceosomal E complex formation
has related synonym: U12-type nuclear mRNA 5' splice site recognition
has related synonym: U12-type nuclear mRNA 5'-splice site recognition
has related synonym: U2-type nuclear mRNA 5' splice site recognition
has related synonym: U2-type nuclear mRNA 5'-splice site recognition
replaces: GO_0000368
replaces: GO_0000369

mRNA splicing, via spliceosome
type: Class
subclass of: RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
subclass of: GO_0006397
IAO_0000115: The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
has related synonym: mRNA splicing
has exact synonym: nuclear mRNA splicing, via spliceosome
has related synonym: nuclear mRNA splicing via U12-type spliceosome
has related synonym: nuclear mRNA splicing via U2-type spliceosome
has related synonym: pre-mRNA splicing
has related synonym: splicing AT-AC intron
has related synonym: splicing GT-AG intron
replaces: GO_0006374
replaces: GO_0006375

cellular bud neck septin structure
type: Class
subclass of: GO_0110165
subclass of: part-of-parent-5935
subclass of: part-of-parent-32153
IAO_0000115: Any of a series of septin structures that are localized in the bud neck of a budding fungal cell during the cell cycle.

four-way junction DNA binding
type: Class
subclass of: DNA secondary structure binding
IAO_0000115: Binding to a DNA segment containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices.
has related synonym: forked DNA binding
has exact synonym: Holliday junction binding

open form four-way junction DNA binding
type: Class
subclass of: four-way junction DNA binding
IAO_0000115: Binding to a DNA segment containing the open form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The open form of a four-way junction can be diagrammed without any of the strands crossing over.
has exact synonym: open form Holliday junction binding

crossed form four-way junction DNA binding
type: Class
subclass of: four-way junction DNA binding
IAO_0000115: Binding to a DNA segment containing the crossed form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The crossed form of a four-way junction cannot be diagrammed without any of the strands crossing over, and instead contains a single crossover between two of the strands.
has exact synonym: crossed form Holliday junction binding

Y-form DNA binding
type: Class
subclass of: DNA secondary structure binding
IAO_0000115: Binding to a DNA segment shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end.
has related synonym: forked DNA binding
has exact synonym: splayed Y-form DNA binding

heteroduplex DNA loop binding
type: Class
subclass of: DNA secondary structure binding
subclass of: GO_0032135
IAO_0000115: Binding to a DNA segment containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration.
has related synonym: loop DNA binding

bubble DNA binding
type: Class
subclass of: DNA secondary structure binding
IAO_0000115: Binding to DNA segment that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA.

double-strand/single-strand DNA junction binding
type: Class
subclass of: DNA secondary structure binding
IAO_0000115: Binding to a DNA segment that contains double-stranded DNA flanked by a region of single-stranded DNA.

phagophore assembly site
type: Class
subclass of: GO_0110165
subclass of: part-of-parent-5737
IAO_0000115: Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction.
has exact synonym: PAS
has related synonym: perivacuolar space
has related synonym: pre-autophagosomal structure

EKC/KEOPS complex
type: Class
subclass of: GO_0032991
IAO_0000115: A protein complex involved in t6A tRNA modification. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p.
has exact synonym: endopeptidase-like kinase chromatin-associated protein complex
has exact synonym: KEOPS/EKC complex
has exact synonym: kinase, putative endopeptidase and other proteins of small size protein complex
has related synonym: TCTC
has related synonym: threonyl-carbamoly transferase complex

regulation of transcription by galactose
type: Class
subclass of: GO_0006355
IAO_0000115: Any process involving galactose that modulates the frequency, rate or extent or transcription.

carbon catabolite repression of transcription by galactose
type: Class
subclass of: regulation of transcription by galactose
subclass of: GO_0045013
IAO_0000115: A transcription regulation process in which the presence of galactose that leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances.
has exact synonym: downregulation of transcription by galactose
has exact synonym: down regulation of transcription by galactose
has exact synonym: down-regulation of transcription by galactose
has related synonym: inhibition of transcription by galactose

positive regulation of transcription by galactose
type: Class
subclass of: regulation of transcription by galactose
subclass of: GO_0045991
IAO_0000115: Any process involving galactose that activates or increases the rate of transcription.
has related synonym: activation of transcription by galactose
has related synonym: stimulation of transcription by galactose
has exact synonym: upregulation of transcription by galactose
has exact synonym: up regulation of transcription by galactose
has exact synonym: up-regulation of transcription by galactose

histone peptidyl-prolyl isomerization
type: Class
subclass of: protein peptidyl-prolyl isomerization
subclass of: GO_0016570
IAO_0000115: The modification of a histone by cis-trans isomerization of a proline residue.
has exact synonym: histone proline isomerization

protein peptidyl-prolyl isomerization
type: Class
subclass of: GO_0018208
IAO_0000115: The modification of a protein by cis-trans isomerization of a proline residue.
has exact synonym: protein proline isomerization

regulation of histone H3-K36 methylation
type: Class
subclass of: GO_0031060
IAO_0000115: Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3.

negative regulation of histone H3-K36 methylation
type: Class
subclass of: regulation of histone H3-K36 methylation
subclass of: GO_0031061
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3.
has exact synonym: downregulation of histone H3-K36 methylation
has exact synonym: down regulation of histone H3-K36 methylation
has exact synonym: down-regulation of histone H3-K36 methylation
has related synonym: inhibition of histone H3-K36 methylation

positive regulation of histone H3-K36 methylation
type: Class
subclass of: regulation of histone H3-K36 methylation
subclass of: GO_0031062
IAO_0000115: Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3.
has related synonym: activation of histone H3-K36 methylation
has related synonym: stimulation of histone H3-K36 methylation
has exact synonym: upregulation of histone H3-K36 methylation
has exact synonym: up regulation of histone H3-K36 methylation
has exact synonym: up-regulation of histone H3-K36 methylation

HIR complex
type: Class
subclass of: GO_0032991
IAO_0000115: A protein complex proposed to be involved in replication-independent nucleosome assembly, by promoting histone deposition onto DNA. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p.
has exact synonym: HIRA complex

RNA polymerase IV complex
type: Class
subclass of: GO_0055029
subclass of: part-of-parent-5634
IAO_0000115: RNA polymerase IV is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol IV is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. The largest and second-largest subunits of Pol IV are the catalytic subunits and share similarity with the corresponding subunits of other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase V, while the largest subunit is found only in RNAP IV complex.
has exact synonym: DNA-directed RNA polymerase IVa complex
has exact synonym: DNA-directed RNA polymerase IV complex
replaces: GO_0000420

RNA polymerase V complex
type: Class
subclass of: GO_0055029
subclass of: part-of-parent-5634
IAO_0000115: RNA polymerase V is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol V is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVa, while the largest subunit is found only in the IVa complex and contains an extended C-terminal domain (CTD) that includes multiple repeats of a 16 amino-acid consensus sequence as well as other sequences. The remainder of the complex is composed of smaller subunits.
has exact synonym: DNA-directed RNA polymerase IVb complex
has exact synonym: DNA-directed RNA polymerase V complex
replaces: GO_0080137

autophagosome membrane
type: Class
subclass of: GO_0005774
subclass of: part-of-parent-5776
IAO_0000115: The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered.
has exact synonym: autophagic vacuole membrane

autophagy of mitochondrion
type: Class
subclass of: GO_0006914
subclass of: GO_0061726
IAO_0000115: The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions.
has exact synonym: mitochondrion autophagy
has related synonym: mitophagy

mitophagy
type: Class
subclass of: autophagy of mitochondrion
subclass of: GO_0061912
IAO_0000115: The selective autophagy process in which a mitochondrion is degraded by macroautophagy.
has exact synonym: macromitophagy

micromitophagy
type: Class
subclass of: autophagy of mitochondrion
subclass of: GO_0016237
IAO_0000115: Degradation of a mitochondrion by lysosomal microautophagy.

pexophagy
type: Class
subclass of: GO_0030242
subclass of: GO_0061912
IAO_0000115: The selective autophagy process in which a peroxisome is degraded by macroautophagy.
has exact synonym: macropexophagy

micropexophagy
type: Class
subclass of: GO_0016237
subclass of: GO_0030242
IAO_0000115: Degradation of a peroxisome by lysosomal microautophagy.

plastid-encoded plastid RNA polymerase complex
type: Class
subclass of: DNA-directed RNA polymerase complex
subclass of: part-of-parent-9536
IAO_0000115: An RNA polymerase complex containing polypeptides encoded by the plastid genome. Plastid-encoded DNA-directed RNA polymerases resemble eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. Some forms contain multiple additional subunits. An additional sigma factor subunit is required for promoter recognition.

DNA-directed RNA polymerase complex
type: Class
subclass of: GO_0030880
IAO_0000115: A protein complex that possesses DNA-directed RNA polymerase activity.

carbon catabolite regulation of transcription from RNA polymerase II promoter
type: Class
subclass of: GO_0006357
subclass of: GO_0045990
IAO_0000115: A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources.
has exact synonym: regulation of transcription from RNA polymerase II promoter by carbon catabolites

regulation of transcription from RNA polymerase II promoter by glucose
type: Class
subclass of: carbon catabolite regulation of transcription from RNA polymerase II promoter
subclass of: GO_0046015
IAO_0000115: Any process involving glucose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.

regulation of transcription from RNA polymerase II promoter by galactose
type: Class
subclass of: regulation of transcription by galactose
subclass of: carbon catabolite regulation of transcription from RNA polymerase II promoter
IAO_0000115: Any process involving galactose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.

positive regulation of transcription from RNA polymerase II promoter by glucose
type: Class
subclass of: regulation of transcription from RNA polymerase II promoter by glucose
subclass of: carbon catabolite activation of transcription from RNA polymerase II promoter
subclass of: GO_0046016
IAO_0000115: Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter.
has related synonym: activation of transcription from RNA polymerase II promoter by glucose
has related synonym: stimulation of transcription from RNA polymerase II promoter by glucose
has exact synonym: upregulation of transcription from RNA polymerase II promoter by glucose
has exact synonym: up regulation of transcription from RNA polymerase II promoter by glucose
has exact synonym: up-regulation of transcription from RNA polymerase II promoter by glucose

carbon catabolite repression of transcription from RNA polymerase II promoter by glucose
type: Class
subclass of: GO_0045014
subclass of: GO_0061987
IAO_0000115: A transcription regulation process in which the presence of glucose leads to a decrease in the frequency, rate, or extent of transcription of specific RNA polymerase II-transcribed genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances.
has exact synonym: downregulation of transcription from RNA polymerase II promoter by glucose
has exact synonym: down regulation of transcription from RNA polymerase II promoter by glucose
has exact synonym: down-regulation of transcription from RNA polymerase II promoter by glucose
has related synonym: inhibition of transcription from RNA polymerase II promoter by glucose

carbon catabolite repression of transcription from RNA polymerase II promoter by galactose
type: Class
subclass of: carbon catabolite repression of transcription by galactose
subclass of: regulation of transcription from RNA polymerase II promoter by galactose
subclass of: carbon catabolite repression of transcription from RNA polymerase II promoter
IAO_0000115: Any process involving galactose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter.
has exact synonym: downregulation of transcription from RNA polymerase II promoter by galactose
has exact synonym: down regulation of transcription from RNA polymerase II promoter by galactose
has exact synonym: down-regulation of transcription from RNA polymerase II promoter by galactose
has related synonym: inhibition of transcription from RNA polymerase II promoter by galactose

positive regulation of transcription from RNA polymerase II promoter by galactose
type: Class
subclass of: positive regulation of transcription by galactose
subclass of: regulation of transcription from RNA polymerase II promoter by galactose
subclass of: carbon catabolite activation of transcription from RNA polymerase II promoter
IAO_0000115: Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter.
has related synonym: activation of transcription from RNA polymerase II promoter by galactose
has related synonym: stimulation of transcription from RNA polymerase II promoter by galactose
has exact synonym: upregulation of transcription from RNA polymerase II promoter by galactose
has exact synonym: up regulation of transcription from RNA polymerase II promoter by galactose
has exact synonym: up-regulation of transcription from RNA polymerase II promoter by galactose

carbon catabolite activation of transcription from RNA polymerase II promoter
type: Class
subclass of: carbon catabolite regulation of transcription from RNA polymerase II promoter
subclass of: GO_0045944
subclass of: GO_0045991
IAO_0000115: Any process involving carbon catabolites that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
has exact synonym: positive regulation of transcription from RNA polymerase II promoter by carbon catabolites

carbon catabolite repression of transcription from RNA polymerase II promoter
type: Class
subclass of: negative regulation of transcription by RNA polymerase II
subclass of: carbon catabolite regulation of transcription from RNA polymerase II promoter
subclass of: GO_0045013
IAO_0000115: A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources.
has exact synonym: negative regulation of transcription from RNA polymerase II promoter by carbon catabolites

core TFIIH complex portion of holo TFIIH complex
type: Class
subclass of: transcription factor TFIIH core complex
subclass of: part-of-parent-5675
IAO_0000115: The core TFIIH complex when it is part of the general transcription factor TFIIH.
has exact synonym: SSL2-core TFIIH complex portion of holo TFIIH complex
replaces: GO_0000443

transcription factor TFIIH core complex
type: Class
subclass of: GO_0090575
IAO_0000115: The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD.
has exact synonym: core TFIIH complex
has exact synonym: SSL2-core TFIIH complex
replaces: GO_0000441

core TFIIH complex portion of NEF3 complex
type: Class
subclass of: transcription factor TFIIH core complex
subclass of: part-of-parent-112
IAO_0000115: The core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3).
has exact synonym: SSL2-core TFIIH complex portion of NEF3 complex
replaces: GO_0000442

MIS12/MIND type complex
type: Class
subclass of: GO_0032991
subclass of: part-of-parent-776
IAO_0000115: A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1.
has related synonym: Mis12 complex

THO complex part of transcription export complex
type: Class
subclass of: THO complex
subclass of: part-of-parent-346
IAO_0000115: The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits.
has exact synonym: THO complex part of TREX complex

nucleoplasmic THO complex
type: Class
subclass of: THO complex
subclass of: GO_0008023
IAO_0000115: The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp2, and Mft1, while the human complex is composed of 7 subunits.

endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
type: Class
subclass of: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
subclass of: part-of-parent-462
subclass of: part-of-parent-466
IAO_0000115: Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
has related synonym: endonucleolytic cleavage at A2

cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
type: Class
subclass of: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
subclass of: part-of-parent-463
subclass of: part-of-parent-466
IAO_0000115: Endonucleolytic cleavage within ITS2 between the 5.8S rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
has related synonym: cleavage at C2
has exact synonym: cleavage in ITS2 of tricistronic rRNA transcript to separate 5.8S and LSU rRNAs (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
replaces: GO_0000490

endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
type: Class
subclass of: endonucleolytic cleavage involved in rRNA processing
IAO_0000115: Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. For example, primary ribosomal RNA transcripts containing three genes, in this order, are produced in E. coli and other prokaryotic species. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.

cleavage of bicistronic rRNA transcript (SSU-rRNA, LSU-rRNA)
type: Class
subclass of: endonucleolytic cleavage involved in rRNA processing
IAO_0000115: Endonucleolytic cleavage of pre-rRNAs originally produced as a bicistronic rRNA transcript that contains the SSU-rRNA and the LSU-rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with two genes in this order are produced in Archaeal species.

rRNA 2'-O-methylation
type: Class
subclass of: GO_0031167
IAO_0000115: The addition of a methyl group to the 2'-oxygen atom of a nucleotide residue in an rRNA molecule during ribosome biogenesis.

snoRNA guided rRNA 2'-O-methylation
type: Class
subclass of: rRNA 2'-O-methylation
IAO_0000115: The posttranscriptional addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of methylation.
has related synonym: snoRNA guided rRNA 2'-O-ribose methylation

enzyme-directed rRNA 2'-O-methylation
type: Class
subclass of: rRNA 2'-O-methylation
IAO_0000115: The addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis where the methylase specifies the site that becomes methylated without using a guide RNA.

snoRNA guided rRNA pseudouridine synthesis
type: Class
subclass of: GO_0031118
IAO_0000115: The intramolecular conversion of uridine to pseudouridine in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of pseudouridylation.

enzyme-directed rRNA pseudouridine synthesis
type: Class
subclass of: GO_0031118
IAO_0000115: The intramolecular conversion of uridine to pseudouridine during ribosome biogenesis where the enzyme specifies the site that becomes pseudouridylated without using a guide RNA.

obsolete dimethylation involved in SSU-rRNA maturation
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Dimethylation of the N6 amino groups of two consecutive adenosine residues near the 3'-end of the SSU rRNA. This process has been conserved from bacteria to eukaryotes.

endonucleolytic cleavage between SSU-rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
type: Class
subclass of: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
subclass of: part-of-parent-2108
subclass of: part-of-parent-2109
IAO_0000115: Endonucleolytic cleavage to separate a pre-SSU-rRNA from a pre-LSU-rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.

endonucleolytic cleavage between LSU-rRNA and 5S rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
type: Class
subclass of: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
subclass of: part-of-parent-2108
IAO_0000115: Endonucleolytic cleavage to separate a pre-LSU-rRNA from a pre-5S rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.

exonucleolytic trimming involved in rRNA processing
type: Class
subclass of: cleavage involved in rRNA processing
subclass of: GO_0090503
subclass of: part-of-parent-6364
IAO_0000115: Exonucleolytic digestion of a pre-rRNA molecule in the process to generate a mature rRNA molecule.
has related synonym: exonucleolytic trimming during rRNA processing

maturation of 5.8S rRNA
type: Class
subclass of: GO_0006364
IAO_0000115: Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule.

endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
type: Class
subclass of: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
subclass of: GO_0031125
subclass of: part-of-parent-462
IAO_0000115: Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA.
has related synonym: endonucleolytic cleavage at site D

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
type: Class
subclass of: GO_0030490
IAO_0000115: Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
has related synonym: maturation of 18S rRNA
replaces: GO_1990041

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
type: Class
subclass of: maturation of LSU-rRNA
IAO_0000115: Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.

endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
type: Class
subclass of: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
subclass of: part-of-parent-463
subclass of: part-of-parent-466
IAO_0000115: Endonucleolytic cleavage within Internal Transcribed Spacer 1 (ITS1) upstream of the 5.8S rRNA derived from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, this endonucleolytic cleavage within ITS1 initiates the maturation of the LSU and the 5.8S rRNAs.
has related synonym: endonucleolytic cleavage at A3

exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
type: Class
subclass of: exonucleolytic trimming involved in rRNA processing
subclass of: rRNA 5'-end processing
subclass of: part-of-parent-466
IAO_0000115: Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 5'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript.

maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
type: Class
subclass of: maturation of 5.8S rRNA
IAO_0000115: Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
type: Class
subclass of: exonucleolytic trimming involved in rRNA processing
subclass of: GO_0031125
subclass of: part-of-parent-466
IAO_0000115: Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript.

generation of mature 3'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
type: Class
subclass of: GO_0031125
subclass of: part-of-parent-463
IAO_0000115: Any process involved in generating the mature 3'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
has related synonym: processing at B2

cleavage involved in rRNA processing
type: Class
subclass of: GO_0090501
subclass of: part-of-parent-6364
IAO_0000115: Any phosphodiester bond hydrolysis involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule.
has related synonym: cleavage during rRNA processing

maturation of LSU-rRNA
type: Class
subclass of: GO_0006364
subclass of: part-of-parent-42273
IAO_0000115: Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule.

endonucleolytic cleavage in 3'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
type: Class
subclass of: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Endonucleolytic cleavage within the 3'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, endonucleolytic cleavage within the 3'-ETS of the pre-RNA, which may occur cotranscriptionally, is the first step in rRNA processing, and initiates a cascade of subsequent processing and modification events.

endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
type: Class
subclass of: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
subclass of: rRNA 5'-end processing
subclass of: part-of-parent-462
IAO_0000115: Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA.
has related synonym: endonucleolytic cleavage at A1

maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
type: Class
subclass of: maturation of LSU-rRNA
IAO_0000115: Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.

maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
type: Class
subclass of: GO_0030490
IAO_0000115: Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.

maturation of 2S rRNA
type: Class
subclass of: GO_0006364
IAO_0000115: Any process involved in the maturation of a precursor 2S ribosomal RNA (rRNA) molecule into a mature 2S rRNA molecule.

maturation of 4.5S rRNA
type: Class
subclass of: GO_0006364
IAO_0000115: Any process involved in the maturation of a precursor 4.5S ribosomal RNA (rRNA) molecule into a mature 4.5S rRNA molecule.

generation of mature 5'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
type: Class
subclass of: cleavage involved in rRNA processing
subclass of: rRNA 5'-end processing
subclass of: part-of-parent-463
IAO_0000115: Cleavage within ITS2 to generate the mature 5'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
has related synonym: processing at C1

endonucleolytic cleavage involved in rRNA processing
type: Class
subclass of: cleavage involved in rRNA processing
subclass of: GO_0090502
subclass of: part-of-parent-6364
IAO_0000115: Any endonucleolytic cleavage involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. Some endonucleolytic cleavages produce the mature end, while others are a step in the process of generating the mature end from the pre-rRNA.
has related synonym: endonucleolytic cleavage during rRNA processing

endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
type: Class
subclass of: endonucleolytic cleavage involved in rRNA processing
IAO_0000115: Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with three genes, in this order, are produced in the nuclei of many eukaryotic species, including S. cerevisiae.

endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
type: Class
subclass of: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
subclass of: part-of-parent-462
IAO_0000115: Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable.
has related synonym: endonucleolytic cleavage at A0
has related synonym: endonucleolytic cleavage at A-prime

maturation of 5S rRNA
type: Class
subclass of: GO_0006364
IAO_0000115: Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule.

maturation of 5S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
type: Class
subclass of: maturation of 5S rRNA
IAO_0000115: Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript.

endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
type: Class
subclass of: endonucleolytic cleavage involved in rRNA processing
IAO_0000115: Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the nuclei of D. melanogaster as well as in those of other dipteran species.

cleavage between SSU-rRNA and 5.8S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
type: Class
subclass of: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
subclass of: part-of-parent-474
subclass of: part-of-parent-487
IAO_0000115: Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.

cleavage between 2S rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
type: Class
subclass of: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
subclass of: part-of-parent-473
subclass of: part-of-parent-475
IAO_0000115: Endonucleolytic cleavage between the LSU-rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.

cleavage between 5.8S rRNA and 2S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
type: Class
subclass of: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
subclass of: part-of-parent-475
subclass of: part-of-parent-487
IAO_0000115: Endonucleolytic cleavage between the 5.8S rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.

maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
type: Class
subclass of: maturation of 5.8S rRNA
IAO_0000115: Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 8.8S rRNA, the 2S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.

maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
type: Class
subclass of: maturation of LSU-rRNA
IAO_0000115: Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript.

maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
type: Class
subclass of: GO_0030490
IAO_0000115: Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript.

small nucleolar ribonucleoprotein complex assembly
type: Class
subclass of: GO_0022618
IAO_0000115: The aggregation, arrangement and bonding together of proteins and a snoRNA to form a small nucleolar ribonucleoprotein (snoRNP) complex.
has exact synonym: snoRNP assembly

box C/D snoRNP assembly
type: Class
subclass of: small nucleolar ribonucleoprotein complex assembly
IAO_0000115: The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex.
has exact synonym: box C/D small nucleolar ribonucleoprotein complex assembly

box H/ACA snoRNP assembly
type: Class
subclass of: small nucleolar ribonucleoprotein complex assembly
IAO_0000115: The aggregation, arrangement and bonding together of proteins and a box H/ACA snoRNA to form a box H/ACA small nucleolar ribonucleoprotein (snoRNP) complex.
has exact synonym: box H/ACA small nucleolar ribonucleoprotein complex assembly

box C/D RNA 3'-end processing
type: Class
subclass of: GO_0031126
subclass of: GO_0034963
IAO_0000115: Any process involved in forming the mature 3' end of a box C/D RNA molecule.
has exact synonym: box C/D RNA 3' end processing
has related synonym: box C/D snoRNA 3'-end processing
has related synonym: box C/D sRNA 3'-end processing

box H/ACA RNA 3'-end processing
type: Class
subclass of: GO_0031126
subclass of: GO_0034964
IAO_0000115: Any process involved in forming the mature 3' end of a box H/ACA RNA molecule.
has exact synonym: box H/ACA RNA 3' end processing
has related synonym: box H/ACA snoRNA 3'-end processing
has related synonym: box H/ACA sRNA 3'-end processing

DNA template activity
type: Class
subclass of: DNA binding
subclass of: GO_0140489
IAO_0000115: Binding to nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target DNA molecule.
has related synonym: base pairing with DNA

RNA polymerase I upstream activating factor complex
type: Class
subclass of: RNA polymerase I transcription regulator complex
IAO_0000115: A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p.
has exact synonym: RNA polymerase I upstream activation factor complex
has exact synonym: UAF

proteasome complex
type: Class
subclass of: GO_0140535
subclass of: GO_1905369
IAO_0000115: A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
has related synonym: 26S proteasome
has exact synonym: proteasome

obsolete proteasome regulatory particle (sensu Bacteria)
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A multisubunit complex that recognizes and unfolds ubiquitinated proteins, and translocates them to the core complex in an ATP dependent manner. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2).

glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
type: Class
subclass of: GO_0098796
subclass of: GO_0140534
subclass of: GO_1990234
subclass of: part-of-parent-5789
IAO_0000115: An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast.
has exact synonym: GPI-GlcNAc transferase complex
has exact synonym: GPI-GnT complex
has exact synonym: GPI-N-acetylglucosaminyltransferase complex

H3-H4 histone complex chaperone activity
type: Class
subclass of: GO_0140713
IAO_0000115: A histone chaperone that carries a H3-H4 histone complex.
has exact synonym: H3-H4 histone carrier activity

H2A-H2B histone complex chaperone activity
type: Class
subclass of: GO_0140713
IAO_0000115: A histone chaperone that carries a H2A-H2B histone complex.
has exact synonym: H2A-H2B histone carrier activity

lncRNA-mediated gene silencing
type: Class
subclass of: GO_0035194
IAO_0000115: A post-transcriptional gene silencing pathway in which regulatory long noncoding RNAs (lncRNAs) elicit silencing of specific target genes, often miRNAs.

actin severing activator activity
type: Class
subclass of: GO_0140677
IAO_0000115: Binds to and increases the activity of a actin severing protein.

3-sulfino-L-alanine: proton, glutamate antiporter activity
type: Class
subclass of: GO_0008514
subclass of: GO_0015172
subclass of: GO_0015175
subclass of: GO_0015299
subclass of: GO_0072349
subclass of: GO_0140323
subclass of: GO_0140848
subclass of: GO_1901680
IAO_0000115: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 3-sulfino-L-alanine (cysteinesulfinate) (out) + H(+)(in) + L-glutamate(in) = 3-sulfino-L-alanine(in) + H(+)(out) + L-glutamate(out).

aspartate:glutamate, proton antiporter activity
type: Class
subclass of: GO_0005310
subclass of: GO_0015172
subclass of: GO_0015299
subclass of: GO_0015556
subclass of: GO_0140323
subclass of: GO_0140848
IAO_0000115: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H(+)(out) + L-aspartate(in) + L-glutamate(out) = H(+)(in) + L-aspartate(out) + L-glutamate(in).

embryonic axis specification
type: Class
subclass of: GO_0009798
subclass of: GO_0009880
IAO_0000115: The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo.
has related synonym: embryonic axis determination

mismatch base pair DNA N-glycosylase activity
type: Class
subclass of: GO_0019104
IAO_0000115: Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.

purine-specific mismatch base pair DNA N-glycosylase activity
type: Class
subclass of: mismatch base pair DNA N-glycosylase activity
IAO_0000115: Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site.
has related synonym: A/G-specific adenine DNA glycosylase activity

oxidized base lesion DNA N-glycosylase activity
type: Class
subclass of: GO_0019104
IAO_0000115: Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.

oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
type: Class
subclass of: oxidized base lesion DNA N-glycosylase activity
IAO_0000115: Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.
has related synonym: bifunctional DNA glycosylase
has related synonym: DNA glycosylase/AP-lyase
has related synonym: DNA glycosylase/beta-lyase
has related synonym: endodeoxyribonuclease III
has related synonym: endonuclease III
has related synonym: endonuclease VIII activity
has exact synonym: oxidized pyrimidine base lesion DNA N-glycosylase activity
has related synonym: pyrimidine-specific oxidized base lesion DNA N-glycosylase activity
replaces: GO_0019004

pyrimidine dimer DNA N-glycosylase activity
type: Class
subclass of: GO_0019104
IAO_0000115: Catalysis of the removal of pyrimidine dimers by removing the 5' pyrimidine of the dimer by cleaving the N-C1' glycosidic bond between the 5' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.

achiasmate meiosis I
type: Class
subclass of: GO_0007127
IAO_0000115: The first division of meiosis in which homologous chromosomes are paired and segregated from each other, occurring in the constitutive absence of chiasmata.
has exact synonym: achiasmate meiosis I nuclear division

meiotic DNA double-strand break processing
type: Class
subclass of: DNA double-strand break processing
subclass of: GO_1903046
subclass of: part-of-parent-51321
IAO_0000115: The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs. This takes place during meiosis.

meiotic DNA recombinase assembly
type: Class
subclass of: DNA recombinase assembly
subclass of: GO_0061982
IAO_0000115: During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA.

meiotic strand invasion
type: Class
subclass of: GO_0042148
subclass of: GO_0061982
subclass of: part-of-parent-51321
IAO_0000115: The cell cycle process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. This occurs during meiosis.
has related synonym: meiotic displacement loop biosynthesis
has related synonym: meiotic displacement loop formation
has related synonym: meiotic D-loop biosynthesis
has related synonym: meiotic D-loop formation

meiotic joint molecule formation
type: Class
subclass of: GO_1903046
subclass of: part-of-parent-7131
IAO_0000115: The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. These joint molecules contain Holliday junctions on either side of heteroduplex DNA.

meiotic mismatch repair
type: Class
subclass of: GO_0006298
subclass of: GO_0061982
IAO_0000115: A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis.

meiotic DNA repair synthesis
type: Class
subclass of: DNA synthesis involved in DNA repair
subclass of: GO_0061982
IAO_0000115: During meiosis, the synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template.

resolution of meiotic recombination intermediates
type: Class
subclass of: GO_0061982
subclass of: part-of-parent-7131
subclass of: part-of-parent-51307
IAO_0000115: The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged.
has related synonym: resolution of meiotic joint molecules as recombinants

meiotic heteroduplex formation
type: Class
subclass of: GO_0061982
subclass of: part-of-parent-6310
IAO_0000115: During meiosis, the formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules.

meiotic strand displacement
type: Class
subclass of: strand displacement
subclass of: GO_0061982
IAO_0000115: The cell cycle process in which the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA is rejected. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. This occurs during meiosis.
has related synonym: meiotic displacement loop dissociation
has related synonym: meiotic displacement loop processing
has related synonym: meiotic D-loop dissociation
has related synonym: meiotic D-loop processing

nucleotide-excision repair, DNA damage recognition
type: Class
subclass of: GO_0051276
subclass of: part-of-parent-6289
IAO_0000115: The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix.
has related synonym: pyrimidine-dimer repair, DNA damage recognition

transcription-coupled nucleotide-excision repair, DNA damage recognition
type: Class
subclass of: nucleotide-excision repair, DNA damage recognition
subclass of: part-of-parent-6283
IAO_0000115: The identification of lesions on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway.
has related synonym: pyrimidine-dimer repair, DNA damage recognition

nucleotide-excision repair, DNA duplex unwinding
type: Class
subclass of: GO_0032508
subclass of: part-of-parent-6289
IAO_0000115: The unwinding, or local denaturation, of the DNA duplex to create a bubble around the site of the DNA damage.

nucleotide-excision repair, DNA damage removal
type: Class
subclass of: GO_0044349
subclass of: part-of-parent-6289
IAO_0000115: The removal of the oligonucleotide that contains the DNA damage. The oligonucleotide is formed by dual incisions that flank the site of DNA damage.

photoreactive repair
type: Class
subclass of: GO_0006290
IAO_0000115: The repair of UV-induced T-T, C-T and C-C dimers by directly reversing the damage to restore the original pyrimidines.
has related synonym: pyrimidine-dimer repair by photolyase

pyrimidine dimer repair by nucleotide-excision repair
type: Class
subclass of: GO_0006289
subclass of: GO_0006290
IAO_0000115: The repair of UV-induced T-T, C-T, and C-C dimers by the recognition and removal of the damaged DNA strand from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.

(R,R)-butanediol dehydrogenase activity
type: Class
subclass of: GO_0016616
IAO_0000115: Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H(+).
has related synonym: (R)-2,3-butanediol dehydrogenase activity
has related synonym: (R)-diacetyl reductase activity
has related synonym: 1-amino-2-propanol dehydrogenase activity
has related synonym: 1-amino-2-propanol oxidoreductase activity
has related synonym: 2,3-butanediol dehydrogenase activity
has related synonym: aminopropanol oxidoreductase activity
has related synonym: butyleneglycol dehydrogenase activity
has related synonym: butylene glycol dehydrogenase activity
has related synonym: D-(-)-butanediol dehydrogenase activity
has related synonym: D-1-amino-2-propanol:NAD(2) oxidoreductase activity
has related synonym: D-1-amino-2-propanol dehydrogenase activity
has related synonym: D-aminopropanol dehydrogenase activity
has related synonym: D-butanediol dehydrogenase activity
has related synonym: diacetyl (acetoin) reductase activity

telomere maintenance via recombination
type: Class
subclass of: telomere maintenance
subclass of: GO_0006312
IAO_0000115: Any recombinational process that contributes to the maintenance of proper telomeric length.
has related synonym: telomerase-independent telomere maintenance

telomere maintenance
type: Class
subclass of: GO_0006259
subclass of: GO_0032200
IAO_0000115: Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.
has related synonym: regulation of telomere length

double-strand break repair via homologous recombination
type: Class
subclass of: recombinational repair
subclass of: GO_0006302
IAO_0000115: The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
has exact synonym: HDR
has exact synonym: homologous recombinational repair
has exact synonym: homology-directed repair
has exact synonym: HRR
has exact synonym: Rad51-dependent recombinational repair
has exact synonym: Rhp51-dependent recombinational repair
replaces: GO_0016924

recombinational repair
type: Class
subclass of: GO_0006281
subclass of: GO_0006310
IAO_0000115: A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region.

obsolete non-recombinational repair
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A DNA repair process in which that does not require the exchange of genetic material between the broken DNA molecule and a homologous DNA region.

double-strand break repair via break-induced replication
type: Class
subclass of: double-strand break repair via homologous recombination
IAO_0000115: The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome.

DNA double-strand break processing
type: Class
subclass of: GO_0006259
subclass of: part-of-parent-6302
IAO_0000115: The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang.

DNA recombinase assembly
type: Class
subclass of: GO_0065004
subclass of: GO_0090735
subclass of: part-of-parent-45003
IAO_0000115: The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA.
has exact synonym: Rad51 nucleoprotein filament formation

DNA synthesis involved in DNA repair
type: Class
subclass of: GO_0071897
subclass of: part-of-parent-6281
IAO_0000115: Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template.
has related synonym: DNA repair synthesis
has related synonym: DNA synthesis during DNA repair
has related synonym: mitotic DNA repair synthesis

strand displacement
type: Class
subclass of: GO_0006259
subclass of: part-of-parent-6310
IAO_0000115: The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules.
has related synonym: displacement loop dissociation
has related synonym: displacement loop processing
has related synonym: D-loop dissociation
has related synonym: D-loop processing

obsolete DNA strand renaturation
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The identification and annealing of complementary base pairs in single-strand DNA.

removal of nonhomologous ends
type: Class
subclass of: GO_0006259
IAO_0000115: The removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur.

double-strand break repair via single-strand annealing, removal of nonhomologous ends
type: Class
subclass of: removal of nonhomologous ends
subclass of: part-of-parent-45002
IAO_0000115: During DSBR via single-strand annealing, the removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur.

DNA catabolic process, endonucleolytic
type: Class
subclass of: GO_0006308
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.
has exact synonym: DNA breakdown, endonucleolytic
has exact synonym: DNA degradation, endonucleolytic
has exact synonym: endonucleolytic degradation of DNA
has exact synonym: endonucleolytic DNA catabolism

DNA catabolic process, exonucleolytic
type: Class
subclass of: GO_0006308
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.
has exact synonym: DNA breakdown, exonucleolytic
has exact synonym: DNA degradation, exonucleolytic
has exact synonym: exonucleolytic degradation of DNA

obsolete DNA strand annealing activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Facilitates the base-pairing of complementary single-stranded DNA.

nuclear membrane fusion
type: Class
subclass of: GO_0071763
subclass of: GO_0090174
IAO_0000115: The joining of 2 or more lipid bilayer membranes that surround the nucleus.

karyogamy
type: Class
subclass of: GO_0006997
subclass of: GO_0048284
subclass of: part-of-parent-6997
IAO_0000115: The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei.
has exact synonym: nuclear fusion
has exact synonym: nuclear fusion during karyogamy
replaces: GO_0007335

karyogamy involved in conjugation with cellular fusion
type: Class
subclass of: karyogamy
subclass of: GO_0022414
subclass of: part-of-parent-747
IAO_0000115: During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after cytogamy.
has related synonym: karyogamy during conjugation with cellular fusion

nuclear migration involved in conjugation with cellular fusion
type: Class
subclass of: GO_0022414
subclass of: GO_0030473
subclass of: part-of-parent-747
IAO_0000115: The microtubule-based movement of nuclei towards one another as a prelude to karyogamy in organisms undergoing conjugation with cellular fusion.
has exact synonym: nuclear congression
has related synonym: nuclear migration during conjugation with cellular fusion
replaces: GO_0006946

karyogamy involved in conjugation with mutual genetic exchange
type: Class
subclass of: karyogamy
subclass of: GO_0022414
subclass of: part-of-parent-748
IAO_0000115: During sexual reproduction, the creation of a single nucleus from two nuclei as a result of fusing the nuclear envelopes that surround each nuclei. This takes place following the mutual exchange of one of the two nuclei produced by the mitosis that follows the second meiotic nuclear division. This occurs in ciliated protozoans such as Tetrahymena.
has exact synonym: karyogamy involved in conjugation without cellular fusion

nuclear migration involved in conjugation with mutual genetic exchange
type: Class
subclass of: GO_0007097
subclass of: GO_0022414
subclass of: part-of-parent-744
subclass of: part-of-parent-748
IAO_0000115: The net movement of nuclei towards one another, leading to the bilateral transfer of genetic material in organisms undergoing conjugation without cellular fusion.
has related synonym: nuclear exchange during conjugation without cellular fusion
has exact synonym: nuclear migration involved in conjugation without cellular fusion

obsolete conjugation
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms.

conjugation with cellular fusion
type: Class
subclass of: GO_0019953
IAO_0000115: A conjugation process that results in the union of cellular and genetic information from compatible mating types. An example of this process is found in Saccharomyces cerevisiae.
has related synonym: cell fusion
has related synonym: mating
replaces: GO_0007322
replaces: GO_0007333
replaces: GO_0030461
replaces: GO_0030477

conjugation with mutual genetic exchange
type: Class
subclass of: GO_0019953
IAO_0000115: A conjugation process that results in the mutual exchange and union of only genetic information between compatible mating types. Conjugation without cellular fusion requires direct cellular contact between the organisms without plasma membrane fusion. The organisms involved in conjugation without cellular fusion separate after nuclear exchange.
has exact synonym: conjugation without cellular fusion

response to pheromone triggering conjugation with cellular fusion
type: Class
subclass of: GO_0071444
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that positively regulates the process of conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae.
has related synonym: response to pheromone during conjugation with cellular fusion
replaces: GO_0007328
replaces: GO_0030434

pheromone-dependent signal transduction involved in conjugation with cellular fusion
type: Class
subclass of: GO_0032005
subclass of: part-of-parent-749
IAO_0000115: A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae.
has related synonym: transduction of mating signal
replaces: GO_0007330
replaces: GO_0030454

mitotic cell cycle G1 arrest in response to pheromone
type: Class
subclass of: GO_0045930
subclass of: part-of-parent-749
IAO_0000115: The cell cycle regulatory process in which the mitotic cell cycle is halted during G1 as a result of a pheromone stimulus. An example of this process is found in Saccharomyces cerevisiae.
has related synonym: cell cycle arrest in response to pheromone
replaces: GO_0030571

agglutination involved in conjugation with cellular fusion
type: Class
subclass of: GO_0022414
subclass of: GO_0051703
subclass of: GO_0098609
subclass of: part-of-parent-747
subclass of: part-of-parent-749
IAO_0000115: The aggregation or adhesion of compatible mating types via complementary cell-cell interactions during conjugation with cellular fusion of a unicellular organism. An example of this process is agglutination in Saccharomyces cerevisiae.
has related synonym: agglutination
has exact synonym: cell-cell adhesion during conjugation with cellular fusion
has exact synonym: cell-cell adhesion during mating
replaces: GO_0007334

cell morphogenesis involved in conjugation with cellular fusion
type: Class
subclass of: cell morphogenesis
subclass of: developmental process involved in reproduction
subclass of: part-of-parent-747
IAO_0000115: The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation cellular fusion.
has related synonym: shmooing
has related synonym: shmoo orientation
replaces: GO_0007332

adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion
type: Class
subclass of: GO_0023058
subclass of: part-of-parent-749
IAO_0000115: In organisms that undergo conjugation with cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. An example of this is the adaptation to pheromone during conjugation with cellular fusion in Saccharomyces cerevisiae.
has exact synonym: adaptation of signalling pathway by response to pheromone involved in conjugation with cellular fusion
has related synonym: adaptation to pheromone during conjugation with cellular fusion
has exact synonym: desensitization to pheromone during conjugation with cellular fusion
replaces: GO_0007331
replaces: GO_0030453

cytogamy
type: Class
subclass of: GO_0022413
subclass of: part-of-parent-747
IAO_0000115: During conjugation with cellular fusion, the process resulting in creating a single cell from complementary mating types. The localized remodeling and dissolution of external protective structures allow the fusion of the plasma membranes and cytoplasmic mixing. An example of this process is found in Saccharomyces cerevisiae.
has related synonym: zygote formation
replaces: GO_0000218
replaces: GO_0030462

response to pheromone regulating conjugation with mutual genetic exchange
type: Class
subclass of: GO_0007154
subclass of: GO_0071444
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus regulating the process of conjugation without cellular fusion.
has exact synonym: response to pheromone triggering conjugation without cellular fusion

obsolete signal transduction involved in regulation of conjugation with mutual genetic exchange
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation without cellular fusion.

agglutination involved in conjugation with mutual genetic exchange
type: Class
subclass of: GO_0051703
subclass of: GO_0098609
subclass of: part-of-parent-756
IAO_0000115: The aggregation or adhesion of compatible mating types via complementary cell-cell interactions during conjugation without cellular fusion of a unicellular organism.
has exact synonym: agglutination involved in conjugation without cellular fusion
has exact synonym: sexual flocculation

obsolete cell morphogenesis involved in conjugation with mutual genetic exchange
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation without cellular fusion.

adaptation to pheromone regulating conjugation with mutual genetic exchange
type: Class
subclass of: response to pheromone regulating conjugation with mutual genetic exchange
subclass of: GO_0022401
IAO_0000115: In organisms that undergo conjugation without cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses.
has related synonym: adaptation to pheromone involved conjugation without cellular fusion
has exact synonym: desensitization to pheromone during conjugation without cellular fusion

conjugant formation
type: Class
subclass of: GO_0022414
subclass of: GO_0098610
subclass of: part-of-parent-748
IAO_0000115: During conjugation without cellular fusion, the process that results in pairing complementary mating types. Localized morphological, cytological, and cytoskeletal changes connect the mating types without cytoplasmic mixing.

pheromone-induced unidirectional conjugation
type: Class
subclass of: GO_0009291
IAO_0000115: Unidirectional transfer of genetic information triggered by to a pheromone signal.

obsolete cell morphogenesis involved in unidirectional conjugation
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo unidirectional conjugation.

obsolete cellular morphogenesis involved in pheromone-induced unidirectional conjugation
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The change in form (cell shape and size) that contributes to sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo pheromone-induced unidirectional conjugation.

response to pheromone regulating pheromone-induced unidirectional conjugation
type: Class
subclass of: GO_0019236
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that regulates the process of pheromone-induced unidirectional conjugation.
has related synonym: response to pheromone during pheromone-induced unidirectional

negative adaptation of signaling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation
type: Class
subclass of: GO_0022401
subclass of: part-of-parent-765
IAO_0000115: In organisms that undergo pheromone-induced unidirectional conjugation, the process involved in desensitization following exposure to pheromone stimulus that acts to down-regulate further stimulation or block initial conjugation responses.
has related synonym: adaptation to pheromone during pheromone-induced unidirectional conjugation
has exact synonym: desensitization to pheromone during pheromone-induced unidirectional conjugation
has exact synonym: negative adaptation of signalling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation

obsolete cell morphogenesis involved in conjugation
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types.

syncytium formation by plasma membrane fusion
type: Class
subclass of: GO_0006949
subclass of: GO_0140253
IAO_0000115: The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.
has related synonym: cell fusion

syncytium formation by mitosis without cytokinesis
type: Class
subclass of: GO_0006949
IAO_0000115: The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by one or more rounds of nuclear division without cytokinesis.
has related synonym: syncytium formation by mitosis without cell division

peptide pheromone export
type: Class
subclass of: GO_0009914
subclass of: GO_0015833
IAO_0000115: The directed movement of a peptide pheromone out of a cell by a secretion or export pathway used solely for the export of peptide pheromones.
has related synonym: a-factor export
replaces: GO_0007325

obsolete agglutination involved in conjugation
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The aggregation or adhesion of compatible mating types via complementary cell-cell interactions prior to the formation of irreversible cellular contacts during conjugation.

mating pheromone activity
type: Class
subclass of: GO_0005186
IAO_0000115: The activity of binding to and activating specific cell surface receptors, thereby inducing a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells. The mating pheromone can either be retained on the cell surface or secreted.

phosphatidyl-N-methylethanolamine N-methyltransferase activity
type: Class
subclass of: GO_0008170
subclass of: GO_0008757
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine.
has related synonym: methyltransferase II
has related synonym: phosphatidylethanolamine methyltransferase I
has related synonym: phosphatidylmonomethylethanolamine methyltransferase activity
has related synonym: phosphatidyl-N-methylethanolamine methyltransferase activity
has related synonym: phosphatidyl-N-monomethylethanolamine methyltransferase activity
has related synonym: phospholipid methyltransferase activity
has exact synonym: PLMT
has related synonym: S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase activity

adenyl-nucleotide exchange factor activity
type: Class
subclass of: GO_0030554
subclass of: GO_0060590
IAO_0000115: Binds to and stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins.

chromosome, centromeric region
type: Class
subclass of: GO_0098687
IAO_0000115: The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
has related synonym: centromere
has exact synonym: centromere complex
has exact synonym: chromosome, centric region
has related synonym: chromosome, pericentric region
replaces: GO_0097521

kinetochore
type: Class
subclass of: GO_0043232
subclass of: GO_0099080
subclass of: part-of-parent-779
IAO_0000115: A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
has exact synonym: condensed chromosome kinetochore
has exact synonym: condensed nuclear chromosome kinetochore
replaces: GO_0000777
replaces: GO_0000778
replaces: GO_0005699

condensed chromosome, centromeric region
type: Class
subclass of: chromosome, centromeric region
subclass of: part-of-parent-793
IAO_0000115: The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
has exact synonym: condensed chromosome, centric region
has related synonym: condensed chromosome, centromere
has related synonym: condensed chromosome, pericentric region
has related synonym: condensed nuclear chromosome, centromeric region
replaces: GO_0000780

chromosome, telomeric region
type: Class
subclass of: GO_0098687
IAO_0000115: The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres).
has related synonym: nuclear chromosome, telomere
has related synonym: nuclear chromosome, telomeric region
has related synonym: telomere
replaces: GO_0000784

telomere cap complex
type: Class
subclass of: GO_0032993
subclass of: GO_0044815
subclass of: part-of-parent-140445
IAO_0000115: A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome.

nuclear telomere cap complex
type: Class
subclass of: telomere cap complex
subclass of: GO_0140513
IAO_0000115: A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome.

chromatin
type: Class
subclass of: GO_0110165
subclass of: part-of-parent-5694
IAO_0000115: The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
has related synonym: chromosome scaffold
has related synonym: cytoplasmic chromatin
has related synonym: nuclear chromatin
replaces: GO_0000789
replaces: GO_0000790
replaces: GO_0005717

nucleosome
type: Class
subclass of: GO_0032993
subclass of: GO_0044815
subclass of: part-of-parent-785
IAO_0000115: A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.
has related synonym: cytoplasmic nucleosome
has related synonym: nuclear nucleosome
replaces: GO_0000787
replaces: GO_0000788
replaces: GO_0005718

euchromatin
type: Class
subclass of: chromatin
IAO_0000115: A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation.
has related synonym: nuclear euchromatin
has exact synonym: transcriptionally active chromatin
replaces: GO_0005719
replaces: GO_0035327

heterochromatin
type: Class
subclass of: chromatin
IAO_0000115: A compact and highly condensed form of chromatin that is refractory to transcription.
has related synonym: nuclear heterochromatin
has exact synonym: transcriptionally inactive chromatin
has exact synonym: transcriptionally silent chromatin
replaces: GO_0005720
replaces: GO_0035328

condensed chromosome
type: Class
subclass of: GO_0005694
IAO_0000115: A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.
has related synonym: cytoplasmic mitotic chromosome
has related synonym: metaphase chromosome
has related synonym: mitotic chromosome

condensed nuclear chromosome
type: Class
subclass of: nuclear chromosome
subclass of: condensed chromosome
subclass of: part-of-parent-5634
IAO_0000115: A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.
has related synonym: meiotic chromosome
has related synonym: nuclear mitotic chromosome

synaptonemal complex
type: Class
subclass of: GO_0099086
IAO_0000115: A proteinaceous scaffold found between homologous chromosomes during meiosis. It consists of 2 lateral elements and a central element, all running parallel to each other. Transverse filaments connect the lateral elements to the central element.
replaces: GO_0005716

condensin complex
type: Class
subclass of: GO_0044815
subclass of: part-of-parent-5694
IAO_0000115: A multisubunit protein complex that plays a central role in chromosome condensation in meiosis and mitosis.
has related synonym: 13S condensin complex
has related synonym: 8S condensin complex
has related synonym: condensin core heterodimer
has related synonym: condensin I complex
has related synonym: nuclear condensin complex
has related synonym: Smc2-Smc4 complex
has related synonym: SMC complex
replaces: GO_0000797
replaces: GO_0000799
replaces: GO_0005676
replaces: GO_0008620
replaces: GO_0008621
replaces: GO_0061814

lateral element
type: Class
subclass of: GO_0110165
subclass of: part-of-parent-795
IAO_0000115: A proteinaceous core found between sister chromatids during meiotic prophase.
has exact synonym: axial element

central element
type: Class
subclass of: GO_0110165
subclass of: part-of-parent-795
IAO_0000115: A structural unit of the synaptonemal complex found between the lateral elements.

transverse filament
type: Class
subclass of: GO_0110165
subclass of: part-of-parent-795
IAO_0000115: A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them.

sex chromosome
type: Class
subclass of: GO_0005694
IAO_0000115: A chromosome involved in sex determination.

W chromosome
type: Class
subclass of: sex chromosome
IAO_0000115: The sex chromosome present in females of species in which the female is the heterogametic sex; generally, the sex chromosome that pairs with the Z chromosome in the heterogametic sex. The W chromosome is absent from the cells of males and present in one copy in the somatic cells of females.

X chromosome
type: Class
subclass of: sex chromosome
IAO_0000115: The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males.

Y chromosome
type: Class
subclass of: sex chromosome
IAO_0000115: The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males.

Z chromosome
type: Class
subclass of: sex chromosome
IAO_0000115: The sex chromosome present in both sexes of species in which the female is the heterogametic sex. Two copies of the Z chromosome are present in each somatic cell of males and one copy is present in females.

origin recognition complex
type: Class
subclass of: GO_0032991
subclass of: part-of-parent-5694
IAO_0000115: A multisubunit complex that is located at the replication origins of a chromosome.
has exact synonym: ORC
has exact synonym: origin of replication recognition complex

cytoplasmic origin of replication recognition complex
type: Class
subclass of: origin recognition complex
subclass of: part-of-parent-5737
IAO_0000115: A multisubunit complex that is located at the replication origins of a chromosome in the cytoplasm.
has exact synonym: cytoplasmic ORC
has related synonym: prokaryotic ORC

diacylglycerol diphosphate phosphatase activity
type: Class
subclass of: GO_0016462
IAO_0000115: Catalysis of the reaction: a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycerol 3-phosphate + phosphate.
has exact synonym: DGPP phosphatase activity
has exact synonym: DGPP phosphohydrolase activity
has exact synonym: diacylglycerol pyrophosphate phosphatase activity

GINS complex
type: Class
subclass of: GO_0031261
subclass of: part-of-parent-228
IAO_0000115: A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks.
has exact synonym: Go, Ichi, Ni and San complex

Swr1 complex
type: Class
subclass of: histone deacetylase complex
subclass of: GO_0097346
subclass of: part-of-parent-228
IAO_0000115: A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits.
has exact synonym: SWR-C

ESCRT I complex
type: Class
subclass of: GO_0036452
subclass of: GO_0098796
subclass of: part-of-parent-10008
IAO_0000115: An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes.
has related synonym: endosomal sorting complex required for transport

ESCRT II complex
type: Class
subclass of: GO_0036452
subclass of: GO_0098796
subclass of: part-of-parent-10008
IAO_0000115: An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes.
has related synonym: endosomal sorting complex required for transport

ESCRT III complex
type: Class
subclass of: GO_0036452
subclass of: GO_0098796
subclass of: part-of-parent-10008
IAO_0000115: A complex with membrane scission activity that plays a major role in many processes where membranes are remodelled - including endosomal transport (vesicle budding), nuclear envelope organisation (membrane closure, mitotic bridge cleavage), and cytokinesis (abscission).
has related synonym: endosomal sorting complex required for transport

COMA complex
type: Class
subclass of: GO_0140513
subclass of: part-of-parent-228
subclass of: part-of-parent-776
IAO_0000115: A kinetochore multiprotein complex that bridges the subunits that are in contact with centromeric DNA and the subunits bound to microtubules during kinetochore assembly. In yeast, consists of Ctf19p, Okp1p, Mcm21p, and Ame1p.
has exact synonym: Ctf19p-Okp1p-Mcm1p-Ame1p complex

nuclear MIS12/MIND complex
type: Class
subclass of: MIS12/MIND type complex
subclass of: GO_0140513
IAO_0000115: A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore of a chromosome in the nucleus. It helps to recruit outer kinetochore subunits that will bind to microtubules. Nuclear localization arises in some organisms because the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1.
has exact synonym: MIND complex
has exact synonym: Mtw1p Including Nnf1p-Nsl1p-Dsn1p complex

sister chromatid segregation
type: Class
subclass of: GO_0051276
subclass of: GO_0098813
IAO_0000115: The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets.

regulation of glutamine family amino acid metabolic process
type: Class
subclass of: GO_0006521
IAO_0000115: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.
has exact synonym: regulation of glutamine family amino acid metabolism

regulation of arginine metabolic process
type: Class
subclass of: regulation of glutamine family amino acid metabolic process
IAO_0000115: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
has exact synonym: regulation of arginine metabolism

inositol hexakisphosphate binding
type: Class
subclass of: GO_0043168
subclass of: GO_0043178
IAO_0000115: Binding to inositol hexakisphosphate.
has exact synonym: InsP6 binding
has exact synonym: IP6 binding

inositol-1,4,5-trisphosphate 6-kinase activity
type: Class
subclass of: GO_0051766
IAO_0000115: Catalysis of the reaction: D-myo-inositol 1,4,5-trisphosphate + ATP = D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + 2 H(+).
has exact synonym: ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase activity
has related synonym: inositol polyphosphate multikinase activity
has related synonym: inositol trisphosphate 6-kinase activity
has related synonym: IpmK

inositol tetrakisphosphate 3-kinase activity
type: Class
subclass of: GO_0051765
IAO_0000115: Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.
has exact synonym: 1D-myo-inositol-tetrakisphosphate 3-kinase activity
has related synonym: EC:2.7.1.151
has exact synonym: inositol 1,4,5,6-tetrakisphosphate 3-kinase activity
has related synonym: inositol polyphosphate multikinase activity
has related synonym: IpmK

inositol tetrakisphosphate 6-kinase activity
type: Class
subclass of: GO_0051765
IAO_0000115: Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP.
has exact synonym: 1D-myo-inositol-tetrakisphosphate 6-kinase activity
has exact synonym: inositol 1,3,4,5-tetrakisphosphate 6-kinase activity

obsolete inositol pyrophosphate synthase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the phosphorylation of inositol phosphates which possess diphosphate bonds.

inositol-1,3,4,5,6-pentakisphosphate kinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016776
IAO_0000115: Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown.

inositol hexakisphosphate kinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016776
IAO_0000115: Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown.

inositol heptakisphosphate kinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016776
IAO_0000115: Catalysis of the reaction: ATP + diphospho-1D-myo-inositol-pentakisphosphate = ADP + bis(diphospho)-1D-myo-inositol-tetrakisphosphate. The isomeric configurations of the diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) and bis(diphospho)-1D-myo-inositol-tetrakisphosphate (bis-PP-IP4) are unknown.

inositol hexakisphosphate 4-kinase activity
type: Class
subclass of: inositol hexakisphosphate kinase activity
IAO_0000115: Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate.

inositol hexakisphosphate 6-kinase activity
type: Class
subclass of: inositol hexakisphosphate kinase activity
IAO_0000115: Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate.

inositol hexakisphosphate 5-kinase activity
type: Class
subclass of: inositol hexakisphosphate kinase activity
IAO_0000115: Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate.
has exact synonym: ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase activity

inositol heptakisphosphate 4-kinase activity
type: Class
subclass of: inositol heptakisphosphate kinase activity
IAO_0000115: Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate.
has exact synonym: diphosphoinositol-pentakisphosphate 4-kinase activity
has exact synonym: IP7 4-kinase activity

inositol heptakisphosphate 6-kinase activity
type: Class
subclass of: inositol heptakisphosphate kinase activity
IAO_0000115: Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate.

ER ubiquitin ligase complex
type: Class
subclass of: cytoplasmic ubiquitin ligase complex
subclass of: GO_0098796
subclass of: GO_0140534
subclass of: part-of-parent-5783
subclass of: part-of-parent-5789
IAO_0000115: A ubiquitin ligase complex found in the ER.

Hrd1p ubiquitin ligase complex
type: Class
subclass of: ER ubiquitin ligase complex
IAO_0000115: A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. In mammals, this complex contains the ubiquitin ligase HRD1 (Synoviolin) or AMFR (gp78).
has related synonym: HRD1 ubiquitin ligase complex

Doa10p ubiquitin ligase complex
type: Class
subclass of: ER ubiquitin ligase complex
IAO_0000115: A multiprotein complex that recognizes and ubiquitinates membrane proteins with misfolded cytosolic domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Ssm4p/Doa10p.
has exact synonym: Ssm4p ubiquitin ligase complex

Hrd1p ubiquitin ligase ERAD-M complex
type: Class
subclass of: Hrd1p ubiquitin ligase complex
IAO_0000115: A multiprotein complex that recognizes and ubiquitinates proteins with misfolded membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p.

Hrd1p ubiquitin ligase ERAD-L complex
type: Class
subclass of: Hrd1p ubiquitin ligase complex
IAO_0000115: A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p.

mRNA regulatory element binding translation repressor activity
type: Class
subclass of: GO_0030371
subclass of: GO_0090079
IAO_0000115: Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid.
has exact synonym: translation repressor activity, mRNA regulatory element binding
has related synonym: translation repressor activity, nucleic acid binding

translation repressor activity, non-nucleic acid binding
type: Class
subclass of: GO_0030371
subclass of: GO_0045183
IAO_0000115: Antagonizes the ribosome-mediated translation of mRNA into a polypeptide but does not bind directly to nucleic acid.

cell morphogenesis
type: Class
subclass of: GO_0009653
IAO_0000115: The developmental process in which the size or shape of a cell is generated and organized.
has exact synonym: cellular morphogenesis
replaces: GO_0007148
replaces: GO_0045790
replaces: GO_0045791

obsolete regulation of cell shape during vegetative growth phase
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any process that modulates the surface configuration of a cell during the vegetative growth phase. The vegetative growth phase is the growth phase during which single celled organisms reproduce by budding or other asexual methods.
replaces: GO_0090061

cell morphogenesis involved in differentiation
type: Class
subclass of: cell morphogenesis
subclass of: part-of-parent-48468
IAO_0000115: The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.

sporocarp development involved in asexual reproduction
type: Class
subclass of: GO_0030584
subclass of: part-of-parent-19954
IAO_0000115: The formation of a spore-bearing structure by fungus where spores will arise from asexual reproduction.
has related synonym: conidium development
has related synonym: fruiting body formation involved in asexual reproduction
has related synonym: haploid fruiting
has related synonym: homokaryotic fruiting
has related synonym: imperfect stage fruiting body development
has related synonym: monokaryotic fruiting

6,7-dimethyl-8-ribityllumazine synthase activity
type: Class
subclass of: GO_0016765
IAO_0000115: Catalysis of the reaction: 3,4-dihydroxy-2-butanone-4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate.
has related synonym: lumazine synthase activity

sulfonate dioxygenase activity
type: Class
subclass of: GO_0016706
IAO_0000115: Catalysis of the reaction: sulfonate + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2.
has exact synonym: sulfonate/alpha-ketoglutarate dioxygenase activity
has exact synonym: sulphonate dioxygenase activity

taurine dioxygenase activity
type: Class
subclass of: GO_0016706
IAO_0000115: Catalysis of the reaction: 2-oxoglutarate + O(2) + taurine = aminoacetaldehyde + CO(2) + succinate + sulfite.
has related synonym: 2-aminoethanesulfonate dioxygenase activity
has related synonym: alpha-ketoglutarate-dependent taurine dioxygenase activity
has related synonym: taurine, 2-oxoglutarate:O2 oxidoreductase (sulfite-forming)

sporocarp development involved in sexual reproduction
type: Class
subclass of: GO_0030584
subclass of: part-of-parent-19953
IAO_0000115: The process whose specific outcome is the progression of a fruiting body organ over time, from its formation to the mature structure. The fruiting body is a spore bearing structure. In fungi, the sporocarp (also known as fruiting body) is a multicellular structure on which spore-producing structures, such as basidia or asci, are borne. The fruiting body is part of the sexual phase of a fungal life cycle, with the rest of the life cycle being characterized by vegetative mycelial growth. The sporocarp of a basidiomycete is known as a basidiocarp, while the fruiting body of an ascomycete is known as an ascocarp. A significant range of different shapes and morphologies is found in both basidiocarps and ascocarps; these features play an important role in the identification and taxonomy of fungi.
has related synonym: ascus development
has related synonym: fruiting body development involved in sexual reproduction
has related synonym: fruiting body formation involved in sexual reproduction
has related synonym: perfect stage fruiting body development

cytokinesis
type: Class
subclass of: GO_0022402
subclass of: part-of-parent-51301
IAO_0000115: The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells.
has exact synonym: cell cycle cytokinesis
has exact synonym: cytokinesis involved in cell cycle
replaces: GO_0007104
replaces: GO_0016288
replaces: GO_0033205

cytokinesis by cell plate formation
type: Class
subclass of: cytokinesis
IAO_0000115: The process of dividing the cytoplasm of a parent cell where a structure forms in the cytoplasm and grows until reaching the plasma membrane, thereby completely separating the cytoplasms of adjacent progeny cells. An example of this is found in Arabidopsis thaliana.

assembly of actomyosin apparatus involved in cytokinesis
type: Class
subclass of: GO_0022607
subclass of: GO_0032506
subclass of: part-of-parent-61640
IAO_0000115: The assembly and arrangement of an apparatus composed of actin, myosin, and associated proteins that will function in cytokinesis.
has exact synonym: actomyosin apparatus assembly involved in cytokinesis
has exact synonym: cytokinesis, formation of actomyosin apparatus
has related synonym: formation of actomyosin apparatus involved in cytokinesis

preprophase band assembly
type: Class
subclass of: GO_0022402
subclass of: GO_0022607
subclass of: part-of-parent-911
IAO_0000115: The aggregation, arrangement and bonding together of a set of components to form the preprophase band, a dense band of microtubules that marks the position in the cell where cytokinesis will occur in cells that perform cytokinesis by cell plate formation.
has related synonym: preprophase band formation

phragmoplast assembly
type: Class
subclass of: GO_1902407
subclass of: part-of-parent-911
IAO_0000115: The formation of a structure composed of actin, myosin, and associated proteins that will function in cytokinesis in cells that perform cytokinesis by cell plate formation. The structure usually contains antiparallel microtubules and membrane (often visible as vesicles).
has related synonym: phragmoplast formation

actomyosin contractile ring assembly
type: Class
subclass of: assembly of actomyosin apparatus involved in cytokinesis
subclass of: GO_0044837
IAO_0000115: The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis.
has related synonym: constriction ring assembly
has exact synonym: contractile ring assembly
has exact synonym: cytokinesis, actomyosin contractile ring assembly
has related synonym: cytokinesis, actomyosin contractile ring formation
has related synonym: cytokinesis, actomyosin ring biosynthesis
has related synonym: cytokinesis, actomyosin ring formation
has related synonym: cytokinesis, contractile ring assembly
replaces: GO_0045573

actomyosin contractile ring contraction
type: Class
subclass of: GO_0036213
subclass of: part-of-parent-44837
IAO_0000115: The process of an actomyosin ring getting smaller in diameter, in the context of cytokinesis that takes place as part of a cell cycle.
has exact synonym: actomyosin contractile ring constriction
has exact synonym: contractile ring contraction involved in cell cycle cytokinesis
has exact synonym: cytokinesis, actomyosin ring contraction
has related synonym: cytokinesis, contractile ring contraction

division septum assembly
type: Class
subclass of: GO_0090529
subclass of: part-of-parent-910
IAO_0000115: The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material.
has related synonym: division septum assembly involved in cell cycle cytokinesis
has related synonym: division septum assembly involved in cell cycle cytokinesis involved in mitotic cell cycle
has exact synonym: division septum formation
has related synonym: division septum formation involved in cell cycle cytokinesis
has related synonym: division septum formation involved in cell cycle cytokinesis involved in mitotic cell cycle
has related synonym: division septum formation involved in mitotic cell cycle
has exact synonym: formation of division septum
has related synonym: formation of division septum involved in mitotic cell cycle
has related synonym: mitotic division septum assembly
has related synonym: septation
has related synonym: septin assembly and septum biosynthesis
has related synonym: septin assembly and septum biosynthesis involved in mitotic cell cycle
has related synonym: septin assembly and septum formation
has related synonym: septin assembly and septum formation involved in mitotic cell cycle
replaces: GO_0071937
replaces: GO_1902411

division septum site selection
type: Class
subclass of: GO_0032506
subclass of: part-of-parent-917
IAO_0000115: The process of marking the site where a division septum will form.
has exact synonym: selection of site for barrier cell septum biosynthesis
has exact synonym: selection of site for barrier cell septum formation
has exact synonym: selection of site for division septum formation
has related synonym: septin assembly and septum biosynthesis
has related synonym: septin assembly and septum formation
has exact synonym: septum positioning

cell plate assembly
type: Class
subclass of: GO_0022402
subclass of: GO_0022607
subclass of: part-of-parent-911
IAO_0000115: The process of assembly, maturation, and growth of the cell plate to the cell periphery in cells that divide by cell plate formation; often involves deposition of cell wall material in and around the phragmoplast.
has related synonym: cell plate formation

septum digestion after cytokinesis
type: Class
subclass of: GO_0009987
subclass of: part-of-parent-51301
IAO_0000115: The process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis.
has related synonym: cell separation after cytokinesis
has exact synonym: cell separation following cytokinesis
has related synonym: cytokinetic cell separation
has related synonym: daughter cell separation
has related synonym: mitotic cytokinetic cell separation
replaces: GO_1902409
replaces: GO_2000695

septin ring assembly
type: Class
subclass of: GO_0031106
subclass of: GO_0065003
subclass of: GO_0140694
IAO_0000115: The aggregation, arrangement and bonding together of septins and associated proteins to form an organized structure resembling a ring at the cell cortex.
has related synonym: septin assembly and septum biosynthesis
has related synonym: septin assembly and septum formation

spindle pole
type: Class
subclass of: GO_0110165
subclass of: part-of-parent-5819
IAO_0000115: Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.
replaces: GO_0030615

equatorial microtubule organizing center
type: Class
subclass of: GO_0005815
subclass of: part-of-parent-32153
IAO_0000115: A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis.
has exact synonym: EMTOC
has exact synonym: equatorial microtubule organising centre

gamma-tubulin complex
type: Class
subclass of: GO_0032991
subclass of: part-of-parent-5815
IAO_0000115: A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species.

gamma-tubulin large complex
type: Class
subclass of: gamma-tubulin complex
IAO_0000115: A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes. An example of this structure is found in Schizosaccharomyces pombe.
has related synonym: gamma-tubulin large complex, centrosomal
has related synonym: gamma-tubulin large complex, eMTOC
has related synonym: gamma-tubulin large complex, equatorial microtubule organizing center
has related synonym: gamma-tubulin large complex, equatorial microtubule organizing centre
has related synonym: gamma-tubulin large complex, iMTOC
has related synonym: gamma-tubulin large complex, interphase microtubule organizing center
has related synonym: gamma-tubulin large complex, interphase microtubule organizing centre
has related synonym: gamma-tubulin large complex, mitotic spindle pole body
has related synonym: gamma-tubulin large complex, spindle pole body
has related synonym: gamma-tubulin ring complex
has related synonym: gamma-tubulin ring complex, centrosomal
replaces: GO_0000924
replaces: GO_0000925
replaces: GO_0000926
replaces: GO_0000929
replaces: GO_0008274
replaces: GO_0055031
replaces: GO_0055032
replaces: GO_0055033
replaces: GO_0061494

P-body
type: Class
subclass of: GO_0036464
IAO_0000115: A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
has related synonym: cytoplasmic foci
has exact synonym: cytoplasmic mRNA processing body
has exact synonym: P body

adventitious septum
type: Class
subclass of: GO_0030428
IAO_0000115: A cell septum whose formation is independent of nuclear division.

porous cell septum
type: Class
subclass of: GO_0030428
IAO_0000115: A septum or cross wall which does not entirely span the space between two portions of cell wall and may contain a specialized central pore structure. A porous septum allows the movement of organelles and/or cytoplasm between compartments.
has related synonym: porous septum

division septum
type: Class
subclass of: GO_0030428
subclass of: part-of-parent-32153
IAO_0000115: A cell septum which forms as part of the division site and functions in the compartmentalization of a cell into two daughter cells at division. A division septum spans a cell and does not allow exchange of organelles or cytoplasm between compartments.
has related synonym: cell septum surface
has exact synonym: complete septum
has exact synonym: divison septum
has related synonym: septum surface
replaces: GO_0043187

primary cell septum
type: Class
subclass of: division septum
IAO_0000115: A cell septum that forms following nuclear division.
has related synonym: primary septum

dolipore septum
type: Class
subclass of: porous cell septum
IAO_0000115: A septum, or cross-wall, between two portions of a cell or hypha; contains a central pore around which the septum is swollen to form a barrel-shaped structure; pore is covered on each side of the septum by a septal pore cap (parenthosome).

GARP complex
type: Class
subclass of: GO_0099023
subclass of: part-of-parent-5794
subclass of: part-of-parent-31410
IAO_0000115: A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles.
has exact synonym: Golgi associated retrograde protein complex
has exact synonym: VFT tethering complex
has exact synonym: Vps fifty three tethering complex

inner kinetochore
type: Class
subclass of: GO_0032991
subclass of: part-of-parent-776
IAO_0000115: The region of a kinetochore closest to centromeric DNA; in mammals the CREST antigens (CENP proteins) are found in this layer; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome.
has exact synonym: condensed chromosome inner kinetochore
has exact synonym: condensed nuclear chromosome inner kinetochore
has related synonym: inner centromere core complex
has exact synonym: inner kinetochore of condensed chromosome
has exact synonym: inner kinetochore of condensed nuclear chromosome
has related synonym: inner kinetochore plate
replaces: GO_0000941

outer kinetochore
type: Class
subclass of: GO_0032991
subclass of: part-of-parent-776
IAO_0000115: The region of a kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.
has exact synonym: condensed chromosome outer kinetochore
has exact synonym: condensed nuclear chromosome outer kinetochore
has exact synonym: outer kinetochore of condensed chromosome
has exact synonym: outer kinetochore of condensed nuclear chromosome
has related synonym: outer kinetochore plate
replaces: GO_0000942

retrotransposon nucleocapsid
type: Class
subclass of: GO_0110165
subclass of: part-of-parent-5634
IAO_0000115: A complex of the retrotransposon RNA genome, reverse transcriptase, integrase, and associated molecules required for reproduction and integration of the retrotransposon into the host genome; the main structural molecule of the nucleocapsid is often a gag protein homolog.
has exact synonym: Virus-like particle
has exact synonym: VLP

amino acid catabolic process to alcohol via Ehrlich pathway
type: Class
subclass of: amino acid catabolic process via Ehrlich pathway
subclass of: GO_0046165
IAO_0000115: The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.

amino acid catabolic process to carboxylic acid via Ehrlich pathway
type: Class
subclass of: amino acid catabolic process via Ehrlich pathway
subclass of: GO_0046394
IAO_0000115: The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.

aromatic amino acid family catabolic process to alcohol via Ehrlich pathway
type: Class
subclass of: amino acid catabolic process to alcohol via Ehrlich pathway
subclass of: GO_0009074
IAO_0000115: The chemical reactions and pathways involving the catabolism of aromatic amino acids to produce aromatic alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanol, 4-hydroxyphenylethanol, or tryptophol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.

branched-chain amino acid catabolic process to alcohol via Ehrlich pathway
type: Class
subclass of: amino acid catabolic process to alcohol via Ehrlich pathway
subclass of: GO_0009083
IAO_0000115: The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanol, 2-methylbutanol, or 2-methylpropanol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.
has exact synonym: branched chain family amino acid catabolic process to alcohol via Ehrlich pathway

methionine catabolic process to 3-methylthiopropanol
type: Class
subclass of: amino acid catabolic process to alcohol via Ehrlich pathway
subclass of: GO_0009087
subclass of: GO_0044272
IAO_0000115: The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanol is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.

aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway
type: Class
subclass of: amino acid catabolic process to carboxylic acid via Ehrlich pathway
subclass of: GO_0009074
IAO_0000115: The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanoate, 4-hydroxyphenylethanoate, or 2-(Indol-3-yl)-ethanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.

branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway
type: Class
subclass of: amino acid catabolic process to carboxylic acid via Ehrlich pathway
subclass of: GO_0009083
IAO_0000115: The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanoate, 2-methylbutanoate, or 2-methylpropanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.
has exact synonym: branched chain family amino acid catabolic process to carboxylic acid via Ehrlich pathway

methionine catabolic process to 3-methylthiopropanoate
type: Class
subclass of: amino acid catabolic process to carboxylic acid via Ehrlich pathway
subclass of: GO_0006633
subclass of: GO_0009087
subclass of: GO_0044272
IAO_0000115: The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanoate is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.

amino acid catabolic process via Ehrlich pathway
type: Class
subclass of: GO_0009063
IAO_0000115: The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols or carboxylic acids containing one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives, sometimes referred to as fusel acids, may be produced instead of alcohols.

nuclear-transcribed mRNA catabolic process
type: Class
subclass of: GO_0006402
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells.
has exact synonym: nuclear mRNA breakdown
has exact synonym: nuclear mRNA catabolism
has exact synonym: nuclear mRNA degradation

mitochondrial RNA catabolic process
type: Class
subclass of: mitochondrial RNA metabolic process
subclass of: GO_0006401
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of RNA transcribed from the mitochondrial genome and occurring in the mitochondrion.

mitochondrial mRNA catabolic process
type: Class
subclass of: mitochondrial RNA catabolic process
subclass of: GO_0006402
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion.

mitochondrial RNA metabolic process
type: Class
subclass of: GO_0016070
IAO_0000115: The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion.

regulation of mitochondrial RNA catabolic process
type: Class
subclass of: GO_0031329
subclass of: GO_0051252
IAO_0000115: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome.

negative regulation of mitochondrial RNA catabolic process
type: Class
subclass of: regulation of mitochondrial RNA catabolic process
subclass of: GO_1902369
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome.

positive regulation of mitochondrial RNA catabolic process
type: Class
subclass of: regulation of mitochondrial RNA catabolic process
subclass of: GO_0031331
subclass of: GO_0051254
IAO_0000115: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome.

mitochondrial RNA processing
type: Class
subclass of: mitochondrial RNA metabolic process
subclass of: GO_0006396
subclass of: GO_0140053
IAO_0000115: The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion.

mitochondrial RNA 5'-end processing
type: Class
subclass of: mitochondrial RNA processing
subclass of: RNA 5'-end processing
IAO_0000115: Any process involved in forming the mature 5' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion.
has related synonym: mitochondrial RNA 5' end processing

mitochondrial RNA 3'-end processing
type: Class
subclass of: mitochondrial RNA processing
subclass of: GO_0031123
IAO_0000115: Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion.
has related synonym: mitochondrial RNA 3' end processing

RNA 5'-end processing
type: Class
subclass of: GO_0006396
IAO_0000115: Any process involved in forming the mature 5' end of an RNA molecule.
has exact synonym: RNA 5' end processing

rRNA 5'-end processing
type: Class
subclass of: GO_0006364
subclass of: GO_0034471
IAO_0000115: Any process involved in forming the mature 5' end of an rRNA molecule.
has exact synonym: rRNA 5' end processing

tRNA exon ligation
type: Class
subclass of: RNA exon ligation
subclass of: part-of-parent-6388
IAO_0000115: An RNA exon ligation process that rejoins two exons of a pre-tRNA which has had the intron removed.

tRNA exon ligation utilizing ATP as source of linkage phosphate
type: Class
subclass of: tRNA exon ligation
IAO_0000115: A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous ATP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in vertebrate species.

tRNA exon ligation utilizing GTP as source of linkage phosphate
type: Class
subclass of: tRNA exon ligation
IAO_0000115: A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous GTP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in the yeast Saccharomyces cerevisiae where the ligation reaction also produces a 2'-phosphate at the splice junction which is subsequently removed as part of the ligation process.

tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate
type: Class
subclass of: tRNA exon ligation
IAO_0000115: A tRNA exon ligation process in which the splice junction phosphate is derived from the 2',3' cyclic phosphate at the 3'-end of the 5'-exon. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in wheat, Chlamydomonas, and vertebrate species including humans.

transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
type: Class
subclass of: GO_0051276
IAO_0000115: The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery. In S. cerevisiae, this process involves cis-acting DNA sequences such as the TATA box and upstream activating sequence (UAS) elements, trans-acting transcriptional activators, and also the 3'-UTR of the transcript.

post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
type: Class
subclass of: transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
IAO_0000115: The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery even after transcription has been repressed.
has exact synonym: posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery

Prp19 complex
type: Class
subclass of: GO_0032991
IAO_0000115: A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p.
has related synonym: nineteen complex
has related synonym: NTC
has related synonym: Prp19/CDC5 complex

transcription cis-regulatory region binding
type: Class
subclass of: transcription regulatory region nucleic acid binding
subclass of: GO_1990837
IAO_0000115: Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
has related synonym: bacterial-type RNA polymerase regulatory region DNA binding
has related synonym: bacterial-type RNA polymerase transcription regulatory region sequence-specific DNA binding
has related synonym: eubacterial-type RNA polymerase regulatory region DNA binding
has related synonym: eubacterial-type RNA polymerase regulatory region sequence-specific DNA binding
has related synonym: regulatory region DNA binding
has related synonym: transcription regulatory region DNA binding
has exact synonym: transcription regulatory region sequence-specific DNA binding
replaces: GO_0000975
replaces: GO_0000984
replaces: GO_0001017
replaces: GO_0044212

RNA polymerase II transcription regulatory region sequence-specific DNA binding
type: Class
subclass of: transcription cis-regulatory region binding
IAO_0000115: Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
has related synonym: RNA polymerase II regulatory region DNA binding
replaces: GO_0001012

RNA polymerase II cis-regulatory region sequence-specific DNA binding
type: Class
subclass of: RNA polymerase II transcription regulatory region sequence-specific DNA binding
subclass of: cis-regulatory region sequence-specific DNA binding
IAO_0000115: Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
has related synonym: RNA polymerase II core promoter proximal region sequence-specific DNA binding
has related synonym: RNA polymerase II distal enhancer sequence-specific DNA binding
has related synonym: RNA polymerase II promoter proximal region sequence-specific DNA binding
has related synonym: RNA polymerase II proximal promoter sequence-specific DNA binding
has related synonym: RNA polymerase II upstream activating sequence (UAS) sequence-specific DNA binding
replaces: GO_0000980

RNA polymerase II core promoter sequence-specific DNA binding
type: Class
subclass of: RNA polymerase II transcription regulatory region sequence-specific DNA binding
subclass of: core promoter sequence-specific DNA binding
IAO_0000115: Binding to a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene.

DNA-binding transcription factor activity, RNA polymerase II-specific
type: Class
subclass of: DNA-binding transcription factor activity
subclass of: part-of-parent-6357
IAO_0000115: A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
has related synonym: copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity
has related synonym: metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity
has related synonym: metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity
has related synonym: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
has related synonym: RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
has related synonym: RNA polymerase II transcription factor activity, copper ion regulated core promoter proximal region sequence-specific binding
has related synonym: RNA polymerase II transcription factor activity, copper ion regulated proximal promoter sequence-specific DNA binding
has related synonym: RNA polymerase II transcription factor activity, metal ion regulated core promoter proximal region sequence-specific binding
has related synonym: RNA polymerase II transcription factor activity, metal ion regulated proximal promoter sequence-specific DNA binding
has related synonym: RNA polymerase II transcription factor activity, metal ion regulated sequence-specific DNA binding
has exact synonym: RNA polymerase II transcription factor activity, sequence-specific DNA binding
has exact synonym: RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding
has related synonym: RNA polymerase II transcription factor activity, zinc ion regulated core promoter proximal region sequence-specific DNA binding
has related synonym: RNA polymerase II transcription factor activity, zinc ion regulated proximal promoter sequence-specific DNA binding
has related synonym: sequence-specific distal enhancer binding RNA polymerase II transcription factor activity
has exact synonym: sequence-specific DNA binding RNA polymerase II transcription factor activity
has related synonym: sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity
has related synonym: transcription factor
has related synonym: transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
has related synonym: transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
has related synonym: transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
has related synonym: zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity
replaces: GO_0000982
replaces: GO_0001133
replaces: GO_0001200
replaces: GO_0001201
replaces: GO_0001202
replaces: GO_0001203
replaces: GO_0003705

cis-regulatory region sequence-specific DNA binding
type: Class
subclass of: transcription cis-regulatory region binding
IAO_0000115: Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. The proximal promoter is in cis with and relatively close to the core promoter.
has related synonym: bacterial-type cis-regulatory region sequence-specific DNA binding
has related synonym: bacterial-type proximal promoter sequence-specific DNA binding
has related synonym: bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding
has related synonym: bacterial-type RNA polymerase enhancer sequence-specific DNA binding
has related synonym: bacterial-type RNA polymerase upstream activating sequence (UAS) sequence-specific DNA binding
has related synonym: cis-regulatory region binding
has related synonym: core promoter proximal region DNA binding
has related synonym: core promoter proximal region sequence-specific DNA binding
has related synonym: enhancer binding
has related synonym: enhancer sequence-specific DNA binding
has related synonym: eubacterial-type RNA polymerase regulatory transcription factor sequence-specific DNA binding
has related synonym: promoter proximal region sequence-specific DNA binding
has related synonym: proximal promoter sequence-specific DNA binding
replaces: GO_0000986
replaces: GO_0001150
replaces: GO_0001158
replaces: GO_0001159
replaces: GO_0035326

obsolete transcription factor activity, protein binding
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to a protein or protein complex, to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.

obsolete transcription factor activity, transcription factor binding
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to a specific transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.

obsolete transcription factor activity, core RNA polymerase binding
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to an RNA polymerase in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.

obsolete transcription factor activity, core RNA polymerase II binding
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.

RNA polymerase III cis-regulatory region sequence-specific DNA binding
type: Class
subclass of: cis-regulatory region sequence-specific DNA binding
subclass of: RNA polymerase III transcription regulatory region sequence-specific DNA binding
IAO_0000115: Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase III. The transcribed region might be contain a single gene or a cistron containing multiple genes.

RNA polymerase II complex binding
type: Class
subclass of: basal RNA polymerase II transcription machinery binding
subclass of: GO_0043175
IAO_0000115: Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits.
has exact synonym: RNAP II core binding
has exact synonym: RNA polymerase II core binding

RNA polymerase III core binding
type: Class
subclass of: GO_0043175
IAO_0000115: Binding to an RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits.

RNA polymerase III general transcription initiation factor activity
type: Class
subclass of: GO_0140223
subclass of: part-of-parent-6383
IAO_0000115: A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC. RNA polymerase III transcribes genes encoding short RNAs, including tRNAs, 5S rRNA, U6 snRNA, the short ncRNA component of RNases P, the mitochondrial RNA processing (MRP) RNA, the signal recognition particle SRP RNA, and in higher eukaryotes a number of micro and other small RNAs, though there is some variability across species as to whether a given small noncoding RNA is transcribed by RNA polymerase II or RNA polymerase III.
has related synonym: core RNA polymerase III binding transcription factor activity
has exact synonym: RNA polymerase III general initiation factor activity
has related synonym: RNA polymerase III transcription factor activity, sequence-specific DNA binding
has related synonym: sequence-specific DNA binding RNA polymerase III transcription factor activity
has related synonym: transcription factor activity, core RNA polymerase III binding
replaces: GO_0001034

bacterial-type RNA polymerase core enzyme binding
type: Class
subclass of: GO_0043175
IAO_0000115: Binding to a bacterial-type RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one omega subunit.
has exact synonym: eubacterial-type RNA polymerase core enzyme binding

mitochondrial single-subunit type RNA polymerase binding
type: Class
subclass of: single-subunit type RNA polymerase binding
IAO_0000115: Binding to a single subunit mitochondrial RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6.

RNA polymerase III type 1 promoter sequence-specific DNA binding
type: Class
subclass of: RNA polymerase III cis-regulatory region sequence-specific DNA binding
subclass of: GO_0080084
IAO_0000115: Binding to a sequence of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition.
has related synonym: RNA polymerase III type 1 promoter DNA binding
replaces: GO_0001030

RNA polymerase III type 2 promoter sequence-specific DNA binding
type: Class
subclass of: RNA polymerase III cis-regulatory region sequence-specific DNA binding
IAO_0000115: Binding to a sequence of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs.
has related synonym: RNA polymerase III type 2 promoter DNA binding
replaces: GO_0001031

obsolete RNA polymerase III transcription regulator recruiting activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Initiating the assembly of the RNA polymerase III pre-initiation complex by binding to a control sequence in the intragenic region. This allows to recruit TFIIIB to the DNA at a site centered approximately 26 base pairs upstream of the start site of transcription. For tRNA genes, TFIIIC first associates with DNA, and then recruits TFIIIB. For 5S rRNA genes, TFIIIA binds to DNA first, followed by TFIIIC, which then recruits TFIIIB.
replaces: GO_0001005
replaces: GO_0001008
replaces: GO_0001033
replaces: GO_0001038
replaces: GO_0001157

RNA polymerase III type 3 promoter sequence-specific DNA binding
type: Class
subclass of: RNA polymerase III cis-regulatory region sequence-specific DNA binding
IAO_0000115: Binding to a sequence of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III (Pol III). A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae.
has related synonym: RNA polymerase III type 3 promoter DNA binding
replaces: GO_0001032

obsolete transcription factor activity, RNA polymerase III transcription factor binding
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to an RNA polymerase III transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.

RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity
type: Class
subclass of: GO_0030674
IAO_0000115: The function of binding to a specific DNA sequence and recruiting another transcription factor to the DNA in order to modulate transcription. The recruited factor may bind DNA directly, or may be colocalized via protein-protein interactions.
has exact synonym: sequence-specific DNA binding transcription factor recruiting transcription factor activity
has exact synonym: transcription factor activity, sequence-specific DNA binding transcription factor recruiting
has related synonym: transcription factor activity, sequence-specific DNA-binding transcription factor recruiting

obsolete transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to a specific DNA sequence and recruiting RNA polymerase to the DNA in order to form the preinitiation complex (PIC).

snoRNA transcription by RNA polymerase III
type: Class
subclass of: GO_0006383
subclass of: GO_0009302
IAO_0000115: The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase III, originating at a type 2 RNA polymerase III promoter.
has related synonym: snoRNA transcription from a type 2 RNA polymerase III promoter

snoRNA transcription by RNA polymerase II
type: Class
subclass of: GO_0006366
subclass of: GO_0009302
IAO_0000115: The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter.
has exact synonym: snoRNA transcription from an RNA polymerase II promoter

RNA polymerase III transcription regulatory region sequence-specific DNA binding
type: Class
subclass of: transcription cis-regulatory region binding
IAO_0000115: Binding to a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
has related synonym: RNA polymerase III regulatory region DNA binding

mitochondrial promoter sequence-specific DNA binding
type: Class
subclass of: transcription cis-regulatory region binding
IAO_0000115: Binding to a DNA region that controls the transcription of the mitochondrial DNA.
has related synonym: HSPas binding
has related synonym: HSP coding strand binding
has related synonym: HSP non-coding strand binding
has related synonym: HSPs binding
has related synonym: LSPas binding
has related synonym: LSP coding strand binding
has related synonym: LSP non-coding strand binding
has related synonym: LSPs binding
has related synonym: mitochondrial heavy strand promoter anti-sense binding
has related synonym: mitochondrial heavy strand promoter sense binding
has related synonym: mitochondrial light strand promoter anti-sense binding
has related synonym: mitochondrial light strand promoter sense binding
has related synonym: mitochondrial proximal promoter sequence-specific DNA binding
has related synonym: mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding
has related synonym: mitochondrial RNA polymerase core promoter sequence-specific DNA binding
has related synonym: mitochondrial RNA polymerase regulatory region DNA binding
has related synonym: mitochondrial RNA polymerase regulatory region sequence-specific DNA binding
replaces: GO_0000997
replaces: GO_0001044
replaces: GO_0001045
replaces: GO_0070361
replaces: GO_0070362
replaces: GO_0070363
replaces: GO_0070364

plastid promoter transcription regulatory region sequence-specific DNA binding
type: Class
subclass of: transcription cis-regulatory region binding
IAO_0000115: Binding to a DNA region that controls transcription by a plastid RNA polymerase. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.

RNA polymerase III general transcription initiation factor binding
type: Class
subclass of: GO_0140296
IAO_0000115: Binding to an RNA polymerase III transcription factor, a protein required to initiate or regulate transcription by RNA polymerase III.
has related synonym: RNA polymerase III transcription factor binding

obsolete TFIIIB-type transcription factor activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way, Once recruited to an RNA polymerase III promoter by one or more other transcription factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex.

obsolete RNA polymerase III type 1 promoter TFIIIB-type transcription factor activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 1 promoter by TFIIIA-type and TFIIIC-type factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex.

obsolete RNA polymerase III type 2 promoter TFIIIB-type transcription factor activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 2 promoter by a TFIIIC-type factor, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex.

obsolete RNA polymerase III type 3 promoter TFIIIB-type transcription factor activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 3 promoter by SNAP-type and TFIIIC-type factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex.

RNA polymerase III hybrid type promoter sequence-specific DNA binding
type: Class
subclass of: RNA polymerase III cis-regulatory region sequence-specific DNA binding
IAO_0000115: Binding to a sequence of DNA that is a part of a hybrid type promoter that controls transcription by RNA polymerase III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene.
has related synonym: RNA polymerase III hybrid type promoter DNA binding
replaces: GO_0001037

obsolete RNA polymerase III hybrid type promoter TFIIIB-type transcription factor activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III hybrid type promoter, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex.

RNA polymerase I core binding
type: Class
subclass of: GO_0043175
IAO_0000115: Binding to a RNA polymerase I core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits.

core promoter sequence-specific DNA binding
type: Class
subclass of: transcription cis-regulatory region binding
IAO_0000115: Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.
has related synonym: bacterial-type RNA polymerase core promoter sequence-specific DNA binding
has related synonym: core promoter binding
has related synonym: eubacterial-type RNA polymerase core promoter sequence-specific DNA binding
replaces: GO_0000985
replaces: GO_0001047

RNA polymerase IV core binding
type: Class
subclass of: GO_0043175
IAO_0000115: Binding to RNA polymerase IV core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in siRNA production.

RNA polymerase V core binding
type: Class
subclass of: GO_0043175
IAO_0000115: Binding to RNA polymerase V core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in production of noncoding transcripts at target loci for silencing.

single-subunit type RNA polymerase binding
type: Class
subclass of: GO_0070063
IAO_0000115: Binding to a single subunit RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6.
has exact synonym: SP6-type RNA polymerase binding
has exact synonym: T3/T7 type RNA polymerase binding
has exact synonym: T3-type RNA polymerase binding
has exact synonym: T7-type RNA polymerase binding

plastid single-subunit type RNA polymerase binding
type: Class
subclass of: single-subunit type RNA polymerase binding
IAO_0000115: Binding to a single subunit plastid RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6.

plastid PEP RNA polymerase core enzyme binding
type: Class
subclass of: bacterial-type RNA polymerase core enzyme binding
IAO_0000115: Binding to a bacterial-type plastid PEP RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one double prime subunit.

RNA polymerase I activity
type: Class
subclass of: DNA-directed 5'-3' RNA polymerase activity
subclass of: part-of-parent-6360
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
has exact synonym: DNA-directed RNA polymerase activity involved in transcription from RNA polymerase I promoter

RNA polymerase II activity
type: Class
subclass of: DNA-directed 5'-3' RNA polymerase activity
subclass of: part-of-parent-6366
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
has exact synonym: DNA-directed RNA polymerase activity involved in transcription from RNA polymerase II promoter

RNA polymerase III activity
type: Class
subclass of: DNA-directed 5'-3' RNA polymerase activity
subclass of: part-of-parent-6383
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
has exact synonym: DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter

RNA polymerase IV activity
type: Class
subclass of: DNA-directed 5'-3' RNA polymerase activity
subclass of: part-of-parent-1059
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase IV specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
has exact synonym: DNA-directed RNA polymerase activity involved in transcription from RNA polymerase IV promoter

RNA polymerase V activity
type: Class
subclass of: DNA-directed 5'-3' RNA polymerase activity
subclass of: part-of-parent-1060
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase V specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
has exact synonym: DNA-directed RNA polymerase activity involved in transcription from RNA polymerase V promoter

transcription by RNA polymerase IV
type: Class
subclass of: GO_0006351
IAO_0000115: The synthesis of RNA from a DNA template by RNA polymerase IV, originating at a Pol IV-specific promoter.
has exact synonym: transcription from RNA pol IV promoter
has exact synonym: transcription from RNA polymerase IV promoter

transcription by RNA polymerase V
type: Class
subclass of: GO_0006351
IAO_0000115: The synthesis of RNA from a DNA template by RNA polymerase V, originating at a Pol V-specific promoter.
has exact synonym: transcription from RNA pol V promoter
has exact synonym: transcription from RNA polymerase V promoter

obsolete bacterial-type RNA polymerase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a bacterial-type specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.

obsolete plastid PEP-A RNA polymerase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a plastid PEP-A RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.

obsolete plastid PEP-B RNA polymerase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a plastid PEP-B RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.

single subunit type RNA polymerase activity
type: Class
subclass of: DNA-directed 5'-3' RNA polymerase activity
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
has exact synonym: T3/T7 type RNA polymerase activity

mitochondrial single subunit type RNA polymerase activity
type: Class
subclass of: single subunit type RNA polymerase activity
subclass of: part-of-parent-6390
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type mitochondrial RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.

plastid single subunit type RNA polymerase activity
type: Class
subclass of: single subunit type RNA polymerase activity
subclass of: part-of-parent-42793
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single subunit type plastid RNA polymerase specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.

transcription regulatory region nucleic acid binding
type: Class
subclass of: nucleic acid binding
IAO_0000115: Binding to a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair.
has related synonym: regulatory region nucleic acid binding

transcription regulatory region RNA binding
type: Class
subclass of: regulatory region RNA binding
IAO_0000115: Binding to a RNA region within the transcript that regulates the transcription of a gene, cistron, or operon.

regulatory region RNA binding
type: Class
subclass of: transcription regulatory region nucleic acid binding
subclass of: RNA binding
IAO_0000115: Binding to a RNA region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair.

RNA-binding transcription regulator activity
type: Class
subclass of: GO_0140110
subclass of: part-of-parent-45893
IAO_0000115: A transcription regulator activity that modulates the transcription of specific gene sets via selective and non-covalent binding to a specific RNA sequence. This function is known to occur in phages and viruses, for example the lambda N and the HIV tat proteins are necessary to allow RNA polymerase to read through terminator sequences.
has related synonym: RNA binding transcription factor activity
has exact synonym: RNA binding transcription regulator activity

transcription antitermination factor activity, RNA binding
type: Class
subclass of: GO_0140110
subclass of: part-of-parent-31564
IAO_0000115: Binds to RNA, typically within the nascent RNA transcript, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind the nascent RNA include the lambda N protein and the HIV-1 tat protein.
has exact synonym: RNA binding transcription antitermination factor activity

transcription antitermination factor activity, DNA binding
type: Class
subclass of: GO_0140110
subclass of: part-of-parent-31564
IAO_0000115: Binds to DNA, typically within region of the promoter and transcribed region, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind DNA include the lambda Q protein.
has exact synonym: DNA binding transcription antitermination factor activity

obsolete transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding involved in preinitiation complex assembly
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to promote assembly of the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase II promoter.

obsolete transcription factor activity, RNA polymerase II transcription factor binding
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.

nitrogen catabolite regulation of transcription from RNA polymerase II promoter
type: Class
subclass of: GO_0006357
subclass of: GO_0090293
IAO_0000115: A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources.
has exact synonym: regulation of transcription from RNA polymerase II promoter by nitrogen catabolites

nitrogen catabolite activation of transcription from RNA polymerase II promoter
type: Class
subclass of: nitrogen catabolite regulation of transcription from RNA polymerase II promoter
subclass of: GO_0090294
IAO_0000115: A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources.
has exact synonym: positive regulation of transcription from RNA polymerase II promoter by nitrogen catabolites

nitrogen catabolite repression of transcription from RNA polymerase II promoter
type: Class
subclass of: nitrogen catabolite regulation of transcription from RNA polymerase II promoter
subclass of: GO_0090295
IAO_0000115: A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources.
has exact synonym: negative regulation of transcription from RNA polymerase II promoter by nitrogen catabolites

obsolete transcription factor activity, RNA polymerase I transcription factor binding
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to an RNA polymerase I transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.

obsolete transcription factor activity, RNA polymerase II basal transcription factor binding
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to a basal RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.

obsolete transcription factor activity, TFIID-class binding
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to a basal RNA polymerase II transcription factor of the TFIID class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.

obsolete transcription factor activity, TFIIA-class binding
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to a basal RNA polymerase II transcription factor of the TFIIA class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.

obsolete transcription factor activity, TFIIB-class binding
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to a basal RNA polymerase II transcription factor of the TFIIB class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.

obsolete transcription factor activity, TFIIE-class binding
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to a basal RNA polymerase II transcription factor of the TFIIE class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.

obsolete transcription factor activity, TFIIF-class transcription factor binding
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to a basal RNA polymerase II transcription factor of the TFIIF class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.

obsolete transcription factor activity, TFIIH-class binding
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to a basal RNA polymerase II transcription factor of the TFIIH class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.

RNA polymerase II general transcription initiation factor binding
type: Class
subclass of: basal RNA polymerase II transcription machinery binding
subclass of: GO_0140296
IAO_0000115: Binding to a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.
has exact synonym: RNA polymerase II basal transcription factor binding

TFIIA-class transcription factor complex binding
type: Class
subclass of: RNA polymerase II general transcription initiation factor binding
subclass of: GO_0044877
IAO_0000115: Binding to a general RNA polymerase II transcription factor belonging to the TFIIA complex, one of the complexes involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.
has exact synonym: TFIIA-class transcription factor binding

TFIIB-class transcription factor binding
type: Class
subclass of: RNA polymerase II general transcription initiation factor binding
IAO_0000115: Binding to a general RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.

TFIID-class transcription factor complex binding
type: Class
subclass of: RNA polymerase II general transcription initiation factor binding
subclass of: GO_0044877
IAO_0000115: Binding to a general RNA polymerase II transcription factor belonging to the TFIID complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.
has exact synonym: TFIID-class transcription factor binding

TFIIE-class transcription factor complex binding
type: Class
subclass of: RNA polymerase II general transcription initiation factor binding
subclass of: GO_0044877
IAO_0000115: Binding to a general RNA polymerase II transcription factor belonging to the TFIIE complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.
has exact synonym: TFIIE-class transcription factor binding

TFIIF-class transcription factor complex binding
type: Class
subclass of: RNA polymerase II general transcription initiation factor binding
subclass of: GO_0044877
IAO_0000115: Binding to a general RNA polymerase II transcription factor belonging to the TFIIF complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.
has exact synonym: TFIIF-class transcription factor binding

TFIIH-class transcription factor complex binding
type: Class
subclass of: RNA polymerase II general transcription initiation factor binding
subclass of: GO_0044877
IAO_0000115: Binding to a general RNA polymerase II transcription factor belonging to the TFIIH complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.
has exact synonym: TFIIH-class transcription factor binding

basal transcription machinery binding
type: Class
subclass of: GO_0005515
IAO_0000115: Binding to a component of the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase.

basal RNA polymerase II transcription machinery binding
type: Class
subclass of: basal transcription machinery binding
IAO_0000115: Binding to a component of the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase.
has exact synonym: basal RNAP II transcription machinery binding

negative regulation of exit from mitosis
type: Class
subclass of: GO_0007096
subclass of: GO_1901991
IAO_0000115: Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity).
has exact synonym: downregulation of exit from mitosis
has exact synonym: down regulation of exit from mitosis
has exact synonym: down-regulation of exit from mitosis
has related synonym: inhibition of exit from mitosis

response to acid chemical
type: Class
subclass of: GO_0042221
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.
has related synonym: response to acid
has related synonym: response to acid anion
has related synonym: response to oxoanion

bacterial-type RNA polymerase holo enzyme binding
type: Class
subclass of: basal transcription machinery binding
IAO_0000115: Binding to a component of the basal transcription machinery which is composed of a bacterial-type RNA polymerase core enzyme and a sigma factor, the minimal set of factors required for formation of the preinitiation complex (PIC) by a bacterial-type RNA polymerase.
has exact synonym: basal bacterial-type RNA polymerase transcription machinery binding

promoter clearance during DNA-templated transcription
type: Class
subclass of: GO_0032774
subclass of: part-of-parent-6351
IAO_0000115: Any process involved in the transition from the initiation to the elongation phases of transcription by a DNA-dependent RNA polymerase, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors.
has exact synonym: promoter clearance during DNA-dependent transcription
has related synonym: promoter clearance from bacterial-type RNA polymerase promoter
has related synonym: promoter escape
replaces: GO_0001122

RNA polymerase III promoter clearance
type: Class
subclass of: promoter clearance during DNA-templated transcription
subclass of: part-of-parent-6383
IAO_0000115: A process that mediates the transition from the initiation to the elongation phases of transcription by RNA polymerase III, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase.
has exact synonym: promoter clearance from RNA polymerase III promoter

RNA polymerase II promoter clearance
type: Class
subclass of: promoter clearance during DNA-templated transcription
subclass of: part-of-parent-6366
IAO_0000115: A process that mediates the transition from the initiation to the elongation phases of transcription by RNA polymerase II, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors.
has exact synonym: promoter clearance from RNA polymerase II promoter
has exact synonym: promoter escape from RNA polymerase II promoter
has exact synonym: promoter-paused RNA polymerase II release

DNA-templated transcription open complex formation
type: Class
subclass of: protein-DNA complex remodeling
subclass of: part-of-parent-6352
IAO_0000115: Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.
has exact synonym: DNA-dependent transcriptional open complex formation
has exact synonym: DNA-templated transcriptional open complex formation
has related synonym: promoter melting
has related synonym: transcriptional open complex formation at bacterial-type RNA polymerase promoter
has related synonym: transcription open complex formation at bacterial-type RNA polymerase promoter
replaces: GO_0001127

transcription open complex formation at RNA polymerase II promoter
type: Class
subclass of: DNA-templated transcription open complex formation
subclass of: part-of-parent-6367
IAO_0000115: Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.
has exact synonym: RNA polymerase II promoter melting
has exact synonym: transcriptional open complex formation at RNA polymerase II promoter

protein-DNA-RNA complex
type: Class
subclass of: GO_0032991
IAO_0000115: A macromolecular complex containing protein, DNA, and RNA molecules.

protein-DNA-RNA complex subunit organization
type: Class
subclass of: GO_0043933
IAO_0000115: Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA-RNA complex.
has exact synonym: protein-DNA-RNA complex subunit organisation

protein-DNA-RNA complex assembly
type: Class
subclass of: protein-DNA-RNA complex subunit organization
subclass of: GO_0065003
IAO_0000115: The aggregation, arrangement and bonding together of proteins, DNA, and RNA molecules to form a protein-DNA-RNA complex.

protein-DNA-RNA complex disassembly
type: Class
subclass of: protein-DNA-RNA complex subunit organization
subclass of: GO_0032984
IAO_0000115: The disaggregation of a protein-DNA-RNA complex into its constituent components.

transcription ternary complex disassembly
type: Class
subclass of: protein-DNA-RNA complex disassembly
subclass of: part-of-parent-6353
IAO_0000115: The disaggregation of a transcription ternary complex, composed of RNA polymerase, template DNA, and an RNA transcript, into its constituent components.
has exact synonym: transcription protein-DNA-RNA complex disassembly

protein-DNA-RNA complex remodeling
type: Class
subclass of: protein-DNA-RNA complex subunit organization
subclass of: GO_0034367
IAO_0000115: The acquisition, loss, or modification of macromolecules within a protein-DNA-RNA complex, resulting in the alteration of an existing complex.

protein-DNA complex remodeling
type: Class
subclass of: GO_0034367
subclass of: GO_0071824
IAO_0000115: The acquisition, loss, or modification of macromolecules within a protein-DNA complex, resulting in the alteration of an existing complex.

obsolete RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or stability of the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC). Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery.

obsolete RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), to facilitate the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.

obsolete RNA polymerase II transcription factor activity, TBP-class protein binding
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.

obsolete transcription regulator recruiting activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The function of binding to an RNA polymerase (RNAP) transcription regulator and recruiting it to the general transcription machinery complex in order to modulate transcription initiation.

obsolete RNA polymerase II transcription regulator recruiting activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The function of binding to an RNA polymerase II (RNAP II) transcription regulator and recruiting it to the general transcription machinery complex in order to modulate transcription initiation.
replaces: GO_0001136
replaces: GO_0001137
replaces: GO_0001138

RNA polymerase II complex recruiting activity
type: Class
subclass of: RNA polymerase II complex binding
subclass of: GO_0030674
subclass of: part-of-parent-51123
IAO_0000115: Binding to an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
has exact synonym: core RNA polymerase II recruiting transcription factor activity
has related synonym: transcription factor activity, core RNA polymerase II recruiting

transcription termination site sequence-specific DNA binding
type: Class
subclass of: transcription cis-regulatory region binding
subclass of: part-of-parent-6353
IAO_0000115: Binding to a sequence of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon.
has related synonym: bacterial-type RNA polymerase termination site sequence-specific DNA binding
has related synonym: mitochondrial RNA polymerase termination site sequence-specific DNA binding
has related synonym: mitochondrial RNA polymerase terminator site sequence-specific DNA binding transcription factor activity
has related synonym: transcription factor activity, mitochondrial RNA polymerase terminator site sequence-specific binding
has related synonym: transcription termination site DNA binding
replaces: GO_0001145
replaces: GO_0001146
replaces: GO_0001148
replaces: GO_0001160

obsolete transcription factor activity, bacterial-type RNA polymerase termination site sequence-specific binding
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to a sequence of DNA that is a termination site for bacterial-type RNA polymerase in order to promote transcription termination by bacterial-type RNA polymerase.

obsolete transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIC recruiting
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The function of binding to a specific DNA sequence motif in a type 1 RNA polymerase III (Pol III) promoter in order to recruit the transcription factor TFIIIC to the promoter.

obsolete transcription factor activity, RNA polymerase III transcription factor recruiting
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The function of binding to an RNA polymerase III (RNAP III) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP III.

TFIIIB-class transcription factor complex binding
type: Class
subclass of: RNA polymerase III general transcription initiation factor binding
IAO_0000115: Binding to a general RNA polymerase III transcription factor belonging to the TFIIB complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III.
has exact synonym: TFIIIB-class transcription factor binding

TFIIIA-class transcription factor binding
type: Class
subclass of: RNA polymerase III general transcription initiation factor binding
IAO_0000115: Binding to an RNA polymerase III transcription factor of the TFIIIA class, one of the factors involved in formation of the preinitiation complex (PIC) at RNA polymerase III promoters.

TFIIIC-class transcription factor complex binding
type: Class
subclass of: RNA polymerase III general transcription initiation factor binding
IAO_0000115: Binding to a general RNA polymerase III transcription factor belonging to the TFIIC complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III.
has exact synonym: TFIIIC-class transcription factor binding

intronic transcription regulatory region sequence-specific DNA binding
type: Class
subclass of: transcription cis-regulatory region binding
IAO_0000115: Binding to an intronic DNA sequence that regulates the transcription of the transcript it is contained within.
has related synonym: intronic transcription regulatory region DNA binding
replaces: GO_0044213

RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
type: Class
subclass of: RNA polymerase II transcription regulatory region sequence-specific DNA binding
subclass of: intronic transcription regulatory region sequence-specific DNA binding
IAO_0000115: Binding to an RNA polymerase II intronic DNA sequence that regulates the transcription of the transcript it is contained within.

RNA polymerase I transcription regulatory region sequence-specific DNA binding
type: Class
subclass of: transcription cis-regulatory region binding
IAO_0000115: Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase I.
has related synonym: RNA polymerase I regulatory region DNA binding
replaces: GO_0001013

RNA polymerase I core promoter sequence-specific DNA binding
type: Class
subclass of: core promoter sequence-specific DNA binding
subclass of: RNA polymerase I transcription regulatory region sequence-specific DNA binding
subclass of: part-of-parent-1188
IAO_0000115: Binding to a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE.
has exact synonym: RNA polymerase I CORE element sequence-specific DNA binding
has related synonym: RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity
has related synonym: transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting
replaces: GO_0001187

RNA polymerase I cis-regulatory region sequence-specific DNA binding
type: Class
subclass of: RNA polymerase I transcription regulatory region sequence-specific DNA binding
IAO_0000115: Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase I. RNA polymerase I elements are referred to either enhancers or upstream control element (UCE, or alternately referred to as the upstream element).
has related synonym: RNA polymerase I enhancer sequence-specific DNA binding
has related synonym: RNA polymerase I upstream control element sequence-specific DNA binding
has related synonym: RNA polymerase I upstream element sequence-specific DNA binding
replaces: GO_0001166

obsolete RNA polymerase I transcription factor activity, sequence-specific DNA binding
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to a specific DNA sequence in order to modulate transcription by RNA polymerase I. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.

obsolete transcription factor activity, RNA polymerase I upstream control element sequence-specific binding
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to a upstream control element (UCE, or alternately referred to as the upstream element, UE), a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase I in order to modulate transcription by RNA polymerase I.

obsolete transcription factor activity, RNA polymerase I CORE element sequence-specific binding
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to CORE element, a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery in order to modulate transcription by RNA polymerase I.

obsolete transcription factor activity, RNA polymerase I enhancer sequence-specific binding
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to a RNA polymerase I (Pol I) enhancer in order to modulate transcription by RNA polymerase I.

reverse transcription
type: Class
subclass of: GO_0006278
IAO_0000115: A DNA synthesis process that uses RNA as the initial template for synthesis of DNA, but which also includes an RNase activity to remove the RNA strand of an RNA-DNA heteroduplex produced by the RNA-dependent synthesis step and use of the initial DNA strand as a template for DNA synthesis.

RNA-templated transcription
type: Class
subclass of: GO_0097659
IAO_0000115: The synthesis of an RNA transcript from an RNA template.
has exact synonym: transcription, RNA-dependent
has exact synonym: transcription, RNA-templated

DNA-templated transcriptional start site selection
type: Class
subclass of: GO_0032774
subclass of: part-of-parent-6352
IAO_0000115: Any process involved in the selection of the specific location within the template strand of a DNA-dependent RNA polymerase promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.
has exact synonym: DNA-dependent transcriptional start site selection
has related synonym: transcriptional start site selection at bacterial-type RNA polymerase promoter
replaces: GO_0001176

transcriptional start site selection at RNA polymerase II promoter
type: Class
subclass of: DNA-templated transcriptional start site selection
subclass of: part-of-parent-6367
IAO_0000115: Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.

transcriptional start site selection at RNA polymerase III promoter
type: Class
subclass of: DNA-templated transcriptional start site selection
subclass of: part-of-parent-6384
IAO_0000115: Any process involved in the selection of the specific location within the template strand of an RNA polymerase III promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.

regulation of transcription open complex formation at RNA polymerase II promoter
type: Class
subclass of: GO_0051128
IAO_0000115: Any process that modulates the rate, frequency or extent of a process involved the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.
has exact synonym: regulation of transcriptional open complex formation at RNA polymerase II promoter

regulation of transcriptional start site selection at RNA polymerase II promoter
type: Class
subclass of: GO_0060260
IAO_0000115: Any process that modulates the rate, frequency or extent of a process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.
has exact synonym: regulation of transcription start site selection at RNA polymerase II promoter

RNA polymerase I general transcription initiation factor binding
type: Class
subclass of: GO_0140296
IAO_0000115: Binding to an RNA polymerase I transcription factor, a protein required to initiate or regulate transcription by RNA polymerase I.
has related synonym: RNA polymerase I transcription factor binding

RNA polymerase I general transcription initiation factor activity
type: Class
subclass of: GO_0140223
subclass of: part-of-parent-6360
IAO_0000115: A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase I. Factors required for RNA polymerase I transcription initiation include upstream activation factor (UAF), core factor (CF), TATA binding protein (TBP) and RRN3. In all species characterized, RNA polymerase I transcribes a large polycistronic transcript that is processed into several mature rRNAs (3 or 4 depending on the species), including the large subunit rRNA (28S in humans), the small subunit rRNA (18S in humans), as well as one or two additional smaller rRNAs (the 5.8S rRNA in humans). In most species, this large rRNA transcript is the sole product of RNA polymerase I. However there are rare exceptions, such as Trypanosoma brucei, where RNA polymerase I also transcribes certain mRNAs.
has related synonym: core RNA polymerase I binding transcription factor activity
has exact synonym: general RNA polymerase I transcription factor activity
has exact synonym: RNA polymerase I transcription general initiation factor activity
has related synonym: transcription factor activity, core RNA polymerase I binding

RNA polymerase I promoter clearance
type: Class
subclass of: promoter clearance during DNA-templated transcription
subclass of: part-of-parent-6360
IAO_0000115: A process that mediates the transition from the initiation to the elongation phases of transcription by RNA polymerase I, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors.
has exact synonym: promoter clearance from RNA polymerase I promoter
has related synonym: promoter clearance from RNA polymerase I promoter for nuclear large rRNA transcript
has exact synonym: RNA polymerase I promoter escape
replaces: GO_0001184

obsolete RNA polymerase I transcription regulator recruiting activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The function of binding to an RNA polymerase I (RNAP I) transcription regulator and recruiting it to the general transcription machinery complex in order to modulate transcription initiation.

RNA polymerase I preinitiation complex assembly
type: Class
subclass of: GO_0070897
subclass of: part-of-parent-6361
IAO_0000115: The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase I promoter.
has exact synonym: RNA polymerase I transcriptional preinitiation complex assembly
has related synonym: RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript
has related synonym: RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nucleolar primary rRNA transcript
replaces: GO_0001189

obsolete transcriptional activator activity, RNA polymerase II transcription factor binding
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to increase the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.

obsolete transcriptional repressor activity, RNA polymerase II transcription factor binding
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.

maintenance of transcriptional fidelity during transcription elongation
type: Class
subclass of: GO_0032774
subclass of: part-of-parent-6354
IAO_0000115: Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation on a DNA template.
has exact synonym: maintenance of transcriptional fidelity during DNA-dependent transcription elongation
has exact synonym: maintenance of transcriptional fidelity during DNA-dependent transcription elongation from bacterial-type RNA polymerase promoter
has exact synonym: maintenance of transcriptional fidelity during DNA-templated transcription elongation
has related synonym: maintenance of transcriptional fidelity during DNA-templated transcription elongation from bacterial-type RNA polymerase promoter
replaces: GO_0001194

maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
type: Class
subclass of: maintenance of transcriptional fidelity during transcription elongation
subclass of: part-of-parent-6368
IAO_0000115: Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from an RNA polymerase II promoter.
has exact synonym: maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter
has exact synonym: maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter

maintenance of transcriptional fidelity during transcription elongation by RNA polymerase III
type: Class
subclass of: maintenance of transcriptional fidelity during transcription elongation
subclass of: part-of-parent-6385
IAO_0000115: Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from a RNA polymerase III promoter.
has exact synonym: maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase III promoter
has exact synonym: maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase III promoter

obsolete regulation of mating-type specific transcription from RNA polymerase II promoter
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any mating-type specific process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.

obsolete positive regulation of mating-type specific transcription from RNA polymerase II promoter
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any mating-type specific process that activates or increases the rate of transcription from an RNA polymerase II promoter.

obsolete negative regulation of mating-type specific transcription from RNA polymerase II promoter
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any mating-type specific process that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter.

obsolete histone displacement
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The removal of histones, including histone dimers, from nucleosomes within chromatin.

obsolete histone H2A-H2B dimer displacement
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The removal of a H2A-H2B histone dimer from a nucleosome within chromatin.

DNA-binding transcription activator activity
type: Class
subclass of: DNA-binding transcription factor activity
subclass of: part-of-parent-45893
IAO_0000115: A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets.
has related synonym: bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
has related synonym: bacterial-type RNA polymerase transcriptional activator activity, metal ion regulated sequence-specific DNA binding
has related synonym: bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
has related synonym: metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription
has related synonym: sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription
has related synonym: transcriptional activator activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding
has related synonym: transcriptional activator activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding
replaces: GO_0001140
replaces: GO_0001215

DNA-binding transcription repressor activity
type: Class
subclass of: DNA-binding transcription factor activity
subclass of: part-of-parent-45892
IAO_0000115: A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets.
has related synonym: bacterial-type DNA binding transcription repressor activity
has related synonym: bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
has related synonym: bacterial-type RNA polymerase transcriptional repressor activity, cadmium ion regulated sequence-specific DNA binding
has related synonym: bacterial-type RNA polymerase transcriptional repressor activity, copper ion regulated sequence-specific DNA binding
has related synonym: bacterial-type RNA polymerase transcriptional repressor activity, metal ion regulated sequence-specific DNA binding
has related synonym: bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding
has related synonym: cadmium ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
has related synonym: copper ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
has related synonym: metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
has related synonym: sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
has related synonym: transcriptional repressor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding
has related synonym: transcriptional repressor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding
replaces: GO_0001141
replaces: GO_0001218
replaces: GO_0001219
replaces: GO_0001220

transcription coregulator binding
type: Class
subclass of: GO_0008134
IAO_0000115: Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.
has related synonym: RNA polymerase II transcription cofactor binding
has related synonym: RNA polymerase II transcription coregulator binding
has related synonym: transcription cofactor binding
replaces: GO_0001224

transcription corepressor binding
type: Class
subclass of: transcription coregulator binding
IAO_0000115: Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.
has related synonym: RNA polymerase II transcription corepressor binding
replaces: GO_0001226

transcription coactivator binding
type: Class
subclass of: transcription coregulator binding
IAO_0000115: Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
has related synonym: RNA polymerase II transcription coactivator binding
replaces: GO_0001225

DNA-binding transcription repressor activity, RNA polymerase II-specific
type: Class
subclass of: DNA-binding transcription factor activity, RNA polymerase II-specific
subclass of: DNA-binding transcription repressor activity
subclass of: part-of-parent-122
IAO_0000115: A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II.
has related synonym: distal enhancer DNA-binding transcription repressor activity, RNA polymerase II-specific
has related synonym: metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in negative regulation of transcription
has related synonym: metal ion regulated sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
has related synonym: proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
has related synonym: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
has related synonym: RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in negative regulation of transcription
has related synonym: RNA polymerase II transcriptional repressor activity, metal ion regulated core promoter proximal region sequence-specific binding
has related synonym: RNA polymerase II transcriptional repressor activity, metal ion regulated proximal promoter sequence-specific DNA binding
has exact synonym: RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
has related synonym: sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in negative regulation of transcription
has related synonym: transcriptional repressor activity, metal ion regulated sequence-specific DNA binding
has related synonym: transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
has related synonym: transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
has exact synonym: transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
replaces: GO_0001078
replaces: GO_0001206
replaces: GO_0001210
replaces: GO_0001214

DNA-binding transcription activator activity, RNA polymerase II-specific
type: Class
subclass of: DNA-binding transcription factor activity, RNA polymerase II-specific
subclass of: DNA-binding transcription activator activity
subclass of: part-of-parent-45944
IAO_0000115: A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
has related synonym: copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription
has related synonym: distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific
has related synonym: metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription
has related synonym: metal ion regulated sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
has related synonym: proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
has related synonym: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
has related synonym: RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in positive regulation of transcription
has related synonym: RNA polymerase II transcriptional activator activity, copper ion regulated proximal promoter sequence-specific DNA binding
has related synonym: RNA polymerase II transcriptional activator activity, metal ion regulated core promoter proximal region sequence-specific binding
has related synonym: RNA polymerase II transcriptional activator activity, metal ion regulated proximal promoter sequence-specific DNA binding
has related synonym: RNA polymerase II transcriptional activator activity, zinc ion regulated core promoter proximal region sequence-specific binding
has related synonym: RNA polymerase II transcriptional activator activity, zinc ion regulated proximal promoter sequence-specific DNA binding
has exact synonym: RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
has related synonym: sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in positive regulation of transcription
has related synonym: transcriptional activator activity, metal ion regulated sequence-specific DNA binding
has related synonym: transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
has related synonym: transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
has related synonym: transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
has exact synonym: transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
has related synonym: zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription
replaces: GO_0001077
replaces: GO_0001205
replaces: GO_0001209
replaces: GO_0001211
replaces: GO_0001212
replaces: GO_0001213

obsolete chronological cell aging
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state.

obsolete progressive alteration of chromatin involved in cell aging
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any chromatin organization process that occurs during the lifespan of the cell that results in changes in chromatin structure. Such changes may lead to gene dysregulation and ultimately to a loss in cell homeostasis, bringing about an aging phenotype.

obsolete replicative cell aging
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division.

obsolete nucleolar fragmentation involved in replicative aging
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A nucleolar fragmentation process that gives rise to multiple rounded structures and that occurs in conjunction with increasing age in dividing cells.

obsolete progressive alteration of chromatin involved in replicative cell aging
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A process that results in changes in chromatin structure contributing to replicative cell aging.

obsolete progressive alteration of chromatin involved in chronological cell aging
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A process that results in changes in chromatin structure contributing to chronological cell aging, occurring in non-dividing cells.

obsolete age-dependent response to oxidative stress
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, where the change varies according to the age of the cell or organism.

obsolete extrachromosomal circular DNA accumulation involved in replicative cell aging
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Increase in abundance of circular DNA molecules in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication.

obsolete negative regulation of chromatin silencing involved in replicative cell aging
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The process, which occurs as a dividing cell ages, leading to expression of genes that are typically not expressed due to silencing by regulatory proteins.

obsolete age-dependent telomere shortening
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Progressive reduction in length of the telomeres, the termini of eukaryotic chromosomes, that occurs as part of the cellular aging process.

obsolete extrachromosomal rDNA circle accumulation involved in replicative cell aging
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Increase in abundance of circular DNA molecules containing ribosomal DNA repeats in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication.

obsolete formation of extrachromosomal circular rDNA by homologous recombination involved in replicative cell aging
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Excision from the chromosome and circularization of DNA molecules encoding ribosomal RNA in dividing cells as they age.

obsolete replication of extrachromosomal rDNA circles involved in replicative cell aging
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Replication of rDNA following its excision from the chromosome of dividing cells as they age. Extrachromosomal rDNA forms a circle that contains at least one autonomously replicating sequence (ARS), which supports replication independent of chromosomal replication.

obsolete formation of extrachromosomal circular DNA involved in replicative cell aging
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats, in dividing cells as they age.

obsolete replication of extrachromosomal circular DNA involved in replicative cell aging
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Replication of circular DNA following excision from the chromosome of dividing cells as they age; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication.

obsolete age-dependent response to reactive oxygen species
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism.

obsolete age-dependent response to reactive oxygen species involved in replicative cell aging
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring during the process of replicative cell aging as a result of reactive oxygen species, where the change varies according to the age of the cell or organism.

obsolete accumulation of oxidatively modified proteins involved in replicative cell aging
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Accumulation of proteins that have undergone reactions with reactive oxygen species in aging dividing cells and exhibit modifications such as increased protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking.

obsolete formation of oxidatively modified proteins involved in replicative cell aging
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Chemical reaction, between proteins and reactive oxygen species, that occurs in dividing cells as they age and leads to a variety of changes in the affected proteins, including increases in protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking.

obsolete inheritance of oxidatively modified proteins involved in replicative cell aging
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A protein localization process in which progeny cells acquire, or are barred from acquiring, proteins that have been altered by reaction with reactive oxygen species in dividing aging cells.

obsolete age-dependent response to reactive oxygen species involved in chronological cell aging
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of reactive oxygen species, where the change varies according to the age of the cell or organism.

obsolete age-dependent general metabolic decline involved in replicative cell aging
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A process of general metabolic decline that arises in dividing cells as they age, and alters cellular metabolism to cause a decline in cell function.

obsolete age-dependent response to oxidative stress involved in replicative cell aging
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism.

obsolete age-dependent general metabolic decline involved in chronological cell aging
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A process of general metabolic decline that arises in non-dividing cells as they age, and alters cellular metabolism to cause a decline in cell function.

obsolete age-dependent response to oxidative stress involved in chronological cell aging
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism.

formation of extrachromosomal circular DNA
type: Class
subclass of: GO_0006259
subclass of: GO_0022607
IAO_0000115: Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats.
has exact synonym: assembly of extrachromosomal circular DNA

replication of extrachromosomal circular DNA
type: Class
subclass of: GO_0006261
IAO_0000115: Replication of circular DNA following excision from the chromosome; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication.

mating projection base
type: Class
subclass of: GO_0110165
subclass of: part-of-parent-5937
IAO_0000115: The region where the mating projection meets the bulk of the cell, in unicellular fungi exposed to mating pheromone.
has related synonym: base of shmoo tip
has related synonym: conjugation tube base

SAM complex
type: Class
subclass of: GO_0005742
IAO_0000115: A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex.
has exact synonym: mitochondrial sorting and assembly machinery complex
has exact synonym: TOB complex

signal transduction involved in filamentous growth
type: Class
subclass of: GO_0007165
subclass of: part-of-parent-30447
IAO_0000115: Relaying of environmental signals promoting filamentous growth.
has related synonym: MAPKKK cascade (pseudohyphal growth)
has related synonym: signal transduction during filamentous growth

invasive growth in response to glucose limitation
type: Class
subclass of: GO_0036267
IAO_0000115: A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. An example of this process is found in Saccharomyces cerevisiae.
has related synonym: colony morphology

obsolete invasive growth
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Growth of a pathogenic organism that results in penetration into cells or tissues of the host organism. This often (but not necessarily) includes a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue.

PAM complex, Tim23 associated import motor
type: Class
subclass of: GO_0098800
subclass of: part-of-parent-5744
subclass of: part-of-parent-5759
IAO_0000115: Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the TIM23 mitochondrial import inner membrane translocase complex (GO:0005744); ATPase motor activity to drive import of proteins into the mitochondrial matrix.
has exact synonym: mitochondrial import motor
has exact synonym: PAM complex
has exact synonym: presequence translocase-associated import motor
has exact synonym: pre-sequence translocase-associated import motor

glycerophosphodiester transmembrane transporter activity
type: Class
subclass of: GO_0008514
subclass of: GO_0015605
subclass of: part-of-parent-1407
IAO_0000115: Enables the transfer of glycerophosphodiesters from one side of a membrane to the other. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol.

glycerophosphodiester transmembrane transport
type: Class
subclass of: GO_0015711
subclass of: GO_0015748
subclass of: GO_0098656
IAO_0000115: The process in which a glycerophosphodiester is transported across a membrane. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol.

guanine nucleotide transport
type: Class
subclass of: GO_0015865
IAO_0000115: The directed movement of guanine nucleotides, GTP, GDP, and/or GMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

guanine nucleotide transmembrane transporter activity
type: Class
subclass of: GO_0015216
subclass of: part-of-parent-1903790
IAO_0000115: Enables the transfer of guanine nucleotides (GMP, GDP, and GTP) from one side of a membrane to the other.

chlamydospore formation
type: Class
subclass of: GO_0043936
subclass of: GO_0048468
IAO_0000115: The process whose specific outcome is the progression of the chlamydospore over time, from its formation to the mature structure. A chlamydospores is a mitotic (asexual) one-celled spore, produced primarily for survival, not dispersal, originating endogenously and singly within part of a pre-existing cell and possessing an inner secondary and often thickened cell wall. An example of this is found in Candida albicans.
has exact synonym: chlamydospore development
replaces: GO_0055027

hyphal tip
type: Class
subclass of: GO_0030427
subclass of: GO_0051286
IAO_0000115: The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation.

skeletal system development
type: Class
subclass of: GO_0048731
IAO_0000115: The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
has exact synonym: skeletal development

cartilage condensation
type: Class
subclass of: GO_0098743
subclass of: part-of-parent-48705
subclass of: part-of-parent-51216
IAO_0000115: The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes.

ossification
type: Class
subclass of: GO_0032501
IAO_0000115: The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
has exact synonym: bone biosynthesis
has exact synonym: bone formation
has exact synonym: osteogenesis

neurotransmitter uptake
type: Class
subclass of: regulation of neurotransmitter levels
subclass of: GO_0006836
subclass of: GO_0098657
IAO_0000115: The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters.
has exact synonym: neurotransmitter import
has related synonym: neurotransmitter import into glial cell
has related synonym: neurotransmitter import into neuron
has related synonym: neurotransmitter recycling

regulation of neurotransmitter levels
type: Class
subclass of: GO_0065008
IAO_0000115: Any process that modulates levels of neurotransmitter.

obsolete neurotransmitter biosynthetic process and storage
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The chemical reactions and pathways resulting in the formation of neurotransmitters and the storage of the synthesized molecules.

acetylcholine catabolic process in synaptic cleft
type: Class
subclass of: GO_0006581
subclass of: part-of-parent-7271
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of acetylcholine that occurs in the synaptic cleft during synaptic transmission.
has exact synonym: acetylcholine breakdown in synaptic cleft
has exact synonym: acetylcholine degradation in synaptic cleft

action potential
type: Class
subclass of: GO_0042391
IAO_0000115: A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities.

obsolete legumain activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of proteins and small-molecule substrates at Asn-Xaa bonds.

RNA methylation
type: Class
subclass of: GO_0009451
subclass of: GO_0043414
IAO_0000115: Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor.

obsolete fibrillin
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Large glycoprotein that is a calcium binding component of connective tissue microfibrils containing 34 six-cysteine (EGF-like) repeats and five eight-cysteine (TGFbeta-1 binding protein-like) repeats. Defects associated with Marfan syndrome.

dihydronicotinamide riboside quinone reductase activity
type: Class
subclass of: GO_0016679
IAO_0000115: Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone.
has related synonym: NQO(2) activity
has related synonym: NQO2
has related synonym: NRH:quinone oxidoreductase 2 activity
has related synonym: N-ribosyldihydronicotinamide dehydrogenase (quinone) activity
has related synonym: QR2 activity
has related synonym: quinone reductase 2 activity
has exact synonym: ribosyldihydronicotinamide dehydrogenase (quinone) activity

selenocysteine incorporation
type: Class
subclass of: GO_0006451
IAO_0000115: The incorporation of selenocysteine into a peptide; uses a special tRNA that recognizes the UGA codon as selenocysteine, rather than as a termination codon. Selenocysteine is synthesized from serine before its incorporation; it is not a posttranslational modification of peptidyl-cysteine.

opioid peptide activity
type: Class
subclass of: GO_0048018
IAO_0000115: Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect.

prostaglandin biosynthetic process
type: Class
subclass of: GO_0006693
subclass of: GO_0046457
IAO_0000115: The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring.
has exact synonym: prostaglandin anabolism
has exact synonym: prostaglandin biosynthesis
has exact synonym: prostaglandin formation
has exact synonym: prostaglandin synthesis

N-acetylglucosamine 6-O-sulfotransferase activity
type: Class
subclass of: GO_0008146
IAO_0000115: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate.
has exact synonym: N-acetylglucosamine 6-O-sulphotransferase activity

voltage-gated sodium channel complex
type: Class
subclass of: GO_0034706
subclass of: GO_0098797
subclass of: part-of-parent-5887
IAO_0000115: A sodium channel in a cell membrane whose opening is governed by the membrane potential.
has exact synonym: voltage-dependent sodium channel complex
has exact synonym: voltage gated sodium channel complex
has exact synonym: voltage-sensitive sodium channel complex

peptide amidation
type: Class
subclass of: GO_0031179
IAO_0000115: The posttranslational conversion of C-terminal glycine-extended peptides to C-terminal alpha-amidated peptides. Occurs to over half of all peptide hormones to give bioactive peptides. This is a two step process catalyzed by a peptidyl-glycine alpha-hydroxylating monooxygenase and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase. In some organisms, this process is catalyzed by two separate enzymes, whereas in higher organisms, one polypeptide catalyzes both reactions.

outer dense fiber
type: Class
subclass of: GO_0099513
subclass of: part-of-parent-36126
IAO_0000115: A supramolecular fiber found in the flagella of mammalian sperm that surrounds the nine microtubule doublets. These dense fibers are stiff and noncontractile. In human, they consist of about 10 major and at least 15 minor proteins, where all major proteins are ODF1, ODF2 or ODF2-related proteins.
has exact synonym: outer dense fibre

pseudouridine synthesis
type: Class
subclass of: GO_0009451
IAO_0000115: The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs.
has exact synonym: pseudouridylation

retinoid metabolic process
type: Class
subclass of: GO_0016101
IAO_0000115: The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.
has exact synonym: retinoid metabolism

obsolete globin
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The colorless and basic protein moiety of hemoglobin and myoglobins.

angiogenesis
type: Class
subclass of: GO_0048646
subclass of: part-of-parent-48514
IAO_0000115: Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
has exact synonym: blood vessel formation from pre-existing blood vessels

obsolete proteoglycan sulfate transfer
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Transfer of sulfate to a proteoglycan (a glycoprotein whose carbohydrate units are glycosaminoglycans) using 3'-phosphoadenyl sulfate.

microfibril
type: Class
subclass of: GO_0099512
subclass of: part-of-parent-31012
IAO_0000115: Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins.
has exact synonym: extended fibrils
has related synonym: fibrillin

obsolete elastin
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A major structural protein of mammalian connective tissues; composed of one third glycine, and also rich in proline, alanine, and valine. Chains are cross-linked together via lysine residues.

obsolete elastin
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

lipopolysaccharide binding
type: Class
subclass of: GO_0008289
subclass of: GO_0097367
IAO_0000115: Binding to a lipopolysaccharide.
has related synonym: endotoxin binding
has exact synonym: LPS binding

interleukin-21 receptor binding
type: Class
subclass of: GO_0005126
IAO_0000115: Binding to an interleukin-21 receptor.
has related synonym: IL-21
has related synonym: interleukin-21 receptor ligand

interleukin-21 receptor activity
type: Class
subclass of: GO_0004896
subclass of: part-of-parent-38114
IAO_0000115: Combining with interleukin-21 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has exact synonym: IL-21R
has exact synonym: IL-21 receptor activity

cornified envelope
type: Class
subclass of: GO_0005886
IAO_0000115: A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes).

radial spoke
type: Class
subclass of: GO_0032991
subclass of: part-of-parent-5930
IAO_0000115: Protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules.

radial spoke head
type: Class
subclass of: GO_0032991
subclass of: part-of-parent-1534
IAO_0000115: Protein complex forming part of eukaryotic flagellar apparatus.
has exact synonym: radial spokehead

radial spoke stalk
type: Class
subclass of: GO_0032991
subclass of: part-of-parent-1534
IAO_0000115: Globular portion of the radial spoke that projects towards the central pair of microtubules.

