P31072
type: Protein
reviewed: true
created: 1993-07-01
modified: 2023-02-22
version: 121
mnemonic: 6PGD_TRYBB
citation: http://purl.uniprot.org/citations/8426618
citation: http://purl.uniprot.org/citations/9737929
recommended name: SIP3657B0289587B303
enzyme: http://purl.uniprot.org/enzyme/1.1.1.44
organism: http://purl.uniprot.org/taxonomy/5702
annotation: SIPFFDDBD59679077E1
annotation: SIP6502C528364E371F
annotation: SIP08B02BD5C9C61781
annotation: SIP2EDDE6EC53D8543C
annotation: SIPD4D315671E61E071
annotation: PRO_0000090071
annotation: SIP4190A77BA1B2D3B1
annotation: SIP5006463225D5AAC5
annotation: SIP89E2C35702B70C96
annotation: SIP283E6E4720B43581
annotation: SIPB7084FB3FC000C19
annotation: SIP7C73FEFDA97980BA
annotation: SIPA97A3A73F0DC6A65
annotation: SIP47C8C741656EBDE6
annotation: SIP82071AF145D542D1
annotation: SIP4A76E526BF5D3BA7
annotation: SIP2F750BE57ABE1549
annotation: SIP6E20277A0AD75B68
annotation: SIPAA4E4A314CFB3795
annotation: SIP761054E1776BA1F2
annotation: SIP97CFBF3A0DBF711B
annotation: SIP7C5F7D2DEB46A33A
annotation: SIPD91D3D70BC15AC12
annotation: SIP87403AB660F2397A
annotation: SIPF952A85E1CA0F2BE
annotation: SIP13968F0D2A898C7B
annotation: SIP4F94A0BBFCC9E562
annotation: SIP12BB07596262A5CF
annotation: SIP7D814408E3EE6939
annotation: SIP1CDB7108C945D460
annotation: SIP2B14ACB1969D47AD
annotation: SIPF76207C680D41433
annotation: SIPCEDFD2549636CC35
annotation: SIPAB324CAC6E7FD7F1
annotation: SIPC1319C99A0328966
annotation: SIP22E67AF018002109
annotation: SIP65EA1D36D6EAADC9
annotation: SIP6D3DAD0ADD21C49E
annotation: SIP815EFE93240D7E7C
annotation: SIP7A378CEDA107FEFA
annotation: SIP92ED74FECE23D9E9
annotation: SIP4D344CE400CE1947
annotation: SIPD25F0E4B04976A3C
annotation: SIPBF2468B51225E37F
annotation: SIP682B0C6EE9F5740C
annotation: SIP12FB54A7E834D7B0
annotation: SIP784CC96253F30E3D
annotation: SIP3CEBF105456F2321
annotation: SIP6740EA900344B8D0
annotation: SIPBC9BBF004F251F88
annotation: SIP36D7B03782E3EF9A
annotation: SIPFF8567044F183F27
annotation: SIPAE19526F03E2E651
annotation: SIP955B518365B75352
annotation: SIP4EDDACE7E6EF9437
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/311
classified with: http://purl.uniprot.org/keywords/521
classified with: http://purl.uniprot.org/keywords/560
classified with: http://purl.uniprot.org/keywords/570
classified with: GO_0097014
classified with: GO_0005737
classified with: GO_0020015
classified with: GO_0050661
classified with: GO_0004616
classified with: GO_0019521
classified with: GO_0006098
sequence: P31072-1

P31072-citation-8426618
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

427
type: Strain

P31072-citation-9737929
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS)
scope: SUBUNIT

1PGJ
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.82
chain sequence mapping: PDB 1PGJ tt2tt479

PDB 1PGJ tt2tt479
chain: A/B=2-479

http://purl.uniprot.org/brenda/1.1.1.44
type: Resource
database: BRENDA
comment: 6519

http://purl.uniprot.org/gene3d/1.20.5.320
type: Resource
database: Gene3D
comment: 6-Phosphogluconate Dehydrogenase, domain 3
signature sequence match: Gene3D 1.20.5.320 match 1

http://purl.uniprot.org/gene3d/3.40.50.720
type: Resource
database: Gene3D
comment: NAD(P)-binding Rossmann-like Domain
signature sequence match: Gene3D 3.40.50.720 match 1
signature sequence match: Gene3D 3.40.50.720 match 2

IPR008927
type: Resource
database: InterPro
comment: 6-PGluconate_DH-like_C_sf

IPR013328
type: Resource
database: InterPro
comment: 6PGD_dom2

IPR006114
type: Resource
database: InterPro
comment: 6PGDH_C

IPR006113
type: Resource
database: InterPro
comment: 6PGDH_Gnd/GntZ

IPR006115
type: Resource
database: InterPro
comment: 6PGDH_NADP-bd

IPR006184
type: Resource
database: InterPro
comment: 6PGdom_BS

IPR036291
type: Resource
database: InterPro
comment: NAD(P)-bd_dom_sf

IPR006183
type: Resource
database: InterPro
comment: Pgluconate_DH

PTHR11811
type: Resource
database: PANTHER
comment: 6-PHOSPHOGLUCONATE DEHYDROGENASE
signature sequence match: PANTHER PTHR11811 match 1

PTHR11811:SF25
type: Resource
database: PANTHER
comment: 6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING
signature sequence match: PANTHER PTHR11811:SF25 match 1

PF00393
type: Resource
database: Pfam
comment: 6PGD
signature sequence match: Pfam PF00393 match 1

PF03446
type: Resource
database: Pfam
comment: NAD_binding_2
signature sequence match: Pfam PF03446 match 1

PIRSF000109
type: Resource
database: PIRSF
comment: 6PGD
signature sequence match: PIRSF PIRSF000109 match 1

PR00076
type: Resource
database: PRINTS
comment: 6PGDHDRGNASE

SM01350
type: Resource
database: SMART
comment: 6PGD
signature sequence match: SMART SM01350 match 1

SSF48179
type: Resource
database: SUPFAM
comment: 6-phosphogluconate dehydrogenase C-terminal domain-like
signature sequence match: SUPFAM SSF48179 match 1

SSF51735
type: Resource
database: SUPFAM
comment: NAD(P)-binding Rossmann-fold domains
signature sequence match: SUPFAM SSF51735 match 1

TIGR00873
type: Resource
database: TIGRFAMs
comment: gnd
signature sequence match: TIGRFAMs TIGR00873 match 1

PS00461
type: Resource
database: PROSITE
comment: 6PGD
signature sequence match: PROSITE PS00461 match 1

SIP3657B0289587B303
type: Structured Name
full name: 6-phosphogluconate dehydrogenase, decarboxylating
ec name: 1.1.1.44

GND
type: Gene

SIPFFDDBD59679077E1
type: Function Annotation
comment: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.

SIP2EDDE6EC53D8543C
type: Subunit Annotation
comment: Homodimer.

SIPD4D315671E61E071
type: Similarity Annotation
comment: Belongs to the 6-phosphogluconate dehydrogenase family.

PRO_0000090071
type: Chain Annotation
comment: 6-phosphogluconate dehydrogenase, decarboxylating
mass: 52154
range: 22574284492190254tt1tt479

22574284492190254tt1
type: Position
type: ExactPosition
position: 1
reference: P31072-1

22574284492190254tt479
type: Position
type: ExactPosition
position: 479
reference: P31072-1

SIP4190A77BA1B2D3B1
type: Active Site Annotation
comment: Proton acceptor
range: 22574284492190254tt186tt186

22574284492190254tt186
type: Position
type: ExactPosition
position: 186
reference: P31072-1

SIP5006463225D5AAC5
type: Active Site Annotation
comment: Proton donor
range: 22574284492190254tt193tt193

22574284492190254tt193
type: Position
type: ExactPosition
position: 193
reference: P31072-1

22574284492190254tt9
type: Position
type: ExactPosition
position: 9
reference: P31072-1

22574284492190254tt14
type: Position
type: ExactPosition
position: 14
reference: P31072-1

22574284492190254tt32
type: Position
type: ExactPosition
position: 32
reference: P31072-1

22574284492190254tt34
type: Position
type: ExactPosition
position: 34
reference: P31072-1

22574284492190254tt77
type: Position
type: ExactPosition
position: 77
reference: P31072-1

22574284492190254tt79
type: Position
type: ExactPosition
position: 79
reference: P31072-1

22574284492190254tt105
type: Position
type: ExactPosition
position: 105
reference: P31072-1

SIPA97A3A73F0DC6A65
type: Binding Site Annotation
comment: in other chain
ligand: SIPF206289925144A3B
range: 22574284492190254tt105tt105

SIP47C8C741656EBDE6
type: Binding Site Annotation
comment: in other chain
ligand: SIPF206289925144A3B
range: 22574284492190254tt131tt133

22574284492190254tt131
type: Position
type: ExactPosition
position: 131
reference: P31072-1

22574284492190254tt133
type: Position
type: ExactPosition
position: 133
reference: P31072-1

SIP82071AF145D542D1
type: Binding Site Annotation
comment: in other chain
ligand: SIPF206289925144A3B
range: 22574284492190254tt189tt190

22574284492190254tt189
type: Position
type: ExactPosition
position: 189
reference: P31072-1

22574284492190254tt190
type: Position
type: ExactPosition
position: 190
reference: P31072-1

SIP4A76E526BF5D3BA7
type: Binding Site Annotation
comment: in other chain
ligand: SIPF206289925144A3B
range: 22574284492190254tt194tt194

22574284492190254tt194
type: Position
type: ExactPosition
position: 194
reference: P31072-1

SIP2F750BE57ABE1549
type: Binding Site Annotation
comment: in other chain
ligand: SIPF206289925144A3B
range: 22574284492190254tt263tt263

22574284492190254tt263
type: Position
type: ExactPosition
position: 263
reference: P31072-1

SIP6E20277A0AD75B68
type: Binding Site Annotation
comment: in other chain
ligand: SIPF206289925144A3B
range: 22574284492190254tt290tt290

22574284492190254tt290
type: Position
type: ExactPosition
position: 290
reference: P31072-1

22574284492190254tt454
type: Position
type: ExactPosition
position: 454
reference: P31072-1

22574284492190254tt460
type: Position
type: ExactPosition
position: 460
reference: P31072-1

22574284492190254tt3
type: Position
type: ExactPosition
position: 3
reference: P31072-1

22574284492190254tt8
type: Position
type: ExactPosition
position: 8
reference: P31072-1

22574284492190254tt12
type: Position
type: ExactPosition
position: 12
reference: P31072-1

22574284492190254tt23
type: Position
type: ExactPosition
position: 23
reference: P31072-1

22574284492190254tt28
type: Position
type: ExactPosition
position: 28
reference: P31072-1

22574284492190254tt31
type: Position
type: ExactPosition
position: 31
reference: P31072-1

22574284492190254tt35
type: Position
type: ExactPosition
position: 35
reference: P31072-1

22574284492190254tt44
type: Position
type: ExactPosition
position: 44
reference: P31072-1

22574284492190254tt45
type: Position
type: ExactPosition
position: 45
reference: P31072-1

22574284492190254tt47
type: Position
type: ExactPosition
position: 47
reference: P31072-1

22574284492190254tt51
type: Position
type: ExactPosition
position: 51
reference: P31072-1

22574284492190254tt53
type: Position
type: ExactPosition
position: 53
reference: P31072-1

22574284492190254tt54
type: Position
type: ExactPosition
position: 54
reference: P31072-1

22574284492190254tt56
type: Position
type: ExactPosition
position: 56
reference: P31072-1

22574284492190254tt60
type: Position
type: ExactPosition
position: 60
reference: P31072-1

22574284492190254tt66
type: Position
type: ExactPosition
position: 66
reference: P31072-1

22574284492190254tt72
type: Position
type: ExactPosition
position: 72
reference: P31072-1

22574284492190254tt75
type: Position
type: ExactPosition
position: 75
reference: P31072-1

22574284492190254tt81
type: Position
type: ExactPosition
position: 81
reference: P31072-1

22574284492190254tt93
type: Position
type: ExactPosition
position: 93
reference: P31072-1

22574284492190254tt99
type: Position
type: ExactPosition
position: 99
reference: P31072-1

22574284492190254tt102
type: Position
type: ExactPosition
position: 102
reference: P31072-1

22574284492190254tt108
type: Position
type: ExactPosition
position: 108
reference: P31072-1

22574284492190254tt119
type: Position
type: ExactPosition
position: 119
reference: P31072-1

22574284492190254tt120
type: Position
type: ExactPosition
position: 120
reference: P31072-1

22574284492190254tt122
type: Position
type: ExactPosition
position: 122
reference: P31072-1

22574284492190254tt124
type: Position
type: ExactPosition
position: 124
reference: P31072-1

22574284492190254tt132
type: Position
type: ExactPosition
position: 132
reference: P31072-1

22574284492190254tt139
type: Position
type: ExactPosition
position: 139
reference: P31072-1

22574284492190254tt142
type: Position
type: ExactPosition
position: 142
reference: P31072-1

22574284492190254tt147
type: Position
type: ExactPosition
position: 147
reference: P31072-1

22574284492190254tt149
type: Position
type: ExactPosition
position: 149
reference: P31072-1

22574284492190254tt162
type: Position
type: ExactPosition
position: 162
reference: P31072-1

22574284492190254tt181
type: Position
type: ExactPosition
position: 181
reference: P31072-1

22574284492190254tt209
type: Position
type: ExactPosition
position: 209
reference: P31072-1

22574284492190254tt214
type: Position
type: ExactPosition
position: 214
reference: P31072-1

22574284492190254tt226
type: Position
type: ExactPosition
position: 226
reference: P31072-1

22574284492190254tt233
type: Position
type: ExactPosition
position: 233
reference: P31072-1

22574284492190254tt243
type: Position
type: ExactPosition
position: 243
reference: P31072-1

22574284492190254tt249
type: Position
type: ExactPosition
position: 249
reference: P31072-1

22574284492190254tt251
type: Position
type: ExactPosition
position: 251
reference: P31072-1

22574284492190254tt252
type: Position
type: ExactPosition
position: 252
reference: P31072-1

22574284492190254tt255
type: Position
type: ExactPosition
position: 255
reference: P31072-1

22574284492190254tt265
type: Position
type: ExactPosition
position: 265
reference: P31072-1

22574284492190254tt276
type: Position
type: ExactPosition
position: 276
reference: P31072-1

22574284492190254tt281
type: Position
type: ExactPosition
position: 281
reference: P31072-1

22574284492190254tt294
type: Position
type: ExactPosition
position: 294
reference: P31072-1

22574284492190254tt296
type: Position
type: ExactPosition
position: 296
reference: P31072-1

22574284492190254tt305
type: Position
type: ExactPosition
position: 305
reference: P31072-1

22574284492190254tt307
type: Position
type: ExactPosition
position: 307
reference: P31072-1

22574284492190254tt310
type: Position
type: ExactPosition
position: 310
reference: P31072-1

22574284492190254tt325
type: Position
type: ExactPosition
position: 325
reference: P31072-1

22574284492190254tt356
type: Position
type: ExactPosition
position: 356
reference: P31072-1

22574284492190254tt362
type: Position
type: ExactPosition
position: 362
reference: P31072-1

22574284492190254tt367
type: Position
type: ExactPosition
position: 367
reference: P31072-1

22574284492190254tt370
type: Position
type: ExactPosition
position: 370
reference: P31072-1

22574284492190254tt373
type: Position
type: ExactPosition
position: 373
reference: P31072-1

22574284492190254tt380
type: Position
type: ExactPosition
position: 380
reference: P31072-1

22574284492190254tt389
type: Position
type: ExactPosition
position: 389
reference: P31072-1

22574284492190254tt398
type: Position
type: ExactPosition
position: 398
reference: P31072-1

22574284492190254tt400
type: Position
type: ExactPosition
position: 400
reference: P31072-1

22574284492190254tt401
type: Position
type: ExactPosition
position: 401
reference: P31072-1

22574284492190254tt421
type: Position
type: ExactPosition
position: 421
reference: P31072-1

22574284492190254tt427
type: Position
type: ExactPosition
position: 427
reference: P31072-1

22574284492190254tt439
type: Position
type: ExactPosition
position: 439
reference: P31072-1

22574284492190254tt446
type: Position
type: ExactPosition
position: 446
reference: P31072-1

22574284492190254tt458
type: Position
type: ExactPosition
position: 458
reference: P31072-1

22574284492190254tt462
type: Position
type: ExactPosition
position: 462
reference: P31072-1

22574284492190254tt471
type: Position
type: ExactPosition
position: 471
reference: P31072-1

SIPF206289925144A3B
subclass of: substrate
comment: ligand shared between dimeric partners

P31072-1
type: Simple Sequence
modified: 1993-07-01
version: 1
mass: 52154
value: MSMDVGVVGLGVMGANLALNIAEKGFKVAVFNRTYSKSEEFMKANASAPFAGNLKAFETMEAFAASLKKPRKALILVQAGAATDSTTEQLKKVFEKGDILVDTGNAHFKDQGRRAQQLEAAGLRFLGMGISGGEEGARKGPAFFPGGTLSVWEEIRPIVEAAAAKADDGRPCVTMNGSGGAGSCVKMYHNSGEYAILQIWGEVFDILRAMGLNNDEVAAVLEDWKSKNFLKSYMLDISIAAARAKDKDGSYLTEHVMDRIGSKGTGLWSAQEALEIGVPAPSLNMAVVSRQFTMYKTERQANASNAPGITQSPGYTLKNKSPSGPEIKQLYDSVCIAIISCYAQMFQCLREMDKVHNFGLNLPATIATFRAGCILQGYLLKPMTEAFEKNPNISNLMCAFQTEIRAGLQNYRDMVALITSKLEVSIPVLSASLNYVTAMFTPTLKYGQLVSLQRDVFGRHGYERVDKDGRESFQWPELQ

http://purl.uniprot.org/uniprot/P31072#attribution-F46FC9AB915EBF12BFC88349A3DE91DD
creator: GeneDB
manual: true
evidence: ECO_0000314

http://purl.uniprot.org/uniprot/P31072#attribution-923008FD57B598BE14A4797162084C4A
creator: GeneDB
manual: true
evidence: ECO_0000314
source: http://purl.uniprot.org/citations/18242729

http://purl.uniprot.org/uniprot/P31072#attribution-054DBDEFCC9B8F6C72B0D4020002FF06
creator: GeneDB
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/9920387

http://purl.uniprot.org/uniprot/P31072#attribution-F6EBA877CB706B72F6927805D930EE3A
creator: GeneDB
manual: true
evidence: ECO_0000255
source: http://purl.uniprot.org/citations/9920387

http://purl.uniprot.org/uniprot/P31072#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/P31072#attribution-6D9C9729AC067C4897940F5A6181C0A0
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/9737929

http://purl.uniprot.org/uniprot/P31072#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

P18269
type: Protein
reviewed: true
created: 1990-11-01
modified: 2023-02-22
version: 105
mnemonic: 8511_TRYCR
citation: http://purl.uniprot.org/citations/2034687
citation: http://purl.uniprot.org/citations/1695668
recommended name: SIPB98A8D4B27D46BCF
alternative name: SIP33B1797372F5EA67
alternative name: SIPF34B4F9D3E139FC7
alternative name: SIPED540CD4FE2EC696
enzyme: http://purl.uniprot.org/enzyme/3.2.1.18
organism: http://purl.uniprot.org/taxonomy/5693
annotation: SIPABBF1AB652B73B3C
annotation: SIPA7618A99F0E8FE71
annotation: SIP2A8869516459600B
annotation: SIPD0E3FAD8EDE806DF
annotation: SIPF8748A2431CE7BB2
annotation: SIPC3FC9B04E0D49507
annotation: PRO_0000012039
annotation: SIPA43D6ACC1E082367
annotation: SIP845FF0A1BE77D7F4
annotation: SIP4131061B39577A4D
existence: Evidence at Transcript Level Existence
classified with: http://purl.uniprot.org/keywords/326
classified with: http://purl.uniprot.org/keywords/677
classified with: http://purl.uniprot.org/keywords/732
classified with: GO_0052794
classified with: GO_0052795
classified with: GO_0052796
classified with: GO_0008152
sequence: P18269-1

P18269-citation-2034687
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA]

CL
type: Strain

P18269-citation-1695668
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA] OF 520-752

GH33
type: Resource
database: CAZy
comment: Glycoside Hydrolase Family 33

cd15482
type: Resource
database: CDD
comment: Sialidase_non-viral
signature sequence match: CDD cd15482 match 1

IPR013320
type: Resource
database: InterPro
comment: ConA-like_dom_sf

IPR011040
type: Resource
database: InterPro
comment: Sialidase

IPR026856
type: Resource
database: InterPro
comment: Sialidase_fam

IPR036278
type: Resource
database: InterPro
comment: Sialidase_sf

IPR008377
type: Resource
database: InterPro
comment: Sialidase_trypan

IPR021287
type: Resource
database: InterPro
comment: Trans-sialidase_CS

PTHR10628:SF27
type: Resource
database: PANTHER
comment: EXO-ALPHA-SIALIDASE
signature sequence match: PANTHER PTHR10628:SF27 match 1

PTHR10628
type: Resource
database: PANTHER
comment: SIALIDASE
signature sequence match: PANTHER PTHR10628 match 1

PF13859
type: Resource
database: Pfam
comment: BNR_3
signature sequence match: Pfam PF13859 match 1

PF11052
type: Resource
database: Pfam
comment: Tr-sialidase_C
signature sequence match: Pfam PF11052 match 1

PR01803
type: Resource
database: PRINTS
comment: TCSIALIDASE

SSF49899
type: Resource
database: SUPFAM
comment: Concanavalin A-like lectins/glucanases
signature sequence match: SUPFAM SSF49899 match 1

SSF50939
type: Resource
database: SUPFAM
comment: Sialidases
signature sequence match: SUPFAM SSF50939 match 1

SIPB98A8D4B27D46BCF
type: Structured Name
full name: Sialidase 85-1.1
ec name: 3.2.1.18

SIP33B1797372F5EA67
type: Structured Name
full name: Major 85 kDa surface antigen

SIPF34B4F9D3E139FC7
type: Structured Name
full name: Neuraminidase
short name: NA

SIPED540CD4FE2EC696
type: Structured Name
full name: SA85-1.1 protein

SA85-1.1
type: Gene

SIPABBF1AB652B73B3C
type: Function Annotation
comment: Developmentally regulated neuraminidase implicated in parasite invasion of cells. May contribute to the pathology during T.cruzi infection by cleaving sialic acid from cells of the immune system.

SIP2A8869516459600B
type: Developmental Stage Annotation
comment: Mammalian stage of parasite.

SIPD0E3FAD8EDE806DF
type: Annotation
comment: The parasite mammalian stage surface antigen exhibits extensive antigenic diversity.

SIPF8748A2431CE7BB2
type: Similarity Annotation
comment: Belongs to the glycosyl hydrolase 33 family.

22572115567196462tt1
type: Position
type: ExactPosition
position: 1
reference: P18269-1

22572115567196462tt23
type: Position
type: ExactPosition
position: 23
reference: P18269-1

PRO_0000012039
type: Chain Annotation
comment: Sialidase 85-1.1
mass: 78467
range: 22572115567196462tt24tt752

22572115567196462tt24
type: Position
type: ExactPosition
position: 24
reference: P18269-1

22572115567196462tt752
type: Position
type: ExactPosition
position: 752
reference: P18269-1

SIPA43D6ACC1E082367
type: Repeat Annotation
comment: BNR 1
range: 22572115567196462tt274tt285

22572115567196462tt274
type: Position
type: ExactPosition
position: 274
reference: P18269-1

22572115567196462tt285
type: Position
type: ExactPosition
position: 285
reference: P18269-1

SIP845FF0A1BE77D7F4
type: Repeat Annotation
comment: BNR 2
range: 22572115567196462tt319tt330

22572115567196462tt319
type: Position
type: ExactPosition
position: 319
reference: P18269-1

22572115567196462tt330
type: Position
type: ExactPosition
position: 330
reference: P18269-1

SIP4131061B39577A4D
type: Region Annotation
comment: Disordered
range: 22572115567196462tt693tt725

22572115567196462tt693
type: Position
type: ExactPosition
position: 693
reference: P18269-1

22572115567196462tt725
type: Position
type: ExactPosition
position: 725
reference: P18269-1

P18269-1
type: Simple Sequence
modified: 1996-10-01
version: 2
precursor: true
mass: 80847
value: MSRRVFASAVLLLIVVTMCCGGAATAQVGSNADASTPGSALTGAIAGEGSSSGGVEGLQRVDLFVPQKTQVLPKKGPDSSRRDSFFSPSLVSAGGVIAAFAEGHINTKNPHNESAKPFSDVVAGYIDSAWEWPTLVEKVSESTWQAHTVLGKAEGKKSLDVVLRPTTTTKGNKVFLLAGSTDLSYVNWSWREGSLELKLVVGDVTKPTSSEPTERIKWGEIKSLLNESTIAAQKGKLTEFLASGGSGVVMEDGTIVFSLMAVNEKKDGVFSLIIYSKDNGSTWSLSEGISPAKCGAPRITEWEGSLLMIVDCENDQRVYVSRDMGTTWTEAIGTLSGVGSTHNWETIGRRLAVEALITVTIEGRKVMLYTQRGYALGETETTSPLYLWVTDNNRSFFVGPVGMDNAVKGELAGALLYSDGGLHLLQRRDSGEDSVMSLSRLTEELKEIKSVLSTWSQKDVFFSSLSIPTVGLVAVLSDAAGDGRWYDEYLCLNATVTNATKVKDGFQLTEPDSRAVWSVNIPDGNVRHISLSHNFTLVASVIIEEAPSGNTPLLTAVLVDAGPEYFMRLSYTADNKWMTMLKDEKKPTTESRPWEAGKEHQVALMLQGNKASVYVDGELLGEEEVPLTGEKPLEIFAFCFGACKIDGDEEESSPKEIGKKPRVTVTNVFLYNRPLNSTEMRAIKDRIPVPTRAPEPQVKIAPKPAAPAAPAGNEETARETGDGGANGDAVSAYGRVLLPLLFLLGLWGLATA

http://purl.uniprot.org/uniprot/P18269#attribution-DC036A124EC8E88DF072B29F6D9BB9FE
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/P18269#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

P18270
type: Protein
reviewed: true
created: 1990-11-01
modified: 2023-02-22
version: 85
mnemonic: 8512_TRYCR
citation: http://purl.uniprot.org/citations/1695668
recommended name: SIPF271213EEEAA5689
alternative name: SIP33B1797372F5EA67
alternative name: SIPF34B4F9D3E139FC7
alternative name: SIP876526C3A98C3F5B
enzyme: http://purl.uniprot.org/enzyme/3.2.1.18
organism: http://purl.uniprot.org/taxonomy/5693
annotation: SIP8C1FD941A4F87514
annotation: SIP3D47E48DDB397710
annotation: SIPD8A543CF7AF024AA
annotation: SIP496525FB99A2AC0E
annotation: SIPE594A224437C83A4
annotation: PRO_0000208911
annotation: SIP40F01D3649387D96
annotation: SIP7FCA3492B46D4C0E
annotation: SIPC5D803B0C76ADC21
annotation: SIPB7399374E3CE95F9
existence: Evidence at Transcript Level Existence
classified with: http://purl.uniprot.org/keywords/326
classified with: http://purl.uniprot.org/keywords/677
classified with: GO_0052794
classified with: GO_0052795
classified with: GO_0052796
classified with: GO_0008152
sequence: P18270-1

P18270-citation-1695668
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA]

CL
type: Strain

SIPF271213EEEAA5689
type: Structured Name
full name: Sialidase 85-1.2
ec name: 3.2.1.18

SIP33B1797372F5EA67
type: Structured Name
full name: Major 85 kDa surface antigen

SIPF34B4F9D3E139FC7
type: Structured Name
full name: Neuraminidase
short name: NA

SIP876526C3A98C3F5B
type: Structured Name
full name: SA85-1.2 protein

SA85-1.2
type: Gene

SIP8C1FD941A4F87514
type: Function Annotation
comment: Developmentally regulated neuraminidase implicated in parasite invasion of cells. May contribute to the pathology during T.cruzi infection by cleaving sialic acid from cells of the immune system.

SIPD8A543CF7AF024AA
type: Developmental Stage Annotation
comment: Mammalian stage of parasite.

SIP496525FB99A2AC0E
type: Annotation
comment: The parasite mammalian stage surface antigen exhibits extensive antigenic diversity.

SIPE594A224437C83A4
type: Similarity Annotation
comment: Belongs to the glycosyl hydrolase 33 family.

PRO_0000208911
type: Chain Annotation
comment: Sialidase 85-1.2
mass: 26601
range: 22572115567259694tf1tt240

22572115567259694tt1
type: Position
type: ExactPosition
position: 1
reference: P18270-1

22572115567259694tt240
type: Position
type: ExactPosition
position: 240
reference: P18270-1

SIP40F01D3649387D96
type: Region Annotation
comment: Disordered
range: 22572115567259694tt127tt158

22572115567259694tt127
type: Position
type: ExactPosition
position: 127
reference: P18270-1

22572115567259694tt158
type: Position
type: ExactPosition
position: 158
reference: P18270-1

SIP7FCA3492B46D4C0E
type: Region Annotation
comment: Disordered
range: 22572115567259694tt221tt240

22572115567259694tt221
type: Position
type: ExactPosition
position: 221
reference: P18270-1

SIPC5D803B0C76ADC21
type: Compositional Bias Annotation
comment: Acidic residues
range: 22572115567259694tt127tt143

22572115567259694tt143
type: Position
type: ExactPosition
position: 143
reference: P18270-1

P18270-1
type: Simple Sequence
modified: 1990-11-01
version: 1
fragment: single
mass: 26601
value: EHSGDNVRHVFLNHNFTLVASVTIEEAPSEKTPLLTALLGDAEPPYFMRLSYTADNKWETISKGDKKLTTESRPWVPKKEHQVALMLQGNKASVYIDGESLGEEAPLTVETPLEPFGFCFGACDFDDDDDGGDDDDEEDSQEESSPKESSPEKIGKKPHVTVTNVFLYNRPLNPTEMRAIKDRIPVSTRAPEPQVKIAPKPVAPAAPGSLRCLAHGKYQQHRGGQLWGEPPIPNMRQRDA

http://purl.uniprot.org/uniprot/P18270#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

P18271
type: Protein
reviewed: true
created: 1990-11-01
modified: 2023-02-22
version: 82
mnemonic: 8513_TRYCR
citation: http://purl.uniprot.org/citations/1695668
recommended name: SIP681359E63E9E414C
alternative name: SIP33B1797372F5EA67
alternative name: SIPF34B4F9D3E139FC7
alternative name: SIP56BAA927EEBACC25
enzyme: http://purl.uniprot.org/enzyme/3.2.1.18
organism: http://purl.uniprot.org/taxonomy/5693
annotation: SIP45EC98BBAB0D28CE
annotation: SIPD657E6D73A8100EA
annotation: SIP5CE7AD4717519B11
annotation: SIP66B103ADFE90ACC6
annotation: SIPEC2AF3DEE2B1C821
annotation: PRO_0000208912
annotation: SIP6DF18F11C2F8B684
existence: Evidence at Transcript Level Existence
classified with: http://purl.uniprot.org/keywords/326
classified with: http://purl.uniprot.org/keywords/677
classified with: GO_0052794
classified with: GO_0052795
classified with: GO_0052796
classified with: GO_0008152
sequence: LCLNATVRNATKVKDGFQLTEPDSGVMWPVNIPDYNKRHVFLNHNFTLVASVTIEEAPSGNTPLLIAVLANTEPTHTMRILYTADNKWMTMLKDEKKPTTESGTWEPKKEHQVALMLQGNKASVYVDGELLGEEEVPLTGEKPLELFAFCFGACGEENPSQESHVTVTNVFLYNR

P18271-citation-1695668
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA]

CL
type: Strain

PF13385
type: Resource
database: Pfam
comment: Laminin_G_3
signature sequence match: Pfam PF13385 match 1

SIP681359E63E9E414C
type: Structured Name
full name: Sialidase 85-1.3
ec name: 3.2.1.18

SIP33B1797372F5EA67
type: Structured Name
full name: Major 85 kDa surface antigen

SIPF34B4F9D3E139FC7
type: Structured Name
full name: Neuraminidase
short name: NA

SIP56BAA927EEBACC25
type: Structured Name
full name: SA85-1.3 protein

SA85-1.3
type: Gene

SIP45EC98BBAB0D28CE
type: Function Annotation
comment: Developmentally regulated neuraminidase implicated in parasite invasion of cells. May contribute to the pathology during T.cruzi infection by cleaving sialic acid from cells of the immune system.

SIP5CE7AD4717519B11
type: Developmental Stage Annotation
comment: Mammalian stage of parasite.

SIP66B103ADFE90ACC6
type: Annotation
comment: The parasite mammalian stage surface antigen exhibits extensive antigenic diversity.

SIPEC2AF3DEE2B1C821
type: Similarity Annotation
comment: Belongs to the glycosyl hydrolase 33 family.

PRO_0000208912
type: Chain Annotation
comment: Sialidase 85-1.3
mass: 19552
range: 22572115567259950tf1tt175

22572115567259950tt1
type: Position
type: ExactPosition
position: 1
reference: LCLNATVRNATKVKDGFQLTEPDSGVMWPVNIPDYNKRHVFLNHNFTLVASVTIEEAPSGNTPLLIAVLANTEPTHTMRILYTADNKWMTMLKDEKKPTTESGTWEPKKEHQVALMLQGNKASVYVDGELLGEEEVPLTGEKPLELFAFCFGACGEENPSQESHVTVTNVFLYNR

22572115567259950tt175
type: Position
type: ExactPosition
position: 175
reference: LCLNATVRNATKVKDGFQLTEPDSGVMWPVNIPDYNKRHVFLNHNFTLVASVTIEEAPSGNTPLLIAVLANTEPTHTMRILYTADNKWMTMLKDEKKPTTESGTWEPKKEHQVALMLQGNKASVYVDGELLGEEEVPLTGEKPLELFAFCFGACGEENPSQESHVTVTNVFLYNR

LCLNATVRNATKVKDGFQLTEPDSGVMWPVNIPDYNKRHVFLNHNFTLVASVTIEEAPSGNTPLLIAVLANTEPTHTMRILYTADNKWMTMLKDEKKPTTESGTWEPKKEHQVALMLQGNKASVYVDGELLGEEEVPLTGEKPLELFAFCFGACGEENPSQESHVTVTNVFLYNR
type: Simple Sequence
modified: 1990-11-01
version: 1
fragment: single
mass: 19552

http://purl.uniprot.org/uniprot/P18271#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

P27131
type: Protein
reviewed: true
created: 1992-08-01
modified: 2023-02-22
version: 85
mnemonic: ACT1_NAEFO
citation: SIP22BE247183862D24
citation: http://purl.uniprot.org/citations/8768528
conflicting sequence: SIP55B0FF071FDE75BC
recommended name: SIP4C53B71B21549E45
alternative name: SIPC89BC8F36ED77BBC
enzyme: http://purl.uniprot.org/enzyme/3.6.4.-
organism: http://purl.uniprot.org/taxonomy/5763
annotation: SIPADA9DA8DAF7E8195
annotation: SIP3AB6531ADC577D48
annotation: SIP9084E4EF9F775CC2
annotation: SIPF57C62518810DCB6
annotation: PRO_0000000702
annotation: PRO_0000000703
annotation: SIP36F606DCEC8583B1
annotation: SIPE6F26103131DB9AB
annotation: SIPE6C3B7C2717698A7
existence: Evidence at Transcript Level Existence
classified with: http://purl.uniprot.org/keywords/7
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/206
classified with: http://purl.uniprot.org/keywords/378
classified with: GO_0005737
classified with: GO_0005856
classified with: GO_0005524
classified with: GO_0016787
sequence: P27131-1

SIP22BE247183862D24
type: Submission Citation
title: Cloning and characterization of two virulent-related actin genes in Naegleria fowleri.
author: Ahn J.
author: Hu W.-N.
author: Kopachik W.J.
author: Band R.N.
date: 1992-05
submitted to: EMBL/GenBank/DDBJ

P27131-citation-SIP22BE247183862D24
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE

ATCC 30894 / Lee
type: Strain

P27131-citation-8768528
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

cd00012
type: Resource
database: CDD
comment: NBD_sugar-kinase_HSP70_actin
signature sequence match: CDD cd00012 match 1

IPR004000
type: Resource
database: InterPro
comment: Actin

IPR020902
type: Resource
database: InterPro
comment: Actin/actin-like_CS

IPR004001
type: Resource
database: InterPro
comment: Actin_CS

IPR043129
type: Resource
database: InterPro
comment: ATPase_NBD

PTHR11937
type: Resource
database: PANTHER
comment: ACTIN
signature sequence match: PANTHER PTHR11937 match 1

PTHR11937:SF387
type: Resource
database: PANTHER
comment: ACTIN
signature sequence match: PANTHER PTHR11937:SF387 match 1

PF00022
type: Resource
database: Pfam
comment: Actin
signature sequence match: Pfam PF00022 match 1

PR00190
type: Resource
database: PRINTS
comment: ACTIN

SM00268
type: Resource
database: SMART
comment: ACTIN
signature sequence match: SMART SM00268 match 1

SSF53067
type: Resource
database: SUPFAM
comment: Actin-like ATPase domain
signature sequence match: SUPFAM SSF53067 match 1
signature sequence match: SUPFAM SSF53067 match 2

PS00406
type: Resource
database: PROSITE
comment: ACTINS_1
signature sequence match: PROSITE PS00406 match 1

PS00432
type: Resource
database: PROSITE
comment: ACTINS_2
signature sequence match: PROSITE PS00432 match 1

PS01132
type: Resource
database: PROSITE
comment: ACTINS_ACT_LIKE
signature sequence match: PROSITE PS01132 match 1

SIP4C53B71B21549E45
type: Structured Name
full name: Actin-1
ec name: 3.6.4.-

SIPC89BC8F36ED77BBC
type: Structured Name
full name: Actin I

SIPADA9DA8DAF7E8195
type: Function Annotation
comment: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

SIPF57C62518810DCB6
type: Similarity Annotation
comment: Belongs to the actin family.

