Q8RG99
type: Protein
reviewed: true
created: 2006-02-21
modified: 2023-02-22
version: 108
mnemonic: ACCA_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIPD345ED6FED4C7897
enzyme: http://purl.uniprot.org/enzyme/2.1.3.15
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIP1107C85C7813DEC9
annotation: SIPEECEAB02B7BFBB26
annotation: SIP78B047417C2AF437
annotation: SIP2A01F1F71E06A6C1
annotation: SIP6826DDE26DC5F7C8
annotation: SIP92423756C9DBEFDC
annotation: PRO_0000223770
annotation: SIPDE4E1794C2654E60
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/275
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/808
classified with: GO_0009317
classified with: GO_0003989
classified with: GO_0005524
classified with: GO_0016743
classified with: GO_0006633
classified with: GO_2001295
sequence: Q8RG99-1
proteome: Chromosome

Q8RG99-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG0825
type: Resource
database: eggNOG
comment: Bacteria

MF_00823
type: Resource
database: HAMAP
comment: AcetylCoA_CT_alpha
signature sequence match: HAMAP MF 00823 match 1

IPR001095
type: Resource
database: InterPro
comment: Acetyl_CoA_COase_a_su

IPR029045
type: Resource
database: InterPro
comment: ClpP/crotonase-like_dom_sf

IPR011763
type: Resource
database: InterPro
comment: COA_CT_C

PTHR42853
type: Resource
database: PANTHER
comment: ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE SUBUNIT ALPHA
signature sequence match: PANTHER PTHR42853 match 1

PTHR42853:SF3
type: Resource
database: PANTHER
comment: ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE SUBUNIT ALPHA, CHLOROPLASTIC
signature sequence match: PANTHER PTHR42853:SF3 match 1

PF03255
type: Resource
database: Pfam
comment: ACCA
signature sequence match: Pfam PF03255 match 1

PR01069
type: Resource
database: PRINTS
comment: ACCCTRFRASEA

SSF52096
type: Resource
database: SUPFAM
comment: ClpP/crotonase
signature sequence match: SUPFAM SSF52096 match 1
signature sequence match: SUPFAM SSF52096 match 2

TIGR00513
type: Resource
database: TIGRFAMs
comment: accA
signature sequence match: TIGRFAMs TIGR00513 match 1

PS50989
type: Resource
database: PROSITE
comment: COA_CT_CTER
signature sequence match: PROSITE PS50989 match 1

SIPD345ED6FED4C7897
type: Structured Name
full name: Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
short name: ACCase subunit alpha
short name: Acetyl-CoA carboxylase carboxyltransferase subunit alpha
ec name: 2.1.3.15

accA
type: Gene
locus name: FN0409

SIP1107C85C7813DEC9
type: Function Annotation
comment: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.

SIP2A01F1F71E06A6C1
type: Subunit Annotation
comment: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).

SIP92423756C9DBEFDC
type: Similarity Annotation
comment: Belongs to the AccA family.

PRO_0000223770
type: Chain Annotation
comment: Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
mass: 35303
range: 22861399146969390tt1tt313

22861399146969390tt1
type: Position
type: ExactPosition
position: 1
reference: Q8RG99-1

22861399146969390tt313
type: Position
type: ExactPosition
position: 313
reference: Q8RG99-1

SIPDE4E1794C2654E60
type: Domain Extent Annotation
comment: CoA carboxyltransferase C-terminal
range: 22861399146969390tt34tt288

22861399146969390tt34
type: Position
type: ExactPosition
position: 34
reference: Q8RG99-1

22861399146969390tt288
type: Position
type: ExactPosition
position: 288
reference: Q8RG99-1

Q8RG99-1
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 35303
value: MQFEFQIEELEHKIEELKKFAEEKEVDLSDEIAKLKDQRDIALKVLYDDLTDYQRVMVSRHPERPYTLDYINYITTDFIELHGDRLFRDDPAIVGGLCKIDGKNFMIIGHQKGRTMQEKVFRNFGMANPEGYRKALRLYEMAERFKLPILTFIDTPGAYPGLEAEKHGQGEAIARNLMEMSGIKTPIVSIVIGEGGSGGALGLGVADKVFMLENSVYSVISPEGCAAILYKDPNRVEEAANNLKLSSQSLLKIGLIDGIIDEALGGAHRGPEDTAFNLKNVVLEAVNELEKLPVDELVEKRYEKFRQMGVFNR

http://purl.uniprot.org/uniprot/Q8RG99#attribution-59F6F4DF8DA7A0D31AA2B64E6869E9D5
manual: true
evidence: ECO_0000255
source: MF_00823

http://purl.uniprot.org/uniprot/Q8RG99#attribution-71DD31C3EAE9838607F06234F6539BBA
manual: true
evidence: ECO_0000255
source: PRU01137

Q8RGA0
type: Protein
reviewed: true
created: 2009-12-15
modified: 2023-02-22
version: 97
mnemonic: ACCD_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIP00CD3CD25DEDD34F
enzyme: http://purl.uniprot.org/enzyme/2.1.3.15
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIPEA6357E0C44B50AD
annotation: SIP089E72006DE50B7B
annotation: SIP47F96744FA1F3EFC
annotation: SIP2D3D78D2B1A64CDD
annotation: SIP79C0F53C3830CC17
annotation: SIP680A805B1C197887
annotation: SIP7C7EAC88B6191777
annotation: PRO_0000389745
annotation: SIPCC7A776BFBE173F3
annotation: SIPFF8316A19F11C27C
annotation: SIPA25AAA92238CEACA
annotation: SIP7B1163C824856B7A
annotation: SIPCC899C3E73DCD1C5
annotation: SIP8547F691CED0A194
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/275
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/808
classified with: http://purl.uniprot.org/keywords/863
classified with: GO_0009317
classified with: GO_0003989
classified with: GO_0005524
classified with: GO_0016743
classified with: GO_0008270
classified with: GO_0006633
classified with: GO_2001295
sequence: Q8RGA0-1
proteome: Chromosome

Q8RGA0-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG0777
type: Resource
database: eggNOG
comment: Bacteria

MF_01395
type: Resource
database: HAMAP
comment: AcetylCoA_CT_beta
signature sequence match: HAMAP MF 01395 match 1

IPR034733
type: Resource
database: InterPro
comment: AcCoA_carboxyl

IPR000438
type: Resource
database: InterPro
comment: Acetyl_CoA_COase_Trfase_b_su

IPR011762
type: Resource
database: InterPro
comment: COA_CT_N

PTHR42995
type: Resource
database: PANTHER
comment: ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE SUBUNIT BETA, CHLOROPLASTIC
signature sequence match: PANTHER PTHR42995 match 1

PTHR42995:SF5
type: Resource
database: PANTHER
comment: ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE SUBUNIT BETA, CHLOROPLASTIC
signature sequence match: PANTHER PTHR42995:SF5 match 1

PF01039
type: Resource
database: Pfam
comment: Carboxyl_trans
signature sequence match: Pfam PF01039 match 1

PR01070
type: Resource
database: PRINTS
comment: ACCCTRFRASEB

TIGR00515
type: Resource
database: TIGRFAMs
comment: accD
signature sequence match: TIGRFAMs TIGR00515 match 1

PS50980
type: Resource
database: PROSITE
comment: COA_CT_NTER
signature sequence match: PROSITE PS50980 match 1

SIP00CD3CD25DEDD34F
type: Structured Name
full name: Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
short name: ACCase subunit beta
short name: Acetyl-CoA carboxylase carboxyltransferase subunit beta
ec name: 2.1.3.15

accD
type: Gene
locus name: FN0408

SIPEA6357E0C44B50AD
type: Function Annotation
comment: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.

SIP47F96744FA1F3EFC
type: Cofactor Annotation
comment: Binds 1 zinc ion per subunit.
cofactor: CHEBI_29105

SIP79C0F53C3830CC17
type: Subunit Annotation
comment: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).

SIP7C7EAC88B6191777
type: Similarity Annotation
comment: Belongs to the AccD/PCCB family.

PRO_0000389745
type: Chain Annotation
comment: Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
mass: 33319
range: 22861399147491374tt1tt304

22861399147491374tt1
type: Position
type: ExactPosition
position: 1
reference: Q8RGA0-1

22861399147491374tt304
type: Position
type: ExactPosition
position: 304
reference: Q8RGA0-1

SIPCC7A776BFBE173F3
type: Domain Extent Annotation
comment: CoA carboxyltransferase N-terminal
range: 22861399147491374tt52tt304

22861399147491374tt52
type: Position
type: ExactPosition
position: 52
reference: Q8RGA0-1

SIPFF8316A19F11C27C
type: Zinc Finger Annotation
comment: C4-type
range: 22861399147491374tt56tt78

22861399147491374tt56
type: Position
type: ExactPosition
position: 56
reference: Q8RGA0-1

22861399147491374tt78
type: Position
type: ExactPosition
position: 78
reference: Q8RGA0-1

22861399147491374tt59
type: Position
type: ExactPosition
position: 59
reference: Q8RGA0-1

22861399147491374tt75
type: Position
type: ExactPosition
position: 75
reference: Q8RGA0-1

Q8RGA0-1
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 33319
value: MSILKNLAKNLGLTNITQPKKKYATVGEKKSDEEKERAKYKVKNIDNLKEDEVTKCPSCGVLSHKSEIRANMKMCSNCNHYFNMSARERIELLIDEGTFKEEDVTLTSANPINFPEYVEKIEKAQHDSGMNEGVISGLGEINGLKVSIACMDFNFMGGSMGSVVGEKITAALERAIEHKIPAVVVAISGGARMQEGLTSLMQMAKTSAAVKKMRLAGLPFISVPVNPTTGGVTASFAMLGDIIISEPKARIGFAGPRVIEQTIRQKLPENFQKSEFLQECGMVDVIAKREDLKATIFKVLNDII

http://purl.uniprot.org/uniprot/Q8RGA0#attribution-346A549594E8317A7ADA810973E8C603
manual: true
evidence: ECO_0000255
source: MF_01395

http://purl.uniprot.org/uniprot/Q8RGA0#attribution-A7637AD2023CC0EB7C88908B79959652
manual: true
evidence: ECO_0000255
source: PRU01136

Q8RED7
type: Protein
reviewed: true
created: 2002-11-08
modified: 2023-02-22
version: 107
mnemonic: ACKA_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIPAAE372CE1430EF04
alternative name: SIPD447CFC221064F4E
enzyme: http://purl.uniprot.org/enzyme/2.7.2.1
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIPA3F38AE609ADE980
annotation: SIPC062292A95B6FE49
annotation: SIP8457FE97EFD1BCF3
annotation: SIP97C18D443D8C0748
annotation: SIP96B12C27A7305156
annotation: SIP7BD29EF580551A9D
annotation: SIP627E43B657AE873F
annotation: PRO_0000107561
annotation: SIP055DB7A3F255C884
annotation: SIPDAAD4BECDE406E01
annotation: SIPE89DA179B5F4D69F
annotation: SIP1416133ABB3BB6DA
annotation: SIP822E4C376B16371B
annotation: SIP37FF824EAF97C294
annotation: SIPA378204721782F07
annotation: SIPB4AF1D7E2CF66CFA
annotation: SIPA3B8D4E9337FE8FB
annotation: SIP3E07CC1804B4CC28
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/418
classified with: http://purl.uniprot.org/keywords/460
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005737
classified with: GO_0008776
classified with: GO_0005524
classified with: GO_0000287
classified with: GO_0006083
classified with: GO_0006085
classified with: GO_0016310
sequence: Q8RED7-1
proteome: Chromosome

Q8RED7-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG0282
type: Resource
database: eggNOG
comment: Bacteria

MF_00020
type: Resource
database: HAMAP
comment: Acetate_kinase
signature sequence match: HAMAP MF 00020 match 1

IPR004372
type: Resource
database: InterPro
comment: Ac/propionate_kinase

IPR000890
type: Resource
database: InterPro
comment: Aliphatic_acid_kin_short-chain

IPR023865
type: Resource
database: InterPro
comment: Aliphatic_acid_kinase_CS

IPR043129
type: Resource
database: InterPro
comment: ATPase_NBD

PTHR21060
type: Resource
database: PANTHER
comment: ACETATE KINASE
signature sequence match: PANTHER PTHR21060 match 1

PTHR21060:SF15
type: Resource
database: PANTHER
comment: ACETATE KINASE
signature sequence match: PANTHER PTHR21060:SF15 match 1

PF00871
type: Resource
database: Pfam
comment: Acetate_kinase
signature sequence match: Pfam PF00871 match 1

PIRSF000722
type: Resource
database: PIRSF
comment: Acetate_prop_kin
signature sequence match: PIRSF PIRSF000722 match 1

PR00471
type: Resource
database: PRINTS
comment: ACETATEKNASE

SSF53067
type: Resource
database: SUPFAM
comment: Actin-like ATPase domain
signature sequence match: SUPFAM SSF53067 match 1
signature sequence match: SUPFAM SSF53067 match 2

TIGR00016
type: Resource
database: TIGRFAMs
comment: ackA
signature sequence match: TIGRFAMs TIGR00016 match 1

PS01075
type: Resource
database: PROSITE
comment: ACETATE_KINASE_1
signature sequence match: PROSITE PS01075 match 1

PS01076
type: Resource
database: PROSITE
comment: ACETATE_KINASE_2
signature sequence match: PROSITE PS01076 match 1

SIPAAE372CE1430EF04
type: Structured Name
full name: Acetate kinase
ec name: 2.7.2.1

SIPD447CFC221064F4E
type: Structured Name
full name: Acetokinase

ackA
type: Gene
locus name: FN1171

SIPA3F38AE609ADE980
type: Function Annotation
comment: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.

SIP8457FE97EFD1BCF3
type: Cofactor Annotation
comment: Mg(2+). Can also accept Mn(2+).
cofactor: CHEBI_18420
cofactor: CHEBI_29035

SIP96B12C27A7305156
type: Subunit Annotation
comment: Homodimer.

SIP627E43B657AE873F
type: Similarity Annotation
comment: Belongs to the acetokinase family.

PRO_0000107561
type: Chain Annotation
comment: Acetate kinase
mass: 43625
range: 22861399114135342tt1tt398

22861399114135342tt1
type: Position
type: ExactPosition
position: 1
reference: Q8RED7-1

22861399114135342tt398
type: Position
type: ExactPosition
position: 398
reference: Q8RED7-1

SIP055DB7A3F255C884
type: Active Site Annotation
comment: Proton donor/acceptor
range: 22861399114135342tt149tt149

22861399114135342tt149
type: Position
type: ExactPosition
position: 149
reference: Q8RED7-1

22861399114135342tt7
type: Position
type: ExactPosition
position: 7
reference: Q8RED7-1

22861399114135342tt14
type: Position
type: ExactPosition
position: 14
reference: Q8RED7-1

22861399114135342tt92
type: Position
type: ExactPosition
position: 92
reference: Q8RED7-1

22861399114135342tt208
type: Position
type: ExactPosition
position: 208
reference: Q8RED7-1

22861399114135342tt212
type: Position
type: ExactPosition
position: 212
reference: Q8RED7-1

22861399114135342tt283
type: Position
type: ExactPosition
position: 283
reference: Q8RED7-1

22861399114135342tt285
type: Position
type: ExactPosition
position: 285
reference: Q8RED7-1

22861399114135342tt331
type: Position
type: ExactPosition
position: 331
reference: Q8RED7-1

22861399114135342tt335
type: Position
type: ExactPosition
position: 335
reference: Q8RED7-1

22861399114135342tt385
type: Position
type: ExactPosition
position: 385
reference: Q8RED7-1

SIPA3B8D4E9337FE8FB
type: Site Annotation
comment: Transition state stabilizer
range: 22861399114135342tt181tt181

22861399114135342tt181
type: Position
type: ExactPosition
position: 181
reference: Q8RED7-1

SIP3E07CC1804B4CC28
type: Site Annotation
comment: Transition state stabilizer
range: 22861399114135342tt241tt241

22861399114135342tt241
type: Position
type: ExactPosition
position: 241
reference: Q8RED7-1

substrate

Q8RED7-1
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 43625
value: MKILVINCGSSSLKYQLINPETEEVFAKGLCERIGIDGSKLEYEVVAKDFEKKLETPMPSHKEALELVISHLTDKEIGVIASVDEVDAIGHRVVHGGEEFAQSVLINDAVLKAIEANNDLAPLHNPANLMGIRTCMELMPGKKNVAVFDTAFHQTMKPEAFMYPLPYEDYKELKVRKYGFHGTSHLYVSGIMREIMGNPEHSKIIVCHLGNGASITAVKDGKSVDTSMGLTPLQGLMMGTRCGDIDPAAVLFVKNKRGLTDAQMDDRMNKKSGILGLFGKSSDCRDLENAVVEGDERAILAESVSMHRLRSYIGAYAAIMGGVDAICFTGGIGENSSMTREKALEGLEFLGVELDKEINSVRKKGNVKLSKDSSKVLIYKIPTNEELVIARDTFRLAK

http://purl.uniprot.org/uniprot/Q8RED7#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q8RED7#attribution-C3905A3486D52CE377B6B85D4BC287B0
manual: true
evidence: ECO_0000255
source: MF_00020

Q8RDZ7
type: Protein
reviewed: true
created: 2002-08-02
modified: 2023-05-03
version: 114
mnemonic: ACPS_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIP2BEBC682D9C5D011
alternative name: SIP479C3A2215184A35
enzyme: http://purl.uniprot.org/enzyme/2.7.8.7
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIP261B51E81A5D8F38
annotation: SIP5FE5F1D317701B0F
annotation: SIP946B0064608268DD
annotation: SIP1D678F41DCBAD4A4
annotation: SIPC59AF7F59173DBC0
annotation: PRO_0000175649
annotation: SIP5E8F1169CCA9C166
annotation: SIPB5C040669AEC59AE
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/275
classified with: http://purl.uniprot.org/keywords/460
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/808
classified with: GO_0005737
classified with: GO_0008897
classified with: GO_0000287
classified with: GO_0006633
sequence: MIIGIGNDIIEIERIEKAISKEGFKNKIYTQKELENIQKRGNRTETYAGIFSAKEAISKAIGTGVREFSLTDLEILNDDLGKPYVVVSEKLDKILRNKKENYQIEISISHSRKYATAMAIIL
proteome: Chromosome

Q8RDZ7-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG0736
type: Resource
database: eggNOG
comment: Bacteria

http://purl.uniprot.org/gene3d/3.90.470.20
type: Resource
database: Gene3D
comment: 4'-phosphopantetheinyl transferase domain
signature sequence match: Gene3D 3.90.470.20 match 1

MF_00101
type: Resource
database: HAMAP
comment: AcpS
signature sequence match: HAMAP MF 00101 match 1

IPR008278
type: Resource
database: InterPro
comment: 4-PPantetheinyl_Trfase_dom

IPR037143
type: Resource
database: InterPro
comment: 4-PPantetheinyl_Trfase_dom_sf

IPR002582
type: Resource
database: InterPro
comment: ACPS

IPR004568
type: Resource
database: InterPro
comment: Ppantetheine-prot_Trfase_dom

PF01648
type: Resource
database: Pfam
comment: ACPS
signature sequence match: Pfam PF01648 match 1

SSF56214
type: Resource
database: SUPFAM
comment: 4'-phosphopantetheinyl transferase
signature sequence match: SUPFAM SSF56214 match 1

TIGR00516
type: Resource
database: TIGRFAMs
comment: acpS
signature sequence match: TIGRFAMs TIGR00516 match 1

TIGR00556
type: Resource
database: TIGRFAMs
comment: pantethn_trn
signature sequence match: TIGRFAMs TIGR00556 match 1

SIP2BEBC682D9C5D011
type: Structured Name
full name: Holo-[acyl-carrier-protein] synthase
short name: Holo-ACP synthase
ec name: 2.7.8.7

SIP479C3A2215184A35
type: Structured Name
full name: 4'-phosphopantetheinyl transferase AcpS

acpS
type: Gene
locus name: FN1342

SIP261B51E81A5D8F38
type: Function Annotation
comment: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

SIPC59AF7F59173DBC0
type: Similarity Annotation
comment: Belongs to the P-Pant transferase superfamily. AcpS family.

PRO_0000175649
type: Chain Annotation
comment: Holo-[acyl-carrier-protein] synthase
mass: 13834
range: 22861399098799918tt1tt122

22861399098799918tt1
type: Position
type: ExactPosition
position: 1
reference: MIIGIGNDIIEIERIEKAISKEGFKNKIYTQKELENIQKRGNRTETYAGIFSAKEAISKAIGTGVREFSLTDLEILNDDLGKPYVVVSEKLDKILRNKKENYQIEISISHSRKYATAMAIIL

22861399098799918tt122
type: Position
type: ExactPosition
position: 122
reference: MIIGIGNDIIEIERIEKAISKEGFKNKIYTQKELENIQKRGNRTETYAGIFSAKEAISKAIGTGVREFSLTDLEILNDDLGKPYVVVSEKLDKILRNKKENYQIEISISHSRKYATAMAIIL

22861399098799918tt8
type: Position
type: ExactPosition
position: 8
reference: MIIGIGNDIIEIERIEKAISKEGFKNKIYTQKELENIQKRGNRTETYAGIFSAKEAISKAIGTGVREFSLTDLEILNDDLGKPYVVVSEKLDKILRNKKENYQIEISISHSRKYATAMAIIL

22861399098799918tt55
type: Position
type: ExactPosition
position: 55
reference: MIIGIGNDIIEIERIEKAISKEGFKNKIYTQKELENIQKRGNRTETYAGIFSAKEAISKAIGTGVREFSLTDLEILNDDLGKPYVVVSEKLDKILRNKKENYQIEISISHSRKYATAMAIIL

MIIGIGNDIIEIERIEKAISKEGFKNKIYTQKELENIQKRGNRTETYAGIFSAKEAISKAIGTGVREFSLTDLEILNDDLGKPYVVVSEKLDKILRNKKENYQIEISISHSRKYATAMAIIL
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 13834

http://purl.uniprot.org/uniprot/Q8RDZ7#attribution-1F5F5386E209DFCC3422387253639116
manual: true
evidence: ECO_0000255
source: MF_00101

Q8RGX5
type: Protein
reviewed: true
created: 2002-08-02
modified: 2023-02-22
version: 113
mnemonic: ACP_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIPF018D8BE7E205B4F
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIPC702496A46B30647
annotation: SIP7BA2275EF8E42A60
annotation: SIPF79DAA774A950E60
annotation: SIP1E3DB6AD2BE122C5
annotation: SIP84DDFCDA645A16AD
annotation: PRO_0000180139
annotation: SIP940B7AF2265111D1
annotation: SIPABCFBA766B2A25D9
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/275
classified with: http://purl.uniprot.org/keywords/596
classified with: http://purl.uniprot.org/keywords/597
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005829
classified with: GO_0000035
classified with: GO_0000036
classified with: GO_0031177
classified with: GO_0009245
sequence: MLDKVKEIIVEQLGVDADQIKPESNFVDDLGADSLDTVELIMSFEEEFGVEIPDTEAEKIKTVQDVINYIEANKK
proteome: Chromosome

Q8RGX5-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG0236
type: Resource
database: eggNOG
comment: Bacteria

http://purl.uniprot.org/gene3d/1.10.1200.10
type: Resource
database: Gene3D
comment: ACP-like
signature sequence match: Gene3D 1.10.1200.10 match 1

MF_01217
type: Resource
database: HAMAP
comment: Acyl_carrier
signature sequence match: HAMAP MF 01217 match 1

IPR036736
type: Resource
database: InterPro
comment: ACP-like_sf

IPR003231
type: Resource
database: InterPro
comment: Acyl_carrier

IPR020806
type: Resource
database: InterPro
comment: PKS_PP-bd

IPR009081
type: Resource
database: InterPro
comment: PP-bd_ACP

IPR006162
type: Resource
database: InterPro
comment: Ppantetheine_attach_site

PTHR20863
type: Resource
database: PANTHER
comment: ACYL CARRIER PROTEIN
signature sequence match: PANTHER PTHR20863 match 1

PTHR20863:SF28
type: Resource
database: PANTHER
comment: ACYL CARRIER PROTEIN, MITOCHONDRIAL
signature sequence match: PANTHER PTHR20863:SF28 match 1

PF00550
type: Resource
database: Pfam
comment: PP-binding
signature sequence match: Pfam PF00550 match 1

SM00823
type: Resource
database: SMART
comment: PKS_PP
signature sequence match: SMART SM00823 match 1

SSF47336
type: Resource
database: SUPFAM
comment: ACP-like
signature sequence match: SUPFAM SSF47336 match 1

TIGR00517
type: Resource
database: TIGRFAMs
comment: acyl_carrier
signature sequence match: TIGRFAMs TIGR00517 match 1

PS50075
type: Resource
database: PROSITE
comment: CARRIER
signature sequence match: PROSITE PS50075 match 1

PS00012
type: Resource
database: PROSITE
comment: PHOSPHOPANTETHEINE
signature sequence match: PROSITE PS00012 match 1

SIPF018D8BE7E205B4F
type: Structured Name
full name: Acyl carrier protein
short name: ACP

acpP
type: Gene
locus name: FN0150

SIPC702496A46B30647
type: Function Annotation
comment: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

SIP1E3DB6AD2BE122C5
type: PTM Annotation
comment: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.

SIP84DDFCDA645A16AD
type: Similarity Annotation
comment: Belongs to the acyl carrier protein (ACP) family.

PRO_0000180139
type: Chain Annotation
comment: Acyl carrier protein
mass: 8443
range: 22861399148999982tt1tt75

22861399148999982tt1
type: Position
type: ExactPosition
position: 1
reference: MLDKVKEIIVEQLGVDADQIKPESNFVDDLGADSLDTVELIMSFEEEFGVEIPDTEAEKIKTVQDVINYIEANKK

22861399148999982tt75
type: Position
type: ExactPosition
position: 75
reference: MLDKVKEIIVEQLGVDADQIKPESNFVDDLGADSLDTVELIMSFEEEFGVEIPDTEAEKIKTVQDVINYIEANKK

SIP940B7AF2265111D1
type: Domain Extent Annotation
comment: Carrier
range: 22861399148999982tt1tt74

22861399148999982tt74
type: Position
type: ExactPosition
position: 74
reference: MLDKVKEIIVEQLGVDADQIKPESNFVDDLGADSLDTVELIMSFEEEFGVEIPDTEAEKIKTVQDVINYIEANKK

SIPABCFBA766B2A25D9
type: Modified Residue Annotation
comment: O-(pantetheine 4'-phosphoryl)serine
range: 22861399148999982tt34tt34

22861399148999982tt34
type: Position
type: ExactPosition
position: 34
reference: MLDKVKEIIVEQLGVDADQIKPESNFVDDLGADSLDTVELIMSFEEEFGVEIPDTEAEKIKTVQDVINYIEANKK

MLDKVKEIIVEQLGVDADQIKPESNFVDDLGADSLDTVELIMSFEEEFGVEIPDTEAEKIKTVQDVINYIEANKK
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 8443

http://purl.uniprot.org/uniprot/Q8RGX5#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q8RGX5#attribution-EBFCF1D44A6B78477DFBD33475E43FB0
manual: true
evidence: ECO_0000255
source: MF_01217

http://purl.uniprot.org/uniprot/Q8RGX5#attribution-D13C97E04C041CF3567C01508AE538D1
manual: true
evidence: ECO_0000255
source: PRU00258

Q8RGH3
type: Protein
reviewed: true
created: 2003-11-21
modified: 2023-02-22
version: 102
mnemonic: ALF1_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIPB8F855C89E922D91
alternative name: SIP551F08F931F80FCC
enzyme: http://purl.uniprot.org/enzyme/4.1.2.13
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIP0A6FD8179A32A5F5
annotation: SIP926D37AE4BD64E28
annotation: SIPE0A314AEFEBD4B99
annotation: PRO_0000216900
annotation: SIP272A99709F8FFE42
annotation: SIPF65EA147521B529F
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/324
classified with: http://purl.uniprot.org/keywords/456
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/704
classified with: GO_0004332
classified with: GO_0006096
sequence: Q8RGH3-1
proteome: Chromosome

Q8RGH3-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG3588
type: Resource
database: eggNOG
comment: Bacteria

http://purl.uniprot.org/gene3d/3.20.20.70
type: Resource
database: Gene3D
comment: Aldolase class I
signature sequence match: Gene3D 3.20.20.70 match 1

MF_00729
type: Resource
database: HAMAP
comment: FBP_aldolase_1
signature sequence match: HAMAP MF 00729 match 1

IPR013785
type: Resource
database: InterPro
comment: Aldolase_TIM

IPR000741
type: Resource
database: InterPro
comment: FBA_I

IPR023014
type: Resource
database: InterPro
comment: FBA_I_Gram+-type

PTHR11627
type: Resource
database: PANTHER
comment: FRUCTOSE-BISPHOSPHATE ALDOLASE
signature sequence match: PANTHER PTHR11627 match 1

PTHR11627:SF80
type: Resource
database: PANTHER
comment: FRUCTOSE-BISPHOSPHATE ALDOLASE
signature sequence match: PANTHER PTHR11627:SF80 match 1

PF00274
type: Resource
database: Pfam
comment: Glycolytic
signature sequence match: Pfam PF00274 match 1

SSF51569
type: Resource
database: SUPFAM
comment: Aldolase
signature sequence match: SUPFAM SSF51569 match 1

SIPB8F855C89E922D91
type: Structured Name
full name: Fructose-bisphosphate aldolase class 1
ec name: 4.1.2.13

SIP551F08F931F80FCC
type: Structured Name
full name: Fructose-bisphosphate aldolase class I
short name: FBP aldolase

fda
type: Gene
locus name: FN0322

SIPE0A314AEFEBD4B99
type: Similarity Annotation
comment: Belongs to the class I fructose-bisphosphate aldolase family.

PRO_0000216900
type: Chain Annotation
comment: Fructose-bisphosphate aldolase class 1
mass: 32896
range: 22861399147950894tt1tt295

22861399147950894tt1
type: Position
type: ExactPosition
position: 1
reference: Q8RGH3-1

22861399147950894tt295
type: Position
type: ExactPosition
position: 295
reference: Q8RGH3-1

SIP272A99709F8FFE42
type: Active Site Annotation
comment: Proton acceptor
range: 22861399147950894tt176tt176

22861399147950894tt176
type: Position
type: ExactPosition
position: 176
reference: Q8RGH3-1

SIPF65EA147521B529F
type: Active Site Annotation
comment: Schiff-base intermediate with dihydroxyacetone-P
range: 22861399147950894tt213tt213

22861399147950894tt213
type: Position
type: ExactPosition
position: 213
reference: Q8RGH3-1

Q8RGH3-1
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 32896
value: MNEKLEKMRNGKGFIAALDQSGGSTPKALKLYGVNENEYSNDKEMFDLIHKMRTRIIKSPAFNESKILGAILFEQTMDSKIDGKYTADFLWEEKKVLPFLKIDKGLNDLDADGVQTMKPNPTLADLLKRANERHIFGTKMRSVIKKASPAGIARVVEQQFEVAAQVVAAGLIPIIEPEVDINNVDKVQCEEILRDEIRKHLNALPETSNVMLKLTLPTVENLYEEFTKHPRVVRVVALSGGYSREKANDILSKNKGVIASFSRALTEGLSAQQTDEEFNKTLAASIDGIYEASVK

http://purl.uniprot.org/uniprot/Q8RGH3#attribution-9DFCDCB6D9999A00F0FD1B3CD48D09D6
manual: true
evidence: ECO_0000255
source: MF_00729

Q8RGA2
type: Protein
reviewed: true
created: 2002-10-10
modified: 2023-02-22
version: 119
mnemonic: ALR_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIPA9A4E98D933D1F32
enzyme: http://purl.uniprot.org/enzyme/5.1.1.1
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIPE49BAA968B68BC6E
annotation: SIP45F19846BB099160
annotation: SIPA5434BE7755083B4
annotation: SIPFCD95CE3C1FF4A9D
annotation: SIP896003FE6EDF85E5
annotation: PRO_0000114520
annotation: SIP9C7ABE1B74AE93CF
annotation: SIPA14125656D78BAA7
annotation: SIPA59132463BC7888B
annotation: SIP2A57E17FB42104CD
annotation: SIP35DF47A6C7E7248F
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/413
classified with: http://purl.uniprot.org/keywords/663
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005829
classified with: GO_0008784
classified with: GO_0030170
classified with: GO_0030632
sequence: Q8RGA2-1
proteome: Chromosome

Q8RGA2-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG0787
type: Resource
database: eggNOG
comment: Bacteria

cd00430
type: Resource
database: CDD
comment: PLPDE_III_AR
signature sequence match: CDD cd00430 match 1

http://purl.uniprot.org/gene3d/3.20.20.10
type: Resource
database: Gene3D
comment: Alanine racemase
signature sequence match: Gene3D 3.20.20.10 match 1

MF_01201
type: Resource
database: HAMAP
comment: Ala_racemase
signature sequence match: HAMAP MF 01201 match 1

IPR000821
type: Resource
database: InterPro
comment: Ala_racemase

IPR009006
type: Resource
database: InterPro
comment: Ala_racemase/Decarboxylase_C

IPR011079
type: Resource
database: InterPro
comment: Ala_racemase_C

IPR001608
type: Resource
database: InterPro
comment: Ala_racemase_N

IPR020622
type: Resource
database: InterPro
comment: Ala_racemase_pyridoxalP-BS

IPR029066
type: Resource
database: InterPro
comment: PLP-binding_barrel

PTHR30511
type: Resource
database: PANTHER
comment: ALANINE RACEMASE
signature sequence match: PANTHER PTHR30511 match 1

PTHR30511:SF0
type: Resource
database: PANTHER
comment: ALANINE RACEMASE, CATABOLIC-RELATED
signature sequence match: PANTHER PTHR30511:SF0 match 1

PF00842
type: Resource
database: Pfam
comment: Ala_racemase_C
signature sequence match: Pfam PF00842 match 1

PF01168
type: Resource
database: Pfam
comment: Ala_racemase_N
signature sequence match: Pfam PF01168 match 1

PR00992
type: Resource
database: PRINTS
comment: ALARACEMASE

SM01005
type: Resource
database: SMART
comment: Ala_racemase_C
signature sequence match: SMART SM01005 match 1

SSF50621
type: Resource
database: SUPFAM
comment: Alanine racemase C-terminal domain-like
signature sequence match: SUPFAM SSF50621 match 1

SSF51419
type: Resource
database: SUPFAM
comment: PLP-binding barrel
signature sequence match: SUPFAM SSF51419 match 1

TIGR00492
type: Resource
database: TIGRFAMs
comment: alr
signature sequence match: TIGRFAMs TIGR00492 match 1

PS00395
type: Resource
database: PROSITE
comment: ALANINE_RACEMASE
signature sequence match: PROSITE PS00395 match 1

SIPA9A4E98D933D1F32
type: Structured Name
full name: Alanine racemase
ec name: 5.1.1.1

alr
type: Gene
locus name: FN0406

SIPE49BAA968B68BC6E
type: Function Annotation
comment: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

SIP896003FE6EDF85E5
type: Similarity Annotation
comment: Belongs to the alanine racemase family.

PRO_0000114520
type: Chain Annotation
comment: Alanine racemase
mass: 39835
range: 22861399147491886tt1tt354

22861399147491886tt1
type: Position
type: ExactPosition
position: 1
reference: Q8RGA2-1

22861399147491886tt354
type: Position
type: ExactPosition
position: 354
reference: Q8RGA2-1

SIP9C7ABE1B74AE93CF
type: Active Site Annotation
comment: Proton acceptor; specific for D-alanine
range: 22861399147491886tt33tt33

22861399147491886tt33
type: Position
type: ExactPosition
position: 33
reference: Q8RGA2-1

SIPA14125656D78BAA7
type: Active Site Annotation
comment: Proton acceptor; specific for L-alanine
range: 22861399147491886tt251tt251

22861399147491886tt251
type: Position
type: ExactPosition
position: 251
reference: Q8RGA2-1

22861399147491886tt127
type: Position
type: ExactPosition
position: 127
reference: Q8RGA2-1

22861399147491886tt299
type: Position
type: ExactPosition
position: 299
reference: Q8RGA2-1

SIP35DF47A6C7E7248F
type: Modified Residue Annotation
comment: N6-(pyridoxal phosphate)lysine
range: 22861399147491886tt33tt33

substrate

Q8RGA2-1
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 39835
value: MRTWIEIDKENLKYNVLKLKEIANNKEILGVVKANAYGLGSIEIAKILKEVEVKLFGVANLEEAIELQEAGIKDKILILGASFEDELVEATKRGVHVAISSMGQLQFLVSKNLNPNIHLKFDTGMTRLGFEVDDAEKVIEYCKNNNLNLVGIFSHLSDSDGNTIETKNFTLEQIEKFKKIVNSLNLEYIHISNSAGITNFHNDILGNLVRLGIGMYSFTGNKKTPYLKNIFTIKSKILFIKKVKKDSFVSYGRHYTLPADSTYAVLPIGYADGLKKYLSKGGYVLINNHRCEIIGNICMDMTMIRVPKEIENSIKIGDEVTVINADILDNLNIPELCVWEFMTGIGRRVKRIIV

http://purl.uniprot.org/uniprot/Q8RGA2#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q8RGA2#attribution-35F80A75CD326B6A74A2E2D4A39D726C
manual: true
evidence: ECO_0000255
source: MF_01201

Q8RHT8
type: Protein
reviewed: true
created: 2002-11-08
modified: 2023-05-03
version: 117
mnemonic: AMPA_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIP4C2E197687D5A48E
alternative name: SIP8E066A1821A9A88A
alternative name: SIP2BA06BA51D2DD54D
enzyme: http://purl.uniprot.org/enzyme/3.4.11.1
enzyme: http://purl.uniprot.org/enzyme/3.4.11.10
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIP3D59045AB65203B1
annotation: SIP7BDDC186C264ACD8
annotation: SIP2AF5BD645163B257
annotation: SIPDF6C88AC276CEFC7
annotation: SIP0E3E425FCB605FE4
annotation: SIP0CF9784FABC659D1
annotation: PRO_0000165754
annotation: SIP2465D1BCE1AED864
annotation: SIPFC1A5621C9F4BFD3
annotation: SIP325C2AD1E5F6E0A1
annotation: SIP601A6ABA0C8C1851
annotation: SIPBB6D65542E76B402
annotation: SIP1EE248B917255CE7
annotation: SIPAEA03885AAE5691D
annotation: SIP08954F651895CE63
annotation: SIP77759013B991740C
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/31
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/464
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005737
classified with: GO_0030145
classified with: GO_0070006
classified with: GO_0008233
classified with: GO_0006508
sequence: Q8RHT8-1
proteome: Chromosome

Q8RHT8-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG0260
type: Resource
database: eggNOG
comment: Bacteria

cd00433
type: Resource
database: CDD
comment: Peptidase_M17
signature sequence match: CDD cd00433 match 1

http://purl.uniprot.org/gene3d/3.40.220.10
type: Resource
database: Gene3D
comment: Leucine Aminopeptidase, subunit E, domain 1
signature sequence match: Gene3D 3.40.220.10 match 1

http://purl.uniprot.org/gene3d/3.40.630.10
type: Resource
database: Gene3D
comment: Zn peptidases
signature sequence match: Gene3D 3.40.630.10 match 1

MF_00181
type: Resource
database: HAMAP
comment: Cytosol_peptidase_M17
signature sequence match: HAMAP MF 00181 match 1

IPR011356
type: Resource
database: InterPro
comment: Leucine_aapep/pepB

IPR043472
type: Resource
database: InterPro
comment: Macro_dom-like

IPR000819
type: Resource
database: InterPro
comment: Peptidase_M17_C

IPR023042
type: Resource
database: InterPro
comment: Peptidase_M17_leu_NH2_pept

IPR008283
type: Resource
database: InterPro
comment: Peptidase_M17_N

PTHR11963:SF23
type: Resource
database: PANTHER
comment: CYTOSOL AMINOPEPTIDASE
signature sequence match: PANTHER PTHR11963:SF23 match 1

PTHR11963
type: Resource
database: PANTHER
comment: LEUCINE AMINOPEPTIDASE-RELATED
signature sequence match: PANTHER PTHR11963 match 1

PF00883
type: Resource
database: Pfam
comment: Peptidase_M17
signature sequence match: Pfam PF00883 match 1

PF02789
type: Resource
database: Pfam
comment: Peptidase_M17_N
signature sequence match: Pfam PF02789 match 1

PR00481
type: Resource
database: PRINTS
comment: LAMNOPPTDASE

SSF52949
type: Resource
database: SUPFAM
comment: Macro domain-like
signature sequence match: SUPFAM SSF52949 match 1

SSF53187
type: Resource
database: SUPFAM
comment: Zn-dependent exopeptidases
signature sequence match: SUPFAM SSF53187 match 1

PS00631
type: Resource
database: PROSITE
comment: CYTOSOL_AP
signature sequence match: PROSITE PS00631 match 1

SIP4C2E197687D5A48E
type: Structured Name
full name: Probable cytosol aminopeptidase
ec name: 3.4.11.1

SIP8E066A1821A9A88A
type: Structured Name
full name: Leucine aminopeptidase
short name: LAP
ec name: 3.4.11.10

SIP2BA06BA51D2DD54D
type: Structured Name
full name: Leucyl aminopeptidase

pepA
type: Gene
locus name: FN1906

SIP3D59045AB65203B1
type: Function Annotation
comment: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

SIPDF6C88AC276CEFC7
type: Cofactor Annotation
comment: Binds 2 manganese ions per subunit.
cofactor: CHEBI_29035

SIP0CF9784FABC659D1
type: Similarity Annotation
comment: Belongs to the peptidase M17 family.

PRO_0000165754
type: Chain Annotation
comment: Probable cytosol aminopeptidase
mass: 53585
range: 22861399165515822tt1tt478

22861399165515822tt1
type: Position
type: ExactPosition
position: 1
reference: Q8RHT8-1

22861399165515822tt478
type: Position
type: ExactPosition
position: 478
reference: Q8RHT8-1

22861399165515822tt256
type: Position
type: ExactPosition
position: 256
reference: Q8RHT8-1

22861399165515822tt330
type: Position
type: ExactPosition
position: 330
reference: Q8RHT8-1

22861399165515822tt244
type: Position
type: ExactPosition
position: 244
reference: Q8RHT8-1

22861399165515822tt249
type: Position
type: ExactPosition
position: 249
reference: Q8RHT8-1

22861399165515822tt267
type: Position
type: ExactPosition
position: 267
reference: Q8RHT8-1

22861399165515822tt326
type: Position
type: ExactPosition
position: 326
reference: Q8RHT8-1

22861399165515822tt328
type: Position
type: ExactPosition
position: 328
reference: Q8RHT8-1

2
subclass of: CHEBI_29035

1
subclass of: CHEBI_29035

Q8RHT8-1
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 53585
value: MSFQCVKKYEDSYDKYVLAATSEKVVLPDYLDKESKKIAETIIKKNKFTAKASEKISMTLVNKKKVIEFIIIGLGEKKKLDAKNTRQYLFDGLKNIIGKVLFSFDNKDLDNIDILAEVVEHINYKFDKYFSKKKEEFLEVSYLTDKKVPKLIEGYELAKISNIVKDLVNEQAEVLNPKELADRATKLGKKFGFDVEILDEKKAQKLGMNAYLSVARAAHHRPYVIVMRYKGNAKSKYTFGLVGKGLTYDTGGLSLKPTDSMLTMRCDMGGAATMIGAMCSVAKMKLKKNVTCVVAACENSIGPNAYRPGDILTAMNGKTIEVTNTDAEGRLTLADALTYIVRKEKVNEVIDAATLTGAIMVALGEDVTGVFTNDEKMARKVIDASENWNEYFWQMPMFDLYKKNLKSSYADMQNTGVRWGGSTNAAKFLEEFIDDTKWVHLDIAGTAWASGANPYYSQKGATGQVFRTVYSYIKDNKN

http://purl.uniprot.org/uniprot/Q8RHT8#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q8RHT8#attribution-5B745BD8E303FB1FA1AC6F6C6041F55D
manual: true
evidence: ECO_0000255
source: MF_00181

Q8RDM9
type: Protein
reviewed: true
created: 2002-08-30
modified: 2023-05-03
version: 107
mnemonic: APT_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIPC62527ADDBF300CB
enzyme: http://purl.uniprot.org/enzyme/2.4.2.7
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIPC587CA00EFCAB164
annotation: SIPF08588C68D3724B8
annotation: SIPC2C5142FE5DA9B9E
annotation: SIPA57F3CF96A5366F9
annotation: SIP2EFDC6AEF2FD5384
annotation: SIP3E789F70BD9FBD6A
annotation: PRO_0000149385
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/328
classified with: http://purl.uniprot.org/keywords/660
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005737
classified with: GO_0002055
classified with: GO_0003999
classified with: GO_0016208
classified with: GO_0006168
classified with: GO_0044209
classified with: GO_0006166
sequence: MDLKNYVASIENYPKEGIIFRDITPLMNDGEAYKYATEKIVEFAKDHHIDIVVGPEARGFIFGCPVSYALGVGFVPVRKPGKLPREVIEYAYDLEYGSNKLCLHKDSIKPGQKVLVVDDLLATGGTVEATIKLVEELGGVVAGLAFLIELVDLKGRERLDKYPMITLMQY
proteome: Chromosome

Q8RDM9-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG0503
type: Resource
database: eggNOG
comment: Bacteria

cd06223
type: Resource
database: CDD
comment: PRTases_typeI
signature sequence match: CDD cd06223 match 1

MF_00004
type: Resource
database: HAMAP
comment: Aden_phosphoribosyltr
signature sequence match: HAMAP MF 00004 match 1

IPR005764
type: Resource
database: InterPro
comment: Ade_phspho_trans

IPR000836
type: Resource
database: InterPro
comment: PRibTrfase_dom

IPR029057
type: Resource
database: InterPro
comment: PRTase-like

PTHR32315
type: Resource
database: PANTHER
comment: ADENINE PHOSPHORIBOSYLTRANSFERASE
signature sequence match: PANTHER PTHR32315 match 1

PTHR32315:SF3
type: Resource
database: PANTHER
comment: ADENINE PHOSPHORIBOSYLTRANSFERASE
signature sequence match: PANTHER PTHR32315:SF3 match 1

PF00156
type: Resource
database: Pfam
comment: Pribosyltran
signature sequence match: Pfam PF00156 match 1

SSF53271
type: Resource
database: SUPFAM
comment: PRTase-like
signature sequence match: SUPFAM SSF53271 match 1

TIGR01090
type: Resource
database: TIGRFAMs
comment: apt
signature sequence match: TIGRFAMs TIGR01090 match 1

PS00103
type: Resource
database: PROSITE
comment: PUR_PYR_PR_TRANSFER
signature sequence match: PROSITE PS00103 match 1

SIPC62527ADDBF300CB
type: Structured Name
full name: Adenine phosphoribosyltransferase
short name: APRT
ec name: 2.4.2.7

apt
type: Gene
locus name: FN1483

SIPC587CA00EFCAB164
type: Function Annotation
comment: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.

SIPA57F3CF96A5366F9
type: Subunit Annotation
comment: Homodimer.