N-acetylgalactosamine 4-O-sulfotransferase activity
type: Class
subclass of: GO_0008146
IAO_0000115: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate.
has exact synonym: N-acetylgalactosamine 4-O-sulphotransferase activity

cilium or flagellum-dependent cell motility
type: Class
subclass of: GO_0048870
IAO_0000115: Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella.
has exact synonym: ciliary/flagellar motility
has related synonym: ciliary or bacterial-type flagellar motility

amyloid-beta binding
type: Class
subclass of: GO_0042277
IAO_0000115: Binding to an amyloid-beta peptide/protein.
has exact synonym: beta-amyloid binding

ovarian follicle development
type: Class
subclass of: developmental process involved in reproduction
subclass of: GO_0048856
subclass of: part-of-parent-8585
IAO_0000115: The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.
has related synonym: follicular phase

ovulation from ovarian follicle
type: Class
subclass of: GO_0022602
subclass of: GO_0030728
subclass of: part-of-parent-8585
IAO_0000115: The process leading to the rupture of the follicle, releasing the centrally located oocyte into the oviduct. An example of this is found in Mus musculus.

ovarian follicle rupture
type: Class
subclass of: GO_0022602
subclass of: part-of-parent-1542
IAO_0000115: Disruption of theca cell layer releasing follicular fluid and/or the oocyte.

initiation of primordial ovarian follicle growth
type: Class
subclass of: GO_0022602
subclass of: part-of-parent-1541
IAO_0000115: Increase in size of primordial follicles including proliferation and shape changes of granulosa and/or theca cells until oocyte is surrounded by one layer of cuboidal shaped granulosa cells (primary follicle).

primary ovarian follicle growth
type: Class
subclass of: GO_0022602
subclass of: GO_0048589
subclass of: part-of-parent-1541
IAO_0000115: Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle).

preantral ovarian follicle growth
type: Class
subclass of: GO_0022602
subclass of: GO_0048589
subclass of: part-of-parent-1541
subclass of: part-of-parent-48162
IAO_0000115: Increase in size of follicles surrounded by two or more layers of granulosa cells up to the onset of antrum formation.

antral ovarian follicle growth
type: Class
subclass of: developmental process involved in reproduction
subclass of: GO_0022602
subclass of: GO_0048589
subclass of: part-of-parent-1541
IAO_0000115: Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity.

follicular fluid formation in ovarian follicle antrum
type: Class
subclass of: GO_0022602
subclass of: part-of-parent-1547
IAO_0000115: The menstrual cycle process that results in the formation of one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells during the various stages of oogenesis.
has exact synonym: ovarian follicle antrum/follicular fluid biosynthesis
has exact synonym: ovarian follicle antrum/follicular fluid formation

cumulus cell differentiation
type: Class
subclass of: developmental process involved in reproduction
subclass of: GO_0022412
subclass of: GO_0022602
subclass of: GO_0030855
subclass of: part-of-parent-1547
subclass of: part-of-parent-48165
IAO_0000115: The process in which a subpopulation of granulosa cells surrounding the oocyte acquires the specialized features of an ovarian cumulus cell.
has exact synonym: ovarian cumulus cell differentiation

ovarian cumulus expansion
type: Class
subclass of: GO_0022602
subclass of: GO_0048589
subclass of: part-of-parent-1547
subclass of: part-of-parent-48165
IAO_0000115: Increase in size of the cumulus surrounding the oocyte including change in morphology due to proliferation and dispersion of cumulus cells.
has related synonym: ovarian cumulus growth

ovarian follicle endowment
type: Class
subclass of: GO_0022602
subclass of: part-of-parent-1541
IAO_0000115: Association of oocytes with supporting epithelial granulosa cells to form primordial follicles.

ovarian follicle atresia
type: Class
subclass of: developmental process involved in reproduction
subclass of: part-of-parent-8585
IAO_0000115: A periodic process in which immature ovarian follicles degenerate and are subsequently re-absorbed.

luteinization
type: Class
subclass of: GO_0022602
subclass of: part-of-parent-8585
IAO_0000115: The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation.
has related synonym: luteal phase

luteolysis
type: Class
subclass of: GO_0022602
subclass of: part-of-parent-8585
IAO_0000115: The lysis or structural demise of the corpus luteum. During normal luteolysis, two closely related events occur. First, there is loss of the capacity to synthesize and secrete progesterone (functional luteolysis) followed by loss of the cells that comprise the corpus luteum (structural luteolysis). Preventing luteolysis is crucial to maintain pregnancy.

oocyte growth
type: Class
subclass of: developmental process involved in reproduction
subclass of: GO_0022412
subclass of: GO_0048588
subclass of: part-of-parent-48599
IAO_0000115: The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.

oocyte maturation
type: Class
subclass of: developmental process involved in reproduction
subclass of: GO_0022412
subclass of: GO_0048469
subclass of: part-of-parent-48599
IAO_0000115: A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization.

obsolete metabolic process resulting in cell growth
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The chemical reactions that occur in living organisms that result in an increase in the mass (size) of a cell.

regulation of cell growth
type: Class
subclass of: GO_0040008
subclass of: GO_0051128
IAO_0000115: Any process that modulates the frequency, rate, extent or direction of cell growth.

obsolete regulation of cell growth by detection of nuclear:cytoplasmic ratio
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any process in which the size of the nucleus with respect to the cytoplasm modulates the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time.

regulation of cell growth by extracellular stimulus
type: Class
subclass of: regulation of cell growth
subclass of: part-of-parent-31668
IAO_0000115: Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time.
has exact synonym: interpretation of external signals that regulate cell growth
has exact synonym: regulation of cell growth by detection of exogenous stimulus
has exact synonym: regulation of cell growth by sensing of exogenous stimulus
has exact synonym: regulation of growth by exogenous signal
has exact synonym: regulation of growth by exogenous stimuli
has exact synonym: regulation of growth by exogenous stimulus
has exact synonym: regulation of growth by external signal
has exact synonym: regulation of growth by external stimuli
has exact synonym: regulation of growth by external stimulus

fatty acid alpha-oxidation
type: Class
subclass of: GO_0009062
subclass of: GO_0019395
IAO_0000115: A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway.

response to protozoan
type: Class
subclass of: GO_0051707
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan.
has related synonym: resistance to pathogenic protozoa
has exact synonym: response to protozoa
has exact synonym: response to protozoon
replaces: GO_0042833

detection of protozoan
type: Class
subclass of: response to protozoan
subclass of: GO_0098543
IAO_0000115: The series of events in which a stimulus from a protozoan is received and converted into a molecular signal.
has exact synonym: detection of protozoa
has exact synonym: detection of protozoon
has related synonym: perception of protozoa

obsolete resistance to pathogenic protozoa
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

phorbol ester receptor activity
type: Class
subclass of: GO_0038023
IAO_0000115: Combining with a phorbol ester and transmitting the signal to initiate a change in cell activity.

non-kinase phorbol ester receptor activity
type: Class
subclass of: phorbol ester receptor activity
IAO_0000115: Combining with a phorbol ester and transmitting the signal by a mechanism independent of kinase activity.

cholesterol 25-hydroxylase activity
type: Class
subclass of: GO_0008395
subclass of: GO_0016705
IAO_0000115: Catalysis of the reaction: AH(2) + cholesterol + O(2) = 25-hydroxycholesterol + A + H(2)O.
has related synonym: cholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating) activity
has related synonym: cholesterol 25-monooxygenase activity

blood vessel development
type: Class
subclass of: GO_0048856
subclass of: part-of-parent-1944
IAO_0000115: The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.

branching involved in blood vessel morphogenesis
type: Class
subclass of: GO_0048754
subclass of: part-of-parent-1525
subclass of: part-of-parent-48514
IAO_0000115: The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.
has related synonym: patterning of blood vessels

vasculogenesis
type: Class
subclass of: GO_0030154
subclass of: part-of-parent-48514
IAO_0000115: The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
has exact synonym: vascular morphogenesis

non-tyrosine kinase fibroblast growth factor receptor activity
type: Class
subclass of: GO_0004888
IAO_0000115: Combining with fibroblast growth factor (FGF) and transmitting the signal from one side of the membrane to the other by a mechanism independent of tyrosine kinase activity.
has exact synonym: non-tyrosine kinase FGFR activity
has exact synonym: non-tyrosine kinase FGF receptor activity

lactosylceramide biosynthetic process
type: Class
subclass of: GO_0006688
subclass of: GO_0046478
subclass of: GO_0046513
IAO_0000115: The chemical reactions and pathways resulting in the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides.
has exact synonym: lactosylceramide anabolism
has exact synonym: lactosylceramide biosynthesis
has exact synonym: lactosylceramide formation
has exact synonym: lactosylceramide synthesis

ganglioside metabolic process
type: Class
subclass of: GO_0006672
subclass of: GO_0006687
IAO_0000115: The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues.
has exact synonym: ganglioside metabolism

ganglioside biosynthetic process
type: Class
subclass of: ganglioside metabolic process
subclass of: GO_0006688
subclass of: GO_0046513
IAO_0000115: The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues.
has exact synonym: ganglioside anabolism
has exact synonym: ganglioside biosynthesis
has exact synonym: ganglioside formation
has exact synonym: ganglioside synthesis

globoside metabolic process
type: Class
subclass of: GO_0006687
IAO_0000115: The chemical reactions and pathways involving globosides, globotetraosylceramides, ceramides containing a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I). Globosides are the major neutral glycosphingolipid in normal kidneys and erythrocytes.
has exact synonym: globoside metabolism

globoside biosynthetic process
type: Class
subclass of: globoside metabolic process
subclass of: GO_0006688
IAO_0000115: The chemical reactions and pathways resulting in the formation of a ceramide with a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I).
has exact synonym: globoside anabolism
has exact synonym: globoside biosynthesis
has exact synonym: globoside formation
has exact synonym: globoside synthesis

obsolete galectin
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A lectin that exhibits calcium independent binding of beta-galactoside sugars.

microtubule bundle formation
type: Class
subclass of: microtubule cytoskeleton organization
IAO_0000115: A process that results in a parallel arrangement of microtubules.
has exact synonym: microtubule bundling

medium-chain fatty acid transport
type: Class
subclass of: GO_0006869
subclass of: GO_0015718
IAO_0000115: The directed movement of medium-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12.

detection of chemical stimulus involved in sensory perception of bitter taste
type: Class
subclass of: GO_0050912
subclass of: part-of-parent-50913
IAO_0000115: The series of events required for a bitter taste stimulus to be received and converted to a molecular signal.
has exact synonym: bitter taste detection
has exact synonym: perception of bitter taste, detection of chemical stimulus
has exact synonym: perception of bitter taste, sensory transduction of chemical stimulus
has exact synonym: sensory detection of bitter taste
has exact synonym: sensory detection of chemical stimulus during perception of bitter taste
has exact synonym: sensory transduction of bitter taste
has exact synonym: sensory transduction of chemical stimulus during perception of bitter taste

detection of chemical stimulus involved in sensory perception of sour taste
type: Class
subclass of: GO_0050912
subclass of: part-of-parent-50915
IAO_0000115: The series of events required for a sour taste stimulus to be received and converted to a molecular signal.
has exact synonym: perception of sour taste, detection of chemical stimulus
has exact synonym: perception of sour taste, sensory transduction of chemical stimulus
has exact synonym: sensory detection of chemical stimulus during perception of sour taste
has exact synonym: sensory detection of sour taste
has exact synonym: sensory transduction of chemical stimulus during perception of sour taste
has exact synonym: sensory transduction of sour taste
has exact synonym: sour taste detection

detection of chemical stimulus involved in sensory perception of sweet taste
type: Class
subclass of: GO_0050912
subclass of: part-of-parent-50916
IAO_0000115: The series of events required for a sweet taste stimulus to be received and converted to a molecular signal.
has exact synonym: perception of sweet taste, detection of chemical stimulus
has exact synonym: perception of sweet taste, sensory transduction of chemical stimulus
has exact synonym: sensory detection of chemical stimulus during perception of sweet taste
has exact synonym: sensory detection of sweet taste
has exact synonym: sensory transduction of chemical stimulus during perception of sweet taste
has exact synonym: sensory transduction of sweet taste
has exact synonym: sweet taste detection

detection of chemical stimulus involved in sensory perception of salty taste
type: Class
subclass of: GO_0050912
subclass of: part-of-parent-50914
IAO_0000115: The series of events required for a salty taste stimulus to be received and converted to a molecular signal.
has exact synonym: perception of salty taste, detection of chemical stimulus
has exact synonym: perception of salty taste, sensory transduction of chemical stimulus
has exact synonym: salty taste detection
has exact synonym: sensory detection of chemical stimulus during perception of salty taste
has exact synonym: sensory detection of salty taste
has exact synonym: sensory transduction of chemical stimulus during perception of salty taste
has exact synonym: sensory transduction of salty taste

obsolete rhodopsin-like receptor activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A G protein-coupled receptor that is structurally/functionally related to the rhodopsin receptor.
replaces: GO_0001620

Gi/o-coupled serotonin receptor activity
type: Class
subclass of: GO_0004993
IAO_0000115: Combining with serotonin and transmitting the signal across the membrane by activation of the Gi/o subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gi/o subunit subsequently inhibits adenylate cyclase and results in a decrease in cyclic AMP (cAMP) levels.
has exact synonym: 5-HT1 receptor activity
has exact synonym: serotonin receptor activity, coupled via Gi/o

Gq/11-coupled serotonin receptor activity
type: Class
subclass of: GO_0004993
IAO_0000115: Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels.
has related synonym: 5-HT2 receptor activity
has exact synonym: serotonin receptor activity, coupled via Gq/11

dopamine neurotransmitter receptor activity, coupled via Gs
type: Class
subclass of: GO_0004952
IAO_0000115: Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity.
has related synonym: dopamine D1 receptor activity
has related synonym: dopamine D5 receptor activity
replaces: GO_0001589
replaces: GO_0001590

dopamine neurotransmitter receptor activity, coupled via Gi/Go
type: Class
subclass of: GO_0004952
IAO_0000115: Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity.
has related synonym: dopamine D2 receptor activity
has related synonym: dopamine D3 receptor activity
has related synonym: dopamine D4 receptor activity
replaces: GO_0001592
replaces: GO_0001593
replaces: GO_0001670

trace-amine receptor activity
type: Class
subclass of: GO_0008227
IAO_0000115: Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals.

angiotensin receptor activity
type: Class
subclass of: GO_0008528
subclass of: part-of-parent-38166
IAO_0000115: Combining with angiotensin to initiate a change in cell activity.

angiotensin type I receptor activity
type: Class
subclass of: angiotensin receptor activity
subclass of: part-of-parent-86097
IAO_0000115: An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms.
has exact synonym: PLC-activating angiotensin receptor activity

obsolete apelin-like receptor
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete chemokine receptor-like receptor activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

peptide YY receptor activity
type: Class
subclass of: GO_0004983
IAO_0000115: Combining with gut peptide YY to initiate a change in cell activity.

pancreatic polypeptide receptor activity
type: Class
subclass of: GO_0004983
IAO_0000115: Combining with pancreatic polypeptide PP to initiate a change in cell activity.

obsolete vasopressin-like receptor activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

urotensin II receptor activity
type: Class
subclass of: GO_0008528
IAO_0000115: Combining with urotensin II to initiate a change in cell activity.

adrenomedullin receptor activity
type: Class
subclass of: GO_0097642
IAO_0000115: Combining with adrenomedullin to initiate a change in cell activity.
has related synonym: G10D receptor

obsolete GPR37/endothelin B-like receptor activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

neuromedin U receptor activity
type: Class
subclass of: GO_0008188
IAO_0000115: Combining with neuromedin U to initiate a change in cell activity.
has exact synonym: NMUR activity

G protein-coupled nucleotide receptor activity
type: Class
subclass of: GO_0004930
IAO_0000115: Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
has exact synonym: G protein coupled nucleotide receptor activity
has exact synonym: G-protein coupled nucleotide receptor activity
has exact synonym: nucleotide receptor activity, G protein coupled
has exact synonym: nucleotide receptor activity, G-protein coupled

G protein-coupled adenosine receptor activity
type: Class
subclass of: GO_0004930
subclass of: part-of-parent-1973
IAO_0000115: Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
has related synonym: A1 adenosine receptor activity, G protein coupled
has related synonym: A1 adenosine receptor activity, G-protein coupled
has related synonym: A2A adenosine receptor activity, G protein coupled
has related synonym: A2A adenosine receptor activity, G-protein coupled
has related synonym: A2B adenosine receptor activity, G protein coupled
has related synonym: A2B adenosine receptor activity, G-protein coupled
has related synonym: A3 adenosine receptor activity, G protein coupled
has related synonym: A3 adenosine receptor activity, G-protein coupled
has related synonym: adenosine nucleotide receptor
has exact synonym: adenosine receptor activity, G protein coupled
has exact synonym: adenosine receptor activity, G-protein coupled
has related synonym: G protein coupled A1 adenosine receptor activity
has related synonym: G-protein-coupled A1 adenosine receptor activity
has related synonym: G protein coupled A2A adenosine receptor activity
has related synonym: G-protein-coupled A2A adenosine receptor activity
has related synonym: G protein coupled A2B adenosine receptor activity
has related synonym: G-protein-coupled A2B adenosine receptor activity
has related synonym: G protein coupled A3 adenosine receptor activity
has related synonym: G-protein-coupled A3 adenosine receptor activity
has exact synonym: G protein coupled adenosine receptor activity
has exact synonym: G-protein coupled adenosine receptor activity
has exact synonym: P1 receptor
replaces: GO_0001610
replaces: GO_0001611
replaces: GO_0001612
replaces: GO_0001613
replaces: GO_0008501

purinergic nucleotide receptor activity
type: Class
subclass of: GO_0016502
subclass of: part-of-parent-35590
IAO_0000115: Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has related synonym: P2 receptor
has related synonym: purinergic receptor activity
has exact synonym: purinoceptor
has exact synonym: purinoreceptor
replaces: GO_0035586

obsolete thyrotropin releasing hormone and secretagogue-like receptors activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

growth hormone secretagogue receptor activity
type: Class
subclass of: GO_0004930
IAO_0000115: Combining with ghrelin to initiate a change in cell activity.
has exact synonym: ghrelin receptor activity

obsolete growth hormone secretagogue-like receptor activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

virus receptor activity
type: Class
subclass of: GO_0140272
subclass of: part-of-parent-46718
IAO_0000115: Combining with a virus component and mediating entry of the virus into the cell.
has exact synonym: viral receptor activity

obsolete lysosphingolipid and lysophosphatidic acid receptor activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Combining with lysosphingolipid or lysophosphatidic acid to initiate a change in cell activity.

G protein-coupled ADP receptor activity
type: Class
subclass of: GO_0045028
IAO_0000115: Combining with ADP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
has related synonym: ADP-activated adenosine receptor activity
has related synonym: ADP-activated nucleotide receptor activity
has related synonym: ADP receptor activity
has related synonym: K101 receptor
has related synonym: platelet ADP receptor activity
replaces: GO_0045032

nociceptin receptor activity
type: Class
subclass of: GO_0004985
IAO_0000115: Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein.
has exact synonym: nociceptin/orphanin-FQ receptor activity
has exact synonym: OFQ receptor activity
has exact synonym: orphanin-FQ receptor activity
has exact synonym: ORPH receptor
has related synonym: X-opioid receptor activity

obsolete leucine-rich G-protein receptor-like receptor activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete gastropyloric receptor activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete G-protein receptor 45-like receptor activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete GP40-like receptor activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

cysteinyl leukotriene receptor activity
type: Class
subclass of: GO_0004974
IAO_0000115: Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine.
has exact synonym: CysLT receptor

leukotriene B4 receptor activity
type: Class
subclass of: GO_0004974
IAO_0000115: Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate.
has related synonym: BLT receptor

obsolete secretin-like receptor activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A G protein-coupled receptor that is structurally/functionally related to the secretin receptor.
replaces: GO_0001638

pituitary adenylate cyclase-activating polypeptide receptor activity
type: Class
subclass of: GO_0004930
IAO_0000115: A G protein-coupled receptor that interacts with pituitary adenylate cyclase-activating polypeptide.
has exact synonym: PACAP receptor
has related synonym: pituitary adenylate cyclase-activating peptide receptor activity
has exact synonym: pituitary adenylate cyclase activating polypeptide receptor
has exact synonym: pituitary adenylate cyclase activating protein receptor activity
has exact synonym: pituitary adenylyl cyclase activating protein receptor activity
replaces: GO_0016522

calcitonin gene-related peptide receptor activity
type: Class
subclass of: GO_0097642
IAO_0000115: Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity.
has exact synonym: calcitonin gene-related polypeptide receptor activity
has exact synonym: CGRP receptor

obsolete corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

G protein-coupled chemoattractant receptor activity
type: Class
subclass of: GO_0008528
IAO_0000115: Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
has exact synonym: G protein chemoattractant receptor activity
has exact synonym: G-protein chemoattractant receptor activity
has exact synonym: G-protein coupled chemoattractant receptor activity

PLC activating G protein-coupled glutamate receptor activity
type: Class
subclass of: GO_0098988
subclass of: part-of-parent-7206
IAO_0000115: A G protein-coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system.
has related synonym: Group I metabotropic glutamate receptor
has related synonym: group I metabotropic glutamate receptor activity
has exact synonym: phospholipase C activating metabotropic glutamate receptor activity
has exact synonym: PLC activating G-protein coupled glutamate receptor activity
has exact synonym: PLC activating metabotropic glutamate receptor activity

adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
type: Class
subclass of: GO_0098988
subclass of: part-of-parent-7196
IAO_0000115: Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity.
has related synonym: adenylate cyclase inhibiting metabotropic glutamate receptor activity
has exact synonym: adenylyl cyclase inhibiting metabotropic glutamate receptor activity

group II metabotropic glutamate receptor activity
type: Class
subclass of: adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
IAO_0000115: A G protein-coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity.

group III metabotropic glutamate receptor activity
type: Class
subclass of: adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
IAO_0000115: A G protein-coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity.

cAMP receptor activity
type: Class
subclass of: GO_0045028
IAO_0000115: Combining with cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has exact synonym: 3',5' cAMP receptor activity
has exact synonym: 3',5'-cAMP receptor activity
has exact synonym: adenosine 3',5'-cyclophosphate receptor activity
has related synonym: class E GPCR
has related synonym: class E G protein coupled receptor
has related synonym: class E G-protein coupled receptor
has exact synonym: cyclic AMP receptor activity
replaces: GO_0001644

G protein-coupled cytokinin receptor activity
type: Class
subclass of: GO_0004930
subclass of: GO_0009884
IAO_0000115: Combining with cytokinin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
has exact synonym: cytokinin receptor activity, G-protein coupled
has exact synonym: G protein coupled cytokinin receptor activity
has exact synonym: G-protein coupled cytokinin receptor activity

proteinase-activated receptor activity
type: Class
subclass of: GO_0008528
IAO_0000115: A G protein-coupled receptor activity that is activated by cleavage by a serine protease, exposing a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it.
has exact synonym: protease-activated receptor activity
has exact synonym: proteinase activated receptor activity

osteoblast differentiation
type: Class
subclass of: GO_0030154
subclass of: part-of-parent-1503
IAO_0000115: The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
has exact synonym: osteoblast cell differentiation

fibrillar center
type: Class
subclass of: GO_0110165
subclass of: part-of-parent-5730
IAO_0000115: A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
has exact synonym: fibrillar centre

dense fibrillar component
type: Class
subclass of: GO_0110165
subclass of: part-of-parent-5730
IAO_0000115: A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins.
has related synonym: pars fibrosa

granular component
type: Class
subclass of: GO_0110165
subclass of: part-of-parent-5730
IAO_0000115: A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm.
has related synonym: pars granulosa

peptide receptor activity
type: Class
subclass of: GO_0038023
IAO_0000115: Combining with an extracellular or intracellular peptide to initiate a change in cell activity.
has related synonym: endogenous peptide receptor activity
has related synonym: exogenous peptide receptor activity

eye development
type: Class
subclass of: GO_0007423
subclass of: part-of-parent-150063
IAO_0000115: The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.
replaces: GO_0042460

urogenital system development
type: Class
subclass of: GO_0048731
IAO_0000115: The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure.

metanephros development
type: Class
subclass of: kidney development
IAO_0000115: The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine.

ureteric bud development
type: Class
subclass of: GO_0072164
IAO_0000115: The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure.

branching involved in ureteric bud morphogenesis
type: Class
subclass of: GO_0048754
subclass of: part-of-parent-60675
IAO_0000115: The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.
has exact synonym: ureteric bud branching

temperature homeostasis
type: Class
subclass of: GO_0048871
IAO_0000115: A homeostatic process in which an organism modulates its internal body temperature.
has exact synonym: thermoregulation

fever generation
type: Class
subclass of: GO_0006953
subclass of: GO_0031649
IAO_0000115: The heat generation process that results in a rise in body temperature above the normal, often as a response to infection.
has related synonym: pyrexia

conditioned taste aversion
type: Class
subclass of: GO_0007631
subclass of: GO_0008306
IAO_0000115: A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus.

behavioral fear response
type: Class
subclass of: behavioral defense response
subclass of: GO_0042596
IAO_0000115: An acute behavioral change resulting from a perceived external threat.
has exact synonym: behavioural fear response

G protein-coupled receptor binding
type: Class
subclass of: GO_0005102
IAO_0000115: Binding to a G protein-coupled receptor.
has exact synonym: G protein coupled receptor binding
has exact synonym: G-protein coupled receptor binding
has related synonym: G protein coupled receptor ligand
has related synonym: G-protein-coupled receptor ligand

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
type: Class
subclass of: GO_0008373
IAO_0000115: Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein.
has related synonym: CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase activity
has related synonym: GalNAc alpha-2,6-sialyltransferase I activity

response to hypoxia
type: Class
subclass of: GO_0006950
subclass of: GO_0036293
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
has exact synonym: response to hypoxic stress
has related synonym: response to intermittent hypoxia
has exact synonym: response to lowered oxygen tension
has related synonym: response to sustained hypoxia

ameboidal-type cell migration
type: Class
subclass of: GO_0016477
IAO_0000115: Cell migration that is accomplished by extension and retraction of a pseudopodium.
has exact synonym: ameboid cell migration
has exact synonym: amoeboidal cell migration
has exact synonym: amoeboid cell migration

acrosomal vesicle
type: Class
subclass of: GO_0030141
IAO_0000115: A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
has exact synonym: acrosomal granule
has exact synonym: acrosome

ATPase activator activity
type: Class
subclass of: GO_0140677
IAO_0000115: Binds to and increases the activity of an ATP hydrolysis activity.
has exact synonym: ATPase stimulator activity

male germ cell nucleus
type: Class
subclass of: GO_0043073
IAO_0000115: The nucleus of a male germ cell, a reproductive cell in males.
has exact synonym: male germ-cell nucleus
replaces: GO_0043081

female germ cell nucleus
type: Class
subclass of: GO_0043073
IAO_0000115: The nucleus of the female germ cell, a reproductive cell in females.
has exact synonym: female germ-cell nucleus
replaces: GO_0043080

acrosome assembly
type: Class
subclass of: developmental process involved in reproduction
subclass of: GO_0010927
subclass of: GO_0022412
subclass of: GO_0033363
subclass of: GO_0070925
subclass of: part-of-parent-7286
IAO_0000115: The formation of the acrosome from the spermatid Golgi.
has exact synonym: acrosome formation

long-chain fatty acid metabolic process
type: Class
subclass of: GO_0006631
IAO_0000115: The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
has exact synonym: long-chain fatty acid metabolism

formation of translation initiation ternary complex
type: Class
subclass of: GO_0022618
subclass of: part-of-parent-6413
IAO_0000115: Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator).
has exact synonym: translation initiation ternary complex assembly

cellular glucose homeostasis
type: Class
subclass of: GO_0042593
subclass of: GO_0055082
IAO_0000115: A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment.
has exact synonym: cell glucose homeostasis

tRNA 3'-terminal CCA addition
type: Class
subclass of: GO_0042780
IAO_0000115: Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript. CCA addition proceeds by the sequential addition of CTP, CTP, and then ATP to the 3' end of the tRNA, yielding a diphosphate with each nucleotide addition.
has related synonym: ATP(CTP):tRNA nucleotidyltransferase activity
has related synonym: ATP(CTP)-tRNA nucleotidyltransferase activity
has related synonym: CCA-adding enzyme, tRNA adenylyltransferase, tRNA cytidylyltransferase, tRNA CCA-pyrophosphorylase activity
has related synonym: CCA-adding enzyme activity
has related synonym: -C-C-A pyrophosphorylase activity
has related synonym: CCA tRNA nucleotidyltransferase activity
has related synonym: CTP:tRNA cytidylyltransferase activity
has related synonym: CTP(ATP):tRNA nucleotidyltransferase activity
has related synonym: ribonucleic cytidylic cytidylic adenylic pyrophosphorylase activity
has related synonym: ribonucleic cytidylyltransferase activity
has related synonym: transfer ribonucleate adenyltransferase activity
has related synonym: transfer ribonucleate adenylyltransferase activity
has related synonym: transfer ribonucleate cytidylyltransferase activity
has related synonym: transfer ribonucleate nucleotidyltransferase activity
has related synonym: transfer ribonucleic acid nucleotidyl transferase activity
has related synonym: transfer ribonucleic adenylyl (cytidylyl) transferase activity
has related synonym: transfer ribonucleic-terminal trinucleotide nucleotidyltransferase activity
has related synonym: transfer RNA adenylyltransferase activity
has related synonym: transfer-RNA nucleotidyltransferase activity
has related synonym: tRNA adenylyl(cytidylyl)transferase activity
has related synonym: tRNA CCA-diphosphorylase activity
has related synonym: tRNA cytidylyltransferase activity
has related synonym: tRNA-nucleotidyltransferase activity

sialate O-acetylesterase activity
type: Class
subclass of: GO_0008126
IAO_0000115: Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate.
has related synonym: N-acetylneuraminate acetyltransferase activity
has related synonym: N-acyl-O-acetylneuraminate O-acetylhydrolase activity
has exact synonym: sialate 9(4)-O-acetylesterase activity

tRNA 5'-leader removal
type: Class
subclass of: GO_0099116
IAO_0000115: Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P.
has exact synonym: tRNA 5' leader removal

obsolete axonemal dynein heavy chain
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete axonemal dynein intermediate chain
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete axonemal dynein intermediate light chain
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete axonemal dynein light chain
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete cytoplasmic dynein heavy chain
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete cytoplasmic dynein intermediate chain
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete cytoplasmic dynein intermediate light chain
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete cytoplasmic dynein light chain
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

pseudophosphatase activity
type: Class
subclass of: GO_0019212
IAO_0000115: Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues.

histamine metabolic process
type: Class
subclass of: GO_0006576
subclass of: GO_0052803
subclass of: GO_0097164
IAO_0000115: The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
has exact synonym: histamine metabolism

histamine biosynthetic process
type: Class
subclass of: histamine metabolic process
subclass of: GO_0018130
subclass of: GO_0019438
subclass of: GO_0042401
subclass of: GO_1901362
IAO_0000115: The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
has exact synonym: histamine anabolism
has exact synonym: histamine biosynthesis
has exact synonym: histamine formation
has exact synonym: histamine synthesis
replaces: GO_0001693

histamine catabolic process
type: Class
subclass of: histamine metabolic process
subclass of: GO_0042135
subclass of: GO_0042402
subclass of: GO_0052805
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
has exact synonym: histamine breakdown
has exact synonym: histamine catabolism
has exact synonym: histamine degradation

gastric acid secretion
type: Class
subclass of: GO_0022600
subclass of: GO_0046717
IAO_0000115: The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.
has related synonym: hydrochloric acid secretion

histamine-induced gastric acid secretion
type: Class
subclass of: gastric acid secretion
IAO_0000115: The regulated release of gastric acid induced by the interaction of histamine with H2 type receptor receptors with subsequent activation of adenylate cyclase and elevation of intracellular cyclic AMP.

gastrin-induced gastric acid secretion
type: Class
subclass of: gastric acid secretion
IAO_0000115: The regulated release of gastric acid induced by the interaction of gastrin with its receptor.

acetylcholine-induced gastric acid secretion
type: Class
subclass of: gastric acid secretion
subclass of: part-of-parent-1905145
IAO_0000115: The regulated release of gastric acid by parietal cells in response to acetylcholine.

embryonic development via the syncytial blastoderm
type: Class
subclass of: GO_0009792
IAO_0000115: The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster.

in utero embryonic development
type: Class
subclass of: GO_0043009
IAO_0000115: The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.

gastrulation with mouth forming second
type: Class
subclass of: GO_0007369
IAO_0000115: A gastrulation process in which the initial invagination becomes the anus and the mouth forms second.
has exact synonym: deuterostomic gastrulation
replaces: GO_0010003
replaces: GO_0048276

gastrulation with mouth forming first
type: Class
subclass of: GO_0007369
IAO_0000115: A gastrulation process in which the initial invagination becomes the mouth and the anus forms second.
has related synonym: protostomic gastrulation

formation of primary germ layer
type: Class
subclass of: GO_0048646
subclass of: part-of-parent-7369
IAO_0000115: The formation of the ectoderm, mesoderm and endoderm during gastrulation.

ectoderm formation
type: Class
subclass of: formation of primary germ layer
subclass of: part-of-parent-7398
IAO_0000115: The formation of ectoderm during gastrulation.

endoderm formation
type: Class
subclass of: formation of primary germ layer
subclass of: part-of-parent-7492
IAO_0000115: The formation of the endoderm during gastrulation.
has related synonym: endoblast formation

mesoderm formation
type: Class
subclass of: formation of primary germ layer
subclass of: part-of-parent-48332
IAO_0000115: The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.

cell fate specification
type: Class
subclass of: GO_0048869
subclass of: part-of-parent-45165
IAO_0000115: The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.

cell fate determination
type: Class
subclass of: GO_0048869
subclass of: part-of-parent-45165
IAO_0000115: A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment.

mesodermal cell fate commitment
type: Class
subclass of: GO_0060795
subclass of: part-of-parent-48333
IAO_0000115: The cell differentiation process that results in commitment of a cell to become part of the mesoderm.
has exact synonym: mesoderm cell fate commitment

endodermal cell fate commitment
type: Class
subclass of: GO_0060795
subclass of: part-of-parent-35987
IAO_0000115: The cell differentiation process that results in commitment of a cell to become part of the endoderm.
has exact synonym: endoderm cell fate commitment

ectodermal cell fate commitment
type: Class
subclass of: GO_0060795
subclass of: part-of-parent-1705
subclass of: part-of-parent-10668
IAO_0000115: The cell differentiation process that results in commitment of a cell to become part of the ectoderm.
has exact synonym: ectoderm cell fate commitment

ectodermal cell fate determination
type: Class
subclass of: cell fate determination
subclass of: part-of-parent-1712
IAO_0000115: The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an ectoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed.
has exact synonym: ectoderm cell fate determination

endodermal cell fate specification
type: Class
subclass of: cell fate specification
subclass of: part-of-parent-1711
IAO_0000115: The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
has exact synonym: endoderm cell fate specification

ectodermal cell fate specification
type: Class
subclass of: cell fate specification
subclass of: part-of-parent-1712
IAO_0000115: The cell fate determination process that results in a cell becoming becomes capable of differentiating autonomously into an ectoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
has exact synonym: ectoderm cell fate specification

L-amino-acid oxidase activity
type: Class
subclass of: GO_0016641
IAO_0000115: Catalysis of the reaction: a L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide.
has related synonym: L-amino-acid:oxygen oxidoreductase (deaminating)
has related synonym: ophio-amino-acid oxidase activity

conversion of seryl-tRNAsec to selenocys-tRNAsec
type: Class
subclass of: GO_0019988
IAO_0000115: The modification process that results in the conversion of serine, carried by a specialized tRNA(ser) (which can read a UGA anticodon), to selenocysteine.

conversion of lysyl-tRNA to pyrrolysyl-tRNA
type: Class
subclass of: GO_0019988
IAO_0000115: The modification process that results in the conversion of lysine, carried by a specialized lysine-accepting tRNA (possessing a CUA anticodon), to pyrrolysine (a lysine with an amide linkage to a (4R,5R)-4-substituted pyrroline-5-carboxylate).

obsolete intermediate filament associated protein
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Proteins that associate with intermediate filaments and function in the supramolecular organization of cellular intermediate filament networks.

obsolete type I intermediate filament associated protein
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Low molecular weight (10-45 kDa) proteins that associate with intermediate filaments by lateral binding of the filaments and have the effect of creating tight macrofilament aggregates.

obsolete type II intermediate filament associated protein
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. High molecular weight (100-300 kDa) proteins that associate with intermediate filaments to cross-link them into loose networks.

obsolete type III intermediate filament associated protein
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Proteins that associate with the ends of intermediate filaments and couple the intermediate filaments to the plasma membrane.

stress fiber
type: Class
subclass of: GO_0042641
subclass of: GO_0097517
IAO_0000115: A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
has related synonym: actin cable
has exact synonym: stress fibre

ruffle
type: Class
subclass of: GO_0120025
subclass of: part-of-parent-31252
IAO_0000115: Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
has related synonym: membrane ruffle

lipid kinase activity
type: Class
subclass of: GO_0016301
subclass of: part-of-parent-46834
IAO_0000115: Catalysis of the phosphorylation of a simple or complex lipid.

ceramide kinase activity
type: Class
subclass of: lipid kinase activity
IAO_0000115: Catalysis of the reaction: ATP + ceramide = ADP + ceramide-1-phosphate.
has related synonym: acylsphingosine kinase activity
has related synonym: ATP:ceramide 1-phosphotransferase activity

2'-5'-oligoadenylate synthetase activity
type: Class
subclass of: GO_0070566
IAO_0000115: Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA.
has exact synonym: (2-5')oligo(A) synthetase activity
has exact synonym: 2'-5' oligoadenylate synthetase activity
has exact synonym: 2-5A synthetase activity
has exact synonym: oligo-2',5'-adenylate synthetase activity

formation of translation preinitiation complex
type: Class
subclass of: GO_0022618
subclass of: part-of-parent-2183
IAO_0000115: The joining of the small ribosomal subunit, ternary complex, and mRNA.
has exact synonym: formation of translation pre-initiation complex
has exact synonym: translation preinitiation complex assembly

formation of cytoplasmic translation initiation complex
type: Class
subclass of: GO_0022618
subclass of: part-of-parent-2183
IAO_0000115: Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.
has exact synonym: cytoplasmic translation initiation complex assembly
has related synonym: formation of translation initiation complex
has related synonym: translation initiation complex assembly

galactosylceramide sulfotransferase activity
type: Class
subclass of: GO_0050694
IAO_0000115: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate.
has related synonym: 3'-phosphoadenosine-5'-phosphosulfate-cerebroside sulfotransferase activity
has related synonym: 3'-phosphoadenylyl-sulfate:galactosylceramide 3'-sulfotransferase activity
has exact synonym: cerebroside sulfotransferase activity
has related synonym: galactocerebroside sulfotransferase activity
has related synonym: galactolipid sulfotransferase activity
has exact synonym: galactosylceramide sulphotransferase activity
has related synonym: glycolipid sulfotransferase activity
has related synonym: glycosphingolipid sulfotransferase activity
has related synonym: GSase

mRNA (N6-adenosine)-methyltransferase activity
type: Class
subclass of: GO_0008174
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + RRACH = S-adenosyl-L-homocysteine + RRm6ACH; R is a purine, and H is C, A, or U.

prenylcysteine oxidase activity
type: Class
subclass of: GO_0016670
IAO_0000115: Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2.
has related synonym: prenylcysteine lyase activity
has related synonym: S-prenyl-L-cysteine:oxygen oxidoreductase activity

establishment of planar polarity
type: Class
subclass of: GO_0007164
subclass of: part-of-parent-1738
IAO_0000115: Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates.
has related synonym: establishment of planar cell polarity

establishment of imaginal disc-derived wing hair orientation
type: Class
subclass of: establishment of planar polarity
subclass of: GO_0009886
subclass of: part-of-parent-35317
IAO_0000115: Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction.
has exact synonym: establishment of wing hair orientation

morphogenesis of a polarized epithelium
type: Class
subclass of: morphogenesis of an epithelium
IAO_0000115: The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis.
has exact synonym: epithelial polarization

sex chromatin
type: Class
subclass of: heterochromatin
subclass of: part-of-parent-803
IAO_0000115: Chromatin that is part of a sex chromosome.

Barr body
type: Class
subclass of: nuclear chromosome
subclass of: X chromosome
IAO_0000115: A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery.

XY body
type: Class
subclass of: sex chromosome
IAO_0000115: A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery.

oenocyte differentiation
type: Class
subclass of: GO_0030154
IAO_0000115: The process in which a relatively unspecialized cell acquires the specialized features of an oenocyte. Oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments.
has exact synonym: oenocyte cell differentiation

lens placode formation
type: Class
subclass of: GO_0060788
subclass of: part-of-parent-48598
IAO_0000115: The initial developmental process that will lead to the formation of an eye.
has related synonym: optic placode formation

insect visual primordium formation
type: Class
subclass of: GO_0060788
subclass of: part-of-parent-1748
IAO_0000115: Establishment of the optic lobe placode. In Drosophila, for example, the placode appears in the dorsolateral region of the head in late stage 11 embryos and is the precursor to the larval visual system.
has exact synonym: optic lobe and Bolwig's organ precursor formation
has exact synonym: optic lobe placode formation
replaces: GO_0007457

compound eye morphogenesis
type: Class
subclass of: GO_0048592
subclass of: part-of-parent-48749
IAO_0000115: The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
has exact synonym: insect-type retina morphogenesis

Bolwig's organ morphogenesis
type: Class
subclass of: GO_0048592
subclass of: part-of-parent-55034
IAO_0000115: The morphogenetic process in which the anatomical structures of the larval eye in Drosophila are generated and organized. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain.

insect visual primordium development
type: Class
subclass of: GO_0048856
IAO_0000115: The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. An example of this process is found in Drosophila melanogaster.
has exact synonym: optic lobe and Bolwig's organ precursor development
has exact synonym: optic lobe placode development
has related synonym: optic placode development
replaces: GO_0048049

photoreceptor outer segment
type: Class
subclass of: GO_0110165
subclass of: part-of-parent-97733
IAO_0000115: The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.

compound eye photoreceptor cell differentiation
type: Class
subclass of: eye photoreceptor cell differentiation
subclass of: part-of-parent-1745
IAO_0000115: The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell.

compound eye photoreceptor fate commitment
type: Class
subclass of: GO_0042706
subclass of: part-of-parent-1751
IAO_0000115: The process in which the developmental fate of a cell becomes restricted such that it will develop into a compound eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments.
replaces: GO_0007459

obsolete adult eye photoreceptor development (sensu Drosophila)
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Development of a photoreceptor, a receptor that responds to light, in the adult Drosophila eye.

eye photoreceptor cell differentiation
type: Class
subclass of: GO_0046530
subclass of: part-of-parent-48592
IAO_0000115: The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms.

neural crest cell migration
type: Class
subclass of: GO_0090497
subclass of: part-of-parent-14032
IAO_0000115: The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.

somitogenesis
type: Class
subclass of: GO_0009952
subclass of: GO_0035282
subclass of: GO_0048646
subclass of: part-of-parent-43009
subclass of: part-of-parent-61053
IAO_0000115: The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
has exact synonym: formation of mesodermal clusters

somite specification
type: Class
subclass of: GO_0007379
subclass of: GO_0009880
subclass of: part-of-parent-1756
IAO_0000115: The process in which individual somites establish identity during embryogenesis.

retinal dehydrogenase activity
type: Class
subclass of: GO_0016620
IAO_0000115: Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal.
has related synonym: cytosolic retinal dehydrogenase activity
has related synonym: retinal:NAD+ oxidoreductase activity

organ induction
type: Class
subclass of: regulation of animal organ formation
subclass of: GO_0031128
subclass of: GO_0110110
IAO_0000115: The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ.
has exact synonym: induction of an organ

aminocarboxymuconate-semialdehyde decarboxylase activity
type: Class
subclass of: GO_0016831
IAO_0000115: Catalysis of the reaction: 2-amino-3-carboxymuconate 6-semialdehyde + H(+) = 2-aminomuconate 6-semialdehyde + CO(2).
has related synonym: 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase (2-aminomuconate-semialdehyde-forming)
has related synonym: 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase activity
has related synonym: 2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase activity
has exact synonym: ACMSD activity
has related synonym: alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase activity
has related synonym: alpha-amino-beta-carboxymuconate-epsilon-semialdehyde beta-decarboxylase activity
has related synonym: picolinic acid carboxylase activity
has related synonym: picolinic acid decarboxylase activity

beta-alanine transmembrane transporter activity
type: Class
subclass of: GO_0008514
subclass of: GO_0015175
subclass of: part-of-parent-1762
IAO_0000115: Enables the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid.
has related synonym: beta-alanine transporter activity

beta-alanine transport
type: Class
subclass of: GO_0015804
subclass of: GO_0046942
IAO_0000115: The directed movement of beta-alanine, 3-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

morphogenesis of a branching structure
type: Class
subclass of: GO_0009653
subclass of: GO_0032501
IAO_0000115: The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes.
has exact synonym: branching morphogenesis

neuron migration
type: Class
subclass of: GO_0016477
subclass of: part-of-parent-48699
IAO_0000115: The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
has exact synonym: neuronal migration
has exact synonym: neuron chemotaxis
has related synonym: neuron guidance

membrane raft assembly
type: Class
subclass of: GO_0031579
subclass of: GO_0071709
IAO_0000115: The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes.
has exact synonym: lipid raft assembly
has related synonym: lipid raft formation
has related synonym: membrane raft formation

membrane raft polarization
type: Class
subclass of: GO_0031580
IAO_0000115: The clustering and aggregation of a membrane into domains. This serves as a mechanism to compartmentalize cellular activities and to establish cell polarity.
has exact synonym: lipid raft polarization
has exact synonym: membrane polarization

establishment of lymphocyte polarity
type: Class
subclass of: GO_0030010
subclass of: part-of-parent-46649
IAO_0000115: The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell.
has exact synonym: lymphocyte polarization

establishment of T cell polarity
type: Class
subclass of: establishment of lymphocyte polarity
subclass of: part-of-parent-42110
IAO_0000115: The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell.
has exact synonym: establishment of T-cell polarity
has exact synonym: establishment of T lymphocyte polarity
has exact synonym: establishment of T-lymphocyte polarity
has exact synonym: T cell polarization
has exact synonym: T-cell polarization
has exact synonym: T lymphocyte polarization

establishment of B cell polarity
type: Class
subclass of: establishment of lymphocyte polarity
subclass of: part-of-parent-42113
IAO_0000115: The directed orientation of B cell signaling molecules and associated membrane rafts towards a chemokine gradient of a contact point with an antigen displaying cell.
has exact synonym: B cell polarization
has exact synonym: B-cell polarization
has exact synonym: B lymphocyte polarization
has exact synonym: establishment of B-cell polarity
has exact synonym: establishment of B lymphocyte polarity
has exact synonym: establishment of B-lymphocyte polarity

establishment of natural killer cell polarity
type: Class
subclass of: establishment of lymphocyte polarity
subclass of: part-of-parent-30101
IAO_0000115: The directed orientation of natural killer cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with a cell displaying natural killer cell activating ligands.
has exact synonym: establishment of NK cell polarity
has exact synonym: natural killer cell polarization
has exact synonym: NK cell polarization

immunological synapse formation
type: Class
subclass of: GO_0009988
subclass of: part-of-parent-46649
IAO_0000115: The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
has exact synonym: formation of immunological synapse

immunological synapse
type: Class
subclass of: GO_0110165
subclass of: part-of-parent-5886
IAO_0000115: An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
has related synonym: c-SMAC
has exact synonym: supramolecular activation cluster

myeloid dendritic cell activation
type: Class
subclass of: myeloid leukocyte activation
IAO_0000115: The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.

microglial cell activation
type: Class
subclass of: leukocyte activation involved in inflammatory response
subclass of: GO_0042116
subclass of: GO_0061900
IAO_0000115: The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.

cell activation
type: Class
subclass of: GO_0009987
IAO_0000115: A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.

leukocyte homeostasis
type: Class
subclass of: immune system process
subclass of: GO_0048872
IAO_0000115: The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus.
has exact synonym: immune cell homeostasis
has exact synonym: leucocyte homeostasis

T cell homeostatic proliferation
type: Class
subclass of: GO_0042098
subclass of: part-of-parent-42592
subclass of: part-of-parent-43029
IAO_0000115: The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus.
has exact synonym: resting T cell proliferation
has exact synonym: resting T-cell proliferation
has exact synonym: T-cell homeostatic proliferation
has exact synonym: T lymphocyte homeostatic proliferation
has exact synonym: T-lymphocyte homeostatic proliferation

plasma membrane repair
type: Class
subclass of: GO_0007009
subclass of: part-of-parent-42060
IAO_0000115: The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress.

natural killer cell differentiation
type: Class
subclass of: GO_0030098
subclass of: GO_0030101
IAO_0000115: The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell.
has related synonym: natural killer cell development
has exact synonym: NK cell differentiation

neutrophil homeostasis
type: Class
subclass of: leukocyte homeostasis
subclass of: myeloid cell homeostasis
IAO_0000115: The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus.

neutrophil apoptotic process
type: Class
subclass of: GO_0006925
subclass of: GO_0033028
subclass of: GO_0071887
subclass of: part-of-parent-1780
IAO_0000115: Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
has exact synonym: apoptosis of neutrophils
has related synonym: neutrophil apoptosis
has exact synonym: neutrophil programmed cell death by apoptosis
has exact synonym: programmed cell death, neutrophils
has exact synonym: programmed cell death of neutrophils by apoptosis

B cell homeostasis
type: Class
subclass of: lymphocyte homeostasis
IAO_0000115: The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
has exact synonym: B-cell homeostasis
has exact synonym: B lymphocyte homeostasis
has exact synonym: B-lymphocyte homeostasis

B cell apoptotic process
type: Class
subclass of: GO_0070227
IAO_0000115: Any apoptotic process in a B cell, a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
has exact synonym: apoptosis of B cells
has exact synonym: apoptosis of B-cells
has exact synonym: apoptosis of B lymphocytes
has exact synonym: apoptosis of B-lymphocytes
has related synonym: B cell apoptosis
has exact synonym: B-cell apoptosis
has exact synonym: B cell programmed cell death by apoptosis
has exact synonym: B-cell programmed cell death by apoptosis
has exact synonym: B lymphocyte apoptosis
has exact synonym: B-lymphocyte apoptosis
has exact synonym: B lymphocyte programmed cell death by apoptosis
has exact synonym: B-lymphocyte programmed cell death by apoptosis
has exact synonym: programmed cell death, B cells
has exact synonym: programmed cell death, B-cells
has exact synonym: programmed cell death, B lymphocytes
has exact synonym: programmed cell death, B-lymphocytes
has exact synonym: programmed cell death of B cells by apoptosis
has exact synonym: programmed cell death of B-cells by apoptosis
has exact synonym: programmed cell death of B lymphocytes by apoptosis
has exact synonym: programmed cell death of B-lymphocytes by apoptosis

phosphotyrosine residue binding
type: Class
subclass of: GO_0045309
IAO_0000115: Binding to a phosphorylated tyrosine residue within a protein.
has related synonym: phosphotyrosine binding

prostaglandin J receptor activity
type: Class
subclass of: GO_0004955
IAO_0000115: Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity.
has exact synonym: PGJ(2) receptor activity
has related synonym: PGJ receptor activity

phosphatidylserine binding
type: Class
subclass of: GO_0005543
subclass of: GO_0072341
IAO_0000115: Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.

natural killer cell proliferation
type: Class
subclass of: GO_0030101
subclass of: GO_0046651
IAO_0000115: The expansion of a natural killer cell population by cell division.
has exact synonym: NK cell proliferation

antibody-dependent cellular cytotoxicity
type: Class
subclass of: type IIa hypersensitivity
subclass of: leukocyte mediated cytotoxicity
IAO_0000115: Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells.
has exact synonym: ADCC
has exact synonym: antibody dependent cell death
has exact synonym: antibody-dependent cell death
has exact synonym: antibody dependent cell killing
has exact synonym: antibody-dependent cell killing
has exact synonym: type VI hypersensitivity

polymeric immunoglobulin binding
type: Class
subclass of: GO_0019865
IAO_0000115: Binding to a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes.

IgM binding
type: Class
subclass of: GO_0019865
IAO_0000115: Binding to an immunoglobulin of the IgM isotype.

polymeric immunoglobulin receptor activity
type: Class
subclass of: GO_0019763
IAO_0000115: Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

IgM receptor activity
type: Class
subclass of: GO_0019763
IAO_0000115: Combining with an immunoglobulin of the IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

type IIa hypersensitivity
type: Class
subclass of: type II hypersensitivity
IAO_0000115: An inflammatory response resulting in cell death mediated by activation of the classical complement pathway or induction of effector cell phagocytosis or cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell.

type IIb hypersensitivity
type: Class
subclass of: type II hypersensitivity
IAO_0000115: An inflammatory response resulting in cell death or dysfunction mediated by the direct binding of antibody to cellular receptors.
has exact synonym: type V hypersensitivity

regulation of type IIa hypersensitivity
type: Class
subclass of: regulation of type II hypersensitivity
IAO_0000115: Any process that modulates the frequency, rate, or extent of type IIa hypersensitivity, a type of inflammatory response.

negative regulation of type IIa hypersensitivity
type: Class
subclass of: regulation of type IIa hypersensitivity
subclass of: negative regulation of type II hypersensitivity
IAO_0000115: Any process that stops, prevents, or reduces the rate of type IIa hypersensitivity, a type of inflammatory response.
has exact synonym: downregulation of type IIa hypersensitivity
has exact synonym: down regulation of type IIa hypersensitivity
has exact synonym: down-regulation of type IIa hypersensitivity
has related synonym: inhibition of type IIa hypersensitivity

positive regulation of type IIa hypersensitivity
type: Class
subclass of: regulation of type IIa hypersensitivity
subclass of: positive regulation of type II hypersensitivity
IAO_0000115: Any process that activates or increases the frequency, rate or extent of type IIa hypersensitivity, a type of inflammatory response.
has related synonym: activation of type IIa hypersensitivity
has related synonym: stimulation of type IIa hypersensitivity
has exact synonym: upregulation of type IIa hypersensitivity
has exact synonym: up regulation of type IIa hypersensitivity
has exact synonym: up-regulation of type IIa hypersensitivity

regulation of type IIb hypersensitivity
type: Class
subclass of: regulation of type II hypersensitivity
IAO_0000115: Any process that modulates the frequency, rate, or extent of type IIb hypersensitivity, a type of inflammatory response.

negative regulation of type IIb hypersensitivity
type: Class
subclass of: regulation of type IIb hypersensitivity
subclass of: negative regulation of type II hypersensitivity
IAO_0000115: Any process that stops, prevents, or reduces the rate of type IIb hypersensitivity, a type of inflammatory response.
has exact synonym: downregulation of type IIb hypersensitivity
has exact synonym: down regulation of type IIb hypersensitivity
has exact synonym: down-regulation of type IIb hypersensitivity
has related synonym: inhibition of type IIb hypersensitivity

positive regulation of type IIb hypersensitivity
type: Class
subclass of: regulation of type IIb hypersensitivity
subclass of: positive regulation of type II hypersensitivity
IAO_0000115: Any process that activates or increases the frequency, rate or extent of type IIb hypersensitivity, a type of inflammatory response.
has related synonym: activation of type IIb hypersensitivity
has related synonym: stimulation of type IIb hypersensitivity
has exact synonym: upregulation of type IIb hypersensitivity
has exact synonym: up regulation of type IIb hypersensitivity
has exact synonym: up-regulation of type IIb hypersensitivity

type III hypersensitivity
type: Class
subclass of: myeloid leukocyte mediated immunity
subclass of: hypersensitivity
subclass of: GO_0016064
IAO_0000115: An inflammatory response resulting from recognition of immune complexes via complement or Fc receptors on effector cells leading to activation of neutrophils and other leukocytes and damage to bystander tissue.

regulation of type III hypersensitivity
type: Class
subclass of: regulation of hypersensitivity
subclass of: regulation of myeloid leukocyte mediated immunity
subclass of: regulation of immunoglobulin mediated immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of type III hypersensitivity, a type of inflammatory response.

negative regulation of type III hypersensitivity
type: Class
subclass of: regulation of type III hypersensitivity
subclass of: negative regulation of hypersensitivity
subclass of: negative regulation of myeloid leukocyte mediated immunity
subclass of: negative regulation of immunoglobulin mediated immune response
IAO_0000115: Any process that stops, prevents, or reduces the rate of type III hypersensitivity, a type of inflammatory response.
has exact synonym: downregulation of type III hypersensitivity
has exact synonym: down regulation of type III hypersensitivity
has exact synonym: down-regulation of type III hypersensitivity
has related synonym: inhibition of type III hypersensitivity

positive regulation of type III hypersensitivity
type: Class
subclass of: regulation of type III hypersensitivity
subclass of: positive regulation of hypersensitivity
subclass of: positive regulation of myeloid leukocyte mediated immunity
subclass of: positive regulation of immunoglobulin mediated immune response
IAO_0000115: Any process that activates or increases the frequency, rate or extent of type III hypersensitivity, a type of inflammatory response.
has related synonym: activation of type III hypersensitivity
has related synonym: stimulation of type III hypersensitivity
has exact synonym: upregulation of type III hypersensitivity
has exact synonym: up regulation of type III hypersensitivity
has exact synonym: up-regulation of type III hypersensitivity

type IV hypersensitivity
type: Class
subclass of: T cell mediated immunity
subclass of: hypersensitivity
IAO_0000115: An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation.
has exact synonym: delayed hypersensitivity response
has exact synonym: delayed-type hypersensitivity
replaces: GO_0016069

regulation of type IV hypersensitivity
type: Class
subclass of: regulation of T cell mediated immunity
subclass of: regulation of hypersensitivity
IAO_0000115: Any process that modulates the frequency, rate, or extent of type IV hypersensitivity, a type of inflammatory response.

negative regulation of type IV hypersensitivity
type: Class
subclass of: regulation of type IV hypersensitivity
subclass of: negative regulation of T cell mediated immunity
subclass of: negative regulation of hypersensitivity
IAO_0000115: Any process that stops, prevents, or reduces the rate of type IV hypersensitivity, a type of inflammatory response.
has exact synonym: downregulation of type IV hypersensitivity
has exact synonym: down regulation of type IV hypersensitivity
has exact synonym: down-regulation of type IV hypersensitivity
has related synonym: inhibition of type IV hypersensitivity

positive regulation of type IV hypersensitivity
type: Class
subclass of: regulation of type IV hypersensitivity
subclass of: positive regulation of T cell mediated immunity
subclass of: positive regulation of hypersensitivity
IAO_0000115: Any process that activates or increases the frequency, rate or extent of type IV hypersensitivity, a type of inflammatory response.
has related synonym: activation of type IV hypersensitivity
has related synonym: stimulation of type IV hypersensitivity
has exact synonym: upregulation of type IV hypersensitivity
has exact synonym: up regulation of type IV hypersensitivity
has exact synonym: up-regulation of type IV hypersensitivity

regulation of type I hypersensitivity
type: Class
subclass of: regulation of hypersensitivity
subclass of: regulation of immunoglobulin mediated immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of type I hypersensitivity, a type of inflammatory response.

negative regulation of type I hypersensitivity
type: Class
subclass of: regulation of type I hypersensitivity
subclass of: negative regulation of hypersensitivity
subclass of: negative regulation of immunoglobulin mediated immune response
IAO_0000115: Any process that stops, prevents, or reduces the rate of type I hypersensitivity, a type of inflammatory response.
has exact synonym: downregulation of type I hypersensitivity
has exact synonym: down regulation of type I hypersensitivity
has exact synonym: down-regulation of type I hypersensitivity
has related synonym: inhibition of type I hypersensitivity

positive regulation of type I hypersensitivity
type: Class
subclass of: regulation of type I hypersensitivity
subclass of: positive regulation of hypersensitivity
subclass of: positive regulation of immunoglobulin mediated immune response
IAO_0000115: Any process that activates or increases the frequency, rate or extent of type I hypersensitivity, a type of inflammatory response.
has related synonym: activation of type I hypersensitivity
has related synonym: stimulation of type I hypersensitivity
has exact synonym: upregulation of type I hypersensitivity
has exact synonym: up regulation of type I hypersensitivity
has exact synonym: up-regulation of type I hypersensitivity

regulation of antibody-dependent cellular cytotoxicity
type: Class
subclass of: regulation of type IIa hypersensitivity
subclass of: regulation of leukocyte mediated cytotoxicity
IAO_0000115: Any process that modulates the frequency, rate, or extent of antibody-dependent cellular cytotoxicity.
has exact synonym: regulation of antibody dependent cell death
has exact synonym: regulation of antibody-dependent cell death
has exact synonym: regulation of antibody dependent cell killing
has exact synonym: regulation of antibody-dependent cell killing

negative regulation of antibody-dependent cellular cytotoxicity
type: Class
subclass of: negative regulation of type IIa hypersensitivity
subclass of: regulation of antibody-dependent cellular cytotoxicity
subclass of: negative regulation of leukocyte mediated cytotoxicity
IAO_0000115: Any process that stops, prevents, or reduces the rate of antibody-dependent cellular cytotoxicity.
has exact synonym: downregulation of antibody-dependent cellular cytotoxicity
has exact synonym: down regulation of antibody-dependent cellular cytotoxicity
has exact synonym: down-regulation of antibody-dependent cellular cytotoxicity
has related synonym: inhibition of antibody-dependent cellular cytotoxicity
has exact synonym: negative regulation of antibody dependent cell death
has exact synonym: negative regulation of antibody-dependent cell death
has exact synonym: negative regulation of antibody dependent cell killing
has exact synonym: negative regulation of antibody-dependent cell killing

positive regulation of antibody-dependent cellular cytotoxicity
type: Class
subclass of: positive regulation of type IIa hypersensitivity
subclass of: regulation of antibody-dependent cellular cytotoxicity
subclass of: positive regulation of leukocyte mediated cytotoxicity
IAO_0000115: Any process that activates or increases the frequency, rate or extent of antibody-dependent cellular cytotoxicity.
has related synonym: activation of antibody-dependent cellular cytotoxicity
has exact synonym: positive regulation of antibody dependent cell death
has exact synonym: positive regulation of antibody-dependent cell death
has exact synonym: positive regulation of antibody dependent cell killing
has exact synonym: positive regulation of antibody-dependent cell killing
has related synonym: stimulation of antibody-dependent cellular cytotoxicity
has exact synonym: upregulation of antibody-dependent cellular cytotoxicity
has exact synonym: up regulation of antibody-dependent cellular cytotoxicity
has exact synonym: up-regulation of antibody-dependent cellular cytotoxicity

cytokine production
type: Class
subclass of: GO_0010467
subclass of: GO_0032501
IAO_0000115: The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has related synonym: cytokine biosynthetic process
has related synonym: cytokine metabolic process
has related synonym: cytokine secretion
has related synonym: interferon production
has related synonym: interferon secretion
has related synonym: interleukin production
has related synonym: interleukin secretion
replaces: GO_0042032
replaces: GO_0042089
replaces: GO_0042107
replaces: GO_0050663

regulation of cytokine production
type: Class
subclass of: GO_0010468
subclass of: GO_0051239
IAO_0000115: Any process that modulates the frequency, rate, or extent of production of a cytokine.
has exact synonym: regulation of cytokine anabolism
has exact synonym: regulation of cytokine biosynthesis
has related synonym: regulation of cytokine biosynthetic process
has exact synonym: regulation of cytokine formation
has related synonym: regulation of cytokine secretion
has exact synonym: regulation of cytokine synthesis
replaces: GO_0042035
replaces: GO_0050707

negative regulation of cytokine production
type: Class
subclass of: regulation of cytokine production
subclass of: GO_0010629
subclass of: GO_0051241
IAO_0000115: Any process that stops, prevents, or reduces the rate of production of a cytokine.
has exact synonym: downregulation of cytokine biosynthetic process
has exact synonym: down regulation of cytokine biosynthetic process
has exact synonym: down-regulation of cytokine biosynthetic process
has exact synonym: downregulation of cytokine production
has exact synonym: down regulation of cytokine production
has exact synonym: down-regulation of cytokine production
has related synonym: inhibition of cytokine biosynthetic process
has related synonym: inhibition of cytokine production
has exact synonym: negative regulation of cytokine anabolism
has exact synonym: negative regulation of cytokine biosynthesis
has related synonym: negative regulation of cytokine biosynthetic process
has exact synonym: negative regulation of cytokine formation
has related synonym: negative regulation of cytokine secretion
has exact synonym: negative regulation of cytokine synthesis
replaces: GO_0042036
replaces: GO_0050710

positive regulation of cytokine production
type: Class
subclass of: regulation of cytokine production
subclass of: GO_0010628
subclass of: GO_0051240
IAO_0000115: Any process that activates or increases the frequency, rate or extent of production of a cytokine.
has related synonym: activation of cytokine production
has related synonym: positive regulation of cytokine biosynthetic process
has related synonym: positive regulation of cytokine secretion
has related synonym: stimulation of cytokine production
has exact synonym: upregulation of cytokine production
has exact synonym: up regulation of cytokine production
has exact synonym: up-regulation of cytokine production
replaces: GO_0042108
replaces: GO_0050715

serotonin secretion
type: Class
subclass of: GO_0006837
subclass of: GO_0023061
IAO_0000115: The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells.
has exact synonym: 5-HT secretion
has exact synonym: 5-hydroxytryptamine secretion
has related synonym: serotonin release

histamine secretion
type: Class
subclass of: GO_0046903
subclass of: GO_0051608
IAO_0000115: The regulated release of histamine by a cell or tissue. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems.

kidney development
type: Class
subclass of: GO_0048513
subclass of: part-of-parent-72001
IAO_0000115: The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
has related synonym: nephrogenesis

mesonephros development
type: Class
subclass of: kidney development
IAO_0000115: The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney.
has exact synonym: Wolffian body development

blastocyst development
type: Class
subclass of: GO_0048856
subclass of: part-of-parent-1701
IAO_0000115: The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm.

blastocyst formation
type: Class
subclass of: GO_0048646
subclass of: part-of-parent-1824
IAO_0000115: The initial formation of a blastocyst from a solid ball of cells known as a morula.

inner cell mass cell differentiation
type: Class
subclass of: GO_0030154
subclass of: part-of-parent-1825
IAO_0000115: The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell.

inner cell mass cell fate commitment
type: Class
subclass of: GO_0045165
subclass of: part-of-parent-1826
IAO_0000115: The cell fate commitment of precursor cells that will become inner cell mass cells.

inner cell mass cellular morphogenesis
type: Class
subclass of: cell morphogenesis involved in differentiation
subclass of: GO_0048598
subclass of: part-of-parent-1826
IAO_0000115: The morphogenesis of cells in the inner cell mass.

trophectodermal cell differentiation
type: Class
subclass of: GO_0030154
subclass of: part-of-parent-1825
IAO_0000115: The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell.
has exact synonym: trophectoderm cell differentiation

trophectodermal cell fate commitment
type: Class
subclass of: GO_0045165
subclass of: part-of-parent-1829
IAO_0000115: The cell fate commitment of precursor cells that will become trophectoderm cells.
has exact synonym: trophectoderm cell fate commitment

trophectodermal cellular morphogenesis
type: Class
subclass of: cell morphogenesis involved in differentiation
subclass of: GO_0048598
subclass of: part-of-parent-1829
IAO_0000115: The morphogenesis of trophectoderm cells.
has exact synonym: trophectoderm cellular morphogenesis

blastocyst growth
type: Class
subclass of: GO_0048589
subclass of: part-of-parent-1824
IAO_0000115: An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation.

inner cell mass cell proliferation
type: Class
subclass of: GO_0008283
subclass of: part-of-parent-1832
IAO_0000115: The proliferation of cells in the inner cell mass.

trophectodermal cell proliferation
type: Class
subclass of: GO_0008283
subclass of: part-of-parent-1832
IAO_0000115: The proliferation of cells in the trophectoderm.
has exact synonym: trophectoderm cell proliferation

blastocyst hatching
type: Class
subclass of: GO_0035188
subclass of: part-of-parent-1824
IAO_0000115: The hatching of the cellular blastocyst from the zona pellucida.

release of cytochrome c from mitochondria
type: Class
subclass of: GO_0008637
subclass of: part-of-parent-97190
IAO_0000115: The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation.

epithelial to mesenchymal transition
type: Class
subclass of: GO_0048762
IAO_0000115: A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
has exact synonym: EMT
has exact synonym: epithelial-mesenchymal transition
has exact synonym: mesenchymal cell differentiation from epithelial cell

embryonic epithelial tube formation
type: Class
subclass of: GO_0072175
subclass of: part-of-parent-16331
IAO_0000115: The morphogenesis of an embryonic epithelium into a tube-shaped structure.

neural plate morphogenesis
type: Class
subclass of: GO_0016331
subclass of: part-of-parent-1840
IAO_0000115: The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue.

neural plate development
type: Class
subclass of: GO_0060429
subclass of: part-of-parent-43009
IAO_0000115: The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.

neural tube formation
type: Class
subclass of: embryonic epithelial tube formation
subclass of: part-of-parent-21915
IAO_0000115: The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.
has exact synonym: neural tube morphogenesis
has exact synonym: neurulation
replaces: GO_0001679

neural fold formation
type: Class
subclass of: GO_0016331
subclass of: GO_0048646
subclass of: GO_0060571
subclass of: part-of-parent-14020
IAO_0000115: The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove.
has related synonym: neural groove formation

neural tube closure
type: Class
subclass of: GO_0060606
subclass of: part-of-parent-14020
IAO_0000115: The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.

protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
type: Class
subclass of: GO_0051204
subclass of: part-of-parent-97190
subclass of: part-of-parent-97345
IAO_0000115: The process in which a protein is incorporated into a mitochondrial membrane as the initial phase of the mitochondrial membrane permeabilization that takes place in the apoptotic signaling pathway.
has related synonym: insertion of proteins into mitochondrial membranes during the induction of apoptosis
has related synonym: protein insertion into mitochondrial membrane during induction of apoptosis
has related synonym: protein insertion into mitochondrial membrane involved in induction of apoptosis
has related synonym: protein insertion into mitochondrion membrane during induction of apoptosis

phagolysosome assembly
type: Class
subclass of: GO_0007040
subclass of: GO_0016050
subclass of: GO_0070925
subclass of: part-of-parent-6909
subclass of: part-of-parent-90382
IAO_0000115: The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome.
has related synonym: late phagosome biosynthesis
has related synonym: late phagosome formation
has related synonym: phagolysosome formation

opsonin binding
type: Class
subclass of: GO_0005515
IAO_0000115: Binding to an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material.

opsonin receptor activity
type: Class
subclass of: GO_0004888
IAO_0000115: Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

complement binding
type: Class
subclass of: GO_0005515
IAO_0000115: Binding to a component or product of the complement cascade.

complement component C1q complex binding
type: Class
subclass of: opsonin binding
subclass of: complement binding
subclass of: GO_0044877
IAO_0000115: Binding to a C1q complex, a component of the classical complement cascade.

complement component C3a binding
type: Class
subclass of: complement binding
IAO_0000115: Binding to a C3a product of the complement cascade.

complement component C3b binding
type: Class
subclass of: opsonin binding
subclass of: complement binding
IAO_0000115: Binding to a C3b product of the complement cascade.

complement component iC3b binding
type: Class
subclass of: opsonin binding
subclass of: complement binding
IAO_0000115: Binding to a iC3b product of the complement cascade.

complement component C3dg binding
type: Class
subclass of: complement binding
IAO_0000115: Binding to a C3dg product of the complement cascade.

complement component C3d binding
type: Class
subclass of: complement binding
IAO_0000115: Binding to a C3d product of the complement cascade.

complement component C4b binding
type: Class
subclass of: opsonin binding
subclass of: complement binding
IAO_0000115: Binding to a C4b product of the classical complement cascade.

complement component C5a binding
type: Class
subclass of: complement binding
IAO_0000115: Binding to a C5a product of the complement cascade.

complement component C1q receptor activity
type: Class
subclass of: opsonin receptor activity
subclass of: GO_0004875
IAO_0000115: Combining with the C1q complex, a component of the classical complement cascade, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

complement component iC3b receptor activity
type: Class
subclass of: opsonin receptor activity
subclass of: GO_0004875
IAO_0000115: Combining with the iC3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

complement component C3dg receptor activity
type: Class
subclass of: GO_0004875
IAO_0000115: Combining with the C3dg product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

complement component C3d receptor activity
type: Class
subclass of: GO_0004875
IAO_0000115: Combining with the C3d product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

complement component C4b receptor activity
type: Class
subclass of: opsonin receptor activity
subclass of: GO_0004875
IAO_0000115: Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

collectin binding
type: Class
subclass of: opsonin binding
IAO_0000115: Binding to a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus.

collectin receptor activity
type: Class
subclass of: opsonin receptor activity
IAO_0000115: Combining with a collectin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

pentraxin binding
type: Class
subclass of: opsonin binding
IAO_0000115: Binding to a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array.

NK T cell differentiation
type: Class
subclass of: GO_0046632
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a NK T cell.
has exact synonym: natural killer T cell differentiation
has exact synonym: natural T cell differentiation
has related synonym: NK T cell development
has exact synonym: NKT cell differentiation
has exact synonym: NK T-cell differentiation
has exact synonym: NK T lymphocyte differentiation
has exact synonym: NK T-lymphocyte differentiation
has exact synonym: NT cell differentiation

NK T cell proliferation
type: Class
subclass of: GO_0046633
subclass of: GO_0051132
IAO_0000115: The expansion of a NK T cell population by cell division.
has exact synonym: natural killer T cell proliferation
has exact synonym: natural T cell proliferation
has exact synonym: NKT cell proliferation
has exact synonym: NK T-cell proliferation
has exact synonym: NK T lymphocyte proliferation
has exact synonym: NK T-lymphocyte proliferation
has exact synonym: NT cell proliferation

complement activation, lectin pathway
type: Class
subclass of: GO_0006956
subclass of: GO_0045087
IAO_0000115: Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
has exact synonym: complement cascade, lectin pathway

regulation of complement activation, lectin pathway
type: Class
subclass of: GO_0030449
subclass of: GO_0045088
IAO_0000115: Any process that modulates the frequency, rate or extent of the lectin pathway of complement activation.
has exact synonym: regulation of complement cascade, lectin pathway

negative regulation of complement activation, lectin pathway
type: Class
subclass of: regulation of complement activation, lectin pathway
subclass of: GO_0045824
subclass of: GO_0045916
IAO_0000115: Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway.
has exact synonym: downregulation of complement activation, lectin pathway
has exact synonym: down regulation of complement activation, lectin pathway
has exact synonym: down-regulation of complement activation, lectin pathway
has related synonym: inhibition of complement activation, lectin pathway
has exact synonym: negative regulation of complement cascade, lectin pathway

positive regulation of complement activation, lectin pathway
type: Class
subclass of: regulation of complement activation, lectin pathway
subclass of: GO_0045089
subclass of: GO_0045917
IAO_0000115: Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway.
has related synonym: activation of complement activation, lectin pathway
has exact synonym: positive regulation of complement cascade, lectin pathway
has related synonym: stimulation of complement activation, lectin pathway
has exact synonym: upregulation of complement activation, lectin pathway
has exact synonym: up regulation of complement activation, lectin pathway
has exact synonym: up-regulation of complement activation, lectin pathway

obsolete pattern binding
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to a repeating or polymeric structure, such as a polysaccharide or peptidoglycan.

(1->3)-beta-D-glucan binding
type: Class
subclass of: GO_0030247
IAO_0000115: Binding to a (1->3)-beta-D-glucan.
has exact synonym: 1,3-beta-D-glucan binding
has related synonym: callose binding
has related synonym: zymosan binding
replaces: GO_0080087

polysaccharide immune receptor activity
type: Class
subclass of: GO_0038187
IAO_0000115: Combining with a polysaccharide and transmitting the signal to initiate an innate immune response. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.
has related synonym: polysaccharide receptor activity

(1->3)-beta-D-glucan immune receptor activity
type: Class
subclass of: polysaccharide immune receptor activity
IAO_0000115: Combining with (1->3)-beta-D-glucans to initiate an innate immune response.
has exact synonym: (1,3)-beta-D-glucan receptor activity
has related synonym: (1->3)-beta-D-glucan receptor activity
has exact synonym: 1,3-beta-D-glucan receptor activity
has exact synonym: beta-1,3-D-glucan receptor activity
has related synonym: zymosan receptor activity

lipopolysaccharide immune receptor activity
type: Class
subclass of: GO_0038187
subclass of: part-of-parent-31663
IAO_0000115: Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate an innate immune response. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
has related synonym: endotoxin receptor activity
has related synonym: lipopolysaccharide receptor activity
has exact synonym: LPS receptor activity

lipoarabinomannan binding
type: Class
subclass of: GO_0034235
IAO_0000115: Binding to lipoarabinomannan.
has exact synonym: LAM binding

lipoarabinomannan immune receptor activity
type: Class
subclass of: GO_0038187
IAO_0000115: Combining with lipoarabinomannan and transmitting the signal to initiate an innate immune response.
has exact synonym: LAM receptor activity
has related synonym: lipoarabinomannan receptor activity

response to yeast
type: Class
subclass of: GO_0009620
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species.

detection of yeast
type: Class
subclass of: response to yeast
subclass of: GO_0016046
IAO_0000115: The series of events in which a stimulus from a yeast is received and converted into a molecular signal.

Mullerian duct regression
type: Class
subclass of: developmental process involved in reproduction
subclass of: GO_0060033
subclass of: part-of-parent-46661
IAO_0000115: The process in which the Mullerian ducts, primordia of the oviducts, uterus and upper vagina, undergo regression in male embryos.

receptor recycling
type: Class
subclass of: GO_0043112
IAO_0000115: The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal.

nucleoside binding
type: Class
subclass of: GO_0036094
subclass of: GO_0097159
subclass of: GO_0097367
subclass of: GO_1901363
IAO_0000115: Binding to a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose.

purine nucleoside binding
type: Class
subclass of: nucleoside binding
IAO_0000115: Binding to a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose.

pyrimidine nucleoside binding
type: Class
subclass of: nucleoside binding
IAO_0000115: Binding to a pyrimidine nucleoside, a compound consisting of a pyrimidine base linked either to ribose or deoxyribose.

endothelial cell development
type: Class
subclass of: epithelial cell development
subclass of: part-of-parent-45446
IAO_0000115: The progression of an endothelial cell over time, from its formation to the mature structure.

endothelial cell morphogenesis
type: Class
subclass of: epithelial cell morphogenesis
subclass of: part-of-parent-1885
IAO_0000115: The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell.

selenium compound metabolic process
type: Class
subclass of: GO_0044237
IAO_0000115: The chemical reactions and pathways involving compounds that contain selenium, such as selenocysteine.
has exact synonym: selenium compound metabolism
has exact synonym: selenium metabolic process
has exact synonym: selenium metabolism

glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
type: Class
subclass of: GO_0008375
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan.
has related synonym: alpha1,4-N-acetylglucosaminyltransferase activity
has related synonym: alpha-1,4-N-acetylglucosaminyltransferase activity
has related synonym: alpha-N-acetylglucosaminyltransferase I activity
has related synonym: glucuronosylgalactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
has related synonym: UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity
has related synonym: UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity

liver development
type: Class
subclass of: GO_0048732
subclass of: part-of-parent-61008
IAO_0000115: The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.

placenta development
type: Class
subclass of: GO_0048513
IAO_0000115: The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
has exact synonym: placental development
has exact synonym: placentation

phagocytic cup
type: Class
subclass of: GO_0110165
subclass of: part-of-parent-5886
IAO_0000115: An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome.

embryonic placenta development
type: Class
subclass of: GO_0048568
subclass of: part-of-parent-1701
subclass of: part-of-parent-1890
IAO_0000115: The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
has exact synonym: fetal placenta development

maternal placenta development
type: Class
subclass of: developmental process involved in reproduction
subclass of: GO_0048856
subclass of: GO_0060135
subclass of: part-of-parent-1890
IAO_0000115: Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
has related synonym: decidua development

tissue homeostasis
type: Class
subclass of: GO_0060249
subclass of: part-of-parent-48871
IAO_0000115: A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function.
has related synonym: tissue maintenance

retina homeostasis
type: Class
subclass of: tissue homeostasis
IAO_0000115: A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function.

autolysis
type: Class
subclass of: GO_0012501
IAO_0000115: A programmed cell death process observed in bacteria and filamentous fungi and leading to spontaneous death by lysis. Examples are lysis of the mother cell during sporulation of Bacillus subtilis and self-degradation of fungal cells in Aspergillus nidulans. Autolysis is also involved in bacterial biofilm formation.

cytolysis by symbiont of host cells
type: Class
subclass of: killing by symbiont of host cells
IAO_0000115: The killing by an organism of a cell in its host organism by means of the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has exact synonym: cytolysis by organism of host cells
has related synonym: pathogenesis

regulation of cytolysis by symbiont of host cells
type: Class
subclass of: GO_0043903
IAO_0000115: Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has exact synonym: regulation by symbiont of cytolysis of host cells

negative regulation of cytolysis by symbiont of host cells
type: Class
subclass of: regulation of cytolysis by symbiont of host cells
subclass of: GO_0048519
IAO_0000115: Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has exact synonym: downregulation by symbiont of cytolysis of host cells
has exact synonym: down regulation by symbiont of cytolysis of host cells
has exact synonym: down-regulation by symbiont of cytolysis of host cells
has related synonym: inhibition by symbiont of cytolysis of host cells
has exact synonym: negative regulation by symbiont of cytolysis of host cells

positive regulation of cytolysis by symbiont of host cells
type: Class
subclass of: regulation of cytolysis by symbiont of host cells
subclass of: GO_0048518
IAO_0000115: Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has related synonym: activation by symbiont of cytolysis of host cells
has exact synonym: positive regulation by symbiont of cytolysis of host cells
has related synonym: stimulation by symbiont of cytolysis of host cells
has exact synonym: upregulation by symbiont of cytolysis of host cells
has exact synonym: up regulation by symbiont of cytolysis of host cells
has exact synonym: up-regulation by symbiont of cytolysis of host cells

activation of membrane attack complex
type: Class
subclass of: GO_0006956
IAO_0000115: The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis.
has exact synonym: activation of MAC
has related synonym: activation of TCC
has related synonym: activation of terminal complement complex
has related synonym: activation of the terminal complement cascade
has exact synonym: MAC assembly
has exact synonym: MAC formation
has exact synonym: membrane attack complex assembly
has exact synonym: membrane attack complex formation

cell killing
type: Class
subclass of: GO_0009987
IAO_0000115: Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.
has related synonym: necrosis

killing by symbiont of host cells
type: Class
subclass of: GO_0051701
IAO_0000115: Any process mediated by an organism that results in the death of cells in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has related synonym: pathogenesis

leukocyte mediated cytotoxicity
type: Class
subclass of: cell killing
subclass of: leukocyte mediated immunity
IAO_0000115: The directed killing of a target cell by a leukocyte.
has exact synonym: immune cell mediated cell death
has exact synonym: immune cell mediated cell killing
has exact synonym: immune cell mediated cytotoxicity
has exact synonym: leucocyte mediated cytotoxicity

regulation of leukocyte mediated cytotoxicity
type: Class
subclass of: regulation of leukocyte mediated immunity
subclass of: GO_0031341
IAO_0000115: Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity.
has exact synonym: regulation of immune cell mediated cell death
has exact synonym: regulation of immune cell mediated cell killing
has exact synonym: regulation of immune cell mediated cytotoxicity
has exact synonym: regulation of leucocyte mediated cytotoxicity

negative regulation of leukocyte mediated cytotoxicity
type: Class
subclass of: regulation of leukocyte mediated cytotoxicity
subclass of: negative regulation of leukocyte mediated immunity
subclass of: GO_0031342
IAO_0000115: Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity.
has exact synonym: downregulation of leukocyte mediated cytotoxicity
has exact synonym: down regulation of leukocyte mediated cytotoxicity
has exact synonym: down-regulation of leukocyte mediated cytotoxicity
has related synonym: inhibition of leukocyte mediated cytotoxicity
has exact synonym: negative regulation of immune cell mediated cytotoxicity
has exact synonym: negative regulation of leucocyte mediated cytotoxicity

positive regulation of leukocyte mediated cytotoxicity
type: Class
subclass of: regulation of leukocyte mediated cytotoxicity
subclass of: positive regulation of leukocyte mediated immunity
subclass of: GO_0031343
IAO_0000115: Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity.
has related synonym: activation of leukocyte mediated cytotoxicity
has exact synonym: positive regulation of immune cell mediated cytotoxicity
has exact synonym: positive regulation of leucocyte mediated cytotoxicity
has related synonym: stimulation of leukocyte mediated cytotoxicity
has exact synonym: upregulation of leukocyte mediated cytotoxicity
has exact synonym: up regulation of leukocyte mediated cytotoxicity
has exact synonym: up-regulation of leukocyte mediated cytotoxicity

T cell mediated cytotoxicity
type: Class
subclass of: leukocyte mediated cytotoxicity
subclass of: T cell mediated immunity
IAO_0000115: The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
has exact synonym: T cell mediated apoptosis
has exact synonym: T-cell mediated apoptosis
has exact synonym: T cell mediated cell death
has exact synonym: T-cell mediated cell death
has exact synonym: T cell mediated cell killing
has exact synonym: T-cell mediated cell killing
has related synonym: T cell mediated cytolysis
has exact synonym: T-cell mediated cytotoxicity
has exact synonym: T lymphocyte mediated cytotoxicity
has exact synonym: T-lymphocyte mediated cytotoxicity

regulation of T cell mediated cytotoxicity
type: Class
subclass of: regulation of leukocyte mediated cytotoxicity
subclass of: regulation of T cell mediated immunity
IAO_0000115: Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity.
has exact synonym: regulation of T cell mediated apoptosis
has exact synonym: regulation of T-cell mediated apoptosis
has exact synonym: regulation of T cell mediated cell death
has exact synonym: regulation of T-cell mediated cell death
has exact synonym: regulation of T cell mediated cell killing
has exact synonym: regulation of T-cell mediated cell killing
has related synonym: regulation of T cell mediated cytolysis
has related synonym: regulation of T-cell mediated cytolysis
has exact synonym: regulation of T-cell mediated cytotoxicity
has exact synonym: regulation of T lymphocyte mediated cytotoxicity
has exact synonym: regulation of T-lymphocyte mediated cytotoxicity

negative regulation of T cell mediated cytotoxicity
type: Class
subclass of: negative regulation of leukocyte mediated cytotoxicity
subclass of: regulation of T cell mediated cytotoxicity
subclass of: negative regulation of T cell mediated immunity
IAO_0000115: Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity.
has exact synonym: downregulation of T cell mediated cytotoxicity
has exact synonym: down regulation of T cell mediated cytotoxicity
has exact synonym: down-regulation of T cell mediated cytotoxicity
has related synonym: inhibition of T cell mediated cytotoxicity
has exact synonym: negative regulation of T cell mediated apoptosis
has exact synonym: negative regulation of T-cell mediated apoptosis
has exact synonym: negative regulation of T cell mediated cell death
has exact synonym: negative regulation of T-cell mediated cell death
has exact synonym: negative regulation of T cell mediated cell killing
has exact synonym: negative regulation of T-cell mediated cell killing
has related synonym: negative regulation of T cell mediated cytolysis
has related synonym: negative regulation of T-cell mediated cytolysis
has exact synonym: negative regulation of T-cell mediated cytotoxicity
has exact synonym: negative regulation of T lymphocyte mediated cytotoxicity
has exact synonym: negative regulation of T-lymphocyte mediated cytotoxicity

positive regulation of T cell mediated cytotoxicity
type: Class
subclass of: positive regulation of leukocyte mediated cytotoxicity
subclass of: regulation of T cell mediated cytotoxicity
subclass of: positive regulation of T cell mediated immunity
IAO_0000115: Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.
has related synonym: activation of T cell mediated cytotoxicity
has exact synonym: positive regulation of T cell mediated apoptosis
has exact synonym: positive regulation of T-cell mediated apoptosis
has exact synonym: positive regulation of T cell mediated cell death
has exact synonym: positive regulation of T-cell mediated cell death
has exact synonym: positive regulation of T cell mediated cell killing
has exact synonym: positive regulation of T-cell mediated cell killing
has related synonym: positive regulation of T cell mediated cytolysis
has related synonym: positive regulation of T-cell mediated cytolysis
has exact synonym: positive regulation of T-cell mediated cytotoxicity
has exact synonym: positive regulation of T lymphocyte mediated cytotoxicity
has exact synonym: positive regulation of T-lymphocyte mediated cytotoxicity
has related synonym: stimulation of T cell mediated cytotoxicity
has exact synonym: upregulation of T cell mediated cytotoxicity
has exact synonym: up regulation of T cell mediated cytotoxicity
has exact synonym: up-regulation of T cell mediated cytotoxicity

photoreceptor inner segment
type: Class
subclass of: GO_0110165
IAO_0000115: The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.

farnesylated protein binding
type: Class
subclass of: GO_0005515
IAO_0000115: Binding to a farnesylated protein.

regulation of receptor recycling
type: Class
subclass of: GO_0023051
subclass of: GO_0031323
subclass of: GO_0060255
IAO_0000115: Any process that modulates the frequency, rate, or extent of receptor recycling.

negative regulation of receptor recycling
type: Class
subclass of: regulation of receptor recycling
subclass of: GO_0010605
subclass of: GO_0023057
subclass of: GO_0031324
IAO_0000115: Any process that stops, prevents, or reduces the rate of receptor recycling.
has exact synonym: downregulation of receptor recycling
has exact synonym: down regulation of receptor recycling
has exact synonym: down-regulation of receptor recycling
has related synonym: inhibition of receptor recycling

positive regulation of receptor recycling
type: Class
subclass of: regulation of receptor recycling
subclass of: GO_0010604
subclass of: GO_0023056
subclass of: GO_0031325
IAO_0000115: Any process that activates or increases the frequency, rate or extent of receptor recycling.
has related synonym: activation of receptor recycling
has related synonym: stimulation of receptor recycling
has exact synonym: upregulation of receptor recycling
has exact synonym: up regulation of receptor recycling
has exact synonym: up-regulation of receptor recycling

B-1 B cell homeostasis
type: Class
subclass of: B cell homeostasis
IAO_0000115: The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.
has exact synonym: B-1 B-cell homeostasis
has exact synonym: B-1 B lymphocyte homeostasis
has exact synonym: B-1 B-lymphocyte homeostasis

B-1 B cell differentiation
type: Class
subclass of: mature B cell differentiation
IAO_0000115: The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.
has related synonym: B-1 B cell development
has exact synonym: B-1 B-cell differentiation
has exact synonym: B-1 B lymphocyte differentiation
has exact synonym: B-1 B-lymphocyte differentiation

regulation of B-1 B cell differentiation
type: Class
subclass of: GO_0045577
IAO_0000115: Any process that modulates the frequency, rate, or extent of B-1 B cell differentiation. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.
has related synonym: regulation of B-1 B cell development
has exact synonym: regulation of B-1 B-cell differentiation
has exact synonym: regulation of B-1 B lymphocyte differentiation
has exact synonym: regulation of B-1 B-lymphocyte differentiation

negative regulation of B-1 B cell differentiation
type: Class
subclass of: regulation of B-1 B cell differentiation
subclass of: GO_0045578
IAO_0000115: Any process that stops, prevents, or reduces the rate of B-1 B cell differentiation.
has exact synonym: downregulation of B-1 B cell differentiation
has exact synonym: down regulation of B-1 B cell differentiation
has exact synonym: down-regulation of B-1 B cell differentiation
has related synonym: inhibition of B-1 B cell differentiation
has related synonym: negative regulation of B-1 B cell development
has exact synonym: negative regulation of B-1 B-cell differentiation
has exact synonym: negative regulation of B-1 B lymphocyte differentiation
has exact synonym: negative regulation of B-1 B-lymphocyte differentiation

positive regulation of B-1 B cell differentiation
type: Class
subclass of: regulation of B-1 B cell differentiation
subclass of: GO_0045579
IAO_0000115: Any process that activates or increases the frequency, rate or extent of B-1 B cell differentiation.
has related synonym: activation of B-1 B cell differentiation
has related synonym: positive regulation of B-1 B cell development
has exact synonym: positive regulation of B-1 B-cell differentiation
has exact synonym: positive regulation of B-1 B lymphocyte differentiation
has exact synonym: positive regulation of B-1 B-lymphocyte differentiation
has related synonym: stimulation of B-1 B cell differentiation
has exact synonym: upregulation of B-1 B cell differentiation
has exact synonym: up regulation of B-1 B cell differentiation
has exact synonym: up-regulation of B-1 B cell differentiation

exocyst assembly
type: Class
subclass of: GO_0065003
subclass of: GO_0140029
subclass of: part-of-parent-6904
IAO_0000115: The aggregation, arrangement and bonding together of various polypeptides into the exocyst complex.

regulation of exocyst assembly
type: Class
subclass of: GO_0043254
subclass of: GO_0106020
IAO_0000115: Any process that modulates the frequency, rate or extent of exocyst assembly.

negative regulation of exocyst assembly
type: Class
subclass of: regulation of exocyst assembly
subclass of: GO_0031333
subclass of: GO_0045920
IAO_0000115: Any process that stops, prevents, or reduces the rate or extent of exocyst assembly.
has exact synonym: downregulation of exocyst assembly
has exact synonym: down regulation of exocyst assembly
has exact synonym: down-regulation of exocyst assembly
has related synonym: inhibition of exocyst assembly

positive regulation of exocyst assembly
type: Class
subclass of: regulation of exocyst assembly
subclass of: GO_0031334
IAO_0000115: Any process that increases the rate or extent of exocyst assembly.
has related synonym: activation of exocyst assembly
has related synonym: stimulation of exocyst assembly
has exact synonym: upregulation of exocyst assembly
has exact synonym: up regulation of exocyst assembly
has exact synonym: up-regulation of exocyst assembly

uropod
type: Class
subclass of: GO_0120025
subclass of: part-of-parent-31254
IAO_0000115: A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively.
has related synonym: distal pole complex
has related synonym: retractile pole
has exact synonym: uropodium

regulation of protein phosphorylation
type: Class
subclass of: GO_0031399
subclass of: GO_0042325
IAO_0000115: Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
has exact synonym: regulation of protein amino acid phosphorylation

negative regulation of protein phosphorylation
type: Class
subclass of: regulation of protein phosphorylation
subclass of: GO_0031400
subclass of: GO_0042326
IAO_0000115: Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
has exact synonym: downregulation of protein amino acid phosphorylation
has exact synonym: down regulation of protein amino acid phosphorylation
has exact synonym: down-regulation of protein amino acid phosphorylation
has related synonym: inhibition of protein amino acid phosphorylation
has exact synonym: negative regulation of protein amino acid phosphorylation

positive regulation of protein phosphorylation
type: Class
subclass of: regulation of protein phosphorylation
subclass of: GO_0031401
subclass of: GO_0042327
IAO_0000115: Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
has related synonym: activation of protein amino acid phosphorylation
has exact synonym: positive regulation of protein amino acid phosphorylation
has related synonym: stimulation of protein amino acid phosphorylation
has exact synonym: upregulation of protein amino acid phosphorylation
has exact synonym: up regulation of protein amino acid phosphorylation
has exact synonym: up-regulation of protein amino acid phosphorylation

endothelial cell proliferation
type: Class
subclass of: GO_0050673
IAO_0000115: The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.

regulation of endothelial cell proliferation
type: Class
subclass of: GO_0050678
IAO_0000115: Any process that modulates the frequency, rate, or extent of endothelial cell proliferation.

negative regulation of endothelial cell proliferation
type: Class
subclass of: regulation of endothelial cell proliferation
subclass of: GO_0050680
IAO_0000115: Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.
has exact synonym: downregulation of endothelial cell proliferation
has exact synonym: down regulation of endothelial cell proliferation
has exact synonym: down-regulation of endothelial cell proliferation
has related synonym: inhibition of endothelial cell proliferation

positive regulation of endothelial cell proliferation
type: Class
subclass of: regulation of endothelial cell proliferation
subclass of: GO_0050679
IAO_0000115: Any process that activates or increases the rate or extent of endothelial cell proliferation.
has related synonym: activation of endothelial cell proliferation
has related synonym: stimulation of endothelial cell proliferation
has exact synonym: upregulation of endothelial cell proliferation
has exact synonym: up regulation of endothelial cell proliferation
has exact synonym: up-regulation of endothelial cell proliferation

female pronucleus
type: Class
subclass of: GO_0045120
IAO_0000115: The pronucleus originating from the ovum that is being fertilized.

male pronucleus
type: Class
subclass of: GO_0045120
IAO_0000115: The pronucleus originating from the spermatozoa that was involved in fertilization.

postsynaptic membrane organization
type: Class
subclass of: GO_0061024
subclass of: part-of-parent-99173
IAO_0000115: A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).
has exact synonym: postsynaptic membrane organisation
has exact synonym: post-synaptic membrane organization

hair follicle development
type: Class
subclass of: GO_0022405
subclass of: GO_0048856
subclass of: part-of-parent-98773
IAO_0000115: The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open.
replaces: GO_0001943

vasculature development
type: Class
subclass of: GO_0048731
subclass of: part-of-parent-72359
IAO_0000115: The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.
has related synonym: vascular system development

lymph vessel development
type: Class
subclass of: GO_0048856
subclass of: part-of-parent-1944
IAO_0000115: The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure.

lymphangiogenesis
type: Class
subclass of: GO_0009653
subclass of: GO_0048646
subclass of: part-of-parent-36303
IAO_0000115: Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels.
has exact synonym: lymph vessel formation

heart looping
type: Class
subclass of: embryonic heart tube morphogenesis
subclass of: part-of-parent-61371
IAO_0000115: The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.
has exact synonym: cardiac looping

sebaceous gland cell differentiation
type: Class
subclass of: GO_0009913
subclass of: part-of-parent-48733
IAO_0000115: The process in which a relatively unspecialized epidermal cell acquires the specialized features of a sebaceous gland cell.
has related synonym: sebocytes differentiation

obsolete plasma membrane enriched fraction
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The fraction of cells, prepared by disruptive biochemical methods, that is enriched for plasma membranes.

intestinal D-glucose absorption
type: Class
subclass of: GO_0106001
IAO_0000115: Uptake of D-glucose into the blood by absorption from the small intestine.

regulation of cell-matrix adhesion
type: Class
subclass of: GO_0010810
IAO_0000115: Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix.

negative regulation of cell-matrix adhesion
type: Class
subclass of: regulation of cell-matrix adhesion
subclass of: GO_0010812
IAO_0000115: Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix.
has exact synonym: downregulation of cell-matrix adhesion
has exact synonym: down regulation of cell-matrix adhesion
has exact synonym: down-regulation of cell-matrix adhesion
has related synonym: inhibition of cell-matrix adhesion

positive regulation of cell-matrix adhesion
type: Class
subclass of: regulation of cell-matrix adhesion
subclass of: GO_0010811
IAO_0000115: Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.
has related synonym: activation of cell-matrix adhesion
has related synonym: stimulation of cell-matrix adhesion
has exact synonym: upregulation of cell-matrix adhesion
has exact synonym: up regulation of cell-matrix adhesion
has exact synonym: up-regulation of cell-matrix adhesion

blood vessel maturation
type: Class
subclass of: GO_0071695
subclass of: part-of-parent-1568
IAO_0000115: A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state.

positive regulation of neurotransmitter secretion
type: Class
subclass of: GO_0046928
subclass of: GO_0050806
subclass of: GO_0051590
subclass of: GO_1903532
IAO_0000115: Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter.
has related synonym: activation of neurotransmitter secretion
has related synonym: stimulation of neurotransmitter secretion
has exact synonym: upregulation of neurotransmitter secretion
has exact synonym: up regulation of neurotransmitter secretion
has exact synonym: up-regulation of neurotransmitter secretion

intramembranous ossification
type: Class
subclass of: GO_0036072
IAO_0000115: Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells.
has related synonym: dermal ossification
has related synonym: intramembranous bone ossification

endochondral ossification
type: Class
subclass of: GO_0036075
subclass of: part-of-parent-60350
IAO_0000115: Replacement ossification wherein bone tissue replaces cartilage.

regulation of cytokine-mediated signaling pathway
type: Class
subclass of: GO_0009966
subclass of: GO_0060759
IAO_0000115: Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway.
has exact synonym: regulation of cytokine and chemokine mediated signaling pathway
has exact synonym: regulation of cytokine mediated signaling pathway
has exact synonym: regulation of cytokine mediated signalling pathway

negative regulation of cytokine-mediated signaling pathway
type: Class
subclass of: regulation of cytokine-mediated signaling pathway
subclass of: GO_0009968
subclass of: GO_0060761
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway.
has exact synonym: downregulation of cytokine mediated signaling pathway
has exact synonym: down regulation of cytokine mediated signaling pathway
has exact synonym: down-regulation of cytokine mediated signaling pathway
has related synonym: inhibition of cytokine mediated signaling pathway
has exact synonym: negative regulation of cytokine and chemokine mediated signaling pathway
has exact synonym: negative regulation of cytokine mediated signaling pathway
has exact synonym: negative regulation of cytokine mediated signalling pathway

positive regulation of cytokine-mediated signaling pathway
type: Class
subclass of: regulation of cytokine-mediated signaling pathway
subclass of: GO_0009967
subclass of: GO_0060760
IAO_0000115: Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway.
has related synonym: activation of cytokine mediated signaling pathway
has exact synonym: positive regulation of cytokine and chemokine mediated signaling pathway
has exact synonym: positive regulation of cytokine mediated signaling pathway
has exact synonym: positive regulation of cytokine mediated signalling pathway
has related synonym: stimulation of cytokine mediated signaling pathway
has exact synonym: upregulation of cytokine mediated signaling pathway
has exact synonym: up regulation of cytokine mediated signaling pathway
has exact synonym: up-regulation of cytokine mediated signaling pathway

alpha-1,3-galactosyltransferase activity
type: Class
subclass of: GO_0008378
IAO_0000115: Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-(1->3) linkage.
has related synonym: isoglobotriaosylceramide synthase

synaptic transmission, dopaminergic
type: Class
subclass of: GO_0007268
IAO_0000115: The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
has exact synonym: dopaminergic synaptic transmission

startle response
type: Class
subclass of: GO_0009605
subclass of: GO_0050905
IAO_0000115: An action or movement due to the application of a sudden unexpected stimulus.

G-protein alpha-subunit binding
type: Class
subclass of: GO_0005515
IAO_0000115: Binding to a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide.
has exact synonym: G-alpha protein subunit binding

thigmotaxis
type: Class
subclass of: GO_0007610
IAO_0000115: The directed movement of an animal in response to touch.
has exact synonym: stereotaxis
has related synonym: taxis in response to mechanical stimulus
has exact synonym: taxis in response to touch stimulus

suckling behavior
type: Class
subclass of: GO_0007631
IAO_0000115: Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast.
has exact synonym: nursing behavior

fibronectin binding
type: Class
subclass of: GO_0005515
IAO_0000115: Binding to a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.

regulation of activation of membrane attack complex
type: Class
subclass of: GO_0030449
IAO_0000115: Any process that modulates the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade.
has exact synonym: regulation of activation of MAC
has related synonym: regulation of activation of TCC
has related synonym: regulation of activation of terminal complement complex
has related synonym: regulation of activation of the terminal complement cascade
has exact synonym: regulation of MAC assembly
has exact synonym: regulation of MAC formation
has exact synonym: regulation of membrane attack complex assembly
has exact synonym: regulation of membrane attack complex formation

positive regulation of activation of membrane attack complex
type: Class
subclass of: regulation of activation of membrane attack complex
subclass of: GO_0045917
IAO_0000115: Any process that activates, maintains or increases the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade.
has related synonym: activation of activation of membrane attack complex
has exact synonym: positive regulation of activation of MAC
has related synonym: positive regulation of activation of TCC
has related synonym: positive regulation of activation of terminal complement complex
has related synonym: positive regulation of activation of the terminal complement cascade
has exact synonym: positive regulation of MAC assembly
has exact synonym: positive regulation of MAC formation
has exact synonym: positive regulation of membrane attack complex assembly
has exact synonym: positive regulation of membrane attack complex formation
has related synonym: stimulation of activation of membrane attack complex
has exact synonym: upregulation of activation of membrane attack complex
has exact synonym: up regulation of activation of membrane attack complex
has exact synonym: up-regulation of activation of membrane attack complex

negative regulation of activation of membrane attack complex
type: Class
subclass of: regulation of activation of membrane attack complex
subclass of: GO_0045916
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade.
has exact synonym: downregulation of activation of membrane attack complex
has exact synonym: down regulation of activation of membrane attack complex
has exact synonym: down-regulation of activation of membrane attack complex
has related synonym: inhibition of activation of membrane attack complex
has exact synonym: negative regulation of activation of MAC
has related synonym: negative regulation of activation of TCC
has related synonym: negative regulation of activation of terminal complement complex
has related synonym: negative regulation of activation of the terminal complement cascade
has exact synonym: negative regulation of MAC assembly
has exact synonym: negative regulation of MAC formation
has exact synonym: negative regulation of membrane attack complex assembly
has exact synonym: negative regulation of membrane attack complex formation

retinoic acid binding
type: Class
subclass of: GO_0005501
subclass of: GO_0033293
subclass of: GO_0043177
IAO_0000115: Binding to retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid.

G protein-coupled adenosine receptor signaling pathway
type: Class
subclass of: GO_0035588
IAO_0000115: The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity.
has related synonym: adenosine receptor signaling pathway
has exact synonym: adenosine receptor signaling pathway, G-protein coupled
has exact synonym: adenosine receptor signalling pathway
has exact synonym: P1 receptor signaling pathway

blood vessel remodeling
type: Class
subclass of: GO_0048771
IAO_0000115: The reorganization or renovation of existing blood vessels.

response to amphetamine
type: Class
subclass of: GO_0014075
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine.

nervous system process involved in regulation of systemic arterial blood pressure
type: Class
subclass of: GO_0050877
subclass of: part-of-parent-3073
IAO_0000115: The regulation of blood pressure mediated by detection of stimuli and a neurological response.
has exact synonym: blood pressure regulation by neurological process
has related synonym: fast control of arterial pressure
has exact synonym: neurological process involved in regulation of systemic arterial blood pressure
has exact synonym: neurological system process involved in regulation of systemic arterial blood pressure

renal system process involved in regulation of blood volume
type: Class
subclass of: renal system process involved in regulation of systemic arterial blood pressure
subclass of: part-of-parent-50878
IAO_0000115: A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system.
has related synonym: renal blood volume control of blood pressure
has related synonym: renal regulation of blood volume

regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback
type: Class
subclass of: nervous system process involved in regulation of systemic arterial blood pressure
subclass of: part-of-parent-3025
IAO_0000115: The process that modulates blood pressure by sensing the amount of stretch occurring in large arteries and responding to the input via central nervous system control.
has related synonym: baroreceptor feedback control of blood pressure
has related synonym: baroreceptor pressure buffer system
has exact synonym: carotid sinus baroreceptor feedback regulation of systemic arterial blood pressure

regulation of systemic arterial blood pressure by chemoreceptor signaling
type: Class
subclass of: nervous system process involved in regulation of systemic arterial blood pressure
IAO_0000115: The process that modulates blood pressure by the action of chemoreceptors found in the carotid and aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions.
has related synonym: chemoreceptor control of blood pressure
has exact synonym: chemoreceptor regulation of systemic arterial blood pressure
has exact synonym: regulation of systemic arterial blood pressure by chemoreceptor signalling

regulation of systemic arterial blood pressure by ischemic conditions
type: Class
subclass of: nervous system process involved in regulation of systemic arterial blood pressure
IAO_0000115: The process that modulates blood pressure by the detection of carbon dioxide levels in the brain stem. Increased levels activate the sympathetic vasoconstrictor mechanism increasing the force with which blood flows through the circulatory system.
has related synonym: CNS ischemic response
has related synonym: ischemic control of blood pressure
has exact synonym: ischemic regulation of systemic arterial blood pressure

baroreceptor detection of arterial stretch
type: Class
subclass of: vascular process in circulatory system
subclass of: GO_0050982
subclass of: part-of-parent-1978
IAO_0000115: The series of events by which the change in diameter of an artery is detected and converted to a molecular signal.

baroreceptor response to decreased systemic arterial blood pressure
type: Class
subclass of: regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback
subclass of: positive regulation of systemic arterial blood pressure
IAO_0000115: The lowering of the number of nerve impulses from baroreceptors as a result of decreased stretch of an artery that results in an increased in sympathetic nerve impulses to peripheral blood vessels.

baroreceptor response to increased systemic arterial blood pressure
type: Class
subclass of: regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback
subclass of: negative regulation of systemic arterial blood pressure
IAO_0000115: The increase in nerve impulses from baroreceptors as a result of increased pressure on an artery that results in an inhibition of sympathetic nerve impulses to peripheral blood vessels.

artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure
type: Class
subclass of: GO_0042311
subclass of: part-of-parent-1983
IAO_0000115: An increase in the internal diameter of an artery, triggered by vasomotor suppression, during the chemoreceptor response to decreased blood pressure.
has exact synonym: vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure

negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
type: Class
subclass of: GO_0010459
subclass of: part-of-parent-1983
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction as a result of the baroreceptor response to increased blood pressure.
has exact synonym: downregulation of heart contraction rate in baroreceptor response to increased blood pressure
has exact synonym: down regulation of heart contraction rate in baroreceptor response to increased blood pressure
has exact synonym: down-regulation of heart contraction rate in baroreceptor response to increased blood pressure
has related synonym: inhibition of heart contraction rate in baroreceptor response to increased blood pressure
has exact synonym: negative control of heart contraction rate in baroreceptor response to increased blood pressure
has related synonym: negative regulation of cardiac contraction rate in baroreceptor response to increased blood pressure
has exact synonym: negative regulation of heart contraction rate in baroreceptor response to increased blood pressure

negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure
type: Class
subclass of: GO_0045822
subclass of: part-of-parent-1983
IAO_0000115: Any process that decreases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the baroreceptor response to increased blood pressure.
has exact synonym: decreased force of heart contraction during baroreceptor response to increased systemic arterial blood pressure
has exact synonym: decreased strength of cardiac contraction during baroreceptor response to increased blood pressure

vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure
type: Class
subclass of: GO_0042310
subclass of: part-of-parent-1982
IAO_0000115: A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the baroreceptor response to decreased blood pressure.

positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure
type: Class
subclass of: GO_0010460
subclass of: part-of-parent-1982
IAO_0000115: Any process that activates, maintains or increases the frequency, rate or extent of heart contraction as a result of the baroreceptor response to decreased blood pressure.
has related synonym: activation of heart contraction rate in baroreceptor response to decreased blood pressure
has exact synonym: positive control of heart contraction rate in baroreceptor response to decreased blood pressure
has exact synonym: positive regulation of cardiac contraction rate in baroreceptor response to decreased blood pressure
has related synonym: positive regulation of heart contraction rate in baroreceptor response to decreased blood pressure
has related synonym: stimulation of heart contraction rate in baroreceptor response to decreased blood pressure
has exact synonym: upregulation of heart contraction rate in baroreceptor response to decreased blood pressure
has exact synonym: up regulation of heart contraction rate in baroreceptor response to decreased blood pressure
has exact synonym: up-regulation of heart contraction rate in baroreceptor response to decreased blood pressure

positive regulation of the force of heart contraction involved in baroreceptor response to decreased systemic arterial blood pressure
type: Class
subclass of: GO_0045823
subclass of: part-of-parent-1982
IAO_0000115: Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as part of the baroreceptor response to decreased blood pressure.
has related synonym: increased force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure
has related synonym: increased strength of cardiac contraction during baroreceptor response to decreased blood pressure
has related synonym: positive regulation of the force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure

regulation of systemic arterial blood pressure by hormone
type: Class
subclass of: regulation of systemic arterial blood pressure mediated by a chemical signal
subclass of: GO_0050886
IAO_0000115: The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.
has exact synonym: blood pressure regulation by hormone
has related synonym: hormonal control of blood pressure
has exact synonym: hormonal regulation of blood pressure

regulation of systemic arterial blood pressure by circulatory renin-angiotensin
type: Class
subclass of: regulation of systemic arterial blood pressure by renin-angiotensin
IAO_0000115: The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen.
has exact synonym: circulatory renin-angiotensin blood pressure regulation
has related synonym: circulatory renin-angiotensin control of blood pressure
has exact synonym: circulatory renin-angiotensin regulation of blood pressure
has related synonym: control of blood pressure by circulatory renin-angiotensin
has related synonym: renin-angiotensin blood pressure control

regulation of systemic arterial blood pressure by vasopressin
type: Class
subclass of: regulation of systemic arterial blood pressure by hormone
IAO_0000115: The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport.
has exact synonym: blood pressure regulation by vasopressin
has related synonym: vasopressin control of blood pressure

regulation of systemic arterial blood pressure by norepinephrine-epinephrine
type: Class
subclass of: regulation of systemic arterial blood pressure mediated by a chemical signal
IAO_0000115: The process in which the secretion of norepinephrine or epinephrine into the bloodstream modulates the force with which blood passes through the circulatory system.
has related synonym: noradrenaline-adrenaline regulation of blood pressure
has related synonym: norepinephrine-epinephrine blood pressure control
has exact synonym: norepinephrine-epinephrine blood pressure regulation

norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
type: Class
subclass of: GO_0042310
subclass of: part-of-parent-3321
IAO_0000115: A process that results in a decrease in the diameter of an artery during the norepinephrine-epinephrine response to decreased blood pressure.
has exact synonym: noradrenaline-adrenaline vasoconstriction involved in regulation of blood pressure
has related synonym: norepinephrine-epinephrine vasoconstriction during blood pressure control
has exact synonym: norepinephrine-epinephrine vasoconstriction during blood pressure regulation
has related synonym: norepinephrine-epinephrine vasoconstriction during control of blood pressure

norepinephrine-epinephrine catabolic process in blood stream
type: Class
subclass of: GO_0042419
subclass of: part-of-parent-1993
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of norepinephrine or epinephrine in the bloodstream.
has exact synonym: noradrenaline-adrenalin catabolic process in blood stream

positive regulation of heart rate by epinephrine-norepinephrine
type: Class
subclass of: GO_0010460
subclass of: part-of-parent-3321
IAO_0000115: The process in which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction.
has related synonym: activation of heart contraction rate by epinephrine-norepinephrine
has related synonym: increased chronotropy by epinephrine-norepinephrine
has related synonym: positive control of heart contraction rate by epinephrine-norepinephrine
has exact synonym: positive regulation of cardiac contraction rate by epinephrine-norepinephrine
has exact synonym: positive regulation of heart contraction rate by adrenaline-noradrenaline
has related synonym: positive regulation of heart contraction rate by epinephrine-norepinephrine
has related synonym: stimulation of heart contraction rate by epinephrine-norepinephrine
has exact synonym: upregulation of heart contraction rate by epinephrine-norepinephrine
has exact synonym: up regulation of heart contraction rate by epinephrine-norepinephrine
has exact synonym: up-regulation of heart contraction rate by epinephrine-norepinephrine

positive regulation of the force of heart contraction by epinephrine-norepinephrine
type: Class
subclass of: positive regulation of the force of heart contraction by chemical signal
subclass of: part-of-parent-3321
IAO_0000115: Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream or released from the nerve endings.
has exact synonym: increased force of heart contraction by adrenaline-noradrenaline
has exact synonym: increased force of heart contraction by epinephrine-norepinephrine
has related synonym: increased inotropy by epinephrine-norepinephrine
has exact synonym: increased strength of cardiac contraction by epinephrine-norepinephrine
has related synonym: positive regulation of heart contraction by adrenaline-noradrenaline
has related synonym: positive regulation of heart contraction by epinephrine-norepinephrine

angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
type: Class
subclass of: positive regulation of systemic arterial blood pressure
subclass of: GO_0042310
subclass of: part-of-parent-2034
IAO_0000115: The decrease in blood vessel diameter as a result of the release of angiotensin into the blood stream.
has related synonym: angiotensin mediated vasoconstriction during blood pressure control
has exact synonym: angiotensin mediated vasoconstriction during blood pressure regulation
has related synonym: angiotensin mediated vasoconstriction during control of blood pressure
has exact synonym: angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure

renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure
type: Class
subclass of: renal system process involved in regulation of systemic arterial blood pressure
subclass of: part-of-parent-1991
IAO_0000115: The physiological response of the kidneys to a decrease in blood flow.
has related synonym: renal response to blood flow during renin-angiotensin control of blood pressure

detection of renal blood flow
type: Class
subclass of: GO_0050982
subclass of: part-of-parent-1999
IAO_0000115: The process in which the juxtaglomerular cells of the kidneys receive information about the amount of blood flowing through the arterioles and converts the information to a molecular signal.

renin secretion into blood stream
type: Class
subclass of: GO_0009306
subclass of: GO_0023061
subclass of: part-of-parent-1999
IAO_0000115: The regulated release of renin into the blood stream by juxtoglomerular cells.
has exact synonym: renin release into blood stream

regulation of angiotensin levels in blood
type: Class
subclass of: GO_0010817
subclass of: part-of-parent-1991
IAO_0000115: The process that modulates the level of any of the various angiotensinogen proteolytic products in the blood. This occurs by the proteolytic cleavage of angiotensinogen, and its proteolytic products, to create a variety of active peptide hormones, such as angiotensin I and angiotensin II, as well as through the removal of these peptides from the circulation.
has related synonym: control of angiotensin levels in blood
has related synonym: control of blood angiotensin level
has exact synonym: regulation of blood angiotensin level

angiotensin maturation
type: Class
subclass of: GO_0016486
subclass of: part-of-parent-2002
IAO_0000115: The process leading to the attainment of the full functional capacity of angiotensin by conversion of angiotensinogen into mature angiotensin in the blood.
has related synonym: angiotensin catabolic process in blood
replaces: GO_0002005

secretion of vasopressin involved in fast regulation of systemic arterial blood pressure
type: Class
subclass of: GO_0030103
subclass of: part-of-parent-1992
IAO_0000115: The regulated release of the hormone vasopressin into the blood stream by the hypothalamus and pituitary gland contributing to fast regulation of blood pressure.
has related synonym: secretion of vasopressin during fast control of blood pressure
has related synonym: secretion of vasopressin during fast regulation of systemic arterial blood pressure

vasoconstriction by vasopressin involved in systemic arterial blood pressure control
type: Class
subclass of: positive regulation of systemic arterial blood pressure
subclass of: GO_0042310
subclass of: part-of-parent-1992
IAO_0000115: The decrease in blood vessel diameter as a result of the release of vasopressin into the blood stream.
has exact synonym: vasopressin mediated vasoconstriction involved in systemic arterial blood pressure control

detection of hypoxic conditions in blood by chemoreceptor signaling
type: Class
subclass of: GO_0009593
subclass of: part-of-parent-1979
subclass of: part-of-parent-70887
IAO_0000115: The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies.
has exact synonym: detection of hypoxic conditions in blood by chemoreceptor signalling

excitation of vasomotor center by chemoreceptor signaling
type: Class
subclass of: nervous system process involved in regulation of systemic arterial blood pressure
subclass of: part-of-parent-1979
subclass of: part-of-parent-3084
IAO_0000115: The process in which the molecular signal from the carotid and aortic bodies is relayed to the vasomotor center, causing it to signal an increase arterial pressure.
has exact synonym: excitation of vasomotor center by chemoreceptor signalling

morphogenesis of an epithelium
type: Class
subclass of: GO_0048729
subclass of: part-of-parent-60429
IAO_0000115: The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.
has exact synonym: epithelium morphogenesis

excitation of vasomotor center by baroreceptor signaling
type: Class
subclass of: nervous system process involved in regulation of systemic arterial blood pressure
subclass of: part-of-parent-1982
IAO_0000115: The process in which the molecular signal from the arterial baroreceptors is relayed to the vasomotor center causing it to signal increase arterial pressure.
has exact synonym: excitation of vasomotor center by baroreceptor signalling

morphogenesis of an epithelial sheet
type: Class
subclass of: morphogenesis of an epithelium
IAO_0000115: The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells.

vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure
type: Class
subclass of: positive regulation of systemic arterial blood pressure
subclass of: GO_0042310
subclass of: part-of-parent-1979
IAO_0000115: A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure.

detection of carbon dioxide by vasomotor center
type: Class
subclass of: detection of carbon dioxide
subclass of: part-of-parent-1980
IAO_0000115: The process by a carbon dioxide stimulus is received and converted to a molecular signal by the vasomotor center of the central nervous system.

vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure
type: Class
subclass of: positive regulation of systemic arterial blood pressure
subclass of: GO_0042310
subclass of: part-of-parent-1980
IAO_0000115: The vasoconstriction that is triggered by vasomotor excitation resulting from the detection of high carbon dioxide levels in the vasomotor center of the central nervous system.

regulation of systemic arterial blood pressure by atrial baroreceptor feedback
type: Class
subclass of: heart process
subclass of: part-of-parent-3025
IAO_0000115: A process that controls blood pressure by sensing the amount of stretch occurring in the atria.
has exact synonym: atrial baroreceptor regulation of systemic arterial blood pressure
has related synonym: atrial control of blood pressure
has exact synonym: atrial low pressure baroreceptor regulation of blood pressure
has related synonym: atrial reflex

regulation of blood volume by renin-angiotensin
type: Class
subclass of: regulation of systemic arterial blood pressure by renin-angiotensin
IAO_0000115: The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood.
has related synonym: renin-angiotensin control of body fluid levels
has exact synonym: renin-angiotensin regulation of blood volume

regulation of blood volume by renal aldosterone
type: Class
subclass of: renal system process involved in regulation of blood volume
subclass of: regulation of systemic arterial blood pressure by hormone
subclass of: positive regulation of systemic arterial blood pressure
IAO_0000115: The process in which the hormone aldosterone decreases the rate of diuresis and natriuresis resulting in increased blood volume.
has related synonym: aldosterone mediated control of body fluids
has exact synonym: aldosterone mediated regulation of blood volume
has exact synonym: renal regulation of blood volume by aldosterone

renin-angiotensin regulation of aldosterone production
type: Class
subclass of: renal system process involved in regulation of systemic arterial blood pressure
subclass of: GO_2000858
subclass of: part-of-parent-2016
IAO_0000115: The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone.
has related synonym: renin-angiotensin control of aldosterone production

regulation of renal output by angiotensin
type: Class
subclass of: regulation of blood volume by renin-angiotensin
IAO_0000115: The process in which angiotensin directly modulates the rate of urine output by the kidney.
has related synonym: angiotensin mediated control of renal output
has exact synonym: angiotensin mediated regulation of renal output
has exact synonym: angiotensin-mediated regulation of renal output

protease binding
type: Class
subclass of: GO_0019899
IAO_0000115: Binding to a protease or a peptidase.

response to dietary excess
type: Class
subclass of: GO_0031667
subclass of: GO_0032501
IAO_0000115: The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure.

detection of dietary excess
type: Class
subclass of: GO_0050877
subclass of: part-of-parent-2021
IAO_0000115: The neurological process in which the brain senses excessive caloric intake.

reduction of food intake in response to dietary excess
type: Class
subclass of: GO_0042755
subclass of: part-of-parent-2021
IAO_0000115: An eating behavior process whereby detection of a dietary excess results in a decrease in intake of nutrients.

diet induced thermogenesis
type: Class
subclass of: GO_1990845
subclass of: part-of-parent-2021
IAO_0000115: The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system.

norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure
type: Class
subclass of: negative regulation of systemic arterial blood pressure
subclass of: GO_0042311
subclass of: part-of-parent-1993
IAO_0000115: A process that results in an increase in the diameter of an artery during the norepinephrine-epinephrine response to blood pressure change.
has exact synonym: noradrenaline-adrenaline vasodilation involved in regulation of blood pressure
has exact synonym: norepinephrine-epinephrine vasodilation during blood pressure regulation
has exact synonym: vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure

regulation of the force of heart contraction
type: Class
subclass of: GO_0008016
subclass of: GO_0065008
IAO_0000115: Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.
has exact synonym: cardiac inotropy
has exact synonym: heart inotropy

regulation of heart rate
type: Class
subclass of: GO_0008016
subclass of: GO_0065008
IAO_0000115: Any process that modulates the frequency or rate of heart contraction.
has exact synonym: cardiac chronotropy
has exact synonym: regulation of heart contraction rate
has exact synonym: regulation of rate of heart contraction

regulation of sodium ion transport
type: Class
subclass of: GO_0010959
IAO_0000115: Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has exact synonym: regulation of Na+ transport
has exact synonym: regulation of sodium transport

desensitization of G protein-coupled receptor signaling pathway
type: Class
subclass of: GO_0022401
subclass of: GO_0045744
IAO_0000115: The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway.
has exact synonym: desensitisation of G-protein coupled receptor protein signalling pathway
has exact synonym: desensitization of G-protein coupled receptor protein signaling pathway

inhibitory G protein-coupled receptor phosphorylation
type: Class
subclass of: GO_0006468
subclass of: part-of-parent-2029
IAO_0000115: The process that inhibits the signaling function of a G protein-coupled receptor by addition of a phosphate group to its third intracellular loop consensus site.
has exact synonym: inhibitory G-protein coupled receptor phosphorylation

G protein-coupled receptor internalization
type: Class
subclass of: GO_0031623
subclass of: part-of-parent-2029
IAO_0000115: The process that results in the uptake of a G protein-coupled receptor into an endocytic vesicle.
has exact synonym: G-protein coupled receptor internalization

desensitization of G protein-coupled receptor signaling pathway by arrestin
type: Class
subclass of: desensitization of G protein-coupled receptor signaling pathway
subclass of: GO_0032091
IAO_0000115: The process that inhibits the signaling function of a G protein-coupled receptor by uncoupling the receptor from its downstream G proteins.
has exact synonym: arrestin mediated desensitisation of G-protein coupled receptor protein signalling pathway
has exact synonym: arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway
has exact synonym: arrestin-mediated desensitization of G-protein coupled receptor protein signaling pathway
has exact synonym: desensitization of G-protein coupled receptor protein signaling pathway by arrestin

angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure
type: Class
subclass of: negative regulation of systemic arterial blood pressure
subclass of: GO_0042311
subclass of: part-of-parent-2034
IAO_0000115: The process that increases the diameter of a blood vessel via the renin-angiotensin system.
has exact synonym: vasodilation by angiotensin involved in regulation of systemic arterial blood pressure

maintenance of blood vessel diameter homeostasis by renin-angiotensin
type: Class
subclass of: renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure
subclass of: regulation of systemic arterial blood pressure by renin-angiotensin
subclass of: GO_0097746
IAO_0000115: The process in which the diameter of a blood vessel is changed due to activity of the renin-angiotensin system.
has exact synonym: regulation of blood vessel diameter by renin-angiotensin
has related synonym: regulation of blood vessel size by renin-angiotensin
has related synonym: renin-angiotensin regulation of blood vessel size

brain renin-angiotensin system
type: Class
subclass of: nervous system process involved in regulation of systemic arterial blood pressure
subclass of: regulation of blood volume by renin-angiotensin
IAO_0000115: The process in which an angiotensin-mediated signaling system present in the brain regulates the force with which blood passes through the circulatory system.

regulation of L-glutamate import across plasma membrane
type: Class
subclass of: GO_0010958
subclass of: GO_1903959
IAO_0000115: Any process that modulates the frequency, rate or extent of L-glutamate import into a cell.
has related synonym: regulation of L-glutamate import
has related synonym: regulation of L-glutamate transport
has exact synonym: regulation of L-glutamate uptake
replaces: GO_1900920

negative regulation of L-glutamate import across plasma membrane
type: Class
subclass of: regulation of L-glutamate import across plasma membrane
subclass of: GO_0051956
subclass of: GO_1903960
IAO_0000115: Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamate import into a cell.
has exact synonym: downregulation of L-glutamate import
has exact synonym: down regulation of L-glutamate import
has exact synonym: down-regulation of L-glutamate import
has related synonym: downregulation of L-glutamate transport
has related synonym: down regulation of L-glutamate transport
has related synonym: down-regulation of L-glutamate transport
has related synonym: downregulation of L-glutamate uptake
has related synonym: down regulation of L-glutamate uptake
has related synonym: down-regulation of L-glutamate uptake
has related synonym: inhibition of L-glutamate import
has related synonym: inhibition of L-glutamate transport
has related synonym: inhibition of L-glutamate uptake
has related synonym: negative regulation of L-glutamate import
has related synonym: negative regulation of L-glutamate transport
has related synonym: negative regulation of L-glutamate uptake
has related synonym: regulation of L-glutamate import
replaces: GO_1900921

positive regulation of L-glutamate import across plasma membrane
type: Class
subclass of: regulation of L-glutamate import across plasma membrane
subclass of: GO_0051957
subclass of: GO_1903961
IAO_0000115: Any process that activates or increases the frequency, rate or extent of L-glutamate import into a cell.
has related synonym: activation of L-glutamate import
has related synonym: activation of L-glutamate transport
has related synonym: activation of L-glutamate uptake
has related synonym: positive regulation of L-glutamate import
has related synonym: positive regulation of L-glutamate transport
has related synonym: positive regulation of L-glutamate uptake
has related synonym: stimulation of L-glutamate transport
has exact synonym: upregulation of L-glutamate import
has exact synonym: up regulation of L-glutamate import
has exact synonym: up-regulation of L-glutamate import
has related synonym: upregulation of L-glutamate transport
has related synonym: up regulation of L-glutamate transport
has exact synonym: up-regulation of L-glutamate transport
has related synonym: upregulation of L-glutamate uptake
has related synonym: up regulation of L-glutamate uptake
has related synonym: up-regulation of L-glutamate uptake
replaces: GO_1900922

p53 binding
type: Class
subclass of: GO_0005515
IAO_0000115: Binding to one of the p53 family of proteins.

sprouting angiogenesis
type: Class
subclass of: angiogenesis
IAO_0000115: The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation.

intussusceptive angiogenesis
type: Class
subclass of: angiogenesis
IAO_0000115: The formation of new blood vessels as a result of the insertion and extension of lumenal tissue pillars.

cell migration involved in sprouting angiogenesis
type: Class
subclass of: GO_0043534
subclass of: part-of-parent-2040
IAO_0000115: The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.

blood vessel endothelial cell proliferation involved in sprouting angiogenesis
type: Class
subclass of: endothelial cell proliferation
subclass of: part-of-parent-2040
IAO_0000115: The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population contributing to sprouting angiogenesis.
has related synonym: blood vessel endothelial cell proliferation during sprouting angiogenesis

blood vessel endothelial cell migration involved in intussusceptive angiogenesis
type: Class
subclass of: GO_0043534
subclass of: part-of-parent-2041
IAO_0000115: The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels during intussusceptive angiogenesis.

regulation of cell adhesion involved in intussusceptive angiogenesis
type: Class
subclass of: GO_0030155
subclass of: part-of-parent-2041
IAO_0000115: The process that modulates the frequency, rate or extent of attachment of a blood vessel endothelial cell to another cell or to the extracellular matrix involved in intussusceptive angiogenesis.

opsin binding
type: Class
subclass of: GO_0005515
IAO_0000115: Binding to an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception.
has related synonym: metarhodopsin binding
replaces: GO_0016030

phenazine biosynthetic process
type: Class
subclass of: GO_0017000
subclass of: GO_0018130
subclass of: GO_0019438
subclass of: GO_0044271
subclass of: GO_1901362
subclass of: GO_1901566
IAO_0000115: The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring.
has related synonym: acridizine biosynthesis
has related synonym: acridizine biosynthetic process
has related synonym: azophenylene biosynthesis
has related synonym: azophenylene biosynthetic process
has related synonym: dibenzo-p-diazine biosynthesis
has related synonym: dibenzo-p-diazine biosynthetic process
has related synonym: dibenzopyrazine biosynthesis
has related synonym: dibenzopyrazine biosynthetic process

pyoverdine metabolic process
type: Class
subclass of: GO_0009237
IAO_0000115: The chemical reactions and pathways involving the siderochrome pyoverdine.
has exact synonym: pyoverdine metabolism

pyoverdine biosynthetic process
type: Class
subclass of: pyoverdine metabolic process
subclass of: GO_0019290
IAO_0000115: The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine.

pyoverdine catabolic process
type: Class
subclass of: pyoverdine metabolic process
subclass of: GO_0046215
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of the siderochrome pyoverdine.

osteoblast fate commitment
type: Class
subclass of: GO_0045165
subclass of: part-of-parent-1649
IAO_0000115: The commitment of mesenchymal cells to the specific cell fate of an osteoblast. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone.

positive regulation of neuroblast proliferation
type: Class
subclass of: GO_0050769
subclass of: GO_1902692
subclass of: GO_2000179
IAO_0000115: Any process that activates or increases the rate of neuroblast proliferation.
has related synonym: activation of neuroblast proliferation
has related synonym: stimulation of neuroblast proliferation
has exact synonym: upregulation of neuroblast proliferation
has exact synonym: up regulation of neuroblast proliferation
has exact synonym: up-regulation of neuroblast proliferation

positive regulation of mesenchymal cell proliferation
type: Class
subclass of: GO_0008284
subclass of: GO_0010464
IAO_0000115: The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells.
has related synonym: activation of mesenchymal cell proliferation
has related synonym: stimulation of mesenchymal cell proliferation
has exact synonym: upregulation of mesenchymal cell proliferation
has exact synonym: up regulation of mesenchymal cell proliferation
has exact synonym: up-regulation of mesenchymal cell proliferation

nucleobase binding
type: Class
subclass of: GO_0036094
subclass of: GO_0097159
subclass of: GO_1901363
IAO_0000115: Binding to a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases.

adenine binding
type: Class
subclass of: purine nucleobase binding
IAO_0000115: Binding to adenine, a purine base.
has exact synonym: 6-aminopurine binding

cytosine binding
type: Class
subclass of: pyrimidine nucleobase binding
IAO_0000115: Binding to cytosine.

guanine binding
type: Class
subclass of: purine nucleobase binding
IAO_0000115: Binding to guanine.

uracil binding
type: Class
subclass of: pyrimidine nucleobase binding
IAO_0000115: Binding to uracil.

thymine binding
type: Class
subclass of: pyrimidine nucleobase binding
IAO_0000115: Binding to thymine.

purine nucleobase binding
type: Class
subclass of: nucleobase binding
IAO_0000115: Binding to a purine nucleobase, an organic nitrogenous base with a purine skeleton.
has exact synonym: purine base binding
has related synonym: purine binding

pyrimidine nucleobase binding
type: Class
subclass of: nucleobase binding
IAO_0000115: Binding to a pyrimidine nucleobase, an organic nitrogenous base with a pyrimidine skeleton.
has related synonym: 1,3-diazine binding
has exact synonym: pyrimidine base binding
has related synonym: pyrimidine binding

chondrocyte differentiation
type: Class
subclass of: GO_0030154
subclass of: part-of-parent-51216
IAO_0000115: The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage.

chondrocyte development
type: Class
subclass of: GO_0048468
subclass of: part-of-parent-2062
IAO_0000115: The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.

epithelial cell development
type: Class
subclass of: GO_0048468
subclass of: part-of-parent-30855
IAO_0000115: The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.

columnar/cuboidal epithelial cell differentiation
type: Class
subclass of: GO_0030855
IAO_0000115: The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.

columnar/cuboidal epithelial cell development
type: Class
subclass of: epithelial cell development
subclass of: part-of-parent-2065
IAO_0000115: The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.

glandular epithelial cell differentiation
type: Class
subclass of: columnar/cuboidal epithelial cell differentiation
IAO_0000115: The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.

glandular epithelial cell development
type: Class
subclass of: columnar/cuboidal epithelial cell development
subclass of: part-of-parent-2067
IAO_0000115: The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.

columnar/cuboidal epithelial cell maturation
type: Class
subclass of: epithelial cell maturation
subclass of: part-of-parent-2066
IAO_0000115: The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.

epithelial cell maturation
type: Class
subclass of: GO_0048469
subclass of: part-of-parent-2064
IAO_0000115: The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.

glandular epithelial cell maturation
type: Class
subclass of: columnar/cuboidal epithelial cell maturation
subclass of: part-of-parent-2068
IAO_0000115: The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.

optic cup morphogenesis involved in camera-type eye development
type: Class
subclass of: GO_0016331
subclass of: part-of-parent-60900
IAO_0000115: The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus.
has exact synonym: optic cup morphogenesis involved in camera-style eye development

extraocular skeletal muscle development
type: Class
subclass of: GO_0007519
subclass of: GO_0060538
subclass of: part-of-parent-43010
IAO_0000115: The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus.

somitomeric trunk muscle development
type: Class
subclass of: GO_0060538
IAO_0000115: The process whose specific outcome is the progression of the somitomeric trunk muscle over time, from its formation to the mature structure. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus.

osteoblast development
type: Class
subclass of: GO_0048468
subclass of: part-of-parent-1649
IAO_0000115: The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone.

acrosome matrix dispersal
type: Class
subclass of: GO_0022414
subclass of: GO_0051603
subclass of: part-of-parent-7340
IAO_0000115: The proteolytic digestion of components in the acrosomal matrix that occurs as part of the acrosome reaction. The process can occur either in the cumulus oophorous facilitating the penetration of it by the sperm, or at the zona pellucida allowing the sperm to reach the plasma membrane of the egg where the inner acrosomal membrane of the sperm can interact with the egg plasma membrane.

membrane fusion involved in acrosome reaction
type: Class
subclass of: GO_0022412
subclass of: GO_0061025
subclass of: part-of-parent-7340
IAO_0000115: The fusion of the plasma membrane of the sperm with the outer acrosomal membrane.
has exact synonym: membrane fusion involved in the acrosomal reaction

inner acrosomal membrane
type: Class
subclass of: GO_0030659
subclass of: part-of-parent-2080
IAO_0000115: The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane.

acrosomal membrane
type: Class
subclass of: GO_0030667
subclass of: part-of-parent-1669
IAO_0000115: The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization.

outer acrosomal membrane
type: Class
subclass of: GO_0030659
subclass of: part-of-parent-2080
IAO_0000115: The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction.

regulation of oxidative phosphorylation
type: Class
subclass of: GO_1903715
IAO_0000115: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.
has exact synonym: OXPHOS

4-hydroxybenzoate decaprenyltransferase activity
type: Class
subclass of: polyprenyltransferase activity
IAO_0000115: Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 3-decaprenyl-4-hydroxybenzoate + diphosphate.

protein depalmitoylation
type: Class
subclass of: GO_0035601
subclass of: GO_0042159
subclass of: GO_0098734
IAO_0000115: The removal of palymitoyl groups from a lipoprotein.

inhibition of neuroepithelial cell differentiation
type: Class
subclass of: GO_0022603
subclass of: GO_0030857
subclass of: GO_0045995
subclass of: GO_0048505
IAO_0000115: Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells.
has related synonym: negative regulation of neural plate formation
has related synonym: repression of premature neural plate formation

diaphragm contraction
type: Class
subclass of: involuntary skeletal muscle contraction
subclass of: respiratory system process
IAO_0000115: A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. This process occurs in the diaphragm. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The diaphragm is a striated muscle that is necessary for the process of respiratory gaseous exchange.

regulation of respiratory gaseous exchange by nervous system process
type: Class
subclass of: GO_0044065
subclass of: GO_0050877
IAO_0000115: A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates.
has exact synonym: neurological control of breathing
has exact synonym: regulation of respiratory gaseous exchange by neurological system process

lens development in camera-type eye
type: Class
subclass of: GO_0048856
subclass of: part-of-parent-43010
IAO_0000115: The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
has exact synonym: lens development
has exact synonym: lens development in camera-style eye

lens morphogenesis in camera-type eye
type: Class
subclass of: GO_0009653
subclass of: part-of-parent-2088
subclass of: part-of-parent-48593
IAO_0000115: The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
has exact synonym: lens morphogenesis
has exact synonym: lens morphogenesis in camera-style eye

regulation of receptor internalization
type: Class
subclass of: GO_0048259
IAO_0000115: Any process that modulates the frequency, rate or extent of receptor internalization.

negative regulation of receptor internalization
type: Class
subclass of: regulation of receptor internalization
subclass of: GO_0048261
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of receptor internalization.
has exact synonym: downregulation of receptor internalization
has exact synonym: down regulation of receptor internalization
has exact synonym: down-regulation of receptor internalization
has related synonym: inhibition of receptor internalization

positive regulation of receptor internalization
type: Class
subclass of: regulation of receptor internalization
subclass of: GO_0048260
IAO_0000115: Any process that activates or increases the frequency, rate or extent of receptor internalization.
has related synonym: activation of receptor internalization
has related synonym: stimulation of receptor internalization
has exact synonym: upregulation of receptor internalization
has exact synonym: up regulation of receptor internalization
has exact synonym: up-regulation of receptor internalization

auditory receptor cell morphogenesis
type: Class
subclass of: GO_0048598
subclass of: GO_0048667
subclass of: part-of-parent-42472
subclass of: part-of-parent-60117
IAO_0000115: Any process that alters the size or shape of an auditory receptor cell.
has related synonym: hair cell morphogenesis

polyprenyltransferase activity
type: Class
subclass of: prenyltransferase activity
IAO_0000115: Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor).

caveolar macromolecular signaling complex
type: Class
subclass of: GO_0098797
subclass of: part-of-parent-5901
IAO_0000115: A complex composed of proteins required for beta adrenergic receptor activation of protein kinase A. It includes the Cav 12. subunit of L-type calcium channel, protein kinase A regulatory subunit 2(PKAR2), adenyl cyclase, beta-adrenergic receptor, G-alpha-S, protein phosphatase 2A (PP2A) and caveolin 3 (CAV3).
has exact synonym: caveolar macromolecular signalling complex

polkadots
type: Class
subclass of: GO_0032991
subclass of: part-of-parent-5737
IAO_0000115: A punctate, filamentous structure composed of Bcl10 that appears in the cytoplasm of T-cells shortly after T-cell receptor stimulation. Polkadots stands for Punctate Oligomeric Killing and Activating DOmains Transducing Signals.

tRNA wobble base modification
type: Class
subclass of: GO_0006400
IAO_0000115: The process in which the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally modified.

tRNA wobble uridine modification
type: Class
subclass of: tRNA wobble base modification
IAO_0000115: The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified.

tRNA wobble guanine modification
type: Class
subclass of: tRNA wobble base modification
IAO_0000115: The process in which a guanine in t position 34 of a tRNA is post-transcriptionally modified.

tRNA wobble adenosine to inosine editing
type: Class
subclass of: tRNA wobble base modification
subclass of: GO_0006382
IAO_0000115: The process in which an adenosine in position 34 of a tRNA is post-transcriptionally converted to inosine.

tRNA wobble cytosine modification
type: Class
subclass of: tRNA wobble base modification
IAO_0000115: The process in which a cytosine in position 34 of a tRNA is post-transcriptionally modified.

podosome
type: Class
subclass of: GO_0043232
subclass of: part-of-parent-15629
IAO_0000115: An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.

endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
type: Class
subclass of: endonucleolytic cleavage involved in rRNA processing
IAO_0000115: Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the chloroplasts of vascular plants. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.

endonucleolytic cleaveage between 4.5S rRNA and 5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
type: Class
subclass of: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
IAO_0000115: Endonucleolytic cleavage between the 5S rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.

endonucleolytic cleaveage between LSU-rRNA and 4.5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
type: Class
subclass of: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
IAO_0000115: Endonucleolytic cleavage between the LSU-rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.

endonucleolytic cleaveage between SSU-rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
type: Class
subclass of: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
IAO_0000115: Endonucleolytic cleavages between the SSU-rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. These cleavages liberate tRNAs from the polycistronic transcript as well as separating the SSU and LSU containing transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.

generation of mature 3'-end of 5S rRNA generated by RNA polymerase III
type: Class
subclass of: maturation of 5S rRNA
subclass of: GO_0031125
IAO_0000115: The removal of extra uridine residues from the 3' end of a 5S pre-rRNA generated by transcription by RNA polymerase III to generate the mature 3'-end.