PRO_0000000702
type: Propeptide Annotation
comment: Removed in mature form
range: 22573210766881070tt1tt2

22573210766881070tt1
type: Position
type: ExactPosition
position: 1
reference: P27131-1

22573210766881070tt2
type: Position
type: ExactPosition
position: 2
reference: P27131-1

PRO_0000000703
type: Chain Annotation
comment: Actin-1
mass: 41494
range: 22573210766881070tt3tt375

22573210766881070tt3
type: Position
type: ExactPosition
position: 3
reference: P27131-1

22573210766881070tt375
type: Position
type: ExactPosition
position: 375
reference: P27131-1

SIP36F606DCEC8583B1
type: Modified Residue Annotation
comment: N-acetylaspartate
range: 22573210766881070tt3tt3

SIPE6F26103131DB9AB
type: Sequence Conflict Annotation
conflicting sequence: SIP55B0FF071FDE75BC
substitution: A
range: 22573210766881070tt58tt58

22573210766881070tt58
type: Position
type: ExactPosition
position: 58
reference: P27131-1

SIPE6C3B7C2717698A7
type: Sequence Conflict Annotation
conflicting sequence: SIP55B0FF071FDE75BC
substitution: S
range: 22573210766881070tt278tt278

22573210766881070tt278
type: Position
type: ExactPosition
position: 278
reference: P27131-1

P27131-1
type: Simple Sequence
modified: 1995-11-01
version: 2
precursor: true
mass: 41728
value: MCDDVQALVVDNGSGMCKAGFAGDDAPRAVFPSIIGRPKQKSIMVGMGNKDAYVGDEVQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFSVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILMERGYSFNTTAEREIVRDIKEKLCYIALDFEQEMKIAAESSSVEKSYELPDGNVITVGNERFRCPEVLFQPNFIGMEAAGVHETTFNSIGKCDIDIRKDLYGNVVLSGGTTMFEGIAERMTKELTNMAPASMKIKVVAPPERKYSVWIGGSILASLSTFQQMWITKEEYEDAGPGIVHRKSF

http://purl.uniprot.org/uniprot/P27131#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/P27131#attribution-34D1610EF41644C907FC0B772132761B
manual: true
evidence: ECO_0000250
source: Q8I4X0

http://purl.uniprot.org/uniprot/P27131#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

Q9NJV4
type: Protein
reviewed: true
created: 2004-01-16
modified: 2023-02-22
version: 62
mnemonic: ACT1_NAEPR
old mnemonic: ACT1_NAEGR
citation: SIPDD349687A70B31F8
recommended name: SIP4C53B71B21549E45
enzyme: http://purl.uniprot.org/enzyme/3.6.4.-
organism: http://purl.uniprot.org/taxonomy/234921
annotation: SIP66FB9D7287B73673
annotation: SIP8ABBA28533FF0214
annotation: SIP6437FBB0E92B4621
annotation: SIP3FBD6DE485E76DE7
annotation: PRO_0000088966
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/206
classified with: http://purl.uniprot.org/keywords/378
classified with: GO_0005737
classified with: GO_0005856
classified with: GO_0005524
classified with: GO_0016787
sequence: Q9NJV4-1

SIPDD349687A70B31F8
type: Submission Citation
title: The regulation of actin gene expression during Naegleria differentiation.
author: Lee J.H.
date: 1998-09
submitted to: EMBL/GenBank/DDBJ

Q9NJV4-citation-SIPDD349687A70B31F8
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

ATCC 30961 / NB-1
type: Strain

SIP4C53B71B21549E45
type: Structured Name
full name: Actin-1
ec name: 3.6.4.-

ACT1
type: Gene

SIP66FB9D7287B73673
type: Function Annotation
comment: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

SIP3FBD6DE485E76DE7
type: Similarity Annotation
comment: Belongs to the actin family.

PRO_0000088966
type: Chain Annotation
comment: Actin-1
mass: 41568
range: 22862481530958894tt1tt374

22862481530958894tt1
type: Position
type: ExactPosition
position: 1
reference: Q9NJV4-1

22862481530958894tt374
type: Position
type: ExactPosition
position: 374
reference: Q9NJV4-1

Q9NJV4-1
type: Simple Sequence
modified: 2000-10-01
version: 1
mass: 41568
value: MEEHQALVIDNGSGMCKAGFAGEDAPRAVFPSLIGRPLQRSIMVGMGNKDAYVGDEAMSKKGILALKYPIEHGIITNWDDMEKIWHHTFYNELRVGPEEHGVLLTEAPLNPKANREKMTQIMFETFRVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILMERGYSFNTSAEREIVRDIKEKLCYIAFDFEGEMKKASESTAVDTSYELPDGNIITIGNERFRCPEVLFQPNFIGMEAAGVHETAFNSIGKCDIDIRKDLYSNVVLSGGTTMFEGIAERMTKELTAMAPASMKIRVVAPPERKYSVWIGGSILSSLSTFQSMWITAEEYEDAGCGIVHRKCF

http://purl.uniprot.org/uniprot/Q9NJV4#attribution-34D1610EF41644C907FC0B772132761B
manual: true
evidence: ECO_0000250
source: Q8I4X0

http://purl.uniprot.org/uniprot/Q9NJV4#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

P12432
type: Protein
reviewed: true
created: 1989-10-01
modified: 2023-02-22
version: 83
mnemonic: ACT1_TRYBB
old mnemonic: ACT1_TRYBR
citation: http://purl.uniprot.org/citations/3386635
recommended name: SIPA6F273B20761331B
enzyme: http://purl.uniprot.org/enzyme/3.6.4.-
organism: http://purl.uniprot.org/taxonomy/5702
annotation: SIP1B9956E47AB11811
annotation: SIPC11149B0C2B37560
annotation: SIP21412E347B70212F
annotation: SIP1D57BF5E42FF5825
annotation: PRO_0000089046
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/206
classified with: http://purl.uniprot.org/keywords/378
classified with: GO_0097014
classified with: GO_0005737
classified with: GO_0005856
classified with: GO_0005524
classified with: GO_0016787
sequence: P12432-1

P12432-citation-3386635
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

SIPA6F273B20761331B
type: Structured Name
full name: Actin A
ec name: 3.6.4.-

SIP1B9956E47AB11811
type: Function Annotation
comment: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

SIP1D57BF5E42FF5825
type: Similarity Annotation
comment: Belongs to the actin family.

PRO_0000089046
type: Chain Annotation
comment: Actin A
mass: 41944
range: 22572089830748718tt1tt376

22572089830748718tt1
type: Position
type: ExactPosition
position: 1
reference: P12432-1

22572089830748718tt376
type: Position
type: ExactPosition
position: 376
reference: P12432-1

P12432-1
type: Simple Sequence
modified: 1989-10-01
version: 1
mass: 41944
value: MSDEEQTAIVCDNGSGMVKSGFSGDDAPRHVFPSIVGRPKNEQAMMGSANKKLFVGDEAQAKRGVLALKYPIEHGIVTNWDDMEKVWHHTFYNELRVNPESHNVLLTEAPMNPKQNREKMTQIMFETFGVPAMYVGIQAVLSLYSSGRTTGIVLDAGDGVTHTVPIYEGYSLPHAIRRVDMAGRDLTEYLMKILMHTGMTFTTSAEKEIVRNIKEQLCYVALDFDEEMTNSAKSVSEEPFELPDGNVMQVGNQRFRCPEALFKPALIGLDEAPGFHEMTFQSINKCDIDVRRDLYGNIVLSGGTTMFKNLPERLAKEISNLPPSSIKPKVVAPPERKYSVWIGGSILSSLTTFQSMWITKSEYDESGPSIVHSKCF

http://purl.uniprot.org/uniprot/P12432#attribution-F46FC9AB915EBF12BFC88349A3DE91DD
creator: GeneDB
manual: true
evidence: ECO_0000314

http://purl.uniprot.org/uniprot/P12432#attribution-34D1610EF41644C907FC0B772132761B
manual: true
evidence: ECO_0000250
source: Q8I4X0

http://purl.uniprot.org/uniprot/P12432#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

P27132
type: Protein
reviewed: true
created: 1992-08-01
modified: 2023-02-22
version: 76
mnemonic: ACT2_NAEFO
citation: SIP22BE247183862D24
recommended name: SIPF86C10B98D3E8EA3
alternative name: SIP2ACC82949751309F
enzyme: http://purl.uniprot.org/enzyme/3.6.4.-
organism: http://purl.uniprot.org/taxonomy/5763
annotation: SIPBB74E3821C05816D
annotation: SIP143E38D0D79FC35D
annotation: SIP2250DB8C24C6AEE3
annotation: SIP9A2AA2E357A9D4F5
annotation: PRO_0000088967
annotation: SIP022A5579C6C19327
existence: Evidence at Transcript Level Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/206
classified with: http://purl.uniprot.org/keywords/378
classified with: GO_0005737
classified with: GO_0005856
classified with: GO_0005524
classified with: GO_0016787
sequence: P27132-1

P27132-citation-SIP22BE247183862D24
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA]

ATCC 30894 / Lee
type: Strain

SIPF86C10B98D3E8EA3
type: Structured Name
full name: Actin-2
ec name: 3.6.4.-

SIP2ACC82949751309F
type: Structured Name
full name: Actin II

SIPBB74E3821C05816D
type: Function Annotation
comment: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

SIP9A2AA2E357A9D4F5
type: Similarity Annotation
comment: Belongs to the actin family.

PRO_0000088967
type: Chain Annotation
comment: Actin-2
mass: 41153
range: 22573210766881326tf1tt371

22573210766881326tt1
type: Position
type: ExactPosition
position: 1
reference: P27132-1

22573210766881326tt371
type: Position
type: ExactPosition
position: 371
reference: P27132-1

P27132-1
type: Simple Sequence
modified: 1992-08-01
version: 1
fragment: single
mass: 41153
value: VQALEVDNGSGMCKAGFAGDDAPGAVFPSIIGRPKQKSIMVGMGNKDAYVGDEVQSKRGILIFKYPIQHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFSVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLIEDSHGTCYSFNTTAERECQRDIKGKALLYCFDFEQEMKIAAESSSVEKLYELPDGNVITVGNERFRCPEVLFQPNFIGMEAAGVHETTFNSIGKCDIHIRKDLYGNVVLSGGTTMFEGIAERMTKELTNMAPASMKIKVVAPPERKYSVWIGGSILASLSTFQQMWITKEEYEDAGPGIVHRESF

http://purl.uniprot.org/uniprot/P27132#attribution-34D1610EF41644C907FC0B772132761B
manual: true
evidence: ECO_0000250
source: Q8I4X0

http://purl.uniprot.org/uniprot/P27132#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

P12433
type: Protein
reviewed: true
created: 1989-10-01
modified: 2023-02-22
version: 81
mnemonic: ACT2_TRYBB
old mnemonic: ACT2_TRYBR
citation: http://purl.uniprot.org/citations/3386635
recommended name: SIP824726367EC6A1E6
enzyme: http://purl.uniprot.org/enzyme/3.6.4.-
organism: http://purl.uniprot.org/taxonomy/5702
annotation: SIPE12FCC261729F599
annotation: SIPA04C210011D0D041
annotation: SIP474B5E9A75D3B8A6
annotation: SIPCA6FCAFF11E3252A
annotation: PRO_0000089047
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/206
classified with: http://purl.uniprot.org/keywords/378
classified with: GO_0097014
classified with: GO_0005737
classified with: GO_0005856
classified with: GO_0005524
classified with: GO_0016787
sequence: P12433-1

P12433-citation-3386635
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

SIP824726367EC6A1E6
type: Structured Name
full name: Actin B
ec name: 3.6.4.-

SIPE12FCC261729F599
type: Function Annotation
comment: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

SIPCA6FCAFF11E3252A
type: Similarity Annotation
comment: Belongs to the actin family.

PRO_0000089047
type: Chain Annotation
comment: Actin B
mass: 41882
range: 22572089830748974tt1tt376

22572089830748974tt1
type: Position
type: ExactPosition
position: 1
reference: P12433-1

22572089830748974tt376
type: Position
type: ExactPosition
position: 376
reference: P12433-1

P12433-1
type: Simple Sequence
modified: 1989-10-01
version: 1
mass: 41882
value: MSDEEQTAIVCDNGSGMVKSGFSGDDAPRHLFPSIVGPPKNEQAMMGSAKQEMFVGDEAQAKRGVLALKYPIEHGIVTNWDDMEKVWHHTFYNELRVNPESHNVLLTEAPMNPKQNREKMTQIMFETFGVPAMYVGIQAVLSLYSSGRTTGIVLDAGDGVTHTVPIYEGYSLPHAIRRVDMAGRDLTEYLMKILMETGMTFTTSAQKEIVRNIKEQLCYVALDFDEEMTNSAKSVSEEPFELPDGNVMQVGNQRFRCPQALFKPALIGLDEAPGFHEMTFQSINKCDIDVRRDLYGNIVLSGGTTMFKNLPERLGKEISNLAPSSIKPKVVAPPERKYSVWIGGSILSSLTTFQSMWITKSEYDESGPSIVHSKCF

http://purl.uniprot.org/uniprot/P12433#attribution-F46FC9AB915EBF12BFC88349A3DE91DD
creator: GeneDB
manual: true
evidence: ECO_0000314

http://purl.uniprot.org/uniprot/P12433#attribution-34D1610EF41644C907FC0B772132761B
manual: true
evidence: ECO_0000250
source: Q8I4X0

http://purl.uniprot.org/uniprot/P12433#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

P45520
type: Protein
reviewed: true
created: 1995-11-01
modified: 2023-02-22
version: 72
mnemonic: ACT_LEIMA
citation: http://purl.uniprot.org/citations/8112581
recommended name: SIP7CC17EDC98B1D515
enzyme: http://purl.uniprot.org/enzyme/3.6.4.-
organism: http://purl.uniprot.org/taxonomy/5664
annotation: SIPA1D0B3DA04030F87
annotation: SIP65C545D57FDF136E
annotation: SIPFE53306266C8BFF4
annotation: SIP92D1899A0AF60EE2
annotation: PRO_0000088952
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/206
classified with: http://purl.uniprot.org/keywords/378
classified with: GO_0005737
classified with: GO_0005856
classified with: GO_0043227
classified with: GO_0005524
classified with: GO_0016787
sequence: P45520-1

P45520-citation-8112581
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE

MHOM/IR/83/Lt252 / CC-1
type: Strain

KOG0676
type: Resource
database: eggNOG
comment: Eukaryota

SIP7CC17EDC98B1D515
type: Structured Name
full name: Actin
ec name: 3.6.4.-

SIPA1D0B3DA04030F87
type: Function Annotation
comment: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

SIP92D1899A0AF60EE2
type: Similarity Annotation
comment: Belongs to the actin family.

PRO_0000088952
type: Chain Annotation
comment: Actin
mass: 41991
range: 22575401267245102tt1tt376

22575401267245102tt1
type: Position
type: ExactPosition
position: 1
reference: P45520-1

22575401267245102tt376
type: Position
type: ExactPosition
position: 376
reference: P45520-1

P45520-1
type: Simple Sequence
modified: 1995-11-01
version: 1
mass: 41991
value: MADNEQSSIVCDNGSGMVKAGFSGDDAPRHVFPSIVGRPKNMQAMMGSANKTVYVGDEAQSKRGVLSLKYPIEHGIVTNWDDMEKIWHHTFYNDVRVNPEQHNVLLTEAPMNPKQNREKMTQIMFETFNVPSLYIGIQAVLSLYSSGRTTGIVLDAGDGVTHTVPIYEGYSLPHAVRRVDMAGRDLTEYLMKIMMETGTTFTTTAEKEIVRNVKEQLCYVALDFEEEMTNSAKSANEEAFELPDGNVMMVGNQRFRCPEVLFKPSLIGLDEAPGFPEMVYQSINKCDIDVRRELYGNIVLSGGSTMFLNLPERLAKEISNLAPSSIKPKVVAPPERKYSVWIGGSILSSLTTFQTMWVKKSEYDESGPSIVHNKCF

http://purl.uniprot.org/uniprot/P45520#attribution-34D1610EF41644C907FC0B772132761B
manual: true
evidence: ECO_0000250
source: Q8I4X0

http://purl.uniprot.org/uniprot/P45520#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

P53477
type: Protein
reviewed: true
created: 1996-10-01
modified: 2023-02-22
version: 71
mnemonic: ACT_TRYCR
citation: SIP71848A8B4B137AC4
recommended name: SIP7CC17EDC98B1D515
enzyme: http://purl.uniprot.org/enzyme/3.6.4.-
organism: http://purl.uniprot.org/taxonomy/5693
annotation: SIP6128D103046458F2
annotation: SIP556A81212C2FB071
annotation: SIP756B4E03F3103691
annotation: SIP02819FA0A1C86ACE
annotation: PRO_0000089048
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/206
classified with: http://purl.uniprot.org/keywords/378
classified with: GO_0005737
classified with: GO_0005856
classified with: GO_0043227
classified with: GO_0005524
classified with: GO_0016787
sequence: P53477-1

SIP71848A8B4B137AC4
type: Submission Citation
author: Paixao J.C.
author: Silva R.
author: Rondinelli E.
date: 1995-03
submitted to: EMBL/GenBank/DDBJ

P53477-citation-SIP71848A8B4B137AC4
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

DM28C
type: Strain

SIP7CC17EDC98B1D515
type: Structured Name
full name: Actin
ec name: 3.6.4.-

SIP6128D103046458F2
type: Function Annotation
comment: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

SIP02819FA0A1C86ACE
type: Similarity Annotation
comment: Belongs to the actin family.

PRO_0000089048
type: Chain Annotation
comment: Actin
mass: 41903
range: 22576492172490542tt1tt376

22576492172490542tt1
type: Position
type: ExactPosition
position: 1
reference: P53477-1

22576492172490542tt376
type: Position
type: ExactPosition
position: 376
reference: P53477-1

P53477-1
type: Simple Sequence
modified: 1996-10-01
version: 1
mass: 41903
value: MSDEEQSAIVCDNGSGMVKAGFSGDDALCHVFPSIVGRPKNEQAMMGSASKKLFVGDEAQAKRGVLSLKYPIEHGIVTNWDDMEKIWHHTFYNDVRVNPESHSVLLTEAPMNPKQNREKMTQIMFETFGVPAMYVGIQAVLSLYSSGRTTGIVLDAGDGVTHTVPIYEGYSLPHAIRRMDMAGRDLTEYLMKLLMESGMTFTTSAEKEIVRNVKEQLCYVALDFDEEVTNSAKTVNEEPFELPDGTIMQVGNQRFRCPEALFKPMLIGLDEAPGFHEMTFQSINKCDIDVRRDLYGNIVLSGGTTMFKNLPERLGKEISNLAPSSIKPKVVAPPERKYSVWIGGSILSSLTTFQTMWIKKSEYDEAGPSIVHNKCF

http://purl.uniprot.org/uniprot/P53477#attribution-34D1610EF41644C907FC0B772132761B
manual: true
evidence: ECO_0000250
source: Q8I4X0

http://purl.uniprot.org/uniprot/P53477#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

O97157
type: Protein
reviewed: true
created: 2000-12-01
modified: 2023-02-22
version: 86
mnemonic: ADAS_TRYBB
citation: SIP33A85FA18B64A70
recommended name: SIPD4AFAF6D0B06719D
alternative name: SIPB69C6E73518CBC91
enzyme: http://purl.uniprot.org/enzyme/2.5.1.26
organism: http://purl.uniprot.org/taxonomy/5702
annotation: SIP275B1E20FD1D3DDE
annotation: SIPB8C44C5581931CDF
annotation: SIPF908C7F5CFC7FBB3
annotation: SIP73E224B0962AF239
annotation: SIPE0D4DAE678B356B0
annotation: SIP477799913BC6E64D
annotation: SIP6B20C775B72CCC80
annotation: PRO_0000128180
annotation: SIP130F61A47962A94A
annotation: SIP6092D7848000CB48
annotation: SIP7756F652E3D569A7
annotation: SIP933BF5264177A204
annotation: SIPB24FD0A3ED944B1C
annotation: SIPB4E9BB73DA7585B3
annotation: SIPA1DC43D85FB04A1E
annotation: SIP4908597EBC2C1B0F
annotation: SIP106F53C0307FFDED
annotation: SIPDF7481D585A9029D
annotation: SIPD4FB77850794F011
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/274
classified with: http://purl.uniprot.org/keywords/444
classified with: http://purl.uniprot.org/keywords/576
classified with: http://purl.uniprot.org/keywords/808
classified with: GO_0005777
classified with: GO_0008609
classified with: GO_0071949
classified with: GO_0008611
sequence: O97157-1

SIP33A85FA18B64A70
type: Submission Citation
title: Molecular characterization of Trypanosoma brucei alkyl-dihydroxyacetonephosphate synthase.
author: Zomer A.M.W.
author: Michels P.A.M.
author: Opperdoes F.R.
date: 1999-01
submitted to: EMBL/GenBank/DDBJ

O97157-citation-SIP33A85FA18B64A70
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

http://purl.uniprot.org/brenda/2.5.1.26
type: Resource
database: BRENDA
comment: 6519

http://purl.uniprot.org/gene3d/3.30.43.10
type: Resource
database: Gene3D
comment: Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2
signature sequence match: Gene3D 3.30.43.10 match 1

IPR025650
type: Resource
database: InterPro
comment: Alkyl-DHAP_Synthase

IPR016166
type: Resource
database: InterPro
comment: FAD-bd_PCMH

IPR036318
type: Resource
database: InterPro
comment: FAD-bd_PCMH-like_sf

IPR016167
type: Resource
database: InterPro
comment: FAD-bd_PCMH_sub1

IPR016169
type: Resource
database: InterPro
comment: FAD-bd_PCMH_sub2

IPR016164
type: Resource
database: InterPro
comment: FAD-linked_Oxase-like_C

IPR004113
type: Resource
database: InterPro
comment: FAD-linked_oxidase_C

IPR006094
type: Resource
database: InterPro
comment: Oxid_FAD_bind_N

IPR016171
type: Resource
database: InterPro
comment: Vanillyl_alc_oxidase_C-sub2

PTHR46568
type: Resource
database: PANTHER
comment: ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL
signature sequence match: PANTHER PTHR46568 match 1

PTHR46568:SF1
type: Resource
database: PANTHER
comment: ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL
signature sequence match: PANTHER PTHR46568:SF1 match 1

PF02913
type: Resource
database: Pfam
comment: FAD-oxidase_C
signature sequence match: Pfam PF02913 match 1

PF01565
type: Resource
database: Pfam
comment: FAD_binding_4
signature sequence match: Pfam PF01565 match 1

SSF56176
type: Resource
database: SUPFAM
comment: FAD-binding/transporter-associated domain-like
signature sequence match: SUPFAM SSF56176 match 1

SSF55103
type: Resource
database: SUPFAM
comment: FAD-linked oxidases, C-terminal domain
signature sequence match: SUPFAM SSF55103 match 1

PS51387
type: Resource
database: PROSITE
comment: FAD_PCMH
signature sequence match: PROSITE PS51387 match 1

SIPD4AFAF6D0B06719D
type: Structured Name
full name: Alkyldihydroxyacetonephosphate synthase
short name: Alkyl-DHAP synthase
ec name: 2.5.1.26

SIPB69C6E73518CBC91
type: Structured Name
full name: Alkylglycerone-phosphate synthase

SIP275B1E20FD1D3DDE
type: Function Annotation
comment: Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.

SIPE0D4DAE678B356B0
type: Subunit Annotation
comment: Homodimer.

SIP6B20C775B72CCC80
type: Similarity Annotation
comment: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.

PRO_0000128180
type: Chain Annotation
comment: Alkyldihydroxyacetonephosphate synthase
mass: 69068
range: 22299432371697454tt1tt613

22299432371697454tt1
type: Position
type: ExactPosition
position: 1
reference: O97157-1

22299432371697454tt613
type: Position
type: ExactPosition
position: 613
reference: O97157-1

SIP130F61A47962A94A
type: Domain Extent Annotation
comment: FAD-binding PCMH-type
range: 22299432371697454tt126tt307

22299432371697454tt126
type: Position
type: ExactPosition
position: 126
reference: O97157-1

22299432371697454tt307
type: Position
type: ExactPosition
position: 307
reference: O97157-1

SIP6092D7848000CB48
type: Region Annotation
comment: Important for enzyme activity
range: 22299432371697454tt534tt536

22299432371697454tt534
type: Position
type: ExactPosition
position: 534
reference: O97157-1

22299432371697454tt536
type: Position
type: ExactPosition
position: 536
reference: O97157-1

SIP7756F652E3D569A7
type: Region Annotation
comment: Disordered
range: 22299432371697454tt572tt593

22299432371697454tt572
type: Position
type: ExactPosition
position: 572
reference: O97157-1

22299432371697454tt593
type: Position
type: ExactPosition
position: 593
reference: O97157-1

SIP933BF5264177A204
type: Motif Annotation
comment: Microbody targeting signal
range: 22299432371697454tt611tt613

22299432371697454tt611
type: Position
type: ExactPosition
position: 611
reference: O97157-1

SIPB24FD0A3ED944B1C
type: Active Site Annotation
comment: Proton donor/acceptor
range: 22299432371697454tt498tt498

22299432371697454tt498
type: Position
type: ExactPosition
position: 498
reference: O97157-1

22299432371697454tt158
type: Position
type: ExactPosition
position: 158
reference: O97157-1

22299432371697454tt164
type: Position
type: ExactPosition
position: 164
reference: O97157-1

22299432371697454tt228
type: Position
type: ExactPosition
position: 228
reference: O97157-1

22299432371697454tt234
type: Position
type: ExactPosition
position: 234
reference: O97157-1

22299432371697454tt241
type: Position
type: ExactPosition
position: 241
reference: O97157-1

22299432371697454tt244
type: Position
type: ExactPosition
position: 244
reference: O97157-1

22299432371697454tt291
type: Position
type: ExactPosition
position: 291
reference: O97157-1

22299432371697454tt297
type: Position
type: ExactPosition
position: 297
reference: O97157-1

22299432371697454tt437
type: Position
type: ExactPosition
position: 437
reference: O97157-1

SIPD4FB77850794F011
type: Site Annotation
comment: Important for enzyme activity
range: 22299432371697454tt342tt342

22299432371697454tt342
type: Position
type: ExactPosition
position: 342
reference: O97157-1

substrate

O97157-1
type: Simple Sequence
modified: 1999-05-01
version: 1
mass: 69068
value: MDKRMITDAFEEIKWNGWGDTGVCIKYDEARQLPIHTNGKPMKHLLKFMKDDVLKVKGEFKIKPTPGLTKEEAIKRLPPPVVKQPFVDELRQVLSKDQIRLDAYARLTHIFGKNYRDLWRVRRGMIDRPPDAVILPNNHDDCVKIMELAQKHNVVVVPFGGGTNVTGGVEPNPFETRRMVISIDMRRMGRMLHIDTESGTAVFEVGVLGPDIDEQLSRYGFMMGHDPDSYAYSTLGGWIAARGSGAMSNKYGDIENMILAMRVVTPVGVVETPLTSRPCGVDLNAMFVGSEGAFGLVTEAVVKIERLPEVKRYEGWLFPSFEVAFTAFHTCTRKGIHPCTMRLYDEDDTRLSFAASTDSGLVSTFFSKCFKKYIATVKGWNLSKISLVVVGFEGTKAQTNCQRSELVGVFQAFGATCLGTKPGNTWQEKKYDLPYLRDFALAHNFWADVFETSVLYTDAIHCWRAVKKSFAEVMAENGKNAWIGCHTAHQYRFGCCLYFTFIGGQADENDLKIFLQVKKRAMEVMLQHRGNLTHHHGIGYEHVPWMKRYNGEGGLDAIMKFKKALDPKNICNPGKLLPSPPSEKETPKATQARQNREMMFDKMGIPGALQAHL

http://purl.uniprot.org/uniprot/O97157#attribution-68097C5C9D39FEEE8BE013645ACBBDD4
creator: UniProtKB
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/O97157#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/O97157#attribution-DC036A124EC8E88DF072B29F6D9BB9FE
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/O97157#attribution-0EFE7D6BFB814B4561576AD58D647340
manual: true
evidence: ECO_0000255
source: PRU00718

http://purl.uniprot.org/uniprot/O97157#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

Q26768
type: Protein
reviewed: true
created: 1998-07-15
modified: 2023-02-22
version: 67
mnemonic: AGI6_TRYBB
citation: http://purl.uniprot.org/citations/9127738
recommended name: SIPA24EAC1E532A8060
organism: http://purl.uniprot.org/taxonomy/5702
annotation: SIP2359DB5E97CE7E2E
annotation: SIPC7604863879BACED
annotation: PRO_0000064497
annotation: SIP242152F629050DCD
annotation: SIPDF6A898EC783F239
annotation: SIP19C8C25AD832D3E3
annotation: SIP096A990C5D406C62
annotation: SIPD6C6FAEDB0AB87AE
annotation: SIP73D961DAFDC0887B
annotation: SIPBF9B45860211E15C
annotation: SIP9115AEC0CA250789
annotation: SIP07A37A69A0E35386
annotation: SIP2BC8ED831B5C4FA3
annotation: SIP9F737F8807763A11
existence: Evidence at Transcript Level Existence
classified with: http://purl.uniprot.org/keywords/206
classified with: http://purl.uniprot.org/keywords/493
classified with: http://purl.uniprot.org/keywords/677
classified with: GO_0030863
classified with: GO_0005737
classified with: GO_0005874
classified with: GO_0015630
classified with: GO_0005509
sequence: Q26768-1

Q26768-citation-9127738
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA]

427
type: Strain

http://purl.uniprot.org/gene3d/1.10.238.10
type: Resource
database: Gene3D
comment: EF-hand
signature sequence match: Gene3D 1.10.238.10 match 1
signature sequence match: Gene3D 1.10.238.10 match 2
signature sequence match: Gene3D 1.10.238.10 match 3

IPR011992
type: Resource
database: InterPro
comment: EF-hand-dom_pair

IPR002048
type: Resource
database: InterPro
comment: EF_hand_dom

PF13833
type: Resource
database: Pfam
comment: EF-hand_8
signature sequence match: Pfam PF13833 match 1

SSF47473
type: Resource
database: SUPFAM
comment: EF-hand
signature sequence match: SUPFAM SSF47473 match 1
signature sequence match: SUPFAM SSF47473 match 2

PS50222
type: Resource
database: PROSITE
comment: EF_HAND_2
signature sequence match: PROSITE PS50222 match 1
signature sequence match: PROSITE PS50222 match 2
signature sequence match: PROSITE PS50222 match 3
signature sequence match: PROSITE PS50222 match 4
signature sequence match: PROSITE PS50222 match 5
signature sequence match: PROSITE PS50222 match 6

SIPA24EAC1E532A8060
type: Structured Name
full name: I/6 autoantigen

SIP2359DB5E97CE7E2E
type: Function Annotation
comment: Microtubule-associated protein that may be involved in cross-linking microtubules.

PRO_0000064497
type: Chain Annotation
comment: I/6 autoantigen
mass: 27765
range: 22854681549486126tt1tt243

22854681549486126tt1
type: Position
type: ExactPosition
position: 1
reference: Q26768-1

22854681549486126tt243
type: Position
type: ExactPosition
position: 243
reference: Q26768-1

SIP242152F629050DCD
type: Domain Extent Annotation
comment: EF-hand
range: 22854681549486126tt110tt145

22854681549486126tt110
type: Position
type: ExactPosition
position: 110
reference: Q26768-1

22854681549486126tt145
type: Position
type: ExactPosition
position: 145
reference: Q26768-1

SIPDF6A898EC783F239
type: Repeat Annotation
comment: 1
range: 22854681549486126tt181tt188

22854681549486126tt181
type: Position
type: ExactPosition
position: 181
reference: Q26768-1

22854681549486126tt188
type: Position
type: ExactPosition
position: 188
reference: Q26768-1

SIP19C8C25AD832D3E3
type: Repeat Annotation
comment: 2
range: 22854681549486126tt189tt196

22854681549486126tt189
type: Position
type: ExactPosition
position: 189
reference: Q26768-1

22854681549486126tt196
type: Position
type: ExactPosition
position: 196
reference: Q26768-1

SIP096A990C5D406C62
type: Repeat Annotation
comment: 3
range: 22854681549486126tt197tt204

22854681549486126tt197
type: Position
type: ExactPosition
position: 197
reference: Q26768-1

22854681549486126tt204
type: Position
type: ExactPosition
position: 204
reference: Q26768-1

SIPD6C6FAEDB0AB87AE
type: Repeat Annotation
comment: 4
range: 22854681549486126tt205tt212

22854681549486126tt205
type: Position
type: ExactPosition
position: 205
reference: Q26768-1

22854681549486126tt212
type: Position
type: ExactPosition
position: 212
reference: Q26768-1

SIP73D961DAFDC0887B
type: Repeat Annotation
comment: 5
range: 22854681549486126tt213tt220

22854681549486126tt213
type: Position
type: ExactPosition
position: 213
reference: Q26768-1

22854681549486126tt220
type: Position
type: ExactPosition
position: 220
reference: Q26768-1

SIPBF9B45860211E15C
type: Repeat Annotation
comment: 6
range: 22854681549486126tt221tt228

22854681549486126tt221
type: Position
type: ExactPosition
position: 221
reference: Q26768-1

22854681549486126tt228
type: Position
type: ExactPosition
position: 228
reference: Q26768-1

SIP9115AEC0CA250789
type: Region Annotation
comment: Disordered
range: 22854681549486126tt166tt243

22854681549486126tt166
type: Position
type: ExactPosition
position: 166
reference: Q26768-1

SIP07A37A69A0E35386
type: Region Annotation
comment: 6 X 8 AA tandem repeats
range: 22854681549486126tt181tt228

SIP2BC8ED831B5C4FA3
type: Compositional Bias Annotation
comment: Basic residues
range: 22854681549486126tt174tt192

22854681549486126tt174
type: Position
type: ExactPosition
position: 174
reference: Q26768-1

22854681549486126tt192
type: Position
type: ExactPosition
position: 192
reference: Q26768-1

SIP9F737F8807763A11
type: Compositional Bias Annotation
comment: Basic and acidic residues
range: 22854681549486126tt193tt231

22854681549486126tt193
type: Position
type: ExactPosition
position: 193
reference: Q26768-1

22854681549486126tt231
type: Position
type: ExactPosition
position: 231
reference: Q26768-1

Q26768-1
type: Simple Sequence
modified: 1996-11-01
version: 1
mass: 27765
value: MLCPPDVAFEKRHFKRRDGNKVVPPSIALVAGLESGFLFKLSAVEDVARRGQFPGLLTEDGFLLMCEESEHIRDAYAMAKHLVALAPDGIFTRATLQEAAGKVGSTQDTLSVEEVDALFNALDSDNRGYVSVDEFMDALYGEEGREAMREIRREYMRRKIEVEGEPSWRMRPTPKPTRKLRQKRKREQGQKRKQGQRQKQEQGQRQKREQGQRQKQEQGQKRKRERGGAQRPPPPKQKAGCGC

http://purl.uniprot.org/uniprot/Q26768#attribution-F46FC9AB915EBF12BFC88349A3DE91DD
creator: GeneDB
manual: true
evidence: ECO_0000314

http://purl.uniprot.org/uniprot/Q26768#attribution-A5028626F13690F7B86DF04C8841C700
creator: GeneDB
manual: true
evidence: ECO_0000314
source: http://purl.uniprot.org/citations/9127738

http://purl.uniprot.org/uniprot/Q26768#attribution-F3C748FE889710F20CBEB113D63B84DB
manual: true
evidence: ECO_0000255
source: PRU00448

G8XR08
type: Protein
reviewed: true
created: 2021-09-29
modified: 2023-05-03
version: 36
mnemonic: AGO1_LEIBR
citation: http://purl.uniprot.org/citations/21060810
citation: http://purl.uniprot.org/citations/23217017
recommended name: SIPB212B1FEFAF44DEF
organism: http://purl.uniprot.org/taxonomy/5660
annotation: SIP471A5E3987260CD0
annotation: SIPD72D8A96B9DDE1DE
annotation: SIP1868F5FBC71A5BB9
annotation: SIP4508F2839958EFF7
annotation: PRO_0000453673
annotation: SIP1F79BDAC31D355CF
annotation: SIP4873B94A509DCF36
annotation: SIPD7696242223AE8C7
annotation: SIP1DACD92040743617
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/694
classified with: http://purl.uniprot.org/keywords/943
classified with: GO_0005737
classified with: GO_0003723
classified with: GO_0031047
sequence: G8XR08-1

G8XR08-citation-21060810
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: FUNCTION
scope: DISRUPTION PHENOTYPE

MHOM/BR/75/M2903
type: Strain

G8XR08-citation-23217017
type: Citation Statement
scope: FUNCTION
scope: SUBCELLULAR LOCATION
scope: DISRUPTION PHENOTYPE

http://purl.uniprot.org/gene3d/2.170.260.10
type: Resource
database: Gene3D
comment: paz domain
signature sequence match: Gene3D 2.170.260.10 match 1

http://purl.uniprot.org/gene3d/3.30.420.10
type: Resource
database: Gene3D
comment: Ribonuclease H-like superfamily/Ribonuclease H
signature sequence match: Gene3D 3.30.420.10 match 1

IPR032472
type: Resource
database: InterPro
comment: ArgoL2

IPR003100
type: Resource
database: InterPro
comment: PAZ_dom

IPR036085
type: Resource
database: InterPro
comment: PAZ_dom_sf

IPR003165
type: Resource
database: InterPro
comment: Piwi

IPR012337
type: Resource
database: InterPro
comment: RNaseH-like_sf

IPR036397
type: Resource
database: InterPro
comment: RNaseH_sf

PTHR22891:SF174
type: Resource
database: PANTHER
comment: ARGONAUTE-1, ISOFORM A
signature sequence match: PANTHER PTHR22891:SF174 match 1

PTHR22891
type: Resource
database: PANTHER
comment: EUKARYOTIC TRANSLATION INITIATION FACTOR 2C
signature sequence match: PANTHER PTHR22891 match 1

PF16488
type: Resource
database: Pfam
comment: ArgoL2
signature sequence match: Pfam PF16488 match 1

PF02170
type: Resource
database: Pfam
comment: PAZ
signature sequence match: Pfam PF02170 match 1

SM00949
type: Resource
database: SMART
comment: PAZ
signature sequence match: SMART SM00949 match 1

SM00950
type: Resource
database: SMART
comment: Piwi
signature sequence match: SMART SM00950 match 1

SSF101690
type: Resource
database: SUPFAM
comment: PAZ domain
signature sequence match: SUPFAM SSF101690 match 1

SSF53098
type: Resource
database: SUPFAM
comment: Ribonuclease H-like
signature sequence match: SUPFAM SSF53098 match 1

PS50821
type: Resource
database: PROSITE
comment: PAZ
signature sequence match: PROSITE PS50821 match 1

SIPB212B1FEFAF44DEF
type: Structured Name
full name: Protein argonaute 1
short name: LbrAGO1

AGO1
type: Gene

SIP471A5E3987260CD0
type: Function Annotation
comment: Involved in RNA-mediated gene silencing (RNAi) of mobile elements and repeats including retroposons SLACS (Spliced Leader Associated Conserved Sequence), TATE (Telomere-Associated Transposable Element) and TAS-like sequences (Telomere Associated Sequence), and a family of 74-nucleotide long tandem repeats, CIR74 (PubMed:21060810, PubMed:23217017). Predominantly binds to siRNAs derived from SLACS and TATE transposable elements and to a lesser extent to siRNAs from TAS-like and CIR74 elements (PubMed:23217017).

