NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) ALONE AND IN COMPLEX WITH RABBIT ACTIN
Binds to actin and affects the structure of the cytoskeleton. At high concentrations inhibits spontaneous rabbit actin nucleation. This strongly suggests this archaea has a profilin-regulated actin system, and actin-type genes can be identified in this organism.
Inhibition of rabbit actin polymerization is reduced by phosphatidylinositol-(4,5)-P2(1,2-dipalmitoyl), a soluble form of the phospholipid phosphatidylinositol, suggesting an unknown lipid might regulate actin-profilin interaction in vivo.
The Loki loop (specific to some members) becomes ordered on binding to rabbit actin.
It is not clear if Loki profilins 1, 2 and 3 are from the same strain.
X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) IN COMPLEX WITH RABBIT ACTIN
X-RAY CRYSTALLOGRAPHY (1.53 ANGSTROMS) IN COMPLEX WITH RABBIT ACTIN
Has no profilin activity against rabbit actin.