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)
type: Class
subclass of: maturation of LSU-rRNA
IAO_0000115: Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript.

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)
type: Class
subclass of: GO_0030490
IAO_0000115: Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript.

cotranscriptional mitochondrial rRNA nucleotide insertion
type: Class
subclass of: rRNA modification
subclass of: GO_0070705
IAO_0000115: The insertion of one or two non-coded nucleotides during the transcription of a mitochondrial rRNA. Such additions are known to occur in myxomycetes such as Physarum, Didymium, and Stemonitis.

BRCA2-BRAF35 complex
type: Class
subclass of: GO_0140513
IAO_0000115: A heterodimeric complex of BRCA2 and BRAF35 (BRCA2-associated factor 35). The BRCA2-BRAF35 complex is often associated with condensed chromatin during mitosis.

interleukin-33 receptor binding
type: Class
subclass of: GO_0005126
IAO_0000115: Binding to an interleukin-33 receptor.
has related synonym: IL-33
has related synonym: interleukin-33 receptor ligand

interleukin-33 binding
type: Class
subclass of: GO_0019955
IAO_0000115: Binding to interleukin-33.
has exact synonym: IL-33 binding

interleukin-33 receptor activity
type: Class
subclass of: GO_0004896
subclass of: part-of-parent-38172
IAO_0000115: Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has exact synonym: IL-33R
has exact synonym: IL-33 receptor activity

store-operated calcium entry
type: Class
subclass of: GO_0006816
IAO_0000115: A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum.
has related synonym: calcium ion import
has exact synonym: capacitative calcium entry
has exact synonym: SOCE
has exact synonym: store-operated calcium import

semaphorin receptor complex
type: Class
subclass of: GO_0043235
IAO_0000115: A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor.
has exact synonym: plexin-neurophilin complex

amphibian larval development
type: Class
subclass of: larval development
IAO_0000115: The process whose specific outcome is the progression of the amphibian larva over time, from its formation to the mature structure. Amphibian larvae, sometimes called pollywogs or tadpoles, hatch from eggs and begin to grow limbs and other adult physical features at various times, depending on the species, before they metamorphose into the adult form.

aggressive behavior
type: Class
subclass of: GO_0007610
IAO_0000115: A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual.
has exact synonym: aggression

nematode larval development
type: Class
subclass of: larval development
IAO_0000115: The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.

obsolete predatory behavior
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Aggressive behavior involving attack on prey by a predator.

inter-male aggressive behavior
type: Class
subclass of: aggressive behavior
IAO_0000115: Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious.
has exact synonym: inter-male aggression

fear-induced aggressive behavior
type: Class
subclass of: aggressive behavior
IAO_0000115: Aggressive behavior associated with attempts to flee from a threat.
has exact synonym: fear-induced aggression

irritable aggressive behavior
type: Class
subclass of: aggressive behavior
IAO_0000115: Aggressive behavior induced by frustration and directed against an available target.
has exact synonym: irritable aggression

territorial aggressive behavior
type: Class
subclass of: aggressive behavior
IAO_0000115: Aggressive behavior performed in defence of a fixed area against intruders, typically conspecifics.
has exact synonym: territorial aggression

maternal aggressive behavior
type: Class
subclass of: aggressive behavior
IAO_0000115: Aggressive behavior of a female to protect her offspring from a threat.
has exact synonym: maternal aggression

instrumental aggressive behavior
type: Class
subclass of: aggressive behavior
IAO_0000115: Aggressive behavior directed towards obtaining some goal, considered to be a learned response to a situation.
has exact synonym: instrumental aggression

tRNA wobble base cytosine methylation
type: Class
subclass of: tRNA wobble cytosine modification
subclass of: tRNA C5-cytosine methylation
IAO_0000115: The process in which the base of cytosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the C5 position.
has exact synonym: wobble position m5C biosynthesis

tRNA nucleoside ribose methylation
type: Class
subclass of: GO_0030488
IAO_0000115: The process that results in the modification of the sugar of a nucleoside in tRNA at the 2'O position.

wobble position guanine ribose methylation
type: Class
subclass of: wobble position ribose methylation
subclass of: tRNA guanine ribose methylation
IAO_0000115: The process in which the ribose of guanosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position.

wobble position ribose methylation
type: Class
subclass of: tRNA nucleoside ribose methylation
IAO_0000115: The process in which the ribose base of the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'O position.

wobble position cytosine ribose methylation
type: Class
subclass of: wobble position ribose methylation
IAO_0000115: The process in which the ribose of cytidine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position.

wobble position uridine ribose methylation
type: Class
subclass of: wobble position ribose methylation
IAO_0000115: The process in which the ribose of uridine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position.

polycystin complex
type: Class
subclass of: GO_0032991
IAO_0000115: A stable heterodimeric complex composed of polycystin-1 and polycystin-2.

UTP binding
type: Class
subclass of: GO_0032557
subclass of: GO_0043168
IAO_0000115: Binding to UTP, uridine 5'-triphosphate.

CTP binding
type: Class
subclass of: GO_0032557
subclass of: GO_0043168
IAO_0000115: Binding to CTP, cytidine 5'-triphosphate.

tRNA wobble base lysidine biosynthesis
type: Class
subclass of: tRNA wobble cytosine modification
IAO_0000115: The process in which the carbonyl of cytosine at position 34 of a tRNA is post-transcriptionally replaced by lysine.

retinoic acid biosynthetic process
type: Class
subclass of: GO_0016102
subclass of: GO_0042573
subclass of: GO_0072330
IAO_0000115: The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.
has exact synonym: retinoic acid anabolic process

stereocilia coupling link
type: Class
subclass of: GO_0110165
subclass of: part-of-parent-32421
IAO_0000115: A structure involved in coupling stereocilia to one another in sensory hair cells There are four morphologically distinct types: tip links, horizontal top connectors, shaft connectors and ankle links. Tip links and horizontal top connectors are the only inter-stereocilia links associated with mature cochlea, whereas ankle links appear during development of the auditory hair bundle.

stereocilia tip link
type: Class
subclass of: stereocilia coupling link
IAO_0000115: A stereocilia link that is formed by a fine filament running more or less vertically upward from the tip of each shorter stereocilium to attach at a higher point on its adjacent taller neighbor. Tilting the bundle puts tension on the filaments, which pull on mechanically gated ion channels in the membrane of the stereocilia.

stereocilia ankle link
type: Class
subclass of: stereocilia coupling link
IAO_0000115: A stereocilia coupling link that is composed of a fine filament present in developing stereocilia that couples the bases of individual stereocilia to one another. They are not present in mature stereocilia.

stereocilia ankle link complex
type: Class
subclass of: GO_0032991
subclass of: part-of-parent-2141
IAO_0000115: A complex of proteins that connect growing stereocilia in developing cochlear hair cells, composed of Vlgr1, usherin, vezatin, and whirlin.

tRNA wobble position uridine thiolation
type: Class
subclass of: tRNA wobble uridine modification
subclass of: GO_0034227
IAO_0000115: The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.
has exact synonym: tRNA wobble uridine thiolation
has exact synonym: wobble position s2U biosynthesis

cytosolic tRNA wobble base thiouridylase complex
type: Class
subclass of: GO_0140535
subclass of: GO_1902494
subclass of: part-of-parent-5829
IAO_0000115: A complex of two proteins involved in the thiolation of uridine 34 (U34) of tRNAs decoding two-family box triplets.
has related synonym: Cut1-Cut2 complex
has related synonym: tRNA thiouridylase

4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity
type: Class
subclass of: GO_0016462
IAO_0000115: Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate + H2O = hydroxymethylpyrimidine phosphate + phosphate + H(+).
has exact synonym: HMP-PP diphosphatase
has exact synonym: HMP-PP pyrophosphatase

obsolete steroid hormone receptor import into nucleus
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The directed movement of a steroid hormone receptor into the nucleus.

obsolete glucocorticoid receptor import into nucleus
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The directed movement of a glucocorticoid receptor into the nucleus.

hypochlorous acid metabolic process
type: Class
subclass of: GO_0043436
subclass of: GO_0072593
IAO_0000115: The chemical reactions and pathways involving hypochlorous acid.
has exact synonym: HClO metabolic process
has exact synonym: HOCl metabolic process
has related synonym: hypochlorite metabolic process
has exact synonym: hypochlorous acid metabolism

hypochlorous acid biosynthetic process
type: Class
subclass of: hypochlorous acid metabolic process
subclass of: GO_0044283
subclass of: GO_1903409
IAO_0000115: The chemical reactions and pathways resulting in the formation of hypochlorous acid.
has exact synonym: HClO biosynthetic process
has exact synonym: HOCl biosynthetic process
has related synonym: hypochlorite biosynthetic process
has exact synonym: hypochlorous acid biosynthesis

hypochlorous acid catabolic process
type: Class
subclass of: hypochlorous acid metabolic process
subclass of: GO_0044282
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of hypochlorous acid.
has exact synonym: HClO catabolic process
has exact synonym: HOCl catabolic process
has related synonym: hypochlorite catabolic process
has exact synonym: hypochlorous acid catabolism

G-quadruplex RNA binding
type: Class
subclass of: RNA binding
IAO_0000115: Binding to a G-quadruplex RNA structure, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad.
has exact synonym: G quadruplex binding
has related synonym: G quartet binding
has related synonym: G-quartet binding
has exact synonym: G quartet RNA binding

bile acid conjugation
type: Class
subclass of: GO_0008206
IAO_0000115: The process in which bile acids are covalently linked to taurine or glycine.

steroid receptor RNA activator RNA binding
type: Class
subclass of: single-stranded RNA binding
IAO_0000115: Binding to a steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding.
has exact synonym: SRA binding

thyroid hormone mediated signaling pathway
type: Class
subclass of: GO_0009755
subclass of: GO_0030522
IAO_0000115: The series of molecular signals mediated by the detection of a thyroid hormone.
has exact synonym: thyroid hormone mediated signalling pathway

regulation of thyroid hormone mediated signaling pathway
type: Class
subclass of: GO_0009966
IAO_0000115: Any process that modulates the frequency, rate or extent of a thyroid hormone mediated signaling pathway.
has exact synonym: regulation of thyroid hormone mediated signalling pathway

negative regulation of thyroid hormone mediated signaling pathway
type: Class
subclass of: regulation of thyroid hormone mediated signaling pathway
subclass of: GO_0009968
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of thyroid hormone mediated signaling pathway.
has exact synonym: negative regulation of thyroid hormone mediated signalling pathway

positive regulation of thyroid hormone mediated signaling pathway
type: Class
subclass of: regulation of thyroid hormone mediated signaling pathway
subclass of: GO_0009967
IAO_0000115: Any process that increases the frequency, rate or extent of thyroid hormone mediated signaling pathway.
has exact synonym: positive regulation of thyroid hormone mediated signalling pathway

osteoclast proliferation
type: Class
subclass of: GO_0070661
IAO_0000115: The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes.

desmosome assembly
type: Class
subclass of: desmosome organization
subclass of: GO_0007043
IAO_0000115: A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.

desmosome maintenance
type: Class
subclass of: desmosome organization
subclass of: GO_0045217
IAO_0000115: The maintenance of a desmosome. A desmosome is a patch-like intercellular junctions found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an interspace of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.

aminoacyl-tRNA editing activity
type: Class
subclass of: GO_0052689
subclass of: GO_0140101
subclass of: part-of-parent-106074
IAO_0000115: The hydrolysis of an incorrectly aminoacylated tRNA.
has related synonym: amino acid proofreading activity
has related synonym: aminoacyl-tRNA hydrolysis activity

dystroglycan binding
type: Class
subclass of: GO_0005515
IAO_0000115: Binding to dystroglycan, a glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal).
has related synonym: alpha-dystroglycan binding
has related synonym: beta-dystroglycan binding
replaces: GO_0002163
replaces: GO_0002166

larval development
type: Class
subclass of: GO_0007275
subclass of: GO_0009791
IAO_0000115: The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters.

instar larval or pupal development
type: Class
subclass of: GO_0007275
subclass of: GO_0009791
IAO_0000115: The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster.

VRK3/VHR/ERK complex
type: Class
subclass of: GO_0032991
IAO_0000115: A ternary complex consisting of VRK3, VHR (Dusp3), and ERK1 (Mapk3) existing in neuronal cells, and is involved in regulation of the ERK signaling pathway.

instar larval development
type: Class
subclass of: larval development
subclass of: instar larval or pupal development
IAO_0000115: The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster.

3-methylcrotonyl-CoA carboxylase complex, mitochondrial
type: Class
subclass of: GO_0098798
subclass of: GO_1905202
IAO_0000115: A mitochondrial protein complex which is capable of 3-methylcrotonyl-CoA carboxylase activity. In mammals, at least, consists as a dodecamer of 6 alpha and 6 beta subunits. MCCC-alpha has a covalently bound biotin essential for the ATP-dependent carboxylation. MCCC-beta possesses carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA.
has exact synonym: mitochondrial 3-methylcrotonyl-CoA carboxylase holoenzyme
has exact synonym: mitochondrial MCCC complex
has exact synonym: mitochondrial methylcrotonoyl-CoA carboxylase complex

high-affinity IgA receptor activity
type: Class
subclass of: GO_0019766
IAO_0000115: Combining with high affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has exact synonym: high affinity IgA receptor activity

low-affinity IgA receptor activity
type: Class
subclass of: GO_0019766
IAO_0000115: Combining with low affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has exact synonym: low affinity IgA receptor activity

high-affinity IgM receptor activity
type: Class
subclass of: IgM receptor activity
IAO_0000115: Combining with high affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has exact synonym: high affinity IgM receptor activity

low-affinity IgM receptor activity
type: Class
subclass of: IgM receptor activity
IAO_0000115: Combining with low affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has exact synonym: low affinity IgM receptor activity

mammary stem cell proliferation
type: Class
subclass of: GO_0008283
subclass of: part-of-parent-30879
IAO_0000115: The expansion of a mammary stem cell population by cell division. Mammary stem cells are a source of cells for growth of the mammary gland during puberty and gestation. These cells can give rise to both the luminal and myoepithelial cell types of the gland, and can regenerate the entire organ.

protein localization to paranode region of axon
type: Class
subclass of: GO_0099612
IAO_0000115: A cellular protein localization process in which a protein is transported to, or maintained at, the paranode region of an axon.
has exact synonym: protein localisation to paranode region of axon

male germ cell proliferation
type: Class
subclass of: GO_0036093
IAO_0000115: The multiplication or reproduction of male germ cells, resulting in the expansion of a cell population.

manchette
type: Class
subclass of: GO_0110165
subclass of: part-of-parent-15630
IAO_0000115: A tubular array of microtubules that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme. The manchette may also contain F-actin filaments.

palmitoyltransferase complex
type: Class
subclass of: GO_1990234
IAO_0000115: A protein complex with palmitoyltransferase activity.

homodimeric serine palmitoyltransferase complex
type: Class
subclass of: GO_0017059
IAO_0000115: A homodimeric complex which transfers a palmitoyl group onto serine, forming 3-dehydro-D-sphinganine.

5-lipoxygenase complex
type: Class
subclass of: GO_0098796
subclass of: GO_0140513
subclass of: GO_1990204
subclass of: part-of-parent-31965
IAO_0000115: An nuclear membrane protein complex having arachidonate 5-lipoxygenase activity.

cytoplasmic translation
type: Class
subclass of: GO_0006412
IAO_0000115: The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.

cytoplasmic translational elongation
type: Class
subclass of: GO_0006414
subclass of: part-of-parent-2181
IAO_0000115: The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm.

cytoplasmic translational initiation
type: Class
subclass of: GO_0006413
subclass of: part-of-parent-2181
IAO_0000115: The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.

cytoplasmic translational termination
type: Class
subclass of: GO_0006415
subclass of: part-of-parent-2181
IAO_0000115: The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon.

creatine kinase complex
type: Class
subclass of: GO_0061695
IAO_0000115: A protein complex having creatine kinase activity.

cytosolic creatine kinase complex
type: Class
subclass of: creatine kinase complex
subclass of: part-of-parent-5829
IAO_0000115: A dimeric protein complex having creatine kinase activity.

mitochondrial creatine kinase complex
type: Class
subclass of: creatine kinase complex
subclass of: GO_0098798
subclass of: part-of-parent-5739
IAO_0000115: An octomeric protein complex having creatine kinase activity.

translation reinitiation
type: Class
subclass of: cytoplasmic translational initiation
IAO_0000115: A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon.

ribose phosphate diphosphokinase complex
type: Class
subclass of: GO_0061695
IAO_0000115: A protein complex having ribose phosphate diphosphokinase activity.
has exact synonym: phosphoribosylpyrophosphate synthetase complex
has exact synonym: PRPP synthetase complex

cap-independent translational initiation
type: Class
subclass of: cytoplasmic translational initiation
IAO_0000115: The process where translation initiation recruits the 40S ribosomal subunits in a Cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate mRNA or circRNA translation.

cap-dependent translational initiation
type: Class
subclass of: cytoplasmic translational initiation
IAO_0000115: The process where the cap structure, composed of a 7- methylguanosine (m7G) group and associated cap-binding proteins, located at the 5' end of an mRNA molecule, which serves as a molecular tag that marks the spot where the 40S ribosomal subunit, is recruited and will then scan in a 5' to 3' direction until an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation.

IRES-dependent translational initiation of linear mRNA
type: Class
subclass of: GO_0110017
IAO_0000115: The process where translation initiation recruits the 40S ribosomal subunits via an internal ribosome entry segment (IRES) before an AUG codon is encountered in an appropriate sequence context to initiate linear mRNA translation.

MAML1-RBP-Jkappa- ICN1 complex
type: Class
subclass of: GO_0032991
IAO_0000115: A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
has exact synonym: MAML1-CSL-ICN1
has exact synonym: MAML1-CSL-Notch1 complex
has exact synonym: MAML1-RBP-Jkappa-Notch1 complex

hepatocyte cell migration
type: Class
subclass of: GO_0016477
IAO_0000115: The orderly movement of a hepatocyte during the development of the liver. Hepatocytes emerge from the hepatic epithelium, populating the septum transversum and lateral mesenchymal areas of the hepatic lobes.

2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine-tRNA biosynthesis
type: Class
subclass of: GO_0006400
IAO_0000115: The chemical reactions and pathways involved in the biosynthesis of 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine (ms2io6A), a modified nucleoside present in position 37 (adjacent to and 3' of the anticodon) of tRNAs.

Ser-tRNA(Ala) hydrolase activity
type: Class
subclass of: aminoacyl-tRNA editing activity
IAO_0000115: Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala).

xanthine dehydrogenase complex
type: Class
subclass of: GO_1990204
IAO_0000115: A homodimeric protein complex having xanthine dehydrogenase activity.

obsolete S/G2 transition of mitotic cell cycle
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The transition from a cell in the S phase to the G2 phase.

zona pellucida receptor complex
type: Class
subclass of: GO_0032991
IAO_0000115: A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction.
has related synonym: sperm protein complex I

somatic diversification of immune receptors
type: Class
subclass of: immune system process
subclass of: part-of-parent-2520
IAO_0000115: The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences.

somatic diversification of DSCAM-based immune receptors
type: Class
subclass of: somatic diversification of immune receptors
IAO_0000115: The somatic process that results in the generation of sequence diversity of the DSCAM-based immune receptors of insects.

somatic diversification of variable lymphocyte receptors of jawless fish
type: Class
subclass of: somatic diversification of immune receptors
IAO_0000115: The somatic process that results in the generation of sequence diversity of the variable lymphocyte receptors (VLR) of jawless fish.

proteolysis by cytosolic proteases associated with antigen processing and presentation
type: Class
subclass of: proteolysis associated with antigen processing and presentation
IAO_0000115: The hydrolysis of a peptide bond or bonds within a protein by cytosolic resident proteases during antigen processing and presentation.

somatic recombination of immunoglobulin genes involved in immune response
type: Class
subclass of: somatic diversification of immunoglobulins involved in immune response
subclass of: GO_0016447
IAO_0000115: The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response.
has related synonym: somatic recombination of antibody genes during immune response
has related synonym: somatic recombination of immunoglobulin genes during immune response

somatic hypermutation of immunoglobulin genes involved in immune response
type: Class
subclass of: somatic diversification of immunoglobulins involved in immune response
subclass of: GO_0016446
subclass of: part-of-parent-2344
IAO_0000115: Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins following the induction of and contributing to an immune response.
has related synonym: somatic hypermutation of antibody genes during immune response
has related synonym: somatic hypermutation of immunoglobulin genes during immune response

gene conversion of immunoglobulin genes
type: Class
subclass of: somatic diversification of immune receptors via gene conversion
subclass of: GO_0016445
subclass of: GO_0035822
IAO_0000115: The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion.
has exact synonym: gene conversion of antibody genes

gene conversion of immunoglobulin genes involved in immune response
type: Class
subclass of: gene conversion of immunoglobulin genes
subclass of: somatic diversification of immunoglobulins involved in immune response
IAO_0000115: The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion following the induction of and contributing to an immune response.
has related synonym: gene conversion of antibody genes during immune response
has related synonym: gene conversion of immunoglobulin genes during immune response

somatic diversification of immunoglobulins involved in immune response
type: Class
subclass of: GO_0016445
subclass of: part-of-parent-2381
IAO_0000115: The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response.
has related synonym: somatic diversification of antibodies during immune response
has related synonym: somatic diversification of immunoglobulins during immune response

behavioral defense response
type: Class
subclass of: GO_0006952
subclass of: GO_0007610
IAO_0000115: A behavioral response seeking to protect an organism from an a perceived external threat to that organism.
has exact synonym: behavioural defense response

behavioral response to wounding
type: Class
subclass of: GO_0007610
subclass of: GO_0009611
IAO_0000115: A behavioral response resulting from wounding.
has exact synonym: behavioural response to wounding

behavioral defense response to insect
type: Class
subclass of: behavioral defense response
subclass of: defense response to insect
IAO_0000115: A behavioral response seeking to protect an organism from an a perceived external threat from an insect or insects to that organism.
has exact synonym: behavioural defense response to insect

behavioral defense response to nematode
type: Class
subclass of: behavioral defense response
subclass of: defense response to nematode
IAO_0000115: A behavioral response seeking to protect an organism from an a perceived external threat from a nematode or nematodes to that organism.
has exact synonym: behavioural defense response to nematode

defense response to insect
type: Class
subclass of: GO_0098542
IAO_0000115: A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism.
has exact synonym: physiological defense response to insect
replaces: GO_0002214

defense response to nematode
type: Class
subclass of: GO_0098542
IAO_0000115: A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
has exact synonym: physiological defense response to nematode
replaces: GO_0002216

activation of innate immune response
type: Class
subclass of: activation of immune response
subclass of: GO_0045089
IAO_0000115: Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.
replaces: GO_0002219

innate immune response activating cell surface receptor signaling pathway
type: Class
subclass of: immune response-activating cell surface receptor signaling pathway
subclass of: innate immune response-activating signal transduction
IAO_0000115: The series of molecular signals initiated by a ligand binding to a cell surface receptor that leads to the activation of an innate immune response.
has exact synonym: activation of innate immune response by cell surface receptor signaling pathway
has exact synonym: innate immune response activating cell surface receptor signalling pathway

pattern recognition receptor signaling pathway
type: Class
subclass of: immune response-regulating signaling pathway
IAO_0000115: The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells.
has exact synonym: PAMP receptor signaling pathway
has exact synonym: pathogen receptor signaling pathway
has exact synonym: pathogen receptor signalling pathway
has exact synonym: PRR signaling pathway

stimulatory killer cell immunoglobulin-like receptor signaling pathway
type: Class
subclass of: innate immune response activating cell surface receptor signaling pathway
IAO_0000115: The series of molecular signals initiated by a ligand binding to a killer cell immunoglobulin-like receptor capable of cellular activation.
has exact synonym: stimulatory killer cell immunoglobulin-like receptor signalling pathway
has exact synonym: stimulatory KIR signaling pathway

stimulatory C-type lectin receptor signaling pathway
type: Class
subclass of: innate immune response activating cell surface receptor signaling pathway
subclass of: GO_1990858
IAO_0000115: The series of molecular signals initiated by the binding of C-type lectin to its receptor on the surface of a target cell, and resulting in cellular activation.
has exact synonym: stimulatory C-type lectin receptor signalling pathway
has related synonym: stimulatory Ly49 family receptor signaling pathway

toll-like receptor signaling pathway
type: Class
subclass of: pattern recognition receptor signaling pathway
IAO_0000115: The series of molecular signals initiated by a ligand binding to a toll-like receptor on the surface of a target cell. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response.
has exact synonym: TLR signaling pathway
has exact synonym: toll-like receptor signalling pathway

positive regulation of antimicrobial peptide production
type: Class
subclass of: positive regulation of production of molecular mediator of immune response
subclass of: positive regulation of antimicrobial humoral response
subclass of: regulation of antimicrobial peptide production
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production.
has related synonym: activation of antimicrobial peptide production
has exact synonym: antimicrobial peptide induction
has related synonym: stimulation of antimicrobial peptide production
has exact synonym: upregulation of antimicrobial peptide production
has exact synonym: up regulation of antimicrobial peptide production
has exact synonym: up-regulation of antimicrobial peptide production

innate immune response in mucosa
type: Class
subclass of: mucosal immune response
subclass of: GO_0045087
IAO_0000115: Any process of the innate immune response that takes place in the mucosal tissues.

natural killer cell mediated immunity
type: Class
subclass of: lymphocyte mediated immunity
subclass of: GO_0045087
IAO_0000115: The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines.
has exact synonym: NK cell mediated immunity

defense response to oomycetes
type: Class
subclass of: response to oomycetes
subclass of: GO_0098542
IAO_0000115: Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism.

positive regulation of defense response to virus by host
type: Class
subclass of: GO_0050691
IAO_0000115: Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
has related synonym: activation of antiviral response by host
has exact synonym: positive regulation of antiviral response by host
has related synonym: stimulation of antiviral response by host
has exact synonym: upregulation of antiviral response by host
has exact synonym: up regulation of antiviral response by host
has exact synonym: up-regulation of antiviral response by host

detection of oomycetes
type: Class
subclass of: response to oomycetes
subclass of: GO_0098543
IAO_0000115: The series of events in which a stimulus from an oomycetes is received and converted into a molecular signal.

leukocyte chemotaxis involved in inflammatory response
type: Class
subclass of: leukocyte migration involved in inflammatory response
subclass of: GO_0030595
subclass of: part-of-parent-6954
IAO_0000115: The movement of an immune cell in response to an external stimulus contributing to an inflammatory response.
has related synonym: immune cell chemotaxis during inflammatory response
has related synonym: leucocyte chemotaxis during inflammatory response
has related synonym: leukocyte chemotaxis during inflammatory response

leukocyte chemotaxis involved in immune response
type: Class
subclass of: leukocyte migration involved in immune response
subclass of: GO_0030595
subclass of: part-of-parent-6955
IAO_0000115: The movement of an immune cell in response to an external stimulus a part of an immune response.
has exact synonym: immune cell chemotaxis during immune response
has exact synonym: leucocyte chemotaxis during immune response

detection of endoplasmic reticulum overloading
type: Class
subclass of: GO_0006983
subclass of: GO_0009595
IAO_0000115: The series of events in which a stimulus generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum is received and converted into a molecular signal.
has exact synonym: detection of ER overloading

detection of unfolded protein
type: Class
subclass of: GO_0006986
subclass of: GO_0009593
IAO_0000115: The series of events in which an unfolded protein stimulus is received and converted into a molecular signal.

detection of misfolded protein
type: Class
subclass of: GO_0009593
subclass of: GO_0051788
IAO_0000115: The series of events in which a misfolded protein stimulus is received and converted into a molecular signal.

response to molecule of bacterial origin
type: Class
subclass of: GO_0010033
subclass of: GO_0043207
subclass of: part-of-parent-9617
IAO_0000115: Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin.
has exact synonym: response to bacteria associated molecule
has exact synonym: response to bacterial associated molecule
has exact synonym: response to bacterium associated molecule

response to molecule of fungal origin
type: Class
subclass of: GO_0010033
subclass of: GO_0043207
subclass of: part-of-parent-9620
IAO_0000115: Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide.
has exact synonym: response to fungus associated molecule

response to oomycetes
type: Class
subclass of: GO_0051707
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an oomycetes.

response to molecule of oomycetes origin
type: Class
subclass of: GO_0010033
subclass of: GO_0043207
subclass of: part-of-parent-2239
IAO_0000115: Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin.
has exact synonym: response to oomycetes associated molecule

response to parasitic plant
type: Class
subclass of: GO_0009608
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a parasitic plant.

defense response to parasitic plant
type: Class
subclass of: response to parasitic plant
subclass of: GO_0098542
IAO_0000115: Reactions triggered in response to the presence of a parasitic plant that act to protect an organism.

detection of parasitic plant
type: Class
subclass of: response to parasitic plant
subclass of: GO_0009602
IAO_0000115: The series of events in which a stimulus from a parasitic plant is received and converted into a molecular signal.

hematopoietic progenitor cell differentiation
type: Class
subclass of: GO_0030154
subclass of: part-of-parent-30097
IAO_0000115: The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.
has exact synonym: haematopoietic progenitor cell differentiation
has exact synonym: haemopoietic progenitor cell differentiation
has exact synonym: hemopoietic progenitor cell differentiation

wound healing involved in inflammatory response
type: Class
subclass of: GO_0042060
subclass of: part-of-parent-6954
subclass of: part-of-parent-90594
IAO_0000115: The series of events that restore integrity to damaged tissue that contribute to an inflammatory response.
has related synonym: healing during inflammatory response
has related synonym: inflammatory response wound healing

clearance of damaged tissue involved in inflammatory response wound healing
type: Class
subclass of: GO_0048771
subclass of: part-of-parent-2246
IAO_0000115: The series of events leading to removal of necrotic debris that contribute to an inflammatory response.
has related synonym: clearance of damaged tissue during inflammatory response

connective tissue replacement involved in inflammatory response wound healing
type: Class
subclass of: GO_0097709
subclass of: part-of-parent-2246
IAO_0000115: The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared that contribute to an inflammatory response.
has related synonym: connective tissue replacement during inflammatory response
has related synonym: fibrosis during inflammatory response

lymphocyte anergy
type: Class
subclass of: tolerance induction
IAO_0000115: Any process contributing to lymphocyte anergy, a state of functional inactivation.

adaptive immune response
type: Class
subclass of: GO_0006955
IAO_0000115: An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
has exact synonym: acquired immune response
has exact synonym: immune memory response

organ or tissue specific immune response
type: Class
subclass of: GO_0006955
IAO_0000115: An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues.
has exact synonym: immune response in organ or tissue

immune effector process
type: Class
subclass of: immune system process
IAO_0000115: Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation.

activation of immune response
type: Class
subclass of: immune system process
subclass of: GO_0050778
IAO_0000115: Any process that initiates an immune response.

kinin cascade
type: Class
subclass of: acute inflammatory response
subclass of: GO_0072376
IAO_0000115: A series of reactions that takes place outside the cell that occur as a result of by-products of tissue damage, including collagen, cartilage, and basement membrane. The ultimate product of the kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability.

tissue kallikrein-kinin cascade
type: Class
subclass of: kinin cascade
IAO_0000115: A series of reactions that takes place outside the cell initiated by the action of tissue (glandular) kallikreins on low molecular weight kininogen in response to tissue damage. Tissue kallikreins are present in glandular tissues and their fluids, such as the salivary glands, sweat glands, pancreas, and kidney. The ultimate products of the tissue kallikrein-kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability.
has exact synonym: glandular kallikrein-kinin cascade

regulation of kinin cascade
type: Class
subclass of: regulation of acute inflammatory response
subclass of: GO_2000257
IAO_0000115: Any process that modulates the frequency, rate, or extent of the kinin cascade.

negative regulation of kinin cascade
type: Class
subclass of: regulation of kinin cascade
subclass of: negative regulation of acute inflammatory response
subclass of: GO_2000258
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of the kinin cascade.
has exact synonym: downregulation of kinin cascade
has exact synonym: down regulation of kinin cascade
has exact synonym: down-regulation of kinin cascade
has related synonym: inhibition of kinin cascade

positive regulation of kinin cascade
type: Class
subclass of: regulation of kinin cascade
subclass of: positive regulation of acute inflammatory response
subclass of: GO_2000259
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of the kinin cascade.
has related synonym: activation of kinin cascade
has related synonym: stimulation of kinin cascade
has exact synonym: upregulation of kinin cascade
has exact synonym: up regulation of kinin cascade
has exact synonym: up-regulation of kinin cascade

endothelial cell activation within high endothelial venule involved in immune response
type: Class
subclass of: endothelial cell activation involved in immune response
IAO_0000115: A change in the morphology or behavior of an endothelial cell within a high endothelial venule resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
has related synonym: endothelial cell activation within high endothelial venule during immune response

lymphocyte homeostasis
type: Class
subclass of: leukocyte homeostasis
IAO_0000115: The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus.

mucosal lymphocyte homeostasis
type: Class
subclass of: lymphocyte homeostasis
IAO_0000115: The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within the mucosal tissue of an organism is stable over time in the absence of an outside stimulus.

myeloid cell homeostasis
type: Class
subclass of: immune system process
subclass of: GO_0048872
IAO_0000115: The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.

cell activation involved in immune response
type: Class
subclass of: cell activation
subclass of: immune effector process
subclass of: part-of-parent-6955
IAO_0000115: A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
has related synonym: cell activation during immune response

endothelial cell activation involved in immune response
type: Class
subclass of: cell activation involved in immune response
subclass of: GO_0042118
subclass of: part-of-parent-6955
IAO_0000115: A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
has related synonym: endothelial cell activation during immune response

astrocyte activation involved in immune response
type: Class
subclass of: cell activation involved in immune response
subclass of: GO_0048143
subclass of: part-of-parent-6955
IAO_0000115: A change in the morphology or behavior of an astrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
has related synonym: astrocyte activation during immune response

follicular dendritic cell activation
type: Class
subclass of: cell activation
IAO_0000115: A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand.

follicular dendritic cell activation involved in immune response
type: Class
subclass of: cell activation involved in immune response
subclass of: follicular dendritic cell activation
subclass of: part-of-parent-6955
IAO_0000115: A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
has related synonym: follicular dendritic cell activation during immune response

follicular dendritic cell differentiation
type: Class
subclass of: follicular dendritic cell activation
subclass of: GO_0030154
IAO_0000115: The process in which a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell.

leukocyte activation involved in inflammatory response
type: Class
subclass of: GO_0045321
subclass of: part-of-parent-6954
IAO_0000115: A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response.
has related synonym: immune cell activation during inflammatory response
has related synonym: leukocyte activation during inflammatory response

plasmacytoid dendritic cell activation
type: Class
subclass of: GO_0045321
IAO_0000115: A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand.

plasmacytoid dendritic cell activation involved in immune response
type: Class
subclass of: plasmacytoid dendritic cell activation
subclass of: leukocyte activation involved in immune response
subclass of: part-of-parent-6955
IAO_0000115: A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
has related synonym: plasmacytoid dendritic cell activation during immune response

plasmacytoid dendritic cell differentiation involved in immune response
type: Class
subclass of: plasmacytoid dendritic cell activation involved in immune response
subclass of: plasmacytoid dendritic cell differentiation
subclass of: part-of-parent-6955
IAO_0000115: The process in which an immature plasmacytoid dendritic cell acquires the specialized features of a mature plasmacytoid dendritic cell contributing to an immune response.
has related synonym: plasmacytoid dendritic cell differentiation during immune response

plasmacytoid dendritic cell differentiation
type: Class
subclass of: plasmacytoid dendritic cell activation
subclass of: GO_0097028
IAO_0000115: The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell.

myeloid leukocyte activation
type: Class
subclass of: GO_0045321
IAO_0000115: A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand.
has exact synonym: myeloid leucocyte activation

myeloid cell activation involved in immune response
type: Class
subclass of: myeloid leukocyte activation
subclass of: leukocyte activation involved in immune response
IAO_0000115: A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
has related synonym: myeloid cell activation during immune response

basophil activation involved in immune response
type: Class
subclass of: myeloid cell activation involved in immune response
subclass of: GO_0045575
subclass of: part-of-parent-6955
IAO_0000115: A change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response.
has related synonym: basophil activation during immune response

myeloid dendritic cell activation involved in immune response
type: Class
subclass of: myeloid dendritic cell activation
subclass of: myeloid cell activation involved in immune response
subclass of: part-of-parent-6955
IAO_0000115: The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has related synonym: myeloid dendritic cell activation during immune response

eosinophil activation involved in immune response
type: Class
subclass of: myeloid cell activation involved in immune response
subclass of: GO_0043307
subclass of: part-of-parent-6955
IAO_0000115: The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has related synonym: eosinophil activation during immune response

mast cell activation involved in immune response
type: Class
subclass of: myeloid cell activation involved in immune response
subclass of: GO_0045576
subclass of: part-of-parent-6955
IAO_0000115: The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response.
has related synonym: mast cell activation during immune response

monocyte activation involved in immune response
type: Class
subclass of: myeloid cell activation involved in immune response
subclass of: GO_0042117
subclass of: part-of-parent-6955
IAO_0000115: The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has related synonym: monocyte activation during immune response

macrophage activation involved in immune response
type: Class
subclass of: myeloid cell activation involved in immune response
subclass of: GO_0042116
subclass of: part-of-parent-6955
IAO_0000115: A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has related synonym: macrophage activation during immune response
has exact synonym: macrophage polarization involved in immune response

microglial cell activation involved in immune response
type: Class
subclass of: microglial cell activation
subclass of: macrophage activation involved in immune response
subclass of: part-of-parent-6955
IAO_0000115: The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has related synonym: microglial cell activation during immune response

neutrophil activation involved in immune response
type: Class
subclass of: myeloid cell activation involved in immune response
subclass of: GO_0042119
subclass of: part-of-parent-6955
IAO_0000115: The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has related synonym: neutrophil activation during immune response

myeloid dendritic cell differentiation involved in immune response
type: Class
subclass of: myeloid dendritic cell activation involved in immune response
subclass of: GO_0043011
subclass of: part-of-parent-6955
IAO_0000115: The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response.
has related synonym: myeloid dendritic cell differentiation during immune response

lymphocyte activation involved in immune response
type: Class
subclass of: leukocyte activation involved in immune response
subclass of: GO_0046649
subclass of: part-of-parent-6955
IAO_0000115: A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has related synonym: lymphocyte activation during immune response

T cell activation involved in immune response
type: Class
subclass of: lymphocyte activation involved in immune response
subclass of: GO_0042110
subclass of: part-of-parent-6955
IAO_0000115: The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.
has related synonym: T cell activation during immune response
has related synonym: T-cell activation during immune response
has related synonym: T lymphocyte activation during immune response
has related synonym: T-lymphocyte activation during immune response

alpha-beta T cell activation involved in immune response
type: Class
subclass of: T cell activation involved in immune response
subclass of: GO_0046631
subclass of: part-of-parent-6955
IAO_0000115: The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.
has related synonym: alpha-beta T cell activation during immune response
has related synonym: alpha-beta T-cell activation during immune response
has related synonym: alpha-beta T lymphocyte activation during immune response
has related synonym: alpha-beta T-lymphocyte activation during immune response

NK T cell activation involved in immune response
type: Class
subclass of: alpha-beta T cell activation involved in immune response
subclass of: GO_0051132
subclass of: part-of-parent-6955
IAO_0000115: The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.
has related synonym: natural killer T-cell activation during immune response
has related synonym: natural killer T lymphocyte activation during immune response
has related synonym: natural killer T-lymphocyte activation during immune response
has related synonym: NK T cell activation during immune response
has related synonym: NK T-cell activation during immune response
has related synonym: NK T lymphocyte activation during immune response
has related synonym: NK T-lymphocyte activation during immune response

NK T cell proliferation involved in immune response
type: Class
subclass of: NK T cell proliferation
subclass of: NK T cell activation involved in immune response
subclass of: alpha-beta T cell proliferation involved in immune response
subclass of: part-of-parent-6955
IAO_0000115: The expansion of a NK T cell population by cell division as part of an immune response.
has related synonym: natural killer T-cell proliferation during immune response
has related synonym: natural killer T lymphocyte proliferation during immune response
has related synonym: natural killer T-lymphocyte proliferation during immune response
has related synonym: NK T cell proliferation during immune response
has related synonym: NK T-cell proliferation during immune response
has related synonym: NK T lymphocyte proliferation during immune response
has related synonym: NK T-lymphocyte proliferation during immune response

gamma-delta T cell activation involved in immune response
type: Class
subclass of: T cell activation involved in immune response
subclass of: GO_0046629
subclass of: part-of-parent-6955
IAO_0000115: The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.
has related synonym: gamma-delta T cell activation during immune response
has related synonym: gamma-delta T-cell activation during immune response
has related synonym: gamma-delta T lymphocyte activation during immune response
has related synonym: gamma-delta T-lymphocyte activation during immune response

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
type: Class
subclass of: T cell activation involved in immune response
IAO_0000115: The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response.
has exact synonym: T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
has exact synonym: T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
has exact synonym: T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

T cell differentiation involved in immune response
type: Class
subclass of: T cell activation involved in immune response
subclass of: GO_0030217
subclass of: part-of-parent-6955
IAO_0000115: The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.
has related synonym: T cell development involved in immune response
has related synonym: T cell differentiation during immune response
has related synonym: T-cell differentiation during immune response
has related synonym: T lymphocyte differentiation during immune response
has related synonym: T-lymphocyte differentiation during immune response

alpha-beta T cell differentiation involved in immune response
type: Class
subclass of: alpha-beta T cell activation involved in immune response
subclass of: T cell differentiation involved in immune response
subclass of: GO_0046632
subclass of: part-of-parent-6955
IAO_0000115: The process in which an antigenically naive alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.
has related synonym: alpha-beta T cell development involved in immune response
has related synonym: alpha-beta T cell differentiation during immune response
has related synonym: alpha-beta T-cell differentiation during immune response
has related synonym: alpha-beta T lymphocyte differentiation during immune response
has related synonym: alpha-beta T-lymphocyte differentiation during immune response

CD4-positive, alpha-beta T cell differentiation involved in immune response
type: Class
subclass of: alpha-beta T cell differentiation involved in immune response
subclass of: GO_0043367
subclass of: part-of-parent-6955
IAO_0000115: The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.
has related synonym: CD4-positive, alpha-beta T cell development involved in immune response
has related synonym: CD4-positive, alpha-beta T cell differentiation during immune response
has related synonym: CD4-positive, alpha-beta T-cell differentiation during immune response
has related synonym: CD4-positive, alpha-beta T lymphocyte differentiation during immune response
has related synonym: CD4-positive, alpha-beta T-lymphocyte differentiation during immune response

T-helper cell lineage commitment
type: Class
subclass of: GO_0043373
subclass of: part-of-parent-42093
IAO_0000115: The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper cell, a CD4-positive, alpha-beta T cell specialized to promote various immunological processes.
has related synonym: Th0 lineage commitment
has exact synonym: T-helper cell fate commitment
has related synonym: Thp lineage commitment

T-helper 1 cell lineage commitment
type: Class
subclass of: T-helper cell lineage commitment
subclass of: part-of-parent-45063
IAO_0000115: The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 1 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis.
has exact synonym: Th1 cell lineage commitment
has exact synonym: Th1 fate commitment
has exact synonym: T-helper 1 cell fate commitment

T-helper 2 cell lineage commitment
type: Class
subclass of: T-helper cell lineage commitment
subclass of: part-of-parent-45064
IAO_0000115: The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 2 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to extracellular organisms such as helminths, enhanced production of particular antibody isotypes, and pathological conditions such as allergy.
has exact synonym: Th2 fate commitment
has exact synonym: T-helper 2 cell fate commitment

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
type: Class
subclass of: CD4-positive, alpha-beta T cell differentiation involved in immune response
subclass of: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
subclass of: part-of-parent-6955
IAO_0000115: The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell as part of an immune response.
has related synonym: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response
has related synonym: CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response
has related synonym: CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response
has related synonym: CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response
has related synonym: CD4-positive, CD25-positive, alpha-beta T cell development involved in immune response

alpha-beta intraepithelial T cell differentiation
type: Class
subclass of: GO_0046632
IAO_0000115: The process in which a precursor cell type acquires the specialized features of an alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
has related synonym: alpha-beta intraepithelial T cell development
has exact synonym: alpha-beta intraepithelial T-cell differentiation
has exact synonym: alpha-beta intraepithelial T lymphocyte differentiation
has exact synonym: alpha-beta intraepithelial T-lymphocyte differentiation

CD8-positive, alpha-beta intraepithelial T cell differentiation
type: Class
subclass of: alpha-beta intraepithelial T cell differentiation
subclass of: GO_0043374
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
has related synonym: CD8-positive, alpha-beta intraepithelial T cell development
has exact synonym: CD8-positive, alpha-beta intraepithelial T-cell differentiation
has exact synonym: CD8-positive, alpha-beta intraepithelial T lymphocyte differentiation
has exact synonym: CD8-positive, alpha-beta intraepithelial T-lymphocyte differentiation

CD4-positive, alpha-beta intraepithelial T cell differentiation
type: Class
subclass of: alpha-beta intraepithelial T cell differentiation
subclass of: GO_0043367
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a CD4-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
has related synonym: CD4-positive, alpha-beta intraepithelial T cell development
has exact synonym: CD4-positive, alpha-beta intraepithelial T-cell differentiation
has exact synonym: CD4-positive, alpha-beta intraepithelial T lymphocyte differentiation
has exact synonym: CD4-positive, alpha-beta intraepithelial T-lymphocyte differentiation

CD8-positive, alpha-beta T cell differentiation involved in immune response
type: Class
subclass of: alpha-beta T cell differentiation involved in immune response
subclass of: GO_0043374
subclass of: part-of-parent-6955
IAO_0000115: The process in which an antigenically naive CD8-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.
has related synonym: CD8-positive, alpha-beta intraepithelial T cell development
has related synonym: CD8-positive, alpha-beta T cell differentiation during immune response
has related synonym: CD8-positive, alpha-beta T-cell differentiation during immune response
has related synonym: CD8-positive, alpha-beta T lymphocyte differentiation during immune response
has related synonym: CD8-positive, alpha-beta T-lymphocyte differentiation during immune response

gamma-delta T cell differentiation involved in immune response
type: Class
subclass of: gamma-delta T cell activation involved in immune response
subclass of: T cell differentiation involved in immune response
subclass of: GO_0042492
subclass of: part-of-parent-6955
IAO_0000115: The process in which an antigenically naive gamma-delta T cell acquires the specialized features of an effector, regulatory, or memory T cell and contributes to an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.
has related synonym: gamma-delta T cell development involved in immune response
has related synonym: gamma-delta T cell differentiation during immune response
has related synonym: gamma-delta T-cell differentiation during immune response
has related synonym: gamma-delta T lymphocyte differentiation during immune response
has related synonym: gamma-delta T-lymphocyte differentiation during immune response

gamma-delta intraepithelial T cell differentiation
type: Class
subclass of: GO_0042492
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
has related synonym: gamma-delta intraepithelial T cell development
has exact synonym: gamma-delta intraepithelial T-cell differentiation
has exact synonym: gamma-delta intraepithelial T lymphocyte differentiation
has exact synonym: gamma-delta intraepithelial T-lymphocyte differentiation

CD8-positive, gamma-delta intraepithelial T cell differentiation
type: Class
subclass of: gamma-delta intraepithelial T cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a CD8-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
has related synonym: CD8-positive, gamma-delta intraepithelial T cell development
has exact synonym: CD8-positive, gamma-delta intraepithelial T-cell differentiation
has exact synonym: CD8-positive, gamma-delta intraepithelial T lymphocyte differentiation
has exact synonym: CD8-positive, gamma-delta intraepithelial T-lymphocyte differentiation

CD4-positive gamma-delta intraepithelial T cell differentiation
type: Class
subclass of: gamma-delta intraepithelial T cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a CD4-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
has related synonym: CD4-positive, gamma-delta intraepithelial T cell development
has exact synonym: CD4-positive, gamma-delta intraepithelial T-cell differentiation
has exact synonym: CD4-positive, gamma-delta intraepithelial T lymphocyte differentiation
has exact synonym: CD4-positive, gamma-delta intraepithelial T-lymphocyte differentiation

CD8-positive, alpha-beta regulatory T cell differentiation
type: Class
subclass of: GO_0043374
subclass of: GO_0045066
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta regulatory T cell.
has related synonym: CD8-positive, alpha-beta regulatory T cell development
has exact synonym: CD8-positive, alpha-beta regulatory T-cell differentiation
has exact synonym: CD8-positive, alpha-beta regulatory T lymphocyte differentiation
has exact synonym: CD8-positive, alpha-beta regulatory T-lymphocyte differentiation

CD8-positive, alpha-beta cytotoxic T cell differentiation
type: Class
subclass of: GO_0043374
subclass of: GO_0045065
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta cytotoxic T cell.
has related synonym: CD8-positive, alpha-beta cytotoxic T cell development
has exact synonym: CD8-positive, alpha-beta cytotoxic T-cell differentiation
has exact synonym: CD8-positive, alpha-beta cytotoxic T lymphocyte differentiation
has exact synonym: CD8-positive, alpha-beta cytotoxic T-lymphocyte differentiation

T cell proliferation involved in immune response
type: Class
subclass of: T cell activation involved in immune response
subclass of: GO_0042098
subclass of: part-of-parent-6955
IAO_0000115: The expansion of a T cell population by cell division as part of an immune response.
has related synonym: T cell proliferation during immune response
has related synonym: T-cell proliferation during immune response
has related synonym: T lymphocyte proliferation during immune response
has related synonym: T-lymphocyte proliferation during immune response

alpha-beta T cell proliferation involved in immune response
type: Class
subclass of: alpha-beta T cell activation involved in immune response
subclass of: T cell proliferation involved in immune response
subclass of: GO_0046633
subclass of: part-of-parent-6955
IAO_0000115: The expansion of an alpha-beta T cell population by cell division as part of an immune response.
has related synonym: alpha-beta T cell proliferation during immune response
has related synonym: alpha-beta T-cell proliferation during immune response
has related synonym: alpha-beta T lymphocyte proliferation during immune response
has related synonym: alpha-beta T-lymphocyte proliferation during immune response

gamma-delta T cell proliferation involved in immune response
type: Class
subclass of: gamma-delta T cell activation involved in immune response
subclass of: T cell proliferation involved in immune response
subclass of: GO_0046630
subclass of: part-of-parent-6955
IAO_0000115: The expansion of a gamma-delta T cell population by cell division as part of an immune response.
has related synonym: gamma-delta T cell proliferation during immune response
has related synonym: gamma-delta T-cell proliferation during immune response
has related synonym: gamma-delta T lymphocyte proliferation during immune response
has related synonym: gamma-delta T-lymphocyte proliferation during immune response

B cell activation involved in immune response
type: Class
subclass of: lymphocyte activation involved in immune response
subclass of: GO_0042113
subclass of: part-of-parent-6955
IAO_0000115: The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
has related synonym: B cell activation during immune response
has related synonym: B-cell activation during immune response
has related synonym: B lymphocyte activation during immune response
has related synonym: B-lymphocyte activation during immune response

mature B cell differentiation involved in immune response
type: Class
subclass of: B cell activation involved in immune response
subclass of: mature B cell differentiation
subclass of: part-of-parent-6955
IAO_0000115: The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response.
has related synonym: mature B cell development involved in immune response
has related synonym: mature B cell differentiation during immune response
has related synonym: mature B-cell differentiation during immune response
has related synonym: mature B lymphocyte differentiation during immune response
has related synonym: mature B-lymphocyte differentiation during immune response

germinal center B cell differentiation
type: Class
subclass of: mature B cell differentiation involved in immune response
IAO_0000115: The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA).
has related synonym: germinal center B cell development
has exact synonym: germinal center B-cell differentiation
has exact synonym: germinal center B lymphocyte differentiation
has exact synonym: germinal center B-lymphocyte differentiation

marginal zone B cell differentiation
type: Class
subclass of: mature B cell differentiation involved in immune response
IAO_0000115: The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL).
has related synonym: marginal zone B cell development
has exact synonym: marginal zone B-cell differentiation
has exact synonym: marginal zone B lymphocyte differentiation
has exact synonym: marginal zone B-lymphocyte differentiation

follicular B cell differentiation
type: Class
subclass of: mature B cell differentiation involved in immune response
IAO_0000115: The process in which a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region.
has related synonym: follicular B cell development
has exact synonym: follicular B-cell differentiation
has exact synonym: follicular B lymphocyte differentiation
has exact synonym: follicular B-lymphocyte differentiation

plasma cell differentiation
type: Class
subclass of: mature B cell differentiation involved in immune response
IAO_0000115: The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody.
has related synonym: plasma cell development

myeloid progenitor cell differentiation
type: Class
subclass of: hematopoietic progenitor cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages.

memory B cell differentiation
type: Class
subclass of: mature B cell differentiation involved in immune response
subclass of: GO_0090715
IAO_0000115: The process in which a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody.
has related synonym: memory B cell development
has exact synonym: memory B-cell differentiation
has exact synonym: memory B lymphocyte differentiation
has exact synonym: memory B-lymphocyte differentiation

lymphoid progenitor cell differentiation
type: Class
subclass of: hematopoietic progenitor cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages.

natural killer cell progenitor differentiation
type: Class
subclass of: lymphoid progenitor cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a natural killer cell progenitor.

B cell proliferation involved in immune response
type: Class
subclass of: B cell activation involved in immune response
subclass of: GO_0042100
subclass of: part-of-parent-6955
IAO_0000115: The expansion of a B cell population by cell division following B cell activation during an immune response.
has related synonym: B cell proliferation during immune response
has related synonym: B-cell proliferation during immune response
has related synonym: B lymphocyte proliferation during immune response
has related synonym: B-lymphocyte proliferation during immune response

natural killer cell activation involved in immune response
type: Class
subclass of: lymphocyte activation involved in immune response
subclass of: GO_0030101
subclass of: part-of-parent-6955
IAO_0000115: The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has related synonym: natural killer cell activation during immune response
has related synonym: NK cell activation during immune response

natural killer cell proliferation involved in immune response
type: Class
subclass of: natural killer cell proliferation
subclass of: natural killer cell activation involved in immune response
subclass of: part-of-parent-6955
IAO_0000115: The expansion of a natural killer cell population by cell division as part of an immune response.
has related synonym: natural killer cell proliferation during immune response
has related synonym: NK cell proliferation during immune response

natural killer cell differentiation involved in immune response
type: Class
subclass of: natural killer cell differentiation
subclass of: natural killer cell activation involved in immune response
subclass of: part-of-parent-6955
IAO_0000115: The process in which a naive natural killer cell acquires the specialized features of an effector natural killer T cell as part of an immune response.
has related synonym: natural killer cell development involved in immune response
has related synonym: natural killer cell differentiation during immune response
has related synonym: NK cell differentiation during immune response

B cell lineage commitment
type: Class
subclass of: GO_0045165
subclass of: part-of-parent-30183
IAO_0000115: The process in which a lymphoid progenitor cell becomes committed to become any type of B cell.
has exact synonym: B-cell lineage commitment
has exact synonym: B lymphocyte lineage commitment
has exact synonym: B-lymphocyte lineage commitment

immature B cell differentiation
type: Class
subclass of: GO_0030183
IAO_0000115: The process in which a precursor cell type acquires the specialized features of an immature B cell.
has related synonym: immature B cell development
has exact synonym: immature B-cell differentiation
has exact synonym: immature B lymphocyte differentiation
has exact synonym: immature B-lymphocyte differentiation

pro-B cell differentiation
type: Class
subclass of: lymphoid progenitor cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed.
has related synonym: pro-B cell development
has exact synonym: pro-B lymphocyte differentiation

pre-B cell differentiation
type: Class
subclass of: immature B cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments.
has related synonym: pre-B cell development
has exact synonym: pre-B lymphocyte differentiation

pre-B cell receptor expression
type: Class
subclass of: GO_0048869
subclass of: part-of-parent-2329
IAO_0000115: The process leading up to expression of the pre-B cell receptor on the surface of pre-B cells, starting with the recombination of an immunuglobulin heavy chain locus, including expression of the surrogate light chain, the association of the surrogate light chain with the heavy chain, and expression of the complete pre-B cell receptor on the cell surface. pre-B cell receptor expression is a key checkpoint in the transition of pro-B cell to pre-B cell.

pre-B cell allelic exclusion
type: Class
subclass of: GO_0010468
subclass of: part-of-parent-2329
IAO_0000115: Expression of a single heavy chain allele during pre-B cell differentiation.
has exact synonym: pre-B lymphocyte allelic exclusion

transitional stage B cell differentiation
type: Class
subclass of: immature B cell differentiation
IAO_0000115: The process in which immature B cells from the bone marrow become mature B cells in the spleen. Transitional stage B cells are subdivided into transitional one (T1) and transitional two (T2) stages and are short-lived and functionally incompetent.
has related synonym: transitional stage B cell development
has exact synonym: transitional stage B-cell differentiation
has exact synonym: transitional stage B lymphocyte differentiation
has exact synonym: transitional stage B-lymphocyte differentiation

transitional one stage B cell differentiation
type: Class
subclass of: transitional stage B cell differentiation
IAO_0000115: The process in which immature B cells from the bone marrow acquire the specialized features of T1 stage B cells in the spleen. T1 stage B cells do not express either CD23 or CD21.
has exact synonym: T1 stage B cell differentiation
has related synonym: transitional one stage B cell development
has exact synonym: transitional one stage B-cell differentiation
has exact synonym: transitional one stage B lymphocyte differentiation
has exact synonym: transitional one stage B-lymphocyte differentiation

transitional two stage B cell differentiation
type: Class
subclass of: transitional stage B cell differentiation
IAO_0000115: The process in which immature B cells from the bone marrow acquire the specialized features of T2 stage B cells in the spleen. T2 stage B cells express CD23 but not CD21.
has exact synonym: T2 stage B cell differentiation
has related synonym: transitional two stage B cell development
has exact synonym: transitional two stage B-cell differentiation
has exact synonym: transitional two stage B lymphocyte differentiation
has exact synonym: transitional two stage B-lymphocyte differentiation

mature B cell differentiation
type: Class
subclass of: GO_0030183
IAO_0000115: The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen.
has exact synonym: mature B-cell differentiation
has exact synonym: mature B lymphocyte differentiation
has exact synonym: mature B-lymphocyte differentiation
has related synonym: mature cell development

B-1 B cell lineage commitment
type: Class
subclass of: B cell lineage commitment
subclass of: part-of-parent-1923
IAO_0000115: The process in which an immature B cell becomes committed to become a B-1 B cell.
has exact synonym: B-1 B-cell lineage commitment
has exact synonym: B-1 B lymphocyte lineage commitment
has exact synonym: B-1 B-lymphocyte lineage commitment

B-1a B cell differentiation
type: Class
subclass of: B-1 B cell differentiation
IAO_0000115: The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors.
has related synonym: B-1a B cell development
has exact synonym: B-1a B-cell differentiation
has exact synonym: B-1a B lymphocyte differentiation
has exact synonym: B-1a B-lymphocyte differentiation

B-1b B cell differentiation
type: Class
subclass of: B-1 B cell differentiation
IAO_0000115: The process in which B cells acquire the specialized features of B-1b B cells. B-1b B cells are B-1 cells that do not express CD5.
has related synonym: B-1b B cell development
has exact synonym: B-1b B-cell differentiation
has exact synonym: B-1b B lymphocyte differentiation
has exact synonym: B-1b B-lymphocyte differentiation

B cell selection
type: Class
subclass of: immune system process
subclass of: part-of-parent-30183
IAO_0000115: The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival.
has exact synonym: B-cell selection
has exact synonym: B lymphocyte selection
has exact synonym: B-lymphocyte selection

central B cell selection
type: Class
subclass of: B cell selection
IAO_0000115: Any B cell selection process that occurs in the bone marrow.
has exact synonym: central B-cell selection
has exact synonym: central B lymphocyte selection
has exact synonym: central B-lymphocyte selection

central B cell anergy
type: Class
subclass of: B cell anergy
subclass of: part-of-parent-2340
subclass of: part-of-parent-2510
IAO_0000115: Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in B cells in the bone marrow.
has exact synonym: central B-cell anergy
has exact synonym: central B lymphocyte anergy
has exact synonym: central B-lymphocyte anergy

central B cell deletion
type: Class
subclass of: B cell deletion
subclass of: part-of-parent-2340
subclass of: part-of-parent-2510
IAO_0000115: The deletion of B cells by apoptotic process occurring as part of central tolerance induction and B cell selection.
has exact synonym: central B-cell deletion
has exact synonym: central B lymphocyte deletion
has exact synonym: central B-lymphocyte deletion

peripheral B cell selection
type: Class
subclass of: B cell selection
IAO_0000115: Any B cell selection process that occurs in the periphery.
has exact synonym: peripheral B-cell selection
has exact synonym: peripheral B lymphocyte selection
has exact synonym: peripheral B-lymphocyte selection

B cell affinity maturation
type: Class
subclass of: peripheral B cell selection
subclass of: part-of-parent-2381
IAO_0000115: The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen.
has exact synonym: B-cell affinity maturation
has exact synonym: B lymphocyte affinity maturation
has exact synonym: B-lymphocyte affinity maturation

peripheral B cell receptor editing
type: Class
subclass of: B cell receptor editing
IAO_0000115: The process that takes place mainly in germinal center B cells in which a large number of mutations are generated in the heavy chain and light chain V-region genes and their immediately surrounding introns in order to increase antibody diversity and contribute to affinity maturation.
has exact synonym: peripheral B-cell receptor editing
has exact synonym: peripheral B lymphocyte receptor editing
has exact synonym: peripheral B-lymphocyte receptor editing

B cell positive selection
type: Class
subclass of: B cell selection
IAO_0000115: Any process in which B cells are selected to survive based on signaling through the B cell antigen receptor.
has exact synonym: B-cell positive selection
has exact synonym: B lymphocyte positive selection
has exact synonym: B-lymphocyte positive selection

response to tumor cell
type: Class
subclass of: GO_0009607
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell.

central B cell positive selection
type: Class
subclass of: central B cell selection
subclass of: B cell positive selection
IAO_0000115: Any process leading to positive selection of B cells in the bone marrow. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors.
has exact synonym: central B-cell positive selection
has exact synonym: central B lymphocyte positive selection
has exact synonym: central B-lymphocyte positive selection

histamine production involved in inflammatory response
type: Class
subclass of: production of molecular mediator involved in inflammatory response
IAO_0000115: The synthesis or release of histamine following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
has related synonym: histamine production involved in acute inflammatory response

peripheral B cell positive selection
type: Class
subclass of: peripheral B cell selection
subclass of: B cell positive selection
IAO_0000115: Any process leading to positive selection of B cells in the periphery. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors.
has exact synonym: peripheral B-cell positive selection
has exact synonym: peripheral B lymphocyte positive selection
has exact synonym: peripheral B-lymphocyte positive selection

serotonin production involved in inflammatory response
type: Class
subclass of: production of molecular mediator involved in inflammatory response
IAO_0000115: The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
has related synonym: serotonin production involved in acute inflammatory response

B cell negative selection
type: Class
subclass of: B cell selection
IAO_0000115: Any process leading to negative selection in B cells. Mechanisms of negative selection include anergy and deletion.
has exact synonym: B-cell negative selection
has exact synonym: B lymphocyte negative selection
has exact synonym: B-lymphocyte negative selection

plasma kallikrein-kinin cascade
type: Class
subclass of: kinin cascade
IAO_0000115: A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininogen. The ultimate product of the plasma kallikrein-kinin cascade is bradykinin, an agent known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability.

central B cell negative selection
type: Class
subclass of: central B cell selection
subclass of: B cell negative selection
IAO_0000115: Any process leading to negative selection of B cells in the bone marrow.
has exact synonym: central B-cell negative selection
has exact synonym: central B lymphocyte negative selection
has exact synonym: central B-lymphocyte negative selection

detection of tumor cell
type: Class
subclass of: response to tumor cell
subclass of: GO_0009595
IAO_0000115: The series of events in which a stimulus from a tumor cell is received and converted into a molecular signal.

peripheral B cell negative selection
type: Class
subclass of: peripheral B cell selection
subclass of: B cell negative selection
IAO_0000115: Any process leading to negative selection of B cells in the periphery.
has exact synonym: peripheral B-cell negative selection
has exact synonym: peripheral B lymphocyte negative selection
has exact synonym: peripheral B-lymphocyte negative selection

defense response to tumor cell
type: Class
subclass of: response to tumor cell
subclass of: GO_0006952
IAO_0000115: Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism.

B cell homeostatic proliferation
type: Class
subclass of: GO_0042100
subclass of: part-of-parent-42592
IAO_0000115: The non-specific expansion of B cell populations within a whole or part of an organism to reach to a total number of B cells which will then remain stable over time in the absence of an external stimulus.
has exact synonym: B-cell homeostatic proliferation
has exact synonym: B lymphocyte homeostatic proliferation
has exact synonym: B-lymphocyte homeostatic proliferation

B-1 B cell proliferation
type: Class
subclass of: GO_0042100
IAO_0000115: The expansion of a B-1 B cell by cell division. Follows B cell activation.
has exact synonym: B-1 B-cell proliferation
has exact synonym: B-1 B lymphocyte proliferation
has exact synonym: B-1 B-lymphocyte proliferation

T cell lineage commitment
type: Class
subclass of: GO_0045165
subclass of: part-of-parent-30217
IAO_0000115: The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell.
has exact synonym: T-cell lineage commitment
has exact synonym: T lymphocyte lineage commitment
has exact synonym: T-lymphocyte lineage commitment

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
type: Class
subclass of: GO_0043367
subclass of: GO_0045066
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell.
has related synonym: CD4-positive, CD25-positive, alpha-beta regulatory T cell development
has exact synonym: CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation
has exact synonym: CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation
has exact synonym: CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation

CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
type: Class
subclass of: GO_0043373
subclass of: part-of-parent-2361
IAO_0000115: The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a CD4-positive, CD25-positive, alpha-beta regulatory T cell.
has exact synonym: CD4-positive, CD25-positive, alpha-beta regulatory T-cell lineage commitment
has exact synonym: CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte lineage commitment
has exact synonym: CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte lineage commitment

alpha-beta T cell lineage commitment
type: Class
subclass of: T cell lineage commitment
subclass of: part-of-parent-46632
IAO_0000115: The process in which a pro-T cell becomes committed to becoming an alpha-beta T cell.
has exact synonym: alpha-beta T-cell lineage commitment
has exact synonym: alpha-beta T lymphocyte lineage commitment
has exact synonym: alpha-beta T-lymphocyte lineage commitment

NK T cell lineage commitment
type: Class
subclass of: alpha-beta T cell lineage commitment
subclass of: part-of-parent-1865
IAO_0000115: The process in which a pro-T cell becomes committed to becoming an NK T cell.
has exact synonym: natural killer T-cell lineage commitment
has exact synonym: natural killer T lymphocyte lineage commitment
has exact synonym: natural killer T-lymphocyte lineage commitment
has exact synonym: NK T-cell lineage commitment
has exact synonym: NK T lymphocyte lineage commitment
has exact synonym: NK T-lymphocyte lineage commitment

gamma-delta T cell lineage commitment
type: Class
subclass of: T cell lineage commitment
subclass of: part-of-parent-42492
IAO_0000115: The process in which a pro-T cell becomes committed to becoming a gamma-delta T cell.
has exact synonym: gamma-delta T-cell lineage commitment
has exact synonym: gamma-delta T lymphocyte lineage commitment
has exact synonym: gamma-delta T-lymphocyte lineage commitment

leukocyte activation involved in immune response
type: Class
subclass of: cell activation involved in immune response
subclass of: GO_0045321
subclass of: part-of-parent-6955
IAO_0000115: A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has related synonym: immune cell activation during immune response
has related synonym: leucocyte activation during immune response
has related synonym: leukocyte activation during immune response

cytokine production involved in immune response
type: Class
subclass of: cytokine production
subclass of: production of molecular mediator of immune response
subclass of: part-of-parent-6955
IAO_0000115: The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels.
has related synonym: cytokine biosynthetic process involved in immune response
has related synonym: cytokine production during immune response
has related synonym: cytokine secretion during immune response
has related synonym: cytokine secretion involved in immune response
replaces: GO_0002374
replaces: GO_0002375

B cell cytokine production
type: Class
subclass of: cytokine production involved in immune response
subclass of: GO_0019724
IAO_0000115: Any process that contributes to cytokine production by a B cell.
has exact synonym: B-cell cytokine production
has exact synonym: B lymphocyte cytokine production
has exact synonym: B-lymphocyte cytokine production

T cell cytokine production
type: Class
subclass of: cytokine production involved in immune response
subclass of: T cell mediated immunity
IAO_0000115: Any process that contributes to cytokine production by a T cell.
has exact synonym: T-cell cytokine production
has exact synonym: T lymphocyte cytokine production
has exact synonym: T-lymphocyte cytokine production

natural killer cell cytokine production
type: Class
subclass of: natural killer cell mediated immunity
subclass of: cytokine production involved in immune response
IAO_0000115: Any process that contributes to cytokine production by a natural killer cell.
has exact synonym: NK cell cytokine production

dendritic cell cytokine production
type: Class
subclass of: cytokine production involved in immune response
subclass of: leukocyte mediated immunity
IAO_0000115: Any process that contributes to cytokine production by a dendritic cell.

myeloid dendritic cell cytokine production
type: Class
subclass of: dendritic cell cytokine production
subclass of: myeloid leukocyte mediated immunity
subclass of: GO_0061082
IAO_0000115: Any process that contributes to cytokine production by a myeloid dendritic cell.

plasmacytoid dendritic cell cytokine production
type: Class
subclass of: dendritic cell cytokine production
IAO_0000115: Any process that contributes to cytokine production by a plasmacytoid dendritic cell.

immune system process
type: Class
subclass of: GO_0008150
IAO_0000115: Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

immunoglobulin production
type: Class
subclass of: production of molecular mediator of immune response
IAO_0000115: The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has exact synonym: antibody production
has related synonym: immunoglobulin biosynthetic process
has related synonym: immunoglobulin secretion
replaces: GO_0002378
replaces: GO_0048305

immunoglobulin production involved in immunoglobulin-mediated immune response
type: Class
subclass of: immunoglobulin production
subclass of: part-of-parent-16064
IAO_0000115: The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels.
has related synonym: antibody production during immune response
has related synonym: antibody secretion during immune response
has related synonym: immunoglobulin biosynthetic process involved in immune response
has related synonym: immunoglobulin production during immune response
has related synonym: immunoglobulin production involved in immune response
has exact synonym: immunoglobulin production involved in immunoglobulin mediated immune response
has related synonym: immunoglobulin secretion involved in immune response
replaces: GO_0002379
replaces: GO_0002380

regulation of tissue kallikrein-kinin cascade
type: Class
subclass of: regulation of kinin cascade
IAO_0000115: Any process that modulates the frequency, rate, or extent of the tissue kallikrein-kinin cascade.
has exact synonym: regulation of glandular kallikrein-kinin cascade

immune response in brain or nervous system
type: Class
subclass of: organ or tissue specific immune response
IAO_0000115: An immune response taking place in the brain or nervous system.

hepatic immune response
type: Class
subclass of: organ or tissue specific immune response
IAO_0000115: An immune response taking place in the liver.

mucosal immune response
type: Class
subclass of: organ or tissue specific immune response
IAO_0000115: An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract.
has related synonym: immune response in MALT
has related synonym: immune response in mucosal-associated lymphoid tissue
has related synonym: immune response in urogenital tract
replaces: GO_0002386
replaces: GO_0002422

immune response in gut-associated lymphoid tissue
type: Class
subclass of: GO_0006955
IAO_0000115: Immune response taking place in the gut-associated lymphoid tissue (GALT). GALT includes Peyer's patches, appendix, and solitary lymph nodules.
has exact synonym: immune response in GALT

immune response in Peyer's patch
type: Class
subclass of: immune response in gut-associated lymphoid tissue
IAO_0000115: Immune response taking place in the Peyer's patch, nodular lymphoid structures on the serosal surface of the small intestine.

tolerance induction in Peyer's patch
type: Class
subclass of: immune response in Peyer's patch
subclass of: tolerance induction in gut-associated lymphoid tissue
IAO_0000115: Tolerance induction taking place in the Peyer's patches.

platelet activating factor production involved in inflammatory response
type: Class
subclass of: production of molecular mediator involved in inflammatory response
IAO_0000115: The synthesis or release of platelet activating factor following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
has related synonym: platelet activating factor production
has related synonym: platelet activating factor production involved in acute inflammatory response
has related synonym: platelet activating factor secretion
has related synonym: platelet activating factor secretion involved in acute inflammatory response
has related synonym: platelet activating factor secretion involved in inflammatory response
replaces: GO_0002390
replaces: GO_0002392
replaces: GO_0002535

lysosomal enzyme production involved in inflammatory response
type: Class
subclass of: production of molecular mediator involved in inflammatory response
IAO_0000115: The synthesis or release of lysosomal enzymes following a stimulus as part of a inflammatory response, resulting in an increase in intracellular or extracellular levels.
has related synonym: lysosomal enzyme production involved in acute inflammatory response
has related synonym: production of lysosomal enzymes involved in acute inflammatory response
has exact synonym: production of lysosomal enzymes involved in inflammatory response

tolerance induction in gut-associated lymphoid tissue
type: Class
subclass of: immune response in gut-associated lymphoid tissue
subclass of: tolerance induction in mucosal-associated lymphoid tissue
IAO_0000115: Tolerance induction taking place in the gut-associated lymphoid tissue (GALT).
has related synonym: oral tolerance
has exact synonym: tolerance induction in GALT

immune response in nasopharyngeal-associated lymphoid tissue
type: Class
subclass of: immune response in gut-associated lymphoid tissue
IAO_0000115: An immune response taking place in the nasopharyngeal-associated lymphoid tissue (NALT). NALT includes the tonsils and adenoids.
has exact synonym: immune response in NALT

MHC protein complex assembly
type: Class
subclass of: GO_0065003
IAO_0000115: The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex.

MHC class I protein complex assembly
type: Class
subclass of: MHC protein complex assembly
IAO_0000115: The aggregation, arrangement and bonding together of a set of components to form an MHC class I protein complex. Class I here refers to classical class I molecules.

MHC class Ib protein complex assembly
type: Class
subclass of: MHC protein complex assembly
IAO_0000115: The aggregation, arrangement and bonding together of a set of components to form an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules.

MHC class II protein complex assembly
type: Class
subclass of: MHC protein complex assembly
IAO_0000115: The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex.

tolerance induction in nasopharyngeal-associated lymphoid tissue
type: Class
subclass of: tolerance induction in gut-associated lymphoid tissue
subclass of: immune response in nasopharyngeal-associated lymphoid tissue
IAO_0000115: Tolerance induction taking place in the nasopharyngeal-associated lymphoid tissue (NALT).
has related synonym: nasal tolerance
has exact synonym: tolerance induction in NALT

tolerance induction in mucosal-associated lymphoid tissue
type: Class
subclass of: mucosal tolerance induction
IAO_0000115: Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT).
has exact synonym: tolerance induction in MALT

B cell tolerance induction in mucosal-associated lymphoid tissue
type: Class
subclass of: tolerance induction in mucosal-associated lymphoid tissue
subclass of: peripheral B cell tolerance induction
IAO_0000115: Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by B cells.
has exact synonym: B cell tolerance induction in MALT

T cell tolerance induction in mucosal-associated lymphoid tissue
type: Class
subclass of: tolerance induction in mucosal-associated lymphoid tissue
subclass of: peripheral T cell tolerance induction
IAO_0000115: Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by T cells.
has exact synonym: T cell tolerance induction in MALT

antigen sampling in mucosal-associated lymphoid tissue
type: Class
subclass of: immune system process
subclass of: part-of-parent-2385
IAO_0000115: The process of apical-to-basolateral delivery of soluble and particulate antigens to underlying mucosal-associated lymphoid tissue.
has exact synonym: antigen sampling in MALT
has related synonym: antigen transport in MALT
has related synonym: antigen transport in mucosal-associated lymphoid tissue

antigen sampling by dendritic cells in mucosal-associated lymphoid tissue
type: Class
subclass of: antigen sampling in mucosal-associated lymphoid tissue
subclass of: part-of-parent-2468
IAO_0000115: The process of antigen sampling carried out by dendritic cells in the mucosal-associated lymphoid tissue.
has exact synonym: antigen sampling by dendritic cells in MALT

antigen sampling by M cells in mucosal-associated lymphoid tissue
type: Class
subclass of: antigen sampling in mucosal-associated lymphoid tissue
IAO_0000115: The process of antigen samples carried out by M cells in the mucosal-associated lymphoid tissue.
has exact synonym: antigen sampling by M cells in MALT

dendritic cell chemotaxis
type: Class
subclass of: GO_0030595
subclass of: GO_0036336
IAO_0000115: The movement of a dendritic cell in response to an external stimulus.

myeloid dendritic cell chemotaxis
type: Class
subclass of: dendritic cell chemotaxis
subclass of: GO_0097529
IAO_0000115: The movement of a myeloid dendritic cell in response to an external stimulus.

Langerhans cell chemotaxis
type: Class
subclass of: myeloid dendritic cell chemotaxis
IAO_0000115: The movement of a Langerhans cell in response to an external stimulus.

plasmacytoid dendritic cell chemotaxis
type: Class
subclass of: dendritic cell chemotaxis
IAO_0000115: The movement of a plasmacytoid dendritic cell in response to an external stimulus.

T cell tolerance induction to tumor cell
type: Class
subclass of: tolerance induction to tumor cell
subclass of: T cell mediated immune response to tumor cell
subclass of: peripheral T cell tolerance induction
IAO_0000115: A process of tolerance induction dependent on T cells which leads to immunological tolerance of a tumor.

antigen transcytosis by M cells in mucosal-associated lymphoid tissue
type: Class
subclass of: GO_0045056
subclass of: part-of-parent-2406
IAO_0000115: The process of antigen transcytosis carried out by M cells in the mucosal-associated lymphoid tissue (MALT). Transcytosis is the process of the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. M cells are specialized epithelia cells with a microfold structure that are adept at moving antigens from the gut lumen to antigen presenting cells in the MALT.
has exact synonym: antigen transcytosis by M cells in MALT
has exact synonym: antigen transport by M cells in MALT
has exact synonym: antigen transport by M cells in mucosal-associated lymphoid tissue

tolerance induction to tumor cell
type: Class
subclass of: immune response to tumor cell
subclass of: peripheral tolerance induction
IAO_0000115: A process of tolerance induction which leads to immunological tolerance of a tumor.

immunoglobulin transcytosis in epithelial cells
type: Class
subclass of: GO_0045056
IAO_0000115: The process of transporting immunoglobulin, via transcytosis, from one side of an epithelial cell to the other.

immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor
type: Class
subclass of: immunoglobulin transcytosis in epithelial cells
subclass of: part-of-parent-2385
IAO_0000115: The process of transporting polymeric IgA and polymeric IgM immunoglobulin, via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR), from the basolateral surface to apical surface of an epithelial cell. At the apical surface the immunoglobulin binding portion of the pIgRis cleaved and remains bound to the transported immunoglobulin as secretory component (SC). The same process is used for the transport and excretion of IgA immune complexes to the luminal surface of the mucosa.
has exact synonym: antibody transcytosis mediated by pIgR
has exact synonym: immunoglobulin transcytosis mediated by pIgR

IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor
type: Class
subclass of: immunoglobulin transcytosis in epithelial cells
IAO_0000115: The process of transporting IgG immunoglobulin, via transcytosis using the FcRn (also known as the neonatal Fc receptor; gene name FCGRT), from apical surface of an epithelial cell to the basolateral surface or vice versa depending on the location. This process is used for uptake of IgG from the milk in the gut in rodents, for transplacental transport of IgG from mother to embryo in humans, and for maintenance of a steady-state distribution of IgG across epithelial boundaries in general in adult mammals.
has exact synonym: IgG antibody transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor
has exact synonym: IgG immunoglobulin transcytosis in epithelial cells mediated by neonatal immunoglobulin receptor

B cell antigen processing and presentation mediated by B cell receptor uptake of antigen
type: Class
subclass of: B cell antigen processing and presentation
subclass of: antigen processing and presentation following receptor mediated endocytosis
IAO_0000115: B cell antigen processing and presentation which is initiated by uptake of antigen bound to the B cell receptor.
has exact synonym: B-cell antigen processing and presentation mediated by B cell receptor uptake of antigen
has exact synonym: B lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen
has exact synonym: B-lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen

immune response to tumor cell
type: Class
subclass of: response to tumor cell
subclass of: GO_0006955
IAO_0000115: An immune system process that functions in the response of an organism to a tumor cell.

T cell mediated cytotoxicity directed against tumor cell target
type: Class
subclass of: T cell mediated cytotoxicity
subclass of: T cell mediated immune response to tumor cell
IAO_0000115: The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
has exact synonym: T-cell mediated cytotoxicity directed against tumor cell target
has exact synonym: T lymphocyte mediated cytotoxicity directed against tumor cell target
has exact synonym: T-lymphocyte mediated cytotoxicity directed against tumor cell target

natural killer cell mediated cytotoxicity directed against tumor cell target
type: Class
subclass of: natural killer cell mediated immune response to tumor cell
subclass of: GO_0042267
IAO_0000115: The directed killing of a tumor cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
has exact synonym: NK cell mediated cytotoxicity directed against tumor cell target

B cell antigen processing and presentation following pinocytosis
type: Class
subclass of: B cell antigen processing and presentation
subclass of: antigen processing and presentation following pinocytosis
IAO_0000115: B cell antigen processing and presentation which is initiated by uptake of antigen via pinocytosis.
has exact synonym: B-cell antigen processing and presentation following pinocytosis
has exact synonym: B lymphocyte antigen processing and presentation following pinocytosis
has exact synonym: B-lymphocyte antigen processing and presentation following pinocytosis

natural killer cell mediated immune response to tumor cell
type: Class
subclass of: natural killer cell mediated immunity
subclass of: immune response to tumor cell
IAO_0000115: An immune response mediated by a natural killer cell triggered in response to the presence of a tumor cell.

T cell mediated immune response to tumor cell
type: Class
subclass of: immune response to tumor cell
subclass of: T cell mediated immunity
IAO_0000115: An immune response mediated by a T cell triggered in response to the presence of a tumor cell.

tolerance induction in urogenital tract
type: Class
subclass of: mucosal tolerance induction
IAO_0000115: Tolerance induction taking place in the urogenital tract.

immunoglobulin production in mucosal tissue
type: Class
subclass of: immunoglobulin production involved in immunoglobulin-mediated immune response
subclass of: part-of-parent-2385
IAO_0000115: The synthesis and release of immunoglobulin in the mucosal tissue.
has exact synonym: antibody production in mucosal tissue

mucosal tolerance induction
type: Class
subclass of: mucosal immune response
subclass of: tolerance induction to nonself antigen
IAO_0000115: Tolerance induction taking place in the mucosal tissues.

antigen processing and presentation of peptide antigen via MHC class Ib
type: Class
subclass of: antigen processing and presentation via MHC class Ib
subclass of: GO_0048002
IAO_0000115: The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC class Ib protein complex on its cell surface. The peptide antigen may originate from an endogenous or exogenous protein. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E family.
has exact synonym: peptide antigen processing and presentation via MHC class Ib

immune response-activating cell surface receptor signaling pathway
type: Class
subclass of: immune response-activating signal transduction
subclass of: immune response-regulating cell surface receptor signaling pathway
IAO_0000115: The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of a cell capable of activating or perpetuating an immune response.
has exact synonym: activation of immune response by cell surface receptor signaling pathway
has exact synonym: immune response-activating cell surface receptor signalling pathway

complement receptor mediated signaling pathway
type: Class
subclass of: immune response-activating cell surface receptor signaling pathway
IAO_0000115: The series of molecular signals generated as a consequence of a component of the complement pathway binding to a complement receptor. Such components include both whole complement proteins and fragments of complement proteins generated through the activity of the complement pathway.
has exact synonym: complement receptor mediated signalling pathway
has related synonym: immune response-regulating cell surface receptor signalling pathway

Fc receptor mediated stimulatory signaling pathway
type: Class
subclass of: immune response-activating cell surface receptor signaling pathway
IAO_0000115: The series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region.
has exact synonym: Fc-receptor mediated stimulatory signaling pathway
has exact synonym: Fc receptor mediated stimulatory signalling pathway

granuloma formation
type: Class
subclass of: immune effector process
subclass of: part-of-parent-2544
IAO_0000115: The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic.

immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
type: Class
subclass of: immune effector process
subclass of: immune response-regulating cell surface receptor signaling pathway
subclass of: part-of-parent-6909
IAO_0000115: An immune response-regulating cell surface receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.
has exact synonym: immune response-regulating cell surface receptor signalling pathway involved in phagocytosis
has exact synonym: phagocytosis triggered by activation of immune response cell surface activating receptor

immune complex clearance
type: Class
subclass of: immune effector process
IAO_0000115: A process directed at removing immune complexes from the body. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution.

immune complex clearance by erythrocytes
type: Class
subclass of: immune complex clearance
IAO_0000115: The process of immune complex clearance by erythrocytes. The process often starts with binding of complement receptor 1 (CR1) on the surface of erythrocytes to a complement coated immune complex. The complex bound to erythrocyte CR1 is then transported to the liver or spleen where it is presented to phagocytes. The process ends when the complex is removed from CR1, allowing the erythrocyte to return to general circulation.
has exact synonym: immune complex clearance by RBCs
has exact synonym: immune complex clearance by red blood cells

immune complex clearance by monocytes and macrophages
type: Class
subclass of: immune complex clearance
IAO_0000115: The process of immune complex clearance by monocytes or macrophages.

inflammatory response to antigenic stimulus
type: Class
subclass of: GO_0006954
subclass of: GO_0006955
IAO_0000115: An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes.

acute inflammatory response to antigenic stimulus
type: Class
subclass of: inflammatory response to antigenic stimulus
subclass of: acute inflammatory response
IAO_0000115: An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.

chronic inflammatory response to antigenic stimulus
type: Class
subclass of: inflammatory response to antigenic stimulus
subclass of: chronic inflammatory response
IAO_0000115: A chronic inflammatory response to an antigenic stimulus. A chronic inflammatory response persists indefinitely during days, weeks, or months in the life of an individual.

production of molecular mediator of immune response
type: Class
subclass of: immune system process
subclass of: GO_0010467
IAO_0000115: The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels.
has related synonym: production of cellular mediator of immune response

histamine secretion involved in inflammatory response
type: Class
subclass of: histamine secretion
subclass of: GO_0046879
subclass of: part-of-parent-2349
subclass of: part-of-parent-6954
IAO_0000115: The regulated release of histamine by a cell as part of an inflammatory response.
has related synonym: histamine secretion involved in acute inflammatory response

serotonin secretion involved in inflammatory response
type: Class
subclass of: serotonin secretion
subclass of: part-of-parent-2351
subclass of: part-of-parent-6954
IAO_0000115: The regulated release of serotonin by a cell as part of an inflammatory response.
has related synonym: serotonin release involved in inflammatory response
has related synonym: serotonin secretion involved in acute inflammatory response

leukocyte mediated immunity
type: Class
subclass of: immune effector process
IAO_0000115: Any process involved in the carrying out of an immune response by a leukocyte.
has related synonym: cell-mediated immune response
has related synonym: cellular immune response
has exact synonym: immune cell effector process
has exact synonym: immune cell mediated immunity
has exact synonym: leucocyte immune effector process
has exact synonym: leucocyte mediated immunity
has exact synonym: leukocyte immune effector process
replaces: GO_0019723
replaces: GO_0042087

myeloid leukocyte mediated immunity
type: Class
subclass of: leukocyte mediated immunity
IAO_0000115: Any process involved in the carrying out of an immune response by a myeloid leukocyte.
has exact synonym: myeloid leucocyte immune effector process
has exact synonym: myeloid leucocyte mediated immunity
has exact synonym: myeloid leukocyte immune effector process

type II hypersensitivity
type: Class
subclass of: myeloid leukocyte mediated immunity
subclass of: hypersensitivity
subclass of: GO_0016064
IAO_0000115: An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors.

neutrophil mediated immunity
type: Class
subclass of: myeloid leukocyte mediated immunity
IAO_0000115: Any process involved in the carrying out of an immune response by a neutrophil.

eosinophil mediated immunity
type: Class
subclass of: myeloid leukocyte mediated immunity
IAO_0000115: Any process involved in the carrying out of an immune response by an eosinophil.

mast cell mediated immunity
type: Class
subclass of: myeloid leukocyte mediated immunity
IAO_0000115: Any process involved in the carrying out of an immune response by a mast cell.

lymphocyte mediated immunity
type: Class
subclass of: leukocyte mediated immunity
IAO_0000115: Any process involved in the carrying out of an immune response by a lymphocyte.
has related synonym: cell-mediated immunity
has related synonym: cellular immune response

B cell antigen processing and presentation
type: Class
subclass of: GO_0019882
subclass of: part-of-parent-19724
IAO_0000115: The process in which a B cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
has exact synonym: B-cell antigen processing and presentation
has exact synonym: B lymphocyte antigen processing and presentation
has exact synonym: B-lymphocyte antigen processing and presentation

peripheral B cell tolerance induction
type: Class
subclass of: peripheral tolerance induction
subclass of: B cell tolerance induction
subclass of: GO_0019724
IAO_0000115: Tolerance induction of mature B cells in the peripheral lymphoid tissues: the blood, lymph nodes, spleen, and mucosal-associated lymphoid tissue.
has exact synonym: peripheral B-cell tolerance induction
has exact synonym: peripheral B lymphocyte tolerance induction
has exact synonym: peripheral B-lymphocyte tolerance induction

B cell receptor editing
type: Class
subclass of: GO_0016447
IAO_0000115: The process of replacing receptors on B cells, in which RAG gene expression allows continued light-chain gene rearrangement and expression of a new light change which combines with the previous heavy chain to form a new receptor.
has exact synonym: B-cell receptor editing
has exact synonym: B lymphocyte receptor editing
has exact synonym: B-lymphocyte receptor editing

peripheral B cell anergy
type: Class
subclass of: B cell anergy
subclass of: part-of-parent-2451
IAO_0000115: Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in peripheral B cells.
has exact synonym: peripheral B-cell anergy
has exact synonym: peripheral B lymphocyte anergy
has exact synonym: peripheral B-lymphocyte anergy

peripheral B cell deletion
type: Class
subclass of: B cell deletion
subclass of: part-of-parent-2451
IAO_0000115: The deletion of B cells by apoptotic process occurring as part of peripheral tolerance induction and B cell selection.
has exact synonym: peripheral B-cell deletion
has exact synonym: peripheral B lymphocyte deletion
has exact synonym: peripheral B-lymphocyte deletion

humoral immune response mediated by circulating immunoglobulin
type: Class
subclass of: GO_0006959
subclass of: GO_0016064
IAO_0000115: An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.
has exact synonym: circulating antibody mediated immune response
has exact synonym: circulating immunoglobulin mediated immune response
has related synonym: humoral defence mechanism
has exact synonym: humoral immune response mediated by circulating antibody

T cell mediated immunity
type: Class
subclass of: lymphocyte mediated immunity
subclass of: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
IAO_0000115: Any process involved in the carrying out of an immune response by a T cell.
has related synonym: cell-mediated immunity
has related synonym: cellular immune response
has exact synonym: T-cell mediated immunity
has exact synonym: T lymphocyte mediated immunity
has exact synonym: T-lymphocyte mediated immunity

T cell antigen processing and presentation
type: Class
subclass of: GO_0019882
subclass of: part-of-parent-2456
IAO_0000115: The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
has exact synonym: T-cell antigen processing and presentation
has exact synonym: T lymphocyte antigen processing and presentation
has exact synonym: T-lymphocyte antigen processing and presentation

peripheral T cell tolerance induction
type: Class
subclass of: T cell mediated immunity
subclass of: peripheral tolerance induction
subclass of: T cell tolerance induction
IAO_0000115: Tolerance induction of T cells in the periphery, in this case, any location in the body other than the thymus.
has exact synonym: peripheral T-cell tolerance induction
has exact synonym: peripheral T lymphocyte tolerance induction
has exact synonym: peripheral T-lymphocyte tolerance induction

adaptive immune response based on somatic recombination of immune receptors built from leucine-rich repeat domains
type: Class
subclass of: adaptive immune response
IAO_0000115: An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of variable lymphocyte receptors (VLR) incorporating leucine-rich repeat (LRR) domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Examples of this process are found in jawless fish, including the lampreys (Petromyzontidae) and hagfishes (Myxinidae).
has exact synonym: adaptive immune response based on somatic recombination of variable lymphocyte receptors built from leucine-rich repeat domains
has exact synonym: adaptive immune response based on somatic recombination of VLR built from LRR domains
has exact synonym: adaptive immune response in jawless fish

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
type: Class
subclass of: adaptive immune response
IAO_0000115: An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus.

tolerance induction dependent upon immune response
type: Class
subclass of: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: tolerance induction
IAO_0000115: Tolerance induction dependent upon an immune response, typically a response by a mature T or B cell in the periphery resulting tolerance towards an antigen via induction of anergy, cellular deletion, or regulatory T cell activation.
has exact synonym: immune response-dependent tolerance induction

tolerance induction to nonself antigen
type: Class
subclass of: tolerance induction dependent upon immune response
IAO_0000115: Tolerance induction in response to nonself antigens.

central tolerance induction to nonself antigen
type: Class
subclass of: tolerance induction to nonself antigen
subclass of: central tolerance induction
IAO_0000115: Tolerance induction to nonself antigens in the central lymphoid organs.

peripheral tolerance induction to nonself antigen
type: Class
subclass of: tolerance induction to nonself antigen
subclass of: peripheral tolerance induction
IAO_0000115: Tolerance induction to nonself antigens in the periphery.

peripheral tolerance induction
type: Class
subclass of: tolerance induction dependent upon immune response
IAO_0000115: Tolerance induction in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues.

peripheral tolerance induction to self antigen
type: Class
subclass of: peripheral tolerance induction
subclass of: tolerance induction to self antigen
IAO_0000115: Tolerance induction to self antigens in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues.

germinal center formation
type: Class
subclass of: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: GO_0048646
IAO_0000115: The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation.

dendritic cell antigen processing and presentation
type: Class
subclass of: GO_0019882
IAO_0000115: The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.

myeloid dendritic cell antigen processing and presentation
type: Class
subclass of: dendritic cell antigen processing and presentation
IAO_0000115: The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.

plasmacytoid dendritic cell antigen processing and presentation
type: Class
subclass of: dendritic cell antigen processing and presentation
IAO_0000115: The process in which a plasmacytoid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.

monocyte antigen processing and presentation
type: Class
subclass of: GO_0019882
IAO_0000115: The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.

macrophage antigen processing and presentation
type: Class
subclass of: GO_0019882
IAO_0000115: The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.

non-professional antigen presenting cell antigen processing and presentation
type: Class
subclass of: GO_0019882
IAO_0000115: The process in which a non-professional antigen presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. Non-professional antigen presenting cells include all cell types but dendritic cells, B cells, T cells, monocytes, macrophages, and neutrophils.

antigen processing and presentation of peptide antigen via MHC class I
type: Class
subclass of: GO_0048002
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules.
has exact synonym: peptide antigen processing and presentation via MHC class I

antigen processing and presentation via MHC class Ib
type: Class
subclass of: GO_0019882
IAO_0000115: The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families.

antigen processing and presentation of endogenous peptide antigen via MHC class Ib
type: Class
subclass of: antigen processing and presentation of peptide antigen via MHC class Ib
subclass of: antigen processing and presentation of endogenous peptide antigen
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.
has exact synonym: endogenous peptide antigen processing and presentation via MHC class Ib

antigen processing and presentation of exogenous peptide antigen via MHC class Ib
type: Class
subclass of: antigen processing and presentation of peptide antigen via MHC class Ib
subclass of: antigen processing and presentation of exogenous peptide antigen
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.
has exact synonym: exogenous peptide antigen processing and presentation via MHC class Ib

antigen processing and presentation of exogenous peptide antigen
type: Class
subclass of: GO_0019884
subclass of: GO_0048002
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell.
has exact synonym: exogenous peptide antigen processing and presentation

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
type: Class
subclass of: GO_0042590
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules.
has related synonym: cross presentation
has related synonym: cross-presentation
has exact synonym: exogenous peptide antigen processing and presentation via MHC class I, TAP-dependent
has exact synonym: TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class I
has exact synonym: TAP-dependent exogenous peptide antigen processing and presentation via MHC class I

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
type: Class
subclass of: GO_0042590
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class I here refers to classical class I molecules.
has related synonym: cross presentation
has related synonym: cross-presentation
has exact synonym: exogenous peptide antigen processing and presentation via MHC class I, TAP-independent
has exact synonym: TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class I
has exact synonym: TAP-independent exogenous peptide antigen processing and presentation via MHC class I

antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
type: Class
subclass of: antigen processing and presentation of exogenous peptide antigen via MHC class Ib
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.
has exact synonym: exogenous peptide antigen processing and presentation via MHC class Ib, TAP-dependent
has exact synonym: TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class Ib
has exact synonym: TAP-dependent exogenous peptide antigen processing and presentation via MHC class Ib

antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-independent
type: Class
subclass of: antigen processing and presentation of exogenous peptide antigen via MHC class Ib
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.
has exact synonym: exogenous peptide antigen processing and presentation via MHC class Ib, TAP-independent
has exact synonym: TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class Ib
has exact synonym: TAP-independent exogenous peptide antigen processing and presentation via MHC class Ib

antigen processing and presentation of endogenous peptide antigen
type: Class
subclass of: GO_0019883
subclass of: GO_0048002
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell.
has exact synonym: endogenous peptide antigen processing and presentation

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway
type: Class
subclass of: GO_0019885
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER. Class I here refers to classical class I molecules.
has exact synonym: endogenous peptide antigen processing and presentation via MHC class I via ER pathway

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
type: Class
subclass of: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-dependent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following TAP-dependent transport from the cytosol. Class I here refers to classical class I molecules.
has exact synonym: endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-dependent
has exact synonym: TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway
has exact synonym: TAP-dependent endogenous peptide antigen processing and presentation via MHC class I via ER pathway

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
type: Class
subclass of: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-independent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following transport from the cytosol via a TAP-independent pathway. Class I here refers to classical class I molecules.
has exact synonym: endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-independent
has exact synonym: TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway
has exact synonym: TAP-independent endogenous peptide antigen processing and presentation via MHC class I via ER pathway

antigen processing and presentation of endogenous peptide antigen via MHC class I via endolysosomal pathway
type: Class
subclass of: GO_0019885
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in an endolysosome. Class I here refers to classical class I molecules.
has exact synonym: endogenous peptide antigen processing and presentation via MHC class I via endolysosomal pathway

antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway
type: Class
subclass of: antigen processing and presentation of endogenous peptide antigen via MHC class Ib
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class Ib molecule in the ER. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.
has exact synonym: endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway

antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
type: Class
subclass of: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.
has exact synonym: endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-dependent
has exact synonym: TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway
has exact synonym: TAP-dependent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway

antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-independent
type: Class
subclass of: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.
has exact synonym: endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-independent
has exact synonym: TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway
has exact synonym: TAP-independent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway

antigen processing and presentation of endogenous peptide antigen via MHC class II
type: Class
subclass of: antigen processing and presentation of endogenous peptide antigen
subclass of: antigen processing and presentation of peptide antigen via MHC class II
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.
has exact synonym: endogenous peptide antigen processing and presentation via MHC class II

peptide antigen assembly with MHC class Ib protein complex
type: Class
subclass of: peptide antigen assembly with MHC protein complex
subclass of: part-of-parent-2398
subclass of: part-of-parent-2428
IAO_0000115: The binding of a peptide antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.

lipid antigen assembly with MHC class Ib protein complex
type: Class
subclass of: GO_0065005
subclass of: part-of-parent-2398
subclass of: part-of-parent-48003
IAO_0000115: The binding of a lipid antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 gene family.

lipid antigen transport
type: Class
subclass of: GO_0006869
subclass of: part-of-parent-48003
IAO_0000115: The directed movement of a lipid antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

antigen processing and presentation of peptide antigen via MHC class II
type: Class
subclass of: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
subclass of: GO_0048002
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.
has exact synonym: peptide antigen processing and presentation via MHC class II

proteolysis associated with antigen processing and presentation
type: Class
subclass of: GO_0051603
subclass of: part-of-parent-48002
IAO_0000115: The hydrolysis of a peptide bond or bonds within a protein contributing to antigen processing and presentation.

proteasomal proteolysis associated with antigen processing and presentation
type: Class
subclass of: proteolysis associated with antigen processing and presentation
IAO_0000115: The hydrolysis of a peptide bond or bonds within a protein by the proteasome complex contributing to antigen processing and presentation.

proteolysis within endoplasmic reticulum associated with antigen processing and presentation
type: Class
subclass of: proteolysis associated with antigen processing and presentation
IAO_0000115: The hydrolysis of a peptide bond or bonds within a protein by ER resident proteases contributing to antigen processing and presentation.
has exact synonym: endoplasmic reticulum proteolysis associated with antigen processing and presentation
has exact synonym: ER proteolysis associated with antigen processing and presentation
has exact synonym: proteolysis within ER associated with antigen processing and presentation

proteolysis within endosome associated with antigen processing and presentation
type: Class
subclass of: proteolysis associated with antigen processing and presentation
IAO_0000115: The hydrolysis of a peptide bond or bonds within a protein by endosomal resident proteases contributing to antigen processing and presentation.
has exact synonym: endosomal proteolysis associated with antigen processing and presentation

proteolysis within lysosome associated with antigen processing and presentation
type: Class
subclass of: proteolysis associated with antigen processing and presentation
IAO_0000115: The hydrolysis of a peptide bond or bonds within a protein by lysosomal resident proteases contributing to antigen processing and presentation.
has exact synonym: lysosomal proteolysis associated with antigen processing and presentation

peptide antigen assembly with MHC protein complex
type: Class
subclass of: GO_0065003
subclass of: part-of-parent-2396
subclass of: part-of-parent-48002
IAO_0000115: The binding of a peptide to the antigen binding groove of an MHC protein complex.

peptide antigen assembly with MHC class I protein complex
type: Class
subclass of: peptide antigen assembly with MHC protein complex
subclass of: part-of-parent-2397
subclass of: part-of-parent-2474
IAO_0000115: The binding of a peptide to the antigen binding groove of an MHC class I protein complex. Class I here refers to classical class I molecules.

peptide antigen assembly with MHC class II protein complex
type: Class
subclass of: peptide antigen assembly with MHC protein complex
subclass of: part-of-parent-2399
subclass of: part-of-parent-2495
IAO_0000115: The binding of a peptide to the antigen binding groove of an MHC class II protein complex.

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
type: Class
subclass of: GO_0019882
IAO_0000115: The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex.
has exact synonym: peptide or polysaccharide antigen processing and presentation of via MHC class II

antigen processing and presentation of polysaccharide antigen via MHC class II
type: Class
subclass of: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
IAO_0000115: The process in which an antigen-presenting cell expresses a polysaccharide antigen on its cell surface in association with an MHC class II protein complex.
has exact synonym: polysaccharide antigen processing and presentation via MHC class II

tolerance induction
type: Class
subclass of: immune system process
subclass of: part-of-parent-2520
IAO_0000115: A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it.

central tolerance induction
type: Class
subclass of: tolerance induction
IAO_0000115: Tolerance induction in the central lymphoid organs: the thymus and bone marrow.

central tolerance induction to self antigen
type: Class
subclass of: central tolerance induction
subclass of: tolerance induction to self antigen
IAO_0000115: Tolerance induction in the central lymphoid organs directed at self antigens.

central B cell tolerance induction
type: Class
subclass of: central tolerance induction
subclass of: B cell tolerance induction
IAO_0000115: Tolerance induction of B cells in the bone marrow.
has exact synonym: central B-cell tolerance induction
has exact synonym: central B lymphocyte tolerance induction
has exact synonym: central B-lymphocyte tolerance induction

central B cell receptor editing
type: Class
subclass of: B cell receptor editing
IAO_0000115: Receptor editing occurring in B cells in the bone marrow.
has exact synonym: central B-cell receptor editing
has exact synonym: central B lymphocyte receptor editing
has exact synonym: central B-lymphocyte receptor editing

central T cell tolerance induction
type: Class
subclass of: central tolerance induction
subclass of: T cell tolerance induction
IAO_0000115: Tolerance induction of T cells in the thymus.
has exact synonym: central T-cell tolerance induction
has exact synonym: central T lymphocyte tolerance induction
has exact synonym: central T-lymphocyte tolerance induction

tolerance induction to self antigen
type: Class
subclass of: tolerance induction
IAO_0000115: Tolerance induction directed at self antigens.

B cell tolerance induction
type: Class
subclass of: tolerance induction
IAO_0000115: A process involving any mechanism for tolerance induction in B cells.
has exact synonym: B-cell tolerance induction
has exact synonym: B lymphocyte tolerance induction
has exact synonym: B-lymphocyte tolerance induction

B cell anergy
type: Class
subclass of: lymphocyte anergy
subclass of: B cell tolerance induction
IAO_0000115: Any process contributing to anergy in B cells, a state of functional inactivation which is part of B cell tolerance induction.
has exact synonym: B-cell anergy
has exact synonym: B lymphocyte anergy
has exact synonym: B-lymphocyte anergy

B cell deletion
type: Class
subclass of: B cell apoptotic process
subclass of: GO_1902742
subclass of: part-of-parent-2514
IAO_0000115: The apoptotic death of B cells which is part of B cell tolerance induction.
has exact synonym: B-cell deletion
has exact synonym: B lymphocyte deletion
has exact synonym: B-lymphocyte deletion

T cell tolerance induction
type: Class
subclass of: tolerance induction
IAO_0000115: A process involving any mechanism for tolerance induction in T cells.
has exact synonym: T-cell tolerance induction
has exact synonym: T lymphocyte tolerance induction
has exact synonym: T-lymphocyte tolerance induction

lymphocyte chemotaxis across high endothelial venule
type: Class
subclass of: GO_0048247
IAO_0000115: The movement of a lymphocyte to cross a high endothelial venule in response to an external stimulus.

natural killer cell tolerance induction
type: Class
subclass of: tolerance induction
IAO_0000115: Tolerance induction of natural killer cells.
has exact synonym: NK cell tolerance induction

immune system development
type: Class
subclass of: immune system process
subclass of: GO_0048731
IAO_0000115: The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

leukocyte differentiation
type: Class
subclass of: GO_0030154
subclass of: part-of-parent-30097
IAO_0000115: The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.
has exact synonym: immune cell differentiation
has exact synonym: leucocyte differentiation

leukocyte migration involved in immune response
type: Class
subclass of: immune effector process
subclass of: GO_0050900
subclass of: part-of-parent-6955
IAO_0000115: The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response.
has exact synonym: immune cell migration during immune response
has exact synonym: immune cell trafficking during immune response
has exact synonym: leucocyte migration during immune response
has exact synonym: leucocyte trafficking during immune response
has exact synonym: leukocyte trafficking during immune response

leukocyte migration involved in inflammatory response
type: Class
subclass of: GO_0050900
subclass of: part-of-parent-6954
IAO_0000115: The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response.
has related synonym: immune cell migration during inflammatory response
has related synonym: immune cell trafficking during inflammatory response
has related synonym: leucocyte migration during inflammatory response
has related synonym: leucocyte trafficking during inflammatory response
has related synonym: leukocyte migration during inflammatory response
has related synonym: leukocyte trafficking during inflammatory response

hypersensitivity
type: Class
subclass of: acute inflammatory response to antigenic stimulus
IAO_0000115: An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system.
has related synonym: hypersensitivity response

acute inflammatory response to non-antigenic stimulus
type: Class
subclass of: acute inflammatory response
IAO_0000115: An acute inflammatory response to non-antigenic stimuli such as heat or physical trauma.

acute inflammatory response
type: Class
subclass of: GO_0006954
IAO_0000115: Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.

vasodilation involved in acute inflammatory response
type: Class
subclass of: GO_0042311
subclass of: part-of-parent-2526
IAO_0000115: An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure contributing to an acute inflammatory response.
has related synonym: vasodilation during acute inflammatory response

regulation of vascular permeability involved in acute inflammatory response
type: Class
subclass of: GO_0043114
subclass of: part-of-parent-2526
IAO_0000115: Any process that modulates the extent to which blood vessels can be pervaded by fluid contributing to an acute inflammatory response.
has related synonym: regulation of vascular permeability during acute inflammatory response

regulation of plasma kallikrein-kinin cascade
type: Class
subclass of: regulation of kinin cascade
IAO_0000115: Any process that modulates the frequency, rate, or extent of the plasma kallikrein-kinin cascade.

regulation of systemic arterial blood pressure involved in acute-phase response
type: Class
subclass of: regulation of systemic arterial blood pressure
subclass of: part-of-parent-6953
IAO_0000115: Any process that modulates the force with which blood travels through the circulatory system that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein.
has related synonym: blood pressure regulation during acute phase response
has related synonym: regulation of systemic arterial blood pressure during acute phase response

regulation of heart contraction involved in acute-phase response
type: Class
subclass of: GO_0008016
subclass of: part-of-parent-6953
IAO_0000115: Any process that modulates the frequency, rate or extent of heart contraction that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein.
has related synonym: regulation of cardiac contraction during acute phase response
has related synonym: regulation of heart contraction during acute phase response

production of molecular mediator involved in inflammatory response
type: Class
subclass of: GO_0032501
subclass of: part-of-parent-6954
IAO_0000115: The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels.
has related synonym: production of cellular mediator of acute inflammation
has related synonym: production of molecular mediator involved in acute inflammatory response

lysosomal enzyme secretion involved in inflammatory response
type: Class
subclass of: GO_0033299
subclass of: part-of-parent-2393
subclass of: part-of-parent-6954
IAO_0000115: The regulated release of lysosomal enzymes by a cell as part of an inflammatory response.
has related synonym: lysosomal enzyme secretion involved in acute inflammatory response
has related synonym: secretion of lysosomal enzymes involved in acute inflammatory response
has exact synonym: secretion of lysosomal enzymes involved in inflammatory response

cytokine production involved in inflammatory response
type: Class
subclass of: cytokine production
subclass of: production of molecular mediator involved in inflammatory response
subclass of: part-of-parent-6954
IAO_0000115: The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
has related synonym: cytokine production involved in acute inflammatory response

respiratory burst involved in inflammatory response
type: Class
subclass of: production of molecular mediator involved in inflammatory response
subclass of: respiratory burst involved in defense response
subclass of: part-of-parent-6954
IAO_0000115: A phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus as part of an inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels.
has related synonym: oxidative burst during acute inflammatory response
has related synonym: production of reactive oxygen species during acute inflammatory response
has related synonym: respiratory burst involved in acute inflammatory response

nitric oxide production involved in inflammatory response
type: Class
subclass of: production of molecular mediator involved in inflammatory response
IAO_0000115: The synthesis or release of nitric oxide following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
has related synonym: nitric oxide production involved in acute inflammatory response
has related synonym: production of nitric oxide involved in acute inflammatory response
has exact synonym: production of nitric oxide involved in inflammatory response

arachidonic acid metabolite production involved in inflammatory response
type: Class
subclass of: production of molecular mediator involved in inflammatory response
IAO_0000115: The synthesis or release of products of arachidonic acid metabolism following a stimulus as part of an inflammatory response, resulting in an increase in their intracellular or extracellular levels.
has related synonym: arachidonic acid metabolite production involved in acute inflammatory response
has related synonym: production of arachidonic acid metabolites involved in acute inflammatory response
has exact synonym: production of arachidonic acid metabolites involved in inflammatory response

prostaglandin production involved in inflammatory response
type: Class
subclass of: arachidonic acid metabolite production involved in inflammatory response
IAO_0000115: The synthesis or release of any prostaglandin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
has related synonym: prostaglandin production involved in acute inflammatory response

leukotriene production involved in inflammatory response
type: Class
subclass of: arachidonic acid metabolite production involved in inflammatory response
IAO_0000115: The synthesis or release of any leukotriene following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
has related synonym: leukotriene production involved in acute inflammatory response

activation of plasma proteins involved in acute inflammatory response
type: Class
subclass of: GO_0016485
subclass of: part-of-parent-2526
IAO_0000115: Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.