SIP1868F5FBC71A5BB9
type: Disruption Phenotype Annotation
comment: RNAi-mediated knockdown reduces RNAi activity (PubMed:21060810, PubMed:23217017). Levels of mobile elements TATE, SLACS, TAS-like and repeat element CIR74 siRNAs are reduced (PubMed:23217017).

SIP4508F2839958EFF7
type: Similarity Annotation
comment: Belongs to the argonaute family.

PRO_0000453673
type: Chain Annotation
comment: Protein argonaute 1
mass: 100596
range: 20046675333625902tt1tt898

20046675333625902tt1
type: Position
type: ExactPosition
position: 1
reference: G8XR08-1

20046675333625902tt898
type: Position
type: ExactPosition
position: 898
reference: G8XR08-1

SIP1F79BDAC31D355CF
type: Domain Extent Annotation
comment: PAZ
range: 20046675333625902tt283tt378

20046675333625902tt283
type: Position
type: ExactPosition
position: 283
reference: G8XR08-1

20046675333625902tt378
type: Position
type: ExactPosition
position: 378
reference: G8XR08-1

SIP4873B94A509DCF36
type: Domain Extent Annotation
comment: Piwi
range: 20046675333625902tt542tt883

20046675333625902tt542
type: Position
type: ExactPosition
position: 542
reference: G8XR08-1

20046675333625902tt883
type: Position
type: ExactPosition
position: 883
reference: G8XR08-1

SIPD7696242223AE8C7
type: Region Annotation
comment: Disordered
range: 20046675333625902tt1tt52

20046675333625902tt52
type: Position
type: ExactPosition
position: 52
reference: G8XR08-1

SIP1DACD92040743617
type: Compositional Bias Annotation
comment: Basic and acidic residues
range: 20046675333625902tt18tt36

20046675333625902tt18
type: Position
type: ExactPosition
position: 18
reference: G8XR08-1

20046675333625902tt36
type: Position
type: ExactPosition
position: 36
reference: G8XR08-1

G8XR08-1
type: Simple Sequence
modified: 2012-02-22
version: 1
mass: 100596
value: MLALNAGSQYPGRGRGRGRGDGGNRVHKHDGINRYHGGFRGGRGGGGGGFRDGDMRECRERESWAVSAAQANARTLARVPVPVETNCFPIDLSEGRFHNYIVSFEFLENATDMAGDMWKISLQNELLRTIRKNRTAEKRTRTSAEVEDLCVCTGQAILAPAKLSVEDGFSIECTRKEKVSRNNTEERHYRVRIRYDGEVSLKLPEHAQWVNKIIAFGLADTYSEHIGSDYVDMKSTVERGGDLVTMDAISLNALRIVKQSGSTTAMMDVLQLDVSTKASTKTKCSDEMRRLRQQNPQGFRRAVNEALVGISVTTVFGEPTFLKVKAIDFNILASSPTMFKTNPEETFVEYFKRKYDAIIDPTLPMLYCIFADRTKMSRRMPYPADSLLLNKLNEAQLSKLPILCSIYPNERMKRIKAALERVLASPLMITVLQQYGVRIQPQFVKVSGRVLPAPTIYVPSGPNMFNRINTAEYTGQAGFALGLKDLQHPSQPCEFKTLLMDEYFMHGNITHWLQKYNVALPSPRKTSFDSAAQRITEGPGTFAMVKLRTKEAGAYNNFKERFARSSIVSQMAVVDLTRNVPQMITQQVAAKIGQLCFVADVDEAGKSFACRPLLIVGAVVGTAMNTMLEKYKSINVRLYTITFVAFLANGKSWKPYCMHHQVKGEEHVLYEDSDAASSHMSSTTLTVRRQNANEVLNNRFPDFLKEVTAHFKLNGKGSKGTMVLYRGAMTDAEVGFTANMDLVMEQVLPNWDTATVVVHPRSHFRMAWDPTTVFPHETASAYAGLSNVPRGFSTTDCRIILADSDPYTPVDSFYLSAANCTLGHAANTYYLVQKRAASISLMDLQKLTYNMCYMYPNKPDALPLPLPIKCAYEYARKYGSLKSVKELPTRMRPTMHYL

http://purl.uniprot.org/uniprot/G8XR08#attribution-B13A37A11B8CCA5BB13AF656FB367D79
creator: UniProtKB
manual: true
evidence: ECO_0000315
source: http://purl.uniprot.org/citations/23217017

http://purl.uniprot.org/uniprot/G8XR08#attribution-8F7FBC23AD45D70C57FE7704DEC1F58E
creator: UniProtKB
manual: true
evidence: ECO_0000315
source: http://purl.uniprot.org/citations/21060810

http://purl.uniprot.org/uniprot/G8XR08#attribution-494B2F24F2806BAC751792B8B1DCC930
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/G8XR08#attribution-09A40CD9DF3A0077F104F85851E2A9BD
manual: true
evidence: ECO_0000255
source: PRU00142

http://purl.uniprot.org/uniprot/G8XR08#attribution-944114B703A38C702E34EB63500E8232
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/21060810

http://purl.uniprot.org/uniprot/G8XR08#attribution-3AACFB9AADBF1CA66F9F278BC6601CAE
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/23217017

http://purl.uniprot.org/uniprot/G8XR08#attribution-A8B7771C2DEC6BC0ACF83622B4BB78C4
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/21060810

http://purl.uniprot.org/uniprot/G8XR08#attribution-CEC7F7AA55F427BF912CFE46F7BEA0F8
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/23217017

http://purl.uniprot.org/uniprot/G8XR08#attribution-7D89CDB47B2791F35DA23D6DA345DB87
manual: true
evidence: ECO_0000305

http://purl.uniprot.org/uniprot/G8XR08#attribution-EB15F206CAD7ACC13AB2ABD338F1A278
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/23217017

http://purl.uniprot.org/uniprot/G8XR08#attribution-86CE65A3191FF2593E8AA60B4F420A8A
manual: true
evidence: ECO_0000312
source: ACI22628.1

Q25417
type: Protein
reviewed: true
created: 1997-11-01
modified: 2023-02-22
version: 91
mnemonic: ALDH2_LEITA
old mnemonic: DHAM_LEITA
citation: http://purl.uniprot.org/citations/7630384
recommended name: SIPEF0A120B8A16CAB4
alternative name: SIPF10A8874CEB15826
alternative name: SIP9EF3A640067D21A2
enzyme: http://purl.uniprot.org/enzyme/1.2.1.3
organism: http://purl.uniprot.org/taxonomy/5689
annotation: SIP164A1AACB42FFF21
annotation: SIP010E522BEB03E0EE
annotation: SIP60C11AC52FA20BE0
annotation: SIP56817B76F66C0E77
annotation: SIP875439D9707B85D0
annotation: SIPFB5BC1E658B419FF
annotation: PRO_0000007171
annotation: SIP79AC00F9F6A1C3D1
annotation: SIPB45790B38DFC28E4
annotation: SIP356BC9F2472BC3DF
annotation: SIP9E7D11C84CBC8420
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/496
classified with: http://purl.uniprot.org/keywords/520
classified with: http://purl.uniprot.org/keywords/560
classified with: http://purl.uniprot.org/keywords/694
classified with: http://purl.uniprot.org/keywords/809
classified with: GO_0005739
classified with: GO_0004029
classified with: GO_0043878
classified with: GO_0003723
classified with: GO_0006068
sequence: Q25417-1

Q25417-citation-7630384
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: PROTEIN SEQUENCE OF 10-31

UC
type: Strain

cd07091
type: Resource
database: CDD
comment: ALDH_F1-2_Ald2-like
signature sequence match: CDD cd07091 match 1

IPR016161
type: Resource
database: InterPro
comment: Ald_DH/histidinol_DH

IPR016163
type: Resource
database: InterPro
comment: Ald_DH_C

IPR016160
type: Resource
database: InterPro
comment: Ald_DH_CS_CYS

IPR029510
type: Resource
database: InterPro
comment: Ald_DH_CS_GLU

IPR016162
type: Resource
database: InterPro
comment: Ald_DH_N

IPR015590
type: Resource
database: InterPro
comment: Aldehyde_DH_dom

PTHR11699:SF211
type: Resource
database: PANTHER
comment: ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1
signature sequence match: PANTHER PTHR11699:SF211 match 1

PTHR11699
type: Resource
database: PANTHER
comment: ALDEHYDE DEHYDROGENASE-RELATED
signature sequence match: PANTHER PTHR11699 match 1

PF00171
type: Resource
database: Pfam
comment: Aldedh
signature sequence match: Pfam PF00171 match 1

SSF53720
type: Resource
database: SUPFAM
comment: ALDH-like
signature sequence match: SUPFAM SSF53720 match 1

PS00070
type: Resource
database: PROSITE
comment: ALDEHYDE_DEHYDR_CYS
signature sequence match: PROSITE PS00070 match 1

PS00687
type: Resource
database: PROSITE
comment: ALDEHYDE_DEHYDR_GLU
signature sequence match: PROSITE PS00687 match 1

SIPEF0A120B8A16CAB4
type: Structured Name
full name: Aldehyde dehydrogenase, mitochondrial
ec name: 1.2.1.3

SIPF10A8874CEB15826
type: Structured Name
full name: ALDH class 2

SIP9EF3A640067D21A2
type: Structured Name
full name: P51

ALDH2
type: Gene

SIP164A1AACB42FFF21
type: Function Annotation
comment: Could have an RNA-binding activity in addition of its catalytic role.

SIP875439D9707B85D0
type: Similarity Annotation
comment: Belongs to the aldehyde dehydrogenase family.

SIPFB5BC1E658B419FF
type: Transit Peptide Annotation
comment: Mitochondrion
range: 22854677203859246tt1tt9

22854677203859246tt1
type: Position
type: ExactPosition
position: 1
reference: Q25417-1

22854677203859246tt9
type: Position
type: ExactPosition
position: 9
reference: Q25417-1

PRO_0000007171
type: Chain Annotation
comment: Aldehyde dehydrogenase, mitochondrial
mass: 53225
range: 22854677203859246tt10tt498

22854677203859246tt10
type: Position
type: ExactPosition
position: 10
reference: Q25417-1

22854677203859246tt498
type: Position
type: ExactPosition
position: 498
reference: Q25417-1

SIP79AC00F9F6A1C3D1
type: Active Site Annotation
comment: Proton acceptor
range: 22854677203859246tt265tt265

22854677203859246tt265
type: Position
type: ExactPosition
position: 265
reference: Q25417-1

SIPB45790B38DFC28E4
type: Active Site Annotation
comment: Nucleophile
range: 22854677203859246tt299tt299

22854677203859246tt299
type: Position
type: ExactPosition
position: 299
reference: Q25417-1

22854677203859246tt242
type: Position
type: ExactPosition
position: 242
reference: Q25417-1

22854677203859246tt247
type: Position
type: ExactPosition
position: 247
reference: Q25417-1

SIP9E7D11C84CBC8420
type: Site Annotation
comment: Transition state stabilizer
range: 22854677203859246tt166tt166

22854677203859246tt166
type: Position
type: ExactPosition
position: 166
reference: Q25417-1

Q25417-1
type: Simple Sequence
modified: 1996-11-01
version: 1
precursor: true
mass: 54252
value: MLRATLARLEMAPKVTHIQEKLLINGKFVPAVSGKTFEVVNPADEKVIANVAEAEKADVDLAVKAARHAFESFRMTDCQWRRNLMLRLADILEKNSKEMAALESLDNGKPYEVALNVDVALSVECFRYCAGLADKVNGTVPPRSGNFLGIVKRQPIGVCGQIIPWNFPLLMAAFKLSPALAMGNTVVLKPAEQTPLTAVRLGEMVMEAGYPDGVLNILPGFGATAGSEIARHMDVDKIAFTGSTAVGHQVMQMAAETNLKKVSLELGGKSALIVCEDADLEEAAEVATTRVYFNTGQVCTASSRIYVHESVYDEFVSRLRKNAEARKVGPGNDTGNNMGPLVSKKQHERVLGYIEDGVKAGATVVTGGKKIGDKGYFVQPTIFSDVKEDMRICKEEIFGPVTCVMKYKDMDEVVKRANDSIYGLAAGICTRSMDTALRYSTYLNAGTVWVNTWNNFCPSMPFGGFKQSGIGRELGKEVVDMYTEPKAIHFASRSIVKP

http://purl.uniprot.org/uniprot/Q25417#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/Q25417#attribution-A2FE1347A4BB171E4CC9C3D6557F5E05
manual: true
evidence: ECO_0000250
source: P20000

http://purl.uniprot.org/uniprot/Q25417#attribution-54B6F2D3993B8882F4C1FC80B8FA535C
manual: true
evidence: ECO_0000255
source: PRU10007

http://purl.uniprot.org/uniprot/Q25417#attribution-4AAC2423DE28627E1A7E661E0118220B
manual: true
evidence: ECO_0000255
source: PRU10008

http://purl.uniprot.org/uniprot/Q25417#attribution-89542204EE2526D5CB210CF3FC4A1FE8
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/7630384

http://purl.uniprot.org/uniprot/Q25417#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

P07752
type: Protein
reviewed: true
created: 1988-08-01
modified: 2023-02-22
version: 125
mnemonic: ALF_TRYBB
old mnemonic: ALF_TRYBR
citation: http://purl.uniprot.org/citations/2998772
citation: http://purl.uniprot.org/citations/2349093
citation: http://purl.uniprot.org/citations/3386689
citation: http://purl.uniprot.org/citations/10891264
conflicting sequence: SIP4B7133B19D4DA514
recommended name: SIPC3971103E52AC195
enzyme: http://purl.uniprot.org/enzyme/4.1.2.13
organism: http://purl.uniprot.org/taxonomy/5702
annotation: SIP6F802C9F138FF9D7
annotation: SIPF93BB48D63EB3609
annotation: SIP51B183AEB8E41E9C
annotation: SIP1588970CC1DEB1CC
annotation: SIPCD8C4D76F4725FE9
annotation: PRO_0000216935
annotation: SIP406604CC59984719
annotation: SIP34B3DA63195371D1
annotation: SIP14B377888CAF8D53
annotation: SIPDB58F8234E55C2A1
annotation: SIP4696252624E3B59C
annotation: SIP737D26887EBDB9CC
annotation: SIP3248973CA861F8F9
annotation: SIP540BBBCB0270715E
annotation: SIP9564ECEC219DAA72
annotation: SIP880210CD3E291FF8
annotation: SIP5B72E80017885F5C
annotation: SIPDD98F37C3C90519E
annotation: SIP4824D2EF2C428CBB
annotation: SIP4E7607A9B3FE0C3B
annotation: SIP694CE3A9CD390BD9
annotation: SIPC9F3CD4AB805C435
annotation: SIPEB26C43FB1EEA53C
annotation: SIPC61FBE8CA2E08A0F
annotation: SIPB74FC28727798B37
annotation: SIP4502D8F4361432E1
annotation: SIPA86A5BF55C76D097
annotation: SIPF8794DC53AEDA79F
annotation: SIP632ED64CEA84BE5E
annotation: SIP277C14CDED231FAA
annotation: SIP7D6DE1FC8297E457
annotation: SIP0E033A1B4E0730E1
annotation: SIP78321B208F3158CA
annotation: SIP77C545AAAE865011
annotation: SIP04EBACC5AA118F3A
annotation: SIP3424FB7FDFE11DDC
annotation: SIP4A285B388F9D57DA
annotation: SIPBB2B20B0B46AC0C3
annotation: SIP43C957197D95CB09
annotation: SIP858E4779381D94D5
annotation: SIPA64D7D23B6FF0264
annotation: SIP23783BD0F91DE92E
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/324
classified with: http://purl.uniprot.org/keywords/327
classified with: http://purl.uniprot.org/keywords/456
classified with: http://purl.uniprot.org/keywords/576
classified with: http://purl.uniprot.org/keywords/704
classified with: GO_0020015
classified with: GO_0004332
classified with: GO_0006096
sequence: P07752-1

P07752-citation-2998772
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA]

P07752-citation-2349093
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

427
type: Strain

P07752-citation-3386689
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

P07752-citation-10891264
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 12-371

A24678
type: Resource
database: PIR
comment: ADUT

1F2J
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 1.90
chain sequence mapping: PDB 1F2J tt2tt371

PDB 1F2J tt2tt371
chain: A=2-371

cd00948
type: Resource
database: CDD
comment: FBP_aldolase_I_a
signature sequence match: CDD cd00948 match 1

http://purl.uniprot.org/gene3d/3.20.20.70
type: Resource
database: Gene3D
comment: Aldolase class I
signature sequence match: Gene3D 3.20.20.70 match 1

IPR029768
type: Resource
database: InterPro
comment: Aldolase_I_AS

IPR013785
type: Resource
database: InterPro
comment: Aldolase_TIM

IPR000741
type: Resource
database: InterPro
comment: FBA_I

PTHR11627
type: Resource
database: PANTHER
comment: FRUCTOSE-BISPHOSPHATE ALDOLASE
signature sequence match: PANTHER PTHR11627 match 1

PTHR11627:SF80
type: Resource
database: PANTHER
comment: FRUCTOSE-BISPHOSPHATE ALDOLASE
signature sequence match: PANTHER PTHR11627:SF80 match 1

PF00274
type: Resource
database: Pfam
comment: Glycolytic
signature sequence match: Pfam PF00274 match 1

SSF51569
type: Resource
database: SUPFAM
comment: Aldolase
signature sequence match: SUPFAM SSF51569 match 1

PS00158
type: Resource
database: PROSITE
comment: ALDOLASE_CLASS_I
signature sequence match: PROSITE PS00158 match 1

SIPC3971103E52AC195
type: Structured Name
full name: Fructose-bisphosphate aldolase, glycosomal
ec name: 4.1.2.13

ALD
type: Gene

SIP1588970CC1DEB1CC
type: Similarity Annotation
comment: Belongs to the class I fructose-bisphosphate aldolase family.

SIPCD8C4D76F4725FE9
type: Initiator Methionine Annotation
comment: Removed
range: 22571011844420142tt1tt1

22571011844420142tt1
type: Position
type: ExactPosition
position: 1
reference: P07752-1

PRO_0000216935
type: Chain Annotation
comment: Fructose-bisphosphate aldolase, glycosomal
mass: 41047
range: 22571011844420142tt2tt372

22571011844420142tt2
type: Position
type: ExactPosition
position: 2
reference: P07752-1

22571011844420142tt372
type: Position
type: ExactPosition
position: 372
reference: P07752-1

SIP406604CC59984719
type: Active Site Annotation
comment: Proton acceptor
range: 22571011844420142tt198tt198

22571011844420142tt198
type: Position
type: ExactPosition
position: 198
reference: P07752-1

SIP34B3DA63195371D1
type: Active Site Annotation
comment: Schiff-base intermediate with dihydroxyacetone-P
range: 22571011844420142tt240tt240

22571011844420142tt240
type: Position
type: ExactPosition
position: 240
reference: P07752-1

22571011844420142tt66
type: Position
type: ExactPosition
position: 66
reference: P07752-1

22571011844420142tt157
type: Position
type: ExactPosition
position: 157
reference: P07752-1

SIP4696252624E3B59C
type: Site Annotation
comment: Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate
range: 22571011844420142tt372tt372

SIP737D26887EBDB9CC
type: Sequence Conflict Annotation
conflicting sequence: SIP4B7133B19D4DA514
substitution: AT
range: 22571011844420142tt254tt255

22571011844420142tt254
type: Position
type: ExactPosition
position: 254
reference: P07752-1

22571011844420142tt255
type: Position
type: ExactPosition
position: 255
reference: P07752-1

22571011844420142tt9
type: Position
type: ExactPosition
position: 9
reference: P07752-1

22571011844420142tt11
type: Position
type: ExactPosition
position: 11
reference: P07752-1

22571011844420142tt13
type: Position
type: ExactPosition
position: 13
reference: P07752-1

22571011844420142tt15
type: Position
type: ExactPosition
position: 15
reference: P07752-1

22571011844420142tt23
type: Position
type: ExactPosition
position: 23
reference: P07752-1

22571011844420142tt33
type: Position
type: ExactPosition
position: 33
reference: P07752-1

22571011844420142tt39
type: Position
type: ExactPosition
position: 39
reference: P07752-1

22571011844420142tt43
type: Position
type: ExactPosition
position: 43
reference: P07752-1

22571011844420142tt47
type: Position
type: ExactPosition
position: 47
reference: P07752-1

22571011844420142tt55
type: Position
type: ExactPosition
position: 55
reference: P07752-1

22571011844420142tt56
type: Position
type: ExactPosition
position: 56
reference: P07752-1

22571011844420142tt58
type: Position
type: ExactPosition
position: 58
reference: P07752-1

22571011844420142tt63
type: Position
type: ExactPosition
position: 63
reference: P07752-1

22571011844420142tt74
type: Position
type: ExactPosition
position: 74
reference: P07752-1

22571011844420142tt79
type: Position
type: ExactPosition
position: 79
reference: P07752-1

22571011844420142tt81
type: Position
type: ExactPosition
position: 81
reference: P07752-1

22571011844420142tt83
type: Position
type: ExactPosition
position: 83
reference: P07752-1

22571011844420142tt88
type: Position
type: ExactPosition
position: 88
reference: P07752-1

22571011844420142tt90
type: Position
type: ExactPosition
position: 90
reference: P07752-1

22571011844420142tt94
type: Position
type: ExactPosition
position: 94
reference: P07752-1

22571011844420142tt100
type: Position
type: ExactPosition
position: 100
reference: P07752-1

22571011844420142tt102
type: Position
type: ExactPosition
position: 102
reference: P07752-1

22571011844420142tt103
type: Position
type: ExactPosition
position: 103
reference: P07752-1

22571011844420142tt109
type: Position
type: ExactPosition
position: 109
reference: P07752-1

22571011844420142tt113
type: Position
type: ExactPosition
position: 113
reference: P07752-1

22571011844420142tt117
type: Position
type: ExactPosition
position: 117
reference: P07752-1

22571011844420142tt122
type: Position
type: ExactPosition
position: 122
reference: P07752-1

22571011844420142tt124
type: Position
type: ExactPosition
position: 124
reference: P07752-1

22571011844420142tt126
type: Position
type: ExactPosition
position: 126
reference: P07752-1

22571011844420142tt129
type: Position
type: ExactPosition
position: 129
reference: P07752-1

22571011844420142tt133
type: Position
type: ExactPosition
position: 133
reference: P07752-1

22571011844420142tt135
type: Position
type: ExactPosition
position: 135
reference: P07752-1

22571011844420142tt141
type: Position
type: ExactPosition
position: 141
reference: P07752-1

22571011844420142tt150
type: Position
type: ExactPosition
position: 150
reference: P07752-1

22571011844420142tt155
type: Position
type: ExactPosition
position: 155
reference: P07752-1

22571011844420142tt162
type: Position
type: ExactPosition
position: 162
reference: P07752-1

22571011844420142tt171
type: Position
type: ExactPosition
position: 171
reference: P07752-1

22571011844420142tt190
type: Position
type: ExactPosition
position: 190
reference: P07752-1

22571011844420142tt194
type: Position
type: ExactPosition
position: 194
reference: P07752-1

22571011844420142tt201
type: Position
type: ExactPosition
position: 201
reference: P07752-1

22571011844420142tt209
type: Position
type: ExactPosition
position: 209
reference: P07752-1

22571011844420142tt230
type: Position
type: ExactPosition
position: 230
reference: P07752-1

22571011844420142tt234
type: Position
type: ExactPosition
position: 234
reference: P07752-1

22571011844420142tt236
type: Position
type: ExactPosition
position: 236
reference: P07752-1

22571011844420142tt256
type: Position
type: ExactPosition
position: 256
reference: P07752-1

22571011844420142tt270
type: Position
type: ExactPosition
position: 270
reference: P07752-1

22571011844420142tt277
type: Position
type: ExactPosition
position: 277
reference: P07752-1

22571011844420142tt280
type: Position
type: ExactPosition
position: 280
reference: P07752-1

22571011844420142tt287
type: Position
type: ExactPosition
position: 287
reference: P07752-1

22571011844420142tt297
type: Position
type: ExactPosition
position: 297
reference: P07752-1

22571011844420142tt306
type: Position
type: ExactPosition
position: 306
reference: P07752-1

22571011844420142tt313
type: Position
type: ExactPosition
position: 313
reference: P07752-1

22571011844420142tt314
type: Position
type: ExactPosition
position: 314
reference: P07752-1

22571011844420142tt324
type: Position
type: ExactPosition
position: 324
reference: P07752-1

22571011844420142tt328
type: Position
type: ExactPosition
position: 328
reference: P07752-1

22571011844420142tt330
type: Position
type: ExactPosition
position: 330
reference: P07752-1

22571011844420142tt331
type: Position
type: ExactPosition
position: 331
reference: P07752-1

22571011844420142tt349
type: Position
type: ExactPosition
position: 349
reference: P07752-1

22571011844420142tt355
type: Position
type: ExactPosition
position: 355
reference: P07752-1

22571011844420142tt357
type: Position
type: ExactPosition
position: 357
reference: P07752-1

substrate

P07752-1
type: Simple Sequence
modified: 2007-01-23
version: 2
mass: 41178
value: MSKRVEVLLTQLPAYNRLKTPYEAELIETAKKMTAPGKGLLAADESTGSCSKRFAGIGLSNTAEHRRQYRALMLECEGFEQYISGVILHDETVYQKAKTGETFPQYLRRRGVVPGIKTDCGLEPLVEGAKGEQMTAGLDGYIKRAKKYYAMGCRFCKWRNVYKIQNGTVSEAVVRFNAETLARYAILSQLCGLVPIVEPEVMIDGTHDIETCQRVSQHVWSEVVSALHRHGVVWEGCLLKPNMVVPGAESGLKGHAEQVAEYTVKTLARVIPPALPGVTFLSGGLSEVMASEYLNAMNNCPLPRPWKLTFSYARALQSSAIKRWGGKESGVEAGRRAFMHRAKMNSLAQLGKYNRADDDKDSQSLYVAGNTY

http://purl.uniprot.org/uniprot/P07752#attribution-979C012C4443F235B2E2E4A910B2FBC6
creator: GeneDB
manual: true
evidence: ECO_0000314
source: http://purl.uniprot.org/citations/24792668

http://purl.uniprot.org/uniprot/P07752#attribution-E1CB9036D38512F512140DE9217FCEC2
creator: GeneDB
manual: true
evidence: ECO_0000314
source: http://purl.uniprot.org/citations/32329788

http://purl.uniprot.org/uniprot/P07752#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/P07752#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

Q582G4
type: Protein
reviewed: true
created: 2009-05-05
modified: 2023-02-22
version: 77
mnemonic: ANM7_TRYB2
old mnemonic: ANM7_TRYBB
citation: http://purl.uniprot.org/citations/16020726
citation: http://purl.uniprot.org/citations/19254949
recommended name: SIP9048CADFDE4389F4
enzyme: http://purl.uniprot.org/enzyme/2.1.1.-
organism: http://purl.uniprot.org/taxonomy/185431
annotation: SIPE22A6030964DB1E2
annotation: SIPECBCA67125DE1C27
annotation: SIP337115ED95EE1E0A
annotation: SIP690626B0441CEDB8
annotation: SIP5374EA4FA7E4BC00
annotation: SIP3E5E8E4641C46EE0
annotation: PRO_0000373923
annotation: SIPD8CE13C0F83EFA8F
annotation: SIPBD19D087EE719F48
annotation: SIP8F64E92C27A66EE4
annotation: SIPF8AE0F54590B89CF
annotation: SIPCDE67C53A2A82D46
annotation: SIPAADE286614059A13
annotation: SIP1C307E26360E4272
annotation: SIP50379D00AF987B51
annotation: SIP01B45C8F05CF1897
annotation: SIP19B835D4EB7D3AF7
annotation: SIP873FE6A958A57A42
annotation: SIP887DB23C575BECE2
annotation: SIP6BBD7AFDF27F9FAE
annotation: SIPC03D684F12165906
annotation: SIPB997CB6E1A035513
annotation: SIP9274D3769B34B691
annotation: SIPC0F5C812E6921504
annotation: SIP33F6535C64655080
annotation: SIPB7517402A992AEDA
annotation: SIP4EA94BAE212E2E7E
annotation: SIPA1E87F6430069255
annotation: SIP5C7AF3645F89C99F
annotation: SIPAF41223366E612FC
annotation: SIP5FEB6B6608EF3CB1
annotation: SIPC0869581FB79A8CF
annotation: SIP94284982226A2E62
annotation: SIP024A4EDB55958A08
annotation: SIP0F68469FAE48624B
annotation: SIPE4768EE70F06CAA6
annotation: SIP9E4D7E2F27D2792D
annotation: SIP80C2BC025C0F7CDE
annotation: SIP4BC1C861D7A70873
annotation: SIPA166759430BF6265
annotation: SIP963EE7255E06848B
annotation: SIPCB6E12852DC75DBD
annotation: SIP6EF2EB9BD20A57BA
annotation: SIP201F6AC1569815CF
annotation: SIP643657FD2C8E3046
annotation: SIPA6947E5AC06514B9
annotation: SIP02C5764141E1BF8B
annotation: SIPF2050B096C627B4A
annotation: SIP6C579B065F782557
interaction: http://purl.uniprot.org/intact/16101095-16101095
interaction: http://purl.uniprot.org/intact/302023-16101095
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/489
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/949
classified with: GO_0005737
classified with: GO_0032991
classified with: GO_0016273
classified with: GO_0008469
classified with: GO_0042802
classified with: GO_0016274
classified with: GO_0035241
classified with: GO_0034969
classified with: GO_0018216
classified with: GO_0035246
sequence: Q582G4-1

Q582G4-citation-16020726
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

927/4 GUTat10.1
type: Strain

Q582G4-citation-19254949
type: Citation Statement
scope: FUNCTION
scope: SUBUNIT
scope: SUBCELLULAR LOCATION
scope: DEVELOPMENTAL STAGE

4M36
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.04
chain sequence mapping: PDB 4M36 tt36tt378

PDB 4M36 tt36tt378
chain: A=36-378

4M37
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 1.70
chain sequence mapping: PDB 4M37 tt36tt378

PDB 4M37 tt36tt378
chain: A=36-378

4M38
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.20
chain sequence mapping: PDB 4M38 tt36tt378

PDB 4M38 tt36tt378
chain: A/B=36-378

Q582G4
type: Resource
database: IntAct
comment: 2

KOG1501
type: Resource
database: eggNOG
comment: Eukaryota

http://purl.uniprot.org/brenda/2.1.1.321
type: Resource
database: BRENDA
comment: 6520

cd02440
type: Resource
database: CDD
comment: AdoMet_MTases
signature sequence match: CDD cd02440 match 1

http://purl.uniprot.org/gene3d/2.70.160.11
type: Resource
database: Gene3D
comment: Hnrnp arginine n-methyltransferase1
signature sequence match: Gene3D 2.70.160.11 match 1

http://purl.uniprot.org/gene3d/3.40.50.150
type: Resource
database: Gene3D
comment: Vaccinia Virus protein VP39
signature sequence match: Gene3D 3.40.50.150 match 1

IPR025799
type: Resource
database: InterPro
comment: Arg_MeTrfase

IPR029063
type: Resource
database: InterPro
comment: SAM-dependent_MTases_sf

PTHR11006
type: Resource
database: PANTHER
comment: PROTEIN ARGININE N-METHYLTRANSFERASE
signature sequence match: PANTHER PTHR11006 match 1

PTHR11006:SF4
type: Resource
database: PANTHER
comment: PROTEIN ARGININE N-METHYLTRANSFERASE 7
signature sequence match: PANTHER PTHR11006:SF4 match 1

PF06325
type: Resource
database: Pfam
comment: PrmA
signature sequence match: Pfam PF06325 match 1

SSF53335
type: Resource
database: SUPFAM
comment: S-adenosyl-L-methionine-dependent methyltransferases
signature sequence match: SUPFAM SSF53335 match 1

PS51678
type: Resource
database: PROSITE
comment: SAM_MT_PRMT
signature sequence match: PROSITE PS51678 match 1

SIP9048CADFDE4389F4
type: Structured Name
full name: Protein arginine N-methyltransferase 7
short name: TbPRMT7
ec name: 2.1.1.-

PRMT7
type: Gene
orf name: Tb927.7.5490

SIPE22A6030964DB1E2
type: Function Annotation
comment: Arginine methyltransferase that specifically catalyzes the formation of omega-N monomethylarginine (MMA). Has activity toward multiple substrates in vitro. Able to mediate the arginine methylation of histones and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.

SIPECBCA67125DE1C27
type: Subunit Annotation
comment: Present in large multiprotein complexes.

SIP690626B0441CEDB8
type: Developmental Stage Annotation
comment: Expressed during both bloodstream (BF) and procyclic insect (PF) life cycle stages.

SIP5374EA4FA7E4BC00
type: Similarity Annotation
comment: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.

SIP3E5E8E4641C46EE0
type: Caution Annotation
comment: Compared to PRMT7 orthologs in other metazoans, it is shorter and lacks the C-terminal part.