SIP3E789F70BD9FBD6A
type: Similarity Annotation
comment: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

PRO_0000149385
type: Chain Annotation
comment: Adenine phosphoribosyltransferase
mass: 18910
range: 22861399097948462tt1tt170

22861399097948462tt1
type: Position
type: ExactPosition
position: 1
reference: MDLKNYVASIENYPKEGIIFRDITPLMNDGEAYKYATEKIVEFAKDHHIDIVVGPEARGFIFGCPVSYALGVGFVPVRKPGKLPREVIEYAYDLEYGSNKLCLHKDSIKPGQKVLVVDDLLATGGTVEATIKLVEELGGVVAGLAFLIELVDLKGRERLDKYPMITLMQY

22861399097948462tt170
type: Position
type: ExactPosition
position: 170
reference: MDLKNYVASIENYPKEGIIFRDITPLMNDGEAYKYATEKIVEFAKDHHIDIVVGPEARGFIFGCPVSYALGVGFVPVRKPGKLPREVIEYAYDLEYGSNKLCLHKDSIKPGQKVLVVDDLLATGGTVEATIKLVEELGGVVAGLAFLIELVDLKGRERLDKYPMITLMQY

MDLKNYVASIENYPKEGIIFRDITPLMNDGEAYKYATEKIVEFAKDHHIDIVVGPEARGFIFGCPVSYALGVGFVPVRKPGKLPREVIEYAYDLEYGSNKLCLHKDSIKPGQKVLVVDDLLATGGTVEATIKLVEELGGVVAGLAFLIELVDLKGRERLDKYPMITLMQY
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 18910

http://purl.uniprot.org/uniprot/Q8RDM9#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q8RDM9#attribution-0F27B14A644DA8A39AD9BF322F5FDB4F
manual: true
evidence: ECO_0000255
source: MF_00004

Q8RF47
type: Protein
reviewed: true
created: 2003-12-15
modified: 2023-02-22
version: 116
mnemonic: AROB_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIP8E62B12BCA5BD2F4
domain: SIPA01D68DA8F1CD783
domain: SIP120253D824C50AD9
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIPD83CD8860156798F
annotation: SIP2AAF5C9D2E5BDF20
annotation: SIP14C0BB58E84C963E
annotation: SIP4E8249EFA70CB20B
annotation: SIPC6778E8CA5548CBE
annotation: SIP36E2D8EA49CBFD66
annotation: SIP5ADAA9671B623B8F
annotation: SIPA3EDFE5981930D17
annotation: PRO_0000140814
annotation: SIP01B0D670B39BC7A0
annotation: SIPC75A57C338120475
annotation: SIPFD7BF49E3402F89C
annotation: SIPEA08AD2046543209
annotation: SIPBC4267313902F56A
annotation: SIP0A2CF1AD48AE016B
annotation: SIP9C72FDAEFD5D69D3
annotation: SIPFD9C992B21D9823E
annotation: SIP5E5E5119CFB714D3
annotation: SIPC0586CBAFB29E833
annotation: SIPAA27321AD4AED127
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/57
classified with: http://purl.uniprot.org/keywords/170
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/378
classified with: http://purl.uniprot.org/keywords/456
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/511
classified with: http://purl.uniprot.org/keywords/520
classified with: http://purl.uniprot.org/keywords/547
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/862
classified with: GO_0005737
classified with: GO_0003856
classified with: GO_0016787
classified with: GO_0046872
classified with: GO_0000166
classified with: GO_0008652
classified with: GO_0009073
classified with: GO_0009423
sequence: Q8RF47-1
proteome: Chromosome

Q8RF47-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG0248
type: Resource
database: eggNOG
comment: Bacteria

COG0337
type: Resource
database: eggNOG
comment: Bacteria

cd08195
type: Resource
database: CDD
comment: DHQS
signature sequence match: CDD cd08195 match 1

http://purl.uniprot.org/gene3d/1.20.1090.10
type: Resource
database: Gene3D
comment: Dehydroquinate synthase-like - alpha domain
signature sequence match: Gene3D 1.20.1090.10 match 1

http://purl.uniprot.org/gene3d/3.30.420.150
type: Resource
database: Gene3D
comment: Exopolyphosphatase. Domain 2
signature sequence match: Gene3D 3.30.420.150 match 1

MF_00110
type: Resource
database: HAMAP
comment: DHQ_synthase
signature sequence match: HAMAP MF 00110 match 1

IPR016037
type: Resource
database: InterPro
comment: DHQ_synth_AroB

IPR030960
type: Resource
database: InterPro
comment: DHQS/DOIS

IPR003695
type: Resource
database: InterPro
comment: Ppx_GppA

PTHR43622
type: Resource
database: PANTHER
comment: 3-DEHYDROQUINATE SYNTHASE
signature sequence match: PANTHER PTHR43622 match 1

PTHR43622:SF7
type: Resource
database: PANTHER
comment: 3-DEHYDROQUINATE SYNTHASE, CHLOROPLASTIC
signature sequence match: PANTHER PTHR43622:SF7 match 1

PF01761
type: Resource
database: Pfam
comment: DHQ_synthase
signature sequence match: Pfam PF01761 match 1

PF02541
type: Resource
database: Pfam
comment: Ppx-GppA
signature sequence match: Pfam PF02541 match 1

SSF56796
type: Resource
database: SUPFAM
comment: Dehydroquinate synthase-like
signature sequence match: SUPFAM SSF56796 match 1

TIGR01357
type: Resource
database: TIGRFAMs
comment: aroB
signature sequence match: TIGRFAMs TIGR01357 match 1

SIP8E62B12BCA5BD2F4
type: Structured Name
full name: Bifunctional 3-dehydroquinate synthase/phosphatase

SIP73C605B0B8CF744F
type: Structured Name
full name: 3-dehydroquinate synthase
ec name: 4.2.3.4

SIP037279F0CC9DB6AB
type: Structured Name
full name: Unknown phosphatase
ec name: 3.6.1.-

aroB
type: Gene
locus name: FN0871

SIP14C0BB58E84C963E
type: Cofactor Annotation
comment: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
cofactor: CHEBI_48828
cofactor: CHEBI_29105

SIPC6778E8CA5548CBE
type: Subunit Annotation
comment: Monomer.

SIP5ADAA9671B623B8F
type: Similarity Annotation
comment: In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.

SIPA3EDFE5981930D17
type: Similarity Annotation
comment: In the C-terminal section; belongs to the GppA/Ppx family.

PRO_0000140814
type: Chain Annotation
comment: Bifunctional 3-dehydroquinate synthase/phosphatase
mass: 76592
range: 22861399129863982tt1tt664

22861399129863982tt1
type: Position
type: ExactPosition
position: 1
reference: Q8RF47-1

22861399129863982tt664
type: Position
type: ExactPosition
position: 664
reference: Q8RF47-1

SIP01B0D670B39BC7A0
type: Region Annotation
comment: 3-dehydroquinate synthase
range: 22861399129863982tt1tt352

22861399129863982tt352
type: Position
type: ExactPosition
position: 352
reference: Q8RF47-1

SIPC75A57C338120475
type: Region Annotation
comment: GPPA/PPX
range: 22861399129863982tt353tt664

22861399129863982tt353
type: Position
type: ExactPosition
position: 353
reference: Q8RF47-1

22861399129863982tt61
type: Position
type: ExactPosition
position: 61
reference: Q8RF47-1

22861399129863982tt66
type: Position
type: ExactPosition
position: 66
reference: Q8RF47-1

22861399129863982tt95
type: Position
type: ExactPosition
position: 95
reference: Q8RF47-1

22861399129863982tt99
type: Position
type: ExactPosition
position: 99
reference: Q8RF47-1

22861399129863982tt119
type: Position
type: ExactPosition
position: 119
reference: Q8RF47-1

22861399129863982tt120
type: Position
type: ExactPosition
position: 120
reference: Q8RF47-1

22861399129863982tt132
type: Position
type: ExactPosition
position: 132
reference: Q8RF47-1

22861399129863982tt141
type: Position
type: ExactPosition
position: 141
reference: Q8RF47-1

22861399129863982tt159
type: Position
type: ExactPosition
position: 159
reference: Q8RF47-1

22861399129863982tt162
type: Position
type: ExactPosition
position: 162
reference: Q8RF47-1

22861399129863982tt174
type: Position
type: ExactPosition
position: 174
reference: Q8RF47-1

22861399129863982tt238
type: Position
type: ExactPosition
position: 238
reference: Q8RF47-1

22861399129863982tt255
type: Position
type: ExactPosition
position: 255
reference: Q8RF47-1

Q8RF47-1
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 76592
value: MKKIFDDIYVGSNIISKLNDYTEDFDKILIFSNETIADLYFEKFKSTLNEKDKVFYFAIKDGEEYKNIESILPVYDFMLENNFSRKSLIISLGGGVICDMGGYISATYMRGIEFIQVPTSLLAQVDASVGGKVAINHPKCKNMIGSFKNPYRVIIDVEFLKTLPKREFKSGMGELLKHSFLTKDKSYLEYIENNVEKIKNLDNEVLENIVEQSIRIKKHYVDIDPFEKGERAFLNLGHTYAHALESFFDYKAYTHGEAVSKGIIFDLELSLLRGQIDKEYLERARNIFKLFDIDTDLIYLPSDKFIPLMRKDKKNSFNKIITILLDSEGHLSKTEVKEDEIVKIIDKYKNNFLRASIDIGTNSCRLLIAEVEKDNENITFKKEIYKDLEIVKLGEDVNKNKFLKEEAIERTLKCLKKYRKIIDKYSIEEKNIICFATSATRDSTNKDYFIKKVFDETKIKINCISGDKEAYINFKGVISSFDRDFKDNILVFDIGGGSTEFTLGNMQGIEKKISLNIGSVRITEKFFLNNKLYNYSEENRIKAKDWVKENLKELEDFKKLNFSLIGVAGTTTTQVSVREKMEVYDSEKIHLSNLTSKEINDNLSLFIKNINKQEIKGLDPKRKDVIIGGTIILKEILDYFGKDFIIVSENDNLMGAILEGVENK

http://purl.uniprot.org/uniprot/Q8RF47#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q8RF47#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/Q8RF47#attribution-C51E2C39D87E23025D9EE4D32AEA3CE1
manual: true
evidence: ECO_0000250
source: P9WPX9

http://purl.uniprot.org/uniprot/Q8RF47#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

Q8RF94
type: Protein
reviewed: true
created: 2006-05-30
modified: 2023-05-03
version: 106
mnemonic: AROK_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIP6918AA3D5BEFE474
enzyme: http://purl.uniprot.org/enzyme/2.7.1.71
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIP59119D98617F4D3E
annotation: SIP98B11B49D06672CE
annotation: SIP7F496D5705535CEA
annotation: SIPFC726F001580E118
annotation: SIP9A20D37832B4F7F1
annotation: SIP0459CBDA53ABC5A8
annotation: SIP235CFABB37CE65A9
annotation: PRO_0000237881
annotation: SIPAAEAEA78F798694B
annotation: SIP1B1B3B3BFB71164B
annotation: SIP694872B0200F9938
annotation: SIPDDFE0310D7719E09
annotation: SIPE67CE39AEF2731C2
annotation: SIP2CA11288415E4D25
annotation: SIPF3D286D9D7278A86
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/57
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/418
classified with: http://purl.uniprot.org/keywords/460
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005829
classified with: GO_0005524
classified with: GO_0000287
classified with: GO_0004765
classified with: GO_0008652
classified with: GO_0009073
classified with: GO_0009423
classified with: GO_0016310
sequence: MKDNIALIGFMGSGKTTVGKLLAKTMDMKFVDIDKVIEAHEKKSINDIFHEKGQIYFRDLEREIILQESLKNDCVIATGGGSILDNENIKRLKETSFIVFLNATIECLYLRLKDNTTRPILNDVEDKRKLIEELLEKRKFLYQISADYIIDINEHTNIYETVDKIKEIYIIS
proteome: Chromosome

Q8RF94-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG0703
type: Resource
database: eggNOG
comment: Bacteria

cd00464
type: Resource
database: CDD
comment: SK
signature sequence match: CDD cd00464 match 1

http://purl.uniprot.org/gene3d/3.40.50.300
type: Resource
database: Gene3D
comment: P-loop containing nucleotide triphosphate hydrolases
signature sequence match: Gene3D 3.40.50.300 match 1
signature sequence match: Gene3D 3.40.50.300 match 2
signature sequence match: Gene3D 3.40.50.300 match 3

MF_00109
type: Resource
database: HAMAP
comment: Shikimate_kinase
signature sequence match: HAMAP MF 00109 match 1

IPR027417
type: Resource
database: InterPro
comment: P-loop_NTPase

IPR031322
type: Resource
database: InterPro
comment: Shikimate/glucono_kinase

IPR000623
type: Resource
database: InterPro
comment: Shikimate_kinase/TSH1

IPR023000
type: Resource
database: InterPro
comment: Shikimate_kinase_CS

PTHR21087
type: Resource
database: PANTHER
comment: SHIKIMATE KINASE
signature sequence match: PANTHER PTHR21087 match 1

PTHR21087:SF16
type: Resource
database: PANTHER
comment: SHIKIMATE KINASE 1, CHLOROPLASTIC
signature sequence match: PANTHER PTHR21087:SF16 match 1

PF01202
type: Resource
database: Pfam
comment: SKI
signature sequence match: Pfam PF01202 match 1

PR01100
type: Resource
database: PRINTS
comment: SHIKIMTKNASE

SSF52540
type: Resource
database: SUPFAM
comment: P-loop containing nucleoside triphosphate hydrolases
signature sequence match: SUPFAM SSF52540 match 1
signature sequence match: SUPFAM SSF52540 match 2

PS01128
type: Resource
database: PROSITE
comment: SHIKIMATE_KINASE
signature sequence match: PROSITE PS01128 match 1

SIP6918AA3D5BEFE474
type: Structured Name
full name: Shikimate kinase
short name: SK
ec name: 2.7.1.71

aroK
type: Gene
locus name: FN0822

SIP59119D98617F4D3E
type: Function Annotation
comment: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.

SIP7F496D5705535CEA
type: Cofactor Annotation
comment: Binds 1 Mg(2+) ion per subunit.
cofactor: CHEBI_18420

SIP9A20D37832B4F7F1
type: Subunit Annotation
comment: Monomer.

SIP235CFABB37CE65A9
type: Similarity Annotation
comment: Belongs to the shikimate kinase family.

PRO_0000237881
type: Chain Annotation
comment: Shikimate kinase
mass: 19948
range: 22861399130190894tt1tt172

22861399130190894tt1
type: Position
type: ExactPosition
position: 1
reference: MKDNIALIGFMGSGKTTVGKLLAKTMDMKFVDIDKVIEAHEKKSINDIFHEKGQIYFRDLEREIILQESLKNDCVIATGGGSILDNENIKRLKETSFIVFLNATIECLYLRLKDNTTRPILNDVEDKRKLIEELLEKRKFLYQISADYIIDINEHTNIYETVDKIKEIYIIS

22861399130190894tt172
type: Position
type: ExactPosition
position: 172
reference: MKDNIALIGFMGSGKTTVGKLLAKTMDMKFVDIDKVIEAHEKKSINDIFHEKGQIYFRDLEREIILQESLKNDCVIATGGGSILDNENIKRLKETSFIVFLNATIECLYLRLKDNTTRPILNDVEDKRKLIEELLEKRKFLYQISADYIIDINEHTNIYETVDKIKEIYIIS

22861399130190894tt12
type: Position
type: ExactPosition
position: 12
reference: MKDNIALIGFMGSGKTTVGKLLAKTMDMKFVDIDKVIEAHEKKSINDIFHEKGQIYFRDLEREIILQESLKNDCVIATGGGSILDNENIKRLKETSFIVFLNATIECLYLRLKDNTTRPILNDVEDKRKLIEELLEKRKFLYQISADYIIDINEHTNIYETVDKIKEIYIIS

22861399130190894tt17
type: Position
type: ExactPosition
position: 17
reference: MKDNIALIGFMGSGKTTVGKLLAKTMDMKFVDIDKVIEAHEKKSINDIFHEKGQIYFRDLEREIILQESLKNDCVIATGGGSILDNENIKRLKETSFIVFLNATIECLYLRLKDNTTRPILNDVEDKRKLIEELLEKRKFLYQISADYIIDINEHTNIYETVDKIKEIYIIS

22861399130190894tt16
type: Position
type: ExactPosition
position: 16
reference: MKDNIALIGFMGSGKTTVGKLLAKTMDMKFVDIDKVIEAHEKKSINDIFHEKGQIYFRDLEREIILQESLKNDCVIATGGGSILDNENIKRLKETSFIVFLNATIECLYLRLKDNTTRPILNDVEDKRKLIEELLEKRKFLYQISADYIIDINEHTNIYETVDKIKEIYIIS

22861399130190894tt34
type: Position
type: ExactPosition
position: 34
reference: MKDNIALIGFMGSGKTTVGKLLAKTMDMKFVDIDKVIEAHEKKSINDIFHEKGQIYFRDLEREIILQESLKNDCVIATGGGSILDNENIKRLKETSFIVFLNATIECLYLRLKDNTTRPILNDVEDKRKLIEELLEKRKFLYQISADYIIDINEHTNIYETVDKIKEIYIIS

22861399130190894tt58
type: Position
type: ExactPosition
position: 58
reference: MKDNIALIGFMGSGKTTVGKLLAKTMDMKFVDIDKVIEAHEKKSINDIFHEKGQIYFRDLEREIILQESLKNDCVIATGGGSILDNENIKRLKETSFIVFLNATIECLYLRLKDNTTRPILNDVEDKRKLIEELLEKRKFLYQISADYIIDINEHTNIYETVDKIKEIYIIS

22861399130190894tt80
type: Position
type: ExactPosition
position: 80
reference: MKDNIALIGFMGSGKTTVGKLLAKTMDMKFVDIDKVIEAHEKKSINDIFHEKGQIYFRDLEREIILQESLKNDCVIATGGGSILDNENIKRLKETSFIVFLNATIECLYLRLKDNTTRPILNDVEDKRKLIEELLEKRKFLYQISADYIIDINEHTNIYETVDKIKEIYIIS

22861399130190894tt118
type: Position
type: ExactPosition
position: 118
reference: MKDNIALIGFMGSGKTTVGKLLAKTMDMKFVDIDKVIEAHEKKSINDIFHEKGQIYFRDLEREIILQESLKNDCVIATGGGSILDNENIKRLKETSFIVFLNATIECLYLRLKDNTTRPILNDVEDKRKLIEELLEKRKFLYQISADYIIDINEHTNIYETVDKIKEIYIIS

22861399130190894tt138
type: Position
type: ExactPosition
position: 138
reference: MKDNIALIGFMGSGKTTVGKLLAKTMDMKFVDIDKVIEAHEKKSINDIFHEKGQIYFRDLEREIILQESLKNDCVIATGGGSILDNENIKRLKETSFIVFLNATIECLYLRLKDNTTRPILNDVEDKRKLIEELLEKRKFLYQISADYIIDINEHTNIYETVDKIKEIYIIS

substrate

MKDNIALIGFMGSGKTTVGKLLAKTMDMKFVDIDKVIEAHEKKSINDIFHEKGQIYFRDLEREIILQESLKNDCVIATGGGSILDNENIKRLKETSFIVFLNATIECLYLRLKDNTTRPILNDVEDKRKLIEELLEKRKFLYQISADYIIDINEHTNIYETVDKIKEIYIIS
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 19948

http://purl.uniprot.org/uniprot/Q8RF94#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q8RF94#attribution-721B6DCFEBB6A97B07CF9A0173E141ED
manual: true
evidence: ECO_0000255
source: MF_00109

Q8RH64
type: Protein
reviewed: true
created: 2002-11-15
modified: 2023-02-22
version: 101
mnemonic: AROQ_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIPDE3A72722C0C56D9
alternative name: SIP20E6E2C0F1892800
enzyme: http://purl.uniprot.org/enzyme/4.2.1.10
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIP6C32C7EAFA3FC18B
annotation: SIP98497D55F6F18374
annotation: SIP17C1C84180E41E22
annotation: SIP1EE4D1DA3548FEF0
annotation: SIP2EE43377FCE12567
annotation: PRO_0000159899
annotation: SIPDEB1180813192D2F
annotation: SIP0D6785E87744976F
annotation: SIP47B22644FEFC6F6A
annotation: SIP9191023211EA6832
annotation: SIPCCD1D6E05ABE365F
annotation: SIPB5AA958D4E90820A
annotation: SIP5871D24FEE48CD51
annotation: SIP457D60C061A0A389
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/57
classified with: http://purl.uniprot.org/keywords/456
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0003855
classified with: GO_0008652
classified with: GO_0009073
classified with: GO_0009423
classified with: GO_0019631
sequence: MKIMVINGPNLNMLGIREKNIYGTFSYDDLCKYIKDYPEYKDKNIEFEFLQSNVEGEIVNFIQEAYSKKYDGIILNAGGYTHTSVAIHDAIKAVSIPTVEVHISNIHAREDFRKVCVTSPACIGQITGLGKLGYILAVVYLIEYYNK
proteome: Chromosome

Q8RH64-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG0757
type: Resource
database: eggNOG
comment: Bacteria

cd00466
type: Resource
database: CDD
comment: DHQase_II
signature sequence match: CDD cd00466 match 1

http://purl.uniprot.org/gene3d/3.40.50.9100
type: Resource
database: Gene3D
comment: Dehydroquinase, class II
signature sequence match: Gene3D 3.40.50.9100 match 1

MF_00169
type: Resource
database: HAMAP
comment: AroQ
signature sequence match: HAMAP MF 00169 match 1

IPR001874
type: Resource
database: InterPro
comment: DHquinase_II

IPR018509
type: Resource
database: InterPro
comment: DHquinase_II_CS

IPR036441
type: Resource
database: InterPro
comment: DHquinase_II_sf

PTHR21272
type: Resource
database: PANTHER
comment: CATABOLIC 3-DEHYDROQUINASE
signature sequence match: PANTHER PTHR21272 match 1

PTHR21272:SF3
type: Resource
database: PANTHER
comment: CATABOLIC 3-DEHYDROQUINASE
signature sequence match: PANTHER PTHR21272:SF3 match 1

PF01220
type: Resource
database: Pfam
comment: DHquinase_II
signature sequence match: Pfam PF01220 match 1

PIRSF001399
type: Resource
database: PIRSF
comment: DHquinase_II
signature sequence match: PIRSF PIRSF001399 match 1

SSF52304
type: Resource
database: SUPFAM
comment: Type II 3-dehydroquinate dehydratase
signature sequence match: SUPFAM SSF52304 match 1

TIGR01088
type: Resource
database: TIGRFAMs
comment: aroQ
signature sequence match: TIGRFAMs TIGR01088 match 1

PS01029
type: Resource
database: PROSITE
comment: DEHYDROQUINASE_II
signature sequence match: PROSITE PS01029 match 1

SIPDE3A72722C0C56D9
type: Structured Name
full name: 3-dehydroquinate dehydratase
short name: 3-dehydroquinase
ec name: 4.2.1.10

SIP20E6E2C0F1892800
type: Structured Name
full name: Type II DHQase

aroQ
type: Gene
locus name: FN0046

SIP6C32C7EAFA3FC18B
type: Function Annotation
comment: Catalyzes a trans-dehydration via an enolate intermediate.

SIP1EE4D1DA3548FEF0
type: Subunit Annotation
comment: Homododecamer.

SIP2EE43377FCE12567
type: Similarity Annotation
comment: Belongs to the type-II 3-dehydroquinase family.

PRO_0000159899
type: Chain Annotation
comment: 3-dehydroquinate dehydratase
mass: 16652
range: 22861399163548718tt1tt147

22861399163548718tt1
type: Position
type: ExactPosition
position: 1
reference: MKIMVINGPNLNMLGIREKNIYGTFSYDDLCKYIKDYPEYKDKNIEFEFLQSNVEGEIVNFIQEAYSKKYDGIILNAGGYTHTSVAIHDAIKAVSIPTVEVHISNIHAREDFRKVCVTSPACIGQITGLGKLGYILAVVYLIEYYNK

22861399163548718tt147
type: Position
type: ExactPosition
position: 147
reference: MKIMVINGPNLNMLGIREKNIYGTFSYDDLCKYIKDYPEYKDKNIEFEFLQSNVEGEIVNFIQEAYSKKYDGIILNAGGYTHTSVAIHDAIKAVSIPTVEVHISNIHAREDFRKVCVTSPACIGQITGLGKLGYILAVVYLIEYYNK

SIPDEB1180813192D2F
type: Active Site Annotation
comment: Proton acceptor
range: 22861399163548718tt22tt22

22861399163548718tt22
type: Position
type: ExactPosition
position: 22
reference: MKIMVINGPNLNMLGIREKNIYGTFSYDDLCKYIKDYPEYKDKNIEFEFLQSNVEGEIVNFIQEAYSKKYDGIILNAGGYTHTSVAIHDAIKAVSIPTVEVHISNIHAREDFRKVCVTSPACIGQITGLGKLGYILAVVYLIEYYNK

SIP0D6785E87744976F
type: Active Site Annotation
comment: Proton donor
range: 22861399163548718tt102tt102

22861399163548718tt102
type: Position
type: ExactPosition
position: 102
reference: MKIMVINGPNLNMLGIREKNIYGTFSYDDLCKYIKDYPEYKDKNIEFEFLQSNVEGEIVNFIQEAYSKKYDGIILNAGGYTHTSVAIHDAIKAVSIPTVEVHISNIHAREDFRKVCVTSPACIGQITGLGKLGYILAVVYLIEYYNK

22861399163548718tt76
type: Position
type: ExactPosition
position: 76
reference: MKIMVINGPNLNMLGIREKNIYGTFSYDDLCKYIKDYPEYKDKNIEFEFLQSNVEGEIVNFIQEAYSKKYDGIILNAGGYTHTSVAIHDAIKAVSIPTVEVHISNIHAREDFRKVCVTSPACIGQITGLGKLGYILAVVYLIEYYNK

22861399163548718tt82
type: Position
type: ExactPosition
position: 82
reference: MKIMVINGPNLNMLGIREKNIYGTFSYDDLCKYIKDYPEYKDKNIEFEFLQSNVEGEIVNFIQEAYSKKYDGIILNAGGYTHTSVAIHDAIKAVSIPTVEVHISNIHAREDFRKVCVTSPACIGQITGLGKLGYILAVVYLIEYYNK

22861399163548718tt89
type: Position
type: ExactPosition
position: 89
reference: MKIMVINGPNLNMLGIREKNIYGTFSYDDLCKYIKDYPEYKDKNIEFEFLQSNVEGEIVNFIQEAYSKKYDGIILNAGGYTHTSVAIHDAIKAVSIPTVEVHISNIHAREDFRKVCVTSPACIGQITGLGKLGYILAVVYLIEYYNK

22861399163548718tt103
type: Position
type: ExactPosition
position: 103
reference: MKIMVINGPNLNMLGIREKNIYGTFSYDDLCKYIKDYPEYKDKNIEFEFLQSNVEGEIVNFIQEAYSKKYDGIILNAGGYTHTSVAIHDAIKAVSIPTVEVHISNIHAREDFRKVCVTSPACIGQITGLGKLGYILAVVYLIEYYNK

22861399163548718tt104
type: Position
type: ExactPosition
position: 104
reference: MKIMVINGPNLNMLGIREKNIYGTFSYDDLCKYIKDYPEYKDKNIEFEFLQSNVEGEIVNFIQEAYSKKYDGIILNAGGYTHTSVAIHDAIKAVSIPTVEVHISNIHAREDFRKVCVTSPACIGQITGLGKLGYILAVVYLIEYYNK

22861399163548718tt113
type: Position
type: ExactPosition
position: 113
reference: MKIMVINGPNLNMLGIREKNIYGTFSYDDLCKYIKDYPEYKDKNIEFEFLQSNVEGEIVNFIQEAYSKKYDGIILNAGGYTHTSVAIHDAIKAVSIPTVEVHISNIHAREDFRKVCVTSPACIGQITGLGKLGYILAVVYLIEYYNK

SIP457D60C061A0A389
type: Site Annotation
comment: Transition state stabilizer
range: 22861399163548718tt17tt17

22861399163548718tt17
type: Position
type: ExactPosition
position: 17
reference: MKIMVINGPNLNMLGIREKNIYGTFSYDDLCKYIKDYPEYKDKNIEFEFLQSNVEGEIVNFIQEAYSKKYDGIILNAGGYTHTSVAIHDAIKAVSIPTVEVHISNIHAREDFRKVCVTSPACIGQITGLGKLGYILAVVYLIEYYNK

substrate

MKIMVINGPNLNMLGIREKNIYGTFSYDDLCKYIKDYPEYKDKNIEFEFLQSNVEGEIVNFIQEAYSKKYDGIILNAGGYTHTSVAIHDAIKAVSIPTVEVHISNIHAREDFRKVCVTSPACIGQITGLGKLGYILAVVYLIEYYNK
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 16652

http://purl.uniprot.org/uniprot/Q8RH64#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q8RH64#attribution-39B1EE6DDC12334499D3CAF499BBB57E
manual: true
evidence: ECO_0000255
source: MF_00169

P58824
type: Protein
reviewed: true
created: 2002-05-27
modified: 2023-02-22
version: 103
mnemonic: ASNA_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIPBEAD1D37689E28D9
alternative name: SIP87C2FFBA52385C90
enzyme: http://purl.uniprot.org/enzyme/6.3.1.1
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIPB603D9F7BA4558C9
annotation: SIP5CE8EB0098C554CD
annotation: SIP441203DB2AB0B16A
annotation: SIP716EE4E7306D9AC3
annotation: PRO_0000195876
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/61
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/436
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005829
classified with: GO_0004071
classified with: GO_0005524
classified with: GO_0006529
classified with: GO_0070981
sequence: P58824-1
proteome: Chromosome

P58824-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG2502
type: Resource
database: eggNOG
comment: Bacteria

MF_00555
type: Resource
database: HAMAP
comment: AsnA
signature sequence match: HAMAP MF 00555 match 1

IPR006195
type: Resource
database: InterPro
comment: aa-tRNA-synth_II

IPR045864
type: Resource
database: InterPro
comment: aa-tRNA-synth_II/BPL/LPL

IPR004618
type: Resource
database: InterPro
comment: AsnA

PTHR30073
type: Resource
database: PANTHER
comment: ASPARTATE--AMMONIA LIGASE
signature sequence match: PANTHER PTHR30073 match 1

PTHR30073:SF5
type: Resource
database: PANTHER
comment: ASPARTATE--AMMONIA LIGASE
signature sequence match: PANTHER PTHR30073:SF5 match 1

PF03590
type: Resource
database: Pfam
comment: AsnA
signature sequence match: Pfam PF03590 match 1

PIRSF001555
type: Resource
database: PIRSF
comment: Asp_ammon_ligase
signature sequence match: PIRSF PIRSF001555 match 1

SSF55681
type: Resource
database: SUPFAM
comment: Class II aaRS and biotin synthetases
signature sequence match: SUPFAM SSF55681 match 1

TIGR00669
type: Resource
database: TIGRFAMs
comment: asnA
signature sequence match: TIGRFAMs TIGR00669 match 1

PS50862
type: Resource
database: PROSITE
comment: AA_TRNA_LIGASE_II
signature sequence match: PROSITE PS50862 match 1

SIPBEAD1D37689E28D9
type: Structured Name
full name: Aspartate--ammonia ligase
ec name: 6.3.1.1

SIP87C2FFBA52385C90
type: Structured Name
full name: Asparagine synthetase A

asnA
type: Gene
locus name: FN0776

SIP716EE4E7306D9AC3
type: Similarity Annotation
comment: Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.

PRO_0000195876
type: Chain Annotation
comment: Aspartate--ammonia ligase
mass: 37974
range: 22576513714107438tt1tt327

22576513714107438tt1
type: Position
type: ExactPosition
position: 1
reference: P58824-1

22576513714107438tt327
type: Position
type: ExactPosition
position: 327
reference: P58824-1

P58824-1
type: Simple Sequence
modified: 2002-05-27
version: 1
mass: 37974
value: MAYISSLDILETEIAIKKVKDFFESHLSKELDLLRVSAPLFVIPESGLNDNLNGTERPVSFDTKSGERVEIVHSLAKWKRMALYRYNIENDKGIYTDMNAIRRDEDTDFIHSYYVDQWDWEKIISKEDRNEEYLKDVVRKIYSVFKKTEEYITTEYPKLTKKLPEEITFITAQELENKYPNLTPKNREHAAAKEYGAIFLMKIGGKLSSGEKHDGRAPDYDDWDLNGDIIFNYPLLGIGLELSSMGIRVDEKSLDEQLKIANCEDRRSLPYHQMILNKVLPYTIGGGIGQSRICMFFLDKLHIGEVQASIWSQEVHEICRQMNIKLL

http://purl.uniprot.org/uniprot/P58824#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/P58824#attribution-8ACC0DEE7D510545D212DFD25B79A0D1
manual: true
evidence: ECO_0000255
source: MF_00555

P21903
type: Protein
reviewed: true
created: 1991-05-01
modified: 2023-02-22
version: 123
mnemonic: ATP6_PROMO
old mnemonic: ATNA_PROMO
citation: http://purl.uniprot.org/citations/2174545
citation: http://purl.uniprot.org/citations/1386022
citation: http://purl.uniprot.org/citations/2170948
citation: http://purl.uniprot.org/citations/1533602
conflicting sequence: SIP114C58EC6C0326F8
conflicting sequence: SIP719069029880549D
recommended name: SIP48851BA5A97291E3
alternative name: SIPAAE750EF5DEF8F79
alternative name: SIPB64859FA922E406A
organism: http://purl.uniprot.org/taxonomy/2333
annotation: SIPE9043F10F66DE7D0
annotation: SIP5CE00348F90BAF19
annotation: SIPBA71ED15F6136D56
annotation: SIP999D6C11435C963B
annotation: SIP4483E17CFC40300A
annotation: PRO_0000082065
annotation: SIP9ADD856DC8B111AB
annotation: SIP816087A271D7AFF0
annotation: SIPC1A0ADEFDC848B81
annotation: SIPC509199DFF905C79
annotation: SIP7AD7EFEB3458FABC
annotation: SIPF31E618D8A5C2322
annotation: SIPCF131A2535DFA01D
annotation: SIPEB671892D73B090E
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/66
classified with: http://purl.uniprot.org/keywords/1003
classified with: http://purl.uniprot.org/keywords/138
classified with: http://purl.uniprot.org/keywords/739
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0005886
classified with: GO_0045263
classified with: GO_0046933
classified with: GO_0006814
sequence: P21903-1

P21903-citation-2174545
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

DSM 2376 / Gra Succ2
type: Strain

P21903-citation-1386022
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

P21903-citation-2170948
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

P21903-citation-1533602
type: Citation Statement
scope: DISCUSSION OF SEQUENCE

3.A.2.1.2
type: Resource
database: TCDB
comment: the h+- or na+-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

cd00310
type: Resource
database: CDD
comment: ATP-synt_Fo_a_6
signature sequence match: CDD cd00310 match 1

http://purl.uniprot.org/gene3d/1.20.120.220
type: Resource
database: Gene3D
comment: ATP synthase, F0 complex, subunit A
signature sequence match: Gene3D 1.20.120.220 match 1

MF_01393
type: Resource
database: HAMAP
comment: ATP_synth_a_bact
signature sequence match: HAMAP MF 01393 match 1

IPR045082
type: Resource
database: InterPro
comment: ATP_syn_F0_a_bact/chloroplast

IPR000568
type: Resource
database: InterPro
comment: ATP_synth_F0_asu

IPR023011
type: Resource
database: InterPro
comment: ATP_synth_F0_asu_AS

IPR035908
type: Resource
database: InterPro
comment: F0_ATP_A_sf

PTHR42823
type: Resource
database: PANTHER
comment: ATP SYNTHASE SUBUNIT A, CHLOROPLASTIC
signature sequence match: PANTHER PTHR42823 match 1

PTHR42823:SF3
type: Resource
database: PANTHER
comment: ATP SYNTHASE SUBUNIT A, CHLOROPLASTIC
signature sequence match: PANTHER PTHR42823:SF3 match 1

PF00119
type: Resource
database: Pfam
comment: ATP-synt_A
signature sequence match: Pfam PF00119 match 1

PR00123
type: Resource
database: PRINTS
comment: ATPASEA

SSF81336
type: Resource
database: SUPFAM
comment: F1F0 ATP synthase subunit A
signature sequence match: SUPFAM SSF81336 match 1

TIGR01131
type: Resource
database: TIGRFAMs
comment: ATP_synt_6_or_A
signature sequence match: TIGRFAMs TIGR01131 match 1

PS00449
type: Resource
database: PROSITE
comment: ATPASE_A
signature sequence match: PROSITE PS00449 match 1

SIP48851BA5A97291E3
type: Structured Name
full name: ATP synthase subunit a, sodium ion specific

SIPAAE750EF5DEF8F79
type: Structured Name
full name: ATP synthase F0 sector subunit a

SIPB64859FA922E406A
type: Structured Name
full name: F-ATPase subunit 6

atpB
type: Gene
alternative label: uncB

SIPE9043F10F66DE7D0
type: Function Annotation
comment: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.

SIP5CE00348F90BAF19
type: Subunit Annotation
comment: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.

SIP999D6C11435C963B
type: Annotation
comment: The ATPase of P.modestum is of special interest because it uses sodium ions instead of protons as the physiological coupling ion.

SIP4483E17CFC40300A
type: Similarity Annotation
comment: Belongs to the ATPase A chain family.

PRO_0000082065
type: Chain Annotation
comment: ATP synthase subunit a, sodium ion specific
mass: 32224
range: 22573185131098926tt1tt289

22573185131098926tt1
type: Position
type: ExactPosition
position: 1
reference: P21903-1

22573185131098926tt289
type: Position
type: ExactPosition
position: 289
reference: P21903-1

SIP9ADD856DC8B111AB
type: Transmembrane Annotation
comment: Helical
range: 22573185131098926tt7tt27

22573185131098926tt7
type: Position
type: ExactPosition
position: 7
reference: P21903-1

22573185131098926tt27
type: Position
type: ExactPosition
position: 27
reference: P21903-1

SIP816087A271D7AFF0
type: Transmembrane Annotation
comment: Helical
range: 22573185131098926tt65tt85

22573185131098926tt65
type: Position
type: ExactPosition
position: 65
reference: P21903-1

22573185131098926tt85
type: Position
type: ExactPosition
position: 85
reference: P21903-1

SIPC1A0ADEFDC848B81
type: Transmembrane Annotation
comment: Helical
range: 22573185131098926tt129tt149

22573185131098926tt129
type: Position
type: ExactPosition
position: 129
reference: P21903-1

22573185131098926tt149
type: Position
type: ExactPosition
position: 149
reference: P21903-1

SIPC509199DFF905C79
type: Transmembrane Annotation
comment: Helical
range: 22573185131098926tt169tt189

22573185131098926tt169
type: Position
type: ExactPosition
position: 169
reference: P21903-1

22573185131098926tt189
type: Position
type: ExactPosition
position: 189
reference: P21903-1

SIP7AD7EFEB3458FABC
type: Transmembrane Annotation
comment: Helical
range: 22573185131098926tt231tt251

22573185131098926tt231
type: Position
type: ExactPosition
position: 231
reference: P21903-1

22573185131098926tt251
type: Position
type: ExactPosition
position: 251
reference: P21903-1

SIPF31E618D8A5C2322
type: Transmembrane Annotation
comment: Helical
range: 22573185131098926tt257tt277

22573185131098926tt257
type: Position
type: ExactPosition
position: 257
reference: P21903-1

22573185131098926tt277
type: Position
type: ExactPosition
position: 277
reference: P21903-1

SIPCF131A2535DFA01D
type: Sequence Conflict Annotation
conflicting sequence: SIP114C58EC6C0326F8
substitution: I
range: 22573185131098926tt114tt114

22573185131098926tt114
type: Position
type: ExactPosition
position: 114
reference: P21903-1

SIPEB671892D73B090E
type: Sequence Conflict Annotation
conflicting sequence: SIP719069029880549D
substitution: I
range: 22573185131098926tt114tt114

P21903-1
type: Simple Sequence
modified: 1991-05-01
version: 1
mass: 32224
value: MKKMGPIILAVVIAIGTFALKMMGVIGFKTPPLVEGPKIMFYVPLPEAMHDFPFAMEMASGVYGFPVTITVISTWFVMLFLIMVFRWSSKNLEVVPERKQAFFETIYGFLDDLYGQLLGNWKKKYFTYIGTLFLFLLISNIVSFFPIPGFSSENGVFSIAPALRTPTADLNTTVGLALLTTYSFIAASFRTSGFFGFFKGLFEPMPLMFPINLAGEFAKPTNISIRLFGNMFAGMVILGLLYKAAPVLIPAPLHLYFDLFSGVVQSFVFIMLTMVYIQGSIGDAEYLED

http://purl.uniprot.org/uniprot/P21903#attribution-D994E701E2B83728CB99F3F29F0E9616
manual: true
evidence: ECO_0000255
source: MF_01393

http://purl.uniprot.org/uniprot/P21903#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

Q8RGE0
type: Protein
reviewed: true
created: 2006-05-30
modified: 2023-05-03
version: 126
mnemonic: ATPA_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIPBE7712CDD879D1B2
alternative name: SIP605D291825F99072
alternative name: SIPA3FE03A31043C3FE
enzyme: http://purl.uniprot.org/enzyme/7.1.2.2
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIP482085F086A65CF0
annotation: SIP6B2A5BA5F90F3DFD
annotation: SIP55BB38167BE63EA2
annotation: SIPF27B194FE915C466
annotation: SIPB59466A7E0B6E95E
annotation: PRO_0000238252
annotation: SIPCAF576B43F0C6274
annotation: SIP839B58C2667CD286
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/997
classified with: http://purl.uniprot.org/keywords/139
classified with: http://purl.uniprot.org/keywords/375
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/1278
classified with: GO_0005886
classified with: GO_0045261
classified with: GO_0043531
classified with: GO_0005524
classified with: GO_0046933
classified with: GO_0046961
classified with: GO_0015986
sequence: Q8RGE0-1
proteome: Chromosome

Q8RGE0-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

6Q45
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 3.60
chain sequence mapping: PDB 6Q45 tt1tt500
chain sequence mapping: PDB 6Q45 tt1tt462
chain sequence mapping: PDB 6Q45 tt1tt134
chain sequence mapping: PDB 6Q45 tt1tt282

PDB 6Q45 tt1tt500
chain: A/B/C/I/J/K=1-500

Q8RGE0
type: Resource
database: IntAct
comment: 4

COG0056
type: Resource
database: eggNOG
comment: Bacteria

cd18113
type: Resource
database: CDD
comment: ATP-synt_F1_alpha_C
signature sequence match: CDD cd18113 match 1

cd18116
type: Resource
database: CDD
comment: ATP-synt_F1_alpha_N
signature sequence match: CDD cd18116 match 1

cd01132
type: Resource
database: CDD
comment: F1-ATPase_alpha_CD
signature sequence match: CDD cd01132 match 1

http://purl.uniprot.org/gene3d/1.20.150.20
type: Resource
database: Gene3D
comment: ATP synthase alpha/beta chain, C-terminal domain
signature sequence match: Gene3D 1.20.150.20 match 1

MF_01346
type: Resource
database: HAMAP
comment: ATP_synth_alpha_bact
signature sequence match: HAMAP MF 01346 match 1

IPR023366
type: Resource
database: InterPro
comment: ATP_synth_asu-like_sf

IPR000793
type: Resource
database: InterPro
comment: ATP_synth_asu_C

IPR038376
type: Resource
database: InterPro
comment: ATP_synth_asu_C_sf

IPR033732
type: Resource
database: InterPro
comment: ATP_synth_F1_a_nt-bd_dom

IPR005294
type: Resource
database: InterPro
comment: ATP_synth_F1_asu

IPR020003
type: Resource
database: InterPro
comment: ATPase_a/bsu_AS

IPR004100
type: Resource
database: InterPro
comment: ATPase_F1/V1/A1_a/bsu_N

IPR036121
type: Resource
database: InterPro
comment: ATPase_F1/V1/A1_a/bsu_N_sf

IPR000194
type: Resource
database: InterPro
comment: ATPase_F1/V1/A1_a/bsu_nucl-bd

PTHR48082
type: Resource
database: PANTHER
comment: ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL
signature sequence match: PANTHER PTHR48082 match 1

PTHR48082:SF2
type: Resource
database: PANTHER
comment: ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL
signature sequence match: PANTHER PTHR48082:SF2 match 1

PF00006
type: Resource
database: Pfam
comment: ATP-synt_ab
signature sequence match: Pfam PF00006 match 1

PF00306
type: Resource
database: Pfam
comment: ATP-synt_ab_C
signature sequence match: Pfam PF00306 match 1

PF02874
type: Resource
database: Pfam
comment: ATP-synt_ab_N
signature sequence match: Pfam PF02874 match 1

PIRSF039088
type: Resource
database: PIRSF
comment: F_ATPase_subunit_alpha
signature sequence match: PIRSF PIRSF039088 match 1

SSF47917
type: Resource
database: SUPFAM
comment: C-terminal domain of alpha and beta subunits of F1 ATP synthase
signature sequence match: SUPFAM SSF47917 match 1

SSF50615
type: Resource
database: SUPFAM
comment: N-terminal domain of alpha and beta subunits of F1 ATP synthase
signature sequence match: SUPFAM SSF50615 match 1

TIGR00962
type: Resource
database: TIGRFAMs
comment: atpA
signature sequence match: TIGRFAMs TIGR00962 match 1

PS00152
type: Resource
database: PROSITE
comment: ATPASE_ALPHA_BETA
signature sequence match: PROSITE PS00152 match 1

SIPBE7712CDD879D1B2
type: Structured Name
full name: ATP synthase subunit alpha
ec name: 7.1.2.2

SIP605D291825F99072
type: Structured Name
full name: ATP synthase F1 sector subunit alpha

SIPA3FE03A31043C3FE
type: Structured Name
full name: F-ATPase subunit alpha

atpA
type: Gene
locus name: FN0360

SIP482085F086A65CF0
type: Function Annotation
comment: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

SIP55BB38167BE63EA2
type: Subunit Annotation
comment: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.

SIPB59466A7E0B6E95E
type: Similarity Annotation
comment: Belongs to the ATPase alpha/beta chains family.