Factor XII activation
type: Class
subclass of: regulation of acute inflammatory response
subclass of: GO_0010954
subclass of: part-of-parent-2353
IAO_0000115: Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade.
has exact synonym: Hageman factor activation

activation of blood coagulation via clotting cascade
type: Class
subclass of: GO_0030194
subclass of: part-of-parent-2526
IAO_0000115: Any process that initiates the clotting cascade of blood coagulation, a cascade of plasma enzymes that is triggered following damage to blood vessels, leading to formation of a clot.
has exact synonym: activation of clotting cascade

chronic inflammatory response
type: Class
subclass of: GO_0006954
IAO_0000115: Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response.

chronic inflammatory response to non-antigenic stimulus
type: Class
subclass of: chronic inflammatory response
IAO_0000115: A chronic inflammatory response to a non-antigenic stimulus such as heat or physical trauma.

negative regulation of tissue kallikrein-kinin cascade
type: Class
subclass of: negative regulation of kinin cascade
subclass of: regulation of tissue kallikrein-kinin cascade
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of the tissue kallikrein-kinin cascade.
has exact synonym: downregulation of tissue kallikrein-kinin cascade
has exact synonym: down regulation of tissue kallikrein-kinin cascade
has exact synonym: down-regulation of tissue kallikrein-kinin cascade
has related synonym: inhibition of tissue kallikrein-kinin cascade
has exact synonym: negative regulation of glandular kallikrein-kinin cascade

positive regulation of tissue kallikrein-kinin cascade
type: Class
subclass of: positive regulation of kinin cascade
subclass of: regulation of tissue kallikrein-kinin cascade
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of the tissue kallikrein-kinin cascade.
has related synonym: activation of tissue kallikrein-kinin cascade
has exact synonym: positive regulation of glandular kallikrein-kinin cascade
has related synonym: stimulation of tissue kallikrein-kinin cascade
has exact synonym: upregulation of tissue kallikrein-kinin cascade
has exact synonym: up regulation of tissue kallikrein-kinin cascade
has exact synonym: up-regulation of tissue kallikrein-kinin cascade

monocyte chemotaxis
type: Class
subclass of: GO_0030595
subclass of: GO_0071674
subclass of: GO_0097529
IAO_0000115: The movement of a monocyte in response to an external stimulus.

negative regulation of plasma kallikrein-kinin cascade
type: Class
subclass of: negative regulation of kinin cascade
subclass of: regulation of plasma kallikrein-kinin cascade
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of the plasma kallikrein-kinin cascade.
has exact synonym: downregulation of plasma kallikrein-kinin cascade
has exact synonym: down regulation of plasma kallikrein-kinin cascade
has exact synonym: down-regulation of plasma kallikrein-kinin cascade
has related synonym: inhibition of plasma kallikrein-kinin cascade

positive regulation of plasma kallikrein-kinin cascade
type: Class
subclass of: positive regulation of kinin cascade
subclass of: regulation of plasma kallikrein-kinin cascade
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of the plasma kallikrein-kinin cascade.
has related synonym: activation of plasma kallikrein-kinin cascade
has related synonym: stimulation of plasma kallikrein-kinin cascade
has exact synonym: upregulation of plasma kallikrein-kinin cascade
has exact synonym: up regulation of plasma kallikrein-kinin cascade
has exact synonym: up-regulation of plasma kallikrein-kinin cascade

mast cell chemotaxis
type: Class
subclass of: GO_0030595
subclass of: GO_0097531
IAO_0000115: The movement of a mast cell in response to an external stimulus.

serotonin secretion by mast cell
type: Class
subclass of: serotonin secretion involved in inflammatory response
subclass of: GO_0051649
subclass of: GO_0140029
subclass of: part-of-parent-43303
IAO_0000115: The regulated release of serotonin by a mast cell or group of mast cells.
has related synonym: serotonin release by mast cell

histamine secretion by mast cell
type: Class
subclass of: histamine secretion involved in inflammatory response
subclass of: GO_0051649
subclass of: GO_0140029
subclass of: part-of-parent-43303
IAO_0000115: The regulated release of histamine by a mast cell or group of mast cells.

serotonin secretion by platelet
type: Class
subclass of: serotonin secretion involved in inflammatory response
subclass of: GO_0051649
subclass of: GO_0140029
subclass of: part-of-parent-2576
IAO_0000115: The regulated release of serotonin by a platelet or group of platelets.
has related synonym: serotonin release by platelet

histamine secretion by platelet
type: Class
subclass of: histamine secretion involved in inflammatory response
subclass of: GO_0051649
subclass of: GO_0140029
subclass of: part-of-parent-2576
IAO_0000115: The regulated release of histamine by a platelet or group of platelets.

serotonin secretion by basophil
type: Class
subclass of: serotonin secretion involved in inflammatory response
subclass of: GO_0051649
subclass of: GO_0140029
subclass of: part-of-parent-2561
IAO_0000115: The regulated release of serotonin by a basophil or group of basophils.
has related synonym: serotonin release by basophil

histamine secretion by basophil
type: Class
subclass of: histamine secretion involved in inflammatory response
subclass of: GO_0051649
subclass of: GO_0140029
subclass of: part-of-parent-2561
IAO_0000115: The regulated release of histamine by a basophil or group of basophils.

type I hypersensitivity mediated by mast cells
type: Class
subclass of: mast cell mediated immunity
subclass of: GO_0016068
IAO_0000115: An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.

type I hypersensitivity mediated by basophils
type: Class
subclass of: basophil mediated immunity
subclass of: GO_0016068
IAO_0000115: An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.

basophil mediated immunity
type: Class
subclass of: myeloid leukocyte mediated immunity
IAO_0000115: Any process involved in the carrying out of an immune response by a basophil.

basophil degranulation
type: Class
subclass of: basophil activation involved in immune response
subclass of: GO_0043299
subclass of: part-of-parent-2560
IAO_0000115: The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a basophil.

somatic diversification of immune receptors via germline recombination within a single locus
type: Class
subclass of: somatic diversification of immune receptors
subclass of: GO_0016444
IAO_0000115: The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus.

somatic diversification of immune receptors via alternate splicing
type: Class
subclass of: somatic diversification of immune receptors
IAO_0000115: The process in which immune receptor genes are diversified through alternate splicing.

alternate splicing of immunoglobulin genes
type: Class
subclass of: somatic diversification of immune receptors via alternate splicing
subclass of: GO_0016445
IAO_0000115: The generation of alternate transcripts of immunoglobulin genes through alternate splicing of exons.
has exact synonym: alternate splicing of antibody genes

somatic diversification of immune receptors via gene conversion
type: Class
subclass of: somatic diversification of immune receptors
subclass of: GO_0016444
IAO_0000115: The process in which immune receptor genes are diversified through gene conversion.

somatic diversification of immune receptors via somatic mutation
type: Class
subclass of: somatic diversification of immune receptors
IAO_0000115: The process in which immune receptor genes are diversified through somatic mutation.

somatic diversification of FREP-based immune receptors
type: Class
subclass of: somatic diversification of immune receptors
IAO_0000115: The process that results in the generation of sequence diversity of the FREP-based immune receptors of snails.

somatic diversification of T cell receptor genes
type: Class
subclass of: somatic diversification of immune receptors
subclass of: part-of-parent-30217
IAO_0000115: The somatic process that results in the generation of sequence diversity of T cell receptor genes.
has exact synonym: somatic diversification of TCR genes

somatic diversification of immune receptors by N region addition
type: Class
subclass of: somatic diversification of immune receptors
IAO_0000115: The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin and T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the immune receptor gene.

somatic diversification of immunoglobulin genes by N region addition
type: Class
subclass of: somatic diversification of immune receptors by N region addition
subclass of: GO_0016445
subclass of: part-of-parent-16447
IAO_0000115: The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin genes. N regions are found at the V-D and D-J recombinational junctions.
has exact synonym: somatic diversification of antibody genes by N region addition

somatic diversification of T cell receptor genes by N region addition
type: Class
subclass of: somatic diversification of T cell receptor genes
subclass of: somatic diversification of immune receptors by N region addition
subclass of: part-of-parent-2681
IAO_0000115: The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the T cell receptor gene.
has exact synonym: somatic diversification of TCR genes by N region addition

pro-T cell differentiation
type: Class
subclass of: lymphoid progenitor cell differentiation
subclass of: part-of-parent-30217
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed.
has exact synonym: pro-T lymphocyte differentiation

myeloid leukocyte differentiation
type: Class
subclass of: leukocyte differentiation
subclass of: GO_0030099
IAO_0000115: The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage.
has exact synonym: myeloid leucocyte differentiation

thrombocyte differentiation
type: Class
subclass of: GO_0030099
IAO_0000115: The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis.

basophil chemotaxis
type: Class
subclass of: GO_0071621
IAO_0000115: The movement of a basophil in response to an external stimulus.

platelet degranulation
type: Class
subclass of: GO_0045055
subclass of: GO_0051649
IAO_0000115: The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
has exact synonym: platelet exocytosis

regulation of antigen processing and presentation
type: Class
subclass of: regulation of immune system process
IAO_0000115: Any process that modulates the frequency, rate, or extent of antigen processing and presentation.

negative regulation of antigen processing and presentation
type: Class
subclass of: regulation of antigen processing and presentation
subclass of: negative regulation of immune system process
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation.
has exact synonym: downregulation of antigen processing and presentation
has exact synonym: down regulation of antigen processing and presentation
has exact synonym: down-regulation of antigen processing and presentation
has related synonym: inhibition of antigen processing and presentation

positive regulation of antigen processing and presentation
type: Class
subclass of: regulation of antigen processing and presentation
subclass of: positive regulation of immune system process
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation.
has related synonym: activation of antigen processing and presentation
has related synonym: stimulation of antigen processing and presentation
has exact synonym: upregulation of antigen processing and presentation
has exact synonym: up regulation of antigen processing and presentation
has exact synonym: up-regulation of antigen processing and presentation

regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
type: Class
subclass of: regulation of antigen processing and presentation
IAO_0000115: Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.
has exact synonym: regulation of peptide or polysaccharide antigen processing and presentation via MHC class II

negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
type: Class
subclass of: negative regulation of antigen processing and presentation
subclass of: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.
has exact synonym: downregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
has exact synonym: down regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
has exact synonym: down-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
has related synonym: inhibition of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
has exact synonym: negative regulation of peptide or polysaccharide antigen processing and presentation via MHC class II

positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
type: Class
subclass of: positive regulation of antigen processing and presentation
subclass of: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.
has related synonym: activation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
has exact synonym: positive regulation of peptide or polysaccharide antigen processing and presentation via MHC class II
has related synonym: stimulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
has exact synonym: upregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
has exact synonym: up regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
has exact synonym: up-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

regulation of antigen processing and presentation of peptide antigen
type: Class
subclass of: regulation of antigen processing and presentation
IAO_0000115: Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen.
has exact synonym: regulation of peptide antigen processing and presentation

negative regulation of antigen processing and presentation of peptide antigen
type: Class
subclass of: negative regulation of antigen processing and presentation
subclass of: regulation of antigen processing and presentation of peptide antigen
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen.
has exact synonym: downregulation of antigen processing and presentation of peptide antigen
has exact synonym: down regulation of antigen processing and presentation of peptide antigen
has exact synonym: down-regulation of antigen processing and presentation of peptide antigen
has related synonym: inhibition of antigen processing and presentation of peptide antigen
has exact synonym: negative regulation of peptide antigen processing and presentation

positive regulation of antigen processing and presentation of peptide antigen
type: Class
subclass of: positive regulation of antigen processing and presentation
subclass of: regulation of antigen processing and presentation of peptide antigen
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen.
has related synonym: activation of antigen processing and presentation of peptide antigen
has exact synonym: positive regulation of peptide antigen processing and presentation
has related synonym: stimulation of antigen processing and presentation of peptide antigen
has exact synonym: upregulation of antigen processing and presentation of peptide antigen
has exact synonym: up regulation of antigen processing and presentation of peptide antigen
has exact synonym: up-regulation of antigen processing and presentation of peptide antigen

regulation of antigen processing and presentation of peptide antigen via MHC class II
type: Class
subclass of: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
subclass of: regulation of antigen processing and presentation of peptide antigen
IAO_0000115: Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II.
has exact synonym: regulation of peptide antigen processing and presentation via MHC class II

negative regulation of antigen processing and presentation of peptide antigen via MHC class II
type: Class
subclass of: negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
subclass of: negative regulation of antigen processing and presentation of peptide antigen
subclass of: regulation of antigen processing and presentation of peptide antigen via MHC class II
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II.
has exact synonym: downregulation of antigen processing and presentation of peptide antigen via MHC class II
has exact synonym: down regulation of antigen processing and presentation of peptide antigen via MHC class II
has exact synonym: down-regulation of antigen processing and presentation of peptide antigen via MHC class II
has related synonym: inhibition of antigen processing and presentation of peptide antigen via MHC class II
has exact synonym: negative regulation of peptide antigen processing and presentation via MHC class II

positive regulation of antigen processing and presentation of peptide antigen via MHC class II
type: Class
subclass of: positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
subclass of: positive regulation of antigen processing and presentation of peptide antigen
subclass of: regulation of antigen processing and presentation of peptide antigen via MHC class II
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II.
has related synonym: activation of antigen processing and presentation of peptide antigen via MHC class II
has exact synonym: positive regulation of peptide antigen processing and presentation via MHC class II
has related synonym: stimulation of antigen processing and presentation of peptide antigen via MHC class II
has exact synonym: upregulation of antigen processing and presentation of peptide antigen via MHC class II
has exact synonym: up regulation of antigen processing and presentation of peptide antigen via MHC class II
has exact synonym: up-regulation of antigen processing and presentation of peptide antigen via MHC class II

regulation of antigen processing and presentation of peptide antigen via MHC class I
type: Class
subclass of: regulation of antigen processing and presentation of peptide antigen
IAO_0000115: Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I.
has exact synonym: regulation of peptide antigen processing and presentation via MHC class I

negative regulation of antigen processing and presentation of peptide antigen via MHC class I
type: Class
subclass of: negative regulation of antigen processing and presentation of peptide antigen
subclass of: regulation of antigen processing and presentation of peptide antigen via MHC class I
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I.
has exact synonym: downregulation of antigen processing and presentation of peptide antigen via MHC class I
has exact synonym: down regulation of antigen processing and presentation of peptide antigen via MHC class I
has exact synonym: down-regulation of antigen processing and presentation of peptide antigen via MHC class I
has related synonym: inhibition of antigen processing and presentation of peptide antigen via MHC class I
has exact synonym: negative regulation of peptide antigen processing and presentation via MHC class I

positive regulation of antigen processing and presentation of peptide antigen via MHC class I
type: Class
subclass of: positive regulation of antigen processing and presentation of peptide antigen
subclass of: regulation of antigen processing and presentation of peptide antigen via MHC class I
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I.
has related synonym: activation of antigen processing and presentation of peptide antigen via MHC class I
has exact synonym: positive regulation of peptide antigen processing and presentation via MHC class I
has related synonym: stimulation of antigen processing and presentation of peptide antigen via MHC class I
has exact synonym: upregulation of antigen processing and presentation of peptide antigen via MHC class I
has exact synonym: up regulation of antigen processing and presentation of peptide antigen via MHC class I
has exact synonym: up-regulation of antigen processing and presentation of peptide antigen via MHC class I

regulation of antigen processing and presentation via MHC class Ib
type: Class
subclass of: regulation of antigen processing and presentation
IAO_0000115: Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib.

negative regulation of antigen processing and presentation via MHC class Ib
type: Class
subclass of: negative regulation of antigen processing and presentation
subclass of: regulation of antigen processing and presentation via MHC class Ib
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib.
has exact synonym: downregulation of antigen processing and presentation via MHC class Ib
has exact synonym: down regulation of antigen processing and presentation via MHC class Ib
has exact synonym: down-regulation of antigen processing and presentation via MHC class Ib
has related synonym: inhibition of antigen processing and presentation via MHC class Ib

positive regulation of antigen processing and presentation via MHC class Ib
type: Class
subclass of: positive regulation of antigen processing and presentation
subclass of: regulation of antigen processing and presentation via MHC class Ib
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib.
has related synonym: activation of antigen processing and presentation via MHC class Ib
has related synonym: stimulation of antigen processing and presentation via MHC class Ib
has exact synonym: upregulation of antigen processing and presentation via MHC class Ib
has exact synonym: up regulation of antigen processing and presentation via MHC class Ib
has exact synonym: up-regulation of antigen processing and presentation via MHC class Ib

regulation of antigen processing and presentation of peptide antigen via MHC class Ib
type: Class
subclass of: regulation of antigen processing and presentation of peptide antigen
subclass of: regulation of antigen processing and presentation via MHC class Ib
IAO_0000115: Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib.
has exact synonym: regulation of peptide antigen processing and presentation via MHC class Ib

negative regulation of antigen processing and presentation of peptide antigen via MHC class Ib
type: Class
subclass of: negative regulation of antigen processing and presentation of peptide antigen
subclass of: negative regulation of antigen processing and presentation via MHC class Ib
subclass of: regulation of antigen processing and presentation of peptide antigen via MHC class Ib
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib.
has exact synonym: downregulation of antigen processing and presentation of peptide antigen via MHC class Ib
has exact synonym: down regulation of antigen processing and presentation of peptide antigen via MHC class Ib
has exact synonym: down-regulation of antigen processing and presentation of peptide antigen via MHC class Ib
has related synonym: inhibition of antigen processing and presentation of peptide antigen via MHC class Ib
has exact synonym: negative regulation of peptide antigen processing and presentation via MHC class Ib

positive regulation of antigen processing and presentation of peptide antigen via MHC class Ib
type: Class
subclass of: positive regulation of antigen processing and presentation of peptide antigen
subclass of: positive regulation of antigen processing and presentation via MHC class Ib
subclass of: regulation of antigen processing and presentation of peptide antigen via MHC class Ib
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib.
has related synonym: activation of antigen processing and presentation of peptide antigen via MHC class Ib
has exact synonym: positive regulation of peptide antigen processing and presentation via MHC class Ib
has related synonym: stimulation of antigen processing and presentation of peptide antigen via MHC class Ib
has exact synonym: upregulation of antigen processing and presentation of peptide antigen via MHC class Ib
has exact synonym: up regulation of antigen processing and presentation of peptide antigen via MHC class Ib
has exact synonym: up-regulation of antigen processing and presentation of peptide antigen via MHC class Ib

regulation of antigen processing and presentation of lipid antigen via MHC class Ib
type: Class
subclass of: regulation of antigen processing and presentation via MHC class Ib
IAO_0000115: Any process that modulates the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib.
has exact synonym: regulation of lipid antigen processing and presentation via MHC class Ib

negative regulation of antigen processing and presentation of lipid antigen via MHC class Ib
type: Class
subclass of: negative regulation of antigen processing and presentation via MHC class Ib
subclass of: regulation of antigen processing and presentation of lipid antigen via MHC class Ib
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib.
has exact synonym: downregulation of antigen processing and presentation of lipid antigen via MHC class Ib
has exact synonym: down regulation of antigen processing and presentation of lipid antigen via MHC class Ib
has exact synonym: down-regulation of antigen processing and presentation of lipid antigen via MHC class Ib
has related synonym: inhibition of antigen processing and presentation of lipid antigen via MHC class Ib
has exact synonym: negative regulation of lipid antigen processing and presentation via MHC class Ib

positive regulation of antigen processing and presentation of lipid antigen via MHC class Ib
type: Class
subclass of: positive regulation of antigen processing and presentation via MHC class Ib
subclass of: regulation of antigen processing and presentation of lipid antigen via MHC class Ib
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib.
has related synonym: activation of antigen processing and presentation of lipid antigen via MHC class Ib
has exact synonym: positive regulation of lipid antigen processing and presentation via MHC class Ib
has related synonym: stimulation of antigen processing and presentation of lipid antigen via MHC class Ib
has exact synonym: upregulation of antigen processing and presentation of lipid antigen via MHC class Ib
has exact synonym: up regulation of antigen processing and presentation of lipid antigen via MHC class Ib
has exact synonym: up-regulation of antigen processing and presentation of lipid antigen via MHC class Ib

regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
type: Class
subclass of: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
IAO_0000115: Any process that modulates the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II.
has exact synonym: regulation of polysaccharide antigen processing and presentation via MHC class II

negative regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
type: Class
subclass of: negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
subclass of: regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II.
has exact synonym: downregulation of antigen processing and presentation of polysaccharide antigen via MHC class II
has exact synonym: down regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
has exact synonym: down-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
has related synonym: inhibition of antigen processing and presentation of polysaccharide antigen via MHC class II
has exact synonym: negative regulation of polysaccharide antigen processing and presentation via MHC class II

positive regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
type: Class
subclass of: positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
subclass of: regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II.
has related synonym: activation of antigen processing and presentation of polysaccharide antigen via MHC class II
has exact synonym: positive regulation of polysaccharide antigen processing and presentation via MHC class II
has related synonym: stimulation of antigen processing and presentation of polysaccharide antigen via MHC class II
has exact synonym: upregulation of antigen processing and presentation of polysaccharide antigen via MHC class II
has exact synonym: up regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
has exact synonym: up-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II

regulation of dendritic cell antigen processing and presentation
type: Class
subclass of: regulation of antigen processing and presentation
IAO_0000115: Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation.

negative regulation of dendritic cell antigen processing and presentation
type: Class
subclass of: negative regulation of antigen processing and presentation
subclass of: regulation of dendritic cell antigen processing and presentation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation.
has exact synonym: downregulation of dendritic cell antigen processing and presentation
has exact synonym: down regulation of dendritic cell antigen processing and presentation
has exact synonym: down-regulation of dendritic cell antigen processing and presentation
has related synonym: inhibition of dendritic cell antigen processing and presentation

positive regulation of dendritic cell antigen processing and presentation
type: Class
subclass of: positive regulation of antigen processing and presentation
subclass of: regulation of dendritic cell antigen processing and presentation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation.
has related synonym: activation of dendritic cell antigen processing and presentation
has related synonym: stimulation of dendritic cell antigen processing and presentation
has exact synonym: upregulation of dendritic cell antigen processing and presentation
has exact synonym: up regulation of dendritic cell antigen processing and presentation
has exact synonym: up-regulation of dendritic cell antigen processing and presentation

regulation of myeloid dendritic cell antigen processing and presentation
type: Class
subclass of: regulation of dendritic cell antigen processing and presentation
IAO_0000115: Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation.

negative regulation of myeloid dendritic cell antigen processing and presentation
type: Class
subclass of: negative regulation of dendritic cell antigen processing and presentation
subclass of: regulation of myeloid dendritic cell antigen processing and presentation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation.
has exact synonym: downregulation of myeloid dendritic cell antigen processing and presentation
has exact synonym: down regulation of myeloid dendritic cell antigen processing and presentation
has exact synonym: down-regulation of myeloid dendritic cell antigen processing and presentation
has related synonym: inhibition of myeloid dendritic cell antigen processing and presentation

positive regulation of myeloid dendritic cell antigen processing and presentation
type: Class
subclass of: positive regulation of dendritic cell antigen processing and presentation
subclass of: regulation of myeloid dendritic cell antigen processing and presentation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation.
has related synonym: activation of myeloid dendritic cell antigen processing and presentation
has related synonym: stimulation of myeloid dendritic cell antigen processing and presentation
has exact synonym: upregulation of myeloid dendritic cell antigen processing and presentation
has exact synonym: up regulation of myeloid dendritic cell antigen processing and presentation
has exact synonym: up-regulation of myeloid dendritic cell antigen processing and presentation

regulation of plasmacytoid dendritic cell antigen processing and presentation
type: Class
subclass of: regulation of dendritic cell antigen processing and presentation
IAO_0000115: Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation.

negative regulation of plasmacytoid dendritic cell antigen processing and presentation
type: Class
subclass of: negative regulation of dendritic cell antigen processing and presentation
subclass of: regulation of plasmacytoid dendritic cell antigen processing and presentation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation.
has exact synonym: downregulation of plasmacytoid dendritic cell antigen processing and presentation
has exact synonym: down regulation of plasmacytoid dendritic cell antigen processing and presentation
has exact synonym: down-regulation of plasmacytoid dendritic cell antigen processing and presentation
has related synonym: inhibition of plasmacytoid dendritic cell antigen processing and presentation

positive regulation of plasmacytoid dendritic cell antigen processing and presentation
type: Class
subclass of: positive regulation of dendritic cell antigen processing and presentation
subclass of: regulation of plasmacytoid dendritic cell antigen processing and presentation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation.
has related synonym: activation of plasmacytoid dendritic cell antigen processing and presentation
has related synonym: stimulation of plasmacytoid dendritic cell antigen processing and presentation
has exact synonym: upregulation of plasmacytoid dendritic cell antigen processing and presentation
has exact synonym: up regulation of plasmacytoid dendritic cell antigen processing and presentation
has exact synonym: up-regulation of plasmacytoid dendritic cell antigen processing and presentation

regulation of monocyte antigen processing and presentation
type: Class
subclass of: regulation of antigen processing and presentation
IAO_0000115: Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation.

negative regulation of monocyte antigen processing and presentation
type: Class
subclass of: negative regulation of antigen processing and presentation
subclass of: regulation of monocyte antigen processing and presentation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation.
has exact synonym: downregulation of monocyte antigen processing and presentation
has exact synonym: down regulation of monocyte antigen processing and presentation
has exact synonym: down-regulation of monocyte antigen processing and presentation
has related synonym: inhibition of monocyte antigen processing and presentation

positive regulation of monocyte antigen processing and presentation
type: Class
subclass of: positive regulation of antigen processing and presentation
subclass of: regulation of monocyte antigen processing and presentation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation.
has related synonym: activation of monocyte antigen processing and presentation
has related synonym: stimulation of monocyte antigen processing and presentation
has exact synonym: upregulation of monocyte antigen processing and presentation
has exact synonym: up regulation of monocyte antigen processing and presentation
has exact synonym: up-regulation of monocyte antigen processing and presentation

regulation of macrophage antigen processing and presentation
type: Class
subclass of: regulation of antigen processing and presentation
IAO_0000115: Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation.

negative regulation of macrophage antigen processing and presentation
type: Class
subclass of: negative regulation of antigen processing and presentation
subclass of: regulation of macrophage antigen processing and presentation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation.
has exact synonym: downregulation of macrophage antigen processing and presentation
has exact synonym: down regulation of macrophage antigen processing and presentation
has exact synonym: down-regulation of macrophage antigen processing and presentation
has related synonym: inhibition of macrophage antigen processing and presentation

positive regulation of macrophage antigen processing and presentation
type: Class
subclass of: positive regulation of antigen processing and presentation
subclass of: regulation of macrophage antigen processing and presentation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation.
has related synonym: activation of macrophage antigen processing and presentation
has related synonym: stimulation of macrophage antigen processing and presentation
has exact synonym: upregulation of macrophage antigen processing and presentation
has exact synonym: up regulation of macrophage antigen processing and presentation
has exact synonym: up-regulation of macrophage antigen processing and presentation

regulation of non-professional antigen presenting cell antigen processing and presentation
type: Class
subclass of: regulation of antigen processing and presentation
IAO_0000115: Any process that modulates the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation.

negative regulation of non-professional antigen presenting cell antigen processing and presentation
type: Class
subclass of: negative regulation of antigen processing and presentation
subclass of: regulation of non-professional antigen presenting cell antigen processing and presentation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation.
has exact synonym: downregulation of non-professional antigen presenting cell antigen processing and presentation
has exact synonym: down regulation of non-professional antigen presenting cell antigen processing and presentation
has exact synonym: down-regulation of non-professional antigen presenting cell antigen processing and presentation
has related synonym: inhibition of non-professional antigen presenting cell antigen processing and presentation

positive regulation of non-professional antigen presenting cell antigen processing and presentation
type: Class
subclass of: positive regulation of antigen processing and presentation
subclass of: regulation of non-professional antigen presenting cell antigen processing and presentation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation.
has related synonym: activation of non-professional antigen presenting cell antigen processing and presentation
has related synonym: stimulation of non-professional antigen presenting cell antigen processing and presentation
has exact synonym: upregulation of non-professional antigen presenting cell antigen processing and presentation
has exact synonym: up regulation of non-professional antigen presenting cell antigen processing and presentation
has exact synonym: up-regulation of non-professional antigen presenting cell antigen processing and presentation

regulation of B cell antigen processing and presentation
type: Class
subclass of: regulation of antigen processing and presentation
subclass of: regulation of B cell mediated immunity
IAO_0000115: Any process that modulates the frequency, rate, or extent of B cell antigen processing and presentation.
has exact synonym: regulation of B-cell antigen processing and presentation
has exact synonym: regulation of B lymphocyte antigen processing and presentation
has exact synonym: regulation of B-lymphocyte antigen processing and presentation

negative regulation of B cell antigen processing and presentation
type: Class
subclass of: negative regulation of antigen processing and presentation
subclass of: regulation of B cell antigen processing and presentation
subclass of: negative regulation of B cell mediated immunity
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell antigen processing and presentation.
has exact synonym: downregulation of B cell antigen processing and presentation
has exact synonym: down regulation of B cell antigen processing and presentation
has exact synonym: down-regulation of B cell antigen processing and presentation
has related synonym: inhibition of B cell antigen processing and presentation
has exact synonym: negative regulation of B-cell antigen processing and presentation
has exact synonym: negative regulation of B lymphocyte antigen processing and presentation
has exact synonym: negative regulation of B-lymphocyte antigen processing and presentation

positive regulation of B cell antigen processing and presentation
type: Class
subclass of: positive regulation of antigen processing and presentation
subclass of: regulation of B cell antigen processing and presentation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of B cell antigen processing and presentation.
has related synonym: activation of B cell antigen processing and presentation
has exact synonym: positive regulation of B-cell antigen processing and presentation
has exact synonym: positive regulation of B lymphocyte antigen processing and presentation
has exact synonym: positive regulation of B-lymphocyte antigen processing and presentation
has related synonym: stimulation of B cell antigen processing and presentation
has exact synonym: upregulation of B cell antigen processing and presentation
has exact synonym: up regulation of B cell antigen processing and presentation
has exact synonym: up-regulation of B cell antigen processing and presentation

regulation of T cell antigen processing and presentation
type: Class
subclass of: regulation of antigen processing and presentation
subclass of: regulation of T cell mediated immunity
IAO_0000115: Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation.
has exact synonym: regulation of T-cell antigen processing and presentation
has exact synonym: regulation of T lymphocyte antigen processing and presentation
has exact synonym: regulation of T-lymphocyte antigen processing and presentation

negative regulation of T cell antigen processing and presentation
type: Class
subclass of: negative regulation of antigen processing and presentation
subclass of: regulation of T cell antigen processing and presentation
subclass of: negative regulation of T cell mediated immunity
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation.
has exact synonym: downregulation of T cell antigen processing and presentation
has exact synonym: down regulation of T cell antigen processing and presentation
has exact synonym: down-regulation of T cell antigen processing and presentation
has related synonym: inhibition of T cell antigen processing and presentation
has exact synonym: negative regulation of T-cell antigen processing and presentation
has exact synonym: negative regulation of T lymphocyte antigen processing and presentation
has exact synonym: negative regulation of T-lymphocyte antigen processing and presentation

positive regulation of T cell antigen processing and presentation
type: Class
subclass of: positive regulation of antigen processing and presentation
subclass of: regulation of T cell antigen processing and presentation
subclass of: positive regulation of T cell mediated immunity
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation.
has related synonym: activation of T cell antigen processing and presentation
has exact synonym: positive regulation of T-cell antigen processing and presentation
has exact synonym: positive regulation of T lymphocyte antigen processing and presentation
has exact synonym: positive regulation of T-lymphocyte antigen processing and presentation
has related synonym: stimulation of T cell antigen processing and presentation
has exact synonym: upregulation of T cell antigen processing and presentation
has exact synonym: up regulation of T cell antigen processing and presentation
has exact synonym: up-regulation of T cell antigen processing and presentation

regulation of proteolysis associated with antigen processing and presentation
type: Class
subclass of: GO_1903050
IAO_0000115: Any process that modulates the frequency, rate, or extent of proteolysis associated with antigen processing and presentation.

negative regulation of proteolysis associated with antigen processing and presentation
type: Class
subclass of: negative regulation of antigen processing and presentation of peptide antigen
subclass of: regulation of proteolysis associated with antigen processing and presentation
subclass of: GO_0031330
subclass of: GO_0042177
subclass of: GO_1903051
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of proteolysis associated with antigen processing and presentation.
has exact synonym: downregulation of proteolysis associated with antigen processing and presentation
has exact synonym: down regulation of proteolysis associated with antigen processing and presentation
has exact synonym: down-regulation of proteolysis associated with antigen processing and presentation
has related synonym: inhibition of proteolysis associated with antigen processing and presentation

positive regulation of proteolysis associated with antigen processing and presentation
type: Class
subclass of: positive regulation of antigen processing and presentation of peptide antigen
subclass of: regulation of proteolysis associated with antigen processing and presentation
subclass of: GO_0031331
subclass of: GO_0045732
subclass of: GO_1903052
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of proteolysis associated with antigen processing and presentation.
has related synonym: activation of proteolysis associated with antigen processing and presentation
has related synonym: stimulation of proteolysis associated with antigen processing and presentation
has exact synonym: upregulation of proteolysis associated with antigen processing and presentation
has exact synonym: up regulation of proteolysis associated with antigen processing and presentation
has exact synonym: up-regulation of proteolysis associated with antigen processing and presentation

regulation of granuloma formation
type: Class
subclass of: regulation of chronic inflammatory response
subclass of: regulation of immune effector process
IAO_0000115: Any process that modulates the frequency, rate, or extent of granuloma formation.

negative regulation of granuloma formation
type: Class
subclass of: regulation of granuloma formation
subclass of: negative regulation of chronic inflammatory response
subclass of: negative regulation of immune effector process
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of granuloma formation.
has exact synonym: downregulation of granuloma formation
has exact synonym: down regulation of granuloma formation
has exact synonym: down-regulation of granuloma formation
has related synonym: inhibition of granuloma formation

positive regulation of granuloma formation
type: Class
subclass of: regulation of granuloma formation
subclass of: positive regulation of chronic inflammatory response
subclass of: positive regulation of immune effector process
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of granuloma formation.
has related synonym: activation of granuloma formation
has related synonym: stimulation of granuloma formation
has exact synonym: upregulation of granuloma formation
has exact synonym: up regulation of granuloma formation
has exact synonym: up-regulation of granuloma formation

regulation of germinal center formation
type: Class
subclass of: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: GO_0022603
IAO_0000115: Any process that modulates the frequency, rate, or extent of germinal center formation.

negative regulation of germinal center formation
type: Class
subclass of: regulation of germinal center formation
subclass of: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: GO_0051093
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of germinal center formation.
has exact synonym: downregulation of germinal center formation
has exact synonym: down regulation of germinal center formation
has exact synonym: down-regulation of germinal center formation
has related synonym: inhibition of germinal center formation

positive regulation of germinal center formation
type: Class
subclass of: regulation of germinal center formation
subclass of: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: GO_0051094
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of germinal center formation.
has related synonym: activation of germinal center formation
has related synonym: stimulation of germinal center formation
has exact synonym: upregulation of germinal center formation
has exact synonym: up regulation of germinal center formation
has exact synonym: up-regulation of germinal center formation

regulation of immunoglobulin production
type: Class
subclass of: regulation of production of molecular mediator of immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of immunoglobulin production.
has exact synonym: regulation of antibody production
has related synonym: regulation of immunoglobulin biosynthetic process
has related synonym: regulation of immunoglobulin secretion
replaces: GO_0002640
replaces: GO_0051023

negative regulation of immunoglobulin production
type: Class
subclass of: regulation of immunoglobulin production
subclass of: negative regulation of production of molecular mediator of immune response
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production.
has exact synonym: downregulation of immunoglobulin production
has exact synonym: down regulation of immunoglobulin production
has exact synonym: down-regulation of immunoglobulin production
has related synonym: inhibition of immunoglobulin production
has related synonym: negative regulation of immunoglobulin biosynthetic process
has related synonym: negative regulation of immunoglobulin secretion
replaces: GO_0002641
replaces: GO_0051025

positive regulation of immunoglobulin production
type: Class
subclass of: regulation of immunoglobulin production
subclass of: positive regulation of production of molecular mediator of immune response
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of immunoglobulin production.
has related synonym: activation of immunoglobulin production
has related synonym: positive regulation of immunoglobulin biosynthetic process
has related synonym: positive regulation of immunoglobulin secretion
has related synonym: stimulation of immunoglobulin production
has exact synonym: upregulation of immunoglobulin production
has exact synonym: up regulation of immunoglobulin production
has exact synonym: up-regulation of immunoglobulin production
replaces: GO_0002642
replaces: GO_0051024

regulation of tolerance induction
type: Class
subclass of: regulation of immune system process
IAO_0000115: Any process that modulates the frequency, rate, or extent of tolerance induction.

negative regulation of tolerance induction
type: Class
subclass of: regulation of tolerance induction
subclass of: negative regulation of immune system process
subclass of: GO_0051093
subclass of: GO_0051241
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction.
has exact synonym: downregulation of tolerance induction
has exact synonym: down regulation of tolerance induction
has exact synonym: down-regulation of tolerance induction
has related synonym: inhibition of tolerance induction

positive regulation of tolerance induction
type: Class
subclass of: regulation of tolerance induction
subclass of: positive regulation of immune system process
subclass of: GO_0051240
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of tolerance induction.
has related synonym: activation of tolerance induction
has related synonym: stimulation of tolerance induction
has exact synonym: upregulation of tolerance induction
has exact synonym: up regulation of tolerance induction
has exact synonym: up-regulation of tolerance induction

regulation of central tolerance induction
type: Class
subclass of: regulation of tolerance induction
IAO_0000115: Any process that modulates the frequency, rate, or extent of central tolerance induction.

negative regulation of central tolerance induction
type: Class
subclass of: negative regulation of tolerance induction
subclass of: regulation of central tolerance induction
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of central tolerance induction.
has exact synonym: downregulation of central tolerance induction
has exact synonym: down regulation of central tolerance induction
has exact synonym: down-regulation of central tolerance induction
has related synonym: inhibition of central tolerance induction

positive regulation of central tolerance induction
type: Class
subclass of: positive regulation of tolerance induction
subclass of: regulation of central tolerance induction
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of central tolerance induction.
has related synonym: activation of central tolerance induction
has related synonym: stimulation of central tolerance induction
has exact synonym: upregulation of central tolerance induction
has exact synonym: up regulation of central tolerance induction
has exact synonym: up-regulation of central tolerance induction

regulation of tolerance induction to self antigen
type: Class
subclass of: regulation of tolerance induction
IAO_0000115: Any process that modulates the frequency, rate, or extent of tolerance induction to self antigen.

negative regulation of tolerance induction to self antigen
type: Class
subclass of: negative regulation of tolerance induction
subclass of: regulation of tolerance induction to self antigen
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to self antigen.
has exact synonym: downregulation of tolerance induction to self antigen
has exact synonym: down regulation of tolerance induction to self antigen
has exact synonym: down-regulation of tolerance induction to self antigen
has related synonym: inhibition of tolerance induction to self antigen

positive regulation of tolerance induction to self antigen
type: Class
subclass of: positive regulation of tolerance induction
subclass of: regulation of tolerance induction to self antigen
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of tolerance induction to self antigen.
has related synonym: activation of tolerance induction to self antigen
has related synonym: stimulation of tolerance induction to self antigen
has exact synonym: upregulation of tolerance induction to self antigen
has exact synonym: up regulation of tolerance induction to self antigen
has exact synonym: up-regulation of tolerance induction to self antigen

regulation of tolerance induction dependent upon immune response
type: Class
subclass of: regulation of tolerance induction
subclass of: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
IAO_0000115: Any process that modulates the frequency, rate, or extent of tolerance induction dependent upon immune response.
has exact synonym: regulation of immune response-dependent tolerance induction

negative regulation of tolerance induction dependent upon immune response
type: Class
subclass of: negative regulation of tolerance induction
subclass of: regulation of tolerance induction dependent upon immune response
subclass of: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction dependent upon immune response.
has exact synonym: downregulation of tolerance induction dependent upon immune response
has exact synonym: down regulation of tolerance induction dependent upon immune response
has exact synonym: down-regulation of tolerance induction dependent upon immune response
has related synonym: inhibition of tolerance induction dependent upon immune response
has exact synonym: negative regulation of immune response-dependent tolerance induction

positive regulation of tolerance induction dependent upon immune response
type: Class
subclass of: positive regulation of tolerance induction
subclass of: regulation of tolerance induction dependent upon immune response
subclass of: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of tolerance induction dependent upon immune response.
has related synonym: activation of tolerance induction dependent upon immune response
has exact synonym: positive regulation of immune response-dependent tolerance induction
has related synonym: stimulation of tolerance induction dependent upon immune response
has exact synonym: upregulation of tolerance induction dependent upon immune response
has exact synonym: up regulation of tolerance induction dependent upon immune response
has exact synonym: up-regulation of tolerance induction dependent upon immune response

regulation of tolerance induction to nonself antigen
type: Class
subclass of: regulation of tolerance induction dependent upon immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of tolerance induction to nonself antigen.

negative regulation of tolerance induction to nonself antigen
type: Class
subclass of: negative regulation of tolerance induction dependent upon immune response
subclass of: regulation of tolerance induction to nonself antigen
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to nonself antigen.
has exact synonym: downregulation of tolerance induction to nonself antigen
has exact synonym: down regulation of tolerance induction to nonself antigen
has exact synonym: down-regulation of tolerance induction to nonself antigen
has related synonym: inhibition of tolerance induction to nonself antigen

positive regulation of tolerance induction to nonself antigen
type: Class
subclass of: positive regulation of tolerance induction dependent upon immune response
subclass of: regulation of tolerance induction to nonself antigen
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of tolerance induction to nonself antigen.
has related synonym: activation of tolerance induction to nonself antigen
has related synonym: stimulation of tolerance induction to nonself antigen
has exact synonym: upregulation of tolerance induction to nonself antigen
has exact synonym: up regulation of tolerance induction to nonself antigen
has exact synonym: up-regulation of tolerance induction to nonself antigen

regulation of peripheral tolerance induction
type: Class
subclass of: regulation of tolerance induction dependent upon immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of peripheral tolerance induction.

negative regulation of peripheral tolerance induction
type: Class
subclass of: negative regulation of tolerance induction dependent upon immune response
subclass of: regulation of peripheral tolerance induction
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral tolerance induction.
has exact synonym: downregulation of peripheral tolerance induction
has exact synonym: down regulation of peripheral tolerance induction
has exact synonym: down-regulation of peripheral tolerance induction
has related synonym: inhibition of peripheral tolerance induction

positive regulation of peripheral tolerance induction
type: Class
subclass of: positive regulation of tolerance induction dependent upon immune response
subclass of: regulation of peripheral tolerance induction
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of peripheral tolerance induction.
has related synonym: activation of peripheral tolerance induction
has related synonym: stimulation of peripheral tolerance induction
has exact synonym: upregulation of peripheral tolerance induction
has exact synonym: up regulation of peripheral tolerance induction
has exact synonym: up-regulation of peripheral tolerance induction

regulation of B cell tolerance induction
type: Class
subclass of: regulation of tolerance induction
IAO_0000115: Any process that modulates the frequency, rate, or extent of B cell tolerance induction.
has exact synonym: regulation of B-cell tolerance induction
has exact synonym: regulation of B lymphocyte tolerance induction
has exact synonym: regulation of B-lymphocyte tolerance induction

negative regulation of B cell tolerance induction
type: Class
subclass of: negative regulation of tolerance induction
subclass of: regulation of B cell tolerance induction
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell tolerance induction.
has exact synonym: downregulation of B cell tolerance induction
has exact synonym: down regulation of B cell tolerance induction
has exact synonym: down-regulation of B cell tolerance induction
has related synonym: inhibition of B cell tolerance induction
has exact synonym: negative regulation of B-cell tolerance induction
has exact synonym: negative regulation of B lymphocyte tolerance induction
has exact synonym: negative regulation of B-lymphocyte tolerance induction

positive regulation of B cell tolerance induction
type: Class
subclass of: positive regulation of tolerance induction
subclass of: regulation of B cell tolerance induction
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of B cell tolerance induction.
has related synonym: activation of B cell tolerance induction
has exact synonym: positive regulation of B-cell tolerance induction
has exact synonym: positive regulation of B lymphocyte tolerance induction
has exact synonym: positive regulation of B-lymphocyte tolerance induction
has related synonym: stimulation of B cell tolerance induction
has exact synonym: upregulation of B cell tolerance induction
has exact synonym: up regulation of B cell tolerance induction
has exact synonym: up-regulation of B cell tolerance induction

regulation of T cell tolerance induction
type: Class
subclass of: regulation of tolerance induction
IAO_0000115: Any process that modulates the frequency, rate, or extent of T cell tolerance induction.
has exact synonym: regulation of T-cell tolerance induction
has exact synonym: regulation of T lymphocyte tolerance induction
has exact synonym: regulation of T-lymphocyte tolerance induction

negative regulation of T cell tolerance induction
type: Class
subclass of: negative regulation of tolerance induction
subclass of: regulation of T cell tolerance induction
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction.
has exact synonym: downregulation of T cell tolerance induction
has exact synonym: down regulation of T cell tolerance induction
has exact synonym: down-regulation of T cell tolerance induction
has related synonym: inhibition of T cell tolerance induction
has exact synonym: negative regulation of T-cell tolerance induction
has exact synonym: negative regulation of T lymphocyte tolerance induction
has exact synonym: negative regulation of T-lymphocyte tolerance induction

positive regulation of T cell tolerance induction
type: Class
subclass of: positive regulation of tolerance induction
subclass of: regulation of T cell tolerance induction
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction.
has related synonym: activation of T cell tolerance induction
has exact synonym: positive regulation of T-cell tolerance induction
has exact synonym: positive regulation of T lymphocyte tolerance induction
has exact synonym: positive regulation of T-lymphocyte tolerance induction
has related synonym: stimulation of T cell tolerance induction
has exact synonym: upregulation of T cell tolerance induction
has exact synonym: up regulation of T cell tolerance induction
has exact synonym: up-regulation of T cell tolerance induction

regulation of T cell anergy
type: Class
subclass of: regulation of T cell tolerance induction
subclass of: regulation of lymphocyte anergy
IAO_0000115: Any process that modulates the frequency, rate, or extent of T cell anergy.
has exact synonym: regulation of T-cell anergy
has exact synonym: regulation of T lymphocyte anergy
has exact synonym: regulation of T-lymphocyte anergy

negative regulation of T cell anergy
type: Class
subclass of: negative regulation of T cell tolerance induction
subclass of: regulation of T cell anergy
subclass of: negative regulation of lymphocyte anergy
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell anergy.
has exact synonym: downregulation of T cell anergy
has exact synonym: down regulation of T cell anergy
has exact synonym: down-regulation of T cell anergy
has related synonym: inhibition of T cell anergy
has exact synonym: negative regulation of T-cell anergy
has exact synonym: negative regulation of T lymphocyte anergy
has exact synonym: negative regulation of T-lymphocyte anergy

positive regulation of T cell anergy
type: Class
subclass of: positive regulation of T cell tolerance induction
subclass of: regulation of T cell anergy
subclass of: positive regulation of lymphocyte anergy
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of T cell anergy.
has related synonym: activation of T cell anergy
has exact synonym: positive regulation of T-cell anergy
has exact synonym: positive regulation of T lymphocyte anergy
has exact synonym: positive regulation of T-lymphocyte anergy
has related synonym: stimulation of T cell anergy
has exact synonym: upregulation of T cell anergy
has exact synonym: up regulation of T cell anergy
has exact synonym: up-regulation of T cell anergy

regulation of B cell anergy
type: Class
subclass of: regulation of B cell tolerance induction
subclass of: regulation of lymphocyte anergy
IAO_0000115: Any process that modulates the frequency, rate, or extent of B cell anergy.
has exact synonym: regulation of B-cell anergy
has exact synonym: regulation of B lymphocyte anergy
has exact synonym: regulation of B-lymphocyte anergy

negative regulation of B cell anergy
type: Class
subclass of: negative regulation of B cell tolerance induction
subclass of: regulation of B cell anergy
subclass of: negative regulation of lymphocyte anergy
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell anergy.
has exact synonym: downregulation of B cell anergy
has exact synonym: down regulation of B cell anergy
has exact synonym: down-regulation of B cell anergy
has related synonym: inhibition of B cell anergy
has exact synonym: negative regulation of B-cell anergy
has exact synonym: negative regulation of B lymphocyte anergy
has exact synonym: negative regulation of B-lymphocyte anergy

positive regulation of B cell anergy
type: Class
subclass of: positive regulation of B cell tolerance induction
subclass of: regulation of B cell anergy
subclass of: positive regulation of lymphocyte anergy
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of B cell anergy.
has related synonym: activation of B cell anergy
has exact synonym: positive regulation of B-cell anergy
has exact synonym: positive regulation of B lymphocyte anergy
has exact synonym: positive regulation of B-lymphocyte anergy
has related synonym: stimulation of B cell anergy
has exact synonym: upregulation of B cell anergy
has exact synonym: up regulation of B cell anergy
has exact synonym: up-regulation of B cell anergy

regulation of acute inflammatory response
type: Class
subclass of: GO_0050727
IAO_0000115: Any process that modulates the frequency, rate, or extent of an acute inflammatory response.

negative regulation of acute inflammatory response
type: Class
subclass of: regulation of acute inflammatory response
subclass of: GO_0050728
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response.
has exact synonym: downregulation of acute inflammatory response
has exact synonym: down regulation of acute inflammatory response
has exact synonym: down-regulation of acute inflammatory response
has related synonym: inhibition of acute inflammatory response

positive regulation of acute inflammatory response
type: Class
subclass of: regulation of acute inflammatory response
subclass of: GO_0050729
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response.
has related synonym: activation of acute inflammatory response
has related synonym: stimulation of acute inflammatory response
has exact synonym: upregulation of acute inflammatory response
has exact synonym: up regulation of acute inflammatory response
has exact synonym: up-regulation of acute inflammatory response

regulation of chronic inflammatory response
type: Class
subclass of: GO_0050727
IAO_0000115: Any process that modulates the frequency, rate, or extent of a chronic inflammatory response.

negative regulation of chronic inflammatory response
type: Class
subclass of: regulation of chronic inflammatory response
subclass of: GO_0050728
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response.
has exact synonym: downregulation of chronic inflammatory response
has exact synonym: down regulation of chronic inflammatory response
has exact synonym: down-regulation of chronic inflammatory response
has related synonym: inhibition of chronic inflammatory response

positive regulation of chronic inflammatory response
type: Class
subclass of: regulation of chronic inflammatory response
subclass of: GO_0050729
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response.
has related synonym: activation of chronic inflammatory response
has related synonym: stimulation of chronic inflammatory response
has exact synonym: upregulation of chronic inflammatory response
has exact synonym: up regulation of chronic inflammatory response
has exact synonym: up-regulation of chronic inflammatory response

respiratory burst involved in defense response
type: Class
subclass of: immune effector process
subclass of: GO_0045730
subclass of: part-of-parent-6952
IAO_0000115: A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.

pro-T cell lineage commitment
type: Class
subclass of: GO_0045165
subclass of: part-of-parent-2572
IAO_0000115: The process in which a lymphoid progenitor cell becomes committed to becoming a pro-T cell.
has exact synonym: pro-T cell fate commitment
has exact synonym: pro-T lymphocyte fate commitment
has exact synonym: pro-T lymphocyte lineage commitment

somatic recombination of T cell receptor gene segments
type: Class
subclass of: somatic diversification of immune receptors via germline recombination within a single locus
subclass of: somatic diversification of T cell receptor genes
IAO_0000115: The process in which T cell receptor genes are formed through recombination of the germline genetic elements, also known as T cell receptor gene segments.
has exact synonym: somatic recombination of TCR gene segments

regulation of immune system process
type: Class
subclass of: GO_0050789
IAO_0000115: Any process that modulates the frequency, rate, or extent of an immune system process.

negative regulation of immune system process
type: Class
subclass of: regulation of immune system process
subclass of: GO_0048519
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process.
has exact synonym: downregulation of immune system process
has exact synonym: down regulation of immune system process
has exact synonym: down-regulation of immune system process
has related synonym: inhibition of immune system process

positive regulation of immune system process
type: Class
subclass of: regulation of immune system process
subclass of: GO_0048518
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an immune system process.
has related synonym: activation of immune system process
has related synonym: stimulation of immune system process
has exact synonym: upregulation of immune system process
has exact synonym: up regulation of immune system process
has exact synonym: up-regulation of immune system process

regulation of leukocyte migration
type: Class
subclass of: regulation of immune system process
subclass of: GO_0030334
IAO_0000115: Any process that modulates the frequency, rate, or extent of leukocyte migration.
has exact synonym: regulation of immune cell migration
has exact synonym: regulation of leucocyte migration

negative regulation of leukocyte migration
type: Class
subclass of: negative regulation of immune system process
subclass of: regulation of leukocyte migration
subclass of: GO_0030336
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration.
has exact synonym: downregulation of leukocyte migration
has exact synonym: down regulation of leukocyte migration
has exact synonym: down-regulation of leukocyte migration
has related synonym: inhibition of leukocyte migration
has exact synonym: negative regulation of immune cell migration
has exact synonym: negative regulation of leucocyte migration

positive regulation of leukocyte migration
type: Class
subclass of: positive regulation of immune system process
subclass of: regulation of leukocyte migration
subclass of: GO_0030335
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of leukocyte migration.
has related synonym: activation of leukocyte migration
has exact synonym: positive regulation of immune cell migration
has exact synonym: positive regulation of leucocyte migration
has related synonym: stimulation of leukocyte migration
has exact synonym: upregulation of leukocyte migration
has exact synonym: up regulation of leukocyte migration
has exact synonym: up-regulation of leukocyte migration

regulation of leukocyte chemotaxis
type: Class
subclass of: regulation of leukocyte migration
subclass of: GO_0050920
IAO_0000115: Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis.
has exact synonym: regulation of immune cell chemotaxis
has exact synonym: regulation of leucocyte chemotaxis

negative regulation of leukocyte chemotaxis
type: Class
subclass of: negative regulation of leukocyte migration
subclass of: regulation of leukocyte chemotaxis
subclass of: GO_0050922
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis.
has exact synonym: downregulation of leukocyte chemotaxis
has exact synonym: down regulation of leukocyte chemotaxis
has exact synonym: down-regulation of leukocyte chemotaxis
has related synonym: inhibition of leukocyte chemotaxis
has exact synonym: negative regulation of immune cell chemotaxis
has exact synonym: negative regulation of leucocyte chemotaxis

positive regulation of leukocyte chemotaxis
type: Class
subclass of: positive regulation of leukocyte migration
subclass of: regulation of leukocyte chemotaxis
subclass of: GO_0050921
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis.
has related synonym: activation of leukocyte chemotaxis
has exact synonym: positive regulation of immune cell chemotaxis
has exact synonym: positive regulation of leucocyte chemotaxis
has related synonym: stimulation of leukocyte chemotaxis
has exact synonym: upregulation of leukocyte chemotaxis
has exact synonym: up regulation of leukocyte chemotaxis
has exact synonym: up-regulation of leukocyte chemotaxis

regulation of cellular extravasation
type: Class
subclass of: regulation of leukocyte migration
IAO_0000115: Any process that modulates the frequency, rate, or extent of cellular extravasation.

negative regulation of cellular extravasation
type: Class
subclass of: negative regulation of leukocyte migration
subclass of: regulation of cellular extravasation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of cellular extravasation.
has exact synonym: downregulation of cellular extravasation
has exact synonym: down regulation of cellular extravasation
has exact synonym: down-regulation of cellular extravasation
has related synonym: inhibition of cellular extravasation

positive regulation of cellular extravasation
type: Class
subclass of: positive regulation of leukocyte migration
subclass of: regulation of cellular extravasation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of cellular extravasation.
has related synonym: activation of cellular extravasation
has related synonym: stimulation of cellular extravasation
has exact synonym: upregulation of cellular extravasation
has exact synonym: up regulation of cellular extravasation
has exact synonym: up-regulation of cellular extravasation

regulation of leukocyte activation
type: Class
subclass of: regulation of immune system process
subclass of: GO_0050865
IAO_0000115: Any process that modulates the frequency, rate, or extent of leukocyte activation.
has exact synonym: regulation of immune cell activation
has exact synonym: regulation of leucocyte activation

negative regulation of leukocyte activation
type: Class
subclass of: negative regulation of immune system process
subclass of: regulation of leukocyte activation
subclass of: GO_0050866
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation.
has exact synonym: downregulation of leukocyte activation
has exact synonym: down regulation of leukocyte activation
has exact synonym: down-regulation of leukocyte activation
has related synonym: inhibition of leukocyte activation
has exact synonym: negative regulation of immune cell activation
has exact synonym: negative regulation of leucocyte activation

positive regulation of leukocyte activation
type: Class
subclass of: positive regulation of immune system process
subclass of: regulation of leukocyte activation
subclass of: GO_0050867
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of leukocyte activation.
has related synonym: activation of leukocyte activation
has exact synonym: positive regulation of immune cell activation
has exact synonym: positive regulation of leucocyte activation
has related synonym: stimulation of leukocyte activation
has exact synonym: upregulation of leukocyte activation
has exact synonym: up regulation of leukocyte activation
has exact synonym: up-regulation of leukocyte activation

regulation of immune effector process
type: Class
subclass of: regulation of immune system process
IAO_0000115: Any process that modulates the frequency, rate, or extent of an immune effector process.

negative regulation of immune effector process
type: Class
subclass of: negative regulation of immune system process
subclass of: regulation of immune effector process
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process.
has exact synonym: downregulation of immune effector process
has exact synonym: down regulation of immune effector process
has exact synonym: down-regulation of immune effector process
has related synonym: inhibition of immune effector process

positive regulation of immune effector process
type: Class
subclass of: positive regulation of immune system process
subclass of: regulation of immune effector process
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an immune effector process.
has related synonym: activation of immune effector process
has related synonym: stimulation of immune effector process
has exact synonym: upregulation of immune effector process
has exact synonym: up regulation of immune effector process
has exact synonym: up-regulation of immune effector process

regulation of production of molecular mediator of immune response
type: Class
subclass of: regulation of immune effector process
subclass of: GO_0010468
IAO_0000115: Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response.

negative regulation of production of molecular mediator of immune response
type: Class
subclass of: negative regulation of immune effector process
subclass of: regulation of production of molecular mediator of immune response
subclass of: GO_0010629
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response.
has exact synonym: downregulation of production of molecular mediator of immune response
has exact synonym: down regulation of production of molecular mediator of immune response
has exact synonym: down-regulation of production of molecular mediator of immune response
has related synonym: inhibition of production of molecular mediator of immune response

positive regulation of production of molecular mediator of immune response
type: Class
subclass of: positive regulation of immune effector process
subclass of: regulation of production of molecular mediator of immune response
subclass of: GO_0010628
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response.
has related synonym: activation of production of molecular mediator of immune response
has related synonym: stimulation of production of molecular mediator of immune response
has exact synonym: upregulation of production of molecular mediator of immune response
has exact synonym: up regulation of production of molecular mediator of immune response
has exact synonym: up-regulation of production of molecular mediator of immune response

regulation of leukocyte mediated immunity
type: Class
subclass of: regulation of immune effector process
IAO_0000115: Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity.
has exact synonym: regulation of immune cell mediated immunity
has exact synonym: regulation of leucocyte mediated immunity

negative regulation of leukocyte mediated immunity
type: Class
subclass of: negative regulation of immune effector process
subclass of: regulation of leukocyte mediated immunity
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity.
has exact synonym: downregulation of leukocyte mediated immunity
has exact synonym: down regulation of leukocyte mediated immunity
has exact synonym: down-regulation of leukocyte mediated immunity
has related synonym: inhibition of leukocyte mediated immunity
has exact synonym: negative regulation of immune cell mediated immunity
has exact synonym: negative regulation of leucocyte mediated immunity

positive regulation of leukocyte mediated immunity
type: Class
subclass of: positive regulation of immune effector process
subclass of: regulation of leukocyte mediated immunity
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity.
has related synonym: activation of leukocyte mediated immunity
has exact synonym: positive regulation of immune cell mediated immunity
has exact synonym: positive regulation of leucocyte mediated immunity
has related synonym: stimulation of leukocyte mediated immunity
has exact synonym: upregulation of leukocyte mediated immunity
has exact synonym: up regulation of leukocyte mediated immunity
has exact synonym: up-regulation of leukocyte mediated immunity

regulation of lymphocyte mediated immunity
type: Class
subclass of: regulation of leukocyte mediated immunity
IAO_0000115: Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity.

negative regulation of lymphocyte mediated immunity
type: Class
subclass of: negative regulation of leukocyte mediated immunity
subclass of: regulation of lymphocyte mediated immunity
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity.
has exact synonym: downregulation of lymphocyte mediated immunity
has exact synonym: down regulation of lymphocyte mediated immunity
has exact synonym: down-regulation of lymphocyte mediated immunity
has related synonym: inhibition of lymphocyte mediated immunity

positive regulation of lymphocyte mediated immunity
type: Class
subclass of: positive regulation of leukocyte mediated immunity
subclass of: regulation of lymphocyte mediated immunity
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity.
has related synonym: activation of lymphocyte mediated immunity
has related synonym: stimulation of lymphocyte mediated immunity
has exact synonym: upregulation of lymphocyte mediated immunity
has exact synonym: up regulation of lymphocyte mediated immunity
has exact synonym: up-regulation of lymphocyte mediated immunity

regulation of T cell mediated immunity
type: Class
subclass of: regulation of lymphocyte mediated immunity
subclass of: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
IAO_0000115: Any process that modulates the frequency, rate, or extent of T cell mediated immunity.
has exact synonym: regulation of T-cell mediated immunity
has exact synonym: regulation of T lymphocyte mediated immunity
has exact synonym: regulation of T-lymphocyte mediated immunity

negative regulation of T cell mediated immunity
type: Class
subclass of: negative regulation of lymphocyte mediated immunity
subclass of: regulation of T cell mediated immunity
subclass of: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity.
has exact synonym: downregulation of T cell mediated immunity
has exact synonym: down regulation of T cell mediated immunity
has exact synonym: down-regulation of T cell mediated immunity
has related synonym: inhibition of T cell mediated immunity
has exact synonym: negative regulation of T-cell mediated immunity
has exact synonym: negative regulation of T lymphocyte mediated immunity
has exact synonym: negative regulation of T-lymphocyte mediated immunity

positive regulation of T cell mediated immunity
type: Class
subclass of: positive regulation of lymphocyte mediated immunity
subclass of: regulation of T cell mediated immunity
subclass of: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity.
has related synonym: activation of T cell mediated immunity
has exact synonym: positive regulation of T-cell mediated immunity
has exact synonym: positive regulation of T lymphocyte mediated immunity
has exact synonym: positive regulation of T-lymphocyte mediated immunity
has related synonym: stimulation of T cell mediated immunity
has exact synonym: upregulation of T cell mediated immunity
has exact synonym: up regulation of T cell mediated immunity
has exact synonym: up-regulation of T cell mediated immunity

regulation of B cell mediated immunity
type: Class
subclass of: regulation of lymphocyte mediated immunity
subclass of: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
IAO_0000115: Any process that modulates the frequency, rate, or extent of B cell mediated immunity.
has exact synonym: regulation of B-cell mediated immunity
has exact synonym: regulation of B lymphocyte mediated immunity
has exact synonym: regulation of B-lymphocyte mediated immunity

negative regulation of B cell mediated immunity
type: Class
subclass of: negative regulation of lymphocyte mediated immunity
subclass of: regulation of B cell mediated immunity
subclass of: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity.
has exact synonym: downregulation of B cell mediated immunity
has exact synonym: down regulation of B cell mediated immunity
has exact synonym: down-regulation of B cell mediated immunity
has related synonym: inhibition of B cell mediated immunity
has exact synonym: negative regulation of B-cell mediated immunity
has exact synonym: negative regulation of B lymphocyte mediated immunity
has exact synonym: negative regulation of B-lymphocyte mediated immunity

positive regulation of B cell mediated immunity
type: Class
subclass of: positive regulation of lymphocyte mediated immunity
subclass of: regulation of B cell mediated immunity
subclass of: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity.
has related synonym: activation of B cell mediated immunity
has exact synonym: positive regulation of B-cell mediated immunity
has exact synonym: positive regulation of B lymphocyte mediated immunity
has exact synonym: positive regulation of B-lymphocyte mediated immunity
has related synonym: stimulation of B cell mediated immunity
has exact synonym: upregulation of B cell mediated immunity
has exact synonym: up regulation of B cell mediated immunity
has exact synonym: up-regulation of B cell mediated immunity

regulation of natural killer cell mediated immunity
type: Class
subclass of: regulation of lymphocyte mediated immunity
subclass of: GO_0045088
IAO_0000115: Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity.
has related synonym: regulation of natural killer cell activity
has exact synonym: regulation of NK cell mediated immunity
replaces: GO_0045845

negative regulation of natural killer cell mediated immunity
type: Class
subclass of: negative regulation of lymphocyte mediated immunity
subclass of: regulation of natural killer cell mediated immunity
subclass of: GO_0045824
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity.
has exact synonym: downregulation of natural killer cell mediated immunity
has exact synonym: down regulation of natural killer cell mediated immunity
has exact synonym: down-regulation of natural killer cell mediated immunity
has related synonym: inhibition of natural killer cell mediated immunity
has related synonym: negative regulation of natural killer cell activity
has related synonym: negative regulation of NK cell activity
has exact synonym: negative regulation of NK cell mediated immunity
replaces: GO_0030102

positive regulation of natural killer cell mediated immunity
type: Class
subclass of: positive regulation of lymphocyte mediated immunity
subclass of: regulation of natural killer cell mediated immunity
subclass of: GO_0045089
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity.
has related synonym: activation of natural killer cell mediated immunity
has related synonym: positive regulation of natural killer cell activity
has related synonym: positive regulation of NK cell activity
has exact synonym: positive regulation of NK cell mediated immunity
has related synonym: stimulation of natural killer cell mediated immunity
has exact synonym: upregulation of natural killer cell mediated immunity
has exact synonym: up regulation of natural killer cell mediated immunity
has exact synonym: up-regulation of natural killer cell mediated immunity
replaces: GO_0045846

regulation of cytokine production involved in immune response
type: Class
subclass of: regulation of cytokine production
subclass of: regulation of production of molecular mediator of immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response.
has related synonym: regulation of cytokine biosynthetic process involved in immune response
has related synonym: regulation of cytokine production during immune response
has related synonym: regulation of cytokine secretion involved in immune response
replaces: GO_0002739
replaces: GO_0002742

negative regulation of cytokine production involved in immune response
type: Class
subclass of: negative regulation of cytokine production
subclass of: negative regulation of production of molecular mediator of immune response
subclass of: regulation of cytokine production involved in immune response
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response.
has related synonym: downregulation of cytokine production during immune response
has related synonym: down regulation of cytokine production during immune response
has exact synonym: down-regulation of cytokine production during immune response
has related synonym: inhibition of cytokine production during immune response
has related synonym: negative regulation of cytokine biosynthetic process involved in immune response
has related synonym: negative regulation of cytokine production during immune response
has related synonym: negative regulation of cytokine secretion involved in immune response
replaces: GO_0002740
replaces: GO_0002743

positive regulation of cytokine production involved in immune response
type: Class
subclass of: positive regulation of cytokine production
subclass of: positive regulation of production of molecular mediator of immune response
subclass of: regulation of cytokine production involved in immune response
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response.
has related synonym: activation of cytokine production during immune response
has related synonym: positive regulation of cytokine biosynthetic process involved in immune response
has related synonym: positive regulation of cytokine production during immune response
has related synonym: positive regulation of cytokine secretion involved in immune response
has related synonym: stimulation of cytokine production during immune response
has related synonym: upregulation of cytokine production during immune response
has related synonym: up regulation of cytokine production during immune response
has related synonym: up-regulation of cytokine production during immune response
replaces: GO_0002741
replaces: GO_0002744

regulation of B cell cytokine production
type: Class
subclass of: regulation of B cell mediated immunity
subclass of: regulation of cytokine production involved in immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of B cell cytokine production.
has exact synonym: regulation of B-cell cytokine production
has exact synonym: regulation of B lymphocyte cytokine production
has exact synonym: regulation of B-lymphocyte cytokine production

negative regulation of B cell cytokine production
type: Class
subclass of: negative regulation of B cell mediated immunity
subclass of: negative regulation of cytokine production involved in immune response
subclass of: regulation of B cell cytokine production
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell cytokine production.
has exact synonym: downregulation of B cell cytokine production
has exact synonym: down regulation of B cell cytokine production
has exact synonym: down-regulation of B cell cytokine production
has related synonym: inhibition of B cell cytokine production
has exact synonym: negative regulation of B-cell cytokine production
has exact synonym: negative regulation of B lymphocyte cytokine production
has exact synonym: negative regulation of B-lymphocyte cytokine production

positive regulation of B cell cytokine production
type: Class
subclass of: positive regulation of B cell mediated immunity
subclass of: positive regulation of cytokine production involved in immune response
subclass of: regulation of B cell cytokine production
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of B cell cytokine production.
has related synonym: activation of B cell cytokine production
has exact synonym: positive regulation of B-cell cytokine production
has exact synonym: positive regulation of B lymphocyte cytokine production
has exact synonym: positive regulation of B-lymphocyte cytokine production
has related synonym: stimulation of B cell cytokine production
has exact synonym: upregulation of B cell cytokine production
has exact synonym: up regulation of B cell cytokine production
has exact synonym: up-regulation of B cell cytokine production

regulation of T cell cytokine production
type: Class
subclass of: regulation of T cell mediated immunity
subclass of: regulation of cytokine production involved in immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of T cell cytokine production.
has exact synonym: regulation of T-cell cytokine production
has exact synonym: regulation of T lymphocyte cytokine production
has exact synonym: regulation of T-lymphocyte cytokine production

negative regulation of T cell cytokine production
type: Class
subclass of: negative regulation of T cell mediated immunity
subclass of: negative regulation of cytokine production involved in immune response
subclass of: regulation of T cell cytokine production
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production.
has exact synonym: downregulation of T cell cytokine production
has exact synonym: down regulation of T cell cytokine production
has exact synonym: down-regulation of T cell cytokine production
has related synonym: inhibition of T cell cytokine production
has exact synonym: negative regulation of T-cell cytokine production
has exact synonym: negative regulation of T lymphocyte cytokine production
has exact synonym: negative regulation of T-lymphocyte cytokine production

positive regulation of T cell cytokine production
type: Class
subclass of: positive regulation of T cell mediated immunity
subclass of: positive regulation of cytokine production involved in immune response
subclass of: regulation of T cell cytokine production
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of T cell cytokine production.
has related synonym: activation of T cell cytokine production
has exact synonym: positive regulation of T-cell cytokine production
has exact synonym: positive regulation of T lymphocyte cytokine production
has exact synonym: positive regulation of T-lymphocyte cytokine production
has related synonym: stimulation of T cell cytokine production
has exact synonym: upregulation of T cell cytokine production
has exact synonym: up regulation of T cell cytokine production
has exact synonym: up-regulation of T cell cytokine production

regulation of natural killer cell cytokine production
type: Class
subclass of: regulation of natural killer cell mediated immunity
subclass of: regulation of cytokine production involved in immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of natural killer cell cytokine production.
has exact synonym: regulation of NK cell cytokine production

negative regulation of natural killer cell cytokine production
type: Class
subclass of: negative regulation of natural killer cell mediated immunity
subclass of: negative regulation of cytokine production involved in immune response
subclass of: regulation of natural killer cell cytokine production
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell cytokine production.
has exact synonym: downregulation of natural killer cell cytokine production
has exact synonym: down regulation of natural killer cell cytokine production
has exact synonym: down-regulation of natural killer cell cytokine production
has related synonym: inhibition of natural killer cell cytokine production
has exact synonym: negative regulation of NK cell cytokine production

positive regulation of natural killer cell cytokine production
type: Class
subclass of: positive regulation of natural killer cell mediated immunity
subclass of: positive regulation of cytokine production involved in immune response
subclass of: regulation of natural killer cell cytokine production
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of natural killer cell cytokine production.
has related synonym: activation of natural killer cell cytokine production
has exact synonym: positive regulation of NK cell cytokine production
has related synonym: stimulation of natural killer cell cytokine production
has exact synonym: upregulation of natural killer cell cytokine production
has exact synonym: up regulation of natural killer cell cytokine production
has exact synonym: up-regulation of natural killer cell cytokine production

regulation of dendritic cell cytokine production
type: Class
subclass of: regulation of leukocyte mediated immunity
subclass of: regulation of cytokine production involved in immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production.

negative regulation of dendritic cell cytokine production
type: Class
subclass of: negative regulation of leukocyte mediated immunity
subclass of: negative regulation of cytokine production involved in immune response
subclass of: regulation of dendritic cell cytokine production
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production.
has exact synonym: downregulation of dendritic cell cytokine production
has exact synonym: down regulation of dendritic cell cytokine production
has exact synonym: down-regulation of dendritic cell cytokine production
has related synonym: inhibition of dendritic cell cytokine production

positive regulation of dendritic cell cytokine production
type: Class
subclass of: positive regulation of leukocyte mediated immunity
subclass of: positive regulation of cytokine production involved in immune response
subclass of: regulation of dendritic cell cytokine production
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production.
has related synonym: activation of dendritic cell cytokine production
has related synonym: stimulation of dendritic cell cytokine production
has exact synonym: upregulation of dendritic cell cytokine production
has exact synonym: up regulation of dendritic cell cytokine production
has exact synonym: up-regulation of dendritic cell cytokine production

regulation of myeloid dendritic cell cytokine production
type: Class
subclass of: regulation of dendritic cell cytokine production
subclass of: regulation of myeloid leukocyte mediated immunity
IAO_0000115: Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production.

negative regulation of myeloid dendritic cell cytokine production
type: Class
subclass of: negative regulation of dendritic cell cytokine production
subclass of: regulation of myeloid dendritic cell cytokine production
subclass of: negative regulation of myeloid leukocyte mediated immunity
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production.
has exact synonym: downregulation of myeloid dendritic cell cytokine production
has exact synonym: down regulation of myeloid dendritic cell cytokine production
has exact synonym: down-regulation of myeloid dendritic cell cytokine production
has related synonym: inhibition of myeloid dendritic cell cytokine production

positive regulation of myeloid dendritic cell cytokine production
type: Class
subclass of: positive regulation of dendritic cell cytokine production
subclass of: regulation of myeloid dendritic cell cytokine production
subclass of: positive regulation of myeloid leukocyte mediated immunity
subclass of: GO_0061081
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production.
has related synonym: activation of myeloid dendritic cell cytokine production
has related synonym: stimulation of myeloid dendritic cell cytokine production
has exact synonym: upregulation of myeloid dendritic cell cytokine production
has exact synonym: up regulation of myeloid dendritic cell cytokine production
has exact synonym: up-regulation of myeloid dendritic cell cytokine production

regulation of plasmacytoid dendritic cell cytokine production
type: Class
subclass of: regulation of dendritic cell cytokine production
IAO_0000115: Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production.

negative regulation of plasmacytoid dendritic cell cytokine production
type: Class
subclass of: negative regulation of dendritic cell cytokine production
subclass of: regulation of plasmacytoid dendritic cell cytokine production
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production.
has exact synonym: downregulation of plasmacytoid dendritic cell cytokine production
has exact synonym: down regulation of plasmacytoid dendritic cell cytokine production
has exact synonym: down-regulation of plasmacytoid dendritic cell cytokine production
has related synonym: inhibition of plasmacytoid dendritic cell cytokine production

positive regulation of plasmacytoid dendritic cell cytokine production
type: Class
subclass of: positive regulation of dendritic cell cytokine production
subclass of: regulation of plasmacytoid dendritic cell cytokine production
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production.
has related synonym: activation of plasmacytoid dendritic cell cytokine production
has related synonym: stimulation of plasmacytoid dendritic cell cytokine production
has exact synonym: upregulation of plasmacytoid dendritic cell cytokine production
has exact synonym: up regulation of plasmacytoid dendritic cell cytokine production
has exact synonym: up-regulation of plasmacytoid dendritic cell cytokine production

antigen processing and presentation initiated by receptor mediated uptake of antigen
type: Class
subclass of: GO_0019882
IAO_0000115: Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface receptor.

antigen processing and presentation following pinocytosis
type: Class
subclass of: GO_0019882
IAO_0000115: Antigen processing and presentation which is initiated by uptake of antigen via pinocytosis.

antigen processing and presentation following phagocytosis
type: Class
subclass of: GO_0019882
IAO_0000115: Antigen processing and presentation which is initiated by uptake of antigen via phagocytosis.

antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen
type: Class
subclass of: antigen processing and presentation initiated by receptor mediated uptake of antigen
IAO_0000115: Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface pattern recognition receptor (PRR).
has exact synonym: antigen processing and presentation initiated by PAMP receptor mediated uptake of antigen
has exact synonym: antigen processing and presentation initiated by PRR mediated uptake of antigen

antigen processing and presentation initiated by toll-like receptor mediated phagocytosis of antigen
type: Class
subclass of: antigen processing and presentation following phagocytosis
subclass of: antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen
IAO_0000115: Antigen processing and presentation which is initiated by phagocytosis of antigen bound directly or indirectly to a cell surface toll-like receptor (TLR).
has exact synonym: antigen processing and presentation initiated by TLR mediated phagocytosis of antigen

antigen processing and presentation following macropinocytosis
type: Class
subclass of: antigen processing and presentation following pinocytosis
IAO_0000115: Antigen processing and presentation which is initiated by uptake of antigen via macropinocytosis.

antigen processing and presentation following receptor mediated endocytosis
type: Class
subclass of: antigen processing and presentation initiated by receptor mediated uptake of antigen
IAO_0000115: Antigen processing and presentation which is initiated by uptake of antigen receptor-mediated endocytosis.

cell surface pattern recognition receptor signaling pathway
type: Class
subclass of: innate immune response activating cell surface receptor signaling pathway
subclass of: pattern recognition receptor signaling pathway
IAO_0000115: The series of molecular signals initiated by a ligand binding to a cell surface pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species.
has exact synonym: cell surface PAMP receptor signaling pathway
has exact synonym: cell surface pathogen receptor signaling pathway
has exact synonym: cell surface pattern recognition receptor signalling pathway
has exact synonym: cell surface PRR signaling pathway

cytoplasmic pattern recognition receptor signaling pathway
type: Class
subclass of: pattern recognition receptor signaling pathway
subclass of: GO_0030522
subclass of: GO_0035556
IAO_0000115: The series of molecular signals initiated by a ligand binding to a cytoplasmic pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species.
has exact synonym: cytoplasmic PAMP receptor signaling pathway
has exact synonym: cytoplasmic pathogen receptor signaling pathway
has exact synonym: cytoplasmic pattern recognition receptor signalling pathway
has exact synonym: cytoplasmic PRR signaling pathway

intracellular endosomal pattern recognition receptor signaling pathway
type: Class
subclass of: pattern recognition receptor signaling pathway
subclass of: GO_0030522
IAO_0000115: The series of molecular signals initiated by the binding of a ligand to an intracellular vesicle pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species.
has related synonym: intracellular vesicle PAMP receptor signaling pathway
has related synonym: intracellular vesicle pathogen receptor signaling pathway
has related synonym: intracellular vesicle pattern recognition receptor signaling pathway
has related synonym: intracellular vesicle pattern recognition receptor signalling pathway
has related synonym: intracellular vesicle PRR signaling pathway

MyD88-dependent toll-like receptor signaling pathway
type: Class
subclass of: toll-like receptor signaling pathway
IAO_0000115: A toll-like receptor signaling pathway in which the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response.
has exact synonym: MyD88-dependent TLR signaling pathway
has exact synonym: MyD88-dependent toll-like receptor signalling pathway

MyD88-independent toll-like receptor signaling pathway
type: Class
subclass of: toll-like receptor signaling pathway
IAO_0000115: A toll-like receptor signaling pathway not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate an immune response.
has exact synonym: MyD88-independent TLR signaling pathway
has exact synonym: MyD88-independent toll-like receptor signalling pathway

immune response-activating signal transduction
type: Class
subclass of: activation of immune response
subclass of: immune response-regulating signaling pathway
IAO_0000115: The series of molecular signals generated by a ligand binding to its receptor that ultimately lead to the activation or perpetuation of an immune response.

innate immune response-activating signal transduction
type: Class
subclass of: activation of innate immune response
subclass of: immune response-activating signal transduction
IAO_0000115: The series of molecular signals generated as a consequence of a pathogen or microbial effector binding to a plant 'resistance-gene' receptor to activate a plant immune response, usually plant-type hypersensitive response.
has related synonym: defence response signaling pathway, resistance gene-dependent
has related synonym: defence response signaling pathway, resistance gene-independent
has related synonym: defence response signalling pathway, resistance gene-dependent
has related synonym: defence response signalling pathway, resistance gene-independent
has related synonym: defense response signaling pathway, resistance gene-dependent
has related synonym: defense response signaling pathway, resistance gene-independent
has related synonym: defense response signalling pathway, resistance gene-dependent
has related synonym: effector-triggered immune signaling
has related synonym: effector triggered immunity
has related synonym: effector-triggered immunity
replaces: GO_0009870
replaces: GO_0010204

regulation of antimicrobial humoral response
type: Class
subclass of: regulation of response to biotic stimulus
subclass of: regulation of humoral immune response
subclass of: GO_0031347
subclass of: GO_0032101
IAO_0000115: Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response.

positive regulation of antimicrobial humoral response
type: Class
subclass of: regulation of antimicrobial humoral response
subclass of: positive regulation of response to biotic stimulus
subclass of: positive regulation of humoral immune response
subclass of: GO_0031349
subclass of: GO_0032103
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response.
has related synonym: activation of antimicrobial humoral response
has related synonym: stimulation of antimicrobial humoral response
has exact synonym: upregulation of antimicrobial humoral response
has exact synonym: up regulation of antimicrobial humoral response
has exact synonym: up-regulation of antimicrobial humoral response

regulation of myeloid leukocyte differentiation
type: Class
subclass of: GO_0045637
subclass of: GO_1902105
IAO_0000115: Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation.

negative regulation of myeloid leukocyte differentiation
type: Class
subclass of: regulation of myeloid leukocyte differentiation
subclass of: GO_0045638
subclass of: GO_1902106
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation.
has exact synonym: downregulation of myeloid leukocyte differentiation
has exact synonym: down regulation of myeloid leukocyte differentiation
has exact synonym: down-regulation of myeloid leukocyte differentiation
has related synonym: inhibition of myeloid leukocyte differentiation

positive regulation of myeloid leukocyte differentiation
type: Class
subclass of: regulation of myeloid leukocyte differentiation
subclass of: GO_0045639
subclass of: GO_1902107
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation.
has related synonym: activation of myeloid leukocyte differentiation
has related synonym: stimulation of myeloid leukocyte differentiation
has exact synonym: upregulation of myeloid leukocyte differentiation
has exact synonym: up regulation of myeloid leukocyte differentiation
has exact synonym: up-regulation of myeloid leukocyte differentiation

immune response-regulating signaling pathway
type: Class
subclass of: GO_0007165
subclass of: GO_0050776
IAO_0000115: The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response.
has exact synonym: immune response-regulating signalling pathway

immune response-inhibiting signal transduction
type: Class
subclass of: immune response-regulating signaling pathway
IAO_0000115: The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an immune response.

innate immune response-inhibiting signal transduction
type: Class
subclass of: immune response-inhibiting signal transduction
IAO_0000115: The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an innate immune response.

immune response-inhibiting cell surface receptor signaling pathway
type: Class
subclass of: immune response-inhibiting signal transduction
subclass of: immune response-regulating cell surface receptor signaling pathway
IAO_0000115: The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell capable of inhibiting an immune response.
has exact synonym: immune response-inhibiting cell surface receptor signalling pathway

immune response-regulating cell surface receptor signaling pathway
type: Class
subclass of: immune response-regulating signaling pathway
subclass of: GO_0007166
IAO_0000115: The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response.
has exact synonym: immune response-regulating cell surface receptor signalling pathway

natural killer cell inhibitory signaling pathway
type: Class
subclass of: immune response-inhibiting cell surface receptor signaling pathway
IAO_0000115: The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of a natural killer cell capable of inhibiting an immune effector process contributing to an immune response.
has related synonym: inhibitory KIR signaling pathway
has related synonym: killer cell inhibitory receptor signaling pathway
has related synonym: Ly49 inhibitory receptor signaling pathway
has exact synonym: natural killer cell inhibitory signalling pathway
has exact synonym: NK cell inhibitory signaling pathway

T cell inhibitory signaling pathway
type: Class
subclass of: immune response-inhibiting cell surface receptor signaling pathway
IAO_0000115: The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of a T cell capable of inhibiting an immune effector process contributing to an immune response.
has exact synonym: T-cell inhibitory signaling pathway
has exact synonym: T cell inhibitory signalling pathway
has exact synonym: T lymphocyte inhibitory signaling pathway
has exact synonym: T-lymphocyte inhibitory signaling pathway

inhibitory killer cell immunoglobulin-like receptor signaling pathway
type: Class
subclass of: immune response-inhibiting cell surface receptor signaling pathway
IAO_0000115: The series of molecular signals initiated by an extracellular ligand binding to a inhibitory killer cell immunoglobulin-like receptor capable of inhibiting an immune effector process contributing to an immune response.
has exact synonym: inhibitory killer cell immunoglobulin-like receptor signalling pathway
has exact synonym: killer cell inhibitory receptor signaling pathway
has exact synonym: KIR signaling pathway

inhibitory C-type lectin receptor signaling pathway
type: Class
subclass of: immune response-inhibiting cell surface receptor signaling pathway
IAO_0000115: The series of molecular signals initiated by an extracellular ligand binding to an inhibitory C-type lectin receptor capable of inhibiting an immune effector process contributing to an immune response.
has exact synonym: inhibitory C-type lectin receptor signalling pathway
has related synonym: Ly49 inhibitory receptor signaling pathway

B cell inhibitory signaling pathway
type: Class
subclass of: immune response-inhibiting cell surface receptor signaling pathway
IAO_0000115: The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of a B cell capable of inhibiting an immune effector process contributing to an immune response.
has exact synonym: B-cell inhibitory signaling pathway
has exact synonym: B cell inhibitory signalling pathway
has exact synonym: B lymphocyte inhibitory signaling pathwayBT-lymphocyte inhibitory signaling pathway

Fc receptor mediated inhibitory signaling pathway
type: Class
subclass of: immune response-inhibiting cell surface receptor signaling pathway
IAO_0000115: The series of molecular signals generated as a consequence of the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of inhibiting an immune effector process contributing to an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region.
has exact synonym: Fc-receptor mediated inhibitory signaling pathway
has exact synonym: Fc receptor mediated inhibitory signalling pathway

antimicrobial peptide production
type: Class
subclass of: production of molecular mediator of immune response
subclass of: part-of-parent-61844
IAO_0000115: The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa.

antimicrobial peptide secretion
type: Class
subclass of: peptide secretion
subclass of: part-of-parent-2775
IAO_0000115: The regulated release of an antimicrobial peptide from a cell or a tissue. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa.

antimicrobial peptide biosynthetic process
type: Class
subclass of: GO_0043043
subclass of: part-of-parent-2775
IAO_0000115: The chemical reactions and pathways resulting in the formation of an antimicrobial peptide. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa.

antibacterial peptide production
type: Class
subclass of: antimicrobial peptide production
subclass of: part-of-parent-19731
IAO_0000115: The synthesis or release of an antibacterial peptide during an immune response, resulting in an increase in intracellular or extracellular levels.

antibacterial peptide secretion
type: Class
subclass of: antimicrobial peptide secretion
subclass of: part-of-parent-2778
IAO_0000115: The regulated release of an antibacterial peptide from a cell or a tissue.

antibacterial peptide biosynthetic process
type: Class
subclass of: antimicrobial peptide biosynthetic process
subclass of: part-of-parent-2778
IAO_0000115: The chemical reactions and pathways resulting in the formation of an antibacterial peptide.

antifungal peptide production
type: Class
subclass of: antimicrobial peptide production
subclass of: part-of-parent-19732
IAO_0000115: The synthesis or release of an antifungal peptide during an immune response, resulting in an increase in intracellular or extracellular levels.

antifungal peptide secretion
type: Class
subclass of: antimicrobial peptide secretion
subclass of: part-of-parent-2781
IAO_0000115: The regulated release of an antifungal peptide from a cell or a tissue.

antifungal peptide biosynthetic process
type: Class
subclass of: antimicrobial peptide biosynthetic process
subclass of: part-of-parent-2781
IAO_0000115: The chemical reactions and pathways resulting in the formation of an antifungal peptide.

regulation of antimicrobial peptide production
type: Class
subclass of: regulation of production of molecular mediator of immune response
subclass of: regulation of antimicrobial humoral response
IAO_0000115: Any process that modulates the frequency, rate, or extent of antimicrobial peptide production.

negative regulation of antimicrobial peptide production
type: Class
subclass of: negative regulation of production of molecular mediator of immune response
subclass of: regulation of antimicrobial peptide production
subclass of: GO_0008348
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production.
has exact synonym: downregulation of antimicrobial peptide production
has exact synonym: down regulation of antimicrobial peptide production
has exact synonym: down-regulation of antimicrobial peptide production
has related synonym: inhibition of antimicrobial peptide production

regulation of antibacterial peptide production
type: Class
subclass of: regulation of antimicrobial peptide production
IAO_0000115: Any process that modulates the frequency, rate, or extent of antibacterial peptide production.

negative regulation of antibacterial peptide production
type: Class
subclass of: negative regulation of antimicrobial peptide production
subclass of: regulation of antibacterial peptide production
subclass of: GO_1900425
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide production.
has exact synonym: downregulation of antibacterial peptide production
has exact synonym: down regulation of antibacterial peptide production
has exact synonym: down-regulation of antibacterial peptide production
has related synonym: inhibition of antibacterial peptide production

regulation of antifungal peptide production
type: Class
subclass of: regulation of antimicrobial peptide production
subclass of: GO_1900150
IAO_0000115: Any process that modulates the frequency, rate, or extent of antifungal peptide production.

negative regulation of antifungal peptide production
type: Class
subclass of: negative regulation of antimicrobial peptide production
subclass of: regulation of antifungal peptide production
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide production.
has exact synonym: downregulation of antifungal peptide production
has exact synonym: down regulation of antifungal peptide production
has exact synonym: down-regulation of antifungal peptide production
has related synonym: inhibition of antifungal peptide production

peptide secretion
type: Class
subclass of: GO_0015833
subclass of: GO_0046903
IAO_0000115: The controlled release of a peptide from a cell or a tissue.

regulation of peptide secretion
type: Class
subclass of: GO_0051046
subclass of: GO_0090087
IAO_0000115: Any process that modulates the frequency, rate, or extent of peptide secretion.

negative regulation of peptide secretion
type: Class
subclass of: regulation of peptide secretion
subclass of: GO_0051048
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion.
has exact synonym: downregulation of peptide secretion
has exact synonym: down regulation of peptide secretion
has exact synonym: down-regulation of peptide secretion
has related synonym: inhibition of peptide secretion

positive regulation of peptide secretion
type: Class
subclass of: regulation of peptide secretion
subclass of: GO_0051047
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of peptide secretion.
has related synonym: activation of peptide secretion
has related synonym: stimulation of peptide secretion
has exact synonym: upregulation of peptide secretion
has exact synonym: up regulation of peptide secretion
has exact synonym: up-regulation of peptide secretion

regulation of antimicrobial peptide secretion
type: Class
subclass of: regulation of antimicrobial peptide production
subclass of: regulation of peptide secretion
IAO_0000115: Any process that modulates the frequency, rate, or extent of antimicrobial peptide secretion.

negative regulation of antimicrobial peptide secretion
type: Class
subclass of: negative regulation of antimicrobial peptide production
subclass of: negative regulation of peptide secretion
subclass of: regulation of antimicrobial peptide secretion
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide secretion.
has exact synonym: downregulation of antimicrobial peptide secretion
has exact synonym: down regulation of antimicrobial peptide secretion
has exact synonym: down-regulation of antimicrobial peptide secretion
has related synonym: inhibition of antimicrobial peptide secretion

positive regulation of antimicrobial peptide secretion
type: Class
subclass of: positive regulation of antimicrobial peptide production
subclass of: positive regulation of peptide secretion
subclass of: regulation of antimicrobial peptide secretion
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide secretion.
has related synonym: activation of antimicrobial peptide secretion
has related synonym: stimulation of antimicrobial peptide secretion
has exact synonym: upregulation of antimicrobial peptide secretion
has exact synonym: up regulation of antimicrobial peptide secretion
has exact synonym: up-regulation of antimicrobial peptide secretion

regulation of antibacterial peptide secretion
type: Class
subclass of: regulation of antibacterial peptide production
subclass of: regulation of antimicrobial peptide secretion
IAO_0000115: Any process that modulates the frequency, rate, or extent of antibacterial peptide secretion.

negative regulation of antibacterial peptide secretion
type: Class
subclass of: negative regulation of antibacterial peptide production
subclass of: negative regulation of antimicrobial peptide secretion
subclass of: regulation of antibacterial peptide secretion
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide secretion.
has exact synonym: downregulation of antibacterial peptide secretion
has exact synonym: down regulation of antibacterial peptide secretion
has exact synonym: down-regulation of antibacterial peptide secretion
has related synonym: inhibition of antibacterial peptide secretion

positive regulation of antibacterial peptide secretion
type: Class
subclass of: positive regulation of antimicrobial peptide secretion
subclass of: regulation of antibacterial peptide secretion
subclass of: positive regulation of antibacterial peptide production
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antibacterial peptide secretion.
has related synonym: activation of antibacterial peptide secretion
has related synonym: stimulation of antibacterial peptide secretion
has exact synonym: upregulation of antibacterial peptide secretion
has exact synonym: up regulation of antibacterial peptide secretion
has exact synonym: up-regulation of antibacterial peptide secretion

regulation of antifungal peptide secretion
type: Class
subclass of: regulation of antifungal peptide production
subclass of: regulation of antimicrobial peptide secretion
IAO_0000115: Any process that modulates the frequency, rate, or extent of antifungal peptide secretion.

negative regulation of antifungal peptide secretion
type: Class
subclass of: negative regulation of antifungal peptide production
subclass of: negative regulation of antimicrobial peptide secretion
subclass of: regulation of antifungal peptide secretion
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide secretion.
has exact synonym: downregulation of antifungal peptide secretion
has exact synonym: down regulation of antifungal peptide secretion
has exact synonym: down-regulation of antifungal peptide secretion
has related synonym: inhibition of antifungal peptide secretion

positive regulation of antifungal peptide secretion
type: Class
subclass of: positive regulation of antimicrobial peptide secretion
subclass of: regulation of antifungal peptide secretion
subclass of: positive regulation of antifungal peptide production
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antifungal peptide secretion.
has related synonym: activation of antifungal peptide secretion
has related synonym: stimulation of antifungal peptide secretion
has exact synonym: upregulation of antifungal peptide secretion
has exact synonym: up regulation of antifungal peptide secretion
has exact synonym: up-regulation of antifungal peptide secretion

positive regulation of antibacterial peptide production
type: Class
subclass of: positive regulation of antimicrobial peptide production
subclass of: regulation of antibacterial peptide production
subclass of: GO_1900426
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antibacterial peptide production.
has related synonym: activation of antibacterial peptide production
has related synonym: stimulation of antibacterial peptide production
has exact synonym: upregulation of antibacterial peptide production
has exact synonym: up regulation of antibacterial peptide production
has exact synonym: up-regulation of antibacterial peptide production

positive regulation of antifungal peptide production
type: Class
subclass of: positive regulation of antimicrobial peptide production
subclass of: regulation of antifungal peptide production
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antifungal peptide production.
has related synonym: activation of antifungal peptide production
has related synonym: stimulation of antifungal peptide production
has exact synonym: upregulation of antifungal peptide production
has exact synonym: up regulation of antifungal peptide production
has exact synonym: up-regulation of antifungal peptide production

regulation of antimicrobial peptide biosynthetic process
type: Class
subclass of: regulation of antimicrobial peptide production
subclass of: GO_0031326
subclass of: GO_0034248
IAO_0000115: Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis.

negative regulation of antimicrobial peptide biosynthetic process
type: Class
subclass of: negative regulation of antimicrobial peptide production
subclass of: regulation of antimicrobial peptide biosynthetic process
subclass of: GO_0031327
subclass of: GO_0034249
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide biosynthesis.
has exact synonym: downregulation of antimicrobial peptide biosynthetic process
has exact synonym: down regulation of antimicrobial peptide biosynthetic process
has exact synonym: down-regulation of antimicrobial peptide biosynthetic process
has related synonym: inhibition of antimicrobial peptide biosynthetic process

positive regulation of antimicrobial peptide biosynthetic process
type: Class
subclass of: positive regulation of antimicrobial peptide production
subclass of: regulation of antimicrobial peptide biosynthetic process
subclass of: GO_0031328
subclass of: GO_0034250
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis.
has related synonym: activation of antimicrobial peptide biosynthetic process
has related synonym: stimulation of antimicrobial peptide biosynthetic process
has exact synonym: upregulation of antimicrobial peptide biosynthetic process
has exact synonym: up regulation of antimicrobial peptide biosynthetic process
has exact synonym: up-regulation of antimicrobial peptide biosynthetic process

regulation of antibacterial peptide biosynthetic process
type: Class
subclass of: regulation of antibacterial peptide production
subclass of: regulation of antimicrobial peptide biosynthetic process
IAO_0000115: Any process that modulates the frequency, rate, or extent of antibacterial peptide biosynthesis.

negative regulation of antibacterial peptide biosynthetic process
type: Class
subclass of: negative regulation of antibacterial peptide production
subclass of: negative regulation of antimicrobial peptide biosynthetic process
subclass of: regulation of antibacterial peptide biosynthetic process
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide biosynthesis.
has exact synonym: downregulation of antibacterial peptide biosynthetic process
has exact synonym: down regulation of antibacterial peptide biosynthetic process
has exact synonym: down-regulation of antibacterial peptide biosynthetic process
has related synonym: inhibition of antibacterial peptide biosynthetic process

regulation of antifungal peptide biosynthetic process
type: Class
subclass of: regulation of antifungal peptide production
subclass of: regulation of antimicrobial peptide biosynthetic process
IAO_0000115: Any process that modulates the frequency, rate, or extent of antifungal peptide biosynthesis.

negative regulation of antifungal peptide biosynthetic process
type: Class
subclass of: negative regulation of antifungal peptide production
subclass of: negative regulation of antimicrobial peptide biosynthetic process
subclass of: regulation of antifungal peptide biosynthetic process
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide biosynthesis.
has exact synonym: downregulation of antifungal peptide biosynthetic process
has exact synonym: down regulation of antifungal peptide biosynthetic process
has exact synonym: down-regulation of antifungal peptide biosynthetic process
has related synonym: inhibition of antifungal peptide biosynthetic process

biosynthetic process of antibacterial peptides active against Gram-negative bacteria
type: Class
subclass of: antibacterial peptide biosynthetic process
subclass of: part-of-parent-50829
IAO_0000115: The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-negative bacteria.

regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
type: Class
subclass of: regulation of antibacterial peptide biosynthetic process
IAO_0000115: Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria.

negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
type: Class
subclass of: negative regulation of antibacterial peptide biosynthetic process
subclass of: regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria.
has exact synonym: downregulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
has exact synonym: down regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
has exact synonym: down-regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
has related synonym: inhibition of biosynthetic process of antibacterial peptides active against Gram-negative bacteria

biosynthetic process of antibacterial peptides active against Gram-positive bacteria
type: Class
subclass of: antibacterial peptide biosynthetic process
subclass of: part-of-parent-50830
IAO_0000115: The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-positive bacteria.

regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
type: Class
subclass of: regulation of antibacterial peptide biosynthetic process
IAO_0000115: Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria.

negative regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
type: Class
subclass of: negative regulation of antibacterial peptide biosynthetic process
subclass of: regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria.
has exact synonym: downregulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
has exact synonym: down regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
has exact synonym: down-regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
has related synonym: inhibition of biosynthetic process of antibacterial peptides active against Gram-positive bacteria

regulation of adaptive immune response
type: Class
subclass of: GO_0050776
IAO_0000115: Any process that modulates the frequency, rate, or extent of an adaptive immune response.

negative regulation of adaptive immune response
type: Class
subclass of: regulation of adaptive immune response
subclass of: GO_0050777
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response.
has exact synonym: downregulation of adaptive immune response
has exact synonym: down regulation of adaptive immune response
has exact synonym: down-regulation of adaptive immune response
has related synonym: inhibition of adaptive immune response

positive regulation of adaptive immune response
type: Class
subclass of: regulation of adaptive immune response
subclass of: GO_0050778
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.
has related synonym: activation of adaptive immune response
has related synonym: stimulation of adaptive immune response
has exact synonym: upregulation of adaptive immune response
has exact synonym: up regulation of adaptive immune response
has exact synonym: up-regulation of adaptive immune response

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
type: Class
subclass of: regulation of adaptive immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
type: Class
subclass of: negative regulation of adaptive immune response
subclass of: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
type: Class
subclass of: positive regulation of adaptive immune response
subclass of: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.

regulation of T-helper 1 type immune response
type: Class
subclass of: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
IAO_0000115: Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response.

negative regulation of T-helper 1 type immune response
type: Class
subclass of: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: regulation of T-helper 1 type immune response
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response.
has exact synonym: downregulation of T-helper 1 type immune response
has exact synonym: down regulation of T-helper 1 type immune response
has exact synonym: down-regulation of T-helper 1 type immune response
has related synonym: inhibition of T-helper 1 type immune response

positive regulation of T-helper 1 type immune response
type: Class
subclass of: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: regulation of T-helper 1 type immune response
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response.
has related synonym: activation of T-helper 1 type immune response
has related synonym: stimulation of T-helper 1 type immune response
has exact synonym: upregulation of T-helper 1 type immune response
has exact synonym: up regulation of T-helper 1 type immune response
has exact synonym: up-regulation of T-helper 1 type immune response

regulation of type 2 immune response
type: Class
subclass of: GO_0050776
IAO_0000115: Any process that modulates the frequency, rate, or extent of a type 2 immune response.
has related synonym: regulation of Th2 immune response
has related synonym: regulation of T-helper 2 type immune response

negative regulation of type 2 immune response
type: Class
subclass of: regulation of type 2 immune response
subclass of: GO_0050777
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response.
has exact synonym: downregulation of type 2 immune response
has exact synonym: down regulation of type 2 immune response
has exact synonym: down-regulation of type 2 immune response
has related synonym: inhibition of type 2 immune response
has related synonym: negative regulation of Th2 immune response
has related synonym: negative regulation of T-helper 2 type immune response

positive regulation of type 2 immune response
type: Class
subclass of: regulation of type 2 immune response
subclass of: GO_0050778
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a type 2 immune response.
has related synonym: activation of type 2 immune response
has related synonym: positive regulation of Th2 immune response
has related synonym: positive regulation of T-helper 2 type immune response
has related synonym: stimulation of type 2 immune response
has exact synonym: upregulation of type 2 immune response
has exact synonym: up regulation of type 2 immune response
has exact synonym: up-regulation of type 2 immune response

regulation of response to biotic stimulus
type: Class
subclass of: GO_0048583
IAO_0000115: Any process that modulates the frequency, rate, or extent of a response to biotic stimulus.

negative regulation of response to biotic stimulus
type: Class
subclass of: regulation of response to biotic stimulus
subclass of: GO_0048585
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus.
has exact synonym: downregulation of response to biotic stimulus
has exact synonym: down regulation of response to biotic stimulus
has exact synonym: down-regulation of response to biotic stimulus
has related synonym: inhibition of response to biotic stimulus

positive regulation of response to biotic stimulus
type: Class
subclass of: regulation of response to biotic stimulus
subclass of: GO_0048584
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus.
has related synonym: activation of response to biotic stimulus
has related synonym: stimulation of response to biotic stimulus
has exact synonym: upregulation of response to biotic stimulus
has exact synonym: up regulation of response to biotic stimulus
has exact synonym: up-regulation of response to biotic stimulus

regulation of response to tumor cell
type: Class
subclass of: regulation of response to biotic stimulus
IAO_0000115: Any process that modulates the frequency, rate, or extent of a response to tumor cell.
has exact synonym: regulation of response to tumour cell

negative regulation of response to tumor cell
type: Class
subclass of: negative regulation of response to biotic stimulus
subclass of: regulation of response to tumor cell
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to tumor cell.
has exact synonym: downregulation of response to tumor cell
has exact synonym: down regulation of response to tumor cell
has exact synonym: down-regulation of response to tumor cell
has related synonym: inhibition of response to tumor cell
has exact synonym: negative regulation of response to tumour cell

positive regulation of response to tumor cell
type: Class
subclass of: positive regulation of response to biotic stimulus
subclass of: regulation of response to tumor cell
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a response to tumor cell.
has related synonym: activation of response to tumor cell
has exact synonym: positive regulation of response to tumour cell
has related synonym: stimulation of response to tumor cell
has exact synonym: upregulation of response to tumor cell
has exact synonym: up regulation of response to tumor cell
has exact synonym: up-regulation of response to tumor cell

regulation of immune response to tumor cell
type: Class
subclass of: regulation of response to tumor cell
subclass of: GO_0050776
IAO_0000115: Any process that modulates the frequency, rate, or extent of an immune response to tumor cell.
has exact synonym: regulation of immune response to tumour cell

negative regulation of immune response to tumor cell
type: Class
subclass of: negative regulation of response to tumor cell
subclass of: regulation of immune response to tumor cell
subclass of: GO_0050777
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune response to tumor cell.
has exact synonym: downregulation of immune response to tumor cell
has exact synonym: down regulation of immune response to tumor cell
has exact synonym: down-regulation of immune response to tumor cell
has related synonym: inhibition of immune response to tumor cell
has exact synonym: negative regulation of immune response to tumour cell

positive regulation of immune response to tumor cell
type: Class
subclass of: positive regulation of response to tumor cell
subclass of: regulation of immune response to tumor cell
subclass of: GO_0050778
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell.
has related synonym: activation of immune response to tumor cell
has exact synonym: positive regulation of immune response to tumour cell
has related synonym: stimulation of immune response to tumor cell
has exact synonym: upregulation of immune response to tumor cell
has exact synonym: up regulation of immune response to tumor cell
has exact synonym: up-regulation of immune response to tumor cell

regulation of T cell mediated immune response to tumor cell
type: Class
subclass of: regulation of T cell mediated immunity
subclass of: regulation of immune response to tumor cell
IAO_0000115: Any process that modulates the frequency, rate, or extent of a T cell mediated immune response to tumor cell.
has exact synonym: regulation of T-cell mediated immune response to tumor cell
has exact synonym: regulation of T cell mediated immune response to tumour cell
has exact synonym: regulation of T lymphocyte mediated immune response to tumor cell
has exact synonym: regulation of T-lymphocyte mediated immune response to tumor cell

negative regulation of T cell mediated immune response to tumor cell
type: Class
subclass of: negative regulation of T cell mediated immunity
subclass of: negative regulation of immune response to tumor cell
subclass of: regulation of T cell mediated immune response to tumor cell
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a T cell mediated immune response to tumor cell.
has exact synonym: downregulation of T cell mediated immune response to tumor cell
has exact synonym: down regulation of T cell mediated immune response to tumor cell
has exact synonym: down-regulation of T cell mediated immune response to tumor cell
has related synonym: inhibition of T cell mediated immune response to tumor cell
has exact synonym: negative regulation of T-cell mediated immune response to tumor cell
has exact synonym: negative regulation of T cell mediated immune response to tumour cell
has exact synonym: negative regulation of T lymphocyte mediated immune response to tumor cell
has exact synonym: negative regulation of T-lymphocyte mediated immune response to tumor cell

positive regulation of T cell mediated immune response to tumor cell
type: Class
subclass of: positive regulation of T cell mediated immunity
subclass of: positive regulation of immune response to tumor cell
subclass of: regulation of T cell mediated immune response to tumor cell
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a T cell mediated immune response to tumor cell.
has related synonym: activation of T cell mediated immune response to tumor cell
has exact synonym: positive regulation of T-cell mediated immune response to tumor cell
has exact synonym: positive regulation of T cell mediated immune response to tumour cell
has exact synonym: positive regulation of T lymphocyte mediated immune response to tumor cell
has exact synonym: positive regulation of T-lymphocyte mediated immune response to tumor cell
has related synonym: stimulation of T cell mediated immune response to tumor cell
has exact synonym: upregulation of T cell mediated immune response to tumor cell
has exact synonym: up regulation of T cell mediated immune response to tumor cell
has exact synonym: up-regulation of T cell mediated immune response to tumor cell

regulation of tolerance induction to tumor cell
type: Class
subclass of: regulation of peripheral tolerance induction
subclass of: regulation of immune response to tumor cell
IAO_0000115: Any process that modulates the frequency, rate, or extent of tolerance induction to tumor cell.
has exact synonym: regulation of tolerance induction to tumour cell

negative regulation of tolerance induction to tumor cell
type: Class
subclass of: negative regulation of peripheral tolerance induction
subclass of: negative regulation of immune response to tumor cell
subclass of: regulation of tolerance induction to tumor cell
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to tumor cell.
has exact synonym: downregulation of tolerance induction to tumor cell
has exact synonym: down regulation of tolerance induction to tumor cell
has exact synonym: down-regulation of tolerance induction to tumor cell
has related synonym: inhibition of tolerance induction to tumor cell
has exact synonym: negative regulation of tolerance induction to tumour cell

positive regulation of tolerance induction to tumor cell
type: Class
subclass of: positive regulation of peripheral tolerance induction
subclass of: positive regulation of immune response to tumor cell
subclass of: regulation of tolerance induction to tumor cell
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of tolerance induction to tumor cell.
has related synonym: activation of tolerance induction to tumor cell
has exact synonym: positive regulation of tolerance induction to tumour cell
has related synonym: stimulation of tolerance induction to tumor cell
has exact synonym: upregulation of tolerance induction to tumor cell
has exact synonym: up regulation of tolerance induction to tumor cell
has exact synonym: up-regulation of tolerance induction to tumor cell

regulation of T cell tolerance induction to tumor cell
type: Class
subclass of: regulation of T cell mediated immune response to tumor cell
subclass of: regulation of tolerance induction to tumor cell
subclass of: regulation of peripheral T cell tolerance induction
IAO_0000115: Any process that modulates the frequency, rate, or extent of T cell tolerance induction to tumor cell.

negative regulation of T cell tolerance induction to tumor cell
type: Class
subclass of: negative regulation of T cell mediated immune response to tumor cell
subclass of: negative regulation of tolerance induction to tumor cell
subclass of: regulation of T cell tolerance induction to tumor cell
subclass of: negative regulation of peripheral T cell tolerance induction
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction to tumor cell.
has exact synonym: downregulation of T cell tolerance induction to tumor cell
has exact synonym: down regulation of T cell tolerance induction to tumor cell
has exact synonym: down-regulation of T cell tolerance induction to tumor cell
has related synonym: inhibition of T cell tolerance induction to tumor cell

positive regulation of T cell tolerance induction to tumor cell
type: Class
subclass of: positive regulation of T cell mediated immune response to tumor cell
subclass of: positive regulation of tolerance induction to tumor cell
subclass of: regulation of T cell tolerance induction to tumor cell
subclass of: positive regulation of peripheral T cell tolerance induction
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction to tumor cell.
has related synonym: activation of T cell tolerance induction to tumor cell
has related synonym: stimulation of T cell tolerance induction to tumor cell
has exact synonym: upregulation of T cell tolerance induction to tumor cell
has exact synonym: up regulation of T cell tolerance induction to tumor cell
has exact synonym: up-regulation of T cell tolerance induction to tumor cell

regulation of peripheral T cell tolerance induction
type: Class
subclass of: regulation of peripheral tolerance induction
subclass of: regulation of T cell tolerance induction
subclass of: regulation of T cell mediated immunity
IAO_0000115: Any process that modulates the frequency, rate, or extent of peripheral T cell tolerance induction.

negative regulation of peripheral T cell tolerance induction
type: Class
subclass of: negative regulation of peripheral tolerance induction
subclass of: negative regulation of T cell tolerance induction
subclass of: negative regulation of T cell mediated immunity
subclass of: regulation of peripheral T cell tolerance induction
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral T cell tolerance induction.
has exact synonym: downregulation of peripheral T cell tolerance induction
has exact synonym: down regulation of peripheral T cell tolerance induction
has exact synonym: down-regulation of peripheral T cell tolerance induction
has related synonym: inhibition of peripheral T cell tolerance induction

positive regulation of peripheral T cell tolerance induction
type: Class
subclass of: positive regulation of peripheral tolerance induction
subclass of: positive regulation of T cell tolerance induction
subclass of: positive regulation of T cell mediated immunity
subclass of: regulation of peripheral T cell tolerance induction
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of peripheral T cell tolerance induction.
has related synonym: activation of peripheral T cell tolerance induction
has related synonym: stimulation of peripheral T cell tolerance induction
has exact synonym: upregulation of peripheral T cell tolerance induction
has exact synonym: up regulation of peripheral T cell tolerance induction
has exact synonym: up-regulation of peripheral T cell tolerance induction

regulation of T cell mediated cytotoxicity directed against tumor cell target
type: Class
subclass of: regulation of T cell mediated cytotoxicity
subclass of: regulation of T cell mediated immune response to tumor cell
IAO_0000115: Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target.

negative regulation of T cell mediated cytotoxicity directed against tumor cell target
type: Class
subclass of: negative regulation of T cell mediated cytotoxicity
subclass of: negative regulation of T cell mediated immune response to tumor cell
subclass of: regulation of T cell mediated cytotoxicity directed against tumor cell target
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target.
has exact synonym: downregulation of T cell mediated cytotoxicity directed against tumor cell target
has exact synonym: down regulation of T cell mediated cytotoxicity directed against tumor cell target
has exact synonym: down-regulation of T cell mediated cytotoxicity directed against tumor cell target
has related synonym: inhibition of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated cytotoxicity directed against tumor cell target
type: Class
subclass of: positive regulation of T cell mediated cytotoxicity
subclass of: positive regulation of T cell mediated immune response to tumor cell
subclass of: regulation of T cell mediated cytotoxicity directed against tumor cell target
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target.
has related synonym: activation of T cell mediated cytotoxicity directed against tumor cell target
has related synonym: stimulation of T cell mediated cytotoxicity directed against tumor cell target
has exact synonym: upregulation of T cell mediated cytotoxicity directed against tumor cell target
has exact synonym: up regulation of T cell mediated cytotoxicity directed against tumor cell target
has exact synonym: up-regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of natural killer cell mediated immune response to tumor cell
type: Class
subclass of: regulation of natural killer cell mediated immunity
subclass of: regulation of immune response to tumor cell
IAO_0000115: Any process that modulates the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell.

negative regulation of natural killer cell mediated immune response to tumor cell
type: Class
subclass of: negative regulation of natural killer cell mediated immunity
subclass of: negative regulation of immune response to tumor cell
subclass of: regulation of natural killer cell mediated immune response to tumor cell
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell.
has exact synonym: downregulation of natural killer cell mediated immune response to tumor cell
has exact synonym: down regulation of natural killer cell mediated immune response to tumor cell
has exact synonym: down-regulation of natural killer cell mediated immune response to tumor cell
has related synonym: inhibition of natural killer cell mediated immune response to tumor cell

positive regulation of natural killer cell mediated immune response to tumor cell
type: Class
subclass of: positive regulation of natural killer cell mediated immunity
subclass of: positive regulation of immune response to tumor cell
subclass of: regulation of natural killer cell mediated immune response to tumor cell
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell.
has related synonym: activation of natural killer cell mediated immune response to tumor cell
has related synonym: stimulation of natural killer cell mediated immune response to tumor cell
has exact synonym: upregulation of natural killer cell mediated immune response to tumor cell
has exact synonym: up regulation of natural killer cell mediated immune response to tumor cell
has exact synonym: up-regulation of natural killer cell mediated immune response to tumor cell

regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
type: Class
subclass of: regulation of natural killer cell mediated immune response to tumor cell
subclass of: GO_0042269
IAO_0000115: Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target.

negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
type: Class
subclass of: negative regulation of natural killer cell mediated immune response to tumor cell
subclass of: regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
subclass of: GO_0045953
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target.
has exact synonym: downregulation of natural killer cell mediated cytotoxicity directed against tumor cell target
has exact synonym: down regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
has exact synonym: down-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
has related synonym: inhibition of natural killer cell mediated cytotoxicity directed against tumor cell target

positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
type: Class
subclass of: positive regulation of natural killer cell mediated immune response to tumor cell
subclass of: regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
subclass of: GO_0045954
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target.
has related synonym: activation of natural killer cell mediated cytotoxicity directed against tumor cell target
has related synonym: stimulation of natural killer cell mediated cytotoxicity directed against tumor cell target
has exact synonym: upregulation of natural killer cell mediated cytotoxicity directed against tumor cell target
has exact synonym: up regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
has exact synonym: up-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

regulation of inflammatory response to antigenic stimulus
type: Class
subclass of: GO_0050727
subclass of: GO_0050776
IAO_0000115: Any process that modulates the frequency, rate, or extent of an inflammatory response to an antigenic stimulus.

negative regulation of inflammatory response to antigenic stimulus
type: Class
subclass of: regulation of inflammatory response to antigenic stimulus
subclass of: GO_0050728
subclass of: GO_0050777
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus.
has exact synonym: downregulation of inflammatory response to antigenic stimulus
has exact synonym: down regulation of inflammatory response to antigenic stimulus
has exact synonym: down-regulation of inflammatory response to antigenic stimulus
has related synonym: inhibition of inflammatory response to antigenic stimulus

positive regulation of inflammatory response to antigenic stimulus
type: Class
subclass of: regulation of inflammatory response to antigenic stimulus
subclass of: GO_0050729
subclass of: GO_0050778
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an inflammatory response to an antigenic stimulus.
has related synonym: activation of inflammatory response to antigenic stimulus
has related synonym: stimulation of inflammatory response to antigenic stimulus
has exact synonym: upregulation of inflammatory response to antigenic stimulus
has exact synonym: up regulation of inflammatory response to antigenic stimulus
has exact synonym: up-regulation of inflammatory response to antigenic stimulus

regulation of acute inflammatory response to antigenic stimulus
type: Class
subclass of: regulation of acute inflammatory response
subclass of: regulation of inflammatory response to antigenic stimulus
IAO_0000115: Any process that modulates the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus.

negative regulation of acute inflammatory response to antigenic stimulus
type: Class
subclass of: negative regulation of acute inflammatory response
subclass of: negative regulation of inflammatory response to antigenic stimulus
subclass of: regulation of acute inflammatory response to antigenic stimulus
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus.
has exact synonym: downregulation of acute inflammatory response to antigenic stimulus
has exact synonym: down regulation of acute inflammatory response to antigenic stimulus
has exact synonym: down-regulation of acute inflammatory response to antigenic stimulus
has related synonym: inhibition of acute inflammatory response to antigenic stimulus

positive regulation of acute inflammatory response to antigenic stimulus
type: Class
subclass of: positive regulation of acute inflammatory response
subclass of: positive regulation of inflammatory response to antigenic stimulus
subclass of: regulation of acute inflammatory response to antigenic stimulus
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus.
has related synonym: activation of acute inflammatory response to antigenic stimulus
has related synonym: stimulation of acute inflammatory response to antigenic stimulus
has exact synonym: upregulation of acute inflammatory response to antigenic stimulus
has exact synonym: up regulation of acute inflammatory response to antigenic stimulus
has exact synonym: up-regulation of acute inflammatory response to antigenic stimulus

regulation of B cell deletion
type: Class
subclass of: regulation of B cell tolerance induction
subclass of: regulation of B cell apoptotic process
subclass of: GO_1904748
IAO_0000115: Any process that modulates the frequency, rate, or extent of B cell deletion.
has exact synonym: regulation of B-cell deletion
has exact synonym: regulation of B lymphocyte deletion
has exact synonym: regulation of B-lymphocyte deletion

negative regulation of B cell deletion
type: Class
subclass of: negative regulation of B cell tolerance induction
subclass of: regulation of acute inflammatory response
subclass of: regulation of B cell deletion
subclass of: negative regulation of B cell apoptotic process
subclass of: GO_1904746
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell deletion.
has exact synonym: downregulation of B cell deletion
has exact synonym: down regulation of B cell deletion
has exact synonym: down-regulation of B cell deletion
has related synonym: inhibition of B cell deletion
has exact synonym: negative regulation of B-cell deletion
has exact synonym: negative regulation of B lymphocyte deletion
has exact synonym: negative regulation of B-lymphocyte deletion

positive regulation of B cell deletion
type: Class
subclass of: positive regulation of B cell tolerance induction
subclass of: regulation of acute inflammatory response
subclass of: regulation of B cell deletion
subclass of: positive regulation of B cell apoptotic process
subclass of: GO_1904747
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of B cell deletion.
has related synonym: activation of B cell deletion
has exact synonym: positive regulation of B-cell deletion
has exact synonym: positive regulation of B lymphocyte deletion
has exact synonym: positive regulation of B-lymphocyte deletion
has related synonym: stimulation of B cell deletion
has exact synonym: upregulation of B cell deletion
has exact synonym: up regulation of B cell deletion
has exact synonym: up-regulation of B cell deletion

T cell anergy
type: Class
subclass of: lymphocyte anergy
subclass of: T cell tolerance induction
IAO_0000115: Any process contributing to anergy in T cells, a state of functional inactivation which is part of T cell tolerance induction.
has exact synonym: T-cell anergy
has exact synonym: T lymphocyte anergy
has exact synonym: T-lymphocyte anergy

regulation of natural killer cell tolerance induction
type: Class
subclass of: regulation of tolerance induction
IAO_0000115: Any process that modulates the frequency, rate, or extent of natural killer cell tolerance induction.
has exact synonym: regulation of NK cell tolerance induction

negative regulation of natural killer cell tolerance induction
type: Class
subclass of: negative regulation of tolerance induction
subclass of: regulation of acute inflammatory response
subclass of: regulation of natural killer cell tolerance induction
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell tolerance induction.
has exact synonym: downregulation of natural killer cell tolerance induction
has exact synonym: down regulation of natural killer cell tolerance induction
has exact synonym: down-regulation of natural killer cell tolerance induction
has related synonym: inhibition of natural killer cell tolerance induction
has exact synonym: negative regulation of NK cell tolerance induction

positive regulation of natural killer cell tolerance induction
type: Class
subclass of: positive regulation of tolerance induction
subclass of: regulation of acute inflammatory response
subclass of: regulation of natural killer cell tolerance induction
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of natural killer cell tolerance induction.
has related synonym: activation of natural killer cell tolerance induction
has exact synonym: positive regulation of NK cell tolerance induction
has related synonym: stimulation of natural killer cell tolerance induction
has exact synonym: upregulation of natural killer cell tolerance induction
has exact synonym: up regulation of natural killer cell tolerance induction
has exact synonym: up-regulation of natural killer cell tolerance induction

regulation of chronic inflammatory response to antigenic stimulus
type: Class
subclass of: regulation of chronic inflammatory response
subclass of: regulation of inflammatory response to antigenic stimulus
IAO_0000115: Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus.

negative regulation of chronic inflammatory response to antigenic stimulus
type: Class
subclass of: negative regulation of chronic inflammatory response
subclass of: negative regulation of inflammatory response to antigenic stimulus
subclass of: regulation of chronic inflammatory response to antigenic stimulus
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus.
has exact synonym: downregulation of chronic inflammatory response to antigenic stimulus
has exact synonym: down regulation of chronic inflammatory response to antigenic stimulus
has exact synonym: down-regulation of chronic inflammatory response to antigenic stimulus
has related synonym: inhibition of chronic inflammatory response to antigenic stimulus

positive regulation of chronic inflammatory response to antigenic stimulus
type: Class
subclass of: positive regulation of chronic inflammatory response
subclass of: positive regulation of inflammatory response to antigenic stimulus
subclass of: regulation of chronic inflammatory response to antigenic stimulus
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus.
has related synonym: activation of chronic inflammatory response to antigenic stimulus
has related synonym: stimulation of chronic inflammatory response to antigenic stimulus
has exact synonym: upregulation of chronic inflammatory response to antigenic stimulus
has exact synonym: up regulation of chronic inflammatory response to antigenic stimulus
has exact synonym: up-regulation of chronic inflammatory response to antigenic stimulus

regulation of acute inflammatory response to non-antigenic stimulus
type: Class
subclass of: regulation of acute inflammatory response
IAO_0000115: Any process that modulates the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus.

negative regulation of acute inflammatory response to non-antigenic stimulus
type: Class
subclass of: negative regulation of acute inflammatory response
subclass of: regulation of acute inflammatory response to non-antigenic stimulus
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus.
has exact synonym: downregulation of acute inflammatory response to non-antigenic stimulus
has exact synonym: down regulation of acute inflammatory response to non-antigenic stimulus
has exact synonym: down-regulation of acute inflammatory response to non-antigenic stimulus
has related synonym: inhibition of acute inflammatory response to non-antigenic stimulus

positive regulation of acute inflammatory response to non-antigenic stimulus
type: Class
subclass of: positive regulation of acute inflammatory response
subclass of: regulation of acute inflammatory response to non-antigenic stimulus
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus.
has related synonym: activation of acute inflammatory response to non-antigenic stimulus
has related synonym: stimulation of acute inflammatory response to non-antigenic stimulus
has exact synonym: upregulation of acute inflammatory response to non-antigenic stimulus
has exact synonym: up regulation of acute inflammatory response to non-antigenic stimulus
has exact synonym: up-regulation of acute inflammatory response to non-antigenic stimulus

regulation of chronic inflammatory response to non-antigenic stimulus
type: Class
subclass of: regulation of chronic inflammatory response
IAO_0000115: Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus.

negative regulation of chronic inflammatory response to non-antigenic stimulus
type: Class
subclass of: negative regulation of chronic inflammatory response
subclass of: regulation of chronic inflammatory response to non-antigenic stimulus
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus.
has exact synonym: downregulation of chronic inflammatory response to non-antigenic stimulus
has exact synonym: down regulation of chronic inflammatory response to non-antigenic stimulus
has exact synonym: down-regulation of chronic inflammatory response to non-antigenic stimulus
has related synonym: inhibition of chronic inflammatory response to non-antigenic stimulus

positive regulation of chronic inflammatory response to non-antigenic stimulus
type: Class
subclass of: positive regulation of chronic inflammatory response
subclass of: regulation of chronic inflammatory response to non-antigenic stimulus
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus.
has related synonym: activation of chronic inflammatory response to non-antigenic stimulus
has related synonym: stimulation of chronic inflammatory response to non-antigenic stimulus
has exact synonym: upregulation of chronic inflammatory response to non-antigenic stimulus
has exact synonym: up regulation of chronic inflammatory response to non-antigenic stimulus
has exact synonym: up-regulation of chronic inflammatory response to non-antigenic stimulus

regulation of hypersensitivity
type: Class
subclass of: regulation of acute inflammatory response to antigenic stimulus
IAO_0000115: Any process that modulates the frequency, rate, or extent of hypersensitivity.

negative regulation of hypersensitivity
type: Class
subclass of: negative regulation of acute inflammatory response to antigenic stimulus
subclass of: regulation of hypersensitivity
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of hypersensitivity.
has exact synonym: downregulation of hypersensitivity
has exact synonym: down regulation of hypersensitivity
has exact synonym: down-regulation of hypersensitivity
has related synonym: inhibition of hypersensitivity

positive regulation of hypersensitivity
type: Class
subclass of: positive regulation of acute inflammatory response to antigenic stimulus
subclass of: regulation of hypersensitivity
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of hypersensitivity.
has related synonym: activation of hypersensitivity
has related synonym: stimulation of hypersensitivity
has exact synonym: upregulation of hypersensitivity
has exact synonym: up regulation of hypersensitivity
has exact synonym: up-regulation of hypersensitivity

regulation of myeloid leukocyte mediated immunity
type: Class
subclass of: regulation of leukocyte mediated immunity
IAO_0000115: Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity.

negative regulation of myeloid leukocyte mediated immunity
type: Class
subclass of: negative regulation of leukocyte mediated immunity
subclass of: regulation of myeloid leukocyte mediated immunity
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity.
has exact synonym: downregulation of myeloid leukocyte mediated immunity
has exact synonym: down regulation of myeloid leukocyte mediated immunity
has exact synonym: down-regulation of myeloid leukocyte mediated immunity
has related synonym: inhibition of myeloid leukocyte mediated immunity

positive regulation of myeloid leukocyte mediated immunity
type: Class
subclass of: positive regulation of leukocyte mediated immunity
subclass of: regulation of myeloid leukocyte mediated immunity
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity.
has related synonym: activation of myeloid leukocyte mediated immunity
has related synonym: stimulation of myeloid leukocyte mediated immunity
has exact synonym: upregulation of myeloid leukocyte mediated immunity
has exact synonym: up regulation of myeloid leukocyte mediated immunity
has exact synonym: up-regulation of myeloid leukocyte mediated immunity

regulation of immunoglobulin mediated immune response
type: Class
subclass of: regulation of B cell mediated immunity
IAO_0000115: Any process that modulates the frequency, rate, or extent of an immunoglobulin mediated immune response.

negative regulation of immunoglobulin mediated immune response
type: Class
subclass of: negative regulation of B cell mediated immunity
subclass of: regulation of immunoglobulin mediated immune response
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an immunoglobulin mediated immune response.
has exact synonym: downregulation of immunoglobulin mediated immune response
has exact synonym: down regulation of immunoglobulin mediated immune response
has exact synonym: down-regulation of immunoglobulin mediated immune response
has related synonym: inhibition of immunoglobulin mediated immune response

positive regulation of immunoglobulin mediated immune response
type: Class
subclass of: positive regulation of B cell mediated immunity
subclass of: regulation of immunoglobulin mediated immune response
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response.
has related synonym: activation of immunoglobulin mediated immune response
has related synonym: stimulation of immunoglobulin mediated immune response
has exact synonym: upregulation of immunoglobulin mediated immune response
has exact synonym: up regulation of immunoglobulin mediated immune response
has exact synonym: up-regulation of immunoglobulin mediated immune response

regulation of type II hypersensitivity
type: Class
subclass of: regulation of hypersensitivity
subclass of: regulation of myeloid leukocyte mediated immunity
subclass of: regulation of immunoglobulin mediated immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of type II hypersensitivity.

negative regulation of type II hypersensitivity
type: Class
subclass of: negative regulation of hypersensitivity
subclass of: negative regulation of myeloid leukocyte mediated immunity
subclass of: negative regulation of immunoglobulin mediated immune response
subclass of: regulation of type II hypersensitivity
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of type II hypersensitivity.
has exact synonym: downregulation of type II hypersensitivity
has exact synonym: down regulation of type II hypersensitivity
has exact synonym: down-regulation of type II hypersensitivity
has related synonym: inhibition of type II hypersensitivity

positive regulation of type II hypersensitivity
type: Class
subclass of: positive regulation of hypersensitivity
subclass of: positive regulation of myeloid leukocyte mediated immunity
subclass of: positive regulation of immunoglobulin mediated immune response
subclass of: regulation of type II hypersensitivity
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of type II hypersensitivity.
has related synonym: activation of type II hypersensitivity
has related synonym: stimulation of type II hypersensitivity
has exact synonym: upregulation of type II hypersensitivity
has exact synonym: up regulation of type II hypersensitivity
has exact synonym: up-regulation of type II hypersensitivity

regulation of central B cell tolerance induction
type: Class
subclass of: regulation of central tolerance induction
subclass of: regulation of B cell tolerance induction
IAO_0000115: Any process that modulates the frequency, rate, or extent of central B cell tolerance induction.

negative regulation of central B cell tolerance induction
type: Class
subclass of: negative regulation of central tolerance induction
subclass of: negative regulation of B cell tolerance induction
subclass of: regulation of central B cell tolerance induction
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell tolerance induction.
has exact synonym: downregulation of central B cell tolerance induction
has exact synonym: down regulation of central B cell tolerance induction
has exact synonym: down-regulation of central B cell tolerance induction
has related synonym: inhibition of central B cell tolerance induction

positive regulation of central B cell tolerance induction
type: Class
subclass of: positive regulation of central tolerance induction
subclass of: positive regulation of B cell tolerance induction
subclass of: regulation of central B cell tolerance induction
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of central B cell tolerance induction.
has related synonym: activation of central B cell tolerance induction
has related synonym: stimulation of central B cell tolerance induction
has exact synonym: upregulation of central B cell tolerance induction
has exact synonym: up regulation of central B cell tolerance induction
has exact synonym: up-regulation of central B cell tolerance induction

regulation of central B cell deletion
type: Class
subclass of: regulation of B cell deletion
subclass of: regulation of central B cell tolerance induction
subclass of: GO_0045577
IAO_0000115: Any process that modulates the frequency, rate, or extent of central B cell deletion.

negative regulation of central B cell deletion
type: Class
subclass of: negative regulation of B cell deletion
subclass of: negative regulation of central B cell tolerance induction
subclass of: regulation of central B cell deletion
subclass of: GO_0045578
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell deletion.
has exact synonym: downregulation of central B cell deletion
has exact synonym: down regulation of central B cell deletion
has exact synonym: down-regulation of central B cell deletion
has related synonym: inhibition of central B cell deletion

positive regulation of central B cell deletion
type: Class
subclass of: positive regulation of B cell deletion
subclass of: positive regulation of central B cell tolerance induction
subclass of: regulation of central B cell deletion
subclass of: GO_0045579
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of central B cell deletion.
has related synonym: activation of central B cell deletion
has related synonym: stimulation of central B cell deletion
has exact synonym: upregulation of central B cell deletion
has exact synonym: up regulation of central B cell deletion
has exact synonym: up-regulation of central B cell deletion

mature B cell apoptotic process
type: Class
subclass of: B cell apoptotic process
subclass of: part-of-parent-1782
IAO_0000115: Any apoptotic process in a B cell that is mature, having left the bone marrow.
has exact synonym: apoptosis of mature B cells
has exact synonym: apoptosis of mature B-cells
has exact synonym: apoptosis of mature B lymphocytes
has exact synonym: apoptosis of mature B-lymphocytes
has related synonym: mature B cell apoptosis
has exact synonym: mature B-cell apoptosis
has exact synonym: mature B cell programmed cell death by apoptosis
has exact synonym: mature B-cell programmed cell death by apoptosis
has exact synonym: mature B lymphocyte apoptosis
has exact synonym: mature B-lymphocyte apoptosis
has exact synonym: mature B lymphocyte programmed cell death by apoptosis
has exact synonym: mature B-lymphocyte programmed cell death by apoptosis
has exact synonym: programmed cell death, mature B cells
has exact synonym: programmed cell death, mature B-cells
has exact synonym: programmed cell death, mature B lymphocytes
has exact synonym: programmed cell death, mature B-lymphocytes
has exact synonym: programmed cell death of mature B cells by apoptosis
has exact synonym: programmed cell death of mature B-cells by apoptosis
has exact synonym: programmed cell death of mature B lymphocytes by apoptosis
has exact synonym: programmed cell death of mature B-lymphocytes by apoptosis

regulation of B cell apoptotic process
type: Class
subclass of: GO_0070228
IAO_0000115: Any process that modulates the frequency, rate, or extent of B cell apoptotic process.
has related synonym: regulation of B cell apoptosis

negative regulation of B cell apoptotic process
type: Class
subclass of: regulation of B cell apoptotic process
subclass of: GO_0070229
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process.
has exact synonym: downregulation of B cell apoptosis
has exact synonym: down regulation of B cell apoptosis
has exact synonym: down-regulation of B cell apoptosis
has related synonym: inhibition of B cell apoptosis
has related synonym: negative regulation of B cell apoptosis

positive regulation of B cell apoptotic process
type: Class
subclass of: regulation of B cell apoptotic process
subclass of: GO_0070230
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of B cell apoptotic process.
has related synonym: activation of B cell apoptosis
has related synonym: positive regulation of B cell apoptosis
has related synonym: stimulation of B cell apoptosis
has exact synonym: upregulation of B cell apoptosis
has exact synonym: up regulation of B cell apoptosis
has exact synonym: up-regulation of B cell apoptosis

regulation of mature B cell apoptotic process
type: Class
subclass of: regulation of immune system process
subclass of: regulation of B cell apoptotic process
IAO_0000115: Any process that modulates the frequency, rate, or extent of mature B cell apoptotic process.
has related synonym: regulation of mature B cell apoptosis

negative regulation of mature B cell apoptotic process
type: Class
subclass of: negative regulation of B cell apoptotic process
subclass of: regulation of mature B cell apoptotic process
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of mature B cell apoptotic process.
has exact synonym: downregulation of mature B cell apoptosis
has exact synonym: down regulation of mature B cell apoptosis
has exact synonym: down-regulation of mature B cell apoptosis
has related synonym: inhibition of mature B cell apoptosis
has related synonym: negative regulation of mature B cell apoptosis

positive regulation of mature B cell apoptotic process
type: Class
subclass of: positive regulation of immune system process
subclass of: positive regulation of B cell apoptotic process
subclass of: regulation of mature B cell apoptotic process
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of mature B cell apoptotic process.
has related synonym: activation of mature B cell apoptosis
has related synonym: positive regulation of mature B cell apoptosis
has related synonym: stimulation of mature B cell apoptosis
has exact synonym: upregulation of mature B cell apoptosis
has exact synonym: up regulation of mature B cell apoptosis
has exact synonym: up-regulation of mature B cell apoptosis

regulation of peripheral B cell deletion
type: Class
subclass of: regulation of peripheral tolerance induction
subclass of: regulation of B cell mediated immunity
subclass of: regulation of B cell deletion
IAO_0000115: Any process that modulates the frequency, rate, or extent of peripheral B cell deletion.

negative regulation of peripheral B cell deletion
type: Class
subclass of: negative regulation of peripheral tolerance induction
subclass of: negative regulation of B cell mediated immunity
subclass of: negative regulation of B cell deletion
subclass of: regulation of peripheral B cell deletion
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell deletion.
has exact synonym: downregulation of peripheral B cell deletion
has exact synonym: down regulation of peripheral B cell deletion
has exact synonym: down-regulation of peripheral B cell deletion
has related synonym: inhibition of peripheral B cell deletion

positive regulation of peripheral B cell deletion
type: Class
subclass of: positive regulation of peripheral tolerance induction
subclass of: positive regulation of B cell mediated immunity
subclass of: positive regulation of B cell deletion
subclass of: regulation of peripheral B cell deletion
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of peripheral B cell deletion.
has related synonym: activation of peripheral B cell deletion
has related synonym: stimulation of peripheral B cell deletion
has exact synonym: upregulation of peripheral B cell deletion
has exact synonym: up regulation of peripheral B cell deletion
has exact synonym: up-regulation of peripheral B cell deletion

regulation of lymphocyte anergy
type: Class
subclass of: regulation of tolerance induction
IAO_0000115: Any process that modulates the frequency, rate, or extent of lymphocyte anergy.

negative regulation of lymphocyte anergy
type: Class
subclass of: negative regulation of tolerance induction
subclass of: regulation of lymphocyte anergy
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte anergy.
has exact synonym: downregulation of lymphocyte anergy
has exact synonym: down regulation of lymphocyte anergy
has exact synonym: down-regulation of lymphocyte anergy
has related synonym: inhibition of lymphocyte anergy

positive regulation of lymphocyte anergy
type: Class
subclass of: positive regulation of tolerance induction
subclass of: regulation of lymphocyte anergy
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of lymphocyte anergy.
has related synonym: activation of lymphocyte anergy
has related synonym: stimulation of lymphocyte anergy
has exact synonym: upregulation of lymphocyte anergy
has exact synonym: up regulation of lymphocyte anergy
has exact synonym: up-regulation of lymphocyte anergy

regulation of central B cell anergy
type: Class
subclass of: regulation of B cell anergy
subclass of: regulation of central B cell tolerance induction
subclass of: GO_0045577
IAO_0000115: Any process that modulates the frequency, rate, or extent of central B cell anergy.

negative regulation of central B cell anergy
type: Class
subclass of: negative regulation of B cell anergy
subclass of: negative regulation of central B cell tolerance induction
subclass of: regulation of central B cell anergy
subclass of: GO_0045578
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell anergy.
has exact synonym: downregulation of central B cell anergy
has exact synonym: down regulation of central B cell anergy
has exact synonym: down-regulation of central B cell anergy
has related synonym: inhibition of central B cell anergy

positive regulation of central B cell anergy
type: Class
subclass of: positive regulation of B cell anergy
subclass of: positive regulation of central B cell tolerance induction
subclass of: regulation of central B cell anergy
subclass of: GO_0045579
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of central B cell anergy.
has related synonym: activation of central B cell anergy
has related synonym: stimulation of central B cell anergy
has exact synonym: upregulation of central B cell anergy
has exact synonym: up regulation of central B cell anergy
has exact synonym: up-regulation of central B cell anergy

regulation of peripheral B cell anergy
type: Class
subclass of: regulation of peripheral tolerance induction
subclass of: regulation of B cell anergy
subclass of: regulation of B cell mediated immunity
IAO_0000115: Any process that modulates the frequency, rate, or extent of peripheral B cell anergy.

negative regulation of peripheral B cell anergy
type: Class
subclass of: negative regulation of peripheral tolerance induction
subclass of: negative regulation of B cell anergy
subclass of: negative regulation of B cell mediated immunity
subclass of: regulation of peripheral B cell anergy
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell anergy.
has exact synonym: downregulation of peripheral B cell anergy
has exact synonym: down regulation of peripheral B cell anergy
has exact synonym: down-regulation of peripheral B cell anergy
has related synonym: inhibition of peripheral B cell anergy

positive regulation of peripheral B cell anergy
type: Class
subclass of: positive regulation of peripheral tolerance induction
subclass of: positive regulation of B cell anergy
subclass of: positive regulation of B cell mediated immunity
subclass of: regulation of peripheral B cell anergy
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of peripheral B cell anergy.
has related synonym: activation of peripheral B cell anergy
has related synonym: stimulation of peripheral B cell anergy
has exact synonym: upregulation of peripheral B cell anergy
has exact synonym: up regulation of peripheral B cell anergy
has exact synonym: up-regulation of peripheral B cell anergy

regulation of humoral immune response
type: Class
subclass of: GO_0050776
IAO_0000115: Any process that modulates the frequency, rate, or extent of a humoral immune response.

negative regulation of humoral immune response
type: Class
subclass of: regulation of humoral immune response
subclass of: GO_0050777
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response.
has exact synonym: downregulation of humoral immune response
has exact synonym: down regulation of humoral immune response
has exact synonym: down-regulation of humoral immune response
has related synonym: inhibition of humoral immune response

positive regulation of humoral immune response
type: Class
subclass of: regulation of humoral immune response
subclass of: GO_0050778
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a humoral immune response.
has related synonym: activation of humoral immune response
has related synonym: stimulation of humoral immune response
has exact synonym: upregulation of humoral immune response
has exact synonym: up regulation of humoral immune response
has exact synonym: up-regulation of humoral immune response

regulation of humoral immune response mediated by circulating immunoglobulin
type: Class
subclass of: regulation of immunoglobulin mediated immune response
subclass of: regulation of humoral immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin.

negative regulation of humoral immune response mediated by circulating immunoglobulin
type: Class
subclass of: negative regulation of immunoglobulin mediated immune response
subclass of: negative regulation of humoral immune response
subclass of: regulation of humoral immune response mediated by circulating immunoglobulin
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin.
has exact synonym: downregulation of humoral immune response mediated by circulating immunoglobulin
has exact synonym: down regulation of humoral immune response mediated by circulating immunoglobulin
has exact synonym: down-regulation of humoral immune response mediated by circulating immunoglobulin
has related synonym: inhibition of humoral immune response mediated by circulating immunoglobulin

positive regulation of humoral immune response mediated by circulating immunoglobulin
type: Class
subclass of: positive regulation of immunoglobulin mediated immune response
subclass of: positive regulation of humoral immune response
subclass of: regulation of humoral immune response mediated by circulating immunoglobulin
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin.
has related synonym: activation of humoral immune response mediated by circulating immunoglobulin
has related synonym: stimulation of humoral immune response mediated by circulating immunoglobulin
has exact synonym: upregulation of humoral immune response mediated by circulating immunoglobulin
has exact synonym: up regulation of humoral immune response mediated by circulating immunoglobulin
has exact synonym: up-regulation of humoral immune response mediated by circulating immunoglobulin

tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
type: Class
subclass of: tRNA wobble uridine modification
IAO_0000115: The process whereby a wobble base uridine residue in a tRNA is modified to 5-methoxycarbonylmethyl-2-thiouridine.
has exact synonym: mcm5 modification
has exact synonym: mcm5s2U34 biosynthesis
has exact synonym: tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis

archaeosine-tRNA biosynthetic process
type: Class
subclass of: GO_0006400
subclass of: GO_0009058
IAO_0000115: The chemical reactions and pathways involved in the biosynthesis of archaeosine, an archaea-specific modified base found at position 15 in the D-loop of certain archaeal tRNAs.

MECO complex
type: Class
subclass of: GO_0032991
IAO_0000115: A highly stable complex composed of the ATAC complex and the mediator complex (also called TRAP or MED). MECO binds and regulates the transcription of a subset of non-coding RNAs transcribed by RNA polymerase II.
has exact synonym: meta-coactivator complex

trabecular meshwork development
type: Class
subclass of: GO_0009888
subclass of: part-of-parent-43010
IAO_0000115: The progression of the trabecular meshwork over time, from its formation to the mature structure. The trabecular meshwork is a fenestrated endothelial-like tissue situated at the intersection of the cornea and the iris. The trabecular meshwork provides drainage for the aqueous humor.

response to ischemia
type: Class
subclass of: GO_0006950
IAO_0000115: Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.

tendon sheath development
type: Class
subclass of: GO_0061448
subclass of: part-of-parent-35989
IAO_0000115: The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move.

lipid hydroxylation
type: Class
subclass of: GO_0030258
IAO_0000115: The covalent attachment of a hydroxyl group to one or more fatty acids in a lipid.
has related synonym: fatty acid hydroxylation

desmosome organization
type: Class
subclass of: GO_0045216
IAO_0000115: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.

tRNA (adenine-C2-)-methyltransferase activity
type: Class
subclass of: GO_0008169
subclass of: GO_0016426
IAO_0000115: Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(37) in tRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + C2-methyladenine(37) in a tRNA.

bradykinin biosynthetic process
type: Class
subclass of: GO_0043043
IAO_0000115: The chemical reactions and pathways resulting in the formation of the peptide hormone bradykinin.

tRNA 4-thiouridine biosynthesis
type: Class
subclass of: GO_0034227
IAO_0000115: The processes whereby a uridine residue in a tRNA is converted to 4-thiouridine. Typically 4-thiouridine is found at position 8, in many transfer RNAs.

tRNA guanine ribose methylation
type: Class
subclass of: tRNA nucleoside ribose methylation
IAO_0000115: The process whereby a guanosine residue in a tRNA is methylated on the 2'-hydroxyl group of the ribose moiety.

tRNA N1-guanine methylation
type: Class
subclass of: GO_0030488
IAO_0000115: The process whereby a guanine in tRNA is methylated at position N1 of the guanine.
has related synonym: tRNA m1-guanine biosynthesis

tRNA N2-guanine methylation
type: Class
subclass of: GO_0030488
IAO_0000115: The process whereby a guanine in a tRNA is methylated at the N2 position of guanine.
has related synonym: tRNA m2-guanine biosynthesis

synoviocyte proliferation
type: Class
subclass of: GO_0050673
IAO_0000115: The multiplication or reproduction of type B synoviocytes by cell division, resulting in the expansion of their population. A type B synoviocyte is a fibroblast-like cell found in synovial tissues.

tRNA m2,2-guanine biosynthesis
type: Class
subclass of: GO_0030488
IAO_0000115: The process whereby a guanine residue in a transfer RNA is methylated twice at the N2 position.

tRNA dihydrouridine synthesis
type: Class
subclass of: GO_0006400
IAO_0000115: The process whereby a uridine in a transfer RNA is converted to dihydrouridine.

cyclin K-CDK12 complex
type: Class
subclass of: cyclin-dependent protein kinase holoenzyme complex
IAO_0000115: A protein complex consisting of cyclin Kand cyclin-dependent kinase 12 (CDK12). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
has related synonym: CycK/Cdk12 complex

cyclin K-CDK13 complex
type: Class
subclass of: cyclin-dependent protein kinase holoenzyme complex
IAO_0000115: A protein complex consisting of cyclin Kand cyclin-dependent kinase 13 (CDK13). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
has related synonym: CycK/Cdk13 complex

tRNA C5-cytosine methylation
type: Class
subclass of: GO_0030488
IAO_0000115: The process whereby a cytosine in a tRNA is methylated at position 5 of the cytosine.
has related synonym: tRNA 5-methylcytosine biosynthesis

tumor necrosis factor receptor superfamily complex
type: Class
subclass of: GO_0043235
IAO_0000115: A receptor complex that contains one or more members of the tumor necrosis factor (TNF) receptor superfamily.
has related synonym: TNF receptor superfamily complex

archaeosine synthase activity
type: Class
subclass of: GO_0016769
IAO_0000115: Catalysis of the reaction: L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O = L-glutamate + archaeine15 in tRNA.
has related synonym: ArcS
has related synonym: glutamine:preQ0-tRNA amidinotransferase

tRNA threonylcarbamoyladenosine modification
type: Class
subclass of: GO_0006400
subclass of: GO_0070525
IAO_0000115: The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base).
has exact synonym: t6A biosynthesis
has exact synonym: t6A biosynthetic process
has exact synonym: t6A tRNA modification
has exact synonym: threonylcarbamoyladenosine anabolism
has exact synonym: threonylcarbamoyladenosine biosynthesis
has exact synonym: threonylcarbamoyladenosine biosynthetic process
has exact synonym: threonylcarbamoyladenosine formation
has exact synonym: threonylcarbamoyladenosine synthesis
replaces: GO_0070526

ceramide phosphoethanolamine synthase activity
type: Class
subclass of: GO_0016780
IAO_0000115: Catalysis of the reaction: CDP-ethanolamine + a ceramide = CMP + a ceramide phosphoethanolamine.

leukotriene-C(4) hydrolase
type: Class
subclass of: GO_0008242
IAO_0000115: Catalysis of the reaction leukotriene C(4) + H(2)O= leukotriene D(4) + L-glutamate.