PRO_0000373923
type: Chain Annotation
comment: Protein arginine N-methyltransferase 7
mass: 44026
range: 22857988591531054tt1tt390

22857988591531054tt1
type: Position
type: ExactPosition
position: 1
reference: Q582G4-1

22857988591531054tt390
type: Position
type: ExactPosition
position: 390
reference: Q582G4-1

SIPD8CE13C0F83EFA8F
type: Domain Extent Annotation
comment: SAM-dependent MTase PRMT-type
range: 22857988591531054tt55tt372

22857988591531054tt55
type: Position
type: ExactPosition
position: 55
reference: Q582G4-1

22857988591531054tt372
type: Position
type: ExactPosition
position: 372
reference: Q582G4-1

SIPBD19D087EE719F48
type: Region Annotation
comment: Disordered
range: 22857988591531054tt1tt20

22857988591531054tt20
type: Position
type: ExactPosition
position: 20
reference: Q582G4-1

22857988591531054tt172
type: Position
type: ExactPosition
position: 172
reference: Q582G4-1

22857988591531054tt181
type: Position
type: ExactPosition
position: 181
reference: Q582G4-1

22857988591531054tt43
type: Position
type: ExactPosition
position: 43
reference: Q582G4-1

22857988591531054tt46
type: Position
type: ExactPosition
position: 46
reference: Q582G4-1

22857988591531054tt58
type: Position
type: ExactPosition
position: 58
reference: Q582G4-1

22857988591531054tt62
type: Position
type: ExactPosition
position: 62
reference: Q582G4-1

22857988591531054tt70
type: Position
type: ExactPosition
position: 70
reference: Q582G4-1

22857988591531054tt72
type: Position
type: ExactPosition
position: 72
reference: Q582G4-1

22857988591531054tt76
type: Position
type: ExactPosition
position: 76
reference: Q582G4-1

22857988591531054tt79
type: Position
type: ExactPosition
position: 79
reference: Q582G4-1

22857988591531054tt90
type: Position
type: ExactPosition
position: 90
reference: Q582G4-1

22857988591531054tt98
type: Position
type: ExactPosition
position: 98
reference: Q582G4-1

22857988591531054tt102
type: Position
type: ExactPosition
position: 102
reference: Q582G4-1

22857988591531054tt108
type: Position
type: ExactPosition
position: 108
reference: Q582G4-1

22857988591531054tt115
type: Position
type: ExactPosition
position: 115
reference: Q582G4-1

22857988591531054tt119
type: Position
type: ExactPosition
position: 119
reference: Q582G4-1

22857988591531054tt126
type: Position
type: ExactPosition
position: 126
reference: Q582G4-1

22857988591531054tt128
type: Position
type: ExactPosition
position: 128
reference: Q582G4-1

22857988591531054tt140
type: Position
type: ExactPosition
position: 140
reference: Q582G4-1

22857988591531054tt144
type: Position
type: ExactPosition
position: 144
reference: Q582G4-1

22857988591531054tt146
type: Position
type: ExactPosition
position: 146
reference: Q582G4-1

22857988591531054tt147
type: Position
type: ExactPosition
position: 147
reference: Q582G4-1

22857988591531054tt152
type: Position
type: ExactPosition
position: 152
reference: Q582G4-1

22857988591531054tt154
type: Position
type: ExactPosition
position: 154
reference: Q582G4-1

22857988591531054tt156
type: Position
type: ExactPosition
position: 156
reference: Q582G4-1

22857988591531054tt159
type: Position
type: ExactPosition
position: 159
reference: Q582G4-1

22857988591531054tt161
type: Position
type: ExactPosition
position: 161
reference: Q582G4-1

22857988591531054tt162
type: Position
type: ExactPosition
position: 162
reference: Q582G4-1

22857988591531054tt164
type: Position
type: ExactPosition
position: 164
reference: Q582G4-1

22857988591531054tt167
type: Position
type: ExactPosition
position: 167
reference: Q582G4-1

22857988591531054tt171
type: Position
type: ExactPosition
position: 171
reference: Q582G4-1

22857988591531054tt183
type: Position
type: ExactPosition
position: 183
reference: Q582G4-1

22857988591531054tt193
type: Position
type: ExactPosition
position: 193
reference: Q582G4-1

22857988591531054tt200
type: Position
type: ExactPosition
position: 200
reference: Q582G4-1

22857988591531054tt203
type: Position
type: ExactPosition
position: 203
reference: Q582G4-1

22857988591531054tt205
type: Position
type: ExactPosition
position: 205
reference: Q582G4-1

22857988591531054tt214
type: Position
type: ExactPosition
position: 214
reference: Q582G4-1

22857988591531054tt216
type: Position
type: ExactPosition
position: 216
reference: Q582G4-1

22857988591531054tt219
type: Position
type: ExactPosition
position: 219
reference: Q582G4-1

22857988591531054tt220
type: Position
type: ExactPosition
position: 220
reference: Q582G4-1

22857988591531054tt222
type: Position
type: ExactPosition
position: 222
reference: Q582G4-1

22857988591531054tt233
type: Position
type: ExactPosition
position: 233
reference: Q582G4-1

22857988591531054tt238
type: Position
type: ExactPosition
position: 238
reference: Q582G4-1

22857988591531054tt247
type: Position
type: ExactPosition
position: 247
reference: Q582G4-1

22857988591531054tt250
type: Position
type: ExactPosition
position: 250
reference: Q582G4-1

22857988591531054tt254
type: Position
type: ExactPosition
position: 254
reference: Q582G4-1

22857988591531054tt256
type: Position
type: ExactPosition
position: 256
reference: Q582G4-1

22857988591531054tt266
type: Position
type: ExactPosition
position: 266
reference: Q582G4-1

22857988591531054tt272
type: Position
type: ExactPosition
position: 272
reference: Q582G4-1

22857988591531054tt273
type: Position
type: ExactPosition
position: 273
reference: Q582G4-1

22857988591531054tt275
type: Position
type: ExactPosition
position: 275
reference: Q582G4-1

22857988591531054tt278
type: Position
type: ExactPosition
position: 278
reference: Q582G4-1

22857988591531054tt280
type: Position
type: ExactPosition
position: 280
reference: Q582G4-1

22857988591531054tt283
type: Position
type: ExactPosition
position: 283
reference: Q582G4-1

22857988591531054tt290
type: Position
type: ExactPosition
position: 290
reference: Q582G4-1

22857988591531054tt295
type: Position
type: ExactPosition
position: 295
reference: Q582G4-1

22857988591531054tt297
type: Position
type: ExactPosition
position: 297
reference: Q582G4-1

22857988591531054tt299
type: Position
type: ExactPosition
position: 299
reference: Q582G4-1

22857988591531054tt308
type: Position
type: ExactPosition
position: 308
reference: Q582G4-1

22857988591531054tt311
type: Position
type: ExactPosition
position: 311
reference: Q582G4-1

22857988591531054tt314
type: Position
type: ExactPosition
position: 314
reference: Q582G4-1

22857988591531054tt317
type: Position
type: ExactPosition
position: 317
reference: Q582G4-1

22857988591531054tt319
type: Position
type: ExactPosition
position: 319
reference: Q582G4-1

22857988591531054tt320
type: Position
type: ExactPosition
position: 320
reference: Q582G4-1

22857988591531054tt322
type: Position
type: ExactPosition
position: 322
reference: Q582G4-1

22857988591531054tt324
type: Position
type: ExactPosition
position: 324
reference: Q582G4-1

22857988591531054tt329
type: Position
type: ExactPosition
position: 329
reference: Q582G4-1

22857988591531054tt333
type: Position
type: ExactPosition
position: 333
reference: Q582G4-1

22857988591531054tt336
type: Position
type: ExactPosition
position: 336
reference: Q582G4-1

22857988591531054tt342
type: Position
type: ExactPosition
position: 342
reference: Q582G4-1

22857988591531054tt344
type: Position
type: ExactPosition
position: 344
reference: Q582G4-1

22857988591531054tt348
type: Position
type: ExactPosition
position: 348
reference: Q582G4-1

22857988591531054tt350
type: Position
type: ExactPosition
position: 350
reference: Q582G4-1

22857988591531054tt355
type: Position
type: ExactPosition
position: 355
reference: Q582G4-1

22857988591531054tt362
type: Position
type: ExactPosition
position: 362
reference: Q582G4-1

22857988591531054tt369
type: Position
type: ExactPosition
position: 369
reference: Q582G4-1

22857988591531054tt374
type: Position
type: ExactPosition
position: 374
reference: Q582G4-1

http://purl.uniprot.org/intact/16101095-16101095
type: Interaction
type: Self Interaction
xeno: false
experiments: 2
participant: PRMT7

http://purl.uniprot.org/intact/302023-16101095
type: Interaction
type: Non Self Interaction
xeno: true
experiments: 4
participant: PRMT7
participant: H4C9

PRMT7
type: Participant

H4C9
type: Participant

Q582G4-1
type: Simple Sequence
modified: 2005-05-10
version: 1
mass: 44026
value: MPPKQHRHQKKDKNDNALQNTIGFVPPGATLASVSGYRPPDAFVNRIDRNIPVPARLRHTPVSLIEAVNDFHYAMMNDEERNNFYYEVLKKHVTPETGVLEIGAGSGLLSLMAAKLGAKWVVAVEGSEELAKLARENIRANNMEHQVKVLHMMSTELKSKHLPEPPDVLLSEIFGTMMLGESALDYVVDVRNRLLKPTTKIIPQFGTQYAVPIECDALHRISSVSGWRDLDLKHMMTLQDTVSIVFAKHYGIRMNSVNFRRLSDPIELFRVDFSSSNRNDIPRRKHFDVVAKESGTAHAMLFYWKVTDDEFVMSTDPEDTVNNFPRDMQWGQALQLLDASNGPLPTPVVFTEGKNYNFECNFSGDRVILHMQLCPESGNGEMTECEGKTT

http://purl.uniprot.org/uniprot/Q582G4#attribution-B7EDFBD72241325B685358CDDC592632
creator: UniProtKB
manual: true
evidence: ECO_0000314
source: http://purl.uniprot.org/citations/19254949

http://purl.uniprot.org/uniprot/Q582G4#attribution-E12B851F24C094365696F30C87A766F4
creator: GeneDB
manual: true
evidence: ECO_0000314
source: http://purl.uniprot.org/citations/19254949

http://purl.uniprot.org/uniprot/Q582G4#attribution-E969819F38215BFD0A97B028E711DE9A
creator: UniProtKB
manual: true
evidence: ECO_0000304
source: http://purl.uniprot.org/citations/19254949

http://purl.uniprot.org/uniprot/Q582G4#attribution-BAEEE5102A70ADBFEFD0ECF19585140E
creator: IntAct
manual: true
evidence: ECO_0000353
source: http://purl.uniprot.org/citations/24726341

http://purl.uniprot.org/uniprot/Q582G4#attribution-0805D343A25D9F44C91CBB2C5680EC43
creator: GeneDB
manual: true
evidence: ECO_0000266

http://purl.uniprot.org/uniprot/Q582G4#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/Q582G4#attribution-7FD74799EE588E427D6F0DA9BB587B28
manual: true
evidence: ECO_0000255
source: PRU01015

http://purl.uniprot.org/uniprot/Q582G4#attribution-63B7B37EE870795815C7218FBDFEA1E4
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/19254949

http://purl.uniprot.org/uniprot/Q582G4#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

http://purl.uniprot.org/uniprot/Q582G4#attribution-F926B10BF8A9C4F6D60F957D5C681920
manual: true
evidence: ECO_0000312
source: UP000008524

Q26710
type: Protein
reviewed: true
created: 1998-07-15
modified: 2023-05-03
version: 109
mnemonic: AOX_TRYBB
replaces: Q8WPA4
citation: http://purl.uniprot.org/citations/9010848
citation: SIP2465D0D0716A8E41
citation: http://purl.uniprot.org/citations/12113758
citation: http://purl.uniprot.org/citations/10225419
citation: http://purl.uniprot.org/citations/23487766
recommended name: SIP003E1629D7A3681C
enzyme: http://purl.uniprot.org/enzyme/1.-.-.-
organism: http://purl.uniprot.org/taxonomy/5702
annotation: SIP23739CE4BCB46B50
annotation: SIPC512C5BDA737B7E4
annotation: SIPCC8E3E99B5504929
annotation: SIP9A334137DE02335A
annotation: SIPE31CAEF89CB44921
annotation: SIP4675472C2D61B3B2
annotation: PRO_0000001730
annotation: SIP66EDC239CB054247
annotation: SIPD582A3CAAF94B551
annotation: SIPE013A3C0E0AC6CAA
annotation: SIP07C3A66C0F0C12E2
annotation: SIPD044A1C04935C2C6
annotation: SIP6FAC40FD56D8B2C1
annotation: SIP1DE04E6F8D761F19
annotation: SIPC384AD0FADEBDE2B
annotation: SIPA1608477C222AAE8
annotation: SIP415834E6D4AABD8E
annotation: SIP7C21061638AF85F9
annotation: SIP38C610AC3E810BAF
annotation: SIPB7BFAD35107557DD
annotation: SIP72E1A3511F0FEB17
annotation: SIP7B3C65481A2DF52B
annotation: SIPA04CB3C41EE0E34D
annotation: SIP3F32AA79B1E2C7C9
annotation: SIP92CFBC95AF35AA05
annotation: SIPF0EF57CE1C507AB8
annotation: SIP1EE8959D70FB95EB
annotation: SIP5CF1B93DF9C534F0
annotation: SIPD71B8E14A70E5AE5
annotation: SIPAD2B65D32C7A92D4
annotation: SIP03A69C22342580D9
annotation: SIPDDE03C57BEDA7C6D
annotation: SIP04809A95C0B3DF14
annotation: SIPE08C036F9E9B2D10
annotation: SIPA5C3186456B3EAB9
annotation: SIPC2BBBE222F29F06C
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/1015
classified with: http://purl.uniprot.org/keywords/408
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/999
classified with: http://purl.uniprot.org/keywords/560
classified with: http://purl.uniprot.org/keywords/679
classified with: http://purl.uniprot.org/keywords/809
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0005743
classified with: GO_0005739
classified with: GO_0070469
classified with: GO_0009916
classified with: GO_0008199
classified with: GO_0016491
sequence: Q26710-1

Q26710-citation-9010848
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA]

EATRO 110
type: Strain

SIP2465D0D0716A8E41
type: Submission Citation
author: Hill G.C.
author: Chaudhuri M.
author: Ott R.
date: 2004-03
submitted to: EMBL/GenBank/DDBJ

Q26710-citation-SIP2465D0D0716A8E41
type: Citation Statement
scope: SEQUENCE REVISION

Q26710-citation-12113758
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA]

ILTat 1.4
type: Strain

TC221
type: Strain

Q26710-citation-10225419
type: Citation Statement
scope: IRON-BINDING SITES

Q26710-citation-23487766
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) IN COMPLEX WITH IRON IONS

3VV9
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.85
chain sequence mapping: PDB 3VV9 tt1tt329

PDB 3VV9 tt1tt329
chain: A/B/C/D=1-329

3VVA
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.59
chain sequence mapping: PDB 3VVA tt1tt329

PDB 3VVA tt1tt329
chain: A/B/C/D=1-329

3W54
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.30
chain sequence mapping: PDB 3W54 tt1tt329

PDB 3W54 tt1tt329
chain: A/B/C/D=1-329

5GN7
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 3.20
chain sequence mapping: PDB 5GN7 tt1tt329

PDB 5GN7 tt1tt329
chain: A/B/C/D=1-329

5GN9
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 3.20
chain sequence mapping: PDB 5GN9 tt1tt329

PDB 5GN9 tt1tt329
chain: A/B/C/D=1-329

5ZDP
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.71
chain sequence mapping: PDB 5ZDP tt1tt329

PDB 5ZDP tt1tt329
chain: A/B/C/D=1-329

5ZDQ
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.30
chain sequence mapping: PDB 5ZDQ tt1tt329

PDB 5ZDQ tt1tt329
chain: A/B/C/D=1-329

5ZDR
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.59
chain sequence mapping: PDB 5ZDR tt1tt329

PDB 5ZDR tt1tt329
chain: A/B/C/D=1-329

http://purl.uniprot.org/brenda/1.10.3.11
type: Resource
database: BRENDA
comment: 6519

cd01053
type: Resource
database: CDD
comment: AOX
signature sequence match: CDD cd01053 match 1

http://purl.uniprot.org/gene3d/1.20.1260.140
type: Resource
database: Gene3D
comment: Alternative oxidase
signature sequence match: Gene3D 1.20.1260.140 match 1

IPR002680
type: Resource
database: InterPro
comment: AOX

IPR038659
type: Resource
database: InterPro
comment: AOX_sf

PTHR31803
type: Resource
database: PANTHER
comment: ALTERNATIVE OXIDASE
signature sequence match: PANTHER PTHR31803 match 1

PTHR31803:SF3
type: Resource
database: PANTHER
comment: ALTERNATIVE OXIDASE
signature sequence match: PANTHER PTHR31803:SF3 match 1

PF01786
type: Resource
database: Pfam
comment: AOX
signature sequence match: Pfam PF01786 match 1

PIRSF005229
type: Resource
database: PIRSF
comment: AOX
signature sequence match: PIRSF PIRSF005229 match 1

SIP003E1629D7A3681C
type: Structured Name
full name: Alternative oxidase, mitochondrial
ec name: 1.-.-.-

AOX
type: Gene

SIP23739CE4BCB46B50
type: Function Annotation
comment: Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.

SIPC512C5BDA737B7E4
type: Cofactor Annotation
comment: Binds 2 iron ions per subunit.
cofactor: CHEBI_24875

SIPCC8E3E99B5504929
type: Subunit Annotation
comment: Homodimer; disulfide-linked.

SIP9A334137DE02335A
type: Subcellular Location Annotation
comment: Mitochondrial, possibly in the inner surface of the inner mitochondrial membrane.
located in: SIP68CF60B1D7EFC658

SIPE31CAEF89CB44921
type: Similarity Annotation
comment: Belongs to the alternative oxidase family.

SIP4675472C2D61B3B2
type: Transit Peptide Annotation
comment: Mitochondrion
range: 22854681549156398tt1ne

22854681549156398tt1
type: Position
type: ExactPosition
position: 1
reference: Q26710-1

PRO_0000001730
type: Chain Annotation
comment: Alternative oxidase, mitochondrial
mass: 37590
range: 22854681549156398nbtt329

22854681549156398tt329
type: Position
type: ExactPosition
position: 329
reference: Q26710-1

SIP66EDC239CB054247
type: Transmembrane Annotation
comment: Helical
range: 22854681549156398tt115tt135

22854681549156398tt115
type: Position
type: ExactPosition
position: 115
reference: Q26710-1

22854681549156398tt135
type: Position
type: ExactPosition
position: 135
reference: Q26710-1

SIPD582A3CAAF94B551
type: Transmembrane Annotation
comment: Helical
range: 22854681549156398tt181tt201

22854681549156398tt181
type: Position
type: ExactPosition
position: 181
reference: Q26710-1

22854681549156398tt201
type: Position
type: ExactPosition
position: 201
reference: Q26710-1

SIPE013A3C0E0AC6CAA
type: Region Annotation
comment: Disordered
range: 22854681549156398tt300tt329

22854681549156398tt300
type: Position
type: ExactPosition
position: 300
reference: Q26710-1

22854681549156398tt123
type: Position
type: ExactPosition
position: 123
reference: Q26710-1

22854681549156398tt162
type: Position
type: ExactPosition
position: 162
reference: Q26710-1

22854681549156398tt165
type: Position
type: ExactPosition
position: 165
reference: Q26710-1

22854681549156398tt213
type: Position
type: ExactPosition
position: 213
reference: Q26710-1

22854681549156398tt266
type: Position
type: ExactPosition
position: 266
reference: Q26710-1

22854681549156398tt269
type: Position
type: ExactPosition
position: 269
reference: Q26710-1

SIP38C610AC3E810BAF
type: Disulfide Bond Annotation
comment: Interchain
range: 22854681549156398tt95tt95

22854681549156398tt95
type: Position
type: ExactPosition
position: 95
reference: Q26710-1

22854681549156398tt35
type: Position
type: ExactPosition
position: 35
reference: Q26710-1

22854681549156398tt38
type: Position
type: ExactPosition
position: 38
reference: Q26710-1

22854681549156398tt44
type: Position
type: ExactPosition
position: 44
reference: Q26710-1

22854681549156398tt49
type: Position
type: ExactPosition
position: 49
reference: Q26710-1

22854681549156398tt54
type: Position
type: ExactPosition
position: 54
reference: Q26710-1

22854681549156398tt56
type: Position
type: ExactPosition
position: 56
reference: Q26710-1

22854681549156398tt67
type: Position
type: ExactPosition
position: 67
reference: Q26710-1

22854681549156398tt70
type: Position
type: ExactPosition
position: 70
reference: Q26710-1

22854681549156398tt83
type: Position
type: ExactPosition
position: 83
reference: Q26710-1

22854681549156398tt102
type: Position
type: ExactPosition
position: 102
reference: Q26710-1

22854681549156398tt106
type: Position
type: ExactPosition
position: 106
reference: Q26710-1

22854681549156398tt108
type: Position
type: ExactPosition
position: 108
reference: Q26710-1

22854681549156398tt112
type: Position
type: ExactPosition
position: 112
reference: Q26710-1

22854681549156398tt126
type: Position
type: ExactPosition
position: 126
reference: Q26710-1

22854681549156398tt129
type: Position
type: ExactPosition
position: 129
reference: Q26710-1

22854681549156398tt144
type: Position
type: ExactPosition
position: 144
reference: Q26710-1

22854681549156398tt151
type: Position
type: ExactPosition
position: 151
reference: Q26710-1

22854681549156398tt172
type: Position
type: ExactPosition
position: 172
reference: Q26710-1

22854681549156398tt177
type: Position
type: ExactPosition
position: 177
reference: Q26710-1

22854681549156398tt200
type: Position
type: ExactPosition
position: 200
reference: Q26710-1

22854681549156398tt202
type: Position
type: ExactPosition
position: 202
reference: Q26710-1

22854681549156398tt228
type: Position
type: ExactPosition
position: 228
reference: Q26710-1

22854681549156398tt230
type: Position
type: ExactPosition
position: 230
reference: Q26710-1

22854681549156398tt232
type: Position
type: ExactPosition
position: 232
reference: Q26710-1

22854681549156398tt241
type: Position
type: ExactPosition
position: 241
reference: Q26710-1

22854681549156398tt246
type: Position
type: ExactPosition
position: 246
reference: Q26710-1

22854681549156398tt255
type: Position
type: ExactPosition
position: 255
reference: Q26710-1

22854681549156398tt281
type: Position
type: ExactPosition
position: 281
reference: Q26710-1

22854681549156398tt285
type: Position
type: ExactPosition
position: 285
reference: Q26710-1

22854681549156398tt287
type: Position
type: ExactPosition
position: 287
reference: Q26710-1

22854681549156398tt290
type: Position
type: ExactPosition
position: 290
reference: Q26710-1

22854681549156398tt292
type: Position
type: ExactPosition
position: 292
reference: Q26710-1

22854681549156398tt294
type: Position
type: ExactPosition
position: 294
reference: Q26710-1

22854681549156398tt296
type: Position
type: ExactPosition
position: 296
reference: Q26710-1

1
subclass of: CHEBI_24875

2
subclass of: CHEBI_24875

Q26710-1
type: Simple Sequence
modified: 2004-08-16
version: 2
precursor: true
mass: 37590
value: MFRNHASRITAAAAPWVLRTACRQKSDAKTPVWGHTQLNRLSFLETVPVVPLRVSDESSEDRPTWSLPDIENVAITHKKPNGLVDTLAYRSVRTCRWLFDTFSLYRFGSITESKVISRCLFLETVAGVPGMVGGMLRHLSSLRYMTRDKGWINTLLVEAENERMHLMTFIELRQPGLPLRVSIIITQAIMYLFLLVAYVISPRFVHRFVGYLEEEAVITYTGVMRAIDEGRLRPTKNDVPEVARVYWNLSKNATFRDLINVIRADEAEHRVVNHTFADMHEKRLQNSVNPFVVLKKNPEEMYSNQPSGKTRTDFGSEGAKTASNVNKHV

http://purl.uniprot.org/uniprot/Q26710#attribution-E1253905149D70048D760A501409A164
creator: GeneDB
manual: true
evidence: ECO_0000314
source: http://purl.uniprot.org/citations/18021773

http://purl.uniprot.org/uniprot/Q26710#attribution-22614BCD959803AF6D2D9CAAC8CFAF14
creator: GeneDB
manual: true
evidence: ECO_0000314
source: http://purl.uniprot.org/citations/9763289

http://purl.uniprot.org/uniprot/Q26710#attribution-D4FF45B7CEFA28522C0067EF70DCFD8A
creator: GeneDB
manual: true
evidence: ECO_0000314
source: http://purl.uniprot.org/citations/12633849

http://purl.uniprot.org/uniprot/Q26710#attribution-C645177D16A4CB6041D1865DAB9F4736
creator: GeneDB
manual: true
evidence: ECO_0000314
source: http://purl.uniprot.org/citations/20056101

http://purl.uniprot.org/uniprot/Q26710#attribution-BE7E01052D4E203667949A9F424FDE32
creator: GeneDB
manual: true
evidence: ECO_0000304
source: http://purl.uniprot.org/citations/12188215

http://purl.uniprot.org/uniprot/Q26710#attribution-DC036A124EC8E88DF072B29F6D9BB9FE
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/Q26710#attribution-A699986A85EBA8F4FA5FE2805F819F1B
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/23487766

http://purl.uniprot.org/uniprot/Q26710#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

http://purl.uniprot.org/uniprot/Q26710#attribution-AAA6F430AA9E98B58C1160E3F6DC612A
manual: true
evidence: ECO_0007744
source: 3W54

Q05885
type: Protein
reviewed: true
created: 1994-02-01
modified: 2023-02-22
version: 72
mnemonic: ARD1_LEIDO
old mnemonic: ARD1A_LEIDO
old mnemonic: ARD1H_LEIDO
old mnemonic: ARDH_LEIDO
citation: http://purl.uniprot.org/citations/8378337
recommended name: SIPF7A4E7641EA28310
enzyme: http://purl.uniprot.org/enzyme/2.3.1.-
organism: http://purl.uniprot.org/taxonomy/5661
annotation: SIP558B8B902C334FB3
annotation: SIPD578FED2378AE4DE
annotation: PRO_0000074531
annotation: SIP3216D787C64F60D5
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/12
classified with: GO_0016747
sequence: MTTYRRMTLCDTLQFNFVNLDQLTETYNTSFYGEYVTHWPEYQRMCVHPTTNIPMAYTLGKAEGQGEDYHGHVSAVSVAPTFRRVALGETLMAELAQMSELVHNAYFVDLFVRKSNQVAQDMYHRLGYIVYRTVLNYYHGDGPKGPFKSDEDALDMRLALRRDKERRKSSVIPLDRPIKPEELEWV

Q05885-citation-8378337
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE

Ld4
type: Strain

IPR016181
type: Resource
database: InterPro
comment: Acyl_CoA_acyltransferase

IPR013653
type: Resource
database: InterPro
comment: FR47

IPR000182
type: Resource
database: InterPro
comment: GNAT_dom

PTHR45910
type: Resource
database: PANTHER
comment: N-ALPHA-ACETYLTRANSFERASE 20
signature sequence match: PANTHER PTHR45910 match 1

PTHR45910:SF1
type: Resource
database: PANTHER
comment: N-ALPHA-ACETYLTRANSFERASE 20
signature sequence match: PANTHER PTHR45910:SF1 match 1

PF08445
type: Resource
database: Pfam
comment: FR47
signature sequence match: Pfam PF08445 match 1

SSF55729
type: Resource
database: SUPFAM
comment: Acyl-CoA N-acyltransferases (Nat)
signature sequence match: SUPFAM SSF55729 match 1

PS51186
type: Resource
database: PROSITE
comment: GNAT
signature sequence match: PROSITE PS51186 match 1

SIPF7A4E7641EA28310
type: Structured Name
full name: N-terminal acetyltransferase complex ARD1 subunit homolog
ec name: 2.3.1.-

ARD1
type: Gene

SIP558B8B902C334FB3
type: Function Annotation
comment: Seems to be involved in N-acetylation.

SIPD578FED2378AE4DE
type: Similarity Annotation
comment: Belongs to the acetyltransferase family. ARD1 subfamily.

PRO_0000074531
type: Chain Annotation
comment: N-terminal acetyltransferase complex ARD1 subunit homolog
mass: 21684
range: 22852478248170798tt1tt186

22852478248170798tt1
type: Position
type: ExactPosition
position: 1
reference: MTTYRRMTLCDTLQFNFVNLDQLTETYNTSFYGEYVTHWPEYQRMCVHPTTNIPMAYTLGKAEGQGEDYHGHVSAVSVAPTFRRVALGETLMAELAQMSELVHNAYFVDLFVRKSNQVAQDMYHRLGYIVYRTVLNYYHGDGPKGPFKSDEDALDMRLALRRDKERRKSSVIPLDRPIKPEELEWV

22852478248170798tt186
type: Position
type: ExactPosition
position: 186
reference: MTTYRRMTLCDTLQFNFVNLDQLTETYNTSFYGEYVTHWPEYQRMCVHPTTNIPMAYTLGKAEGQGEDYHGHVSAVSVAPTFRRVALGETLMAELAQMSELVHNAYFVDLFVRKSNQVAQDMYHRLGYIVYRTVLNYYHGDGPKGPFKSDEDALDMRLALRRDKERRKSSVIPLDRPIKPEELEWV

SIP3216D787C64F60D5
type: Domain Extent Annotation
comment: N-acetyltransferase
range: 22852478248170798tt2tt161

22852478248170798tt2
type: Position
type: ExactPosition
position: 2
reference: MTTYRRMTLCDTLQFNFVNLDQLTETYNTSFYGEYVTHWPEYQRMCVHPTTNIPMAYTLGKAEGQGEDYHGHVSAVSVAPTFRRVALGETLMAELAQMSELVHNAYFVDLFVRKSNQVAQDMYHRLGYIVYRTVLNYYHGDGPKGPFKSDEDALDMRLALRRDKERRKSSVIPLDRPIKPEELEWV

22852478248170798tt161
type: Position
type: ExactPosition
position: 161
reference: MTTYRRMTLCDTLQFNFVNLDQLTETYNTSFYGEYVTHWPEYQRMCVHPTTNIPMAYTLGKAEGQGEDYHGHVSAVSVAPTFRRVALGETLMAELAQMSELVHNAYFVDLFVRKSNQVAQDMYHRLGYIVYRTVLNYYHGDGPKGPFKSDEDALDMRLALRRDKERRKSSVIPLDRPIKPEELEWV

MTTYRRMTLCDTLQFNFVNLDQLTETYNTSFYGEYVTHWPEYQRMCVHPTTNIPMAYTLGKAEGQGEDYHGHVSAVSVAPTFRRVALGETLMAELAQMSELVHNAYFVDLFVRKSNQVAQDMYHRLGYIVYRTVLNYYHGDGPKGPFKSDEDALDMRLALRRDKERRKSSVIPLDRPIKPEELEWV
type: Simple Sequence
modified: 1994-02-01
version: 1
mass: 21684

http://purl.uniprot.org/uniprot/Q05885#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/Q05885#attribution-6AA02B9283E1430DDD499F56818BAD11
manual: true
evidence: ECO_0000255
source: PRU00532

http://purl.uniprot.org/uniprot/Q05885#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

Q04732
type: Protein
reviewed: true
created: 1993-10-01
modified: 2023-02-22
version: 72
mnemonic: ARP_EUGGR
old mnemonic: CBP_EUGGR
citation: http://purl.uniprot.org/citations/1282888
recommended name: SIPDB4D59E398EEA89B
organism: http://purl.uniprot.org/taxonomy/3039
annotation: SIPEC0CD2317821AEBA
annotation: SIP3BF7F6E466CEC4E1
annotation: SIPBCF586A40FC69934
annotation: PRO_0000020757
annotation: SIP01D22668BDA3DBBB
annotation: SIPD719BEF7E2D73816
annotation: SIP01FFDACC5948105E
annotation: SIPE3093A8E7AE23C4D
annotation: SIP49A0FC6CBEB4E686
annotation: SIP22597D9D0020554D
annotation: SIP1A68C4EF3BF5EB90
annotation: SIP02E61BB6CF35052C
annotation: SIPB2BD8C6136AFC0FF
annotation: SIPCAD4D53CDAA9F15D
annotation: SIPB06FBAEE32ECFE50
annotation: SIP82CBE6613C3EDB4C
annotation: SIP734915E78D7096D2
annotation: SIP2043E7A7C40D3B4C
annotation: SIPF04D16A2A9934863
annotation: SIP7C75716227929152
annotation: SIP318C854B66FC03B3
annotation: SIPA20ED0FA88A4C46E
annotation: SIP5BF927276E81D490
annotation: SIPADA928A393801B44
annotation: SIP3D1270C59991A78C
annotation: SIP8C17B750CB1F3641
annotation: SIP0EFA20225D2A64D9
annotation: SIPA0F4FCD1A3682BBC
annotation: SIPFD818EF1603E9D18
annotation: SIP64855EBA92A64F67
annotation: SIPE45D8A40AE18EBD4
annotation: SIPBB37B0B7C0AF167D
annotation: SIP295FACC88746665A
annotation: SIP5F0C77D68098483E
annotation: SIP3C049F1E76E7D841
annotation: SIPC180D31251F51B4B
annotation: SIPE295042A2244D89D
existence: Evidence at Transcript Level Existence
classified with: http://purl.uniprot.org/keywords/106
classified with: http://purl.uniprot.org/keywords/256
classified with: http://purl.uniprot.org/keywords/677
classified with: http://purl.uniprot.org/keywords/964
classified with: http://purl.uniprot.org/keywords/732
classified with: GO_0005783
classified with: GO_0005576
classified with: GO_0005509
sequence: Q04732-1

Q04732-citation-1282888
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA]

http://purl.uniprot.org/gene3d/4.10.1080.10
type: Resource
database: Gene3D
comment: TSP type-3 repeat
signature sequence match: Gene3D 4.10.1080.10 match 1
signature sequence match: Gene3D 4.10.1080.10 match 2
signature sequence match: Gene3D 4.10.1080.10 match 3

IPR018247
type: Resource
database: InterPro
comment: EF_Hand_1_Ca_BS

IPR028974
type: Resource
database: InterPro
comment: TSP_type-3_rpt

PTHR37467
type: Resource
database: PANTHER
comment: EXPORTED CALCIUM-BINDING GLYCOPROTEIN-RELATED
signature sequence match: PANTHER PTHR37467 match 1

PTHR37467:SF1
type: Resource
database: PANTHER
comment: EXPORTED CALCIUM-BINDING GLYCOPROTEIN-RELATED
signature sequence match: PANTHER PTHR37467:SF1 match 1

PF18884
type: Resource
database: Pfam
comment: TSP3_bac
signature sequence match: Pfam PF18884 match 1
signature sequence match: Pfam PF18884 match 2
signature sequence match: Pfam PF18884 match 3
signature sequence match: Pfam PF18884 match 4
signature sequence match: Pfam PF18884 match 5
signature sequence match: Pfam PF18884 match 6
signature sequence match: Pfam PF18884 match 7
signature sequence match: Pfam PF18884 match 8
signature sequence match: Pfam PF18884 match 9
signature sequence match: Pfam PF18884 match 10
signature sequence match: Pfam PF18884 match 11
signature sequence match: Pfam PF18884 match 12
signature sequence match: Pfam PF18884 match 13
signature sequence match: Pfam PF18884 match 14
signature sequence match: Pfam PF18884 match 15
signature sequence match: Pfam PF18884 match 16
signature sequence match: Pfam PF18884 match 17
signature sequence match: Pfam PF18884 match 18
signature sequence match: Pfam PF18884 match 19
signature sequence match: Pfam PF18884 match 20
signature sequence match: Pfam PF18884 match 21
signature sequence match: Pfam PF18884 match 22
signature sequence match: Pfam PF18884 match 23

PS00018
type: Resource
database: PROSITE
comment: EF_HAND_1
signature sequence match: PROSITE PS00018 match 1
signature sequence match: PROSITE PS00018 match 2
signature sequence match: PROSITE PS00018 match 3
signature sequence match: PROSITE PS00018 match 4

SIPDB4D59E398EEA89B
type: Structured Name
full name: Calcium-binding acidic-repeat protein
short name: ARP

SIPEC0CD2317821AEBA
type: Function Annotation
comment: May function as a calcium-binding protein.