PRO_0000238252
type: Chain Annotation
comment: ATP synthase subunit alpha
mass: 54767
range: 22861399147753518tt1tt500

22861399147753518tt1
type: Position
type: ExactPosition
position: 1
reference: Q8RGE0-1

22861399147753518tt500
type: Position
type: ExactPosition
position: 500
reference: Q8RGE0-1

22861399147753518tt169
type: Position
type: ExactPosition
position: 169
reference: Q8RGE0-1

22861399147753518tt176
type: Position
type: ExactPosition
position: 176
reference: Q8RGE0-1

SIP839B58C2667CD286
type: Site Annotation
comment: Required for activity
range: 22861399147753518tt362tt362

22861399147753518tt362
type: Position
type: ExactPosition
position: 362
reference: Q8RGE0-1

Q8RGE0-1
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 54767
value: MNIRPEEVSSIIKKEIDNYKKSLEIKTSGTVLEVGDGIARIFGLSNVMSGELLEFPHGVMGMALNLEEDNVGAVILGNASLIKEGDEVRATGKVVSVPAGEDLLGRVINALGDPIDGKGEIHVDKYMPIERKASGIIARQPVSEPLQTGIKSIDGMVPIGRGQRELIIGDRQTGKTAIAIDTIINQKGQDVKCIYVAIGQKRSTVAQIYKKLSDLGCMDYTIIVAATASEAAPLQYMAPYSGVAIGEYFMEKGEHVLIIYDDLSKHAVAYREMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDELGGGSITALPIIETQAGDVSAYIPTNVISITDGQIFLESQLFNSGFRPAINAGISVSRVGGAAQIKAMKQVASKVKLELAQYTELLTFAQFGSDLDKATKAQLERGHRIMEILKQPQYHPFAVERQVVSFYIVINGHLDDIEVSKVRRFEKELLDYLKANTNILTEIADKKALDKDLEEKLKESIANFKKSFN

http://purl.uniprot.org/uniprot/Q8RGE0#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q8RGE0#attribution-5C1C7D08C5C30A92BBCA3D89004F22BF
manual: true
evidence: ECO_0000255
source: MF_01346

P29706
type: Protein
reviewed: true
created: 1993-04-01
modified: 2023-05-03
version: 139
mnemonic: ATPA_PROMO
citation: SIP88792F94F71C70A8
citation: http://purl.uniprot.org/citations/1386022
citation: http://purl.uniprot.org/citations/7556212
citation: http://purl.uniprot.org/citations/8422943
conflicting sequence: SIPEB78BB5144A49836
conflicting sequence: SIP04D985EC566FAAA3
recommended name: SIPF72C54131C95A20A
alternative name: SIPEBAD237A76E98DA6
enzyme: http://purl.uniprot.org/enzyme/7.2.2.1
organism: http://purl.uniprot.org/taxonomy/2333
annotation: SIP266017438C069DE0
annotation: SIP9D8A7B33893CC71E
annotation: SIPF23B0CD05B2C0FCA
annotation: SIP5C0CBE42B16558D4
annotation: SIP327CB884BD72C41A
annotation: SIP185D372E7602668F
annotation: SIPD1AE6FFF74FDB9C7
annotation: PRO_0000144343
annotation: SIP015ABFE7CBAD7266
annotation: SIP78BB5E3A17F57F52
annotation: SIP37968A46F9E6C51C
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/1003
classified with: http://purl.uniprot.org/keywords/139
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/739
classified with: http://purl.uniprot.org/keywords/1278
classified with: GO_0005886
classified with: GO_0045261
classified with: GO_0005524
classified with: GO_0046933
classified with: GO_0046932
classified with: GO_0046962
sequence: P29706-1

SIP88792F94F71C70A8
type: Submission Citation
author: Krumholz L.R.
author: Esser U.
author: Simoni R.D.
date: 1991-03
submitted to: EMBL/GenBank/DDBJ

P29706-citation-SIP88792F94F71C70A8
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

DSM 2376 / Gra Succ2
type: Strain

P29706-citation-1386022
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 140-269

P29706-citation-7556212
type: Citation Statement
scope: SEQUENCE REVISION TO 466-500

P29706-citation-8422943
type: Citation Statement
scope: PROTEIN SEQUENCE OF 1-7

EMBL CAA41372.1
comment: Frameshift.

EMBL CAA46898.1
comment: Sequence problems.

SIPF72C54131C95A20A
type: Structured Name
full name: ATP synthase subunit alpha, sodium ion specific
ec name: 7.2.2.1

SIPEBAD237A76E98DA6
type: Structured Name
full name: Na(+)-translocating ATPase subunit alpha

atpA
type: Gene
alternative label: uncA

SIP266017438C069DE0
type: Function Annotation
comment: Produces ATP from ADP in the presence of a sodium ion gradient across the membrane. The alpha chain is a regulatory subunit.

SIPF23B0CD05B2C0FCA
type: Subunit Annotation
comment: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.

SIP327CB884BD72C41A
type: Annotation
comment: The ATPase of P.modestum is of special interest because it uses sodium ions instead of protons as the physiological coupling ion.

SIP185D372E7602668F
type: Similarity Annotation
comment: Belongs to the ATPase alpha/beta chains family.

PRO_0000144343
type: Chain Annotation
comment: ATP synthase subunit alpha, sodium ion specific
mass: 54472
range: 22573219457283630tt1tt500

22573219457283630tt1
type: Position
type: ExactPosition
position: 1
reference: P29706-1

22573219457283630tt500
type: Position
type: ExactPosition
position: 500
reference: P29706-1

22573219457283630tt169
type: Position
type: ExactPosition
position: 169
reference: P29706-1

22573219457283630tt176
type: Position
type: ExactPosition
position: 176
reference: P29706-1

SIP78BB5E3A17F57F52
type: Site Annotation
comment: Required for activity
range: 22573219457283630tt362tt362

22573219457283630tt362
type: Position
type: ExactPosition
position: 362
reference: P29706-1

SIP37968A46F9E6C51C
type: Sequence Conflict Annotation
conflicting sequence: SIPEB78BB5144A49836
substitution: Y
range: 22573219457283630tt150tt150

22573219457283630tt150
type: Position
type: ExactPosition
position: 150
reference: P29706-1

P29706-1
type: Simple Sequence
modified: 2004-12-07
version: 2
mass: 54472
value: MKIRPEEISGIIKTEIENYKKSLDVKTSGSVVQVGDGIARIYGLSNAKAGELLEFPNGITGMALNLEENNVGAVILGDPTGVKEGDEVRATGQIAAVGAGEALLGRVVNSLGEPIDGKGELKTEKMMPLDRKAYGIISRKPVHEPLQTGIKSIDGMVPIGRGQRELIIGDRQTGKTAVALDAIINQKDTGVKCIYVAIGQKRSTVAQIVKRLEDAGALEYTIVVAATASESAPLQYMAPYTGVSMGEYFMDKGEHVLIVYDDLSKHAVAYREMSLLLKRPPGREAFPGDVFYLHSRLLERAAKLSDEIGAGSITALPIIETQAGDVSAYIPTNVISITDGQIFLDSQLFNSGFRPAINAGISVSRVGGAAQIKAMKQVAAQVKLELAQYNELLTFAQFGSDLDKATLAQLERGHRIMEILKQEQYKPFVVEEQVVSFFTVINGYLDDIAIDQVRRFEKELLEELKDNTTILAEIVEKKAIKEDLDAKLRKAIEDFKKKFS

http://purl.uniprot.org/uniprot/P29706#attribution-5C1C7D08C5C30A92BBCA3D89004F22BF
manual: true
evidence: ECO_0000255
source: MF_01346

http://purl.uniprot.org/uniprot/P29706#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

Q8RGE2
type: Protein
reviewed: true
created: 2006-10-31
modified: 2023-05-03
version: 133
mnemonic: ATPB_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIPCABF2B7C796C67AF
alternative name: SIP54BDE05048B44533
alternative name: SIPE5DC476874342920
enzyme: http://purl.uniprot.org/enzyme/7.1.2.2
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIPC72402561F30C571
annotation: SIP33114F336C9CEC8E
annotation: SIPDB77C0C92BEB4898
annotation: SIPF2427CED11876AA5
annotation: SIP2B903281EC6451E1
annotation: PRO_0000254266
annotation: SIP2FBE7285CFEB3155
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/997
classified with: http://purl.uniprot.org/keywords/139
classified with: http://purl.uniprot.org/keywords/375
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/1278
classified with: GO_0005886
classified with: GO_0045261
classified with: GO_0005524
classified with: GO_0046933
classified with: GO_0046961
sequence: Q8RGE2-1
proteome: Chromosome

Q8RGE2-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

PDB 6Q45 tt1tt462
chain: D/E/F/L/M/N=1-462

Q8RGE2
type: Resource
database: IntAct
comment: 1

COG0055
type: Resource
database: eggNOG
comment: Bacteria

cd18110
type: Resource
database: CDD
comment: ATP-synt_F1_beta_C
signature sequence match: CDD cd18110 match 1

cd18115
type: Resource
database: CDD
comment: ATP-synt_F1_beta_N
signature sequence match: CDD cd18115 match 1

cd01133
type: Resource
database: CDD
comment: F1-ATPase_beta_CD
signature sequence match: CDD cd01133 match 1

MF_01347
type: Resource
database: HAMAP
comment: ATP_synth_beta_bact
signature sequence match: HAMAP MF 01347 match 1

IPR003593
type: Resource
database: InterPro
comment: AAA+_ATPase

IPR005722
type: Resource
database: InterPro
comment: ATP_synth_F1_bsu

IPR024034
type: Resource
database: InterPro
comment: ATPase_F1/V1_b/a_C

PTHR15184
type: Resource
database: PANTHER
comment: ATP SYNTHASE
signature sequence match: PANTHER PTHR15184 match 1

PTHR15184:SF71
type: Resource
database: PANTHER
comment: ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL
signature sequence match: PANTHER PTHR15184:SF71 match 1

PIRSF039072
type: Resource
database: PIRSF
comment: ATPase_subunit_beta
signature sequence match: PIRSF PIRSF039072 match 1

SM00382
type: Resource
database: SMART
comment: AAA
signature sequence match: SMART SM00382 match 1
signature sequence match: SMART SM00382 match 2

TIGR01039
type: Resource
database: TIGRFAMs
comment: atpD
signature sequence match: TIGRFAMs TIGR01039 match 1

SIPCABF2B7C796C67AF
type: Structured Name
full name: ATP synthase subunit beta
ec name: 7.1.2.2

SIP54BDE05048B44533
type: Structured Name
full name: ATP synthase F1 sector subunit beta

SIPE5DC476874342920
type: Structured Name
full name: F-ATPase subunit beta

atpD
type: Gene
locus name: FN0358

SIPC72402561F30C571
type: Function Annotation
comment: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

SIPDB77C0C92BEB4898
type: Subunit Annotation
comment: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.

SIP2B903281EC6451E1
type: Similarity Annotation
comment: Belongs to the ATPase alpha/beta chains family.

PRO_0000254266
type: Chain Annotation
comment: ATP synthase subunit beta
mass: 50219
range: 22861399147754030tt1tt462

22861399147754030tt1
type: Position
type: ExactPosition
position: 1
reference: Q8RGE2-1

22861399147754030tt462
type: Position
type: ExactPosition
position: 462
reference: Q8RGE2-1

22861399147754030tt149
type: Position
type: ExactPosition
position: 149
reference: Q8RGE2-1

22861399147754030tt156
type: Position
type: ExactPosition
position: 156
reference: Q8RGE2-1

Q8RGE2-1
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 50219
value: MNKGTITQIISAVVDIAFKDELPAIYNALKVKLEDKELVLEVEQHLGNNVVRTVAMDSTDGLKRGMEVIDTGKPITIPVGKAVLGRILNVLGEPVDNQGPLNAETFLPIHREAPEFDDLETETEIFETGIKVIDLLAPYIKGGKIGLFGGAGVGKTVLIMELINNIAKGHGGISVFAGVGERTREGRDLYGEMTESGVITKTALVYGQMNEPPGARLRVALTGLTVAENFRDKDGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPNLATEMGALQERITSTKSGSITSVQAVYVPADDLTDPAPATTFSHLDATTVLSRNIASLGIYPAVDPLDSTSKALSEDVVGKEHYEVARKVQEVLQRYKELQDIIAILGMDELSDEDKLTVSRARKIERFFSQPFSVAEQFTGMEGKYVPVKETIRGFREILEGKHDDIPEQAFLYVGTIEEAVAKSKDLAK

http://purl.uniprot.org/uniprot/Q8RGE2#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q8RGE2#attribution-43A9882434E9506AAFC23F741E3F28D4
manual: true
evidence: ECO_0000255
source: MF_01347

P29707
type: Protein
reviewed: true
created: 1993-04-01
modified: 2023-05-03
version: 128
mnemonic: ATPB_PROMO
citation: SIP67C1DDC3EA925F35
citation: http://purl.uniprot.org/citations/7556212
citation: http://purl.uniprot.org/citations/8422943
recommended name: SIP08BABEF77AC62493
alternative name: SIP65976A54C41B6B5E
enzyme: http://purl.uniprot.org/enzyme/7.2.2.1
organism: http://purl.uniprot.org/taxonomy/2333
annotation: SIP036F4BE870C7524A
annotation: SIPED981F3A358C523B
annotation: SIPA06120D6CC115C40
annotation: SIP8E162DAAE6BFEF86
annotation: SIP83FD62755ED5E545
annotation: SIP9082FABC15B8B634
annotation: PRO_0000144461
annotation: SIPD7C4815F2ED68D77
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/1003
classified with: http://purl.uniprot.org/keywords/139
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/739
classified with: http://purl.uniprot.org/keywords/1278
classified with: GO_0005886
classified with: GO_0045261
classified with: GO_0005524
classified with: GO_0046933
classified with: GO_0046932
classified with: GO_0046962
sequence: P29707-1

P29707-citation-SIP67C1DDC3EA925F35
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

DSM 2376 / Gra Succ2
type: Strain

P29707-citation-7556212
type: Citation Statement
scope: SEQUENCE REVISION

P29707-citation-8422943
type: Citation Statement
scope: PROTEIN SEQUENCE OF 1-7

SIP08BABEF77AC62493
type: Structured Name
full name: ATP synthase subunit beta, sodium ion specific
ec name: 7.2.2.1

SIP65976A54C41B6B5E
type: Structured Name
full name: Na(+)-translocating ATPase subunit beta

atpD
type: Gene
alternative label: uncD

SIP036F4BE870C7524A
type: Function Annotation
comment: Produces ATP from ADP in the presence of a sodium ion gradient across the membrane. The beta chain is the catalytic subunit.

SIPA06120D6CC115C40
type: Subunit Annotation
comment: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.

SIP83FD62755ED5E545
type: Annotation
comment: The ATPase of P.modestum is of special interest because it uses sodium ions instead of protons as the physiological coupling ion.

SIP9082FABC15B8B634
type: Similarity Annotation
comment: Belongs to the ATPase alpha/beta chains family.

PRO_0000144461
type: Chain Annotation
comment: ATP synthase subunit beta, sodium ion specific
mass: 50850
range: 22573219457283886tt1tt467

22573219457283886tt1
type: Position
type: ExactPosition
position: 1
reference: P29707-1

22573219457283886tt467
type: Position
type: ExactPosition
position: 467
reference: P29707-1

22573219457283886tt151
type: Position
type: ExactPosition
position: 151
reference: P29707-1

22573219457283886tt158
type: Position
type: ExactPosition
position: 158
reference: P29707-1

P29707-1
type: Simple Sequence
modified: 1996-02-01
version: 2
mass: 50850
value: MENKGVITQIIGPVVDVTFENELPRIYNALKIDRGNGEYLVAEVQQHLGNSVVRAVAMDATDGLQRGMEVVDTGPAITVPVGKAVLGRILNVLGEPVDEAGEVKAEEYAPIHREAPAFEDQGTEKEVFETGIKVVDLLAPYVKGGKIGLFGGAGVGKTVLIMELINNIAQGHGGLSVFAGVGERTREGRDLYDEMLESGVLDKTSLVYGQMNEPPGARLRVGLTGLTMAENFRDKEGQDVLFFVDNIFRFTQAPSEVSALLGRMPSAVGYQPNLATDMGALQERITSTKTGSITSVQAVYVPADDLTDPAPATTFTHLDATTVLSRRIASLGIYPAVDPLDSTSTALEPQIIGHEHYNTAREVQQILQRYKELQDIIAILGMDELSDEDKVTVNRARKIERFFSQPFHVAEQFTGMDGKYVTVKETIRGFKEIIEGKHDDLPEQAFLYVGTIDEAIAKARELMKGAE

http://purl.uniprot.org/uniprot/P29707#attribution-43A9882434E9506AAFC23F741E3F28D4
manual: true
evidence: ECO_0000255
source: MF_01347

Q8RGD9
type: Protein
reviewed: true
created: 2009-07-28
modified: 2023-02-22
version: 105
mnemonic: ATPD_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIPBD1370672D799AB1
alternative name: SIP998F9CFFBC003414
alternative name: SIP3196E599EDF744CD
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIP399C195B15BBCE9C
annotation: SIP7634A92669AFFCBE
annotation: SIPC55B538791817ADE
annotation: SIP53246498C75FE315
annotation: SIPAF26A3B29CFA9E8F
annotation: PRO_1000184721
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/997
classified with: http://purl.uniprot.org/keywords/139
classified with: http://purl.uniprot.org/keywords/375
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005886
classified with: GO_0045261
classified with: GO_0046933
classified with: GO_0015986
sequence: MIKSQVGRRYSKAIFEIAEEKKQVKEIYEMLNSAMVLYRTDKEFKHFILNPLIDNEQKKSVLNEIFGKDNSENLNILLYILDKGRMNCIKYIVAEYLKIYYRKNRILDVKATFTKELTDEQKKKLIDKLSQKTGKEINLEIKIDKDILGGGIIKIGDKIIDGSIRRELDNWRKS
proteome: Chromosome

Q8RGD9-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

Q8RGD9
type: Resource
database: IntAct
comment: 1

COG0712
type: Resource
database: eggNOG
comment: Bacteria

http://purl.uniprot.org/gene3d/1.10.520.20
type: Resource
database: Gene3D
comment: N-terminal domain of the delta subunit of the F1F0-ATP synthase
signature sequence match: Gene3D 1.10.520.20 match 1

MF_01416
type: Resource
database: HAMAP
comment: ATP_synth_delta_bact
signature sequence match: HAMAP MF 01416 match 1

IPR026015
type: Resource
database: InterPro
comment: ATP_synth_OSCP/delta_N_sf

IPR020781
type: Resource
database: InterPro
comment: ATPase_OSCP/d_CS

IPR000711
type: Resource
database: InterPro
comment: ATPase_OSCP/dsu

PTHR11910
type: Resource
database: PANTHER
comment: ATP SYNTHASE DELTA CHAIN
signature sequence match: PANTHER PTHR11910 match 1

PTHR11910:SF22
type: Resource
database: PANTHER
comment: ATP SYNTHASE SUBUNIT DELTA, CHLOROPLASTIC
signature sequence match: PANTHER PTHR11910:SF22 match 1

PF00213
type: Resource
database: Pfam
comment: OSCP
signature sequence match: Pfam PF00213 match 1

PR00125
type: Resource
database: PRINTS
comment: ATPASEDELTA

SSF47928
type: Resource
database: SUPFAM
comment: N-terminal domain of the delta subunit of the F1F0-ATP synthase
signature sequence match: SUPFAM SSF47928 match 1

TIGR01145
type: Resource
database: TIGRFAMs
comment: ATP_synt_delta
signature sequence match: TIGRFAMs TIGR01145 match 1

PS00389
type: Resource
database: PROSITE
comment: ATPASE_DELTA
signature sequence match: PROSITE PS00389 match 1

SIPBD1370672D799AB1
type: Structured Name
full name: ATP synthase subunit delta

SIP998F9CFFBC003414
type: Structured Name
full name: ATP synthase F(1) sector subunit delta

SIP3196E599EDF744CD
type: Structured Name
full name: F-type ATPase subunit delta
short name: F-ATPase subunit delta

atpH
type: Gene
locus name: FN0361

SIP399C195B15BBCE9C
type: Function Annotation
comment: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.

SIP7634A92669AFFCBE
type: Function Annotation
comment: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

SIPC55B538791817ADE
type: Subunit Annotation
comment: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.

SIPAF26A3B29CFA9E8F
type: Similarity Annotation
comment: Belongs to the ATPase delta chain family.

PRO_1000184721
type: Chain Annotation
comment: ATP synthase subunit delta
mass: 20493
range: 22861399147690286tt1tt174

22861399147690286tt1
type: Position
type: ExactPosition
position: 1
reference: MIKSQVGRRYSKAIFEIAEEKKQVKEIYEMLNSAMVLYRTDKEFKHFILNPLIDNEQKKSVLNEIFGKDNSENLNILLYILDKGRMNCIKYIVAEYLKIYYRKNRILDVKATFTKELTDEQKKKLIDKLSQKTGKEINLEIKIDKDILGGGIIKIGDKIIDGSIRRELDNWRKS

22861399147690286tt174
type: Position
type: ExactPosition
position: 174
reference: MIKSQVGRRYSKAIFEIAEEKKQVKEIYEMLNSAMVLYRTDKEFKHFILNPLIDNEQKKSVLNEIFGKDNSENLNILLYILDKGRMNCIKYIVAEYLKIYYRKNRILDVKATFTKELTDEQKKKLIDKLSQKTGKEINLEIKIDKDILGGGIIKIGDKIIDGSIRRELDNWRKS

MIKSQVGRRYSKAIFEIAEEKKQVKEIYEMLNSAMVLYRTDKEFKHFILNPLIDNEQKKSVLNEIFGKDNSENLNILLYILDKGRMNCIKYIVAEYLKIYYRKNRILDVKATFTKELTDEQKKKLIDKLSQKTGKEINLEIKIDKDILGGGIIKIGDKIIDGSIRRELDNWRKS
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 20493

http://purl.uniprot.org/uniprot/Q8RGD9#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q8RGD9#attribution-B1DD1792DF5CD88DBD7981631B7C9A70
manual: true
evidence: ECO_0000255
source: MF_01416

Q8KRV1
type: Protein
reviewed: true
created: 2009-05-05
modified: 2023-02-22
version: 67
mnemonic: ATPD_ILYTA
citation: http://purl.uniprot.org/citations/12531483
recommended name: SIPACBB02BFF6A1B358
alternative name: SIP998F9CFFBC003414
alternative name: SIP3196E599EDF744CD
organism: http://purl.uniprot.org/taxonomy/167644
annotation: SIPE870EE49CEC42E36
annotation: SIP6E8F12F8E17DDBF8
annotation: SIPA1C47B2D0421C92A
annotation: SIP05AC27929218973B
annotation: SIPB5653F2BB38C9ADD
annotation: SIP817858F313BE6BF2
annotation: PRO_0000371001
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/997
classified with: http://purl.uniprot.org/keywords/139
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/375
classified with: http://purl.uniprot.org/keywords/739
classified with: GO_0005886
classified with: GO_0045261
classified with: GO_0046933
classified with: GO_0006814
sequence: MIEAQVGKRYAEAIYGIAEANNKVKELYDSLNIVMELYKGDKEFKNLVDHPLVKKEEKKEFINKVFSEFEKFSLDILCYLVEKNRLSYIRGVVAEYLKIYYTKNRIVDVEATFAIEPSEKQKAKLIEKLEKKTGKKVNLVIKINKAIIAGGIIKIGDEIIDGSVRRQLDTVARG

Q8KRV1-citation-12531483
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: PROTEIN SEQUENCE OF 1-30

ATCC 35898 / DSM 2382
type: Strain

SIPACBB02BFF6A1B358
type: Structured Name
full name: ATP synthase subunit delta, sodium ion specific

SIP998F9CFFBC003414
type: Structured Name
full name: ATP synthase F(1) sector subunit delta

SIP3196E599EDF744CD
type: Structured Name
full name: F-type ATPase subunit delta
short name: F-ATPase subunit delta

atpH
type: Gene

SIPE870EE49CEC42E36
type: Function Annotation
comment: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.

SIP6E8F12F8E17DDBF8
type: Function Annotation
comment: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

SIPA1C47B2D0421C92A
type: Subunit Annotation
comment: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.

SIPB5653F2BB38C9ADD
type: Annotation
comment: The ATPase of I.tartaricus is of special interest because it uses sodium ions instead of protons as the physiological coupling ion.

SIP817858F313BE6BF2
type: Similarity Annotation
comment: Belongs to the ATPase delta chain family.

PRO_0000371001
type: Chain Annotation
comment: ATP synthase subunit delta, sodium ion specific
mass: 19962
range: 22861369268646190tt1tt174

22861369268646190tt1
type: Position
type: ExactPosition
position: 1
reference: MIEAQVGKRYAEAIYGIAEANNKVKELYDSLNIVMELYKGDKEFKNLVDHPLVKKEEKKEFINKVFSEFEKFSLDILCYLVEKNRLSYIRGVVAEYLKIYYTKNRIVDVEATFAIEPSEKQKAKLIEKLEKKTGKKVNLVIKINKAIIAGGIIKIGDEIIDGSVRRQLDTVARG

22861369268646190tt174
type: Position
type: ExactPosition
position: 174
reference: MIEAQVGKRYAEAIYGIAEANNKVKELYDSLNIVMELYKGDKEFKNLVDHPLVKKEEKKEFINKVFSEFEKFSLDILCYLVEKNRLSYIRGVVAEYLKIYYTKNRIVDVEATFAIEPSEKQKAKLIEKLEKKTGKKVNLVIKINKAIIAGGIIKIGDEIIDGSVRRQLDTVARG

MIEAQVGKRYAEAIYGIAEANNKVKELYDSLNIVMELYKGDKEFKNLVDHPLVKKEEKKEFINKVFSEFEKFSLDILCYLVEKNRLSYIRGVVAEYLKIYYTKNRIVDVEATFAIEPSEKQKAKLIEKLEKKTGKKVNLVIKINKAIIAGGIIKIGDEIIDGSVRRQLDTVARG
type: Simple Sequence
modified: 2002-10-01
version: 1
mass: 19962

http://purl.uniprot.org/uniprot/Q8KRV1#attribution-B1DD1792DF5CD88DBD7981631B7C9A70
manual: true
evidence: ECO_0000255
source: MF_01416

P29708
type: Protein
reviewed: true
created: 1993-04-01
modified: 2023-02-22
version: 99
mnemonic: ATPD_PROMO
citation: http://purl.uniprot.org/citations/1533602
citation: http://purl.uniprot.org/citations/1386022
citation: http://purl.uniprot.org/citations/8422943
conflicting sequence: SIP3FC122B80AA4B119
recommended name: SIPACBB02BFF6A1B358
alternative name: SIP998F9CFFBC003414
alternative name: SIP3196E599EDF744CD
organism: http://purl.uniprot.org/taxonomy/2333
annotation: SIP9A07290439AECB73
annotation: SIPFA91A5D3DF72910C
annotation: SIPBDECBC4573C14C6C
annotation: SIP55CF4B120FF1DA0D
annotation: SIPB90C2B159C085D02
annotation: SIPB00C06454F37CA89
annotation: PRO_0000193474
annotation: SIP47515533C5F82C6A
annotation: SIPE2DACDCB66A971D8
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/997
classified with: http://purl.uniprot.org/keywords/139
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/375
classified with: http://purl.uniprot.org/keywords/739
classified with: GO_0005886
classified with: GO_0045261
classified with: GO_0046933
classified with: GO_0006814
sequence: MIEAQVGRRYAEAIYEIAESNDNVKELYETLNGVMELYNTDKEFKTLVDHPLIKREDKKEFAKKIFGELEESSLNIIFYLIEKDRLSSIRGIVAEYLKIYYAKNQILDVEAIFAIEPTKDQKAKLIEQLEKKTGKKVNLEVSIDKSIIAGGIIKIGDEIIDGSVRRQLDTIARS

P29708-citation-1533602
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

DSM 2376 / Gra Succ2
type: Strain

P29708-citation-1386022
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-118

P29708-citation-8422943
type: Citation Statement
scope: PROTEIN SEQUENCE OF 1-7

SIPACBB02BFF6A1B358
type: Structured Name
full name: ATP synthase subunit delta, sodium ion specific

SIP998F9CFFBC003414
type: Structured Name
full name: ATP synthase F(1) sector subunit delta

SIP3196E599EDF744CD
type: Structured Name
full name: F-type ATPase subunit delta
short name: F-ATPase subunit delta

atpH
type: Gene
alternative label: uncH

SIP9A07290439AECB73
type: Function Annotation
comment: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.

SIPFA91A5D3DF72910C
type: Function Annotation
comment: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

SIPBDECBC4573C14C6C
type: Subunit Annotation
comment: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.

SIPB90C2B159C085D02
type: Annotation
comment: The ATPase of P.modestum is of special interest because it uses sodium ions instead of protons as the physiological coupling ion.

SIPB00C06454F37CA89
type: Similarity Annotation
comment: Belongs to the ATPase delta chain family.

PRO_0000193474
type: Chain Annotation
comment: ATP synthase subunit delta, sodium ion specific
mass: 19945
range: 22573219457284142tt1tt174

22573219457284142tt1
type: Position
type: ExactPosition
position: 1
reference: MIEAQVGRRYAEAIYEIAESNDNVKELYETLNGVMELYNTDKEFKTLVDHPLIKREDKKEFAKKIFGELEESSLNIIFYLIEKDRLSSIRGIVAEYLKIYYAKNQILDVEAIFAIEPTKDQKAKLIEQLEKKTGKKVNLEVSIDKSIIAGGIIKIGDEIIDGSVRRQLDTIARS

22573219457284142tt174
type: Position
type: ExactPosition
position: 174
reference: MIEAQVGRRYAEAIYEIAESNDNVKELYETLNGVMELYNTDKEFKTLVDHPLIKREDKKEFAKKIFGELEESSLNIIFYLIEKDRLSSIRGIVAEYLKIYYAKNQILDVEAIFAIEPTKDQKAKLIEQLEKKTGKKVNLEVSIDKSIIAGGIIKIGDEIIDGSVRRQLDTIARS

SIP47515533C5F82C6A
type: Sequence Conflict Annotation
conflicting sequence: SIP3FC122B80AA4B119
substitution: FF
range: 22573219457284142tt58tt59

22573219457284142tt58
type: Position
type: ExactPosition
position: 58
reference: MIEAQVGRRYAEAIYEIAESNDNVKELYETLNGVMELYNTDKEFKTLVDHPLIKREDKKEFAKKIFGELEESSLNIIFYLIEKDRLSSIRGIVAEYLKIYYAKNQILDVEAIFAIEPTKDQKAKLIEQLEKKTGKKVNLEVSIDKSIIAGGIIKIGDEIIDGSVRRQLDTIARS

22573219457284142tt59
type: Position
type: ExactPosition
position: 59
reference: MIEAQVGRRYAEAIYEIAESNDNVKELYETLNGVMELYNTDKEFKTLVDHPLIKREDKKEFAKKIFGELEESSLNIIFYLIEKDRLSSIRGIVAEYLKIYYAKNQILDVEAIFAIEPTKDQKAKLIEQLEKKTGKKVNLEVSIDKSIIAGGIIKIGDEIIDGSVRRQLDTIARS

SIPE2DACDCB66A971D8
type: Sequence Conflict Annotation
conflicting sequence: SIP3FC122B80AA4B119
substitution: LRMNL
range: 22573219457284142tt113tt117

22573219457284142tt113
type: Position
type: ExactPosition
position: 113
reference: MIEAQVGRRYAEAIYEIAESNDNVKELYETLNGVMELYNTDKEFKTLVDHPLIKREDKKEFAKKIFGELEESSLNIIFYLIEKDRLSSIRGIVAEYLKIYYAKNQILDVEAIFAIEPTKDQKAKLIEQLEKKTGKKVNLEVSIDKSIIAGGIIKIGDEIIDGSVRRQLDTIARS

22573219457284142tt117
type: Position
type: ExactPosition
position: 117
reference: MIEAQVGRRYAEAIYEIAESNDNVKELYETLNGVMELYNTDKEFKTLVDHPLIKREDKKEFAKKIFGELEESSLNIIFYLIEKDRLSSIRGIVAEYLKIYYAKNQILDVEAIFAIEPTKDQKAKLIEQLEKKTGKKVNLEVSIDKSIIAGGIIKIGDEIIDGSVRRQLDTIARS

MIEAQVGRRYAEAIYEIAESNDNVKELYETLNGVMELYNTDKEFKTLVDHPLIKREDKKEFAKKIFGELEESSLNIIFYLIEKDRLSSIRGIVAEYLKIYYAKNQILDVEAIFAIEPTKDQKAKLIEQLEKKTGKKVNLEVSIDKSIIAGGIIKIGDEIIDGSVRRQLDTIARS
type: Simple Sequence
modified: 1993-04-01
version: 1
mass: 19945

http://purl.uniprot.org/uniprot/P29708#attribution-B1DD1792DF5CD88DBD7981631B7C9A70
manual: true
evidence: ECO_0000255
source: MF_01416

http://purl.uniprot.org/uniprot/P29708#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

Q8RGE3
type: Protein
reviewed: true
created: 2002-08-02
modified: 2023-02-22
version: 115
mnemonic: ATPE_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIP45B225C96B5B8720
alternative name: SIP1A3B8E10330D1A15
alternative name: SIPA309F3952E20E34C
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIPAAA29C8AF4D20BFE
annotation: SIP1F3E41CFB8FA1CC0
annotation: SIP63F68A9744DAB366
annotation: SIP543D7AF61BC736F1
annotation: PRO_0000188138
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/997
classified with: http://purl.uniprot.org/keywords/139
classified with: http://purl.uniprot.org/keywords/375
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005886
classified with: GO_0045261
classified with: GO_0005524
classified with: GO_0046933
classified with: GO_0015986
sequence: MPSFDVSVVTQVKKILEQEAGYLRLRTSEGDIGILPNHAPFVAELSMGKMEIESPNKDRRDIYFLSGGFLEISDNQATVIADEVFPIEKIDVESEQALVENLKKELEKVSTEEEKRKLQKKIKISLAKIDAKNN
proteome: Chromosome

Q8RGE3-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

PDB 6Q45 tt1tt134
chain: H/P=1-134

COG0355
type: Resource
database: eggNOG
comment: Bacteria

cd12152
type: Resource
database: CDD
comment: F1-ATPase_delta
signature sequence match: CDD cd12152 match 1

http://purl.uniprot.org/gene3d/2.60.15.10
type: Resource
database: Gene3D
comment: F0F1 ATP synthase delta/epsilon subunit, N-terminal
signature sequence match: Gene3D 2.60.15.10 match 1

MF_00530
type: Resource
database: HAMAP
comment: ATP_synth_epsil_bac
signature sequence match: HAMAP MF 00530 match 1

IPR001469
type: Resource
database: InterPro
comment: ATP_synth_F1_dsu/esu

IPR020546
type: Resource
database: InterPro
comment: ATP_synth_F1_dsu/esu_N

IPR036771
type: Resource
database: InterPro
comment: ATPsynth_dsu/esu_N

PTHR13822
type: Resource
database: PANTHER
comment: ATP SYNTHASE DELTA/EPSILON CHAIN
signature sequence match: PANTHER PTHR13822 match 1

PTHR13822:SF7
type: Resource
database: PANTHER
comment: ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL
signature sequence match: PANTHER PTHR13822:SF7 match 1

PF02823
type: Resource
database: Pfam
comment: ATP-synt_DE_N
signature sequence match: Pfam PF02823 match 1

SSF51344
type: Resource
database: SUPFAM
comment: Epsilon subunit of F1F0-ATP synthase N-terminal domain
signature sequence match: SUPFAM SSF51344 match 1

TIGR01216
type: Resource
database: TIGRFAMs
comment: ATP_synt_epsi
signature sequence match: TIGRFAMs TIGR01216 match 1

SIP45B225C96B5B8720
type: Structured Name
full name: ATP synthase epsilon chain

SIP1A3B8E10330D1A15
type: Structured Name
full name: ATP synthase F1 sector epsilon subunit

SIPA309F3952E20E34C
type: Structured Name
full name: F-ATPase epsilon subunit

atpC
type: Gene
locus name: FN0357

SIPAAA29C8AF4D20BFE
type: Function Annotation
comment: Produces ATP from ADP in the presence of a proton gradient across the membrane.

SIP1F3E41CFB8FA1CC0
type: Subunit Annotation
comment: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.

SIP543D7AF61BC736F1
type: Similarity Annotation
comment: Belongs to the ATPase epsilon chain family.

PRO_0000188138
type: Chain Annotation
comment: ATP synthase epsilon chain
mass: 15134
range: 22861399147754286tt1tt134

22861399147754286tt1
type: Position
type: ExactPosition
position: 1
reference: MPSFDVSVVTQVKKILEQEAGYLRLRTSEGDIGILPNHAPFVAELSMGKMEIESPNKDRRDIYFLSGGFLEISDNQATVIADEVFPIEKIDVESEQALVENLKKELEKVSTEEEKRKLQKKIKISLAKIDAKNN

22861399147754286tt134
type: Position
type: ExactPosition
position: 134
reference: MPSFDVSVVTQVKKILEQEAGYLRLRTSEGDIGILPNHAPFVAELSMGKMEIESPNKDRRDIYFLSGGFLEISDNQATVIADEVFPIEKIDVESEQALVENLKKELEKVSTEEEKRKLQKKIKISLAKIDAKNN

MPSFDVSVVTQVKKILEQEAGYLRLRTSEGDIGILPNHAPFVAELSMGKMEIESPNKDRRDIYFLSGGFLEISDNQATVIADEVFPIEKIDVESEQALVENLKKELEKVSTEEEKRKLQKKIKISLAKIDAKNN
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 15134

http://purl.uniprot.org/uniprot/Q8RGE3#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q8RGE3#attribution-010E2FDA382798F3C5F7883FA248BBDD
manual: true
evidence: ECO_0000255
source: MF_00530

P29709
type: Protein
reviewed: true
created: 1993-04-01
modified: 2023-02-22
version: 112
mnemonic: ATPE_PROMO
citation: http://purl.uniprot.org/citations/1533602
citation: http://purl.uniprot.org/citations/8422943
recommended name: SIP31F4E35F08D0C6DE
alternative name: SIPB0896300CBC02C57
alternative name: SIPB6203C5BB44F59EB
organism: http://purl.uniprot.org/taxonomy/2333
annotation: SIPC2CA9F7ADD6D7F9D
annotation: SIP0B68ABFA292B5B98
annotation: SIP5609B87606913592
annotation: SIPC2264F737C2C3897
annotation: SIP596198092FAA9DFE
annotation: SIP91F68A272722A316
annotation: PRO_0000188178
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/997
classified with: http://purl.uniprot.org/keywords/139
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/739
classified with: GO_0005886
classified with: GO_0045261
classified with: GO_0005524
classified with: GO_0046933
classified with: GO_0006814
sequence: MATFKLEVVTPLKKVLDRDAEMVIMRTIEGDMGVMADHAPFVAELAVGEMKIKSANGEEAYFVSGGFLEISKEKTMILADEAIDVKEIDVERAKREAEIAKETLVKLKEDKDIAVTQKSLQEALTKVRIAEQYMHHL

P29709-citation-1533602
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

DSM 2376 / Gra Succ2
type: Strain

P29709-citation-8422943
type: Citation Statement
scope: PROTEIN SEQUENCE OF 2-8

SIP31F4E35F08D0C6DE
type: Structured Name
full name: ATP synthase epsilon chain, sodium ion specific

SIPB0896300CBC02C57
type: Structured Name
full name: F-ATPase epsilon subunit, sodium ion specific

SIPB6203C5BB44F59EB
type: Structured Name
full name: Na(+)-translocating ATPase subunit epsilon

atpC
type: Gene
alternative label: uncC

SIPC2CA9F7ADD6D7F9D
type: Function Annotation
comment: Produces ATP from ADP in the presence of a sodium gradient across the membrane.

SIP0B68ABFA292B5B98
type: Subunit Annotation
comment: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.

SIPC2264F737C2C3897
type: Annotation
comment: The ATPase of P.modestum is of special interest because it uses sodium ions instead of protons as the physiological coupling ion.

SIP596198092FAA9DFE
type: Similarity Annotation
comment: Belongs to the ATPase epsilon chain family.

SIP91F68A272722A316
type: Initiator Methionine Annotation
comment: Removed
range: 22573219457284398tt1tt1

22573219457284398tt1
type: Position
type: ExactPosition
position: 1
reference: MATFKLEVVTPLKKVLDRDAEMVIMRTIEGDMGVMADHAPFVAELAVGEMKIKSANGEEAYFVSGGFLEISKEKTMILADEAIDVKEIDVERAKREAEIAKETLVKLKEDKDIAVTQKSLQEALTKVRIAEQYMHHL

PRO_0000188178
type: Chain Annotation
comment: ATP synthase epsilon chain, sodium ion specific
mass: 15220
range: 22573219457284398tt2tt137

22573219457284398tt2
type: Position
type: ExactPosition
position: 2
reference: MATFKLEVVTPLKKVLDRDAEMVIMRTIEGDMGVMADHAPFVAELAVGEMKIKSANGEEAYFVSGGFLEISKEKTMILADEAIDVKEIDVERAKREAEIAKETLVKLKEDKDIAVTQKSLQEALTKVRIAEQYMHHL

22573219457284398tt137
type: Position
type: ExactPosition
position: 137
reference: MATFKLEVVTPLKKVLDRDAEMVIMRTIEGDMGVMADHAPFVAELAVGEMKIKSANGEEAYFVSGGFLEISKEKTMILADEAIDVKEIDVERAKREAEIAKETLVKLKEDKDIAVTQKSLQEALTKVRIAEQYMHHL

MATFKLEVVTPLKKVLDRDAEMVIMRTIEGDMGVMADHAPFVAELAVGEMKIKSANGEEAYFVSGGFLEISKEKTMILADEAIDVKEIDVERAKREAEIAKETLVKLKEDKDIAVTQKSLQEALTKVRIAEQYMHHL
type: Simple Sequence
modified: 2007-01-23
version: 2
mass: 15351

http://purl.uniprot.org/uniprot/P29709#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/P29709#attribution-8345C202821086AFEFC0149F296F8403
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/8422943

http://purl.uniprot.org/uniprot/P29709#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

Q8RGD8
type: Protein
reviewed: true
created: 2009-04-14
modified: 2023-02-22
version: 108
mnemonic: ATPF_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIP9908B01B6DDF809F
alternative name: SIP2DA520AFF070A505
alternative name: SIP21033C35161E7941
alternative name: SIPAF55909EB1107504
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIP1974FE9C30C67157
annotation: SIP56B2909B2EA9EBA3
annotation: SIP8D46019584B08A61
annotation: SIPAAA1E287B27C2CA4
annotation: SIP0C3921DCB9CFD54A
annotation: PRO_0000368499
annotation: SIPC3AF975E29B92CB3
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/66
classified with: http://purl.uniprot.org/keywords/997
classified with: http://purl.uniprot.org/keywords/138
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0005886
classified with: GO_0045263
classified with: GO_0046933
sequence: MPIISIDYTFFWQIINFFLLLFIVKKYFKEPISKIINERKQKIEAELVEATKNKKEAEQLLKDAEAQINASRKEATEIVKAAQRKAEEEAHNLIREARENRENILKTTELEITKIKNDAKEELGREVKNLAAELAEKIIKEKVDDAQEISLIDKFIAEVGEDK
proteome: Chromosome

Q8RGD8-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

Q8RGD8
type: Resource
database: IntAct
comment: 1

COG0711
type: Resource
database: eggNOG
comment: Bacteria

cd06503
type: Resource
database: CDD
comment: ATP-synt_Fo_b
signature sequence match: CDD cd06503 match 1

MF_01398
type: Resource
database: HAMAP
comment: ATP_synth_b_bprime
signature sequence match: HAMAP MF 01398 match 1

IPR002146
type: Resource
database: InterPro
comment: ATP_synth_b/b'su_bac/chlpt

IPR005864
type: Resource
database: InterPro
comment: ATP_synth_F0_bsu_bac

PTHR33445:SF1
type: Resource
database: PANTHER
comment: ATP SYNTHASE SUBUNIT B
signature sequence match: PANTHER PTHR33445:SF1 match 1

PTHR33445
type: Resource
database: PANTHER
comment: ATP SYNTHASE SUBUNIT B', CHLOROPLASTIC
signature sequence match: PANTHER PTHR33445 match 1

PF00430
type: Resource
database: Pfam
comment: ATP-synt_B
signature sequence match: Pfam PF00430 match 1

TIGR01144
type: Resource
database: TIGRFAMs
comment: ATP_synt_b
signature sequence match: TIGRFAMs TIGR01144 match 1

SIP9908B01B6DDF809F
type: Structured Name
full name: ATP synthase subunit b

SIP2DA520AFF070A505
type: Structured Name
full name: ATP synthase F(0) sector subunit b

SIP21033C35161E7941
type: Structured Name
full name: ATPase subunit I

SIPAF55909EB1107504
type: Structured Name
full name: F-type ATPase subunit b
short name: F-ATPase subunit b

atpF
type: Gene
locus name: FN0362

SIP1974FE9C30C67157
type: Function Annotation
comment: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.

SIP56B2909B2EA9EBA3
type: Function Annotation
comment: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).

SIP8D46019584B08A61
type: Subunit Annotation
comment: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.

SIP0C3921DCB9CFD54A
type: Similarity Annotation
comment: Belongs to the ATPase B chain family.

PRO_0000368499
type: Chain Annotation
comment: ATP synthase subunit b
mass: 18943
range: 22861399147690030tt1tt163

22861399147690030tt1
type: Position
type: ExactPosition
position: 1
reference: MPIISIDYTFFWQIINFFLLLFIVKKYFKEPISKIINERKQKIEAELVEATKNKKEAEQLLKDAEAQINASRKEATEIVKAAQRKAEEEAHNLIREARENRENILKTTELEITKIKNDAKEELGREVKNLAAELAEKIIKEKVDDAQEISLIDKFIAEVGEDK

22861399147690030tt163
type: Position
type: ExactPosition
position: 163
reference: MPIISIDYTFFWQIINFFLLLFIVKKYFKEPISKIINERKQKIEAELVEATKNKKEAEQLLKDAEAQINASRKEATEIVKAAQRKAEEEAHNLIREARENRENILKTTELEITKIKNDAKEELGREVKNLAAELAEKIIKEKVDDAQEISLIDKFIAEVGEDK

SIPC3AF975E29B92CB3
type: Transmembrane Annotation
comment: Helical
range: 22861399147690030tt3tt23

22861399147690030tt3
type: Position
type: ExactPosition
position: 3
reference: MPIISIDYTFFWQIINFFLLLFIVKKYFKEPISKIINERKQKIEAELVEATKNKKEAEQLLKDAEAQINASRKEATEIVKAAQRKAEEEAHNLIREARENRENILKTTELEITKIKNDAKEELGREVKNLAAELAEKIIKEKVDDAQEISLIDKFIAEVGEDK

22861399147690030tt23
type: Position
type: ExactPosition
position: 23
reference: MPIISIDYTFFWQIINFFLLLFIVKKYFKEPISKIINERKQKIEAELVEATKNKKEAEQLLKDAEAQINASRKEATEIVKAAQRKAEEEAHNLIREARENRENILKTTELEITKIKNDAKEELGREVKNLAAELAEKIIKEKVDDAQEISLIDKFIAEVGEDK

MPIISIDYTFFWQIINFFLLLFIVKKYFKEPISKIINERKQKIEAELVEATKNKKEAEQLLKDAEAQINASRKEATEIVKAAQRKAEEEAHNLIREARENRENILKTTELEITKIKNDAKEELGREVKNLAAELAEKIIKEKVDDAQEISLIDKFIAEVGEDK
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 18943

http://purl.uniprot.org/uniprot/Q8RGD8#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q8RGD8#attribution-F532F36C147A4DB2E74653A5DA543EB9
manual: true
evidence: ECO_0000255
source: MF_01398

Q8KRV2
type: Protein
reviewed: true
created: 2009-04-14
modified: 2023-02-22
version: 70
mnemonic: ATPF_ILYTA
citation: http://purl.uniprot.org/citations/12531483
conflicting sequence: SIP25C111F6DB75DE3D
recommended name: SIP0653E50A8106CAE6
alternative name: SIP2DA520AFF070A505
alternative name: SIP21033C35161E7941
alternative name: SIPAF55909EB1107504
organism: http://purl.uniprot.org/taxonomy/167644
annotation: SIP2790F53C322F8000
annotation: SIPF03B5C6AF2287135
annotation: SIP43468D0C1204B12A
annotation: SIP8A51E89F2424A551
annotation: SIP88F60255BA0E5D7A
annotation: SIPF7E5B83F43E99A51
annotation: PRO_0000368530
annotation: SIPD8FEE2D5B10B50BD
annotation: SIP2266A6AF0C0A4E08
annotation: SIP897CA6369C6B247D
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/66
classified with: http://purl.uniprot.org/keywords/997
classified with: http://purl.uniprot.org/keywords/138
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/739
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0005886
classified with: GO_0045263
classified with: GO_0046933
classified with: GO_0006814
sequence: MAPQNMPAVSIDINMFWQIINFLILMFFFKKYFQKPISKVLDARKEKIANELKQAEIDREMAAKANEETQGILKAARTEANEILLRAEKKADDRKEAILKEANSQREKTIKSAELEVEKMKKQARKELQSEVTALAVNLAEKMINEKLDSKLGANLLNVLLKR

Q8KRV2-citation-12531483
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: PROTEIN SEQUENCE OF 1-29

ATCC 35898 / DSM 2382
type: Strain

IPR028987
type: Resource
database: InterPro
comment: ATP_synth_B-like_membr_sf

SSF81573
type: Resource
database: SUPFAM
comment: F1F0 ATP synthase subunit B, membrane domain
signature sequence match: SUPFAM SSF81573 match 1

SIP25C111F6DB75DE3D
type: External Sequence
comment: AA sequence
citation: http://purl.uniprot.org/citations/12531483

SIP0653E50A8106CAE6
type: Structured Name
full name: ATP synthase subunit b, sodium ion specific

SIP2DA520AFF070A505
type: Structured Name
full name: ATP synthase F(0) sector subunit b

SIP21033C35161E7941
type: Structured Name
full name: ATPase subunit I

SIPAF55909EB1107504
type: Structured Name
full name: F-type ATPase subunit b
short name: F-ATPase subunit b

atpF
type: Gene

SIP2790F53C322F8000
type: Function Annotation
comment: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity).