(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
type: Class
subclass of: GO_0016853
IAO_0000115: Catalysis of the reaction (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione = 3-hydroxy-5-phosphonooxypentane-2,4-dione.
has related synonym: phospho-AI-2 isomerase activity

5'-deoxynucleotidase activity
type: Class
subclass of: GO_0016791
IAO_0000115: Catalysis of the reaction:a 2'-deoxyribonucleoside 5'-monophosphate + H20=a 2'-deoxyribonucleoside + phosphate.

obsolete generation of a signal involved in cell-cell signaling
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The cellular process that creates a physical entity or change in state, i.e. a signal, that originates in one cell and is used to transfer information to another cell. This process begins with the initial formation of the signal and ends with the mature form and placement of the signal.

regionalization
type: Class
subclass of: GO_0007389
IAO_0000115: The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.
has related synonym: pattern formation

follicular fluid formation in ovarian follicle antrum involved in fused antrum stage
type: Class
subclass of: follicular fluid formation in ovarian follicle antrum
subclass of: part-of-parent-48165
IAO_0000115: The ovulation cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the fused antrum stage of oogenesis.
has related synonym: follicular fluid formation in ovarian follicle antrum during fused antrum stage

follicular fluid formation in ovarian follicle antrum involved in distinct antral spaces stage
type: Class
subclass of: follicular fluid formation in ovarian follicle antrum
subclass of: part-of-parent-48164
IAO_0000115: The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the antral spaces stage of oogenesis.
has related synonym: follicular fluid formation in ovarian follicle antrum during distinct antral spaces stage

follicular fluid formation in ovarian follicle antrum involved in scattered antral spaces stage
type: Class
subclass of: follicular fluid formation in ovarian follicle antrum
subclass of: part-of-parent-48163
IAO_0000115: The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the scattered antral spaces stage of oogenesis.
has related synonym: follicular fluid formation in ovarian follicle antrum during scattered antral spaces stage

developmental process involved in reproduction
type: Class
subclass of: GO_0022414
subclass of: GO_0032502
subclass of: part-of-parent-3
IAO_0000115: A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring.
has related synonym: puberty
has related synonym: reproductive developmental process

heart morphogenesis
type: Class
subclass of: GO_0009887
subclass of: part-of-parent-7507
IAO_0000115: The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
has related synonym: cardiac morphogenesis

system process
type: Class
subclass of: GO_0032501
IAO_0000115: A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.
has exact synonym: organ system process

skeletal muscle contraction
type: Class
subclass of: GO_0006941
subclass of: part-of-parent-50881
IAO_0000115: A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control.

voluntary skeletal muscle contraction
type: Class
subclass of: skeletal muscle contraction
IAO_0000115: A process in which force is generated within voluntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the voluntary skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and it is under voluntary control. Voluntary skeletal muscle is skeletal muscle that is under conscious control.

involuntary skeletal muscle contraction
type: Class
subclass of: skeletal muscle contraction
IAO_0000115: A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Involuntary skeletal muscle is skeletal muscle that is not under conscious control.

muscle system process
type: Class
subclass of: system process
IAO_0000115: A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.
has related synonym: muscle physiological process

circulatory system process
type: Class
subclass of: system process
IAO_0000115: A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.

renal system process
type: Class
subclass of: system process
IAO_0000115: A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila).
has exact synonym: excretory system process
has related synonym: kidney system process

heart process
type: Class
subclass of: circulatory system process
IAO_0000115: A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
has related synonym: cardiac process

respiratory system process
type: Class
subclass of: system process
subclass of: part-of-parent-7585
IAO_0000115: A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange.
has exact synonym: respiratory gaseous exchange
replaces: GO_0010802

lymph circulation
type: Class
subclass of: circulatory system process
IAO_0000115: The flow of lymph through the body of an animal.

vascular process in circulatory system
type: Class
subclass of: circulatory system process
IAO_0000115: A circulatory process that occurs at the level of the vasculature.
has exact synonym: vasculature process

central nervous system control of baroreceptor feedback
type: Class
subclass of: nervous system process involved in regulation of systemic arterial blood pressure
subclass of: part-of-parent-1978
IAO_0000115: The neurological process in which nerve impulses arising in the aorta or the carotid sinuses travel to the medulla and reach the nucleus of tractus solaris.

detection of reduced oxygen by chemoreceptor signaling
type: Class
subclass of: GO_0070483
subclass of: part-of-parent-2007
IAO_0000115: The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies.
has exact synonym: detection of reduced oxygen by chemoreceptor signalling

detection of increased carbon dioxide by chemoreceptor signaling
type: Class
subclass of: detection of carbon dioxide
subclass of: part-of-parent-2007
IAO_0000115: The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies.
has exact synonym: detection of increased carbon dioxide by chemoreceptor signalling

detection of pH by chemoreceptor signaling
type: Class
subclass of: detection of hydrogen ion
IAO_0000115: The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors.
has exact synonym: detection of pH by chemoreceptor signalling

baroreceptor detection of increased arterial stretch
type: Class
subclass of: baroreceptor detection of arterial stretch
subclass of: part-of-parent-1983
IAO_0000115: The series of events by which an increase in diameter of an artery is detected and converted to a molecular signal.

baroreceptor detection of decreased arterial stretch
type: Class
subclass of: baroreceptor detection of arterial stretch
subclass of: part-of-parent-1982
IAO_0000115: The series of events by which a decrease in diameter of an artery is detected and converted to a molecular signal.

regulation of systemic arterial blood pressure by baroreceptor feedback
type: Class
subclass of: nervous system process involved in regulation of systemic arterial blood pressure
IAO_0000115: The neural regulation of blood pressure in which baroreceptors sense the amount of stretch occurring in vessels and respond to the input via central nervous system control.
has exact synonym: baroreceptor regulation of systemic arterial blood pressure

regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback
type: Class
subclass of: nervous system process involved in regulation of systemic arterial blood pressure
subclass of: part-of-parent-3025
IAO_0000115: The process that modulates blood pressure by sensing the amount of stretch occurring in the aorta and responding to the input via central nervous system control.
has exact synonym: aortic arch baroreceptor control of systemic arterial blood pressure

regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling
type: Class
subclass of: regulation of systemic arterial blood pressure by chemoreceptor signaling
IAO_0000115: The process that modulates blood pressure by the action of chemoreceptors found in the carotid bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions.
has exact synonym: carotid body chemoreceptor regulation of systemic arterial blood pressure
has exact synonym: carotid body chemoreceptor response to lowering of systemic arterial blood pressure
has exact synonym: regulation of systemic arterial blood pressure by carotid body chemoreceptor signalling
has related synonym: vagal reflex

regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling
type: Class
subclass of: regulation of systemic arterial blood pressure by chemoreceptor signaling
IAO_0000115: The process that modulates blood pressure by the action of chemoreceptors found in the aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions.
has exact synonym: aortic body chemoreceptor regulation of systemic arterial blood pressure
has exact synonym: aortic body chemoreceptor response to lowering of systemic arterial blood pressure
has exact synonym: regulation of systemic arterial blood pressure by aortic body chemoreceptor signalling

detection of hypoxic conditions in blood by carotid body chemoreceptor signaling
type: Class
subclass of: detection of hypoxic conditions in blood by chemoreceptor signaling
subclass of: part-of-parent-3027
IAO_0000115: The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies.
has exact synonym: detection of hypoxic conditions in blood by carotid body chemoreceptor signalling

detection of hydrogen ion
type: Class
subclass of: GO_0009593
IAO_0000115: The series of events in which a hydrogen ion stimulus is received by a cell and converted into a molecular signal.

detection of carbon dioxide
type: Class
subclass of: GO_0009593
IAO_0000115: The series of events in which a carbon dioxide stimulus is received by a cell and converted into a molecular signal.

detection of oxygen
type: Class
subclass of: GO_0009593
subclass of: GO_0070482
IAO_0000115: The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal.

detection of hypoxic conditions in blood by aortic body chemoreceptor signaling
type: Class
subclass of: detection of hypoxic conditions in blood by chemoreceptor signaling
subclass of: part-of-parent-3028
IAO_0000115: The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the aortic bodies.
has exact synonym: detection of hypoxic conditions in blood by aortic body chemoreceptor signalling

detection of increased carbon dioxide by aortic body chemoreceptor signaling
type: Class
subclass of: detection of increased carbon dioxide by chemoreceptor signaling
subclass of: part-of-parent-3033
IAO_0000115: The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in an aortic body.
has exact synonym: detection of increased carbon dioxide by aortic body chemoreceptor signalling

detection of increased carbon dioxide by carotid body chemoreceptor signaling
type: Class
subclass of: detection of increased carbon dioxide by chemoreceptor signaling
subclass of: part-of-parent-3029
IAO_0000115: The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in a carotid body.
has exact synonym: detection of increased carbon dioxide by carotid body chemoreceptor signalling

detection of pH by aortic body chemoreceptor signaling
type: Class
subclass of: detection of pH by chemoreceptor signaling
subclass of: part-of-parent-3033
IAO_0000115: The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in an aortic body.
has exact synonym: detection of pH by aortic body chemoreceptor signalling

detection of pH by carotid body chemoreceptor signaling
type: Class
subclass of: detection of pH by chemoreceptor signaling
subclass of: part-of-parent-3029
IAO_0000115: The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in a carotid body.
has exact synonym: detection of pH by carotid body chemoreceptor signalling

detection of reduced oxygen by aortic body chemoreceptor signaling
type: Class
subclass of: detection of reduced oxygen by chemoreceptor signaling
subclass of: part-of-parent-3033
IAO_0000115: The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in an aortic body.
has exact synonym: detection of reduced oxygen by aortic body chemoreceptor signalling

detection of reduced oxygen by carotid body chemoreceptor signaling
type: Class
subclass of: detection of reduced oxygen by chemoreceptor signaling
subclass of: part-of-parent-3029
IAO_0000115: The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in a carotid body.
has exact synonym: detection of reduced oxygen by carotid body chemoreceptor signalling

excitation of vasomotor center by aortic body chemoreceptor signaling
type: Class
subclass of: excitation of vasomotor center by chemoreceptor signaling
subclass of: part-of-parent-3028
IAO_0000115: The process in which the molecular signal from an aortic body is relayed to the vasomotor center, causing it to signal an increase arterial pressure.
has exact synonym: excitation of vasomotor center by aortic body chemoreceptor signalling

excitation of vasomotor center by carotid body chemoreceptor signaling
type: Class
subclass of: excitation of vasomotor center by chemoreceptor signaling
subclass of: part-of-parent-3027
IAO_0000115: The process in which the molecular signal from a carotid body is relayed to the vasomotor center, causing it to signal an increase arterial pressure.
has exact synonym: excitation of vasomotor center by carotid body chemoreceptor signalling

vasoconstriction of artery involved in carotid body chemoreceptor response to lowering of systemic arterial blood pressure
type: Class
subclass of: vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure
subclass of: part-of-parent-3027
IAO_0000115: A process that is triggered by carotid body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure.
has related synonym: vasoconstriction of artery during carotid body chemoreceptor response to lowering of systemic arterial blood pressure

vasoconstriction of artery involved in aortic body chemoreceptor response to lowering of systemic arterial blood pressure
type: Class
subclass of: vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure
subclass of: part-of-parent-3028
IAO_0000115: A process that is triggered by aortic body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure.
has related synonym: vasoconstriction of artery during aortic body chemoreceptor response to lowering of systemic arterial blood pressure

regulation of systemic arterial blood pressure mediated by a chemical signal
type: Class
subclass of: regulation of systemic arterial blood pressure
IAO_0000115: The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine.
has exact synonym: blood pressure regulation mediated by a chemical signal

regulation of systemic arterial blood pressure by physical factors
type: Class
subclass of: regulation of systemic arterial blood pressure
IAO_0000115: The regulation of blood pressure mediated by detection of forces within the circulatory system.
has exact synonym: blood pressure regulation by physical factors

regulation of systemic arterial blood pressure by stress relaxation
type: Class
subclass of: regulation of systemic arterial blood pressure by physical factors
subclass of: negative regulation of systemic arterial blood pressure
IAO_0000115: The intrinsic circulatory process resulting from stress relaxation that modulates the force with which blood travels through the systemic arterial circulatory system. Stress relaxation is the adaptation of vessels to a new size as a result of changes in pressure in storage areas such as veins, the liver, the spleen, and the lungs.
has exact synonym: blood pressure regulation by stress relaxation

regulation of systemic arterial blood pressure by epinephrine
type: Class
subclass of: regulation of systemic arterial blood pressure mediated by a chemical signal
subclass of: part-of-parent-1993
IAO_0000115: The regulation of blood pressure mediated by the catecholamine signaling molecule epinephrine.
has related synonym: blood pressure regulation by epinephrine
has exact synonym: regulation of blood pressure by adrenaline

regulation of systemic arterial blood pressure by norepinephrine
type: Class
subclass of: regulation of systemic arterial blood pressure mediated by a chemical signal
subclass of: part-of-parent-1993
IAO_0000115: The regulation of blood pressure mediated by the catecholamine signaling molecule norepinephrine.
has related synonym: blood pressure regulation by norepinephrine
has exact synonym: regulation of blood pressure by noradrenaline

regulation of systemic arterial blood pressure by capillary fluid shift
type: Class
subclass of: regulation of systemic arterial blood pressure by physical factors
IAO_0000115: The intrinsic circulatory process resulting from capillary fluid shift that modulates the force with which blood travels through the systemic arterial circulatory system. Capillary fluid shift is the movement of fluid across the capillary membrane between the blood and the interstitial fluid compartment.
has exact synonym: blood pressure regulation by capillary fluid shift

regulation of systemic arterial blood pressure by atrial natriuretic peptide
type: Class
subclass of: regulation of systemic arterial blood pressure by hormone
IAO_0000115: The regulation of blood pressure mediated by the signaling molecule atrial natriuretic peptide.
has related synonym: blood pressure regulation by ANP
has exact synonym: blood pressure regulation by atrial natriuretic peptide

angiotensin-mediated drinking behavior
type: Class
subclass of: GO_0042756
subclass of: part-of-parent-2035
IAO_0000115: The drinking behavior that is mediated by the action of angiotensin in the brain. Angiotensin stimulates the brain centers that control thirst.
has exact synonym: angiotensin mediated drinking behavior

circadian regulation of systemic arterial blood pressure
type: Class
subclass of: regulation of systemic arterial blood pressure
subclass of: GO_0007623
IAO_0000115: Any process in which an organism modulates its blood pressure at different values with a regularity of approximately 24 hours.

circadian regulation of heart rate
type: Class
subclass of: regulation of heart rate
subclass of: GO_0007623
subclass of: GO_0032501
IAO_0000115: Any process in which an organism modulates its heart rate at different values with a regularity of approximately 24 hours.
has related synonym: circadian regulation of heart contraction rate

circadian regulation of systemic arterial blood pressure by the suprachiasmatic nucleus
type: Class
subclass of: nervous system process involved in regulation of systemic arterial blood pressure
subclass of: circadian regulation of systemic arterial blood pressure
IAO_0000115: The process in which the suprachiasmatic nucleus modulates blood pressure at different values with a regularity of approximately 24 hours.
has exact synonym: master pacemaker clock regulation of blood pressure
has exact synonym: SCN regulation of blood pressure

circadian regulation of heart rate by the suprachiasmatic nucleus
type: Class
subclass of: circadian regulation of heart rate
IAO_0000115: The process in which the suprachiasmatic nucleus modulates heart rate at different values with a regularity of approximately 24 hours.
has related synonym: circadian regulation of heart contraction rate by the suprachiasmatic nucleus
has exact synonym: master pacemaker clock regulation of heart rate
has exact synonym: SCN regulation of heart rate

regulation of vascular associated smooth muscle contraction
type: Class
subclass of: GO_0006940
subclass of: GO_0019229
IAO_0000115: Any process that increases the frequency, rate or extent of vascular smooth muscle contraction.
has exact synonym: regulation of vascular smooth muscle contraction

regulation of the force of heart contraction by chemical signal
type: Class
subclass of: regulation of the force of heart contraction
IAO_0000115: The regulation of the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine.
has exact synonym: chemical cardiac inotropy
has related synonym: regulation of the force of heart muscle contraction by chemical signal

hormonal regulation of the force of heart contraction
type: Class
subclass of: regulation of the force of heart contraction by chemical signal
IAO_0000115: The process in which the hormones modulates the force of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.
has exact synonym: hormonal cardiac inotropy
has related synonym: hormonal regulation of the force of heart muscle contraction

positive regulation of the force of heart contraction by epinephrine
type: Class
subclass of: positive regulation of the force of heart contraction by chemical signal
subclass of: part-of-parent-1997
IAO_0000115: The process in which the secretion of epinephrine into the bloodstream or released from nerve endings modulates the force of heart muscle contraction.
has exact synonym: adrenaline cardiac inotropy
has exact synonym: adrenaline regulation of the strength of heart muscle contraction
has exact synonym: epinephrine cardiac inotropy
has exact synonym: increased force of heart contraction by epinephrine
has related synonym: positive regulation of heart contraction by adrenaline
has related synonym: positive regulation of heart contraction by epinephrine

negative regulation of the force of heart contraction by acetylcholine
type: Class
subclass of: negative regulation of the force of heart contraction by chemical signal
subclass of: part-of-parent-3068
IAO_0000115: The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors and decreases the force of heart muscle contraction.
has exact synonym: decreased force of heart contraction by acetylcholine

positive regulation of the force of heart contraction by norepinephrine
type: Class
subclass of: positive regulation of the force of heart contraction by chemical signal
subclass of: part-of-parent-1997
IAO_0000115: The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings modulates the force of heart musclecontraction.
has related synonym: increased force of heart contraction by adrenaline
has exact synonym: increased force of heart contraction by norepinephrine
has exact synonym: noradrenaline cardiac inotropy
has exact synonym: noradrenaline regulation of the strength of heart muscle contraction
has exact synonym: norepinephrine cardiac inotropy
has related synonym: positive regulation of heart contraction by adrenaline
has related synonym: positive regulation of heart contraction by norepinephrine

regulation of heart rate by chemical signal
type: Class
subclass of: regulation of heart rate
IAO_0000115: The regulation of the rate of heart contraction mediated by chemical signaling, hormonal, autocrine or paracrine.
has exact synonym: chemical cardiac chronotropy
has related synonym: chemical signal regulation of heart contraction rate
has exact synonym: chemical signal regulation of heart rate

negative regulation of heart rate by acetylcholine
type: Class
subclass of: regulation of heart rate by chemical signal
subclass of: GO_0010459
subclass of: part-of-parent-3068
IAO_0000115: The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors on the pacemaker cells and decreases the rate of heart muscle contraction.
has related synonym: negative regulation of heart contraction rate by acetylcholine

regulation of heart rate by hormone
type: Class
subclass of: regulation of heart rate by chemical signal
IAO_0000115: The process in which the hormones modulates the rate of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.
has exact synonym: hormonal cardiac chronotropy
has exact synonym: regulation of the rate of heart contraction by hormone

positive regulation of heart rate by epinephrine
type: Class
subclass of: regulation of heart rate by chemical signal
subclass of: GO_0010460
subclass of: part-of-parent-1996
IAO_0000115: The process in which the secretion of epinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction.
has exact synonym: adrenaline cardiac chronotropy
has exact synonym: adrenaline regulation of the rate of heart muscle contraction
has exact synonym: epinephrine cardiac chronotropy
has related synonym: positive regulation of heart contraction rate by epinephrine
has related synonym: positive regulation of heart rate by adrenaline

positive regulation of heart rate by norepinephrine
type: Class
subclass of: regulation of heart rate by chemical signal
subclass of: GO_0010460
subclass of: part-of-parent-1996
IAO_0000115: The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction.
has exact synonym: noradrenaline cardiac chronotropy
has exact synonym: noradrenaline regulation of the rate of heart muscle contraction
has exact synonym: norepinephrine cardiac chronotropy
has related synonym: positive regulation of heart contraction rate by norepinephrine
has exact synonym: positive regulation of heart rate by adrenaline

circadian regulation of systemic arterial blood pressure by hormone
type: Class
subclass of: regulation of systemic arterial blood pressure by hormone
subclass of: part-of-parent-3052
IAO_0000115: The process in which hormones modulate the force with which blood passes through the circulatory system contributing to different values of blood pressure oscillating with a regularity of approximately 24 hours. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.

regulation of systemic arterial blood pressure by acetylcholine
type: Class
subclass of: regulation of systemic arterial blood pressure by neurotransmitter
IAO_0000115: The regulation of blood pressure mediated by acetylcholine signaling. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter.
has exact synonym: blood pressure regulation by acetylcholine

acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure
type: Class
subclass of: negative regulation of systemic arterial blood pressure
subclass of: GO_0042311
subclass of: part-of-parent-3068
IAO_0000115: The process in which acetylcholine signaling causes vasodilation, resulting in a change in blood pressure.
has exact synonym: vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure

regulation of systemic arterial blood pressure by neurotransmitter
type: Class
subclass of: nervous system process involved in regulation of systemic arterial blood pressure
subclass of: regulation of systemic arterial blood pressure mediated by a chemical signal
IAO_0000115: The regulation of blood pressure mediated by a neurotransmitter. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.

renal system process involved in regulation of systemic arterial blood pressure
type: Class
subclass of: renal system process
subclass of: part-of-parent-3073
IAO_0000115: Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
has exact synonym: renal control of blood pressure
has exact synonym: renal regulation of systemic arterial blood pressure

renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure
type: Class
subclass of: renal system process involved in regulation of systemic arterial blood pressure
IAO_0000115: The renal process that modulates the force with which blood travels through the circulatory system, by impeding blood flow through the peripheral vasculature.
has exact synonym: regulation of systemic arterial blood pressure by renal control of peripheral vascular resistence
has exact synonym: renal regulation of systemic arterial blood pressure by control of peripheral vascular resistence

regulation of systemic arterial blood pressure
type: Class
subclass of: GO_0008217
IAO_0000115: The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.

obsolete regulation of diuresis
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any process that modulates the rate of diuresis. Diuresis is the process of renal water excretion.

renal vasodilation of the peripheral vascular system involved in regulation of systemic arterial blood pressure
type: Class
subclass of: renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure
IAO_0000115: The renal process that modulates the force with which blood travels through the circulatory system, by vasodilation of the peripheral vascular system.
has exact synonym: renal regulation of systemic arterial blood pressure by vasodilation of the peripheral vascular system

obsolete negative regulation of diuresis
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any process that reduces the rate of diuresis. Diuresis is the process of renal water excretion.

obsolete regulation of natriuresis
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any process that modulates the frequency, rate, or extent of natriuresis, the process of renal sodium excretion.

obsolete positive regulation of natriuresis
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any process that activates or increases the frequency, rate or extent of natriuresis.

obsolete negative regulation of natriuresis
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any process that stops, prevents, or decreases the frequency, rate, or extent of natriuresis, the process of renal sodium excretion.

regulation of systemic arterial blood pressure by renin-angiotensin
type: Class
subclass of: regulation of systemic arterial blood pressure by hormone
IAO_0000115: The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system.
has exact synonym: blood pressure regulation by renin-angiotensin

obsolete positive regulation of renal output by angiotensin
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any process in which angiotensin directly increases the rate of natriuresis and diuresis in the kidney.

negative regulation of renal output by angiotensin
type: Class
subclass of: regulation of renal output by angiotensin
subclass of: positive regulation of systemic arterial blood pressure
IAO_0000115: The process in which angiotensin directly decreases the rate of natriuresis and diuresis in the kidney.
has exact synonym: angiotensin mediated negative regulation of renal output
has exact synonym: angiotensin-mediated negative regulation of renal output

positive regulation of systemic arterial blood pressure
type: Class
subclass of: GO_0045777
subclass of: part-of-parent-3073
IAO_0000115: The process that increases the force with which blood travels through the systemic arterial circulatory system.

negative regulation of systemic arterial blood pressure
type: Class
subclass of: GO_0045776
subclass of: part-of-parent-3073
IAO_0000115: The process that reduces the force with which blood travels through the systemic arterial circulatory system.

regulation of systemic arterial blood pressure by local renal renin-angiotensin
type: Class
subclass of: regulation of systemic arterial blood pressure by renin-angiotensin
IAO_0000115: The process in which angiotensinogen metabolites in the kidney modulate the force with which blood passes through the renal circulatory system. The process begins when renin cleaves angiotensinogen.

positive regulation of the force of heart contraction by neuronal epinephrine
type: Class
subclass of: positive regulation of the force of heart contraction by epinephrine
subclass of: part-of-parent-3090
IAO_0000115: The process in which the release of epinephrine from nerve endings modulates the force of heart muscle contraction.
has exact synonym: increased force of heart contraction by epinephrine released from the nerve endings
has related synonym: increased force of heart contraction by neuronal adrenaline
has exact synonym: increased force of heart contraction by neuronal epinephrine
has related synonym: positive regulation of heart contraction by adrenaline
has related synonym: positive regulation of heart contraction by neuronal epinephrine

positive regulation of the force of heart contraction by circulating epinephrine
type: Class
subclass of: positive regulation of the force of heart contraction by epinephrine
subclass of: part-of-parent-3089
IAO_0000115: The process in which the secretion of epinephrine into the bloodstream modulates the force of heart muscle contraction.
has related synonym: increased force of heart contraction by circulating adrenaline
has exact synonym: increased force of heart contraction by epinephrine in the bloodstream
has related synonym: positive regulation of heart contraction by circulating adrenaline
has related synonym: positive regulation of heart contraction by circulating epinephrine

positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine
type: Class
subclass of: positive regulation of the force of heart contraction by epinephrine-norepinephrine
IAO_0000115: Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream.
has exact synonym: increased force of heart contraction by circulating adrenaline-noradrenaline
has exact synonym: increased force of heart contraction by circulating epinephrine-norepinephrine
has exact synonym: increased force of heart contraction by epinephrine-norepinephrine in the blood stream
has related synonym: positive regulation of heart contraction by circulating adrenaline-noradrenaline
has related synonym: positive regulation of heart contraction by circulating epinephrine-norepinephrine

positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine
type: Class
subclass of: positive regulation of the force of heart contraction by epinephrine-norepinephrine
IAO_0000115: Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine released from the nerve endings.
has exact synonym: increased force of heart contraction by epinephrine-norepinephrine released from the nerve endings
has exact synonym: increased force of heart contraction by neuronal adrenaline-noradrenaline
has exact synonym: increased force of heart contraction by neuronal epinephrine-norepinephrine
has related synonym: positive regulation of heart contraction by adrenaline-noradrenaline
has related synonym: positive regulation of heart contraction by epinephrine-norepinephrine

renal water homeostasis
type: Class
subclass of: renal system process
subclass of: GO_0050891
IAO_0000115: Renal process involved in the maintenance of an internal steady state of water in the body.
has exact synonym: water homeostasis by the renal system

renal water retention
type: Class
subclass of: GO_0035811
IAO_0000115: The process in which renal water excretion is decreased.
has exact synonym: negative regulation of renal water excretion

regulation of glomerular filtration
type: Class
subclass of: renal system process involved in regulation of blood volume
subclass of: GO_0098801
IAO_0000115: Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule.

glomerular filtration
type: Class
subclass of: GO_0097205
IAO_0000115: The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein.

pressure natriuresis
type: Class
subclass of: renal system process involved in regulation of blood volume
IAO_0000115: The process in which the volume of blood increases renal pressure and thereby results in both an increase in urine volume (diuresis) and an increase in the amount of sodium excreted in the urine (natriuresis).

renal sodium ion transport
type: Class
subclass of: renal system process
subclass of: GO_0006814
IAO_0000115: The directed movement of sodium ions (Na+) by the renal system.

renal water transport
type: Class
subclass of: renal system process
subclass of: GO_0006833
subclass of: part-of-parent-3091
IAO_0000115: The directed movement of water (H2O) by the renal system.

tubuloglomerular feedback
type: Class
subclass of: renal system process involved in regulation of blood volume
subclass of: part-of-parent-3093
IAO_0000115: The process in which blood volume is regulated due to a change in the rate of glomerular filtration. This is accomplished by a feedback mechanism that senses changes in the juxtaglomerular apparatus.

positive regulation of the force of heart contraction by chemical signal
type: Class
subclass of: regulation of the force of heart contraction by chemical signal
subclass of: GO_0045823
IAO_0000115: Any process which increases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine.
has exact synonym: positive regulation of the force of heart muscle contraction by chemical signal

regulation of systemic arterial blood pressure by endothelin
type: Class
subclass of: regulation of systemic arterial blood pressure by hormone
IAO_0000115: The process in which endothelin modulates the force with which blood passes through the circulatory system. Endothelin is a hormone that is released by the endothelium, and it is a vasoconstrictor.

regulation of systemic arterial blood pressure by circulatory epinephrine-norepinephrine
type: Class
subclass of: regulation of systemic arterial blood pressure by hormone
IAO_0000115: The process in which epinephrine-norepinephrine modulate the force with which blood passes through the circulatory system.
has related synonym: regulation of blood pressure by circulating adrenaline-noradrenaline

obsolete positive regulation of diuresis by angiotensin
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any process mediated by angiotensin that increases the rate of diuresis.

obsolete positive regulation of diuresis
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any process that activates or increases the frequency, rate or extent of diuresis. Diuresis is the process of renal water excretion.

positive regulation of glomerular filtration
type: Class
subclass of: regulation of glomerular filtration
subclass of: GO_0051240
IAO_0000115: Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule.

negative regulation of glomerular filtration
type: Class
subclass of: regulation of glomerular filtration
subclass of: GO_0051241
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule.

negative regulation of glomerular filtration by angiotensin
type: Class
subclass of: negative regulation of renal output by angiotensin
subclass of: part-of-parent-3105
IAO_0000115: The process in which angiotensin directly decreases the rate of glomerular filtration in the kidney. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule.
has related synonym: angiotensin-mediated regulation of glomerular filtration
has related synonym: regulation of glomerular filtration by angiotensin

obsolete positive regulation of natriuresis by angiotensin
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The process in which angiotensin increases the rate of natriuresis indirectly via diuresis. Natriuresis is the process of renal sodium excretion.

negative regulation of the force of heart contraction by chemical signal
type: Class
subclass of: regulation of the force of heart contraction by chemical signal
subclass of: GO_0045822
IAO_0000115: Any process which decreases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine.
has related synonym: negative regulation of the force of heart muscle contraction by chemical signal

positive regulation of the force of heart contraction by circulating norepinephrine
type: Class
subclass of: positive regulation of the force of heart contraction by norepinephrine
IAO_0000115: The process in which the secretion of norepinephrine into the bloodstream modulates the force of heart muscle contraction.
has related synonym: increased force of heart contraction by circulating noradrenaline
has exact synonym: increased force of heart contraction by circulating norepinephrine

positive regulation of the force of heart contraction by neuronal norepinephrine
type: Class
subclass of: positive regulation of the force of heart contraction by norepinephrine
IAO_0000115: The process in which the release of norepinephrine from nerve endings modulates the force of heart muscle contraction.
has related synonym: increased force of heart contraction by neuronal noradrenaline
has exact synonym: increased force of heart contraction by neuronal norepinephrine

positive regulation of heart rate by circulating epinephrine
type: Class
subclass of: positive regulation of heart rate by epinephrine
IAO_0000115: The process in which the secretion of epinephrine into the bloodstream increases the rate of heart muscle contraction.
has exact synonym: positive regulation of heart rate by circulating adrenaline

positive regulation of heart rate by neuronal epinephrine
type: Class
subclass of: positive regulation of heart rate by epinephrine
IAO_0000115: The process in which the secretion of epinephrine from nerve endings increases the rate of heart muscle contraction.
has exact synonym: positive regulation of heart rate by neuronal adrenaline

positive regulation of heart rate by neuronal norepinephrine
type: Class
subclass of: positive regulation of heart rate by norepinephrine
IAO_0000115: The process in which the secretion of norepinephrine released from nerve endings increases the rate of heart muscle contraction.
has exact synonym: positive regulation of heart rate by neuronal noradrenaline

positive regulation of heart rate by circulating norepinephrine
type: Class
subclass of: positive regulation of heart rate by norepinephrine
IAO_0000115: The process in which the secretion of norepinephrine into the bloodstream increases the rate of heart muscle contraction.
has exact synonym: positive regulation of heart rate by circulating noradrenaline

regulation of vasoconstriction by epinephrine
type: Class
subclass of: GO_0019229
IAO_0000115: Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream or released by nerve endings.

regulation of vasoconstriction by norepinephrine
type: Class
subclass of: GO_0019229
IAO_0000115: Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream or released by nerve endings.

regulation of vasoconstriction by circulating norepinephrine
type: Class
subclass of: regulation of vasoconstriction by norepinephrine
IAO_0000115: Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream.
has exact synonym: regulation of vasoconstriction by circulating noradrenaline

regulation of vasoconstriction by neuronal norepinephrine
type: Class
subclass of: regulation of vasoconstriction by norepinephrine
IAO_0000115: Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of norepinephrine released by nerve endings.
has exact synonym: regulation of vasoconstriction by neuronal noradrenaline

regulation of vasoconstriction by neuronal epinephrine
type: Class
subclass of: regulation of vasoconstriction by epinephrine
IAO_0000115: Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of epinephrine released by nerve endings.
has exact synonym: regulation of vasoconstriction by neuronal adrenaline

regulation of vasoconstriction by circulating epinephrine
type: Class
subclass of: regulation of vasoconstriction by epinephrine
IAO_0000115: Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream.
has exact synonym: regulation of vasoconstriction by circulating adrenaline

epinephrine-mediated vasodilation
type: Class
subclass of: GO_0042311
IAO_0000115: A vasodilation process resulting from secretion of epinephrine into the bloodstream or released by nerve endings.
has related synonym: regulation of vasodilation by adrenaline
has related synonym: regulation of vasodilation by circulating adrenaline
has related synonym: regulation of vasodilation by circulating epinephrine
has related synonym: regulation of vasodilation by epinephrine
has related synonym: regulation of vasodilation by neuronal adrenaline
has related synonym: regulation of vasodilation by neuronal epinephrine
replaces: GO_0003123
replaces: GO_0003124

norepinephrine-mediated vasodilation
type: Class
subclass of: GO_0042311
IAO_0000115: A vasodilation process resulting from secretion of norepinephrine into the bloodstream or released by nerve endings.
has related synonym: regulation of vasodilation by circulating noradrenaline
has related synonym: regulation of vasodilation by circulating norepinephrine
has related synonym: regulation of vasodilation by neuronal noradrenaline
has related synonym: regulation of vasodilation by neuronal norepinephrine
has related synonym: regulation of vasodilation by noradrenaline
has related synonym: regulation of vasodilation by norepinephrine
replaces: GO_0003125
replaces: GO_0003126

detection of nodal flow
type: Class
subclass of: GO_0009726
subclass of: part-of-parent-7368
IAO_0000115: The series of events by which an endogenous stimulus is received by a cilium on a cell and converted to a molecular signal contributing to left/right asymmetry.

heart field specification
type: Class
subclass of: GO_0010092
subclass of: part-of-parent-60914
IAO_0000115: The process that results in the delineation of a specific region of the lateral mesoderm into the area in which the heart will develop.

heart induction
type: Class
subclass of: organ induction
subclass of: GO_2000826
IAO_0000115: The close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart.

BMP signaling pathway involved in heart induction
type: Class
subclass of: GO_0030509
subclass of: GO_1905114
subclass of: part-of-parent-3129
subclass of: part-of-parent-3134
IAO_0000115: The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to heart induction.
has exact synonym: BMP signalling pathway involved in heart induction

mesodermal-endodermal cell signaling
type: Class
subclass of: GO_0007267
IAO_0000115: Any process that mediates the transfer of information from mesodermal cells to endodermal cells.
has exact synonym: mesodermal-endodermal cell signalling

mesodermal-endodermal cell signaling involved in heart induction
type: Class
subclass of: mesodermal-endodermal cell signaling
subclass of: part-of-parent-3129
IAO_0000115: Any process that mediates the transfer of information from mesodermal cells to endodermal cells that contributes to heart induction.
has exact synonym: mesodermal-endodermal cell signalling involved in heart induction

endodermal-mesodermal cell signaling
type: Class
subclass of: GO_0007267
IAO_0000115: Any process that mediates the transfer of information from endodermal cells to mesodermal cells.
has exact synonym: endodermal-mesodermal cell signalling

endodermal-mesodermal cell signaling involved in heart induction
type: Class
subclass of: endodermal-mesodermal cell signaling
subclass of: part-of-parent-3129
IAO_0000115: Any process that mediates the transfer of information from endodermal cells to mesodermal cells that contributes to heart induction.
has exact synonym: endodermal-mesodermal cell signalling involved in heart induction

fibroblast growth factor receptor signaling pathway involved in heart induction
type: Class
subclass of: GO_0008543
subclass of: part-of-parent-3129
IAO_0000115: The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to heart induction.
has exact synonym: fibroblast growth factor receptor signalling pathway involved in heart induction

negative regulation of heart induction by canonical Wnt signaling pathway
type: Class
subclass of: GO_0009997
subclass of: GO_0061316
subclass of: GO_0100012
subclass of: GO_1901320
IAO_0000115: Any canonical Wnt signaling that decreases the rate, frequency or extent of heart induction.
has exact synonym: negative regulation of cardioblast cell fate specification by Wnt receptor signaling pathway
has exact synonym: negative regulation of heart induction by canonical Wnt-activated signaling pathway
has exact synonym: negative regulation of heart induction by canonical Wnt receptor signaling pathway
has exact synonym: negative regulation of heart induction by canonical Wnt receptor signalling pathway

Notch signaling pathway involved in heart induction
type: Class
subclass of: GO_0007219
subclass of: part-of-parent-3129
IAO_0000115: The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction.
has exact synonym: Notch signalling pathway involved in heart induction

primary heart field specification
type: Class
subclass of: heart field specification
IAO_0000115: The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle.
has exact synonym: FHS specification
has exact synonym: first heart field specification

secondary heart field specification
type: Class
subclass of: heart field specification
IAO_0000115: The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract).
has related synonym: anterior heart field specification
has exact synonym: second heart field specification
has exact synonym: SHF specification

determination of left/right asymmetry in lateral mesoderm
type: Class
subclass of: GO_0007368
subclass of: part-of-parent-48368
IAO_0000115: The establishment of the lateral mesoderm with respect to the left and right halves.

obsolete transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to lateral mesoderm left/right asymmetry determination.

cardiogenic plate morphogenesis
type: Class
subclass of: GO_0009653
subclass of: part-of-parent-3007
IAO_0000115: The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field.
has exact synonym: cardiac crescent morphogenesis

embryonic heart tube morphogenesis
type: Class
subclass of: GO_0048598
subclass of: GO_0060562
subclass of: part-of-parent-3007
subclass of: part-of-parent-35050
subclass of: part-of-parent-48562
IAO_0000115: The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.

embryonic heart tube formation
type: Class
subclass of: embryonic epithelial tube formation
subclass of: part-of-parent-3143
IAO_0000115: The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.

embryonic heart tube formation via epithelial folding
type: Class
subclass of: embryonic heart tube formation
IAO_0000115: The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis.

heart jogging
type: Class
subclass of: embryonic heart tube morphogenesis
subclass of: part-of-parent-61371
IAO_0000115: The morphogenetic process in which the heart cone is displaced to the left with respect to the vector of the anterior-posterior axis.
has exact synonym: cardiac jogging

neural crest cell migration involved in heart formation
type: Class
subclass of: neural crest cell migration
subclass of: GO_0060974
subclass of: part-of-parent-60914
subclass of: part-of-parent-61308
IAO_0000115: The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation.

outflow tract septum morphogenesis
type: Class
subclass of: GO_0060411
subclass of: part-of-parent-3151
IAO_0000115: The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract.

membranous septum morphogenesis
type: Class
subclass of: GO_0009653
subclass of: part-of-parent-60412
IAO_0000115: The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum.

muscular septum morphogenesis
type: Class
subclass of: GO_0060415
subclass of: part-of-parent-60412
IAO_0000115: The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum.

outflow tract morphogenesis
type: Class
subclass of: GO_0009653
subclass of: part-of-parent-3007
IAO_0000115: The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.

morphogenesis of an epithelial fold involved in embryonic heart tube formation
type: Class
subclass of: GO_0048598
subclass of: GO_0060571
subclass of: part-of-parent-3144
subclass of: part-of-parent-3145
IAO_0000115: The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation.

closure of embryonic heart tube
type: Class
subclass of: GO_0060606
subclass of: part-of-parent-3145
IAO_0000115: Creation of the central hole of the embryonic heart tube by sealing the edges of an epithelial fold.

BMP signaling pathway involved in determination of left/right symmetry
type: Class
subclass of: GO_0030509
subclass of: part-of-parent-7368
IAO_0000115: The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the determination of left/right symmetry.
has exact synonym: BMP signaling pathway involved in determination of left/right asymmetry
has exact synonym: BMP signalling pathway involved in determination of left/right symmetry

BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry
type: Class
subclass of: BMP signaling pathway involved in determination of left/right symmetry
subclass of: part-of-parent-3140
IAO_0000115: The series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the determination of lateral mesoderm left/right asymmetry.
has exact synonym: BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination
has exact synonym: BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry

regulation of animal organ formation
type: Class
subclass of: GO_2000027
IAO_0000115: Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment.

endocardium development
type: Class
subclass of: GO_0048856
subclass of: part-of-parent-7507
IAO_0000115: The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.

endothelium development
type: Class
subclass of: GO_0060429
IAO_0000115: The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.

morphogenesis of an endothelium
type: Class
subclass of: morphogenesis of an epithelium
subclass of: part-of-parent-3158
IAO_0000115: The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.

endocardium morphogenesis
type: Class
subclass of: GO_0009653
subclass of: part-of-parent-3157
IAO_0000115: The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.

cardiac conduction system development
type: Class
subclass of: GO_0048738
IAO_0000115: The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat.
has exact synonym: cardiac impulse conducting system development
has exact synonym: heart conduction system development

atrioventricular node development
type: Class
subclass of: GO_0048738
subclass of: part-of-parent-3161
IAO_0000115: The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system.
has exact synonym: AV node development

sinoatrial node development
type: Class
subclass of: atrial cardiac muscle tissue development
subclass of: part-of-parent-3161
IAO_0000115: The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node.
has exact synonym: SAN development
has exact synonym: SA node development
has related synonym: sinus node development

His-Purkinje system development
type: Class
subclass of: ventricular cardiac muscle tissue development
subclass of: part-of-parent-3161
IAO_0000115: The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles.

Purkinje myocyte development
type: Class
subclass of: ventricular cardiac muscle tissue development
subclass of: part-of-parent-3164
IAO_0000115: The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle.
has exact synonym: cardiac Purkinje fiber development

bundle of His development
type: Class
subclass of: ventricular cardiac muscle tissue development
subclass of: part-of-parent-3164
IAO_0000115: The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers.
has exact synonym: atrioventricular bundle development

atrioventricular bundle cell differentiation
type: Class
subclass of: GO_0060932
subclass of: part-of-parent-3166
IAO_0000115: The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the atrioventricular bundle. These cells are specialized cardiomyocytes that transmit signals from the AV node to the cardiac Purkinje fibers.
has exact synonym: AV bundle cell differentiation

Purkinje myocyte differentiation
type: Class
subclass of: GO_0060932
subclass of: part-of-parent-3165
IAO_0000115: The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle.
has exact synonym: cardiac Purkinje fiber cell differentiation

coronary vein morphogenesis
type: Class
subclass of: GO_0048845
subclass of: GO_0060977
IAO_0000115: The process in which the anatomical structures of veins of the heart are generated and organized.

heart valve development
type: Class
subclass of: GO_0048856
subclass of: part-of-parent-7507
IAO_0000115: The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion.
has exact synonym: cardiac valve development

atrioventricular valve development
type: Class
subclass of: heart valve development
IAO_0000115: The progression of the atrioventricular valve over time, from its formation to the mature structure.
has exact synonym: AV valve development

sinoatrial valve development
type: Class
subclass of: heart valve development
IAO_0000115: The progression of the sinoatrial valve over time, from its formation to the mature structure.
has exact synonym: SA valve development

ventriculo bulbo valve development
type: Class
subclass of: heart valve development
IAO_0000115: The progression of the ventriculo bulbo valve over time, from its formation to the mature structure.

mitral valve development
type: Class
subclass of: atrioventricular valve development
IAO_0000115: The progression of the mitral valve over time, from its formation to the mature structure.

tricuspid valve development
type: Class
subclass of: atrioventricular valve development
IAO_0000115: The progression of the tricuspid valve over time, from its formation to the mature structure.

aortic valve development
type: Class
subclass of: GO_1905314
IAO_0000115: The progression of the aortic valve over time, from its formation to the mature structure.

pulmonary valve development
type: Class
subclass of: GO_1905314
IAO_0000115: The progression of the pulmonary valve over time, from its formation to the mature structure.

coronary sinus valve development
type: Class
subclass of: heart valve development
IAO_0000115: The progression of the valve of the coronary sinus over time, from its formation to the mature structure.

heart valve morphogenesis
type: Class
subclass of: GO_0009653
subclass of: part-of-parent-3170
IAO_0000115: The process in which the structure of a heart valve is generated and organized.
has related synonym: heart valve remodeling
has related synonym: heart valve remodelling

aortic valve morphogenesis
type: Class
subclass of: heart valve morphogenesis
subclass of: part-of-parent-3176
IAO_0000115: The process in which the structure of the aortic valve is generated and organized.

atrioventricular valve morphogenesis
type: Class
subclass of: heart valve morphogenesis
subclass of: part-of-parent-3171
IAO_0000115: The process in which the structure of the atrioventricular valve is generated and organized.
has exact synonym: AV valve morphogenesis

coronary sinus valve morphogenesis
type: Class
subclass of: heart valve morphogenesis
subclass of: part-of-parent-3178
IAO_0000115: The process in which the structure of the coronary sinus valve is generated and organized.

mitral valve morphogenesis
type: Class
subclass of: atrioventricular valve morphogenesis
subclass of: part-of-parent-3174
IAO_0000115: The process in which the structure of the mitral valve is generated and organized.

pulmonary valve morphogenesis
type: Class
subclass of: heart valve morphogenesis
subclass of: part-of-parent-3177
IAO_0000115: The process in which the structure of the pulmonary valve is generated and organized.

sinoatrial valve morphogenesis
type: Class
subclass of: heart valve morphogenesis
subclass of: part-of-parent-3172
IAO_0000115: The process in which the structure of the sinoatrial valve is generated and organized.
has exact synonym: SA valve morphogenesis

tricuspid valve morphogenesis
type: Class
subclass of: atrioventricular valve morphogenesis
subclass of: part-of-parent-3175
IAO_0000115: The process in which the structure of the tricuspid valve is generated and organized.

ventriculo bulbo valve morphogenesis
type: Class
subclass of: heart valve morphogenesis
subclass of: part-of-parent-3173
IAO_0000115: The process in which the structure of the ventriculo bulbo valve is generated and organized.

heart valve formation
type: Class
subclass of: GO_0048646
subclass of: part-of-parent-3179
IAO_0000115: The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.

aortic valve formation
type: Class
subclass of: heart valve formation
subclass of: part-of-parent-3180
IAO_0000115: The developmental process pertaining to the initial formation of the aortic valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.

atrioventricular valve formation
type: Class
subclass of: heart valve formation
subclass of: part-of-parent-3181
IAO_0000115: The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
has exact synonym: AV valve formation

coronary sinus valve formation
type: Class
subclass of: heart valve formation
subclass of: part-of-parent-3182
IAO_0000115: The developmental process pertaining to the initial formation of the coronary sinus valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.

mitral valve formation
type: Class
subclass of: atrioventricular valve formation
subclass of: part-of-parent-3183
IAO_0000115: The developmental process pertaining to the initial formation of the mitral valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.

pulmonary valve formation
type: Class
subclass of: heart valve formation
subclass of: part-of-parent-3184
IAO_0000115: The developmental process pertaining to the initial formation of the pulmonary valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.

sinoatrial valve formation
type: Class
subclass of: heart valve formation
subclass of: part-of-parent-3185
IAO_0000115: The developmental process pertaining to the initial formation of the sinoatrial valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
has exact synonym: SA valve formation

tricuspid valve formation
type: Class
subclass of: atrioventricular valve formation
subclass of: part-of-parent-3186
IAO_0000115: The developmental process pertaining to the initial formation of the tricuspid valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.

ventriculo bulbo valve formation
type: Class
subclass of: heart valve formation
subclass of: part-of-parent-3187
IAO_0000115: The developmental process pertaining to the initial formation of the ventriculo bulbo valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.

endocardial cushion development
type: Class
subclass of: GO_0060485
subclass of: part-of-parent-7507
IAO_0000115: The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.

epithelial to mesenchymal transition involved in endocardial cushion formation
type: Class
subclass of: GO_0060317
subclass of: part-of-parent-3272
IAO_0000115: A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion.

endocardial cushion to mesenchymal transition involved in heart valve formation
type: Class
subclass of: GO_0090500
subclass of: part-of-parent-3188
IAO_0000115: A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve.
has exact synonym: endocardial cushion to mesenchymal transition involved in valve formation

endocardial cushion to mesenchymal transition involved in heart chamber septation
type: Class
subclass of: GO_0090500
subclass of: part-of-parent-60411
IAO_0000115: A transition where an endocardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the heart septum.

epithelial to mesenchymal transition involved in coronary vasculature morphogenesis
type: Class
subclass of: GO_0060317
subclass of: part-of-parent-60977
IAO_0000115: A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the shaping of the coronary vasculature.

endocardial cushion to mesenchymal transition involved in cardiac skeleton development
type: Class
subclass of: GO_0090500
subclass of: part-of-parent-3204
IAO_0000115: A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will give rise to the cardiac skeleton.

endocardial cushion morphogenesis
type: Class
subclass of: GO_0072132
subclass of: part-of-parent-3007
subclass of: part-of-parent-3197
IAO_0000115: The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.

cardiac skeleton development
type: Class
subclass of: GO_0061448
subclass of: part-of-parent-7507
IAO_0000115: The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart.
has exact synonym: heart fibrous skeleton development

cardiac chamber development
type: Class
subclass of: GO_0048856
subclass of: part-of-parent-7507
IAO_0000115: The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart.

cardiac chamber morphogenesis
type: Class
subclass of: GO_0009653
subclass of: part-of-parent-3007
subclass of: part-of-parent-3205
IAO_0000115: The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.
has exact synonym: heart chamber morphogenesis

cardiac chamber formation
type: Class
subclass of: GO_0048646
subclass of: part-of-parent-3206
IAO_0000115: The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart.
has exact synonym: heart chamber formation

cardiac ventricle morphogenesis
type: Class
subclass of: cardiac chamber morphogenesis
subclass of: part-of-parent-3231
IAO_0000115: The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.

cardiac atrium morphogenesis
type: Class
subclass of: cardiac chamber morphogenesis
subclass of: part-of-parent-3230
IAO_0000115: The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.

cardiac atrium formation
type: Class
subclass of: cardiac chamber formation
subclass of: part-of-parent-3209
IAO_0000115: The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.

cardiac ventricle formation
type: Class
subclass of: cardiac chamber formation
subclass of: part-of-parent-3208
IAO_0000115: The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.

cardiac left atrium morphogenesis
type: Class
subclass of: cardiac atrium morphogenesis
IAO_0000115: The process in which the left cardiac atrium is generated and organized.

cardiac right atrium morphogenesis
type: Class
subclass of: cardiac atrium morphogenesis
IAO_0000115: The process in which the right cardiac atrium is generated and organized.

cardiac left ventricle morphogenesis
type: Class
subclass of: cardiac ventricle morphogenesis
IAO_0000115: The process in which the left cardiac ventricle is generated and organized.

cardiac right ventricle morphogenesis
type: Class
subclass of: cardiac ventricle morphogenesis
IAO_0000115: The process in which the right cardiac ventricle is generated and organized.

cardiac left atrium formation
type: Class
subclass of: cardiac atrium formation
subclass of: part-of-parent-3212
IAO_0000115: The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts.

cardiac right atrium formation
type: Class
subclass of: cardiac atrium formation
subclass of: part-of-parent-3213
IAO_0000115: The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts.

cardiac left ventricle formation
type: Class
subclass of: cardiac ventricle formation
subclass of: part-of-parent-3214
IAO_0000115: The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts.

cardiac right ventricle formation
type: Class
subclass of: cardiac ventricle formation
subclass of: part-of-parent-3215
IAO_0000115: The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts.

left ventricular cardiac muscle tissue morphogenesis
type: Class
subclass of: GO_0055010
subclass of: part-of-parent-3214
IAO_0000115: The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized.
has exact synonym: left ventricular myocardium morphogenesis

right ventricular cardiac muscle tissue morphogenesis
type: Class
subclass of: GO_0055010
subclass of: part-of-parent-3215
IAO_0000115: The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized.
has exact synonym: right ventricle myocardium morphogenesis

ventricular trabecula myocardium morphogenesis
type: Class
subclass of: GO_0055010
subclass of: GO_0061384
IAO_0000115: The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized.
has related synonym: trabecula carnea morphogenesis

ventricular compact myocardium morphogenesis
type: Class
subclass of: GO_0055010
IAO_0000115: The process in which the anatomical structures of the compact cardiac ventricle muscle are generated and organized.

left ventricular compact myocardium morphogenesis
type: Class
subclass of: left ventricular cardiac muscle tissue morphogenesis
subclass of: ventricular compact myocardium morphogenesis
IAO_0000115: The process in which the anatomical structures of cardiac left ventricular compact myocardium are generated and organized.

left ventricular trabecular myocardium morphogenesis
type: Class
subclass of: left ventricular cardiac muscle tissue morphogenesis
subclass of: ventricular trabecula myocardium morphogenesis
IAO_0000115: The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized.

right ventricular compact myocardium morphogenesis
type: Class
subclass of: right ventricular cardiac muscle tissue morphogenesis
subclass of: ventricular compact myocardium morphogenesis
IAO_0000115: The process in which the anatomical structures of the right ventricular compact myocardium are generated and organized.

right ventricular trabecular myocardium morphogenesis
type: Class
subclass of: right ventricular cardiac muscle tissue morphogenesis
subclass of: ventricular trabecula myocardium morphogenesis
IAO_0000115: The process in which the anatomical structures of the right ventricular myocardium are generated and organized.

atrial cardiac muscle tissue development
type: Class
subclass of: GO_0048738
IAO_0000115: The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure.
has exact synonym: atrial myocardium development

ventricular cardiac muscle tissue development
type: Class
subclass of: GO_0048738
IAO_0000115: The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure.
has exact synonym: ventricular myocardium development

cardiac atrium development
type: Class
subclass of: cardiac chamber development
IAO_0000115: The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.

cardiac ventricle development
type: Class
subclass of: cardiac chamber development
IAO_0000115: The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.

bulbus arteriosus development
type: Class
subclass of: cardiac chamber development
IAO_0000115: The process whose specific outcome is the progression of the bulbus arteriosus over time, from its formation to the mature structure. The bulbus arteriosus is an elastic heart chamber.

bulbus arteriosus morphogenesis
type: Class
subclass of: cardiac chamber morphogenesis
subclass of: part-of-parent-3232
IAO_0000115: The process in which the bulbus arteriosus is generated and organized. The bulbus arteriosus is an elastic cardiac chamber.

bulbus arteriosus formation
type: Class
subclass of: cardiac chamber formation
subclass of: part-of-parent-3233
IAO_0000115: The developmental process pertaining to the initial formation of the bulbus arteriosus from unspecified parts. The bulbus arteriosus is an elastic chamber of the heart.

sinus venosus development
type: Class
subclass of: cardiac chamber development
IAO_0000115: The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart.

sinus venosus morphogenesis
type: Class
subclass of: cardiac chamber morphogenesis
subclass of: part-of-parent-3235
IAO_0000115: The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart.

sinus venosus formation
type: Class
subclass of: cardiac chamber formation
subclass of: part-of-parent-3236
IAO_0000115: The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart.

conus arteriosus development
type: Class
subclass of: cardiac chamber development
IAO_0000115: The progression of the conus arteriosus over time, from its formation to the mature structure. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk.

conus arteriosus morphogenesis
type: Class
subclass of: cardiac chamber morphogenesis
subclass of: part-of-parent-3238
IAO_0000115: The process in which the conus arteriosus is generated and organized. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk.

conus arteriosus formation
type: Class
subclass of: cardiac chamber formation
subclass of: part-of-parent-3239
IAO_0000115: The developmental process pertaining to the initial formation of the conus arteriosus from unspecified parts. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk.

growth involved in heart morphogenesis
type: Class
subclass of: GO_0060560
subclass of: part-of-parent-3007
subclass of: part-of-parent-60419
IAO_0000115: Developmental growth that contributes to the shaping of the heart.

cardiac chamber ballooning
type: Class
subclass of: growth involved in heart morphogenesis
subclass of: part-of-parent-3206
IAO_0000115: The morphogenic growth in which the chambers of the heart expand in size, contributing to their shaping.

circumferential growth involved in left ventricle morphogenesis
type: Class
subclass of: growth involved in heart morphogenesis
subclass of: part-of-parent-3214
IAO_0000115: The morphogenetic growth in which the left ventricle grows expanding its external boundary.

radial growth involved in right ventricle morphogenesis
type: Class
subclass of: growth involved in heart morphogenesis
subclass of: part-of-parent-3215
IAO_0000115: The morphogenic growth in which the right ventricle grows along a radial axis.

cardiac muscle tissue growth involved in heart morphogenesis
type: Class
subclass of: growth involved in heart morphogenesis
subclass of: GO_0055017
subclass of: part-of-parent-3007
subclass of: part-of-parent-55008
IAO_0000115: The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart.

embryonic cardiac muscle cell growth involved in heart morphogenesis
type: Class
subclass of: growth involved in heart morphogenesis
subclass of: GO_0061049
subclass of: part-of-parent-3245
IAO_0000115: The growth of a cardiac muscle cell during the embryonic period, that contributes to the shaping of the heart.
has exact synonym: embryonic cardiac muscle physiological hypertrophy

post-embryonic cardiac muscle cell growth involved in heart morphogenesis
type: Class
subclass of: growth involved in heart morphogenesis
subclass of: GO_0048588
subclass of: part-of-parent-3245
IAO_0000115: The growth of a cardiac muscle cell during the postembryonic period that contributes to the shaping of the heart.

heart capillary growth
type: Class
subclass of: GO_0048589
subclass of: part-of-parent-60419
subclass of: part-of-parent-60976
IAO_0000115: The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle.

cell proliferation involved in heart valve morphogenesis
type: Class
subclass of: GO_0061323
subclass of: GO_2000793
subclass of: part-of-parent-3179
IAO_0000115: The multiplication or reproduction of cells that contributes to the shaping of a heart valve.

regulation of cell proliferation involved in heart valve morphogenesis
type: Class
subclass of: GO_2000136
IAO_0000115: Any process that modulates the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve.

positive regulation of cell proliferation involved in heart valve morphogenesis
type: Class
subclass of: regulation of cell proliferation involved in heart valve morphogenesis
subclass of: GO_2000138
IAO_0000115: Any process that increases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve.

negative regulation of cell proliferation involved in heart valve morphogenesis
type: Class
subclass of: regulation of cell proliferation involved in heart valve morphogenesis
subclass of: GO_2000137
IAO_0000115: Any process that decreases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve.

cardiac neural crest cell migration involved in outflow tract morphogenesis
type: Class
subclass of: neural crest cell migration
subclass of: GO_0060973
subclass of: part-of-parent-3151
subclass of: part-of-parent-61309
IAO_0000115: The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract.

regulation of membrane depolarization
type: Class
subclass of: GO_0042391
subclass of: GO_0050794
IAO_0000115: Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive.

endocardial precursor cell differentiation
type: Class
subclass of: GO_0010002
IAO_0000115: The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of an endocardial precursor cell. A endocardial precursor cell is a cell that has been committed to a endocardial cell fate, but will undergo further cell divisions rather than terminally differentiate.

obsolete regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell.

obsolete positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell.

obsolete regulation of transcription from RNA polymerase II promoter involved in endocardial precursor cell differentiation
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of an endocardial precursor cell.

cardioblast anterior-lateral migration
type: Class
subclass of: cardioblast migration
IAO_0000115: The orderly movement of a cardioblast toward the head and laterally to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.

cardioblast migration
type: Class
subclass of: GO_0060974
IAO_0000115: The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.

cardiac muscle progenitor cell migration to the midline involved in heart field formation
type: Class
subclass of: GO_0060975
IAO_0000115: The orderly movement of a myocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into myocardial cells of the heart.
has exact synonym: myocardial progenitor cell midline convergence

endocardial progenitor cell migration to the midline involved in heart field formation
type: Class
subclass of: GO_0060975
IAO_0000115: The orderly movement of an endocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into endocardial cells of the heart.

cardioblast proliferation
type: Class
subclass of: GO_0061323
subclass of: part-of-parent-60914
IAO_0000115: The multiplication or reproduction of cardioblasts, resulting in the expansion of the population in the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.

regulation of cardioblast proliferation
type: Class
subclass of: GO_2000136
IAO_0000115: Any process that modulates the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.

regulation of primary heart field cardioblast proliferation
type: Class
subclass of: regulation of cardioblast proliferation
IAO_0000115: Any process that modulates the frequency, rate or extent of cardioblast proliferation in the primary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. In mammals the primary heart field gives rise to the left ventricle.
has exact synonym: regulation of FHF cardioblast proliferation
has related synonym: regulation of first heart field cardiac proliferation
has exact synonym: regulation of first heart field cardioblast proliferation

regulation of secondary heart field cardioblast proliferation
type: Class
subclass of: regulation of cardioblast proliferation
IAO_0000115: Any process that modulates the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract).
has exact synonym: regulation of second heart field cardioblast proliferation
has exact synonym: regulation of SHF cardioblast proliferation

canonical Wnt signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation
type: Class
subclass of: GO_0044340
subclass of: GO_0061316
subclass of: part-of-parent-72513
IAO_0000115: A canonical Wnt signaling pathway that contributes to an increase in the frequency, or rate of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
has related synonym: canonical Wnt-activated signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation
has exact synonym: canonical Wnt receptor signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation
has exact synonym: canonical Wnt receptor signaling pathway involved in positive regulation of second heart field cardioblast proliferation
has exact synonym: canonical Wnt receptor signalling pathway involved in positive regulation of secondary heart field cardioblast proliferation

fibroblast growth factor receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation
type: Class
subclass of: GO_0061313
subclass of: part-of-parent-3266
IAO_0000115: The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
has exact synonym: fibroblast growth factor receptor signaling pathway involved in regulation of secondary heart field cardioblast cell proliferation
has exact synonym: fibroblast growth factor receptor signaling pathway involved in regulation of second heart field cardioblast cell proliferation
has exact synonym: fibroblast growth factor receptor signalling pathway involved in regulation of secondary heart field cardioblast cell proliferation

BMP signaling pathway involved in regulation of secondary heart field cardioblast proliferation
type: Class
subclass of: GO_0061312
subclass of: part-of-parent-3266
IAO_0000115: The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
has exact synonym: BMP signaling pathway involved in regulation of second heart field cardioblast proliferation
has exact synonym: BMP signalling pathway involved in regulation of secondary heart field cardioblast proliferation

Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
type: Class
subclass of: GO_0061314
subclass of: part-of-parent-3266
IAO_0000115: The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
has related synonym: Notch signaling pathway involved in regulation of second heart field cardioblast proliferation
has exact synonym: Notch signalling pathway involved in regulation of secondary heart field cardioblast proliferation

smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation
type: Class
subclass of: GO_0007224
subclass of: GO_0061311
subclass of: part-of-parent-3266
IAO_0000115: The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
has exact synonym: hedgehog signaling pathway involved in regulation of second heart field cardioblast proliferation
has exact synonym: hh signaling pathway involved in regulation of second heart field cardioblast proliferation
has exact synonym: smoothened receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation
has exact synonym: smoothened receptor signaling pathway involved in regulation of second heart field cardioblast proliferation
has exact synonym: smoothened receptor signalling pathway involved in regulation of secondary heart field cardioblast proliferation

endocardial cushion formation
type: Class
subclass of: GO_0048646
subclass of: part-of-parent-3203
IAO_0000115: The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.

cell migration involved in endocardial cushion formation
type: Class
subclass of: GO_0060973
subclass of: part-of-parent-3272
IAO_0000115: The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.

endocardial cushion fusion
type: Class
subclass of: GO_0061343
subclass of: GO_0098742
subclass of: part-of-parent-3203
IAO_0000115: The cell-cell adhesion process of mesenchymal cardiac cushion cells that contributes to the process of cushion shaping.

apoptotic process involved in outflow tract morphogenesis
type: Class
subclass of: apoptotic process involved in heart morphogenesis
subclass of: part-of-parent-3151
IAO_0000115: Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries.
has related synonym: apoptosis involved in outflow tract morphogenesis

apoptotic process involved in heart valve morphogenesis
type: Class
subclass of: apoptotic process involved in heart morphogenesis
subclass of: part-of-parent-3179
IAO_0000115: Any apoptotic process that contributes to the shaping of a heart valve.
has related synonym: apoptosis involved in heart valve morphogenesis

apoptotic process involved in endocardial cushion morphogenesis
type: Class
subclass of: apoptotic process involved in heart morphogenesis
subclass of: part-of-parent-3203
IAO_0000115: Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.
has related synonym: apoptosis involved in endocardial cushion morphogenesis

apoptotic process involved in heart morphogenesis
type: Class
subclass of: GO_0060561
subclass of: part-of-parent-3007
IAO_0000115: Any apoptotic process that contributes to the shaping of the heart.
has related synonym: apoptosis involved in heart morphogenesis

cardiac septum development
type: Class
subclass of: GO_0048856
subclass of: part-of-parent-3205
IAO_0000115: The progression of a cardiac septum over time, from its initial formation to the mature structure.
has exact synonym: heart septum development

ventricular septum development
type: Class
subclass of: cardiac septum development
subclass of: part-of-parent-3231
IAO_0000115: The progression of the ventricular septum over time from its formation to the mature structure.
has exact synonym: interventricular septum development
has related synonym: septum inferius development

ventricular septum intermedium development
type: Class
subclass of: ventricular septum development
IAO_0000115: The progression of the ventricular septum intermedium over time, from its formation to the mature structure.

atrial septum development
type: Class
subclass of: cardiac septum development
subclass of: part-of-parent-3230
IAO_0000115: The progression of the atrial septum over time, from its initial formation to the mature structure.

septum primum development
type: Class
subclass of: atrial septum development
IAO_0000115: The progression of the septum primum over time, from its formation to the mature structure.

septum secundum development
type: Class
subclass of: atrial septum development
IAO_0000115: The progression of the septum secundum over time, from its initial formation to the mature structure.

atrial septum intermedium development
type: Class
subclass of: atrial septum development
IAO_0000115: The progression of the atrial septum intermedium over time, from its formation to the mature structure.

ventricular septum intermedium morphogenesis
type: Class
subclass of: GO_0060412
IAO_0000115: The developmental process in which a ventricular septum intermedium is generated and organized.

atrial septum primum morphogenesis
type: Class
subclass of: GO_0060413
subclass of: part-of-parent-3284
IAO_0000115: The process in which anatomical structure of an atrial septum primum is generated and organized.

atrial septum secundum morphogenesis
type: Class
subclass of: GO_0060413
subclass of: part-of-parent-3285
IAO_0000115: The process in which anatomical structure of an atrial septum secundum is generated and organized.

atrial septum intermedium morphogenesis
type: Class
subclass of: GO_0060413
subclass of: part-of-parent-3286
IAO_0000115: The process in which anatomical structure of an atrial septum intermedium is generated and organized.

cardiac septum cell differentiation
type: Class
subclass of: GO_0035051
subclass of: part-of-parent-3279
IAO_0000115: The process in which an endocardial cushion cell becomes a cell of a cardiac septum.

heart valve cell differentiation
type: Class
subclass of: GO_0035051
subclass of: part-of-parent-3170
IAO_0000115: The process in which an endocardial cushion cell give rise to a cell that is part of a heart valve.

atrial ventricular junction remodeling
type: Class
subclass of: GO_0048771
subclass of: part-of-parent-3007
IAO_0000115: The reorganization or renovation of heart tissue that contributes to the maturation of the connection between an atrium and a ventricle.
has exact synonym: atrioventricular junction remodeling
has related synonym: atrio-ventricular junction remodeling

cell proliferation involved in atrial ventricular junction remodeling
type: Class
subclass of: GO_0061323
subclass of: part-of-parent-3294
IAO_0000115: The multiplication or reproduction of cells that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction.
has exact synonym: cell proliferation involved in atrioventricular junction remodeling
has exact synonym: cell proliferation involved in atrio-ventricular junction remodeling

apoptotic process involved in atrial ventricular junction remodeling
type: Class
subclass of: apoptotic process involved in heart morphogenesis
subclass of: part-of-parent-3294
IAO_0000115: Any apoptotic process that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction.
has related synonym: apoptosis involved in atrial ventricular junction remodeling
has exact synonym: apoptosis involved in atrioventricular junction remodeling
has exact synonym: apoptosis involved in atrio-ventricular junction remodeling

heart wedging
type: Class
subclass of: GO_0009653
subclass of: part-of-parent-3007
IAO_0000115: The morphogenetic process in which the aorta inserts between the atrioventricular valves, contributing to the shaping of the heart.

physiological muscle hypertrophy
type: Class
subclass of: GO_0014896
IAO_0000115: The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development.

muscle hypertrophy in response to stress
type: Class
subclass of: GO_0006950
subclass of: GO_0014896
subclass of: GO_0043500
IAO_0000115: The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis.

cardiac muscle hypertrophy
type: Class
subclass of: GO_0014897
IAO_0000115: The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division.

physiological cardiac muscle hypertrophy
type: Class
subclass of: physiological muscle hypertrophy
subclass of: cardiac muscle hypertrophy
subclass of: part-of-parent-55017
IAO_0000115: The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart.

transforming growth factor beta receptor signaling pathway involved in heart jogging
type: Class
subclass of: GO_0035463
subclass of: GO_1905313
subclass of: part-of-parent-3146
IAO_0000115: The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the process of heart jogging.
has exact synonym: transforming growth factor beta receptor signalling pathway involved in heart jogging

BMP signaling pathway involved in heart jogging
type: Class
subclass of: BMP signaling pathway involved in determination of left/right symmetry
subclass of: GO_0061312
subclass of: part-of-parent-3146
IAO_0000115: The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the process of heart jogging.
has exact synonym: BMP signalling pathway involved in heart jogging

myocardial epithelial involution involved in heart jogging
type: Class
subclass of: GO_0060571
subclass of: part-of-parent-3146
IAO_0000115: The morphogenetic process in which the myocardium bends along a linear axis and contributes to the process of heart jogging.

cell migration involved in heart jogging
type: Class
subclass of: GO_0060973
subclass of: part-of-parent-3146
IAO_0000115: The orderly movement of a cell of the myocardium from one site to another that will contribute to heart jogging.

Wnt signaling pathway involved in heart development
type: Class
subclass of: GO_0016055
subclass of: GO_0061311
subclass of: part-of-parent-7507
IAO_0000115: The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time.
has exact synonym: Wnt-activated signaling pathway involved in heart development
has exact synonym: Wnt receptor signaling pathway involved in heart development
has exact synonym: Wnt receptor signalling pathway involved in heart development

regulation of Wnt signaling pathway involved in heart development
type: Class
subclass of: GO_0030111
IAO_0000115: Any process that modulates the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time.
has exact synonym: regulation of Wnt-activated signaling pathway involved in heart development
has exact synonym: regulation of Wnt receptor signaling pathway involved in heart development
has exact synonym: regulation of Wnt receptor signalling pathway involved in heart development

negative regulation of Wnt signaling pathway involved in heart development
type: Class
subclass of: regulation of Wnt signaling pathway involved in heart development
subclass of: GO_0030178
subclass of: GO_0051093
subclass of: GO_0051241
IAO_0000115: Any process that decreases the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time.
has exact synonym: negative regulation of Wnt-activated signaling pathway involved in heart development
has exact synonym: negative regulation of Wnt receptor signaling pathway involved in heart development
has exact synonym: negative regulation of Wnt receptor signalling pathway involved in heart development

type B pancreatic cell differentiation
type: Class
subclass of: GO_0035883
subclass of: part-of-parent-31018
IAO_0000115: The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
has exact synonym: pancreatic B cell differentiation
has exact synonym: pancreatic beta cell differentiation

pancreatic A cell differentiation
type: Class
subclass of: GO_0035883
subclass of: part-of-parent-31018
IAO_0000115: The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.
has exact synonym: pancreatic alpha cell differentiation

pancreatic D cell differentiation
type: Class
subclass of: GO_0035883
subclass of: part-of-parent-31018
IAO_0000115: The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin.
has exact synonym: pancreatic delta cell differentiation

pancreatic PP cell differentiation
type: Class
subclass of: GO_0035883
subclass of: part-of-parent-31018
IAO_0000115: The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide.
has exact synonym: pancreatic polypeptide-producing cell differentiation

heart rudiment development
type: Class
subclass of: GO_0060429
subclass of: part-of-parent-35050
IAO_0000115: The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube.
has exact synonym: heart cone development

heart rudiment morphogenesis
type: Class
subclass of: morphogenesis of an epithelium
subclass of: GO_0048598
subclass of: part-of-parent-3313
IAO_0000115: The process in which the anatomical structures of the heart rudiment are generated and organized.
has exact synonym: heart cone morphogenesis

heart rudiment formation
type: Class
subclass of: GO_0048646
subclass of: part-of-parent-3314
IAO_0000115: The developmental process pertaining to the initial formation of the heart rudiment.
has exact synonym: heart cone formation

establishment of myocardial progenitor cell apical/basal polarity
type: Class
subclass of: GO_0045198
subclass of: part-of-parent-3315
IAO_0000115: The specification and formation of the apicobasal polarity of an myocardial progenitor cell that contributes to the formation of the heart rudiment.
has exact synonym: myocardial progenitor epithelial polarization

cardioblast cell midline fusion
type: Class
subclass of: GO_0034109
subclass of: part-of-parent-3315
IAO_0000115: The attachment of cardiac progenitor cells to one another that contributes to the formation of the heart rudiment.
has exact synonym: cardiac progenitor cell midline fusion

cell migration to the midline involved in heart development
type: Class
subclass of: GO_0060973
IAO_0000115: The orderly movement of a cell toward the midline that contributes to the progression of the heart over time.

cardioblast migration to the midline involved in heart rudiment formation
type: Class
subclass of: cell migration to the midline involved in heart development
subclass of: part-of-parent-3315
IAO_0000115: The orderly movement of a cardioblast toward the midline that contributes to the initial appearance of the heart rudiment.

heart rudiment involution
type: Class
subclass of: morphogenesis of an epithelial fold involved in embryonic heart tube formation
IAO_0000115: The inward folding of myocardial tissue derived from the right half of the heart rudiment that will form the future ventral part of the heart tube.

positive regulation of blood pressure by epinephrine-norepinephrine
type: Class
subclass of: regulation of systemic arterial blood pressure by norepinephrine-epinephrine
subclass of: GO_0045777
IAO_0000115: Any process in which the force of blood traveling through the circulatory system is increased by the chemicals epinephrine and norepinephrine.

pancreatic A cell development
type: Class
subclass of: glandular epithelial cell development
subclass of: part-of-parent-3310
IAO_0000115: The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon.
has exact synonym: pancreatic alpha cell development

type B pancreatic cell development
type: Class
subclass of: glandular epithelial cell development
subclass of: part-of-parent-3309
IAO_0000115: The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
has exact synonym: pancreatic B cell development
has exact synonym: pancreatic beta cell development

pancreatic D cell development
type: Class
subclass of: glandular epithelial cell development
subclass of: part-of-parent-3311
IAO_0000115: The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin.
has exact synonym: pancreatic delta cell development

pancreatic PP cell development
type: Class
subclass of: glandular epithelial cell development
subclass of: part-of-parent-3312
IAO_0000115: The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide.

pancreatic A cell fate commitment
type: Class
subclass of: GO_0072148
subclass of: part-of-parent-3310
IAO_0000115: The commitment of a cell to a pancreatic A cell and its capacity to differentiate into a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.

type B pancreatic cell fate commitment
type: Class
subclass of: GO_0072148
subclass of: part-of-parent-3309
IAO_0000115: The commitment of a cell to a type B pancreatic cell fate and its capacity to differentiate into a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
has exact synonym: pancreatic B cell fate commitment

pancreatic D cell fate commitment
type: Class
subclass of: GO_0072148
subclass of: part-of-parent-3311
IAO_0000115: The commitment of a cell to a pancreatic D cell fate and its capacity to differentiate into a pancreatic D cell. A delta cell is a cell of the pancreas that produces somatostatin.

pancreatic PP cell fate commitment
type: Class
subclass of: GO_0072148
subclass of: part-of-parent-3312
IAO_0000115: The commitment of a cell to a pancreatic PP cell fate and its capacity to differentiate into a pancreatic PP cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide.

regulation of extracellular matrix constituent secretion
type: Class
subclass of: GO_1903053
subclass of: GO_1903530
IAO_0000115: Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.

positive regulation of extracellular matrix constituent secretion
type: Class
subclass of: regulation of extracellular matrix constituent secretion
subclass of: GO_1903055
subclass of: GO_1903532
IAO_0000115: Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.

negative regulation of extracellular matrix constituent secretion
type: Class
subclass of: regulation of extracellular matrix constituent secretion
subclass of: GO_1903054
subclass of: GO_1903531
IAO_0000115: Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.

amino acid transmembrane transport
type: Class
subclass of: GO_0006865
subclass of: GO_1905039
IAO_0000115: The process in which an amino acid is transported across a membrane.
has exact synonym: amino acid membrane transport

keratinocyte development
type: Class
subclass of: epithelial cell development
subclass of: part-of-parent-30216
IAO_0000115: The process whose specific outcome is the progression of a keratinocyte over time, from its formation to the mature structure.

corneocyte development
type: Class
subclass of: GO_0048468
subclass of: part-of-parent-3334
IAO_0000115: The process whose specific outcome is the progression of the corneocyte over time, from its formation to the mature structure. A corneocyte is the last stage of development of a keratinocyte where the keratinocyte flattens, loses its nucleus and eventually delaminates from the epidermis.

corneocyte desquamation
type: Class
subclass of: GO_0060232
subclass of: part-of-parent-3335
IAO_0000115: The delamination process that results in the shedding of a corneocyte from the surface of the epidermis.
has exact synonym: epidermal desquamation

mesenchymal to epithelial transition involved in metanephros morphogenesis
type: Class
subclass of: GO_0035850
subclass of: GO_0060231
subclass of: GO_0072202
subclass of: part-of-parent-3338
subclass of: part-of-parent-72283
IAO_0000115: A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.
has related synonym: metanephric mesenchyme to epithelial transition

metanephros morphogenesis
type: Class
subclass of: GO_0060993
subclass of: part-of-parent-1656
IAO_0000115: The process in which the anatomical structures of the metanephros are generated and organized.

regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
type: Class
subclass of: GO_2000696
IAO_0000115: Any process that modulates the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.

negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
type: Class
subclass of: regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
subclass of: GO_2000697
IAO_0000115: Any process that decreases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.

cilium movement
type: Class
subclass of: GO_0007018
IAO_0000115: The directed, self-propelled movement of a cilium.
has related synonym: ciliary motility
has related synonym: cilium beating
has related synonym: flagellar motility
has related synonym: flagellar movement
has related synonym: flagellum movement
has exact synonym: microtubule-based flagellum movement
replaces: GO_0036142

proepicardium development
type: Class
subclass of: GO_0060485
subclass of: part-of-parent-3343
IAO_0000115: The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum.

septum transversum development
type: Class
subclass of: GO_0060485
IAO_0000115: The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme.

pericardium morphogenesis
type: Class
subclass of: morphogenesis of an epithelial sheet
subclass of: GO_0048598
subclass of: part-of-parent-60039
IAO_0000115: The process in which the anatomical structure of the pericardium is generated and organized.

proepicardium cell migration involved in pericardium morphogenesis
type: Class
subclass of: GO_0060973
subclass of: part-of-parent-3344
IAO_0000115: The coordinated movement of a mesenchymal proepicardial cell to the surface of the developing heart.

epicardium-derived cell migration to the myocardium
type: Class
subclass of: GO_0060973
IAO_0000115: The orderly movement of a cell that have undergone an epithelial to mesenchymal transition from the epicardium into the myocardium.

epicardial cell to mesenchymal cell transition
type: Class
subclass of: epithelial to mesenchymal transition
IAO_0000115: A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. The epicardium is a part of the pericardium.

cardiac endothelial cell differentiation
type: Class
subclass of: GO_0035051
subclass of: GO_0045446
IAO_0000115: The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell.

epicardium-derived cardiac endothelial cell differentiation
type: Class
subclass of: cardiac endothelial cell differentiation
IAO_0000115: The process in which an epicardial cell acquires the specialized structural and/or functional features of a cardiac endothelial cell.

pulmonary myocardium development
type: Class
subclass of: GO_0014706
subclass of: part-of-parent-60841
IAO_0000115: The progression of the pulmonary myocardium over time, from its initial formation to the mature structure. The pulmonary myocardium is the myocardial tissue present in the pulmonary vein.

epithelial cilium movement involved in extracellular fluid movement
type: Class
subclass of: cilium movement
subclass of: GO_0006858
subclass of: GO_0099111
IAO_0000115: The directed, self-propelled movement of cilia of epithelial cells. Depending on the type of cell, there may be one or many cilia per cell. This movement is usually coordinated between many epithelial cells, and serves to move extracellular fluid.
has related synonym: cilium movement involved in fluid flow
has related synonym: epithelial cilium beating

regulation of cilium movement
type: Class
subclass of: GO_0060632
IAO_0000115: Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.
has related synonym: regulation of flagellar movement
has related synonym: regulation of flagellum movement
has exact synonym: regulation of microtubule-based flagellum movement
replaces: GO_1900172

positive regulation of cilium movement
type: Class
subclass of: regulation of cilium movement
subclass of: GO_0048522
IAO_0000115: Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.
has related synonym: positive regulation of flagellar movement
has related synonym: positive regulation of flagellum movement
has exact synonym: positive regulation of microtubule-based flagellum movement
replaces: GO_1900174

negative regulation of cilium movement
type: Class
subclass of: regulation of cilium movement
subclass of: GO_0048523
IAO_0000115: Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.
has related synonym: negative regulation of flagellum movement
has exact synonym: negative regulation of microtubule-based flagellum movement
replaces: GO_1900173

cilium movement involved in otolith formation
type: Class
subclass of: epithelial cilium movement involved in extracellular fluid movement
subclass of: part-of-parent-32475
IAO_0000115: The directed, self-propelled movement of cilia of inner ear epithelial cells, resulting the aggregation of otolith seed particles.

regulation of cilium beat frequency
type: Class
subclass of: regulation of cilium movement
IAO_0000115: Any process that modulates the frequency of cilium movement, the directed, self-propelled movement of a cilium.
has related synonym: regulation of flagellum beat frequency
has exact synonym: regulation of microtubule-based flagellum beat frequency
replaces: GO_0036144

noradrenergic neuron differentiation
type: Class
subclass of: GO_0030182
IAO_0000115: The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline.
has exact synonym: norepinephrine secreting neuron differentiation

noradrenergic neuron development
type: Class
subclass of: GO_0048666
subclass of: part-of-parent-3357
IAO_0000115: The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
has exact synonym: norepinephrine secreting neuron development

noradrenergic neuron fate commitment
type: Class
subclass of: GO_0048663
subclass of: part-of-parent-3357
IAO_0000115: The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron.
has exact synonym: norepinephrine secreting neuron fate commitment

brainstem development
type: Class
subclass of: GO_0048856
IAO_0000115: The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord.

noradrenergic neuron differentiation involved in brainstem development
type: Class
subclass of: noradrenergic neuron differentiation
subclass of: part-of-parent-3360
IAO_0000115: The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron that is part of the brainstem.

noradrenergic neuron fate commitment involved in brainstem development
type: Class
subclass of: noradrenergic neuron fate commitment
subclass of: part-of-parent-3360
subclass of: part-of-parent-3361
IAO_0000115: The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron that is part of the brainstem.

lamellipodium assembly involved in ameboidal cell migration
type: Class
subclass of: GO_0030032
subclass of: part-of-parent-1667
IAO_0000115: Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self propelled movement of a cell.

lamellipodium assembly involved in mesendodermal cell migration
type: Class
subclass of: lamellipodium assembly involved in ameboidal cell migration
subclass of: GO_0010927
subclass of: part-of-parent-90134
IAO_0000115: Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self-propelled movement of a mesendodermal cell.

establishment of cell polarity involved in ameboidal cell migration
type: Class
subclass of: GO_0030010
subclass of: part-of-parent-1667
IAO_0000115: The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell.

cell-matrix adhesion involved in ameboidal cell migration
type: Class
subclass of: GO_0007160
subclass of: part-of-parent-1667
IAO_0000115: The binding of a cell to the extracellular matrix that contributes to the directed movement of an ameboid cell.

cell-cell adhesion involved in ameboidal cell migration
type: Class
subclass of: GO_0098742
subclass of: part-of-parent-3365
IAO_0000115: The attachment of one ameboid cell to another that contributes to the establishment of cell polarity that is part of the directed movement of one of the cells.

cell-matrix adhesion involved in mesendodermal cell migration
type: Class
subclass of: cell-matrix adhesion involved in ameboidal cell migration
subclass of: part-of-parent-90134
IAO_0000115: The binding of a cell to the extracellular matrix that contributes to the directed movement of a mesendodermal cell.

establishment of cell polarity involved in mesendodermal cell migration
type: Class
subclass of: establishment of cell polarity involved in gastrulation cell migration
subclass of: part-of-parent-90134
IAO_0000115: The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of a mesendodermal cell.

cell-cell adhesion involved in mesendodermal cell migration
type: Class
subclass of: cell-cell adhesion involved in ameboidal cell migration
subclass of: GO_0070586
subclass of: part-of-parent-3369
IAO_0000115: The attachment of mesendodermal cells to each other that contributes to the establishment of cell polarity that is part of the directed movement of the cells of the mesendoderm.

establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration
type: Class
subclass of: GO_0030952
subclass of: part-of-parent-1667
subclass of: part-of-parent-3365
IAO_0000115: Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell.

establishment or maintenance of cytoskeleton polarity involved in mesendodermal cell migration
type: Class
subclass of: establishment or maintenance of cytoskeleton polarity involved in gastrulation
subclass of: part-of-parent-3369
subclass of: part-of-parent-90134
IAO_0000115: Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating mesendodermal cell.

dynamin family protein polymerization involved in membrane fission
type: Class
subclass of: GO_0051258
subclass of: part-of-parent-90148
IAO_0000115: The process of creating dynamin family protein polymers, compounds composed of a large number of dynamin family protein monomers. Dynamin family protein polymers form around lipid tubes and contribute to membrane fission.

dynamin family protein polymerization involved in mitochondrial fission
type: Class
subclass of: dynamin family protein polymerization involved in membrane fission
IAO_0000115: The process of creating dynamin protein family polymers, compounds composed of a large number of dynamin family monomers around a lipid tube of a dividing mitochondrion. Dynamin polymers form around lipid tubes and contribute to membrane fission.

regulation of dynamin family protein polymerization involved in membrane fission
type: Class
subclass of: GO_0032271
IAO_0000115: Any process that modulates the rate, frequency, or extent of dynamin family protein polymerization involved in mitochondrial fission.

sphingosine-1-phosphate receptor signaling pathway
type: Class
subclass of: GO_0007186
subclass of: GO_0090520
IAO_0000115: A G protein-coupled receptor signaling pathway initiated by sphingosine-1-phosphate binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
has exact synonym: S1P-activated GPCR signaling pathway
has exact synonym: S1P-activated G-protein coupled receptor signaling pathway
has exact synonym: S1P receptor signaling pathway
has related synonym: S1P signaling pathway
has exact synonym: S1P-stimulated signal transduction pathway
has related synonym: sphingolipid signaling pathway
has related synonym: sphingolipid signalling pathway
replaces: GO_0001789

obsolete regulation of apoptosis by sphingosine-1-phosphate signaling pathway
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of apoptosis.

obsolete regulation of inflammatory response by sphingosine-1-phosphate signaling pathway
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of the inflammatory response.

establishment of cell polarity involved in gastrulation cell migration
type: Class
subclass of: establishment of cell polarity involved in ameboidal cell migration
subclass of: part-of-parent-42074
IAO_0000115: The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation.

establishment or maintenance of cytoskeleton polarity involved in gastrulation
type: Class
subclass of: establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration
subclass of: part-of-parent-3379
subclass of: part-of-parent-7369
IAO_0000115: Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation.

epithelial cell morphogenesis involved in gastrulation
type: Class
subclass of: epithelial cell morphogenesis
subclass of: part-of-parent-7369
IAO_0000115: The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation.

epithelial cell morphogenesis
type: Class
subclass of: cell morphogenesis involved in differentiation
subclass of: part-of-parent-2064
IAO_0000115: The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state.

apical constriction
type: Class
subclass of: GO_0070252
subclass of: part-of-parent-3382
IAO_0000115: The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell.

apical constriction involved in gastrulation
type: Class
subclass of: apical constriction
subclass of: part-of-parent-3381
subclass of: part-of-parent-7369
IAO_0000115: The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell, contributing to the process of gastrulation.

cell-cell signaling involved in amphid sensory organ development
type: Class
subclass of: GO_0007267
subclass of: part-of-parent-3386
IAO_0000115: Any process that mediates the transfer of information from one cell to another and contributes to the progression of an amphid sensory organ over time, from its formation to the mature state.
has exact synonym: cell-cell signalling involved in amphid sensory organ development

amphid sensory organ development
type: Class
subclass of: GO_0007423
IAO_0000115: The progression of the amphid sensory organ over time, from its formation to the mature structure. Amphid sensory organs are the sensory organs of nematodes.

neuron differentiation involved in amphid sensory organ development
type: Class
subclass of: GO_0030182
subclass of: part-of-parent-3386
IAO_0000115: The process in which a relatively unspecialized cell acquires specialized features of a neuron that contributes to the progression of the amphid sensory gland.

neuron development involved in amphid sensory organ development
type: Class
subclass of: GO_0048666
subclass of: part-of-parent-3386
subclass of: part-of-parent-3387
IAO_0000115: The process whose specific outcome is the progression of a neuron over time, that contributes to the development of the amphid sensory organ.

retrograde extension
type: Class
subclass of: GO_0031175
IAO_0000115: The progression of a neuronal projection over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point.

dendrite development by retrograde extension
type: Class
subclass of: retrograde extension
subclass of: GO_0016358
IAO_0000115: The progression of a dendrite over time by the attachment of a part of the neuron to an anchor and the subsequent migration of the cell body away from the anchor point.
has exact synonym: dendrite retrograde extension

amphid sensory organ dendrite retrograde extension
type: Class
subclass of: dendrite development by retrograde extension
subclass of: part-of-parent-3388
IAO_0000115: The progression of an amphid sensory organ's neuronal dendrite over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point.

cell adhesion involved in retrograde extension
type: Class
subclass of: GO_0007155
subclass of: part-of-parent-3389
IAO_0000115: The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension.

neuron migration involved in retrograde extension
type: Class
subclass of: neuron migration
subclass of: part-of-parent-3389
IAO_0000115: The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension.

cell adhesion involved in dendrite retrograde extension
type: Class
subclass of: cell adhesion involved in retrograde extension
subclass of: part-of-parent-3390
IAO_0000115: The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension of a dendrite.

neuron migration involved in dendrite retrograde extension
type: Class
subclass of: neuron migration involved in retrograde extension
subclass of: part-of-parent-3390
IAO_0000115: The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite.

cell adhesion involved in amphid sensory organ dendrite retrograde extension
type: Class
subclass of: cell adhesion involved in dendrite retrograde extension
subclass of: part-of-parent-3391
IAO_0000115: The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite in a neuron of the amphid sensory organ.

neuron migration involved in amphid sensory organ dendrite retrograde extension
type: Class
subclass of: neuron migration involved in dendrite retrograde extension
subclass of: part-of-parent-3391
IAO_0000115: The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite of a neuron in the amphid sensory organ.

glial cell differentiation involved in amphid sensory organ development
type: Class
subclass of: GO_0010001
subclass of: part-of-parent-3386
IAO_0000115: The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the amphid sensory organ.

cytoneme morphogenesis
type: Class
subclass of: GO_0120039
IAO_0000115: The process in which the anatomical structures of a cytoneme are shaped. A cytoneme is a long, thin and polarized actin-based cytoplasmic extension that projects from a cell.

regulation of COPII vesicle coating
type: Class
subclass of: GO_0033043
subclass of: GO_0043254
subclass of: GO_0090113
IAO_0000115: Any process that modulates the rate, frequency, or extent of the addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat.

axis elongation
type: Class
subclass of: GO_0060560
IAO_0000115: The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure.
has related synonym: elongation of an axis

planar cell polarity pathway involved in axis elongation
type: Class
subclass of: GO_0060071
subclass of: part-of-parent-3401
IAO_0000115: The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal to modulate cytoskeletal elements and control cell polarity that contributes to axis elongation.

optic vesicle formation
type: Class
subclass of: GO_0048646
subclass of: part-of-parent-3404
subclass of: part-of-parent-60900
IAO_0000115: The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup.

optic vesicle morphogenesis
type: Class
subclass of: GO_0048598
subclass of: GO_0048729
subclass of: part-of-parent-48596
IAO_0000115: The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup.

optic vesicle elongation
type: Class
subclass of: GO_0060560
subclass of: part-of-parent-3404
IAO_0000115: The developmental growth that results in the lengthening of the optic vesicle in the posterior direction.

retinal pigment epithelium development
type: Class
subclass of: GO_0060429
subclass of: part-of-parent-60041
IAO_0000115: The progression of the retinal pigment epithelium over time, from its initial formation to the mature structure. The retinal pigment epithelium is the melanin-containing layer of cells between the retina and the choroid that absorbs scattered and reflected light and removes waste products produced by the photoreceptor cells.
has related synonym: RPE development

neural retina development
type: Class
subclass of: GO_0048856
subclass of: part-of-parent-60041
IAO_0000115: The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.

optic cup formation involved in camera-type eye development
type: Class
subclass of: GO_0048646
subclass of: part-of-parent-2072
IAO_0000115: The developmental process pertaining to the initial formation of the optic cup, a two-walled vesicle formed from the optic vesicle.

optic cup structural organization
type: Class
subclass of: GO_0048532
subclass of: part-of-parent-2072
IAO_0000115: The process that contributes to creating the structural organization of the optic cup. This process pertains to the physical shaping of the rudimentary structure.
has exact synonym: optic cup structural organisation

anterior rotation of the optic cup
type: Class
subclass of: GO_0048856
subclass of: part-of-parent-43010
IAO_0000115: A 90 degree-rotation of the optic cup resulting in its alignment with the anterior-posterior body axis.

cell motility involved in camera-type eye morphogenesis
type: Class
subclass of: GO_0048870
subclass of: part-of-parent-48593
IAO_0000115: Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye.

establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis
type: Class
subclass of: GO_0045198
subclass of: part-of-parent-48593
IAO_0000115: The specification and formation of the apicobasal polarity of an epithelial cell that contributes to the shaping of a camera-type eye.

chondrocyte differentiation involved in endochondral bone morphogenesis
type: Class
subclass of: chondrocyte differentiation
subclass of: part-of-parent-60350
subclass of: part-of-parent-60351
IAO_0000115: The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage.

chondrocyte morphogenesis involved in endochondral bone morphogenesis
type: Class
subclass of: GO_0090171
subclass of: part-of-parent-3433
subclass of: part-of-parent-60350
IAO_0000115: The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized.

chondrocyte hypertrophy
type: Class
subclass of: GO_0048588
subclass of: part-of-parent-2063
IAO_0000115: The growth of a chondrocyte, where growth contributes to the progression of the chondrocyte over time.

endochondral bone growth
type: Class
subclass of: GO_0098868
IAO_0000115: The increase in size or mass of an endochondral bone that contributes to the shaping of the bone.

growth plate cartilage development
type: Class
subclass of: GO_0060351
subclass of: GO_0061448
subclass of: part-of-parent-3416
IAO_0000115: The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow.

growth plate cartilage chondrocyte differentiation
type: Class
subclass of: chondrocyte differentiation involved in endochondral bone morphogenesis
subclass of: part-of-parent-3417
IAO_0000115: The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage.

growth plate cartilage chondrocyte proliferation
type: Class
subclass of: GO_0008283
subclass of: part-of-parent-3417
IAO_0000115: The multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population.

regulation of growth plate cartilage chondrocyte proliferation
type: Class
subclass of: GO_0042127
IAO_0000115: Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population.

growth plate cartilage axis specification
type: Class
subclass of: GO_0009798
subclass of: part-of-parent-3422
IAO_0000115: The establishment, maintenance and elaboration of the columnar cartilage along the axis of a long bone that contributes to bone growth.
has related synonym: growth plate cartilage axis determination

growth plate cartilage morphogenesis
type: Class
subclass of: GO_0060536
subclass of: part-of-parent-3417
IAO_0000115: The process in which the anatomical structures of growth plate cartilage are generated and organized.

growth plate cartilage chondrocyte division
type: Class
subclass of: GO_0051301
subclass of: part-of-parent-3419
IAO_0000115: The process resulting in the oriented physical partitioning and separation of a chondrocytes in the growth plate.

establishment of cell polarity involved in growth plate cartilage chondrocyte division
type: Class
subclass of: establishment of planar polarity
subclass of: GO_0030010
subclass of: part-of-parent-3423
IAO_0000115: The cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization that results in the directional division of a growth plate cartilage chondrocyte.
has related synonym: growth plate cartilage chondrocyte polarization

establishment of mitotic spindle orientation involved in growth plate cartilage chondrocyte division
type: Class
subclass of: establishment of mitotic spindle orientation
subclass of: cytoskeleton polarization involved in growth plate cartilage chondrocyte division
subclass of: GO_0090176
subclass of: part-of-parent-3423
IAO_0000115: A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures and contributes to oriented chondrocyte division in the growth plate.

cytoskeleton polarization involved in growth plate cartilage chondrocyte division
type: Class
subclass of: GO_0030952
subclass of: part-of-parent-3424
IAO_0000115: A process that is carried out at the cellular level which results in the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell.

regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division
type: Class
subclass of: GO_0032878
subclass of: GO_0051493
subclass of: GO_0060071
IAO_0000115: The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell that modulates the rate, frequency, or extent of the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell.
has exact synonym: regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division by planar cell polarity pathway

chondrocyte intercalation involved in growth plate cartilage morphogenesis
type: Class
subclass of: GO_0016477
subclass of: part-of-parent-3422
subclass of: part-of-parent-60029
IAO_0000115: The orderly movement of a chondrocyte from one site to another that contributes to the shaping of growth plate cartilage in an endochondral bone.

growth plate cartilage chondrocyte morphogenesis
type: Class
subclass of: chondrocyte morphogenesis involved in endochondral bone morphogenesis
subclass of: growth plate cartilage morphogenesis
subclass of: part-of-parent-3418
IAO_0000115: The process in which the structures of a chondrocyte in the growth plate cartilage are generated and organized.

growth plate cartilage chondrocyte growth
type: Class
subclass of: chondrocyte hypertrophy
subclass of: GO_0060560
subclass of: part-of-parent-3431
IAO_0000115: The growth of a growth plate cartilage chondrocyte, where growth contributes to the progression of the chondrocyte over time from one condition to another.
has exact synonym: growth plate cartilage chondrocyte hypertrophy

growth plate cartilage chondrocyte development
type: Class
subclass of: chondrocyte development involved in endochondral bone morphogenesis
subclass of: part-of-parent-3418
IAO_0000115: The progression of a growth plate cartilage chondrocyte over time from after its fate commitment to the mature cell.

cell growth involved in growth plate cartilage chondrocyte morphogenesis
type: Class
subclass of: growth plate cartilage chondrocyte growth
subclass of: part-of-parent-3429
IAO_0000115: The growth of a growth plate cartilage chondrocyte, where growth contributes to the shaping of the chondrocyte over time.

chondrocyte development involved in endochondral bone morphogenesis
type: Class
subclass of: chondrocyte development
subclass of: part-of-parent-3413
subclass of: part-of-parent-60350
IAO_0000115: The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone.

BMP signaling pathway involved in growth plate cartilage chondrocyte development
type: Class
subclass of: GO_0030509
subclass of: part-of-parent-3431
IAO_0000115: The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of a growth plate cartilage chondrocyte over time.
has exact synonym: BMP signalling pathway involved in growth plate cartilage chondrocyte development

smoothened signaling pathway involved in growth plate cartilage chondrocyte development
type: Class
subclass of: GO_0007224
subclass of: part-of-parent-3431
IAO_0000115: The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that contributes to the progression of a growth plate cartilage chondrocyte over time.
has exact synonym: hedgehog signaling pathway involved in growth plate cartilage chondrocyte development
has exact synonym: hh signaling pathway involved in growth plate cartilage chondrocyte development
has exact synonym: smoothened signalling pathway involved in growth plate cartilage chondrocyte development

regulation of cell adhesion involved in growth plate cartilage morphogenesis
type: Class
subclass of: GO_0030155
subclass of: part-of-parent-3422
IAO_0000115: Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix and contributes to the shaping of the growth plate cartilage of an endochondral bone.

regulation of cell communication involved in growth plate cartilage morphogenesis
type: Class
subclass of: GO_0010646
subclass of: part-of-parent-3422
IAO_0000115: Any process that modulates the frequency, rate or extent of cell communication that contributes to the shaping of the growth plate cartilage.

obsolete Gene_Ontology
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A controlled vocabulary that can be applied to all organisms even as knowledge of gene and protein roles in cells is accumulating and changing. GO provides three structured networks of defined terms to describe gene product attributes.

molecular_function
type: Class
IAO_0000115: A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process.
has exact synonym: molecular function
replaces: GO_0005554

obsolete protein
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

nucleic acid binding
type: Class
subclass of: GO_0097159
subclass of: GO_1901363
IAO_0000115: Binding to a nucleic acid.
has related synonym: base pairing
replaces: GO_0000496

DNA binding
type: Class
subclass of: nucleic acid binding
IAO_0000115: Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
has related synonym: microtubule/chromatin interaction
has related synonym: plasmid binding
has related synonym: structure specific DNA binding
has related synonym: structure-specific DNA binding
replaces: GO_0043566

DNA helicase activity
type: Class
subclass of: helicase activity
subclass of: GO_0008094
subclass of: part-of-parent-32508
IAO_0000115: Unwinding of a DNA helix, driven by ATP hydrolysis.
has exact synonym: ATP-dependent DNA helicase activity
replaces: GO_0003679
replaces: GO_0004003

minor groove of adenine-thymine-rich DNA binding
type: Class
subclass of: DNA secondary structure binding
IAO_0000115: Binding to a DNA structure formed by the minor groove of adenine-thymine-rich DNA regions. Examples of proteins having this function are AT-rich interaction domain (ARID)-containing proteins.
has exact synonym: AT binding
has exact synonym: AT DNA binding
has exact synonym: AT-rich DNA binding

bent DNA binding
type: Class
subclass of: DNA binding
IAO_0000115: Binding to DNA in a bent conformation.

chromatin binding
type: Class
subclass of: GO_0005488
IAO_0000115: Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
has related synonym: lamin/chromatin binding
has related synonym: microtubule/chromatin interaction
has related synonym: nuclear membrane vesicle binding to chromatin

obsolete lamin/chromatin binding
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

damaged DNA binding
type: Class
subclass of: DNA binding
IAO_0000115: Binding to damaged DNA.
has related synonym: DNA repair enzyme
has related synonym: DNA repair protein

obsolete DNA repair protein
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete DNA repair enzyme
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete DNA replication factor
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

DNA replication origin binding
type: Class
subclass of: GO_1990837
IAO_0000115: Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.
has related synonym: ARS binding

DNA clamp loader activity
type: Class
subclass of: GO_0008094
IAO_0000115: Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex, driven by ATP hydrolysis.
has exact synonym: DNA clamp loading ATPase activity
has related synonym: DNA-protein loading ATPase activity
has related synonym: PCNA loading activity
has related synonym: PCNA loading complex activity
has related synonym: protein-DNA loading ATPase activity
replaces: GO_0033170

double-stranded DNA binding
type: Class
subclass of: DNA binding
IAO_0000115: Binding to double-stranded DNA.
has exact synonym: dsDNA binding

double-stranded telomeric DNA binding
type: Class
subclass of: double-stranded DNA binding
subclass of: GO_0042162
IAO_0000115: Binding to double-stranded telomere-associated DNA.

left-handed Z-DNA binding
type: Class
subclass of: double-stranded DNA binding
IAO_0000115: Binding to DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags.

P-element binding
type: Class
subclass of: GO_1990837
IAO_0000115: Binding to a P-element, a class of Drosophila transposon responsible for hybrid dysgenesis.

obsolete plasmid binding
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Interacting selectively with a plasmid, an extrachromosomal genetic element usually characterized as a covalently continuous double stranded DNA molecule found in bacteria and some other microorganisms.

obsolete random coil DNA binding
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Binding to DNA in a random coil configuration.
replaces: GO_0016017

satellite DNA binding
type: Class
subclass of: GO_1990837
IAO_0000115: Binding to satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA.

single-stranded DNA binding
type: Class
subclass of: DNA binding
IAO_0000115: Binding to single-stranded DNA.
has exact synonym: ssDNA binding
replaces: GO_0003698
replaces: GO_0003699

DNA-binding transcription factor activity
type: Class
subclass of: GO_0140110
subclass of: part-of-parent-6355
IAO_0000115: A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
has related synonym: bacterial-type DNA binding transcription factor activity
has related synonym: bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity
has related synonym: bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity
has related synonym: bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
has related synonym: bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding
has exact synonym: DNA binding transcription factor activity
has exact synonym: gene-specific transcription factor activity
has related synonym: metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
has related synonym: metal ion regulated sequence-specific DNA binding transcription factor activity
has related synonym: nucleic acid binding transcription factor activity
has related synonym: sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
has exact synonym: sequence-specific DNA binding transcription factor activity
has related synonym: transcription factor activity
has related synonym: transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding
has related synonym: transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding
has related synonym: transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding
has related synonym: transcription factor activity, metal ion regulated sequence-specific DNA binding
replaces: GO_0000130
replaces: GO_0001071
replaces: GO_0001130
replaces: GO_0001131
replaces: GO_0001151
replaces: GO_0001199
replaces: GO_0001204

obsolete RNA polymerase I transcription factor activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Functions to initiate or regulate RNA polymerase I transcription.

obsolete RNA polymerase II transcription factor activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Functions to initiate or regulate RNA polymerase II transcription.

obsolete specific RNA polymerase II transcription factor activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II.

obsolete ligand-regulated transcription factor activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II in response to a ligand.

nuclear steroid receptor activity
type: Class
subclass of: GO_0038023
subclass of: part-of-parent-43401
IAO_0000115: Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function.
has related synonym: steroid hormone receptor activity

obsolete RNA polymerase III transcription factor activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Functions to initiate or regulate RNA polymerase III transcription.

transcription elongation factor activity
type: Class
subclass of: GO_0140110
IAO_0000115: A molecular function that stimulates the elongation properties of the RNA polymerase during the elongation phase of transcription. A subclass of transcription elongation factors enable the transition from transcription initiation to elongation, while another class rescue stalled RNA polymerases.
has related synonym: transcriptional elongation regulator activity
has related synonym: transcription elongation regulator activity

transcription coregulator activity
type: Class
subclass of: GO_0140110
IAO_0000115: A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.
has related synonym: RNA polymerase II transcriptional cofactor activity
has exact synonym: transcriptional co-regulator
has exact synonym: transcription cofactor activity
replaces: GO_0001104
replaces: GO_0016455

transcription coactivator activity
type: Class
subclass of: transcription coregulator activity
subclass of: part-of-parent-45893
IAO_0000115: A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.
has related synonym: RNA polymerase II transcription coactivator activity
has related synonym: RNA polymerase II transcription co-activator activity
has related synonym: RNA polymerase II transcription mediator activity
has exact synonym: transcription co-activator activity
replaces: GO_0001105

transcription corepressor activity
type: Class
subclass of: transcription coregulator activity
subclass of: part-of-parent-45892
IAO_0000115: A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.
has related synonym: RNA polymerase II transcription corepressor activity
has related synonym: RNA polymerase II transcription co-repressor activity
has exact synonym: transcription co-repressor activity
replaces: GO_0001106

obsolete transcription termination factor activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any activity that brings about termination of transcription.

obsolete RNA polymerase I transcription termination factor activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase I.

obsolete RNA polymerase II transcription termination factor activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase II.

obsolete RNA polymerase III transcription termination factor activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase III.

obsolete transcription factor binding, cytoplasmic sequestering
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

telomerase activity
type: Class
subclass of: RNA-directed DNA polymerase activity
IAO_0000115: Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence.

telomerase RNA reverse transcriptase activity
type: Class
subclass of: RNA-directed DNA polymerase activity
subclass of: part-of-parent-3720
IAO_0000115: Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template.
has exact synonym: telomerase, catalyst

RNA binding
type: Class
subclass of: nucleic acid binding
IAO_0000115: Binding to an RNA molecule or a portion thereof.
has related synonym: base pairing with RNA
has related synonym: poly(A) RNA binding
has related synonym: poly(A)-RNA binding
has related synonym: poly-A RNA binding
replaces: GO_0000498
replaces: GO_0044822

RNA helicase activity
type: Class
subclass of: helicase activity
subclass of: GO_0008186
subclass of: GO_0140098
IAO_0000115: Unwinding of an RNA helix, driven by ATP hydrolysis.
has exact synonym: ATP-dependent RNA helicase activity
replaces: GO_0004004

double-stranded RNA binding
type: Class
subclass of: RNA binding
IAO_0000115: Binding to double-stranded RNA.
has exact synonym: dsRNA binding

double-stranded RNA adenosine deaminase activity
type: Class
subclass of: adenosine deaminase activity
IAO_0000115: Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule.
has related synonym: double-stranded RNA specific editase activity
replaces: GO_0003971

single-stranded RNA binding
type: Class
subclass of: RNA binding
IAO_0000115: Binding to single-stranded RNA.
has exact synonym: ssRNA binding
replaces: GO_0003728

mRNA binding
type: Class
subclass of: RNA binding
IAO_0000115: Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
has related synonym: base pairing with mRNA
replaces: GO_0000499

mRNA 3'-UTR binding
type: Class
subclass of: mRNA binding
IAO_0000115: Binding to a 3' untranslated region of an mRNA molecule.
has exact synonym: mRNA 3' UTR binding

obsolete mRNA cap binding
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Interacting selectively with the 7-methylguanosine cap at the 5' end of a nascent messenger RNA transcript.

obsolete snRNA cap binding
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Interacting selectively with the cap structure at the 5' end of a small nuclear RNA molecule.

obsolete ribonucleoprotein
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete small nuclear ribonucleoprotein
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

structural constituent of ribosome
type: Class
subclass of: GO_0005198
IAO_0000115: The action of a molecule that contributes to the structural integrity of the ribosome.
has related synonym: ribosomal protein
has related synonym: ribosomal RNA
replaces: GO_0003736
replaces: GO_0003737
replaces: GO_0003738
replaces: GO_0003739
replaces: GO_0003740
replaces: GO_0003741
replaces: GO_0003742

translation initiation factor activity
type: Class
subclass of: GO_0008135
subclass of: part-of-parent-6413
IAO_0000115: Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
replaces: GO_0003744
replaces: GO_0003745

translation elongation factor activity
type: Class
subclass of: GO_0008135
subclass of: part-of-parent-6414
IAO_0000115: Functions in chain elongation during polypeptide synthesis at the ribosome.
replaces: GO_0008182
replaces: GO_0008183

translation release factor activity
type: Class
subclass of: GO_0008079
IAO_0000115: Involved in catalyzing the release of a nascent polypeptide chain from a ribosome.
replaces: GO_0003748
replaces: GO_0003749

obsolete cell cycle regulator
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete chaperone activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Assists in the correct non-covalent assembly of polypeptide-containing structures in vivo, but is not a component of these assembled structures when they are performing their normal biological function.
replaces: GO_0003757
replaces: GO_0003758
replaces: GO_0003760
replaces: GO_0003761

peptidyl-prolyl cis-trans isomerase activity
type: Class
subclass of: GO_0016859
subclass of: GO_0140096
IAO_0000115: Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
has exact synonym: cis-trans proline isomerase activity
has related synonym: cyclophilin activity
has related synonym: cyclophilin-type peptidyl-prolyl cis-trans isomerase activity
has related synonym: FK506-sensitive peptidyl-prolyl cis-trans isomerase
has related synonym: immunophilin
has related synonym: juglone-sensitive cis-trans proline isomerase activity
has related synonym: juglone-sensitive peptidyl-prolyl cis-trans isomerase activity
has related synonym: parvulin
has related synonym: peptide bond isomerase activity
has related synonym: peptidylproline cis-trans-isomerase activity
has related synonym: peptidylprolyl cis-trans isomerase activity
has related synonym: peptidylprolyl isomerase activity
has related synonym: peptidyl-prolyl isomerase B reaction
has related synonym: PPIase activity
has related synonym: rotamase activity
replaces: GO_0004752
replaces: GO_0042028

protein disulfide isomerase activity
type: Class
subclass of: GO_0016864
subclass of: GO_0140096
IAO_0000115: Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.
has exact synonym: disulphide bond biosynthesis
has exact synonym: disulphide bond formation
has related synonym: protein cysteine-thiol oxidation
has related synonym: protein disulfide-isomerase
has related synonym: protein disulfide-isomerase reaction
has exact synonym: protein disulphide isomerase activity
has exact synonym: protein thiol-disulfide exchange
has exact synonym: protein thiol-disulphide exchange
has related synonym: S-S rearrangase activity
replaces: GO_0006467

obsolete glycoprotein-specific chaperone activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Assists in the correct, non-covalent assembly of glycoproteins in vivo, but is not a component of the assembled structures when performing its normal biological function. Utilizes a lectin site as a means to associate with the unfolded glycoproteins.

obsolete histone-specific chaperone activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Assists in chromatin assembly by chaperoning histones on to replicating DNA, but is not a component of the assembled nucleosome when performing its normal biological function.

obsolete chaperonin ATPase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts.
replaces: GO_0003764
replaces: GO_0003765
replaces: GO_0003766

obsolete co-chaperone activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Co-chaperones are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperones by themselves do not possess chaperone activity.
replaces: GO_0003768
replaces: GO_0003769
replaces: GO_0003770
replaces: GO_0003771

obsolete co-chaperonin activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Co-chaperonins are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperonins by themselves do not possess chaperone activity.

obsolete heat shock protein activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any of a group of specific proteins that are synthesized by both prokaryotic and eukaryotic cells after they have been exposed to a temperature that is higher than normal. Other stresses, e.g. free radical damage, have a similar effect. Many members of the hsp family are not induced but are present in all cells. They are characterized by their role as molecular chaperones.

cytoskeletal motor activity
type: Class
subclass of: molecular_function
IAO_0000115: Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force).
has related synonym: motor activity

obsolete axonemal motor activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete muscle motor activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

microtubule motor activity
type: Class
subclass of: cytoskeletal motor activity
subclass of: GO_0140657
IAO_0000115: A motor activity that generates movement along a microtubule, driven by ATP hydrolysis.
has exact synonym: ATP-dependent microtubule motor activity
has related synonym: axonemal motor activity
has related synonym: dynein
has related synonym: dynein ATPase activity
has related synonym: kinesin
has related synonym: kinesin motor activity
has related synonym: kinetochore motor activity
replaces: GO_1990939

obsolete dynactin motor
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

actin binding
type: Class
subclass of: GO_0008092
IAO_0000115: Binding to monomeric or multimeric forms of actin, including actin filaments.
has related synonym: membrane associated actin binding

obsolete actin cross-linking activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Interacting selectively with two actin filaments to anchor them together.

obsolete actin bundling activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete F-actin capping activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete barbed-end actin capping activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete barbed-end actin capping/severing activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

actin monomer binding
type: Class
subclass of: actin binding
IAO_0000115: Binding to monomeric actin, also known as G-actin.
has exact synonym: G actin binding

actin lateral binding
type: Class
subclass of: GO_0051015
IAO_0000115: Binding to an actin filament along its length.

obsolete actin depolymerizing activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete actin monomer sequestering activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

actin filament severing activity
type: Class
subclass of: GO_0140776
subclass of: part-of-parent-30036
IAO_0000115: Binding to an actin subunit and promoting its dissociation from an actin filament by a local change in actin subunit conformation and orientation, and severing of filaments.
has exact synonym: actin depolymerizing activity

obsolete actin modulating activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete membrane associated actin binding
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete regulation of actin thin filament length activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete defense/immunity protein activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any activity that plays a role in the defense/immune response of an organism against infection and disease.

obsolete acute-phase response protein activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete antimicrobial peptide activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Inhibits the growth of, or directly kills, microbial cells.

lysozyme activity
type: Class
subclass of: hydrolase activity, hydrolyzing O-glycosyl compounds
subclass of: GO_0061783
IAO_0000115: Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan.
has exact synonym: 1,4-N-acetylmuramidase activity
has related synonym: globulin G
has related synonym: globulin G1
has related synonym: L-7001
has related synonym: lysozyme g
has exact synonym: mucopeptide glucohydrolase activity
has exact synonym: mucopeptide N-acetylmuramoylhydrolase activity
has exact synonym: muramidase activity
has exact synonym: N,O-diacetylmuramidase activity
has related synonym: peptidoglycan N-acetylmuramoylhydrolase activity
has related synonym: PR1-lysozyme

obsolete antibacterial peptide activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells.

obsolete male-specific antibacterial peptide activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells, but which is only expressed in males.

obsolete antifungal peptide activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Inhibits the growth of, or directly kills, fungal cells.

obsolete antiviral response protein activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A protein involved in an antiviral response.

obsolete blood coagulation factor activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete coagulation factor VIIa activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the selective cleavage of one Arg-Ile bond in factor X to form factor Xa, and on factor IX to form factor IXa beta.

obsolete coagulation factor IXa activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the selective cleavage of the Arg-Ile bond in factor X to form factor Xa.

obsolete coagulation factor Xa activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of Arg-Thr and then Arg-Ile bonds in prothrombin to form thrombin, and on factor VII, which it converts to a two-chain form (factor VIIa).

obsolete coagulation factor XIa activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the selective cleavage of Arg-Ala and Arg-Val bonds in factor IX to form factor IXa.

obsolete coagulation factor XIIa activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the selective cleavage of Arg-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa.

obsolete plasma kallikrein activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the selective cleavage of Arg-Xaa and Lys-Xaa bonds, including Lys-Arg and Arg-Ser bonds in (human) kininogen to release bradykinin.

obsolete protein C (activated) activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the degradation of blood coagulation factors Va and VIIIa.

obsolete thrombin activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B.

protein-glutamine gamma-glutamyltransferase activity
type: Class
subclass of: GO_0016755
IAO_0000115: Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
has related synonym: factor XIIIa
has exact synonym: fibrinoligase activity
has related synonym: fibrin stabilizing factor
has related synonym: glutaminylpeptide gamma-glutamyltransferase activity
has related synonym: polyamine transglutaminase activity
has related synonym: protein-glutamine:amine gamma-glutamyltransferase
has related synonym: R-glutaminyl-peptide:amine gamma-glutamyl transferase activity
has exact synonym: TGase activity
has related synonym: tissue transglutaminase
has exact synonym: transglutaminase activity

obsolete complement activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Any of a set of activities involved in the complement cascade.

obsolete alternative-complement-pathway C3/C5 convertase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg bond in complement component C5 alpha-chain to yield C5a and C5b.

obsolete classical-complement-pathway C3/C5 convertase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the selective cleavage of Arg-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg bond in complement component C5 alpha-chain to form C5a and C5b.

obsolete complement component C1r activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the selective cleavage of Lys(or Arg)-Ile bond in complement subcomponent C1s to form the active form of C1s (EC:3.4.21.42).

obsolete complement component C1s activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the cleavage of component C4 to C4a and C4b (Arg-Ala bond), and component C2 to C2a and C2b (Lys-Lys or Arg-Lys bond).

obsolete complement factor D activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the cleavage of component factor B (Arg-Lys) when in complex with C3b or with cobra venom factor (CVF).

obsolete complement factor I activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the inactivation of complement subcomponents C3b, iC3b and C4b by proteolytic cleavage.

obsolete major histocompatibility complex antigen
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete class I major histocompatibility complex antigen
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete class II major histocompatibility complex antigen
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete MHC-interacting protein
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

antigen binding
type: Class
subclass of: GO_0005488
IAO_0000115: Binding to an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen.
has related synonym: antibody
has related synonym: B cell receptor activity
has related synonym: immunoglobulin
has related synonym: opsonin activity

catalytic activity
type: Class
subclass of: molecular_function
IAO_0000115: Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
has exact synonym: enzyme activity

alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
type: Class
subclass of: GO_0035251
IAO_0000115: Catalysis of the reaction: UDP-glucose + D-glucose-6-phosphate = UDP + alpha,alpha-trehalose-6-phosphate.
has related synonym: alpha,alpha-trehalose phosphate synthase (UDP-forming)
has related synonym: phosphotrehalose-uridine diphosphate transglucosylase activity
has exact synonym: transglucosylase activity
has exact synonym: trehalose 6-phosphate synthase activity
has exact synonym: trehalose 6-phosphate synthetase activity
has related synonym: trehalose phosphate synthase activity
has exact synonym: trehalose-phosphate synthase activity
has related synonym: trehalose phosphate synthetase activity
has exact synonym: trehalose-phosphate synthetase activity
has exact synonym: trehalosephosphate-UDP glucosyltransferase activity
has exact synonym: trehalosephosphate-UDP glucosyl transferase activity
has related synonym: trehalose phosphate-uridine diphosphate glucosyltransferase activity
has related synonym: trehalose-P synthetase activity
has related synonym: UDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity
has exact synonym: UDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity
has related synonym: UDPglucose-glucose-phosphate glucosyltransferase activity
has related synonym: UDP-glucose-glucosephosphate glucosyltransferase activity
has exact synonym: UDP-glucose-glucose-phosphate glucosyltransferase activity
has related synonym: uridine diphosphoglucose phosphate glucosyltransferase activity

alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
type: Class
subclass of: GO_0008375
subclass of: GO_0140103
IAO_0000115: Catalysis of the reaction: 3-(alpha-D-mannosyl)-beta-D-mannosyl-R + UDP-N-acetyl-alpha-D-glucosamine = 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R + H(+) + UDP.
has related synonym: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity
has exact synonym: alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity
has related synonym: alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity
has related synonym: GnTI
has related synonym: GNTI activity
has related synonym: N-acetylglucosaminyltransferase I activity
has related synonym: N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity
has related synonym: UDP-N-acetyl-D-glucosamine:3-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity
has related synonym: UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I activity
has related synonym: UDP-N-acetylglucosaminyl:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I activity
has related synonym: uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity

alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
type: Class
subclass of: GO_0008373
IAO_0000115: Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R.
has related synonym: alpha-2,8-sialyltransferase activity
has exact synonym: alpha-N-acetylneuraminide alpha-2,8-sialyltransferase activity
has related synonym: CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-2,3-beta-D-galactoside alpha-2,8-N-acetylneuraminyltransferase activity
has related synonym: CMP-NeuAc:LM1(alpha-2,8) sialyltranferase activity
has related synonym: CMP-NeuAc:LM1 alpha-(2->8)-sialyltranferase activity
has related synonym: cytidine monophosphoacetylneuraminate-ganglioside GM3
has related synonym: ganglioside GD3 synthase activity
has related synonym: ganglioside GD3 synthetase sialyltransferase activity
has related synonym: GD3 synthase activity
has related synonym: SAT-2

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
type: Class
subclass of: GO_0008375
subclass of: GO_0140103
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R.
has related synonym: beta(6)-N-acetylglucosaminyltransferase activity
has related synonym: beta6-N-acetylglucosaminyltransferase activity
has related synonym: core 2 acetylglucosaminyltransferase activity
has related synonym: core 6-beta-GlcNAc-transferase A
has related synonym: O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity
has related synonym: UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity
has related synonym: uridine diphosphoacetylglucosamine-mucin beta-(1,6)-acetylglucosaminyltransferase activity
has related synonym: uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase activity

beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
type: Class
subclass of: GO_0008375
subclass of: GO_0140103
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R.
has related synonym: beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity
has related synonym: beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity
has related synonym: GnTIII activity
has related synonym: N-acetylglucosaminyltransferase III activity
has related synonym: N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity
has related synonym: UDP-N-acetyl-D-glucosamine:beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity
has related synonym: uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III
has related synonym: uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase III activity

beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
type: Class
subclass of: GO_0035250
IAO_0000115: Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide.
has related synonym: beta-N-acetyl-beta-(1,4)-galactosyltransferase activity
has related synonym: beta-N-acetyl-beta-1,4-galactosyltransferase activity
has related synonym: GalT activity
has related synonym: glycoprotein 4-beta-galactosyltransferase activity
has related synonym: glycoprotein 4-beta-galactosyl-transferase activity
has related synonym: glycoprotein beta-galactosyltransferase activity
has related synonym: thyroid galactosyltransferase activity
has related synonym: thyroid glycoprotein beta-galactosyltransferase
has related synonym: UDPgalactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity
has related synonym: UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity
has related synonym: UDPgalactose-glycoprotein galactosyltransferase activity
has related synonym: UDP-galactose--glycoprotein galactosyltransferase activity
has related synonym: uridine diphosphogalactose-glycoprotein galactosyltransferase activity

beta-alanyl-dopamine hydrolase activity
type: Class
subclass of: GO_0016787
IAO_0000115: Catalysis of the reaction: N-beta-alanyl dopamine + H2O = dopamine + beta-alanine.
has exact synonym: NBAD hydrolase activity
has exact synonym: N-beta-alanyl-dopamine hydrolase activity

beta-alanyl amine synthase activity
type: Class
subclass of: GO_0016879
IAO_0000115: Catalysis of the synthesis of beta-alanyl amine conjugate from a precursor biogenic amine, such as dopamine or histamine.
has related synonym: beta-alanyl-dopamine synthase activity
has exact synonym: NBAD transferase activity
has exact synonym: N-beta-alanyl dopamine synthetase activity

beta-carotene 15,15'-dioxygenase activity
type: Class
subclass of: GO_0016702
IAO_0000115: Catalysis of the reaction: all-trans-beta-carotene + O2 = 2 all-trans-retinal.
has related synonym: beta-carotene 15,15'-monooxygenase activity
has related synonym: carotene 15,15'-dioxygenase activity
has related synonym: carotene dioxygenase activity

beta-galactoside alpha-2,6-sialyltransferase activity
type: Class
subclass of: GO_0008373
IAO_0000115: Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine.
has exact synonym: beta-galactosamide alpha-2,6-sialyltransferase activity
has related synonym: CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine alpha-2,6-N-acetylneuraminyltransferase activity
has related synonym: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase activity

beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
type: Class
subclass of: GO_0008373
IAO_0000115: Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R.
has related synonym: CMP-N-acetylneuraminate:beta-D-galactoside alpha-2,3-N-acetylneuraminyl-transferase activity
has related synonym: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase activity

beta-ureidopropionase activity
type: Class
subclass of: GO_0016811
IAO_0000115: Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3.
has related synonym: N-carbamoyl-beta-alanine amidohydrolase activity

sterol 24-C-methyltransferase activity
type: Class
subclass of: GO_0008169
subclass of: GO_0008757
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + 5-alpha-cholest-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.
has related synonym: 24-sterol C-methyltransferase activity
has related synonym: delta(24)-methyltransferase activity
has exact synonym: delta(24)-sterol C-methyltransferase activity
has related synonym: delta(24)-sterol methyltransferase activity
has related synonym: delta24-methyltransferase activity
has related synonym: delta24-sterol methyltransferase activity
has related synonym: phytosterol methyltransferase activity
has related synonym: S-adenosyl-4-methionine:sterol Delta(24)-methyltransferase activity
has related synonym: S-adenosyl-4-methionine:sterol delta24-methyltransferase activity
has related synonym: S-adenosyl-L-methionine:Delta(24(23))-sterol methyltransferase activity
has related synonym: S-adenosyl-L-methionine:Delta24(23)-sterol methyltransferase activity
has related synonym: S-adenosyl-L-methionine:zymosterol 24-C-methyltransferase activity
has related synonym: SMT1 activity
has exact synonym: sterol 24C methyltransferase activity
has related synonym: zymosterol-24-methyltransferase activity
replaces: GO_0102101

gamma-glutamylcyclotransferase activity
type: Class
subclass of: GO_0016842
IAO_0000115: Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid.
has exact synonym: (5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing)
has exact synonym: gamma-glutamyl-amino acid cyclotransferase activity
has exact synonym: gamma-L-glutamylcyclotransferase activity
has exact synonym: L-glutamic cyclase activity

obsolete gamma-glutamyltransferase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid.

1-acylglycerol-3-phosphate O-acyltransferase activity
type: Class
subclass of: GO_0016411
subclass of: GO_0042171
IAO_0000115: Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate.
has related synonym: 1-acylglycero-3-phosphate acyltransferase activity
has related synonym: 1-acylglycerolphosphate acyltransferase activity
has related synonym: 1-acylglycerophosphate acyltransferase activity
has related synonym: 1-acyl-sn-glycero-3-phosphate acyltransferase activity
has related synonym: 1-acyl-sn-glycerol 3-phosphate acyltransferase activity
has exact synonym: 1-acyl-sn-glycerol-3-phosphate acyltransferase activity
has related synonym: acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase activity
has exact synonym: lysophosphatidate acyltransferase activity
has related synonym: lysophosphatidic acid-acyltransferase activity
replaces: GO_0004469

1-pyrroline-5-carboxylate dehydrogenase activity
type: Class
subclass of: GO_0016620
IAO_0000115: Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H(+).
has related synonym: 1-pyrroline-5-carboxylate:NAD+ oxidoreductase activity
has related synonym: 1-pyrroline dehydrogenase
has related synonym: delta1-pyrroline-5-carboxylate dehydrogenase activity
has related synonym: L-pyrroline-5-carboxylate-NAD+ oxidoreductase activity
has related synonym: pyrroline-5-carboxylate dehydrogenase activity
has related synonym: pyrroline-5-carboxylic acid dehydrogenase activity

1,3-beta-D-glucan synthase activity
type: Class
subclass of: GO_0035251
IAO_0000115: Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + [(1->3)-beta-D-glucosyl](n+1).
has related synonym: (1,3)-beta-glucan (callose) synthase activity
has related synonym: 1,3-beta-D-glucan synthetase activity
has related synonym: 1,3-beta-D-glucan-UDP glucosyltransferase activity
has related synonym: 1,3-beta-glucan synthase activity
has related synonym: 1,3-beta-glucan-uridine diphosphoglucosyltransferase activity
has exact synonym: beta-1,3-glucan synthase activity
has related synonym: beta-1,3-glucan synthetase activity
has exact synonym: callose synthase activity
has related synonym: callose synthetase activity
has related synonym: GS-II
has related synonym: paramylon synthetase
has related synonym: UDP-glucose:(1,3)beta-glucan synthase activity
has related synonym: UDPglucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity
has related synonym: UDP-glucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity
has related synonym: UDPglucose-1,3-beta-D-glucan glucosyltransferase activity
has related synonym: UDP-glucose-1,3-beta-D-glucan glucosyltransferase activity
has related synonym: UDP-glucose-1,3-beta-glucan glucosyltransferase activity
has related synonym: UDP-glucose-beta-glucan glucosyltransferase activity
has related synonym: uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase activity
replaces: GO_0009981

1,4-alpha-glucan branching enzyme activity
type: Class
subclass of: GO_0016758
IAO_0000115: Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain.
has exact synonym: 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-alpha-D-(1,4-alpha-D-glucano)-transferase activity
has exact synonym: 1,4-glucan-6-(1,4-glucano)-transferase activity
has related synonym: alpha-1,4-glucan:alpha-1,4-glucan-6-glycosyltransferase activity
has related synonym: alpha-glucan-branching glycosyltransferase activity
has related synonym: amylo-(1,4->1,6)-transglycosylase activity
has related synonym: amylo-(1,4 to 1,6)transglucosidase activity
has related synonym: amylose isomerase activity
has related synonym: branching enzyme activity
has related synonym: branching glycosyltransferase activity
has related synonym: enzymatic branching factor
has related synonym: enzyme Q
has related synonym: glucosan transglycosylase activity
has related synonym: glycogen branching enzyme activity
has related synonym: plant branching enzyme
has related synonym: Q-enzyme
has related synonym: starch branching enzyme

11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity
type: Class
subclass of: GO_0033764
IAO_0000115: Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H(+).
has related synonym: 11beta-hydroxysteroid dehydrogenase
has related synonym: 11beta-hydroxy steroid dehydrogenase
has related synonym: beta-hydroxysteroid dehydrogenase
has related synonym: corticosteroid 11beta-dehydrogenase
has related synonym: corticosteroid 11-reductase

2-acylglycerol O-acyltransferase activity
type: Class
subclass of: GO_0016411
IAO_0000115: Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol.
has related synonym: acyl-CoA:2-acylglycerol O-acyltransferase activity
has related synonym: acyl coenzyme A-monoglyceride acyltransferase activity
has related synonym: acylglycerol palmitoyltransferase activity
has related synonym: monoacylglycerol acyltransferase activity
has related synonym: monoglyceride acyltransferase activity

1-alkyl-2-acetylglycerophosphocholine esterase activity
type: Class
subclass of: GO_0052689
IAO_0000115: Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.
has related synonym: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase activity
has related synonym: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase activity
has exact synonym: 2-acetyl-1-alkylglycerophosphocholine esterase activity
has related synonym: alkylacetyl-GPC:acetylhydrolase activity
has related synonym: LDL-associated phospholipase A(2) activity
has related synonym: LDL-associated phospholipase A2
has related synonym: LDL-PLA(2) activity
has related synonym: LDL-PLA2
has related synonym: PAF 2-acylhydrolase activity
has related synonym: PAF acetylhydrolase activity
has related synonym: platelet-activating factor acetylhydrolase activity

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
type: Class
subclass of: GO_0016778
IAO_0000115: Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H(+).
has exact synonym: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity
has related synonym: 6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity
has related synonym: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity
has related synonym: 7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity
has related synonym: 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity
has related synonym: 7,8-dihydroxymethylpterin-pyrophosphokinase activity
has related synonym: ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity
has related synonym: H2-pteridine-CH2OH pyrophosphokinase activity
has related synonym: HPPK
has related synonym: hydroxymethyldihydropteridine pyrophosphokinase activity

3-deoxy-7-phosphoheptulonate synthase activity
type: Class
subclass of: GO_0016765
IAO_0000115: Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate.
has exact synonym: 2-dehydro-3-deoxyphosphoheptonate aldolase activity
has related synonym: 2-dehydro-3-deoxy-phosphoheptonate aldolase activity
has related synonym: 2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase activity
has related synonym: 3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase activity
has related synonym: 3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase activity
has related synonym: 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase activity
has related synonym: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate
has related synonym: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity
has related synonym: 7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity
has related synonym: DAH7-P synthase activity
has related synonym: DAHP synthase activity
has related synonym: deoxy-D-arabino-heptulosonate-7-phosphate synthetase activity
has related synonym: D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) activity
has related synonym: D-erythrose-4-phosphate-lyase activity
has related synonym: DHAP synthase activity
has related synonym: DS-Co activity
has related synonym: DS-Mn activity
has related synonym: KDPH synthase activity
has related synonym: KDPH synthetase activity
has related synonym: phospho-2-dehydro-3-deoxyheptonate aldolase activity
has related synonym: phospho-2-keto-3-deoxyheptanoate aldolase activity
has related synonym: phospho-2-keto-3-deoxyheptonate aldolase activity
has related synonym: phospho-2-keto-3-deoxyheptonic aldolase activity
has related synonym: phospho-2-oxo-3-deoxyheptonate aldolase activity
has related synonym: phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)

2-deoxyglucose-6-phosphatase activity
type: Class
subclass of: GO_0050308
IAO_0000115: Catalysis of the reaction: 2-deoxy-D-glucose-6-phosphate + H2O = 2-deoxy-D-glucose + phosphate.
has related synonym: 2-deoxy-D-glucose-6-phosphate phosphohydrolase activity
has related synonym: 2-deoxyglucose-6-phosphate phosphatase activity

2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity
type: Class
subclass of: GO_0035250
IAO_0000115: Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine.
has related synonym: cerebroside synthase activity
has related synonym: UDPgalactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity
has related synonym: UDP-galactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity
has related synonym: UDPgalactose:2-2-hydroxyacylsphingosine galactosyltransferase activity
has related synonym: UDPgalactose:ceramide galactosyltransferase activity
has related synonym: UDPgalactose-2-hydroxyacylsphingosine galactosyltransferase activity
has related synonym: UDP-galactose-ceramide galactosyltransferase activity
has related synonym: uridine diphosphogalactose-2-hydroxyacylsphingosine galactosyltransferase activity

2-isopropylmalate synthase activity
type: Class
subclass of: GO_0046912
IAO_0000115: Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+).
has related synonym: 3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) activity
has related synonym: acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
has related synonym: alpha-IPM synthetase activity
has related synonym: alpha-isopropylmalate synthase activity
has related synonym: alpha-isopropylmalate synthetase activity
has related synonym: alpha-isopropylmalic synthetase activity
has related synonym: isopropylmalate synthase activity
has related synonym: isopropylmalate synthetase activity

2-methylacyl-CoA dehydrogenase activity
type: Class
subclass of: acyl-CoA dehydrogenase activity
IAO_0000115: Catalysis of the reaction: 2-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein].
has related synonym: 2-methyl branched chain acyl-CoA dehydrogenase activity
has related synonym: 2-methyl-branched-chain-enoyl-CoA reductase activity
has related synonym: branched-chain acyl-CoA dehydrogenase activity
replaces: GO_0047119

3-beta-hydroxy-delta5-steroid dehydrogenase activity
type: Class
subclass of: GO_0033764
IAO_0000115: Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+).
has related synonym: 3beta-HSDH
has related synonym: 3beta-hydroxy-5-ene steroid dehydrogenase activity
has related synonym: 3beta-hydroxy-5-ene-steroid dehydrogenase activity
has related synonym: 3-beta-hydroxy-5-ene steroid dehydrogenase activity
has related synonym: 3beta-hydroxy-5-ene-steroid oxidoreductase activity
has exact synonym: 3-beta-hydroxy-D5-steroid dehydrogenase activity
has related synonym: 3beta-hydroxy-delta5-C27-steroid dehydrogenase/isomerase activity
has related synonym: 3beta-hydroxy-delta5-C27-steroid oxidoreductase
has related synonym: 3beta-hydroxy-delta5-steroid:NAD+ 3-oxidoreductase activity
has related synonym: 3beta-hydroxy-delta5-steroid dehydrogenase activity
has related synonym: 3beta-hydroxy steroid dehydrogenase/isomerase activity
has related synonym: 5-ene-3-beta-hydroxysteroid dehydrogenase activity
has related synonym: delta5-3beta-hydroxysteroid dehydrogenase activity
has related synonym: progesterone reductase activity
has related synonym: steroid-delta5-3beta-ol dehydrogenase activity

3-dehydroquinate dehydratase activity
type: Class
subclass of: GO_0016836
IAO_0000115: Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H(2)O.
has related synonym: 3-dehydroquinase activity
has related synonym: 3-dehydroquinate hydrolase activity
has related synonym: 3-dehydroquinate hydro-lyase (3-dehydroshikimate-forming)
has related synonym: 3-dehydroquinate hydro-lyase activity
has related synonym: 5-dehydroquinase activity
has related synonym: 5-dehydroquinate dehydratase activity
has related synonym: 5-dehydroquinate hydro-lyase activity
has related synonym: dehydroquinase activity
has related synonym: dehydroquinate dehydratase activity
has related synonym: DHQase

3-dehydroquinate synthase activity
type: Class
subclass of: GO_0016838
IAO_0000115: Catalysis of the reaction: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate.