SIPBCF586A40FC69934
type: Signal Peptide Annotation
comment: Or 23
range: 22852473936097838tt1tt20

22852473936097838tt1
type: Position
type: ExactPosition
position: 1
reference: Q04732-1

22852473936097838tt20
type: Position
type: ExactPosition
position: 20
reference: Q04732-1

PRO_0000020757
type: Chain Annotation
comment: Calcium-binding acidic-repeat protein
mass: 71210
range: 22852473936097838tt21tt695

22852473936097838tt21
type: Position
type: ExactPosition
position: 21
reference: Q04732-1

22852473936097838tt695
type: Position
type: ExactPosition
position: 695
reference: Q04732-1

SIP01D22668BDA3DBBB
type: Repeat Annotation
comment: TSP type-3 1
range: 22852473936097838tt24tt38

22852473936097838tt24
type: Position
type: ExactPosition
position: 24
reference: Q04732-1

22852473936097838tt38
type: Position
type: ExactPosition
position: 38
reference: Q04732-1

SIPD719BEF7E2D73816
type: Repeat Annotation
comment: TSP type-3 2
range: 22852473936097838tt47tt56

22852473936097838tt47
type: Position
type: ExactPosition
position: 47
reference: Q04732-1

22852473936097838tt56
type: Position
type: ExactPosition
position: 56
reference: Q04732-1

SIP01FFDACC5948105E
type: Repeat Annotation
comment: TSP type-3 3
range: 22852473936097838tt70tt82

22852473936097838tt70
type: Position
type: ExactPosition
position: 70
reference: Q04732-1

22852473936097838tt82
type: Position
type: ExactPosition
position: 82
reference: Q04732-1

SIPE3093A8E7AE23C4D
type: Repeat Annotation
comment: TSP type-3 4
range: 22852473936097838tt184tt196

22852473936097838tt184
type: Position
type: ExactPosition
position: 184
reference: Q04732-1

22852473936097838tt196
type: Position
type: ExactPosition
position: 196
reference: Q04732-1

SIP49A0FC6CBEB4E686
type: Repeat Annotation
comment: TSP type-3 5
range: 22852473936097838tt202tt214

22852473936097838tt202
type: Position
type: ExactPosition
position: 202
reference: Q04732-1

22852473936097838tt214
type: Position
type: ExactPosition
position: 214
reference: Q04732-1

SIP22597D9D0020554D
type: Repeat Annotation
comment: TSP type-3 6
range: 22852473936097838tt248tt260

22852473936097838tt248
type: Position
type: ExactPosition
position: 248
reference: Q04732-1

22852473936097838tt260
type: Position
type: ExactPosition
position: 260
reference: Q04732-1

SIP1A68C4EF3BF5EB90
type: Repeat Annotation
comment: TSP type-3 7
range: 22852473936097838tt294tt308

22852473936097838tt294
type: Position
type: ExactPosition
position: 294
reference: Q04732-1

22852473936097838tt308
type: Position
type: ExactPosition
position: 308
reference: Q04732-1

SIP02E61BB6CF35052C
type: Repeat Annotation
comment: TSP type-3 8
range: 22852473936097838tt317tt329

22852473936097838tt317
type: Position
type: ExactPosition
position: 317
reference: Q04732-1

22852473936097838tt329
type: Position
type: ExactPosition
position: 329
reference: Q04732-1

SIPB2BD8C6136AFC0FF
type: Repeat Annotation
comment: TSP type-3 9
range: 22852473936097838tt340tt352

22852473936097838tt340
type: Position
type: ExactPosition
position: 340
reference: Q04732-1

22852473936097838tt352
type: Position
type: ExactPosition
position: 352
reference: Q04732-1

SIPCAD4D53CDAA9F15D
type: Repeat Annotation
comment: TSP type-3 10
range: 22852473936097838tt363tt375

22852473936097838tt363
type: Position
type: ExactPosition
position: 363
reference: Q04732-1

22852473936097838tt375
type: Position
type: ExactPosition
position: 375
reference: Q04732-1

SIPB06FBAEE32ECFE50
type: Repeat Annotation
comment: TSP type-3 11
range: 22852473936097838tt379tt393

22852473936097838tt379
type: Position
type: ExactPosition
position: 379
reference: Q04732-1

22852473936097838tt393
type: Position
type: ExactPosition
position: 393
reference: Q04732-1

SIP82CBE6613C3EDB4C
type: Repeat Annotation
comment: TSP type-3 12
range: 22852473936097838tt402tt414

22852473936097838tt402
type: Position
type: ExactPosition
position: 402
reference: Q04732-1

22852473936097838tt414
type: Position
type: ExactPosition
position: 414
reference: Q04732-1

SIP734915E78D7096D2
type: Repeat Annotation
comment: TSP type-3 13
range: 22852473936097838tt425tt437

22852473936097838tt425
type: Position
type: ExactPosition
position: 425
reference: Q04732-1

22852473936097838tt437
type: Position
type: ExactPosition
position: 437
reference: Q04732-1

SIP2043E7A7C40D3B4C
type: Repeat Annotation
comment: TSP type-3 14
range: 22852473936097838tt470tt482

22852473936097838tt470
type: Position
type: ExactPosition
position: 470
reference: Q04732-1

22852473936097838tt482
type: Position
type: ExactPosition
position: 482
reference: Q04732-1

SIPF04D16A2A9934863
type: Repeat Annotation
comment: TSP type-3 15
range: 22852473936097838tt493tt505

22852473936097838tt493
type: Position
type: ExactPosition
position: 493
reference: Q04732-1

22852473936097838tt505
type: Position
type: ExactPosition
position: 505
reference: Q04732-1

SIP7C75716227929152
type: Repeat Annotation
comment: TSP type-3 16
range: 22852473936097838tt516tt528

22852473936097838tt516
type: Position
type: ExactPosition
position: 516
reference: Q04732-1

22852473936097838tt528
type: Position
type: ExactPosition
position: 528
reference: Q04732-1

SIP318C854B66FC03B3
type: Repeat Annotation
comment: TSP type-3 17
range: 22852473936097838tt539tt551

22852473936097838tt539
type: Position
type: ExactPosition
position: 539
reference: Q04732-1

22852473936097838tt551
type: Position
type: ExactPosition
position: 551
reference: Q04732-1

SIPA20ED0FA88A4C46E
type: Repeat Annotation
comment: TSP type-3 18
range: 22852473936097838tt555tt569

22852473936097838tt555
type: Position
type: ExactPosition
position: 555
reference: Q04732-1

22852473936097838tt569
type: Position
type: ExactPosition
position: 569
reference: Q04732-1

SIP5BF927276E81D490
type: Repeat Annotation
comment: TSP type-3 19
range: 22852473936097838tt600tt609

22852473936097838tt600
type: Position
type: ExactPosition
position: 600
reference: Q04732-1

22852473936097838tt609
type: Position
type: ExactPosition
position: 609
reference: Q04732-1

SIPADA928A393801B44
type: Repeat Annotation
comment: TSP type-3 20
range: 22852473936097838tt623tt635

22852473936097838tt623
type: Position
type: ExactPosition
position: 623
reference: Q04732-1

22852473936097838tt635
type: Position
type: ExactPosition
position: 635
reference: Q04732-1

SIP3D1270C59991A78C
type: Repeat Annotation
comment: TSP type-3 21
range: 22852473936097838tt646tt658

22852473936097838tt646
type: Position
type: ExactPosition
position: 646
reference: Q04732-1

22852473936097838tt658
type: Position
type: ExactPosition
position: 658
reference: Q04732-1

SIP8C17B750CB1F3641
type: Region Annotation
comment: Disordered
range: 22852473936097838tt45tt695

22852473936097838tt45
type: Position
type: ExactPosition
position: 45
reference: Q04732-1

SIP0EFA20225D2A64D9
type: Compositional Bias Annotation
comment: Basic and acidic residues
range: 22852473936097838tt55tt74

22852473936097838tt55
type: Position
type: ExactPosition
position: 55
reference: Q04732-1

22852473936097838tt74
type: Position
type: ExactPosition
position: 74
reference: Q04732-1

SIPA0F4FCD1A3682BBC
type: Compositional Bias Annotation
comment: Basic and acidic residues
range: 22852473936097838tt180tt223

22852473936097838tt180
type: Position
type: ExactPosition
position: 180
reference: Q04732-1

22852473936097838tt223
type: Position
type: ExactPosition
position: 223
reference: Q04732-1

SIPFD818EF1603E9D18
type: Compositional Bias Annotation
comment: Basic and acidic residues
range: 22852473936097838tt232tt249

22852473936097838tt232
type: Position
type: ExactPosition
position: 232
reference: Q04732-1

22852473936097838tt249
type: Position
type: ExactPosition
position: 249
reference: Q04732-1

SIP64855EBA92A64F67
type: Compositional Bias Annotation
comment: Basic and acidic residues
range: 22852473936097838tt280tt294

22852473936097838tt280
type: Position
type: ExactPosition
position: 280
reference: Q04732-1

SIPE45D8A40AE18EBD4
type: Compositional Bias Annotation
comment: Acidic residues
range: 22852473936097838tt309tt325

22852473936097838tt309
type: Position
type: ExactPosition
position: 309
reference: Q04732-1

22852473936097838tt325
type: Position
type: ExactPosition
position: 325
reference: Q04732-1

SIPBB37B0B7C0AF167D
type: Compositional Bias Annotation
comment: Basic and acidic residues
range: 22852473936097838tt326tt363

22852473936097838tt326
type: Position
type: ExactPosition
position: 326
reference: Q04732-1

SIP295FACC88746665A
type: Compositional Bias Annotation
comment: Polar residues
range: 22852473936097838tt444tt461

22852473936097838tt444
type: Position
type: ExactPosition
position: 444
reference: Q04732-1

22852473936097838tt461
type: Position
type: ExactPosition
position: 461
reference: Q04732-1

SIP5F0C77D68098483E
type: Compositional Bias Annotation
comment: Basic and acidic residues
range: 22852473936097838tt479tt493

22852473936097838tt479
type: Position
type: ExactPosition
position: 479
reference: Q04732-1

SIP3C049F1E76E7D841
type: Compositional Bias Annotation
comment: Basic and acidic residues
range: 22852473936097838tt526tt576

22852473936097838tt526
type: Position
type: ExactPosition
position: 526
reference: Q04732-1

22852473936097838tt576
type: Position
type: ExactPosition
position: 576
reference: Q04732-1

SIPC180D31251F51B4B
type: Compositional Bias Annotation
comment: Basic and acidic residues
range: 22852473936097838tt585tt607

22852473936097838tt585
type: Position
type: ExactPosition
position: 585
reference: Q04732-1

22852473936097838tt607
type: Position
type: ExactPosition
position: 607
reference: Q04732-1

SIPE295042A2244D89D
type: Compositional Bias Annotation
comment: Basic and acidic residues
range: 22852473936097838tt665tt680

22852473936097838tt665
type: Position
type: ExactPosition
position: 665
reference: Q04732-1

22852473936097838tt680
type: Position
type: ExactPosition
position: 680
reference: Q04732-1

Q04732-1
type: Simple Sequence
modified: 1993-10-01
version: 1
precursor: true
mass: 73543
value: MSHLWCWLFLVLCLACLVLSIEAKDSDGDGLLDVDEINVYFTDPYNADSDQDGLTDGLEVNRHQTHPQDKDTDDDSIGDGVEVNNLGTNPKDPDSDDDGLTDGAEVNLYRTDPLDADSTTTGCPMGGGAEVRHRPQNGDTDDDGLTDGAEVNVHRTNPQDGDSDDDGLSDGAEVNTYHSNPKDGDSDDDGVSDGAEVNPKLKDSDGDGLTDEEEIKLYRTDPFCADSDFDGLLDGEEVKVHKTNPLDGDSDDDGLGDGAEVTHFNTNPLDADSDNDGLDDGEEINVHGTDPEDPDSDNDGLNDGDEVNVYNTDPEEDDSDEDGVCDGAEVNVHHTNPKDEDSDNDGIPDGAEINTHKTDPNDEDSDDDGIADGAEVTLTDSDGDGLPDEDEVALYNTNPANADSDYDGLTDGAEVKRYQSNPLDKDTDDDGLGDGVEVTVGTDPHDATVTTTGSRTAVEINVHGSDPNDEDTDDDGLTDGAEVNLHRTDPEDADTDDDGLTDGAEVNTYRTNPKLADSDGDGLSDGAEVNTHKSDPNDGDSDDDGVPDAAEAKVKDSDGDGLSDTDEVRFRTNPKLADTDFDGLTDGAEILKHKTDPRNRDTDGDGVADGLEVNTYGSDPKDADTDDDGLTDGAEINVHDTNPTDADSDDDGLSDGAEVMTYHTNAKDGDSDDDGKADGAEVSASTDPWRSDHSV

http://purl.uniprot.org/uniprot/Q04732#attribution-DC036A124EC8E88DF072B29F6D9BB9FE
manual: true
evidence: ECO_0000255

A4H6J5
type: Protein
reviewed: true
created: 2009-11-03
modified: 2023-02-22
version: 83
mnemonic: ASNA_LEIBR
citation: http://purl.uniprot.org/citations/17572675
recommended name: SIPB4966B1FED2D3535
alternative name: SIPCBBE28D26C15E422
alternative name: SIPD84B9906671FBF1B
enzyme: http://purl.uniprot.org/enzyme/3.6.-.-
organism: http://purl.uniprot.org/taxonomy/5660
annotation: SIPC4F208697723F5AA
annotation: SIPC7E26BE26410973A
annotation: SIPD6C6B9FD0DA9A071
annotation: SIPC105BC1330A59FC2
annotation: PRO_0000388177
annotation: SIPD315E758648A8639
annotation: SIP81F670D4C03460B8
annotation: SIP79F220B882D1BC4B
annotation: SIP347CE183001493CD
annotation: SIP120834FF6B0A0083
annotation: SIPD5DBDA7D9C02619E
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/256
classified with: http://purl.uniprot.org/keywords/378
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/813
classified with: http://purl.uniprot.org/keywords/862
classified with: GO_0005783
classified with: GO_0005524
classified with: GO_0016887
classified with: GO_0046872
classified with: GO_0045048
sequence: A4H6J5-1
proteome: Chromosome 11

A4H6J5-citation-17572675
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

MHOM/BR/75/M2904
type: Strain

cd02035
type: Resource
database: CDD
comment: ArsA
signature sequence match: CDD cd02035 match 1

http://purl.uniprot.org/gene3d/3.40.50.300
type: Resource
database: Gene3D
comment: P-loop containing nucleotide triphosphate hydrolases
signature sequence match: Gene3D 3.40.50.300 match 1
signature sequence match: Gene3D 3.40.50.300 match 2
signature sequence match: Gene3D 3.40.50.300 match 3

MF_03112
type: Resource
database: HAMAP
comment: Asna1_Get3
signature sequence match: HAMAP MF 03112 match 1

IPR025723
type: Resource
database: InterPro
comment: Anion-transp_ATPase-like_dom

IPR016300
type: Resource
database: InterPro
comment: ATPase_ArsA/GET3

IPR027542
type: Resource
database: InterPro
comment: ATPase_ArsA/GET3_euk

IPR027417
type: Resource
database: InterPro
comment: P-loop_NTPase

PTHR10803
type: Resource
database: PANTHER
comment: ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE
signature sequence match: PANTHER PTHR10803 match 1

PTHR10803:SF3
type: Resource
database: PANTHER
comment: ATPASE GET3
signature sequence match: PANTHER PTHR10803:SF3 match 1

PF02374
type: Resource
database: Pfam
comment: ArsA_ATPase
signature sequence match: Pfam PF02374 match 1
signature sequence match: Pfam PF02374 match 2

SSF52540
type: Resource
database: SUPFAM
comment: P-loop containing nucleoside triphosphate hydrolases
signature sequence match: SUPFAM SSF52540 match 1
signature sequence match: SUPFAM SSF52540 match 2

TIGR00345
type: Resource
database: TIGRFAMs
comment: GET3_arsA_TRC40
signature sequence match: TIGRFAMs TIGR00345 match 1

SIPB4966B1FED2D3535
type: Structured Name
full name: ATPase ASNA1 homolog
ec name: 3.6.-.-

SIPCBBE28D26C15E422
type: Structured Name
full name: Arsenical pump-driving ATPase homolog

SIPD84B9906671FBF1B
type: Structured Name
full name: Arsenite-stimulated ATPase

http://purl.uniprot.org/uniprot/A4H6J5#gene-MD53AC2271434377C256A9774924E2F3D51
type: Gene
orf name: LbrM11_V2.0490
orf name: LbrM_11_0490

SIPC4F208697723F5AA
type: Function Annotation
comment: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.

SIPC7E26BE26410973A
type: Subunit Annotation
comment: Homodimer.

SIPC105BC1330A59FC2
type: Similarity Annotation
comment: Belongs to the arsA ATPase family.

PRO_0000388177
type: Chain Annotation
comment: ATPase ASNA1 homolog
mass: 43651
range: 18353358239315246tt1tt406

18353358239315246tt1
type: Position
type: ExactPosition
position: 1
reference: A4H6J5-1

18353358239315246tt406
type: Position
type: ExactPosition
position: 406
reference: A4H6J5-1

18353358239315246tt62
type: Position
type: ExactPosition
position: 62
reference: A4H6J5-1

18353358239315246tt21
type: Position
type: ExactPosition
position: 21
reference: A4H6J5-1

18353358239315246tt28
type: Position
type: ExactPosition
position: 28
reference: A4H6J5-1

18353358239315246tt300
type: Position
type: ExactPosition
position: 300
reference: A4H6J5-1

18353358239315246tt327
type: Position
type: ExactPosition
position: 327
reference: A4H6J5-1

18353358239315246tt339
type: Position
type: ExactPosition
position: 339
reference: A4H6J5-1

18353358239315246tt342
type: Position
type: ExactPosition
position: 342
reference: A4H6J5-1

SIP4C9F4E76B2A96157
subclass of: CHEBI_29105
comment: ligand shared between dimeric partners

A4H6J5-1
type: Simple Sequence
modified: 2007-05-01
version: 1
mass: 43651
value: MDPTLTELLHSNLQWIFVGGKGGVGKTTTSCALATLFATTPISDAAAPDGTRPRRVLLISTDPAHNLSDAFNQRFGPQPTPVKGLEDTLAAMEVDPKNFTHGALMSSLTGANSGGSASSLSREAEADAVEQTASFARIGAVLKEAARTMPGIDEISVFAEILHYVRTLSYDLLIFDTAPTGHTLRLLALPQTLNSTFDRLMSLEGLAPMLEAASHLIGSSLGAVGGDSVSGCEVATAMPSSSSTAPGAGSAATGSSQGSWSITADEVRAKALHWRQVMEEVQDRFNDPSRTSFVCVCIAEFLSVYETERLVQELMKYNIGCDSIVVNQLVLKPSSEPPCRMCAARQKIQTKYLEQIDLLYDDFHVVKMPLLSDEVRGIPALKMFARFLQEPYNPDTHGYIDVQESC

http://purl.uniprot.org/uniprot/A4H6J5#attribution-112ECABA3446E816E3B0A6A072E546C4
manual: true
evidence: ECO_0000255
source: MF_03112

A4HUY0
type: Protein
reviewed: true
created: 2009-11-03
modified: 2023-02-22
version: 78
mnemonic: ASNA_LEIIN
citation: http://purl.uniprot.org/citations/17572675
recommended name: SIPB4966B1FED2D3535
alternative name: SIPCBBE28D26C15E422
alternative name: SIPD84B9906671FBF1B
enzyme: http://purl.uniprot.org/enzyme/3.6.-.-
organism: http://purl.uniprot.org/taxonomy/5671
annotation: SIPD763181CCBACF3FE
annotation: SIPE6AE45FC73BE8588
annotation: SIP0DEE995A8E783689
annotation: SIPF48856EDA55D897A
annotation: PRO_0000388178
annotation: SIP05487620CEF86772
annotation: SIP5F6AD406AE6287FA
annotation: SIPDE8DBEDCB3E1C6B6
annotation: SIP11D374CC5C185ED1
annotation: SIP9DA1175829E6220E
annotation: SIP6FB654F631973BAA
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/256
classified with: http://purl.uniprot.org/keywords/378
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/813
classified with: http://purl.uniprot.org/keywords/862
classified with: GO_0005783
classified with: GO_0005524
classified with: GO_0016887
classified with: GO_0046872
classified with: GO_0045048
sequence: A4HUY0-1
proteome: Chromosome 11

A4HUY0-citation-17572675
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

JPCM5
type: Strain

KOG2825
type: Resource
database: eggNOG
comment: Eukaryota

SIPB4966B1FED2D3535
type: Structured Name
full name: ATPase ASNA1 homolog
ec name: 3.6.-.-

SIPCBBE28D26C15E422
type: Structured Name
full name: Arsenical pump-driving ATPase homolog

SIPD84B9906671FBF1B
type: Structured Name
full name: Arsenite-stimulated ATPase

http://purl.uniprot.org/uniprot/A4HUY0#gene-MD5ECFA5EA317DB130A0A04BB26955DC78D
type: Gene
orf name: LinJ11.0710
orf name: LinJ_11_0710

SIPD763181CCBACF3FE
type: Function Annotation
comment: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.

SIPE6AE45FC73BE8588
type: Subunit Annotation
comment: Homodimer.

SIPF48856EDA55D897A
type: Similarity Annotation
comment: Belongs to the arsA ATPase family.

PRO_0000388178
type: Chain Annotation
comment: ATPase ASNA1 homolog
mass: 43982
range: 18353358760390702tt1tt409

18353358760390702tt1
type: Position
type: ExactPosition
position: 1
reference: A4HUY0-1

18353358760390702tt409
type: Position
type: ExactPosition
position: 409
reference: A4HUY0-1

18353358760390702tt62
type: Position
type: ExactPosition
position: 62
reference: A4HUY0-1

18353358760390702tt21
type: Position
type: ExactPosition
position: 21
reference: A4HUY0-1

18353358760390702tt28
type: Position
type: ExactPosition
position: 28
reference: A4HUY0-1

18353358760390702tt303
type: Position
type: ExactPosition
position: 303
reference: A4HUY0-1

18353358760390702tt330
type: Position
type: ExactPosition
position: 330
reference: A4HUY0-1

18353358760390702tt342
type: Position
type: ExactPosition
position: 342
reference: A4HUY0-1

18353358760390702tt345
type: Position
type: ExactPosition
position: 345
reference: A4HUY0-1

SIP4C9F4E76B2A96157
subclass of: CHEBI_29105
comment: ligand shared between dimeric partners

A4HUY0-1
type: Simple Sequence
modified: 2007-05-01
version: 1
mass: 43982
value: MDPTLTELLHANLEWIFVGGKGGVGKTTTSCALATLFATTPISDAASPGGTRPRRVLLISTDPAHNLSDAFNQRFGPHPTPVKGLEESLAAMEVDPKNFTHGALMSSLTGTKRDGSASSLPEEAAADAAQHTTTFARIGAVLKEAARTMPGIDEISVFAEILHYVRTLSYDLLIFDTAPTGHTLRLLALPQTLNSTFDKLMSLEGLAPMIEAASHLIGSNLGDLGGACGDTAGSCEQATAAPSPSSAAPGAGSAAAASPQSRWCITADEVRSTALHWRQTMEEVQARFSDPNRTSFVCVCIAEFLSVYETERLVQELMKYNIGCDSIVVNQLVLKPSSEPPCRMCSARQKIQAKYLEQIDLLYEDFHVVKMPLLSDEVRGVPALKKFARFLQEPYSPETHGYIDVQEPC

http://purl.uniprot.org/uniprot/A4HUY0#attribution-112ECABA3446E816E3B0A6A072E546C4
manual: true
evidence: ECO_0000255
source: MF_03112

Q4QH08
type: Protein
reviewed: true
created: 2009-11-03
modified: 2023-02-22
version: 84
mnemonic: ASNA_LEIMA
citation: http://purl.uniprot.org/citations/16020728
recommended name: SIPB4966B1FED2D3535
alternative name: SIPCBBE28D26C15E422
alternative name: SIPD84B9906671FBF1B
enzyme: http://purl.uniprot.org/enzyme/3.6.-.-
organism: http://purl.uniprot.org/taxonomy/5664
annotation: SIP76E74798E3549C2C
annotation: SIP7D6B665094153CA5
annotation: SIP64E6289778D6311E
annotation: SIP64429D72F0CDB130
annotation: PRO_0000388179
annotation: SIP217E15EAF1DF9ECE
annotation: SIP6C077E54BB26CC39
annotation: SIP05F9F558C04A1E9D
annotation: SIP4A54742EB402FFB3
annotation: SIP3039178A0DEDFE0B
annotation: SIPDCA7D279B7D6DBB2
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/256
classified with: http://purl.uniprot.org/keywords/378
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/813
classified with: http://purl.uniprot.org/keywords/862
classified with: GO_0043529
classified with: GO_0005524
classified with: GO_0016887
classified with: GO_0046872
classified with: GO_0006620
classified with: GO_0045048
sequence: Q4QH08-1
proteome: Chromosome 11

Q4QH08-citation-16020728
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

MHOM/IL/81/Friedlin
type: Strain

SIPB4966B1FED2D3535
type: Structured Name
full name: ATPase ASNA1 homolog
ec name: 3.6.-.-

SIPCBBE28D26C15E422
type: Structured Name
full name: Arsenical pump-driving ATPase homolog

SIPD84B9906671FBF1B
type: Structured Name
full name: Arsenite-stimulated ATPase

http://purl.uniprot.org/uniprot/Q4QH08#gene-MD5484C5235D02E0A70DA84F41A233B6E32
type: Gene
orf name: LmjF11.0700
orf name: LmjF_11_0700

SIP76E74798E3549C2C
type: Function Annotation
comment: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.

SIP7D6B665094153CA5
type: Subunit Annotation
comment: Homodimer.

SIP64429D72F0CDB130
type: Similarity Annotation
comment: Belongs to the arsA ATPase family.

PRO_0000388179
type: Chain Annotation
comment: ATPase ASNA1 homolog
mass: 43936
range: 22856996821678126tt1tt409

22856996821678126tt1
type: Position
type: ExactPosition
position: 1
reference: Q4QH08-1

22856996821678126tt409
type: Position
type: ExactPosition
position: 409
reference: Q4QH08-1

22856996821678126tt62
type: Position
type: ExactPosition
position: 62
reference: Q4QH08-1

22856996821678126tt21
type: Position
type: ExactPosition
position: 21
reference: Q4QH08-1

22856996821678126tt28
type: Position
type: ExactPosition
position: 28
reference: Q4QH08-1

22856996821678126tt303
type: Position
type: ExactPosition
position: 303
reference: Q4QH08-1

22856996821678126tt330
type: Position
type: ExactPosition
position: 330
reference: Q4QH08-1

22856996821678126tt342
type: Position
type: ExactPosition
position: 342
reference: Q4QH08-1

22856996821678126tt345
type: Position
type: ExactPosition
position: 345
reference: Q4QH08-1

SIP4C9F4E76B2A96157
subclass of: CHEBI_29105
comment: ligand shared between dimeric partners

Q4QH08-1
type: Simple Sequence
modified: 2005-07-19
version: 1
mass: 43936
value: MDPTLKELLHANLEWIFVGGKGGVGKTTTSCALATLFATTPISDAASPGGTRPRRVLLISTDPAHNLSDAFNQRFGPHPTPVKGLEESLAAMEVDPKNFTHGALMSSLTGAKSDGSASSLSAEAEADAAQHTASFARIGAVLKEAARTMPGIDEISVFAEILHYVRTLFYDLLIFDTAPTGHTLRLLALPQTLSSTFDKLMSLEGLAPMIEAASHLIGTNLGALGGACGDTAGSCEQATAAPSLSSAAPGEGSAAAASSQSRWCITADEVRSTALHWRQTMEEVQARFNDPNRTSFVCVCIAEFLSVYETERLVQELMKYNIGCDSIVVNQLVLKPSSEPPCRMCSARQKIQAKYLEQIDLLYEDFHVVKMPLLSDEVRGVPALKKFARFLQEPYSPDTHGYIDVQEPC

http://purl.uniprot.org/uniprot/Q4QH08#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q4QH08#attribution-112ECABA3446E816E3B0A6A072E546C4
manual: true
evidence: ECO_0000255
source: MF_03112

Q4CNH2
type: Protein
reviewed: true
created: 2009-11-03
modified: 2023-02-22
version: 78
mnemonic: ASNA_TRYCC
old mnemonic: ASNA_TRYCR
citation: http://purl.uniprot.org/citations/16020725
recommended name: SIPB4966B1FED2D3535
alternative name: SIPCBBE28D26C15E422
alternative name: SIPD84B9906671FBF1B
enzyme: http://purl.uniprot.org/enzyme/3.6.-.-
organism: http://purl.uniprot.org/taxonomy/353153
annotation: SIP22455BF5C213D0DF
annotation: SIP2B75D42EF7732DC3
annotation: SIP3AAC85B81A310A0E
annotation: SIP26B0C7675EC0E019
annotation: PRO_0000388180
annotation: SIPE9705FC21915F5B1
annotation: SIP1BF3ADF019E56011
annotation: SIP833245EBA2BFEBD9
annotation: SIP07B3FADAD449E285
annotation: SIPAB0629B148277E31
annotation: SIP023F684D8589491D
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/256
classified with: http://purl.uniprot.org/keywords/378
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/813
classified with: http://purl.uniprot.org/keywords/862
classified with: GO_0005783
classified with: GO_0005524
classified with: GO_0016887
classified with: GO_0046872
classified with: GO_0045048
sequence: Q4CNH2-1
proteome: Unassembled WGS sequence

Q4CNH2-citation-16020725
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

CL Brener
type: Strain

SIPB4966B1FED2D3535
type: Structured Name
full name: ATPase ASNA1 homolog
ec name: 3.6.-.-

SIPCBBE28D26C15E422
type: Structured Name
full name: Arsenical pump-driving ATPase homolog

SIPD84B9906671FBF1B
type: Structured Name
full name: Arsenite-stimulated ATPase

http://purl.uniprot.org/uniprot/Q4CNH2#gene-MD53EDE27D758E3123464327A9753BCAC83
type: Gene
orf name: Tc00.1047053507763.30

http://purl.uniprot.org/uniprot/Q4CNH2#gene-MD5783C068D50A7C996E057AC348CC5F28E
type: Gene
orf name: Tc00.1047053510101.490

SIP22455BF5C213D0DF
type: Function Annotation
comment: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.

SIP2B75D42EF7732DC3
type: Subunit Annotation
comment: Homodimer.

SIP26B0C7675EC0E019
type: Similarity Annotation
comment: Belongs to the arsA ATPase family.

PRO_0000388180
type: Chain Annotation
comment: ATPase ASNA1 homolog
mass: 39244
range: 22856936794370606tt1tt359

22856936794370606tt1
type: Position
type: ExactPosition
position: 1
reference: Q4CNH2-1

22856936794370606tt359
type: Position
type: ExactPosition
position: 359
reference: Q4CNH2-1

22856936794370606tt63
type: Position
type: ExactPosition
position: 63
reference: Q4CNH2-1

22856936794370606tt23
type: Position
type: ExactPosition
position: 23
reference: Q4CNH2-1

22856936794370606tt30
type: Position
type: ExactPosition
position: 30
reference: Q4CNH2-1

22856936794370606tt252
type: Position
type: ExactPosition
position: 252
reference: Q4CNH2-1

22856936794370606tt279
type: Position
type: ExactPosition
position: 279
reference: Q4CNH2-1

22856936794370606tt291
type: Position
type: ExactPosition
position: 291
reference: Q4CNH2-1

22856936794370606tt294
type: Position
type: ExactPosition
position: 294
reference: Q4CNH2-1

SIP4C9F4E76B2A96157
subclass of: CHEBI_29105
comment: ligand shared between dimeric partners

Q4CNH2-1
type: Simple Sequence
modified: 2005-09-13
version: 1
mass: 39244
value: MSLEPTLRDLLHSKLQWIFVGGKGGVGKTTTSCALATLFASTPVHDAVTNTTRPRRVLLISTDPAHNLSDAFSQKFGKTPVPVNGMEETLFAMEVDPTTFTHGGFGAMLGFPGHIATDADAPSPFAALGNILKEAAGTLPGIDELSVFAEILRGVQQLSYDVVIFDTAPTGHTLRLLALPHTLNSTMEKLLSVEGLNTLIQAASAVLSSTTNLGDMSSLMPAFKQWRENVQEVQRQFTDAEKTAFICVCIPEFLSVYETERLVQELMKYDISCDSIVVNQLVLKPSSEPDCRMCNARQKIQSKYLAQIDSLYEDFHVVKMPLLSDEVRGVPALQRFAQFLLEPYDADRHGYIDVCGAAS

http://purl.uniprot.org/uniprot/Q4CNH2#attribution-112ECABA3446E816E3B0A6A072E546C4
manual: true
evidence: ECO_0000255
source: MF_03112

Q4CQJ5
type: Protein
reviewed: true
created: 2010-11-30
modified: 2023-05-03
version: 73
mnemonic: ATAT1_TRYCC
old mnemonic: ATAT1_TRYCR
old mnemonic: MC171_TRYCR
citation: http://purl.uniprot.org/citations/16020725
recommended name: SIP28DE56439D6F64AA
alternative name: SIP94A46C0377DFB1D0
enzyme: http://purl.uniprot.org/enzyme/2.3.1.108
organism: http://purl.uniprot.org/taxonomy/353153
annotation: SIPD28F35250F50F4DD
annotation: SIP592687D381EB714E
annotation: SIPDB2B6F12626538C3
annotation: PRO_0000402086
annotation: SIP81F5F4C18B9417AC
annotation: SIPF9729544B20A3DC6
annotation: SIP2F8499DEF26F6E8E
annotation: SIP72CD25C88A376FFC
annotation: SIPF19BEF8F3E6ED3AE
annotation: SIPEB2ECDA70C1AD30A
annotation: SIP2BE9EB208806BDD2
annotation: SIP47ED4CD3E77E4797
annotation: SIP3009507D99E2C49A
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/12
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005874
classified with: GO_0003700
classified with: GO_0043565
classified with: GO_0019799
classified with: GO_0071929
classified with: GO_0070507
sequence: Q4CQJ5-1
proteome: Unassembled WGS sequence

Q4CQJ5-citation-16020725
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

CL Brener
type: Strain

KOG4601
type: Resource
database: eggNOG
comment: Eukaryota

MF_03130
type: Resource
database: HAMAP
comment: mec17
signature sequence match: HAMAP MF 03130 match 1

IPR038746
type: Resource
database: InterPro
comment: Atat

IPR007965
type: Resource
database: InterPro
comment: GNAT_ATAT

IPR003657
type: Resource
database: InterPro
comment: WRKY_dom

PTHR12327:SF0
type: Resource
database: PANTHER
comment: ALPHA-TUBULIN N-ACETYLTRANSFERASE 1
signature sequence match: PANTHER PTHR12327:SF0 match 1

PTHR12327
type: Resource
database: PANTHER
comment: UNCHARACTERIZED
signature sequence match: PANTHER PTHR12327 match 1

PF05301
type: Resource
database: Pfam
comment: Acetyltransf_16
signature sequence match: Pfam PF05301 match 1

PS51730
type: Resource
database: PROSITE
comment: GNAT_ATAT
signature sequence match: PROSITE PS51730 match 1

SIP28DE56439D6F64AA
type: Structured Name
full name: Alpha-tubulin N-acetyltransferase 1
short name: Alpha-TAT 1
short name: TAT 1
ec name: 2.3.1.108

SIP94A46C0377DFB1D0
type: Structured Name
full name: Acetyltransferase mec-17 homolog 1

http://purl.uniprot.org/uniprot/Q4CQJ5#gene-MD5FA9C06555F9A2C06603C280473F08992
type: Gene
orf name: Tc00.1047053467287.10

SIPD28F35250F50F4DD
type: Function Annotation
comment: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.

SIPDB2B6F12626538C3
type: Similarity Annotation
comment: Belongs to the acetyltransferase ATAT1 family.

PRO_0000402086
type: Chain Annotation
comment: Alpha-tubulin N-acetyltransferase 1
mass: 36884
range: 22856936844834094tt1tt329

22856936844834094tt1
type: Position
type: ExactPosition
position: 1
reference: Q4CQJ5-1

22856936844834094tt329
type: Position
type: ExactPosition
position: 329
reference: Q4CQJ5-1

SIP81F5F4C18B9417AC
type: Domain Extent Annotation
comment: N-acetyltransferase
range: 22856936844834094tt5tt185

22856936844834094tt5
type: Position
type: ExactPosition
position: 5
reference: Q4CQJ5-1

22856936844834094tt185
type: Position
type: ExactPosition
position: 185
reference: Q4CQJ5-1

SIPF9729544B20A3DC6
type: Region Annotation
comment: Disordered
range: 22856936844834094tt218tt261

22856936844834094tt218
type: Position
type: ExactPosition
position: 218
reference: Q4CQJ5-1

22856936844834094tt261
type: Position
type: ExactPosition
position: 261
reference: Q4CQJ5-1

SIP2F8499DEF26F6E8E
type: Region Annotation
comment: Disordered
range: 22856936844834094tt306tt329

22856936844834094tt306
type: Position
type: ExactPosition
position: 306
reference: Q4CQJ5-1

SIP72CD25C88A376FFC
type: Compositional Bias Annotation
comment: Polar residues
range: 22856936844834094tt218tt234

22856936844834094tt234
type: Position
type: ExactPosition
position: 234
reference: Q4CQJ5-1

SIPF19BEF8F3E6ED3AE
type: Compositional Bias Annotation
comment: Pro residues
range: 22856936844834094tt236tt252

22856936844834094tt236
type: Position
type: ExactPosition
position: 236
reference: Q4CQJ5-1

22856936844834094tt252
type: Position
type: ExactPosition
position: 252
reference: Q4CQJ5-1

SIPEB2ECDA70C1AD30A
type: Compositional Bias Annotation
comment: Polar residues
range: 22856936844834094tt314tt329

22856936844834094tt314
type: Position
type: ExactPosition
position: 314
reference: Q4CQJ5-1

22856936844834094tt119
type: Position
type: ExactPosition
position: 119
reference: Q4CQJ5-1

22856936844834094tt132
type: Position
type: ExactPosition
position: 132
reference: Q4CQJ5-1

22856936844834094tt155
type: Position
type: ExactPosition
position: 155
reference: Q4CQJ5-1

22856936844834094tt164
type: Position
type: ExactPosition
position: 164
reference: Q4CQJ5-1

SIP3009507D99E2C49A
type: Site Annotation
comment: Crucial for catalytic activity
range: 22856936844834094tt58tt58

22856936844834094tt58
type: Position
type: ExactPosition
position: 58
reference: Q4CQJ5-1

Q4CQJ5-1
type: Simple Sequence
modified: 2005-09-13
version: 1
mass: 36884
value: MSSTSQVALLPKLSLPDGVTVWDGTALEYERRCNNVDEHAVHLMQTINILGIRSKEAQCLNTVLTSVARLRENRQARVYLLCQDGYGVGILKMGVKKLFVTHPSYSSLVEIDPLCVLDFFVDTSFQRKGFGKTLFDAMLLNEGLNPGEVAIDRPSVKFLAFLQKYYGLVEYTPQSNNFVVFHRYFDKWQPQRGKGHWGGNAVPTRSLVRPQNCLRVYPKYQSTTGPNNNFEEDATHRTPPPPPLPPPLVPQGSVTSPGVGKKTAYELQYEEYLREQAYRRRQGGDPRLQPVPNPVSSSEIVAASCGARRRMSPTRSGVQYNIISGTPEH

http://purl.uniprot.org/uniprot/Q4CQJ5#attribution-8B88553134DA86160391CD6460D31035
manual: true
evidence: ECO_0000255
source: MF_03130

Q4DTX9
type: Protein
reviewed: true
created: 2010-11-30
modified: 2023-05-03
version: 73
mnemonic: ATAT2_TRYCC
old mnemonic: ATAT2_TRYCR
old mnemonic: MC172_TRYCR
citation: http://purl.uniprot.org/citations/16020725
recommended name: SIP5826DBE6862A6F3E
alternative name: SIP489F7794C44916D6
enzyme: http://purl.uniprot.org/enzyme/2.3.1.108
organism: http://purl.uniprot.org/taxonomy/353153
annotation: SIPFAB51B7E20671C87
annotation: SIP31D9EDE34E408368
annotation: SIPF378FFDA3DEF746D
annotation: PRO_0000402087
annotation: SIP3AD0503EE44DE8DA
annotation: SIPACAC37EA92AF7887
annotation: SIP4CD064C15538CD03
annotation: SIP6D8029AD522AF26B
annotation: SIPDD5352251224315C
annotation: SIP05E876930D608C9C
annotation: SIP1F1E9657205A9894
annotation: SIP5E8D1279D8A6EBC9
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/12
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005874
classified with: GO_0003700
classified with: GO_0043565
classified with: GO_0019799
classified with: GO_0071929
classified with: GO_0070507
sequence: Q4DTX9-1
proteome: Unassembled WGS sequence

Q4DTX9-citation-16020725
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

CL Brener
type: Strain

SIP5826DBE6862A6F3E
type: Structured Name
full name: Alpha-tubulin N-acetyltransferase 2
short name: Alpha-TAT 2
short name: TAT 2
ec name: 2.3.1.108

SIP489F7794C44916D6
type: Structured Name
full name: Acetyltransferase mec-17 homolog 2

http://purl.uniprot.org/uniprot/Q4DTX9#gene-MD55733876D5A6C2D57027CB8CACCA76FAC
type: Gene
orf name: Tc00.1047053509233.160

SIPFAB51B7E20671C87
type: Function Annotation
comment: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.