SIPF03B5C6AF2287135
type: Function Annotation
comment: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).

SIP43468D0C1204B12A
type: Subunit Annotation
comment: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains (By similarity).

SIP88F60255BA0E5D7A
type: Annotation
comment: The ATPase of I.tartaricus is of special interest because it uses sodium ions instead of protons as the physiological coupling ion.

SIPF7E5B83F43E99A51
type: Similarity Annotation
comment: Belongs to the ATPase B chain family.

PRO_0000368530
type: Chain Annotation
comment: ATP synthase subunit b, sodium ion specific
mass: 18718
range: 22861369268646446tt1tt163

22861369268646446tt1
type: Position
type: ExactPosition
position: 1
reference: MAPQNMPAVSIDINMFWQIINFLILMFFFKKYFQKPISKVLDARKEKIANELKQAEIDREMAAKANEETQGILKAARTEANEILLRAEKKADDRKEAILKEANSQREKTIKSAELEVEKMKKQARKELQSEVTALAVNLAEKMINEKLDSKLGANLLNVLLKR

22861369268646446tt163
type: Position
type: ExactPosition
position: 163
reference: MAPQNMPAVSIDINMFWQIINFLILMFFFKKYFQKPISKVLDARKEKIANELKQAEIDREMAAKANEETQGILKAARTEANEILLRAEKKADDRKEAILKEANSQREKTIKSAELEVEKMKKQARKELQSEVTALAVNLAEKMINEKLDSKLGANLLNVLLKR

SIPD8FEE2D5B10B50BD
type: Transmembrane Annotation
comment: Helical
range: 22861369268646446tt9tt29

22861369268646446tt9
type: Position
type: ExactPosition
position: 9
reference: MAPQNMPAVSIDINMFWQIINFLILMFFFKKYFQKPISKVLDARKEKIANELKQAEIDREMAAKANEETQGILKAARTEANEILLRAEKKADDRKEAILKEANSQREKTIKSAELEVEKMKKQARKELQSEVTALAVNLAEKMINEKLDSKLGANLLNVLLKR

22861369268646446tt29
type: Position
type: ExactPosition
position: 29
reference: MAPQNMPAVSIDINMFWQIINFLILMFFFKKYFQKPISKVLDARKEKIANELKQAEIDREMAAKANEETQGILKAARTEANEILLRAEKKADDRKEAILKEANSQREKTIKSAELEVEKMKKQARKELQSEVTALAVNLAEKMINEKLDSKLGANLLNVLLKR

SIP2266A6AF0C0A4E08
type: Sequence Conflict Annotation
conflicting sequence: SIP25C111F6DB75DE3D
substitution: I
range: 22861369268646446tt17tt17

22861369268646446tt17
type: Position
type: ExactPosition
position: 17
reference: MAPQNMPAVSIDINMFWQIINFLILMFFFKKYFQKPISKVLDARKEKIANELKQAEIDREMAAKANEETQGILKAARTEANEILLRAEKKADDRKEAILKEANSQREKTIKSAELEVEKMKKQARKELQSEVTALAVNLAEKMINEKLDSKLGANLLNVLLKR

22861369268646446tt21
type: Position
type: ExactPosition
position: 21
reference: MAPQNMPAVSIDINMFWQIINFLILMFFFKKYFQKPISKVLDARKEKIANELKQAEIDREMAAKANEETQGILKAARTEANEILLRAEKKADDRKEAILKEANSQREKTIKSAELEVEKMKKQARKELQSEVTALAVNLAEKMINEKLDSKLGANLLNVLLKR

MAPQNMPAVSIDINMFWQIINFLILMFFFKKYFQKPISKVLDARKEKIANELKQAEIDREMAAKANEETQGILKAARTEANEILLRAEKKADDRKEAILKEANSQREKTIKSAELEVEKMKKQARKELQSEVTALAVNLAEKMINEKLDSKLGANLLNVLLKR
type: Simple Sequence
modified: 2002-10-01
version: 1
mass: 18718

http://purl.uniprot.org/uniprot/Q8KRV2#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/Q8KRV2#attribution-DC036A124EC8E88DF072B29F6D9BB9FE
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/Q8KRV2#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

P21904
type: Protein
reviewed: true
created: 1991-05-01
modified: 2023-02-22
version: 106
mnemonic: ATPF_PROMO
old mnemonic: ATNB_PROMO
citation: http://purl.uniprot.org/citations/2174545
citation: http://purl.uniprot.org/citations/1386022
citation: http://purl.uniprot.org/citations/2170948
citation: http://purl.uniprot.org/citations/8422943
conflicting sequence: SIP54B34B3F989132AD
conflicting sequence: SIP6782FC61A8460F63
conflicting sequence: SIP2622F780E3D8ED9E
recommended name: SIP0653E50A8106CAE6
alternative name: SIP2DA520AFF070A505
alternative name: SIP21033C35161E7941
alternative name: SIPAF55909EB1107504
organism: http://purl.uniprot.org/taxonomy/2333
annotation: SIPD3684620A039A371
annotation: SIPCCA09EEC22E1F10B
annotation: SIP95854D70BCBB3BAF
annotation: SIP6F7102192D69188B
annotation: SIP1C905331433C808B
annotation: SIPA468D0A1041C3FFC
annotation: SIP674404FB1850AA72
annotation: SIP44448848704C7ADE
annotation: SIP4A8203F94B15D56D
annotation: PRO_0000082383
annotation: SIP0FF195B9D17AEB01
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/66
classified with: http://purl.uniprot.org/keywords/997
classified with: http://purl.uniprot.org/keywords/138
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/739
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0005886
classified with: GO_0045263
classified with: GO_0046933
classified with: GO_0006814
sequence: MAPQNMPAVSIDINMFWQIINFLILMFFFKKYFQKPIAKVLDARKEKIANDLKQAEIDKEMAAKANGEAQGIVKSAKTEANEMLLRAEKKADERKETILKEANTQREKMLKSAEVEIEKMKEQARKELQLEVTDLAVKLAEKMINEKVDAKIGANLLDQFIGEVGEEK

P21904-citation-2174545
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

DSM 2376 / Gra Succ2
type: Strain

P21904-citation-1386022
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

P21904-citation-2170948
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

P21904-citation-8422943
type: Citation Statement
scope: PROTEIN SEQUENCE OF 1-7

EMBL CAA38580.1
comment: Different initiation.

EMBL CAA46896.1
comment: Different initiation.

EMBL CAA41370.1
comment: Different initiation.

http://purl.uniprot.org/gene3d/1.20.5.620
type: Resource
database: Gene3D
comment: F1F0 ATP synthase subunit B, membrane domain
signature sequence match: Gene3D 1.20.5.620 match 1

SIP0653E50A8106CAE6
type: Structured Name
full name: ATP synthase subunit b, sodium ion specific

SIP2DA520AFF070A505
type: Structured Name
full name: ATP synthase F(0) sector subunit b

SIP21033C35161E7941
type: Structured Name
full name: ATPase subunit I

SIPAF55909EB1107504
type: Structured Name
full name: F-type ATPase subunit b
short name: F-ATPase subunit b

atpF
type: Gene
alternative label: uncF

SIPD3684620A039A371
type: Function Annotation
comment: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity).

SIPCCA09EEC22E1F10B
type: Function Annotation
comment: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).

SIP95854D70BCBB3BAF
type: Subunit Annotation
comment: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains (By similarity).

SIP1C905331433C808B
type: Annotation
comment: The ATPase of P.modestum is of special interest because it uses sodium ions instead of protons as the physiological coupling ion.

SIPA468D0A1041C3FFC
type: Similarity Annotation
comment: Belongs to the ATPase B chain family.

PRO_0000082383
type: Chain Annotation
comment: ATP synthase subunit b, sodium ion specific
mass: 19201
range: 22573185131099182tt1tt168

22573185131099182tt1
type: Position
type: ExactPosition
position: 1
reference: MAPQNMPAVSIDINMFWQIINFLILMFFFKKYFQKPIAKVLDARKEKIANDLKQAEIDKEMAAKANGEAQGIVKSAKTEANEMLLRAEKKADERKETILKEANTQREKMLKSAEVEIEKMKEQARKELQLEVTDLAVKLAEKMINEKVDAKIGANLLDQFIGEVGEEK

22573185131099182tt168
type: Position
type: ExactPosition
position: 168
reference: MAPQNMPAVSIDINMFWQIINFLILMFFFKKYFQKPIAKVLDARKEKIANDLKQAEIDKEMAAKANGEAQGIVKSAKTEANEMLLRAEKKADERKETILKEANTQREKMLKSAEVEIEKMKEQARKELQLEVTDLAVKLAEKMINEKVDAKIGANLLDQFIGEVGEEK

SIP0FF195B9D17AEB01
type: Transmembrane Annotation
comment: Helical
range: 22573185131099182tt9tt29

22573185131099182tt9
type: Position
type: ExactPosition
position: 9
reference: MAPQNMPAVSIDINMFWQIINFLILMFFFKKYFQKPIAKVLDARKEKIANDLKQAEIDKEMAAKANGEAQGIVKSAKTEANEMLLRAEKKADERKETILKEANTQREKMLKSAEVEIEKMKEQARKELQLEVTDLAVKLAEKMINEKVDAKIGANLLDQFIGEVGEEK

22573185131099182tt29
type: Position
type: ExactPosition
position: 29
reference: MAPQNMPAVSIDINMFWQIINFLILMFFFKKYFQKPIAKVLDARKEKIANDLKQAEIDKEMAAKANGEAQGIVKSAKTEANEMLLRAEKKADERKETILKEANTQREKMLKSAEVEIEKMKEQARKELQLEVTDLAVKLAEKMINEKVDAKIGANLLDQFIGEVGEEK

MAPQNMPAVSIDINMFWQIINFLILMFFFKKYFQKPIAKVLDARKEKIANDLKQAEIDKEMAAKANGEAQGIVKSAKTEANEMLLRAEKKADERKETILKEANTQREKMLKSAEVEIEKMKEQARKELQLEVTDLAVKLAEKMINEKVDAKIGANLLDQFIGEVGEEK
type: Simple Sequence
modified: 1993-04-01
version: 2
mass: 19201

http://purl.uniprot.org/uniprot/P21904#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/P21904#attribution-DC036A124EC8E88DF072B29F6D9BB9FE
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/P21904#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

Q8RGE1
type: Protein
reviewed: true
created: 2005-11-22
modified: 2023-02-22
version: 101
mnemonic: ATPG_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIPA74E809999CB5FD8
alternative name: SIP44F0DB08F4BB3CEB
alternative name: SIP4FE115C883A6523F
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIP07A8C94D5F0505D8
annotation: SIPADFDFE65595BDAA2
annotation: SIP9317FA2B4F80A34E
annotation: SIPDAB639C0DC9D4394
annotation: PRO_0000073286
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/997
classified with: http://purl.uniprot.org/keywords/139
classified with: http://purl.uniprot.org/keywords/375
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005886
classified with: GO_0045261
classified with: GO_0005524
classified with: GO_0046933
classified with: GO_0015986
classified with: GO_0042777
sequence: Q8RGE1-1
proteome: Chromosome

Q8RGE1-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

PDB 6Q45 tt1tt282
chain: G/O=1-282

Q8RGE1
type: Resource
database: IntAct
comment: 1

COG0224
type: Resource
database: eggNOG
comment: Bacteria

cd12151
type: Resource
database: CDD
comment: F1-ATPase_gamma
signature sequence match: CDD cd12151 match 1

http://purl.uniprot.org/gene3d/1.10.287.80
type: Resource
database: Gene3D
comment: ATP synthase, gamma subunit, helix hairpin domain
signature sequence match: Gene3D 1.10.287.80 match 1

MF_00815
type: Resource
database: HAMAP
comment: ATP_synth_gamma_bact
signature sequence match: HAMAP MF 00815 match 1

IPR035968
type: Resource
database: InterPro
comment: ATP_synth_F1_ATPase_gsu

IPR000131
type: Resource
database: InterPro
comment: ATP_synth_F1_gsu

IPR023632
type: Resource
database: InterPro
comment: ATP_synth_F1_gsu_CS

PTHR11693
type: Resource
database: PANTHER
comment: ATP SYNTHASE GAMMA CHAIN
signature sequence match: PANTHER PTHR11693 match 1

PTHR11693:SF41
type: Resource
database: PANTHER
comment: ATP SYNTHASE GAMMA CHAIN
signature sequence match: PANTHER PTHR11693:SF41 match 1

PF00231
type: Resource
database: Pfam
comment: ATP-synt
signature sequence match: Pfam PF00231 match 1

PR00126
type: Resource
database: PRINTS
comment: ATPASEGAMMA

SSF52943
type: Resource
database: SUPFAM
comment: ATP synthase (F1-ATPase), gamma subunit
signature sequence match: SUPFAM SSF52943 match 1

TIGR01146
type: Resource
database: TIGRFAMs
comment: ATPsyn_F1gamma
signature sequence match: TIGRFAMs TIGR01146 match 1

PS00153
type: Resource
database: PROSITE
comment: ATPASE_GAMMA
signature sequence match: PROSITE PS00153 match 1

SIPA74E809999CB5FD8
type: Structured Name
full name: ATP synthase gamma chain

SIP44F0DB08F4BB3CEB
type: Structured Name
full name: ATP synthase F1 sector gamma subunit

SIP4FE115C883A6523F
type: Structured Name
full name: F-ATPase gamma subunit

atpG
type: Gene
locus name: FN0359

SIP07A8C94D5F0505D8
type: Function Annotation
comment: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

SIPADFDFE65595BDAA2
type: Subunit Annotation
comment: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.

SIPDAB639C0DC9D4394
type: Similarity Annotation
comment: Belongs to the ATPase gamma chain family.

PRO_0000073286
type: Chain Annotation
comment: ATP synthase gamma chain
mass: 32132
range: 22861399147753774tt1tt282

22861399147753774tt1
type: Position
type: ExactPosition
position: 1
reference: Q8RGE1-1

22861399147753774tt282
type: Position
type: ExactPosition
position: 282
reference: Q8RGE1-1

Q8RGE1-1
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 32132
value: MPGMKEIKSRIKSVQSTRQITNAMEIVSTTKFKRYSKLVTESRPYEESMRKILGNIASGVKNEGHPLFDGRKEVKSIAIIVITSDRGLCGSFNSSTLKELEKLVEKNKNKNITIIPFGRKAIDFITKRNYEFSESFSKISPDEMNKIAGEISEEVVEKYNNHIYDEVYVIYNKFISALRYDLTCERIIPITRPEVELNSEYIFEPSTEYILSALLPRFINLQIYQAILNNTASEHSARKNSMSSATDNADEMIKTLNIKYNRNRQSAITQEITEIVGGASAL

http://purl.uniprot.org/uniprot/Q8RGE1#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q8RGE1#attribution-0FB3B03FF09B8F0EFB536369EB58B6C4
manual: true
evidence: ECO_0000255
source: MF_00815

P29710
type: Protein
reviewed: true
created: 1993-04-01
modified: 2023-02-22
version: 99
mnemonic: ATPG_PROMO
citation: http://purl.uniprot.org/citations/1533602
citation: http://purl.uniprot.org/citations/8422943
recommended name: SIP427BFC843BCDE4B4
alternative name: SIP6FAD49A87DB7D879
organism: http://purl.uniprot.org/taxonomy/2333
annotation: SIP70B7471533307713
annotation: SIPF6B0CC0208213CAE
annotation: SIP034EF97C57753695
annotation: SIPED28894BC6D20F38
annotation: SIP8AD6010309EFE21D
annotation: SIPB5AFB05E0467F3C3
annotation: PRO_0000073344
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/997
classified with: http://purl.uniprot.org/keywords/139
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/375
classified with: http://purl.uniprot.org/keywords/739
classified with: GO_0005886
classified with: GO_0045261
classified with: GO_0005524
classified with: GO_0046933
classified with: GO_0042777
classified with: GO_0006814
sequence: P29710-1

P29710-citation-1533602
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

DSM 2376 / Gra Succ2
type: Strain

P29710-citation-8422943
type: Citation Statement
scope: PROTEIN SEQUENCE OF 2-8

SIP427BFC843BCDE4B4
type: Structured Name
full name: ATP synthase gamma chain, sodium ion specific

SIP6FAD49A87DB7D879
type: Structured Name
full name: F-ATPase gamma subunit, sodium ion specific

atpG
type: Gene
alternative label: uncG

SIP70B7471533307713
type: Function Annotation
comment: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

SIPF6B0CC0208213CAE
type: Subunit Annotation
comment: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.

SIPED28894BC6D20F38
type: Annotation
comment: The ATPase of P.modestum is of special interest because it uses sodium ions instead of protons as the physiological coupling ion.

SIP8AD6010309EFE21D
type: Similarity Annotation
comment: Belongs to the ATPase gamma chain family.

SIPB5AFB05E0467F3C3
type: Initiator Methionine Annotation
comment: Removed
range: 22573219457347630tt1tt1

22573219457347630tt1
type: Position
type: ExactPosition
position: 1
reference: P29710-1

PRO_0000073344
type: Chain Annotation
comment: ATP synthase gamma chain, sodium ion specific
mass: 31681
range: 22573219457347630tt2tt282

22573219457347630tt2
type: Position
type: ExactPosition
position: 2
reference: P29710-1

22573219457347630tt282
type: Position
type: ExactPosition
position: 282
reference: P29710-1

P29710-1
type: Simple Sequence
modified: 2007-01-23
version: 2
mass: 31813
value: MAAGKEIKSRISSVQSTRQITKAMEIVSSTKFKKFQALVNQSKPYSGSMDKVLANLAAGIKNERHPLFDGKTEVKRIGIIVMTSDRGLCGGFNSSTLKEMEKLIVANPDKEVSVIAIGKKGRDYCKKKDRDLKAEYIQLIPETMFDKAKEISENIVEYFYEDIFDEVYLIYNEFISALSTELIVKKLLPIERIEVQDNTTYIFEPSVEDILSSLLPKYLNIQLYQAILENTASEHSARKNAMKNATDNAEDMIKDLTLQYNRERQAAITQEISEIVSGASAL

http://purl.uniprot.org/uniprot/P29710#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/P29710#attribution-8345C202821086AFEFC0149F296F8403
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/8422943

http://purl.uniprot.org/uniprot/P29710#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

Q8RGD7
type: Protein
reviewed: true
created: 2009-03-03
modified: 2023-02-22
version: 117
mnemonic: ATPL_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIP5FF7173628D234E4
alternative name: SIPB0BFD942ED335F81
alternative name: SIP36C9FA1BB6433AC0
alternative name: SIP47A478988503071F
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIPD3EB84422FF2B40E
annotation: SIP03E2C57DFF013DBE
annotation: SIPB5D0733D5A9524B9
annotation: SIPA03618C8490F336E
annotation: SIPF9298420CDFEEA6D
annotation: PRO_0000365883
annotation: SIP5E86E8B8C3D3EA38
annotation: SIP6E39530DF12DB0B3
annotation: SIP67365AB1F780B739
annotation: SIP57CEF1634751EA31
annotation: SIPD5FE06887E46314C
annotation: SIP9B5E862257F2AA10
annotation: SIP31FB47CECC4412CF
annotation: SIPC8A5B9454553BED1
annotation: SIPC888F98BE44C64C4
interaction: http://purl.uniprot.org/intact/16063254-16063254
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/66
classified with: http://purl.uniprot.org/keywords/997
classified with: http://purl.uniprot.org/keywords/138
classified with: http://purl.uniprot.org/keywords/446
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0005886
classified with: GO_0045263
classified with: GO_0042802
classified with: GO_0008289
classified with: GO_0046933
classified with: GO_0015986
sequence: MDLLTAKTIVLGCSAVGAGLAMIAGLGPGIGEGYAAGKAVESVARQPEARGSIISTMILGQAVAESTGIYSLVIALILLYANPFLSKLG
proteome: Chromosome

Q8RGD7-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

3ZK1
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.20
chain sequence mapping: PDB 3ZK1 tt1tt89

PDB 3ZK1 tt1tt89
chain: A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V=1-89

3ZK2
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.63
chain sequence mapping: PDB 3ZK2 tt1tt89

PDB 3ZK2 tt1tt89
chain: A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V=1-89

COG0636
type: Resource
database: eggNOG
comment: Bacteria

cd18184
type: Resource
database: CDD
comment: ATP-synt_Fo_c_NaATPase
signature sequence match: CDD cd18184 match 1

http://purl.uniprot.org/gene3d/1.20.120.610
type: Resource
database: Gene3D
comment: lithium bound rotor ring of v- atpase
signature sequence match: Gene3D 1.20.120.610 match 1

MF_01396
type: Resource
database: HAMAP
comment: ATP_synth_c_bact
signature sequence match: HAMAP MF 01396 match 1

IPR005953
type: Resource
database: InterPro
comment: ATP_synth_csu_bac/chlpt

IPR000454
type: Resource
database: InterPro
comment: ATP_synth_F0_csu

IPR020537
type: Resource
database: InterPro
comment: ATP_synth_F0_csu_DDCD_BS

IPR002379
type: Resource
database: InterPro
comment: ATPase_proteolipid_c-like_dom

IPR035921
type: Resource
database: InterPro
comment: F/V-ATP_Csub_sf

PTHR10031
type: Resource
database: PANTHER
comment: ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL
signature sequence match: PANTHER PTHR10031 match 1

PTHR10031:SF0
type: Resource
database: PANTHER
comment: ATPASE PROTEIN 9
signature sequence match: PANTHER PTHR10031:SF0 match 1

PF00137
type: Resource
database: Pfam
comment: ATP-synt_C
signature sequence match: Pfam PF00137 match 1

PR00124
type: Resource
database: PRINTS
comment: ATPASEC

SSF81333
type: Resource
database: SUPFAM
comment: F1F0 ATP synthase subunit C
signature sequence match: SUPFAM SSF81333 match 1

TIGR01260
type: Resource
database: TIGRFAMs
comment: ATP_synt_c
signature sequence match: TIGRFAMs TIGR01260 match 1

PS00605
type: Resource
database: PROSITE
comment: ATPASE_C
signature sequence match: PROSITE PS00605 match 1

SIP5FF7173628D234E4
type: Structured Name
full name: ATP synthase subunit c

SIPB0BFD942ED335F81
type: Structured Name
full name: ATP synthase F(0) sector subunit c

SIP36C9FA1BB6433AC0
type: Structured Name
full name: F-type ATPase subunit c
short name: F-ATPase subunit c

SIP47A478988503071F
type: Structured Name
full name: Lipid-binding protein

atpE
type: Gene
locus name: FN0363

SIPD3EB84422FF2B40E
type: Function Annotation
comment: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.

SIP03E2C57DFF013DBE
type: Function Annotation
comment: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.

SIPB5D0733D5A9524B9
type: Subunit Annotation
comment: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.

SIPF9298420CDFEEA6D
type: Similarity Annotation
comment: Belongs to the ATPase C chain family.

PRO_0000365883
type: Chain Annotation
comment: ATP synthase subunit c
mass: 8863
range: 22861399147689774tt1tt89

22861399147689774tt1
type: Position
type: ExactPosition
position: 1
reference: MDLLTAKTIVLGCSAVGAGLAMIAGLGPGIGEGYAAGKAVESVARQPEARGSIISTMILGQAVAESTGIYSLVIALILLYANPFLSKLG

22861399147689774tt89
type: Position
type: ExactPosition
position: 89
reference: MDLLTAKTIVLGCSAVGAGLAMIAGLGPGIGEGYAAGKAVESVARQPEARGSIISTMILGQAVAESTGIYSLVIALILLYANPFLSKLG

SIP5E86E8B8C3D3EA38
type: Transmembrane Annotation
comment: Helical
range: 22861399147689774tt9tt29

22861399147689774tt9
type: Position
type: ExactPosition
position: 9
reference: MDLLTAKTIVLGCSAVGAGLAMIAGLGPGIGEGYAAGKAVESVARQPEARGSIISTMILGQAVAESTGIYSLVIALILLYANPFLSKLG

22861399147689774tt29
type: Position
type: ExactPosition
position: 29
reference: MDLLTAKTIVLGCSAVGAGLAMIAGLGPGIGEGYAAGKAVESVARQPEARGSIISTMILGQAVAESTGIYSLVIALILLYANPFLSKLG

SIP6E39530DF12DB0B3
type: Transmembrane Annotation
comment: Helical
range: 22861399147689774tt58tt78

22861399147689774tt58
type: Position
type: ExactPosition
position: 58
reference: MDLLTAKTIVLGCSAVGAGLAMIAGLGPGIGEGYAAGKAVESVARQPEARGSIISTMILGQAVAESTGIYSLVIALILLYANPFLSKLG

22861399147689774tt78
type: Position
type: ExactPosition
position: 78
reference: MDLLTAKTIVLGCSAVGAGLAMIAGLGPGIGEGYAAGKAVESVARQPEARGSIISTMILGQAVAESTGIYSLVIALILLYANPFLSKLG

SIP67365AB1F780B739
type: Site Annotation
comment: Reversibly protonated during proton transport
range: 22861399147689774tt65tt65

22861399147689774tt65
type: Position
type: ExactPosition
position: 65
reference: MDLLTAKTIVLGCSAVGAGLAMIAGLGPGIGEGYAAGKAVESVARQPEARGSIISTMILGQAVAESTGIYSLVIALILLYANPFLSKLG

22861399147689774tt3
type: Position
type: ExactPosition
position: 3
reference: MDLLTAKTIVLGCSAVGAGLAMIAGLGPGIGEGYAAGKAVESVARQPEARGSIISTMILGQAVAESTGIYSLVIALILLYANPFLSKLG

22861399147689774tt22
type: Position
type: ExactPosition
position: 22
reference: MDLLTAKTIVLGCSAVGAGLAMIAGLGPGIGEGYAAGKAVESVARQPEARGSIISTMILGQAVAESTGIYSLVIALILLYANPFLSKLG

22861399147689774tt23
type: Position
type: ExactPosition
position: 23
reference: MDLLTAKTIVLGCSAVGAGLAMIAGLGPGIGEGYAAGKAVESVARQPEARGSIISTMILGQAVAESTGIYSLVIALILLYANPFLSKLG

22861399147689774tt25
type: Position
type: ExactPosition
position: 25
reference: MDLLTAKTIVLGCSAVGAGLAMIAGLGPGIGEGYAAGKAVESVARQPEARGSIISTMILGQAVAESTGIYSLVIALILLYANPFLSKLG

22861399147689774tt26
type: Position
type: ExactPosition
position: 26
reference: MDLLTAKTIVLGCSAVGAGLAMIAGLGPGIGEGYAAGKAVESVARQPEARGSIISTMILGQAVAESTGIYSLVIALILLYANPFLSKLG

22861399147689774tt45
type: Position
type: ExactPosition
position: 45
reference: MDLLTAKTIVLGCSAVGAGLAMIAGLGPGIGEGYAAGKAVESVARQPEARGSIISTMILGQAVAESTGIYSLVIALILLYANPFLSKLG

22861399147689774tt47
type: Position
type: ExactPosition
position: 47
reference: MDLLTAKTIVLGCSAVGAGLAMIAGLGPGIGEGYAAGKAVESVARQPEARGSIISTMILGQAVAESTGIYSLVIALILLYANPFLSKLG

22861399147689774tt49
type: Position
type: ExactPosition
position: 49
reference: MDLLTAKTIVLGCSAVGAGLAMIAGLGPGIGEGYAAGKAVESVARQPEARGSIISTMILGQAVAESTGIYSLVIALILLYANPFLSKLG

22861399147689774tt50
type: Position
type: ExactPosition
position: 50
reference: MDLLTAKTIVLGCSAVGAGLAMIAGLGPGIGEGYAAGKAVESVARQPEARGSIISTMILGQAVAESTGIYSLVIALILLYANPFLSKLG

22861399147689774tt80
type: Position
type: ExactPosition
position: 80
reference: MDLLTAKTIVLGCSAVGAGLAMIAGLGPGIGEGYAAGKAVESVARQPEARGSIISTMILGQAVAESTGIYSLVIALILLYANPFLSKLG

22861399147689774tt85
type: Position
type: ExactPosition
position: 85
reference: MDLLTAKTIVLGCSAVGAGLAMIAGLGPGIGEGYAAGKAVESVARQPEARGSIISTMILGQAVAESTGIYSLVIALILLYANPFLSKLG

22861399147689774tt87
type: Position
type: ExactPosition
position: 87
reference: MDLLTAKTIVLGCSAVGAGLAMIAGLGPGIGEGYAAGKAVESVARQPEARGSIISTMILGQAVAESTGIYSLVIALILLYANPFLSKLG

http://purl.uniprot.org/intact/16063254-16063254
type: Interaction
type: Self Interaction
xeno: false
experiments: 2
participant: atpE

atpE
type: Participant

MDLLTAKTIVLGCSAVGAGLAMIAGLGPGIGEGYAAGKAVESVARQPEARGSIISTMILGQAVAESTGIYSLVIALILLYANPFLSKLG
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 8863

http://purl.uniprot.org/uniprot/Q8RGD7#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q8RGD7#attribution-A070CC491B49E97B34086175ECA8F4F1
creator: IntAct
manual: true
evidence: ECO_0000353
source: http://purl.uniprot.org/citations/23824040

http://purl.uniprot.org/uniprot/Q8RGD7#attribution-A30093FC3652A8EBF93668C13F9E1E0F
manual: true
evidence: ECO_0000255
source: MF_01396

Q8KRV3
type: Protein
reviewed: true
created: 2009-03-03
modified: 2023-02-22
version: 89
mnemonic: ATPL_ILYTA
citation: http://purl.uniprot.org/citations/12531483
citation: http://purl.uniprot.org/citations/15860619
recommended name: SIPC3819D18A8D567BD
alternative name: SIPB0BFD942ED335F81
alternative name: SIP36C9FA1BB6433AC0
alternative name: SIP47A478988503071F
organism: http://purl.uniprot.org/taxonomy/167644
annotation: SIP425690301BBCE444
annotation: SIPC79A05F310268161
annotation: SIP306CDCC90AE5399C
annotation: SIP714F02ED5488F866
annotation: SIPD1CD38CD9C4DFD8D
annotation: SIP9BEF9E7A9CFA651A
annotation: PRO_0000365891
annotation: SIPCE73DA17F59008F5
annotation: SIPF7AA3E06EE622F21
annotation: SIP2010B02CC0D5D40D
annotation: SIP861625D0B126C48D
annotation: SIP960A48889AF66A07
annotation: SIPBBB58C0E9B6EB89B
annotation: SIPB5225F05E1648FB5
annotation: SIPC379EAB6B31DB58E
annotation: SIP009BC9E435B6B23E
annotation: SIPA35ECA37203B4246
annotation: SIPD226B078B327A118
annotation: SIPE03B4DA5DA6C032A
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/66
classified with: http://purl.uniprot.org/keywords/997
classified with: http://purl.uniprot.org/keywords/138
classified with: http://purl.uniprot.org/keywords/446
classified with: http://purl.uniprot.org/keywords/739
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0005886
classified with: GO_0045263
classified with: GO_0008289
classified with: GO_0046933
classified with: GO_0006814
sequence: MDMLFAKTVVLAASAVGAGTAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAVAESTGIYSLVIALILLYANPFVGLLG

Q8KRV3-citation-12531483
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

ATCC 35898 / DSM 2382
type: Strain

Q8KRV3-citation-15860619
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS)
scope: SUBUNIT

1YCE
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.40
chain sequence mapping: PDB 1YCE tt1tt89

PDB 1YCE tt1tt89
chain: A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/a/b/c/d/e/f/g/h/i/j/k/l/m/n/o/p/q/r/s/t/u/v=1-89

2WGM
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.35
chain sequence mapping: PDB 2WGM tt1tt89

PDB 2WGM tt1tt89
chain: A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/a/b/c/d/e/f/g/h/i/j/k/l/m/n/o/p/q/r/s/t/u/v=1-89

SIPC3819D18A8D567BD
type: Structured Name
full name: ATP synthase subunit c, sodium ion specific

SIPB0BFD942ED335F81
type: Structured Name
full name: ATP synthase F(0) sector subunit c

SIP36C9FA1BB6433AC0
type: Structured Name
full name: F-type ATPase subunit c
short name: F-ATPase subunit c

SIP47A478988503071F
type: Structured Name
full name: Lipid-binding protein

atpE
type: Gene

SIP425690301BBCE444
type: Function Annotation
comment: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane sodium channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to sodium translocation.

SIPC79A05F310268161
type: Function Annotation
comment: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of 11 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.

SIP306CDCC90AE5399C
type: Subunit Annotation
comment: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane sodium channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(11). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.

SIPD1CD38CD9C4DFD8D
type: Annotation
comment: The ATPase of I.tartaricus is of special interest because it uses sodium ions instead of protons as the physiological coupling ion.

SIP9BEF9E7A9CFA651A
type: Similarity Annotation
comment: Belongs to the ATPase C chain family.

PRO_0000365891
type: Chain Annotation
comment: ATP synthase subunit c, sodium ion specific
mass: 8795
range: 22861369268646702tt1tt89

22861369268646702tt1
type: Position
type: ExactPosition
position: 1
reference: MDMLFAKTVVLAASAVGAGTAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAVAESTGIYSLVIALILLYANPFVGLLG

22861369268646702tt89
type: Position
type: ExactPosition
position: 89
reference: MDMLFAKTVVLAASAVGAGTAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAVAESTGIYSLVIALILLYANPFVGLLG

SIPCE73DA17F59008F5
type: Topological Domain Annotation
comment: Periplasmic
range: 22861369268646702tt1tt8

22861369268646702tt8
type: Position
type: ExactPosition
position: 8
reference: MDMLFAKTVVLAASAVGAGTAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAVAESTGIYSLVIALILLYANPFVGLLG

SIPF7AA3E06EE622F21
type: Transmembrane Annotation
comment: Helical
range: 22861369268646702tt9tt29

22861369268646702tt9
type: Position
type: ExactPosition
position: 9
reference: MDMLFAKTVVLAASAVGAGTAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAVAESTGIYSLVIALILLYANPFVGLLG

22861369268646702tt29
type: Position
type: ExactPosition
position: 29
reference: MDMLFAKTVVLAASAVGAGTAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAVAESTGIYSLVIALILLYANPFVGLLG

SIP2010B02CC0D5D40D
type: Topological Domain Annotation
comment: Cytoplasmic
range: 22861369268646702tt30tt67

22861369268646702tt30
type: Position
type: ExactPosition
position: 30
reference: MDMLFAKTVVLAASAVGAGTAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAVAESTGIYSLVIALILLYANPFVGLLG

22861369268646702tt67
type: Position
type: ExactPosition
position: 67
reference: MDMLFAKTVVLAASAVGAGTAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAVAESTGIYSLVIALILLYANPFVGLLG

SIP861625D0B126C48D
type: Transmembrane Annotation
comment: Helical
range: 22861369268646702tt68tt88

22861369268646702tt68
type: Position
type: ExactPosition
position: 68
reference: MDMLFAKTVVLAASAVGAGTAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAVAESTGIYSLVIALILLYANPFVGLLG

22861369268646702tt88
type: Position
type: ExactPosition
position: 88
reference: MDMLFAKTVVLAASAVGAGTAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAVAESTGIYSLVIALILLYANPFVGLLG

SIP960A48889AF66A07
type: Topological Domain Annotation
comment: Periplasmic
range: 22861369268646702tt89tt89

SIPBBB58C0E9B6EB89B
type: Site Annotation
comment: Reversibly binds sodium during transport
range: 22861369268646702tt65tt65

22861369268646702tt65
type: Position
type: ExactPosition
position: 65
reference: MDMLFAKTVVLAASAVGAGTAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAVAESTGIYSLVIALILLYANPFVGLLG

22861369268646702tt3
type: Position
type: ExactPosition
position: 3
reference: MDMLFAKTVVLAASAVGAGTAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAVAESTGIYSLVIALILLYANPFVGLLG

22861369268646702tt21
type: Position
type: ExactPosition
position: 21
reference: MDMLFAKTVVLAASAVGAGTAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAVAESTGIYSLVIALILLYANPFVGLLG

22861369268646702tt22
type: Position
type: ExactPosition
position: 22
reference: MDMLFAKTVVLAASAVGAGTAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAVAESTGIYSLVIALILLYANPFVGLLG

22861369268646702tt25
type: Position
type: ExactPosition
position: 25
reference: MDMLFAKTVVLAASAVGAGTAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAVAESTGIYSLVIALILLYANPFVGLLG

22861369268646702tt26
type: Position
type: ExactPosition
position: 26
reference: MDMLFAKTVVLAASAVGAGTAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAVAESTGIYSLVIALILLYANPFVGLLG

22861369268646702tt45
type: Position
type: ExactPosition
position: 45
reference: MDMLFAKTVVLAASAVGAGTAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAVAESTGIYSLVIALILLYANPFVGLLG

22861369268646702tt47
type: Position
type: ExactPosition
position: 47
reference: MDMLFAKTVVLAASAVGAGTAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAVAESTGIYSLVIALILLYANPFVGLLG

22861369268646702tt49
type: Position
type: ExactPosition
position: 49
reference: MDMLFAKTVVLAASAVGAGTAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAVAESTGIYSLVIALILLYANPFVGLLG

22861369268646702tt50
type: Position
type: ExactPosition
position: 50
reference: MDMLFAKTVVLAASAVGAGTAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAVAESTGIYSLVIALILLYANPFVGLLG

22861369268646702tt80
type: Position
type: ExactPosition
position: 80
reference: MDMLFAKTVVLAASAVGAGTAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAVAESTGIYSLVIALILLYANPFVGLLG

22861369268646702tt85
type: Position
type: ExactPosition
position: 85
reference: MDMLFAKTVVLAASAVGAGTAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAVAESTGIYSLVIALILLYANPFVGLLG

22861369268646702tt87
type: Position
type: ExactPosition
position: 87
reference: MDMLFAKTVVLAASAVGAGTAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAVAESTGIYSLVIALILLYANPFVGLLG

MDMLFAKTVVLAASAVGAGTAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAVAESTGIYSLVIALILLYANPFVGLLG
type: Simple Sequence
modified: 2002-10-01
version: 1
mass: 8795

http://purl.uniprot.org/uniprot/Q8KRV3#attribution-DC036A124EC8E88DF072B29F6D9BB9FE
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/Q8KRV3#attribution-DD1F045F6B881D63686C6C76A5C051F1
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/15860619

http://purl.uniprot.org/uniprot/Q8KRV3#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

P21905
type: Protein
reviewed: true
created: 1991-05-01
modified: 2023-02-22
version: 118
mnemonic: ATPL_PROMO
old mnemonic: ATNC_PROMO
citation: http://purl.uniprot.org/citations/2146118
citation: http://purl.uniprot.org/citations/1386022
citation: http://purl.uniprot.org/citations/2170948
citation: http://purl.uniprot.org/citations/8422943
citation: http://purl.uniprot.org/citations/1533602
recommended name: SIPC3819D18A8D567BD
alternative name: SIPB0BFD942ED335F81
alternative name: SIP36C9FA1BB6433AC0
alternative name: SIP47A478988503071F
organism: http://purl.uniprot.org/taxonomy/2333
annotation: SIP7E4FA8DD372736AF
annotation: SIP11F27FEA5B564F3B
annotation: SIP868DD1416EE033D1
annotation: SIP14CC66570D6D7BF2
annotation: SIP1DA28048F85DB80C
annotation: SIP2ACF260BB56B5802
annotation: PRO_0000112158
annotation: SIP69440D8E1AE7B93C
annotation: SIP2459C02AEA3E1CD4
annotation: SIP77448FACA44C6EC7
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/66
classified with: http://purl.uniprot.org/keywords/1003
classified with: http://purl.uniprot.org/keywords/138
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/446
classified with: http://purl.uniprot.org/keywords/739
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0005886
classified with: GO_0045263
classified with: GO_0008289
classified with: GO_0046933
classified with: GO_0006814
sequence: MDMVLAKTVVLAASAVGAGAAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAIAESTGIYSLVIALILLYANPFVGLLG

P21905-citation-2146118
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: PROTEIN SEQUENCE OF 1-34

DSM 2376 / Gra Succ2
type: Strain

P21905-citation-1386022
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

P21905-citation-2170948
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

P21905-citation-8422943
type: Citation Statement
scope: PROTEIN SEQUENCE OF 1-7

P21905-citation-1533602
type: Citation Statement
scope: DISCUSSION OF SEQUENCE

DB03143
type: Resource
database: DrugBank
comment: Nonan-1-Ol

SIPC3819D18A8D567BD
type: Structured Name
full name: ATP synthase subunit c, sodium ion specific

SIPB0BFD942ED335F81
type: Structured Name
full name: ATP synthase F(0) sector subunit c

SIP36C9FA1BB6433AC0
type: Structured Name
full name: F-type ATPase subunit c
short name: F-ATPase subunit c

SIP47A478988503071F
type: Structured Name
full name: Lipid-binding protein

atpE
type: Gene
alternative label: uncE

SIP7E4FA8DD372736AF
type: Function Annotation
comment: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane sodium channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to sodium translocation.

SIP11F27FEA5B564F3B
type: Function Annotation
comment: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits (Probable).

SIP868DD1416EE033D1
type: Subunit Annotation
comment: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane sodium channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains (By similarity).

SIP1DA28048F85DB80C
type: Annotation
comment: The ATPase of P.modestum is of special interest because it uses sodium ions instead of protons as the physiological coupling ion.

SIP2ACF260BB56B5802
type: Similarity Annotation
comment: Belongs to the ATPase C chain family.

PRO_0000112158
type: Chain Annotation
comment: ATP synthase subunit c, sodium ion specific
mass: 8731
range: 22573185131099438tt1tt89

22573185131099438tt1
type: Position
type: ExactPosition
position: 1
reference: MDMVLAKTVVLAASAVGAGAAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAIAESTGIYSLVIALILLYANPFVGLLG

22573185131099438tt89
type: Position
type: ExactPosition
position: 89
reference: MDMVLAKTVVLAASAVGAGAAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAIAESTGIYSLVIALILLYANPFVGLLG

SIP69440D8E1AE7B93C
type: Transmembrane Annotation
comment: Helical
range: 22573185131099438tt9tt29

22573185131099438tt9
type: Position
type: ExactPosition
position: 9
reference: MDMVLAKTVVLAASAVGAGAAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAIAESTGIYSLVIALILLYANPFVGLLG

22573185131099438tt29
type: Position
type: ExactPosition
position: 29
reference: MDMVLAKTVVLAASAVGAGAAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAIAESTGIYSLVIALILLYANPFVGLLG

SIP2459C02AEA3E1CD4
type: Transmembrane Annotation
comment: Helical
range: 22573185131099438tt68tt88

22573185131099438tt68
type: Position
type: ExactPosition
position: 68
reference: MDMVLAKTVVLAASAVGAGAAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAIAESTGIYSLVIALILLYANPFVGLLG

22573185131099438tt88
type: Position
type: ExactPosition
position: 88
reference: MDMVLAKTVVLAASAVGAGAAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAIAESTGIYSLVIALILLYANPFVGLLG

SIP77448FACA44C6EC7
type: Site Annotation
comment: Reversibly binds sodium during transport
range: 22573185131099438tt65tt65

22573185131099438tt65
type: Position
type: ExactPosition
position: 65
reference: MDMVLAKTVVLAASAVGAGAAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAIAESTGIYSLVIALILLYANPFVGLLG

MDMVLAKTVVLAASAVGAGAAMIAGIGPGVGQGYAAGKAVESVARQPEAKGDIISTMVLGQAIAESTGIYSLVIALILLYANPFVGLLG
type: Simple Sequence
modified: 1991-05-01
version: 1
mass: 8731

http://purl.uniprot.org/uniprot/P21905#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/P21905#attribution-DC036A124EC8E88DF072B29F6D9BB9FE
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/P21905#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

P29705
type: Protein
reviewed: true
created: 1993-04-01
modified: 2022-12-14
version: 71
mnemonic: ATPZ_PROMO
citation: http://purl.uniprot.org/citations/1386022
citation: http://purl.uniprot.org/citations/2170948
citation: http://purl.uniprot.org/citations/1533602
recommended name: SIPA1C8BB57678FA403
organism: http://purl.uniprot.org/taxonomy/2333
annotation: SIPA39B5BD8C73E610F
annotation: SIP9DC9234618EA832E
annotation: SIPC1DD6B94C0065BAA
annotation: SIPCCFBD01AD07387BF
annotation: PRO_0000071709
annotation: SIP0E2F6DDA55F0B66A
annotation: SIPD26A3962DD790124
annotation: SIP133F789E98CACCC0
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/1003
classified with: http://purl.uniprot.org/keywords/138
classified with: http://purl.uniprot.org/keywords/739
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0005886
classified with: GO_0045263
classified with: GO_1902600
classified with: GO_0006814
sequence: MNQEIKKILKNSLITSLIVLVYGIVVRNPIVYFGMFVGCLISTFCFYMICQEAESAMKSGSPFKMTVTGYMKRYAIYGIYLGILVKFFGFPVFLGGAVGLLNIKFNIFLKVVSTQFEKIKKKLSSLK

P29705-citation-1386022
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

DSM 2376 / Gra Succ2
type: Strain

P29705-citation-2170948
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

P29705-citation-1533602
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

1.A.77.3.29
type: Resource
database: TCDB
comment: the mg(2+)/ca(2+) uniporter (mcu) family

IPR005598
type: Resource
database: InterPro
comment: ATP_synth_I

PF03899
type: Resource
database: Pfam
comment: ATP-synt_I
signature sequence match: Pfam PF03899 match 1

SIPA1C8BB57678FA403
type: Structured Name
full name: ATP synthase protein I, sodium ion specific

atpI
type: Gene
alternative label: uncI

SIPA39B5BD8C73E610F
type: Function Annotation
comment: A possible function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex.

SIPC1DD6B94C0065BAA
type: Annotation
comment: The ATPase of P.modestum is of special interest because it uses sodium ions instead of protons as the physiological coupling ion.

SIPCCFBD01AD07387BF
type: Similarity Annotation
comment: Belongs to the bacterial AtpI family.