3-hydroxyacyl-CoA dehydrogenase activity
type: Class
subclass of: GO_0016616
IAO_0000115: Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+).
has related synonym: 3-oxoacyl-thioester reductase activity
has related synonym: beta-hydroxyacylcoenzyme A dehydrogenase activity
has related synonym: beta-hydroxyacyl-coenzyme A synthetase activity
has related synonym: beta-hydroxyacyl dehydrogenase activity
has related synonym: beta-hydroxybutyrylcoenzyme A dehydrogenase activity
has related synonym: beta-ketoacyl-CoA reductase
has related synonym: beta-keto-reductase activity
has related synonym: L-3-hydroxyacyl CoA dehydrogenase activity
has related synonym: L-3-hydroxyacyl coenzyme A dehydrogenase activity

3-hydroxybutyrate dehydrogenase activity
type: Class
subclass of: GO_0016616
IAO_0000115: Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH.
has related synonym: D-beta-hydroxybutyrate dehydrogenase activity

3-hydroxybutyryl-CoA dehydratase activity
type: Class
subclass of: GO_0016836
IAO_0000115: Catalysis of the reaction: (R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H(2)O.
has related synonym: (3R)-3-hydroxybutanoyl-CoA hydro-lyase (crotonoyl-CoA-forming)
has related synonym: (3R)-3-hydroxybutanoyl-CoA hydro-lyase activity
has related synonym: crotonase activity
has related synonym: D-3-hydroxybutyryl-CoA dehydratase activity
has related synonym: D-3-hydroxybutyryl coenzyme A dehydratase activity
has related synonym: enoyl coenzyme A hydrase (D)

3-hydroxyisobutyryl-CoA hydrolase activity
type: Class
subclass of: GO_0016289
IAO_0000115: Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate.
has related synonym: 3-hydroxy-2-methylpropanoyl-CoA hydrolase activity
has related synonym: 3-hydroxy-isobutyryl CoA hydrolase activity
has related synonym: HIB CoA deacylase activity

3-isopropylmalate dehydratase activity
type: Class
subclass of: GO_0016836
IAO_0000115: Catalysis of the reaction: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate.
has related synonym: (2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)
has related synonym: (2R,3S)-3-isopropylmalate hydro-lyase activity
has related synonym: alpha-IPM isomerase activity
has related synonym: alpha-isopropylmalate isomerase activity
has related synonym: beta-isopropylmalate dehydratase activity
has related synonym: isopropylmalate isomerase activity

3-isopropylmalate dehydrogenase activity
type: Class
subclass of: GO_0016616
IAO_0000115: Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+.
has related synonym: (2R,3S)-3-isopropylmalate:NAD+ oxidoreductase activity
has related synonym: 3-carboxy-2-hydroxy-4-methylpentanoate:NAD+ oxidoreductase activity
has related synonym: beta-IPM dehydrogenase activity
has related synonym: beta-isopropylmalate dehydrogenase activity
has related synonym: beta-isopropylmalic enzyme
has related synonym: IMDH activity
has related synonym: IPMDH
has related synonym: threo-Ds-3-isopropylmalate dehydrogenase activity

3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
type: Class
subclass of: GO_0016624
IAO_0000115: Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2.
has related synonym: 2-oxoisocaproate dehydrogenase activity
has related synonym: 2-oxoisovalerate (lipoate) dehydrogenase activity
has related synonym: 3-methyl-2-oxobutanoate:dihydrolipoyllysine-residue (2-methylpropanoyl)transferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)
has related synonym: 3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating) activity
has related synonym: 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) activity
has related synonym: alpha-ketoacid dehydrogenase activity
has related synonym: alpha-keto-alpha-methylvalerate dehydrogenase activity
has related synonym: alpha-ketoisocaproate dehydrogenase activity
has related synonym: alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase activity
has related synonym: alpha-ketoisocaproic dehydrogenase activity
has related synonym: alpha-ketoisovalerate dehydrogenase activity
has related synonym: alpha-oxoisocaproate dehydrogenase activity
has related synonym: BCKDH activity
has related synonym: BCOAD activity
has related synonym: branched-chain (-2-oxoacid) dehydrogenase (BCD) activity
has related synonym: branched-chain 2-keto acid dehydrogenase activity
has related synonym: branched-chain 2-oxo acid dehydrogenase activity
has related synonym: branched-chain alpha-keto acid dehydrogenase activity
has related synonym: branched-chain alpha-oxo acid dehydrogenase activity
has related synonym: branched chain keto acid dehydrogenase activity
has related synonym: branched-chain ketoacid dehydrogenase activity
has related synonym: branched-chain keto acid dehydrogenase activity
has related synonym: dehydrogenase, 2-oxoisovalerate (lipoate) activity
has related synonym: dehydrogenase, branched chain alpha-keto acid activity
replaces: GO_0003826

3-methyl-2-oxobutanoate hydroxymethyltransferase activity
type: Class
subclass of: GO_0016742
IAO_0000115: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate.
has related synonym: 5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase activity
has related synonym: 5,10-methylene tetrahydrofolate:alpha-ketoisovalerate hydroxymethyltransferase activity
has related synonym: alpha-ketoisovalerate hydroxymethyltransferase activity
has related synonym: dehydropantoate hydroxymethyltransferase activity
has related synonym: ketopantoate hydroxymethyltransferase activity
has related synonym: oxopantoate hydroxymethyltransferase activity

3-oxo-5-alpha-steroid 4-dehydrogenase activity
type: Class
subclass of: GO_0033765
IAO_0000115: Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor.
has related synonym: 3-keto-delta4-steroid-5alpha-reductase activity
has related synonym: 3-oxo-5alpha-steroid:(acceptor) delta4-oxidoreductase activity
has related synonym: 3-oxo-5alpha-steroid:acceptor delta4-oxidoreductase activity
has related synonym: 3-oxo-5alpha-steroid 4-dehydrogenase activity
has related synonym: 3-oxo-5alpha-steroid delta4-dehydrogenase activity
has related synonym: 3-oxosteroid delta4-dehydrogenase
has related synonym: 4-ene-3-ketosteroid-5alpha-oxidoreductase activity
has related synonym: 5alpha-reductase
has related synonym: delta4-3-ketosteroid5alpha-oxidoreductase activity
has related synonym: delta4-3-keto steroid 5alpha-reductase activity
has related synonym: delta4-3-oxosteroid-5alpha-reductase
has related synonym: delta4-3-oxo steroid reductase activity
has related synonym: delta4-5alpha-dehydrogenase activity
has related synonym: steroid 5alpha-reductase
has related synonym: steroid 5 alpha reductase
has related synonym: steroid 5-alpha-reductase activity
has related synonym: steroid delta4-5alpha-reductase activity
has related synonym: testosterone 5alpha-reductase

3-phosphoshikimate 1-carboxyvinyltransferase activity
type: Class
subclass of: GO_0016765
IAO_0000115: Catalysis of the reaction: 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate.
has related synonym: 3-enol-pyruvoylshikimate-5-phosphate synthase activity
has related synonym: 5-enolpyruvylshikimate-3-phosphate synthase activity
has related synonym: EPSP synthase activity
has related synonym: phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase activity

4-aminobutyrate transaminase activity
type: Class
subclass of: GO_0008483
IAO_0000115: Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid.
has exact synonym: 4-aminobutanoate transaminase activity
has exact synonym: 4-aminobutyrate aminotransferase activity
has exact synonym: 4-aminobutyric acid aminotransferase activity
has exact synonym: aminobutyrate aminotransferase activity
has exact synonym: aminobutyrate transaminase activity
has related synonym: beta-alanine aminotransferase
has exact synonym: GABA aminotransferase activity
has exact synonym: GABA transaminase activity
has exact synonym: GABA transferase activity
has exact synonym: gamma-aminobutyrate aminotransaminase activity
has exact synonym: gamma-aminobutyrate transaminase activity
has exact synonym: gamma-aminobutyric acid aminotransferase activity
has exact synonym: gamma-aminobutyric acid transaminase activity
has exact synonym: gamma-aminobutyric transaminase activity
has exact synonym: gamma-amino-N-butyrate transaminase activity
has exact synonym: glutamate-succinic semialdehyde transaminase activity

4-hydroxyphenylpyruvate dioxygenase activity
type: Class
subclass of: GO_0016702
IAO_0000115: Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.
has related synonym: 4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating)
has related synonym: 4-hydroxyphenylpyruvate hydroxylase activity
has related synonym: 4-hydroxyphenylpyruvic acid dioxygenase activity
has related synonym: p-hydroxyphenylpyruvate dioxygenase activity
has related synonym: p-hydroxyphenylpyruvate hydroxylase activity
has related synonym: p-hydroxyphenylpyruvate oxidase activity
has related synonym: p-hydroxyphenylpyruvic acid hydroxylase activity
has related synonym: p-hydroxyphenylpyruvic hydroxylase activity
has related synonym: p-hydroxyphenylpyruvic oxidase activity

5-aminolevulinate synthase activity
type: Class
subclass of: GO_0016749
IAO_0000115: Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA.
has related synonym: 5-aminolevulinate synthetase activity
has related synonym: 5-aminolevulinic acid synthase activity
has related synonym: 5-aminolevulinic acid synthetase activity
has related synonym: ALAS activity
has related synonym: ALA synthase activity
has related synonym: ALA synthetase activity
has related synonym: alpha-aminolevulinic acid synthase activity
has related synonym: aminolevulinate synthase activity
has related synonym: aminolevulinate synthetase activity
has related synonym: aminolevulinic acid synthase activity
has related synonym: aminolevulinic acid synthetase activity
has related synonym: aminolevulinic synthetase activity
has related synonym: delta-ALA synthetase activity
has related synonym: delta-aminolevulinate synthase activity
has related synonym: delta-aminolevulinate synthetase activity
has related synonym: delta-aminolevulinic acid synthase activity
has related synonym: delta-aminolevulinic acid synthetase activity
has related synonym: delta-aminolevulinic synthetase activity
has related synonym: succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
type: Class
subclass of: GO_0008172
subclass of: GO_0042085
IAO_0000115: Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate.
has related synonym: 5-methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase activity
has related synonym: cobalamin-independent methionine synthase activity
has related synonym: homocysteine methylase activity
has related synonym: MetE
has related synonym: methionine synthase (cobalamin-independent) activity
has related synonym: methyltetrahydropteroylpolyglutamate:homocysteine methyltransferase activity
has related synonym: methyltransferase, tetrahydropteroylglutamate-homocysteine transmethylase activity
has related synonym: tetrahydropteroylglutamate-homocysteine transmethylase activity
has related synonym: tetrahydropteroyltriglutamate methyltransferase activity

6-phosphofructokinase activity
type: Class
subclass of: GO_0008443
subclass of: part-of-parent-61615
IAO_0000115: Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate.
has exact synonym: 6-phosphofructokinase reduction
has related synonym: 6-phosphofructose 1-kinase activity
has related synonym: ATP:D-fructose-6-phosphate 1-phosphotransferase activity
has related synonym: ATP-dependent phosphofructokinase activity
has related synonym: D-fructose-6-phosphate 1-phosphotransferase activity
has related synonym: fructose 6-phosphate kinase activity
has related synonym: fructose 6-phosphokinase activity
has related synonym: nucleotide triphosphate-dependent phosphofructokinase activity
has related synonym: PFK
has related synonym: phospho-1,6-fructokinase activity
has related synonym: phosphofructokinase (phosphorylating)
has related synonym: phosphofructokinase I activity
has related synonym: phosphohexokinase activity

6-phosphofructo-2-kinase activity
type: Class
subclass of: GO_0008443
IAO_0000115: Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+).
has related synonym: 6-phosphofructo-2-kinase (phosphorylating)
has related synonym: 6-phosphofructose 2-kinase activity
has related synonym: ATP:beta-D-fructose-6-phosphate 2-phosphotransferase activity
has related synonym: ATP:D-fructose-6-phosphate 2-phosphotransferase activity
has related synonym: fructose 6-phosphate 2-kinase activity
has related synonym: phosphofructokinase 2 activity

6-pyruvoyltetrahydropterin synthase activity
type: Class
subclass of: GO_0016838
IAO_0000115: Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate.
has related synonym: 2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming)
has related synonym: 2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase activity
has related synonym: 6-pyruvoyl tetrahydrobiopterin synthase activity
has related synonym: PTPS activity

ADP-ribosylarginine hydrolase activity
type: Class
subclass of: GO_0016799
IAO_0000115: Catalysis of the reaction: N2-(ADP-D-ribosyl)-L-arginine + H2O = L-arginine + ADP-ribose.
has related synonym: ADP-ribose-L-arginine cleavage enzyme activity
has related synonym: ADP-ribose-L-arginine cleaving enzyme activity
has exact synonym: ADPribosylarginine hydrolase activity
has related synonym: N(omega)-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity
has related synonym: nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity
has related synonym: omega-protein-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity
has related synonym: protein ADP-ribosylarginine hydrolase activity
has related synonym: protein-nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity

AMP deaminase activity
type: Class
subclass of: GO_0047623
IAO_0000115: Catalysis of the reaction: AMP + H2O = IMP + NH3.
has related synonym: 5-adenylate deaminase activity
has related synonym: 5-adenylic acid deaminase activity
has related synonym: 5-AMP deaminase activity
has related synonym: adenosine 5-monophosphate deaminase activity
has related synonym: adenosine 5-phosphate aminohydrolase activity
has related synonym: adenosine monophosphate deaminase activity
has related synonym: adenylate aminohydrolase activity
has related synonym: adenylate deaminase activity
has exact synonym: adenylate deaminase reaction
has related synonym: adenylate desaminase activity
has related synonym: adenyl deaminase activity
has related synonym: adenylic acid deaminase activity
has related synonym: adenylic deaminase activity
has related synonym: AMP aminase activity
has related synonym: AMP aminohydrolase activity
has related synonym: myoadenylate deaminase activity

ATP adenylyltransferase activity
type: Class
subclass of: GO_0070566
IAO_0000115: Catalysis of the reaction: ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate.
has related synonym: adenine triphosphate adenylyltransferase activity
has exact synonym: ADP:ATP adenylyltransferase activity
has related synonym: AP-4-A phosphorylase activity
has related synonym: bis(5'-nucleosyl)-tetraphosphate phosphorylase (NDP-forming) activity
has related synonym: diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase activity
has related synonym: diadenosine 5',5'''-P1,P4-tetraphosphate alphabeta-phosphorylase (ADP-forming)
has related synonym: diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase activity
has related synonym: diadenosinetetraphosphate alphabeta-phosphorylase activity
has related synonym: diadenosinetetraphosphate alpha-beta-phosphorylase activity
has related synonym: dinucleoside oligophosphate alphabeta-phosphorylase activity

ATP citrate synthase activity
type: Class
subclass of: GO_0046912
IAO_0000115: Catalysis of the reaction: acetyl-CoA + ADP + H(+) + oxaloacetate + phosphate = ATP + citrate + CoA.
has related synonym: acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)
has related synonym: acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity
has related synonym: acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]
has related synonym: adenosine triphosphate citrate lyase activity
has related synonym: ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity
has related synonym: ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)
has related synonym: ATP citrate (pro-S)-lyase activity
has exact synonym: ATP-citrate (pro-S)-lyase activity
has related synonym: ATP-citrate (pro-S-)-lyase activity
has related synonym: ATP-citric lyase activity
has related synonym: citrate-ATP lyase activity
has related synonym: citrate cleavage enzyme activity
has related synonym: citric cleavage enzyme activity
replaces: GO_0046913

ATP phosphoribosyltransferase activity
type: Class
subclass of: GO_0016763
IAO_0000115: Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.
has related synonym: 1-(5-phospho-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase activity
has related synonym: adenosine triphosphate phosphoribosyltransferase activity
has related synonym: phosphoribosyladenosine triphosphate:pyrophosphate phosphoribosyltransferase activity
has related synonym: phosphoribosyladenosine triphosphate pyrophosphorylase activity
has related synonym: phosphoribosyladenosine triphosphate synthetase activity
has related synonym: phosphoribosyl-ATP:pyrophosphate-phosphoribosyl phosphotransferase activity
has related synonym: phosphoribosyl ATP:pyrophosphate phosphoribosyltransferase activity
has related synonym: phosphoribosyl-ATP diphosphorylase activity
has related synonym: phosphoribosyl-ATP pyrophosphorylase activity
has related synonym: phosphoribosyl ATP synthetase activity

protein C-terminal carboxyl O-methyltransferase activity
type: Class
subclass of: GO_0051998
subclass of: part-of-parent-6481
IAO_0000115: Catalysis of the transfer of a methyl group to the oxygen atom of a carboxyl group at the C-terminal of a protein.
has exact synonym: C-terminal protein carboxyl methyltransferase activity

CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity
type: Class
subclass of: GO_0017169
IAO_0000115: Catalysis of the reaction: myo-inositol + CDP-diacylglycerol = 1-phosphatidyl-1D-myo-inositol + CMP + H(+).
has related synonym: CDP-DG:inositol transferase activity
has related synonym: CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase activity
has related synonym: CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase activity
has related synonym: CDPdiacylglycerol-inositol 3-phosphatidyltransferase activity
has related synonym: CDP-diacylglycerol--inositol phosphatidyltransferase activity
has related synonym: CDP-diglyceride:inositol transferase activity
has related synonym: CDP diglyceride-inositol phosphatidyltransferase activity
has related synonym: CDP-diglyceride-inositol transferase activity
has related synonym: cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol 3-phosphatidyltransferase activity
has related synonym: cytidine diphosphodiglyceride-inositol phosphatidyltransferase activity
has related synonym: cytidine diphosphoglyceride-inositol phosphatidyltransferase activity
has related synonym: cytidine diphosphoglyceride-inositol transferase activity
has exact synonym: phosphatidylinositol synthase activity

CDP-diacylglycerol-serine O-phosphatidyltransferase activity
type: Class
subclass of: GO_0017169
IAO_0000115: Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine.
has related synonym: CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity
has related synonym: CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity
has related synonym: CDPdiacylglycerol-serine O-phosphatidyltransferase activity
has related synonym: CDP-diglyceride:serine phosphatidyltransferase activity
has related synonym: CDP-diglyceride-L-serine phosphatidyltransferase activity
has related synonym: CDPdiglyceride-serine O-phosphatidyltransferase activity
has related synonym: CDP-diglycerine-serine O-phosphatidyltransferase activity
has related synonym: cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity
has related synonym: cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity
has related synonym: cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity
has related synonym: phosphatidylserine synthase activity
has related synonym: phosphatidylserine synthetase activity
has related synonym: PS synthase activity
has related synonym: serine exchange enzyme

CTP synthase activity
type: Class
subclass of: GO_0016879
IAO_0000115: Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate.
has related synonym: CTP synthetase activity
has related synonym: cytidine 5'-triphosphate synthetase activity
has related synonym: cytidine triphosphate synthetase activity
has related synonym: uridine triphosphate aminase activity
has related synonym: UTP:ammonia ligase (ADP-forming)
has related synonym: UTP--ammonia ligase activity

D-amino-acid oxidase activity
type: Class
subclass of: GO_0016641
IAO_0000115: Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide.
has related synonym: D-amino-acid:oxygen oxidoreductase (deaminating)
has related synonym: L-amino acid:O2 oxidoreductase activity
has related synonym: new yellow enzyme

D-arabinono-1,4-lactone oxidase activity
type: Class
subclass of: GO_0016899
IAO_0000115: Catalysis of the reaction: D-arabinono-1,4-lactone + O(2) = dehydro-D-arabinono-1,4-lactone + H(2)O(2) + H(+).
has related synonym: D-arabinono-1,4-lactone:oxygen oxidoreductase activity

DNA (cytosine-5-)-methyltransferase activity
type: Class
subclass of: GO_0008757
subclass of: GO_0009008
subclass of: part-of-parent-90116
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.
has related synonym: cytosine 5-methyltransferase activity
has related synonym: cytosine DNA methylase activity
has related synonym: cytosine DNA methyltransferase activity
has related synonym: cytosine-specific DNA methyltransferase activity
has related synonym: deoxyribonucleic (cytosine-5-)-methyltransferase activity
has related synonym: deoxyribonucleic acid (cytosine-5-)-methyltransferase activity
has related synonym: deoxyribonucleic methylase activity
has related synonym: DNA 5-cytosine methylase activity
has related synonym: DNA-cytosine 5-methylase activity
has related synonym: DNA cytosine C(5) methylase activity
has related synonym: DNA cytosine C5 methylase activity
has related synonym: DNA cytosine methylase activity
has related synonym: DNA-cytosine methyltransferase activity
has related synonym: methylphosphotriester-DNA methyltransferase activity
has related synonym: modification methylase activity
has related synonym: restriction-modification system activity
has related synonym: S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase activity
has related synonym: site-specific DNA-methyltransferase (cytosine-specific) activity
has related synonym: type II DNA methylase activity
replaces: GO_0008326

DNA-directed DNA polymerase activity
type: Class
subclass of: GO_0034061
IAO_0000115: Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
has related synonym: alpha DNA polymerase activity
has related synonym: beta DNA polymerase activity
has related synonym: delta DNA polymerase activity
has related synonym: deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity
has related synonym: deoxyribonucleic acid duplicase activity
has related synonym: deoxyribonucleic duplicase activity
has related synonym: deoxyribonucleic polymerase I
has related synonym: DNA-dependent DNA polymerase activity
has related synonym: DNA duplicase activity
has related synonym: DNA nucleotidyltransferase (DNA-directed) activity
has related synonym: DNA polymerase alpha
has related synonym: DNA polymerase beta
has related synonym: DNA polymerase gamma
has related synonym: DNA polymerase I
has related synonym: DNA polymerase II
has related synonym: DNA polymerase III
has related synonym: DNA polymerase V activity
has related synonym: DNA replicase activity
has related synonym: duplicase
has related synonym: epsilon DNA polymerase activity
has related synonym: eta DNA polymerase activity
has related synonym: gamma DNA-directed DNA polymerase activity
has related synonym: iota DNA polymerase activity
has related synonym: kappa DNA polymerase activity
has related synonym: Klenow fragment
has related synonym: lambda DNA polymerase activity
has related synonym: mu DNA polymerase activity
has related synonym: nu DNA polymerase activity
has related synonym: sequenase
has related synonym: sigma DNA polymerase activity
has related synonym: Taq DNA polymerase
has related synonym: Taq Pol I
has related synonym: Tca DNA polymerase
has related synonym: theta DNA polymerase activity
has related synonym: zeta DNA polymerase activity
replaces: GO_0003888
replaces: GO_0003889
replaces: GO_0003890
replaces: GO_0003891
replaces: GO_0003893
replaces: GO_0003894
replaces: GO_0003895
replaces: GO_0008723
replaces: GO_0015999
replaces: GO_0016000
replaces: GO_0016448
replaces: GO_0016449
replaces: GO_0016450
replaces: GO_0016451
replaces: GO_0016452
replaces: GO_0019984

obsolete proliferating cell nuclear antigen
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A nuclear protein that associates as a trimer and then interacts with delta DNA polymerase and epsilon DNA polymerase, acting as an auxiliary factor for DNA replication and DNA repair.
replaces: GO_0005661

DNA primase activity
type: Class
subclass of: DNA-directed 5'-3' RNA polymerase activity
subclass of: part-of-parent-6269
IAO_0000115: Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases.
replaces: GO_0003897
replaces: GO_0003898

DNA-directed 5'-3' RNA polymerase activity
type: Class
subclass of: GO_0034062
subclass of: part-of-parent-32774
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
has related synonym: C ribonucleic acid formation factors
has related synonym: C RNA formation factors
has related synonym: deoxyribonucleic acid-dependent ribonucleic acid polymerase activity
has related synonym: DNA-dependent ribonucleate nucleotidyltransferase activity
has related synonym: DNA-dependent RNA nucleotidyltransferase activity
has related synonym: DNA-dependent RNA polymerase activity
has related synonym: DNA-directed RNA polymerase activity
has related synonym: DNA-directed RNA polymerase I activity
has related synonym: DNA-directed RNA polymerase II activity
has related synonym: DNA-directed RNA polymerase III activity
has related synonym: nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) activity
has related synonym: RNA nucleotidyltransferase (DNA-directed) activity
has related synonym: RNA polymerase I activity
has related synonym: RNA polymerase II activity
has related synonym: RNA polymerase III activity
has related synonym: transcriptase
replaces: GO_0000129

obsolete DNA-directed RNA polymerase I activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

obsolete DNA-directed RNA polymerase II activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

obsolete DNA-directed RNA polymerase III activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

deoxyribodipyrimidine photo-lyase activity
type: Class
subclass of: DNA photolyase activity
IAO_0000115: Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light.
has exact synonym: CPD photolyase activity
has related synonym: deoxyribocyclobutadipyrimidine pyrimidine-lyase activity
has exact synonym: deoxyribodipyrimidine photolyase activity
has related synonym: deoxyribonucleate pyrimidine dimer lyase (photosensitive)
has related synonym: deoxyribonucleic cyclobutane dipyrimidine photolyase activity
has related synonym: deoxyribonucleic photolyase activity
has related synonym: dipyrimidine photolyase (photosensitive)
has related synonym: DNA cyclobutane dipyrimidine photolyase activity
has related synonym: DNA-photoreactivating enzyme
has related synonym: photolyase activity
has related synonym: photoreactivating enzyme activity
has related synonym: phr A photolyase activity
has related synonym: PhrB photolyase activity
has related synonym: PRE

alkylbase DNA N-glycosylase activity
type: Class
subclass of: GO_0019104
IAO_0000115: Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site.
has related synonym: 3-methyladenine DNA glycosylase II
has related synonym: AlkA
has related synonym: alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)
has exact synonym: alkylbase DNA glycosidase activity
has related synonym: deoxyribonucleate 3-methyladenine glycosidase II
has exact synonym: DNA-3-methyladenine glycosidase II activity
has related synonym: DNA-3-methyladenine glycosylase II
has related synonym: DNA glycosidase II activity
replaces: GO_0004036

DNA-(apurinic or apyrimidinic site) endonuclease activity
type: Class
subclass of: GO_0140097
IAO_0000115: Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER).
has exact synonym: abasic deoxyendoribonuclease activity
has exact synonym: AP deoxyendoribonuclease activity
has exact synonym: apurinic/apyrimidinic endodeoxyribonuclease activity
has exact synonym: apurinic deoxyendoribonuclease activity
has exact synonym: apyrimidinic deoxyendoribonuclease activity
has exact synonym: deoxyribonuclease (apurinic or apyrimidinic) activity
has related synonym: endonuclease VIII activity
has related synonym: UV endonuclease

methylated-DNA-[protein]-cysteine S-methyltransferase activity
type: Class
subclass of: GO_0008172
IAO_0000115: Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine.
has related synonym: 6-O-methylguanine-DNA methyltransferase activity
has exact synonym: DNA-6-O-methylguanine:[protein]-L-cysteine S-methyltransferase activity
has related synonym: DNA-6-O-methylguanine:protein-L-cysteine S-methyltransferase activity
has related synonym: methylated-DNA-protein-cysteine S-methyltransferase activity
has exact synonym: MGMT
has related synonym: O6-alkylguanine-DNA alkyltransferase
has related synonym: O-6-methylguanine-DNA-alkyltransferase activity

DNA ligase activity
type: Class
subclass of: GO_0016886
subclass of: GO_0140097
IAO_0000115: Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+.

DNA ligase (ATP) activity
type: Class
subclass of: DNA ligase activity
IAO_0000115: Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m).
has related synonym: deoxyribonucleate ligase
has related synonym: deoxyribonucleic acid joinase
has related synonym: deoxyribonucleic acid-joining enzyme
has related synonym: deoxyribonucleic acid ligase
has related synonym: deoxyribonucleic acid repair enzyme
has related synonym: deoxyribonucleic joinase
has related synonym: deoxyribonucleic-joining enzyme
has related synonym: deoxyribonucleic ligase
has related synonym: deoxyribonucleic repair enzyme
has related synonym: DNA joinase activity
has related synonym: DNA-joining enzyme
has related synonym: DNA repair enzyme activity
has related synonym: poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming)
has related synonym: polydeoxyribonucleotide synthase (ATP) activity
has related synonym: polynucleotide ligase
has related synonym: polynucleotide ligase (ATP) activity
has related synonym: sealase activity

DNA ligase (NAD+) activity
type: Class
subclass of: DNA ligase activity
IAO_0000115: Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m).
has related synonym: deoxyribonucleate ligase
has related synonym: deoxyribonucleic acid joinase
has related synonym: deoxyribonucleic acid ligase
has related synonym: deoxyribonucleic joinase
has related synonym: deoxyribonucleic-joining enzyme
has related synonym: deoxyribonucleic ligase
has related synonym: deoxyribonucleic repair enzyme
has related synonym: DNA joinase activity
has related synonym: DNA-joining enzyme
has related synonym: DNA ligase (NAD)
has related synonym: DNA repair enzyme activity
has related synonym: poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming)
has related synonym: Polydeoxyribonucleotide synthase (NAD(+)) activity
has related synonym: polydeoxyribonucleotide synthase (NAD)
has related synonym: polydeoxyribonucleotide synthase (NAD+) activity
has related synonym: polynucleotide ligase
has related synonym: polynucleotide ligase (NAD(+)) activity
has related synonym: polynucleotide ligase (NAD)
has related synonym: polynucleotide ligase (NAD+) activity
has related synonym: polynucleotide ligase (nicotinamide adenine dinucleotide)
has related synonym: polynucleotide synthetase (nicotinamide adenine dinucleotide)
has related synonym: polynucleotide synthetase activity

DNA nucleotidylexotransferase activity
type: Class
subclass of: GO_0016779
subclass of: GO_0140097
IAO_0000115: Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
has related synonym: addase activity
has related synonym: deoxynucleotidyl terminal transferase activity
has related synonym: deoxyribonucleic acid nucleotidyltransferase activity
has related synonym: deoxyribonucleic nucleotidyltransferase activity
has related synonym: nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity
has related synonym: TdT
has related synonym: terminal addition enzyme activity
has related synonym: terminal deoxynucleotide transferase activity
has related synonym: terminal deoxynucleotidyltransferase activity
has related synonym: terminal deoxyribonucleotidyltransferase activity
has related synonym: terminal transferase activity

DNA photolyase activity
type: Class
subclass of: GO_0016830
subclass of: GO_0140097
IAO_0000115: Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA.

DNA (6-4) photolyase activity
type: Class
subclass of: DNA photolyase activity
IAO_0000115: Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA.

DNA topoisomerase activity
type: Class
subclass of: GO_0016853
subclass of: GO_0140097
IAO_0000115: Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA.
replaces: GO_0009387

DNA topoisomerase type I (single strand cut, ATP-independent) activity
type: Class
subclass of: DNA topoisomerase activity
IAO_0000115: Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
has related synonym: deoxyribonucleate topoisomerase
has related synonym: DNA topoisomerase I activity
has related synonym: nicking-closing enzyme activity
has related synonym: omega-protein activity
has related synonym: relaxing enzyme activity
has related synonym: swivelase activity
has related synonym: topoisomerase
has exact synonym: type I DNA topoisomerase activity
has exact synonym: type I topoisomerase activity
has related synonym: untwisting enzyme activity

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
type: Class
subclass of: DNA topoisomerase activity
subclass of: GO_0008094
IAO_0000115: Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.
has related synonym: deoxyribonucleate topoisomerase
has related synonym: deoxyribonucleic topoisomerase activity
has related synonym: DNA topoisomerase (ATP-hydrolysing)
has related synonym: DNA topoisomerase II
has related synonym: DNA topoisomerase II activity
has related synonym: DNA topoisomerase IV activity
has exact synonym: DNA topoisomerase type II activity
has related synonym: topoisomerase
has related synonym: topoisomerase II
has related synonym: type II DNA topoisomerase activity
replaces: GO_0061505

FMN adenylyltransferase activity
type: Class
subclass of: GO_0070566
IAO_0000115: Catalysis of the reaction: ATP + FMN = diphosphate + FAD.
has related synonym: adenosine triphosphate-riboflavine mononucleotide transadenylase activity
has related synonym: adenosine triphosphate-riboflavin mononucleotide transadenylase activity
has exact synonym: ATP:FMN adenylyltransferase activity
has related synonym: FAD diphosphorylase activity
has related synonym: FAD pyrophosphorylase activity
has related synonym: FAD synthetase activity
has related synonym: flavin adenine dinucleotide synthetase activity
has related synonym: riboflavin adenine dinucleotide pyrophosphorylase activity
has related synonym: riboflavine adenine dinucleotide adenylyltransferase activity
has related synonym: riboflavin mononucleotide adenylyltransferase activity

GMP reductase activity
type: Class
subclass of: GO_0046857
IAO_0000115: Catalysis of the reaction: IMP + NADP(+) + NH(4)(+) = GMP + 2 H(+) + NADPH.
has related synonym: guanosine 5'-monophosphate oxidoreductase activity
has related synonym: guanosine 5'-monophosphate reductase activity
has related synonym: guanosine 5'-phosphate reductase activity
has related synonym: guanosine monophosphate reductase activity
has related synonym: guanylate reductase activity
has related synonym: inosine-5'-phosphate:NADP+ oxidoreductase (aminating)
has related synonym: NADPH:GMP oxidoreductase (deaminating) activity
has related synonym: NADPH:guanosine-5'-phosphate oxidoreductase (deaminating) activity
has related synonym: NADPH2:guanosine-5'-phosphate oxidoreductase (deaminating)

GMP synthase activity
type: Class
subclass of: GO_0016879
subclass of: part-of-parent-3922
IAO_0000115: Catalysis of the reaction: ATP + XMP + NH4(+) = AMP + diphosphate + GMP + 2H(+).

GMP synthase (glutamine-hydrolyzing) activity
type: Class
subclass of: GO_0016884
subclass of: part-of-parent-6177
IAO_0000115: Catalysis of the reaction: ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate + 2H(+).
has related synonym: glutamine amidotransferase activity
has related synonym: GMP synthase (glutamine-hydrolysing)
has related synonym: GMP synthetase (glutamine-hydrolysing)
has related synonym: GMP synthetase (glutamine-hydrolyzing) activity
has related synonym: guanosine 5'-monophosphate synthetase activity
has related synonym: guanosine monophosphate synthetase (glutamine-hydrolyzing)
has related synonym: guanylate synthetase (glutamine-hydrolyzing)
has related synonym: xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)
has related synonym: xanthosine 5'-phosphate amidotransferase activity

GPI-anchor transamidase activity
type: Class
subclass of: cysteine-type endopeptidase activity
IAO_0000115: Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor.

GTPase activity
type: Class
subclass of: GO_0017111
IAO_0000115: Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
has related synonym: ARF small monomeric GTPase activity
has related synonym: dynamin GTPase activity
has related synonym: GTPase activity, coupled
has related synonym: heterotrimeric G-protein GTPase, alpha-subunit
has related synonym: heterotrimeric G-protein GTPase, beta-subunit
has related synonym: heterotrimeric G-protein GTPase, gamma-subunit
has related synonym: heterotrimeric G-protein GTPase activity
has related synonym: hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement
has related synonym: protein-synthesizing GTPase activity
has related synonym: protein-synthesizing GTPase activity, elongation
has related synonym: protein-synthesizing GTPase activity, initiation
has related synonym: protein-synthesizing GTPase activity, termination
has related synonym: Rab small monomeric GTPase activity
has related synonym: Ran small monomeric GTPase activity
has related synonym: Ras small monomeric GTPase activity
has related synonym: RHEB small monomeric GTPase activity
has related synonym: Rho small monomeric GTPase activity
has related synonym: Sar small monomeric GTPase activity
has related synonym: signal-recognition-particle GTPase activity
has related synonym: small monomeric GTPase activity
has related synonym: tubulin GTPase activity
replaces: GO_0061745

G protein activity
type: Class
subclass of: GTPase activity
subclass of: GO_0098772
IAO_0000115: A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP).
has related synonym: heterotrimeric G-protein GTPase activity
has related synonym: large G-protein activity
has related synonym: large G-protein GTPase activity
has related synonym: Ras superfamily protein
has exact synonym: signaling G protein activity
has related synonym: small G-protein
has related synonym: small GTPase
has related synonym: small GTPase activity
has related synonym: small monomeric G protein activity
has related synonym: small monomeric GTPase activity
replaces: GO_0003927

obsolete ARF small monomeric GTPase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate.

obsolete RAB small monomeric GTPase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate.

obsolete RAN small monomeric GTPase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate.

obsolete RAS small monomeric GTPase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate.

obsolete Rho small monomeric GTPase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Any member of the Rho subfamily of the RAS superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton.

obsolete SAR small monomeric GTPase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate.

GTP cyclohydrolase activity
type: Class
subclass of: GO_0019238
IAO_0000115: Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized.

GTP cyclohydrolase I activity
type: Class
subclass of: GTP cyclohydrolase activity
IAO_0000115: Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate.
has related synonym: dihydroneopterin triphosphate synthase activity
has related synonym: GTP 7,8-8,9-dihydrolase activity
has related synonym: GTP 8-formylhydrolase activity
has related synonym: guanosine triphosphate 8-deformylase activity
has related synonym: guanosine triphosphate cyclohydrolase activity

GTP cyclohydrolase II activity
type: Class
subclass of: GTP cyclohydrolase activity
IAO_0000115: Catalysis of the reaction: GTP + 3 H(2)O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 3 H(+).
has related synonym: GTP 7,8-8,9-dihydrolase (diphosphate-forming)
has related synonym: GTP-8-formylhydrolase activity
has related synonym: guanosine triphosphate cyclohydrolase II

obsolete hydrogen-transporting two-sector ATPase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out).
replaces: GO_0004006
replaces: GO_0008729

IMP cyclohydrolase activity
type: Class
subclass of: GO_0019238
IAO_0000115: Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide.
has related synonym: IMP 1,2-hydrolase (decyclizing)
has related synonym: IMP synthetase activity
has related synonym: inosinate cyclohydrolase activity
has related synonym: inosinicase activity

IMP dehydrogenase activity
type: Class
subclass of: GO_0016616
IAO_0000115: Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+.
has related synonym: IMP:NAD+ oxidoreductase activity
has related synonym: IMP oxidoreductase activity
has related synonym: inosinate dehydrogenase activity
has related synonym: inosine 5'-monophosphate dehydrogenase activity
has related synonym: inosine-5'-phosphate dehydrogenase activity
has related synonym: inosine monophosphate dehydrogenase activity
has related synonym: inosine monophosphate oxidoreductase activity
has related synonym: inosinic acid dehydrogenase activity

L-iditol 2-dehydrogenase activity
type: Class
subclass of: GO_0016616
IAO_0000115: Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+.
has related synonym: glucitol dehydrogenase activity
has related synonym: L-iditol:NAD+ 5-oxidoreductase activity
has related synonym: L-iditol:NAD oxidoreductase activity
has related synonym: L-iditol (sorbitol) dehydrogenase activity
has related synonym: NAD+-dependent sorbitol dehydrogenase activity
has related synonym: NAD-dependent sorbitol dehydrogenase activity
has related synonym: NAD-sorbitol dehydrogenase
has related synonym: polyol dehydrogenase activity
has related synonym: sorbitol dehydrogenase activity

L-iduronidase activity
type: Class
subclass of: hydrolase activity, hydrolyzing O-glycosyl compounds
IAO_0000115: Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in dermatan sulfate.
has related synonym: alpha-L-iduronidase activity
has related synonym: glycosaminoglycan alpha-L-iduronohydrolase activity

L-serine ammonia-lyase activity
type: Class
subclass of: GO_0016841
IAO_0000115: Catalysis of the reaction: L-serine = pyruvate + NH3.
has related synonym: L-hydroxyaminoacid dehydratase activity
has related synonym: L-serine ammonia-lyase (pyruvate-forming) activity
has exact synonym: L-serine deaminase activity
has related synonym: L-serine dehydratase activity
has related synonym: L-serine dehydration activity
has exact synonym: L-serine hydro-lyase (deaminating) activity
has related synonym: serine deaminase activity

N-acetyl-gamma-glutamyl-phosphate reductase activity
type: Class
subclass of: GO_0016620
IAO_0000115: Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+.
has related synonym: N-acetylglutamate 5-semialdehyde dehydrogenase activity
has related synonym: N-acetyl-glutamate semialdehyde dehydrogenase activity
has related synonym: N-acetylglutamic gamma-semialdehyde dehydrogenase activity
has related synonym: N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)
has related synonym: N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating)
has related synonym: NAGSA dehydrogenase activity
has related synonym: reductase, acetyl-gamma-glutamyl phosphate

N-acetylgalactosamine-4-sulfatase activity
type: Class
subclass of: GO_0008484
IAO_0000115: Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate.
has related synonym: acetylgalactosamine 4-sulfatase activity
has exact synonym: arylsulfatase B
has related synonym: chondroitinsulfatase
has related synonym: N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity
has related synonym: N-acetylgalactosamine 4-sulfate sulfohydrolase activity
has exact synonym: N-acetylgalactosamine-4-sulphatase activity

N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity
type: Class
subclass of: GO_0015929
IAO_0000115: Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose.
has related synonym: 2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester acetamidodeoxyglucohydrolase activity
has related synonym: alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase activity
has related synonym: alpha-N-acetylglucosaminyl phosphodiesterase activity
has related synonym: glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase activity
has related synonym: lysosomal alpha-N-acetylglucosaminidase activity
has related synonym: phosphodiester glycosidase activity

N-acetyllactosamine synthase activity
type: Class
subclass of: GO_0035250
IAO_0000115: Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine.
has related synonym: acetyllactosamine synthetase activity
has related synonym: beta-(1,4)-galactosyltransferase activity
has related synonym: beta-1,4-galactosyltransferase activity
has related synonym: beta-1,4-GalT
has related synonym: beta-N-acetylglucosaminide beta-1,4-galactosyltransferase activity
has related synonym: Gal-T
has related synonym: lactosamine synthase activity
has related synonym: lactosamine synthetase activity
has related synonym: lactose synthetase A protein
has related synonym: N-acetylglucosamine (beta-1,4)galactosyltransferase activity
has related synonym: N-acetylglucosamine beta-(1,4)-galactosyltransferase activity
has related synonym: N-acetyllactosamine synthetase activity
has related synonym: NAL synthetase activity
has related synonym: UDP-beta-1,4-galactosyltransferase activity
has related synonym: UDP-Gal:N-acetylglucosamine beta-1,4-galactosyltransferase activity
has related synonym: UDPgalactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity
has exact synonym: UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity
has related synonym: UDP-galactose:N-acetylglucosaminide beta-1,4-galactosyltransferase activity
has related synonym: UDPgalactose:N-acetylglucosaminyl(beta-1,4)galactosyltransferase activity
has related synonym: UDP-galactose-acetylglucosamine galactosyltransferase activity
has related synonym: UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase activity
has related synonym: UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase activity
has related synonym: UDPgalactose-N-acetylglucosamine beta-D-galactosyltransferase activity
has related synonym: UDP-galactose-N-acetylglucosamine beta-D-galactosyltransferase activity
has related synonym: UDP-galactose-N-acetylglucosamine galactosyltransferase activity
has related synonym: uridine diphosphogalactose-acetylglucosamine galactosyltransferase activity

(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity
type: Class
subclass of: GO_0008376
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide.
has related synonym: asialo-GM2 synthase activity
has related synonym: beta-1,4N-aetylgalactosaminyltransferase activity
has related synonym: GalNAc-T activity
has related synonym: ganglioside GM2 synthase activity
has related synonym: ganglioside GM3 acetylgalactosaminyltransferase activity
has related synonym: GM2/GD2-synthase activity
has related synonym: GM2 synthase activity
has related synonym: UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide acetylgalactosaminyltransferase activity
has related synonym: UDP-N-acetyl-D-galactosamine:(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetyl-D-galactosaminyltransferase activity
has related synonym: UDP-N-acetyl-D-galactosamine:1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide 1,4-beta-N-acetyl-D-galactosaminyltransferase activity
has related synonym: UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase activity
has related synonym: uridine diphosphoacetylgalactosamine-acetylneuraminylgalactosylglucosylceramide acetylgalactosaminyltransferase activity
has related synonym: uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase activity
has related synonym: uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase activity

N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity
type: Class
subclass of: GO_0016811
IAO_0000115: Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+).
has related synonym: 4-N-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity
has related synonym: aspartylglucosaminidase activity
has related synonym: aspartylglucosylaminase activity
has related synonym: aspartylglucosylamine deaspartylase activity
has related synonym: aspartylglucosylaminidase activity
has related synonym: aspartylglycosylamine amidohydrolase activity
has related synonym: beta-aspartylglucosylamine amidohydrolase activity
has related synonym: glucosylamidase activity
has related synonym: glycosylasparaginase activity
has related synonym: N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity
has related synonym: N-aspartyl-beta-glucosaminidase activity

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity
type: Class
subclass of: GO_0016861
IAO_0000115: Catalysis of the reaction: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
has related synonym: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide aldose-ketose-isomerase activity
has related synonym: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide ketol-isomerase activity
has related synonym: N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide isomerase activity
has related synonym: N-(phosphoribosylformimino) aminophosphoribosylimidazolecarboxamide isomerase activity
has related synonym: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase activity
has related synonym: phosphoribosylformiminoaminophosphoribosylimidazolecarboxamide isomerase activity

NAD+ ADP-ribosyltransferase activity
type: Class
subclass of: GO_0016763
IAO_0000115: Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
has related synonym: ADP-ribosyltransferase (polymerizing) activity
has related synonym: NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity
has exact synonym: NAD ADP-ribosyltransferase activity
has related synonym: poly(adenosine diphosphate ribose) polymerase activity
has related synonym: poly(ADP-ribose)polymerase activity
has related synonym: poly(ADP-ribose) synthase activity
has related synonym: poly(ADP-ribose) synthetase activity

NAD+ kinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016773
IAO_0000115: Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+).
has related synonym: ATP:NAD+ 2'-phosphotransferase activity
has related synonym: DPN kinase activity
has related synonym: NADK
has exact synonym: NAD kinase activity
has related synonym: nicotinamide adenine dinucleotide kinase (phosphorylating)
has related synonym: nicotinamide adenine dinucleotide kinase activity

NAD+ synthase (glutamine-hydrolyzing) activity
type: Class
subclass of: GO_0016884
IAO_0000115: Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate.
has related synonym: deamido-NAD+:L-glutamine amido-ligase (AMP-forming)
has related synonym: desamidonicotinamide adenine dinucleotide amidotransferase activity
has related synonym: DPN synthetase activity
has related synonym: NAD(+) synthetase (glutamine-hydrolyzing) activity
has related synonym: NAD+ synthase (glutamine-hydrolysing)
has related synonym: NAD+ synthetase (glutamine-hydrolyzing)
has exact synonym: NAD synthase (glutamine-hydrolyzing) activity
has related synonym: NAD synthetase (glutamine-hydrolysing)
has related synonym: nicotinamide adenine dinucleotide synthetase (glutamine) activity

NAD+ nucleosidase activity
type: Class
subclass of: GO_0016799
IAO_0000115: Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose.
has exact synonym: NAD nucleosidase activity

NADH dehydrogenase activity
type: Class
subclass of: GO_0016651
IAO_0000115: Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.
has related synonym: beta-NADH dehydrogenase dinucleotide activity
has related synonym: cytochrome c reductase activity
has related synonym: diaphorase activity
has related synonym: dihydrocodehydrogenase I dehydrogenase activity
has related synonym: dihydronicotinamide adenine dinucleotide dehydrogenase activity
has related synonym: diphosphopyridine diaphorase activity
has related synonym: diphosphopyrinase activity
has related synonym: DPNH diaphorase activity
has related synonym: NADH:(acceptor) oxidoreductase activity
has related synonym: NADH:acceptor oxidoreductase activity
has related synonym: NADH:cytochrome c oxidoreductase activity
has related synonym: NADH2 dehydrogenase activity
has related synonym: NADH diaphorase activity
has related synonym: NADH hydrogenase activity
has related synonym: NADH-menadione oxidoreductase activity
has related synonym: NADH oxidoreductase activity
has related synonym: reduced diphosphopyridine nucleotide diaphorase activity
has related synonym: type 1 dehydrogenase activity
has related synonym: type I dehydrogenase activity

NAD(P)H dehydrogenase (quinone) activity
type: Class
subclass of: GO_0016655
IAO_0000115: Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a hydroquinone.
has related synonym: azoreductase activity
has related synonym: dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone) activity
has related synonym: diaphorase activity
has related synonym: DT-diaphorase activity
has related synonym: flavoprotein NAD(P)H-quinone reductase activity
has related synonym: menadione oxidoreductase activity
has related synonym: menadione reductase activity
has related synonym: NAD(P)H:(quinone-acceptor)oxidoreductase activity
has related synonym: NAD(P)H: menadione oxidoreductase activity
has related synonym: NAD(P)H:quinone oxidoreductase activity
has related synonym: NAD(P)H(2) dehydrogenase (quinone) activity
has related synonym: NAD(P)H2 dehydrogenase (quinone)
has related synonym: NAD(P)H dehydrogenase activity
has related synonym: NAD(P)H menadione reductase activity
has related synonym: NAD(P)H-quinone dehydrogenase activity
has related synonym: NAD(P)H-quinone oxidoreductase activity
has related synonym: NADH-menadione reductase activity
has related synonym: naphthoquinone reductase activity
has related synonym: NQO1
has related synonym: p-benzoquinone reductase activity
has related synonym: phylloquinone reductase activity
has related synonym: QR1
has related synonym: quinone reductase activity
has related synonym: reduced NAD(P)H dehydrogenase activity
has related synonym: reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase activity
has related synonym: viologen accepting pyridine nucleotide oxidoreductase activity
has related synonym: vitamin K reductase activity
has related synonym: vitamin-K reductase activity

NAD(P)+ transhydrogenase (B-specific) activity
type: Class
subclass of: GO_0008746
subclass of: GO_0015078
IAO_0000115: Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+, driving the transfer of a solute or solutes from one side of a membrane to the other. In the course of the reaction (left to right) one H atom is transferred from inside the cell to outside. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+.
has related synonym: H+-thase
has exact synonym: NAD(P) transhydrogenase (B-specific) activity
has related synonym: NADH-NADP-transhydrogenase
has related synonym: NADH transhydrogenase
has related synonym: NADPH:NAD+ oxidoreductase (B-specific)
has related synonym: NADPH:NAD+ transhydrogenase
has related synonym: NADPH-NAD oxidoreductase
has related synonym: NADPH-NAD transhydrogenase
has related synonym: NAD transhydrogenase
has related synonym: nicotinamide adenine dinucleotide (phosphate) transhydrogenase
has related synonym: nicotinamide nucleotide transhydrogenase activity
has related synonym: non-energy-linked transhydrogenase activity
has related synonym: pyridine nucleotide transferase
has related synonym: pyridine nucleotide transhydrogenase activity

NADPH-hemoprotein reductase activity
type: Class
subclass of: GO_0016653
IAO_0000115: Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.
has related synonym: aldehyde reductase (NADPH-dependent) activity
has related synonym: CPR activity
has related synonym: cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent) activity
has related synonym: cytochrome P450 reductase activity
has related synonym: cytochrome P-450 reductase activity
has related synonym: dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity
has related synonym: FAD-cytochrome c reductase activity
has related synonym: ferrihemoprotein P-450 reductase activity
has related synonym: NADP--cytochrome c reductase activity
has related synonym: NADP--cytochrome reductase activity
has exact synonym: NADPH:cytochrome c reductase activity
has exact synonym: NADPH:cytochrome P450 reductase activity
has related synonym: NADPH:ferrihemoprotein oxidoreductase activity
has related synonym: NADPH:hemoprotein oxidoreductase activity
has related synonym: NADPH:P450 reductase activity
has related synonym: NADPH:P-450 reductase activity
has related synonym: NADPH--cytochrome c oxidoreductase activity
has related synonym: NADPH--cytochrome c reductase activity
has related synonym: NADPH-cytochrome P-450 oxidoreductase activity
has related synonym: NADPH--cytochrome P450 oxidoreductase activity
has related synonym: NADPH-cytochrome p-450 reductase activity
has related synonym: NADPH--cytochrome P450 reductase activity
has related synonym: NADPH-dependent cytochrome c reductase activity
has related synonym: NADPH--ferricytochrome c oxidoreductase activity
has exact synonym: NADPH-ferrihemoprotein reductase activity
has related synonym: NADPH--ferrihemoprotein reductase activity
has related synonym: POR
has related synonym: reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity
has related synonym: reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate) activity
has related synonym: TPNH(2) cytochrome c reductase activity
has related synonym: TPNH2 cytochrome c reductase activity
has related synonym: TPNH-cytochrome c reductase activity

NADPH dehydrogenase activity
type: Class
subclass of: GO_0016651
IAO_0000115: Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor.
has related synonym: dihydronicotinamide adenine dinucleotide phosphate dehydrogenase activity
has related synonym: NADPH:(acceptor) oxidoreductase activity
has related synonym: NADPH:acceptor oxidoreductase activity
has related synonym: NADPH2-dehydrogenase activity
has related synonym: NADPH2 diaphorase activity
has related synonym: NADPH-dehydrogenase activity
has related synonym: NADPH diaphorase activity
has related synonym: old yellow enzyme
has related synonym: OYE
has related synonym: reduced nicotinamide adenine dinucleotide phosphate dehydrogenase activity
has related synonym: TPNH dehydrogenase activity
has related synonym: TPNH-diaphorase activity
has related synonym: triphosphopyridine diaphorase activity
has related synonym: triphosphopyridine nucleotide diaphorase activity
replaces: GO_0008468
replaces: GO_0016660

NADPH:quinone reductase activity
type: Class
subclass of: GO_0016655
IAO_0000115: Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone.
has related synonym: NADPH:quinone oxidoreductase activity
has related synonym: quinone oxidoreductase activity
has related synonym: zeta-crystallin activity

O-acetylhomoserine aminocarboxypropyltransferase activity
type: Class
subclass of: GO_0016765
subclass of: part-of-parent-71266
IAO_0000115: Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate. Also reacts with other thiols and H2S, producing homocysteine or thioethers.
has exact synonym: L-methionine anabolism, direct, from O-acetyl-L-homoserine
has exact synonym: L-methionine biosynthetic process, direct, from O-acetyl-L-homoserine
has exact synonym: L-methionine formation, direct, from O-acetyl-L-homoserine
has exact synonym: L-methionine synthesis, direct, from O-acetyl-L-homoserine
has exact synonym: methionine biosynthetic process, direct, from O-acetyl-L-homoserine
has exact synonym: O-acetylhomoserine (thiol)-lyase activity
has related synonym: O-acetylhomoserine sulfhydrolase activity
has related synonym: O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase activity
has related synonym: O-acetyl-L-homoserine acetate-lyase (adding methanethiol) activity
has related synonym: O-acetyl-L-homoserine sulfhydrolase activity
has related synonym: OAH sulfhydrylase activity
replaces: GO_0019282

cystathionine gamma-synthase activity
type: Class
subclass of: GO_0016765
IAO_0000115: Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate.
has exact synonym: CTT gamma synthase activity
has exact synonym: cystathionine gamma synthase activity
has exact synonym: cystathionine g-synthase activity
has related synonym: cystathionine synthase activity
has related synonym: cystathionine synthetase activity
has related synonym: homoserine O-transsuccinylase activity
has related synonym: homoserine transsuccinylase activity
has related synonym: O4-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase activity
has related synonym: O-succinylhomoserine (thiol)-lyase activity
has related synonym: O-succinylhomoserine synthase activity
has related synonym: O-succinylhomoserine synthetase activity
has exact synonym: O-succinyl-L-homoserine (thiol)-lyase activity
has related synonym: O-succinyl-L-homoserine succinate-lyase (adding cysteine) activity
has exact synonym: O-succinyl-L-homoserine succinate-lyase activity
replaces: GO_0000505

RNA-3'-phosphate cyclase activity
type: Class
subclass of: GO_0009975
subclass of: GO_0016886
subclass of: GO_0140098
IAO_0000115: Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate.
has related synonym: RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming)
has related synonym: RNA 3'-terminal phosphate cyclase activity
has related synonym: RNA cyclase activity

RNA-directed DNA polymerase activity
type: Class
subclass of: GO_0034061
subclass of: part-of-parent-6278
IAO_0000115: Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time.
has related synonym: deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) activity
has related synonym: DNA nucleotidyltransferase (RNA-directed) activity
has related synonym: reverse transcriptase activity
has related synonym: revertase activity
has related synonym: RNA-dependent deoxyribonucleate nucleotidyltransferase activity
has related synonym: RNA-dependent DNA polymerase activity
has related synonym: RNA-directed DNA polymerase, group II intron encoded
has related synonym: RNA-directed DNA polymerase, transposon encoded
has related synonym: RNA-instructed DNA polymerase activity
has related synonym: RNA revertase activity
has related synonym: RT

obsolete RNA-directed DNA polymerase, transposon encoded
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo.

obsolete RNA-directed DNA polymerase, group II intron encoded
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo.

RNA-directed 5'-3' RNA polymerase activity
type: Class
subclass of: GO_0034062
subclass of: part-of-parent-1172
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.
has related synonym: 3D polymerase activity
has related synonym: nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
has related synonym: PB1 proteins
has related synonym: PB2 proteins
has related synonym: phage f2 replicase
has related synonym: polymerase L
has related synonym: Q-beta replicase activity
has related synonym: RDRP
has related synonym: ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity
has related synonym: ribonucleic acid-dependent ribonucleic acid polymerase activity
has related synonym: ribonucleic acid replicase activity
has related synonym: ribonucleic replicase activity
has related synonym: ribonucleic synthetase activity
has related synonym: RNA-dependent ribonucleate nucleotidyltransferase activity
has related synonym: RNA-dependent RNA polymerase activity
has related synonym: RNA-dependent RNA replicase activity
has related synonym: RNA-directed RNA polymerase activity
has related synonym: RNA nucleotidyltransferase (RNA-directed) activity
has related synonym: RNA replicase activity
has related synonym: RNA synthetase activity
has related synonym: transcriptase

obsolete RNA editase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

RNA ligase (ATP) activity
type: Class
subclass of: GO_0008452
IAO_0000115: Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m).
has related synonym: poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming)
has related synonym: polyribonucleotide ligase activity
has related synonym: polyribonucleotide synthase (ATP) activity
has related synonym: ribonucleic ligase activity

(S)-2-hydroxy-acid oxidase activity
type: Class
subclass of: GO_0016899
IAO_0000115: Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + hydrogen peroxide.
has related synonym: glycolate oxidase activity
has related synonym: hydroxyacid oxidase A
has related synonym: hydroxy-acid oxidase A activity
has related synonym: hydroxy-acid oxidase B activity
has related synonym: L-2-hydroxy acid oxidase
has related synonym: L-alpha-hydroxy acid oxidase
has related synonym: long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity
has related synonym: medium-chain-(S)-2-hydroxy-acid oxidase activity
has related synonym: very-long-chain-(S)-2-hydroxy-acid oxidase activity
replaces: GO_0008891
replaces: GO_0052852
replaces: GO_0052853
replaces: GO_0052854

UDP-N-acetylglucosamine 4-epimerase activity
type: Class
subclass of: GO_0016857
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine.
has related synonym: UDP acetylglucosamine epimerase activity
has related synonym: UDP-GlcNAc 4-epimerase activity
has related synonym: UDP-N-acetyl-D-glucosamine 4-epimerase activity
has related synonym: uridine 5'-diphospho-N-acetylglucosamine-4-epimerase activity
has related synonym: uridine diphosphate N-acetylglucosamine-4-epimerase activity
has related synonym: uridine diphosphoacetylglucosamine epimerase activity

UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity
type: Class
subclass of: GO_0016780
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol.
has related synonym: chitobiosylpyrophosphoryldolichol synthase activity
has related synonym: dolichol phosphate N-acetylglucosamine-1-phosphotransferase activity
has related synonym: GlcNAc-1-P transferase activity
has related synonym: N-acetylglucosamine-1-phosphate transferase activity
has related synonym: UDP-acetylglucosamine-dolichol phosphate acetylglucosamine-1-phosphotransferase activity
has related synonym: UDP-acetylglucosamine-dolichol phosphate acetylglucosamine phosphotransferase activity
has related synonym: UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase activity
has related synonym: UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase activity
has related synonym: UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase activity
has related synonym: UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase activity
has exact synonym: UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase activity
has related synonym: uridine diphosphoacetylglucosamine-dolichyl phosphate acetylglucosamine-1-phosphotransferase activity

UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity
type: Class
subclass of: GO_0016780
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose.
has related synonym: lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase activity
has related synonym: N-acetylglucosaminylphosphotransferase activity
has related synonym: N-acetylglucosaminyl phosphotransferase activity
has related synonym: UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferase activity
has related synonym: UDP-N-acetyl-D-glucosamine:lysosomal-enzyme N-acetylglucosaminephosphotransferase activity
has related synonym: UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase activity
has related synonym: UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyl-1-phosphotransferase activity
has related synonym: UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase activity

UDP-N-acetylglucosamine diphosphorylase activity
type: Class
subclass of: GO_0070569
IAO_0000115: Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine.
has related synonym: acetylglucosamine 1-phosphate uridylyltransferase
has related synonym: GlmU uridylyltransferase activity
has related synonym: N-acetylglucosamine-1-phosphate uridyltransferase activity
has related synonym: UDP-acetylglucosamine pyrophosphorylase activity
has related synonym: UDP-GlcNAc pyrophosphorylase activity
has exact synonym: UDP-N-acetylglucosamine pyrophosphorylase activity
has related synonym: uridine diphosphate-N-acetylglucosamine pyrophosphorylase activity
has related synonym: uridine diphosphoacetylglucosamine phosphorylase activity
has related synonym: uridine diphosphoacetylglucosamine pyrophosphorylase activity
has related synonym: UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate uridylyltransferase activity
has related synonym: UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase activity

UDP-glucose 4-epimerase activity
type: Class
subclass of: GO_0016857
IAO_0000115: Catalysis of the reaction: UDP-glucose = UDP-galactose.
has related synonym: 4-epimerase activity
has related synonym: galactowaldenase activity
has related synonym: UDP-D-galactose 4-epimerase activity
has related synonym: UDPG-4-epimerase activity
has related synonym: UDPgalactose 4-epimerase activity
has related synonym: UDP-galactose 4-epimerase activity
has related synonym: UDPglucose 4-epimerase activity
has related synonym: UDP-glucose epimerase activity
has related synonym: uridine diphosphate galactose 4-epimerase activity
has related synonym: uridine diphosphate glucose 4-epimerase activity
has related synonym: uridine diphospho-galactose-4-epimerase activity
has related synonym: uridine diphosphoglucose 4-epimerase activity
has related synonym: uridine diphosphoglucose epimerase activity

UDP-glucose 6-dehydrogenase activity
type: Class
subclass of: GO_0016616
IAO_0000115: Catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate.

UDP-glucose:glycoprotein glucosyltransferase activity
type: Class
subclass of: GO_0035251
subclass of: part-of-parent-97359
IAO_0000115: Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins.
has exact synonym: UGGT activity

UTP:glucose-1-phosphate uridylyltransferase activity
type: Class
subclass of: GO_0051748
IAO_0000115: Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose.
has related synonym: glucose-1-phosphate uridylyltransferase activity
has related synonym: UDP-glucose diphosphorylase activity
has related synonym: UDP glucose pyrophosphorylase activity
has related synonym: UDP-glucose pyrophosphorylase activity
has related synonym: UDPG phosphorylase activity
has related synonym: UDPG pyrophosphorylase activity
has related synonym: uridine 5'-diphosphoglucose pyrophosphorylase activity
has related synonym: uridine diphosphate-D-glucose pyrophosphorylase activity
has related synonym: uridine-diphosphate glucose pyrophosphorylase activity
has related synonym: uridine diphosphoglucose pyrophosphorylase activity
has related synonym: UTP:alpha-D-glucose-1-phosphate uridylyltransferase activity
has related synonym: UTP-glucose-1-phosphate uridylyltransferase activity

acetolactate synthase activity
type: Class
subclass of: GO_0016744
IAO_0000115: Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2.
has related synonym: acetohydroxyacid synthase activity
has related synonym: acetohydroxy acid synthetase activity
has related synonym: acetolactate pyruvate-lyase (carboxylating) activity
has related synonym: acetolactic synthetase activity
has related synonym: alpha-acetohydroxyacid synthase activity
has related synonym: alpha-acetohydroxy acid synthetase activity
has related synonym: alpha-acetolactate synthase activity
has related synonym: alpha-acetolactate synthetase activity
has related synonym: pyruvate:pyruvate acetaldehydetransferase (decarboxylating)

acetyl-CoA C-acetyltransferase activity
type: Class
subclass of: acetyl-CoA C-acyltransferase activity
subclass of: GO_0016453
IAO_0000115: Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA.
has related synonym: 2-methylacetoacetyl-CoA thiolase
has related synonym: 3-oxothiolase activity
has related synonym: acetoacetyl-CoA thiolase activity
has related synonym: acetyl-CoA:acetyl-CoA C-acetyltransferase activity
has related synonym: acetyl-CoA:N-acetyltransferase activity
has related synonym: acetyl-CoA acetyltransferase activity
has related synonym: acetyl coenzyme A thiolase activity
has related synonym: beta-acetoacetyl coenzyme A thiolase activity
has related synonym: thiolase II

acetyl-CoA hydrolase activity
type: Class
subclass of: GO_0016289
IAO_0000115: Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+).
has related synonym: acetyl-CoA acylase activity
has related synonym: acetyl-CoA deacylase activity
has related synonym: acetyl-CoA thiol esterase activity
has related synonym: acetyl coenzyme A acylase activity
has related synonym: acetyl coenzyme A deacylase activity
has related synonym: acetyl coenzyme A hydrolase activity

acetate-CoA ligase activity
type: Class
subclass of: GO_0016405
subclass of: GO_0016878
IAO_0000115: Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
has related synonym: acetate:CoA ligase (AMP-forming)
has related synonym: acetate thiokinase activity
has related synonym: acetate to acetyl-CoA
has related synonym: acetic thiokinase activity
has related synonym: acetyl activating enzyme
has related synonym: acetyl-activating enzyme activity
has related synonym: acetyl CoA ligase activity
has related synonym: acetyl CoA synthase activity
has related synonym: acetyl-CoA synthase activity
has related synonym: acetyl-CoA synthetase activity
has related synonym: acetyl-coenzyme A synthase activity
has related synonym: acetyl coenzyme A synthetase activity
has related synonym: ACS
has related synonym: acyl-activating enzyme activity
has related synonym: short-chain acyl-coenzyme A synthetase activity
has related synonym: short chain fatty acyl-CoA synthetase activity

acetyl-CoA C-acyltransferase activity
type: Class
subclass of: GO_0016408
IAO_0000115: Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
has exact synonym: 2-keto-acyl thiolase activity
has related synonym: 2-methylacetoacetyl-CoA thiolase
has related synonym: 3-ketoacyl CoA thiolase activity
has exact synonym: 3-ketoacyl-CoA thiolase activity
has exact synonym: 3-ketoacyl coenzyme A thiolase activity
has exact synonym: 3-ketoacyl thiolase activity
has exact synonym: 3-ketothiolase activity
has exact synonym: 3-oxoacyl-CoA thiolase activity
has exact synonym: 3-oxoacyl-coenzyme A thiolase activity
has exact synonym: 6-oxoacyl-CoA thiolase activity
has exact synonym: acetoacetyl-CoA beta-ketothiolase activity
has exact synonym: acetyl-CoA acyltransferase activity
has related synonym: acyl-CoA:acetyl-CoA C-acyltransferase activity
has related synonym: beta-ketoacyl-CoA thiolase activity
has exact synonym: beta-ketoacyl coenzyme A thiolase activity
has related synonym: beta-ketoadipyl-CoA thiolase activity
has exact synonym: beta-ketoadipyl coenzyme A thiolase activity
has exact synonym: beta-ketothiolase activity
has related synonym: KAT
has exact synonym: ketoacyl-CoA acyltransferase activity
has exact synonym: ketoacyl-coenzyme A thiolase activity
has exact synonym: long-chain 3-oxoacyl-CoA thiolase activity
has exact synonym: oxoacyl-coenzyme A thiolase activity
has exact synonym: pro-3-ketoacyl-CoA thiolase activity
has related synonym: thiolase I

acetyl-CoA carboxylase activity
type: Class
subclass of: GO_0016421
IAO_0000115: Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.
has related synonym: acetyl-CoA:carbon-dioxide ligase (ADP-forming)
has related synonym: acetyl coenzyme A carboxylase activity

acetylcholinesterase activity
type: Class
subclass of: cholinesterase activity
IAO_0000115: Catalysis of the reaction: acetylcholine + H2O = choline + acetate.
has related synonym: AcCholE
has related synonym: acetyl.beta-methylcholinesterase activity
has related synonym: acetylcholine acetylhydrolase activity
has related synonym: acetylcholine hydrolase activity
has related synonym: acetylthiocholinesterase activity
has related synonym: choline esterase I activity
has related synonym: true cholinesterase activity

acetylglutamate kinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016774
IAO_0000115: Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate-5-phosphate.
has related synonym: acetylglutamate phosphokinase activity
has related synonym: ATP:N-acetyl-L-glutamate 5-phosphotransferase activity
has related synonym: N-acetylglutamate 5-phosphotransferase activity
has related synonym: N-acetylglutamate kinase activity
has related synonym: N-acetylglutamate phosphokinase activity
has related synonym: N-acetylglutamic 5-phosphotransferase activity

N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
type: Class
subclass of: GO_0008483
IAO_0000115: Catalysis of the reaction: 2-oxoglutarate + N(2)-acetyl-L-ornithine = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.
has related synonym: 2-N-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
has related synonym: acetylornithine 5-aminotransferase activity
has related synonym: acetylornithine aminotransferase activity
has related synonym: acetylornithine delta-transaminase activity
has related synonym: acetylornithine transaminase activity
has related synonym: ACOAT activity
has related synonym: N(2)-acetylornithine 5-transaminase activity
has related synonym: N2-acetyl-L-ornithine:2-oxoglutarate aminotransferase activity
has exact synonym: N2-acetylornithine 5-aminotransferase activity
has related synonym: N2-acetylornithine 5-transaminase activity
has related synonym: N-acetylornithine aminotransferase activity
has related synonym: N-acetylornithine-delta-transaminase activity
has related synonym: succinylornithine aminotransferase activity
replaces: GO_0047318

acid phosphatase activity
type: Class
subclass of: GO_0016791
IAO_0000115: Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum.
has related synonym: acid monophosphatase activity
has related synonym: acid nucleoside diphosphate phosphatase activity
has related synonym: acid phosphohydrolase activity
has related synonym: acid phosphomonoesterase activity
has related synonym: acid phosphomonoester hydrolase activity
has related synonym: glycerophosphatase activity
has related synonym: orthophosphoric-monoester phosphohydrolase (acid optimum)
has related synonym: phosphate-monoester phosphohydrolase (acid optimum)
has related synonym: phosphomonoesterase activity
has related synonym: uteroferrin

aconitate hydratase activity
type: Class
subclass of: GO_0016836
IAO_0000115: Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate.
has exact synonym: aconitase activity
has related synonym: cis-aconitase activity
has related synonym: citrate(isocitrate) hydro-lyase (cis-aconitate-forming)
has related synonym: citrate(isocitrate) hydro-lyase activity
has related synonym: citrate hydro-lyase activity

acyl-CoA dehydrogenase activity
type: Class
subclass of: GO_0052890
IAO_0000115: Catalysis of the reaction: acyl-CoA + oxidized [electron-transfer flavoprotein]= 2,3-dehydroacyl-CoA + reduced [electron-transfer flavoprotein] + H+.
has exact synonym: acyl CoA dehydrogenase activity
has exact synonym: acyl-CoA reductase activity
has exact synonym: acyl coenzyme A dehydrogenase activity
has related synonym: fatty-acyl-CoA dehydrogenase activity
has related synonym: fatty acyl coenzyme A dehydrogenase activity
has related synonym: general acyl CoA dehydrogenase activity
replaces: GO_0019109

acyl-CoA oxidase activity
type: Class
subclass of: GO_0016634
IAO_0000115: Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide.
has related synonym: acyl-CoA:oxygen 2-oxidoreductase activity
has related synonym: acyl coenzyme A oxidase activity
has related synonym: fatty acyl-CoA oxidase activity
has related synonym: fatty acyl-coenzyme A oxidase activity

acylphosphatase activity
type: Class
subclass of: GO_0016462
IAO_0000115: Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate.
has related synonym: 1,3-diphosphoglycerate phosphatase activity
has related synonym: acetic phosphatase activity
has related synonym: acetylphosphatase activity
has related synonym: acylphosphate phosphohydrolase activity
has related synonym: GP 1-3
has related synonym: Ho 1-3

adenine phosphoribosyltransferase activity
type: Class
subclass of: GO_0106130
IAO_0000115: Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.
has related synonym: adenine phosphoribosylpyrophosphate transferase activity
has related synonym: adenosine phosphoribosyltransferase activity
has related synonym: adenylate pyrophosphorylase activity
has related synonym: adenylic pyrophosphorylase activity
has related synonym: AMP:diphosphate phospho-D-ribosyltransferase activity
has related synonym: AMP diphosphorylase activity
has related synonym: AMP-pyrophosphate phosphoribosyltransferase activity
has related synonym: AMP pyrophosphorylase activity
has related synonym: APRT activity
has related synonym: transphosphoribosidase activity

adenosine deaminase activity
type: Class
subclass of: GO_0016814
subclass of: GO_0019239
IAO_0000115: Catalysis of the reaction: adenosine + H2O = inosine + NH3.
has related synonym: adenosine aminohydrolase activity
has exact synonym: adenosine deaminase reaction

adenosine kinase activity
type: Class
subclass of: GO_0016773
subclass of: GO_0019206
subclass of: part-of-parent-6167
IAO_0000115: Catalysis of the reaction: ATP + adenosine = ADP + AMP.
has exact synonym: adenosine 5-phosphotransferase activity
has related synonym: adenosine kinase (phosphorylating)
has related synonym: ATP:adenosine 5'-phosphotransferase activity

obsolete plasma membrane cation-transporting ATPase
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete heavy metal-exporting ATPase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: heavy metal ion(in) + ATP + H2O = heavy metal ion(out) + ADP + phosphate.

obsolete ATP-binding cassette (ABC) transporter activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

adenosylhomocysteinase activity
type: Class
subclass of: GO_0016802
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine.
has related synonym: adenosylhomocysteine hydrolase activity
has related synonym: AdoHcyase activity
has related synonym: S-adenosylhomocysteinase activity
has related synonym: S-adenosylhomocysteine hydrolase activity
has related synonym: S-adenosylhomocysteine synthase activity
has related synonym: S-adenosyl-L-homocysteine hydrolase activity
has related synonym: SAHase activity

adenosylmethionine decarboxylase activity
type: Class
subclass of: GO_0016831
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + H(+) = S-adenosylmethioninamine + CO(2).
has exact synonym: adenosyl methionine decarboxylase activity
has related synonym: S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium-salt-forming]
has related synonym: S-adenosyl-L-methionine carboxy-lyase activity
has related synonym: S-adenosyl-L-methionine decarboxylase activity
has related synonym: S-adenosylmethionine decarboxylase activity

adenosylmethionine-8-amino-7-oxononanoate transaminase activity
type: Class
subclass of: GO_0008483
IAO_0000115: Catalysis of the reaction: 8-amino-7-oxononanoate + S-adenosyl-L-methionine(1+) = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoate.
has related synonym: 7,8-diaminonanoate transaminase activity
has related synonym: 7,8-diaminononanoate aminotransferase activity
has related synonym: 7,8-diaminononanoate transaminase activity
has related synonym: 7,8-diaminopelargonic acid aminotransferase activity
has related synonym: 7,8-diamino-pelargonic acid aminotransferase activity
has related synonym: 7-keto-8-aminopelargonic acid
has related synonym: 7-keto-8-aminopelargonic acid aminotransferase activity
has exact synonym: adenosylmethionine-8-amino-7-oxononanoate aminotransferase activity
has related synonym: adenosylmethionine--8-amino-7-oxononanoate aminotransferase activity
has exact synonym: adenosyl methionine-8-amino-7-oxononanoate transaminase activity
has related synonym: DAPA aminotransferase activity
has related synonym: DAPA transaminase activity
has related synonym: diaminopelargonate synthase activity
has related synonym: S-adenosyl-L-methionine:8-amino-7-oxononanoate aminotransferase activity

adenylate cyclase activity
type: Class
subclass of: GO_0009975
subclass of: GO_0016849
IAO_0000115: Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
has related synonym: 3',5'-cyclic AMP synthetase activity
has related synonym: adenyl cyclase activity
has related synonym: adenylylcyclase activity
has exact synonym: adenylyl cyclase activity
has related synonym: ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity
has related synonym: ATP diphosphate-lyase (cyclizing) activity
has related synonym: ATP pyrophosphate-lyase activity
has related synonym: cAMP generating peptide activity

adenylate kinase activity
type: Class
subclass of: GO_0050145
IAO_0000115: Catalysis of the reaction: ATP + AMP = 2 ADP.
has related synonym: 5'-AMP-kinase activity
has related synonym: adenylic kinase activity
has related synonym: adenylokinase activity
has related synonym: ATP:AMP phosphotransferase activity
has related synonym: myokinase activity

N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
type: Class
subclass of: GO_0016842
IAO_0000115: Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP.
has related synonym: 6-N-(1,2-dicarboxyethyl)AMP AMP-lyase activity
has related synonym: adenylosuccinase activity
has related synonym: adenylosuccinate lyase activity
has related synonym: N6-(1,2-dicarboxyethyl)AMP AMP-lyase activity
has related synonym: succino AMP-lyase activity

adenylosuccinate synthase activity
type: Class
subclass of: GO_0016879
IAO_0000115: Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate.
has related synonym: adenylosuccinate synthetase activity
has related synonym: IMP:L-aspartate ligase (GDP-forming)
has related synonym: IMP--aspartate ligase activity
has related synonym: succinoadenylic kinosynthetase activity
has related synonym: succino-AMP synthetase activity

adenylylsulfate kinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016773
IAO_0000115: Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate.
has related synonym: 5'-phosphoadenosine sulfate kinase activity
has related synonym: adenosine-5'-phosphosulfate-3'-phosphokinase activity
has exact synonym: adenosine-5'-phosphosulfate 3'-phosphotransferase activity
has related synonym: adenosine 5'-phosphosulfate kinase activity
has exact synonym: adenosine-5'-phosphosulphate 3'-phosphotransferase activity
has related synonym: adenosine phosphosulfate kinase activity
has related synonym: adenosine phosphosulfokinase activity
has related synonym: adenylylsulfate kinase (phosphorylating)
has exact synonym: adenylyl-sulfate kinase activity
has exact synonym: adenylyl-sulphate kinase activity
has related synonym: APS kinase activity
has related synonym: ATP:adenylyl-sulfate 3'-phosphotransferase activity

L-alanine:2-oxoglutarate aminotransferase activity
type: Class
subclass of: GO_0047635
IAO_0000115: Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate.
has related synonym: alanine-alpha-ketoglutarate aminotransferase activity
has related synonym: alanine aminotransferase activity
has related synonym: alanine-pyruvate aminotransferase activity
has related synonym: alanine transaminase activity
has related synonym: ALT
has related synonym: beta-alanine aminotransferase
has related synonym: glutamic acid-pyruvic acid transaminase activity
has related synonym: glutamic--alanine transaminase activity
has related synonym: glutamic-pyruvic aminotransferase activity
has related synonym: glutamic--pyruvic transaminase activity
has related synonym: GPT
has related synonym: L-alanine-alpha-ketoglutarate aminotransferase activity
has related synonym: L-alanine aminotransferase activity
has related synonym: L-alanine transaminase activity
has related synonym: pyruvate-alanine aminotransferase activity
has related synonym: pyruvate-glutamate transaminase activity
has related synonym: pyruvate transaminase activity

alcohol dehydrogenase (NAD+) activity
type: Class
subclass of: GO_0018455
IAO_0000115: Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+.
has related synonym: ADH
has related synonym: alcohol:NAD+ oxidoreductase
has related synonym: alcohol dehydrogenase activity
has related synonym: aldehyde dehydrogenase (NAD) activity
has exact synonym: aldo-keto reductase (NAD) activity
has related synonym: aliphatic alcohol dehydrogenase
has related synonym: ethanol dehydrogenase
has related synonym: NAD-dependent alcohol dehydrogenase
has related synonym: NADH-alcohol dehydrogenase
has related synonym: NADH-aldehyde dehydrogenase
has related synonym: NAD-specific aromatic alcohol dehydrogenase
has related synonym: primary alcohol dehydrogenase
has related synonym: yeast alcohol dehydrogenase

alcohol dehydrogenase activity, metal ion-independent
type: Class
subclass of: alcohol dehydrogenase (NAD+) activity
IAO_0000115: Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+; can proceed in the absence of a metal ion.

alcohol dehydrogenase activity, zinc-dependent
type: Class
subclass of: alcohol dehydrogenase (NAD+) activity
IAO_0000115: Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc.

alcohol dehydrogenase activity, iron-dependent
type: Class
subclass of: alcohol dehydrogenase (NAD+) activity
IAO_0000115: Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of iron.

alcohol O-acetyltransferase activity
type: Class
subclass of: GO_0016413
subclass of: GO_0034318
IAO_0000115: Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester.
has related synonym: AATASE activity
has related synonym: acetyl-CoA:alcohol O-acetyltransferase activity
has related synonym: alcohol acetyltransferase activity

alcohol sulfotransferase activity
type: Class
subclass of: GO_0008146
IAO_0000115: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate.
has related synonym: 3'-phosphoadenylyl-sulfate:alcohol sulfotransferase activity
has related synonym: 3beta-hydroxysteroid sulfotransferase activity
has related synonym: 3beta-hydroxy steroid sulfotransferase activity
has related synonym: 3-hydroxysteroid sulfotransferase activity
has related synonym: 5alpha-androstenol sulfotransferase activity
has related synonym: alcohol/hydroxysteroid sulfotransferase activity
has exact synonym: alcohol sulphotransferase activity
has related synonym: dehydroepiandrosterone sulfotransferase activity
has related synonym: delta5-3beta-hydroxysteroid sulfokinase activity
has related synonym: estrogen sulfokinase activity
has related synonym: estrogen sulfotransferase
has related synonym: HST
has related synonym: hydroxysteroid sulfotransferase activity
has related synonym: steroid alcohol sulfotransferase
has related synonym: steroid sulfokinase activity
has related synonym: sterol sulfokinase activity
has related synonym: sterol sulfotransferase activity

3-chloroallyl aldehyde dehydrogenase activity
type: Class
subclass of: GO_0016620
IAO_0000115: Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid.

aldehyde dehydrogenase (NAD+) activity
type: Class
subclass of: aldehyde dehydrogenase [NAD(P)+] activity
IAO_0000115: Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
has related synonym: aldehyde:NAD+ oxidoreductase activity
has related synonym: aldehyde dehydrogenase (NAD+)
has related synonym: CoA-independent aldehyde dehydrogenase activity
has related synonym: m-methylbenzaldehyde dehydrogenase activity
has related synonym: NAD-aldehyde dehydrogenase activity
has related synonym: NAD-dependent 4-hydroxynonenal dehydrogenase activity
has related synonym: NAD-dependent aldehyde dehydrogenase activity
has related synonym: NAD-linked aldehyde dehydrogenase activity
has related synonym: propionaldehyde dehydrogenase activity

aldehyde dehydrogenase [NAD(P)+] activity
type: Class
subclass of: GO_0016620
IAO_0000115: Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+.
has related synonym: aldehyde:NAD(P)+ oxidoreductase activity
has related synonym: ALDH

aldehyde oxidase activity
type: Class
subclass of: GO_0016623
IAO_0000115: Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide.
has related synonym: aldehyde:oxygen oxidoreductase activity
has related synonym: quinoline oxidase activity
has related synonym: retinal oxidase activity
replaces: GO_0050250

alditol:NADP+ 1-oxidoreductase activity
type: Class
subclass of: GO_0008106
IAO_0000115: Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
has related synonym: aldehyde reductase activity
has related synonym: aldose reductase activity
has related synonym: polyol dehydrogenase (NADP(+)) activity

aldo-keto reductase (NADP) activity
type: Class
subclass of: GO_0016616
IAO_0000115: Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.
has related synonym: alcohol dehydrogenase (NADP+) activity
has exact synonym: aldo-keto reductase (NADP+) activity
has exact synonym: aldo-keto reductase activity
has exact synonym: NADPH-dependent aldo-keto reductase activity

aldose 1-epimerase activity
type: Class
subclass of: GO_0016857
IAO_0000115: Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose.
has related synonym: aldose mutarotase activity
has related synonym: mutarotase activity

alkaline phosphatase activity
type: Class
subclass of: GO_0016791
IAO_0000115: Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.
has related synonym: alkaline phenyl phosphatase activity
has related synonym: alkaline phosphohydrolase activity
has related synonym: alkaline phosphomonoesterase activity
has related synonym: glycerophosphatase activity
has related synonym: orthophosphoric-monoester phosphohydrolase (alkaline optimum)
has related synonym: phosphate-monoester phosphohydrolase (alkaline optimum)
has related synonym: phosphomonoesterase activity

allantoicase activity
type: Class
subclass of: GO_0016813
IAO_0000115: Catalysis of the reaction: allantoate + H(2)O = (S)-ureidoglycolate + urea.
has related synonym: allantoate amidinohydrolase activity
has exact synonym: allantoine amidinohydrolase activity

allantoinase activity
type: Class
subclass of: GO_0016812
IAO_0000115: Catalysis of the reaction: allantoin + H2O = allantoate.
has related synonym: (S)-allantoin amidohydrolase activity

allophanate hydrolase activity
type: Class
subclass of: GO_0016811
IAO_0000115: Catalysis of the reaction: H(2)O + 3 H(+) + urea-1-carboxylate = 2 CO(2) + 2 NH(4)(+).
has related synonym: allophanate lyase activity
has related synonym: urea-1-carboxylate amidohydrolase activity

amidase activity
type: Class
subclass of: GO_0016811
IAO_0000115: Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3.
has exact synonym: acetamidase activity
has related synonym: acylamidase activity
has related synonym: acylamide amidohydrolase activity
has related synonym: acylase activity
has related synonym: amidohydrolase activity
has related synonym: fatty acylamidase activity
has related synonym: N-acetylaminohydrolase activity

acetyl-CoA:L-glutamate N-acetyltransferase activity
type: Class
subclass of: GO_0008080
IAO_0000115: Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+).
has related synonym: acetylglutamate acetylglutamate synthetase activity
has related synonym: AGAS
has related synonym: amino acid acetyltransferase activity
has related synonym: amino-acid N-acetyltransferase activity
has related synonym: N-acetylglutamate synthase activity

L-aminoadipate-semialdehyde dehydrogenase activity
type: Class
subclass of: GO_0016620
IAO_0000115: Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+.
has related synonym: 2-aminoadipate semialdehyde dehydrogenase activity
has related synonym: 2-aminoadipic semialdehyde dehydrogenase activity
has related synonym: AAR
has related synonym: alpha-aminoadipate reductase activity
has related synonym: alpha-aminoadipate-semialdehyde dehydrogenase activity
has related synonym: aminoadipate semialdehyde dehydrogenase activity
has related synonym: aminoadipate-semialdehyde dehydrogenase activity
has related synonym: L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase
has related synonym: L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase activity
has related synonym: L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity
has related synonym: L-alpha-aminoadipate delta-semialdehyde oxidoreductase activity

amidophosphoribosyltransferase activity
type: Class
subclass of: GO_0016763
IAO_0000115: Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H(2)O.
has related synonym: 5'-phosphoribosylpyrophosphate amidotransferase activity
has related synonym: 5-phosphoribosyl-1-pyrophosphate amidotransferase activity
has related synonym: 5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)
has related synonym: 5-phosphororibosyl-1-pyrophosphate amidotransferase activity
has related synonym: alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase activity
has related synonym: glutamine 5-phosphoribosylpyrophosphate amidotransferase activity
has related synonym: glutamine phosphoribosyldiphosphate amidotransferase activity
has related synonym: glutamine phosphoribosylpyrophosphate amidotransferase activity
has related synonym: glutamine ribosylpyrophosphate 5-phosphate amidotransferase activity
has related synonym: phosphoribose pyrophosphate amidotransferase activity
has related synonym: phosphoribosyldiphosphate 5-amidotransferase activity
has related synonym: phosphoribosyl pyrophosphate amidotransferase activity
has related synonym: phosphoribosylpyrophosphate glutamyl amidotransferase activity

aminoacyl-tRNA hydrolase activity
type: Class
subclass of: GO_0052689
subclass of: GO_0140101
IAO_0000115: Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.
has related synonym: aminoacyl-transfer ribonucleate hydrolase activity
has related synonym: aminoacyl-tRNA aminoacylhydrolase activity
has exact synonym: aminoacyl-tRNA hydrolase reaction
has related synonym: D-tyrosyl-tRNA hydrolase activity
has related synonym: N-substituted aminoacyl transfer RNA hydrolase activity
has related synonym: peptidyl-tRNA hydrolase activity
replaces: GO_0019850
replaces: GO_0019851

aminoacylase activity
type: Class
subclass of: GO_0016811
IAO_0000115: Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid.
has related synonym: acylase I activity
has related synonym: alpha-N-acylaminoacid hydrolase activity
has related synonym: amido acid deacylase activity
has related synonym: aminoacylase I activity
has related synonym: benzamidase activity
has related synonym: dehydropeptidase II activity
has related synonym: hippurase activity
has related synonym: histozyme activity
has related synonym: L-amino-acid acylase activity
has related synonym: L-aminoacylase activity
has related synonym: long acyl amidoacylase activity
has related synonym: N-acyl-L-amino-acid amidohydrolase activity
has related synonym: short acyl amidoacylase activity

aminomethyltransferase activity
type: Class
subclass of: GO_0016742
IAO_0000115: Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein.
has related synonym: glycine-cleavage system T-protein activity
has related synonym: glycine synthase activity
has related synonym: protein-8-S-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity
has related synonym: protein-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity
has related synonym: S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) activity
has related synonym: tetrahydrofolate aminomethyltransferase activity
has related synonym: T-protein

anthranilate phosphoribosyltransferase activity
type: Class
subclass of: GO_0016763
IAO_0000115: Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate.
has related synonym: anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase activity
has related synonym: anthranilate phosphoribosylpyrophosphate phosphoribosyltransferase activity
has related synonym: anthranilate-PP-ribose-P phosphoribosyltransferase activity
has related synonym: N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-alpha-D-ribosyltransferase activity
has related synonym: phosphoribosyl-anthranilate diphosphorylase activity
has related synonym: phosphoribosylanthranilate pyrophosphorylase activity
has related synonym: phosphoribosyl-anthranilate pyrophosphorylase activity
has related synonym: phosphoribosylanthranilate transferase activity
has related synonym: PRT

anthranilate synthase activity
type: Class
subclass of: GO_0016833
IAO_0000115: Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
has related synonym: anthranilate synthetase activity
has related synonym: chorismate pyruvate-lyase (amino-accepting) activity

obsolete apyrase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: ATP + 2 H2O = AMP + 2 phosphate.

arachidonate 5-lipoxygenase activity
type: Class
subclass of: GO_0016702
IAO_0000115: Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate.
has related synonym: 5Delta-lipoxygenase activity
has related synonym: 5-delta-lipoxygenase activity
has related synonym: 5-lipoxygenase activity
has related synonym: arachidonate:oxygen 5-oxidoreductase activity
has related synonym: arachidonic 5-lipoxygenase activity
has related synonym: arachidonic acid 5-lipoxygenase activity
has related synonym: C-5-lipoxygenase activity
has related synonym: delta(5)-lipoxygenase activity
has related synonym: delta5-lipoxygenase activity
has related synonym: leukotriene-A(4) synthase activity
has related synonym: leukotriene A4 synthase
has related synonym: leukotriene-A4 synthase activity
has related synonym: LTA synthase activity

arachidonate 12(S)-lipoxygenase activity
type: Class
subclass of: GO_0016702
IAO_0000115: Catalysis of the reaction: arachidonate + O(2) = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate.
has related synonym: 12Delta-lipoxygenase activity
has related synonym: 12-lipoxygenase activity
has related synonym: 12S-lipoxygenase activity
has related synonym: arachidonate:oxygen 12-oxidoreductase activity
has related synonym: C-12 lipoxygenase activity
has related synonym: delta12-lipoxygenase activity
has related synonym: leukotriene A4 synthase
has related synonym: LTA4 synthase activity

arginase activity
type: Class
subclass of: GO_0016813
IAO_0000115: Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea.
has related synonym: arginine amidinase activity
has related synonym: arginine transamidinase activity
has related synonym: canavanase activity
has related synonym: L-arginase activity
has related synonym: L-arginine amidinohydrolase activity

arginine kinase activity
type: Class
subclass of: GO_0016775
subclass of: GO_0019202
IAO_0000115: Catalysis of the reaction: L-arginine + ATP = N(omega)-phospho-L-arginine + ADP + 2 H(+).
has related synonym: adenosine 5'-triphosphate:L-arginine
has related synonym: adenosine 5'-triphosphate-arginine phosphotransferase activity
has related synonym: arginine phosphokinase activity
has related synonym: ATP:L-arginine N-phosphotransferase activity

argininosuccinate synthase activity
type: Class
subclass of: GO_0016879
IAO_0000115: Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate.
has related synonym: arginine succinate synthetase activity
has related synonym: argininosuccinate synthetase activity
has related synonym: argininosuccinic acid synthetase activity
has related synonym: arginosuccinate synthetase activity
has related synonym: citrulline--aspartate ligase activity
has related synonym: L-citrulline:L-aspartate ligase (AMP-forming)

argininosuccinate lyase activity
type: Class
subclass of: GO_0016842
IAO_0000115: Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine.
has related synonym: 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)
has related synonym: 2-(omega-N-L-arginino)succinate arginine-lyase (fumarate-forming)
has related synonym: arginine-succinate lyase activity
has related synonym: argininosuccinic acid lyase activity
has related synonym: arginosuccinase activity
has related synonym: N-(L-argininosuccinate) arginine-lyase activity
has related synonym: omega-N-(L-arginino)succinate arginine-lyase activity

arginyltransferase activity
type: Class
subclass of: GO_0016755
subclass of: part-of-parent-16598
IAO_0000115: Catalysis of the reaction: L-arginyl-tRNA + protein = tRNA + L-arginyl-protein.
has related synonym: arginine transferase activity
has related synonym: arginyl-transfer ribonucleate-protein aminoacyltransferase activity
has related synonym: arginyl-transfer ribonucleate-protein transferase activity
has related synonym: arginyl-tRNA protein transferase activity
has exact synonym: arginyl-tRNA-protein transferase activity
has related synonym: arginyl-tRNA--protein transferase activity
has related synonym: L-arginyl-tRNA:protein arginyltransferase activity
replaces: GO_0042172

aromatic-L-amino-acid decarboxylase activity
type: Class
subclass of: GO_0016831
IAO_0000115: Catalysis of the reaction: L-amino acid + H+ = R-H + CO2.
has related synonym: 5-hydroxytryptophan decarboxylase activity
has related synonym: aromatic amino acid decarboxylase activity
has related synonym: aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)
has related synonym: aromatic-L-amino-acid carboxy-lyase activity
has related synonym: DOPA decarboxylase activity
has related synonym: hydroxytryptophan decarboxylase activity
has related synonym: L-DOPA decarboxylase activity
has related synonym: tryptophan decarboxylase activity
replaces: GO_0016400

aralkylamine N-acetyltransferase activity
type: Class
subclass of: GO_0008080
IAO_0000115: Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine.
has related synonym: AANAT activity
has related synonym: acetyl-CoA:2-arylethylamine N-acetyltransferase activity
has related synonym: arylalkylamine N-acetyltransferase activity
has related synonym: melatonin rhythm enzyme activity
has related synonym: serotonin acetylase activity
has related synonym: serotonin acetyltransferase activity
has related synonym: serotonin N-acetyltransferase activity

arylamine N-acetyltransferase activity
type: Class
subclass of: GO_0008080
IAO_0000115: Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.
has related synonym: 2-naphthylamine N-acetyltransferase activity
has related synonym: 4-aminobiphenyl N-acetyltransferase activity
has related synonym: acetyl-CoA:arylamine N-acetyltransferase activity
has related synonym: acetyl CoA-arylamine N-acetyltransferase activity
has related synonym: arylamine acetylase activity
has related synonym: arylamine acetyltransferase activity
has related synonym: beta-naphthylamine N-acetyltransferase activity
has related synonym: indoleamine N-acetyltransferase activity
has related synonym: p-aminosalicylate N-acetyltransferase activity

arylformamidase activity
type: Class
subclass of: GO_0016811
IAO_0000115: Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine.
has related synonym: aryl-formylamine amidohydrolase activity
has related synonym: formamidase I
has related synonym: formamidase II
has related synonym: formylase activity
has related synonym: formylkynureninase activity
has related synonym: formylkynurenine formamidase activity
has related synonym: kynurenine formamidase activity

aryl sulfotransferase activity
type: Class
subclass of: GO_0008146
IAO_0000115: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.
has related synonym: 1-naphthol phenol sulfotransferase activity
has related synonym: 2-naphtholsulfotransferase activity
has related synonym: 3'-phosphoadenylyl-sulfate:phenol sulfotransferase activity
has related synonym: 4-nitrocatechol sulfokinase activity
has related synonym: arylsulfotransferase
has exact synonym: aryl sulphotransferase activity
has related synonym: dopamine sulfotransferase activity
has related synonym: phenol sulfokinase activity
has related synonym: phenol sulfotransferase activity
has related synonym: p-nitrophenol sulfotransferase activity
has related synonym: PST
has related synonym: ritodrine sulfotransferase activity
has related synonym: sulfokinase activity

aryldialkylphosphatase activity
type: Class
subclass of: GO_0016791
IAO_0000115: Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol.
has related synonym: A-esterase activity
has related synonym: aryltriphosphatase activity
has exact synonym: aryltriphosphate dialkylphosphohydrolase activity
has related synonym: esterase B1
has related synonym: esterase E4
has related synonym: OPH
has related synonym: organophosphate esterase activity
has related synonym: organophosphate hydrolase activity
has related synonym: organophosphorus acid anhydrase activity
has related synonym: organophosphorus hydrolase activity
has related synonym: paraoxonase activity
has related synonym: paraoxon esterase activity
has related synonym: paraoxon hydrolase activity
has related synonym: phosphotriesterase activity
has related synonym: pirimiphos-methyloxon esterase activity

arylesterase activity
type: Class
subclass of: GO_0052689
IAO_0000115: Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate.
has related synonym: A-esterase activity
has related synonym: aromatic esterase
has related synonym: aryl-ester hydrolase
has related synonym: paraoxonase activity

arylsulfatase activity
type: Class
subclass of: GO_0008484
IAO_0000115: Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate.
has related synonym: 4-methylumbelliferyl sulfatase activity
has related synonym: aryl-sulfate sulfohydrolase activity
has related synonym: aryl-sulfate sulphohydrolase activity
has related synonym: arylsulfohydrolase activity
has exact synonym: arylsulphatase activity
has related synonym: aryl-sulphate sulphohydrolase activity
has related synonym: estrogen sulfatase activity
has related synonym: nitrocatechol sulfatase activity
has related synonym: phenolsulfatase activity
has related synonym: phenylsulfatase activity
has related synonym: p-nitrophenyl sulfatase activity
has related synonym: sulfatase activity

asparagine synthase (glutamine-hydrolyzing) activity
type: Class
subclass of: GO_0016884
IAO_0000115: Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate.
has related synonym: AS
has related synonym: AS-B activity
has related synonym: asparagine synthase (glutamine-hydrolysing)
has related synonym: asparagine synthetase (glutamine-hydrolysing)
has related synonym: asparagine synthetase (glutamine-hydrolyzing) activity
has related synonym: asparagine synthetase B activity
has related synonym: glutamine-dependent asparagine synthetase activity
has related synonym: L-aspartate:L-glutamine amido-ligase (AMP-forming)

asparaginase activity
type: Class
subclass of: GO_0016811
IAO_0000115: Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3.
has related synonym: alpha-asparaginase activity
has related synonym: asparaginase II
has related synonym: colaspase activity
has related synonym: crasnitin
has related synonym: elspar
has related synonym: L-asparaginase activity
has related synonym: L-asparagine amidohydrolase activity
has related synonym: leunase activity

aspartate 1-decarboxylase activity
type: Class
subclass of: GO_0016831
IAO_0000115: Catalysis of the reaction: L-aspartate = beta-alanine + CO2.
has related synonym: aspartate alpha-decarboxylase activity
has related synonym: aspartic alpha-decarboxylase
has related synonym: L-aspartate 1-carboxy-lyase (beta-alanine-forming)
has related synonym: L-aspartate 1-carboxy-lyase activity
has related synonym: L-aspartate alpha-decarboxylase activity

L-aspartate:2-oxoglutarate aminotransferase activity
type: Class
subclass of: GO_0008483
IAO_0000115: Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
has related synonym: 2-oxoglutarate-glutamate aminotransferase activity
has related synonym: AAT
has related synonym: aspartate:2-oxoglutarate aminotransferase activity
has related synonym: aspartate-2-oxoglutarate transaminase activity
has related synonym: aspartate alpha-ketoglutarate transaminase activity
has related synonym: aspartate aminotransferase activity
has related synonym: aspartate transaminase activity
has related synonym: aspartic acid aminotransferase activity
has related synonym: aspartic aminotransferase activity
has related synonym: aspartyl aminotransferase activity
has related synonym: AspT
has related synonym: glutamate-oxalacetate aminotransferase activity
has related synonym: glutamate-oxalate transaminase activity
has related synonym: glutamate oxaloacetate transaminase activity
has related synonym: glutamic-aspartic aminotransferase activity
has related synonym: glutamic--aspartic transaminase activity
has related synonym: glutamic-oxalacetic transaminase activity
has related synonym: glutamic oxalic transaminase activity
has related synonym: glutamic--oxaloacetic transaminase activity
has related synonym: GOT (enzyme)
has related synonym: L-aspartate-2-ketoglutarate aminotransferase activity
has related synonym: L-aspartate-2-oxoglutarate aminotransferase activity
has related synonym: L-aspartate-2-oxoglutarate-transaminase activity
has related synonym: L-aspartate-alpha-ketoglutarate transaminase activity
has related synonym: L-aspartate transaminase activity
has related synonym: L-aspartic aminotransferase activity
has related synonym: oxaloacetate-aspartate aminotransferase activity
has related synonym: oxaloacetate transferase activity
has related synonym: transaminase A activity

aspartate carbamoyltransferase activity
type: Class
subclass of: GO_0016743
IAO_0000115: Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate.
has related synonym: aspartate carbamyltransferase activity
has related synonym: aspartate transcarbamoylase activity
has related synonym: aspartate transcarbamylase activity
has related synonym: aspartic acid transcarbamoylase activity
has related synonym: aspartic carbamyltransferase activity
has related synonym: aspartic transcarbamylase activity
has related synonym: ATCase activity
has related synonym: carbamoylaspartotranskinase activity
has related synonym: carbamoyl-phosphate:L-aspartate carbamoyltransferase activity
has related synonym: carbamylaspartotranskinase activity
has related synonym: L-aspartate transcarbamoylase activity
has related synonym: L-aspartate transcarbamylase activity

aspartate-ammonia ligase activity
type: Class
subclass of: GO_0016211
IAO_0000115: Catalysis of the reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine.
has related synonym: asparagine synthetase activity
has related synonym: L-asparagine synthetase activity
has related synonym: L-aspartate:ammonia ligase (AMP-forming)

aspartate kinase activity
type: Class
subclass of: GO_0016774
subclass of: GO_0019202
IAO_0000115: Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H(+).
has related synonym: aspartic kinase activity
has related synonym: aspartokinase activity
has related synonym: ATP:L-aspartate 4-phosphotransferase activity
has related synonym: beta-aspartokinase activity

aspartate-semialdehyde dehydrogenase activity
type: Class
subclass of: GO_0016620
IAO_0000115: Catalysis of the reaction: L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH.
has related synonym: ASA dehydrogenase activity
has related synonym: aspartate semialdehyde dehydrogenase activity
has related synonym: aspartic beta-semialdehyde dehydrogenase activity
has related synonym: aspartic semialdehyde dehydrogenase activity
has related synonym: L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)
has related synonym: L-aspartate-beta-semialdehyde:NADP oxidoreductase (phosporylating)
has related synonym: L-aspartate-beta-semialdehyde dehydrogenase activity

biliverdin reductase (NAD(P)+) activity
type: Class
subclass of: GO_0016628
IAO_0000115: Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+.
has related synonym: bilirubin:NAD(P)+ oxidoreductase activity

biotin carboxylase activity
type: Class
subclass of: GO_0016879
IAO_0000115: Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein.
has related synonym: biotin carboxylase (component of acetyl CoA carboxylase) activity
has related synonym: biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming) activity

biotin synthase activity
type: Class
subclass of: GO_0016783
IAO_0000115: Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H(+).
has related synonym: biotin synthetase activity
has related synonym: dethiobiotin:sulfur sulfurtransferase activity

biotin-[acetyl-CoA-carboxylase] ligase activity
type: Class
subclass of: GO_0018271
IAO_0000115: Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming)).
has related synonym: acetyl-CoA carboxylase biotin holoenzyme synthetase activity
has related synonym: acetyl CoA holocarboxylase synthetase activity
has related synonym: acetyl coenzyme A holocarboxylase synthetase activity
has related synonym: biotin:apo-acetyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)
has related synonym: biotin:apocarboxylase ligase activity
has related synonym: biotin--[acetyl-CoA carboxylase] synthetase activity
has related synonym: biotin-acetyl-CoA-carboxylase ligase activity
has related synonym: biotin-acetyl-CoA carboxylase synthetase
has related synonym: biotin-acetyl coenzyme A carboxylase synthetase activity
has related synonym: biotin holoenzyme synthetase activity
has related synonym: biotin--protein ligase activity
has related synonym: HCS

biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity
type: Class
subclass of: GO_0018271
IAO_0000115: Catalysis of the reaction: ATP + biotin + apo-(3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)).
has related synonym: beta-methylcrotonyl coenzyme A holocarboxylase synthetase activity
has related synonym: biotin:apo-3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)
has related synonym: biotin--[methylcrotonoyl-CoA-carboxylase] synthetase activity
has related synonym: biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase activity
has related synonym: biotin-methylcrotonoyl-CoA-carboxylase ligase activity
has related synonym: biotin-methylcrotonoyl-CoA-carboxylase synthetase

biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity
type: Class
subclass of: GO_0018271
IAO_0000115: Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase).
has related synonym: biotin:apomethylmalonyl-CoA:pyruvate carboxyltransferase ligase (AMP-forming)
has related synonym: biotin:apomethylmalonyl-CoA:pyruvate carboxytransferase ligase (AMP-forming)
has exact synonym: biotin-[methylmalonyl-CoA-carboxyltransferase] ligase activity
has related synonym: biotin--[methylmalonyl-CoA-carboxyltransferase] ligase activity
has related synonym: biotin--[methylmalonyl-CoA-carboxyltransferase] synthetase activity
has related synonym: biotin--[methylmalonyl-CoA-carboxytransferase] synthetase activity
has related synonym: biotin-methylmalonyl-CoA-carboxyltransferase ligase activity
has related synonym: biotin-methylmalonyl-CoA-carboxyltransferase synthetase
has related synonym: biotin-methylmalonyl-CoA-carboxytransferase ligase activity
has related synonym: biotin-methylmalonyl-CoA-carboxytransferase synthetase activity
has related synonym: biotin-methylmalonyl coenzyme A carboxyltransferase synthetase activity
has related synonym: biotin-transcarboxylase synthetase activity
has related synonym: methylmalonyl coenzyme A holotranscarboxylase synthetase activity

biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity
type: Class
subclass of: GO_0018271
IAO_0000115: Catalysis of the reaction: ATP + biotin + apo-(propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (propanoyl-CoA:carbon-dioxide ligase (ADP-forming)).
has related synonym: biotin:apo-propanoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)
has related synonym: biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] synthetase activity
has related synonym: biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) ligase activity
has related synonym: biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) synthetase activity
has related synonym: biotin-propionyl coenzyme A carboxylase synthetase activity
has related synonym: holocarboxylase synthetase activity
has related synonym: propionyl-CoA holocarboxylase synthetase activity
has related synonym: propionyl coenzyme A holocarboxylase synthetase activity

bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
type: Class
subclass of: GO_0008796
IAO_0000115: Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate.
has related synonym: 1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity
has related synonym: Ap(4)Aase activity
has related synonym: Ap(4)A hydrolase activity
has related synonym: Ap4Aase activity
has related synonym: Ap4A hydrolase activity
has related synonym: bis(5'-adenosyl)-tetraphosphatase activity
has related synonym: bis(5'-guanosyl)-tetraphosphatase activity
has related synonym: diadenosine 5',5'''-P(1),P(4)-tetraphosphate asymmetrical hydrolase activity
has related synonym: diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase activity
has related synonym: diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase
has related synonym: diadenosine P1,P4-tetraphosphatase activity
has related synonym: diadenosinetetraphosphatase (asymmetrical) activity
has related synonym: diguanosinetetraphosphatase (asymmetrical) activity
has related synonym: dinucleosidetetraphosphatase (asymmetrical) activity
has related synonym: dinucleoside tetraphosphatase activity
has related synonym: P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity

bisphosphoglycerate mutase activity
type: Class
subclass of: GO_0016868
IAO_0000115: Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate.
has related synonym: 2,3-bisphosphoglycerate mutase activity
has related synonym: 2,3-bisphosphoglycerate synthase activity
has related synonym: 2,3-diphosphoglycerate mutase activity
has related synonym: 2,3-diphosphoglycerate synthase activity
has related synonym: 2,3-diphosphoglyceromutase activity
has related synonym: 3-phospho-D-glycerate 1,2-phosphomutase activity
has related synonym: biphosphoglycerate synthase activity
has related synonym: bisphosphoglycerate synthase activity
has related synonym: bisphosphoglyceromutase
has related synonym: BPGM activity
has related synonym: diphosphoglycerate mutase activity
has related synonym: diphosphoglyceric mutase activity
has related synonym: diphosphoglyceromutase activity
has related synonym: DPGM
has related synonym: glycerate phosphomutase activity

bisphosphoglycerate 2-phosphatase activity
type: Class
subclass of: GO_0034416
IAO_0000115: Catalysis of the reaction: 2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphate.
has related synonym: 2,3-bisphospho-D-glycerate 2-phosphohydrolase activity

branched-chain-amino-acid transaminase activity
type: Class
subclass of: GO_0008483
IAO_0000115: Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid.
has related synonym: branched-chain-amino-acid:2-oxoglutarate aminotransferase activity
has exact synonym: branched-chain amino acid aminotransferase activity
has related synonym: branched-chain amino acid-glutamate transaminase activity
has related synonym: branched-chain aminotransferase activity
has related synonym: glutamate-branched-chain amino acid transaminase activity
has related synonym: L-branched chain amino acid aminotransferase activity
has related synonym: transaminase B activity

butyryl-CoA dehydrogenase activity
type: Class
subclass of: acyl-CoA dehydrogenase activity
IAO_0000115: Catalysis of the reaction: butanoyl-CoA + electron-transfer flavoprotein = 2-butenoyl-CoA + reduced electron-transfer flavoprotein.
has related synonym: 3-hydroxyacyl CoA reductase activity
has related synonym: butanoyl-CoA:(acceptor) 2,3-oxidoreductase activity
has related synonym: butanoyl-CoA:acceptor 2,3-oxidoreductase activity
has related synonym: butyryl coenzyme A dehydrogenase activity
has related synonym: butyryl dehydrogenase activity
has related synonym: enoyl-coenzyme A reductase activity
has related synonym: ethylene reductase activity
has related synonym: short-chain acyl CoA dehydrogenase activity
has related synonym: short-chain-acyl-CoA dehydrogenase activity
has related synonym: short-chain acyl-coenzyme A dehydrogenase activity
has related synonym: unsaturated acyl-CoA reductase activity
has related synonym: unsaturated acyl coenzyme A reductase activity

obsolete carbamoyl-phosphate synthase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of a reaction that results in the formation of carbamoyl phosphate.

carbamoyl-phosphate synthase (ammonia) activity
type: Class
subclass of: GO_0016879
IAO_0000115: Catalysis of the reaction: 2 ATP + CO(2) + H(2)O + NH(4)(+) = 2 ADP + carbamoyl phosphate + 5 H(+) + phosphate.
has related synonym: carbamoylphosphate synthase (ammonia)
has exact synonym: carbamoyl phosphate synthase (ammonia) activity
has related synonym: carbamoylphosphate synthase activity
has related synonym: carbamoylphosphate synthetase (ammonia) activity
has related synonym: carbamoyl-phosphate synthetase (ammonia) activity
has related synonym: carbamoyl-phosphate synthetase I activity
has related synonym: carbamylphosphate synthetase activity
has related synonym: carbamylphosphate synthetase I
has related synonym: carbmoylphosphate synthetase activity
has related synonym: carbon-dioxide:ammonia ligase (ADP-forming, carbamate-phosphorylating)
has related synonym: carbon-dioxide--ammonia ligase activity
has related synonym: CPS I activity

carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
type: Class
subclass of: GO_0016884
IAO_0000115: Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate.
has related synonym: carbamoyl-phosphate synthase (glutamine-hydrolysing) activity
has exact synonym: carbamoyl phosphate synthase (glutamine-hydrolyzing) activity
has related synonym: carbamoyl-phosphate synthetase (glutamine-hydrolysing) activity
has related synonym: carbamoyl-phosphate synthetase (glutamine-hydrolyzing) activity
has related synonym: carbamoyl phosphate synthetase activity
has related synonym: carbamoylphosphate synthetase II activity
has related synonym: carbamyl phosphate synthetase (glutamine) activity
has related synonym: carbon-dioxide::L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity
has related synonym: CPS activity
has related synonym: GD-CPSase activity
has related synonym: glutamine-dependent carbamoyl-phosphate synthase activity
has related synonym: glutamine-dependent carbamyl phosphate synthetase activity
has related synonym: hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity

carbonate dehydratase activity
type: Class
subclass of: GO_0016836
IAO_0000115: Catalysis of the reaction: H2CO3 = CO2 + H2O.
has related synonym: anhydrase activity
has related synonym: carbonate anhydrase activity
has related synonym: carbonate hydro-lyase (carbon-dioxide-forming)
has related synonym: carbonate hydro-lyase activity
has related synonym: carbonic acid anhydrase activity
has related synonym: carbonic anhydrase A
has exact synonym: carbonic anhydrase activity
has related synonym: carbonic dehydratase activity
has related synonym: carboxyanhydrase activity

carbonyl reductase (NADPH) activity
type: Class
subclass of: GO_0016616
IAO_0000115: Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+.
has related synonym: aldehyde reductase 1
has related synonym: aldehyde reductase I activity
has related synonym: ALR3
has related synonym: carbonyl reductase activity
has related synonym: NADPH2-dependent carbonyl reductase activity
has related synonym: NADPH-dependent carbonyl reductase activity
has related synonym: nonspecific NADPH-dependent carbonyl reductase activity
has related synonym: prostaglandin 9-ketoreductase activity
has related synonym: secondary-alcohol:NADP+ oxidoreductase activity
has related synonym: xenobiotic ketone reductase activity

carnitine O-acetyltransferase activity
type: Class
subclass of: GO_0016406
subclass of: GO_0016413
IAO_0000115: Catalysis of the reaction: acetyl-CoA + carnitine = (R)-O-acetylcarnitine + CoA.
has related synonym: acetylcarnitine transferase activity
has related synonym: acetyl-CoA:carnitine O-acetyltransferase activity
has related synonym: acetyl-CoA-carnitine O-acetyltransferase activity
has related synonym: carnitine acetylase activity
has related synonym: carnitine-acetyl-CoA transferase activity
has related synonym: carnitine acetyl coenzyme A transferase activity
has related synonym: carnitine acetyltransferase activity
has related synonym: carnitine O-acetyltransferase I activity
has related synonym: carnitine O-acetyltransferase II activity
has related synonym: CATC
replaces: GO_0004093
replaces: GO_0004094

carnitine O-palmitoyltransferase activity
type: Class
subclass of: GO_0016406
subclass of: GO_0016416
IAO_0000115: Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.
has related synonym: acylcarnitine transferase activity
has related synonym: carnitine palmitoyltransferase-A
has related synonym: carnitine palmitoyltransferase activity
has related synonym: carnitine palmitoyltransferase I
has related synonym: carnitine palmitoyltransferase II
has related synonym: CPT
has related synonym: CPT-A
has related synonym: CPT-B
has related synonym: CPTi
has related synonym: CPT I (outer membrane carnitine palmitoyl transferase)
has related synonym: CPTo
has related synonym: L-carnitine palmitoyltransferase activity
has related synonym: outer malonyl-CoA inhibitable carnitine palmitoyltransferase activity
has related synonym: palmitoylcarnitine transferase activity
has related synonym: palmitoyl-CoA:L-carnitine O-palmitoyltransferase activity

catalase activity
type: Class
subclass of: peroxidase activity
IAO_0000115: Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O.
has related synonym: bacterial catalase-peroxidase activity
has related synonym: caperase activity
has related synonym: CAT
has related synonym: catalase-peroxidase activity
has exact synonym: catalase reaction
has related synonym: equilase activity
has related synonym: haem catalase activity
has related synonym: heme catalase activity
has related synonym: hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity
has related synonym: manganese catalase activity
has related synonym: optidase activity
replaces: GO_0016952
replaces: GO_0016953

catechol oxidase activity
type: Class
subclass of: monooxygenase activity
subclass of: GO_0016682
IAO_0000115: Catalysis of the reaction: 2 L-dopa + O2 = 2 H2O + 2 L-dopaquinone. This reaction catalyzes exclusively the oxidation of catechols (i.e., o-diphenols) to the corresponding o-quinones.
has exact synonym: catecholase
has exact synonym: diphenol oxidase activity
has related synonym: dopamine monooxygenase activity
has related synonym: L-DOPA monooxygenase activity
has related synonym: L-dopa oxidase activity
has exact synonym: o-diphenolase activity
has exact synonym: o-diphenol oxidoreductase
has related synonym: phenolase activity
has related synonym: polyphenol oxidase activity
has related synonym: pyrocatechol oxidase
has related synonym: tyrosinase activity
replaces: GO_0036263
replaces: GO_0036264
replaces: GO_0102316

cerebroside-sulfatase activity
type: Class
subclass of: GO_0008484
IAO_0000115: Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + sulfate.
has related synonym: arylsulfatase A activity
has related synonym: cerebroside-3-sulfate 3-sulfohydrolase activity
has related synonym: cerebroside sulfate sulfatase activity
has exact synonym: cerebroside-sulphatase activity

chitin deacetylase activity
type: Class
subclass of: GO_0016811
subclass of: GO_0019213
IAO_0000115: Catalysis of the reaction: chitin + H2O = chitosan + acetate.
has related synonym: chitin amidohydrolase activity

chitin synthase activity
type: Class
subclass of: GO_0008375
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n) = UDP + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n+1).
has related synonym: chitin synthetase activity
has related synonym: chitin-UDP acetyl-glucosaminyl transferase activity
has related synonym: chitin-UDP N-acetylglucosaminyltransferase activity
has related synonym: chitin-uridine diphosphate acetylglucosaminyltransferase activity
has related synonym: trans-N-acetylglucosaminosylase activity
has related synonym: UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase activity

choline O-acetyltransferase activity
type: Class
subclass of: GO_0016413
IAO_0000115: Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA.
has related synonym: acetyl-CoA:choline O-acetyltransferase activity
has related synonym: CHOACTase activity
has related synonym: choline acetylase activity
has related synonym: choline acetyltransferase activity

choline kinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016773
subclass of: part-of-parent-6657
IAO_0000115: Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H(+).
has related synonym: ATP:choline phosphotransferase activity
has related synonym: choline-ethanolamine kinase activity
has related synonym: choline kinase (phosphorylating)
has related synonym: choline phosphokinase activity

cholinesterase activity
type: Class
subclass of: GO_0052689
IAO_0000115: Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion.
has related synonym: acylcholine acylhydrolase activity
has related synonym: anticholineesterase activity
has related synonym: benzoylcholinesterase activity
has related synonym: BtChoEase activity
has related synonym: butyrylcholine esterase activity
has related synonym: butyrylcholinesterase activity
has related synonym: choline esterase activity
has related synonym: choline esterase II (unspecific) activity
has related synonym: non-specific cholinesterase activity
has related synonym: propionylcholinesterase activity
has related synonym: pseudocholinesterase activity

choline-phosphate cytidylyltransferase activity
type: Class
subclass of: GO_0070567
subclass of: part-of-parent-6657
IAO_0000115: Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline.
has related synonym: CDP-choline pyrophosphorylase activity
has related synonym: CDP-choline synthetase activity
has related synonym: choline phosphate cytidylyltransferase activity
has exact synonym: CTP:choline-phosphate cytidylyltransferase activity
has related synonym: CTP:phosphocholine cytidylyltransferase activity
has related synonym: CTP:phosphorylcholine cytidylyltransferase activity
has related synonym: CTP-phosphocholine cytidylyltransferase activity
has related synonym: cytidine diphosphocholine pyrophosphorylase activity
has related synonym: phosphocholine cytidylyltransferase activity
has related synonym: phosphorylcholine:CTP cytidylyltransferase activity
has related synonym: phosphorylcholine cytidylyltransferase activity
has related synonym: phosphorylcholine transferase activity

chorismate mutase activity
type: Class
subclass of: GO_0016866
IAO_0000115: Catalysis of the reaction: chorismate = prephenate.
has related synonym: chorismate pyruvatemutase activity
has related synonym: hydroxyphenylpyruvate synthase activity

chorismate synthase activity
type: Class
subclass of: GO_0016838
IAO_0000115: Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate.
has related synonym: 5-enolpyruvylshikimate-3-phosphate phospholyase activity
has related synonym: 5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase (chorismate-forming)
has related synonym: 5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase activity

citrate (Si)-synthase activity
type: Class
subclass of: GO_0036440
IAO_0000115: Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group.
has related synonym: (R)-citric synthase activity
has related synonym: acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming]
has related synonym: citrate condensing enzyme activity
has related synonym: citrate oxaloacetate-lyase, CoA-acetylating activity
has related synonym: citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity
has related synonym: citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA)
has related synonym: citrate oxaloacetate-lyase [(pro-3S)-CH2COOrightacetyl-CoA]
has related synonym: citrate synthase activity
has related synonym: citrate synthetase activity
has related synonym: citric-condensing enzyme activity
has related synonym: citric synthase activity
has related synonym: citrogenase activity
has related synonym: condensing enzyme activity
has related synonym: oxalacetic transacetase activity
has related synonym: oxaloacetate transacetase activity

coproporphyrinogen oxidase activity
type: Class
subclass of: GO_0016634
IAO_0000115: Catalysis of the reaction: coproporphyrinogen III + 2 H(+) + O(2) = 2 CO(2) + 2 H(2)O + protoporphyrinogen IX.
has exact synonym: coprogen oxidase activity
has related synonym: coproporphyrinogen:oxygen oxidoreductase (decarboxylating)
has exact synonym: coproporphyrinogenase activity
has exact synonym: coproporphyrinogen-III oxidase activity

corticosteroid side-chain-isomerase activity
type: Class
subclass of: GO_0016861
IAO_0000115: Catalysis of the reaction: 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al.
has related synonym: 11-deoxycorticosterone aldose-ketose-isomerase activity
has related synonym: 11-deoxycorticosterone ketol-isomerase activity

creatine kinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016775
IAO_0000115: Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+).
has related synonym: adenosine triphosphate-creatine transphosphorylase activity
has related synonym: ATP:creatine N-phosphotransferase activity
has related synonym: ATP:creatine phosphotransferase activity
has related synonym: BB-CK
has related synonym: CK
has related synonym: CK-BB
has related synonym: CK-MB
has related synonym: CKMiMi
has related synonym: CK-MM
has related synonym: creatine phosphokinase activity
has related synonym: creatine phosphotransferase activity
has related synonym: MB-CK
has related synonym: Mi-CK
has related synonym: MiMi-CK
has related synonym: MM-CK
has related synonym: phosphocreatine kinase activity

cyclic-nucleotide phosphodiesterase activity
type: Class
subclass of: GO_0008081
IAO_0000115: Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate.

2',3'-cyclic-nucleotide 3'-phosphodiesterase activity
type: Class
subclass of: cyclic-nucleotide phosphodiesterase activity
IAO_0000115: Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate.
has related synonym: 2',3'-cyclic AMP phosphodiesterase activity
has related synonym: 2',3'-cyclic nucleoside monophosphate phosphodiesterase
has exact synonym: 2',3'-cyclic nucleotide 3'-phosphodiesterase activity
has related synonym: 2',3'-cyclic nucleotide 3'-phosphohydrolase activity
has related synonym: 2',3'-cyclic nucleotide phosphohydrolase
has related synonym: 2':3'-CNMP-3'-ase activity
has related synonym: 2':3'-cyclic nucleotide 3'-phosphodiesterase activity
has related synonym: CNPase activity
has related synonym: cyclic 2',3'-nucleotide 3'-phosphodiesterase activity
has related synonym: cyclic 2',3'-nucleotide phosphodiesterase
has related synonym: cyclic-CMP phosphodiesterase activity
has related synonym: nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase activity

3',5'-cyclic-nucleotide phosphodiesterase activity
type: Class
subclass of: cyclic-nucleotide phosphodiesterase activity
IAO_0000115: Catalysis of the reaction: a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate.
has related synonym: 3', 5'-cyclic nucleoside monophosphate phosphodiesterase activity
has related synonym: 3',5'-cyclic-nucleotide 5'-nucleotidohydrolase activity
has exact synonym: 3',5' cyclic-nucleotide phosphodiesterase activity
has related synonym: 3',5'-cyclonucleotide phosphodiesterase activity
has related synonym: 3',5'-nucleotide phosphodiesterase activity
has related synonym: 3':5'-cyclic nucleotide 5'-nucleotidohydrolase activity
has related synonym: 3': 5'-monophosphate phosphodiesterase (cyclic CMP) activity
has related synonym: cyclic 3',5'-mononucleotide phosphodiesterase activity
has related synonym: cyclic 3',5'-nucleotide phosphodiesterase activity
has related synonym: cyclic 3',5'-phosphodiesterase activity
has related synonym: cyclic 3',5-nucleotide monophosphate phosphodiesterase activity
has related synonym: cyclic AMP phosphodiesterase activity
has related synonym: cyclic nucleotide phosphodiesterase activity
has related synonym: cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP) activity
has related synonym: nucleoside 3',5'-cyclic phosphate diesterase activity
has related synonym: nucleoside-3',5-monophosphate phosphodiesterase activity
has related synonym: PDE

3',5'-cyclic-AMP phosphodiesterase activity
type: Class
subclass of: 3',5'-cyclic-nucleotide phosphodiesterase activity
IAO_0000115: Catalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+.
has exact synonym: 3',5' cAMP-specific phosphodiesterase activity
has exact synonym: 3',5'-cAMP-specific phosphodiesterase activity
has exact synonym: 3',5'-cyclic-AMP-specific phosphodiesterase activity
has exact synonym: adenosine 3',5'-cyclophosphate-specific phosphodiesterase activity
has exact synonym: cAMP-specific phosphodiesterase activity
has exact synonym: cyclic AMP-specific phosphodiesterase activity

calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
type: Class
subclass of: 3',5'-cyclic-AMP phosphodiesterase activity
subclass of: GO_0047555
IAO_0000115: Catalysis of the reactions: 3',5'-cyclic AMP + H2O = AMP + H+ and 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin.
has related synonym: calmodulin-activated cyclic-nucleotide dual specificity phosphodiesterase activity
has related synonym: calmodulin-dependent cyclic-nucleotide phosphodiesterase activity

cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
type: Class
subclass of: 3',5'-cyclic-nucleotide phosphodiesterase activity
IAO_0000115: Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP.

cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
type: Class
subclass of: 3',5'-cyclic-nucleotide phosphodiesterase activity
IAO_0000115: Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP.

photoreceptor cyclic-nucleotide phosphodiesterase activity
type: Class
subclass of: 3',5'-cyclic-nucleotide phosphodiesterase activity
IAO_0000115: Catalysis of the reaction: nucleoside cyclic phosphate + H2O = nucleoside phosphate. This reaction is the hydrolysis of bonds in a cyclic nucleotide.

cystathionine beta-lyase activity
type: Class
subclass of: GO_0016846
IAO_0000115: Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate.
has related synonym: beta C-S lyase activity
has related synonym: beta-cystathionase activity
has related synonym: cystathionine L-homocysteine-lyase (deaminating)
has related synonym: cystine lyase activity
has related synonym: L-cystathionine L-homocysteine-lyase (deaminating; pyruvate-forming)
has related synonym: L-cystathionine L-homocysteine-lyase (deaminating)
replaces: GO_0008799

cystathionine beta-synthase activity
type: Class
subclass of: GO_0016836
IAO_0000115: Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O.
has related synonym: beta-thionase activity
has related synonym: L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)
has related synonym: L-serine hydro-lyase (adding homocysteine)
has related synonym: methylcysteine synthase activity
has related synonym: serine sulfhydrase activity
has related synonym: serine sulfhydrylase activity

cystathionine gamma-lyase activity
type: Class
subclass of: GO_0016846
IAO_0000115: Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+.
has related synonym: gamma-cystathionase activity
has related synonym: homoserine deaminase activity
has related synonym: homoserine deaminase-cystathionase activity
has related synonym: homoserine dehydratase activity
has related synonym: L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)
has related synonym: L-cystathionine cysteine-lyase (deaminating)
replaces: GO_0016225

cysteine synthase activity
type: Class
subclass of: GO_0016765
subclass of: part-of-parent-19344
IAO_0000115: Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate.
has related synonym: 3-O-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity
has related synonym: acetylserine sulfhydrylase activity
has related synonym: cysteine synthetase activity
has related synonym: O(3)-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide) activity
has related synonym: O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity
has related synonym: O3-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide)
has related synonym: O-acetyl-L-serine sulfhydrylase activity
has related synonym: O-acetyl-L-serine sulfohydrolase activity
has related synonym: O-acetylserine (thiol)-lyase A activity
has related synonym: O-acetylserine (thiol)-lyase activity
has related synonym: O-acetylserine sulfhydrylase activity
has related synonym: OAS sulfhydrylase activity

L-seryl-tRNASec selenium transferase activity
type: Class
subclass of: GO_0016785
subclass of: GO_0140101
IAO_0000115: Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate.
has related synonym: cysteinyl-tRNA(Sec)-selenium transferase activity
has related synonym: cysteinyl-tRNA(Sel)-selenium transferase activity
has exact synonym: cysteinyl-tRNA(Ser) selenium transferase activity
has related synonym: cysteinyl-tRNASec-selenium transferase activity
has related synonym: cysteinyl-tRNASel-selenium transferase activity
has related synonym: L-selenocysteinyl-tRNA(Sec) synthase activity
has related synonym: L-selenocysteinyl-tRNA(Sel) synthase activity
has related synonym: L-selenocysteinyl-tRNASec synthase activity
has related synonym: L-selenocysteinyl-tRNASel synthase activity
has exact synonym: L-seryl-tRNA(Ser) selenium transferase activity
has exact synonym: selenocysteine synthase activity
has exact synonym: selenocysteinyl-tRNA(Ser) synthase activity
has related synonym: selenophosphate:L-seryl-tRNASec selenium transferase activity

cytidine deaminase activity
type: Class
subclass of: GO_0016814
subclass of: GO_0019239
subclass of: part-of-parent-9972
IAO_0000115: Catalysis of the reaction: cytidine + H2O = uridine + NH3.
has related synonym: cytidine aminohydrolase activity
has related synonym: cytosine nucleoside deaminase activity

cytidylate kinase activity
type: Class
subclass of: GO_0050145
IAO_0000115: Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP.
has related synonym: ATP:CMP phosphotransferase activity
has related synonym: ATP:UMP-CMP phosphotransferase activity
has related synonym: CMP kinase activity
has related synonym: CTP:CMP phosphotransferase activity
has related synonym: cytidine monophosphate kinase activity
has related synonym: dCMP kinase activity
has related synonym: deoxycytidine monophosphokinase activity
has related synonym: deoxycytidylate kinase activity
has related synonym: pyrimidine nucleoside monophosphate kinase activity
has related synonym: UMP-CMP kinase activity

cytochrome-b5 reductase activity, acting on NAD(P)H
type: Class
subclass of: GO_0016653
IAO_0000115: Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5).
has related synonym: cytochrome b5 reductase activity
has related synonym: dihydronicotinamide adenine dinucleotide-cytochrome b5 reductase activity
has related synonym: NADH:ferricytochrome-b5 oxidoreductase activity
has related synonym: NADH 5alpha-reductase activity
has related synonym: NADH-cytochrome b5 reductase activity
has related synonym: NADH-cytochrome-b5 reductase activity
has related synonym: NADH-ferricytochrome b5 oxidoreductase activity
has related synonym: reduced nicotinamide adeninedinucleotide-cytochrome b5 reductase activity

cytochrome-c oxidase activity
type: Class
subclass of: GO_0009055
subclass of: GO_0015078
subclass of: GO_0015453
subclass of: GO_0016675
subclass of: GO_0022853
IAO_0000115: Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
has related synonym: aa3-type cytochrome c oxidase
has related synonym: ba3-type cytochrome c oxidase
has related synonym: caa3-type cytochrome c oxidase
has related synonym: cbb3-type cytochrome c oxidase
has related synonym: complex IV (mitochondrial electron transport) activity
has related synonym: cytochrome a3 activity
has related synonym: cytochrome aa3 activity
has exact synonym: cytochrome c oxidase activity
has related synonym: cytochrome oxidase activity
has related synonym: indophenolase
has related synonym: indophenol oxidase
has related synonym: Warburg's respiratory enzyme activity

cytochrome-c peroxidase activity
type: Class
subclass of: peroxidase activity
IAO_0000115: Catalysis of the reaction: 2 ferrocytochrome c + hydrogen peroxide = 2 ferricytochrome c + 2 H2O.
has related synonym: apocytochrome c peroxidase activity
has related synonym: cytochrome c-551 peroxidase activity
has related synonym: cytochrome c-H2O oxidoreductase activity
has related synonym: cytochrome c peroxidase activity
has related synonym: cytochrome peroxidase activity
has related synonym: ferrocytochrome-c:hydrogen-peroxide oxidoreductase activity
has related synonym: mesocytochrome c peroxidase azide
has related synonym: mesocytochrome c peroxidase cyanate
has related synonym: mesocytochrome c peroxidase cyanide

cytosine deaminase activity
type: Class
subclass of: GO_0016814
subclass of: GO_0019239
IAO_0000115: Catalysis of the reaction: cytosine + H2O = uracil + NH3.
has related synonym: cytosine aminohydrolase activity
has related synonym: isocytosine deaminase activity

dCMP deaminase activity
type: Class
subclass of: GO_0016814
subclass of: GO_0019239
IAO_0000115: Catalysis of the reaction: dCMP + H2O = dUMP + NH3.
has related synonym: dCMP aminohydrolase activity
has related synonym: deoxy-CMP-deaminase activity
has related synonym: deoxycytidine-5'-monophosphate aminohydrolase activity
has related synonym: deoxycytidine-5'-phosphate deaminase activity
has related synonym: deoxycytidine monophosphate deaminase activity
has related synonym: deoxycytidylate aminohydrolase activity
has related synonym: deoxycytidylate deaminase activity

glycogen debranching enzyme activity
type: Class
subclass of: catalytic activity
subclass of: part-of-parent-5977
IAO_0000115: Catalysis of the cleavage of branch points in branched glycogen polymers.

