F8C4X8
type: Protein
reviewed: true
created: 2020-06-17
modified: 2023-05-03
version: 50
mnemonic: UGA4E_THEGP
citation: http://purl.uniprot.org/citations/23580711
citation: SIP9F8E652A8306C943
recommended name: SIP4D75E5F70F84B959
alternative name: SIPACE9EC0E5A88E8ED
enzyme: http://purl.uniprot.org/enzyme/5.1.3.6
organism: http://purl.uniprot.org/taxonomy/795359
annotation: SIP6988DC315899CC21
annotation: SIP4D4F1E2EA8AAD747
annotation: SIP87ADACB191DFBC9F
annotation: SIP746883CD70555AE0
annotation: PRO_0000450328
annotation: SIP75B2CEBD8BFE8BAA
annotation: SIPA3073092F7F2AA33
annotation: SIP3D13A32F65D467AD
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/413
classified with: http://purl.uniprot.org/keywords/520
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0050378
sequence: F8C4X8-1
proteome: Chromosome

F8C4X8-citation-23580711
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

OPF15
type: Strain

F8C4X8-citation-SIP9F8E652A8306C943
type: Citation Statement
scope: FUNCTION
scope: CATALYTIC ACTIVITY

COG0451
type: Resource
database: eggNOG
comment: Bacteria

http://purl.uniprot.org/gene3d/3.40.50.720
type: Resource
database: Gene3D
comment: NAD(P)-binding Rossmann-like Domain
signature sequence match: Gene3D 3.40.50.720 match 1

IPR016040
type: Resource
database: InterPro
comment: NAD(P)-bd_dom

IPR036291
type: Resource
database: InterPro
comment: NAD(P)-bd_dom_sf

PTHR43574
type: Resource
database: PANTHER
comment: EPIMERASE-RELATED
signature sequence match: PANTHER PTHR43574 match 1

PTHR43574:SF86
type: Resource
database: PANTHER
comment: UDP-GLUCOSE 4-EPIMERASE/UDP-SULFOQUINOVOSE SYNTHASE
signature sequence match: PANTHER PTHR43574:SF86 match 1

PF16363
type: Resource
database: Pfam
comment: GDP_Man_Dehyd
signature sequence match: Pfam PF16363 match 1

PR01713
type: Resource
database: PRINTS
comment: NUCEPIMERASE

SSF51735
type: Resource
database: SUPFAM
comment: NAD(P)-binding Rossmann-fold domains
signature sequence match: SUPFAM SSF51735 match 1

SIP4D75E5F70F84B959
type: Structured Name
full name: UDP-glucuronate 4-epimerase
short name: UGA4E
ec name: 5.1.3.6

SIPACE9EC0E5A88E8ED
type: Structured Name
full name: TgUGAE

http://purl.uniprot.org/uniprot/F8C4X8#gene-MD5CDDDE679C924CB6D536F95A70726933D
type: Gene
locus name: TOPB45_0660

SIP6988DC315899CC21
type: Function Annotation
comment: Catalyzes the interconversion of UDP-D-glucuronic acid (UDP-GlcA) and UDP-D-galacturonic acid (UDP-GalA).

SIP746883CD70555AE0
type: Similarity Annotation
comment: Belongs to the NAD(P)-dependent epimerase/dehydratase family.

PRO_0000450328
type: Chain Annotation
comment: UDP-glucuronate 4-epimerase
mass: 36622
range: 19765109661906990tt1tt323

19765109661906990tt1
type: Position
type: ExactPosition
position: 1
reference: F8C4X8-1

19765109661906990tt323
type: Position
type: ExactPosition
position: 323
reference: F8C4X8-1

SIP75B2CEBD8BFE8BAA
type: Active Site Annotation
comment: Proton acceptor
range: 19765109661906990tt152tt152

19765109661906990tt152
type: Position
type: ExactPosition
position: 152
reference: F8C4X8-1

19765109661906990tt11
type: Position
type: ExactPosition
position: 11
reference: F8C4X8-1

19765109661906990tt13
type: Position
type: ExactPosition
position: 13
reference: F8C4X8-1

19765109661906990tt156
type: Position
type: ExactPosition
position: 156
reference: F8C4X8-1

F8C4X8-1
type: Simple Sequence
modified: 2011-09-21
version: 1
mass: 36622
value: MGYYLVTGVAGFIGWRVGEFLLKEGKAVLGVDNLNDAYDVTLKYWRLNELKKSENFKFYQIDITNFQALKTIFETYSISAVIHLAARAGVRASLENPWVYVDSNITGTLNLLELMKDFGVKKLVLASTSSIYAGQSPPFHEDLKVDTPLSPYAATKKGAELLSYTYHHLYGLDISVVRYFTVYGPAGRPDMSIFRFIKWIYEEKPIKIFGDGTQARDFTYIDDIARGTIASLKPLGYEIINLGGGKNPISINQIIEILERLIGKKAKREYLNFHKADVKVTWADISKAKKLLNWEPEISIEEGLKRTVNWSKENIELIKSIKV

http://purl.uniprot.org/uniprot/F8C4X8#attribution-A61F4A6A737890EE3C212CD02F88115A
manual: true
evidence: ECO_0000250
source: Q14376

http://purl.uniprot.org/uniprot/F8C4X8#attribution-F30D5D2364152B4884D962F38A3EFF0F
manual: true
evidence: ECO_0000269
source: SIP9F8E652A8306C943

http://purl.uniprot.org/uniprot/F8C4X8#attribution-64B09CA79977E2C73EAD76023273E7B7
manual: true
evidence: ECO_0000303
source: SIP9F8E652A8306C943

http://purl.uniprot.org/uniprot/F8C4X8#attribution-46A715371B1FAFFBFBAF1720E489FC8D
manual: true
evidence: ECO_0000305

http://purl.uniprot.org/uniprot/F8C4X8#attribution-6C132688F73DB3AB6ED2BC8239FD0045
manual: true
evidence: ECO_0000312
source: AEH22762.1