PRO_0000071709
type: Chain Annotation
comment: ATP synthase protein I, sodium ion specific
mass: 14338
range: 22573219457283374tt1tt127

22573219457283374tt1
type: Position
type: ExactPosition
position: 1
reference: MNQEIKKILKNSLITSLIVLVYGIVVRNPIVYFGMFVGCLISTFCFYMICQEAESAMKSGSPFKMTVTGYMKRYAIYGIYLGILVKFFGFPVFLGGAVGLLNIKFNIFLKVVSTQFEKIKKKLSSLK

22573219457283374tt127
type: Position
type: ExactPosition
position: 127
reference: MNQEIKKILKNSLITSLIVLVYGIVVRNPIVYFGMFVGCLISTFCFYMICQEAESAMKSGSPFKMTVTGYMKRYAIYGIYLGILVKFFGFPVFLGGAVGLLNIKFNIFLKVVSTQFEKIKKKLSSLK

SIP0E2F6DDA55F0B66A
type: Transmembrane Annotation
comment: Helical
range: 22573219457283374tt5tt25

22573219457283374tt5
type: Position
type: ExactPosition
position: 5
reference: MNQEIKKILKNSLITSLIVLVYGIVVRNPIVYFGMFVGCLISTFCFYMICQEAESAMKSGSPFKMTVTGYMKRYAIYGIYLGILVKFFGFPVFLGGAVGLLNIKFNIFLKVVSTQFEKIKKKLSSLK

22573219457283374tt25
type: Position
type: ExactPosition
position: 25
reference: MNQEIKKILKNSLITSLIVLVYGIVVRNPIVYFGMFVGCLISTFCFYMICQEAESAMKSGSPFKMTVTGYMKRYAIYGIYLGILVKFFGFPVFLGGAVGLLNIKFNIFLKVVSTQFEKIKKKLSSLK

SIPD26A3962DD790124
type: Transmembrane Annotation
comment: Helical
range: 22573219457283374tt30tt50

22573219457283374tt30
type: Position
type: ExactPosition
position: 30
reference: MNQEIKKILKNSLITSLIVLVYGIVVRNPIVYFGMFVGCLISTFCFYMICQEAESAMKSGSPFKMTVTGYMKRYAIYGIYLGILVKFFGFPVFLGGAVGLLNIKFNIFLKVVSTQFEKIKKKLSSLK

22573219457283374tt50
type: Position
type: ExactPosition
position: 50
reference: MNQEIKKILKNSLITSLIVLVYGIVVRNPIVYFGMFVGCLISTFCFYMICQEAESAMKSGSPFKMTVTGYMKRYAIYGIYLGILVKFFGFPVFLGGAVGLLNIKFNIFLKVVSTQFEKIKKKLSSLK

SIP133F789E98CACCC0
type: Transmembrane Annotation
comment: Helical
range: 22573219457283374tt81tt101

22573219457283374tt81
type: Position
type: ExactPosition
position: 81
reference: MNQEIKKILKNSLITSLIVLVYGIVVRNPIVYFGMFVGCLISTFCFYMICQEAESAMKSGSPFKMTVTGYMKRYAIYGIYLGILVKFFGFPVFLGGAVGLLNIKFNIFLKVVSTQFEKIKKKLSSLK

22573219457283374tt101
type: Position
type: ExactPosition
position: 101
reference: MNQEIKKILKNSLITSLIVLVYGIVVRNPIVYFGMFVGCLISTFCFYMICQEAESAMKSGSPFKMTVTGYMKRYAIYGIYLGILVKFFGFPVFLGGAVGLLNIKFNIFLKVVSTQFEKIKKKLSSLK

MNQEIKKILKNSLITSLIVLVYGIVVRNPIVYFGMFVGCLISTFCFYMICQEAESAMKSGSPFKMTVTGYMKRYAIYGIYLGILVKFFGFPVFLGGAVGLLNIKFNIFLKVVSTQFEKIKKKLSSLK
type: Simple Sequence
modified: 1993-04-01
version: 1
mass: 14338

http://purl.uniprot.org/uniprot/P29705#attribution-DC036A124EC8E88DF072B29F6D9BB9FE
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/P29705#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

Q8REU0
type: Protein
reviewed: true
created: 2009-07-28
modified: 2023-02-22
version: 115
mnemonic: BIOB_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIPBB15AFB22594DDF3
enzyme: http://purl.uniprot.org/enzyme/2.8.1.6
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIP25A9BD3A38C0BCCD
annotation: SIP8ACC6978FD782ED7
annotation: SIP0E9DAD2B09629D2F
annotation: SIP7D47D2EA0DEFEF60
annotation: SIP7C018AD2854C9798
annotation: SIP705A6683674E0202
annotation: SIPE97EE7E33FC9F551
annotation: PRO_0000381399
annotation: SIPFBC9CCB4FC452323
annotation: SIP1F2862B65C8EC322
annotation: SIP220EB63DD26C21F1
annotation: SIP7A6DA9CC4F21229D
annotation: SIP66F3FADA60FD3F91
annotation: SIPCE9930C525607089
annotation: SIP35AA03298B3D0517
annotation: SIPD804507B0A440354
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/1
classified with: http://purl.uniprot.org/keywords/4
classified with: http://purl.uniprot.org/keywords/93
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/949
classified with: http://purl.uniprot.org/keywords/808
classified with: GO_0051537
classified with: GO_0051539
classified with: GO_0004076
classified with: GO_0005506
classified with: GO_0009102
sequence: Q8REU0-1
proteome: Chromosome

Q8REU0-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG0502
type: Resource
database: eggNOG
comment: Bacteria

cd01335
type: Resource
database: CDD
comment: Radical_SAM
signature sequence match: CDD cd01335 match 1

MF_01694
type: Resource
database: HAMAP
comment: BioB
signature sequence match: HAMAP MF 01694 match 1

IPR010722
type: Resource
database: InterPro
comment: BATS_dom

IPR002684
type: Resource
database: InterPro
comment: Biotin_synth/BioAB

IPR024177
type: Resource
database: InterPro
comment: Biotin_synthase

IPR006638
type: Resource
database: InterPro
comment: Elp3/MiaA/NifB-like_rSAM

IPR007197
type: Resource
database: InterPro
comment: rSAM

PTHR22976
type: Resource
database: PANTHER
comment: BIOTIN SYNTHASE
signature sequence match: PANTHER PTHR22976 match 1

PTHR22976:SF2
type: Resource
database: PANTHER
comment: BIOTIN SYNTHASE, MITOCHONDRIAL
signature sequence match: PANTHER PTHR22976:SF2 match 1

PF06968
type: Resource
database: Pfam
comment: BATS
signature sequence match: Pfam PF06968 match 1

PF04055
type: Resource
database: Pfam
comment: Radical_SAM
signature sequence match: Pfam PF04055 match 1

PIRSF001619
type: Resource
database: PIRSF
comment: Biotin_synth
signature sequence match: PIRSF PIRSF001619 match 1

SFLDG01060
type: Resource
database: SFLD
comment: BATS_domain_containing
signature sequence match: SFLD SFLDG01060 match 1

SFLDG01278
type: Resource
database: SFLD
comment: biotin_synthase_like
signature sequence match: SFLD SFLDG01278 match 1

SM00876
type: Resource
database: SMART
comment: BATS
signature sequence match: SMART SM00876 match 1

SM00729
type: Resource
database: SMART
comment: Elp3
signature sequence match: SMART SM00729 match 1

SSF102114
type: Resource
database: SUPFAM
comment: Radical SAM enzymes
signature sequence match: SUPFAM SSF102114 match 1

TIGR00433
type: Resource
database: TIGRFAMs
comment: bioB
signature sequence match: TIGRFAMs TIGR00433 match 1

PS51918
type: Resource
database: PROSITE
comment: RADICAL_SAM
signature sequence match: PROSITE PS51918 match 1

SIPBB15AFB22594DDF3
type: Structured Name
full name: Biotin synthase
ec name: 2.8.1.6

bioB
type: Gene
locus name: FN1000

SIP25A9BD3A38C0BCCD
type: Function Annotation
comment: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.

SIP0E9DAD2B09629D2F
type: Cofactor Annotation
comment: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
cofactor: CHEBI_49883

SIP7D47D2EA0DEFEF60
type: Cofactor Annotation
comment: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
cofactor: CHEBI_190135

SIP705A6683674E0202
type: Subunit Annotation
comment: Homodimer.

SIPE97EE7E33FC9F551
type: Similarity Annotation
comment: Belongs to the radical SAM superfamily. Biotin synthase family.

PRO_0000381399
type: Chain Annotation
comment: Biotin synthase
mass: 40450
range: 22861399115247662tt1tt360

22861399115247662tt1
type: Position
type: ExactPosition
position: 1
reference: Q8REU0-1

22861399115247662tt360
type: Position
type: ExactPosition
position: 360
reference: Q8REU0-1

SIPFBC9CCB4FC452323
type: Domain Extent Annotation
comment: Radical SAM core
range: 22861399115247662tt83tt315

22861399115247662tt83
type: Position
type: ExactPosition
position: 83
reference: Q8REU0-1

22861399115247662tt315
type: Position
type: ExactPosition
position: 315
reference: Q8REU0-1

22861399115247662tt101
type: Position
type: ExactPosition
position: 101
reference: Q8REU0-1

22861399115247662tt105
type: Position
type: ExactPosition
position: 105
reference: Q8REU0-1

22861399115247662tt108
type: Position
type: ExactPosition
position: 108
reference: Q8REU0-1

22861399115247662tt145
type: Position
type: ExactPosition
position: 145
reference: Q8REU0-1

22861399115247662tt180
type: Position
type: ExactPosition
position: 180
reference: Q8REU0-1

22861399115247662tt240
type: Position
type: ExactPosition
position: 240
reference: Q8REU0-1

22861399115247662tt310
type: Position
type: ExactPosition
position: 310
reference: Q8REU0-1

SIP0EB8875058CDA956
subclass of: CHEBI_49883
comment: 4Fe-4S-S-AdoMet

Q8REU0-1
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 40450
value: MLKEKNSAGGGKFNFFNFLKEKDNNQAEPSNVKEFISYLKNKIINEKYEITREEAIFLSQIPNNDMETLNILFNAADQIREVFCGKYFDLCTIINAKSGKCSENCKYCAQSVHFKTGTDVYGLISKELALYEAKRNENEGAHRFSLVTSGRGLNGNEKELDKLVEIYKYIGEHTSKLELCASHGICTKEALQKLVDAGVLTYHHNLESSRRFYPNVCTSHSYDDRINTIKNAKAVGLDVCSGGIFGLGETIEDRIDMALDLRALEIHSVPINVLTPIPGTPFENNEEVNPFEILKTISIYRFIMPKSFLRYCGGRIKLGEHAKTGLRCGINSALTGNFLTTTGTTIETDKKMIKELGYEI

http://purl.uniprot.org/uniprot/Q8REU0#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q8REU0#attribution-55428B9244A0EC48C2387090F66C8227
manual: true
evidence: ECO_0000255
source: MF_01694

http://purl.uniprot.org/uniprot/Q8REU0#attribution-3F4EA4141FE4507DF0695D0A72C2893B
manual: true
evidence: ECO_0000255
source: PRU01266

E3H9W1
type: Protein
reviewed: true
created: 2011-09-21
modified: 2023-02-22
version: 60
mnemonic: BIOC1_ILYPC
citation: http://purl.uniprot.org/citations/21304735
recommended name: SIPCB42CFB3CFE7374F
alternative name: SIP091A866795A41C27
enzyme: http://purl.uniprot.org/enzyme/2.1.1.197
organism: http://purl.uniprot.org/taxonomy/572544
annotation: SIPC4AFD030C5FA9CE0
annotation: SIP1AB91BDC5573C852
annotation: SIP520BAFC261F645E6
annotation: SIP6C9D004DC042CCC8
annotation: PRO_0000412505
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/93
classified with: http://purl.uniprot.org/keywords/489
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/949
classified with: GO_0010340
classified with: GO_0102130
classified with: GO_0009102
classified with: GO_0032259
sequence: E3H9W1-1
proteome: Chromosome

E3H9W1-citation-21304735
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 51220 / DSM 2926 / LMG 16218 / CuHBu1
type: Strain

COG4106
type: Resource
database: eggNOG
comment: Bacteria

cd02440
type: Resource
database: CDD
comment: AdoMet_MTases
signature sequence match: CDD cd02440 match 1

http://purl.uniprot.org/gene3d/3.40.50.150
type: Resource
database: Gene3D
comment: Vaccinia Virus protein VP39
signature sequence match: Gene3D 3.40.50.150 match 1

MF_00835
type: Resource
database: HAMAP
comment: BioC
signature sequence match: HAMAP MF 00835 match 1

IPR011814
type: Resource
database: InterPro
comment: BioC

IPR041698
type: Resource
database: InterPro
comment: Methyltransf_25

IPR029063
type: Resource
database: InterPro
comment: SAM-dependent_MTases_sf

PTHR43861:SF1
type: Resource
database: PANTHER
comment: TRANS-ACONITATE 2-METHYLTRANSFERASE
signature sequence match: PANTHER PTHR43861:SF1 match 1

PTHR43861
type: Resource
database: PANTHER
comment: TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED
signature sequence match: PANTHER PTHR43861 match 1

PF13649
type: Resource
database: Pfam
comment: Methyltransf_25
signature sequence match: Pfam PF13649 match 1

SSF53335
type: Resource
database: SUPFAM
comment: S-adenosyl-L-methionine-dependent methyltransferases
signature sequence match: SUPFAM SSF53335 match 1

TIGR02072
type: Resource
database: TIGRFAMs
comment: BioC
signature sequence match: TIGRFAMs TIGR02072 match 1

SIPCB42CFB3CFE7374F
type: Structured Name
full name: Malonyl-[acyl-carrier protein] O-methyltransferase 1
short name: Malonyl-ACP O-methyltransferase 1
ec name: 2.1.1.197

SIP091A866795A41C27
type: Structured Name
full name: Biotin synthesis protein BioC 1

bioC1
type: Gene
locus name: Ilyop_0229

SIPC4AFD030C5FA9CE0
type: Function Annotation
comment: Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.

SIP6C9D004DC042CCC8
type: Similarity Annotation
comment: Belongs to the methyltransferase superfamily.

PRO_0000412505
type: Chain Annotation
comment: Malonyl-[acyl-carrier protein] O-methyltransferase 1
mass: 31219
range: 19478158685712686tt1tt268

19478158685712686tt1
type: Position
type: ExactPosition
position: 1
reference: E3H9W1-1

19478158685712686tt268
type: Position
type: ExactPosition
position: 268
reference: E3H9W1-1

E3H9W1-1
type: Simple Sequence
modified: 2011-01-11
version: 1
mass: 31219
value: MAIIDKKRVNQNFSRGAKTYDNYAQVQKHMADKLEIFVHGSKKQYNILEVGCGTGIFSQKILKRFPNSKIDLLDISPAMVETAKEKLGDSPNLNFIVEDVENYNPEKKYDLIFSNATFQWIDDQMRLFNHLYSLLDYGGKIAFSTFGNKTYFELRESLSTLDPELKYSQKFVKLDEMTEITNKNFRILAADEDFFIEKFENVMAFLKAIKGIGSNSALSNKRNFTREKFKALDKIYRDKFGDKNIINVTNHLLYMVLEKVKMRDENLK

http://purl.uniprot.org/uniprot/E3H9W1#attribution-6448A76D30AB5DCC2A22F5E61DB34D63
manual: true
evidence: ECO_0000255
source: MF_00835

E3HCT1
type: Protein
reviewed: true
created: 2011-09-21
modified: 2023-02-22
version: 52
mnemonic: BIOC2_ILYPC
citation: http://purl.uniprot.org/citations/21304735
recommended name: SIPCC00A1FD4B3DE3E7
alternative name: SIP648C6C6D1D4967B6
enzyme: http://purl.uniprot.org/enzyme/2.1.1.197
organism: http://purl.uniprot.org/taxonomy/572544
encoded in: pILYOP01
annotation: SIP3A40525AF9E85D70
annotation: SIP6567801BF4F3C6AF
annotation: SIPA1AEA93006A22138
annotation: SIP15DA6D19A05342A8
annotation: PRO_0000412506
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/93
classified with: http://purl.uniprot.org/keywords/489
classified with: http://purl.uniprot.org/keywords/614
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/949
classified with: GO_0010340
classified with: GO_0102130
classified with: GO_0009102
classified with: GO_0032259
sequence: E3HCT1-1
proteome: Plasmid pILYOP01

E3HCT1-citation-21304735
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 51220 / DSM 2926 / LMG 16218 / CuHBu1
type: Strain

PTHR43591
type: Resource
database: PANTHER
comment: METHYLTRANSFERASE
signature sequence match: PANTHER PTHR43591 match 1

PTHR43591:SF101
type: Resource
database: PANTHER
comment: METHYLTRANSFERASE-LIKE PROTEIN 27
signature sequence match: PANTHER PTHR43591:SF101 match 1

PF13489
type: Resource
database: Pfam
comment: Methyltransf_23
signature sequence match: Pfam PF13489 match 1

SIPCC00A1FD4B3DE3E7
type: Structured Name
full name: Malonyl-[acyl-carrier protein] O-methyltransferase 2
short name: Malonyl-ACP O-methyltransferase 2
ec name: 2.1.1.197

SIP648C6C6D1D4967B6
type: Structured Name
full name: Biotin synthesis protein BioC 2

pILYOP01
type: Plasmid

bioC2
type: Gene
locus name: Ilyop_2721

SIP3A40525AF9E85D70
type: Function Annotation
comment: Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.

SIP15DA6D19A05342A8
type: Similarity Annotation
comment: Belongs to the methyltransferase superfamily.

PRO_0000412506
type: Chain Annotation
comment: Malonyl-[acyl-carrier protein] O-methyltransferase 2
mass: 30192
range: 19478158853288238tt1tt259

19478158853288238tt1
type: Position
type: ExactPosition
position: 1
reference: E3HCT1-1

19478158853288238tt259
type: Position
type: ExactPosition
position: 259
reference: E3HCT1-1

E3HCT1-1
type: Simple Sequence
modified: 2011-01-11
version: 1
mass: 30192
value: MIDKKKVNRNFSKGAKTYDEYALIQRHMADKLGIFIEDSEEVFNILEIGCGTGIFSEKILNKFPNSNIDFLDISHDMIKNVKDKIGSKENLNFIVEDIEKYQPQKKYDLIFSNATFQWIQNKKGLFDHLDSFLKPGGLILFSTFGKDTYFELRESLKSIDPDLEYSQNFISLEDLKKVLDDKYKILAAEEERIKENYHCVMDFLKMIKGIGANSALSNSKPFTRDKFNRLEDEYRKNYCSGDSIEVTNHLIYMILGKNY

http://purl.uniprot.org/uniprot/E3HCT1#attribution-6448A76D30AB5DCC2A22F5E61DB34D63
manual: true
evidence: ECO_0000255
source: MF_00835

Q8RET9
type: Protein
reviewed: true
created: 2002-10-25
modified: 2023-02-22
version: 108
mnemonic: BIOD_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIP7279B3F6E4E89E2E
alternative name: SIP861E91FCCA1316D2
alternative name: SIPF9BBE94D19CA5B50
enzyme: http://purl.uniprot.org/enzyme/6.3.3.3
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIPDCC10FD55A75F818
annotation: SIP61016575F17FF8B1
annotation: SIP210C9051114B76E4
annotation: SIP40E49284DA7F8FF6
annotation: SIPD5E138B0A2D4E2BE
annotation: SIPFB4EF82C9D4B7606
annotation: SIP746FAD10EC04D10B
annotation: PRO_0000187966
annotation: SIPC9771213B91738F6
annotation: SIP2D503E40DB7FCBDB
annotation: SIP2BADE4B546E7B657
annotation: SIPFDB5379826A02369
annotation: SIPEFE57BDD9D3F3571
annotation: SIP14D6C0896945B346
annotation: SIP70B37320A29E32A7
annotation: SIPA56691F998D2EE8C
annotation: SIP5F490E77FB98A61A
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/93
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/436
classified with: http://purl.uniprot.org/keywords/460
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005829
classified with: GO_0005524
classified with: GO_0004141
classified with: GO_0000287
classified with: GO_0009102
sequence: Q8RET9-1
proteome: Chromosome

Q8RET9-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG0132
type: Resource
database: eggNOG
comment: Bacteria

cd03109
type: Resource
database: CDD
comment: DTBS
signature sequence match: CDD cd03109 match 1

MF_00336
type: Resource
database: HAMAP
comment: BioD
signature sequence match: HAMAP MF 00336 match 1

IPR004472
type: Resource
database: InterPro
comment: DTB_synth_BioD

PTHR43210
type: Resource
database: PANTHER
comment: DETHIOBIOTIN SYNTHETASE
signature sequence match: PANTHER PTHR43210 match 1

PTHR43210:SF2
type: Resource
database: PANTHER
comment: DETHIOBIOTIN SYNTHETASE
signature sequence match: PANTHER PTHR43210:SF2 match 1

PF13500
type: Resource
database: Pfam
comment: AAA_26
signature sequence match: Pfam PF13500 match 1

PIRSF006755
type: Resource
database: PIRSF
comment: DTB_synth
signature sequence match: PIRSF PIRSF006755 match 1

TIGR00347
type: Resource
database: TIGRFAMs
comment: bioD
signature sequence match: TIGRFAMs TIGR00347 match 1

SIP7279B3F6E4E89E2E
type: Structured Name
full name: ATP-dependent dethiobiotin synthetase BioD
ec name: 6.3.3.3

SIP861E91FCCA1316D2
type: Structured Name
full name: DTB synthetase
short name: DTBS

SIPF9BBE94D19CA5B50
type: Structured Name
full name: Dethiobiotin synthase

bioD
type: Gene
locus name: FN1001

SIPDCC10FD55A75F818
type: Function Annotation
comment: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.

SIPD5E138B0A2D4E2BE
type: Subunit Annotation
comment: Homodimer.

SIP746FAD10EC04D10B
type: Similarity Annotation
comment: Belongs to the dethiobiotin synthetase family.

PRO_0000187966
type: Chain Annotation
comment: ATP-dependent dethiobiotin synthetase BioD
mass: 25149
range: 22861399115184430tt1tt219

22861399115184430tt1
type: Position
type: ExactPosition
position: 1
reference: Q8RET9-1

22861399115184430tt219
type: Position
type: ExactPosition
position: 219
reference: Q8RET9-1

22861399115184430tt37
type: Position
type: ExactPosition
position: 37
reference: Q8RET9-1

22861399115184430tt14
type: Position
type: ExactPosition
position: 14
reference: Q8RET9-1

22861399115184430tt19
type: Position
type: ExactPosition
position: 19
reference: Q8RET9-1

22861399115184430tt18
type: Position
type: ExactPosition
position: 18
reference: Q8RET9-1

22861399115184430tt41
type: Position
type: ExactPosition
position: 41
reference: Q8RET9-1

22861399115184430tt54
type: Position
type: ExactPosition
position: 54
reference: Q8RET9-1

22861399115184430tt114
type: Position
type: ExactPosition
position: 114
reference: Q8RET9-1

22861399115184430tt117
type: Position
type: ExactPosition
position: 117
reference: Q8RET9-1

22861399115184430tt175
type: Position
type: ExactPosition
position: 175
reference: Q8RET9-1

22861399115184430tt176
type: Position
type: ExactPosition
position: 176
reference: Q8RET9-1

substrate

Q8RET9-1
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 25149
value: MKFKDFFVIGTDTDVGKTYVSTLLYKALKKYNFQYYKPIQSGCFLKDGKLTAPDVDFLTKFVGIDYDDSMVTYTLKEEVSPHLASEMEGIRIEIENVKRHYEDLKKKHSNILVEGAGGLYVPLIRDIFYIYDLIKLFNLPVVLVCGTKVGAINHTMLTLNALDTMGIKLHGLVFNNYRGQFFEDDNIKVVLALSKIKNYLIIKNGQKEISDKEIEKFFN

http://purl.uniprot.org/uniprot/Q8RET9#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q8RET9#attribution-9C497BC303592833BAC5F2A7F6EC53D8
manual: true
evidence: ECO_0000255
source: MF_00336

Q8RG87
type: Protein
reviewed: true
created: 2002-07-11
modified: 2023-05-03
version: 125
mnemonic: CARA_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIP1E2AAD5826F81973
alternative name: SIP5D1781685ADDA81F
enzyme: http://purl.uniprot.org/enzyme/6.3.5.5
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIP826DF3C85861A6E0
annotation: SIP5C1E49F0E251F379
annotation: SIP4931CCC345AFBB43
annotation: SIP320FD1D0975DA28A
annotation: SIP833ECB13AFF08053
annotation: PRO_0000112278
annotation: SIPD94FC89FB29F3E62
annotation: SIP210684632962E05C
annotation: SIP794D33FA38C1D475
annotation: SIP6C4804B36A871F71
annotation: SIP2D41AC4AC093BC68
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/55
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/315
classified with: http://purl.uniprot.org/keywords/436
classified with: http://purl.uniprot.org/keywords/665
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005951
classified with: GO_0005737
classified with: GO_0005524
classified with: GO_0004088
classified with: GO_0006207
classified with: GO_0044205
classified with: GO_0006526
classified with: GO_0006541
sequence: Q8RG87-1
proteome: Chromosome

Q8RG87-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG0505
type: Resource
database: eggNOG
comment: Bacteria

cd01744
type: Resource
database: CDD
comment: GATase1_CPSase
signature sequence match: CDD cd01744 match 1

http://purl.uniprot.org/gene3d/3.50.30.20
type: Resource
database: Gene3D
comment: Carbamoyl-phosphate synthase small subunit, N-terminal domain
signature sequence match: Gene3D 3.50.30.20 match 1

MF_01209
type: Resource
database: HAMAP
comment: CPSase_S_chain
signature sequence match: HAMAP MF 01209 match 1

IPR006274
type: Resource
database: InterPro
comment: CarbamoylP_synth_ssu

IPR002474
type: Resource
database: InterPro
comment: CarbamoylP_synth_ssu_N

IPR036480
type: Resource
database: InterPro
comment: CarbP_synth_ssu_N_sf

IPR029062
type: Resource
database: InterPro
comment: Class_I_gatase-like

IPR035686
type: Resource
database: InterPro
comment: CPSase_GATase1

IPR017926
type: Resource
database: InterPro
comment: GATASE

PTHR11405:SF4
type: Resource
database: PANTHER
comment: CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN
signature sequence match: PANTHER PTHR11405:SF4 match 1

PTHR11405
type: Resource
database: PANTHER
comment: CARBAMOYLTRANSFERASE FAMILY MEMBER
signature sequence match: PANTHER PTHR11405 match 1

PF00988
type: Resource
database: Pfam
comment: CPSase_sm_chain
signature sequence match: Pfam PF00988 match 1

PF00117
type: Resource
database: Pfam
comment: GATase
signature sequence match: Pfam PF00117 match 1

PR00097
type: Resource
database: PRINTS
comment: ANTSNTHASEII

PR00099
type: Resource
database: PRINTS
comment: CPSGATASE

PR00096
type: Resource
database: PRINTS
comment: GATASE

SM01097
type: Resource
database: SMART
comment: CPSase_sm_chain
signature sequence match: SMART SM01097 match 1

SSF52021
type: Resource
database: SUPFAM
comment: Carbamoyl phosphate synthetase, small subunit N-terminal domain
signature sequence match: SUPFAM SSF52021 match 1

SSF52317
type: Resource
database: SUPFAM
comment: Class I glutamine amidotransferase-like
signature sequence match: SUPFAM SSF52317 match 1

TIGR01368
type: Resource
database: TIGRFAMs
comment: CPSaseIIsmall
signature sequence match: TIGRFAMs TIGR01368 match 1

PS51273
type: Resource
database: PROSITE
comment: GATASE_TYPE_1
signature sequence match: PROSITE PS51273 match 1

SIP1E2AAD5826F81973
type: Structured Name
full name: Carbamoyl-phosphate synthase small chain
ec name: 6.3.5.5

SIP5D1781685ADDA81F
type: Structured Name
full name: Carbamoyl-phosphate synthetase glutamine chain

carA
type: Gene
locus name: FN0421

SIP320FD1D0975DA28A
type: Subunit Annotation
comment: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

SIP833ECB13AFF08053
type: Similarity Annotation
comment: Belongs to the CarA family.

PRO_0000112278
type: Chain Annotation
comment: Carbamoyl-phosphate synthase small chain
mass: 39448
range: 22861399146903342tt1tt358

22861399146903342tt1
type: Position
type: ExactPosition
position: 1
reference: Q8RG87-1

22861399146903342tt358
type: Position
type: ExactPosition
position: 358
reference: Q8RG87-1

SIPD94FC89FB29F3E62
type: Domain Extent Annotation
comment: Glutamine amidotransferase type-1
range: 22861399146903342tt172tt358

22861399146903342tt172
type: Position
type: ExactPosition
position: 172
reference: Q8RG87-1

SIP210684632962E05C
type: Region Annotation
comment: CPSase
range: 22861399146903342tt1tt168

22861399146903342tt168
type: Position
type: ExactPosition
position: 168
reference: Q8RG87-1

SIP794D33FA38C1D475
type: Active Site Annotation
comment: Nucleophile
range: 22861399146903342tt247tt247

22861399146903342tt247
type: Position
type: ExactPosition
position: 247
reference: Q8RG87-1

22861399146903342tt332
type: Position
type: ExactPosition
position: 332
reference: Q8RG87-1

22861399146903342tt334
type: Position
type: ExactPosition
position: 334
reference: Q8RG87-1

Q8RG87-1
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 39448
value: MYNRQLILEDGTVYKGYAFGADVENVGEVVFNTSMTGYQEILSDPSYNGQIVTLTYPLIGNYGINRDDFESMKPCIKGMVVKEVCATPSNFRSEKTLDEALKDFGIPGIYGIDTRALTRKLRSKGVVKGCLVSIDRNVDEVVAELKKTVLPTNQIEQVSSKSISPALGRGRRVVLVDLGMKIGIVRELVSRGCDVIVVPYNTTAEEVLRLEPDGVMLTNGPGDPEDAKESIEMIKGIINKVTIFGICMGHQLVSLACGAKTYKLKFGHRGGNHPVKNILTGRVDITSQNHGYAVDIDSLNDTDLELTHIAINDRSCEGVRHKKYPVFTVQFHPEAAAGPHDTSYLFDEFIKNIDNNMK

http://purl.uniprot.org/uniprot/Q8RG87#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q8RG87#attribution-10418227FB1BA43153D639116219F02D
manual: true
evidence: ECO_0000255
source: MF_01209

Q8RG86
type: Protein
reviewed: true
created: 2002-08-02
modified: 2023-05-03
version: 130
mnemonic: CARB_FUSNN
citation: http://purl.uniprot.org/citations/11889109
conflicting sequence: SIP1E84399C9CC65C60
recommended name: SIP70BCCA51962F43C3
alternative name: SIP628E9B800447372D
enzyme: http://purl.uniprot.org/enzyme/6.3.5.5
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIP92F7E35412066AD0
annotation: SIPE60900B4CFC30F8B
annotation: SIPF900B576F3B18E0E
annotation: SIPC52D0220677714A4
annotation: SIP4CBEBE171B21319A
annotation: SIPD92F4D9D63D25E0D
annotation: SIP150CA170D4D080B0
annotation: PRO_0000145007
annotation: SIP7E8BC787D29D3833
annotation: SIP74E652C64E11CA18
annotation: SIPA9EFA6E264A2F1D5
annotation: SIPB22B0D609CAC3A87
annotation: SIP7467501203C01C8E
annotation: SIP90431C487D91BCC0
annotation: SIP96DA522B783CB62A
annotation: SIP37B4ECE424D6DF5F
annotation: SIP383BBC2F72DE0403
annotation: SIPB3791DE4E9DD2092
annotation: SIP72F3EF6CA42ECD9A
annotation: SIP4A398F4F9D51F1D7
annotation: SIP4E3A3BAB2EA43409
annotation: SIP46403163E2D9347A
annotation: SIPDE8EFE10723D1C60
annotation: SIPB8C05E2BC1D21307
annotation: SIPE85995BC27FC7977
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/55
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/436
classified with: http://purl.uniprot.org/keywords/460
classified with: http://purl.uniprot.org/keywords/464
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/665
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/677
classified with: GO_0005737
classified with: GO_0005524
classified with: GO_0004088
classified with: GO_0046872
classified with: GO_0044205
classified with: GO_0006526
classified with: GO_0006541
sequence: Q8RG86-1
proteome: Chromosome

Q8RG86-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

EMBL AAL94625.1
comment: Different initiation.

COG0458
type: Resource
database: eggNOG
comment: Bacteria

cd01424
type: Resource
database: CDD
comment: MGS_CPS_II
signature sequence match: CDD cd01424 match 1

http://purl.uniprot.org/gene3d/3.30.1490.20
type: Resource
database: Gene3D
comment: ATP-grasp fold, A domain
signature sequence match: Gene3D 3.30.1490.20 match 1

http://purl.uniprot.org/gene3d/3.30.470.20
type: Resource
database: Gene3D
comment: ATP-grasp fold, B domain
signature sequence match: Gene3D 3.30.470.20 match 1
signature sequence match: Gene3D 3.30.470.20 match 2

http://purl.uniprot.org/gene3d/1.10.1030.10
type: Resource
database: Gene3D
comment: Carbamoyl-phosphate synthetase, large subunit oligomerisation domain
signature sequence match: Gene3D 1.10.1030.10 match 1

http://purl.uniprot.org/gene3d/3.40.50.1380
type: Resource
database: Gene3D
comment: Methylglyoxal synthase-like domain
signature sequence match: Gene3D 3.40.50.1380 match 1

MF 01210 A
type: Resource
database: HAMAP
comment: CPSase_L_chain_A
signature sequence match: HAMAP MF 01210 A match 1

MF 01210 B
type: Resource
database: HAMAP
comment: CPSase_L_chain_B
signature sequence match: HAMAP MF 01210 B match 1

IPR011761
type: Resource
database: InterPro
comment: ATP-grasp

IPR013815
type: Resource
database: InterPro
comment: ATP_grasp_subdomain_1

IPR006275
type: Resource
database: InterPro
comment: CarbamoylP_synth_lsu

IPR005480
type: Resource
database: InterPro
comment: CarbamoylP_synth_lsu_oligo

IPR036897
type: Resource
database: InterPro
comment: CarbamoylP_synth_lsu_oligo_sf

IPR005479
type: Resource
database: InterPro
comment: CbamoylP_synth_lsu-like_ATP-bd

IPR005483
type: Resource
database: InterPro
comment: CbamoylP_synth_lsu_CPSase_dom

IPR011607
type: Resource
database: InterPro
comment: MGS-like_dom

IPR036914
type: Resource
database: InterPro
comment: MGS-like_dom_sf

IPR033937
type: Resource
database: InterPro
comment: MGS_CPS_CarB

IPR016185
type: Resource
database: InterPro
comment: PreATP-grasp_dom_sf

PTHR11405:SF5
type: Resource
database: PANTHER
comment: CAD PROTEIN
signature sequence match: PANTHER PTHR11405:SF5 match 1

PF02786
type: Resource
database: Pfam
comment: CPSase_L_D2
signature sequence match: Pfam PF02786 match 1
signature sequence match: Pfam PF02786 match 2

PF02787
type: Resource
database: Pfam
comment: CPSase_L_D3
signature sequence match: Pfam PF02787 match 1

PF02142
type: Resource
database: Pfam
comment: MGS
signature sequence match: Pfam PF02142 match 1

PR00098
type: Resource
database: PRINTS
comment: CPSASE

SM01096
type: Resource
database: SMART
comment: CPSase_L_D3
signature sequence match: SMART SM01096 match 1

SM00851
type: Resource
database: SMART
comment: MGS
signature sequence match: SMART SM00851 match 1

SSF48108
type: Resource
database: SUPFAM
comment: Carbamoyl phosphate synthetase, large subunit connection domain
signature sequence match: SUPFAM SSF48108 match 1

SSF56059
type: Resource
database: SUPFAM
comment: Glutathione synthetase ATP-binding domain-like
signature sequence match: SUPFAM SSF56059 match 1
signature sequence match: SUPFAM SSF56059 match 2

SSF52335
type: Resource
database: SUPFAM
comment: Methylglyoxal synthase-like
signature sequence match: SUPFAM SSF52335 match 1

SSF52440
type: Resource
database: SUPFAM
comment: PreATP-grasp domain
signature sequence match: SUPFAM SSF52440 match 1
signature sequence match: SUPFAM SSF52440 match 2

TIGR01369
type: Resource
database: TIGRFAMs
comment: CPSaseII_lrg
signature sequence match: TIGRFAMs TIGR01369 match 1

PS50975
type: Resource
database: PROSITE
comment: ATP_GRASP
signature sequence match: PROSITE PS50975 match 1
signature sequence match: PROSITE PS50975 match 2

PS00866
type: Resource
database: PROSITE
comment: CPSASE_1
signature sequence match: PROSITE PS00866 match 1
signature sequence match: PROSITE PS00866 match 2

PS00867
type: Resource
database: PROSITE
comment: CPSASE_2
signature sequence match: PROSITE PS00867 match 1
signature sequence match: PROSITE PS00867 match 2

PS51855
type: Resource
database: PROSITE
comment: MGS
signature sequence match: PROSITE PS51855 match 1

SIP70BCCA51962F43C3
type: Structured Name
full name: Carbamoyl-phosphate synthase large chain
ec name: 6.3.5.5

SIP628E9B800447372D
type: Structured Name
full name: Carbamoyl-phosphate synthetase ammonia chain

carB
type: Gene
locus name: FN0422

SIPE60900B4CFC30F8B
type: Cofactor Annotation
comment: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
cofactor: CHEBI_18420
cofactor: CHEBI_29035

SIP4CBEBE171B21319A
type: Subunit Annotation
comment: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

SIPD92F4D9D63D25E0D
type: Similarity Annotation
comment: Belongs to the CarB family.

PRO_0000145007
type: Chain Annotation
comment: Carbamoyl-phosphate synthase large chain
mass: 117452
range: 22861399146903086tt1tt1058

22861399146903086tt1
type: Position
type: ExactPosition
position: 1
reference: Q8RG86-1

22861399146903086tt1058
type: Position
type: ExactPosition
position: 1058
reference: Q8RG86-1

SIP7E8BC787D29D3833
type: Domain Extent Annotation
comment: ATP-grasp 1
range: 22861399146903086tt133tt327

22861399146903086tt133
type: Position
type: ExactPosition
position: 133
reference: Q8RG86-1

22861399146903086tt327
type: Position
type: ExactPosition
position: 327
reference: Q8RG86-1

SIP74E652C64E11CA18
type: Domain Extent Annotation
comment: ATP-grasp 2
range: 22861399146903086tt671tt861

22861399146903086tt671
type: Position
type: ExactPosition
position: 671
reference: Q8RG86-1

22861399146903086tt861
type: Position
type: ExactPosition
position: 861
reference: Q8RG86-1

SIPA9EFA6E264A2F1D5
type: Domain Extent Annotation
comment: MGS-like
range: 22861399146903086tt930tt1058

22861399146903086tt930
type: Position
type: ExactPosition
position: 930
reference: Q8RG86-1

SIPB22B0D609CAC3A87
type: Region Annotation
comment: Carboxyphosphate synthetic domain
range: 22861399146903086tt1tt401

22861399146903086tt401
type: Position
type: ExactPosition
position: 401
reference: Q8RG86-1

SIP7467501203C01C8E
type: Region Annotation
comment: Oligomerization domain
range: 22861399146903086tt402tt546

22861399146903086tt402
type: Position
type: ExactPosition
position: 402
reference: Q8RG86-1

22861399146903086tt546
type: Position
type: ExactPosition
position: 546
reference: Q8RG86-1

SIP90431C487D91BCC0
type: Region Annotation
comment: Carbamoyl phosphate synthetic domain
range: 22861399146903086tt547tt929

22861399146903086tt547
type: Position
type: ExactPosition
position: 547
reference: Q8RG86-1

22861399146903086tt929
type: Position
type: ExactPosition
position: 929
reference: Q8RG86-1

SIP96DA522B783CB62A
type: Region Annotation
comment: Allosteric domain
range: 22861399146903086tt930tt1058

22861399146903086tt159
type: Position
type: ExactPosition
position: 159
reference: Q8RG86-1

22861399146903086tt216
type: Position
type: ExactPosition
position: 216
reference: Q8RG86-1

22861399146903086tt284
type: Position
type: ExactPosition
position: 284
reference: Q8RG86-1

22861399146903086tt298
type: Position
type: ExactPosition
position: 298
reference: Q8RG86-1

22861399146903086tt300
type: Position
type: ExactPosition
position: 300
reference: Q8RG86-1

22861399146903086tt697
type: Position
type: ExactPosition
position: 697
reference: Q8RG86-1

22861399146903086tt754
type: Position
type: ExactPosition
position: 754
reference: Q8RG86-1

22861399146903086tt820
type: Position
type: ExactPosition
position: 820
reference: Q8RG86-1

22861399146903086tt832
type: Position
type: ExactPosition
position: 832
reference: Q8RG86-1

22861399146903086tt834
type: Position
type: ExactPosition
position: 834
reference: Q8RG86-1

1
subclass of: CHEBI_18420

2
subclass of: CHEBI_18420

3
subclass of: CHEBI_18420

4
subclass of: CHEBI_18420

Q8RG86-1
type: Simple Sequence
modified: 2002-08-02
version: 2
mass: 117452
value: MPKRKDIKTILVIGSGPIIIGQAAEFDYAGTQACLSLREEGYEVILVNSNPATIMTDKEIADKVYIEPLTVEFLSKIIRKEKPDALLPTLGGQVALNLAVSLHESGILDECGVEILGTKLTSIKQAEDRELFRDLMNELNEPVPDSAIVHTLEEAENFVKEIDYPVIVRPAFTMGGTGGGICYNEEDLHEIVPNGLNYSPVHQCLLEKSIAGYKEIEYEVMRDSNDTAIVVCNMENIDPVGIHTGDSIVVAPSQTLTDREHHMLRDVSLKIIRALKIEGGCNVQIALDPNSFKYYIIEVNPRVSRSSALASKATGYPIAKIAAKIAVGMTLDEIINPVTKSSYACFEPAIDYVVTKIPRFPFDKFGDGDRYLGTQMKATGEVMAIGRTLEESLLKAIRSLEYGVHHLGLPNGEEFSLEKIIKRIKLAGDERLFFIGEALRRDVSIEEIHEYTKIDLFFLNKMKNIIDLEHLLKDNKGNIELLRKVKTFGFSDRVIAHRWEMTEPEITELRHKHNIRPVYKMVDTCAAEFDSNTPYFYSTYEFENESTRSDKEKIVVLGSGPIRIGQGIEFDYATVHAIMAIKKLGYEAIVINNNPETVSTDFSISDKLYFEPLTQEDVMEILDLEKPLGVVVQFGGQTAINLADKLVKNGIQILGSSLDSIDTAEDRDRFEKLLIGLKIPQPLGKTAFDVETALKNANEIGYPVLVRPSYVLGGRAMEIVYNDEDLTKYMEKAVHINPDHPVLIDRYLIGKEIEVDAISDGENTFIPGIMEHIERAGVHSGDSISIYPPQSLSEKEIETLIDYTKKLASGLEVKGLINIQYVVSKGEIYVLEVNPRASRTVPFLSKVTGVPVANIAMQCILGKKLKDLGFTKDIADIGNFVSVKVPVFSFQKLKNVDTTLGPEMKSTGEVIGTDVNLQKALYKGLTAAGIKIKDYGRVLFTIDDKNKEAALNLAKGFSDVGFSILTTEGTGIYFEEYGLKVKKVGKIDNSDYSVLDAIQNGDVDIVINTTTKGKSSEKDGFRIRRKATEYGVICFTSLDTANALLRVIESMSFRVQTL

http://purl.uniprot.org/uniprot/Q8RG86#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q8RG86#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/Q8RG86#attribution-CA6C1FA7B5F62B01D08D95E25A4BBCA0
manual: true
evidence: ECO_0000255
source: MF_01210

http://purl.uniprot.org/uniprot/Q8RG86#attribution-5EAC2F7D271A79B0C924FB087C595440
manual: true
evidence: ECO_0000255
source: PRU01202

http://purl.uniprot.org/uniprot/Q8RG86#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

Q8RED1
type: Protein
reviewed: true
created: 2012-05-16
modified: 2023-05-03
version: 92
mnemonic: CAS1_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIPFE44F79B9BBE8A3E
enzyme: http://purl.uniprot.org/enzyme/3.1.-.-
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIPC66457AAEAAAEA28
annotation: SIPACF034FF7A20AB0A
annotation: SIP6E8EDDF9C4CB35AD
annotation: SIP8998B31D7EC31E7A
annotation: PRO_0000417077
annotation: SIP7A6A7F5606A63B11
annotation: SIP7CAB8D4FAC6DA41E
annotation: SIPF642092241C4D7F4
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/51
classified with: http://purl.uniprot.org/keywords/238
classified with: http://purl.uniprot.org/keywords/255
classified with: http://purl.uniprot.org/keywords/460
classified with: http://purl.uniprot.org/keywords/464
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0003677
classified with: GO_0004520
classified with: GO_0046872
classified with: GO_0051607
classified with: GO_0043571
sequence: Q8RED1-1
proteome: Chromosome

Q8RED1-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG1518
type: Resource
database: eggNOG
comment: Bacteria

cd09722
type: Resource
database: CDD
comment: Cas1_I-B
signature sequence match: CDD cd09722 match 1

http://purl.uniprot.org/gene3d/1.20.120.920
type: Resource
database: Gene3D
comment: CRISPR-associated endonuclease Cas1, C-terminal domain
signature sequence match: Gene3D 1.20.120.920 match 1

http://purl.uniprot.org/gene3d/3.100.10.20
type: Resource
database: Gene3D
comment: CRISPR-associated endonuclease Cas1, N-terminal domain
signature sequence match: Gene3D 3.100.10.20 match 1

MF_01470
type: Resource
database: HAMAP
comment: Cas1
signature sequence match: HAMAP MF 01470 match 1

IPR002729
type: Resource
database: InterPro
comment: CRISPR-assoc_Cas1

IPR042206
type: Resource
database: InterPro
comment: CRISPR-assoc_Cas1_C

IPR019858
type: Resource
database: InterPro
comment: CRISPR-assoc_Cas1_HMARI/TNEAP

IPR042211
type: Resource
database: InterPro
comment: CRISPR-assoc_Cas1_N

PTHR43219
type: Resource
database: PANTHER
comment: CRISPR-ASSOCIATED ENDONUCLEASE CAS1
signature sequence match: PANTHER PTHR43219 match 1

PTHR43219:SF1
type: Resource
database: PANTHER
comment: CRISPR-ASSOCIATED ENDONUCLEASE CAS1
signature sequence match: PANTHER PTHR43219:SF1 match 1

PF01867
type: Resource
database: Pfam
comment: Cas_Cas1
signature sequence match: Pfam PF01867 match 1

TIGR00287
type: Resource
database: TIGRFAMs
comment: cas1
signature sequence match: TIGRFAMs TIGR00287 match 1

TIGR03641
type: Resource
database: TIGRFAMs
comment: cas1_HMARI
signature sequence match: TIGRFAMs TIGR03641 match 1

SIPFE44F79B9BBE8A3E
type: Structured Name
full name: CRISPR-associated endonuclease Cas1
ec name: 3.1.-.-

cas1
type: Gene
locus name: FN1177

SIPC66457AAEAAAEA28
type: Function Annotation
comment: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.

SIP6E8EDDF9C4CB35AD
type: Subunit Annotation
comment: Homodimer, forms a heterotetramer with a Cas2 homodimer.

SIP8998B31D7EC31E7A
type: Similarity Annotation
comment: Belongs to the CRISPR-associated endonuclease Cas1 family.