4-alpha-glucanotransferase activity
type: Class
subclass of: GO_0016758
IAO_0000115: Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan.
has related synonym: 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase activity
has related synonym: amylomaltase activity
has related synonym: debranching enzyme maltodextrin glycosyltransferase activity
has related synonym: D-enzyme activity
has related synonym: dextrin glycosyltransferase activity
has related synonym: dextrin transglycosylase activity
has related synonym: disproportionating enzyme activity
has related synonym: oligo-1,4-1,4-glucantransferase activity

amylo-alpha-1,6-glucosidase activity
type: Class
subclass of: GO_0090599
IAO_0000115: Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present.
has exact synonym: amylo-1,6-glucosidase activity
has related synonym: amylopectin 1,6-glucosidase activity
has related synonym: dextrin-1,6-glucosidase activity
has related synonym: dextrin 6-alpha-D-glucosidase activity
has related synonym: glycogen phosphorylase-limit dextrin alpha-1,6-glucohydrolase activity

deoxyadenosine kinase activity
type: Class
subclass of: GO_0019136
subclass of: part-of-parent-6170
IAO_0000115: Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H(+).
has related synonym: ATP:deoxyadenosine 5'-phosphotransferase activity
has related synonym: deoxyadenosine kinase (phosphorylating)
has related synonym: purine-deoxyribonucleoside kinase activity

deoxycytidine kinase activity
type: Class
subclass of: GO_0019136
IAO_0000115: Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP.
has related synonym: 2'-deoxycytidine kinase activity
has related synonym: arabinofuranosylcytosine kinase activity
has related synonym: Ara-C kinase activity
has related synonym: deoxycytidine-cytidine kinase activity
has related synonym: deoxycytidine kinase (phosphorylating)
has related synonym: NTP:deoxycytidine 5'-phosphotransferase activity

deoxyguanosine kinase activity
type: Class
subclass of: GO_0019136
IAO_0000115: Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H(+).
has related synonym: (dihydroxypropoxymethyl)guanine kinase activity
has related synonym: 2'-deoxyguanosine kinase activity
has related synonym: ATP:deoxyguanosine 5'-phosphotransferase activity
has related synonym: deoxyguanosine kinase (phosphorylating)
has related synonym: NTP-deoxyguanosine 5'-phosphotransferase activity

deoxyribose-phosphate aldolase activity
type: Class
subclass of: GO_0016832
IAO_0000115: Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.
has related synonym: 2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase (D-glyceraldehyde-3-phosphate-forming)
has related synonym: 2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase activity
has related synonym: 2-deoxyribose-5-phosphate aldolase activity
has related synonym: deoxyriboaldolase activity
has related synonym: deoxyribose-5-phosphate aldolase activity
has related synonym: phosphodeoxyriboaldolase activity

dephospho-CoA kinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016773
IAO_0000115: Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H(+).
has related synonym: 3'-dephospho-CoA kinase activity
has related synonym: ATP:dephospho-CoA 3'-phosphotransferase activity
has related synonym: dephosphocoenzyme A kinase (phosphorylating)
has related synonym: dephosphocoenzyme A kinase activity

dethiobiotin synthase activity
type: Class
subclass of: GO_0016882
IAO_0000115: Catalysis of the reaction: 7,8-diaminononanoate + ATP + CO(2) = ADP + dethiobiotin + 4 H(+) + phosphate.
has related synonym: 7,8-diaminononanoate:carbon-dioxide cyclo-ligase (ADP-forming)
has related synonym: desthiobiotin synthase activity
has related synonym: DTB synthetase activity

diacylglycerol cholinephosphotransferase activity
type: Class
subclass of: GO_0017169
subclass of: part-of-parent-6657
IAO_0000115: Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine.
has related synonym: 1-alkyl-2-acetylglycerol cholinephosphotransferase activity
has related synonym: 1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase activity
has related synonym: 1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase activity
has related synonym: alkylacylglycerol cholinephosphotransferase activity
has related synonym: alkylacylglycerol choline phosphotransferase activity
has related synonym: CDP-choline:1,2-diacylglycerol cholinephosphotransferase activity
has related synonym: CDP-choline diglyceride phosphotransferase activity
has related synonym: cholinephosphotransferase activity
has related synonym: CPT
has related synonym: cytidine diphosphocholine glyceride transferase activity
has related synonym: cytidine diphosphorylcholine diglyceride transferase activity
has related synonym: diacylglycerol choline phosphotransferase activity
has related synonym: phosphocholine diacylglyceroltransferase activity
has related synonym: phosphorylcholine--glyceride transferase activity
has related synonym: sn-1,2-diacylglycerol cholinephosphotransferase activity

diacylglycerol kinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016773
IAO_0000115: Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate.
has related synonym: 1,2-diacylglycerol kinase (phosphorylating)
has related synonym: 1,2-diacylglycerol kinase activity
has related synonym: arachidonoyl-specific diacylglycerol kinase activity
has related synonym: ATP:1,2-diacylglycerol 3-phosphotransferase activity
has related synonym: ATP:diacylglycerol phosphotransferase activity
has related synonym: CTP:diacylglycerol kinase activity
has related synonym: DGK activity
has related synonym: DG kinase activity
has related synonym: diacylglycerol:ATP kinase activity
has related synonym: diglyceride kinase activity
has related synonym: sn-1,2-diacylglycerol kinase activity

diacylglycerol O-acyltransferase activity
type: Class
subclass of: GO_0016411
IAO_0000115: Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.
has related synonym: 1,2-diacylglycerol acyltransferase activity
has related synonym: acyl-CoA:1,2-diacylglycerol O-acyltransferase activity
has related synonym: diacylglycerol acyltransferase activity
has related synonym: diglyceride acyltransferase activity
has related synonym: diglyceride O-acyltransferase activity
has related synonym: palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity

diamine N-acetyltransferase activity
type: Class
subclass of: GO_0008080
IAO_0000115: Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine.
has related synonym: acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase activity
has related synonym: acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase activity
has exact synonym: diamine acetyltransferase activity
has related synonym: putrescine (diamine)-acetylating enzyme activity
has related synonym: putrescine acetylase activity
has related synonym: putrescine acetyltransferase activity
has related synonym: putrescine N-acetyltransferase activity
has related synonym: spermidine/spermine N1-acetyltransferase activity
has related synonym: spermidine acetyltransferase activity
has related synonym: spermidine N(1)-acetyltransferase activity
has related synonym: spermidine N1-acetyltransferase activity
has related synonym: spermine acetyltransferase
has related synonym: spermine N(1)-acetyltransferase
has related synonym: spermine N-acetyltransferase

dihydrofolate reductase activity
type: Class
subclass of: GO_0016646
IAO_0000115: Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+.
has related synonym: 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity
has related synonym: 7,8-dihydrofolate reductase activity
has related synonym: DHFR
has related synonym: dihydrofolate reductase:thymidylate synthase activity
has exact synonym: dihydrofolate reduction
has related synonym: dihydrofolic acid reductase activity
has related synonym: dihydrofolic reductase activity
has related synonym: folic acid reductase activity
has related synonym: folic reductase activity
has related synonym: NADPH-dihydrofolate reductase activity
has related synonym: pteridine reductase:dihydrofolate reductase activity
has related synonym: tetrahydrofolate dehydrogenase activity
has related synonym: thymidylate synthetase-dihydrofolate reductase activity

dihydrolipoamide branched chain acyltransferase activity
type: Class
subclass of: GO_0030523
IAO_0000115: Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide, where the acyl group is a branched chain.
has exact synonym: dihydrolipoamide branched chain transacylase activity

dihydrolipoyl dehydrogenase activity
type: Class
subclass of: GO_0016668
IAO_0000115: Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+.
has related synonym: dehydrolipoate dehydrogenase activity
has related synonym: diaphorase activity
has related synonym: dihydrolipoamide:NAD+ oxidoreductase
has related synonym: dihydrolipoamide dehydrogenase activity
has related synonym: dihydrolipoamide reduction
has related synonym: dihydrolipoic dehydrogenase activity
has related synonym: dihydrolipoylprotein reduction
has related synonym: dihydrothioctic dehydrogenase activity
has related synonym: E3 component of alpha-ketoacid dehydrogenase complexes activity
has related synonym: glycine-cleavage system L-protein activity
has related synonym: LDP-Glc activity
has related synonym: LDP-Val activity
has related synonym: lipoamide dehydrogenase (NADH) activity
has related synonym: lipoamide oxidoreductase (NADH) activity
has related synonym: lipoamide reductase (NADH) activity
has related synonym: lipoamide reductase activity
has related synonym: lipoate dehydrogenase activity
has related synonym: lipoic acid dehydrogenase activity
has related synonym: lipoyl dehydrogenase activity
has related synonym: L-protein activity
has related synonym: protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase
has related synonym: protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase

dihydrolipoyllysine-residue succinyltransferase activity
type: Class
subclass of: GO_0016751
subclass of: GO_0140096
IAO_0000115: Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide.
has exact synonym: dihydrolipoamide S-succinyltransferase activity
has related synonym: dihydrolipoamide succinyltransferase activity
has related synonym: dihydrolipoic transsuccinylase activity
has related synonym: dihydrolipolyl transsuccinylase activity
has related synonym: dihydrolipoyl transsuccinylase activity
has related synonym: enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase activity
has related synonym: lipoate succinyltransferase (Escherichia coli) activity
has related synonym: lipoate succinyltransferase activity
has related synonym: lipoic transsuccinylase activity
has related synonym: lipoyl transsuccinylase activity
has related synonym: succinyl-CoA:dihydrolipoamide S-succinyltransferase activity
has related synonym: succinyl-CoA:dihydrolipoate S-succinyltransferase activity
has related synonym: succinyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-succinyltransferase activity
has related synonym: succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase activity

dihydroneopterin aldolase activity
type: Class
subclass of: GO_0016832
IAO_0000115: Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde.
has related synonym: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-forming)
has related synonym: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase activity

dihydroorotase activity
type: Class
subclass of: GO_0016812
IAO_0000115: Catalysis of the reaction: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate + H(+).
has related synonym: (S)-dihydroorotate amidohydrolase activity
has related synonym: carbamoylaspartic dehydrase activity
has related synonym: DHOase activity
has related synonym: dihydroorotate hydrolase activity

dihydroorotate dehydrogenase activity
type: Class
subclass of: GO_0016635
IAO_0000115: Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate.
has related synonym: (DHO) dehydrogenase activity
has exact synonym: (S)-dihydroorotate:quinone oxidoreductase activity
has related synonym: DHOdehase activity
has related synonym: dihydoorotic acid dehydrogenase activity
has related synonym: dihydroorotate:ubiquinone oxidoreductase activity

dihydropterin deaminase activity
type: Class
subclass of: GO_0019239
IAO_0000115: Catalysis of the reaction: 7,8-dihydropterin + H2O = 7,8-dihydrolumazine + NH3.

dihydropterin oxidase activity
type: Class
subclass of: GO_0016647
IAO_0000115: Catalysis of the reaction: a 7,8-dihydropteridine + O2 = a pterin + hydrogen peroxide.

6,7-dihydropteridine reductase activity
type: Class
subclass of: GO_0016646
IAO_0000115: Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine.
has related synonym: 5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase activity
has related synonym: 5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase activity
has related synonym: 6,7-dihydropteridine:NAD(P)H oxidoreductase activity
has related synonym: DHPR activity
has related synonym: dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase activity
has related synonym: dihydropteridine reductase (NADH) activity
has exact synonym: dihydropteridine reductase activity
has related synonym: dihydropteridine reduction
has related synonym: NAD(P)H(2):6,7-dihydropteridine oxidoreductase activity
has related synonym: NAD(P)H2:6,7-dihydropteridine oxidoreductase activity
has related synonym: NADH-dihydropteridine reductase activity
has related synonym: NADPH-dihydropteridine reductase activity
has related synonym: NADPH-specific dihydropteridine reductase activity

dihydropteroate synthase activity
type: Class
subclass of: GO_0016765
IAO_0000115: Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.
has related synonym: (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity
has related synonym: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity
has related synonym: 7,8-dihydropteroate synthase activity
has related synonym: 7,8-dihydropteroate synthetase activity
has related synonym: 7,8-dihydropteroic acid synthetase activity
has related synonym: DHPS activity
has related synonym: dihydropteroate diphosphorylase activity
has related synonym: dihydropteroate pyrophosphorylase activity
has related synonym: dihydropteroate synthetase activity
has related synonym: dihydropteroic synthetase activity

dihydropyrimidinase activity
type: Class
subclass of: GO_0016812
IAO_0000115: Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate.
has related synonym: 5,6-dihydropyrimidine amidohydrolase activity
has related synonym: D-hydantoinase activity
has related synonym: hydantoinase activity
has related synonym: hydantoin peptidase activity
has related synonym: hydropyrimidine hydrase activity
has related synonym: pyrimidine hydrase activity

dihydroorotate oxidase activity
type: Class
subclass of: dihydroorotate dehydrogenase activity
subclass of: GO_0016634
IAO_0000115: Catalysis of the reaction: (S)-dihydroorotate + O(2) = H(2)O(2) + orotate.
has related synonym: (S)-dihydroorotate:oxygen oxidoreductase activity
has related synonym: 4,5-L-dihydroorotate:oxygen oxidoreductase activity

dihydropyrimidine dehydrogenase (NAD+) activity
type: Class
subclass of: GO_0016628
IAO_0000115: Catalysis of the reaction: a 5,6-dihydropyrimidine (5,6-dihydrouracil or 5,6-dihydrothymine) + NAD+ = a pyrimidine (uracil or thymine) + NADH + H+.
has related synonym: 5,6-dihydrouracil:NAD+ oxidoreductase activity
has related synonym: dihydrothymine dehydrogenase (NAD+) activity
has related synonym: dihydrouracil dehydrogenase (NAD+) activity
has related synonym: pyrimidine reductase activity
has related synonym: thymine reductase activity
has related synonym: uracil reductase activity

dihydroxy-acid dehydratase activity
type: Class
subclass of: GO_0016836
IAO_0000115: Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.
has related synonym: 2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming)
has related synonym: 2,3-dihydroxy-acid hydro-lyase activity
has related synonym: 2,3-dihydroxyisovalerate dehydratase activity
has related synonym: acetohydroxyacid dehydratase activity
has related synonym: alpha,beta-dihydroxyacid dehydratase activity
has related synonym: alpha,beta-dihydroxyisovalerate dehydratase activity
has related synonym: DHAD
has related synonym: dihydroxy acid dehydrase activity

dimethylallyltranstransferase activity
type: Class
subclass of: prenyltransferase activity
IAO_0000115: Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
has related synonym: (2E,6E)-farnesyl diphosphate synthetase activity
has related synonym: dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase activity
has exact synonym: dimethylallyltransferase activity
has related synonym: diprenyltransferase activity
has related synonym: DMAPP:IPP-dimethylallyltransferase activity
has exact synonym: geranyl diphosphate synthase
has related synonym: geranyl-diphosphate synthase activity
has related synonym: geranyl pyrophosphate synthase activity
has related synonym: geranyl pyrophosphate synthetase activity
has related synonym: trans-farnesyl pyrophosphate synthetase activity

dimethylnitrosamine demethylase activity
type: Class
subclass of: GO_0032451
IAO_0000115: Catalysis of the removal of a methyl group from N-nitrosodimethylamine.
has exact synonym: N-nitrosodimethylamine demethylase activity

diphosphomevalonate decarboxylase activity
type: Class
subclass of: GO_0016831
IAO_0000115: Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO(2) + H(+) + isopentenyl diphosphate + phosphate.
has related synonym: 5-pyrophosphomevalonate decarboxylase activity
has related synonym: ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP; isopentenyl-diphosphate-forming)
has related synonym: ATP:(R)-5-diphosphomevalonate carboxy-lyase (dehydrating)
has related synonym: mevalonate 5-diphosphate decarboxylase activity
has related synonym: mevalonate-5-pyrophosphate decarboxylase activity
has related synonym: mevalonate diphosphate decarboxylase activity
has related synonym: mevalonate pyrophosphate decarboxylase activity
has related synonym: pyrophosphomevalonate decarboxylase activity
has related synonym: pyrophosphomevalonic acid decarboxylase activity

diphthine synthase activity
type: Class
subclass of: GO_0008757
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine.
has related synonym: diphthine methyltransferase activity
has related synonym: S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine methyltransferase activity
has related synonym: S-adenosyl-L-methionine:elongation factor 2 methyltransferase activity

delta(3)-delta(2)-enoyl-CoA isomerase activity
type: Class
subclass of: GO_0016863
IAO_0000115: Catalysis of the reactions: a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA or a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA.
has related synonym: 3,2-trans-enoyl-CoA isomerase activity
has related synonym: acetylene-allene isomerase activity
has related synonym: delta(3),delta(2)-enoyl-CoA isomerase activity
has related synonym: delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase activity
has related synonym: delta3,delta2-enoyl-CoA isomerase activity
has exact synonym: delta3-cis-delta2-trans-enoyl-CoA isomerase
has exact synonym: delta3-delta2 enoyl-CoA isomerase activity
has related synonym: dodecenoyl-CoA (3Z)-(2E)-isomerase activity
has related synonym: dodecenoyl-CoA delta3-cis-delta2-trans-isomerase activity
has related synonym: dodecenoyl-CoA delta-isomerase activity
has related synonym: dodecenoyl-CoA D-isomerase activity
has related synonym: dodecenoyl-CoA isomerase activity
replaces: GO_0008461

dolichyl-phosphate alpha-N-acetylglucosaminyltransferase activity
type: Class
subclass of: GO_0008375
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate.
has related synonym: dolichyl phosphate acetylglucosaminyltransferase activity
has related synonym: dolichyl-phosphate acetylglucosaminyltransferase activity
has related synonym: dolichyl phosphate N-acetylglucosaminyltransferase activity
has related synonym: dolichyl-phosphate N-acetylglucosaminyltransferase activity
has related synonym: UDP-N-acetyl-D-glucosamine:dolichyl-phosphate alpha-N-acetyl-D-glucosaminyltransferase activity
has related synonym: UDP-N-acetylglucosamine-dolichol phosphate N-acetylglucosaminyltransferase activity
has related synonym: uridine diphosphoacetylglucosamine-dolichol phosphate acetylglucosaminyltransferase activity
replaces: GO_0004101

dopachrome isomerase activity
type: Class
subclass of: GO_0016863
IAO_0000115: Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.
has related synonym: DCF activity
has related synonym: DCT activity
has related synonym: dopachrome conversion activity
has related synonym: dopachrome conversion factor activity
has related synonym: dopachrome Delta(7),Delta(2)-isomerase activity
has related synonym: dopachrome delta7,Delta2-isomerase activity
has exact synonym: dopachrome delta-isomerase activity
has related synonym: dopachrome keto-enol isomerase activity
has related synonym: dopachrome oxidoreductase activity
has related synonym: dopachrome-rearranging enzyme
has related synonym: dopachrome rearranging enzyme activity
has related synonym: dopachrome tautomerase activity
has related synonym: L-dopachrome isomerase activity
has related synonym: L-dopachrome keto-enol isomerase activity
has related synonym: L-dopachrome-methyl ester tautomerase activity
has related synonym: TRP-1
has related synonym: TRP2
has related synonym: TRP-2
has related synonym: TRP activity
has related synonym: tryosinase-related protein-2
has related synonym: tyrosinase-related protein 2 activity
replaces: GO_0048059

dolichol kinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016773
IAO_0000115: Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate.
has related synonym: CTP:dolichol O-phosphotransferase activity
has related synonym: dolichol phosphokinase activity

dolichyl-phosphate-mannose-protein mannosyltransferase activity
type: Class
subclass of: mannosyltransferase activity
subclass of: GO_0140096
subclass of: part-of-parent-35269
IAO_0000115: Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.
has related synonym: dolichol phosphomannose-protein mannosyltransferase activity
has related synonym: dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase activity
has exact synonym: dolichyl-phosphate-mannose-protein O-mannosyltransferase activity
has related synonym: O-glycoside mannosyltransferase
has related synonym: protein O-D-mannosyltransferase activity
has exact synonym: protein O-mannosyltransferase activity

dUTP diphosphatase activity
type: Class
subclass of: GO_0047429
IAO_0000115: Catalysis of the reaction: dUTP + H2O = dUMP + H+ + diphosphate.
has related synonym: deoxyuridine-triphosphatase activity
has related synonym: desoxyuridine 5'-triphosphatase activity
has related synonym: desoxyuridine 5'-triphosphate nucleotidohydrolase activity
has related synonym: dUTPase activity
has related synonym: dUTP nucleotidohydrolase activity
has exact synonym: dUTP pyrophosphatase activity

obsolete deoxyhypusine synthase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.

obsolete ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

ecdysone O-acyltransferase activity
type: Class
subclass of: GO_0008374
IAO_0000115: Catalysis of the reaction: Ecdysone + palmitoyl-CoA = CoA + ecdysone palmitate.
has related synonym: acyl-CoA:ecdysone acyltransferase activity
has related synonym: fatty acyl-CoA:ecdysone acyltransferase activity
has related synonym: palmitoyl-CoA:ecdysone palmitoyltransferase activity

electron-transferring-flavoprotein dehydrogenase activity
type: Class
subclass of: GO_0009055
subclass of: GO_0016649
subclass of: part-of-parent-22904
IAO_0000115: Catalysis of the reaction: a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + H+ + oxidized [electron-transfer flavoprotein].
has related synonym: electron transfer flavoprotein dehydrogenase activity
has related synonym: electron transfer flavoprotein Q oxidoreductase activity
has related synonym: electron transfer flavoprotein reductase activity
has related synonym: electron transfer flavoprotein-ubiquinone oxidoreductase activity
has related synonym: electron-transferring-flavoprotein:ubiquinone oxidoreductase activity
has related synonym: ETF:ubiquinone oxidoreductase activity
has related synonym: ETF dehydrogenase activity
has related synonym: ETF-QO activity
has related synonym: ETF-ubiquinone oxidoreductase activity

endopeptidase activity
type: Class
subclass of: GO_0008233
IAO_0000115: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
has related synonym: elastase activity
has related synonym: endoprotease activity
has related synonym: proteasome endopeptidase activity
has related synonym: proteinase
replaces: GO_0016809

ATP-dependent peptidase activity
type: Class
subclass of: GO_0008233
subclass of: GO_0140657
IAO_0000115: Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis.
has related synonym: ATP-dependent proteolysis
replaces: GO_0004280

aminopeptidase activity
type: Class
subclass of: GO_0008238
IAO_0000115: Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain.

obsolete leucyl aminopeptidase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Xbb may be Pro.

obsolete membrane alanyl aminopeptidase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.

carboxypeptidase activity
type: Class
subclass of: GO_0008238
IAO_0000115: Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain.

metallocarboxypeptidase activity
type: Class
subclass of: carboxypeptidase activity
subclass of: GO_0008235
IAO_0000115: Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

obsolete carboxypeptidase A activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: peptidyl-L-amino acid + H2O = peptide + L-amino acid. Little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
replaces: GO_0008731

obsolete carboxypeptidase E activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+ and inhibited by 1,10-phenanthroline and other chelating agents.

obsolete lysine carboxypeptidase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Release of a C-terminal basic amino acid, preferentially lysine; inactivates bradykinin and anaphylatoxins in blood plasma.

serine-type carboxypeptidase activity
type: Class
subclass of: carboxypeptidase activity
subclass of: GO_0070008
IAO_0000115: Catalysis of the hydrolysis of a single C-terminal amino acid residue from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
has exact synonym: serine carboxypeptidase activity

obsolete carboxypeptidase C activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity.

obsolete carboxypeptidase D activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the preferential release of a C-terminal arginine or lysine residue. Function is inhibited by diisopropyl fluorophosphate and sensitive to thiol-blocking reagents.

obsolete serine-type Pro-X carboxypeptidase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a serine-type peptidase mechanism to release a C-terminal amino acid.
replaces: GO_0008323

obsolete tubulinyl-Tyr carboxypeptidase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the cleavage of the Glu-Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr.

aspartic-type endopeptidase activity
type: Class
subclass of: endopeptidase activity
subclass of: GO_0070001
IAO_0000115: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
has related synonym: aspartate protease activity
has exact synonym: aspartic endopeptidase activity
has related synonym: aspartic protease activity
has related synonym: aspartyl protease activity
has related synonym: carboxyl protease activity

obsolete barrierpepsin activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the selected cleavage of the Leu6-Lys7 bond in the pheromone alpha-mating factor.

obsolete cathepsin D activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His5 bond in the B chain of insulin.

obsolete cathepsin E activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin D, but slightly broader specificity.

obsolete pepsin A activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-Val2, Gln4-His5, Glu13-Ala14, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Gly23-Phe24, Phe24-Phe25 and Phe25-Tyr26 bonds in the B chain of insulin.

obsolete renin activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the cleavage of Leu-Xaa bond in angiotensinogen to generate angiotensin I.

obsolete saccharopepsin activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin more restricted than pepsin A; does not cleave Phe1-Val2, Gln4-His5 or Gly23-Phe24.

cysteine-type endopeptidase activity
type: Class
subclass of: endopeptidase activity
subclass of: GO_0008234
IAO_0000115: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
has related synonym: caspase activity
has related synonym: lysosomal cysteine-type endopeptidase
has related synonym: metacaspase activity
has exact synonym: thiol endopeptidase activity

calcium-dependent cysteine-type endopeptidase activity
type: Class
subclass of: cysteine-type endopeptidase activity
IAO_0000115: Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
has related synonym: calpain activity

obsolete signaling (initiator) caspase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete caspase-1 activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the release of interleukin 1-beta by specific cleavage of Asp116-Ala117 and Asp27-Gly28 bonds in precursor. Enzymes with this function can also hydrolyze the terminal bond in the small-molecule substrate, Ac-Tyr-Val-Ala-Asp-NHMec.

obsolete caspase-2 activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete caspase-4 activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete caspase-5 activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete caspase-8 activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete caspase-10 activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete effector caspase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete caspase-3 activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the cleavage at the terminal bond of the motif: Asp-Xaa-Xaa-Asp-Xaa. Enzymes with this function are members of the peptidase family C14 and they appear to function in the inactivation of proteins involved in cellular repair and homeostasis during the effector stage of apoptosis.

obsolete caspase-6 activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete caspase-7 activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete caspase-9 activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete lysosomal cysteine-type endopeptidase
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete cathepsin B activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of peptide bonds with a broad specificity. Preferentially cleaves the terminal bond of -Arg-Arg-Xaa motifs in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.

obsolete dipeptidyl-peptidase I activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the release of an N-terminal dipeptide, Xaa-Xbb from Xaa-Xbb-Xcc, except when Xaa is Arg or Lys, or Xbb or Xcc is Pro.

obsolete cathepsin H activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of peptide bonds, acting as an aminopeptidase (notably, cleaving Arg-Xaa bonds) as well as an endopeptidase.

obsolete cathepsin K activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Has a broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.

obsolete cathepsin L activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.

obsolete cathepsin S activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin L, but with much less activity on the terminal bond of Z-Phe-Arg-NHMec, and more activity on the terminal bond of Z-Val-Val-Arg-Xaa compounds.

obsolete pyroglutamyl-peptidase I activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: pyroglutamyl-peptide + H2O = pyroglutamate + peptide.

obsolete ubiquitin thiolesterase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol.
replaces: GO_0008577

metalloendopeptidase activity
type: Class
subclass of: endopeptidase activity
subclass of: GO_0008237
IAO_0000115: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
has related synonym: metalloendoprotease activity
has related synonym: metalloendoproteinase activity

obsolete Gly-X carboxypeptidase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: peptidyl-Gly-Xaa + H2O = peptidyl-Gly + Xaa.

obsolete gelatinase A activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln at the Gly-Ile bond.

obsolete gelatinase B activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the cleavage of gelatin types I and V and collagen types IV and V.

obsolete glutamyl aminopeptidase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide.

obsolete insulysin activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the degradation of insulin, glucagon and other polypeptides. No action on proteins.

obsolete interstitial collagenase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.

obsolete macrophage elastase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at Ala14-Leu15 and Tyr16-Leu17 in the B chain of insulin.

obsolete matrilysin activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the cleavage of Ala14-Leu15 and Tyr16-Leu17 in B chain of insulin. No action on collagen types I, II, IV and V. Cleaves gelatin chain alpha-2(I) > alpha-1(I).

obsolete membrane dipeptidase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of dipeptides.

obsolete meprin A activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.

obsolete methionyl aminopeptidase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.

obsolete mitochondrial processing peptidase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.

obsolete alpha-mitochondrial processing peptidase
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete beta-mitochondrial processing peptidase
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete mitochondrial intermediate peptidase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the release of an N-terminal octapeptide as second stage of processing of some proteins imported in the mitochondrion.

obsolete mitochondrial inner membrane peptidase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the maturation of mitochondrial precursor proteins delivered to the intermembrane space.

obsolete neprilysin activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage at the amino group of hydrophobic residues in insulin, casein, hemoglobin, and a number of other proteins and polypeptides.

obsolete peptidyl-dipeptidase A activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the release of a C-terminal dipeptide, Xaa-Xbb from oligopeptide-Xaa-Xbb, when Xaa is not Pro, and Xbb is neither Asp nor Glu. Converts angiotensin I to angiotensin II.

obsolete saccharolysin activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the cleavage of Pro-Phe and Ala-Ala bonds.

obsolete stromelysin 1 activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage where P1', P2' and P3' are hydrophobic residues.

obsolete stromelysin 3 activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Was not defined before being made obsolete.

obsolete aminopeptidase I activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates.

obsolete X-Pro dipeptidase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.

serine-type endopeptidase activity
type: Class
subclass of: endopeptidase activity
subclass of: GO_0008236
IAO_0000115: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
has related synonym: blood coagulation factor activity
has related synonym: serine elastase activity

obsolete gamma-renin activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the cleavage of the Leu-Leu bond in synthetic tetradecapeptide renin substrate, producing angiotensin I, but not active on natural angiotensinogen. Also hydrolyzes BZ-Arg-para-nitroanilide.

obsolete acylaminoacyl-peptidase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: acylaminoacyl-peptide + H2O = acylamino acid + peptide.

obsolete vacuolar carboxypeptidase Y
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity.

obsolete cathepsin G activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to chymotrypsin C.

obsolete cerevisin activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, and of BZ-Arg-OET > Ac-Tyr-OET. Does not hydrolyze peptide amides.

obsolete chymotrypsin activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of Tyr-Xaa > Trp-Xaa > Phe-Xaa > Leu-Xaa.

obsolete dipeptidyl-peptidase IV activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the release of an N-terminal dipeptide, by the hydrolysis of the Xbb-Xcc bond in Xaa-Xbb-Xcc, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline.

obsolete enteropeptidase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the selective cleavage of Lys6-Ile7 bond in trypsinogen.

obsolete furin activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the release of mature proteins from their proproteins by cleavage of the terminal bond of Arg-Xaa-Yaa-Arg-Z motifs where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.

obsolete granzyme A activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: Arg-Xaa > Lys-Xaa > Phe-Xaa in small molecule substrates.

obsolete granzyme B activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of Asp-Xaa > Asn-Xaa > Met-Xaa, Ser-Xaa.

obsolete pancreatic elastase II activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of Leu-Xaa, Met-Xaa and Phe-Xaa. Hydrolyzes elastin.

obsolete plasmin activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of Lys-Xaa > Arg-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products.

obsolete acrosin activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa > Lys-Xaa.

obsolete proprotein convertase 1 activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the release of protein hormones, neuropeptides and renin from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond.

obsolete proprotein convertase 2 activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the release of protein hormones and neuropeptides from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond.

obsolete prolyl oligopeptidase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of Pro-Xaa > Ala-Xaa in oligopeptides.

obsolete subtilase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Was not defined before being made obsolete.

obsolete kexin activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the cleavage of the Arg-Xaa bond in Lys-Arg-Xaa and Arg-Arg-Xaa to process Yeast alpha-factor pheromone and killer toxin precursors.

obsolete subtilisin activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.

obsolete tissue kallikrein activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-Xaa or Leu-Xaa. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-Xaa bonds.
replaces: GO_0004279

obsolete tripeptidyl-peptidase II activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide at neutral pH.

obsolete trypsin activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa.

threonine-type endopeptidase activity
type: Class
subclass of: endopeptidase activity
subclass of: GO_0070003
IAO_0000115: Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.
has related synonym: 26S protease
has related synonym: alkaline protease
has related synonym: ingensin
has related synonym: large multicatalytic protease
has related synonym: lens neutral proteinase
has related synonym: MCP
has related synonym: multicatalytic endopeptidase complex
has related synonym: multicatalytic proteinase
has related synonym: multicatalytic proteinase (complex)
has related synonym: prosome
has related synonym: proteasome endopeptidase complex
has exact synonym: threonine endopeptidase activity
has related synonym: tricorn protease
has related synonym: tricorn proteinase

obsolete proteasome endopeptidase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the cleavage at peptide bonds with very broad specificity.

enoyl-CoA hydratase activity
type: Class
subclass of: GO_0016836
IAO_0000115: Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O.
has related synonym: (3S)-3-hydroxyacyl-CoA hydro-lyase activity
has related synonym: 2-enoyl-CoA hydratase activity
has related synonym: 2-octenoyl coenzyme A hydrase activity
has related synonym: acyl coenzyme A hydrase activity
has related synonym: beta-hydroxyacid dehydrase activity
has related synonym: beta-hydroxyacyl-CoA dehydrase activity
has related synonym: crotonyl hydrase activity
has related synonym: D-3-hydroxyacyl-CoA dehydratase
has related synonym: ECH
has related synonym: enol-CoA hydratase activity
has related synonym: enoyl coenzyme A hydrase (D)
has related synonym: enoyl coenzyme A hydrase (L)
has related synonym: enoyl coenzyme A hydratase activity
has related synonym: enoyl hydrase activity
has related synonym: hydratase, enoyl coenzyme A
has exact synonym: short-chain enoyl-CoA hydratase activity
has related synonym: short chain enoyl coenzyme A hydratase activity
has related synonym: trans-2-enoyl-CoA hydratase activity
has related synonym: unsaturated acyl-CoA hydratase activity
replaces: GO_0016510

epoxide hydrolase activity
type: Class
subclass of: GO_0016803
IAO_0000115: Catalysis of the reaction: an epoxide + H2O = a glycol.
has related synonym: arene-oxide hydratase activity
has related synonym: aryl epoxide hydrase activity
has related synonym: cytosolic epoxide hydrolase activity
has related synonym: epoxide hydrase activity
has related synonym: epoxide hydratase activity
has related synonym: sEH
has related synonym: soluble epoxide hydrolase activity
has related synonym: trans-stilbene oxide hydrolase activity

estradiol 17-beta-dehydrogenase activity
type: Class
subclass of: GO_0033764
IAO_0000115: Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+.
has related synonym: 17beta,20alpha-hydroxysteroid dehydrogenase activity
has related synonym: 17beta-estradiol dehydrogenase activity
has related synonym: 17-beta-estradiol dehydrogenase activity
has related synonym: 17beta-HSD
has related synonym: 17-beta-HSD activity
has related synonym: 17beta-hydroxysteroid dehydrogenase activity
has related synonym: 17-beta-hydroxysteroid dehydrogenase activity
has related synonym: 20alpha-hydroxysteroid dehydrogenase
has related synonym: estradiol-17beta:NAD(P)+ 17-oxidoreductase activity
has related synonym: estradiol 17beta-dehydrogenase activity
has related synonym: estradiol dehydrogenase activity
has related synonym: estrogen 17-oxidoreductase activity

estrone sulfotransferase activity
type: Class
subclass of: GO_0008146
IAO_0000115: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate.
has related synonym: 3'-phosphoadenylyl-sulfate:estrone 3-sulfotransferase activity
has related synonym: 3'-phosphoadenylylsulfate:oestrone sulfotransferase activity
has related synonym: 3'-phosphoadenylyl sulfate-estrone 3-sulfotransferase activity
has related synonym: estrogen sulfotransferase
has related synonym: estrogen sulphotransferase activity
has exact synonym: estrone sulphotransferase activity
has related synonym: oestrogen sulphotransferase activity

ethanolamine kinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016773
IAO_0000115: Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H(+) + phosphoethanolamine.
has related synonym: ATP:ethanolamine O-phosphotransferase activity
has related synonym: ethanolamine kinase (phosphorylating)
has related synonym: ethanolamine phosphokinase activity

ethanolamine-phosphate cytidylyltransferase activity
type: Class
subclass of: GO_0070567
IAO_0000115: Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine.
has exact synonym: CTP:ethanolamine-phosphate cytidylyltransferase activity
has related synonym: CTP:phosphoethanolamine cytidylyltransferase activity
has related synonym: CTP-phosphoethanolamine cytidylyltransferase activity
has related synonym: ET
has related synonym: ethanolamine phosphate cytidylyltransferase activity
has exact synonym: phosphoethanolamine cytidylyltransferase activity
has related synonym: phosphorylethanolamine transferase activity

ethanolaminephosphotransferase activity
type: Class
subclass of: GO_0017169
IAO_0000115: Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine.
has related synonym: CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase activity
has related synonym: CDPethanolamine diglyceride phosphotransferase activity
has related synonym: diacylglycerol ethanolaminephosphotransferase activity
has related synonym: EPT
has related synonym: phosphorylethanolamine-glyceride transferase activity

exo-alpha-sialidase activity
type: Class
subclass of: GO_0016997
IAO_0000115: Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
has related synonym: acetylneuraminidase activity
has related synonym: acetylneuraminyl hydrolase activity
has related synonym: alpha-neuraminidase activity
has related synonym: N-acylneuraminate glycohydrolase activity
has related synonym: neuraminidase activity
has related synonym: sialidase activity

exopolyphosphatase activity
type: Class
subclass of: GO_0016462
IAO_0000115: Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate.
has related synonym: acid phosphoanhydride phosphohydrolase activity
has related synonym: exopolypase activity
has related synonym: Gra-Pase activity
has related synonym: metaphosphatase activity
has related synonym: polyphosphate phosphohydrolase activity

farnesyl-diphosphate farnesyltransferase activity
type: Class
subclass of: farnesyltranstransferase activity
IAO_0000115: Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate.
has related synonym: farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase activity
has related synonym: presqualene-diphosphate synthase activity
has related synonym: presqualene synthase activity

farnesyltranstransferase activity
type: Class
subclass of: prenyltransferase activity
IAO_0000115: Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.
has related synonym: farnesyltransferase activity
has related synonym: geranylgeranyl-diphosphate synthase activity
has related synonym: geranylgeranyl-PP synthetase activity
has related synonym: geranylgeranyl pyrophosphate synthase activity
has related synonym: geranylgeranyl pyrophosphate synthetase activity
has related synonym: trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity

fatty acid synthase activity
type: Class
subclass of: GO_0016747
IAO_0000115: Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
has related synonym: acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)
has exact synonym: fatty-acid synthase activity

[acyl-carrier-protein] S-acetyltransferase activity
type: Class
subclass of: fatty acid synthase activity
subclass of: GO_0016418
IAO_0000115: Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein].
has exact synonym: [acyl-carrier protein] S-acetyltransferase activity
has related synonym: ACAT activity
has related synonym: acetyl-CoA:acyl-carrier-protein S-acetyltransferase activity
has related synonym: acetyl coenzyme A-acyl-carrier-protein transacylase activity
has related synonym: ACPacetyltransferase activity
has related synonym: ACP acetyltransferase activity
has exact synonym: ACP S-acetyltransferase activity
has related synonym: acyl-carrier-proteinacetyltransferase activity
has related synonym: acyl-carrier-protein acetyltransferase activity
has related synonym: acyl-carrier-protein S-acetyltransferase activity

[acyl-carrier-protein] S-malonyltransferase activity
type: Class
subclass of: fatty acid synthase activity
subclass of: GO_0016419
IAO_0000115: Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein].
has exact synonym: [acyl-carrier protein] S-malonyltransferase activity
has exact synonym: ACP S-malonyltransferase activity
has related synonym: acyl carrier proteinmalonyltransferase activity
has related synonym: acyl carrier protein malonyltransferase activity
has related synonym: acyl-carrier-protein S-malonyltransferase activity
has related synonym: FabD
has related synonym: malonyl-CoA:AcpM transacylase activity
has related synonym: malonyl-CoA:ACP transacylase activity
has related synonym: malonyl-CoA:acyl-carrier-protein S-malonyltransferase activity
has related synonym: malonyl-CoA:acyl carrier protein transacylase activity
has related synonym: malonyl-CoA-acyl carrier protein transacylase activity
has related synonym: malonyl coenzyme A-acyl carrier protein transacylase activity
has related synonym: malonyl transacylase activity
has related synonym: malonyl transferase activity
has related synonym: MAT
has related synonym: MCAT activity

3-oxoacyl-[acyl-carrier-protein] synthase activity
type: Class
subclass of: fatty acid synthase activity
IAO_0000115: Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein].
has related synonym: 3-ketoacyl-acyl carrier protein synthase activity
has related synonym: 3-oxoacyl:ACP synthase I
has exact synonym: 3-oxoacyl-[acyl-carrier protein] synthase activity
has exact synonym: 3-oxoacyl-ACP synthase activity
has related synonym: 3-oxoacyl-acyl-carrier-protein synthase activity
has related synonym: 3-oxoacyl-acyl carrier protein synthase I activity
has related synonym: acyl-acyl-carrier-protein:malonyl-acyl-carrier-protein C-acyltransferase (decarboxylating)
has related synonym: acyl-malonyl(acyl-carrier-protein)-condensing enzyme activity
has related synonym: acyl-malonyl acyl carrier protein-condensing enzyme activity
has related synonym: beta-ketoacyl-[acyl carrier protein] synthase activity
has related synonym: beta-ketoacyl-ACP synthase I activity
has related synonym: beta-ketoacyl-ACP synthase II activity
has related synonym: beta-ketoacyl-ACP synthetase activity
has related synonym: beta-ketoacyl acyl carrier protein synthase activity
has related synonym: beta-ketoacyl-acyl carrier protein synthase activity
has related synonym: beta-ketoacyl-acyl-carrier-protein synthase I
has related synonym: beta-ketoacyl-acyl-carrier-protein synthase II activity
has related synonym: beta-ketoacyl-acyl carrier protein synthetase activity
has related synonym: beta-ketoacylsynthase activity
has related synonym: beta-ketoacyl synthetase activity
has related synonym: condensing enzyme activity
has related synonym: fatty acid condensing enzyme activity
has related synonym: KASI
has related synonym: KAS I activity
has related synonym: KASII
has related synonym: KAS II
has exact synonym: ketoacyl-ACP synthase activity
replaces: GO_0033817

3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
type: Class
subclass of: fatty acid synthase activity
subclass of: GO_0016616
IAO_0000115: Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+.
has related synonym: (3R)-3-hydroxyacyl-acyl-carrier-protein:NADP+ oxidoreductase activity
has related synonym: 3-ketoacyl acyl carrier protein reductase activity
has exact synonym: 3-oxoacyl-[acyl-carrier protein] reductase activity
has related synonym: 3-oxoacyl-ACPreductase activity
has exact synonym: 3-oxoacyl-ACP reductase activity
has related synonym: 3-oxoacyl-acyl-carrier-protein reductase activity
has related synonym: beta-ketoacyl-ACP reductase activity
has related synonym: beta-ketoacyl acyl carrier protein (ACP) reductase activity
has related synonym: beta-ketoacyl-acyl-carrier protein(ACP) reductase activity
has related synonym: beta-ketoacyl-acyl carrier protein reductase activity
has related synonym: beta-ketoacyl reductase activity
has related synonym: beta-ketoacyl thioester reductase activity
has related synonym: NADPH-specific 3-oxoacyl-acylcarrier proteinreductase activity

3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
type: Class
subclass of: fatty acid synthase activity
subclass of: GO_0019171
IAO_0000115: Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O.
has related synonym: (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase activity
has exact synonym: (3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase (hexadec-2-enoyl-acyl-carrier protein-forming)
has exact synonym: (3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase activity
has exact synonym: 3-hydroxypalmitoyl-[acyl-carrier protein] dehydratase activity
has exact synonym: 3-hydroxypalmitoyl-ACP dehydratase activity
has exact synonym: 3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity
has related synonym: beta-hydroxypalmitoyl-acyl carrier protein dehydrase activity
has related synonym: beta-hydroxypalmitoyl thioester dehydratase activity
has related synonym: beta-hydroxypalmityl-ACP dehydrase activity
has related synonym: D-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
has related synonym: D-3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity

enoyl-[acyl-carrier-protein] reductase (NADH) activity
type: Class
subclass of: fatty acid synthase activity
subclass of: GO_0016628
IAO_0000115: Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+.
has related synonym: acyl-acyl-carrier-protein:NAD+ oxidoreductase
has related synonym: enoyl-[acyl-carrier protein] reductase (NADH) activity
has related synonym: enoyl-ACP reductase (NADH) activity
has related synonym: enoyl-acyl-carrier-protein reductase (NADH)
has related synonym: NADH-enoyl acyl carrier protein reductase activity
has related synonym: NADH-specific enoyl-ACP reductase activity

enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity
type: Class
subclass of: fatty acid synthase activity
subclass of: GO_0016628
IAO_0000115: Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+.
has related synonym: acyl-acyl-carrier-protein:NADP+ oxidoreductase (B-specific)
has exact synonym: enoyl-[acyl-carrier protein] reductase (NADPH, B-specific) activity
has exact synonym: enoyl-ACP reductase (NADPH, B-specific) activity
has related synonym: enoyl-acyl-carrier-protein reductase (NADPH, B-specific)
has related synonym: enoyl-acyl-carrier-protein reductase (NADPH2, B-specific)
has related synonym: enoyl acyl-carrier-protein reductase activity
has related synonym: NADPH 2-enoyl Co A reductase activity
has related synonym: reductase, enoyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide phosphate)

oleoyl-[acyl-carrier-protein] hydrolase activity
type: Class
subclass of: GO_0016297
IAO_0000115: Catalysis of the reaction: oleoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + oleate.
has exact synonym: oleoyl-[acyl-carrier protein] hydrolase activity
has exact synonym: oleoyl-ACP hydrolase activity
has related synonym: oleoyl-ACP thioesterase activity
has related synonym: oleoyl-acyl-carrier-protein hydrolase
has related synonym: oleoyl-acyl carrier protein thioesterase activity

fatty-acyl-CoA synthase activity
type: Class
subclass of: GO_0016408
IAO_0000115: Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+.
has related synonym: acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl- reducing)
has exact synonym: fatty acyl CoA synthase activity
has related synonym: yeast fatty acid synthase activity

ferroxidase activity
type: Class
subclass of: GO_0016724
IAO_0000115: Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.
has related synonym: caeruloplasmin
has related synonym: ceruloplasmin
has related synonym: Fe(II):oxygen oxidoreductase activity
has related synonym: ferro:O2 oxidoreductase activity
has related synonym: ferroxidase, iron II:oxygen oxidoreductase activity
has related synonym: ferroxidase I
has related synonym: HEPH
has related synonym: hephaestin
has related synonym: iron(II): oxygen oxidoreductase activity
has related synonym: multicopper ferroxidase iron transport mediator activity

obsolete multicopper ferroxidase iron transport mediator activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

ferredoxin-NADP+ reductase activity
type: Class
subclass of: GO_0008937
IAO_0000115: Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+.
has related synonym: ferredoxin:NADP+ oxidoreductase activity
has related synonym: ferredoxin-NADP oxidoreductase activity
has related synonym: ferredoxin-NADP-oxidoreductase activity
has exact synonym: ferredoxin-NADP reductase activity
has related synonym: ferredoxin-nicotinamide-adenine dinucleotide phosphate (oxidized) reductase activity
has related synonym: ferredoxin-nicotinamide adenine dinucleotide phosphate reductase activity
has related synonym: ferredoxin-TPN reductase activity
has related synonym: NADP:ferredoxin oxidoreductase activity
has related synonym: NADPH:ferredoxin oxidoreductase activity
has related synonym: reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase activity
has related synonym: TPNH-ferredoxin reductase activity

ferrochelatase activity
type: Class
subclass of: GO_0016829
IAO_0000115: Catalysis of the reaction: heme B (protoheme) + H+ = Fe(2+) + protoporphyrin IX.
has exact synonym: ferro-protoporphyrin chelatase activity
has related synonym: heme synthase activity
has related synonym: heme synthetase activity
has related synonym: iron chelatase activity
has exact synonym: protoheme ferro-lyase (protoporphyrin-forming)
has exact synonym: protoheme ferrolyase activity
has exact synonym: protoheme ferro-lyase activity

tetrahydrofolylpolyglutamate synthase activity
type: Class
subclass of: GO_0016881
subclass of: part-of-parent-46901
IAO_0000115: Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1).
has related synonym: folate polyglutamate synthetase activity
has related synonym: folylpoly(gamma-glutamate) synthase activity
has related synonym: folylpoly-gamma-glutamate synthase activity
has related synonym: folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity
has exact synonym: folylpolyglutamate synthase activity
has related synonym: folylpolyglutamate synthetase activity
has related synonym: folylpolyglutamyl synthetase activity
has related synonym: formyltetrahydropteroyldiglutamate synthetase activity
has related synonym: FPGS activity
has related synonym: N(10)-formyltetrahydropteroyldiglutamate synthetase activity
has related synonym: N10-formyltetrahydropteroyldiglutamate synthetase activity
has related synonym: tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity
has related synonym: tetrahydrofolate synthase activity
has related synonym: tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming)
has related synonym: tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming)

obsolete formaldehyde dehydrogenase (glutathione) activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: formaldehyde + glutathione + NAD+ = S-formylglutathione + NADH + H+.

formamidase activity
type: Class
subclass of: GO_0016811
IAO_0000115: Catalysis of the reaction: formamide + H(2)O = formate + NH(4)(+).
has related synonym: formamide amidohydrolase activity
has exact synonym: formamide hydrolase activity
replaces: GO_0034566

formate-tetrahydrofolate ligase activity
type: Class
subclass of: GO_0016879
IAO_0000115: Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.
has related synonym: 10-formyltetrahydrofolate synthetase activity
has exact synonym: 10-formyl-THF synthetase activity
has related synonym: formate:tetrahydrofolate ligase (ADP-forming)
has related synonym: formyltetrahydrofolate synthetase activity
has related synonym: tetrahydrofolate formylase activity
has related synonym: tetrahydrofolic formylase activity

fructose-2,6-bisphosphate 2-phosphatase activity
type: Class
subclass of: GO_0050308
IAO_0000115: Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate.
has related synonym: beta-D-fructose-2,6-bisphosphate 2-phosphohydrolase activity
has related synonym: D-fructose-2,6-bisphosphate 2-phosphohydrolase activity
has related synonym: fructose-2,6-bisphosphatase activity
replaces: GO_0004330

fructose-bisphosphate aldolase activity
type: Class
subclass of: GO_0016832
IAO_0000115: Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate.
has related synonym: 1,6-diphosphofructose aldolase activity
has related synonym: aldolase activity
has related synonym: D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)
has related synonym: D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase activity
has related synonym: diphosphofructose aldolase activity
has related synonym: fructoaldolase activity
has related synonym: fructose-1,6-bisphosphate triosephosphate-lyase activity
has related synonym: fructose 1,6-diphosphate aldolase activity
has related synonym: fructose 1-monophosphate aldolase activity
has related synonym: fructose 1-phosphate aldolase activity
has related synonym: fructose diphosphate aldolase activity
has related synonym: ketose 1-phosphate aldolase activity
has related synonym: phosphofructoaldolase activity
has related synonym: SMALDO
has related synonym: zymohexase activity

fumarate hydratase activity
type: Class
subclass of: GO_0016836
IAO_0000115: Catalysis of the reaction: (S)-malate = fumarate + H(2)O.
has related synonym: (S)-malate hydro-lyase (fumarate-forming)
has related synonym: (S)-malate hydro-lyase activity
has related synonym: fumarase activity
has related synonym: L-malate hydro-lyase activity

fumarylacetoacetase activity
type: Class
subclass of: GO_0016823
IAO_0000115: Catalysis of the reaction: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate + H(+).
has related synonym: 4-fumarylacetoacetate fumarylhydrolase activity
has related synonym: beta-diketonase activity
has related synonym: fumarylacetoacetate hydrolase activity

galactokinase activity
type: Class
subclass of: GO_0016773
subclass of: GO_0019200
IAO_0000115: Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H(+).
has related synonym: ATP:D-galactose 1-phosphotransferase activity
has related synonym: ATP:D-galactose-1-phosphotransferase activity
has related synonym: galactokinase (phosphorylating)

galactosylceramidase activity
type: Class
subclass of: hydrolase activity, hydrolyzing O-glycosyl compounds
IAO_0000115: Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine.
has related synonym: beta-galactocerebrosidase activity
has related synonym: beta-galactosylceramidase activity
has related synonym: ceramide galactosidase activity
has related synonym: cerebroside beta-galactosidase activity
has related synonym: cerebroside galactosidase activity
has related synonym: D-galactosyl-N-acylsphingosine galactohydrolase activity
has related synonym: galactocerebrosidase activity
has related synonym: galactocerebroside-beta-D-galactosidase activity
has related synonym: galactocerebroside beta-galactosidase activity
has related synonym: galactocerebroside galactosidase activity
has related synonym: galactosylceramidase I
has related synonym: galactosylceramide beta-galactosidase activity
has related synonym: galactosylcerebrosidase activity
has related synonym: galcerase activity
has related synonym: lactosylceramidase activity
has related synonym: lactosylceramidase I

geranyltranstransferase activity
type: Class
subclass of: prenyltransferase activity
IAO_0000115: Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate.
has exact synonym: farnesyl-diphosphate synthase activity
has related synonym: farnesyl diphosphate synthetase activity
has related synonym: farnesylpyrophosphate synthetase activity
has exact synonym: farnesyl pyrophosphate synthetase activity
has related synonym: FPP synthetase activity
has related synonym: geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase activity
has related synonym: geranyltransferase activity
has related synonym: geranyl transferase I

glucan exo-1,3-beta-glucosidase activity
type: Class
subclass of: GO_0008422
IAO_0000115: Catalysis of the successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.
has related synonym: 1,3-beta-glucan glucohydrolase activity
has related synonym: beta-1,3-glucan exo-hydrolase activity
has related synonym: exo (1->3)-beta-glucanase activity
has related synonym: exo-1,3-beta-D-glucanase activity
has related synonym: exo-1,3-beta-glucanase activity
has related synonym: exo-1,3-beta-glucosidase activity
has related synonym: exo-beta-(1->3)-D-glucanase activity
has related synonym: exo-beta-(1->3)-glucanohydrolase activity
has related synonym: exo-beta-1,3-D-glucanase activity
has related synonym: exo-beta-1,3-glucanase activity
has related synonym: glucan 1,3-beta-glucosidase activity

glucan 1,4-alpha-glucosidase activity
type: Class
subclass of: GO_0015926
IAO_0000115: Catalysis of the hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.
has related synonym: 1,4-alpha-D-glucan glucohydrolase activity
has related synonym: amyloglucosidase activity
has related synonym: exo-1,4-alpha-glucosidase activity
has related synonym: gamma-1,4-glucan glucohydrolase activity
has related synonym: gamma-amylase activity
has exact synonym: glucoamylase activity
has related synonym: glucose amylase activity
has related synonym: lysosomal alpha-glucosidase activity

glucokinase activity
type: Class
subclass of: hexokinase activity
subclass of: part-of-parent-51156
IAO_0000115: Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate.
has related synonym: ATP:D-glucose 6-phosphotransferase activity
has related synonym: glucokinase (phosphorylating)
has related synonym: glucose kinase activity

gluconolactonase activity
type: Class
subclass of: GO_0052689
IAO_0000115: Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate.
has related synonym: aldonolactonase activity
has related synonym: D-glucono-1,5-lactone lactonohydrolase activity
has related synonym: glucono-delta-lactonase activity
has related synonym: gulonolactonase activity
has related synonym: lactonase activity

glucosamine-6-phosphate deaminase activity
type: Class
subclass of: GO_0016861
subclass of: GO_0019239
IAO_0000115: Catalysis of the reaction: D-glucosamine 6-phosphate + H(2)O = beta-D-fructose 6-phosphate + NH(4)(+).
has related synonym: 2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)
has related synonym: aminodeoxyglucosephosphate isomerase activity
has related synonym: GlcN6P deaminase activity
has related synonym: glucosamine-6-phosphate isomerase activity
has related synonym: glucosamine phosphate deaminase activity
has related synonym: glucosaminephosphate isomerase
has related synonym: phosphoglucosamine isomerase activity
has related synonym: phosphoglucosaminisomerase activity

glucosamine 6-phosphate N-acetyltransferase activity
type: Class
subclass of: GO_0008080
IAO_0000115: Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+).
has related synonym: acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase activity
has related synonym: aminodeoxyglucosephosphate acetyltransferase activity
has related synonym: D-glucosamine-6-P N-acetyltransferase activity
has related synonym: glucosamine 6-phosphate acetylase activity
has related synonym: glucosamine-6-phosphate acetylase activity
has exact synonym: glucosamine-phosphate N-acetyltransferase activity
has related synonym: N-acetylglucosamine-6-phosphate synthase activity
has related synonym: phosphoglucosamine acetylase activity
has related synonym: phosphoglucosamine N-acetylase activity
has related synonym: phosphoglucosamine transacetylase activity

glucose dehydrogenase activity
type: Class
subclass of: GO_0016614
IAO_0000115: Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor.
has exact synonym: glucose dehydrogenase (acceptor) activity
has exact synonym: soluble glucose dehydrogenase
replaces: GO_0008708

glucose-6-phosphate dehydrogenase activity
type: Class
subclass of: GO_0016616
IAO_0000115: Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+.
has related synonym: 6-phosphoglucose dehydrogenas
has exact synonym: 6-phosphoglucose dehydrogenase activity
has related synonym: D-glucose-6-phosphate:NADP+ 1-oxidoreductase activity
has exact synonym: D-glucose 6-phosphate dehydrogenase activity
has related synonym: Entner-doudoroff enzyme
has related synonym: G6PD activity
has exact synonym: G6PDH
has related synonym: GDH
has exact synonym: glucose-6-phosphate 1-dehydrogenase activity
has exact synonym: glucose 6-phosphate dehydrogenase (NADP) activity
has exact synonym: NADP-dependent glucose 6-phosphate dehydrogenase activity
has exact synonym: NADP-glucose-6-phosphate dehydrogenase activity
has related synonym: Zwischenferment

glucose-6-phosphatase activity
type: Class
subclass of: GO_0050309
IAO_0000115: Catalysis of the reaction: D-glucopyranose 6-phosphate + H2O = D-glucose + phosphate. D-glucopyranose is also known as D-glucose 6-phosphate.
has related synonym: D-glucose-6-phosphate phosphohydrolase activity
has related synonym: glucose 6-phosphate phosphatase activity

glucose-6-phosphate isomerase activity
type: Class
subclass of: GO_0016861
IAO_0000115: Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate.
has related synonym: D-glucose-6-phosphate aldose-ketose-isomerase activity
has related synonym: D-glucose-6-phosphate ketol-isomerase activity
has related synonym: glucose phosphate isomerase activity
has related synonym: hexose monophosphate isomerase activity
has related synonym: hexosephosphate isomerase activity
has related synonym: hexose phosphate isomerase activity
has related synonym: oxoisomerase activity
has related synonym: phosphoglucoisomerase activity
has related synonym: phosphoglucose isomerase activity
has related synonym: phosphohexoisomerase activity
has related synonym: phosphohexomutase activity
has related synonym: phosphohexose isomerase activity
has related synonym: phosphosaccharomutase activity

glucosylceramidase activity
type: Class
subclass of: hydrolase activity, hydrolyzing O-glycosyl compounds
IAO_0000115: Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.
has related synonym: acid beta-glucosidase activity
has related synonym: beta-D-glucocerebrosidase activity
has related synonym: beta-glucocerebrosidase activity
has related synonym: beta-glucosylceramidase activity
has related synonym: ceramide glucosidase activity
has related synonym: D-glucosyl-N-acylsphingosine glucohydrolase activity
has related synonym: GlcCer-beta-glucosidase activity
has related synonym: glucocerebrosidase activity
has related synonym: glucosphingosine glucosylhydrolase activity
has related synonym: glucosylcerebrosidase activity
has related synonym: glucosylsphingosine beta-D-glucosidase activity
has related synonym: glucosylsphingosine beta-glucosidase activity
has related synonym: psychosine hydrolase activity

glutamate 5-kinase activity
type: Class
subclass of: GO_0016774
subclass of: GO_0019202
IAO_0000115: Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H(+).
has related synonym: ATP:gamma-L-glutamate phosphotransferase activity
has related synonym: ATP:L-glutamate 5-phosphotransferase activity
has related synonym: ATP-L-glutamate 5-phosphotransferase activity
has related synonym: gamma-glutamate kinase activity
has related synonym: gamma-glutamyl kinase activity
has related synonym: glutamate kinase activity

glutamate-5-semialdehyde dehydrogenase activity
type: Class
subclass of: GO_0016620
IAO_0000115: Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH.
has related synonym: beta-glutamylphosphate reductase activity
has related synonym: gamma-glutamylphosphate reductase activity
has related synonym: gamma-glutamyl phosphate reductase activity
has related synonym: glutamate-gamma-semialdehyde dehydrogenase activity
has exact synonym: glutamate-phosphate reductase activity
has related synonym: glutamate semialdehyde dehydrogenase activity
has related synonym: glutamyl-gamma-semialdehyde dehydrogenase activity
has exact synonym: glutamylphosphate reductase activity
has related synonym: L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)
replaces: GO_0001513

glutamate decarboxylase activity
type: Class
subclass of: GO_0016831
IAO_0000115: Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2.
has related synonym: aspartic alpha-decarboxylase
has related synonym: cysteic acid decarboxylase activity
has related synonym: gamma-glutamate decarboxylase activity
has related synonym: L-aspartate-alpha-decarboxylase activity
has related synonym: L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)
has related synonym: L-glutamate 1-carboxy-lyase activity
has related synonym: L-glutamate alpha-decarboxylase activity
has related synonym: L-glutamic acid decarboxylase activity
has related synonym: L-glutamic decarboxylase activity

glutamate dehydrogenase (NAD+) activity
type: Class
subclass of: glutamate dehydrogenase [NAD(P)+] activity
IAO_0000115: Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+.
has related synonym: glutamate dehydrogenase (NAD)
has related synonym: glutamate oxidoreductase activity
has related synonym: glutamic acid dehydrogenase
has related synonym: glutamic dehydrogenase activity
has related synonym: L-glutamate:NAD+ oxidoreductase (deaminating)
has related synonym: L-glutamate dehydrogenase
has related synonym: NAD:glutamate oxidoreductase activity
has related synonym: NAD-dependent glutamate dehydrogenase activity
has related synonym: NAD-dependent glutamic dehydrogenase activity
has related synonym: NAD-glutamate dehydrogenase activity
has related synonym: NADH-linked glutamate dehydrogenase activity
has related synonym: NAD-linked glutamate dehydrogenase activity
has related synonym: NAD-linked glutamic dehydrogenase activity
has related synonym: NAD-specific glutamate dehydrogenase activity
has related synonym: NAD-specific glutamic dehydrogenase activity

glutamate dehydrogenase [NAD(P)+] activity
type: Class
subclass of: GO_0016639
IAO_0000115: Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+.
has related synonym: glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)
has related synonym: glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)
has related synonym: glutamic dehydrogenase activity
has related synonym: L-glutamate:NAD(P)+ oxidoreductase (deaminating)

glutamate dehydrogenase (NADP+) activity
type: Class
subclass of: glutamate dehydrogenase [NAD(P)+] activity
IAO_0000115: Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+.
has related synonym: dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))
has related synonym: glutamic acid dehydrogenase
has related synonym: glutamic dehydrogenase activity
has related synonym: L-glutamate:NADP+ oxidoreductase (deaminating)
has related synonym: L-glutamate dehydrogenase
has related synonym: L-glutamic acid dehydrogenase activity
has related synonym: NAD(P)-glutamate dehydrogenase activity
has related synonym: NAD(P)H-dependent glutamate dehydrogenase activity

glutamate synthase (NADPH) activity
type: Class
subclass of: GO_0045181
IAO_0000115: Catalysis of the reaction: 2 L-glutamate + NADP(+) = 2-oxoglutarate + L-glutamine + H(+) + NADPH. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+.
has related synonym: glutamate (reduced nicotinamide adenine dinucleotide phosphate) synthase activity
has related synonym: glutamate synthetase (NADP) activity
has related synonym: glutamine amide-2-oxoglutarate aminotransferase (oxidoreductase, NADP) activity
has related synonym: glutamine-ketoglutaric aminotransferase activity
has related synonym: GOGAT activity
has related synonym: L-glutamate:NADP+ oxidoreductase (transaminating)
has related synonym: L-glutamate synthase activity
has related synonym: L-glutamate synthetase activity
has related synonym: L-glutamine:2-oxoglutarate aminotransferase, NADPH oxidizing activity
has related synonym: NADPH-dependent glutamate synthase activity
has related synonym: NADPH-glutamate synthase activity
has exact synonym: NADPH GOGAT
has related synonym: NADPH-linked glutamate synthase

glutamate-ammonia ligase activity
type: Class
subclass of: GO_0016211
IAO_0000115: Catalysis of the reaction: L-glutamate + ATP + NH(3) = L-glutamine + ADP + 2 H(+) + phosphate.
has exact synonym: glutamine synthetase activity
has related synonym: glutamylhydroxamic synthetase activity
has related synonym: L-glutamate:ammonia ligase (ADP-forming)
has related synonym: L-glutamine synthetase activity

glutamate-cysteine ligase activity
type: Class
subclass of: GO_0016881
IAO_0000115: Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate.
has related synonym: gamma-glutamylcysteine synthetase activity
has related synonym: gamma-glutamylcysteinyl synthetase activity
has related synonym: gamma-glutamyl-L-cysteine synthetase activity
has related synonym: L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity

glutamate N-acetyltransferase activity
type: Class
subclass of: GO_0008080
IAO_0000115: Catalysis of the reaction: N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine.
has related synonym: 2-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity
has related synonym: acetylglutamate-acetylornithine transacetylase activity
has related synonym: acetylglutamate synthetase activity
has related synonym: acetylglutamic-acetylornithine transacetylase activity
has related synonym: acetylglutamic synthetase activity
has related synonym: acetylornithinase activity
has related synonym: acetylornithine glutamate acetyltransferase activity
has related synonym: alpha-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity
has related synonym: glutamate acetyltransferase activity
has related synonym: N2-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity
has related synonym: N-acetylglutamate synthase activity
has related synonym: N-acetylglutamate synthetase activity
has related synonym: N-acetyl-L-glutamate synthetase activity
has related synonym: ornithine acetyltransferase activity
has related synonym: ornithine transacetylase activity

glutaminase activity
type: Class
subclass of: GO_0016811
IAO_0000115: Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3.
has related synonym: glutaminase I
has related synonym: glutamine aminohydrolase activity
has related synonym: L-glutaminase activity
has related synonym: L-glutamine amidohydrolase activity

glutamine-fructose-6-phosphate transaminase (isomerizing) activity
type: Class
subclass of: GO_0070548
IAO_0000115: Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate.
has related synonym: D-fructose-6-phosphate amidotransferase activity
has related synonym: GlcN6P synthase activity
has exact synonym: glucosamine-6-phosphate isomerase (glutamine-forming) activity
has related synonym: glucosamine 6-phosphate synthase activity
has related synonym: glucosamine-6-phosphate synthase activity
has related synonym: glucosamine--fructose-6-phosphate aminotransferase (isomerizing) activity
has related synonym: glucosaminephosphate isomerase
has related synonym: hexosephosphate aminotransferase activity
has related synonym: L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
has related synonym: L-glutamine-D-fructose-6-phosphate amidotransferase activity

glutaryl-CoA dehydrogenase activity
type: Class
subclass of: acyl-CoA dehydrogenase activity
IAO_0000115: 3-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein].
has related synonym: glutaryl coenzyme A dehydrogenase activity

glutathione-disulfide reductase (NADPH) activity
type: Class
subclass of: GO_0015038
subclass of: GO_0016209
subclass of: GO_0047134
IAO_0000115: Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+.
has related synonym: glutathione:NADP+ oxidoreductase activity
has exact synonym: glutathione-disulfide reductase activity
has exact synonym: glutathione-disulphide reductase activity
has exact synonym: glutathione reductase activity
has related synonym: glutathione S-reductase activity
has related synonym: GSH reductase activity
has related synonym: GSSG reductase activity
has related synonym: NADPH:oxidized-glutathione oxidoreductase activity
has related synonym: NADPH-glutathione reductase activity
has related synonym: NADPH-GSSG reductase activity
has related synonym: oxidized glutathione reduction

glutathione synthase activity
type: Class
subclass of: GO_0016881
subclass of: part-of-parent-6750
IAO_0000115: Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate.
has related synonym: gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
has related synonym: glutathione synthetase activity
has related synonym: GSH synthetase activity

glutathione transferase activity
type: Class
subclass of: GO_0016765
IAO_0000115: Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
has exact synonym: glutathione conjugation reaction
has related synonym: glutathione S-alkyltransferase activity
has related synonym: glutathione S-alkyl transferase activity
has related synonym: glutathione S-aralkyltransferase activity
has related synonym: glutathione S-aryltransferase activity
has related synonym: glutathione S-transferase activity
has related synonym: RX:glutathione R-transferase activity
has related synonym: S-(hydroxyalkyl)glutathione lyase activity

glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
type: Class
subclass of: GO_0043891
IAO_0000115: Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+.
has related synonym: 3-phosphoglyceraldehyde dehydrogenase activity
has related synonym: dehydrogenase, glyceraldehyde phosphate
has related synonym: D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)
has related synonym: GAPDH activity
has related synonym: glyceraldehyde-3-P-dehydrogenase activity
has related synonym: glyceraldehyde phosphate dehydrogenase (NAD)
has related synonym: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase activity
has related synonym: NAD-dependent glyceraldehyde phosphate dehydrogenase activity
has related synonym: NADH-glyceraldehyde phosphate dehydrogenase activity
has related synonym: phosphoglyceraldehyde dehydrogenase activity
has related synonym: triosephosphate dehydrogenase activity

glycerol-3-phosphate O-acyltransferase activity
type: Class
subclass of: GO_0008374
IAO_0000115: Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.
has related synonym: 3-glycerophosphate acyltransferase activity
has related synonym: ACP:sn-glycerol-3-phosphate acyltransferase activity
has related synonym: acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase activity
has related synonym: alpha-glycerophosphate acyltransferase activity
has related synonym: glycerol 3-phosphate acyltransferase activity
has related synonym: glycerol phosphate acyltransferase activity
has related synonym: glycerol phosphate transacylase activity
has related synonym: glycerophosphate acyltransferase activity
has related synonym: glycerophosphate transacylase activity
has related synonym: sn-glycerol 3-phosphate acyltransferase activity
has related synonym: sn-glycerol-3-phosphate acyltransferase activity

glycerol-3-phosphate dehydrogenase [NAD+] activity
type: Class
subclass of: GO_0047952
IAO_0000115: Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+.
has related synonym: alpha-glycerol phosphate dehydrogenase (NAD) activity
has related synonym: alpha-glycerophosphate dehydrogenase (NAD) activity
has related synonym: glycerol 1-phosphate dehydrogenase activity
has related synonym: glycerol-3-phosphate dehydrogenase (NAD) activity
has related synonym: glycerol phosphate dehydrogenase (NAD) activity
has related synonym: glycerophosphate dehydrogenase (NAD) activity
has related synonym: hydroglycerophosphate dehydrogenase activity
has related synonym: L-alpha-glycerol phosphate dehydrogenase activity
has related synonym: L-alpha-glycerophosphate dehydrogenase activity
has related synonym: L-glycerol phosphate dehydrogenase activity
has related synonym: L-glycerophosphate dehydrogenase activity
has related synonym: NAD-alpha-glycerophosphate dehydrogenase activity
has related synonym: NAD-dependent glycerol-3-phosphate dehydrogenase activity
has related synonym: NAD-dependent glycerol phosphate dehydrogenase activity
has related synonym: NADH-dihydroxyacetone phosphate reductase activity
has related synonym: NAD-L-glycerol-3-phosphate dehydrogenase activity
has related synonym: NAD-linked glycerol 3-phosphate dehydrogenase activity

glycerol-3-phosphate dehydrogenase (quinone) activity
type: Class
subclass of: GO_0016901
IAO_0000115: Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.
has related synonym: FAD-dependent glycerol-3-phosphate dehydrogenase
has related synonym: flavin-linked glycerol-3-phosphate dehydrogenase
has related synonym: glycerol-3-phosphate CoQ reductase
has related synonym: glycerophosphate dehydrogenase activity
has related synonym: L-glycerophosphate dehydrogenase activity
has exact synonym: sn-glycerol-3-phosphate:quinone oxidoreductase activity
has related synonym: sn-glycerol-3-phosphate dehydrogenase activity

glycerol-3-phosphate oxidase activity
type: Class
subclass of: GO_0016899
IAO_0000115: Catalysis of the reaction: sn-glycerol 3-phosphate + O(2) = glycerone phosphate + H(2)O(2).
has related synonym: alpha-glycerophosphate oxidase activity
has related synonym: glycerol-1-phosphate oxidase activity
has related synonym: glycerol phosphate oxidase activity
has related synonym: L-alpha-glycerol-3-phosphate oxidase activity
has related synonym: L-alpha-glycerophosphate oxidase activity
has related synonym: sn-glycerol-3-phosphate:oxygen 2-oxidoreductase activity

glycerol kinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016773
IAO_0000115: Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H(+).
has related synonym: ATP:glycerol 3-phosphotransferase activity
has related synonym: ATP:glycerol-3-phosphotransferase activity
has related synonym: GK
has related synonym: glyceric kinase activity
has related synonym: glycerokinase activity
has related synonym: glycerol kinase (phosphorylating)

glycerone kinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016773
IAO_0000115: Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H(+).
has related synonym: acetol kinase (phosphorylating)
has related synonym: acetol kinase activity
has related synonym: ATP:glycerone phosphotransferase activity
has related synonym: dihydroxyacetone kinase activity

glycine hydroxymethyltransferase activity
type: Class
subclass of: GO_0016742
IAO_0000115: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.
has related synonym: 5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase activity
has related synonym: allothreonine aldolase activity
has related synonym: L-serine hydroxymethyltransferase activity
has related synonym: serine aldolase activity
has related synonym: serine hydroxymethylase activity
has related synonym: serine hydroxymethyltransferase activity
has related synonym: serine transhydroxymethylase activity

glycogen (starch) synthase activity
type: Class
subclass of: GO_0035251
IAO_0000115: Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1).
has exact synonym: glycogen (starch) synthetase activity
has related synonym: UDPG-glycogen synthetase activity
has related synonym: UDPG-glycogen transglucosylase activity
has related synonym: UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity
has related synonym: UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity
has related synonym: UDP-glucose-glycogen glucosyltransferase activity
has related synonym: UDP-glycogen synthase activity
has related synonym: uridine diphosphoglucose-glycogen glucosyltransferase activity

obsolete glycine cleavage system
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reactions: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + carbon dioxide (CO2), followed by S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate = dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + ammonia. Made up of two components, aminomethyltransferase and glycine dehydrogenase (decarboxylating).

glycine dehydrogenase (decarboxylating) activity
type: Class
subclass of: GO_0016642
IAO_0000115: Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2.
has related synonym: glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating)
has related synonym: glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)
has related synonym: glycine-cleavage complex
has related synonym: glycine-cleavage complex P-protein activity
has related synonym: glycine cleavage system P-protein activity
has related synonym: glycine decarboxylase activity
has related synonym: P-protein
has related synonym: protein P1

glycolipid mannosyltransferase activity
type: Class
subclass of: mannosyltransferase activity
IAO_0000115: Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage.
has exact synonym: glycolipid mannosyl transferase activity
replaces: GO_0004580

GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity
type: Class
subclass of: alpha-1,2-mannosyltransferase activity
subclass of: glycolipid mannosyltransferase activity
IAO_0000115: Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.
has related synonym: GDP-D-mannose:D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,2-mannosyltransferase activity
has related synonym: GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase activity
has related synonym: GDP-mannose-oligosaccharide-lipid mannosyltransferase activity
has related synonym: glycolipid 2-alpha-mannosyltransferase activity
has related synonym: guanosine diphosphomannose-oligosaccharide-lipid mannosyltransferase activity
has related synonym: oligosaccharide-lipid mannosyltransferase activity

GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity
type: Class
subclass of: glycolipid mannosyltransferase activity
IAO_0000115: Catalysis of the reaction: beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP + H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->3)-D-mannosyl-D-mannose linkage.
has exact synonym: GDP-D-mannose:D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol 3-alpha-mannosyltransferase activity
has related synonym: GDP-mannose:glycolipid 1,3-alpha-D-mannosyltransferase activity
has related synonym: GDP-mannose-oligosaccharide-lipid mannosyltransferase II
has related synonym: glycolipid 3-alpha-mannosyltransferase activity
has related synonym: guanosine diphosphomannose-oligosaccharide-lipid II mannosyltransferase activity
has related synonym: mannosyltransferase II activity

glycylpeptide N-tetradecanoyltransferase activity
type: Class
subclass of: GO_0016410
subclass of: GO_0019107
IAO_0000115: Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide.
has related synonym: myristoylating enzymes
has related synonym: myristoyl-CoA-protein N-myristoyltransferase activity
has related synonym: myristoyl-coenzyme A:protein N-myristoyl transferase activity
has exact synonym: N-myristoyltransferase activity
has related synonym: peptide N-myristoyltransferase activity
has related synonym: peptide N-tetradecanoyltransferase activity
has related synonym: protein N-myristoyltransferase activity
has related synonym: tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase activity
replaces: GO_0019106

glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity
type: Class
subclass of: GO_0008376
subclass of: GO_0140103
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose.
has related synonym: alpha-3-N-acetylgalactosaminyltransferase activity
has related synonym: A transferase activity
has related synonym: A-transferase activity
has related synonym: blood-group substance A-dependent acetylgalactosaminyltransferase activity
has related synonym: blood-group substance alpha-acetyltransferase activity
has related synonym: fucosylgalactose acetylgalactosaminyltransferase activity
has related synonym: fucosylgalactose alpha-N-acetylgalactosaminyltransferase activity
has related synonym: fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase activity
has related synonym: histo-blood group A acetylgalactosaminyltransferase activity
has related synonym: histo-blood group A glycosyltransferase (Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase)
has related synonym: histo-blood group A transferase activity
has related synonym: UDP-GalNAc:Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase activity
has related synonym: UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity
has related synonym: UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity

fucosylgalactoside 3-alpha-galactosyltransferase activity
type: Class
subclass of: GO_0035250
IAO_0000115: Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose.
has related synonym: [blood group substance] alpha-galactosyltransferase activity
has related synonym: blood-group substance B-dependent galactosyltransferase activity
has related synonym: blood-group substance beta-dependent galactosyltransferase activity
has related synonym: B transferase activity
has related synonym: fucosylglycoprotein 3-alpha-galactosyltransferase activity
has exact synonym: glycoprotein-fucosylgalactoside alpha-galactosyltransferase activity
has related synonym: histo-blood group B transferase activity
has related synonym: histo-blood substance B-dependent galactosyltransferase activity
has related synonym: histo-blood substance beta-dependent galactosyltransferase activity
has related synonym: UDPgalactose:alpha-L-fucosyl-(1,2)-D-galactoside 3-alpha-D-galactosyltransferase activity
has related synonym: UDP-galactose:alpha-L-fucosyl-(1,2)-D-galactoside 3-alpha-D-galactosyltransferase activity
has related synonym: UDPgalactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity
has related synonym: UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity
has related synonym: UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase activity
has related synonym: UDPgalactose:O-alpha-L-fucosyl(1,2)D-galactose alpha-D-galactosyltransferase activity
has related synonym: UDPgalactose:O-alpha-L-fucosyl(1->2)D-galactose alpha-D-galactosyltransferase activity

GDP phosphatase activity
type: Class
subclass of: GO_0017110
IAO_0000115: Catalysis of the reaction: GDP + H2O = GMP + phosphate.
has related synonym: GDPase activity
has related synonym: GDP diphosphatase activity
has related synonym: GDP phosphohydrolase activity
has related synonym: guanosine 5'-diphosphatase activity
has exact synonym: guanosine diphosphatase activity
has exact synonym: guanosine-diphosphatase activity

guanylate cyclase activity
type: Class
subclass of: GO_0009975
subclass of: GO_0016849
subclass of: part-of-parent-6182
IAO_0000115: Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
has related synonym: GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) activity
has related synonym: GTP diphosphate-lyase (cyclizing) activity
has related synonym: guanyl cyclase activity
has exact synonym: guanylyl cyclase activity
has related synonym: receptor guanylate cyclase activity

obsolete membrane-associated guanylate kinase
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: ATP + GMP = ADP + GDP, associated with the cell membrane.

guanylate kinase activity
type: Class
subclass of: GO_0050145
subclass of: part-of-parent-46037
subclass of: part-of-parent-46710
IAO_0000115: Catalysis of the reaction: ATP + GMP = ADP + GDP.
has related synonym: 5'-GMP kinase activity
has related synonym: ATP:(d)GMP phosphotransferase activity
has related synonym: ATP:GMP phosphotransferase activity
has related synonym: deoxyguanylate kinase activity
has related synonym: GMP kinase activity
has related synonym: guanosine monophosphate kinase activity
has related synonym: membrane-associated guanylate kinase

helicase activity
type: Class
subclass of: GO_0140640
subclass of: GO_0140657
IAO_0000115: Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
has exact synonym: ATP-dependent helicase activity
replaces: GO_0008026

heme oxygenase (decyclizing) activity
type: Class
subclass of: GO_0016712
IAO_0000115: Catalysis of the reaction: heme b + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = biliverdin + CO + Fe2+ + H+ + 3 H2O + 3 oxidized [NADPH-hemoprotein reductase].
has related synonym: haem oxidase activity
has exact synonym: haem oxygenase (decyclizing) activity
has related synonym: haem oxygenase activity
has related synonym: heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)
has related synonym: heme oxidase activity
has related synonym: heme oxygenase activity
has related synonym: ORP33 proteins

heparan sulfate 2-O-sulfotransferase activity
type: Class
subclass of: GO_0034483
IAO_0000115: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate.
has exact synonym: heparan-sulfate 2-O-sulphotransferase activity
has related synonym: heparin 2-sulfotransferase activity
has related synonym: heparin-sulphate 2-sulphotransferase activity

hexaprenyldihydroxybenzoate methyltransferase activity
type: Class
subclass of: GO_0010420
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate.
has related synonym: 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase activity
has related synonym: DHHB methyltransferase activity
has related synonym: DHHB-Mt activity
has related synonym: dihydroxyhexaprenylbenzoate methyltransferase activity
has related synonym: S-adenosyl-L-methionine:3-hexaprenyl-4,5-dihydroxylate O-methyltransferase activity

hexokinase activity
type: Class
subclass of: GO_0016773
subclass of: GO_0019200
IAO_0000115: Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate.
has related synonym: ATP:D-hexose 6-phosphotransferase activity
has related synonym: ATP-dependent hexokinase activity
has related synonym: glucose ATP phosphotransferase activity
has related synonym: hexokinase (phosphorylating)
has related synonym: hexokinase D
has related synonym: hexokinase type I activity
has related synonym: hexokinase type II activity
has related synonym: hexokinase type III activity
has related synonym: hexokinase type IV
has related synonym: hexokinase type IV (glucokinase) activity
has related synonym: hexokinase type IV glucokinase activity

histidine ammonia-lyase activity
type: Class
subclass of: GO_0016841
IAO_0000115: Catalysis of the reaction: L-histidine = urocanate + NH3.
has related synonym: histidase activity
has related synonym: histidinase activity
has related synonym: histidine alpha-deaminase activity
has related synonym: L-histidine ammonia-lyase (urocanate-forming)
has related synonym: L-histidine ammonia-lyase activity

histidine decarboxylase activity
type: Class
subclass of: GO_0016831
IAO_0000115: Catalysis of the reaction: L-histidine = histamine + CO2.
has related synonym: L-histidine carboxy-lyase (histamine-forming)
has related synonym: L-histidine carboxy-lyase activity
has related synonym: L-histidine decarboxylase activity

histidinol dehydrogenase activity
type: Class
subclass of: GO_0016616
IAO_0000115: Catalysis of the reaction: L-histidinol + NAD+ = L-histidine + NADH + H+.

histidinol-phosphate transaminase activity
type: Class
subclass of: GO_0008483
IAO_0000115: Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.
has related synonym: glutamic-imidazoleacetol phosphate transaminase activity
has related synonym: histidine:imidazoleacetol phosphate transaminase activity
has related synonym: histidinol phosphate aminotransferase activity
has exact synonym: histidinol-phosphate aminotransferase activity
has related synonym: IAP transaminase activity
has related synonym: imidazoleacetol phosphate transaminase activity
has related synonym: imidazole acetol-phosphate transaminase activity
has related synonym: imidazolylacetolphosphate aminotransferase activity
has related synonym: imidazolylacetolphosphate transaminase activity
has related synonym: L-histidinol-phosphate:2-oxoglutarate aminotransferase activity
has related synonym: L-histidinol phosphate aminotransferase activity

histidinol-phosphatase activity
type: Class
subclass of: GO_0016791
IAO_0000115: Catalysis of the reaction: L-histidinol phosphate + H(2)O = L-histidinol + phosphate.
has related synonym: histidinolphosphatase activity
has related synonym: histidinolphosphate phosphatase activity
has related synonym: histidinol phosphate phosphatase activity
has related synonym: HPpase activity
has related synonym: L-histidinol phosphate phosphatase activity
has related synonym: L-histidinol-phosphate phosphohydrolase activity

histone acetyltransferase activity
type: Class
subclass of: GO_0061733
subclass of: part-of-parent-16573
IAO_0000115: Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone.
has related synonym: acetyl-CoA:histone acetyltransferase activity
has related synonym: H2A/H2B histone acetyltransferase activity
has related synonym: H3/H4 histone acetyltransferase activity
has related synonym: H4/H2A acetyltransferase activity
has related synonym: H4/H2 histone acetyltransferase activity
has related synonym: histone acetokinase activity
has exact synonym: histone acetylase activity
has exact synonym: histone lysine acetyltransferase activity
has related synonym: histone transacetylase activity
has related synonym: nucleosome-histone acetyltransferase activity
replaces: GO_0004403
replaces: GO_0004404
replaces: GO_0004405
replaces: GO_0004406
replaces: GO_0043166
replaces: GO_0046971

histone deacetylase activity
type: Class
subclass of: GO_0016811
subclass of: GO_0033558
IAO_0000115: Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.

holocytochrome-c synthase activity
type: Class
subclass of: GO_0016846
subclass of: GO_0140096
IAO_0000115: Catalysis of the reaction: holocytochrome c = apocytochrome c + heme.
has related synonym: cytochrome c heme-lyase activity
has related synonym: cytochrome c synthase activity
has related synonym: holocytochrome-c apocytochrome-c-lyase (heme-forming)
has related synonym: holocytochrome-c apocytochrome-c-lyase activity
has related synonym: holocytochrome c synthetase activity

homoaconitate hydratase activity
type: Class
subclass of: GO_0016836
IAO_0000115: Catalysis of the reaction: (-)-homoisocitrate = cis-homoaconitate + H(2)O.
has related synonym: (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(Z)-but-1-ene-1,2,4-tricarboxylate-forming]
has related synonym: 2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase activity
has related synonym: cis-homoaconitase activity
has related synonym: HACN activity
has related synonym: homoaconitase activity
has related synonym: Lys4
has related synonym: LysF

homocitrate synthase activity
type: Class
subclass of: GO_0046912
IAO_0000115: Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H(2)O = CoA + H(+) + homocitrate.
has related synonym: 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating)
has related synonym: 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity
has related synonym: acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)
has related synonym: acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase activity
has related synonym: homocitrate synthetase activity

homogentisate 1,2-dioxygenase activity
type: Class
subclass of: GO_0016702
IAO_0000115: Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+).
has related synonym: homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
has related synonym: homogentisate dioxygenase activity
has related synonym: homogentisate oxidase activity
has related synonym: homogentisate oxygenase activity
has related synonym: homogentisic acid oxidase activity
has related synonym: homogentisic acid oxygenase activity
has related synonym: homogentisicase activity
has related synonym: homogentisic oxygenase activity

homoserine dehydrogenase activity
type: Class
subclass of: GO_0016616
IAO_0000115: Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+.

homoserine kinase activity
type: Class
subclass of: GO_0016773
subclass of: GO_0019202
IAO_0000115: Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H(+).
has related synonym: ATP:L-homoserine O-phosphotransferase activity
has related synonym: homoserine kinase (phosphorylating)
has related synonym: HSK

homoserine O-acetyltransferase activity
type: Class
subclass of: GO_0016413
IAO_0000115: Catalysis of the reaction: L-homoserine + acetyl-CoA = O-acetyl-L-homoserine + CoA.
has related synonym: acetyl-CoA:L-homoserine O-acetyltransferase activity
has related synonym: homoserine acetyltransferase activity
has related synonym: homoserine O-trans-acetylase activity
has related synonym: homoserine-O-transacetylase activity
has related synonym: homoserine transacetylase activity
has related synonym: L-homoserine O-acetyltransferase activity

hyalurononglucosaminidase activity
type: Class
subclass of: GO_0015929
IAO_0000115: Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.
has related synonym: chondroitinase activity
has related synonym: chondroitinase I activity
has related synonym: hyaluronate 4-glycanohydrolase activity
has related synonym: hyaluronidase activity
has exact synonym: hyaluronoglucosaminidase activity
has related synonym: hyaluronoglucosidase activity

hydroxyacylglutathione hydrolase activity
type: Class
subclass of: GO_0016790
IAO_0000115: Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate.
has related synonym: acetoacetylglutathione hydrolase activity
has related synonym: glyoxalase II activity
has related synonym: S-(2-hydroxyacyl)glutathione hydrolase activity
has related synonym: S-2-hydroxylacylglutathione hydrolase activity

hydroxyethylthiazole kinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016773
IAO_0000115: Catalysis of the reaction: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP + 2 H(+).
has related synonym: 4-methyl-5-(beta-hydroxyethyl)thiazole kinase activity
has related synonym: ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase activity
has related synonym: hydroxyethylthiazole kinase (phosphorylating)

hydroxymethylbilane synthase activity
type: Class
subclass of: GO_0016765
IAO_0000115: Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+).
has related synonym: (4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity
has related synonym: (4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)
has related synonym: HMB-synthase activity
has related synonym: porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)
has related synonym: porphobilinogen ammonia-lyase (polymerizing)
has related synonym: porphobilinogen deaminase activity
has related synonym: pre-uroporphyrinogen synthase activity
has related synonym: uroporphyrinogen I synthase activity
has related synonym: uroporphyrinogen I synthetase activity
has related synonym: uroporphyrinogen synthase activity
has related synonym: uroporphyrinogen synthetase activity

hydroxymethylglutaryl-CoA lyase activity
type: Class
subclass of: GO_0016833
IAO_0000115: Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA.
has related synonym: (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming)
has related synonym: (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase activity
has related synonym: 3-hydroxy-3-methylglutarate-CoA lyase activity
has related synonym: 3-hydroxy-3-methylglutaryl CoA cleaving enzyme
has related synonym: 3-hydroxy-3-methylglutaryl-CoA lyase activity
has related synonym: 3-hydroxy-3-methylglutaryl coenzyme A lyase activity
has related synonym: HMG-CoA lyase activity
has related synonym: hydroxymethylglutaryl coenzyme A-cleaving enzyme
has related synonym: hydroxymethylglutaryl coenzyme A lyase activity

hydroxymethylglutaryl-CoA reductase (NADPH) activity
type: Class
subclass of: GO_0016616
IAO_0000115: Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH.
has related synonym: 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity
has related synonym: HMG-CoA reductase activity
has related synonym: hydroxymethylglutaryl-CoA reductase activity
replaces: GO_0042282

hydroxymethylglutaryl-CoA synthase activity
type: Class
subclass of: GO_0046912
IAO_0000115: Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+).
has related synonym: (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)
has related synonym: (s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity
has related synonym: 3-hydroxy-3-methylglutaryl-CoA synthase activity
has related synonym: 3-hydroxy-3-methylglutaryl CoA synthetase activity
has related synonym: 3-hydroxy-3-methylglutaryl coenzyme A synthase activity
has related synonym: 3-hydroxy-3-methylglutaryl-coenzyme A synthase activity
has related synonym: 3-hydroxy-3-methylglutaryl coenzyme A synthetase activity
has related synonym: acetoacetyl coenzyme A transacetase activity
has related synonym: acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
has related synonym: beta-hydroxy-beta-methylglutaryl-CoA synthase activity
has related synonym: HMG-CoA synthase activity
has related synonym: hydroxymethylglutaryl coenzyme A-condensing enzyme
has related synonym: hydroxymethylglutaryl coenzyme alpha-condensing enzyme activity
has related synonym: hydroxymethylglutaryl coenzyme A synthase activity

hypoxanthine phosphoribosyltransferase activity
type: Class
subclass of: GO_0106130
IAO_0000115: Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
has related synonym: 6-hydroxypurine phosphoribosyltransferase activity
has related synonym: 6-mercaptopurine phosphoribosyltransferase activity
has related synonym: guanine-hypoxanthine phosphoribosyltransferase activity
has related synonym: HGPRTase activity
has related synonym: HPRT
has related synonym: hypoxanthine-guanine phosphoribosyltransferase activity
has related synonym: IMP:diphosphate phospho-D-ribosyltransferase activity
has related synonym: IMP diphosphorylase activity
has related synonym: IMP-GMP pyrophosphorylase activity
has related synonym: IMP pyrophosphorylase activity
has related synonym: inosinate pyrophosphorylase activity
has related synonym: inosine 5'-phosphate pyrophosphorylase activity
has related synonym: inosinic acid pyrophosphorylase activity
has related synonym: inosinic pyrophosphorylase activity
has related synonym: purine-6-thiol phosphoribosyltransferase activity
has related synonym: Transphosphoribosidase activity

iduronate-2-sulfatase activity
type: Class
subclass of: GO_0008484
IAO_0000115: Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin.
has related synonym: 2-sulfo-L-iduronate 2-sulfatase activity
has related synonym: chondroitinsulfatase
has related synonym: iduronate-2-sulfate sulfatase activity
has exact synonym: iduronate-2-sulphatase activity
has related synonym: iduronate sulfatase activity
has related synonym: iduronate sulfate sulfatase activity
has related synonym: iduronide-2-sulfate sulfatase activity
has related synonym: idurono-2-sulfatase activity
has related synonym: L-iduronate-2-sulfate 2-sulfohydrolase activity
has related synonym: L-iduronate 2-sulfate sulfatase activity
has related synonym: L-iduronosulfatase activity
has related synonym: L-idurono sulfate sulfatase activity
has related synonym: sulfoiduronate sulfohydrolase activity
has related synonym: sulfo-L-iduronate sulfatase activity

imidazoleglycerol-phosphate dehydratase activity
type: Class
subclass of: GO_0016836
IAO_0000115: Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O.
has related synonym: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase [3-(imidazol-4-yl)-2-oxopropyl-phosphate-forming]
has related synonym: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase activity
has related synonym: IGP dehydratase activity
has exact synonym: imidazoleglycerol phosphate dehydratase activity

indole-3-glycerol-phosphate synthase activity
type: Class
subclass of: GO_0016831
IAO_0000115: Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O.
has related synonym: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase (cyclizing)
has related synonym: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase [cyclizing; 1-C-(3-indolyl)-glycerol-3-phosphate-forming]
has related synonym: indole-3-glycerophosphate synthase activity
has related synonym: indoleglycerol phosphate synthase activity
has related synonym: indoleglycerol phosphate synthetase activity

inorganic diphosphate phosphatase activity
type: Class
subclass of: GO_0016462
IAO_0000115: Catalysis of the reaction: diphosphate + H2O = H+ + 2 phosphate.
has related synonym: diphosphate phosphohydrolase activity
has exact synonym: inorganic diphosphatase activity
has related synonym: inorganic pyrophosphatase activity
has related synonym: pyrophosphate phosphohydrolase activity

obsolete inositol or phosphatidylinositol kinase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the phosphorylation of myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol.

1-phosphatidylinositol 4-kinase activity
type: Class
subclass of: GO_0052742
IAO_0000115: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+).
has related synonym: ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase activity
has related synonym: phosphatidylinositol 4-kinase activity
has related synonym: phosphatidylinositol kinase (phosphorylating) activity
has related synonym: phosphatidylinositol kinase activity
has related synonym: PI4K
has related synonym: PI4K-alpha activity
has related synonym: PI4-kinase activity
has related synonym: PI 4-kinase activity
has related synonym: PI kinase activity
has related synonym: PtdIns-4-kinase activity
has related synonym: type II phosphatidylinositol kinase activity

obsolete 1-phosphatidylinositol-4-phosphate kinase, class IA
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A class I PI3K activated by tyrosine phosphorylation events.

obsolete 1-phosphatidylinositol-4-phosphate kinase, class IB
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A class I PI3K activated via heterotrimeric G-proteins.

phosphatidylinositol phospholipase C activity
type: Class
subclass of: phospholipase C activity
IAO_0000115: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).
has related synonym: 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity
has related synonym: 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity
has exact synonym: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity
has related synonym: monophosphatidylinositol phosphodiesterase activity
has related synonym: phosphatidylinositol-4,5-bisphosphate hydrolysis
has related synonym: phosphoinositidase C activity
has related synonym: phosphoinositide phospholipase C activity
has related synonym: PI-PLC activity
has related synonym: triphosphoinositide phosphodiesterase activity

phosphatidylinositol diacylglycerol-lyase activity
type: Class
subclass of: GO_0016849
IAO_0000115: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol = D-myo-inositol 1,2-cyclic phosphate + diacylglycerol.
has related synonym: 1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming)
has related synonym: 1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming)
has related synonym: 1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming)
has exact synonym: 1-phosphatidylinositol phosphodiesterase activity
has related synonym: monophosphatidylinositol phosphodiesterase activity

obsolete inositol or phosphatidylinositol phosphatase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol.

phosphatidylinositol-3-phosphatase activity
type: Class
subclass of: GO_0052744
IAO_0000115: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.
has related synonym: 1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase activity
has related synonym: D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase activity
has related synonym: inositol-1,3-bisphosphate 3-phosphatase activity
has related synonym: inositol 1,3-bisphosphate phosphatase activity
has exact synonym: inositol-1,4,-bisphosphate 3-phosphatase activity
has related synonym: inositol-polyphosphate 3-phosphatase activity
has related synonym: phosphatidyl-3-phosphate 3-phosphohydrolase activity
replaces: GO_0016315

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
type: Class
subclass of: GO_0034595
subclass of: GO_0106019
IAO_0000115: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
has related synonym: phosphatidylinositol 4,5-bisphosphate phosphatase activity
has related synonym: phosphatidylinositol-bisphosphatase activity
has related synonym: phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase activity
has exact synonym: PI(4,5)P2 5-phosphatase activity
has related synonym: PtdIns(4,5)P(2) 5-phosphatase activity
has related synonym: PtdIns(4,5)P2 5-phosphatase activity
has related synonym: triphosphoinositide phosphatase activity
has related synonym: triphosphoinositide phosphomonoesterase activity
replaces: GO_0001668

inositol-1,4-bisphosphate 1-phosphatase activity
type: Class
subclass of: GO_0016312
IAO_0000115: Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate.
has related synonym: 1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase activity
has related synonym: inositol polyphosphate 1-phosphatase activity
has related synonym: inositol-polyphosphate 1-phosphatase activity

obsolete inositol-1,4,-bisphosphate 3-phosphatase
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: D-myo-inositol 1,3-bisphosphate + H2O = D-myo-inositol 1-monophosphate + phosphate.

obsolete inositol-1,4,-bisphosphate 4-phosphatase
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: D-myo-inositol 3,4-bisphosphate + H2O = D-myo-inositol 3-monophosphate + phosphate.

obsolete inositol-1,4,5-trisphosphate 1-phosphatase
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. The removal of a phosphate group from the carbon-1 position of D-myo-inositol 1,4,5-trisphosphate.

inositol-polyphosphate 5-phosphatase activity
type: Class
subclass of: GO_0046030
IAO_0000115: Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.
has related synonym: 1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase activity
has related synonym: 5PTase activity
has related synonym: D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase activity
has related synonym: D-myo-inositol 1,4,5-triphosphate 5-phosphatase activity
has related synonym: D-myo-inositol 1,4,5-trisphosphate 5-phosphatase activity
has related synonym: inosine triphosphatase activity
has related synonym: inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase activity
has related synonym: inositol-1,4,5-trisphosphate 5-phosphatase activity
has related synonym: inositol 1,4,5-trisphosphate phosphatase activity
has related synonym: inositol phosphate 5-phosphomonoesterase activity
has related synonym: inositol polyphosphate-5-phosphatase activity
has related synonym: inositol triphosphate 5-phosphomonoesterase activity
has related synonym: inositol trisphosphate phosphomonoesterase activity
has related synonym: Ins(1,4,5)P(3) 5-phosphatase activity
has related synonym: Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase activity
has related synonym: Ins(1,4,5)P3 5-phosphatase activity
has related synonym: InsP(3)/Ins(1,3,4,5)P(4) 5-phosphatase activity
has related synonym: InsP3/Ins(1,3,4,5)P4 5-phosphatase activity
has related synonym: L-myo-inositol 1,4,5-trisphosphate-monoesterase activity
has related synonym: myo-inositol-1,4,5-trisphosphate 5-phosphatase activity
has related synonym: type II inositol-1,4,5-trisphosphate 5-phosphatase activity
has related synonym: type II inositol polyphosphate 5-phosphatase activity
has related synonym: type I inositol-polyphosphate phosphatase activity

inositol-hexakisphosphate phosphatase activity
type: Class
subclass of: GO_0052745
IAO_0000115: Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate.
has related synonym: 1D-myo-inositol-hexakisphosphate 5-phosphohydrolase activity
has related synonym: inositol tetrakisphosphate phosphomonoesterase activity
has related synonym: MIPP activity
has related synonym: multiple inositol-polyphosphate phosphatase activity

iodide peroxidase activity
type: Class
subclass of: peroxidase activity
IAO_0000115: Catalysis of the reaction: iodide + hydrogen peroxide = iodine + 2 H2O.
has related synonym: iodinase activity
has related synonym: thyroid peroxidase activity
has related synonym: thyroperoxidase activity
has related synonym: TPO activity

isocitrate dehydrogenase [NAD(P)+] activity
type: Class
subclass of: GO_0016616
IAO_0000115: Catalysis of the reaction: isocitrate + NAD(P)+ = 2-oxoglutarate + CO2 + NAD(P)H.
has related synonym: IDH activity
has related synonym: IDP activity
has exact synonym: isocitrate dehydrogenase activity
has exact synonym: isocitric acid dehydrogenase activity
has exact synonym: isocitric dehydrogenase activity
has exact synonym: oxalosuccinate carboxylase activity
has exact synonym: oxalosuccinate decarboxylase activity
has exact synonym: oxalosuccinic decarboxylase activity

isocitrate dehydrogenase (NAD+) activity
type: Class
subclass of: isocitrate dehydrogenase [NAD(P)+] activity
IAO_0000115: Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.
has exact synonym: isocitrate:NAD+ oxidoreductase (decarboxylating)
has exact synonym: isocitrate dehydrogenase (NAD) activity
has exact synonym: NAD dependent isocitrate dehydrogenase activity
has exact synonym: NAD isocitrate dehydrogenase activity
has exact synonym: NAD isocitric dehydrogenase activity
has exact synonym: NAD-linked isocitrate dehydrogenase activity
has exact synonym: NAD-specific isocitrate dehydrogenase activity
has exact synonym: nicotinamide adenine dinucleotide isocitrate dehydrogenase activity

isocitrate dehydrogenase (NADP+) activity
type: Class
subclass of: isocitrate dehydrogenase [NAD(P)+] activity
IAO_0000115: Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.
has related synonym: dual-cofactor-specific isocitrate dehydrogenase activity
has exact synonym: isocitrate:NADP+ oxidoreductase (decarboxylating)
has exact synonym: isocitrate (NADP) dehydrogenase activity
has exact synonym: isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity
has exact synonym: isocitrate dehydrogenase (NADP) activity
has exact synonym: isocitrate dehydrogenase (NADP-dependent) activity
has related synonym: NADP(+)-ICDH activity
has related synonym: NADP(+)-IDH activity
has exact synonym: NADP(+)-linked isocitrate dehydrogenase activity
has exact synonym: NADP-dependent isocitrate dehydrogenase activity
has exact synonym: NADP-dependent isocitric dehydrogenase activity
has exact synonym: NADP isocitric dehydrogenase activity
has exact synonym: NADP-linked isocitrate dehydrogenase activity
has exact synonym: NADP-specific isocitrate dehydrogenase activity
has exact synonym: triphosphopyridine nucleotide-linked isocitrate dehydrogenase activity

isocitrate lyase activity
type: Class
subclass of: GO_0016833
IAO_0000115: Catalysis of the reaction: isocitrate = glyoxylate + succinate.
has related synonym: ICL activity
has related synonym: isocitrase activity
has related synonym: isocitratase activity
has related synonym: isocitrate glyoxylate-lyase (succinate-forming)
has related synonym: isocitrate glyoxylate-lyase activity
has related synonym: isocitritase activity
has related synonym: threo-DS-isocitrate glyoxylate-lyase activity

isopentenyl-diphosphate delta-isomerase activity
type: Class
subclass of: GO_0016863
IAO_0000115: Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate.
has related synonym: IPP isomerase activity
has related synonym: isopentenyl-diphosphate delta3-delta2-isomerase activity
has exact synonym: isopentenyl-diphosphate D-isomerase activity
has related synonym: isopentenylpyrophosphate delta-isomerase activity
has related synonym: isopentenylpyrophosphate isomerase activity
has related synonym: methylbutenylpyrophosphate isomerase activity

juvenile-hormone esterase activity
type: Class
subclass of: GO_0052689
IAO_0000115: Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone.
has related synonym: JH esterase activity
has related synonym: JH-esterase activity
has related synonym: juvenile hormone analog esterase activity
has related synonym: juvenile hormone carboxyesterase activity
has related synonym: methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase activity

ketohexokinase activity
type: Class
subclass of: GO_0016773
subclass of: GO_0019200
IAO_0000115: Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate.
has related synonym: ATP:D-fructose 1-phosphotransferase activity
has related synonym: hepatic fructokinase activity
has related synonym: ketohexokinase (phosphorylating)

ketol-acid reductoisomerase activity
type: Class
subclass of: GO_0016616
IAO_0000115: Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+.
has related synonym: (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)
has related synonym: 2-hydroxy-3-keto acid reductoisomerase activity
has related synonym: acetohydroxy acid isomeroreductase activity
has related synonym: acetohydroxy acid reductoisomerase activity
has related synonym: acetolactate reductoisomerase activity
has related synonym: alpha-keto-beta-hydroxylacyl reductoisomerase activity
has related synonym: dihydroxyisovalerate (isomerizing) dehydrogenase activity
has related synonym: dihydroxyisovalerate dehydrogenase (isomerizing) activity
has related synonym: isomeroreductase activity
has related synonym: ketol acid reductoisomerase activity
has related synonym: reductoisomerase activity

phosphogluconate dehydratase activity
type: Class
subclass of: GO_0016836
IAO_0000115: Catalysis of the reaction: 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H(2)O.
has related synonym: 6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming)
has related synonym: 6-phospho-D-gluconate hydro-lyase activity
has related synonym: 6-phosphogluconate dehydrase activity
has related synonym: 6-phosphogluconate dehydratase activity
has related synonym: 6-phosphogluconic dehydrase activity
has related synonym: gluconate 6-phosphate dehydratase activity
has related synonym: gluconate-6-phosphate dehydratase activity

lactate dehydrogenase activity
type: Class
subclass of: GO_0016614
IAO_0000115: Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate.

D-lactate dehydrogenase (cytochrome) activity
type: Class
subclass of: lactate dehydrogenase activity
subclass of: GO_0016898
IAO_0000115: Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate.
has exact synonym: (R)-lactate:ferricytochrome-c 2-oxidoreductase activity
has related synonym: cytochrome-dependent D-(-)-lactate dehydrogenase activity
has related synonym: D-(-)-lactic cytochrome c reductase activity
has related synonym: D-lactate (cytochrome) dehydrogenase activity
has related synonym: D-lactate-cytochrome c reductase activity
has related synonym: D-lactate ferricytochrome c oxidoreductase activity
has related synonym: lactic acid dehydrogenase activity

L-lactate dehydrogenase activity
type: Class
subclass of: lactate dehydrogenase activity
subclass of: GO_0016616
IAO_0000115: Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.
has related synonym: L-lactic acid dehydrogenase activity
has related synonym: L-lactic dehydrogenase activity

L-lactate dehydrogenase (cytochrome) activity
type: Class
subclass of: lactate dehydrogenase activity
subclass of: GO_0016898
IAO_0000115: Catalysis of the reaction: (S)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate.
has related synonym: (S)-lactate:ferricytochrome-c 2-oxidoreductase activity
has related synonym: cytochrome b2
has related synonym: cytochrome b2 (flavin-free derivative of flavocytochrome b2)
has related synonym: dehydrogenase, lactate (cytochrome)
has related synonym: flavocytochrome b2
has related synonym: L(+)-lactate:cytochrome c oxidoreductase activity
has related synonym: lactate dehydrogenase (cytochrome)
has related synonym: lactic acid dehydrogenase activity
has related synonym: lactic cytochrome c reductase activity
has related synonym: L-lactate cytochrome c oxidoreductase activity
has related synonym: L-lactate cytochrome c reductase activity
has related synonym: L-lactate ferricytochrome c oxidoreductase activity

lactose synthase activity
type: Class
subclass of: GO_0035250
IAO_0000115: Catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose.
has related synonym: lactose synthetase activity
has related synonym: UDPgalactose:D-glucose 4-beta-D-galactotransferase activity
has related synonym: UDP-galactose:D-glucose 4-beta-D-galactotransferase activity
has related synonym: UDPgalactose-glucose galactosyltransferase activity
has related synonym: UDP-galactose-glucose galactosyltransferase activity
has related synonym: uridine diphosphogalactose-glucose galactosyltransferase activity

lactoylglutathione lyase activity
type: Class
subclass of: GO_0016846
IAO_0000115: Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal.
has related synonym: (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming)
has related synonym: (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing) activity
has related synonym: aldoketomutase activity
has related synonym: glyoxalase I activity
has related synonym: glyoxylase I
has related synonym: ketone-aldehyde mutase activity
has related synonym: methylglyoxalase activity

leukotriene-A4 hydrolase activity
type: Class
subclass of: GO_0016803
IAO_0000115: Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4).
has related synonym: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase activity
has related synonym: leukotriene A(4) hydrolase activity
has related synonym: leukotriene A4 hydrolase activity
has related synonym: LTA4H
has related synonym: LTA4 hydrolase activity
has related synonym: LTA-4 hydrolase activity

leukotriene-C4 synthase activity
type: Class
subclass of: GO_0016846
IAO_0000115: Catalysis of the reaction: leukotriene C(4) = glutathione + leukotriene A(4).
has related synonym: (7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening)
has related synonym: (7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming)
has related synonym: leukotriene A(4):glutathione S-leukotrienyltransferase activity
has related synonym: leukotriene A4:glutathione S-leukotrienyltransferase activity
has related synonym: leukotriene C(4) synthetase activity
has related synonym: leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)
has related synonym: leukotriene C4 synthetase activity
has related synonym: LTC(4) synthase activity
has related synonym: LTC(4) synthetase activity
has related synonym: LTC4 synthase activity
has related synonym: LTC4 synthetase activity

lipoprotein lipase activity
type: Class
subclass of: triglyceride lipase activity
IAO_0000115: Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein.
has related synonym: clearing factor lipase activity
has related synonym: diacylglycerol hydrolase activity
has related synonym: diacylglycerol lipase activity
has related synonym: diglyceride lipase activity
has related synonym: lipemia-clearing factor
has related synonym: postheparin esterase activity
has related synonym: postheparin lipase activity
has related synonym: triacylglycero-protein acylhydrolase activity

long-chain-acyl-CoA dehydrogenase activity
type: Class
subclass of: acyl-CoA dehydrogenase activity
IAO_0000115: Catalysis of the reaction: a long-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein].
has related synonym: long-chain acyl-coenzyme A dehydrogenase activity
has related synonym: palmitoyl-CoA dehydrogenase activity
has related synonym: palmitoyl-coenzyme A dehydrogenase activity

long-chain fatty acid-CoA ligase activity
type: Class
subclass of: GO_0015645
subclass of: GO_0016405
subclass of: part-of-parent-1676
IAO_0000115: Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
has related synonym: acyl-activating enzyme activity
has related synonym: acyl-CoA ligase activity
has related synonym: acyl-CoA synthetase activity
has related synonym: fatty acid thiokinase (long-chain) activity
has related synonym: LCFA synthetase activity
has related synonym: lignoceroyl-CoA synthase activity
has related synonym: long-chain acyl CoA synthetase activity
has exact synonym: long-chain acyl-CoA synthetase activity
has related synonym: long-chain acyl-coenzyme A synthetase activity
has related synonym: long-chain fatty acid activation
has exact synonym: long-chain-fatty-acid-CoA ligase activity
has related synonym: long chain fatty acyl-CoA synthetase activity
has exact synonym: long-chain-fatty-acyl-CoA synthetase activity
has related synonym: long-chain fatty acyl coenzyme A synthetase activity
has related synonym: pristanoyl-CoA synthetase
has related synonym: stearoyl-CoA synthetase
has related synonym: thiokinase
replaces: GO_0003996

lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
type: Class
subclass of: GO_0008080
IAO_0000115: Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine.
has related synonym: acetyl-phosphate:L-lysine 6-N-acetyltransferase activity
has related synonym: acetyl-phosphate:L-lysine N6-acetyltransferase activity
has related synonym: LAT activity
has exact synonym: lysine acetyltransferase activity
has related synonym: lysine N(6)-acetyltransferase activity
has related synonym: lysine N6-acetyltransferase activity

malic enzyme activity
type: Class
subclass of: GO_0016615
IAO_0000115: Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate.
has related synonym: pyruvic-malic carboxylase activity

malate dehydrogenase (decarboxylating) (NAD+) activity
type: Class
subclass of: malic enzyme activity
subclass of: GO_0016616
IAO_0000115: Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+.
has related synonym: 'malic' enzyme
has related synonym: (S)-malate:NAD+ oxidoreductase (decarboxylating)
has related synonym: (S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating)
has related synonym: malate dehydrogenase (decarboxylating) activity
has exact synonym: malate dehydrogenase (oxaloacetate-decarboxylating) activity
has related synonym: NAD-linked malic enzyme
has related synonym: NAD-malic enzyme activity
has related synonym: NAD-specific malic enzyme
replaces: GO_0004472
replaces: GO_0016619

malate dehydrogenase (decarboxylating) (NADP+) activity
type: Class
subclass of: malic enzyme activity
subclass of: GO_0016616
IAO_0000115: Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+.
has related synonym: 'malic' enzyme
has related synonym: (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)
has related synonym: L-malate:NADP oxidoreductase activity
has related synonym: malate dehydrogenase (decarboxylating, NADP)
has related synonym: malate dehydrogenase (NADP, decarboxylating)
has related synonym: NADP-linked decarboxylating malic enzyme
has related synonym: NADP-malic enzyme activity
has related synonym: NADP-specific malate dehydrogenase activity
has related synonym: NADP-specific malic enzyme

malate synthase activity
type: Class
subclass of: GO_0046912
IAO_0000115: Catalysis of the reaction: acetyl-CoA + glyoxylate + H(2)O = (S)-malate + CoA + H(+).
has related synonym: acetyl-CoA:glyoxylate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
has related synonym: glyoxylate transacetase activity
has related synonym: glyoxylate transacetylase activity
has related synonym: glyoxylic transacetase activity
has related synonym: L-malate glyoxylate-lyase (CoA-acetylating) activity
has related synonym: malate condensing enzyme activity
has related synonym: malate synthetase activity
has related synonym: malic-condensing enzyme activity
has related synonym: malic synthetase activity

mannose-1-phosphate guanylyltransferase activity
type: Class
subclass of: GO_0008905
IAO_0000115: Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose.
has related synonym: GDP-mannose pyrophosphorylase activity
has related synonym: GTP:alpha-D-mannose-1-phosphate guanylyltransferase activity
has exact synonym: GTP:mannose-1-phosphate guanylyltransferase activity
has related synonym: GTP-mannose-1-phosphate guanylyltransferase activity
has related synonym: guanosine 5'-diphospho-D-mannose pyrophosphorylase activity
has related synonym: guanosine diphosphomannose pyrophosphorylase activity
has related synonym: guanosine triphosphate-mannose 1-phosphate guanylyltransferase activity
has related synonym: mannose 1-phosphate guanylyltransferase (guanosine triphosphate)
has related synonym: PIM-GMP (phosphomannose isomerase-guanosine 5'-diphospho-D-mannose pyrophosphorylase)

mannose-6-phosphate isomerase activity
type: Class
subclass of: GO_0016861
IAO_0000115: Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate.
has related synonym: D-mannose-6-phosphate aldose-ketose-isomerase activity
has related synonym: D-mannose-6-phosphate ketol-isomerase activity
has related synonym: mannose phosphate isomerase activity
has related synonym: phosphohexoisomerase activity
has related synonym: phosphohexomutase activity
has related synonym: phosphomannoisomerase activity
has related synonym: phosphomannose isomerase activity

methenyltetrahydrofolate cyclohydrolase activity
type: Class
subclass of: GO_0019238
IAO_0000115: Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.
has related synonym: 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)
has exact synonym: 5,10-methenyl-THF cyclohydrolase activity
has related synonym: citrovorum factor cyclodehydrase activity
has related synonym: formyl-methenyl-methylenetetrahydrofolate synthetase (combined)

methionine adenosyltransferase activity
type: Class
subclass of: GO_0016765
IAO_0000115: Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.
has related synonym: adenosylmethionine synthetase activity
has related synonym: AdoMet synthetase activity
has related synonym: ATP:L-methionine S-adenosyltransferase activity
has related synonym: ATP-methionine adenosyltransferase activity
has related synonym: methionine-activating enzyme
has related synonym: methionine S-adenosyltransferase activity
has related synonym: S-adenosyl-L-methionine synthetase activity
has related synonym: S-adenosylmethionine synthase activity
has related synonym: S-adenosylmethionine synthetase activity

methionyl-tRNA formyltransferase activity
type: Class
subclass of: GO_0016742
subclass of: GO_0140101
subclass of: part-of-parent-6413
subclass of: part-of-parent-71951
IAO_0000115: Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA.
has related synonym: 10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase activity
has related synonym: conversion of met-tRNAf to fmet-tRNA
has related synonym: conversion of mitochondrial met-tRNAf to fmet-tRNA
has related synonym: formylmethionyl-transfer ribonucleic synthetase activity
has related synonym: methionyl ribonucleic formyltransferase activity
has related synonym: methionyl-transfer ribonucleate methyltransferase activity
has related synonym: methionyl-transfer ribonucleic transformylase activity
has related synonym: methionyl-transfer RNA transformylase activity
has related synonym: methionyl-tRNA Met formyltransferase activity
has related synonym: methionyl-tRNA transformylase activity
has related synonym: mitochondrial N-terminal peptidyl-methionine N-formylation
has related synonym: N(10)-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity
has related synonym: N10-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity
has related synonym: N-terminal peptidyl-methionine N-formylation
replaces: GO_0001718
replaces: GO_0070128

methylene-fatty-acyl-phospholipid synthase activity
type: Class
subclass of: GO_0008757
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid.
has related synonym: cyclopropane synthetase activity
has related synonym: S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (methenylating)
has related synonym: unsaturated-phospholipid methyltransferase activity

mRNA (guanine-N7-)-methyltransferase activity
type: Class
subclass of: GO_0008170
subclass of: GO_0008174
subclass of: part-of-parent-6370
subclass of: part-of-parent-106005
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine.
has related synonym: guanine-7-methyltransferase activity
has related synonym: messenger ribonucleate guanine 7-methyltransferase activity
has related synonym: messenger RNA guanine 7-methyltransferase activity
has related synonym: S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity
has related synonym: S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity

mRNA (nucleoside-2'-O-)-methyltransferase activity
type: Class
subclass of: GO_0008171
subclass of: GO_0008174
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine.
has related synonym: messenger ribonucleate nucleoside 2'-methyltransferase activity
has related synonym: messenger RNA (nucleoside-2'-)-methyltransferase activity
has related synonym: mRNA (adenosine-2'-O-)-methyltransferase activity
has related synonym: S-adenosyl-L-methionine:mRNA (nucleoside-2'-O-)-methyltransferase activity

mRNA guanylyltransferase activity
type: Class
subclass of: GO_0008192
IAO_0000115: Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue.
has exact synonym: GTP:mRNA guanylyltransferase activity
has related synonym: GTP--RNA guanylyltransferase activity
has related synonym: messenger RNA guanylyltransferase activity
has related synonym: mRNA capping enzyme activity
has related synonym: protein lambda2

methylcrotonoyl-CoA carboxylase activity
type: Class
subclass of: GO_0016421
IAO_0000115: Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H(+) + phosphate.
has related synonym: 3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)
has related synonym: beta-methylcrotonyl CoA carboxylase activity
has related synonym: beta-methylcrotonyl-CoA carboxylase activity
has related synonym: beta-methylcrotonyl coenzyme A carboxylase activity
has exact synonym: MCCC activity
has related synonym: methylcrotonyl-CoA carboxylase activity
has related synonym: methylcrotonyl coenzyme A carboxylase activity

methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity
type: Class
subclass of: GO_0016646
IAO_0000115: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+.
has exact synonym: 5,10-methylene-THF dehydrogenase activity
has related synonym: N5,N10-methylenetetrahydrofolate dehydrogenase activity

methylenetetrahydrofolate dehydrogenase (NAD+) activity
type: Class
subclass of: methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity
IAO_0000115: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH.
has related synonym: 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase
has related synonym: 5,10-methylenetetrahydrofolate dehydrogenase activity

methylenetetrahydrofolate dehydrogenase (NADP+) activity
type: Class
subclass of: methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity
IAO_0000115: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH.
has related synonym: 5,10-methylenetetrahydrofolate:NADP+ oxidoreductase activity
has related synonym: 5,10-methylenetetrahydrofolate:NADP oxidoreductase activity

methylenetetrahydrofolate reductase (NAD(P)H) activity
type: Class
subclass of: GO_0016646
IAO_0000115: Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+.
has related synonym: 5,10-CH(2)-H(4)folate reductase activity
has related synonym: 5,10-CH2-H4folate reductase activity
has related synonym: 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity
has exact synonym: 5,10-methylenetetrahydrofolate reductase (FADH) activity
has exact synonym: 5,10-methylenetetrahydrofolate reductase (FADH2) activity
has related synonym: 5,10-methylenetetrahydrofolate reductase (NADPH) activity
has related synonym: 5,10-methylenetetrahydrofolate reductase activity
has related synonym: 5,10-methylenetetrahydrofolic acid reductase activity
has related synonym: 5,10-methylenetetrahydropteroylglutamate reductase activity
has related synonym: 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity
has related synonym: 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity
has related synonym: 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity
has related synonym: 5-methyltetrahydrofolate:NAD+ oxidoreductase activity
has related synonym: 5-methyltetrahydrofolate:NAD oxidoreductase activity
has related synonym: 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity
has related synonym: 5-methyltetrahydrofolate:NADP+ oxidoreductase activity
has related synonym: MetF
has related synonym: methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity
has related synonym: methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity
has related synonym: methylenetetrahydrofolate reductase (NADPH(2)) activity
has related synonym: methylenetetrahydrofolate reductase (NADPH2)
has related synonym: methylenetetrahydrofolate reductase [NAD(P)H]
has related synonym: methylenetetrahydrofolate reductase activity
has related synonym: methylenetetrahydrofolic acid reductase activity
has related synonym: MTHFR activity
has related synonym: N(5,10)-methylenetetrahydrofolate reductase activity
has related synonym: N(5),N(10)-methylenetetrahydrofolate reductase activity
has related synonym: N5,10-methylenetetrahydrofolate reductase activity
has related synonym: N5,N10-methylenetetrahydrofolate reductase activity
replaces: GO_0008702

methylglutaconyl-CoA hydratase activity
type: Class
subclass of: GO_0016836
IAO_0000115: Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H(2)O.
has related synonym: (S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming)
has related synonym: (S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase activity
has related synonym: 3-methylglutaconyl CoA hydratase activity
has related synonym: methylglutaconase activity
has related synonym: methylglutaconyl coenzyme A hydratase activity

methylmalonate-semialdehyde dehydrogenase (acylating) activity
type: Class
subclass of: GO_0016620
IAO_0000115: Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+.
has related synonym: 2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating)
has related synonym: MMSA dehydrogenase activity
has related synonym: MSDH activity

methylmalonyl-CoA decarboxylase activity
type: Class
subclass of: GO_0016831
IAO_0000115: Catalysis of the reaction: (S)-2-methyl-3-oxopropanoyl-CoA = propanoyl-CoA + CO2.
has related synonym: (S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase activity
has related synonym: (S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming)
has related synonym: (S)-methylmalonyl-CoA carboxy-lyase activity
has related synonym: methylmalonyl-coenzyme A decarboxylase activity

methylmalonyl-CoA epimerase activity
type: Class
subclass of: GO_0016854
IAO_0000115: Catalysis of the reaction: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA.
has related synonym: 2-methyl-3-oxopropanoyl-CoA 2-epimerase activity
has related synonym: DL-methylmalonyl-CoA racemase activity
has related synonym: methylmalonyl-CoA 2-epimerase activity
has related synonym: methylmalonyl-CoA racemase activity
has related synonym: methylmalonyl coenzyme A racemase activity

methylmalonyl-CoA mutase activity
type: Class
subclass of: GO_0016866
IAO_0000115: Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA.
has related synonym: (R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase activity
has related synonym: (R)-methylmalonyl-CoA CoA-carbonylmutase activity
has related synonym: (S)-methylmalonyl-CoA mutase activity
has related synonym: methylmalonyl-CoA CoA-carbonyl mutase activity
has related synonym: methylmalonyl coenzyme A carbonylmutase activity
has related synonym: methylmalonyl coenzyme A mutase activity

mevaldate reductase activity
type: Class
subclass of: GO_0016616
IAO_0000115: Catalysis of the reaction: (R)-mevalonate + acceptor = mevaldate + reduced acceptor.

mevalonate kinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016773
IAO_0000115: Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H(+).
has related synonym: ATP:(R)-mevalonate 5-phosphotransferase activity
has related synonym: ATP:mevalonate 5-phosphotransferase activity
has related synonym: mevalonate 5-phosphotransferase activity
has related synonym: mevalonate kinase (phosphorylating)
has related synonym: mevalonate phosphokinase activity
has related synonym: mevalonic acid kinase activity
has related synonym: mevalonic kinase activity
has related synonym: MVA kinase activity

monooxygenase activity
type: Class
subclass of: GO_0016491
IAO_0000115: Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
has related synonym: hydroxylase activity

calcidiol 1-monooxygenase activity
type: Class
subclass of: GO_0016709
subclass of: part-of-parent-36378
IAO_0000115: Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+).
has related synonym: 1-hydroxylase-25-hydroxyvitamin D3 activity
has related synonym: 25-hydroxycholecalciferol 1alpha-hydroxylase activity
has exact synonym: 25-hydroxycholecalciferol 1-hydroxylase activity
has related synonym: 25-hydroxycholecalciferol-1-hydroxylase activity
has related synonym: 25-hydroxycholecalciferol 1-monooxygenase activity
has related synonym: 25-hydroxy D3-1alpha-hydroxylase activity
has related synonym: 25-hydroxyvitamin D-1 alpha hydroxylase activity
has related synonym: 25-hydroxyvitamin D3 1alpha-hydroxylase activity
has exact synonym: 25-hydroxy vitamin D3 1-alpha-hydroxylase activity
has related synonym: 25-OHD-1 alpha-hydroxylase activity
has exact synonym: calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)
has related synonym: cytochrome P450 CYP27B

N,N-dimethylaniline monooxygenase activity
type: Class
subclass of: GO_0016709
IAO_0000115: Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.
has related synonym: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase activity
has exact synonym: dimethylaniline monooxygenase (N-oxide-forming) activity
has related synonym: dimethylaniline N-oxidase activity
has related synonym: dimethylaniline oxidase activity
has related synonym: DMA oxidase activity
has related synonym: FAD-containing monooxygenase activity
has related synonym: flavin-containing monooxygenase activity
has related synonym: flavin mixed function oxidase activity
has related synonym: flavin monooxygenase activity
has related synonym: FMO1
has related synonym: FMO2
has related synonym: FMO3
has related synonym: FMO4
has related synonym: FMO5
has related synonym: FMO activity
has related synonym: FMO-I
has related synonym: FMO-II
has exact synonym: methylphenyltetrahydropyridine N-monooxygenase activity
has related synonym: mixed-function amine oxidase activity
has related synonym: N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming)
has related synonym: Ziegler's enzyme
replaces: GO_0047076

dopamine beta-monooxygenase activity
type: Class
subclass of: GO_0016715
IAO_0000115: Catalysis of the reaction: L-ascorbate + dopamine + O(2) = (R)-noradrenaline + dehydroascorbate + H(2)O.
has related synonym: (3,4-dihydroxyphenethylamine)beta-mono-oxygenase activity
has related synonym: 3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
has related synonym: 3,4-dihydroxyphenethylamine beta-oxidase activity
has related synonym: 4-(2-aminoethyl)pyrocatechol beta-oxidase activity
has related synonym: dopa beta-hydroxylase activity
has related synonym: dopamine beta-hydroxylase activity
has related synonym: dopamine beta-oxidase activity
has exact synonym: dopamine b-hydroxylase activity
has related synonym: dopamine-B-hydroxylase activity
has related synonym: dopamine hydroxylase activity
has related synonym: MDBH (membrane-associated dopamine beta-monooxygenase)
has related synonym: oxygenase, dopamine beta-mono-
has related synonym: phenylamine beta-hydroxylase activity
has related synonym: SDBH (soluble dopamine beta-monooxygenase)

ecdysone 20-monooxygenase activity
type: Class
subclass of: GO_0008395
subclass of: GO_0016705
IAO_0000115: Catalysis of the reaction: AH(2) + Ecdysone + O(2) = 20-hydroxyecdysone + A + H(2)O.
has related synonym: alpha-ecdysone C-20 hydroxylase activity
has related synonym: ecdysone,hydrogen-donor:oxygen oxidoreductase (20-hydroxylating)
has exact synonym: ecdysone 20-hydroxylase activity
has related synonym: ecdysone modification

kynurenine 3-monooxygenase activity
type: Class
subclass of: GO_0016709
IAO_0000115: Catalysis of the reaction: L-kynurenine + H(+) + NADPH + O(2) = 3-hydroxy-L-kynurenine + H(2)O + NADP(+).
has exact synonym: kynurenine 3-hydroxylase activity
has related synonym: kynurenine hydroxylase activity
has related synonym: L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
has related synonym: L-kynurenine-3-hydroxylase activity

tyrosinase activity
type: Class
subclass of: GO_0016716
IAO_0000115: Catalysis of the reaction: L-tyrosine + O2 = L-DOPAquinone + H2O. This reaction can use both monophenols (such as tyrosine) and catechols (o-diphenols) as substrates.
has related synonym: catecholase
has related synonym: chlorogenic acid oxidase activity
has related synonym: chlorogenic oxidase activity
has related synonym: cresolase activity
has related synonym: dopa oxidase
has exact synonym: L-tyrosine monooxygenase activity
has related synonym: monophenolase activity
has related synonym: monophenol monooxidase activity
has exact synonym: monophenol monooxygenase activity
has related synonym: monophenol oxidase activity
has exact synonym: monophenol oxygenase
has related synonym: N-acetyl-6-hydroxytryptophan oxidase activity
has related synonym: o-diphenol:O2 oxidoreductase activity
has related synonym: o-diphenol oxidase activity
has related synonym: o-diphenol oxidoreductase
has related synonym: phenolase activity
has related synonym: phenol oxidase activity
has related synonym: prophenoloxidase activity
has related synonym: prophenol oxidase activity
has related synonym: pyrocatechol oxidase
has related synonym: tyrosine-dopa oxidase activity

peptidylglycine monooxygenase activity
type: Class
subclass of: GO_0016715
IAO_0000115: Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O.
has related synonym: PAM-A
has related synonym: PAM activity
has related synonym: PAM-B
has related synonym: peptide alpha-amidating enzyme
has related synonym: peptide alpha-amide synthase activity
has related synonym: peptide-alpha-amide synthetase activity
has related synonym: peptidyl alpha-amidating enzyme activity
has related synonym: peptidylglycine,ascorbate:oxygen oxidoreductase (2-hydroxylating)
has exact synonym: peptidylglycine 2-hydroxylase activity
has related synonym: peptidylglycine alpha-amidating monooxygenase activity
has related synonym: peptidylglycine alpha-hydroxylase activity
has related synonym: synthase, peptide alpha-amide

phenylalanine 4-monooxygenase activity
type: Class
subclass of: GO_0016714
subclass of: part-of-parent-19293
IAO_0000115: Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin.
has related synonym: L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
has related synonym: PAH activity
has related synonym: phenylalaninase activity
has related synonym: phenylalanine 4-hydroxylase activity
has exact synonym: phenylalanine hydroxylase activity

squalene monooxygenase activity
type: Class
subclass of: GO_0016709
IAO_0000115: Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+).
has exact synonym: squalene,NADPH:oxygen oxidoreductase (2,3-epoxidizing) activity
has related synonym: squalene-2,3-epoxidase activity
has related synonym: squalene-2,3-epoxide cyclase activity
has related synonym: squalene 2,3-oxidocyclase activity
has related synonym: squalene epoxidase activity
has related synonym: squalene hydroxylase activity
has related synonym: squalene oxydocyclase activity

steroid 11-beta-monooxygenase activity
type: Class
subclass of: GO_0008395
subclass of: GO_0016713
IAO_0000115: Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O.
has related synonym: cytochrome P450 CYP11B1
has related synonym: cytochrome P450 CYP11B2
has related synonym: cytochrome p450 XIB1 activity
has related synonym: oxygenase, steroid 11beta -mono-
has related synonym: steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)
has related synonym: steroid 11beta/18-hydroxylase activity
has related synonym: steroid 11-beta/18-hydroxylase activity
has related synonym: steroid 11beta-hydroxylase activity
has exact synonym: steroid 11-beta-hydroxylase activity
has related synonym: steroid 11beta-monooxygenase activity

steroid 17-alpha-monooxygenase activity
type: Class
subclass of: GO_0008395
subclass of: GO_0016705
IAO_0000115: Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O.
has related synonym: 17alpha-hydroxylase-C17,20 lyase activity
has related synonym: cytochrome P-450 (P-45017alpha,lyase)
has related synonym: cytochrome P45017alpha
has related synonym: cytochrome P450 CYP17
has related synonym: cytochrome p450 XVIIA1 activity
has related synonym: steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)
has related synonym: steroid 17alphahydroxylase/17,20 lyase activity
has related synonym: steroid 17-alpha-hydroxylase/17,20 lyase activity
has related synonym: steroid 17alpha-hydroxylase activity
has exact synonym: steroid 17-alpha-hydroxylase activity
has exact synonym: steroid 17-alpha-hydroxylase-C17-20 lyase activity
has related synonym: steroid 17alpha-monooxygenase activity

steroid 21-monooxygenase activity
type: Class
subclass of: GO_0008395
subclass of: GO_0016705
IAO_0000115: Catalysis of the reaction: A C(21) steroid + [reduced NADPH--hemoprotein reductase] + O(2) = a 21-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H(2)O.
has related synonym: 21-hydroxylase activity
has related synonym: cytochrome P450 CYP21A1
has related synonym: cytochrome p450 XXIA1 activity
has related synonym: steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating)
has exact synonym: steroid 21-hydroxylase activity

tryptophan 5-monooxygenase activity
type: Class
subclass of: GO_0016714
IAO_0000115: Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O.
has related synonym: indoleacetic acid-5-hydroxylase activity
has related synonym: L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
has exact synonym: L-tryptophan hydroxylase activity
has related synonym: tryptophan 5-hydroxylase activity
has related synonym: tryptophan hydroxylase activity

tyrosine 3-monooxygenase activity
type: Class
subclass of: GO_0016714
IAO_0000115: Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O.
has related synonym: L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)
has related synonym: L-tyrosine hydroxylase activity
has exact synonym: tyrosine 3-hydroxylase activity
has exact synonym: tyrosine hydroxylase activity

inositol-3-phosphate synthase activity
type: Class
subclass of: GO_0016872
IAO_0000115: Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form.
has related synonym: 1L-myo-inositol-1-phosphate lyase (isomerizing)
has related synonym: D-glucose 6-phosphate cycloaldolase activity
has related synonym: glucocycloaldolase activity
has related synonym: glucose 6-phosphate cyclase activity
has related synonym: glucose-6-phosphate inositol monophosphate cycloaldolase activity
has related synonym: inositol 1-phosphate synthatase activity
has related synonym: inositol 1-phosphate synthetase activity

neolactotetraosylceramide alpha-2,3-sialyltransferase activity
type: Class
subclass of: GO_0008373
IAO_0000115: Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide.
has related synonym: CMP-N-acetylneuraminate:neolactotetraosylceramide alpha-2,3-sialyltransferase activity
has related synonym: cytidine monophosphoacetylneuraminate-neolactotetraosylceramide sialyltransferase activity
has related synonym: SAT-3
has related synonym: sialyltransferase 3

nicotinate-nucleotide diphosphorylase (carboxylating) activity
type: Class
subclass of: GO_0016763
IAO_0000115: Catalysis of the reaction: CO(2) + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate.
has related synonym: NAD pyrophosphorylase activity
has related synonym: nicotinate mononucleotide pyrophosphorylase (carboxylating)
has related synonym: nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating)
has exact synonym: nicotinate-nucleotide pyrophosphorylase (carboxylating) activity
has related synonym: QAPRTase activity
has related synonym: quinolinate phosphoribosyltransferase (decarboxylating) activity
has related synonym: quinolinic acid phosphoribosyltransferase activity
has related synonym: quinolinic phosphoribosyltransferase activity

nicotinate-nucleotide adenylyltransferase activity
type: Class
subclass of: GO_0070566
IAO_0000115: Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+.
has exact synonym: ATP:nicotinate-nucleotide adenylyltransferase activity
has related synonym: ATP:nicotinate-ribonucleotide adenylyltransferase activity
has related synonym: deamido-NAD(+) diphosphorylase activity
has related synonym: deamido-NAD(+) pyrophosphorylase activity
has related synonym: deamido-NAD+ pyrophosphorylase activity
has related synonym: deamidonicotinamide adenine dinucleotide pyrophosphorylase activity
has related synonym: NaMN-ATase activity
has related synonym: nicotinate mononucleotide adenylyltransferase activity
has related synonym: nicotinic acid mononucleotide adenylyltransferase

nicotinate phosphoribosyltransferase activity
type: Class
subclass of: GO_0016879
IAO_0000115: Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate.
has related synonym: niacin ribonucleotidase activity
has related synonym: nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity
has related synonym: nicotinic acid mononucleotide glycohydrolase activity
has related synonym: nicotinic acid mononucleotide pyrophosphorylase activity
has related synonym: nicotinic acid phosphoribosyltransferase activity

nitric-oxide synthase activity
type: Class
subclass of: GO_0016709
IAO_0000115: Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+.
has related synonym: endothelium-derived relaxation factor-forming enzyme activity
has related synonym: endothelium-derived relaxing factor synthase activity
has related synonym: L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity
has related synonym: NADPH-diaphorase activity
has exact synonym: nitric oxide synthase activity
has related synonym: nitric oxide synthetase activity
has related synonym: nitric-oxide synthetase activity
has related synonym: NO synthase activity

nuclease activity
type: Class
subclass of: GO_0016788
subclass of: part-of-parent-90305
IAO_0000115: Catalysis of the hydrolysis of ester linkages within nucleic acids.