SIPF378FFDA3DEF746D
type: Similarity Annotation
comment: Belongs to the acetyltransferase ATAT1 family.

PRO_0000402087
type: Chain Annotation
comment: Alpha-tubulin N-acetyltransferase 2
mass: 36784
range: 22856941191051566tt1tt328

22856941191051566tt1
type: Position
type: ExactPosition
position: 1
reference: Q4DTX9-1

22856941191051566tt328
type: Position
type: ExactPosition
position: 328
reference: Q4DTX9-1

SIP3AD0503EE44DE8DA
type: Domain Extent Annotation
comment: N-acetyltransferase
range: 22856941191051566tt5tt185

22856941191051566tt5
type: Position
type: ExactPosition
position: 5
reference: Q4DTX9-1

22856941191051566tt185
type: Position
type: ExactPosition
position: 185
reference: Q4DTX9-1

SIPACAC37EA92AF7887
type: Region Annotation
comment: Disordered
range: 22856941191051566tt219tt261

22856941191051566tt219
type: Position
type: ExactPosition
position: 219
reference: Q4DTX9-1

22856941191051566tt261
type: Position
type: ExactPosition
position: 261
reference: Q4DTX9-1

SIP4CD064C15538CD03
type: Region Annotation
comment: Disordered
range: 22856941191051566tt282tt328

22856941191051566tt282
type: Position
type: ExactPosition
position: 282
reference: Q4DTX9-1

SIP6D8029AD522AF26B
type: Compositional Bias Annotation
comment: Pro residues
range: 22856941191051566tt237tt252

22856941191051566tt237
type: Position
type: ExactPosition
position: 237
reference: Q4DTX9-1

22856941191051566tt252
type: Position
type: ExactPosition
position: 252
reference: Q4DTX9-1

SIPDD5352251224315C
type: Compositional Bias Annotation
comment: Polar residues
range: 22856941191051566tt313tt328

22856941191051566tt313
type: Position
type: ExactPosition
position: 313
reference: Q4DTX9-1

22856941191051566tt119
type: Position
type: ExactPosition
position: 119
reference: Q4DTX9-1

22856941191051566tt132
type: Position
type: ExactPosition
position: 132
reference: Q4DTX9-1

22856941191051566tt155
type: Position
type: ExactPosition
position: 155
reference: Q4DTX9-1

22856941191051566tt164
type: Position
type: ExactPosition
position: 164
reference: Q4DTX9-1

SIP5E8D1279D8A6EBC9
type: Site Annotation
comment: Crucial for catalytic activity
range: 22856941191051566tt58tt58

22856941191051566tt58
type: Position
type: ExactPosition
position: 58
reference: Q4DTX9-1

Q4DTX9-1
type: Simple Sequence
modified: 2005-09-13
version: 1
mass: 36784
value: MSSTSQVALLPKLSLPDGVTVWDGTALEYERRCNNIDEHAVHLMQTINILGIRSKEAQCLNTVLTSVARLRENRQARVYLLCQDGYGVGILKMGVKKLFVTHPSYSSLVEIDPLCVLDFFVDTSFQRKGFGKTLFDAMLLNEGLNPGEVAIDRPSVKFLAFLRKYYGLVEYTPQSNNFVVFHRYFDKWQPQRGKGHRGGNAVPTRSIVRPQNCLRVYPEYQSTTGPNDNFEEDATHRTPPPPLPPPLVPQGSVNSPGPGKKTAYELQYEEYLREQAYRRRQGGDPRLQPVPNPVSSSEIAAASCGARRRMSPTRSGVQYNIISGTPEH

http://purl.uniprot.org/uniprot/Q4DTX9#attribution-8B88553134DA86160391CD6460D31035
manual: true
evidence: ECO_0000255
source: MF_03130

A4HE59
type: Protein
reviewed: true
created: 2010-11-30
modified: 2023-05-03
version: 74
mnemonic: ATAT_LEIBR
old mnemonic: MC17_LEIBR
citation: http://purl.uniprot.org/citations/17572675
recommended name: SIP81A0153FE7D546C9
alternative name: SIP8A567449DBA275AD
enzyme: http://purl.uniprot.org/enzyme/2.3.1.108
organism: http://purl.uniprot.org/taxonomy/5660
annotation: SIP6E4A3125034AF652
annotation: SIP3567B40198C56741
annotation: SIP9BDF61D9024F84EC
annotation: PRO_0000402082
annotation: SIP33151A51269C5F86
annotation: SIP9FB1C89988FC763F
annotation: SIP5A6269DB37249A0E
annotation: SIP60D7C0978941626F
annotation: SIPF9FA434E3B1C2906
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/12
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005874
classified with: GO_0019799
classified with: GO_0071929
classified with: GO_0070507
sequence: A4HE59-1
proteome: Chromosome 25

A4HE59-citation-17572675
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

MHOM/BR/75/M2904
type: Strain

cd04301
type: Resource
database: CDD
comment: NAT_SF
signature sequence match: CDD cd04301 match 1

SIP81A0153FE7D546C9
type: Structured Name
full name: Alpha-tubulin N-acetyltransferase
short name: Alpha-TAT
short name: TAT
ec name: 2.3.1.108

SIP8A567449DBA275AD
type: Structured Name
full name: Acetyltransferase mec-17 homolog

http://purl.uniprot.org/uniprot/A4HE59#gene-MD5586C9D631E5F74EDCBDC30B6B5E44D61
type: Gene
orf name: LbrM25_V2.1130
orf name: LbrM_25_1130

SIP6E4A3125034AF652
type: Function Annotation
comment: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.

SIP9BDF61D9024F84EC
type: Similarity Annotation
comment: Belongs to the acetyltransferase ATAT1 family.

PRO_0000402082
type: Chain Annotation
comment: Alpha-tubulin N-acetyltransferase
mass: 25941
range: 18353358489598254tt1tt236

18353358489598254tt1
type: Position
type: ExactPosition
position: 1
reference: A4HE59-1

18353358489598254tt236
type: Position
type: ExactPosition
position: 236
reference: A4HE59-1

SIP33151A51269C5F86
type: Domain Extent Annotation
comment: N-acetyltransferase
range: 18353358489598254tt21tt201

18353358489598254tt21
type: Position
type: ExactPosition
position: 21
reference: A4HE59-1

18353358489598254tt201
type: Position
type: ExactPosition
position: 201
reference: A4HE59-1

SIP9FB1C89988FC763F
type: Region Annotation
comment: Disordered
range: 18353358489598254tt217tt236

18353358489598254tt217
type: Position
type: ExactPosition
position: 217
reference: A4HE59-1

18353358489598254tt134
type: Position
type: ExactPosition
position: 134
reference: A4HE59-1

18353358489598254tt147
type: Position
type: ExactPosition
position: 147
reference: A4HE59-1

18353358489598254tt171
type: Position
type: ExactPosition
position: 171
reference: A4HE59-1

18353358489598254tt180
type: Position
type: ExactPosition
position: 180
reference: A4HE59-1

SIPF9FA434E3B1C2906
type: Site Annotation
comment: Crucial for catalytic activity
range: 18353358489598254tt73tt73

18353358489598254tt73
type: Position
type: ExactPosition
position: 73
reference: A4HE59-1

A4HE59-1
type: Simple Sequence
modified: 2007-05-01
version: 1
mass: 25941
value: MRLSAQLTNTKLADEEVPELASVPDGVSRWTGADLDRLRSAARRGGVGAEQQDLEQKLCRTIDILGARSQKTQGINAVLTSVARLRESNTFRLYLLTQNHRGVGILKMGVKKLFVTHPVTCGLVEVDPLCVLDFYVDESCQRQGYGKQLYAHMLDAEHVSRPELLAIDRPSDKLLGFMKKHYGLTAYTPQVNKFVVFHGFFGHTTVSERGKLLRTTSPTGAAAAATGTKAKNEMPG

http://purl.uniprot.org/uniprot/A4HE59#attribution-8B88553134DA86160391CD6460D31035
manual: true
evidence: ECO_0000255
source: MF_03130

A4I1F7
type: Protein
reviewed: true
created: 2010-11-30
modified: 2023-05-03
version: 71
mnemonic: ATAT_LEIIN
old mnemonic: MC17_LEIIN
citation: http://purl.uniprot.org/citations/17572675
recommended name: SIP81A0153FE7D546C9
alternative name: SIP8A567449DBA275AD
enzyme: http://purl.uniprot.org/enzyme/2.3.1.108
organism: http://purl.uniprot.org/taxonomy/5671
annotation: SIP56D93BB0C22A4131
annotation: SIP1BF29AD857C7BEA0
annotation: SIP48F95262A9A425B8
annotation: PRO_0000402083
annotation: SIP30D10145EFCDED43
annotation: SIP8B77E9135B1DE5F5
annotation: SIP0E11F2DA5C8DB5A6
annotation: SIPAFF2F2549CF8FE64
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/12
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005874
classified with: GO_0019799
classified with: GO_0071929
classified with: GO_0070507
sequence: A4I1F7-1
proteome: Chromosome 25

A4I1F7-citation-17572675
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

JPCM5
type: Strain

SIP81A0153FE7D546C9
type: Structured Name
full name: Alpha-tubulin N-acetyltransferase
short name: Alpha-TAT
short name: TAT
ec name: 2.3.1.108

SIP8A567449DBA275AD
type: Structured Name
full name: Acetyltransferase mec-17 homolog

http://purl.uniprot.org/uniprot/A4I1F7#gene-MD5FCF91E895AB088C23599C991B8C849BA
type: Gene
orf name: LinJ25.1190
orf name: LinJ_25_1190

SIP56D93BB0C22A4131
type: Function Annotation
comment: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.

SIP48F95262A9A425B8
type: Similarity Annotation
comment: Belongs to the acetyltransferase ATAT1 family.

PRO_0000402083
type: Chain Annotation
comment: Alpha-tubulin N-acetyltransferase
mass: 27135
range: 18353362450134830tt1tt246

18353362450134830tt1
type: Position
type: ExactPosition
position: 1
reference: A4I1F7-1

18353362450134830tt246
type: Position
type: ExactPosition
position: 246
reference: A4I1F7-1

SIP30D10145EFCDED43
type: Domain Extent Annotation
comment: N-acetyltransferase
range: 18353362450134830tt21tt202

18353362450134830tt21
type: Position
type: ExactPosition
position: 21
reference: A4I1F7-1

18353362450134830tt202
type: Position
type: ExactPosition
position: 202
reference: A4I1F7-1

18353362450134830tt135
type: Position
type: ExactPosition
position: 135
reference: A4I1F7-1

18353362450134830tt148
type: Position
type: ExactPosition
position: 148
reference: A4I1F7-1

18353362450134830tt172
type: Position
type: ExactPosition
position: 172
reference: A4I1F7-1

18353362450134830tt181
type: Position
type: ExactPosition
position: 181
reference: A4I1F7-1

SIPAFF2F2549CF8FE64
type: Site Annotation
comment: Crucial for catalytic activity
range: 18353362450134830tt74tt74

18353362450134830tt74
type: Position
type: ExactPosition
position: 74
reference: A4I1F7-1

A4I1F7-1
type: Simple Sequence
modified: 2007-05-01
version: 1
mass: 27135
value: MRRRPAQLTATKLADEEVPELTLVPDGVSRWTGADLDALRNAARRGGAEAAQQDLERKLCRTIDILGARSQQAQEINTVLTSVARLRENSTFRLYLLTQNHRGVGILKVGVKKLFVTHPVTCGLVEVDPLCVLDFYVDESCQRQGYGKTLYSHMLKAEHVSRPEVLAIDRPSNKLLGFLRKHYGLAAYTPQVNNFVVFHSFFDHTTVSERGKLLRAPSPARALPFSSSTNATAAIGGAKAKNWAPG

http://purl.uniprot.org/uniprot/A4I1F7#attribution-8B88553134DA86160391CD6460D31035
manual: true
evidence: ECO_0000255
source: MF_03130

Q4Q9X8
type: Protein
reviewed: true
created: 2010-11-30
modified: 2023-05-03
version: 80
mnemonic: ATAT_LEIMA
old mnemonic: MC17_LEIMA
citation: http://purl.uniprot.org/citations/16020728
recommended name: SIP81A0153FE7D546C9
alternative name: SIP8A567449DBA275AD
enzyme: http://purl.uniprot.org/enzyme/2.3.1.108
organism: http://purl.uniprot.org/taxonomy/5664
annotation: SIP1218A04E28CD0AA5
annotation: SIPCC89936C8F20EF1F
annotation: SIP84F0312DAC59A764
annotation: PRO_0000402084
annotation: SIP59DF40B97FD79ED2
annotation: SIPE62929159A90F38D
annotation: SIPBC53AF16D570584F
annotation: SIPD1EC275173E81F69
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/12
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0097014
classified with: GO_0005737
classified with: GO_0005874
classified with: GO_0031981
classified with: GO_0019799
classified with: GO_0071929
classified with: GO_0070507
sequence: Q4Q9X8-1
proteome: Chromosome 25

Q4Q9X8-citation-16020728
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

MHOM/IL/81/Friedlin
type: Strain

SIP81A0153FE7D546C9
type: Structured Name
full name: Alpha-tubulin N-acetyltransferase
short name: Alpha-TAT
short name: TAT
ec name: 2.3.1.108

SIP8A567449DBA275AD
type: Structured Name
full name: Acetyltransferase mec-17 homolog

http://purl.uniprot.org/uniprot/Q4Q9X8#gene-MD5D68AE69D7052E6CA5855F011BF9C9C73
type: Gene
orf name: LmjF25.1150
orf name: LmjF_25_1150

SIP1218A04E28CD0AA5
type: Function Annotation
comment: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.

SIP84F0312DAC59A764
type: Similarity Annotation
comment: Belongs to the acetyltransferase ATAT1 family.

PRO_0000402084
type: Chain Annotation
comment: Alpha-tubulin N-acetyltransferase
mass: 27203
range: 22856996572641326tt1tt246

22856996572641326tt1
type: Position
type: ExactPosition
position: 1
reference: Q4Q9X8-1

22856996572641326tt246
type: Position
type: ExactPosition
position: 246
reference: Q4Q9X8-1

SIP59DF40B97FD79ED2
type: Domain Extent Annotation
comment: N-acetyltransferase
range: 22856996572641326tt21tt202

22856996572641326tt21
type: Position
type: ExactPosition
position: 21
reference: Q4Q9X8-1

22856996572641326tt202
type: Position
type: ExactPosition
position: 202
reference: Q4Q9X8-1

22856996572641326tt135
type: Position
type: ExactPosition
position: 135
reference: Q4Q9X8-1

22856996572641326tt148
type: Position
type: ExactPosition
position: 148
reference: Q4Q9X8-1

22856996572641326tt172
type: Position
type: ExactPosition
position: 172
reference: Q4Q9X8-1

22856996572641326tt181
type: Position
type: ExactPosition
position: 181
reference: Q4Q9X8-1

SIPD1EC275173E81F69
type: Site Annotation
comment: Crucial for catalytic activity
range: 22856996572641326tt74tt74

22856996572641326tt74
type: Position
type: ExactPosition
position: 74
reference: Q4Q9X8-1

Q4Q9X8-1
type: Simple Sequence
modified: 2005-07-19
version: 1
mass: 27203
value: MRRRPPQLTKTKLADEEVPELTLVPDGVSRWTGSDLDALLNAARRGGAEAAQQDLERKLCRTIDILGARSQQAQEINAVLTSVARLRENSTFRLYLLTQNHRGVGILKVGVKKLFVTHPVTCGLVEVDPLCVLDFYVDESCQRQGYGKMLYSHMLKAEHVSRPEVLAIDRPSNKLLGFLRKHYGLAAYTPQVNNFVVFHSFFDHTTVSERGKLLRAPSPARASPFPSSANATVAIGGAKAKNWTPG

http://purl.uniprot.org/uniprot/Q4Q9X8#attribution-0805D343A25D9F44C91CBB2C5680EC43
creator: GeneDB
manual: true
evidence: ECO_0000266

http://purl.uniprot.org/uniprot/Q4Q9X8#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q4Q9X8#attribution-8B88553134DA86160391CD6460D31035
manual: true
evidence: ECO_0000255
source: MF_03130

Q57XX3
type: Protein
reviewed: true
created: 2010-11-30
modified: 2023-05-03
version: 71
mnemonic: ATAT_TRYB2
old mnemonic: ATAT_TRYBB
old mnemonic: MC17_TRYBB
citation: http://purl.uniprot.org/citations/16020726
recommended name: SIP81A0153FE7D546C9
alternative name: SIP8A567449DBA275AD
enzyme: http://purl.uniprot.org/enzyme/2.3.1.108
organism: http://purl.uniprot.org/taxonomy/185431
annotation: SIP2CAA926DA32BF36A
annotation: SIPF8B4BAAE8C8FA8A6
annotation: SIPE440CFB51A713FC5
annotation: PRO_0000402085
annotation: SIP8B87036CDAED2B13
annotation: SIPFD2F70DD98EC6810
annotation: SIP90DFA68B45908260
annotation: SIPC4ECDEE61A79B4C4
annotation: SIP94A0FDB69F56BAC1
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/12
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0097014
classified with: GO_0005737
classified with: GO_0005874
classified with: GO_0031981
classified with: GO_0019799
classified with: GO_0071929
classified with: GO_0070507
sequence: Q57XX3-1
proteome: Chromosome 3

Q57XX3-citation-16020726
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

927/4 GUTat10.1
type: Strain

SIP81A0153FE7D546C9
type: Structured Name
full name: Alpha-tubulin N-acetyltransferase
short name: Alpha-TAT
short name: TAT
ec name: 2.3.1.108

SIP8A567449DBA275AD
type: Structured Name
full name: Acetyltransferase mec-17 homolog

http://purl.uniprot.org/uniprot/Q57XX3#gene-MD57F030F3D622C7E601460A000E8669F7D
type: Gene
orf name: Tb927.3.1400

SIP2CAA926DA32BF36A
type: Function Annotation
comment: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.

SIPE440CFB51A713FC5
type: Similarity Annotation
comment: Belongs to the acetyltransferase ATAT1 family.

PRO_0000402085
type: Chain Annotation
comment: Alpha-tubulin N-acetyltransferase
mass: 37275
range: 22857984935211822tt1tt334

22857984935211822tt1
type: Position
type: ExactPosition
position: 1
reference: Q57XX3-1

22857984935211822tt334
type: Position
type: ExactPosition
position: 334
reference: Q57XX3-1

SIP8B87036CDAED2B13
type: Domain Extent Annotation
comment: N-acetyltransferase
range: 22857984935211822tt1tt186

22857984935211822tt186
type: Position
type: ExactPosition
position: 186
reference: Q57XX3-1

SIPFD2F70DD98EC6810
type: Region Annotation
comment: Disordered
range: 22857984935211822tt314tt334

22857984935211822tt314
type: Position
type: ExactPosition
position: 314
reference: Q57XX3-1

22857984935211822tt120
type: Position
type: ExactPosition
position: 120
reference: Q57XX3-1

22857984935211822tt133
type: Position
type: ExactPosition
position: 133
reference: Q57XX3-1

22857984935211822tt156
type: Position
type: ExactPosition
position: 156
reference: Q57XX3-1

22857984935211822tt165
type: Position
type: ExactPosition
position: 165
reference: Q57XX3-1

SIP94A0FDB69F56BAC1
type: Site Annotation
comment: Crucial for catalytic activity
range: 22857984935211822tt59tt59

22857984935211822tt59
type: Position
type: ExactPosition
position: 59
reference: Q57XX3-1

Q57XX3-1
type: Simple Sequence
modified: 2005-05-10
version: 1
mass: 37275
value: MTHNVMCDDVLPQLNLPDGVTRWNANLLEEERRLRNSDGHADRIILTINTLGKRSKEAQSLNTILTSVPRLRENRDARLYLLCHGGRGVGILKIGVKRLFVVPPSHAGLMEIEPVCVLDFFVDTSNQRQGYGKILFEHMLAFERLSPGDVAIDRPSVKFLAFLRKHYGLVEYTPQSNNFVVFHKYFERHQQQRRGVGGSGRSGYQHCNETTTQQLGTQSGLLEDINQTHPAPSYALRGVVMGHTGPPLDLTNVTQQQKPYHQPFATGRKTSYELQYERYLQSQNCRPTGNAGYGGGNGPASSAEVRATNCQARRRTSPTRSGVPYNIINGSTGS

http://purl.uniprot.org/uniprot/Q57XX3#attribution-F46FC9AB915EBF12BFC88349A3DE91DD
creator: GeneDB
manual: true
evidence: ECO_0000314

http://purl.uniprot.org/uniprot/Q57XX3#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q57XX3#attribution-8B88553134DA86160391CD6460D31035
manual: true
evidence: ECO_0000255
source: MF_03130

http://purl.uniprot.org/uniprot/Q57XX3#attribution-F926B10BF8A9C4F6D60F957D5C681920
manual: true
evidence: ECO_0000312
source: UP000008524

P35315
type: Protein
reviewed: true
created: 1994-02-01
modified: 2023-02-22
version: 120
mnemonic: ATC_TRYBB
old mnemonic: ATC_TRYBR
citation: http://purl.uniprot.org/citations/1833643
recommended name: SIPB163AB89F0DE76CB
alternative name: SIP7F7164377FD02F17
enzyme: http://purl.uniprot.org/enzyme/7.2.2.10
organism: http://purl.uniprot.org/taxonomy/5702
annotation: SIP3FBA7404B0E494AE
annotation: SIPAB08B952BA34F551
annotation: SIP64B156FBB1A03041
annotation: SIP29E1EA6B1A16F14B
annotation: PRO_0000046228
annotation: SIPC775546DABF7F2D0
annotation: SIP1DC29152165BAE72
annotation: SIP6111BB30DA5E389D
annotation: SIP855F7A145E64BEA5
annotation: SIPE4011070FD213BB8
annotation: SIP59B2002325C06CBA
annotation: SIP2B0BB4E19AA9BA25
annotation: SIP6A2C4C59D1C6DF6B
annotation: SIPFBEA317044F53A2A
annotation: SIP278981AB8FBED38C
annotation: SIP824AE22BE5E73964
annotation: SIP2DD28C4BAB4E66A9
annotation: SIP3B56203BA65DCAE3
annotation: SIPE1274DF6F1194978
annotation: SIPD903EFE0814B58E2
annotation: SIPAD6E83C2FEB711F5
annotation: SIPAC25CF8DF84D360E
annotation: SIP636E7CBAA8BD639B
annotation: SIP08C0F03B33E5EE5E
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/109
classified with: http://purl.uniprot.org/keywords/1003
classified with: http://purl.uniprot.org/keywords/460
classified with: http://purl.uniprot.org/keywords/597
classified with: http://purl.uniprot.org/keywords/1278
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0020016
classified with: GO_0005886
classified with: GO_0005524
classified with: GO_0016887
classified with: GO_0005388
sequence: P35315-1

P35315-citation-1833643
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

http://purl.uniprot.org/gene3d/3.40.1110.10
type: Resource
database: Gene3D
comment: Calcium-transporting ATPase, cytoplasmic domain N
signature sequence match: Gene3D 3.40.1110.10 match 1

http://purl.uniprot.org/gene3d/2.70.150.10
type: Resource
database: Gene3D
comment: Calcium-transporting ATPase, cytoplasmic transduction domain A
signature sequence match: Gene3D 2.70.150.10 match 1

http://purl.uniprot.org/gene3d/1.20.1110.10
type: Resource
database: Gene3D
comment: Calcium-transporting ATPase, transmembrane domain
signature sequence match: Gene3D 1.20.1110.10 match 1

http://purl.uniprot.org/gene3d/3.40.50.1000
type: Resource
database: Gene3D
comment: HAD superfamily/HAD-like
signature sequence match: Gene3D 3.40.50.1000 match 1

IPR006068
type: Resource
database: InterPro
comment: ATPase_P-typ_cation-transptr_C

IPR004014
type: Resource
database: InterPro
comment: ATPase_P-typ_cation-transptr_N

IPR023299
type: Resource
database: InterPro
comment: ATPase_P-typ_cyto_dom_N

IPR018303
type: Resource
database: InterPro
comment: ATPase_P-typ_P_site

IPR023298
type: Resource
database: InterPro
comment: ATPase_P-typ_TM_dom_sf

IPR008250
type: Resource
database: InterPro
comment: ATPase_P-typ_transduc_dom_A_sf

IPR036412
type: Resource
database: InterPro
comment: HAD-like_sf

IPR023214
type: Resource
database: InterPro
comment: HAD_sf

IPR005782
type: Resource
database: InterPro
comment: P-type_ATPase_IIA

IPR001757
type: Resource
database: InterPro
comment: P_typ_ATPase

IPR044492
type: Resource
database: InterPro
comment: P_typ_ATPase_HD_dom

PTHR42861
type: Resource
database: PANTHER
comment: CALCIUM-TRANSPORTING ATPASE
signature sequence match: PANTHER PTHR42861 match 1

PTHR42861:SF102
type: Resource
database: PANTHER
comment: CALCIUM-TRANSPORTING ATPASE SARCOPLASMIC/ENDOPLASMIC RETICULUM TYPE
signature sequence match: PANTHER PTHR42861:SF102 match 1

PF13246
type: Resource
database: Pfam
comment: Cation_ATPase
signature sequence match: Pfam PF13246 match 1

PF00689
type: Resource
database: Pfam
comment: Cation_ATPase_C
signature sequence match: Pfam PF00689 match 1

PF00690
type: Resource
database: Pfam
comment: Cation_ATPase_N
signature sequence match: Pfam PF00690 match 1

PF00122
type: Resource
database: Pfam
comment: E1-E2_ATPase
signature sequence match: Pfam PF00122 match 1

PF08282
type: Resource
database: Pfam
comment: Hydrolase_3
signature sequence match: Pfam PF08282 match 1

PR00119
type: Resource
database: PRINTS
comment: CATATPASE

SFLDG00002
type: Resource
database: SFLD
comment: C1.7:_P-type_atpase_like
signature sequence match: SFLD SFLDG00002 match 1

SFLDF00027
type: Resource
database: SFLD
comment: p-type_atpase
signature sequence match: SFLD SFLDF00027 match 1

SM00831
type: Resource
database: SMART
comment: Cation_ATPase_N
signature sequence match: SMART SM00831 match 1

SSF81653
type: Resource
database: SUPFAM
comment: Calcium ATPase, transduction domain A
signature sequence match: SUPFAM SSF81653 match 1

SSF81665
type: Resource
database: SUPFAM
comment: Calcium ATPase, transmembrane domain M
signature sequence match: SUPFAM SSF81665 match 1

SSF56784
type: Resource
database: SUPFAM
comment: HAD-like
signature sequence match: SUPFAM SSF56784 match 1

SSF81660
type: Resource
database: SUPFAM
comment: Metal cation-transporting ATPase, ATP-binding domain N
signature sequence match: SUPFAM SSF81660 match 1

TIGR01116
type: Resource
database: TIGRFAMs
comment: ATPase-IIA1_Ca
signature sequence match: TIGRFAMs TIGR01116 match 1

TIGR01494
type: Resource
database: TIGRFAMs
comment: ATPase_P-type
signature sequence match: TIGRFAMs TIGR01494 match 1
signature sequence match: TIGRFAMs TIGR01494 match 2

PS00154
type: Resource
database: PROSITE
comment: ATPASE_E1_E2
signature sequence match: PROSITE PS00154 match 1

SIPB163AB89F0DE76CB
type: Structured Name
full name: Probable calcium-transporting ATPase
ec name: 7.2.2.10

SIP7F7164377FD02F17
type: Structured Name
full name: Calcium pump

TBA1
type: Gene

SIP3FBA7404B0E494AE
type: Function Annotation
comment: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.

SIP64B156FBB1A03041
type: Subcellular Location Annotation
comment: May be located in the flagellar pocket of the membrane.
located in: SIP5699498EFEA17C1C
located in: SIPF221353ED877D82A

SIP29E1EA6B1A16F14B
type: Similarity Annotation
comment: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.

PRO_0000046228
type: Chain Annotation
comment: Probable calcium-transporting ATPase
mass: 110314
range: 22574301721998638tt1tt1011

22574301721998638tt1
type: Position
type: ExactPosition
position: 1
reference: P35315-1

22574301721998638tt1011
type: Position
type: ExactPosition
position: 1011
reference: P35315-1

SIPC775546DABF7F2D0
type: Topological Domain Annotation
comment: Cytoplasmic
range: 22574301721998638tt1tt65

22574301721998638tt65
type: Position
type: ExactPosition
position: 65
reference: P35315-1

SIP1DC29152165BAE72
type: Transmembrane Annotation
comment: Helical
range: 22574301721998638tt66tt84

22574301721998638tt66
type: Position
type: ExactPosition
position: 66
reference: P35315-1

22574301721998638tt84
type: Position
type: ExactPosition
position: 84
reference: P35315-1

SIP6111BB30DA5E389D
type: Topological Domain Annotation
comment: Extracellular
range: 22574301721998638tt85tt90

22574301721998638tt85
type: Position
type: ExactPosition
position: 85
reference: P35315-1

22574301721998638tt90
type: Position
type: ExactPosition
position: 90
reference: P35315-1

SIP855F7A145E64BEA5
type: Transmembrane Annotation
comment: Helical
range: 22574301721998638tt91tt110

22574301721998638tt91
type: Position
type: ExactPosition
position: 91
reference: P35315-1

22574301721998638tt110
type: Position
type: ExactPosition
position: 110
reference: P35315-1

SIPE4011070FD213BB8
type: Topological Domain Annotation
comment: Cytoplasmic
range: 22574301721998638tt111tt258

22574301721998638tt111
type: Position
type: ExactPosition
position: 111
reference: P35315-1

22574301721998638tt258
type: Position
type: ExactPosition
position: 258
reference: P35315-1

SIP59B2002325C06CBA
type: Transmembrane Annotation
comment: Helical
range: 22574301721998638tt259tt278

22574301721998638tt259
type: Position
type: ExactPosition
position: 259
reference: P35315-1

22574301721998638tt278
type: Position
type: ExactPosition
position: 278
reference: P35315-1

SIP2B0BB4E19AA9BA25
type: Topological Domain Annotation
comment: Extracellular
range: 22574301721998638tt279tt303

22574301721998638tt279
type: Position
type: ExactPosition
position: 279
reference: P35315-1

22574301721998638tt303
type: Position
type: ExactPosition
position: 303
reference: P35315-1

SIP6A2C4C59D1C6DF6B
type: Transmembrane Annotation
comment: Helical
range: 22574301721998638tt304tt321

22574301721998638tt304
type: Position
type: ExactPosition
position: 304
reference: P35315-1

22574301721998638tt321
type: Position
type: ExactPosition
position: 321
reference: P35315-1

SIPFBEA317044F53A2A
type: Topological Domain Annotation
comment: Cytoplasmic
range: 22574301721998638tt322tt770

22574301721998638tt322
type: Position
type: ExactPosition
position: 322
reference: P35315-1

22574301721998638tt770
type: Position
type: ExactPosition
position: 770
reference: P35315-1

SIP278981AB8FBED38C
type: Transmembrane Annotation
comment: Helical
range: 22574301721998638tt771tt794

22574301721998638tt771
type: Position
type: ExactPosition
position: 771
reference: P35315-1

22574301721998638tt794
type: Position
type: ExactPosition
position: 794
reference: P35315-1

SIP824AE22BE5E73964
type: Topological Domain Annotation
comment: Extracellular
range: 22574301721998638tt795tt835

22574301721998638tt795
type: Position
type: ExactPosition
position: 795
reference: P35315-1

22574301721998638tt835
type: Position
type: ExactPosition
position: 835
reference: P35315-1

SIP2DD28C4BAB4E66A9
type: Transmembrane Annotation
comment: Helical
range: 22574301721998638tt836tt856

22574301721998638tt836
type: Position
type: ExactPosition
position: 836
reference: P35315-1

22574301721998638tt856
type: Position
type: ExactPosition
position: 856
reference: P35315-1

SIP3B56203BA65DCAE3
type: Topological Domain Annotation
comment: Cytoplasmic
range: 22574301721998638tt857tt885

22574301721998638tt857
type: Position
type: ExactPosition
position: 857
reference: P35315-1

22574301721998638tt885
type: Position
type: ExactPosition
position: 885
reference: P35315-1

SIPE1274DF6F1194978
type: Transmembrane Annotation
comment: Helical
range: 22574301721998638tt886tt905

22574301721998638tt886
type: Position
type: ExactPosition
position: 886
reference: P35315-1

22574301721998638tt905
type: Position
type: ExactPosition
position: 905
reference: P35315-1

SIPD903EFE0814B58E2
type: Topological Domain Annotation
comment: Extracellular
range: 22574301721998638tt906tt922

22574301721998638tt906
type: Position
type: ExactPosition
position: 906
reference: P35315-1

22574301721998638tt922
type: Position
type: ExactPosition
position: 922
reference: P35315-1

SIPAD6E83C2FEB711F5
type: Transmembrane Annotation
comment: Helical
range: 22574301721998638tt923tt942

22574301721998638tt923
type: Position
type: ExactPosition
position: 923
reference: P35315-1

22574301721998638tt942
type: Position
type: ExactPosition
position: 942
reference: P35315-1

SIPAC25CF8DF84D360E
type: Topological Domain Annotation
comment: Cytoplasmic
range: 22574301721998638tt943tt1011

22574301721998638tt943
type: Position
type: ExactPosition
position: 943
reference: P35315-1

SIP636E7CBAA8BD639B
type: Active Site Annotation
comment: 4-aspartylphosphate intermediate
range: 22574301721998638tt357tt357

22574301721998638tt357
type: Position
type: ExactPosition
position: 357
reference: P35315-1

22574301721998638tt514
type: Position
type: ExactPosition
position: 514
reference: P35315-1

P35315-1
type: Simple Sequence
modified: 1994-02-01
version: 1
mass: 110314
value: MLPENLPTDPAAMTPAAVAAALRVDTKVGLSSNEVEERRQAFGINELPSEPPTPFWKLVLAQFEDTLVRILLLAATVSFAMAVVENNAADFVEPFIILLILILNATVGVWQENRAEGAIEALKSFVPKTAVVLRDGDIKTVNAEELVPGDVVEVAVGNRVPADMRVVELHSTTLRADQSILNGESVEAMKQIEAVKGRQERFPACMVYSGTAIVYGKALCVVVRTGASTEIGTIERDVREQEEVKTPLQVKLDEFGVLLSKVIGYICLVVFAVNLVRWYATHKPTKNETFFTRYIQPSVHCLKVAVALAVAAIPEGLPAVVTTCLALGTRRMAQHNALVRDLPSVETLGRCTVICSDKTGTLTTNMMSVLHAFTLKGDGSIKEYELKDSRFNIVSNSVTCEGRQVSSPLEQDGALTKLANIAVLCNDASLHHNAATVQVEKIGEATEAALLVMSEKFANIKGDSAVNAFRTLCEGKWKKNATLEFTRKRKSMSVHVTSTVTGSPASSTNNLFVKGAPEEVLRRSTHVMQDNGAVVQLSATHRKRIIEQLDKISGGANALRCIGFAFKPTKAVQHVRLNDPATFEDVESDLTFVGACGMLDPPREEVRDAIVKCRTAGIRVVVITGDRKETAEAICCKLGLLSSTADTTGLSYTGQELDAMTPAQKREAVLTAVLFSRTDPSHKMQLVQLLKDERLICAMTGDGVNDAPALKKADIGIAMGSGTEVAKSASKMVLADDNFATVVKAVQEGRAIYNNTKQFIRYLISSNIGEVVCILVTGLFGLPEALSPVQLLWVNLVTDGLPATALGFNAPDRDIMEQRPRRMEEPIVNGWLFMRYMVIGVYVGLATVGGFLWWFLRHGFSWHDLTTYTACSDMTNGTCLLLANPQTARAIALSILVVVEMLNALNALSENASLIVSRPSSNVWLLFAIFSSLSLHLIIMYVPFFAKLFNIVPLGVDPHVVQQAQPWSILTPTNFDDWKAVIVFSVPVIFLDELLKFITRRMEKAQEKKKD

http://purl.uniprot.org/uniprot/P35315#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/P35315#attribution-DC036A124EC8E88DF072B29F6D9BB9FE
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/P35315#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

P0DPG4
type: Protein
reviewed: true
created: 2018-05-23
modified: 2023-02-22
version: 10
mnemonic: ATP18_TRYBB
citation: http://purl.uniprot.org/citations/29440423
citation: http://purl.uniprot.org/citations/19436713
citation: http://purl.uniprot.org/citations/29247468
recommended name: SIPFCDA7F5375D7C33D
alternative name: SIP3A4BA61700407882
organism: http://purl.uniprot.org/taxonomy/5702
annotation: SIP5BBB139C60F54A91
annotation: SIPE496BC3E395E5266
annotation: SIP4B67D6AD48125765
annotation: SIP5FF246E2AD7B09F2
annotation: SIPDF9EEED36885B713
annotation: PRO_0000444146
annotation: SIP178E6AD70C2E281F
annotation: SIP9609173A13ECC0FC
annotation: SIP44606B2E5470A592
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/139
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/375
classified with: http://purl.uniprot.org/keywords/999
classified with: http://purl.uniprot.org/keywords/677
classified with: http://purl.uniprot.org/keywords/809
classified with: GO_0005743
classified with: GO_0045261
classified with: GO_0006754
classified with: GO_1902600
sequence: MMRRVYSPVFCSVAAARFAATSAAKKYDLFGYEVDTNTAPWIEKIKKCKYYDEAGEVLVNMNVSNCPPDIATYNATLQCIYQSPSKQSTPVDNESKFCAMMDLLEEMQHRNRLKPNEESWTWVMKECVKSGQFRLGYCIQQVMETECKGCPADLVKANEANAQKAKTEGKEHPGHLSQQAGLFDVKVE