PRO_0000417077
type: Chain Annotation
comment: CRISPR-associated endonuclease Cas1
mass: 40819
range: 22861399114133806tt1tt338

22861399114133806tt1
type: Position
type: ExactPosition
position: 1
reference: Q8RED1-1

22861399114133806tt338
type: Position
type: ExactPosition
position: 338
reference: Q8RED1-1

22861399114133806tt165
type: Position
type: ExactPosition
position: 165
reference: Q8RED1-1

22861399114133806tt230
type: Position
type: ExactPosition
position: 230
reference: Q8RED1-1

22861399114133806tt245
type: Position
type: ExactPosition
position: 245
reference: Q8RED1-1

Q8RED1-1
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 40819
value: MFCIGGVNMKRSFFLYSNGTLKRKDNTITFINEKDEKRDIPIEMVDDFYVMSEMNFNTKFINYISQFGIPIHFFNYYTFYTGSFYPREMNISGQLLVKQVEHYTNEQKRVEIAREFIEGASFNIYRNLRYYNGRGKDLKLYMDQIEELRKHLKEVNNVEELMGYEGNIRKIYYEAWNIIVNQEIDFEKRVKNPPDNMINSLISFVNTLFYTKVLGEIYKTQLNPTVSYLHQPSTRRFSLSLDISEVFKPLIVDRLIFSLLNKNQITEKSFVKDFEYLRLKEDVSKLIVQEFEDRLKQIITHKDLNRKISYQYLVRLECYKLIKHLLGEKKYKSFQMWW

http://purl.uniprot.org/uniprot/Q8RED1#attribution-1E5D5B72DE6977837297A311880B82C9
manual: true
evidence: ECO_0000255
source: MF_01470

Q8RED2
type: Protein
reviewed: true
created: 2012-06-13
modified: 2023-05-03
version: 87
mnemonic: CAS2_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIP58203E9ECEDC6ACB
enzyme: http://purl.uniprot.org/enzyme/3.1.-.-
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIP4CC5BD0AE6E1B58B
annotation: SIPDF814827464FAD55
annotation: SIP919E558C043C09B6
annotation: SIPCA965A8BECD60525
annotation: PRO_0000417714
annotation: SIP913ADE94F85E7C45
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/51
classified with: http://purl.uniprot.org/keywords/255
classified with: http://purl.uniprot.org/keywords/460
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0046872
classified with: GO_0004521
classified with: GO_0051607
classified with: GO_0043571
sequence: MKRNINLFKCGGDKMYVVVVYDISLDEKGSRNWRKIFGICKRYLHHIQNSVFEGELSEVDIQRLKYEVSKYIRDDLDSFIIFKSRNERWMEKEMLGLQEDKTDNFL
proteome: Chromosome

Q8RED2-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG1343
type: Resource
database: eggNOG
comment: Bacteria

cd09725
type: Resource
database: CDD
comment: Cas2_I_II_III
signature sequence match: CDD cd09725 match 1

MF_01471
type: Resource
database: HAMAP
comment: Cas2
signature sequence match: HAMAP MF 01471 match 1

IPR021127
type: Resource
database: InterPro
comment: CRISPR_associated_Cas2

IPR019199
type: Resource
database: InterPro
comment: Virulence_VapD/CRISPR_Cas2

PTHR34405
type: Resource
database: PANTHER
comment: CRISPR-ASSOCIATED ENDORIBONUCLEASE CAS2
signature sequence match: PANTHER PTHR34405 match 1

PTHR34405:SF1
type: Resource
database: PANTHER
comment: CRISPR-ASSOCIATED ENDORIBONUCLEASE CAS2
signature sequence match: PANTHER PTHR34405:SF1 match 1

PF09827
type: Resource
database: Pfam
comment: CRISPR_Cas2
signature sequence match: Pfam PF09827 match 1

SSF143430
type: Resource
database: SUPFAM
comment: TTP0101/SSO1404-like
signature sequence match: SUPFAM SSF143430 match 1

TIGR01573
type: Resource
database: TIGRFAMs
comment: cas2
signature sequence match: TIGRFAMs TIGR01573 match 1

SIP58203E9ECEDC6ACB
type: Structured Name
full name: CRISPR-associated endoribonuclease Cas2
ec name: 3.1.-.-

cas2
type: Gene
locus name: FN1176

SIP4CC5BD0AE6E1B58B
type: Function Annotation
comment: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.

SIP919E558C043C09B6
type: Subunit Annotation
comment: Homodimer, forms a heterotetramer with a Cas1 homodimer.

SIPCA965A8BECD60525
type: Similarity Annotation
comment: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.

PRO_0000417714
type: Chain Annotation
comment: CRISPR-associated endoribonuclease Cas2
mass: 12805
range: 22861399114134062tt1tt106

22861399114134062tt1
type: Position
type: ExactPosition
position: 1
reference: MKRNINLFKCGGDKMYVVVVYDISLDEKGSRNWRKIFGICKRYLHHIQNSVFEGELSEVDIQRLKYEVSKYIRDDLDSFIIFKSRNERWMEKEMLGLQEDKTDNFL

22861399114134062tt106
type: Position
type: ExactPosition
position: 106
reference: MKRNINLFKCGGDKMYVVVVYDISLDEKGSRNWRKIFGICKRYLHHIQNSVFEGELSEVDIQRLKYEVSKYIRDDLDSFIIFKSRNERWMEKEMLGLQEDKTDNFL

22861399114134062tt22
type: Position
type: ExactPosition
position: 22
reference: MKRNINLFKCGGDKMYVVVVYDISLDEKGSRNWRKIFGICKRYLHHIQNSVFEGELSEVDIQRLKYEVSKYIRDDLDSFIIFKSRNERWMEKEMLGLQEDKTDNFL

SIP3C9371C25618D0A6
subclass of: CHEBI_18420
comment: catalytic

MKRNINLFKCGGDKMYVVVVYDISLDEKGSRNWRKIFGICKRYLHHIQNSVFEGELSEVDIQRLKYEVSKYIRDDLDSFIIFKSRNERWMEKEMLGLQEDKTDNFL
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 12805

http://purl.uniprot.org/uniprot/Q8RED2#attribution-7C5673A0680FCFC8F90B5740087391F4
manual: true
evidence: ECO_0000255
source: MF_01471

Q8R659
type: Protein
reviewed: true
created: 2008-02-05
modified: 2023-02-22
version: 102
mnemonic: CBIA_FUSNN
old mnemonic: COBB_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIP9443CA79431E1C67
alternative name: SIP0334C7BEA9B7505F
enzyme: http://purl.uniprot.org/enzyme/6.3.5.11
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIP153C5657B67208D7
annotation: SIP26CD4C83C96A865E
annotation: SIPB82A7C3DFD20C22A
annotation: SIPA34E49B7E3FBE675
annotation: SIPC52F0C31FEEEED60
annotation: SIPD119273158517DD5
annotation: SIP6F5DC1C5CB13B5EE
annotation: PRO_1000057225
annotation: SIP882120B6AE89D62C
annotation: SIPEA1F21D2AAFE86D7
annotation: SIPE6210C92D0D164A3
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/169
classified with: http://purl.uniprot.org/keywords/315
classified with: http://purl.uniprot.org/keywords/436
classified with: http://purl.uniprot.org/keywords/460
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005524
classified with: GO_0042242
classified with: GO_0009236
classified with: GO_0006541
sequence: Q8R659-1
proteome: Chromosome

Q8R659-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG1797
type: Resource
database: eggNOG
comment: Bacteria

cd05388
type: Resource
database: CDD
comment: CobB_N
signature sequence match: CDD cd05388 match 1

cd03130
type: Resource
database: CDD
comment: GATase1_CobB
signature sequence match: CDD cd03130 match 1

MF_00027
type: Resource
database: HAMAP
comment: CobB_CbiA
signature sequence match: HAMAP MF 00027 match 1

IPR004484
type: Resource
database: InterPro
comment: CbiA_synth

IPR011698
type: Resource
database: InterPro
comment: GATase_3

PTHR43873
type: Resource
database: PANTHER
comment: COBYRINATE A,C-DIAMIDE SYNTHASE
signature sequence match: PANTHER PTHR43873 match 1

PTHR43873:SF1
type: Resource
database: PANTHER
comment: COBYRINATE A,C-DIAMIDE SYNTHASE
signature sequence match: PANTHER PTHR43873:SF1 match 1

PF07685
type: Resource
database: Pfam
comment: GATase_3
signature sequence match: Pfam PF07685 match 1

TIGR00379
type: Resource
database: TIGRFAMs
comment: cobB
signature sequence match: TIGRFAMs TIGR00379 match 1

PS51274
type: Resource
database: PROSITE
comment: GATASE_COBBQ
signature sequence match: PROSITE PS51274 match 1

SIP9443CA79431E1C67
type: Structured Name
full name: Cobyrinate a,c-diamide synthase
ec name: 6.3.5.11

SIP0334C7BEA9B7505F
type: Structured Name
full name: Cobyrinic acid a,c-diamide synthetase

cbiA
type: Gene
locus name: FN0972

SIP153C5657B67208D7
type: Function Annotation
comment: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.

SIPC52F0C31FEEEED60
type: Domain Annotation
comment: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.

SIPD119273158517DD5
type: Annotation
comment: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

SIP6F5DC1C5CB13B5EE
type: Similarity Annotation
comment: Belongs to the CobB/CbiA family.

PRO_1000057225
type: Chain Annotation
comment: Cobyrinate a,c-diamide synthase
mass: 50389
range: 22861398861494574tt1tt444

22861398861494574tt1
type: Position
type: ExactPosition
position: 1
reference: Q8R659-1

22861398861494574tt444
type: Position
type: ExactPosition
position: 444
reference: Q8R659-1

SIP882120B6AE89D62C
type: Domain Extent Annotation
comment: GATase cobBQ-type
range: 22861398861494574tt250tt438

22861398861494574tt250
type: Position
type: ExactPosition
position: 250
reference: Q8R659-1

22861398861494574tt438
type: Position
type: ExactPosition
position: 438
reference: Q8R659-1

SIPEA1F21D2AAFE86D7
type: Active Site Annotation
comment: Nucleophile
range: 22861398861494574tt332tt332

22861398861494574tt332
type: Position
type: ExactPosition
position: 332
reference: Q8R659-1

SIPE6210C92D0D164A3
type: Site Annotation
comment: Increases nucleophilicity of active site Cys
range: 22861398861494574tt430tt430

22861398861494574tt430
type: Position
type: ExactPosition
position: 430
reference: Q8R659-1

Q8R659-1
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 50389
value: MKAFMLAGVSSGIGKTTISMALMSVFNNVSPFKVGPDYIDPGFHEFITGNKSYNLDIFMMGEQGVKYSFYKHHKDISIIEGVMGLYDGMDNSLDNNSSAHIARFLGVPVILVLDGVGKSTSIAAQVLGYKMLDPRVNISGVIINKVSSAKTYAIFKEAIEKYTGVKCLGFVEKNDKLNISSQHLGLLQASEVEDLREKLSILKNLVLQNIDLKEIEKIASEQTRTFNENETEIEPPLYISYLKDRYVGKIIAIAQDRAFSFYYNDNIEFLEYMGFKVKYFSPLKDSKVPECDIIYLGGGYPENFAEELSNNKEMFNSIRKNYEQGKNILAECGGFMYLSNGIEQIEGKVYQMCGLVPCVVNMTNRLDISRFGYILINNKNDIEIARGHEFHYSKLKAVLEDTRKFKAVKKDGRTWECIFNEKNLYAGYPHIHFFGSYKFIEEVF

http://purl.uniprot.org/uniprot/Q8R659#attribution-E55F6965EEA6D0CF2162254ACAEEE969
manual: true
evidence: ECO_0000255
source: MF_00027

Q8REW8
type: Protein
reviewed: true
created: 2004-06-07
modified: 2023-02-22
version: 102
mnemonic: CBID_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIP67687FEB328560B8
alternative name: SIPF74281DAD219A3C5
enzyme: http://purl.uniprot.org/enzyme/2.1.1.195
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIPBBA7D9E75E140B09
annotation: SIP570586A0A30BAF4E
annotation: SIP0F13ABC7CABAAA0F
annotation: SIPE5249AB72B327D8A
annotation: PRO_0000141665
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/169
classified with: http://purl.uniprot.org/keywords/489
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/949
classified with: GO_0043780
classified with: GO_0009236
classified with: GO_0046140
classified with: GO_0032259
sequence: Q8REW8-1
proteome: Chromosome

Q8REW8-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG1903
type: Resource
database: eggNOG
comment: Bacteria

http://purl.uniprot.org/gene3d/3.30.2110.10
type: Resource
database: Gene3D
comment: CbiD-like
signature sequence match: Gene3D 3.30.2110.10 match 1

MF_00787
type: Resource
database: HAMAP
comment: CbiD
signature sequence match: HAMAP MF 00787 match 1

IPR002748
type: Resource
database: InterPro
comment: CbiD

IPR036074
type: Resource
database: InterPro
comment: CbiD_sf

PTHR35863
type: Resource
database: PANTHER
comment: COBALT-PRECORRIN-5B C(1)-METHYLTRANSFERASE
signature sequence match: PANTHER PTHR35863 match 1

PTHR35863:SF1
type: Resource
database: PANTHER
comment: COBALT-PRECORRIN-5B C(1)-METHYLTRANSFERASE
signature sequence match: PANTHER PTHR35863:SF1 match 1

PF01888
type: Resource
database: Pfam
comment: CbiD
signature sequence match: Pfam PF01888 match 1

PIRSF026782
type: Resource
database: PIRSF
comment: CbiD
signature sequence match: PIRSF PIRSF026782 match 1

SSF111342
type: Resource
database: SUPFAM
comment: CbiD-like
signature sequence match: SUPFAM SSF111342 match 1

TIGR00312
type: Resource
database: TIGRFAMs
comment: cbiD
signature sequence match: TIGRFAMs TIGR00312 match 1

SIP67687FEB328560B8
type: Structured Name
full name: Cobalt-precorrin-5B C(1)-methyltransferase
ec name: 2.1.1.195

SIPF74281DAD219A3C5
type: Structured Name
full name: Cobalt-precorrin-6A synthase

cbiD
type: Gene
locus name: FN0967

SIPBBA7D9E75E140B09
type: Function Annotation
comment: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

SIPE5249AB72B327D8A
type: Similarity Annotation
comment: Belongs to the CbiD family.

PRO_0000141665
type: Chain Annotation
comment: Cobalt-precorrin-5B C(1)-methyltransferase
mass: 41145
range: 22861399115380782tt1tt375

22861399115380782tt1
type: Position
type: ExactPosition
position: 1
reference: Q8REW8-1

22861399115380782tt375
type: Position
type: ExactPosition
position: 375
reference: Q8REW8-1

Q8REW8-1
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 41145
value: MEEKELKNGYTTGTCATAAVKVALEALIYGKKATEVDITTLNYTNLKIPVQKLRVRNNFASCAIQKYAGDDPDVTNGISICAKVQLVKELPKVDRGAYYDNCVIIGGRGVGFVTKKGLQIAVGKSAINPGPQKMITSVVNEILDGSDEKVIITIYVPEGRAKALKTYNPKMGVIGGISVLGTTGIVKAMSEDALKKSMFAELKVMREDKNRDWIIFAFGNYGERHCQKIGLDTEQLIIISNFVGFMIEAAVKLEFKKIIMLGHIAKAIKVAGGIFNTHSRVADGRMETMAACAFLVDEKPEIIRKILASNTIEEACDYIEKKEIYHLIANRVAFKMQEYARADIEVSAAIFSFKGETIGESDNYQRMVGECGAIK

http://purl.uniprot.org/uniprot/Q8REW8#attribution-1A412304ECD521A3E6CA697EFAD2EDB0
manual: true
evidence: ECO_0000255
source: MF_00787

D1AFI6
type: Protein
reviewed: true
created: 2011-07-27
modified: 2023-02-22
version: 61
mnemonic: CBIM_SEBTE
citation: SIPB54CFA62CFC8F6DB
recommended name: SIP6B6AEDE75AC7CA49
alternative name: SIP1CEA8C31B4DFE2DF
organism: http://purl.uniprot.org/taxonomy/526218
annotation: SIPD6D88579E27341F8
annotation: SIP2CEEE97EDE87D8E9
annotation: SIP16616F9D5C6C27B2
annotation: SIP87005689D462044A
annotation: SIPB6445C7BD4263A50
annotation: SIPDE9B94DCB0D394F3
annotation: PRO_5000535479
annotation: SIP17F866F43203A2BE
annotation: SIPC369AE2992EB56F2
annotation: SIP7A027E30D6407E76
annotation: SIP229A30E2497C5DD6
annotation: SIPFD4EBACEAFAE6A55
annotation: SIPEA0F840804C6E3DE
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/997
classified with: http://purl.uniprot.org/keywords/169
classified with: http://purl.uniprot.org/keywords/171
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/732
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0043190
classified with: GO_0015087
classified with: GO_0009236
sequence: D1AFI6-1
proteome: Chromosome

SIPB54CFA62CFC8F6DB
type: Submission Citation
title: The complete chromosome of Sebaldella termitidis ATCC 33386.
author: Lucas S.
author: Copeland A.
author: Lapidus A.
author: Glavina del Rio T.
author: Dalin E.
author: Tice H.
author: Bruce D.
author: Goodwin L.
author: Pitluck S.
author: Kyrpides N.
author: Mavromatis K.
author: Ivanova N.
author: Mikhailova N.
author: Sims D.
author: Meincke L.
author: Brettin T.
author: Detter J.C.
author: Han C.
author: Larimer F.
author: Land M.
author: Hauser L.
author: Markowitz V.
author: Cheng J.F.
author: Hugenholtz P.
author: Woyke T.
author: Wu D.
author: Eisen J.A.
group: US DOE Joint Genome Institute (JGI-PGF)
date: 2009-09
submitted to: EMBL/GenBank/DDBJ

D1AFI6-citation-SIPB54CFA62CFC8F6DB
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 33386 / NCTC 11300
type: Strain

COG0310
type: Resource
database: eggNOG
comment: Bacteria

MF_01462
type: Resource
database: HAMAP
comment: CbiM
signature sequence match: HAMAP MF 01462 match 1

IPR018024
type: Resource
database: InterPro
comment: CbiM

IPR002751
type: Resource
database: InterPro
comment: CbiM/NikMN

PTHR43627:SF1
type: Resource
database: PANTHER
comment: COBALT TRANSPORT PROTEIN CBIM
signature sequence match: PANTHER PTHR43627:SF1 match 1

PF01891
type: Resource
database: Pfam
comment: CbiM
signature sequence match: Pfam PF01891 match 1

TIGR00123
type: Resource
database: TIGRFAMs
comment: cbiM
signature sequence match: TIGRFAMs TIGR00123 match 1

SIP6B6AEDE75AC7CA49
type: Structured Name
full name: Cobalt transport protein CbiM

SIP1CEA8C31B4DFE2DF
type: Structured Name
full name: Energy-coupling factor transporter probable substrate-capture protein CbiM
short name: ECF transporter S component CbiM

cbiM
type: Gene
locus name: Sterm_1003

SIPD6D88579E27341F8
type: Function Annotation
comment: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

SIP16616F9D5C6C27B2
type: Subunit Annotation
comment: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.

SIPB6445C7BD4263A50
type: Similarity Annotation
comment: Belongs to the CbiM family.

19194454838162990tt1
type: Position
type: ExactPosition
position: 1
reference: D1AFI6-1

19194454838162990tt23
type: Position
type: ExactPosition
position: 23
reference: D1AFI6-1

PRO_5000535479
type: Chain Annotation
comment: Cobalt transport protein CbiM
mass: 22625
range: 19194454838162990tt24tt236

19194454838162990tt24
type: Position
type: ExactPosition
position: 24
reference: D1AFI6-1

19194454838162990tt236
type: Position
type: ExactPosition
position: 236
reference: D1AFI6-1

SIP17F866F43203A2BE
type: Transmembrane Annotation
comment: Helical
range: 19194454838162990tt32tt52

19194454838162990tt32
type: Position
type: ExactPosition
position: 32
reference: D1AFI6-1

19194454838162990tt52
type: Position
type: ExactPosition
position: 52
reference: D1AFI6-1

SIPC369AE2992EB56F2
type: Transmembrane Annotation
comment: Helical
range: 19194454838162990tt66tt86

19194454838162990tt66
type: Position
type: ExactPosition
position: 66
reference: D1AFI6-1

19194454838162990tt86
type: Position
type: ExactPosition
position: 86
reference: D1AFI6-1

SIP7A027E30D6407E76
type: Transmembrane Annotation
comment: Helical
range: 19194454838162990tt98tt118

19194454838162990tt98
type: Position
type: ExactPosition
position: 98
reference: D1AFI6-1

19194454838162990tt118
type: Position
type: ExactPosition
position: 118
reference: D1AFI6-1

SIP229A30E2497C5DD6
type: Transmembrane Annotation
comment: Helical
range: 19194454838162990tt120tt140

19194454838162990tt120
type: Position
type: ExactPosition
position: 120
reference: D1AFI6-1

19194454838162990tt140
type: Position
type: ExactPosition
position: 140
reference: D1AFI6-1

SIPFD4EBACEAFAE6A55
type: Transmembrane Annotation
comment: Helical
range: 19194454838162990tt159tt179

19194454838162990tt159
type: Position
type: ExactPosition
position: 159
reference: D1AFI6-1

19194454838162990tt179
type: Position
type: ExactPosition
position: 179
reference: D1AFI6-1

SIPEA0F840804C6E3DE
type: Transmembrane Annotation
comment: Helical
range: 19194454838162990tt196tt216

19194454838162990tt196
type: Position
type: ExactPosition
position: 196
reference: D1AFI6-1

19194454838162990tt216
type: Position
type: ExactPosition
position: 216
reference: D1AFI6-1

D1AFI6-1
type: Simple Sequence
modified: 2010-01-19
version: 1
precursor: true
mass: 25199
value: MKNKSRIYLIASAFLILSVSSYSMHIMEGYLPVKWAVFWFILCAPFWIYGLVKLQKEAKGNVEEKLTLALAGAFIFVLSALKIPSVTGSSSHPTGVGLSAILFGPFITSILGTIALIFQAVLLAHGGLTTLGANAFSMAVAGPLVSYGIYRLLKKKNKSLAVFLAASLGNLSTYVITSFQLALANPSADGGITASFVKFAMIFAVTQIPLAVIEGLLTNVVMNLLEKYNIKQGVKA

http://purl.uniprot.org/uniprot/D1AFI6#attribution-1C947B3BC0BDCE82BB59A95AA91BF25B
manual: true
evidence: ECO_0000255
source: MF_01462

Q8R5X6
type: Protein
reviewed: true
created: 2002-10-10
modified: 2023-05-03
version: 99
mnemonic: CH10_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIPFDB43817E50FCF12
alternative name: SIP2774763869FB9103
alternative name: SIP5D535EA69F0EC691
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIP805D634FBB355D5B
annotation: SIP0175B6DE6E851D64
annotation: SIPFB60493B27CC6648
annotation: SIPF3C71B268632F794
annotation: PRO_0000174756
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/143
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005737
classified with: GO_0005524
classified with: GO_0046872
classified with: GO_0044183
classified with: GO_0051087
classified with: GO_0051082
classified with: GO_0051085
sequence: MNIKPIGERVLLKPIKKEEKTKSGILLSSKSSNTDTQNQAEVIALGKGEKLEGIKVGDKVIFNKFSGNEIEDGDVKYLIVNAEDILAIIG
proteome: Chromosome

Q8R5X6-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG0234
type: Resource
database: eggNOG
comment: Bacteria

cd00320
type: Resource
database: CDD
comment: cpn10
signature sequence match: CDD cd00320 match 1

http://purl.uniprot.org/gene3d/2.30.33.40
type: Resource
database: Gene3D
comment: GroES chaperonin
signature sequence match: Gene3D 2.30.33.40 match 1

MF_00580
type: Resource
database: HAMAP
comment: CH10
signature sequence match: HAMAP MF 00580 match 1

IPR020818
type: Resource
database: InterPro
comment: Chaperonin_GroES

IPR037124
type: Resource
database: InterPro
comment: Chaperonin_GroES_sf

IPR018369
type: Resource
database: InterPro
comment: Chaprnonin_Cpn10_CS

IPR011032
type: Resource
database: InterPro
comment: GroES-like_sf

PTHR10772
type: Resource
database: PANTHER
comment: 10 KDA HEAT SHOCK PROTEIN
signature sequence match: PANTHER PTHR10772 match 1

PTHR10772:SF0
type: Resource
database: PANTHER
comment: 10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL
signature sequence match: PANTHER PTHR10772:SF0 match 1

PF00166
type: Resource
database: Pfam
comment: Cpn10
signature sequence match: Pfam PF00166 match 1

PR00297
type: Resource
database: PRINTS
comment: CHAPERONIN10

SM00883
type: Resource
database: SMART
comment: Cpn10
signature sequence match: SMART SM00883 match 1

SSF50129
type: Resource
database: SUPFAM
comment: GroES-like
signature sequence match: SUPFAM SSF50129 match 1

PS00681
type: Resource
database: PROSITE
comment: CHAPERONINS_CPN10
signature sequence match: PROSITE PS00681 match 1

SIPFDB43817E50FCF12
type: Structured Name
full name: Co-chaperonin GroES

SIP2774763869FB9103
type: Structured Name
full name: 10 kDa chaperonin

SIP5D535EA69F0EC691
type: Structured Name
full name: Chaperonin-10
short name: Cpn10

groES
type: Gene
alternative label: groS
locus name: FN0676

SIP805D634FBB355D5B
type: Function Annotation
comment: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

SIP0175B6DE6E851D64
type: Subunit Annotation
comment: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.

SIPF3C71B268632F794
type: Similarity Annotation
comment: Belongs to the GroES chaperonin family.

PRO_0000174756
type: Chain Annotation
comment: Co-chaperonin GroES
mass: 9783
range: 22861398847010350tt1tt90

22861398847010350tt1
type: Position
type: ExactPosition
position: 1
reference: MNIKPIGERVLLKPIKKEEKTKSGILLSSKSSNTDTQNQAEVIALGKGEKLEGIKVGDKVIFNKFSGNEIEDGDVKYLIVNAEDILAIIG

22861398847010350tt90
type: Position
type: ExactPosition
position: 90
reference: MNIKPIGERVLLKPIKKEEKTKSGILLSSKSSNTDTQNQAEVIALGKGEKLEGIKVGDKVIFNKFSGNEIEDGDVKYLIVNAEDILAIIG

MNIKPIGERVLLKPIKKEEKTKSGILLSSKSSNTDTQNQAEVIALGKGEKLEGIKVGDKVIFNKFSGNEIEDGDVKYLIVNAEDILAIIG
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 9783

http://purl.uniprot.org/uniprot/Q8R5X6#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q8R5X6#attribution-BE67A4551C804FD86CAC41C18705626C
manual: true
evidence: ECO_0000255
source: MF_00580

Q8GJ01
type: Protein
reviewed: true
created: 2003-04-11
modified: 2023-05-03
version: 77
mnemonic: CH10_FUSNP
citation: SIPFC59E45C17B842DE
recommended name: SIPFDB43817E50FCF12
alternative name: SIP2774763869FB9103
alternative name: SIP5D535EA69F0EC691
organism: http://purl.uniprot.org/taxonomy/76857
annotation: SIP75BF8CDAEDEB228A
annotation: SIP4F597BBB45EBDB99
annotation: SIP31770EEFF6DC6E89
annotation: SIP1A8C77016A00554C
annotation: PRO_0000174757
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/143
classified with: http://purl.uniprot.org/keywords/963
classified with: GO_0005737
classified with: GO_0005524
classified with: GO_0044183
sequence: MNIKPIGERVLLKPIKKEEKTKSGILLSSKSSNTDTKNEAEVVALGKGEKLEGIKVGDKVIFNKFSGNEIEDGDIKYLIVNADDILAVIE

SIPFC59E45C17B842DE
type: Submission Citation
title: Genes encoding heat shock proteins 10 and 60 from Fusobacterium nucleatum ATCC 10953.
author: Skar C.K.
author: Bolstad A.
author: Bakken V.
date: 2001-07
submitted to: EMBL/GenBank/DDBJ

Q8GJ01-citation-SIPFC59E45C17B842DE
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

ATCC 10953 / DSM 20482 / CCUG 9126 / JCM 12990 / NCTC 10562 / 555A
type: Strain

SIPFDB43817E50FCF12
type: Structured Name
full name: Co-chaperonin GroES

SIP2774763869FB9103
type: Structured Name
full name: 10 kDa chaperonin

SIP5D535EA69F0EC691
type: Structured Name
full name: Chaperonin-10
short name: Cpn10

groES
type: Gene
alternative label: groS
alternative label: hsp10

SIP75BF8CDAEDEB228A
type: Function Annotation
comment: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

SIP4F597BBB45EBDB99
type: Subunit Annotation
comment: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.

SIP1A8C77016A00554C
type: Similarity Annotation
comment: Belongs to the GroES chaperonin family.

PRO_0000174757
type: Chain Annotation
comment: Co-chaperonin GroES
mass: 9828
range: 22861351952068910tt1tt90

22861351952068910tt1
type: Position
type: ExactPosition
position: 1
reference: MNIKPIGERVLLKPIKKEEKTKSGILLSSKSSNTDTKNEAEVVALGKGEKLEGIKVGDKVIFNKFSGNEIEDGDIKYLIVNADDILAVIE

22861351952068910tt90
type: Position
type: ExactPosition
position: 90
reference: MNIKPIGERVLLKPIKKEEKTKSGILLSSKSSNTDTKNEAEVVALGKGEKLEGIKVGDKVIFNKFSGNEIEDGDIKYLIVNADDILAVIE

MNIKPIGERVLLKPIKKEEKTKSGILLSSKSSNTDTKNEAEVVALGKGEKLEGIKVGDKVIFNKFSGNEIEDGDIKYLIVNADDILAVIE
type: Simple Sequence
modified: 2003-03-01
version: 1
mass: 9828

http://purl.uniprot.org/uniprot/Q8GJ01#attribution-BE67A4551C804FD86CAC41C18705626C
manual: true
evidence: ECO_0000255
source: MF_00580

Q8R5X7
type: Protein
reviewed: true
created: 2002-11-25
modified: 2023-05-03
version: 112
mnemonic: CH60_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIPF255B4347D4E348A
alternative name: SIPE5C33196A30979CA
alternative name: SIPE325E657B082D974
enzyme: http://purl.uniprot.org/enzyme/5.6.1.7
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIP3DEDF853B382C72A
annotation: SIPF64272840944D98A
annotation: SIPB69D6F87A3405D24
annotation: SIP31B6806A9EE65A55
annotation: SIPED2F68BF3CBE99B8
annotation: PRO_0000063378
annotation: SIP5C4FE2EF07667B0C
annotation: SIP3CEA1073CB8E7D8C
annotation: SIPD502DEED40FC741D
annotation: SIPA62A4E07AAB24A5B
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/143
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/413
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_1990220
classified with: GO_0005524
classified with: GO_0140662
classified with: GO_0016853
classified with: GO_0051082
classified with: GO_0051085
classified with: GO_0042026
classified with: GO_0009408
sequence: Q8R5X7-1
proteome: Chromosome

Q8R5X7-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG0459
type: Resource
database: eggNOG
comment: Bacteria

cd03344
type: Resource
database: CDD
comment: GroEL
signature sequence match: CDD cd03344 match 1

http://purl.uniprot.org/gene3d/3.50.7.10
type: Resource
database: Gene3D
comment: GroEL
signature sequence match: Gene3D 3.50.7.10 match 1

http://purl.uniprot.org/gene3d/1.10.560.10
type: Resource
database: Gene3D
comment: GroEL-like equatorial domain
signature sequence match: Gene3D 1.10.560.10 match 1

http://purl.uniprot.org/gene3d/3.30.260.10
type: Resource
database: Gene3D
comment: TCP-1-like chaperonin intermediate domain
signature sequence match: Gene3D 3.30.260.10 match 1

MF_00600
type: Resource
database: HAMAP
comment: CH60
signature sequence match: HAMAP MF 00600 match 1

IPR018370
type: Resource
database: InterPro
comment: Chaperonin_Cpn60_CS

IPR001844
type: Resource
database: InterPro
comment: Cpn60/GroEL

IPR002423
type: Resource
database: InterPro
comment: Cpn60/GroEL/TCP-1

IPR027409
type: Resource
database: InterPro
comment: GroEL-like_apical_dom_sf

IPR027413
type: Resource
database: InterPro
comment: GROEL-like_equatorial_sf

IPR027410
type: Resource
database: InterPro
comment: TCP-1-like_intermed_sf

PTHR45633
type: Resource
database: PANTHER
comment: 60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL
signature sequence match: PANTHER PTHR45633 match 1

PTHR45633:SF3
type: Resource
database: PANTHER
comment: 60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL
signature sequence match: PANTHER PTHR45633:SF3 match 1

PF00118
type: Resource
database: Pfam
comment: Cpn60_TCP1
signature sequence match: Pfam PF00118 match 1

PR00298
type: Resource
database: PRINTS
comment: CHAPERONIN60

SSF52029
type: Resource
database: SUPFAM
comment: GroEL apical domain-like
signature sequence match: SUPFAM SSF52029 match 1

SSF48592
type: Resource
database: SUPFAM
comment: GroEL equatorial domain-like
signature sequence match: SUPFAM SSF48592 match 1

SSF54849
type: Resource
database: SUPFAM
comment: GroEL-intermediate domain like
signature sequence match: SUPFAM SSF54849 match 1

TIGR02348
type: Resource
database: TIGRFAMs
comment: GroEL
signature sequence match: TIGRFAMs TIGR02348 match 1

PS00296
type: Resource
database: PROSITE
comment: CHAPERONINS_CPN60
signature sequence match: PROSITE PS00296 match 1

SIPF255B4347D4E348A
type: Structured Name
full name: Chaperonin GroEL
ec name: 5.6.1.7

SIPE5C33196A30979CA
type: Structured Name
full name: 60 kDa chaperonin

SIPE325E657B082D974
type: Structured Name
full name: Chaperonin-60
short name: Cpn60

groEL
type: Gene
alternative label: groL
locus name: FN0675

SIP3DEDF853B382C72A
type: Function Annotation
comment: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

SIPB69D6F87A3405D24
type: Subunit Annotation
comment: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.

SIPED2F68BF3CBE99B8
type: Similarity Annotation
comment: Belongs to the chaperonin (HSP60) family.

PRO_0000063378
type: Chain Annotation
comment: Chaperonin GroEL
mass: 57548
range: 22861398847010606tt1tt539

22861398847010606tt1
type: Position
type: ExactPosition
position: 1
reference: Q8R5X7-1

22861398847010606tt539
type: Position
type: ExactPosition
position: 539
reference: Q8R5X7-1

22861398847010606tt29
type: Position
type: ExactPosition
position: 29
reference: Q8R5X7-1

22861398847010606tt32
type: Position
type: ExactPosition
position: 32
reference: Q8R5X7-1

22861398847010606tt86
type: Position
type: ExactPosition
position: 86
reference: Q8R5X7-1

22861398847010606tt90
type: Position
type: ExactPosition
position: 90
reference: Q8R5X7-1

22861398847010606tt413
type: Position
type: ExactPosition
position: 413
reference: Q8R5X7-1

22861398847010606tt492
type: Position
type: ExactPosition
position: 492
reference: Q8R5X7-1

Q8R5X7-1
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 57548
value: MAKIINFNDEARKKLEIGVNTLADAVKVTLGPRGRNVVLEKSYGAPLITNDGVTIAKEIELEDPFENMGAALVKEVAIKSNDVAGDGTTTATILAQAIVKEGLKMLSAGANPIFLKKGIELAAKEAVEVLKDKAKKIESNEEISQVASISAGDEEIGKLIAQAMAKVGETGVITVEEAKSLETTLEIVEGMQFDKGYVSPYMVTDSERMTAELDNPLILLTDKKISSMKELLPLLEQTVQMSKPVLIVADDIEGEALTTLVINKLRGTLNVVAVKAPAFGDRRKAILEDIAILTGGEVISEEKGMKLEEATIEQLGKAKTVKVTKDLTVIVDGGGQQKDISARVNSIKAQIAETTSDYDKEKLQERLAKLSGGVAVIKVGAATEVEMKDKKLRIEDALNATRAAVEEGIVAGGGTILLDIIESMKDFNETDEIAMGIEIVKRALEAPIKQIAENCGLNGGVVLEKVRMSPKGFGFDAKNEKYVNMIESGIIDPAKVTRAAIQNSTSVASLLLTTEVVIANKKEEEKAPMGAGGMMPGMM

http://purl.uniprot.org/uniprot/Q8R5X7#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q8R5X7#attribution-2F1A0E67B478851653C1AADDD6958B54
manual: true
evidence: ECO_0000255
source: MF_00600

Q8GJ00
type: Protein
reviewed: true
created: 2003-04-11
modified: 2023-02-22
version: 84
mnemonic: CH60_FUSNP
citation: SIPFC59E45C17B842DE
recommended name: SIPF255B4347D4E348A
alternative name: SIPE5C33196A30979CA
alternative name: SIPE325E657B082D974
enzyme: http://purl.uniprot.org/enzyme/5.6.1.7
organism: http://purl.uniprot.org/taxonomy/76857
annotation: SIP7CDBF83DDDFFA005
annotation: SIPCBF58644E5B9130E
annotation: SIP10339A10F397F6E1
annotation: SIPFA517D94A844F20F
annotation: SIP1C6ABB672C55DDE4
annotation: PRO_0000063379
annotation: SIP60F687A31CFD4A33
annotation: SIP23F0C7824F1CF87C
annotation: SIP8D6201F5915E930F
annotation: SIPCD8462C859279B29
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/143
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/413
classified with: GO_0005737
classified with: GO_0005524
classified with: GO_0140662
classified with: GO_0016853
classified with: GO_0051082
classified with: GO_0042026
sequence: Q8GJ00-1

Q8GJ00-citation-SIPFC59E45C17B842DE
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

ATCC 10953 / DSM 20482 / CCUG 9126 / JCM 12990 / NCTC 10562 / 555A
type: Strain

SIPF255B4347D4E348A
type: Structured Name
full name: Chaperonin GroEL
ec name: 5.6.1.7

SIPE5C33196A30979CA
type: Structured Name
full name: 60 kDa chaperonin

SIPE325E657B082D974
type: Structured Name
full name: Chaperonin-60
short name: Cpn60

groEL
type: Gene
alternative label: groL
alternative label: hsp60

SIP7CDBF83DDDFFA005
type: Function Annotation
comment: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

SIP10339A10F397F6E1
type: Subunit Annotation
comment: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.

SIP1C6ABB672C55DDE4
type: Similarity Annotation
comment: Belongs to the chaperonin (HSP60) family.

PRO_0000063379
type: Chain Annotation
comment: Chaperonin GroEL
mass: 57552
range: 22861351952068654tt1tt539

22861351952068654tt1
type: Position
type: ExactPosition
position: 1
reference: Q8GJ00-1

22861351952068654tt539
type: Position
type: ExactPosition
position: 539
reference: Q8GJ00-1

22861351952068654tt29
type: Position
type: ExactPosition
position: 29
reference: Q8GJ00-1

22861351952068654tt32
type: Position
type: ExactPosition
position: 32
reference: Q8GJ00-1

22861351952068654tt86
type: Position
type: ExactPosition
position: 86
reference: Q8GJ00-1

22861351952068654tt90
type: Position
type: ExactPosition
position: 90
reference: Q8GJ00-1

22861351952068654tt413
type: Position
type: ExactPosition
position: 413
reference: Q8GJ00-1

22861351952068654tt492
type: Position
type: ExactPosition
position: 492
reference: Q8GJ00-1

Q8GJ00-1
type: Simple Sequence
modified: 2003-03-01
version: 1
mass: 57552
value: MAKIINFNDEARKKLEIGVNTLADAVKVTLGPRGRNVVLEKSYGAPLITNDGVTIAKEIELEDPFENMGAALVKEVAIKSNDVAGDGTTTATILAQAIVKEGLKMLSAGANPIFLKKGIELAAKEAIDVLKDKAKKIESNEEISQVASISAGDEEIGKLIAQAMAKVGETGVITVEEAKSLETTLETVEGMQFDKGYVSPYMVTDSERMTAELDNPLILLTDKKISSMKELLPLLEQTVQMSKPVLIVADDIEGEALTTLVINKLRGTLNVVAVKAPAFGDRRKAILEDIAILTGGEVISEEKGMKLEEATIQQLGKAKTVKVTKDLTVIVDGGGEQKDISARVNSIKAQIEETTSDYDKEKLQERLAKLSGGVAVIKVGAATEVEMKDKKLRIEDALNATRAAVEEGIVAGGGTILLDIIESMKDFNETGEIAMGIEIVKRALEAPIKQIAENCGLNGGVVLEKVRMSPKGFGFDAKNEKYVNMIECGIIDPAKVTRAAIQNSTSVASLLLTTEVVIANKKEEEKAPMGAGGMMPGMM

http://purl.uniprot.org/uniprot/Q8GJ00#attribution-2F1A0E67B478851653C1AADDD6958B54
manual: true
evidence: ECO_0000255
source: MF_00600

Q8RHR9
type: Protein
reviewed: true
created: 2008-05-20
modified: 2023-02-22
version: 94
mnemonic: CINAL_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIP2C62ACE823117DDC
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIP89B8992D6180DC70
annotation: PRO_0000336501
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/1185
sequence: Q8RHR9-1
proteome: Chromosome

Q8RHR9-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG1058
type: Resource
database: eggNOG
comment: Bacteria

COG1546
type: Resource
database: eggNOG
comment: Bacteria

cd00885
type: Resource
database: CDD
comment: cinA
signature sequence match: CDD cd00885 match 1

http://purl.uniprot.org/gene3d/3.90.950.20
type: Resource
database: Gene3D
comment: CinA-like
signature sequence match: Gene3D 3.90.950.20 match 1

http://purl.uniprot.org/gene3d/3.40.980.10
type: Resource
database: Gene3D
comment: MoaB/Mog-like domain
signature sequence match: Gene3D 3.40.980.10 match 1

MF 00226 B
type: Resource
database: HAMAP
comment: CinA_B
signature sequence match: HAMAP MF 00226 B match 1

IPR036653
type: Resource
database: InterPro
comment: CinA-like_C

IPR008136
type: Resource
database: InterPro
comment: CinA_C

IPR041424
type: Resource
database: InterPro
comment: CinA_KH

IPR008135
type: Resource
database: InterPro
comment: Competence-induced_CinA

IPR036425
type: Resource
database: InterPro
comment: MoaB/Mog-like_dom_sf

IPR001453
type: Resource
database: InterPro
comment: MoaB/Mog_dom

PTHR13939
type: Resource
database: PANTHER
comment: NICOTINAMIDE-NUCLEOTIDE AMIDOHYDROLASE PNCC
signature sequence match: PANTHER PTHR13939 match 1

PTHR13939:SF0
type: Resource
database: PANTHER
comment: PROTEIN YDEJ
signature sequence match: PANTHER PTHR13939:SF0 match 1

PF02464
type: Resource
database: Pfam
comment: CinA
signature sequence match: Pfam PF02464 match 1

PF18146
type: Resource
database: Pfam
comment: CinA_KH
signature sequence match: Pfam PF18146 match 1

PF00994
type: Resource
database: Pfam
comment: MoCF_biosynth
signature sequence match: Pfam PF00994 match 1

PIRSF006728
type: Resource
database: PIRSF
comment: CinA
signature sequence match: PIRSF PIRSF006728 match 1

SM00852
type: Resource
database: SMART
comment: MoCF_biosynth
signature sequence match: SMART SM00852 match 1

SSF142433
type: Resource
database: SUPFAM
comment: CinA-like
signature sequence match: SUPFAM SSF142433 match 1

SSF53218
type: Resource
database: SUPFAM
comment: Molybdenum cofactor biosynthesis proteins
signature sequence match: SUPFAM SSF53218 match 1

TIGR00200
type: Resource
database: TIGRFAMs
comment: cinA_nterm
signature sequence match: TIGRFAMs TIGR00200 match 1

TIGR00199
type: Resource
database: TIGRFAMs
comment: PncC_domain
signature sequence match: TIGRFAMs TIGR00199 match 1

SIP2C62ACE823117DDC
type: Structured Name
full name: CinA-like protein

http://purl.uniprot.org/uniprot/Q8RHR9#gene-MD588FEED9666D45C0F7427FBBFF609D285
type: Gene
locus name: FN1929

SIP89B8992D6180DC70
type: Similarity Annotation
comment: Belongs to the CinA family.

PRO_0000336501
type: Chain Annotation
comment: CinA-like protein
mass: 45147
range: 22861399165385006tt1tt402

22861399165385006tt1
type: Position
type: ExactPosition
position: 1
reference: Q8RHR9-1

22861399165385006tt402
type: Position
type: ExactPosition
position: 402
reference: Q8RHR9-1

Q8RHR9-1
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 45147
value: MKAGIFLVGTELLNGATIDTNSIYIAEELNKYGIEIEFKMTVRDVMSEITKALTYAKKNVDLVILTGGLGPTDDDITKEAMAKFLKKKLVVDEKEKKELLKKYKAYKNPNKTNFKEVEKPEGAVSFKNDVGMAPAVYIDGMVAFPGFPNELKNMFPKFLKYYVKENNLKSQIYIKDIITYGIGESVLETTVKDLFTEGDIFYEFLVKDYGTLIRLQTKIENKKNVAKIVKKLYNRISEFIIGEDDDRIENTIYECLNLGEKPLTISTAESCTGGMVASKLIEVPGISENFIESIVSYSNEAKIKRLKVKKETLEKYGAVSEEVAREMLAGLKTDIGISTTGIAGPGGGTKDKPVGLVYIGIKVKNEVKVFKRELKGDRNKIRQRAMMHALYNLLKILSKKVR

http://purl.uniprot.org/uniprot/Q8RHR9#attribution-81AE8B0F74AEEFE043D3C73BD7958463
manual: true
evidence: ECO_0000255
source: MF_00226

Q8RDW6
type: Protein
reviewed: true
created: 2005-02-15
modified: 2022-08-03
version: 85
mnemonic: CITD_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIPBEEC68FA34777DED
alternative name: SIPAA9C7A4D677E628B
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIP5D56E07E7CD32C62
annotation: SIP4EEF5EFE68D17E40
annotation: SIP8882A989B251AFC8
annotation: SIP071F704287D61F44
annotation: PRO_0000214698
annotation: SIPF4199F66672BB311
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/597
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005737
sequence: MVLKTVGVAGTLESSDAMITVEPANQGGIVIDISSSVKRQFGRQIEETVLNTIKELGVENANVKVVDKGALNYALIARTKAAVYRAAESNDYKF
proteome: Chromosome

Q8RDW6-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG3052
type: Resource
database: eggNOG
comment: Bacteria

MF_00805
type: Resource
database: HAMAP
comment: CitD
signature sequence match: HAMAP MF 00805 match 1

IPR006495
type: Resource
database: InterPro
comment: CitD

IPR023439
type: Resource
database: InterPro
comment: Mal_deCO2ase/Cit_lyase_ACP

PF06857
type: Resource
database: Pfam
comment: ACP
signature sequence match: Pfam PF06857 match 1

PIRSF002736
type: Resource
database: PIRSF
comment: Citrt_lyas_gamma
signature sequence match: PIRSF PIRSF002736 match 1

TIGR01608
type: Resource
database: TIGRFAMs
comment: citD
signature sequence match: TIGRFAMs TIGR01608 match 1

SIPBEEC68FA34777DED
type: Structured Name
full name: Citrate lyase acyl carrier protein

SIPAA9C7A4D677E628B
type: Structured Name
full name: Citrate lyase gamma chain

citD
type: Gene
locus name: FN1378

SIP5D56E07E7CD32C62
type: Function Annotation
comment: Covalent carrier of the coenzyme of citrate lyase.