endonuclease activity
type: Class
subclass of: nuclease activity
IAO_0000115: Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.

endodeoxyribonuclease activity
type: Class
subclass of: endonuclease activity
subclass of: deoxyribonuclease activity
IAO_0000115: Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.
has related synonym: DNA nicking activity
has related synonym: endonuclease G activity

endoribonuclease activity
type: Class
subclass of: endonuclease activity
subclass of: ribonuclease activity
subclass of: part-of-parent-90502
IAO_0000115: Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
has related synonym: endonuclease G activity

ribonuclease A activity
type: Class
subclass of: GO_0016892
IAO_0000115: Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates.
has exact synonym: alkaline ribonuclease activity
has exact synonym: ceratitis capitata alkaline ribonuclease activity
has related synonym: endoribonuclease I
has related synonym: gene S glycoproteins
has related synonym: gene S locus-specific glycoproteins
has related synonym: pancreatic ribonuclease activity
has related synonym: pancreatic RNase activity
has related synonym: ribonuclease I activity
has exact synonym: ribonucleate 3'-pyrimidino-oligonucleotidohydrolase activity
has exact synonym: ribonucleic phosphatase activity
has related synonym: RNase A activity
has related synonym: RNase activity
has related synonym: RNase I activity
has related synonym: S-genotype-assocd. glycoproteins
has related synonym: SLSG glycoproteins

RNA-DNA hybrid ribonuclease activity
type: Class
subclass of: GO_0016891
IAO_0000115: Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.
has exact synonym: calf thymus ribonuclease H activity
has related synonym: endoribonuclease0 H activity
has related synonym: endoribonuclease H
has related synonym: endoribonuclease H (calf thymus)
has related synonym: hybridase (ribonuclease H)
has related synonym: hybridase activity
has related synonym: hybrid nuclease activity
has related synonym: hybrid ribonuclease activity
has related synonym: ribonuclease H1 activity
has related synonym: ribonuclease H2 activity
has related synonym: ribonuclease H3 activity
has exact synonym: ribonuclease H activity
has related synonym: RNA*DNA hybrid ribonucleotidohydrolase activity
has related synonym: RNase H1 activity
has related synonym: RNase H2 activity
has related synonym: RNase H3 activity
has exact synonym: RNase H activity
replaces: GO_0004524

ribonuclease III activity
type: Class
subclass of: GO_0016891
subclass of: GO_0032296
IAO_0000115: Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.
has related synonym: pre-mRNA 3'-end processing endonuclease
has related synonym: ribonuclease 3 activity
has related synonym: RNase III activity

ribonuclease P activity
type: Class
subclass of: tRNA-specific ribonuclease activity
subclass of: GO_0016891
IAO_0000115: Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor.
has exact synonym: RNase P
has exact synonym: tRNA 5' leader endonuclease activity

exonuclease activity
type: Class
subclass of: nuclease activity
IAO_0000115: Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.
has related synonym: exonuclease IX activity
replaces: GO_0008857

phosphodiesterase I activity
type: Class
subclass of: exonuclease activity
subclass of: GO_0008081
IAO_0000115: Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.
has related synonym: 5'-exonuclease activity
has related synonym: 5'-NPDase activity
has related synonym: 5'NPDE activity
has related synonym: 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity
has related synonym: 5'-nucleotide phosphodiesterase activity
has related synonym: 5'-PDase activity
has related synonym: 5'-PDE activity
has related synonym: 5'-phosphodiesterase activity
has related synonym: alkaline phosphodiesterase activity
has related synonym: exonuclease I activity
has related synonym: nucleotide pyrophosphatase/phosphodiesterase I activity
has related synonym: oligonucleate 5'-nucleotidohydrolase activity
has related synonym: orthophosphoric diester phosphohydrolase activity
has related synonym: PDE I activity
has related synonym: phosphodiesterase activity

exodeoxyribonuclease activity
type: Class
subclass of: exonuclease activity
subclass of: deoxyribonuclease activity
IAO_0000115: Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule.

deoxyribonuclease I activity
type: Class
subclass of: GO_0016888
IAO_0000115: Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products.
has related synonym: alkaline deoxyribonuclease activity
has related synonym: alkaline DNase activity
has related synonym: deoxyribonuclease (pancreatic)
has related synonym: deoxyribonuclease A
has related synonym: deoxyribonucleic phosphatase activity
has related synonym: DNAase activity
has related synonym: DNA depolymerase activity
has related synonym: DNA endonuclease activity
has related synonym: DNA nuclease activity
has related synonym: DNase activity
has related synonym: DNase I
has related synonym: dornava
has related synonym: dornavac
has related synonym: endodeoxyribonuclease I
has related synonym: Escherichia coli endonuclease I
has related synonym: pancreatic deoxyribonuclease
has related synonym: pancreatic DNase activity
has related synonym: pancreatic dornase
has related synonym: thymonuclease, dornase activity
has related synonym: thymonuclease activity

deoxyribonuclease II activity
type: Class
subclass of: GO_0016889
IAO_0000115: Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products.
has related synonym: acid deoxyribonuclease activity
has related synonym: acid DNase activity
has related synonym: deoxyribonucleate 3'-nucleotidohydrolase activity
has related synonym: DNase II activity
has related synonym: lysosomal DNase II activity
has related synonym: pancreatic DNase II

exoribonuclease activity
type: Class
subclass of: exonuclease activity
subclass of: ribonuclease activity
subclass of: part-of-parent-90503
IAO_0000115: Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule.

exoribonuclease H activity
type: Class
subclass of: GO_0016896
IAO_0000115: Catalysis of the exonucleolytic cleavage of RNA to 5'-phosphomonoester oligonucleotides in both 5' to 3' and 3' to 5' directions.
has related synonym: retroviral reverse transcriptase RNaseH

5'-3' exoribonuclease activity
type: Class
subclass of: GO_0008409
subclass of: GO_0016896
IAO_0000115: Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule.

poly(A)-specific ribonuclease activity
type: Class
subclass of: 3'-5'-exoribonuclease activity
IAO_0000115: Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.
has related synonym: 2',3'-exoribonuclease activity
has related synonym: 3'-exoribonuclease activity
has exact synonym: poly(A)-specific RNase activity

deoxyribonuclease activity
type: Class
subclass of: nuclease activity
subclass of: GO_0140097
subclass of: part-of-parent-6259
IAO_0000115: Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid.
has related synonym: caspase-activated deoxyribonuclease activity
replaces: GO_0004537

ribonuclease activity
type: Class
subclass of: nuclease activity
subclass of: GO_0140098
subclass of: part-of-parent-90501
IAO_0000115: Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.

tRNA-specific ribonuclease activity
type: Class
subclass of: ribonuclease activity
subclass of: GO_0140101
IAO_0000115: Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules.
has exact synonym: tRNA-specific RNase activity

nucleoside diphosphate kinase activity
type: Class
subclass of: GO_0016776
subclass of: GO_0019205
IAO_0000115: Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
has related synonym: ATP:nucleoside-diphosphate phosphotransferase activity
has related synonym: NDK activity
has related synonym: nucleoside 5'-diphosphate kinase activity
has related synonym: nucleoside 5'-diphosphate phosphotransferase activity
has related synonym: nucleoside diphosphate (UDP) kinase activity
has exact synonym: nucleoside-diphosphate kinase activity
has related synonym: nucleoside diphosphokinase activity
has related synonym: nucleotide phosphate kinase activity
has related synonym: UDP kinase activity
has related synonym: uridine diphosphate kinase activity

dinucleotide phosphatase activity
type: Class
subclass of: GO_0016462
IAO_0000115: Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides.
has related synonym: dinucleotide nucleotidohydrolase activity
has related synonym: nucleotide diphosphatase activity
has exact synonym: nucleotide pyrophosphatase activity

octanol dehydrogenase activity
type: Class
subclass of: GO_0016616
IAO_0000115: Catalysis of the reaction: 1-octanol + NAD(+) = 1-octanal + H(+) + NADH.
has related synonym: 1-octanol dehydrogenase activity
has related synonym: octanol:NAD+ oxidoreductase activity

hydrolase activity, hydrolyzing O-glycosyl compounds
type: Class
subclass of: GO_0016798
IAO_0000115: Catalysis of the hydrolysis of any O-glycosyl bond.
has exact synonym: O-glucosyl hydrolase activity
replaces: GO_0016800

alpha,alpha-trehalase activity
type: Class
subclass of: GO_0015927
IAO_0000115: Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose.
has related synonym: alpha,alpha-trehalose glucohydrolase activity

alpha-amylase activity
type: Class
subclass of: GO_0016160
IAO_0000115: Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units.
has related synonym: 1,4-alpha-D-glucan glucanohydrolase activity
has related synonym: alpha amylase activity
has related synonym: alpha-amylase activity (releasing maltohexaose)
has related synonym: endoamylase activity
has related synonym: glycogenase activity
has related synonym: taka-amylase A
replaces: GO_0103025

alpha-galactosidase activity
type: Class
subclass of: GO_0015925
IAO_0000115: Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactohydrolase.
has related synonym: alpha-D-galactosidase activity
has related synonym: alpha-D-galactoside galactohydrolase activity
has related synonym: alpha-galactosidase A
has related synonym: alpha-galactoside galactohydrolase activity
has exact synonym: melibiase activity

alpha-1,4-glucosidase activity
type: Class
subclass of: GO_0090599
IAO_0000115: Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.
has related synonym: acid maltase activity
has related synonym: alpha-D-glucosidase activity
has related synonym: alpha-D-glucoside glucohydrolase activity
has related synonym: alpha-glucopyranosidase activity
has related synonym: alpha-glucosidase II
has related synonym: alpha-glucoside hydrolase activity
has related synonym: glucoinvertase activity
has related synonym: glucosidoinvertase activity
has related synonym: glucosidosucrase activity
has related synonym: lysosomal alpha-glucosidase activity
has related synonym: maltase-glucoamylase activity
replaces: GO_0004562
replaces: GO_0016982

alpha-mannosidase activity
type: Class
subclass of: GO_0015923
IAO_0000115: Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.
has related synonym: 1,2-alpha-D-mannosidase activity
has related synonym: 1,2-alpha-mannosidase
has related synonym: alpha-D-mannopyranosidase activity
has related synonym: alpha-D-mannosidase activity
has related synonym: alpha-D-mannoside mannohydrolase activity
has related synonym: exo-alpha-mannosidase activity
has related synonym: p-nitrophenyl-alpha-mannosidase activity

alpha-L-fucosidase activity
type: Class
subclass of: GO_0015928
IAO_0000115: Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose.
has related synonym: alpha-fucosidase activity
has related synonym: alpha-L-fucoside fucohydrolase activity

alpha-N-acetylglucosaminidase activity
type: Class
subclass of: GO_0015929
IAO_0000115: Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides.
has related synonym: alpha-acetylglucosaminidase activity
has related synonym: alpha-D-2-acetamido-2-deoxyglucosidase activity
has related synonym: alpha-N-acetyl-D-glucosaminide N-acetylglucosaminohydrolase activity
has related synonym: N-acetyl-alpha-D-glucosaminidase activity
has related synonym: N-acetyl-alpha-glucosaminidase activity
has related synonym: NAG activity

beta-N-acetylhexosaminidase activity
type: Class
subclass of: GO_0015929
IAO_0000115: Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.
has related synonym: beta-acetylaminodeoxyhexosidase activity
has related synonym: beta-acetylhexosaminidinase activity
has related synonym: beta-D-hexosaminidase activity
has related synonym: beta-D-N-acetylhexosaminidase activity
has related synonym: beta-hexosaminidase activity
has related synonym: beta-N-acetyl-D-hexosaminidase activity
has related synonym: beta-N-acetyl-D-hexosaminide N-acetylhexosaminohydrolase activity
has related synonym: hexosaminidase A
has related synonym: N-acetyl-beta-D-hexosaminidase activity
has related synonym: N-acetyl-beta-glucosaminidase activity
has related synonym: N-acetyl-beta-hexosaminidase activity
has related synonym: N-acetylhexosaminidase activity

beta-fructofuranosidase activity
type: Class
subclass of: hydrolase activity, hydrolyzing O-glycosyl compounds
IAO_0000115: Catalysis of the reaction: a fructofuranosylated fructofuranosyl acceptor + H2O = a non fructofuranosylated fructofuranosyl acceptor + a beta-D-fructofuranoside.
has related synonym: acid invertase activity
has related synonym: alkaline invertase activity
has exact synonym: beta-D-fructofuranoside fructohydrolase activity
has related synonym: beta-fructosidase activity
has related synonym: beta-h-fructosidase activity
has related synonym: fructosylinvertase activity
has related synonym: glucosucrase activity
has related synonym: invertase activity
has related synonym: invertin activity
has related synonym: maxinvert L 1000 activity
has related synonym: saccharase activity

beta-galactosidase activity
type: Class
subclass of: GO_0015925
IAO_0000115: Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides.
has related synonym: beta-D-galactanase activity
has related synonym: beta-D-galactoside galactohydrolase activity
has related synonym: beta-D-lactosidase activity
has related synonym: beta-lactosidase activity
has related synonym: exo-(1->4)-beta-D-galactanase activity
has related synonym: hydrolact

beta-glucuronidase activity
type: Class
subclass of: hydrolase activity, hydrolyzing O-glycosyl compounds
IAO_0000115: Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate.
has related synonym: beta-D-glucuronoside glucuronosohydrolase activity
has related synonym: beta-glucuronide glucuronohydrolase activity
has related synonym: exo-beta-D-glucuronidase activity
has related synonym: glucuronidase activity
has related synonym: ketodase activity

beta-mannosidase activity
type: Class
subclass of: GO_0015923
IAO_0000115: Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.
has related synonym: beta-D-mannosidase activity
has related synonym: beta-D-mannoside mannohydrolase activity
has related synonym: beta-mannoside mannohydrolase activity
has related synonym: exo-beta-D-mannanase activity
has related synonym: mannanase activity
has related synonym: mannase activity

chitinase activity
type: Class
subclass of: hydrolase activity, hydrolyzing O-glycosyl compounds
IAO_0000115: Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins.
has related synonym: 1,4-beta-poly-N-acetylglucosaminidase activity
has related synonym: beta-1,4-poly-N-acetyl glucosamidinase activity
has related synonym: chitodextrinase activity
has related synonym: poly[1,4-(N-acetyl-beta-D-glucosaminide)] glycanohydrolase activity
has related synonym: poly-beta-glucosaminidase activity

glycoprotein endo-alpha-1,2-mannosidase activity
type: Class
subclass of: alpha-mannosidase activity
IAO_0000115: Catalysis of the hydrolysis of the terminal alpha-glucosyl-(1,3)-mannosyl unit from Glc-Man(9)-(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane.
has related synonym: endo-alpha-mannosidase activity
has related synonym: endomannosidase activity
has related synonym: glucosylmannosidase activity
has related synonym: glucosyl mannosidase activity
has related synonym: glycoprotein glucosylmannohydrolase activity

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
type: Class
subclass of: GO_0015924
IAO_0000115: Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide.
has related synonym: 1,2-alpha-mannosidase
has related synonym: 1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity
has related synonym: exo-alpha-1,2-mannanase activity
has related synonym: glycoprotein processing mannosidase I
has related synonym: Man9-mannosidase activity
has related synonym: ManI activity
has related synonym: mannose-9 processing alpha-mannosidase activity
has related synonym: mannosidase 1A activity
has related synonym: mannosidase 1B activity
has related synonym: mannosidase I

mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
type: Class
subclass of: GO_0015924
IAO_0000115: Catalysis of the hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3).
has related synonym: 1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase activity
has related synonym: alpha-(1,3/6)-mannosidase activity
has related synonym: alpha-D-mannosidase II
has related synonym: alpha-mannosidase II
has related synonym: exo-1,3-1,6-alpha-mannosidase activity
has related synonym: GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase activity
has related synonym: Golgi alpha-mannosidase II
has related synonym: ManII activity
has related synonym: mannosidase II activity
has exact synonym: mannosyl-oligosaccharide (1->3,6)-alpha-mannosidase activity
has exact synonym: mannosyl-oligosaccharide (1->3/6)-alpha-mannosidase activity
has exact synonym: mannosyl-oligosaccharide (1->3)-(1->6)-alpha-mannosidase activity

Glc3Man9GlcNAc2 oligosaccharide glucosidase activity
type: Class
subclass of: GO_0015926
IAO_0000115: Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2).
has related synonym: mannosyl-oligosaccharide glucohydrolase activity
has exact synonym: mannosyl-oligosaccharide glucosidase (processing A-glucosidase I) activity
has related synonym: mannosyl-oligosaccharide glucosidase activity
has related synonym: processing A-glucosidase I activity
has exact synonym: trimming glucosidase I

oligo-1,6-glucosidase activity
type: Class
subclass of: GO_0090599
IAO_0000115: Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. Releases a free alpha-D-glucose.
has related synonym: alpha-limit dextrinase activity
has related synonym: alpha-methylglucosidase activity
has related synonym: dextrin 6alpha-glucanohydrolase activity
has related synonym: dextrin 6-glucanohydrolase activity
has related synonym: exo-oligo-1,6-glucosidase activity
has related synonym: isomaltase activity
has related synonym: limit dextrinase
has related synonym: oligosaccharide alpha-1,6-glucohydrolase activity
has related synonym: oligosaccharide alpha-1,6-glucosidase activity
has related synonym: sucrase-isomaltase activity

sucrose alpha-glucosidase activity
type: Class
subclass of: beta-fructofuranosidase activity
subclass of: GO_0090599
IAO_0000115: Catalysis of the reaction: sucrose + H2O = alpha-D-glucose + beta-D-fructose.
has related synonym: alpha-D-glucopyranosyl beta-D-fructofuranoside hydrolysis
has related synonym: beta-D-fructofuranosyl alpha-D-glucopyranoside hydrolysis
has related synonym: intestinal sucrase activity
has related synonym: sucrase(invertase)
has related synonym: sucrase activity
has related synonym: sucrase-isomaltase activity
has exact synonym: sucrose alpha-D-glucohydrolase activity
has related synonym: sucrose-alpha-D-glucohydrolase activity
has related synonym: sucrose alpha-glucohydrolase activity
has related synonym: sucrose hydrolysis

oligosaccharyl transferase activity
type: Class
subclass of: GO_0016758
IAO_0000115: Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid.
has exact synonym: oligosaccharide transferase activity

N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity
type: Class
subclass of: GO_0008375
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol.
has related synonym: N,N'-diacetylchitobiosylpyrophosphoryldolichol synthase activity
has related synonym: UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase activity
has related synonym: UDP-N-acetyl-D-glucosamine:N-acetyl-D-glucosaminyl-diphosphodolichol N-acetyl-D-glucosaminyltransferase activity
has related synonym: uridine diphosphoacetylglucosamine-dolichylacetylglucosamine pyrophosphate acetylglucosaminyltransferase activity

chitobiosyldiphosphodolichol beta-mannosyltransferase activity
type: Class
subclass of: GO_0019187
IAO_0000115: Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol.
has related synonym: GDP-mannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase activity
has related synonym: GDP-mannose-dolichol diphosphochitobiose mannosyltransferase activity
has related synonym: guanosine diphosphomannose-dolichol diphosphochitobiose mannosyltransferase activity

dolichyl-diphosphooligosaccharide-protein glycotransferase activity
type: Class
subclass of: oligosaccharyl transferase activity
IAO_0000115: Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine.
has exact synonym: asparagine N-glycosyltransferase activity
has exact synonym: dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase activity
has exact synonym: dolichyldiphosphooligosaccharide-protein glycosyltransferase activity
has exact synonym: dolichyl-diphosphooligosaccharide-protein glycosyltransferase activity
has exact synonym: dolichyldiphosphooligosaccharide-protein oligosaccharyltransferase activity
has exact synonym: dolichyldiphosphoryloligosaccharide-protein oligosaccharyltransferase activity
has exact synonym: dolichylpyrophosphodiacetylchitobiose-protein glycosyltransferase activity
has related synonym: oligomannosyltransferase activity

dolichyl-phosphate beta-glucosyltransferase activity
type: Class
subclass of: GO_0035251
IAO_0000115: Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate.
has related synonym: polyprenyl phosphate:UDP-D-glucose glucosyltransferase activity
has related synonym: UDP-glucose:dolichol phosphate glucosyltransferase activity
has related synonym: UDP-glucose:dolicholphosphoryl glucosyltransferase activity
has related synonym: UDP-glucose:dolichyl monophosphate glucosyltransferase activity
has related synonym: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase activity
has related synonym: UDP-glucose:dolichyl-phosphate beta-D-glucosyltransferase activity
has related synonym: UDP-glucose:dolichyl phosphate glucosyltransferase activity
has related synonym: UDP-glucose dolichyl-phosphate glucosyltransferase activity
has related synonym: uridine diphosphoglucose-dolichol glucosyltransferase activity

dolichyl-phosphate beta-D-mannosyltransferase activity
type: Class
subclass of: mannosyltransferase activity
IAO_0000115: Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate.
has related synonym: dolichol phosphate mannose synthase activity
has related synonym: dolichol-phosphate mannose synthase activity
has exact synonym: dolichol-phosphate-mannose synthase activity
has related synonym: dolichol-phosphate mannosyltransferase activity
has related synonym: dolichyl mannosyl phosphate synthase activity
has related synonym: dolichyl-phosphate mannose synthase activity
has related synonym: dolichyl phosphate mannosyltransferase activity
has related synonym: dolichyl-phospho-mannose synthase activity
has exact synonym: DPM synthase activity
has related synonym: GDPMan:DolP mannosyltransferase activity
has related synonym: GDP-mannose:dolichyl-phosphate beta-D-mannosyltransferase activity
has related synonym: GDPmannose:dolichyl-phosphate mannosyltransferase activity
has related synonym: GDP-mannose-dolichol phosphate mannosyltransferase activity
has related synonym: GDPmannose-dolichylmonophosphate mannosyltransferase activity
has related synonym: guanosine diphosphomannose-dolichol phosphate mannosyltransferase activity
has related synonym: mannosylphosphodolichol synthase activity
has related synonym: mannosylphosphoryldolichol synthase activity

dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity
type: Class
subclass of: GO_0046527
IAO_0000115: Catalysis of the transfer of an alpha-D-glucosyl residue from dolichyl-phosphate D-glucose into a membrane lipid-linked oligosaccharide.

obsolete dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the transfer of an alpha-D-mannosyl residue from dolichyl-phosphate D-mannose into membrane lipid-linked oligosaccharide.

ornithine carbamoyltransferase activity
type: Class
subclass of: GO_0016743
subclass of: part-of-parent-6591
IAO_0000115: Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.
has related synonym: carbamoyl-phosphate:L-ornithine carbamoyltransferase activity
has related synonym: carbamylphosphate-ornithine transcarbamylase activity
has related synonym: citrulline phosphorylase activity
has related synonym: L-ornithine carbamoyltransferase activity
has related synonym: L-ornithine carbamyltransferase activity
has related synonym: L-ornithine transcarbamylase activity
has related synonym: ornithine carbamyltransferase activity
has related synonym: ornithine transcarbamylase activity
has related synonym: OTC activity
has related synonym: OTCase activity

ornithine decarboxylase activity
type: Class
subclass of: GO_0016831
IAO_0000115: Catalysis of the reaction: L-ornithine + H(+) = CO(2) + putrescine.
has related synonym: L-ornithine carboxy-lyase (putrescine-forming)
has related synonym: L-ornithine carboxy-lyase activity
has related synonym: SpeC

ornithine-oxo-acid transaminase activity
type: Class
subclass of: GO_0008483
IAO_0000115: Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.
has related synonym: GabT
has related synonym: L-ornithine:2-oxo-acid aminotransferase activity
has related synonym: L-ornithine:alpha-ketoglutarate delta-aminotransferase activity
has related synonym: L-ornithine 5-aminotransferase activity
has related synonym: L-ornithine aminotransferase activity
has related synonym: OAT
has related synonym: ornithine:alpha-oxoglutarate transaminase activity
has related synonym: ornithine--2-oxoacid aminotransferase activity
has related synonym: ornithine 5-aminotransferase activity
has related synonym: ornithine--alpha-ketoglutarate aminotransferase activity
has related synonym: ornithine aminotransferase activity
has related synonym: ornithine delta-transaminase activity
has related synonym: ornithine ketoacid aminotransferase activity
has related synonym: ornithine--keto acid aminotransferase activity
has related synonym: ornithine--keto acid transaminase activity
has related synonym: ornithine--ketoglutarate aminotransferase activity
has exact synonym: ornithine-oxo-acid aminotransferase activity
has related synonym: ornithine--oxo acid aminotransferase activity
has related synonym: ornithine--oxo-acid transaminase activity
has related synonym: ornithine transaminase activity

orotate phosphoribosyltransferase activity
type: Class
subclass of: GO_0016763
IAO_0000115: Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.
has related synonym: OPRT activity
has related synonym: OPRTase activity
has related synonym: orotate phosphoribosyl pyrophosphate transferase activity
has related synonym: orotic acid phosphoribosyltransferase activity
has related synonym: orotidine 5'-monophosphate pyrophosphorylase activity
has related synonym: orotidine-5'-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase activity
has related synonym: orotidine-5'-phosphate diphosphorylase activity
has related synonym: orotidine-5'-phosphate pyrophosphorylase activity
has related synonym: orotidine monophosphate pyrophosphorylase activity
has related synonym: orotidine phosphoribosyltransferase activity
has related synonym: orotidylate phosphoribosyltransferase activity
has related synonym: orotidylate pyrophosphorylase activity
has related synonym: orotidylic acid phosphorylase activity
has related synonym: orotidylic acid pyrophosphorylase activity
has related synonym: orotidylic phosphorylase activity
has related synonym: orotidylic pyrophosphorylase activity

orotate reductase (NADH) activity
type: Class
subclass of: GO_0016628
IAO_0000115: Catalysis of the reaction: (S)-dihydroorotate + NAD(+) = H(+) + NADH + orotate.
has related synonym: (S)-dihydroorotate:NAD+ oxidoreductase activity

orotidine-5'-phosphate decarboxylase activity
type: Class
subclass of: GO_0016831
IAO_0000115: Catalysis of the reaction: H(+) + orotidine 5'-phosphate = CO(2) + UMP.
has related synonym: ODCase activity
has related synonym: OMP-DC
has related synonym: OMPdcase activity
has related synonym: OMP decarboxylase activity
has related synonym: orotate decarboxylase activity
has related synonym: orotate monophosphate decarboxylase activity
has related synonym: orotic decarboxylase activity
has related synonym: orotidine-5'-monophosphate decarboxylase activity
has related synonym: orotidine-5'-phosphate carboxy-lyase (UMP-forming)
has related synonym: orotidine-5'-phosphate carboxy-lyase activity
has related synonym: orotidine 5'-phosphate decarboxylase activity
has related synonym: orotidine monophosphate decarboxylase activity
has related synonym: orotidine phosphate decarboxylase activity
has related synonym: orotidylic acid decarboxylase activity
has related synonym: orotidylic decarboxylase activity
has related synonym: orotodylate decarboxylase activity
has related synonym: UMP synthase activity
has related synonym: uridine 5'-monophosphate synthase activity

oxoglutarate dehydrogenase (succinyl-transferring) activity
type: Class
subclass of: GO_0016624
IAO_0000115: Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2.
has related synonym: 2-ketoglutarate dehydrogenase activity
has related synonym: 2-oxoglutarate:dihydrolipoyllysine-residue succinyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating)
has related synonym: 2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating) activity
has related synonym: 2-oxoglutarate: lipoate oxidoreductase activity
has related synonym: 2-oxoglutarate dehydrogenase activity
has related synonym: AKGDH activity
has related synonym: alpha-ketoglutarate dehydrogenase activity
has related synonym: alpha-ketoglutaric acid dehydrogenase activity
has related synonym: alpha-ketoglutaric dehydrogenase activity
has related synonym: alpha-oxoglutarate dehydrogenase activity
has related synonym: ketoglutaric dehydrogenase activity
has related synonym: OGDC activity
has related synonym: oxoglutarate decarboxylase activity
has exact synonym: oxoglutarate dehydrogenase (lipoamide) activity
has related synonym: oxoglutarate dehydrogenase activity

pantoate-beta-alanine ligase activity
type: Class
subclass of: GO_0016881
IAO_0000115: Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.
has related synonym: (R)-pantoate:beta-alanine ligase (AMP-forming)
has related synonym: D-pantoate:beta-alanine ligase (AMP-forming)
has related synonym: pantoate-activating enzyme activity
has related synonym: pantoic-activating enzyme activity
has related synonym: pantothenate synthetase activity

pantothenase activity
type: Class
subclass of: GO_0016811
IAO_0000115: Catalysis of the reaction: (R)-pantothenate + H(2)O = (R)-pantoate + beta-alanine.
has related synonym: (R)-pantothenate amidohydrolase activity
has related synonym: pantothenate amidohydrolase activity
has related synonym: pantothenate hydrolase activity

pantothenate kinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016773
IAO_0000115: Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate.
has related synonym: ATP:(R)-pantothenate 4'-phosphotransferase activity
has related synonym: ATP:pantothenate 4'-phosphotransferase activity
has related synonym: D-pantothenate kinase activity
has related synonym: pantothenate kinase (phosphorylating) activity
has related synonym: pantothenic acid kinase activity

pantetheine-phosphate adenylyltransferase activity
type: Class
subclass of: GO_0070566
IAO_0000115: Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate.
has related synonym: 3'-dephospho-CoA pyrophosphorylase activity
has related synonym: ATP:pantetheine-4'-phosphate adenylyltransferase activity
has exact synonym: ATP:pantetheine-phosphate adenylyltransferase activity
has related synonym: dephospho-CoA diphosphorylase activity
has related synonym: dephospho-CoA pyrophosphorylase activity
has related synonym: dephospho-coenzyme A pyrophosphorylase activity
has related synonym: pantetheine phosphate adenylyltransferase activity
has exact synonym: phosphopantetheine adenylyltransferase activity
has related synonym: PPAT activity

peptide alpha-N-acetyltransferase activity
type: Class
subclass of: GO_0034212
IAO_0000115: Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein.
has exact synonym: acetyl-CoA:peptide alpha-N-acetyltransferase activity
has exact synonym: acetyl-CoA:peptide nalpha-acetyltransferase activity
has related synonym: amino-terminal amino acid-acetylating enzyme activity
has related synonym: beta-endorphin acetyltransferase activity
has related synonym: N(alpha)-acetyltransferase activity
has exact synonym: nalpha-acetyltransferase activity
has related synonym: NAT activity
has related synonym: peptide acetyltransferase activity
has exact synonym: protein N-terminal acetyltransferase activity

peptidylamidoglycolate lyase activity
type: Class
subclass of: GO_0016842
subclass of: GO_0140096
IAO_0000115: Catalysis of the reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate.
has related synonym: alpha-hydroxyglycine amidating dealkylase activity
has related synonym: HGAD
has related synonym: PAL
has related synonym: peptidyl-alpha-hydroxyglycine alpha-amidating lyase activity
has related synonym: peptidylamidoglycolate peptidylamide-lyase (glyoxylate-forming)
has related synonym: peptidylamidoglycolate peptidylamide-lyase activity
has related synonym: PGL

obsolete cyclophilin
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. A protein to which cyclosporin A (an immunosuppressant) binds. Possesses peptidyl-prolyl isomerase activity.

peroxidase activity
type: Class
subclass of: GO_0016209
subclass of: GO_0016684
IAO_0000115: Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O.
has related synonym: bacterial catalase-peroxidase activity
has related synonym: donor:hydrogen-peroxide oxidoreductase activity
has related synonym: eosinophil peroxidase activity
has related synonym: extensin peroxidase
has related synonym: guaiacol peroxidase
has related synonym: heme peroxidase
has related synonym: horseradish peroxidase (HRP)
has related synonym: japanese radish peroxidase
has related synonym: lactoperoxidase activity
has related synonym: MPO
has related synonym: myeloperoxidase activity
has related synonym: oxyperoxidase activity
has exact synonym: peroxidase reaction
has related synonym: protoheme peroxidase
has related synonym: pyrocatechol peroxidase
has related synonym: scopoletin peroxidase
has related synonym: secretory plant peroxidase activity
has related synonym: thiocyanate peroxidase
has related synonym: verdoperoxidase
replaces: GO_0016685
replaces: GO_0016686
replaces: GO_0016687
replaces: GO_0016693

glutathione peroxidase activity
type: Class
subclass of: peroxidase activity
IAO_0000115: Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.
has related synonym: glutathione:hydrogen-peroxide oxidoreductase activity
has related synonym: GSH peroxidase activity
has related synonym: non-selenium glutathione peroxidase activity
has related synonym: reduced glutathione peroxidase activity
has related synonym: selenium-glutathione peroxidase activity
replaces: GO_0016224

phenylethanolamine N-methyltransferase activity
type: Class
subclass of: GO_0008170
subclass of: GO_0008757
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine.
has related synonym: noradrenaline N-methyltransferase activity
has related synonym: noradrenalin N-methyltransferase activity
has related synonym: norepinephrine methyltransferase activity
has related synonym: norepinephrine N-methyltransferase activity
has related synonym: phenethanolamine methyltransferase activity
has related synonym: phenethanolamine N-methyltransferase activity
has related synonym: S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase activity

phosphoadenylyl-sulfate reductase (thioredoxin) activity
type: Class
subclass of: GO_0016671
IAO_0000115: Catalysis of the reaction: adenosine 3',5'-diphosphate + H(+) + sulfite + thioredoxin disulfide = 3'-phospho-5'-adenylyl sulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS.
has related synonym: 3'-phosphoadenylylsulfate reductase activity
has related synonym: adenosine 3',5'-bisphosphate,sulfite:oxidized-thioredoxin oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)
has related synonym: adenosine 3',5'-bisphosphate,sulfite:thioredoxin-disulfide oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)
has related synonym: PAdoPS reductase activity
has related synonym: PAPS reductase, thioredoxin-dependent activity
has related synonym: PAPS reductase activity
has related synonym: PAPS sulfotransferase activity
has related synonym: phosphoadenosine-phosphosulfate reductase activity
has exact synonym: phosphoadenylyl-sulphate reductase (thioredoxin) activity
has related synonym: thioredoxin:3'-phospho-adenylylsulfate reductase activity
has related synonym: thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase activity

phosphatidate cytidylyltransferase activity
type: Class
subclass of: GO_0070567
IAO_0000115: Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
has related synonym: CDP-DG
has related synonym: CDP-diacylglyceride synthetase activity
has exact synonym: CDP-diacylglycerol synthase activity
has exact synonym: CDP-diglyceride diphosphorylase activity
has related synonym: CDP diglyceride pyrophosphorylase activity
has exact synonym: CDP-diglyceride pyrophosphorylase activity
has exact synonym: CDP-diglyceride synthase activity
has related synonym: CDP-diglyceride synthetase activity
has related synonym: CTP:1,2-diacylglycerophosphate-cytidyl transferase activity
has related synonym: CTP:phosphatidate cytidylyltransferase activity
has related synonym: CTP-diacylglycerol synthetase activity
has related synonym: cytidine diphosphoglyceride pyrophosphorylase activity
has related synonym: DAG synthetase activity
has related synonym: phosphatidate cytidyltransferase activity
has related synonym: phosphatidic acid cytidylyltransferase activity

phosphatidylcholine-sterol O-acyltransferase activity
type: Class
subclass of: GO_0008374
IAO_0000115: Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine.
has related synonym: LCAT (lecithin-cholesterol acyltransferase)
has related synonym: LCAT activity
has related synonym: lecithin:cholesterol acyltransferase activity
has related synonym: lecithin--cholesterol acyltransferase activity
has related synonym: phosphatidylcholine:sterol O-acyltransferase activity
has related synonym: phospholipid--cholesterol acyltransferase activity

phosphatidylethanolamine N-methyltransferase activity
type: Class
subclass of: GO_0008170
subclass of: GO_0008757
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + H(+) + phosphatidyl-N-methylethanolamine.
has related synonym: lipid methyl transferase activity
has related synonym: LMTase activity
has related synonym: PEMT
has related synonym: phosphatidylethanolamine methyltransferase activity
has related synonym: phosphatidylethanolamine-N-methylase activity
has related synonym: phosphatidylethanolamine-S-adenosylmethionine methyltransferase activity
has related synonym: S-adenosyl-L-methionine:phosphatidylethanolamine N-methyltransferase activity

phosphatidylserine decarboxylase activity
type: Class
subclass of: GO_0016831
IAO_0000115: Catalysis of the reaction: H(+) + phosphatidyl-L-serine = CO(2) + phosphatidylethanolamine.
has related synonym: phosphatidyl-L-serine carboxy-lyase (phosphatidylethanolamine-forming)
has related synonym: phosphatidyl-L-serine carboxy-lyase activity
has related synonym: PS decarboxylase activity

phosphoacetylglucosamine mutase activity
type: Class
subclass of: GO_0016868
IAO_0000115: Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate.
has related synonym: acetylaminodeoxyglucose phosphomutase activity
has related synonym: acetylglucosamine phosphomutase activity
has related synonym: N-acetyl-alpha-D-glucosamine 1,6-phosphomutase activity
has related synonym: N-acetyl-D-glucosamine 1,6-phosphomutase activity
has related synonym: N-acetylglucosamine-phosphate mutase activity
has related synonym: phospho-N-acetylglucosamine mutase activity

phosphoenolpyruvate carboxykinase activity
type: Class
subclass of: GO_0016831
IAO_0000115: Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2 + other reaction products.
has related synonym: PEP carboxykinase activity
has related synonym: PEPCK activity
has related synonym: phosphopyruvate carboxylase activity

phosphoenolpyruvate carboxykinase (ATP) activity
type: Class
subclass of: phosphoenolpyruvate carboxykinase activity
IAO_0000115: Catalysis of the reaction: ATP + oxaloacetate = ADP + CO(2) + H(+) + phosphoenolpyruvate.
has related synonym: ATP:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)
has related synonym: ATP:oxaloacetate carboxy-lyase (transphosphorylating)
has related synonym: PEPCK (ATP)
has related synonym: PEPK
has related synonym: phosphoenolpyruvate carboxylase (ATP)
has related synonym: phosphoenolpyruvic carboxykinase
has related synonym: phosphopyruvate carboxykinase
has related synonym: phosphopyruvate carboxykinase (adenosine triphosphate)
has related synonym: phosphopyruvate carboxylase (ATP)

phosphoenolpyruvate carboxykinase (GTP) activity
type: Class
subclass of: phosphoenolpyruvate carboxykinase activity
IAO_0000115: Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.
has related synonym: GTP:oxaloacetate carboxy-lyase (adding GTP; phosphoenolpyruvate-forming)
has related synonym: GTP:oxaloacetate carboxy-lyase (transphosphorylating)
has exact synonym: phosphoenolpyruvate carboxylase (GTP)
has related synonym: phosphoenolpyruvic carboxykinase
has related synonym: phosphoenolpyruvic carboxykinase (GTP)
has related synonym: phosphoenolpyruvic carboxylase (GTP)
has related synonym: phosphopyruvate (guanosine triphosphate) carboxykinase activity
has related synonym: phosphopyruvate carboxylase (GTP)

phosphoglucomutase activity
type: Class
subclass of: GO_0016868
IAO_0000115: Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.
has related synonym: alpha-D-glucose 1,6-phosphomutase activity
has related synonym: glucose phosphomutase activity
has related synonym: phosphoglucose mutase activity

phosphomannomutase activity
type: Class
subclass of: GO_0016868
IAO_0000115: Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.
has related synonym: alpha-D-mannose 1,6-phosphomutase activity
has related synonym: D-mannose 1,6-phosphomutase activity
has related synonym: mannose phosphomutase activity
has related synonym: phosphomannose mutase activity
replaces: GO_0008971

phosphogluconate dehydrogenase (decarboxylating) activity
type: Class
subclass of: GO_0016616
IAO_0000115: Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+.
has related synonym: 6PGD activity
has related synonym: 6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)
has related synonym: 6-phospho-D-gluconate dehydrogenase activity
has related synonym: 6-phosphogluconate dehydrogenase (decarboxylating)
has related synonym: 6-phosphogluconic carboxylase activity
has related synonym: 6-phosphogluconic dehydrogenase activity
has related synonym: phosphogluconic acid dehydrogenase activity

phosphoglycerate dehydrogenase activity
type: Class
subclass of: GO_0016616
IAO_0000115: Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+.
has related synonym: 3-phospho-D-glycerate:NAD+ 2-oxidoreductase activity
has related synonym: 3-phosphoglycerate:NAD+ 2-oxidoreductase activity
has related synonym: 3-phosphoglycerate dehydrogenase activity
has related synonym: 3-phosphoglyceric acid dehydrogenase activity
has related synonym: 3PHP reductase activity
has related synonym: alphaKG reductase activity
has related synonym: alpha-KG reductase activity
has related synonym: alpha-phosphoglycerate dehydrogenase activity
has related synonym: D-3-phosphoglycerate:NAD+ oxidoreductase activity
has related synonym: D-3-phosphoglycerate dehydrogenase activity
has related synonym: D- and L-HGA
has related synonym: glycerate-1,3-phosphate dehydrogenase activity
has related synonym: glycerate 3-phosphate dehydrogenase activity
has related synonym: PGDH activity
has related synonym: phosphoglycerate oxidoreductase activity
has related synonym: phosphoglyceric acid dehydrogenase activity
has related synonym: SerA
has related synonym: SerA 3PG dehydrogenase activity

phosphoglycerate kinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016774
IAO_0000115: Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H(+).
has related synonym: 3-PGK
has related synonym: 3-phosphoglycerate kinase activity
has related synonym: 3-phosphoglycerate phosphokinase activity
has related synonym: 3-phosphoglyceric acid kinase activity
has related synonym: 3-phosphoglyceric acid phosphokinase activity
has related synonym: 3-phosphoglyceric kinase activity
has related synonym: ATP:3-phospho-D-glycerate 1-phosphotransferase activity
has related synonym: ATP:D-3-phosphoglycerate 1-phosphotransferase activity
has related synonym: ATP-3-phospho-D-glycerate-1-phosphotransferase activity
has related synonym: glycerate 3-phosphate kinase activity
has related synonym: glycerophosphate kinase activity
has related synonym: PGK
has related synonym: phosphoglyceric acid kinase activity
has related synonym: phosphoglyceric kinase activity
has related synonym: phosphoglycerokinase activity

phosphoglycerate mutase activity
type: Class
subclass of: GO_0016868
IAO_0000115: Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate.
has related synonym: bisphosphoglyceromutase
has related synonym: diphosphoglycomutase
has related synonym: D-phosphoglycerate 2,3-phosphomutase activity
has related synonym: GriP mutase
has related synonym: monophosphoglycerate mutase activity
has related synonym: monophosphoglyceromutase activity
has related synonym: MPGM
has related synonym: PGAM activity
has related synonym: PGA mutase activity
has exact synonym: PGM
has related synonym: phosphoglycerate phosphomutase activity
has related synonym: phosphoglyceromutase activity

phospholipase activity
type: Class
subclass of: GO_0016298
IAO_0000115: Catalysis of the hydrolysis of a glycerophospholipid.

glycosylphosphatidylinositol phospholipase D activity
type: Class
subclass of: phospholipase D activity
IAO_0000115: Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol.
has related synonym: glycoprotein-phosphatidylinositol phosphatidohydrolase activity
has exact synonym: glycoprotein phospholipase D activity
has related synonym: GPI-PLD activity
has related synonym: phosphatidylinositol-glycan-specific phospholipase D activity
has related synonym: phosphatidylinositol phospholipase D activity
has related synonym: phosphatidylinositol-specific phospholipase D activity

lysophospholipase activity
type: Class
subclass of: phospholipase activity
subclass of: GO_0052689
IAO_0000115: Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.
has related synonym: 2-lysophosphatidylcholine acylhydrolase activity
has related synonym: lecithinase B activity
has related synonym: lecitholipase activity
has related synonym: lysolecithinase activity
has related synonym: lysophopholipase L2
has related synonym: lysophosphatidase activity
has related synonym: lysophosphatidylcholine hydrolase activity
has related synonym: lysophospholipase A1
has related synonym: phosphatidase B
has related synonym: phospholipase B activity
replaces: GO_0045126

phospholipase A2 activity
type: Class
subclass of: phospholipase activity
subclass of: GO_0052689
IAO_0000115: Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides.
has related synonym: cytosolic phospholipase A2 activity
has related synonym: lecithinase A activity
has related synonym: phosphatidase activity
has related synonym: phosphatidolipase activity
has related synonym: phosphatidylcholine 2-acylhydrolase activity
has related synonym: phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
has related synonym: phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
has related synonym: secreted phospholipase A2 activity
replaces: GO_0102567
replaces: GO_0102568

obsolete secreted phospholipase A2 activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion.

obsolete calcium-dependent secreted phospholipase A2 activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion.

obsolete cytosolic phospholipase A2 activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion.

obsolete calcium-dependent cytosolic phospholipase A2 activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion.

obsolete calcium-independent cytosolic phospholipase A2 activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion.

phospholipase C activity
type: Class
subclass of: phospholipase activity
subclass of: GO_0008081
IAO_0000115: Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate.
has related synonym: phosphatidase C
replaces: GO_0042298

phospholipase D activity
type: Class
subclass of: phospholipase activity
subclass of: GO_0008081
IAO_0000115: Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate.
has related synonym: choline phosphatase activity
has related synonym: lecithinase D activity
has related synonym: lipophosphodiesterase II activity
has related synonym: phosphatidylcholine phosphatidohydrolase activity

phosphomevalonate kinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016776
IAO_0000115: Catalysis of the reaction: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP + H(+).
has related synonym: 5-phosphomevalonate kinase activity
has related synonym: ATP:(R)-5-phosphomevalonate phosphotransferase activity
has related synonym: ATP:5-phosphomevalonate phosphotransferase activity
has related synonym: mevalonate-5-phosphate kinase activity
has related synonym: mevalonate phosphate kinase activity
has related synonym: mevalonic acid phosphate kinase activity

phosphopantothenate--cysteine ligase activity
type: Class
subclass of: GO_0016881
IAO_0000115: Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives.
has related synonym: (R)-4'-phosphopantothenate:L-cysteine ligase activity
has exact synonym: phosphopantothenate-cysteine ligase activity
has exact synonym: phosphopantothenoylcysteine synthetase activity

phosphopantothenoylcysteine decarboxylase activity
type: Class
subclass of: GO_0016831
IAO_0000115: Catalysis of the reaction: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate + H(+) = CO(2) + pantetheine 4'-phosphate.
has related synonym: 4-phosphopantothenoyl-L-cysteine decarboxylase activity
has related synonym: 4-phosphopantotheoylcysteine decarboxylase activity
has related synonym: N-((R)-4'-phosphopantothenoyl)-L-cysteine carboxy-lyase activity
has related synonym: N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming)
has related synonym: N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase activity
has related synonym: PPC-decarboxylase activity

phosphopyruvate hydratase activity
type: Class
subclass of: GO_0016836
IAO_0000115: Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O.
has related synonym: 14-3-2-protein
has exact synonym: 2-phospho-D-glycerate-hydrolase activity
has related synonym: 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
has related synonym: 2-phospho-D-glycerate hydro-lyase activity
has related synonym: 2-phosphoglycerate dehydratase activity
has related synonym: 2-phosphoglycerate enolase activity
has related synonym: 2-phosphoglyceric dehydratase activity
has related synonym: enolase activity
has related synonym: gamma-enolase activity
has related synonym: nervous-system specific enolase
has related synonym: phosphoenolpyruvate hydratase activity

phosphoribosyl-AMP cyclohydrolase activity
type: Class
subclass of: GO_0019238
IAO_0000115: Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H(2)O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide.
has related synonym: 1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase activity
has related synonym: phosphoribosyladenosine monophosphate cyclohydrolase activity
has related synonym: PRAMP-cyclohydrolase activity

phosphoribosyl-ATP diphosphatase activity
type: Class
subclass of: GO_0016462
IAO_0000115: Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H(2)O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H(+).
has related synonym: 1-(5-phosphoribosyl)-ATP diphosphohydrolase activity
has related synonym: phosphoribosyladenosine triphosphate pyrophosphatase activity
has exact synonym: phosphoribosyl-ATP pyrophosphatase activity

phosphoribosylamine-glycine ligase activity
type: Class
subclass of: GO_0016879
IAO_0000115: Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate.
has related synonym: 2-amino-N-ribosylacetamide 5'-phosphate kinosynthase activity
has related synonym: 5'-phosphoribosylglycinamide synthetase activity
has related synonym: 5-phospho-D-ribosylamine:glycine ligase (ADP-forming)
has related synonym: GAR
has related synonym: GARS activity
has related synonym: GAR synthetase activity
has related synonym: glycinamide ribonucleotide synthetase activity
has related synonym: glycineamide ribonucleotide synthetase activity
has related synonym: phosphoribosylglycinamide synthetase activity
has related synonym: phosphoribosylglycineamide synthetase activity

phosphoribosylaminoimidazole carboxylase activity
type: Class
subclass of: GO_0016831
IAO_0000115: Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2).
has related synonym: 1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase activity
has related synonym: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming]
has related synonym: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase activity
has related synonym: 5-amino-1-ribosylimidazole 5-phosphate carboxylase activity
has related synonym: 5-phosphoribosyl-5-aminoimidazole carboxylase activity
has related synonym: ADE2
has related synonym: AIR carboxylase activity
has related synonym: class II PurE

phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
type: Class
subclass of: GO_0016881
IAO_0000115: Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate.
has related synonym: 4-((N-succinylamino)carbonyl)-5-aminoimidazole ribonucleotide synthetase activity
has related synonym: 4-(N-succinocarboxamide)-5-aminoimidazole synthetase activity
has related synonym: 4-[(N-succinylamino)carbonyl]-5-aminoimidazole ribonucleotide synthetase activity
has related synonym: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming)
has related synonym: 5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase activity
has related synonym: phosphoribosylaminoimidazole-succinocarboxamide synthase activity
has related synonym: phosphoribosylaminoimidazolesuccinocarboxamide synthetase activity
has related synonym: phosphoribosylaminoimidazole-succinocarboxamide synthetase activity
has related synonym: PurC
has related synonym: SAICARs activity
has related synonym: SAICAR synthase activity
has related synonym: SAICAR synthetase activity

phosphoribosylanthranilate isomerase activity
type: Class
subclass of: GO_0016861
IAO_0000115: Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
has related synonym: IGPS:PRAI (indole-3-glycerol-phosphate synthetase/N-5'-phosphoribosylanthranilate isomerase complex)
has related synonym: N-(5'-phosphoribosyl)anthranilate isomerase activity
has related synonym: N-(5-phospho-beta-D-ribosyl)anthranilate aldose-ketose-isomerase activity
has related synonym: N-(5-phospho-beta-D-ribosyl)anthranilate ketol-isomerase activity
has related synonym: PRAI activity
has related synonym: PRA isomerase activity

phosphoribosylformylglycinamidine cyclo-ligase activity
type: Class
subclass of: GO_0016882
IAO_0000115: Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate.
has related synonym: 2-(formamido)-1-N-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)
has related synonym: 2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)
has related synonym: 5'-aminoimidazole ribonucleotide synthetase activity
has related synonym: AIRS activity
has related synonym: AIR synthase activity
has related synonym: AIR synthetase activity
has related synonym: phosphoribosylaminoimidazole synthetase activity
has related synonym: phosphoribosyl-aminoimidazole synthetase activity

phosphoribosylformylglycinamidine synthase activity
type: Class
subclass of: GO_0016884
IAO_0000115: Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate.
has related synonym: 2-N-formyl-1-N-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)
has related synonym: 5'-phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)
has related synonym: FGAM synthase activity
has related synonym: FGAM synthetase activity
has related synonym: FGAR amidotransferase activity
has related synonym: FGARAT activity
has related synonym: formylglycinamide ribonucloetide amidotransferase activity
has related synonym: formylglycinamide ribotide amidotransferase activity
has related synonym: N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)
has related synonym: phosphoribosylformylglycinamidine synthetase activity
has related synonym: phosphoribosylformylglycineamidine synthetase activity

phosphoribosylaminoimidazolecarboxamide formyltransferase activity
type: Class
subclass of: GO_0016742
IAO_0000115: Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide.
has related synonym: 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity
has related synonym: 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide N-formyltransferase activity
has related synonym: 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity
has related synonym: 5-amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase activity
has related synonym: 5-amino-4-imidazolecarboxamide ribonucleotide transformylase activity
has related synonym: 5-amino-4-imidazolecarboxamide ribotide transformylase activity
has related synonym: AICAR formyltransferase activity
has related synonym: AICAR transformylase activity
has related synonym: aminoimidazolecarboxamide ribonucleotide transformylase activity

phosphoribosylglycinamide formyltransferase activity
type: Class
subclass of: GO_0016742
IAO_0000115: Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide.
has related synonym: 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase activity
has related synonym: 2-amino-N-ribosylacetamide 5'-phosphate transformylase activity
has related synonym: 5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase activity
has related synonym: 5'-phosphoribosylglycinamide transformylase activity
has related synonym: GAR formyltransferase activity
has related synonym: GART activity
has related synonym: GAR TFase activity
has related synonym: GAR transformylase activity
has related synonym: glycinamide ribonucleotide transformylase activity

1,4-alpha-oligoglucan phosphorylase activity
type: Class
subclass of: GO_0016758
IAO_0000115: Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase.
has related synonym: 1,4-alpha-D-glucan:phosphate alpha-D-glucosyltransferase activity
has related synonym: 1,4-alpha-glucan phosphorylase activity
has related synonym: alpha-glucan phosphorylase
has related synonym: amylopectin phosphorylase
has related synonym: amylophosphorylase activity
has related synonym: glucan phosphorylase
has related synonym: glucosan phosphorylase
has related synonym: granulose phosphorylase
has related synonym: muscle phosphorylase
has related synonym: muscle phosphorylase a and b activity
has related synonym: myophosphorylase
has related synonym: polyphosphorylase activity
has related synonym: potato phosphorylase
has related synonym: starch phosphorylase

O-phospho-L-serine:2-oxoglutarate aminotransferase activity
type: Class
subclass of: GO_0008483
IAO_0000115: Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.
has related synonym: 3-O-phospho-L-serine:2-oxoglutarate aminotransferase activity
has related synonym: 3-phosphoserine aminotransferase activity
has related synonym: 3PHP transaminase activity
has related synonym: hydroxypyruvic phosphate--glutamic transaminase activity
has related synonym: L-phosphoserine aminotransferase activity
has related synonym: PdxC
has related synonym: phosphohydroxypyruvate transaminase activity
has related synonym: phosphohydroxypyruvic--glutamic transaminase activity
has related synonym: phosphoserine aminotransferase activity
has related synonym: phosphoserine transaminase activity
has related synonym: PSAT activity
has related synonym: SerC
replaces: GO_0004646

poly(ADP-ribose) glycohydrolase activity
type: Class
subclass of: hydrolase activity, hydrolyzing O-glycosyl compounds
IAO_0000115: Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose.

polygalacturonase activity
type: Class
subclass of: hydrolase activity, hydrolyzing O-glycosyl compounds
IAO_0000115: Catalysis of the random hydrolysis of (1->4)-alpha-D-galactosiduronic linkages in pectate and other galacturonans.
has exact synonym: endo-D-galacturonase activity
has exact synonym: endogalacturonase activity
has exact synonym: endopolygalacturonase activity
has exact synonym: endo-polygalacturonase activity
has related synonym: pectinase activity
has related synonym: pectin depolymerase activity
has related synonym: pectin hydrolase activity
has related synonym: pectin polygalacturonase activity
has related synonym: pectolase activity
has exact synonym: poly(1,4-alpha-D-galacturonide) glycanohydrolase activity
has exact synonym: poly-alpha-1,4-galacturonide glycanohydrolase activity

polynucleotide 5'-phosphatase activity
type: Class
subclass of: GO_0016791
IAO_0000115: Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate.
has related synonym: 5'-polynucleotidase activity
has related synonym: polynucleotide 5'-phosphohydrolase activity
has related synonym: polynucleotide 5'-triphosphatase activity

polynucleotide adenylyltransferase activity
type: Class
subclass of: GO_0070566
IAO_0000115: Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group.
has related synonym: adenosine triphosphate:ribonucleic acid adenylyltransferase activity
has related synonym: AMP polynucleotidylexotransferase activity
has related synonym: ATP:polynucleotide adenylyltransferase activity
has related synonym: ATP:polynucleotidylexotransferase activity
has related synonym: ATP-polynucleotide adenylyltransferase activity
has related synonym: NTP polymerase activity
has related synonym: poly(A) hydrolase activity
has related synonym: poly(A) polymerase activity
has related synonym: poly(A) synthetase activity
has related synonym: polyadenylate nucleotidyltransferase activity
has related synonym: polyadenylate polymerase activity
has related synonym: polyadenylate synthetase activity
has related synonym: polyadenylic acid polymerase activity
has related synonym: polyadenylic polymerase activity
has related synonym: poly-A polymerase activity
has related synonym: RNA adenylating enzyme activity
has related synonym: RNA formation factors, PF1
has related synonym: terminal riboadenylate transferase activity

polypeptide N-acetylgalactosaminyltransferase activity
type: Class
subclass of: GO_0008376
subclass of: GO_0140096
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis.
has related synonym: glycoprotein acetylgalactosaminyltransferase activity
has related synonym: polypeptide-N-acetylgalactosamine transferase activity
has related synonym: protein-UDP acetylgalactosaminyltransferase activity
has related synonym: UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase activity
has related synonym: UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity
has related synonym: UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase activity
has related synonym: UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase activity
has related synonym: UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase activity
has related synonym: UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase activity
has related synonym: UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase activity
has related synonym: UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase activity
has related synonym: UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase activity
has related synonym: UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase activity
has related synonym: UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase activity
has related synonym: uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity

polyribonucleotide nucleotidyltransferase activity
type: Class
subclass of: GO_0016779
IAO_0000115: Catalysis of the reaction: RNA(n+1) + phosphate <=> RNA(n) + a nucleoside diphosphate.
has related synonym: nucleoside diphosphate:polynucleotidyl transferase activity
has related synonym: polynucleotide phosphorylase activity
has related synonym: polyribonucleotide:phosphate nucleotidyltransferase activity
has related synonym: polyribonucleotide phosphorylase activity

porphobilinogen synthase activity
type: Class
subclass of: GO_0016836
IAO_0000115: Catalysis of the reaction: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen.
has related synonym: 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming)
has related synonym: 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing)
has related synonym: 5-levulinic acid dehydratase activity
has exact synonym: aminolevulinate dehydratase activity
has related synonym: aminolevulinic dehydratase activity
has related synonym: delta-aminolevulinate dehydratase activity
has related synonym: delta-aminolevulinic acid dehydrase activity
has exact synonym: delta-aminolevulinic acid dehydratase activity
has related synonym: delta-aminolevulinic dehydratase activity

procollagen-proline 4-dioxygenase activity
type: Class
subclass of: GO_0019798
subclass of: GO_0031545
IAO_0000115: Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2.
has related synonym: collagen proline hydroxylase activity
has related synonym: hydroxylase, collagen proline activity
has related synonym: peptidyl proline hydroxylase activity
has related synonym: procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) activity
has exact synonym: procollagen-proline,2-oxoglutarate-4-dioxygenase activity
has related synonym: proline,2-oxoglutarate 4-dioxygenase activity
has related synonym: proline, 2-oxoglutarate dioxygenase activity
has related synonym: proline hydroxylase activity
has related synonym: proline protocollagen hydroxylase activity
has related synonym: prolyl 4-hydroxylase activity
has related synonym: prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating activity
has related synonym: prolyl hydroxylase activity
has related synonym: prolylprotocollagen dioxygenase activity
has related synonym: prolylprotocollagen hydroxylase activity
has related synonym: protocollagen hydroxylase activity
has related synonym: protocollagen proline 4-hydroxylase activity
has related synonym: protocollagen proline dioxygenase activity
has related synonym: protocollagen proline hydroxylase activity
has related synonym: protocollagen prolyl hydroxylase activity

proline dehydrogenase activity
type: Class
subclass of: GO_0016649
IAO_0000115: Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor.
has related synonym: L-proline dehydrogenase activity

propionyl-CoA carboxylase activity
type: Class
subclass of: GO_0016421
IAO_0000115: Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA.
has related synonym: PCCase activity
has related synonym: propanoyl-CoA:carbon-dioxide ligase (ADP-forming)
has related synonym: propionyl coenzyme A carboxylase activity

prenyltransferase activity
type: Class
subclass of: GO_0016765
IAO_0000115: Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor).

protein farnesyltransferase activity
type: Class
subclass of: GO_0008318
IAO_0000115: Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
has related synonym: CAAX farnesyltransferase activity
has related synonym: farnesyl-diphosphate:protein-cysteine farnesyltransferase activity
has related synonym: FTase activity
has exact synonym: protein-cysteine farnesyltransferase activity
replaces: GO_0018223

protein geranylgeranyltransferase activity
type: Class
subclass of: GO_0008318
IAO_0000115: Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.
has exact synonym: protein-cysteine geranylgeranyltransferase activity
replaces: GO_0018224

CAAX-protein geranylgeranyltransferase activity
type: Class
subclass of: protein geranylgeranyltransferase activity
IAO_0000115: Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.
has exact synonym: geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity
has exact synonym: geranylgeranyltransferase type I activity
has exact synonym: GGTaseI activity
has exact synonym: GGTase-I activity
has related synonym: protein geranylgeranyltransferase type I
has related synonym: type I protein geranyl-geranyltransferase activity

Rab geranylgeranyltransferase activity
type: Class
subclass of: protein geranylgeranyltransferase activity
IAO_0000115: Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family.
has exact synonym: geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity
has exact synonym: GGTaseII activity
has exact synonym: GGTase-II activity
has exact synonym: protein geranylgeranyltransferase type II activity
has exact synonym: RabGGTase activity
has exact synonym: Rab-protein geranylgeranyltransferase activity
has related synonym: type II protein geranyl-geranyltransferase activity

prephenate dehydratase activity
type: Class
subclass of: GO_0016836
IAO_0000115: Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2.
has related synonym: prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming)
has related synonym: prephenate hydro-lyase (decarboxylating)

prephenate dehydrogenase (NADP+) activity
type: Class
subclass of: GO_0016628
IAO_0000115: Catalysis of the reaction: NADP(+) + prephenate = (4-hydroxyphenyl)pyruvate + CO(2) + NADPH.
has related synonym: prephenate:NADP+ oxidoreductase (decarboxylating)
has related synonym: prephenate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity

prostaglandin-endoperoxide synthase activity
type: Class
subclass of: GO_0016705
IAO_0000115: Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O.
has related synonym: (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase activity
has related synonym: (PG)H synthase activity
has related synonym: fatty acid cyclooxygenase activity
has related synonym: PG synthetase activity
has related synonym: prostaglandin endoperoxide synthetase activity
has related synonym: prostaglandin G/H synthase activity
has related synonym: prostaglandin synthase activity
has related synonym: prostaglandin synthetase activity

prostaglandin-D synthase activity
type: Class
subclass of: GO_0016860
IAO_0000115: Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2).
has related synonym: (5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase activity
has related synonym: PGD2 synthase activity
has related synonym: PGH-PGD isomerase activity
has related synonym: prostaglandin D2 synthase activity
has related synonym: prostaglandin-H2 D-isomerase activity
has related synonym: prostaglandin-R-prostaglandin D isomerase activity

protein-arginine deiminase activity
type: Class
subclass of: GO_0016813
IAO_0000115: Catalysis of the reaction: H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4+, resulting in citrullination of the target protein. This reaction is calcium-dependent.
has related synonym: peptidylarginine deiminase activity
has related synonym: protein-L-arginine iminohydrolase activity

protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
type: Class
subclass of: protein C-terminal carboxyl O-methyltransferase activity
subclass of: GO_0008757
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.
has related synonym: farnesylated protein C-terminal O-methyltransferase activity
has related synonym: farnesyl cysteine C-terminal methyltransferase activity
has related synonym: farnesyl-protein carboxymethyltransferase activity
has related synonym: isoprenylated protein methyltransferase activity
has related synonym: isoprenylcysteine carboxylmethyltransferase activity
has related synonym: prenylated protein carboxyl methyltransferase activity
has related synonym: prenylated protein methyltransferase activity
has related synonym: prenylcysteine carboxylmethyltransferase activity
has related synonym: prenylcysteine carboxyl methyltransferase activity
has related synonym: prenylcysteine carboxymethyltransferase activity
has related synonym: prenylcysteine methyltransferase activity
has related synonym: protein C-terminal farnesylcysteine O-methyltransferase activity
has related synonym: protein S-farnesylcysteine C-terminal methyltransferase activity
has exact synonym: protein-S-isoprenylcysteine O-methyltransferase activity
has related synonym: S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase activity
has related synonym: S-farnesylcysteine methyltransferase activity
replaces: GO_0018225

protein kinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016773
subclass of: GO_0140096
IAO_0000115: Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
has related synonym: protamine kinase activity
replaces: GO_0050222

protein histidine kinase activity
type: Class
subclass of: protein kinase activity
subclass of: GO_0016775
subclass of: part-of-parent-18106
IAO_0000115: Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine.
has related synonym: ATP:protein-L-histidine N-phosphotransferase activity
has related synonym: EnvZ
has related synonym: histidine kinase (ambiguous)
has exact synonym: histidine kinase activity
has related synonym: histidine protein kinase (ambiguous)
has related synonym: histidine protein kinase activity
has related synonym: HK1
has related synonym: HP165
has related synonym: protein histidine kinase (ambiguous)
has exact synonym: protein-histidine kinase activity
has related synonym: protein kinase (histidine)
has related synonym: protein kinase (histidine) (ambiguous)
has related synonym: Sln1p
replaces: GO_0008896

protein serine/threonine kinase activity
type: Class
subclass of: protein kinase activity
IAO_0000115: Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
has related synonym: protein kinase (phosphorylating) activity
has related synonym: protein phosphokinase activity
has related synonym: protein serine kinase activity
has related synonym: protein-serine kinase activity
has related synonym: protein serine-threonine kinase activity
has related synonym: protein threonine kinase activity
has related synonym: serine/threonine protein kinase activity
has related synonym: serine(threonine) protein kinase activity
has related synonym: serine kinase activity
has related synonym: serine protein kinase activity
has related synonym: serine-specific protein kinase activity
has related synonym: threonine-specific protein kinase activity
replaces: GO_0004695
replaces: GO_0004696
replaces: GO_0004700
replaces: GO_0106311

transmembrane receptor protein serine/threonine kinase activity
type: Class
subclass of: protein serine/threonine kinase activity
subclass of: GO_0019199
subclass of: part-of-parent-7178
IAO_0000115: Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
has related synonym: receptor protein serine/threonine kinase activity
has related synonym: receptor serine/threonine protein kinase activity

3-phosphoinositide-dependent protein kinase activity
type: Class
subclass of: protein serine/threonine kinase activity
IAO_0000115: Phosphatidylinositol-3-phosphate-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.
has related synonym: PDK activity
has exact synonym: phosphatidylinositol-3-phosphate protein kinase activity

DNA-dependent protein kinase activity
type: Class
subclass of: protein serine/threonine kinase activity
IAO_0000115: DNA dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.

AMP-activated protein kinase activity
type: Class
subclass of: protein serine/threonine kinase activity
IAO_0000115: Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP.
has exact synonym: 5'-AMP-activated protein kinase activity
has related synonym: AMPK activity
has related synonym: SNF1A/AMP-activated protein kinase activity

obsolete casein kinase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete casein kinase I activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

obsolete protein kinase CK2 activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Catalysis of the reaction: casein + ATP = phosphocasein + ADP.
replaces: GO_0008604

calmodulin-dependent protein kinase activity
type: Class
subclass of: protein serine/threonine kinase activity
IAO_0000115: Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate.
has related synonym: ATP:caldesmon O-phosphotransferase activity
has related synonym: ATP:protein phosphotransferase (Ca2+/calmodulin-dependent) activity
has related synonym: Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase activity
has related synonym: Ca2+/calmodulin-dependent protein kinase 1 activity
has related synonym: Ca2+/calmodulin-dependent protein kinase activity
has related synonym: Ca2+/calmodulin-dependent protein kinase II activity
has related synonym: Ca2+/calmodulin-dependent protein kinase IV activity
has related synonym: Ca2+/calmodulin-dependent protein kinase kinase activity
has related synonym: Ca2+/calmodulin-dependent protein kinase kinase beta activity
has exact synonym: Ca2+/CaM-dependent kinase activity
has related synonym: calcium/calmodulin-dependent protein kinase activity
has related synonym: calcium/calmodulin-dependent protein kinase type II activity
has exact synonym: calcium- and calmodulin-dependent protein kinase activity
has related synonym: caldesmon kinase (phosphorylating) activity
has related synonym: calmodulin-dependent kinase II activity
has related synonym: calmodulin-dependent protein kinase I activity
has exact synonym: calmodulin regulated protein kinase activity
has related synonym: CaMKI
has related synonym: CaMKII
has related synonym: CaM kinase activity
has related synonym: CaM kinase II activity
has related synonym: CaMKIV
has related synonym: CaMKKalpha
has related synonym: CaMKKbeta
has related synonym: CAM PKII
has related synonym: CaM-regulated serine/threonine kinase activity
has related synonym: microtubule-associated protein 2 kinase activity
has related synonym: multifunctional calcium/calmodulin regulated protein kinase activity
has related synonym: multifunctional calcium- and calmodulin-regulated protein kinase activity
has related synonym: STK20
replaces: GO_0004684
replaces: GO_0004685
replaces: GO_0004688

elongation factor-2 kinase activity
type: Class
subclass of: calmodulin-dependent protein kinase activity
IAO_0000115: Catalysis of the reaction: ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate.
has related synonym: ATP:elongation factor 2 phosphotransferase activity
has related synonym: Ca/CaM-kinase III activity
has related synonym: calmodulin-dependent protein kinase III activity
has related synonym: CaM kinase III activity
has related synonym: eEF2K
has related synonym: eEF2 kinase activity
has exact synonym: eEF-2 kinase activity
has related synonym: EF2K
has related synonym: elongation factor 2 kinase activity
has related synonym: eukaryotic elongation factor 2 kinase activity
has related synonym: STK19

myosin light chain kinase activity
type: Class
subclass of: protein serine/threonine kinase activity
IAO_0000115: Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate.
has related synonym: ATP:myosin-light-chain O-phosphotransferase
has related synonym: ATP:myosin-light-chain O-phosphotransferase activity
has related synonym: calcium/calmodulin-dependent myosin light chain kinase activity
has related synonym: MLCK
has related synonym: MLCkase activity
has related synonym: myosin kinase activity
has related synonym: myosin light-chain kinase
has related synonym: myosin light-chain kinase (phosphorylating)
has related synonym: myosin light-chain kinase (phosphorylating) activity
has related synonym: myosin light-chain kinase activity
has exact synonym: myosin-light-chain kinase activity
has related synonym: myosin light chain protein kinase activity
has related synonym: smooth-muscle-myosin-light-chain kinase activity
has related synonym: STK18

phosphorylase kinase activity
type: Class
subclass of: calmodulin-dependent protein kinase activity
IAO_0000115: Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a.
has related synonym: ATP:phosphorylase-b phosphotransferase activity
has related synonym: dephosphophosphorylase kinase activity
has related synonym: glycogen phosphorylase kinase activity
has related synonym: PHK
has related synonym: phosphorylase B kinase activity
has exact synonym: phosphorylase kinase, intrinsic catalyst activity
has related synonym: phosphorylase kinase (phosphorylating) activity
has related synonym: STK17
replaces: GO_0008606

cyclic nucleotide-dependent protein kinase activity
type: Class
subclass of: protein serine/threonine kinase activity
IAO_0000115: cNMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.

cAMP-dependent protein kinase activity
type: Class
subclass of: cyclic nucleotide-dependent protein kinase activity
IAO_0000115: cAMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.
has exact synonym: 3',5' cAMP-dependent protein kinase activity
has exact synonym: 3',5'-cAMP-dependent protein kinase activity
has exact synonym: adenosine 3',5'-cyclophosphate-dependent protein kinase activity
has related synonym: AMPK
has related synonym: ATP:protein phosphotransferase (cAMP-dependent) activity
has exact synonym: cAMP-dependent protein kinase, intrinsic catalyst activity
has exact synonym: cyclic AMP-dependent protein kinase activity
has related synonym: PKA
has related synonym: PKA C
has related synonym: protein kinase A activity
has related synonym: STK22
replaces: GO_0008602

cGMP-dependent protein kinase activity
type: Class
subclass of: cyclic nucleotide-dependent protein kinase activity
IAO_0000115: cGMP dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.
has related synonym: 3':5'-cyclic GMP-dependent protein kinase activity
has related synonym: ATP:protein phosphotransferase (cGMP-dependent) activity
has related synonym: cGMP-dependent protein kinase ibeta activity
has related synonym: guanosine 3':5'-cyclic monophosphate-dependent protein kinase activity
has related synonym: PKG
has related synonym: PKG 1alpha
has related synonym: PKG 1beta
has related synonym: PKG II
has related synonym: STK23

cyclin-dependent protein serine/threonine kinase activity
type: Class
subclass of: protein serine/threonine kinase activity
subclass of: GO_0097472
IAO_0000115: Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
has related synonym: ATP:cyclin phosphotransferase activity
has related synonym: cdc2 kinase activity
has related synonym: CDK
has exact synonym: CDK, catalytic subunit activity
has related synonym: cdk-activating kinase activity
has related synonym: Cdk-activating protein kinase activity
has exact synonym: CDK activity
has related synonym: cyclin-A associated kinase activity
has related synonym: cyclin D-cdk6 kinase activity
has related synonym: cyclin D-dependent kinase activity
has related synonym: cyclin-dependent kinase-2 activity
has related synonym: cyclin-dependent kinase-4 activity
has related synonym: cyclin-dependent kinase 6 activity
has related synonym: cyclin-dependent kinase activity
has exact synonym: cyclin-dependent protein kinase, intrinsic catalyst activity
has related synonym: cyclin-dependent protein kinase activity
has related synonym: cyclin E kinase activity
has related synonym: D-type cyclin kinase activity
has related synonym: neuronal cdc2-like kinase activity
replaces: GO_0016537

eukaryotic translation initiation factor 2alpha kinase activity
type: Class
subclass of: protein serine/threonine kinase activity
subclass of: GO_0045182
subclass of: part-of-parent-10998
IAO_0000115: Catalysis of the reaction: ATP + [eukaryotic translation initiation factor 2 alpha subunit] = ADP + [eukaryotic translation initiation factor 2 alpha subunit] phosphate.

protein kinase C activity
type: Class
subclass of: protein serine/threonine kinase activity
IAO_0000115: Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol.
has related synonym: ATP:protein phosphotransferase (diacylglycerol-dependent) activity
has related synonym: cPKC
has related synonym: cPKCalpha
has related synonym: cPKCbeta
has related synonym: cPKCgamma
has exact synonym: diacylglycerol-activated phospholipid-dependent PKC activity
has exact synonym: diacylglycerol-activated phospholipid-dependent protein kinase C activity
has related synonym: nPKC
has related synonym: nPKCdelta
has related synonym: nPKCepsilon
has related synonym: nPKCeta
has related synonym: nPKCtheta
has related synonym: PKC
has related synonym: Pkc1p
has exact synonym: PKC activity
has related synonym: PKCalpha
has related synonym: PKCbeta
has related synonym: PKCdelta
has related synonym: PKCepsilon
has related synonym: PKCgamma
has related synonym: PKCzeta
has related synonym: protein kinase Cepsilon activity
has related synonym: STK24
replaces: GO_0004701

calcium-dependent protein kinase C activity
type: Class
subclass of: protein kinase C activity
subclass of: GO_0009931
IAO_0000115: Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.
has exact synonym: calcium-dependent PKC activity
has exact synonym: conventional protein kinase C activity

calcium-independent protein kinase C activity
type: Class
subclass of: protein kinase C activity
IAO_0000115: Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium.
has exact synonym: calcium-independent PKC activity
has exact synonym: novel protein kinase C activity

obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

G protein-coupled receptor kinase activity
type: Class
subclass of: protein serine/threonine kinase activity
IAO_0000115: Catalysis of the reaction: ATP + G protein-coupled receptor = ADP + G protein-coupled receptor phosphate.
has related synonym: ATP:G-protein-coupled receptor phosphotransferase activity
has related synonym: GPCRK
has related synonym: GPCR kinase activity
has exact synonym: GPCR phosphorylating protein kinase activity
has related synonym: G-protein coupled receptor kinase activity
has exact synonym: G protein coupled receptor phosphorylating protein kinase activity
has exact synonym: G-protein-coupled receptor phosphorylating protein kinase activity
has related synonym: GRK4
has related synonym: GRK5
has related synonym: GRK6
has related synonym: STK16
replaces: GO_0004678

NF-kappaB-inducing kinase activity
type: Class
subclass of: GO_0030234
subclass of: part-of-parent-38061
IAO_0000115: Catalysis of the phosphorylation of the alpha or beta subunit of the inhibitor of kappaB kinase complex (IKK).
has exact synonym: NIK

JUN kinase activity
type: Class
subclass of: MAP kinase activity
subclass of: part-of-parent-7254
IAO_0000115: Catalysis of the reaction: JUN + ATP = JUN phosphate + ADP. This reaction is the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors.
has related synonym: c-Jun N-terminal kinase activity
has exact synonym: JNK
has related synonym: JNK3alpha1
has related synonym: SAPK1

JUN kinase kinase kinase activity
type: Class
subclass of: MAP kinase kinase kinase activity
IAO_0000115: Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs).
has related synonym: JNK kinase kinase activity
has exact synonym: JNKKK

MAP kinase activity
type: Class
subclass of: protein serine/threonine kinase activity
subclass of: part-of-parent-165
IAO_0000115: Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
has related synonym: ATP:protein phosphotransferase (MAPKK-activated) activity
has related synonym: ERK
has exact synonym: ERK1
has related synonym: ERK2
has related synonym: extracellular signal-regulated kinase activity
has related synonym: MAPK
has related synonym: MAP kinase 1 activity
has related synonym: MAP kinase 2 activity
has related synonym: MBP kinase I activity
has related synonym: MBP kinase II activity
has exact synonym: mitogen activated kinase activity
has related synonym: mitogen-activated protein kinase activity
has related synonym: myelin basic protein kinase activity
has related synonym: SAPK
has related synonym: SAP kinase activity
has related synonym: stress-activated kinase activity
has related synonym: stress-activated protein kinase activity
replaces: GO_0008338
replaces: GO_0008339
replaces: GO_0016908
replaces: GO_0016909

MAP kinase kinase activity
type: Class
subclass of: protein serine/threonine/tyrosine kinase activity
subclass of: part-of-parent-165
IAO_0000115: Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
has related synonym: ATP:protein phosphotransferase (MAPKKK-activated) activity
has exact synonym: ERK activator kinase activity
has related synonym: MAP2K
has exact synonym: MAPK activator activity
has related synonym: MAP kinase kinase 4 activity
has related synonym: MAP kinase kinase 7 activity
has related synonym: MAP kinase or ERK kinase activity
has related synonym: MAPKK
has related synonym: MAPKK1
has exact synonym: MAPKK activity
has related synonym: MEK1
has related synonym: MEK2
has related synonym: MEK activity
has related synonym: mitogen-activated protein kinase kinase activity
has related synonym: MKK
has related synonym: MKK2
has related synonym: MKK4
has related synonym: MKK6
has related synonym: MKK7
has related synonym: STK27

MAP kinase kinase kinase activity
type: Class
subclass of: protein serine/threonine kinase activity
subclass of: part-of-parent-165
IAO_0000115: Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
has related synonym: ATP:protein phosphotransferase (MAPKKKK-activated) activity
has related synonym: cMos
has related synonym: cRaf
has related synonym: MAP3K
has exact synonym: MAPK/ERK kinase kinase activity
has related synonym: MAPKKK activity
has related synonym: MEKK
has related synonym: MEKK1
has related synonym: MEKK2
has related synonym: MEKK3
has exact synonym: MEKK activity
has related synonym: MEK kinase activity
has related synonym: Mil/Raf
has related synonym: mitogen-activated protein kinase kinase kinase activity
has related synonym: MLK-like mitogen-activated protein triple kinase activity
has related synonym: MLTK
has related synonym: MLTKa
has related synonym: MLTKb
has related synonym: REKS
has related synonym: STK28
replaces: GO_0004710

ribosomal protein S6 kinase activity
type: Class
subclass of: protein serine/threonine kinase activity
IAO_0000115: Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP.

protein serine/threonine/tyrosine kinase activity
type: Class
subclass of: protein kinase activity
IAO_0000115: Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
has exact synonym: dual-specificity kinase activity
has exact synonym: dual-specificity protein kinase
has related synonym: protein threonine/tyrosine kinase activity

protein tyrosine kinase activity
type: Class
subclass of: protein kinase activity
subclass of: part-of-parent-18108
IAO_0000115: Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
has exact synonym: protein-tyrosine kinase activity
replaces: GO_0004718

transmembrane receptor protein tyrosine kinase activity
type: Class
subclass of: protein tyrosine kinase activity
subclass of: GO_0019199
IAO_0000115: Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
has related synonym: receptor protein tyrosine kinase activity
has related synonym: receptor protein-tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity
type: Class
subclass of: protein tyrosine kinase activity
IAO_0000115: Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
has related synonym: ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity
has related synonym: ATP:protein-tyrosine O-phosphotransferase activity
has related synonym: Bruton's tyrosine kinase activity
has related synonym: cytoplasmic protein tyrosine kinase activity
has related synonym: focal adhesion kinase activity
has related synonym: janus kinase 1 activity
has related synonym: janus kinase 2 activity
has related synonym: janus kinase 3 activity
has related synonym: non-specific protein-tyrosine kinase activity
has related synonym: p60c-src protein tyrosine kinase activity

obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

obsolete focal adhesion kinase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
type: Class
subclass of: GO_0008757
subclass of: GO_0051998
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester.
has related synonym: D-aspartyl/L-isoaspartyl methyltransferase activity
has related synonym: L-aspartyl/L-isoaspartyl protein methyltransferase activity
has related synonym: L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase activity
has related synonym: L-isoaspartyl protein carboxyl methyltransferase activity
has related synonym: protein (D-aspartate) methyltransferase activity
has related synonym: protein beta-aspartate O-methyltransferase activity
has related synonym: protein-beta-aspartate O-methyltransferase activity
has related synonym: protein D-aspartate methyltransferase activity
has related synonym: protein-L-isoaspartate(D-aspartate) O-methyltransferase activity
has related synonym: protein L-isoaspartate methyltransferase activity
has related synonym: protein-L-isoaspartate O-methyltransferase activity
has related synonym: protein L-isoaspartyl methyltransferase activity
has related synonym: protein O-methyltransferase (L-isoaspartate)
has related synonym: S-adenosyl-L-methionine:protein-L-isoaspartate O-methyltransferase activity

protein-lysine 6-oxidase activity
type: Class
subclass of: GO_0016641
subclass of: GO_0140096
IAO_0000115: Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + hydrogen peroxide.
has related synonym: lysyl oxidase activity
has related synonym: protein-L-lysine:oxygen 6-oxidoreductase (deaminating)
replaces: GO_0018056

phosphoprotein phosphatase activity
type: Class
subclass of: GO_0016791
subclass of: GO_0140096
IAO_0000115: Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.
has exact synonym: phosphoprotein phosphohydrolase activity
has related synonym: protein phosphatase-1 activity
has related synonym: protein phosphatase-2A activity
has related synonym: protein phosphatase-2B activity
has related synonym: protein phosphatase-2C activity
has exact synonym: protein phosphatase activity

protein serine/threonine phosphatase activity
type: Class
subclass of: phosphoprotein phosphatase activity
IAO_0000115: Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
has related synonym: magnesium-dependent protein serine/threonine phosphatase activity
has related synonym: phosphatase I
has related synonym: phosphatase II
has related synonym: phosphatase III
has related synonym: protein phosphatase-1
has related synonym: protein phosphatase-2A
has related synonym: protein phosphatase-2B
has related synonym: protein phosphatase-2C
has related synonym: protein phosphatase type 1 activity
has related synonym: protein phosphatase type 2A activity
has related synonym: protein phosphatase type 2B activity
has related synonym: protein phosphatase type 2C activity
has related synonym: protein serine phosphatase activity
has related synonym: protein threonine phosphatase activity
has exact synonym: serine/threonine specific protein phosphatase activity
replaces: GO_0000158
replaces: GO_0000163
replaces: GO_0004724
replaces: GO_0008598
replaces: GO_0008600
replaces: GO_0015071
replaces: GO_0030357
replaces: GO_0030358
replaces: GO_0030360
replaces: GO_0030361
replaces: GO_0106306
replaces: GO_0106307

calcium-dependent protein serine/threonine phosphatase activity
type: Class
subclass of: protein serine/threonine phosphatase activity
IAO_0000115: Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions.
has related synonym: calcineurin
has exact synonym: calcium-dependent protein serine/threonine phosphatase, intrinsic catalyst activity
replaces: GO_0008596

protein tyrosine phosphatase activity
type: Class
subclass of: phosphoprotein phosphatase activity
IAO_0000115: Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
has related synonym: [phosphotyrosine]protein phosphatase activity
has related synonym: phosphoprotein phosphatase (phosphotyrosine) activity
has related synonym: phosphotyrosine histone phosphatase activity
has related synonym: phosphotyrosine phosphatase activity
has related synonym: phosphotyrosine protein phosphatase activity
has related synonym: phosphotyrosylprotein phosphatase activity
has related synonym: PPT-phosphatase activity
has related synonym: protein phosphotyrosine phosphatase activity
has related synonym: protein-tyrosine-phosphatase activity
has related synonym: protein-tyrosine-phosphate phosphohydrolase activity
has related synonym: PTPase activity
has related synonym: PTP-phosphatase activity
has related synonym: tyrosine O-phosphate phosphatase activity
has related synonym: tyrosylprotein phosphatase activity

non-membrane spanning protein tyrosine phosphatase activity
type: Class
subclass of: protein tyrosine phosphatase activity
IAO_0000115: Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate.

prenylated protein tyrosine phosphatase activity
type: Class
subclass of: protein tyrosine phosphatase activity
IAO_0000115: Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate.

obsolete signal transducer, downstream of receptor, with protein tyrosine phosphatase activity
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

oxygen-dependent protoporphyrinogen oxidase activity
type: Class
subclass of: GO_0016634
subclass of: GO_0070818
IAO_0000115: Catalysis of the reaction: 3 O(2) + protoporphyrinogen IX = 3 H(2)O(2) + protoporphyrin IX.
has related synonym: protoporphyrinogen-IX:oxygen oxidoreductase activity

pseudouridylate synthase activity
type: Class
subclass of: GO_0016836
subclass of: part-of-parent-1522
IAO_0000115: Catalysis of the reaction: D-ribose 5-phosphate + uracil = H(2)O + pseudouridine 5'-phosphate.
has related synonym: 5-ribosyluracil 5-phosphate synthetase activity
has exact synonym: pseudouridine-5'-phosphate glycosidase activity
has exact synonym: pseudouridine monophosphate synthase activity
has related synonym: pseudouridine monophosphate synthetase activity
has related synonym: pseudouridylate synthetase activity
has related synonym: pseudouridylic acid synthetase activity
has related synonym: psiUMP synthetase activity
has related synonym: uracil hydro-lyase (adding D-ribose 5-phosphate; pseudouridine-5'-phosphate-forming)
has related synonym: uracil hydro-lyase (adding D-ribose 5-phosphate)
has related synonym: uracil hydrolyase activity

purine-nucleoside phosphorylase activity
type: Class
subclass of: GO_0016763
IAO_0000115: Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.
has related synonym: inosine-guanosine phosphorylase activity
has related synonym: inosine phosphorylase activity
has related synonym: PNPase activity
has related synonym: PUNPI
has related synonym: PUNPII
has related synonym: purine deoxynucleoside phosphorylase activity
has related synonym: purine deoxyribonucleoside phosphorylase activity
has related synonym: purine-nucleoside:phosphate ribosyltransferase activity
has related synonym: purine nucleoside phosphorylase activity
has related synonym: purine ribonucleoside phosphorylase activity

pyridoxal oxidase activity
type: Class
subclass of: GO_0016623
IAO_0000115: Catalysis of the reaction: pyridoxal + H2O + O2 = 4-pyridoxate + hydrogen peroxide.
has related synonym: pyridoxal:oxygen 4-oxidoreductase activity

pyridoxamine-phosphate oxidase activity
type: Class
subclass of: GO_0016641
subclass of: part-of-parent-42823
IAO_0000115: Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + hydrogen peroxide.
has related synonym: PdxH
has related synonym: PMP oxidase activity
has related synonym: pyridoxal 5'-phosphate synthase activity
has related synonym: pyridoxamine-5'-phosphate:oxygen oxidoreductase (deaminating)
has related synonym: pyridoxamine 5'-phosphate oxidase activity
has related synonym: pyridoxamine phosphate oxidase activity
has related synonym: pyridoxaminephosphate oxidase deaminating
has related synonym: pyridoxine (pyridoxamine) 5'-phosphate oxidase activity
has related synonym: pyridoxine (pyridoxamine)phosphate oxidase activity
has related synonym: pyridoxol-5'-phosphate:oxygen oxidoreductase (deaminating)

pyrimidodiazepine synthase activity
type: Class
subclass of: GO_0016648
IAO_0000115: Catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione.
has related synonym: PDA synthase activity
has related synonym: pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)

pyrroline-5-carboxylate reductase activity
type: Class
subclass of: GO_0016646
IAO_0000115: Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+.
has related synonym: 1-pyrroline-5-carboxylate reductase activity
has related synonym: L-proline:NAD(P)+ 5-oxidoreductase activity
has related synonym: L-proline-NAD(P)+ 5-oxidoreductase activity
has related synonym: L-proline oxidase activity
has related synonym: NADPH-L-delta1-pyrroline carboxylic acid reductase activity
has related synonym: P5CR activity

pyruvate carboxylase activity
type: Class
subclass of: GO_0016885
IAO_0000115: Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate.
has related synonym: pyruvate:carbon-dioxide ligase (ADP-forming)
has related synonym: pyruvic carboxylase activity

pyruvate decarboxylase activity
type: Class
subclass of: GO_0016831
IAO_0000115: Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2.
has related synonym: 2-oxo-acid carboxy-lyase (aldehyde-forming)
has related synonym: 2-oxo-acid carboxy-lyase activity
has related synonym: alpha-carboxylase activity
has related synonym: alpha-ketoacid carboxylase activity
has related synonym: pyruvic decarboxylase activity

pyruvate dehydrogenase activity
type: Class
subclass of: GO_0016903
IAO_0000115: Catalysis of the oxidative decarboxylation of pyruvate.
has related synonym: pyruvic acid dehydrogenase activity
has related synonym: pyruvic dehydrogenase activity

pyruvate dehydrogenase (acetyl-transferring) activity
type: Class
subclass of: pyruvate dehydrogenase activity
subclass of: GO_0016624
IAO_0000115: Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2.
has related synonym: MtPDC (mitochondrial pyruvate dehydogenase complex) activity
has related synonym: PDH
has related synonym: pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)
has related synonym: pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity
has exact synonym: pyruvate dehydrogenase (lipoamide) activity
has related synonym: pyruvate dehydrogenase complex activity

pyruvate dehydrogenase (acetyl-transferring) kinase activity
type: Class
subclass of: protein kinase activity
IAO_0000115: Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate.
has related synonym: PDHK
has related synonym: PDH kinase activity
has related synonym: PDK
has related synonym: pyruvate dehydrogenase kinase (phosphorylating) activity
has related synonym: pyruvate dehydrogenase kinase activity

[pyruvate dehydrogenase (lipoamide)] phosphatase activity
type: Class
subclass of: phosphoprotein phosphatase activity
IAO_0000115: Catalysis of the reaction: [pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [pyruvate dehydrogenase (lipoamide)] + phosphate.
has exact synonym: [pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic catalyst activity
has related synonym: phosphopyruvate dehydrogenase phosphatase activity
has exact synonym: pyruvate dehydrogenase (lipoamide) phosphatase activity
has related synonym: pyruvate dehydrogenase (lipoamide)-phosphatase activity
has related synonym: pyruvate dehydrogenase (lipoamide)-phosphate phosphohydrolase activity
has related synonym: pyruvate dehydrogenase phosphatase activity
replaces: GO_0019906

dihydrolipoyllysine-residue acetyltransferase activity
type: Class
subclass of: GO_0016418
subclass of: GO_0030523
subclass of: GO_0140096
IAO_0000115: Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide.
has related synonym: acetyl-CoA:dihydrolipoamide S-acetyltransferase activity
has related synonym: acetyl-CoA: enzyme-6-N-(dihydrolipoyl)lysine S-acetyltransferase activity
has related synonym: acetyl-CoA: enzyme-N6-(dihydrolipoyl)lysine S-acetyltransferase activity
has exact synonym: dihydrolipoamide S-acetyltransferase activity
has related synonym: dihydrolipoate acetyltransferase activity
has related synonym: dihydrolipoic transacetylase activity
has related synonym: dihydrolipoyl acetyltransferase activity
has related synonym: enzyme-dihydrolipoyllysine:acetyl-CoA S-acetyltransferase activity
has related synonym: lipoate acetyltransferase activity
has related synonym: lipoate transacetylase activity
has related synonym: lipoic acetyltransferase activity
has related synonym: lipoic acid acetyltransferase activity
has related synonym: lipoic transacetylase activity
has related synonym: lipoylacetyltransferase activity
has related synonym: thioltransacetylase A activity
has related synonym: transacetylase X activity

pyruvate kinase activity
type: Class
subclass of: GO_0016773
subclass of: part-of-parent-6096
IAO_0000115: Catalysis of the reaction: = ADP + H(+) + phosphoenolpyruvate => ATP + pyruvate.
has related synonym: ATP:pyruvate 2-O-phosphotransferase activity
has related synonym: phosphoenolpyruvate kinase activity
has related synonym: phosphoenol transphosphorylase activity

retinal isomerase activity
type: Class
subclass of: GO_0016859
IAO_0000115: Catalysis of the reaction: all-trans-retinal = 11-cis-retinal.
has related synonym: all-trans-retinal 11-cis-trans-isomerase activity
has related synonym: retinene isomerase activity
has related synonym: retinoid isomerase activity

NAD-retinol dehydrogenase activity
type: Class
subclass of: GO_0016616
IAO_0000115: Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+.
has related synonym: all-trans retinol dehydrogenase activity
has related synonym: retinal reductase activity
has related synonym: retinene reductase activity
has related synonym: retinol (vitamin A1) dehydrogenase activity
has related synonym: retinol dehydrogenase activity

riboflavin synthase activity
type: Class
subclass of: GO_0016765
IAO_0000115: Catalysis of the reaction: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-ribitylamino)uracil + riboflavin.
has related synonym: 6,7-dimethyl-8-(1-D-ribityl)lumazine:6,7-dimethyl-8-(1-D-ribityl)lumazine 2,3-butanediyltransferase activity
has related synonym: heavy riboflavin synthase
has related synonym: light riboflavin synthase
has related synonym: lumazine synthase activity
has related synonym: riboflavine synthase activity
has related synonym: riboflavine synthetase activity
has related synonym: riboflavin synthetase activity
has exact synonym: vitamin B2 synthase activity

ribokinase activity
type: Class
subclass of: GO_0016773
subclass of: GO_0019200
IAO_0000115: Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate.
has related synonym: ATP:D-ribose 5-phosphotransferase activity
has related synonym: deoxyribokinase activity
has related synonym: D-ribokinase activity
has related synonym: ribokinase (phosphorylating)

ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
type: Class
subclass of: GO_0061731
IAO_0000115: Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin.
has related synonym: 2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase activity
has related synonym: 2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase activity
replaces: GO_0016959
replaces: GO_0016960
replaces: GO_0016961

ribose phosphate diphosphokinase activity
type: Class
subclass of: GO_0016778
IAO_0000115: Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+).
has related synonym: 5-phosphoribose pyrophosphorylase activity
has related synonym: 5-phosphoribosyl-1-pyrophosphate synthetase activity
has related synonym: 5-phosphoribosyl-alpha-1-pyrophosphate synthetase activity
has related synonym: ATP:D-ribose-5-phosphate diphosphotransferase activity
has related synonym: phosphoribosyl diphosphate synthetase activity
has related synonym: phosphoribosyl-diphosphate synthetase activity
has related synonym: phosphoribosylpyrophosphate synthase activity
has related synonym: phosphoribosylpyrophosphate synthetase activity
has related synonym: phosphoribosyl pyrophosphate synthetase activity
has related synonym: PP-ribose P synthetase activity
has related synonym: PPRibP synthetase activity
has related synonym: PRPP synthetase activity
has related synonym: pyrophosphoribosylphosphate synthetase activity
has related synonym: ribophosphate pyrophosphokinase activity
has related synonym: ribose-5-phosphate pyrophosphokinase activity
has related synonym: ribose-phosphate diphosphokinase activity
has exact synonym: ribose-phosphate pyrophosphokinase activity

D-ribulose-phosphate 3-epimerase activity
type: Class
subclass of: GO_0016857
IAO_0000115: Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate.
has related synonym: D-ribulose-5-P 3-epimerase activity
has related synonym: D-ribulose-5-phosphate 3-epimerase activity
has related synonym: D-ribulose 5-phosphate epimerase activity
has related synonym: D-ribulose-5-phosphate epimerase activity
has related synonym: D-ribulose phosphate-3-epimerase activity
has related synonym: D-xylulose-5-phosphate 3-epimerase activity
has related synonym: erythrose-4-phosphate epimerase activity
has related synonym: erythrose-4-phosphate isomerase activity
has related synonym: pentose-5-phosphate 3-epimerase activity
has related synonym: pentose phosphate epimerase (PPE)
has related synonym: phosphoketopentose 3-epimerase activity
has related synonym: phosphoketopentose epimerase activity
has related synonym: phosphoribulose epimerase activity
has related synonym: ribulose 5-phosphate 3-epimerase activity
has related synonym: ribulose-phosphate 3-epimerase activity
has related synonym: xylulose phosphate 3-epimerase activity

ribose-5-phosphate isomerase activity
type: Class
subclass of: GO_0016861
IAO_0000115: Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate.
has exact synonym: 5-phosphoribose isomerase activity
has exact synonym: D-ribose-5-phosphate aldose-ketose-isomerase activity
has exact synonym: D-ribose 5-phosphate isomerase activity
has exact synonym: D-ribose-5-phosphate ketol-isomerase activity
has exact synonym: pentose phosphate isomerase (PPI)
has exact synonym: phosphopentoseisomerase activity
has exact synonym: phosphopentosisomerase activity
has exact synonym: phosphoriboisomerase activity
has exact synonym: ribose 5-phosphate epimerase activity
has exact synonym: ribose phosphate isomerase activity

saccharopine dehydrogenase activity
type: Class
subclass of: GO_0016646
IAO_0000115: Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor.
has related synonym: lysine-2-oxoglutarate reductase activity
has related synonym: lysine-ketoglutarate reductase activity

saccharopine dehydrogenase (NAD+, L-lysine-forming) activity
type: Class
subclass of: saccharopine dehydrogenase activity
IAO_0000115: Catalysis of the reaction: L-saccharopine + H(2)O + NAD(+) = 2-oxoglutarate + L-lysine + H(+) + NADH.
has related synonym: 6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)
has related synonym: dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming)
has related synonym: epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming)
has related synonym: N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming)
has related synonym: N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)

saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity
type: Class
subclass of: saccharopine dehydrogenase activity
IAO_0000115: Catalysis of the reaction: L-saccharopine + H(2)O + NADP(+) = L-allysine + L-glutamate + H(+) + NADPH.
has related synonym: 6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)
has related synonym: aminoadipate semialdehyde-glutamate reductase activity
has related synonym: aminoadipic semialdehyde-glutamate reductase activity
has related synonym: aminoadipic semialdehyde-glutamic reductase activity
has related synonym: epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreductase (L-2-aminoadipate-semialdehyde forming)
has related synonym: N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)
has related synonym: saccharopine (nicotinamide adenine dinucleotide phosphate, glutamate-forming) dehydrogenase activity
has related synonym: saccharopine reductase activity

selenide, water dikinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016781
IAO_0000115: Catalysis of the reaction: ATP + H(2)O + hydrogen selenide = AMP + 3 H(+) + phosphate + selenophosphorate.
has related synonym: ATP:selenide, water phosphotransferase activity
has related synonym: selenide,water dikinase activity
has related synonym: selenium donor protein activity
has exact synonym: selenophosphate synthase activity
has related synonym: selenophosphate synthetase activity

sepiapterin reductase activity
type: Class
subclass of: GO_0016616
IAO_0000115: Catalysis of the reaction: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+.
has related synonym: 7,8-dihydrobiopterin:NADP+ oxidoreductase activity

serine C-palmitoyltransferase activity
type: Class
subclass of: GO_0016454
IAO_0000115: Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA.
has related synonym: 3-oxosphinganine synthetase activity
has related synonym: acyl-CoA:serine C-2 acyltransferase decarboxylating
has related synonym: palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity
has related synonym: serine palmitoyltransferase
has related synonym: SPT

serine-pyruvate transaminase activity
type: Class
subclass of: GO_0008483
IAO_0000115: Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine.
has related synonym: hydroxypyruvate:L-alanine transaminase activity
has related synonym: L-serine:pyruvate aminotransferase activity
has related synonym: serine-pyruvate aminotransferase, type 1
has related synonym: serine-pyruvate aminotransferase, type 2A
has related synonym: serine-pyruvate aminotransferase, type 2B
has exact synonym: serine-pyruvate aminotransferase activity
has related synonym: serine--pyruvate aminotransferase activity
has related synonym: SPT
replaces: GO_0004761
replaces: GO_0004762
replaces: GO_0004763

shikimate 3-dehydrogenase (NADP+) activity
type: Class
subclass of: GO_0016616
IAO_0000115: Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+.
has related synonym: 5-dehydroshikimate reductase activity
has related synonym: 5-dehydroshikimic reductase activity
has related synonym: dehydroshikimic reductase activity
has related synonym: DHS reductase activity
has related synonym: shikimate:NADP(+) 5-oxidoreductase activity
has related synonym: shikimate:NADP(+) oxidoreductase activity
has related synonym: shikimate oxidoreductase activity

shikimate kinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016773
IAO_0000115: Catalysis of the reaction: ATP + shikimate = 3-phosphoshikimate + ADP + 2 H(+).
has related synonym: ATP:shikimate 3-phosphotransferase activity
has related synonym: shikimate kinase (phosphorylating)
has related synonym: shikimate kinase II

spermidine synthase activity
type: Class
subclass of: GO_0016765
IAO_0000115: Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine.
has related synonym: aminopropyltransferase activity
has related synonym: putrescine aminopropyltransferase activity
has related synonym: S-adenosylmethioninamine:putrescine 3-aminopropyltransferase activity
has related synonym: SpeE
has related synonym: spermidine synthetase activity

sphingomyelin phosphodiesterase activity
type: Class
subclass of: phospholipase activity
subclass of: GO_0008081
IAO_0000115: Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+).
has exact synonym: sphingomyelinase activity
has related synonym: sphingomyelin cholinephosphohydrolase activity
replaces: GO_0030230
replaces: GO_0030231

stearoyl-CoA 9-desaturase activity
type: Class
subclass of: GO_0016215
IAO_0000115: Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O.
has related synonym: acyl-CoA desaturase
has related synonym: delta(9)-desaturase activity
has related synonym: delta9-desaturase
has related synonym: fatty acid desaturase
has related synonym: stearoyl-CoA desaturase activity
replaces: GO_0016214
replaces: GO_0043735

steroid delta-isomerase activity
type: Class
subclass of: GO_0016863
IAO_0000115: Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid.
has related synonym: 3-oxosteroid delta5-delta4-isomerase activity
has related synonym: 3-oxosteroid isomerase activity
has related synonym: delta(5)-3-ketosteroid isomerase activity
has related synonym: delta(5)-3-keto steroid isomerase activity
has related synonym: delta(5)-3-oxosteroid isomerase activity
has related synonym: delta(5)-steroid isomerase activity
has related synonym: delta5(or delta4)-3-keto steroid isomerase activity
has related synonym: delta5-3-ketosteroid isomerase activity
has related synonym: delta5-3-keto steroid isomerase activity
has related synonym: delta5-3-oxosteroid isomerase activity
has related synonym: delta5-ketosteroid isomerase activity
has related synonym: delta5-steroid isomerase activity
has related synonym: hydroxysteroid isomerase activity
has exact synonym: steroid D-isomerase activity
has related synonym: steroid isomerase activity

sterol esterase activity
type: Class
subclass of: GO_0016298
subclass of: GO_0052689
IAO_0000115: Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid.
has related synonym: acylcholesterol lipase activity
has related synonym: cholesterase activity
has related synonym: cholesterol esterase activity
has related synonym: cholesterol ester hydrolase activity
has related synonym: cholesterol ester synthase activity
has related synonym: cholesteryl esterase activity
has related synonym: cholesteryl ester hydrolase activity
has related synonym: cholesteryl ester synthase activity
has related synonym: sterol ester hydrolase activity
has related synonym: steryl-ester acylhydrolase activity
has related synonym: triterpenol esterase activity

sterol O-acyltransferase activity
type: Class
subclass of: GO_0008374
IAO_0000115: Catalysis of the reaction: acyl-CoA + a sterol = CoA + a sterol ester.
has related synonym: sterol-ester synthase activity
has related synonym: sterol-ester synthetase activity
replaces: GO_0017066

steryl-sulfatase activity
type: Class
subclass of: GO_0008484
IAO_0000115: Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate.
has related synonym: 3-beta-hydroxysteroid sulfate sulfatase activity
has related synonym: arylsulfatase C activity
has related synonym: dehydroepiandrosterone sulfatase activity
has related synonym: dehydroepiandrosterone sulfate sulfatase activity
has related synonym: phenolic steroid sulfatase activity
has related synonym: pregnenolone sulfatase activity
has related synonym: steroid 3-sulfatase activity
has related synonym: steroid sulfatase activity
has related synonym: steroid sulfate sulfohydrolase activity
has related synonym: sterol sulfatase activity
has related synonym: steryl-sulfate sulfohydrolase activity
has exact synonym: steryl-sulphatase activity

succinate-CoA ligase activity
type: Class
subclass of: GO_0016878
IAO_0000115: Catalysis of the reaction: succinate + CoA + nucleotide triphosphate = nucleotide diphosphate + phosphate + succinyl-CoA.

succinate-CoA ligase (ADP-forming) activity
type: Class
subclass of: succinate-CoA ligase activity
IAO_0000115: Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate.
has related synonym: succinate thiokinase activity
has related synonym: succinic thiokinase
has related synonym: succinyl-CoA synthetase (ADP-forming) activity
has related synonym: succinyl-CoA synthetase activity
has related synonym: succinyl coenzyme A synthetase
has related synonym: succinyl coenzyme A synthetase (adenosine diphosphate-forming) activity

succinate-CoA ligase (GDP-forming) activity
type: Class
subclass of: succinate-CoA ligase activity
IAO_0000115: Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate.
has related synonym: succinate:CoA ligase (GDP-forming) activity
has related synonym: succinyl-CoA synthetase (GDP-forming) activity
has related synonym: succinyl CoA synthetase activity
has related synonym: succinyl coenzyme A synthetase
has related synonym: succinyl coenzyme A synthetase (GDP-forming) activity
has related synonym: succinyl coenzyme A synthetase (guanosine diphosphate-forming) activity

succinate-semialdehyde dehydrogenase (NAD+) activity
type: Class
subclass of: GO_0009013
IAO_0000115: Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+.
has related synonym: succinate semialdehyde:NAD+ oxidoreductase activity
has related synonym: succinate-semialdehyde:NAD+ oxidoreductase activity
has related synonym: succinate semialdehyde dehydrogenase activity
has related synonym: succinate-semialdehyde dehydrogenase activity
has related synonym: succinic semialdehyde dehydrogenase activity
has related synonym: succinyl semialdehyde dehydrogenase activity
replaces: GO_0008952

succinyl-CoA hydrolase activity
type: Class
subclass of: GO_0016289
IAO_0000115: Catalysis of the reaction: H(2)O + succinyl-CoA = CoA + H(+) + succinate.
has related synonym: succinyl-CoA acylase activity
has related synonym: succinyl coenzyme A deacylase activity
has related synonym: succinyl coenzyme A hydrolase activity

sulfate adenylyltransferase activity
type: Class
subclass of: GO_0070566
IAO_0000115: Catalysis of the transfer of an adenylyl group from an adenosine nucleotide (ATP or ADP) to sulfate, forming adenylylsulfate.
has exact synonym: sulphate adenylyltransferase activity

sulfate adenylyltransferase (ADP) activity
type: Class
subclass of: sulfate adenylyltransferase activity
IAO_0000115: Catalysis of the reaction: ADP + H(+) + sulfate = 5'-adenylyl sulfate + phosphate.
has related synonym: adenosine diphosphate sulfurylase activity
has exact synonym: ADP:sulfate adenylyltransferase activity
has related synonym: ADP-sulfurylase activity
has related synonym: sulfate (adenosine diphosphate) adenylyltransferase activity
has exact synonym: sulphate adenylyltransferase (ADP) activity

sulfate adenylyltransferase (ATP) activity
type: Class
subclass of: sulfate adenylyltransferase activity
IAO_0000115: Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate.
has related synonym: adenosine-5'-triphosphate sulfurylase activity
has related synonym: adenosinetriphosphate sulfurylase activity
has related synonym: adenylylsulfate pyrophosphorylase activity
has exact synonym: ATP:sulfate adenylyltransferase activity
has related synonym: ATP sulfurylase activity
has related synonym: ATP-sulfurylase activity
has related synonym: sulfate adenylate transferase activity
has related synonym: sulfurylase activity
has exact synonym: sulphate adenylyltransferase (ATP) activity

sulfinoalanine decarboxylase activity
type: Class
subclass of: GO_0016831
IAO_0000115: Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2.
has related synonym: 3-sulfino-L-alanine carboxy-lyase (hypotaurine-forming)
has related synonym: 3-sulfino-L-alanine carboxy-lyase activity
has related synonym: CADCase/CSADCase activity
has related synonym: CSAD
has related synonym: CSADCase activity
has related synonym: cysteic decarboxylase activity
has related synonym: cysteinesulfinate decarboxylase activity
has related synonym: cysteine-sulfinate decarboxylase activity
has related synonym: cysteinesulfinic acid decarboxylase activity
has related synonym: L-cysteinesulfinic acid decarboxylase activity
has related synonym: sulfoalanine decarboxylase activity
has exact synonym: sulphinoalanine decarboxylase activity

sulfite reductase (NADPH) activity
type: Class
subclass of: GO_0016002
subclass of: GO_0016668
IAO_0000115: Catalysis of the reaction: hydrogen sulfide + 3 NADP+ + 3 H2O = sulfite + 3 NADPH + 3 H+.
has related synonym: H2S-NADP oxidoreductase activity
has related synonym: hydrogen-sulfide:NADP+ oxidoreductase activity
has related synonym: NADPH:sulfite reductase flavoprotein
has related synonym: NADPH-dependent sulfite reductase activity
has related synonym: NADPH-sulfite reductase activity
has related synonym: sulfite (reduced nicotinamide adenine dinucleotide phosphate) reductase activity
has exact synonym: sulphite reductase (NADPH) activity

superoxide dismutase activity
type: Class
subclass of: GO_0016209
subclass of: GO_0016721
subclass of: part-of-parent-19430
IAO_0000115: Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide.
has related synonym: copper, zinc superoxide dismutase activity
has related synonym: Cu,Zn-SOD
has related synonym: cuprein
has related synonym: Cu-Zn superoxide dismutase activity
has related synonym: cytocuprein
has related synonym: erythrocuprein
has related synonym: ferrisuperoxide dismutase activity
has related synonym: Fe-SOD
has related synonym: hemocuprein
has related synonym: hepatocuprein
has related synonym: iron superoxide dismutase activity
has related synonym: iron superoxide oxidoreductase
has related synonym: manganese superoxide dismutase activity
has related synonym: manganese superoxide oxidoreductase
has related synonym: Mn, Fe superoxide dismutase
has related synonym: Mn-SOD
has related synonym: nickel superoxide dismutase activity
has related synonym: nickel superoxide oxidoreductase
has related synonym: SOD
has related synonym: SOD-1
has related synonym: SOD-2
has related synonym: SOD-3
has related synonym: SOD-4
has related synonym: SODF
has related synonym: SODS
has exact synonym: superoxide:superoxide oxidoreductase activity
has related synonym: superoxide dismutase I
has related synonym: superoxide dismutase II
has related synonym: zinc superoxide oxidoreductase
replaces: GO_0004785
replaces: GO_0008382
replaces: GO_0008383
replaces: GO_0016954

obsolete Mn, Fe superoxide dismutase
type: Class
subclass of: ObsoleteClass
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).

thiamine diphosphate phosphatase activity
type: Class
subclass of: GO_0016462
IAO_0000115: Catalysis of the reaction: thiamine diphosphate + H2O = thiamine monophosphate + phosphate.
has related synonym: thiamine diphosphatase activity
has exact synonym: thiamine-diphosphatase activity
has exact synonym: thiamine pyrophosphatase activity
has related synonym: thiaminpyrophosphatase activity
has exact synonym: thiamin pyrophosphatase activity
has exact synonym: thiamin-pyrophosphatase activity
has exact synonym: TPPase activity

thiamine diphosphokinase activity
type: Class
subclass of: GO_0016778
IAO_0000115: Catalysis of the reaction: ATP + thiamine = AMP + thiamine diphosphate.
has related synonym: ATP:thiamine diphosphotransferase activity
has related synonym: ATP:thiamin pyrophosphotransferase activity
has related synonym: thiamin:ATP pyrophosphotransferase activity
has exact synonym: thiamin diphosphokinase activity
has exact synonym: thiamine pyrophosphokinase activity
has related synonym: thiaminokinase activity
has exact synonym: thiamin pyrophosphokinase activity
has related synonym: thiamin pyrophosphotransferase activity
has related synonym: TPTase activity

thiamine-phosphate diphosphorylase activity
type: Class
subclass of: GO_0016765
IAO_0000115: Catalysis of the reaction: 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-(2-phosphoethyl)-thiazole + H(+) = diphosphate + thiamine phosphate.
has related synonym: 2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)thiazole 2-methyl-4-aminopyrimidine-5-methenyltransferase activity
has related synonym: thiamine monophosphate pyrophosphorylase activity
has related synonym: thiamine phosphate pyrophosphorylase activity
has exact synonym: thiamine-phosphate pyrophosphorylase activity
has related synonym: thiamine-phosphate synthase activity
has exact synonym: thiamin-phosphate diphosphorylase activity
has exact synonym: thiamin-phosphate pyrophosphorylase activity
has related synonym: TMP diphosphorylase activity
has related synonym: TMP-PPase activity
has related synonym: TMP pyrophosphorylase activity

thioether S-methyltransferase activity
type: Class
subclass of: GO_0008172
subclass of: GO_0008757
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine(1+) + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium.
has related synonym: S-adenosyl-L-methionine:dimethyl-sulfide S-methyltransferase activity
has related synonym: S-adenosyl-L-methionine:thioether S-methyltransferase activity
has related synonym: thioether methyltransferase activity

thioredoxin-disulfide reductase activity
type: Class
subclass of: GO_0016209
subclass of: GO_0047134
IAO_0000115: Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide.
has related synonym: NADPH:oxidized thioredoxin oxidoreductase activity
has related synonym: NADPH2:oxidized thioredoxin oxidoreductase activity
has related synonym: NADPH--thioredoxin reductase activity
has related synonym: NADP--thioredoxin reductase activity
has related synonym: thioredoxin:NADP+ oxidoreductase activity
has exact synonym: thioredoxin disulfide reductase activity
has exact synonym: thioredoxin-disulphide reductase activity
has exact synonym: thioredoxin reductase (NADPH) activity

thiosulfate sulfurtransferase activity
type: Class
subclass of: GO_0016783
IAO_0000115: Catalysis of the reaction: hydrogen cyanide + thiosulfate = H(+) + sulfite + thiocyanate.
has related synonym: rhodanase activity
has related synonym: rhodanese activity
has related synonym: thiosulfate:cyanide sulfurtransferase activity
has related synonym: thiosulfate cyanide transsulfurase activity
has related synonym: thiosulfate thiotransferase activity
has exact synonym: thiosulphate sulphurtransferase activity

threonine aldolase activity
type: Class
subclass of: GO_0016832
IAO_0000115: Catalysis of the reaction: L-threonine = glycine + acetaldehyde.
has related synonym: L-threonine acetaldehyde-lyase (glycine-forming)
has related synonym: L-threonine acetaldehyde-lyase activity
has exact synonym: L-threonine aldolase activity

L-threonine ammonia-lyase activity
type: Class
subclass of: GO_0016841
IAO_0000115: Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3.
has related synonym: L-serine dehydratase activity
has related synonym: L-threonine ammonia-lyase (2-oxobutanoate-forming)
has related synonym: L-threonine deaminase activity
has related synonym: L-threonine dehydratase activity
has related synonym: L-threonine hydro-lyase (deaminating) activity
has related synonym: serine deaminase activity
has exact synonym: threonine ammonia-lyase activity
has related synonym: threonine deaminase activity
has related synonym: threonine dehydrase activity
has exact synonym: threonine dehydratase activity

threonine synthase activity
type: Class
subclass of: GO_0016838
IAO_0000115: Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate.
has related synonym: O-phospho-L-homoserine phospho-lyase (adding water; L-threonine-forming)
has related synonym: O-phospho-L-homoserine phospho-lyase (adding water)
has related synonym: threonine synthetase activity

thromboxane-A synthase activity
type: Class
subclass of: GO_0016860
IAO_0000115: Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2).
has related synonym: (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase activity
has related synonym: (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase activity
has related synonym: cytochrome P450 CYP5
has related synonym: thromboxane synthase activity
has related synonym: thromboxane synthetase activity
replaces: GO_0008400

thymidine kinase activity
type: Class
subclass of: GO_0019136
IAO_0000115: Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate.
has related synonym: 2'-deoxythymidine kinase activity
has related synonym: ATP:thymidine 5'-phosphotransferase activity
has related synonym: deoxythymidine kinase (phosphorylating)
has related synonym: thymidine kinase (phosphorylating)

thymidylate kinase activity
type: Class
subclass of: GO_0050145
IAO_0000115: Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate.
has related synonym: ATP:dTMP phosphotransferase activity
has related synonym: deoxythymidine 5'-monophosphate kinase activity
has exact synonym: dTMP kinase activity
has related synonym: thymidine 5'-monophosphate kinase activity
has related synonym: thymidine monophosphate kinase activity
has related synonym: thymidylate monophosphate kinase activity
has related synonym: thymidylic acid kinase activity
has related synonym: thymidylic kinase activity
has related synonym: TMPK activity

thymidylate synthase activity
type: Class
subclass of: GO_0042083
IAO_0000115: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate.
has related synonym: 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase activity
has related synonym: dTMP synthase activity
has related synonym: methylenetetrahydrofolate:dUMP C-methyltransferase activity
has related synonym: thymidylate synthetase activity
has related synonym: TMP synthetase activity

thyroxine 5'-deiodinase activity
type: Class
subclass of: GO_0016491
IAO_0000115: Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2.
has related synonym: acceptor:3,5,3'-triiodo-L-thyronine oxidoreductase (iodinating)
has related synonym: diiodothyronine 5'-deiodinase activity
has related synonym: iodothyronine 5'-deiodinase activity
has related synonym: iodothyronine outer ring monodeiodinase activity
has related synonym: L-thyroxine iodohydrolase (reducing) activity
has exact synonym: outer ring-deiodinating pathway
has exact synonym: thyroxine 5' deiodinase activity
has related synonym: thyroxine deiodinase activity
has related synonym: type II iodothyronine deiodinase activity
has related synonym: type I iodothyronine deiodinase activity

transaldolase activity
type: Class
subclass of: GO_0016744
IAO_0000115: Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.
has related synonym: dihydroxyacetonetransferase activity
has related synonym: dihydroxyacetone transferase activity
has related synonym: glycerone transferase activity
has exact synonym: sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity

transketolase activity
type: Class
subclass of: GO_0016744
IAO_0000115: Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor.
has related synonym: fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity
has related synonym: glycoaldehyde transferase activity
has related synonym: glycolaldehydetransferase activity
has related synonym: sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity

transposase activity
type: Class
subclass of: GO_0140097
IAO_0000115: Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element.
has related synonym: P-element encoded transposase activity
replaces: GO_0004804

trehalose-phosphatase activity
type: Class
subclass of: GO_0019203
IAO_0000115: Catalysis of the reaction: trehalose 6-phosphate + H2O = trehalose + phosphate.
has related synonym: trehalose 6-phosphatase activity
has related synonym: trehalose 6-phosphate phosphatase activity
has related synonym: trehalose-6-phosphate phosphohydrolase activity
has exact synonym: trehalose phosphatase activity

triglyceride lipase activity
type: Class
subclass of: GO_0016298
subclass of: GO_0052689
IAO_0000115: Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.
has related synonym: amano AP
has related synonym: amano B
has related synonym: amano CE
has related synonym: amano CES
has related synonym: amano P
has related synonym: amno N-AP
has related synonym: butyrinase activity
has related synonym: cacordase activity
has related synonym: capalase L
has related synonym: GA 56
has related synonym: GEH
has related synonym: glycerol ester hydrolase activity
has related synonym: glycerol-ester hydrolase activity
has related synonym: heparin releasable hepatic lipase
has related synonym: hepatic lipase
has related synonym: hepatic monoacylglycerol acyltransferase
has related synonym: lipazin
has related synonym: liver lipase
has related synonym: meito MY 30
has related synonym: meito sangyo OF lipase
has related synonym: post-heparin plasma protamine-resistant lipase
has related synonym: PPL
has related synonym: salt-resistant post-heparin lipase
has related synonym: steapsin
has exact synonym: TAG activity
has related synonym: takedo 1969-4-9
has related synonym: triacetinase activity
has related synonym: triacylglycerol acylhydrolase activity
has related synonym: triacylglycerol ester hydrolase activity
has related synonym: triacylglycerol lipase activity
has related synonym: tributyrase activity
has related synonym: tributyrinase activity
has related synonym: tributyrin esterase activity
has related synonym: triglyceridase activity
has related synonym: triglyceride hydrolase activity
has related synonym: triolein hydrolase activity
has related synonym: tweenase activity
has related synonym: tweenesterase activity
has related synonym: tween hydrolase activity
has related synonym: tween-hydrolyzing esterase activity

triose-phosphate isomerase activity
type: Class
subclass of: GO_0016861
IAO_0000115: Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate.
has related synonym: D-glyceraldehyde-3-phosphate aldose-ketose-isomerase activity
has related synonym: D-glyceraldehyde-3-phosphate ketol-isomerase activity
has related synonym: phosphotriose isomerase activity
has related synonym: triosephosphate isomerase activity
has related synonym: triosephosphate mutase activity
has related synonym: triose phosphate mutase activity
has related synonym: triose phosphoisomerase activity

tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
type: Class
subclass of: GO_0008175
subclass of: GO_0008757
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing 5-aminomethyl-2-thiouridine = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate.
has related synonym: S-adenosyl-L-methionine:tRNA (5-methylaminomethyl-2-thio-uridylate)-methyltransferase activity
has related synonym: transfer ribonucleate 5-methylaminomethyl-2-thiouridylate 5-methyltransferase activity
has related synonym: tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase activity
replaces: GO_0016425

tRNA (guanine-N2-)-methyltransferase activity
type: Class
subclass of: GO_0008170
subclass of: GO_0016423
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine.
has related synonym: guanine-N2-methylase activity
has related synonym: N(2),N(2)-dimethylguanine tRNA methyltransferase activity
has related synonym: N2,N2-dimethylguanine tRNA methyltransferase activity
has related synonym: S-adenosyl-L-methionine:tRNA (guanine-2-N-)-methyltransferase activity
has related synonym: S-adenosyl-L-methionine:tRNA (guanine-N2-)-methyltransferase activity
has related synonym: transfer ribonucleate guanine 2-methyltransferase activity
has related synonym: transfer ribonucleate guanine N2-methyltransferase activity
has related synonym: transfer RNA guanine 2-methyltransferase activity
has related synonym: tRNA(guanine-26,N(2)-N(2)) methyltransferase activity
has related synonym: tRNA(guanine-26,N2-N2) methyltransferase activity
has related synonym: tRNA(m(2,2)G26)dimethyltransferase activity
has related synonym: tRNA 2,2-dimethylguanosine-26 methyltransferase activity

tRNA adenylyltransferase activity
type: Class
subclass of: GO_1990817
IAO_0000115: Catalysis of the reaction: ATP + tRNA(n) = diphosphate + tRNA(n+1).
has exact synonym: ATP:tRNA adenylyltransferase activity
has related synonym: ATP (CTP):tRNA nucleotidyltransferase
has related synonym: ATP(CTP)-tRNA nucleotidyltransferase
has related synonym: CCA-adding enzyme activity
has related synonym: -C-C-A pyrophosphorylase
has related synonym: CTP(ATP):tRNA nucleotidyltransferase
has related synonym: ribonucleic cytidylic cytidylic adenylic pyrophosphorylase
has related synonym: ribonucleic cytidylyltransferase
has related synonym: transfer ribonucleate adenyltransferase activity
has related synonym: transfer ribonucleate adenylyltransferase
has related synonym: transfer ribonucleate cytidylyltransferase
has related synonym: transfer ribonucleate nucleotidyltransferase
has related synonym: transfer ribonucleic acid nucleotidyl transferase
has related synonym: transfer ribonucleic adenylyl (cytidylyl) transferase
has related synonym: transfer ribonucleic-terminal trinucleotide nucleotidyltransferase
has related synonym: transfer RNA adenylyltransferase
has related synonym: transfer-RNA nucleotidyltransferase
has related synonym: tRNA adenylyl(cytidylyl)transferase
has related synonym: tRNA CCA-diphosphorylase activity
has related synonym: tRNA CCA-pyrophosphorylase activity
has related synonym: tRNA-nucleotidyltransferase activity

aminoacyl-tRNA ligase activity
type: Class
subclass of: GO_0016875
subclass of: GO_0140101
IAO_0000115: Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP.
has exact synonym: aminoacyl-tRNA synthetase activity
has related synonym: aminoacyl-tRNA synthetase auxiliary protein activity
has related synonym: ligase activity, forming aminoacyl-tRNA and related compounds
replaces: GO_0016876
replaces: GO_0017100

alanine-tRNA ligase activity
type: Class
subclass of: aminoacyl-tRNA ligase activity
IAO_0000115: Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
has related synonym: alanine-transfer RNA ligase activity
has related synonym: alanine transfer RNA synthetase activity
has related synonym: alanine translase activity
has related synonym: alanine tRNA synthetase activity
has related synonym: alanyl-transfer ribonucleate synthase activity
has related synonym: alanyl-transfer ribonucleate synthetase activity
has related synonym: alanyl-transfer ribonucleic acid synthetase activity
has related synonym: alanyl-transfer RNA synthetase activity
has exact synonym: alanyl-tRNA synthetase activity
has related synonym: AlaRS
has related synonym: Ala-tRNA synthetase activity
has related synonym: L-alanine:tRNAAla ligase (AMP-forming)

arginine-tRNA ligase activity
type: Class
subclass of: aminoacyl-tRNA ligase activity
IAO_0000115: Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).
has related synonym: arginine translase activity
has related synonym: arginine-tRNA synthetase activity
has related synonym: arginyl-transfer ribonucleate synthetase activity
has related synonym: arginyl transfer ribonucleic acid synthetase activity
has related synonym: arginyl-transfer RNA synthetase activity
has exact synonym: arginyl-tRNA synthetase activity
has related synonym: L-arginine:tRNAArg ligase (AMP-forming)

aspartate-tRNA ligase activity
type: Class
subclass of: aminoacyl-tRNA ligase activity
IAO_0000115: Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp).
has related synonym: aspartic acid translase activity
has related synonym: aspartyl ribonucleate synthetase activity
has related synonym: aspartyl ribonucleic synthetase activity
has related synonym: aspartyl-transfer ribonucleic acid synthetase activity
has related synonym: aspartyl-transfer RNA synthetase activity
has exact synonym: aspartyl-tRNA synthetase activity
has related synonym: L-aspartate:tRNAAsp ligase (AMP-forming)

asparagine-tRNA ligase activity
type: Class
subclass of: aminoacyl-tRNA ligase activity
IAO_0000115: Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H(+).
has related synonym: asparagine translase activity
has related synonym: asparaginyl-transfer ribonucleate synthetase activity
has related synonym: asparaginyl transfer ribonucleic acid synthetase activity
has related synonym: asparaginyl transfer RNA synthetase activity
has exact synonym: asparaginyl-tRNA synthetase activity
has related synonym: asparagyl-transfer RNA synthetase activity
has related synonym: L-asparagine:tRNAAsn ligase (AMP-forming)

cysteine-tRNA ligase activity
type: Class
subclass of: aminoacyl-tRNA ligase activity
IAO_0000115: Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).
has related synonym: cysteine translase activity
has related synonym: cysteinyl-transfer ribonucleate synthetase activity
has related synonym: cysteinyl-transferRNA synthetase activity
has exact synonym: cysteinyl-tRNA synthetase activity
has related synonym: L-cysteine:tRNACys ligase (AMP-forming)

glutamate-tRNA ligase activity
type: Class
subclass of: aminoacyl-tRNA ligase activity
IAO_0000115: Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).
has related synonym: glutamate-tRNA synthetase activity
has related synonym: glutamic acid translase activity
has related synonym: glutamyl-transfer ribonucleate synthetase activity
has related synonym: glutamyl-transfer ribonucleic acid synthetase activity
has related synonym: glutamyl-transfer RNA synthetase activity
has exact synonym: glutamyl-tRNA synthetase activity
has related synonym: L-glutamate:tRNAGlu ligase (AMP-forming) activity

glutamine-tRNA ligase activity
type: Class
subclass of: aminoacyl-tRNA ligase activity
IAO_0000115: Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).
has related synonym: GlnRS
has related synonym: glutamine translase activity
has related synonym: glutamine-tRNA synthetase activity
has related synonym: glutaminyl ribonucleic acid
has related synonym: glutaminyl-transfer ribonucleate synthetase activity
has related synonym: glutaminyl-transfer RNA synthetase activity
has exact synonym: glutaminyl-tRNA synthetase activity
has related synonym: L-glutamine:tRNAGln ligase (AMP-forming)

glycine-tRNA ligase activity
type: Class
subclass of: aminoacyl-tRNA ligase activity
IAO_0000115: Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly).
has related synonym: glycine:tRNAGly ligase (AMP-forming) activity
has related synonym: glycyl-transfer ribonucleate synthetase activity
has related synonym: glycyl-transfer ribonucleic acid synthetase activity
has related synonym: glycyl-transfer RNA synthetase activity
has related synonym: glycyl translase activity
has exact synonym: glycyl-tRNA synthetase activity

histidine-tRNA ligase activity
type: Class
subclass of: aminoacyl-tRNA ligase activity
IAO_0000115: Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).
has related synonym: histidine translase activity
has related synonym: histidyl-transfer ribonucleate synthetase activity
has exact synonym: histidyl-tRNA synthetase activity
has related synonym: L-histidine:tRNAHis ligase (AMP-forming)

isoleucine-tRNA ligase activity
type: Class
subclass of: aminoacyl-tRNA ligase activity
IAO_0000115: Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+).
has related synonym: isoleucine-transfer RNA ligase activity
has related synonym: isoleucine translase activity
has related synonym: isoleucine-tRNA synthetase activity
has related synonym: isoleucyl-transfer ribonucleate synthetase activity
has related synonym: isoleucyl-transfer RNA synthetase activity
has exact synonym: isoleucyl-tRNA synthetase activity
has related synonym: L-isoleucine:tRNAIle ligase (AMP-forming)

leucine-tRNA ligase activity
type: Class
subclass of: aminoacyl-tRNA ligase activity
IAO_0000115: Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu).
has related synonym: leucine translase activity
has related synonym: leucine-tRNA synthetase activity
has related synonym: leucyl-transfer ribonucleate synthetase activity
has related synonym: leucyl-transfer ribonucleic acid synthetase activity
has related synonym: leucyl-transfer RNA synthetase activity
has exact synonym: leucyl-tRNA synthetase activity
has related synonym: L-leucine:tRNALeu ligase (AMP-forming)

lysine-tRNA ligase activity
type: Class
subclass of: aminoacyl-tRNA ligase activity
IAO_0000115: Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).
has related synonym: L-lysine:tRNALys ligase (AMP-forming)
has related synonym: L-lysine-transfer RNA ligase activity
has related synonym: lysine translase activity
has related synonym: lysine-tRNA synthetase activity
has related synonym: lysyl-transfer ribonucleate synthetase activity
has related synonym: lysyl-transfer RNA synthetase activity
has exact synonym: lysyl-tRNA synthetase activity

methionine-tRNA ligase activity
type: Class
subclass of: aminoacyl-tRNA ligase activity
IAO_0000115: Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).
has related synonym: L-methionine:tRNAMet ligase (AMP-forming)
has related synonym: methionine translase activity
has related synonym: methionyl-transfer ribonucleate synthetase activity
has related synonym: methionyl-transfer ribonucleic acid synthetase activity
has related synonym: methionyl-transfer RNA synthetase activity
has exact synonym: methionyl-tRNA synthetase activity
has related synonym: MetRS activity

phenylalanine-tRNA ligase activity
type: Class
subclass of: aminoacyl-tRNA ligase activity
IAO_0000115: Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).
has related synonym: L-phenylalanine:tRNAPhe ligase (AMP-forming) activity
has related synonym: L-phenylalanyl-tRNA synthetase activity
has related synonym: phenylalanine translase activity
has related synonym: phenylalanine-tRNA synthetase activity
has related synonym: phenylalanyl-transfer ribonucleate synthetase activity
has related synonym: phenylalanyl-transfer RNA ligase activity
has related synonym: phenylalanyl-transfer RNA synthetase activity
has related synonym: phenylalanyl-tRNA ligase activity
has exact synonym: phenylalanyl-tRNA synthetase activity