P0DPG4-citation-29440423
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-188
scope: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 19-188
scope: FUNCTION
scope: SUBUNIT
scope: SUBCELLULAR LOCATION

427
type: Strain

P0DPG4-citation-19436713
type: Citation Statement
scope: FUNCTION
scope: SUBCELLULAR LOCATION
scope: SUBUNIT
scope: IDENTIFICATION BY MASS SPECTROMETRY
scope: NOMENCLATURE

P0DPG4-citation-29247468
type: Citation Statement
scope: FUNCTION
scope: DISRUPTION PHENOTYPE
scope: PROTEIN SEQUENCE OF 19-23
scope: SUBCELLULAR LOCATION
scope: TOPOLOGY
scope: SUBUNIT
scope: IDENTIFICATION BY MASS SPECTROMETRY

6F5D
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 3.20
chain sequence mapping: PDB 6F5D tt19tt188
chain sequence mapping: PDB 6F5D tt10tt75
chain sequence mapping: PDB 6F5D tt25tt584
chain sequence mapping: PDB 6F5D tt22tt519
chain sequence mapping: PDB 6F5D tt18tt182
chain sequence mapping: PDB 6F5D tt2tt305

PDB 6F5D tt19tt188
chain: J/K/L=19-188

8APA
type: Structure Resource
database: PDB
method: Electron Microscopy
resolution: 3.70
chain sequence mapping: PDB 8APA tt1tt188
chain sequence mapping: PDB 8APA tt1tt75
chain sequence mapping: PDB 8APA tt1tt229
chain sequence mapping: PDB 8APA tt1tt584
chain sequence mapping: PDB 8APA tt1tt519

PDB 8APA tt1tt188
chain: J1/K1/L1=1-188

8APB
type: Structure Resource
database: PDB
method: Electron Microscopy
resolution: 3.80
chain sequence mapping: PDB 8APB tt1tt188
chain sequence mapping: PDB 8APB tt1tt75
chain sequence mapping: PDB 8APB tt1tt229
chain sequence mapping: PDB 8APB tt1tt584
chain sequence mapping: PDB 8APB tt1tt519

PDB 8APB tt1tt188
chain: J1/K1/L1=1-188

8APC
type: Structure Resource
database: PDB
method: Electron Microscopy
resolution: 3.50
chain sequence mapping: PDB 8APC tt1tt188
chain sequence mapping: PDB 8APC tt1tt75
chain sequence mapping: PDB 8APC tt1tt229
chain sequence mapping: PDB 8APC tt1tt584
chain sequence mapping: PDB 8APC tt1tt519

PDB 8APC tt1tt188
chain: J1/K1/L1=1-188

8APD
type: Structure Resource
database: PDB
method: Electron Microscopy
resolution: 3.70
chain sequence mapping: PDB 8APD tt1tt188
chain sequence mapping: PDB 8APD tt1tt75
chain sequence mapping: PDB 8APD tt1tt229
chain sequence mapping: PDB 8APD tt1tt584
chain sequence mapping: PDB 8APD tt1tt519

PDB 8APD tt1tt188
chain: J1/K1/L1=1-188

8APE
type: Structure Resource
database: PDB
method: Electron Microscopy
resolution: 3.70
chain sequence mapping: PDB 8APE tt1tt188
chain sequence mapping: PDB 8APE tt1tt75
chain sequence mapping: PDB 8APE tt1tt229
chain sequence mapping: PDB 8APE tt1tt584
chain sequence mapping: PDB 8APE tt1tt519

PDB 8APE tt1tt188
chain: J1/K1/L1=1-188

8APF
type: Structure Resource
database: PDB
method: Electron Microscopy
resolution: 4.30
chain sequence mapping: PDB 8APF tt1tt188
chain sequence mapping: PDB 8APF tt1tt75
chain sequence mapping: PDB 8APF tt1tt229
chain sequence mapping: PDB 8APF tt1tt584
chain sequence mapping: PDB 8APF tt1tt519

PDB 8APF tt1tt188
chain: J1/K1/L1=1-188

8APG
type: Structure Resource
database: PDB
method: Electron Microscopy
resolution: 3.50
chain sequence mapping: PDB 8APG tt1tt188
chain sequence mapping: PDB 8APG tt1tt75
chain sequence mapping: PDB 8APG tt1tt229
chain sequence mapping: PDB 8APG tt1tt584
chain sequence mapping: PDB 8APG tt1tt519

PDB 8APG tt1tt188
chain: J1/K1/L1=1-188

8APH
type: Structure Resource
database: PDB
method: Electron Microscopy
resolution: 3.80
chain sequence mapping: PDB 8APH tt1tt188
chain sequence mapping: PDB 8APH tt1tt75
chain sequence mapping: PDB 8APH tt1tt229
chain sequence mapping: PDB 8APH tt1tt584
chain sequence mapping: PDB 8APH tt1tt519

PDB 8APH tt1tt188
chain: J1/K1/L1=1-188

8APJ
type: Structure Resource
database: PDB
method: Electron Microscopy
resolution: 3.80
chain sequence mapping: PDB 8APJ tt1tt188
chain sequence mapping: PDB 8APJ tt1tt75
chain sequence mapping: PDB 8APJ tt1tt229
chain sequence mapping: PDB 8APJ tt1tt584
chain sequence mapping: PDB 8APJ tt1tt519

PDB 8APJ tt1tt188
chain: J1/K1/L1=1-188

8APK
type: Structure Resource
database: PDB
method: Electron Microscopy
resolution: 3.70
chain sequence mapping: PDB 8APK tt1tt188
chain sequence mapping: PDB 8APK tt1tt75
chain sequence mapping: PDB 8APK tt1tt229
chain sequence mapping: PDB 8APK tt1tt584
chain sequence mapping: PDB 8APK tt1tt519

PDB 8APK tt1tt188
chain: J1/K1/L1=1-188

3.A.2.1.13
type: Resource
database: TCDB
comment: the h+- or na+-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

http://purl.uniprot.org/gene3d/1.25.40.10
type: Resource
database: Gene3D
comment: Tetratricopeptide repeat domain
signature sequence match: Gene3D 1.25.40.10 match 1
signature sequence match: Gene3D 1.25.40.10 match 2

IPR011990
type: Resource
database: InterPro
comment: TPR-like_helical_dom_sf

SIPFCDA7F5375D7C33D
type: Structured Name
full name: ATP synthase subunit p18, mitochondrial

SIP3A4BA61700407882
type: Structured Name
full name: ATP synthase F1 subunit p18

http://purl.uniprot.org/uniprot/P0DPG4#gene-MD58915108D9E0AEE27863DBD499E90426A
type: Gene
orf name: Tb427.05.1710

SIP5BBB139C60F54A91
type: Function Annotation
comment: Mitochondrial membrane ATP synthase (F(1)F(o) ATP synthase) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:19436713, PubMed:29247468). F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(o) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk (PubMed:19436713, PubMed:29247468, PubMed:29440423). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1) (PubMed:19436713, PubMed:29440423). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (Probable). Contrary to the procyclic, insect form that requires F(1)F(o) ATP synthase for ATP synthesis, the bloodstream form relies on ATP hydrolysis by F(1)F(o) ATP synthase to maintain its mitochondrial membrane potential (PubMed:29247468).

SIPE496BC3E395E5266
type: Subunit Annotation
comment: F-type ATPases have 2 components, F(1) - the catalytic core - and F(o) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1), plus the additional subunit P18 (Tb427.05.1710) that is not present in F(1)F(o) ATP synthase from metazoa (PubMed:19436713, PubMed:29247468, PubMed:29440423). Subunit P18 (Tb927.5.1710) interacts with the alpha subunit with a 1:1 stoichiometry; the interaction is direct (PubMed:29440423). Subunit gamma is part of the central stalk (PubMed:29440423). F(o) has three main subunits: a, b and c (PubMed:19436713). The trypanosomal ATPase complex contains additional subunits that are not present in the F(1)F(o) ATP synthase from metazoa (PubMed:19436713, PubMed:29247468, PubMed:29440423).

SIP5FF246E2AD7B09F2
type: Disruption Phenotype Annotation
comment: RNAi-mediated knockdown of the protein impairs assembly of the F(1) component and slows the proliferation rate of procyclic cells that are cultivated in vitro in the presence of glucose. RNAi-mediated knockdown of the protein also slows the proliferation rate of the bloodstream form of the parasite, despite the fact that the organism can profit from blood glucose as source of energy. Mitochondrial membrane potential is dramatically reduced in the bloodstream form that relies on ATP hydrolysis to maintain mitochondrial membrane potential.

SIPDF9EEED36885B713
type: Transit Peptide Annotation
comment: Mitochondrion
range: 22571068099605550tt1tt18

22571068099605550tt1
type: Position
type: ExactPosition
position: 1
reference: MMRRVYSPVFCSVAAARFAATSAAKKYDLFGYEVDTNTAPWIEKIKKCKYYDEAGEVLVNMNVSNCPPDIATYNATLQCIYQSPSKQSTPVDNESKFCAMMDLLEEMQHRNRLKPNEESWTWVMKECVKSGQFRLGYCIQQVMETECKGCPADLVKANEANAQKAKTEGKEHPGHLSQQAGLFDVKVE

22571068099605550tt18
type: Position
type: ExactPosition
position: 18
reference: MMRRVYSPVFCSVAAARFAATSAAKKYDLFGYEVDTNTAPWIEKIKKCKYYDEAGEVLVNMNVSNCPPDIATYNATLQCIYQSPSKQSTPVDNESKFCAMMDLLEEMQHRNRLKPNEESWTWVMKECVKSGQFRLGYCIQQVMETECKGCPADLVKANEANAQKAKTEGKEHPGHLSQQAGLFDVKVE

PRO_0000444146
type: Chain Annotation
comment: ATP synthase subunit p18, mitochondrial
mass: 19169
range: 22571068099605550tt19tt188

22571068099605550tt19
type: Position
type: ExactPosition
position: 19
reference: MMRRVYSPVFCSVAAARFAATSAAKKYDLFGYEVDTNTAPWIEKIKKCKYYDEAGEVLVNMNVSNCPPDIATYNATLQCIYQSPSKQSTPVDNESKFCAMMDLLEEMQHRNRLKPNEESWTWVMKECVKSGQFRLGYCIQQVMETECKGCPADLVKANEANAQKAKTEGKEHPGHLSQQAGLFDVKVE

22571068099605550tt188
type: Position
type: ExactPosition
position: 188
reference: MMRRVYSPVFCSVAAARFAATSAAKKYDLFGYEVDTNTAPWIEKIKKCKYYDEAGEVLVNMNVSNCPPDIATYNATLQCIYQSPSKQSTPVDNESKFCAMMDLLEEMQHRNRLKPNEESWTWVMKECVKSGQFRLGYCIQQVMETECKGCPADLVKANEANAQKAKTEGKEHPGHLSQQAGLFDVKVE

SIP178E6AD70C2E281F
type: Repeat Annotation
comment: PPR
range: 22571068099605550tt36tt70

22571068099605550tt36
type: Position
type: ExactPosition
position: 36
reference: MMRRVYSPVFCSVAAARFAATSAAKKYDLFGYEVDTNTAPWIEKIKKCKYYDEAGEVLVNMNVSNCPPDIATYNATLQCIYQSPSKQSTPVDNESKFCAMMDLLEEMQHRNRLKPNEESWTWVMKECVKSGQFRLGYCIQQVMETECKGCPADLVKANEANAQKAKTEGKEHPGHLSQQAGLFDVKVE

22571068099605550tt70
type: Position
type: ExactPosition
position: 70
reference: MMRRVYSPVFCSVAAARFAATSAAKKYDLFGYEVDTNTAPWIEKIKKCKYYDEAGEVLVNMNVSNCPPDIATYNATLQCIYQSPSKQSTPVDNESKFCAMMDLLEEMQHRNRLKPNEESWTWVMKECVKSGQFRLGYCIQQVMETECKGCPADLVKANEANAQKAKTEGKEHPGHLSQQAGLFDVKVE

SIP9609173A13ECC0FC
type: Repeat Annotation
comment: PPR
range: 22571068099605550tt75tt109

22571068099605550tt75
type: Position
type: ExactPosition
position: 75
reference: MMRRVYSPVFCSVAAARFAATSAAKKYDLFGYEVDTNTAPWIEKIKKCKYYDEAGEVLVNMNVSNCPPDIATYNATLQCIYQSPSKQSTPVDNESKFCAMMDLLEEMQHRNRLKPNEESWTWVMKECVKSGQFRLGYCIQQVMETECKGCPADLVKANEANAQKAKTEGKEHPGHLSQQAGLFDVKVE

22571068099605550tt109
type: Position
type: ExactPosition
position: 109
reference: MMRRVYSPVFCSVAAARFAATSAAKKYDLFGYEVDTNTAPWIEKIKKCKYYDEAGEVLVNMNVSNCPPDIATYNATLQCIYQSPSKQSTPVDNESKFCAMMDLLEEMQHRNRLKPNEESWTWVMKECVKSGQFRLGYCIQQVMETECKGCPADLVKANEANAQKAKTEGKEHPGHLSQQAGLFDVKVE

SIP44606B2E5470A592
type: Repeat Annotation
comment: PPR
range: 22571068099605550tt116tt146

22571068099605550tt116
type: Position
type: ExactPosition
position: 116
reference: MMRRVYSPVFCSVAAARFAATSAAKKYDLFGYEVDTNTAPWIEKIKKCKYYDEAGEVLVNMNVSNCPPDIATYNATLQCIYQSPSKQSTPVDNESKFCAMMDLLEEMQHRNRLKPNEESWTWVMKECVKSGQFRLGYCIQQVMETECKGCPADLVKANEANAQKAKTEGKEHPGHLSQQAGLFDVKVE

22571068099605550tt146
type: Position
type: ExactPosition
position: 146
reference: MMRRVYSPVFCSVAAARFAATSAAKKYDLFGYEVDTNTAPWIEKIKKCKYYDEAGEVLVNMNVSNCPPDIATYNATLQCIYQSPSKQSTPVDNESKFCAMMDLLEEMQHRNRLKPNEESWTWVMKECVKSGQFRLGYCIQQVMETECKGCPADLVKANEANAQKAKTEGKEHPGHLSQQAGLFDVKVE

MMRRVYSPVFCSVAAARFAATSAAKKYDLFGYEVDTNTAPWIEKIKKCKYYDEAGEVLVNMNVSNCPPDIATYNATLQCIYQSPSKQSTPVDNESKFCAMMDLLEEMQHRNRLKPNEESWTWVMKECVKSGQFRLGYCIQQVMETECKGCPADLVKANEANAQKAKTEGKEHPGHLSQQAGLFDVKVE
type: Simple Sequence
modified: 2018-05-23
version: 1
precursor: true
mass: 21242

http://purl.uniprot.org/uniprot/P0DPG4#attribution-50E613E4FC2EAC1CA226ABA7E64EA32F
manual: true
evidence: ECO_0000255
source: PRU00708

http://purl.uniprot.org/uniprot/P0DPG4#attribution-E3D6459752F4AD97E20E2B48F890D042
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/19436713

http://purl.uniprot.org/uniprot/P0DPG4#attribution-AE64254AA02626AD2D4839443424938C
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/29247468

http://purl.uniprot.org/uniprot/P0DPG4#attribution-A4198AF5F3020F15E0899ED25138CDBC
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/29440423

http://purl.uniprot.org/uniprot/P0DPG4#attribution-EC9C13C967678D168E3FF7EFDFE0C32F
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/19436713

http://purl.uniprot.org/uniprot/P0DPG4#attribution-483971347F4641FFD00833968F9D368A
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/29247468

http://purl.uniprot.org/uniprot/P0DPG4#attribution-5F77044BC10B6494AC06E0497E4CAACB
manual: true
evidence: ECO_0000305

http://purl.uniprot.org/uniprot/P0DPG4#attribution-1B472C41E3184782ED9999C10FF2E803
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/19436713

http://purl.uniprot.org/uniprot/P0DPG4#attribution-BC3BEB0173CC9E739DBF550186D8F5E5
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/29247468

http://purl.uniprot.org/uniprot/P0DPG4#attribution-CC93AA579CEF14279F72BB3C100026D2
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/29440423

P0DPG3
type: Protein
reviewed: true
created: 2018-05-23
modified: 2023-02-22
version: 15
mnemonic: ATP5E_TRYBB
replaces: A0A2U3T1N7
citation: http://purl.uniprot.org/citations/29440423
citation: http://purl.uniprot.org/citations/19436713
citation: http://purl.uniprot.org/citations/29247468
recommended name: SIP9709C9C6050756EB
alternative name: SIPCF88CA72DF7AE9A9
organism: http://purl.uniprot.org/taxonomy/5702
annotation: SIP07A8FAF6FFD316BA
annotation: SIP6C8BFAB0D4FA58AF
annotation: SIP14D9ECDBC05D3B4D
annotation: SIP28B9DA71ADF09013
annotation: SIP2774B97B940080D9
annotation: PRO_0000444145
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/139
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/375
classified with: http://purl.uniprot.org/keywords/999
classified with: http://purl.uniprot.org/keywords/809
classified with: GO_0000275
classified with: GO_0046933
sequence: MIRRSCALLSSSWRDHGISYLKYLNVCTETLHSTVKESRRAKYERWSKPCYTAQRPDGAGGQETIDKVPIHTKDY

P0DPG3-citation-29440423
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 10-75
scope: SUBUNIT
scope: SUBCELLULAR LOCATION
scope: FUNCTION

427
type: Strain

P0DPG3-citation-19436713
type: Citation Statement
scope: FUNCTION
scope: SUBCELLULAR LOCATION
scope: SUBUNIT
scope: IDENTIFICATION BY MASS SPECTROMETRY
scope: NOMENCLATURE

P0DPG3-citation-29247468
type: Citation Statement
scope: FUNCTION
scope: PROTEIN SEQUENCE OF 10-15
scope: SUBCELLULAR LOCATION
scope: SUBUNIT
scope: IDENTIFICATION BY MASS SPECTROMETRY

PDB 6F5D tt10tt75
chain: I=10-75

8AP9
type: Structure Resource
database: PDB
method: Electron Microscopy
resolution: 3.70
chain sequence mapping: PDB 8AP9 tt1tt75

PDB 8AP9 tt1tt75
chain: I=1-75

PDB 8APA tt1tt75
chain: I1=1-75

PDB 8APB tt1tt75
chain: I1=1-75

PDB 8APC tt1tt75
chain: I1=1-75

PDB 8APD tt1tt75
chain: I1=1-75

PDB 8APE tt1tt75
chain: I1=1-75

PDB 8APF tt1tt75
chain: I1=1-75

PDB 8APG tt1tt75
chain: I1=1-75

PDB 8APH tt1tt75
chain: I1=1-75

PDB 8APJ tt1tt75
chain: I1=1-75

PDB 8APK tt1tt75
chain: I1=1-75

cd12153
type: Resource
database: CDD
comment: F1-ATPase_epsilon
signature sequence match: CDD cd12153 match 1

http://purl.uniprot.org/gene3d/1.10.1620.20
type: Resource
database: Gene3D
comment: ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial
signature sequence match: Gene3D 1.10.1620.20 match 1

IPR006721
type: Resource
database: InterPro
comment: ATP_synth_F1_esu_mt

IPR036742
type: Resource
database: InterPro
comment: ATP_synth_F1_esu_sf_mt

PF04627
type: Resource
database: Pfam
comment: ATP-synt_Eps
signature sequence match: Pfam PF04627 match 1

SSF48690
type: Resource
database: SUPFAM
comment: Epsilon subunit of mitochondrial F1F0-ATP synthase
signature sequence match: SUPFAM SSF48690 match 1

SIP9709C9C6050756EB
type: Structured Name
full name: ATP synthase subunit epsilon, mitochondrial

SIPCF88CA72DF7AE9A9
type: Structured Name
full name: ATP synthase F1 subunit epsilon

http://purl.uniprot.org/uniprot/P0DPG3#gene-MD5D08CF7884CEDAB04EF36A4C5BD470A5A
type: Gene
orf name: Tb427.10.5050

SIP07A8FAF6FFD316BA
type: Function Annotation
comment: Mitochondrial membrane ATP synthase (F(1)F(o) ATP synthase) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:19436713, PubMed:29247468). F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(o) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk (PubMed:19436713, PubMed:29247468, PubMed:29440423). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1) (PubMed:19436713, PubMed:29440423). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (Probable). Contrary to the procyclic, insect form that requires F(1)F(o) ATP synthase for ATP synthesis, the bloodstream form relies on ATP hydrolysis by F(1)F(o) ATP synthase to maintain its mitochondrial membrane potential (PubMed:29247468).

SIP6C8BFAB0D4FA58AF
type: Subunit Annotation
comment: F-type ATPases have 2 components, F(1) - the catalytic core - and F(o) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1), plus the additional subunit P18 (Tb427.05.1710) that is not present in F(1)F(o) ATP synthase from metazoa (PubMed:19436713, PubMed:29247468, PubMed:29440423). Subunit P18 (Tb927.5.1710) interacts with the alpha subunit with a 1:1 stoichiometry; the interaction is direct (PubMed:29440423). Subunit gamma is part of the central stalk (PubMed:29440423). F(o) has three main subunits: a, b and c (PubMed:19436713). The trypanosomal ATPase complex contains additional subunits that are not present in the F(1)F(o) ATP synthase from metazoa (PubMed:19436713, PubMed:29247468, PubMed:29440423).

SIP28B9DA71ADF09013
type: Similarity Annotation
comment: Belongs to the eukaryotic ATPase epsilon family.

SIP2774B97B940080D9
type: Transit Peptide Annotation
comment: Mitochondrion
range: 22571068099605294tt1tt9

22571068099605294tt1
type: Position
type: ExactPosition
position: 1
reference: MIRRSCALLSSSWRDHGISYLKYLNVCTETLHSTVKESRRAKYERWSKPCYTAQRPDGAGGQETIDKVPIHTKDY

22571068099605294tt9
type: Position
type: ExactPosition
position: 9
reference: MIRRSCALLSSSWRDHGISYLKYLNVCTETLHSTVKESRRAKYERWSKPCYTAQRPDGAGGQETIDKVPIHTKDY

PRO_0000444145
type: Chain Annotation
comment: ATP synthase subunit epsilon, mitochondrial
mass: 7647
range: 22571068099605294tt10tt75

22571068099605294tt10
type: Position
type: ExactPosition
position: 10
reference: MIRRSCALLSSSWRDHGISYLKYLNVCTETLHSTVKESRRAKYERWSKPCYTAQRPDGAGGQETIDKVPIHTKDY

22571068099605294tt75
type: Position
type: ExactPosition
position: 75
reference: MIRRSCALLSSSWRDHGISYLKYLNVCTETLHSTVKESRRAKYERWSKPCYTAQRPDGAGGQETIDKVPIHTKDY

MIRRSCALLSSSWRDHGISYLKYLNVCTETLHSTVKESRRAKYERWSKPCYTAQRPDGAGGQETIDKVPIHTKDY
type: Simple Sequence
modified: 2018-05-23
version: 1
precursor: true
mass: 8691

http://purl.uniprot.org/uniprot/P0DPG3#attribution-E3D6459752F4AD97E20E2B48F890D042
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/19436713

http://purl.uniprot.org/uniprot/P0DPG3#attribution-AE64254AA02626AD2D4839443424938C
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/29247468

http://purl.uniprot.org/uniprot/P0DPG3#attribution-A4198AF5F3020F15E0899ED25138CDBC
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/29440423

http://purl.uniprot.org/uniprot/P0DPG3#attribution-EC9C13C967678D168E3FF7EFDFE0C32F
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/19436713

http://purl.uniprot.org/uniprot/P0DPG3#attribution-5F77044BC10B6494AC06E0497E4CAACB
manual: true
evidence: ECO_0000305

http://purl.uniprot.org/uniprot/P0DPG3#attribution-1B472C41E3184782ED9999C10FF2E803
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/19436713

http://purl.uniprot.org/uniprot/P0DPG3#attribution-BC3BEB0173CC9E739DBF550186D8F5E5
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/29247468

http://purl.uniprot.org/uniprot/P0DPG3#attribution-CC93AA579CEF14279F72BB3C100026D2
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/29440423

P22067
type: Protein
reviewed: true
created: 1991-08-01
modified: 2023-02-22
version: 94
mnemonic: ATP6_NAEFO
replaces: Q9MD39
citation: SIP9677610EE7D5C679
citation: http://purl.uniprot.org/citations/2007628
recommended name: SIP01806B802B154B42
alternative name: SIP6A0BCD129F2F9EAD
organism: http://purl.uniprot.org/taxonomy/5763
encoded in: Mitochondrion
annotation: SIP3520FA3711E8E985
annotation: SIP46CB95737C1B3B4D
annotation: SIP2F4DB8A40A9AC338
annotation: SIPCA75C595F4D25A94
annotation: PRO_0000082142
annotation: SIP1E89723BD6C4860F
annotation: SIP80C38B35B90EF891
annotation: SIP4A3C173345D2820C
annotation: SIP499D841F8AA876ED
annotation: SIP6090CD223B54EA9D
annotation: SIPC5E0DDC338CF626B
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/66
classified with: http://purl.uniprot.org/keywords/138
classified with: http://purl.uniprot.org/keywords/999
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0005743
classified with: GO_0045263
classified with: GO_0015078
classified with: GO_0015986
sequence: SFFYSLFKGTYNFIYVTIYSYLVDRTKMFFPFFFYLFLFICLSNLVGIVPFSFTITSHLNITFSLSFLVWWATCLLGFYESGLAFIAIFYVKGIPFVLVPFWALIEVISFIFRSVGLSLR

SIP9677610EE7D5C679
type: Submission Citation
author: McLaughlin G.L.
author: Vodkin M.H.
author: Huizinga H.W.
date: 2000-03
submitted to: EMBL/GenBank/DDBJ

P22067-citation-SIP9677610EE7D5C679
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: SEQUENCE REVISION

P22067-citation-2007628
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-119

ATCC 30894 / Lee
type: Strain

cd00310
type: Resource
database: CDD
comment: ATP-synt_Fo_a_6
signature sequence match: CDD cd00310 match 1

http://purl.uniprot.org/gene3d/1.20.120.220
type: Resource
database: Gene3D
comment: ATP synthase, F0 complex, subunit A
signature sequence match: Gene3D 1.20.120.220 match 1

IPR000568
type: Resource
database: InterPro
comment: ATP_synth_F0_asu

IPR045083
type: Resource
database: InterPro
comment: ATP_synth_F0_asu_bact/mt

IPR035908
type: Resource
database: InterPro
comment: F0_ATP_A_sf

PTHR11410
type: Resource
database: PANTHER
comment: ATP SYNTHASE SUBUNIT A
signature sequence match: PANTHER PTHR11410 match 1

PTHR11410:SF0
type: Resource
database: PANTHER
comment: ATP SYNTHASE SUBUNIT A
signature sequence match: PANTHER PTHR11410:SF0 match 1

PF00119
type: Resource
database: Pfam
comment: ATP-synt_A
signature sequence match: Pfam PF00119 match 1

PR00123
type: Resource
database: PRINTS
comment: ATPASEA

SSF81336
type: Resource
database: SUPFAM
comment: F1F0 ATP synthase subunit A
signature sequence match: SUPFAM SSF81336 match 1

SIP01806B802B154B42
type: Structured Name
full name: ATP synthase subunit a

SIP6A0BCD129F2F9EAD
type: Structured Name
full name: F-ATPase protein 6

ATP6
type: Gene
alternative label: OLI2

SIP3520FA3711E8E985
type: Function Annotation
comment: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.

SIP46CB95737C1B3B4D
type: Subunit Annotation
comment: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.

SIPCA75C595F4D25A94
type: Similarity Annotation
comment: Belongs to the ATPase A chain family.

PRO_0000082142
type: Chain Annotation
comment: ATP synthase subunit a
mass: 14091
range: 22573189275465518tf1tf120

22573189275465518tt1
type: Position
type: ExactPosition
position: 1
reference: SFFYSLFKGTYNFIYVTIYSYLVDRTKMFFPFFFYLFLFICLSNLVGIVPFSFTITSHLNITFSLSFLVWWATCLLGFYESGLAFIAIFYVKGIPFVLVPFWALIEVISFIFRSVGLSLR

22573189275465518tt120
type: Position
type: ExactPosition
position: 120
reference: SFFYSLFKGTYNFIYVTIYSYLVDRTKMFFPFFFYLFLFICLSNLVGIVPFSFTITSHLNITFSLSFLVWWATCLLGFYESGLAFIAIFYVKGIPFVLVPFWALIEVISFIFRSVGLSLR

SIP1E89723BD6C4860F
type: Transmembrane Annotation
comment: Helical
range: 22573189275465518tt2tt22

22573189275465518tt2
type: Position
type: ExactPosition
position: 2
reference: SFFYSLFKGTYNFIYVTIYSYLVDRTKMFFPFFFYLFLFICLSNLVGIVPFSFTITSHLNITFSLSFLVWWATCLLGFYESGLAFIAIFYVKGIPFVLVPFWALIEVISFIFRSVGLSLR

22573189275465518tt22
type: Position
type: ExactPosition
position: 22
reference: SFFYSLFKGTYNFIYVTIYSYLVDRTKMFFPFFFYLFLFICLSNLVGIVPFSFTITSHLNITFSLSFLVWWATCLLGFYESGLAFIAIFYVKGIPFVLVPFWALIEVISFIFRSVGLSLR

SIP80C38B35B90EF891
type: Transmembrane Annotation
comment: Helical
range: 22573189275465518tt29tt49

22573189275465518tt29
type: Position
type: ExactPosition
position: 29
reference: SFFYSLFKGTYNFIYVTIYSYLVDRTKMFFPFFFYLFLFICLSNLVGIVPFSFTITSHLNITFSLSFLVWWATCLLGFYESGLAFIAIFYVKGIPFVLVPFWALIEVISFIFRSVGLSLR

22573189275465518tt49
type: Position
type: ExactPosition
position: 49
reference: SFFYSLFKGTYNFIYVTIYSYLVDRTKMFFPFFFYLFLFICLSNLVGIVPFSFTITSHLNITFSLSFLVWWATCLLGFYESGLAFIAIFYVKGIPFVLVPFWALIEVISFIFRSVGLSLR

SIP4A3C173345D2820C
type: Transmembrane Annotation
comment: Helical
range: 22573189275465518tt59tt79

22573189275465518tt59
type: Position
type: ExactPosition
position: 59
reference: SFFYSLFKGTYNFIYVTIYSYLVDRTKMFFPFFFYLFLFICLSNLVGIVPFSFTITSHLNITFSLSFLVWWATCLLGFYESGLAFIAIFYVKGIPFVLVPFWALIEVISFIFRSVGLSLR

22573189275465518tt79
type: Position
type: ExactPosition
position: 79
reference: SFFYSLFKGTYNFIYVTIYSYLVDRTKMFFPFFFYLFLFICLSNLVGIVPFSFTITSHLNITFSLSFLVWWATCLLGFYESGLAFIAIFYVKGIPFVLVPFWALIEVISFIFRSVGLSLR

SIP499D841F8AA876ED
type: Transmembrane Annotation
comment: Helical
range: 22573189275465518tt94tt116

22573189275465518tt94
type: Position
type: ExactPosition
position: 94
reference: SFFYSLFKGTYNFIYVTIYSYLVDRTKMFFPFFFYLFLFICLSNLVGIVPFSFTITSHLNITFSLSFLVWWATCLLGFYESGLAFIAIFYVKGIPFVLVPFWALIEVISFIFRSVGLSLR

22573189275465518tt116
type: Position
type: ExactPosition
position: 116
reference: SFFYSLFKGTYNFIYVTIYSYLVDRTKMFFPFFFYLFLFICLSNLVGIVPFSFTITSHLNITFSLSFLVWWATCLLGFYESGLAFIAIFYVKGIPFVLVPFWALIEVISFIFRSVGLSLR

SFFYSLFKGTYNFIYVTIYSYLVDRTKMFFPFFFYLFLFICLSNLVGIVPFSFTITSHLNITFSLSFLVWWATCLLGFYESGLAFIAIFYVKGIPFVLVPFWALIEVISFIFRSVGLSLR
type: Simple Sequence
modified: 2008-04-08
version: 2
fragment: single
mass: 14091

http://purl.uniprot.org/uniprot/P22067#attribution-DC036A124EC8E88DF072B29F6D9BB9FE
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/P22067#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

P24499
type: Protein
reviewed: true
created: 1992-03-01
modified: 2023-02-22
version: 77
mnemonic: ATP6_TRYBB
old mnemonic: ATP6_TRYBR
citation: http://purl.uniprot.org/citations/2140530
recommended name: SIP01806B802B154B42
alternative name: SIP6A0BCD129F2F9EAD
organism: http://purl.uniprot.org/taxonomy/5702
encoded in: Mitochondrion
annotation: SIPF6837BAA242D55F1
annotation: SIP430173A131BCDFF7
annotation: SIP52D0186CAF09907F
annotation: SIP98DD8B23D7076EFF
annotation: PRO_0000082181
annotation: SIP24A06B4283238B3C
annotation: SIP6CC0FCA9D62E69B1
annotation: SIP023E2BFA87F0AA68
annotation: SIPC39823CD94C3B2BF
annotation: SIP49C58F11BA201732
annotation: SIP3F6EB2E9F2C61E62
annotation: SIPEA4029365324855B
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/66
classified with: http://purl.uniprot.org/keywords/138
classified with: http://purl.uniprot.org/keywords/999
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0005743
classified with: GO_0045263
classified with: GO_0006754
classified with: GO_1902600
sequence: P24499-1

P24499-citation-2140530
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA]

EMBL AAA97428.1
comment: Sequence problems.

8AP7
type: Structure Resource
database: PDB
method: Electron Microscopy
resolution: 2.70
chain sequence mapping: PDB 8AP7 tt1tt229

PDB 8AP7 tt1tt229
chain: A/a=1-229

PDB 8APA tt1tt229
chain: a=1-229

PDB 8APB tt1tt229
chain: a=1-229

PDB 8APC tt1tt229
chain: a=1-229

PDB 8APD tt1tt229
chain: a=1-229

PDB 8APE tt1tt229
chain: a=1-229

PDB 8APF tt1tt229
chain: a=1-229

PDB 8APG tt1tt229
chain: a=1-229

PDB 8APH tt1tt229
chain: a=1-229

PDB 8APJ tt1tt229
chain: a=1-229

PDB 8APK tt1tt229
chain: a=1-229

SIP01806B802B154B42
type: Structured Name
full name: ATP synthase subunit a

SIP6A0BCD129F2F9EAD
type: Structured Name
full name: F-ATPase protein 6

ATP6
type: Gene
alternative label: MURF4

SIPF6837BAA242D55F1
type: Function Annotation
comment: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.

SIP430173A131BCDFF7
type: Subunit Annotation
comment: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.

SIP98DD8B23D7076EFF
type: Similarity Annotation
comment: Belongs to the ATPase A chain family.