SIP4EEF5EFE68D17E40
type: Subunit Annotation
comment: Oligomer with a subunit composition of (alpha,beta,gamma)6.

SIP071F704287D61F44
type: Similarity Annotation
comment: Belongs to the CitD family.

PRO_0000214698
type: Chain Annotation
comment: Citrate lyase acyl carrier protein
mass: 10088
range: 22861399098603054tt1tt94

22861399098603054tt1
type: Position
type: ExactPosition
position: 1
reference: MVLKTVGVAGTLESSDAMITVEPANQGGIVIDISSSVKRQFGRQIEETVLNTIKELGVENANVKVVDKGALNYALIARTKAAVYRAAESNDYKF

22861399098603054tt94
type: Position
type: ExactPosition
position: 94
reference: MVLKTVGVAGTLESSDAMITVEPANQGGIVIDISSSVKRQFGRQIEETVLNTIKELGVENANVKVVDKGALNYALIARTKAAVYRAAESNDYKF

SIPF4199F66672BB311
type: Modified Residue Annotation
comment: O-(phosphoribosyl dephospho-coenzyme A)serine
range: 22861399098603054tt14tt14

22861399098603054tt14
type: Position
type: ExactPosition
position: 14
reference: MVLKTVGVAGTLESSDAMITVEPANQGGIVIDISSSVKRQFGRQIEETVLNTIKELGVENANVKVVDKGALNYALIARTKAAVYRAAESNDYKF

MVLKTVGVAGTLESSDAMITVEPANQGGIVIDISSSVKRQFGRQIEETVLNTIKELGVENANVKVVDKGALNYALIARTKAAVYRAAESNDYKF
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 10088

http://purl.uniprot.org/uniprot/Q8RDW6#attribution-E70FEB8EF59FE663852BA716AED9B012
manual: true
evidence: ECO_0000255
source: MF_00805

Q8RHQ8
type: Protein
reviewed: true
created: 2004-10-11
modified: 2023-05-03
version: 115
mnemonic: CLPB_FUSNN
citation: http://purl.uniprot.org/citations/11889109
conflicting sequence: SIP1308D637A32418C8
recommended name: SIP38C4ECF2E591A446
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIP880B6A492913E3B8
annotation: SIP7F1CE740ACA1417A
annotation: SIPA89811CA35728522
annotation: SIP2AB36481DE156599
annotation: SIP2B1949319078F81C
annotation: SIP61CB209FEA96306E
annotation: PRO_0000191123
annotation: SIP904B97B2EDF8B307
annotation: SIPF41F1F52B4A51A43
annotation: SIPA21EB6DBF9DC0CE4
annotation: SIP819B0552B36F31C8
annotation: SIP4C6564AB229B4AE9
annotation: SIP857E09A2E5EC9E07
annotation: SIP8C31B1BC11935A9D
annotation: SIP52CD2054EA951D8D
annotation: SIPD64819408DB246C6
annotation: SIP0BDE760471A1E721
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/143
classified with: http://purl.uniprot.org/keywords/175
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/677
classified with: http://purl.uniprot.org/keywords/346
classified with: GO_0005737
classified with: GO_0005524
classified with: GO_0016887
classified with: GO_0034605
classified with: GO_0042026
sequence: Q8RHQ8-1
proteome: Chromosome

Q8RHQ8-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

EMBL AAL94040.1
comment: Different initiation.

COG0542
type: Resource
database: eggNOG
comment: Bacteria

cd00009
type: Resource
database: CDD
comment: AAA
signature sequence match: CDD cd00009 match 1

cd19499
type: Resource
database: CDD
comment: RecA-like_ClpB_Hsp104-like
signature sequence match: CDD cd19499 match 1

http://purl.uniprot.org/gene3d/1.10.1780.10
type: Resource
database: Gene3D
comment: Clp, N-terminal domain
signature sequence match: Gene3D 1.10.1780.10 match 1

IPR003959
type: Resource
database: InterPro
comment: ATPase_AAA_core

IPR017730
type: Resource
database: InterPro
comment: Chaperonin_ClpB

IPR019489
type: Resource
database: InterPro
comment: Clp_ATPase_C

IPR036628
type: Resource
database: InterPro
comment: Clp_N_dom_sf

IPR004176
type: Resource
database: InterPro
comment: Clp_R_dom

IPR001270
type: Resource
database: InterPro
comment: ClpA/B

IPR018368
type: Resource
database: InterPro
comment: ClpA/B_CS1

IPR028299
type: Resource
database: InterPro
comment: ClpA/B_CS2

IPR041546
type: Resource
database: InterPro
comment: ClpA/ClpB_AAA_lid

PTHR11638
type: Resource
database: PANTHER
comment: ATP-DEPENDENT CLP PROTEASE
signature sequence match: PANTHER PTHR11638 match 1

PTHR11638:SF18
type: Resource
database: PANTHER
comment: HEAT SHOCK PROTEIN 104
signature sequence match: PANTHER PTHR11638:SF18 match 1

PF00004
type: Resource
database: Pfam
comment: AAA
signature sequence match: Pfam PF00004 match 1

PF07724
type: Resource
database: Pfam
comment: AAA_2
signature sequence match: Pfam PF07724 match 1

PF17871
type: Resource
database: Pfam
comment: AAA_lid_9
signature sequence match: Pfam PF17871 match 1

PF02861
type: Resource
database: Pfam
comment: Clp_N
signature sequence match: Pfam PF02861 match 1
signature sequence match: Pfam PF02861 match 2

PF10431
type: Resource
database: Pfam
comment: ClpB_D2-small
signature sequence match: Pfam PF10431 match 1

PR00300
type: Resource
database: PRINTS
comment: CLPPROTEASEA

SM01086
type: Resource
database: SMART
comment: ClpB_D2-small
signature sequence match: SMART SM01086 match 1

SSF81923
type: Resource
database: SUPFAM
comment: Double Clp-N motif
signature sequence match: SUPFAM SSF81923 match 1

TIGR03346
type: Resource
database: TIGRFAMs
comment: chaperone_ClpB
signature sequence match: TIGRFAMs TIGR03346 match 1

PS51903
type: Resource
database: PROSITE
comment: CLP_R
signature sequence match: PROSITE PS51903 match 1

PS00870
type: Resource
database: PROSITE
comment: CLPAB_1
signature sequence match: PROSITE PS00870 match 1

PS00871
type: Resource
database: PROSITE
comment: CLPAB_2
signature sequence match: PROSITE PS00871 match 1

SIP38C4ECF2E591A446
type: Structured Name
full name: Chaperone protein ClpB

clpB
type: Gene
locus name: FN1941

SIP880B6A492913E3B8
type: Function Annotation
comment: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).

SIP7F1CE740ACA1417A
type: Subunit Annotation
comment: Homohexamer. The oligomerization is ATP-dependent (By similarity).

SIP2AB36481DE156599
type: Domain Annotation
comment: The Clp repeat (R) domain probably functions as a substrate-discriminating domain, recruiting aggregated proteins to the ClpB hexamer and/or stabilizing bound proteins. The NBD2 domain is responsible for oligomerization, whereas the NBD1 domain stabilizes the hexamer probably in an ATP-dependent manner. The movement of the coiled-coil domain is essential for ClpB ability to rescue proteins from an aggregated state, probably by pulling apart large aggregated proteins, which are bound between the coiled-coils motifs of adjacent ClpB subunits in the functional hexamer (By similarity).

SIP2B1949319078F81C
type: Similarity Annotation
comment: Belongs to the ClpA/ClpB family.

PRO_0000191123
type: Chain Annotation
comment: Chaperone protein ClpB
mass: 97405
range: 22861399165319214tt1tt857

22861399165319214tt1
type: Position
type: ExactPosition
position: 1
reference: Q8RHQ8-1

22861399165319214tt857
type: Position
type: ExactPosition
position: 857
reference: Q8RHQ8-1

SIP904B97B2EDF8B307
type: Domain Extent Annotation
comment: Clp R
range: 22861399165319214tt3tt144

22861399165319214tt3
type: Position
type: ExactPosition
position: 3
reference: Q8RHQ8-1

22861399165319214tt144
type: Position
type: ExactPosition
position: 144
reference: Q8RHQ8-1

SIPF41F1F52B4A51A43
type: Region Annotation
comment: Repeat 1
range: 22861399165319214tt6tt71

22861399165319214tt6
type: Position
type: ExactPosition
position: 6
reference: Q8RHQ8-1

22861399165319214tt71
type: Position
type: ExactPosition
position: 71
reference: Q8RHQ8-1

SIPA21EB6DBF9DC0CE4
type: Region Annotation
comment: Repeat 2
range: 22861399165319214tt85tt144

22861399165319214tt85
type: Position
type: ExactPosition
position: 85
reference: Q8RHQ8-1

SIP819B0552B36F31C8
type: Region Annotation
comment: NBD1
range: 22861399165319214tt157tt338

22861399165319214tt157
type: Position
type: ExactPosition
position: 157
reference: Q8RHQ8-1

22861399165319214tt338
type: Position
type: ExactPosition
position: 338
reference: Q8RHQ8-1

SIP4C6564AB229B4AE9
type: Region Annotation
comment: Linker
range: 22861399165319214tt339tt546

22861399165319214tt339
type: Position
type: ExactPosition
position: 339
reference: Q8RHQ8-1

22861399165319214tt546
type: Position
type: ExactPosition
position: 546
reference: Q8RHQ8-1

SIP857E09A2E5EC9E07
type: Region Annotation
comment: NBD2
range: 22861399165319214tt556tt764

22861399165319214tt556
type: Position
type: ExactPosition
position: 556
reference: Q8RHQ8-1

22861399165319214tt764
type: Position
type: ExactPosition
position: 764
reference: Q8RHQ8-1

SIP8C31B1BC11935A9D
type: Region Annotation
comment: C-terminal
range: 22861399165319214tt765tt857

22861399165319214tt765
type: Position
type: ExactPosition
position: 765
reference: Q8RHQ8-1

22861399165319214tt389
type: Position
type: ExactPosition
position: 389
reference: Q8RHQ8-1

22861399165319214tt523
type: Position
type: ExactPosition
position: 523
reference: Q8RHQ8-1

22861399165319214tt204
type: Position
type: ExactPosition
position: 204
reference: Q8RHQ8-1

22861399165319214tt211
type: Position
type: ExactPosition
position: 211
reference: Q8RHQ8-1

22861399165319214tt606
type: Position
type: ExactPosition
position: 606
reference: Q8RHQ8-1

22861399165319214tt613
type: Position
type: ExactPosition
position: 613
reference: Q8RHQ8-1

1
subclass of: CHEBI_30616

2
subclass of: CHEBI_30616

Q8RHQ8-1
type: Simple Sequence
modified: 2004-10-11
version: 2
mass: 97405
value: MNPNQFTENTISAINLAVDISKGNMQQSIKPEALALGLLMQNNGLIPRVIEKMGLNLQYIISELEKEMNNYPKVEVKVSNENISLDQKTNSILNRAEKIMNEMEDSFLSVEHIFKAMIEEMPIFKRFGISLEKYMEVLMNIRGNRKVDNQNPEATYEVLEKYAKDLVELAREGKIDPIIGRDSEIRRAIQIISRRTKNDPILIGEPGVGKTAIVEGLAQRILNGDVPESLKNKKIFSLDMGALVAGAKYKGEFEERMKGVLKEVEESNGNIILFIDEIHTIVGAGKGEGSLDAGNMLKPMLARGELRVIGATTIDEYRKYIEKDPALERRFQTILVNEPNVDDTISILRGLKDKFETYHGVRITDTAIVEAATLSQRYISDRKLPDKAIDLIDEAAAMIRTEIDSMPEELDQLTRKALQLEIEIKALEKETDDASKERLKVIEKELAELNEEKKVLTSKWELEKEDISKIKNIKREIENVKLEMEKAEREYDLTKLSELKYGKLATLEKELQEQQNKVDKDGKENSLLKQEVTADEIADIVSRWTGIPVSKLTETKKEKMLHLEDHIKERVKGQDEAIKSVADTMLRSVAGLKDPNRPMGSFIFLGPTGVGKTYLAKTLAYNLFDSEDNVVRIDMSEYMDKFSVTRLIGAPPGYVGYEEGGQLTEAIRTKPYSVILFDEIEKAHPDVFNVLLQVLDDGRLTDGQGRIVDFKNTLIIMTSNIGSHFILEDPNLSEDTREKVADELKARFKPEFLNRIDEIITFKALDLPAIKEIVKLSLKDLENKLKPKHITLEFSDKMVDYLANNAYDPHYGARPLRRYIQREIETSLAKKILANEVHEKSNVLIDLDNNHIVFKEV

http://purl.uniprot.org/uniprot/Q8RHQ8#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q8RHQ8#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/Q8RHQ8#attribution-E711A519A93D37BE424291FA19F65320
manual: true
evidence: ECO_0000255
source: PRU01251

http://purl.uniprot.org/uniprot/Q8RHQ8#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

Q8RHJ8
type: Protein
reviewed: true
created: 2002-08-30
modified: 2023-02-22
version: 113
mnemonic: CLPP_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIP07EC96E90BC5B0F2
alternative name: SIP7353D1C153228504
enzyme: http://purl.uniprot.org/enzyme/3.4.21.92
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIP4391072AD5D36FEF
annotation: SIP3F9843C340F7CF18
annotation: SIP9690859C46BFB3FB
annotation: SIP1391DBE434CCCF7C
annotation: SIP48218F9EF030654A
annotation: PRO_0000179559
annotation: SIP4941154813D11F0E
annotation: SIP88F03B59A9AA2134
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/720
classified with: GO_0005737
classified with: GO_0009368
classified with: GO_0004176
classified with: GO_0051117
classified with: GO_0004252
classified with: GO_0006515
sequence: MYNPTVIDNNGKSERAYDIYSRLLKDRIIFVGTAIDETVANSIIAQLLYLEAEDPEKDIIMYINSPGGSVTDGMAIYDTMNYIKPDVQTVCVGQAASMGAFLLAAGAKGKRFALENSRIMIHQPLISGGLKGQATDISIHANELLKIKDRLAELLAKNTGKTKEQILRDTERDNYLSSEEAVNYGLIDSVFRR
proteome: Chromosome

Q8RHJ8-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG0740
type: Resource
database: eggNOG
comment: Bacteria

cd07017
type: Resource
database: CDD
comment: S14_ClpP_2
signature sequence match: CDD cd07017 match 1

MF_00444
type: Resource
database: HAMAP
comment: ClpP
signature sequence match: HAMAP MF 00444 match 1

IPR001907
type: Resource
database: InterPro
comment: ClpP

IPR023562
type: Resource
database: InterPro
comment: ClpP/TepA

IPR033135
type: Resource
database: InterPro
comment: ClpP_His_AS

IPR018215
type: Resource
database: InterPro
comment: ClpP_Ser_AS

PTHR10381
type: Resource
database: PANTHER
comment: ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT
signature sequence match: PANTHER PTHR10381 match 1

PTHR10381:SF70
type: Resource
database: PANTHER
comment: ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT
signature sequence match: PANTHER PTHR10381:SF70 match 1

PF00574
type: Resource
database: Pfam
comment: CLP_protease
signature sequence match: Pfam PF00574 match 1

PR00127
type: Resource
database: PRINTS
comment: CLPPROTEASEP

TIGR00493
type: Resource
database: TIGRFAMs
comment: clpP
signature sequence match: TIGRFAMs TIGR00493 match 1

PS00382
type: Resource
database: PROSITE
comment: CLP_PROTEASE_HIS
signature sequence match: PROSITE PS00382 match 1

PS00381
type: Resource
database: PROSITE
comment: CLP_PROTEASE_SER
signature sequence match: PROSITE PS00381 match 1

SIP07EC96E90BC5B0F2
type: Structured Name
full name: ATP-dependent Clp protease proteolytic subunit
ec name: 3.4.21.92

SIP7353D1C153228504
type: Structured Name
full name: Endopeptidase Clp

clpP
type: Gene
locus name: FN2016

SIP4391072AD5D36FEF
type: Function Annotation
comment: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.

SIP9690859C46BFB3FB
type: Subunit Annotation
comment: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

SIP48218F9EF030654A
type: Similarity Annotation
comment: Belongs to the peptidase S14 family.

PRO_0000179559
type: Chain Annotation
comment: ATP-dependent Clp protease proteolytic subunit
mass: 21336
range: 22861399164860462tt1tt193

22861399164860462tt1
type: Position
type: ExactPosition
position: 1
reference: MYNPTVIDNNGKSERAYDIYSRLLKDRIIFVGTAIDETVANSIIAQLLYLEAEDPEKDIIMYINSPGGSVTDGMAIYDTMNYIKPDVQTVCVGQAASMGAFLLAAGAKGKRFALENSRIMIHQPLISGGLKGQATDISIHANELLKIKDRLAELLAKNTGKTKEQILRDTERDNYLSSEEAVNYGLIDSVFRR

22861399164860462tt193
type: Position
type: ExactPosition
position: 193
reference: MYNPTVIDNNGKSERAYDIYSRLLKDRIIFVGTAIDETVANSIIAQLLYLEAEDPEKDIIMYINSPGGSVTDGMAIYDTMNYIKPDVQTVCVGQAASMGAFLLAAGAKGKRFALENSRIMIHQPLISGGLKGQATDISIHANELLKIKDRLAELLAKNTGKTKEQILRDTERDNYLSSEEAVNYGLIDSVFRR

SIP4941154813D11F0E
type: Active Site Annotation
comment: Nucleophile
range: 22861399164860462tt97tt97

22861399164860462tt97
type: Position
type: ExactPosition
position: 97
reference: MYNPTVIDNNGKSERAYDIYSRLLKDRIIFVGTAIDETVANSIIAQLLYLEAEDPEKDIIMYINSPGGSVTDGMAIYDTMNYIKPDVQTVCVGQAASMGAFLLAAGAKGKRFALENSRIMIHQPLISGGLKGQATDISIHANELLKIKDRLAELLAKNTGKTKEQILRDTERDNYLSSEEAVNYGLIDSVFRR

22861399164860462tt122
type: Position
type: ExactPosition
position: 122
reference: MYNPTVIDNNGKSERAYDIYSRLLKDRIIFVGTAIDETVANSIIAQLLYLEAEDPEKDIIMYINSPGGSVTDGMAIYDTMNYIKPDVQTVCVGQAASMGAFLLAAGAKGKRFALENSRIMIHQPLISGGLKGQATDISIHANELLKIKDRLAELLAKNTGKTKEQILRDTERDNYLSSEEAVNYGLIDSVFRR

MYNPTVIDNNGKSERAYDIYSRLLKDRIIFVGTAIDETVANSIIAQLLYLEAEDPEKDIIMYINSPGGSVTDGMAIYDTMNYIKPDVQTVCVGQAASMGAFLLAAGAKGKRFALENSRIMIHQPLISGGLKGQATDISIHANELLKIKDRLAELLAKNTGKTKEQILRDTERDNYLSSEEAVNYGLIDSVFRR
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 21336

http://purl.uniprot.org/uniprot/Q8RHJ8#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q8RHJ8#attribution-83FF83956DB918F871897D2ABDA0D60B
manual: true
evidence: ECO_0000255
source: MF_00444

Q8RHJ9
type: Protein
reviewed: true
created: 2002-10-10
modified: 2023-05-03
version: 119
mnemonic: CLPX_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIPF43CC31C6B90A8EC
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIPE0F4E185EE5FF298
annotation: SIP8AD5405F1CED81C4
annotation: SIP105921175394C173
annotation: PRO_0000160358
annotation: SIPF52AC049BD4E7E1B
annotation: SIP974F9E2D7E0192E4
annotation: SIPA4AB2ED49A57B0B2
annotation: SIPC2571C0F30745726
annotation: SIP185ED657C9F0A31A
annotation: SIP71E07E69900A81E2
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/143
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/862
classified with: GO_0009376
classified with: GO_0005524
classified with: GO_0016887
classified with: GO_0140662
classified with: GO_0046983
classified with: GO_0051082
classified with: GO_0008270
classified with: GO_0051301
classified with: GO_0051603
sequence: Q8RHJ9-1
proteome: Chromosome

Q8RHJ9-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG1219
type: Resource
database: eggNOG
comment: Bacteria

cd19497
type: Resource
database: CDD
comment: RecA-like_ClpX
signature sequence match: CDD cd19497 match 1

http://purl.uniprot.org/gene3d/6.20.220.10
type: Resource
database: Gene3D
comment: ClpX chaperone, C4-type zinc finger domain
signature sequence match: Gene3D 6.20.220.10 match 1

MF_00175
type: Resource
database: HAMAP
comment: ClpX
signature sequence match: HAMAP MF 00175 match 1

IPR004487
type: Resource
database: InterPro
comment: Clp_protease_ATP-bd_su_ClpX

IPR046425
type: Resource
database: InterPro
comment: ClpX_bact

IPR010603
type: Resource
database: InterPro
comment: Znf_CppX_C4

IPR038366
type: Resource
database: InterPro
comment: Znf_CppX_C4_sf

PTHR48102:SF7
type: Resource
database: PANTHER
comment: ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL
signature sequence match: PANTHER PTHR48102:SF7 match 1

PTHR48102
type: Resource
database: PANTHER
comment: ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED
signature sequence match: PANTHER PTHR48102 match 1

PF06689
type: Resource
database: Pfam
comment: zf-C4_ClpX
signature sequence match: Pfam PF06689 match 1

SM00994
type: Resource
database: SMART
comment: zf-C4_ClpX
signature sequence match: SMART SM00994 match 1

SSF57716
type: Resource
database: SUPFAM
comment: Glucocorticoid receptor-like (DNA-binding domain)
signature sequence match: SUPFAM SSF57716 match 1

TIGR00382
type: Resource
database: TIGRFAMs
comment: clpX
signature sequence match: TIGRFAMs TIGR00382 match 1

PS51902
type: Resource
database: PROSITE
comment: CLPX_ZB
signature sequence match: PROSITE PS51902 match 1

SIPF43CC31C6B90A8EC
type: Structured Name
full name: ATP-dependent Clp protease ATP-binding subunit ClpX

clpX
type: Gene
locus name: FN2015

SIPE0F4E185EE5FF298
type: Function Annotation
comment: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.

SIP8AD5405F1CED81C4
type: Subunit Annotation
comment: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

SIP105921175394C173
type: Similarity Annotation
comment: Belongs to the ClpX chaperone family.

PRO_0000160358
type: Chain Annotation
comment: ATP-dependent Clp protease ATP-binding subunit ClpX
mass: 47357
range: 22861399164860718tt1tt423

22861399164860718tt1
type: Position
type: ExactPosition
position: 1
reference: Q8RHJ9-1

22861399164860718tt423
type: Position
type: ExactPosition
position: 423
reference: Q8RHJ9-1

SIPF52AC049BD4E7E1B
type: Domain Extent Annotation
comment: ClpX-type ZB
range: 22861399164860718tt1tt50

22861399164860718tt50
type: Position
type: ExactPosition
position: 50
reference: Q8RHJ9-1

22861399164860718tt8
type: Position
type: ExactPosition
position: 8
reference: Q8RHJ9-1

22861399164860718tt11
type: Position
type: ExactPosition
position: 11
reference: Q8RHJ9-1

22861399164860718tt31
type: Position
type: ExactPosition
position: 31
reference: Q8RHJ9-1

22861399164860718tt34
type: Position
type: ExactPosition
position: 34
reference: Q8RHJ9-1

22861399164860718tt130
type: Position
type: ExactPosition
position: 130
reference: Q8RHJ9-1

22861399164860718tt137
type: Position
type: ExactPosition
position: 137
reference: Q8RHJ9-1

Q8RHJ9-1
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 47357
value: MSKKMDRCSFCGRTEREVTQLFQGPGDVFICDSCVESCHSLLRDDMYSLAREYENLRDGKSSNNKNYKGKIELLKPVEIKAKLDEYVVGQDEAKKVLSVAVYNHYKRILNNGQDDDGVELQKSNVLLVGPTGSGKTLLAQTLAKILNVPFAIADATTLTEAGYVGDDVENVLVRLIQACNYDIPNAERGIIYIDEFDKIARKSENVSITRDVSGEGVQQALLKIIEGTKSQVPPEGGRKHPNQELIEIDTKNILFIVGGAFEGLEKIIKARTNKKVIGFGAEVQKQDNMGTEGEFFKKVLPEDLMKQGIIPELVGRLPVITTLDNLDEQTLINILTKPKNAIVKQYQKLCKLEGVKLEFTQEALTEIAKRALKRKMGARGLRAIIEHTMLDIMFELPSNNNIKEITITKDTIDNYKKAEIEYK

http://purl.uniprot.org/uniprot/Q8RHJ9#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q8RHJ9#attribution-CFB06F30A19C652E3C2E44B930DCAAA4
manual: true
evidence: ECO_0000255
source: MF_00175

http://purl.uniprot.org/uniprot/Q8RHJ9#attribution-53EBA6D767FE97D40C9959E24A2E919D
manual: true
evidence: ECO_0000255
source: PRU01250

Q8RGX1
type: Protein
reviewed: true
created: 2003-03-28
modified: 2023-02-22
version: 112
mnemonic: COAD_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIPF6F66FCD23803F87
alternative name: SIPCEC148E019BD360F
alternative name: SIP35682BD6712EB9F8
enzyme: http://purl.uniprot.org/enzyme/2.7.7.3
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIP4138A83834108656
annotation: SIP1485249B9A6A7490
annotation: SIP7D50FB11D6455A12
annotation: SIPF01C48BACE82B254
annotation: SIP375510C735C60EFE
annotation: SIP1D46F72F996483F7
annotation: SIPB2BCA829FB8C1B34
annotation: PRO_0000156210
annotation: SIPBAD870BFD504B4B0
annotation: SIPF094F087F289FA04
annotation: SIP922ADCED5EDE51C0
annotation: SIP479D73F2281CA7E8
annotation: SIPA17926FCA487A473
annotation: SIP453B276FBA0F4C7A
annotation: SIP8669D9C62A6DD213
annotation: SIP3451BB74E4555B8E
annotation: SIPBCBD200935E53725
annotation: SIP68CDD2048E731032
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/173
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/460
classified with: http://purl.uniprot.org/keywords/548
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005737
classified with: GO_0005524
classified with: GO_0004595
classified with: GO_0015937
sequence: MKIGVYAGSFDPITKGHQDIIERALKIVDKLIVVVMNNPTKNYWFNLDERKNLISKIFEGSDSIKVDEHAGLLVDFMAKNSCNILIKGLRDVKDFSEEMTYSFANKKLSNGEVDTIFIPTSEKYTYVSSTFVKELAFYNQSLTGYVDDKVIVDILNRAKEYRG
proteome: Chromosome

Q8RGX1-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG0669
type: Resource
database: eggNOG
comment: Bacteria

cd02163
type: Resource
database: CDD
comment: PPAT
signature sequence match: CDD cd02163 match 1

http://purl.uniprot.org/gene3d/3.40.50.620
type: Resource
database: Gene3D
comment: HUPs
signature sequence match: Gene3D 3.40.50.620 match 1
signature sequence match: Gene3D 3.40.50.620 match 2

MF_00151
type: Resource
database: HAMAP
comment: PPAT_bact
signature sequence match: HAMAP MF 00151 match 1

IPR004821
type: Resource
database: InterPro
comment: Cyt_trans-like

IPR001980
type: Resource
database: InterPro
comment: PPAT

IPR014729
type: Resource
database: InterPro
comment: Rossmann-like_a/b/a_fold

PTHR21342
type: Resource
database: PANTHER
comment: PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE
signature sequence match: PANTHER PTHR21342 match 1

PTHR21342:SF1
type: Resource
database: PANTHER
comment: PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE
signature sequence match: PANTHER PTHR21342:SF1 match 1

PF01467
type: Resource
database: Pfam
comment: CTP_transf_like
signature sequence match: Pfam PF01467 match 1

PR01020
type: Resource
database: PRINTS
comment: LPSBIOSNTHSS

SSF52374
type: Resource
database: SUPFAM
comment: Nucleotidylyl transferase
signature sequence match: SUPFAM SSF52374 match 1

TIGR01510
type: Resource
database: TIGRFAMs
comment: coaD_prev_kdtB
signature sequence match: TIGRFAMs TIGR01510 match 1

TIGR00125
type: Resource
database: TIGRFAMs
comment: cyt_tran_rel
signature sequence match: TIGRFAMs TIGR00125 match 1

SIPF6F66FCD23803F87
type: Structured Name
full name: Phosphopantetheine adenylyltransferase
ec name: 2.7.7.3

SIPCEC148E019BD360F
type: Structured Name
full name: Dephospho-CoA pyrophosphorylase

SIP35682BD6712EB9F8
type: Structured Name
full name: Pantetheine-phosphate adenylyltransferase
short name: PPAT

coaD
type: Gene
locus name: FN0156

SIP4138A83834108656
type: Function Annotation
comment: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

SIP375510C735C60EFE
type: Subunit Annotation
comment: Homohexamer.

SIPB2BCA829FB8C1B34
type: Similarity Annotation
comment: Belongs to the bacterial CoaD family.

PRO_0000156210
type: Chain Annotation
comment: Phosphopantetheine adenylyltransferase
mass: 18594
range: 22861399148998958tt1tt163

22861399148998958tt1
type: Position
type: ExactPosition
position: 1
reference: MKIGVYAGSFDPITKGHQDIIERALKIVDKLIVVVMNNPTKNYWFNLDERKNLISKIFEGSDSIKVDEHAGLLVDFMAKNSCNILIKGLRDVKDFSEEMTYSFANKKLSNGEVDTIFIPTSEKYTYVSSTFVKELAFYNQSLTGYVDDKVIVDILNRAKEYRG

22861399148998958tt163
type: Position
type: ExactPosition
position: 163
reference: MKIGVYAGSFDPITKGHQDIIERALKIVDKLIVVVMNNPTKNYWFNLDERKNLISKIFEGSDSIKVDEHAGLLVDFMAKNSCNILIKGLRDVKDFSEEMTYSFANKKLSNGEVDTIFIPTSEKYTYVSSTFVKELAFYNQSLTGYVDDKVIVDILNRAKEYRG

22861399148998958tt9
type: Position
type: ExactPosition
position: 9
reference: MKIGVYAGSFDPITKGHQDIIERALKIVDKLIVVVMNNPTKNYWFNLDERKNLISKIFEGSDSIKVDEHAGLLVDFMAKNSCNILIKGLRDVKDFSEEMTYSFANKKLSNGEVDTIFIPTSEKYTYVSSTFVKELAFYNQSLTGYVDDKVIVDILNRAKEYRG

22861399148998958tt10
type: Position
type: ExactPosition
position: 10
reference: MKIGVYAGSFDPITKGHQDIIERALKIVDKLIVVVMNNPTKNYWFNLDERKNLISKIFEGSDSIKVDEHAGLLVDFMAKNSCNILIKGLRDVKDFSEEMTYSFANKKLSNGEVDTIFIPTSEKYTYVSSTFVKELAFYNQSLTGYVDDKVIVDILNRAKEYRG

22861399148998958tt17
type: Position
type: ExactPosition
position: 17
reference: MKIGVYAGSFDPITKGHQDIIERALKIVDKLIVVVMNNPTKNYWFNLDERKNLISKIFEGSDSIKVDEHAGLLVDFMAKNSCNILIKGLRDVKDFSEEMTYSFANKKLSNGEVDTIFIPTSEKYTYVSSTFVKELAFYNQSLTGYVDDKVIVDILNRAKEYRG

22861399148998958tt41
type: Position
type: ExactPosition
position: 41
reference: MKIGVYAGSFDPITKGHQDIIERALKIVDKLIVVVMNNPTKNYWFNLDERKNLISKIFEGSDSIKVDEHAGLLVDFMAKNSCNILIKGLRDVKDFSEEMTYSFANKKLSNGEVDTIFIPTSEKYTYVSSTFVKELAFYNQSLTGYVDDKVIVDILNRAKEYRG

22861399148998958tt73
type: Position
type: ExactPosition
position: 73
reference: MKIGVYAGSFDPITKGHQDIIERALKIVDKLIVVVMNNPTKNYWFNLDERKNLISKIFEGSDSIKVDEHAGLLVDFMAKNSCNILIKGLRDVKDFSEEMTYSFANKKLSNGEVDTIFIPTSEKYTYVSSTFVKELAFYNQSLTGYVDDKVIVDILNRAKEYRG

22861399148998958tt87
type: Position
type: ExactPosition
position: 87
reference: MKIGVYAGSFDPITKGHQDIIERALKIVDKLIVVVMNNPTKNYWFNLDERKNLISKIFEGSDSIKVDEHAGLLVDFMAKNSCNILIKGLRDVKDFSEEMTYSFANKKLSNGEVDTIFIPTSEKYTYVSSTFVKELAFYNQSLTGYVDDKVIVDILNRAKEYRG

22861399148998958tt88
type: Position
type: ExactPosition
position: 88
reference: MKIGVYAGSFDPITKGHQDIIERALKIVDKLIVVVMNNPTKNYWFNLDERKNLISKIFEGSDSIKVDEHAGLLVDFMAKNSCNILIKGLRDVKDFSEEMTYSFANKKLSNGEVDTIFIPTSEKYTYVSSTFVKELAFYNQSLTGYVDDKVIVDILNRAKEYRG

22861399148998958tt90
type: Position
type: ExactPosition
position: 90
reference: MKIGVYAGSFDPITKGHQDIIERALKIVDKLIVVVMNNPTKNYWFNLDERKNLISKIFEGSDSIKVDEHAGLLVDFMAKNSCNILIKGLRDVKDFSEEMTYSFANKKLSNGEVDTIFIPTSEKYTYVSSTFVKELAFYNQSLTGYVDDKVIVDILNRAKEYRG

22861399148998958tt98
type: Position
type: ExactPosition
position: 98
reference: MKIGVYAGSFDPITKGHQDIIERALKIVDKLIVVVMNNPTKNYWFNLDERKNLISKIFEGSDSIKVDEHAGLLVDFMAKNSCNILIKGLRDVKDFSEEMTYSFANKKLSNGEVDTIFIPTSEKYTYVSSTFVKELAFYNQSLTGYVDDKVIVDILNRAKEYRG

22861399148998958tt124
type: Position
type: ExactPosition
position: 124
reference: MKIGVYAGSFDPITKGHQDIIERALKIVDKLIVVVMNNPTKNYWFNLDERKNLISKIFEGSDSIKVDEHAGLLVDFMAKNSCNILIKGLRDVKDFSEEMTYSFANKKLSNGEVDTIFIPTSEKYTYVSSTFVKELAFYNQSLTGYVDDKVIVDILNRAKEYRG

22861399148998958tt130
type: Position
type: ExactPosition
position: 130
reference: MKIGVYAGSFDPITKGHQDIIERALKIVDKLIVVVMNNPTKNYWFNLDERKNLISKIFEGSDSIKVDEHAGLLVDFMAKNSCNILIKGLRDVKDFSEEMTYSFANKKLSNGEVDTIFIPTSEKYTYVSSTFVKELAFYNQSLTGYVDDKVIVDILNRAKEYRG

SIP68CDD2048E731032
type: Site Annotation
comment: Transition state stabilizer
range: 22861399148998958tt17tt17

substrate

MKIGVYAGSFDPITKGHQDIIERALKIVDKLIVVVMNNPTKNYWFNLDERKNLISKIFEGSDSIKVDEHAGLLVDFMAKNSCNILIKGLRDVKDFSEEMTYSFANKKLSNGEVDTIFIPTSEKYTYVSSTFVKELAFYNQSLTGYVDDKVIVDILNRAKEYRG
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 18594

http://purl.uniprot.org/uniprot/Q8RGX1#attribution-1FBF028CE5C20B3CECCC520D3E79044A
manual: true
evidence: ECO_0000255
source: MF_00151

Q8RHR7
type: Protein
reviewed: true
created: 2002-10-10
modified: 2023-05-03
version: 113
mnemonic: COAE_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIP6C5CBBF5AA70C17E
alternative name: SIP7BD80E42975FEC74
enzyme: http://purl.uniprot.org/enzyme/2.7.1.24
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIP08A3473B54E56B11
annotation: SIPD8CEBCB4EC21E8C5
annotation: SIP5477A43A36A5A37A
annotation: SIP0BB2A733DC586C4E
annotation: SIPA5A91144ED1B66AF
annotation: PRO_0000172944
annotation: SIP4E6A463396930351
annotation: SIP716941E910772D6F
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/173
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/418
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005737
classified with: GO_0005524
classified with: GO_0004140
classified with: GO_0015937
classified with: GO_0016310
sequence: MSIMIIGLTGGIASGKSTVSKYLAEKGFKVYDADKIAKDISEKKSVQEEIISTFGNKILDKNGNIDRKKLKEIVFENKEKLEKLNGIIHPKVINFYKELKEKKTDKVIIFDVPLLFESGIDKFCDKILVVISDYEVQLNRIIERDKINRELAEKIIKSQLSNEERIKKADVVIENNSNLEDLFKKVERFCETI
proteome: Chromosome

Q8RHR7-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG0237
type: Resource
database: eggNOG
comment: Bacteria

cd02022
type: Resource
database: CDD
comment: DPCK
signature sequence match: CDD cd02022 match 1

MF_00376
type: Resource
database: HAMAP
comment: Dephospho_CoA_kinase
signature sequence match: HAMAP MF 00376 match 1

IPR001977
type: Resource
database: InterPro
comment: Depp_CoAkinase

PTHR10695:SF46
type: Resource
database: PANTHER
comment: BIFUNCTIONAL COENZYME A SYNTHASE-RELATED
signature sequence match: PANTHER PTHR10695:SF46 match 1

PTHR10695
type: Resource
database: PANTHER
comment: DEPHOSPHO-COA KINASE-RELATED
signature sequence match: PANTHER PTHR10695 match 1

PF01121
type: Resource
database: Pfam
comment: CoaE
signature sequence match: Pfam PF01121 match 1

TIGR00152
type: Resource
database: TIGRFAMs
comment: dephospho-CoA kinase
signature sequence match: TIGRFAMs TIGR00152 match 1

PS51219
type: Resource
database: PROSITE
comment: DPCK
signature sequence match: PROSITE PS51219 match 1

SIP6C5CBBF5AA70C17E
type: Structured Name
full name: Dephospho-CoA kinase
ec name: 2.7.1.24

SIP7BD80E42975FEC74
type: Structured Name
full name: Dephosphocoenzyme A kinase

coaE
type: Gene
locus name: FN1932

SIP08A3473B54E56B11
type: Function Annotation
comment: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.

SIPA5A91144ED1B66AF
type: Similarity Annotation
comment: Belongs to the CoaE family.

PRO_0000172944
type: Chain Annotation
comment: Dephospho-CoA kinase
mass: 22199
range: 22861399165384494tt1tt193

22861399165384494tt1
type: Position
type: ExactPosition
position: 1
reference: MSIMIIGLTGGIASGKSTVSKYLAEKGFKVYDADKIAKDISEKKSVQEEIISTFGNKILDKNGNIDRKKLKEIVFENKEKLEKLNGIIHPKVINFYKELKEKKTDKVIIFDVPLLFESGIDKFCDKILVVISDYEVQLNRIIERDKINRELAEKIIKSQLSNEERIKKADVVIENNSNLEDLFKKVERFCETI

22861399165384494tt193
type: Position
type: ExactPosition
position: 193
reference: MSIMIIGLTGGIASGKSTVSKYLAEKGFKVYDADKIAKDISEKKSVQEEIISTFGNKILDKNGNIDRKKLKEIVFENKEKLEKLNGIIHPKVINFYKELKEKKTDKVIIFDVPLLFESGIDKFCDKILVVISDYEVQLNRIIERDKINRELAEKIIKSQLSNEERIKKADVVIENNSNLEDLFKKVERFCETI

SIP4E6A463396930351
type: Domain Extent Annotation
comment: DPCK
range: 22861399165384494tt5tt193

22861399165384494tt5
type: Position
type: ExactPosition
position: 5
reference: MSIMIIGLTGGIASGKSTVSKYLAEKGFKVYDADKIAKDISEKKSVQEEIISTFGNKILDKNGNIDRKKLKEIVFENKEKLEKLNGIIHPKVINFYKELKEKKTDKVIIFDVPLLFESGIDKFCDKILVVISDYEVQLNRIIERDKINRELAEKIIKSQLSNEERIKKADVVIENNSNLEDLFKKVERFCETI

22861399165384494tt13
type: Position
type: ExactPosition
position: 13
reference: MSIMIIGLTGGIASGKSTVSKYLAEKGFKVYDADKIAKDISEKKSVQEEIISTFGNKILDKNGNIDRKKLKEIVFENKEKLEKLNGIIHPKVINFYKELKEKKTDKVIIFDVPLLFESGIDKFCDKILVVISDYEVQLNRIIERDKINRELAEKIIKSQLSNEERIKKADVVIENNSNLEDLFKKVERFCETI

22861399165384494tt18
type: Position
type: ExactPosition
position: 18
reference: MSIMIIGLTGGIASGKSTVSKYLAEKGFKVYDADKIAKDISEKKSVQEEIISTFGNKILDKNGNIDRKKLKEIVFENKEKLEKLNGIIHPKVINFYKELKEKKTDKVIIFDVPLLFESGIDKFCDKILVVISDYEVQLNRIIERDKINRELAEKIIKSQLSNEERIKKADVVIENNSNLEDLFKKVERFCETI

MSIMIIGLTGGIASGKSTVSKYLAEKGFKVYDADKIAKDISEKKSVQEEIISTFGNKILDKNGNIDRKKLKEIVFENKEKLEKLNGIIHPKVINFYKELKEKKTDKVIIFDVPLLFESGIDKFCDKILVVISDYEVQLNRIIERDKINRELAEKIIKSQLSNEERIKKADVVIENNSNLEDLFKKVERFCETI
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 22199

http://purl.uniprot.org/uniprot/Q8RHR7#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q8RHR7#attribution-5BBABE863AC0B55418D957FE3499D9F3
manual: true
evidence: ECO_0000255
source: MF_00376

Q8RFE4
type: Protein
reviewed: true
created: 2006-12-12
modified: 2023-02-22
version: 97
mnemonic: COAX_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIP9C2BC1CF6C19D180
alternative name: SIP5A689CF50805F96C
alternative name: SIP4F70A191848DB5A7
enzyme: http://purl.uniprot.org/enzyme/2.7.1.33
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIP12971470A770BD54
annotation: SIP6B51556C89925060
annotation: SIPEAD143771AC3A3B8
annotation: SIP56550A2B56DF99F6
annotation: SIP14E9C3AEA597B78E
annotation: SIP31224E4EACFA959F
annotation: SIPE6D14DF99C1AF392
annotation: PRO_0000267538
annotation: SIPD4A1C21DD61C1170
annotation: SIPF25CBFC07408035D
annotation: SIPBF66D363AE1685B8
annotation: SIP175A8AD95D095DD8
annotation: SIP2055AE74239F6B0F
annotation: SIPDD7F3E6CEB86684B
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/173
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/418
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/630
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005737
classified with: GO_0005524
classified with: GO_0046872
classified with: GO_0004594
classified with: GO_0015937
classified with: GO_0016310
sequence: Q8RFE4-1
proteome: Chromosome

Q8RFE4-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG1521
type: Resource
database: eggNOG
comment: Bacteria

cd00012
type: Resource
database: CDD
comment: NBD_sugar-kinase_HSP70_actin
signature sequence match: CDD cd00012 match 1

MF_01274
type: Resource
database: HAMAP
comment: Pantothen_kinase_3
signature sequence match: HAMAP MF 01274 match 1

IPR004619
type: Resource
database: InterPro
comment: Type_III_PanK

PTHR34265
type: Resource
database: PANTHER
comment: TYPE III PANTOTHENATE KINASE
signature sequence match: PANTHER PTHR34265 match 1

PTHR34265:SF1
type: Resource
database: PANTHER
comment: TYPE III PANTOTHENATE KINASE
signature sequence match: PANTHER PTHR34265:SF1 match 1

PF03309
type: Resource
database: Pfam
comment: Pan_kinase
signature sequence match: Pfam PF03309 match 1

TIGR00671
type: Resource
database: TIGRFAMs
comment: baf
signature sequence match: TIGRFAMs TIGR00671 match 1

SIP9C2BC1CF6C19D180
type: Structured Name
full name: Type III pantothenate kinase
ec name: 2.7.1.33

SIP5A689CF50805F96C
type: Structured Name
full name: PanK-III

SIP4F70A191848DB5A7
type: Structured Name
full name: Pantothenic acid kinase

coaX
type: Gene
locus name: FN0761

SIP12971470A770BD54
type: Function Annotation
comment: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.

SIPEAD143771AC3A3B8
type: Cofactor Annotation
comment: A monovalent cation. Ammonium or potassium.
cofactor: CHEBI_28938
cofactor: CHEBI_29103

SIP14E9C3AEA597B78E
type: Subunit Annotation
comment: Homodimer.

SIPE6D14DF99C1AF392
type: Similarity Annotation
comment: Belongs to the type III pantothenate kinase family.

PRO_0000267538
type: Chain Annotation
comment: Type III pantothenate kinase
mass: 28601
range: 22861399130977326tt1tt256

22861399130977326tt1
type: Position
type: ExactPosition
position: 1
reference: Q8RFE4-1

22861399130977326tt256
type: Position
type: ExactPosition
position: 256
reference: Q8RFE4-1

SIPD4A1C21DD61C1170
type: Active Site Annotation
comment: Proton acceptor
range: 22861399130977326tt111tt111

22861399130977326tt111
type: Position
type: ExactPosition
position: 111
reference: Q8RFE4-1

22861399130977326tt6
type: Position
type: ExactPosition
position: 6
reference: Q8RFE4-1

22861399130977326tt13
type: Position
type: ExactPosition
position: 13
reference: Q8RFE4-1

22861399130977326tt109
type: Position
type: ExactPosition
position: 109
reference: Q8RFE4-1

22861399130977326tt112
type: Position
type: ExactPosition
position: 112
reference: Q8RFE4-1

22861399130977326tt132
type: Position
type: ExactPosition
position: 132
reference: Q8RFE4-1

22861399130977326tt135
type: Position
type: ExactPosition
position: 135
reference: Q8RFE4-1

22861399130977326tt186
type: Position
type: ExactPosition
position: 186
reference: Q8RFE4-1

substrate

Q8RFE4-1
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 28601
value: MIIGIDIGNTHIVTGIYDNNGELISTFRIATNDKMTEDEYFSYFNNITKYNEISIKKVDAILISSVVPNIIITFQFFARKYFKVEATIVDLEKKLPFTFAKGINYTGFGADRIIDITEAMQKYPDKNLVIFDFGTATTYDVLKKGVYIGGGILPGIDMSINALYGNTAKLPRVKFTTPSSVLGTDTMKQIQAAIFFGYAGQIKHIIKKINEELNEEIFVLATGGLGKILSAEIDEIDEYDANLSLKGLYTLYKLNK

http://purl.uniprot.org/uniprot/Q8RFE4#attribution-857E44A974A72E34E0B0BBCB2B0A8D28
manual: true
evidence: ECO_0000255
source: MF_01274

Q8R666
type: Protein
reviewed: true
created: 2003-10-10
modified: 2023-02-22
version: 100
mnemonic: COBS_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIPC8F0476443F80643
alternative name: SIP15C415C9304BACEC
alternative name: SIPAAFD642635A00D3E
enzyme: http://purl.uniprot.org/enzyme/2.7.8.26
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIP7993E21AFF8C410C
annotation: SIP62ACD959BAC5959C
annotation: SIP9D254B1C65CEEEDD
annotation: SIP6F5847796D45CFD2
annotation: SIPC012637117937B53
annotation: SIPC387D5F01900AE65
annotation: SIPEE25361DBDAC1FBE
annotation: PRO_0000146879
annotation: SIP088B914F1D3B5CAD
annotation: SIPC2F9D1D2B8EC6259
annotation: SIPC4639FD5E80AC7EF
annotation: SIP9040F421F11E9DB4
annotation: SIP033E20A38C0DD85E
annotation: SIP4F7D7928E679890E
annotation: SIP9D972C348FD4BC9D
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/997
classified with: http://purl.uniprot.org/keywords/169
classified with: http://purl.uniprot.org/keywords/460
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/808
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0005886
classified with: GO_0051073
classified with: GO_0008818
classified with: GO_0009236
sequence: Q8R666-1
proteome: Chromosome

Q8R666-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG0368
type: Resource
database: eggNOG
comment: Bacteria

MF_00719
type: Resource
database: HAMAP
comment: CobS
signature sequence match: HAMAP MF 00719 match 1

IPR003805
type: Resource
database: InterPro
comment: CobS

PTHR34148
type: Resource
database: PANTHER
comment: ADENOSYLCOBINAMIDE-GDP RIBAZOLETRANSFERASE
signature sequence match: PANTHER PTHR34148 match 1

PTHR34148:SF1
type: Resource
database: PANTHER
comment: ADENOSYLCOBINAMIDE-GDP RIBAZOLETRANSFERASE
signature sequence match: PANTHER PTHR34148:SF1 match 1

PF02654
type: Resource
database: Pfam
comment: CobS
signature sequence match: Pfam PF02654 match 1

TIGR00317
type: Resource
database: TIGRFAMs
comment: cobS
signature sequence match: TIGRFAMs TIGR00317 match 1

SIPC8F0476443F80643
type: Structured Name
full name: Adenosylcobinamide-GDP ribazoletransferase
ec name: 2.7.8.26

SIP15C415C9304BACEC
type: Structured Name
full name: Cobalamin synthase

SIPAAFD642635A00D3E
type: Structured Name
full name: Cobalamin-5'-phosphate synthase

cobS
type: Gene
locus name: FN0912

SIP7993E21AFF8C410C
type: Function Annotation
comment: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.

SIPEE25361DBDAC1FBE
type: Similarity Annotation
comment: Belongs to the CobS family.

PRO_0000146879
type: Chain Annotation
comment: Adenosylcobinamide-GDP ribazoletransferase
mass: 30922
range: 22861398861559342tt1tt278

22861398861559342tt1
type: Position
type: ExactPosition
position: 1
reference: Q8R666-1

22861398861559342tt278
type: Position
type: ExactPosition
position: 278
reference: Q8R666-1

SIP088B914F1D3B5CAD
type: Transmembrane Annotation
comment: Helical
range: 22861398861559342tt35tt55

22861398861559342tt35
type: Position
type: ExactPosition
position: 35
reference: Q8R666-1

22861398861559342tt55
type: Position
type: ExactPosition
position: 55
reference: Q8R666-1

SIPC2F9D1D2B8EC6259
type: Transmembrane Annotation
comment: Helical
range: 22861398861559342tt62tt82

22861398861559342tt62
type: Position
type: ExactPosition
position: 62
reference: Q8R666-1

22861398861559342tt82
type: Position
type: ExactPosition
position: 82
reference: Q8R666-1

SIPC4639FD5E80AC7EF
type: Transmembrane Annotation
comment: Helical
range: 22861398861559342tt116tt136

22861398861559342tt116
type: Position
type: ExactPosition
position: 116
reference: Q8R666-1

22861398861559342tt136
type: Position
type: ExactPosition
position: 136
reference: Q8R666-1

SIP9040F421F11E9DB4
type: Transmembrane Annotation
comment: Helical
range: 22861398861559342tt141tt161

22861398861559342tt141
type: Position
type: ExactPosition
position: 141
reference: Q8R666-1

22861398861559342tt161
type: Position
type: ExactPosition
position: 161
reference: Q8R666-1

SIP033E20A38C0DD85E
type: Transmembrane Annotation
comment: Helical
range: 22861398861559342tt185tt205

22861398861559342tt185
type: Position
type: ExactPosition
position: 185
reference: Q8R666-1

22861398861559342tt205
type: Position
type: ExactPosition
position: 205
reference: Q8R666-1

SIP4F7D7928E679890E
type: Transmembrane Annotation
comment: Helical
range: 22861398861559342tt222tt242

22861398861559342tt222
type: Position
type: ExactPosition
position: 222
reference: Q8R666-1

22861398861559342tt242
type: Position
type: ExactPosition
position: 242
reference: Q8R666-1

SIP9D972C348FD4BC9D
type: Transmembrane Annotation
comment: Helical
range: 22861398861559342tt257tt277

22861398861559342tt257
type: Position
type: ExactPosition
position: 257
reference: Q8R666-1

22861398861559342tt277
type: Position
type: ExactPosition
position: 277
reference: Q8R666-1

Q8R666-1
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 30922
value: MKGFLLLLSFMTRIPMPKTDYDEEKLGKSMKYFPVVGIIVGFILLFFCIIFNFILKNISYSAVLPLMIIVVILTDLITTGALHLDGLADTFDGIFSYRSKHKMLEIMKDSRLGSNGALALILYFLLKFILLFSLTIESREAAVYAIITYPVVSRFCSVVSCASSPYARGSGMGKTFVDNIKTCGLIVATVITLLYTIGMLFMPFILFTNYSLPMQFMIRSVLIIVIIVGLLALFAFAFSKLIERKIGGITGDTLGALLEISSLVYIFLFLVIPTFFIG

http://purl.uniprot.org/uniprot/Q8R666#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q8R666#attribution-F9FF836B4CDE0FA70381736F117C802A
manual: true
evidence: ECO_0000255
source: MF_00719

Q8RF14
type: Protein
reviewed: true
created: 2003-07-25
modified: 2023-02-22
version: 111
mnemonic: COBT_FUSNN
citation: http://purl.uniprot.org/citations/11889109
recommended name: SIP44FD3869BCEDE5D4
alternative name: SIP8312F09AB35E48E2
enzyme: http://purl.uniprot.org/enzyme/2.4.2.21
organism: http://purl.uniprot.org/taxonomy/190304
annotation: SIPE16EC556CC0CF083
annotation: SIP80E26F2F9989783F
annotation: SIP37DC8F4FEF397518
annotation: SIPDD4307CF9F54E2AE
annotation: PRO_0000167051
annotation: SIP035D8FEE2C53A190
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/169
classified with: http://purl.uniprot.org/keywords/328
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0008939
classified with: GO_0009236
sequence: Q8RF14-1
proteome: Chromosome

Q8RF14-citation-11889109
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355
type: Strain

COG2038
type: Resource
database: eggNOG
comment: Bacteria

cd02439
type: Resource
database: CDD
comment: DMB-PRT_CobT
signature sequence match: CDD cd02439 match 1

MF_00230
type: Resource
database: HAMAP
comment: CobT
signature sequence match: HAMAP MF 00230 match 1

IPR003200
type: Resource
database: InterPro
comment: Nict_dMeBzImd_PRibTrfase

IPR017846
type: Resource
database: InterPro
comment: Nict_dMeBzImd_PRibTrfase_bact

IPR023195
type: Resource
database: InterPro
comment: Nict_dMeBzImd_PRibTrfase_N

IPR036087
type: Resource
database: InterPro
comment: Nict_dMeBzImd_PRibTrfase_sf

PTHR43463
type: Resource
database: PANTHER
comment: NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE
signature sequence match: PANTHER PTHR43463 match 1

PTHR43463:SF1
type: Resource
database: PANTHER
comment: NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE
signature sequence match: PANTHER PTHR43463:SF1 match 1

PF02277
type: Resource
database: Pfam
comment: DBI_PRT
signature sequence match: Pfam PF02277 match 1

SSF52733
type: Resource
database: SUPFAM
comment: Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT)
signature sequence match: SUPFAM SSF52733 match 1

TIGR03160
type: Resource
database: TIGRFAMs
comment: cobT_DBIPRT
signature sequence match: TIGRFAMs TIGR03160 match 1

SIP44FD3869BCEDE5D4
type: Structured Name
full name: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
short name: NN:DBI PRT
ec name: 2.4.2.21

SIP8312F09AB35E48E2
type: Structured Name
full name: N(1)-alpha-phosphoribosyltransferase

cobT
type: Gene
locus name: FN0910

SIPE16EC556CC0CF083
type: Function Annotation
comment: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

SIPDD4307CF9F54E2AE
type: Similarity Annotation
comment: Belongs to the CobT family.

PRO_0000167051
type: Chain Annotation
comment: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
mass: 39212
range: 22861399129666606tt1tt354

22861399129666606tt1
type: Position
type: ExactPosition
position: 1
reference: Q8RF14-1

22861399129666606tt354
type: Position
type: ExactPosition
position: 354
reference: Q8RF14-1

SIP035D8FEE2C53A190
type: Active Site Annotation
comment: Proton acceptor
range: 22861399129666606tt321tt321

22861399129666606tt321
type: Position
type: ExactPosition
position: 321
reference: Q8RF14-1

Q8RF14-1
type: Simple Sequence
modified: 2002-06-01
version: 1
mass: 39212
value: MKDKNCLFDLINKIESIDNVSIKKAQTELDRKMKPKDSLGVLEDICKKTAGIYGYPLKKLEKKCHIVVAADNGIIEEGVSSCPIEYTSIVSEAMLNQIACIGIFTKTLGIDLNVVDIGMKNDIKRNYPNLIHKKIRRGTNNFYKERAMSINECLEAIFTGIDIINEKSKDYDMFSNGEMGIANTTTSSALLYSVTRQNIDDIVGRGGGLSDEGLNKKKKVIIEACERYNTFEMDAVEMLASVGGFDLACMLGIYVGAALNKKLILVDGFISSVAALLACSLNKNIQDYLLFTHKSEEPGVNIILDYLKEKTFLNMNMRLGEGTGAVLACPIIDCAIEMINTMKSPEEVYNLFNK

http://purl.uniprot.org/uniprot/Q8RF14#attribution-F89C7A668028CFF7BB253452051D67D3
manual: true
evidence: ECO_0000255
source: MF_00230

C7NBY4
type: Protein
reviewed: true
created: 2017-11-22
modified: 2023-02-22
version: 52
mnemonic: CS13A_LEPBD
citation: http://purl.uniprot.org/citations/21304648
citation: http://purl.uniprot.org/citations/26593719
citation: http://purl.uniprot.org/citations/27669025
citation: http://purl.uniprot.org/citations/28475872
citation: http://purl.uniprot.org/citations/28111461
citation: http://purl.uniprot.org/citations/28757251
recommended name: SIP9BEA9F0E0C2FEFB3
alternative name: SIP0EEDE40397FA1B7A
alternative name: SIP4EBEEE85D2495737
enzyme: http://purl.uniprot.org/enzyme/3.1.-.-
organism: http://purl.uniprot.org/taxonomy/523794
annotation: SIP4A153A8611C279C9
annotation: SIP2EF386F6EF92A3E8
annotation: SIP667AB37DC6806C81
annotation: SIPE59401CE5E2876AC
annotation: SIPA5459E26872E7A5E
annotation: SIPA0E4D66F3782DEF0
annotation: SIP9AA947314ECFAACE
annotation: SIP377D00185C0130BE
annotation: PRO_0000442266
annotation: SIPC50DD6087232EF91
annotation: SIP273E9BDF381DDC52
annotation: SIP4DAAC350EF114AE1
annotation: SIP387B0EB17C502EAA
annotation: SIP4594BAF7D347E394
annotation: SIP24FAE65BE7EE2B5B
annotation: SIPB5FCE92798CAA9BB
annotation: SIPAACDD9471E479243
annotation: SIP79B0F1B4F7C5AADD
annotation: SIP2649F544945C8A21
annotation: SIPB7C431DFB8B4AAA0
annotation: SIPD45938369B490144
annotation: SIPDECFE6CDA7128610
annotation: SIPA151790369912C79
annotation: SIP7C1DA6A1B2458F3C
annotation: SIP24A00151ABDF7234
annotation: SIP7168253E7F3D789E
annotation: SIP22C9F587F3F1FB97
annotation: SIPF09AAD90F1CEA309
annotation: SIP1A41AE5ECAD8AD43
annotation: SIP2428682DD2044357
annotation: SIP851F2A555F432797
annotation: SIP34DA156C20413CBB
annotation: SIPA6274030B5C30140
annotation: SIPD83E872D6634ABC9
annotation: SIPE69D8AF46E0E6DD8
annotation: SIPBA36F3B067F23920
annotation: SIP898EC48559777515
annotation: SIPE477E27E4CA5E18B
annotation: SIP4A43C5C388F6F074
annotation: SIPAEC73D3DFEE754CD
annotation: SIP5115BF22257822F8
annotation: SIP9ACBC202E4F1CB84
annotation: SIP85C84E39A37FC267
annotation: SIP2369BC816D347CB3
annotation: SIPCB4FE7790CE71272
annotation: SIPCD05D32112C65598
annotation: SIPDAC845EAB2108BC8
annotation: SIPBA0CA6A91DBE98CD
annotation: SIP31BAAFFC28BC1ED8
annotation: SIP32D9F456EEEB71B4
annotation: SIP683A4992C095A00B
annotation: SIPCF7CB0D7EDC758E6
annotation: SIPF67AD3906EFB2CEF
annotation: SIP9017AAAD6E5DC5F6
annotation: SIP3F4AC8E2000FA2BE
annotation: SIP5DE0D935EAD6078D
annotation: SIP4FC755BBACF65E1E
annotation: SIP25E274A7F72AAFE8
annotation: SIP1C5290E3656664EA
annotation: SIP7F1BC0711153856C
annotation: SIPF08842ECC13A4EE0
annotation: SIPC620A39B0B03BD0C
annotation: SIP96BB59176B5ADA83

C7NBY4-citation-21304648
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 14201 / DSM 1135 / JCM 12969 / NCTC 10249 / C-1013-b
type: Strain

C7NBY4-citation-26593719
type: Citation Statement
scope: IDENTIFICATION
scope: DOMAIN

C7NBY4-citation-27669025
type: Citation Statement
scope: FUNCTION IN CRRNA PROCESSING
scope: FUNCTION IN TARGET SSRNA CLEAVAGE
scope: COFACTOR
scope: FUNCTION AS AN ENDORIBONUCLEASE
scope: BIOTECHNOLOGY
scope: MUTAGENESIS OF 472-ARG--HIS-477; 1048-ARG--HIS-1053 AND ARG-1079
scope: RNA-BINDING

C7NBY4-citation-28475872
type: Citation Statement
scope: FUNCTION IN CRRNA PROCESSING
scope: FUNCTION AS AN ENDORIBONUCLEASE
scope: DOMAIN
scope: MUTAGENESIS OF GLU-299; LYS-310; ARG-311; ASN-314; ARG-1072; ASP-1078; 1079-ARG-LYS-1080; ARG-1079; LYS-1080; LYS-1082 AND LYS-1087

C7NBY4-citation-28111461
type: Citation Statement
scope: NOMENCLATURE

C7NBY4-citation-28757251
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (3.09 ANGSTROMS) IN COMPLEX WITH CRRNA AND TARGET SSRNA
scope: STRUCTURE BY ELECTRON MICROSCOPY (3.2 ANGSTROMS) IN COMPLEX WITH CRRNA
scope: FUNCTION IN CRRNA PROCESSING
scope: FUNCTION IN TARGET SSRNA CLEAVAGE
scope: ACTIVITY REGULATION
scope: SUBUNIT
scope: DOMAIN
scope: RNA-BINDING
scope: MUTAGENESIS OF LYS-2; LYS-5; ARG-322; GLN-371; PHE-375; HIS-473; GLN-519; LYS-558; TYR-601; LYS-718; LYS-783; ARG-809; LYS-845; ARG-857; TYR-938; LYS-942; HIS-962; ARG-963; PHE-995; ASN-997; LYS-998; ARG-1072; ARG-1079; LYS-1082; LYS-1108 AND ARG-1135

5XWP
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 3.08
chain sequence mapping: PDB 5XWP tt1tt1159

PDB 5XWP tt1tt1159
chain: A/B=1-1159

5XWY
type: Structure Resource
database: PDB
method: Electron Microscopy
resolution: 3.20
chain sequence mapping: PDB 5XWY tt1tt1159

PDB 5XWY tt1tt1159
chain: A=1-1159

ENOG5032JQS
type: Resource
database: eggNOG
comment: Bacteria

SIP9BEA9F0E0C2FEFB3
type: Structured Name
full name: CRISPR-associated endoribonuclease Cas13a
ec name: 3.1.-.-

SIP0EEDE40397FA1B7A
type: Structured Name
full name: CRISPR-associated endoribonuclease C2c2
short name: EndoRNase

SIP4EBEEE85D2495737
type: Structured Name
full name: LbuC2c2

cas13a
type: Gene
alternative label: c2c2
locus name: Lebu_1799

SIP4A153A8611C279C9
type: Function Annotation
comment: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements (spacer sequences) and target invading nucleic acids. Unlike many single-component effectors, this CRISPR-Cas system targets RNA (PubMed:27669025). CRISPR clusters are transcribed from pre-CRISPR RNA (crRNA) and processed into crRNA by this protein (PubMed:27669025, PubMed:28475872, PubMed:28757251). pre-crRNA processing yields a 5'-OH and probably a 2',3'-cyclic phosphate (PubMed:27669025). Also cleaves pre-crRNA from several other type VI-A CRISPR systems (PubMed:28475872). Cleaves linear target ssRNA in a crRNA-dependent fashion, preferentially before U residues (PubMed:27669025, PubMed:28475872). Cleavage of target ssRNA is about 80-fold faster than pre-crRNA processing and uses a different active site (PubMed:27669025). Binding a viable target RNA target activates this protein for non-specific RNA degradation in vitro (called collateral RNA degradation) (PubMed:27669025, PubMed:28475872, PubMed:28757251). Activation occurs with 10 fM target RNA (PubMed:28475872). crRNA maturation is not essential for activation of RNA degradation, but lack of mature crRNA (due to mutagenesis) decreases activation levels (PubMed:28475872). This system has a 3' protospacer flanking site in the target RNA (PFS), which is C and unavailable to base pair with crRNA (PFS is equivalent to PAM, the protospacer adjacent motif) (PubMed:28757251).

SIP2EF386F6EF92A3E8
type: Cofactor Annotation
comment: Pre-crRNA processing is metal independent, while crRNA-guided target RNA cleavage is dependent on divalent metal (i.e. inhibited by EDTA) (PubMed:27669025).
cofactor: CHEBI_60240

SIP667AB37DC6806C81
type: Activity Regulation Annotation
comment: Target RNA acts as an activator for non-specific ssRNA cleavage; the target RNA and complementary crRNA must both be at least 20 nucleotides long to activate the HEPN-like catalytic pocket for RNase activity (PubMed:28757251).

SIPE59401CE5E2876AC
type: Subunit Annotation
comment: Crystals show the 3'-end of target RNA interacting with an adjacent protein molecule, and mutagenesis of those amino acid residues decreases target RNA cleavage, but it is not clear if this is physiological (PubMed:28757251).

SIPA5459E26872E7A5E
type: Domain Annotation
comment: The X-ray structure in complex with crRNA and target RNA shows a crRNA-recognition lobe (REC, residues 1-360) which anchors the crRNA repeat and a nuclease lobe (NUC, residues 361-1159) which binds the spacer crRNA-target RNA duplex and cleaves target RNA (PubMed:28757251). The target ssRNase active sites are within the 2 HEPN-like folds, which interact in vivo to form the functional active site (PubMed:26593719, PubMed:28757251). The N-terminal region and HEPN-like fold 2 play a role in pre-crRNA processing (PubMed:28475872). Binding of target RNA to the Cas13a-crRNA complex induces conformational changes that include bringing the 2 HEPN-like domains together to form the target cleavage active site, widening the channel that binds the crRNA-target RNA duplex, facilitating contact between the NUC lobe and the RNA duplex, and altering the conformation of the crRNA (PubMed:28757251).

SIPA0E4D66F3782DEF0
type: Biotechnology Annotation
comment: Can be used to detect low levels of cellular transcripts, which might be useful to create sequence-specific RNA-targeting tools (PubMed:27669025).

SIP9AA947314ECFAACE
type: Annotation
comment: Part of a type VI-A uridine-prefering CRISPR-Cas system.

SIP377D00185C0130BE
type: Similarity Annotation
comment: Belongs to the CRISPR-associated endoribonuclease Cas13a family.

PRO_0000442266
type: Chain Annotation
comment: CRISPR-associated endoribonuclease Cas13a
mass: 138478
range: 18919632699733038tt1tt1159

18919632699733038tt1
type: Position
type: ExactPosition
position: 1
reference: C7NBY4-1

18919632699733038tt1159
type: Position
type: ExactPosition
position: 1159
reference: C7NBY4-1

SIPC50DD6087232EF91
type: Region Annotation
comment: NTD
range: 18919632699733038tt1tt170

18919632699733038tt170
type: Position
type: ExactPosition
position: 170
reference: C7NBY4-1

SIP273E9BDF381DDC52
type: Region Annotation
comment: Binds crRNA repeat and spacer
range: 18919632699733038tt1tt11

18919632699733038tt11
type: Position
type: ExactPosition
position: 11
reference: C7NBY4-1

SIP4DAAC350EF114AE1
type: Region Annotation
comment: Binds crRNA repeat
range: 18919632699733038tt139tt151

18919632699733038tt139
type: Position
type: ExactPosition
position: 139
reference: C7NBY4-1

18919632699733038tt151
type: Position
type: ExactPosition
position: 151
reference: C7NBY4-1

SIP387B0EB17C502EAA
type: Region Annotation
comment: Helical-1
range: 18919632699733038tt171tt360

18919632699733038tt171
type: Position
type: ExactPosition
position: 171
reference: C7NBY4-1

18919632699733038tt360
type: Position
type: ExactPosition
position: 360
reference: C7NBY4-1

SIP4594BAF7D347E394
type: Region Annotation
comment: Binds crRNA repeat
range: 18919632699733038tt172tt176

18919632699733038tt172
type: Position
type: ExactPosition
position: 172
reference: C7NBY4-1

18919632699733038tt176
type: Position
type: ExactPosition
position: 176
reference: C7NBY4-1

SIP24FAE65BE7EE2B5B
type: Region Annotation
comment: Binds crRNA repeat
range: 18919632699733038tt224tt233

18919632699733038tt224
type: Position
type: ExactPosition
position: 224
reference: C7NBY4-1

18919632699733038tt233
type: Position
type: ExactPosition
position: 233
reference: C7NBY4-1

SIPB5FCE92798CAA9BB
type: Region Annotation
comment: Binds crRNA repeat
range: 18919632699733038tt271tt276

18919632699733038tt271
type: Position
type: ExactPosition
position: 271
reference: C7NBY4-1

18919632699733038tt276
type: Position
type: ExactPosition
position: 276
reference: C7NBY4-1

SIPAACDD9471E479243
type: Region Annotation
comment: Binds crRNA repeat
range: 18919632699733038tt294tt297

18919632699733038tt294
type: Position
type: ExactPosition
position: 294
reference: C7NBY4-1

18919632699733038tt297
type: Position
type: ExactPosition
position: 297
reference: C7NBY4-1

SIP79B0F1B4F7C5AADD
type: Region Annotation
comment: Binds crRNA repeat
range: 18919632699733038tt301tt305

18919632699733038tt301
type: Position
type: ExactPosition
position: 301
reference: C7NBY4-1

18919632699733038tt305
type: Position
type: ExactPosition
position: 305
reference: C7NBY4-1

SIP2649F544945C8A21
type: Region Annotation
comment: Binds crRNA processing site
range: 18919632699733038tt319tt328

18919632699733038tt319
type: Position
type: ExactPosition
position: 319
reference: C7NBY4-1

18919632699733038tt328
type: Position
type: ExactPosition
position: 328
reference: C7NBY4-1

SIPB7C431DFB8B4AAA0
type: Region Annotation
comment: Binds crRNA repeat
range: 18919632699733038tt336tt340

18919632699733038tt336
type: Position
type: ExactPosition
position: 336
reference: C7NBY4-1

18919632699733038tt340
type: Position
type: ExactPosition
position: 340
reference: C7NBY4-1

SIPD45938369B490144
type: Region Annotation
comment: HEPN-like fold 1-I
range: 18919632699733038tt361tt508

18919632699733038tt361
type: Position
type: ExactPosition
position: 361
reference: C7NBY4-1

18919632699733038tt508
type: Position
type: ExactPosition
position: 508
reference: C7NBY4-1

SIPDECFE6CDA7128610
type: Region Annotation
comment: Binds crRNA repeat
range: 18919632699733038tt371tt378

18919632699733038tt371
type: Position
type: ExactPosition
position: 371
reference: C7NBY4-1

18919632699733038tt378
type: Position
type: ExactPosition
position: 378
reference: C7NBY4-1

SIPA151790369912C79
type: Region Annotation
comment: Helical-2
range: 18919632699733038tt509tt751

18919632699733038tt509
type: Position
type: ExactPosition
position: 509
reference: C7NBY4-1

18919632699733038tt751
type: Position
type: ExactPosition
position: 751
reference: C7NBY4-1

SIP7C1DA6A1B2458F3C
type: Region Annotation
comment: Binds target RNA
range: 18919632699733038tt519tt522

18919632699733038tt519
type: Position
type: ExactPosition
position: 519
reference: C7NBY4-1

18919632699733038tt522
type: Position
type: ExactPosition
position: 522
reference: C7NBY4-1

SIP24A00151ABDF7234
type: Region Annotation
comment: Binds crRNA spacer
range: 18919632699733038tt547tt558

18919632699733038tt547
type: Position
type: ExactPosition
position: 547
reference: C7NBY4-1

18919632699733038tt558
type: Position
type: ExactPosition
position: 558
reference: C7NBY4-1

SIP7168253E7F3D789E
type: Region Annotation
comment: Binds target RNA
range: 18919632699733038tt590tt597

18919632699733038tt590
type: Position
type: ExactPosition
position: 590
reference: C7NBY4-1

18919632699733038tt597
type: Position
type: ExactPosition
position: 597
reference: C7NBY4-1

SIP22C9F587F3F1FB97
type: Region Annotation
comment: Binds crRNA spacer
range: 18919632699733038tt718tt722

18919632699733038tt718
type: Position
type: ExactPosition
position: 718
reference: C7NBY4-1

18919632699733038tt722
type: Position
type: ExactPosition
position: 722
reference: C7NBY4-1

SIPF09AAD90F1CEA309
type: Region Annotation
comment: HEPN-like fold 1-II
range: 18919632699733038tt752tt813

18919632699733038tt752
type: Position
type: ExactPosition
position: 752
reference: C7NBY4-1

18919632699733038tt813
type: Position
type: ExactPosition
position: 813
reference: C7NBY4-1

SIP1A41AE5ECAD8AD43
type: Region Annotation
comment: Binds crRNA repeat
range: 18919632699733038tt780tt783

18919632699733038tt780
type: Position
type: ExactPosition
position: 780
reference: C7NBY4-1

18919632699733038tt783
type: Position
type: ExactPosition
position: 783
reference: C7NBY4-1

SIP2428682DD2044357
type: Region Annotation
comment: Binds crRNA spacer and target RNA
range: 18919632699733038tt804tt810

18919632699733038tt804
type: Position
type: ExactPosition
position: 804
reference: C7NBY4-1

18919632699733038tt810
type: Position
type: ExactPosition
position: 810
reference: C7NBY4-1

SIP851F2A555F432797
type: Region Annotation
comment: Linker
range: 18919632699733038tt814tt946

18919632699733038tt814
type: Position
type: ExactPosition
position: 814
reference: C7NBY4-1

18919632699733038tt946
type: Position
type: ExactPosition
position: 946
reference: C7NBY4-1

SIP34DA156C20413CBB
type: Region Annotation
comment: Binds crRNA spacer
range: 18919632699733038tt845tt857

18919632699733038tt845
type: Position
type: ExactPosition
position: 845
reference: C7NBY4-1

18919632699733038tt857
type: Position
type: ExactPosition
position: 857
reference: C7NBY4-1

SIPA6274030B5C30140
type: Region Annotation
comment: Binds crRNA spacer
range: 18919632699733038tt938tt942

18919632699733038tt938
type: Position
type: ExactPosition
position: 938
reference: C7NBY4-1

18919632699733038tt942
type: Position
type: ExactPosition
position: 942
reference: C7NBY4-1

SIPD83E872D6634ABC9
type: Region Annotation
comment: HEPN-like fold 2
range: 18919632699733038tt947tt1159

18919632699733038tt947
type: Position
type: ExactPosition
position: 947
reference: C7NBY4-1

SIPE69D8AF46E0E6DD8
type: Region Annotation
comment: Binds crRNA repeat
range: 18919632699733038tt962tt963

18919632699733038tt962
type: Position
type: ExactPosition
position: 962
reference: C7NBY4-1

18919632699733038tt963
type: Position
type: ExactPosition
position: 963
reference: C7NBY4-1

SIPBA36F3B067F23920
type: Region Annotation
comment: Binds 3'-end of target RNA, in adjacent protein
range: 18919632699733038tt995tt998

18919632699733038tt995
type: Position
type: ExactPosition
position: 995
reference: C7NBY4-1

18919632699733038tt998
type: Position
type: ExactPosition
position: 998
reference: C7NBY4-1

SIP898EC48559777515
type: Region Annotation
comment: Binds crRNA processing site
range: 18919632699733038tt1072tt1082

18919632699733038tt1072
type: Position
type: ExactPosition
position: 1072
reference: C7NBY4-1

18919632699733038tt1082
type: Position
type: ExactPosition
position: 1082
reference: C7NBY4-1

SIPE477E27E4CA5E18B
type: Region Annotation
comment: Binds crRNA processing site
range: 18919632699733038tt1104tt1108

18919632699733038tt1104
type: Position
type: ExactPosition
position: 1104
reference: C7NBY4-1

18919632699733038tt1108
type: Position
type: ExactPosition
position: 1108
reference: C7NBY4-1

18919632699733038tt880
type: Position
type: ExactPosition
position: 880
reference: C7NBY4-1

SIPAEC73D3DFEE754CD
type: Active Site Annotation
comment: For target RNA cleavage
range: 18919632699733038tt472tt472

18919632699733038tt472
type: Position
type: ExactPosition
position: 472
reference: C7NBY4-1

SIP5115BF22257822F8
type: Active Site Annotation
comment: For target RNA cleavage
range: 18919632699733038tt477tt477

18919632699733038tt477
type: Position
type: ExactPosition
position: 477
reference: C7NBY4-1

SIP9ACBC202E4F1CB84
type: Active Site Annotation
comment: For target RNA cleavage
range: 18919632699733038tt1048tt1048

18919632699733038tt1048
type: Position
type: ExactPosition
position: 1048
reference: C7NBY4-1

SIP85C84E39A37FC267
type: Active Site Annotation
comment: For target RNA cleavage
range: 18919632699733038tt1053tt1053

18919632699733038tt1053
type: Position
type: ExactPosition
position: 1053
reference: C7NBY4-1

SIP2369BC816D347CB3
type: Site Annotation
comment: Binds target RNA
range: 18919632699733038tt41tt41

18919632699733038tt41
type: Position
type: ExactPosition
position: 41
reference: C7NBY4-1

SIPCB4FE7790CE71272
type: Site Annotation
comment: Binds 3' nucleotide of the target RNA PFS
range: 18919632699733038tt47tt47

18919632699733038tt47
type: Position
type: ExactPosition
position: 47
reference: C7NBY4-1

SIPCD05D32112C65598
type: Site Annotation
comment: Binds target RNA
range: 18919632699733038tt86tt86

18919632699733038tt86
type: Position
type: ExactPosition
position: 86
reference: C7NBY4-1

SIPDAC845EAB2108BC8
type: Site Annotation
comment: Binds crRNA repeat
range: 18919632699733038tt245tt245

18919632699733038tt245
type: Position
type: ExactPosition
position: 245
reference: C7NBY4-1

SIPBA0CA6A91DBE98CD
type: Site Annotation
comment: Binds crRNA repeat
range: 18919632699733038tt377tt377

18919632699733038tt377
type: Position
type: ExactPosition
position: 377
reference: C7NBY4-1

SIP31BAAFFC28BC1ED8
type: Site Annotation
comment: Binds 3'-end of target RNA, in adjacent protein
range: 18919632699733038tt473tt473

18919632699733038tt473
type: Position
type: ExactPosition
position: 473
reference: C7NBY4-1

SIP32D9F456EEEB71B4
type: Site Annotation
comment: Binds crRNA spacer
range: 18919632699733038tt601tt601

18919632699733038tt601
type: Position
type: ExactPosition
position: 601
reference: C7NBY4-1

SIP683A4992C095A00B
type: Site Annotation
comment: Binds target RNA
range: 18919632699733038tt659tt659

18919632699733038tt659
type: Position
type: ExactPosition
position: 659
reference: C7NBY4-1

SIPCF7CB0D7EDC758E6
type: Site Annotation
comment: Binds crRNA spacer
range: 18919632699733038tt771tt771

18919632699733038tt771
type: Position
type: ExactPosition
position: 771
reference: C7NBY4-1

SIPF67AD3906EFB2CEF
type: Site Annotation
comment: Binds crRNA spacer
range: 18919632699733038tt901tt901

18919632699733038tt901
type: Position
type: ExactPosition
position: 901
reference: C7NBY4-1

SIP9017AAAD6E5DC5F6
type: Site Annotation
comment: Binds target RNA
range: 18919632699733038tt904tt904

18919632699733038tt904
type: Position
type: ExactPosition
position: 904
reference: C7NBY4-1

SIP3F4AC8E2000FA2BE
type: Site Annotation
comment: Binds target RNA
range: 18919632699733038tt1135tt1135

18919632699733038tt1135
type: Position
type: ExactPosition
position: 1135
reference: C7NBY4-1

SIP5DE0D935EAD6078D
type: Mutagenesis Annotation
comment: Decreased cleavage of target RNA.
substitution: A
range: 18919632699733038tt2tt2

18919632699733038tt2
type: Position
type: ExactPosition
position: 2
reference: C7NBY4-1

SIP4FC755BBACF65E1E
type: Mutagenesis Annotation
comment: Decreased cleavage of target RNA.
substitution: A
range: 18919632699733038tt5tt5

18919632699733038tt5
type: Position
type: ExactPosition
position: 5
reference: C7NBY4-1

SIP25E274A7F72AAFE8
type: Mutagenesis Annotation
comment: Wild-type pre-crRNA cleavage.
substitution: A
range: 18919632699733038tt299tt299

18919632699733038tt299
type: Position
type: ExactPosition
position: 299
reference: C7NBY4-1

SIP1C5290E3656664EA
type: Mutagenesis Annotation
comment: Wild-type pre-crRNA cleavage.
substitution: A
range: 18919632699733038tt310tt310

18919632699733038tt310
type: Position
type: ExactPosition
position: 310
reference: C7NBY4-1

SIP7F1BC0711153856C
type: Mutagenesis Annotation
comment: 60% pre-crRNA cleavage.
substitution: A
range: 18919632699733038tt311tt311

18919632699733038tt311
type: Position
type: ExactPosition
position: 311
reference: C7NBY4-1

SIPF08842ECC13A4EE0
type: Mutagenesis Annotation
comment: 20% pre-crRNA cleavage.
substitution: A
range: 18919632699733038tt314tt314

18919632699733038tt314
type: Position
type: ExactPosition
position: 314
reference: C7NBY4-1

SIPC620A39B0B03BD0C
type: Mutagenesis Annotation
comment: Decreased processing of pre-crRNA.
substitution: A
range: 18919632699733038tt322tt322

18919632699733038tt322
type: Position
type: ExactPosition
position: 322
reference: C7NBY4-1

SIP96BB59176B5ADA83
type: Mutagenesis Annotation
comment: Decreased cleavage of target RNA.
substitution: A
range: 18919632699733038tt371tt371

SIPA597299C51820726
type: Mutagenesis Annotation
comment: Decreased cleavage of target RNA.
substitution: A
range: 18919632699733038tt375tt375

18919632699733038tt375
type: Position
type: ExactPosition
position: 375
reference: C7NBY4-1

SIP9215AB58C0868F49
type: Mutagenesis Annotation
comment: No cleavage of target RNA, retains pre-crRNA cleavage. Still no effect on pre-crRNA cleavage; when associated with 1048-A--A-1053.
substitution: AHGIVA
range: 18919632699733038tt472tt477

SIP66BD8A3D74405044
type: Mutagenesis Annotation
comment: Decreased cleavage of target RNA.
substitution: A
range: 18919632699733038tt473tt473

SIPD2ED18089D468258
type: Mutagenesis Annotation
comment: Decreased cleavage of target RNA.
substitution: A
range: 18919632699733038tt519tt519

SIPCC7A12AA26995FE1
type: Mutagenesis Annotation
comment: Dramatically decreased cleavage of target RNA.
substitution: A
range: 18919632699733038tt558tt558

SIPACE63B63A2565240
type: Mutagenesis Annotation
comment: Decreased cleavage of target RNA.
substitution: A
range: 18919632699733038tt601tt601

SIPF35C391AE3E4F10B
type: Mutagenesis Annotation
comment: Decreased cleavage of target RNA.
substitution: A
range: 18919632699733038tt718tt718

SIPCA9A0582C79AB576
type: Mutagenesis Annotation
comment: Decreased cleavage of target RNA.
substitution: A
range: 18919632699733038tt783tt783

SIP4955AFA0E9729A3E
type: Mutagenesis Annotation
comment: Decreased cleavage of target RNA.
substitution: A
range: 18919632699733038tt809tt809

18919632699733038tt809
type: Position
type: ExactPosition
position: 809
reference: C7NBY4-1

SIP4A68334B1F1DCFC0
type: Mutagenesis Annotation
comment: Decreased cleavage of target RNA.
substitution: A
range: 18919632699733038tt845tt845

SIPCD61497DE7AF96B9
type: Mutagenesis Annotation
comment: Decreased cleavage of target RNA.
substitution: A
range: 18919632699733038tt857tt857

SIP9C69CBF7AA08CC2B
type: Mutagenesis Annotation
comment: Decreased cleavage of target RNA.
substitution: A
range: 18919632699733038tt938tt938

SIPA3D31F237BBA9C47
type: Mutagenesis Annotation
comment: Decreased cleavage of target RNA.
substitution: A
range: 18919632699733038tt942tt942

SIPE4BD6B22B7613FAC
type: Mutagenesis Annotation
comment: Decreased cleavage of target RNA.
substitution: A
range: 18919632699733038tt962tt962

SIP1089A038823B5B5A
type: Mutagenesis Annotation
comment: Nearly no cleavage of target RNA.
substitution: A
range: 18919632699733038tt963tt963

SIP174EA3CA018FCECC
type: Mutagenesis Annotation
comment: Decreased cleavage of target RNA.
substitution: A
range: 18919632699733038tt995tt995

SIP1CA0532B78C3CE71
type: Mutagenesis Annotation
comment: Decreased cleavage of target RNA.
substitution: A
range: 18919632699733038tt997tt997

18919632699733038tt997
type: Position
type: ExactPosition
position: 997
reference: C7NBY4-1

SIP73CC85F72EF3A0C4
type: Mutagenesis Annotation
comment: Decreased cleavage of target RNA.
substitution: A
range: 18919632699733038tt998tt998

SIP0209179706E11DE6
type: Mutagenesis Annotation
comment: No cleavage of target RNA, retains pre-crRNA cleavage. Still no effect on pre-crRNA cleavage; when associated with 427-A--A-477.
substitution: ANYIAA
range: 18919632699733038tt1048tt1053

SIP76096BDCC2661197
type: Mutagenesis Annotation
comment: Barely detectable pre-crRNA cleavage.
substitution: A
range: 18919632699733038tt1072tt1072

SIP66C1621F251BB7FF
type: Mutagenesis Annotation
comment: 80% pre-crRNA cleavage.
substitution: A
range: 18919632699733038tt1078tt1078

18919632699733038tt1078
type: Position
type: ExactPosition
position: 1078
reference: C7NBY4-1

SIP68A61F9F49219A1D
type: Mutagenesis Annotation
comment: Complete loss of pre-crRNA cleavage, retains target RNA cleavage. Decreased ability to activate non-specific RNA degradation when tested with a 6-spacer CRISPR array.
substitution: AA
range: 18919632699733038tt1079tt1080

18919632699733038tt1079
type: Position
type: ExactPosition
position: 1079
reference: C7NBY4-1

18919632699733038tt1080
type: Position
type: ExactPosition
position: 1080
reference: C7NBY4-1

SIPA8C7B8FF673C0D0C
type: Mutagenesis Annotation
comment: Barely detectable pre-crRNA cleavage, retains target RNA cleavage.
substitution: A
substitution: K
range: 18919632699733038tt1079tt1079

SIPD9F6A7A3694F0010
type: Mutagenesis Annotation
comment: 60% pre-crRNA cleavage.
substitution: A
range: 18919632699733038tt1080tt1080

SIP6C8ADEBD275CD74A
type: Mutagenesis Annotation
comment: Barely detectable pre-crRNA cleavage.
substitution: A
range: 18919632699733038tt1082tt1082

SIP73C1690D1116152F
type: Mutagenesis Annotation
comment: Wild-type pre-crRNA cleavage.
substitution: A
range: 18919632699733038tt1087tt1087

18919632699733038tt1087
type: Position
type: ExactPosition
position: 1087
reference: C7NBY4-1

SIPEB0799008C81B739
type: Mutagenesis Annotation
comment: Loss of pre-crRNA cleavage.
substitution: A
substitution: R
range: 18919632699733038tt1108tt1108

SIP545774880CDD9340
type: Mutagenesis Annotation
comment: Decreased cleavage of target RNA.
substitution: A
range: 18919632699733038tt1135tt1135

18919632699733038tt4
type: Position
type: ExactPosition
position: 4
reference: C7NBY4-1

18919632699733038tt6
type: Position
type: ExactPosition
position: 6
reference: C7NBY4-1

18919632699733038tt9
type: Position
type: ExactPosition
position: 9
reference: C7NBY4-1

18919632699733038tt13
type: Position
type: ExactPosition
position: 13
reference: C7NBY4-1

18919632699733038tt18
type: Position
type: ExactPosition
position: 18
reference: C7NBY4-1

18919632699733038tt22
type: Position
type: ExactPosition
position: 22
reference: C7NBY4-1

18919632699733038tt30
type: Position
type: ExactPosition
position: 30
reference: C7NBY4-1

18919632699733038tt37
type: Position
type: ExactPosition
position: 37
reference: C7NBY4-1

18919632699733038tt42
type: Position
type: ExactPosition
position: 42
reference: C7NBY4-1

18919632699733038tt45
type: Position
type: ExactPosition
position: 45
reference: C7NBY4-1

18919632699733038tt55
type: Position
type: ExactPosition
position: 55
reference: C7NBY4-1

18919632699733038tt68
type: Position
type: ExactPosition
position: 68
reference: C7NBY4-1

18919632699733038tt71
type: Position
type: ExactPosition
position: 71
reference: C7NBY4-1

18919632699733038tt107
type: Position
type: ExactPosition
position: 107
reference: C7NBY4-1

18919632699733038tt109
type: Position
type: ExactPosition
position: 109
reference: C7NBY4-1

18919632699733038tt110
type: Position
type: ExactPosition
position: 110
reference: C7NBY4-1

18919632699733038tt117
type: Position
type: ExactPosition
position: 117
reference: C7NBY4-1

18919632699733038tt125
type: Position
type: ExactPosition
position: 125
reference: C7NBY4-1

18919632699733038tt130
type: Position
type: ExactPosition
position: 130
reference: C7NBY4-1

18919632699733038tt131
type: Position
type: ExactPosition
position: 131
reference: C7NBY4-1

18919632699733038tt149
type: Position
type: ExactPosition
position: 149
reference: C7NBY4-1

18919632699733038tt155
type: Position
type: ExactPosition
position: 155
reference: C7NBY4-1

18919632699733038tt158
type: Position
type: ExactPosition
position: 158
reference: C7NBY4-1

18919632699733038tt160
type: Position
type: ExactPosition
position: 160
reference: C7NBY4-1

18919632699733038tt163
type: Position
type: ExactPosition
position: 163
reference: C7NBY4-1

18919632699733038tt165
type: Position
type: ExactPosition
position: 165
reference: C7NBY4-1

18919632699733038tt168
type: Position
type: ExactPosition
position: 168
reference: C7NBY4-1

18919632699733038tt178
type: Position
type: ExactPosition
position: 178
reference: C7NBY4-1

18919632699733038tt182
type: Position
type: ExactPosition
position: 182
reference: C7NBY4-1

18919632699733038tt184
type: Position
type: ExactPosition
position: 184
reference: C7NBY4-1

18919632699733038tt185
type: Position
type: ExactPosition
position: 185
reference: C7NBY4-1

18919632699733038tt199
type: Position
type: ExactPosition
position: 199
reference: C7NBY4-1

18919632699733038tt202
type: Position
type: ExactPosition
position: 202
reference: C7NBY4-1

18919632699733038tt213
type: Position
type: ExactPosition
position: 213
reference: C7NBY4-1

18919632699733038tt216
type: Position
type: ExactPosition
position: 216
reference: C7NBY4-1

18919632699733038tt218
type: Position
type: ExactPosition
position: 218
reference: C7NBY4-1

18919632699733038tt221
type: Position
type: ExactPosition
position: 221
reference: C7NBY4-1

18919632699733038tt230
type: Position
type: ExactPosition
position: 230
reference: C7NBY4-1

18919632699733038tt239
type: Position
type: ExactPosition
position: 239
reference: C7NBY4-1

18919632699733038tt241
type: Position
type: ExactPosition
position: 241
reference: C7NBY4-1

18919632699733038tt250
type: Position
type: ExactPosition
position: 250
reference: C7NBY4-1

18919632699733038tt254
type: Position
type: ExactPosition
position: 254
reference: C7NBY4-1

18919632699733038tt260
type: Position
type: ExactPosition
position: 260
reference: C7NBY4-1

18919632699733038tt266
type: Position
type: ExactPosition
position: 266
reference: C7NBY4-1

18919632699733038tt278
type: Position
type: ExactPosition
position: 278
reference: C7NBY4-1

18919632699733038tt280
type: Position
type: ExactPosition
position: 280
reference: C7NBY4-1

18919632699733038tt285
type: Position
type: ExactPosition
position: 285
reference: C7NBY4-1

18919632699733038tt307
type: Position
type: ExactPosition
position: 307
reference: C7NBY4-1

18919632699733038tt320
type: Position
type: ExactPosition
position: 320
reference: C7NBY4-1

18919632699733038tt324
type: Position
type: ExactPosition
position: 324
reference: C7NBY4-1

18919632699733038tt326
type: Position
type: ExactPosition
position: 326
reference: C7NBY4-1

18919632699733038tt354
type: Position
type: ExactPosition
position: 354
reference: C7NBY4-1

18919632699733038tt363
type: Position
type: ExactPosition
position: 363
reference: C7NBY4-1

18919632699733038tt380
type: Position
type: ExactPosition
position: 380
reference: C7NBY4-1

18919632699733038tt393
type: Position
type: ExactPosition
position: 393
reference: C7NBY4-1

18919632699733038tt409
type: Position
type: ExactPosition
position: 409
reference: C7NBY4-1

18919632699733038tt411
type: Position
type: ExactPosition
position: 411
reference: C7NBY4-1

18919632699733038tt414
type: Position
type: ExactPosition
position: 414
reference: C7NBY4-1

18919632699733038tt417
type: Position
type: ExactPosition
position: 417
reference: C7NBY4-1