PRO_0000082181
type: Chain Annotation
comment: ATP synthase subunit a
mass: 28330
range: 22573197932706094tt1tt229

22573197932706094tt1
type: Position
type: ExactPosition
position: 1
reference: P24499-1

22573197932706094tt229
type: Position
type: ExactPosition
position: 229
reference: P24499-1

SIP24A06B4283238B3C
type: Transmembrane Annotation
comment: Helical
range: 22573197932706094tt24tt44

22573197932706094tt24
type: Position
type: ExactPosition
position: 24
reference: P24499-1

22573197932706094tt44
type: Position
type: ExactPosition
position: 44
reference: P24499-1

SIP6CC0FCA9D62E69B1
type: Transmembrane Annotation
comment: Helical
range: 22573197932706094tt45tt65

22573197932706094tt45
type: Position
type: ExactPosition
position: 45
reference: P24499-1

22573197932706094tt65
type: Position
type: ExactPosition
position: 65
reference: P24499-1

SIP023E2BFA87F0AA68
type: Transmembrane Annotation
comment: Helical
range: 22573197932706094tt83tt103

22573197932706094tt83
type: Position
type: ExactPosition
position: 83
reference: P24499-1

22573197932706094tt103
type: Position
type: ExactPosition
position: 103
reference: P24499-1

SIPC39823CD94C3B2BF
type: Transmembrane Annotation
comment: Helical
range: 22573197932706094tt117tt137

22573197932706094tt117
type: Position
type: ExactPosition
position: 117
reference: P24499-1

22573197932706094tt137
type: Position
type: ExactPosition
position: 137
reference: P24499-1

SIP49C58F11BA201732
type: Transmembrane Annotation
comment: Helical
range: 22573197932706094tt143tt163

22573197932706094tt143
type: Position
type: ExactPosition
position: 143
reference: P24499-1

22573197932706094tt163
type: Position
type: ExactPosition
position: 163
reference: P24499-1

SIP3F6EB2E9F2C61E62
type: Transmembrane Annotation
comment: Helical
range: 22573197932706094tt177tt199

22573197932706094tt177
type: Position
type: ExactPosition
position: 177
reference: P24499-1

22573197932706094tt199
type: Position
type: ExactPosition
position: 199
reference: P24499-1

SIPEA4029365324855B
type: Transmembrane Annotation
comment: Helical
range: 22573197932706094tt206tt228

22573197932706094tt206
type: Position
type: ExactPosition
position: 206
reference: P24499-1

22573197932706094tt228
type: Position
type: ExactPosition
position: 228
reference: P24499-1

P24499-1
type: Simple Sequence
modified: 1992-03-01
version: 1
mass: 28330
value: MFLFFFCDLFWLRLLLCMYYCVSRLCFIVYFNCLMLIFDFLLFCLFDLYLFVGLCLFLLLWFMLFNLYSLILYYCITYLNLYLLFCIVFLLYIAFLFLFCFLCDFFLFNNLLVGDSFMDVFFIRFLLCFLECFSLLCRCLSTFLRLFCNLLSSHFLLLMFFDFFYFIFVFFFYGVFCYFILFIFVFCFCLLFYVFLYLLDLFAAILQLFIFCNMILQLIMDFLLFLLFV

http://purl.uniprot.org/uniprot/P24499#attribution-DC036A124EC8E88DF072B29F6D9BB9FE
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/P24499#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

P30392
type: Protein
reviewed: true
created: 1993-04-01
modified: 2023-05-03
version: 143
mnemonic: ATPA_EUGGR
citation: http://purl.uniprot.org/citations/8435857
citation: http://purl.uniprot.org/citations/8346031
recommended name: SIP842922A2A742604F
alternative name: SIP605D291825F99072
alternative name: SIPA3FE03A31043C3FE
enzyme: http://purl.uniprot.org/enzyme/7.1.2.2
organism: http://purl.uniprot.org/taxonomy/3039
encoded in: Chloroplast
annotation: SIP173055F4F291E348
annotation: SIP1511A301693827D6
annotation: SIP60FFD73CDACC0247
annotation: SIP9CFBC0723DBE1CB2
annotation: SIP158D85FEC0C7A51E
annotation: PRO_0000144375
annotation: SIP4CB088BA50F2AB9B
annotation: SIP3C7D9881E0AFA50B
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/139
classified with: http://purl.uniprot.org/keywords/150
classified with: http://purl.uniprot.org/keywords/375
classified with: http://purl.uniprot.org/keywords/472
classified with: http://purl.uniprot.org/keywords/793
classified with: http://purl.uniprot.org/keywords/1278
classified with: GO_0009535
classified with: GO_0045261
classified with: GO_0005524
classified with: GO_0046933
classified with: GO_0046961
sequence: P30392-1

P30392-citation-8435857
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

Z / UTEX 753
type: Strain

P30392-citation-8346031
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

S29801
type: Resource
database: PIR
comment: PWEGA

cd18113
type: Resource
database: CDD
comment: ATP-synt_F1_alpha_C
signature sequence match: CDD cd18113 match 1

cd18116
type: Resource
database: CDD
comment: ATP-synt_F1_alpha_N
signature sequence match: CDD cd18116 match 1

cd01132
type: Resource
database: CDD
comment: F1-ATPase_alpha_CD
signature sequence match: CDD cd01132 match 1

http://purl.uniprot.org/gene3d/1.20.150.20
type: Resource
database: Gene3D
comment: ATP synthase alpha/beta chain, C-terminal domain
signature sequence match: Gene3D 1.20.150.20 match 1

MF_01346
type: Resource
database: HAMAP
comment: ATP_synth_alpha_bact
signature sequence match: HAMAP MF 01346 match 1

IPR023366
type: Resource
database: InterPro
comment: ATP_synth_asu-like_sf

IPR000793
type: Resource
database: InterPro
comment: ATP_synth_asu_C

IPR038376
type: Resource
database: InterPro
comment: ATP_synth_asu_C_sf

IPR033732
type: Resource
database: InterPro
comment: ATP_synth_F1_a_nt-bd_dom

IPR005294
type: Resource
database: InterPro
comment: ATP_synth_F1_asu

IPR020003
type: Resource
database: InterPro
comment: ATPase_a/bsu_AS

IPR004100
type: Resource
database: InterPro
comment: ATPase_F1/V1/A1_a/bsu_N

IPR036121
type: Resource
database: InterPro
comment: ATPase_F1/V1/A1_a/bsu_N_sf

IPR000194
type: Resource
database: InterPro
comment: ATPase_F1/V1/A1_a/bsu_nucl-bd

PTHR48082
type: Resource
database: PANTHER
comment: ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL
signature sequence match: PANTHER PTHR48082 match 1

PTHR48082:SF2
type: Resource
database: PANTHER
comment: ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL
signature sequence match: PANTHER PTHR48082:SF2 match 1

PF00006
type: Resource
database: Pfam
comment: ATP-synt_ab
signature sequence match: Pfam PF00006 match 1

PF00306
type: Resource
database: Pfam
comment: ATP-synt_ab_C
signature sequence match: Pfam PF00306 match 1

PF02874
type: Resource
database: Pfam
comment: ATP-synt_ab_N
signature sequence match: Pfam PF02874 match 1

PIRSF039088
type: Resource
database: PIRSF
comment: F_ATPase_subunit_alpha
signature sequence match: PIRSF PIRSF039088 match 1

SSF47917
type: Resource
database: SUPFAM
comment: C-terminal domain of alpha and beta subunits of F1 ATP synthase
signature sequence match: SUPFAM SSF47917 match 1

SSF50615
type: Resource
database: SUPFAM
comment: N-terminal domain of alpha and beta subunits of F1 ATP synthase
signature sequence match: SUPFAM SSF50615 match 1

TIGR00962
type: Resource
database: TIGRFAMs
comment: atpA
signature sequence match: TIGRFAMs TIGR00962 match 1

PS00152
type: Resource
database: PROSITE
comment: ATPASE_ALPHA_BETA
signature sequence match: PROSITE PS00152 match 1

SIP842922A2A742604F
type: Structured Name
full name: ATP synthase subunit alpha, chloroplastic
ec name: 7.1.2.2

SIP605D291825F99072
type: Structured Name
full name: ATP synthase F1 sector subunit alpha

SIPA3FE03A31043C3FE
type: Structured Name
full name: F-ATPase subunit alpha

atpA
type: Gene

SIP173055F4F291E348
type: Function Annotation
comment: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

SIP60FFD73CDACC0247
type: Subunit Annotation
comment: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a, b, b' and c.

SIP158D85FEC0C7A51E
type: Similarity Annotation
comment: Belongs to the ATPase alpha/beta chains family.

PRO_0000144375
type: Chain Annotation
comment: ATP synthase subunit alpha, chloroplastic
mass: 55188
range: 22574280247685678tt1tt506

22574280247685678tt1
type: Position
type: ExactPosition
position: 1
reference: P30392-1

22574280247685678tt506
type: Position
type: ExactPosition
position: 506
reference: P30392-1

22574280247685678tt170
type: Position
type: ExactPosition
position: 170
reference: P30392-1

22574280247685678tt177
type: Position
type: ExactPosition
position: 177
reference: P30392-1

SIP3C7D9881E0AFA50B
type: Site Annotation
comment: Required for activity
range: 22574280247685678tt363tt363

22574280247685678tt363
type: Position
type: ExactPosition
position: 363
reference: P30392-1

P30392-1
type: Simple Sequence
modified: 1993-04-01
version: 1
mass: 55188
value: MIRVRPNEVTRIIRQQVKKYRQELKIVNVGTVLQVGDGIARIYGLEKVMAGELVEFDEGTIGIALNLEADNVGAVLMGEATNLKEGASVKTTGKIAQIPVGRGFLGRVVDALARPIDGKGDIASFTTRLIESPAPGIVSRRSVHEPLQTGLIAIDAMIPIGRGQRELIIGDRQTGKTAVATDTILNQKGQGVICVYVAIGQKASSVSQIVTTLEKRGAMEYTIIVAENADSSATLQYLAPYTGAALAEYFMYNGKHTLVIYDDLSKQAQAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDELGQGSMTALPIVETQAGDVSAYIPTNVISITDGQVFLSADIFNSGIRPAINVGISVSRVGSAAQIKAMKQVAGKLKLELAQFAELEAFSQFASDLDQATQNQLARGARLRELLKQPQASPLSVADQVATIYTGINGYLDDINLEDVRGFLIELREHINNEKPTFKEIINKTKTFTQEAELLLKFTIIDLKKNFKKRIK

http://purl.uniprot.org/uniprot/P30392#attribution-5C1C7D08C5C30A92BBCA3D89004F22BF
manual: true
evidence: ECO_0000255
source: MF_01346

Q9GS23
type: Protein
reviewed: true
created: 2018-05-23
modified: 2023-05-03
version: 112
mnemonic: ATPA_TRYBB
replaces: A0A2U3T1N3
citation: http://purl.uniprot.org/citations/11295183
citation: http://purl.uniprot.org/citations/29440423
citation: http://purl.uniprot.org/citations/19436713
citation: http://purl.uniprot.org/citations/29247468
conflicting sequence: SIP6EF2C0FEA2EA7E2B
recommended name: SIP6D9650F0ED154DFD
alternative name: SIP7ABB5CF6845A0892
organism: http://purl.uniprot.org/taxonomy/5702
annotation: SIP4AC8CB6727E28F38
annotation: SIP16C5D870B186037E
annotation: SIP3E50EA4DC4A8930E
annotation: SIP044B84D8F7F85B3F
annotation: SIPD0B2BA3BF60C6991
annotation: SIP55ADB9236BE0057E
annotation: PRO_5004326611
annotation: SIPB29C3709280DB082
annotation: SIP8BA634526C49DC19
annotation: SIPE063617FF612084C
annotation: SIPA1DF10F28D42E933
annotation: SIP76B5B4D77DD9E3FD
annotation: SIP8E966834C0D21F16
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/139
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/375
classified with: http://purl.uniprot.org/keywords/999
classified with: http://purl.uniprot.org/keywords/809
classified with: GO_0005743
classified with: GO_0045261
classified with: GO_0005524
classified with: GO_0046933
sequence: Q9GS23-1

Q9GS23-citation-11295183
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA]
scope: PROTEIN SEQUENCE OF 160-175
scope: SUBCELLULAR LOCATION
scope: SUBUNIT
scope: PROTEOLYTIC CLEAVAGE

Treu 667
type: Strain

Q9GS23-citation-29440423
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 25-584 IN COMPLEX WITH ADP
scope: FUNCTION
scope: SUBUNIT
scope: SUBCELLULAR LOCATION

427
type: Strain

Q9GS23-citation-19436713
type: Citation Statement
scope: FUNCTION
scope: SUBCELLULAR LOCATION
scope: SUBUNIT
scope: IDENTIFICATION BY MASS SPECTROMETRY
scope: DISRUPTION PHENOTYPE
scope: NOMENCLATURE

Q9GS23-citation-29247468
type: Citation Statement
scope: FUNCTION
scope: DISRUPTION PHENOTYPE
scope: PROTEIN SEQUENCE OF 25-29 AND 160-165
scope: SUBCELLULAR LOCATION
scope: SUBUNIT
scope: IDENTIFICATION BY MASS SPECTROMETRY
scope: PROTEOLYTIC CLEAVAGE

PDB 6F5D tt25tt584
chain: A/B/C=25-584

PDB 8APA tt1tt584
chain: A1/B1/C1=1-584

PDB 8APB tt1tt584
chain: A1/B1/C1=1-584

PDB 8APC tt1tt584
chain: A1/B1/C1=1-584

PDB 8APD tt1tt584
chain: A1/B1/C1=1-584

PDB 8APE tt1tt584
chain: A1/B1/C1=1-584

PDB 8APF tt1tt584
chain: A1/B1/C1=1-584

PDB 8APG tt1tt584
chain: A1/B1/C1=1-584

PDB 8APH tt1tt584
chain: A1/B1/C1=1-584

PDB 8APJ tt1tt584
chain: A1/B1/C1=1-584

PDB 8APK tt1tt584
chain: A1/B1/C1=1-584

SIP6D9650F0ED154DFD
type: Structured Name
full name: ATP synthase subunit alpha, mitochondrial

SIP7ABB5CF6845A0892
type: Structured Name
full name: ATP synthase F1 subunit alpha

http://purl.uniprot.org/uniprot/Q9GS23#gene-MD5CC04E0F7FE57E0D0A91ACED3C99CAF81
type: Gene
orf name: Tb427.07.7420
orf name: Tb427.07.7430

SIP4AC8CB6727E28F38
type: Function Annotation
comment: Mitochondrial membrane ATP synthase (F(1)F(o) ATP synthase) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:19436713, PubMed:29247468). F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(o) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk (PubMed:19436713, PubMed:29247468, PubMed:29440423). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1) (PubMed:19436713, PubMed:29440423). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (Probable). Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (PubMed:29440423). Contrary to the procyclic, insect form that requires F(1)F(o) ATP synthase for ATP synthesis, the bloodstream form relies on ATP hydrolysis by F(1)F(o) ATP synthase to maintain its mitochondrial membrane potential (PubMed:29247468).

SIP16C5D870B186037E
type: Subunit Annotation
comment: F-type ATPases have 2 components, F(1) - the catalytic core - and F(o) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1), plus the additional subunit P18 (Tb427.05.1710) that is not present in F(1)F(o) ATP synthase from metazoa (PubMed:19436713, PubMed:29247468, PubMed:29440423). Subunit P18 (Tb927.5.1710) interacts with the alpha subunit with a 1:1 stoichiometry; the interaction is direct (PubMed:29440423). Subunit gamma is part of the central stalk (PubMed:29440423). F(o) has three main subunits: a, b and c (PubMed:19436713). The trypanosomal ATPase complex contains additional subunits that are not present in the F(1)F(o) ATP synthase from metazoa (PubMed:19436713, PubMed:29247468, PubMed:29440423).

SIP044B84D8F7F85B3F
type: Disruption Phenotype Annotation
comment: RNAi-mediated knockdown of the protein in procyclic, insect stage cells impairs assembly of the F(1) component and slows the proliferation rate of procyclic cells that are cultivated in vitro, both in the presence and in the absence of glucose in the growth medium. ATP synthesis by oxidative phosphorylation is dramatically reduced in procyclic cells.

SIPD0B2BA3BF60C6991
type: Similarity Annotation
comment: Belongs to the ATPase alpha/beta chains family.

SIP55ADB9236BE0057E
type: Transit Peptide Annotation
comment: Mitochondrion
range: 22862451614823214tt1tt24

22862451614823214tt1
type: Position
type: ExactPosition
position: 1
reference: Q9GS23-1

22862451614823214tt24
type: Position
type: ExactPosition
position: 24
reference: Q9GS23-1

PRO_5004326611
type: Chain Annotation
comment: ATP synthase subunit alpha, mitochondrial
mass: 61020
range: 22862451614823214tt25tt584

22862451614823214tt25
type: Position
type: ExactPosition
position: 25
reference: Q9GS23-1

22862451614823214tt584
type: Position
type: ExactPosition
position: 584
reference: Q9GS23-1

22862451614823214tt207
type: Position
type: ExactPosition
position: 207
reference: Q9GS23-1

22862451614823214tt214
type: Position
type: ExactPosition
position: 214
reference: Q9GS23-1

22862451614823214tt464
type: Position
type: ExactPosition
position: 464
reference: Q9GS23-1

SIPE063617FF612084C
type: Site Annotation
comment: Cleavage
range: 22862451614823214tt159tt160

22862451614823214tt159
type: Position
type: ExactPosition
position: 159
reference: Q9GS23-1

22862451614823214tt160
type: Position
type: ExactPosition
position: 160
reference: Q9GS23-1

SIPA1DF10F28D42E933
type: Site Annotation
comment: Required for activity
range: 22862451614823214tt407tt407

22862451614823214tt407
type: Position
type: ExactPosition
position: 407
reference: Q9GS23-1

SIP76B5B4D77DD9E3FD
type: Sequence Conflict Annotation
conflicting sequence: SIP6EF2C0FEA2EA7E2B
substitution: CN
range: 22862451614823214tt205tt205

22862451614823214tt205
type: Position
type: ExactPosition
position: 205
reference: Q9GS23-1

SIP8E966834C0D21F16
type: Sequence Conflict Annotation
conflicting sequence: SIP6EF2C0FEA2EA7E2B
substitution: H
range: 22862451614823214tt466tt466

22862451614823214tt466
type: Position
type: ExactPosition
position: 466
reference: Q9GS23-1

Q9GS23-1
type: Simple Sequence
modified: 2018-07-18
version: 2
precursor: true
mass: 63503
value: MRRFGSKFASGLASRCALACPLASAATAPAGASTTSSTSSAQKSFFKTTEMIGYVHSIDGTIATLIPAPGNPGVAYNTIIQIQVSPTTFAAGLVFNLEKDGRIGIILMDNITEVQSGQKVMATGQLLHIPVGAGVLGKVVNPLGHEVPVGLVTRSRRLLDSTLGKVDTGAPNIVSRSPVNYNLLTGFKAVDTMIPIGRGQRELIVGDRQTGKTSIAVSTIINQVRINQQILSKNAVISIYVSIGQRCSNVARIHRLLQSYGALRYTTVMAATAAEPAGLQYLAPYAGVTMGEYFMNRGRHCLCVYDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLERAAMLSPGKGGGSVTALPIVETLSNDVTAYIVTNVISITDGQIYLDTKLFTGGQRPAVNIGLSVSRVGSSAQNAAMKGVAGKLKGILAEYRKLAADSVGGQQVQTIPMIRGARFVALFNQKQPSYFMNAIVSLYACLNGYLDDVKVQYVKFYEYLLVHRDLGIMYGTAKNKFFYMYVQELNYLIRFFTLNSPILHGELEEMLKQHTHLFLQHYQSKMNAIKSEKDVKALKNLLYSCKRAV

http://purl.uniprot.org/uniprot/Q9GS23#attribution-7AFD4628AD5A803E9E53DA34D6A91FB2
manual: true
evidence: ECO_0000255
source: PRU10106

http://purl.uniprot.org/uniprot/Q9GS23#attribution-C992D3F26888652198C0BA8096E05CFF
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/11295183

http://purl.uniprot.org/uniprot/Q9GS23#attribution-E3D6459752F4AD97E20E2B48F890D042
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/19436713

http://purl.uniprot.org/uniprot/Q9GS23#attribution-75121C5B1B2A5BC91E219E69630BBBDA
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/29247468

http://purl.uniprot.org/uniprot/Q9GS23#attribution-A4198AF5F3020F15E0899ED25138CDBC
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/29440423

http://purl.uniprot.org/uniprot/Q9GS23#attribution-6EA77757B665DF9359F0A949F1BE04B4
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/11295183

http://purl.uniprot.org/uniprot/Q9GS23#attribution-EC9C13C967678D168E3FF7EFDFE0C32F
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/19436713

http://purl.uniprot.org/uniprot/Q9GS23#attribution-5F77044BC10B6494AC06E0497E4CAACB
manual: true
evidence: ECO_0000305

http://purl.uniprot.org/uniprot/Q9GS23#attribution-1B472C41E3184782ED9999C10FF2E803
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/19436713

http://purl.uniprot.org/uniprot/Q9GS23#attribution-BC3BEB0173CC9E739DBF550186D8F5E5
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/29247468

http://purl.uniprot.org/uniprot/Q9GS23#attribution-CC93AA579CEF14279F72BB3C100026D2
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/29440423

http://purl.uniprot.org/uniprot/Q9GS23#attribution-778393F0A5A000CBE6B8C621D06AD9F1
manual: true
evidence: ECO_0000312
source: AAG23339.1

http://purl.uniprot.org/uniprot/Q9GS23#attribution-4D30C5CB917E8BE258A01D74EC69A1A6
manual: true
evidence: ECO_0007744
source: 6F5D

P31476
type: Protein
reviewed: true
created: 1993-07-01
modified: 2023-05-03
version: 134
mnemonic: ATPB_EUGGR
citation: http://purl.uniprot.org/citations/7923415
citation: http://purl.uniprot.org/citations/8346031
recommended name: SIP002B48693ECBD981
alternative name: SIP54BDE05048B44533
alternative name: SIPE5DC476874342920
enzyme: http://purl.uniprot.org/enzyme/7.1.2.2
organism: http://purl.uniprot.org/taxonomy/3039
encoded in: Chloroplast
annotation: SIPE550087AA5D8E340
annotation: SIP2017D50D1C9FD212
annotation: SIP6A8EC44BDBA3F5B3
annotation: SIPFF17A4E689CD3C1E
annotation: SIP21A6B7DF1D069A12
annotation: PRO_0000144513
annotation: SIP112638B79C0FE28F
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/139
classified with: http://purl.uniprot.org/keywords/150
classified with: http://purl.uniprot.org/keywords/375
classified with: http://purl.uniprot.org/keywords/472
classified with: http://purl.uniprot.org/keywords/793
classified with: http://purl.uniprot.org/keywords/1278
classified with: GO_0009535
classified with: GO_0045261
classified with: GO_0005524
classified with: GO_0046933
classified with: GO_0046961
sequence: P31476-1

P31476-citation-7923415
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

Z / UTEX 753
type: Strain

P31476-citation-8346031
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

S34914
type: Resource
database: PIR
comment: S34547

cd18110
type: Resource
database: CDD
comment: ATP-synt_F1_beta_C
signature sequence match: CDD cd18110 match 1

cd18115
type: Resource
database: CDD
comment: ATP-synt_F1_beta_N
signature sequence match: CDD cd18115 match 1

cd01133
type: Resource
database: CDD
comment: F1-ATPase_beta_CD
signature sequence match: CDD cd01133 match 1

MF_01347
type: Resource
database: HAMAP
comment: ATP_synth_beta_bact
signature sequence match: HAMAP MF 01347 match 1

IPR003593
type: Resource
database: InterPro
comment: AAA+_ATPase

IPR005722
type: Resource
database: InterPro
comment: ATP_synth_F1_bsu

IPR024034
type: Resource
database: InterPro
comment: ATPase_F1/V1_b/a_C

PTHR15184
type: Resource
database: PANTHER
comment: ATP SYNTHASE
signature sequence match: PANTHER PTHR15184 match 1

PTHR15184:SF71
type: Resource
database: PANTHER
comment: ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL
signature sequence match: PANTHER PTHR15184:SF71 match 1

SM00382
type: Resource
database: SMART
comment: AAA
signature sequence match: SMART SM00382 match 1
signature sequence match: SMART SM00382 match 2

TIGR01039
type: Resource
database: TIGRFAMs
comment: atpD
signature sequence match: TIGRFAMs TIGR01039 match 1

SIP002B48693ECBD981
type: Structured Name
full name: ATP synthase subunit beta, chloroplastic
ec name: 7.1.2.2

SIP54BDE05048B44533
type: Structured Name
full name: ATP synthase F1 sector subunit beta

SIPE5DC476874342920
type: Structured Name
full name: F-ATPase subunit beta

atpB
type: Gene

SIPE550087AA5D8E340
type: Function Annotation
comment: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

SIP6A8EC44BDBA3F5B3
type: Subunit Annotation
comment: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).

SIP21A6B7DF1D069A12
type: Similarity Annotation
comment: Belongs to the ATPase alpha/beta chains family.

PRO_0000144513
type: Chain Annotation
comment: ATP synthase subunit beta, chloroplastic
mass: 52078
range: 22574284559300142tt1tt480

22574284559300142tt1
type: Position
type: ExactPosition
position: 1
reference: P31476-1

22574284559300142tt480
type: Position
type: ExactPosition
position: 480
reference: P31476-1

22574284559300142tt161
type: Position
type: ExactPosition
position: 161
reference: P31476-1

22574284559300142tt168
type: Position
type: ExactPosition
position: 168
reference: P31476-1

P31476-1
type: Simple Sequence
modified: 1993-07-01
version: 1
mass: 52078
value: MKSSLRLNTGIILQIIGPVMDISFPSGKMPNIYNSLLIEGKTESGDRLKVVCEVQQLLGDNVVRAIAMSATDGLQRGIKVIDTGAPLSVPVGVTTLGRIFNVLGESVDKMGLIDYSITLPIHRAAPSFVELDTQLSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYQEMKESGVINDRNFKESKVALIYGQMNEPPGARMRVGLTALTMAEYFRDVNKQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLATEMGGLQERITSTKVGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRNLASKGIYPAVDPLDSTSTMLQPWIVGEEHYNTAQSVKKTLQRYKELQDIIAILGLDELSEEDRLVVSRARKVERFLSQPFFVAEVFTGSPGKYVTLAETIEGFKAILSGDLDEVPEQAFYLVGNIEEVISKAIELQ

http://purl.uniprot.org/uniprot/P31476#attribution-43A9882434E9506AAFC23F741E3F28D4
manual: true
evidence: ECO_0000255
source: MF_01347

Q9GPE9
type: Protein
reviewed: true
created: 2018-05-23
modified: 2023-05-03
version: 110
mnemonic: ATPB_TRYBB
replaces: A0A2U3T1M9
citation: http://purl.uniprot.org/citations/11295183
citation: http://purl.uniprot.org/citations/29440423
citation: http://purl.uniprot.org/citations/19436713
citation: http://purl.uniprot.org/citations/29247468
conflicting sequence: SIP2DA218A29F74DCF7
recommended name: SIPBD518F1EE7696080
alternative name: SIP4C78D3608BC760D9
enzyme: http://purl.uniprot.org/enzyme/7.1.2.2
organism: http://purl.uniprot.org/taxonomy/5702
annotation: SIP87374AC7F6AA5457
annotation: SIPB42AA1868E8B151D
annotation: SIP69792AEE8152ACE2
annotation: SIP1110175AC30ED0B3
annotation: SIP5032059D5DA9C7E4
annotation: SIPA09097ACDA198ACD
annotation: PRO_0000444142
annotation: SIP303EB4A9AA3CCBD9
annotation: SIP0B1AB2512056C322
annotation: SIP4D03C251DF120CEC
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/139
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/375
classified with: http://purl.uniprot.org/keywords/999
classified with: http://purl.uniprot.org/keywords/809
classified with: http://purl.uniprot.org/keywords/1278
classified with: GO_0005743
classified with: GO_0045261
classified with: GO_0005524
classified with: GO_0046933
classified with: GO_0046961
sequence: Q9GPE9-1

Q9GPE9-citation-11295183
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA]
scope: PROTEIN SEQUENCE OF 22-40
scope: SUBCELLULAR LOCATION
scope: SUBUNIT

Treu 667
type: Strain

Q9GPE9-citation-29440423
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 22-519 IN COMPLEX WITH ATP
scope: FUNCTION
scope: SUBUNIT
scope: SUBCELLULAR LOCATION

427
type: Strain

Q9GPE9-citation-19436713
type: Citation Statement
scope: FUNCTION
scope: SUBCELLULAR LOCATION
scope: SUBUNIT
scope: IDENTIFICATION BY MASS SPECTROMETRY
scope: NOMENCLATURE

Q9GPE9-citation-29247468
type: Citation Statement
scope: FUNCTION
scope: CATALYTIC ACTIVITY
scope: PROTEIN SEQUENCE OF 22-26
scope: SUBCELLULAR LOCATION
scope: SUBUNIT
scope: IDENTIFICATION BY MASS SPECTROMETRY

PDB 6F5D tt22tt519
chain: D/E/F=22-519

PDB 8APA tt1tt519
chain: D1/E1/F1=1-519

PDB 8APB tt1tt519
chain: D1/E1/F1=1-519

PDB 8APC tt1tt519
chain: D1/E1/F1=1-519

PDB 8APD tt1tt519
chain: D1/E1/F1=1-519

PDB 8APE tt1tt519
chain: D1/E1/F1=1-519

PDB 8APF tt1tt519
chain: D1/E1/F1=1-519

PDB 8APG tt1tt519
chain: D1/E1/F1=1-519

PDB 8APH tt1tt519
chain: D1/E1/F1=1-519

PDB 8APJ tt1tt519
chain: D1/E1/F1=1-519

PDB 8APK tt1tt519
chain: D1/E1/F1=1-519

SIPBD518F1EE7696080
type: Structured Name
full name: ATP synthase subunit beta, mitochondrial
ec name: 7.1.2.2

SIP4C78D3608BC760D9
type: Structured Name
full name: ATP synthase F1 subunit beta

http://purl.uniprot.org/uniprot/Q9GPE9#gene-MD5B0C1D27C209183EBEAC48D5654F5BB89
type: Gene
orf name: Tb427.03.1380

SIP87374AC7F6AA5457
type: Function Annotation
comment: Mitochondrial membrane ATP synthase (F(1)F(o) ATP synthase) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:19436713, PubMed:29247468). F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(o) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk (PubMed:19436713, PubMed:29247468, PubMed:29440423). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1) (PubMed:19436713, PubMed:29440423). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (Probable). Contrary to the procyclic, insect form that requires F(1)F(o) ATP synthase for ATP synthesis, the bloodstream form relies on ATP hydrolysis by F(1)F(o) ATP synthase to maintain its mitochondrial membrane potential (PubMed:29247468).

SIP69792AEE8152ACE2
type: Subunit Annotation
comment: F-type ATPases have 2 components, F(1) - the catalytic core - and F(o) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1), plus the additional subunit P18 (Tb427.05.1710) that is not present in F(1)F(o) ATP synthase from metazoa (PubMed:19436713, PubMed:29247468, PubMed:29440423). Subunit P18 (Tb927.5.1710) interacts with the alpha subunit with a 1:1 stoichiometry; the interaction is direct (PubMed:29440423). Subunit gamma is part of the central stalk (PubMed:29440423). F(o) has three main subunits: a, b and c (PubMed:19436713). The trypanosomal ATPase complex contains additional subunits that are not present in the F(1)F(o) ATP synthase from metazoa (PubMed:19436713, PubMed:29247468, PubMed:29440423).

SIP5032059D5DA9C7E4
type: Similarity Annotation
comment: Belongs to the ATPase alpha/beta chains family.

SIPA09097ACDA198ACD
type: Transit Peptide Annotation
comment: Mitochondrion
range: 22862451565738286tt1tt21

22862451565738286tt1
type: Position
type: ExactPosition
position: 1
reference: Q9GPE9-1

22862451565738286tt21
type: Position
type: ExactPosition
position: 21
reference: Q9GPE9-1

PRO_0000444142
type: Chain Annotation
comment: ATP synthase subunit beta, mitochondrial
mass: 53560
range: 22862451565738286tt22tt519

22862451565738286tt22
type: Position
type: ExactPosition
position: 22
reference: Q9GPE9-1

22862451565738286tt519
type: Position
type: ExactPosition
position: 519
reference: Q9GPE9-1

22862451565738286tt184
type: Position
type: ExactPosition
position: 184
reference: Q9GPE9-1

22862451565738286tt191
type: Position
type: ExactPosition
position: 191
reference: Q9GPE9-1

22862451565738286tt216
type: Position
type: ExactPosition
position: 216
reference: Q9GPE9-1

SIP4D03C251DF120CEC
type: Sequence Conflict Annotation
conflicting sequence: SIP2DA218A29F74DCF7
substitution: PAIPSC
range: 22862451565738286tt441tt447

22862451565738286tt441
type: Position
type: ExactPosition
position: 441
reference: Q9GPE9-1

22862451565738286tt447
type: Position
type: ExactPosition
position: 447
reference: Q9GPE9-1

Q9GPE9-1
type: Simple Sequence
modified: 2018-07-18
version: 2
precursor: true
mass: 55776
value: MLTRFRSAVLRGAVSITGARAASTAPVADHKGRVGHVSQVIGAVVDVHFADGVPPVLTALDVVDKLGRDEPLTLEIVQHLDAHTGRCIAMQTTDLLKLKAKVVSTGGNISVPVGRETLGRIFNVLGDAIDQRGPVGEKLRMPIHAVAPKLADQAAEDAVLTTGIKVIDLILPYCKGGKIGLFGGAGVGKTVIIMELINNVAKGHGGFSVFAGVGERTREGTDLYLEMMQSKVIDLKGESKCVLVYGQMNEPPGARARVAQSALTMAEYFRDVEGQDVLLFIDNIFRFTQANSEVSALLGRIPAAVGYQPTLAEDLGQLQERITSTTKGSITSVQAVYVPADDITDPAPATTFSHLDATTVLDRAVAESGIYPAVNPLECASRIMDPDVISVDHYNVAQDVVQMLTKYRELQDIIAVLGIDELSEEDKLIVDRARKLVKFLSQPFQVAEVFTGMTGHYVQLDDTIDSFSGLLMGTYDQVPEMAFYMVGGINSVLEKAKKMAEEAAELEKMRRARVAQASS

http://purl.uniprot.org/uniprot/Q9GPE9#attribution-1B480056E5F20E01FDE711EB1252A194
manual: true
evidence: ECO_0000250
source: P00829

http://purl.uniprot.org/uniprot/Q9GPE9#attribution-96EC667E15A170A7FBD8BE0B5FD79DE9
manual: true
evidence: ECO_0000255
source: RU003553

http://purl.uniprot.org/uniprot/Q9GPE9#attribution-C992D3F26888652198C0BA8096E05CFF
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/11295183

http://purl.uniprot.org/uniprot/Q9GPE9#attribution-EC60DBAADB015AEB65576AD6611AB712
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/19436713

http://purl.uniprot.org/uniprot/Q9GPE9#attribution-75121C5B1B2A5BC91E219E69630BBBDA
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/29247468

http://purl.uniprot.org/uniprot/Q9GPE9#attribution-A4198AF5F3020F15E0899ED25138CDBC
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/29440423

http://purl.uniprot.org/uniprot/Q9GPE9#attribution-6EA77757B665DF9359F0A949F1BE04B4
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/11295183

http://purl.uniprot.org/uniprot/Q9GPE9#attribution-EC9C13C967678D168E3FF7EFDFE0C32F
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/19436713

http://purl.uniprot.org/uniprot/Q9GPE9#attribution-5F77044BC10B6494AC06E0497E4CAACB
manual: true
evidence: ECO_0000305

http://purl.uniprot.org/uniprot/Q9GPE9#attribution-1B472C41E3184782ED9999C10FF2E803
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/19436713

http://purl.uniprot.org/uniprot/Q9GPE9#attribution-5CAAA3E79F01132F48815E028D57B0FD
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/29247468

http://purl.uniprot.org/uniprot/Q9GPE9#attribution-CC93AA579CEF14279F72BB3C100026D2
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/29440423

http://purl.uniprot.org/uniprot/Q9GPE9#attribution-E05FACF52D5E8AB068C925F5B77235B9
manual: true
evidence: ECO_0000312
source: AAG23340.1

http://purl.uniprot.org/uniprot/Q9GPE9#attribution-4D30C5CB917E8BE258A01D74EC69A1A6
manual: true
evidence: ECO_0007744
source: 6F5D

P0DPG2
type: Protein
reviewed: true
created: 2018-05-23
modified: 2023-02-22
version: 12
mnemonic: ATPD_TRYBB
replaces: A0A2U3T1L6
citation: http://purl.uniprot.org/citations/29440423
citation: http://purl.uniprot.org/citations/19436713
citation: http://purl.uniprot.org/citations/29247468
recommended name: SIPA3CDE00637CF82A6
alternative name: SIPA6546EC602352AAA
organism: http://purl.uniprot.org/taxonomy/5702
annotation: SIP6064DA939AE192BD
annotation: SIP68879A61B6FB2913
annotation: SIP8D74D6FEC68D973B
annotation: SIPC99222A499D02BF6
annotation: SIPF2FEC393D72A2C15
annotation: PRO_0000444144
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/139
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/375
classified with: http://purl.uniprot.org/keywords/999
classified with: http://purl.uniprot.org/keywords/809
classified with: GO_0005743
classified with: GO_0045261
classified with: GO_0046933
sequence: MFRTFGRRLVSCTLPLLQSAPHDLPEGFEFMEHKVVNKDIHAPHENLEXLRLTLTRQDEFLLREEPVKCVTVTGTNGEYGIYPGHAYKIVQLNPSPLTVEYTDGTTKKYFVSGGFAHINNEGSCDVNTVECTLLDDLDLAIAEKELAAQQAALGSAKDDKAKSVVEIRISVIEAVIAALKHH

P0DPG2-citation-29440423
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 18-182
scope: FUNCTION
scope: SUBCELLULAR LOCATION
scope: SUBUNIT

427
type: Strain

P0DPG2-citation-19436713
type: Citation Statement
scope: FUNCTION
scope: SUBCELLULAR LOCATION
scope: SUBUNIT
scope: IDENTIFICATION BY MASS SPECTROMETRY
scope: NOMENCLATURE

P0DPG2-citation-29247468
type: Citation Statement
scope: FUNCTION
scope: PROTEIN SEQUENCE OF 18-22
scope: SUBCELLULAR LOCATION
scope: SUBUNIT
scope: IDENTIFICATION BY MASS SPECTROMETRY

PDB 6F5D tt18tt182
chain: H=18-182

cd12152
type: Resource
database: CDD
comment: F1-ATPase_delta
signature sequence match: CDD cd12152 match 1

http://purl.uniprot.org/gene3d/2.60.15.10
type: Resource
database: Gene3D
comment: F0F1 ATP synthase delta/epsilon subunit, N-terminal
signature sequence match: Gene3D 2.60.15.10 match 1

MF_00530
type: Resource
database: HAMAP
comment: ATP_synth_epsil_bac
signature sequence match: HAMAP MF 00530 match 1

IPR001469
type: Resource
database: InterPro
comment: ATP_synth_F1_dsu/esu

IPR020546
type: Resource
database: InterPro
comment: ATP_synth_F1_dsu/esu_N

IPR036771
type: Resource
database: InterPro
comment: ATPsynth_dsu/esu_N

PTHR13822
type: Resource
database: PANTHER
comment: ATP SYNTHASE DELTA/EPSILON CHAIN
signature sequence match: PANTHER PTHR13822 match 1

PTHR13822:SF7
type: Resource
database: PANTHER
comment: ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL
signature sequence match: PANTHER PTHR13822:SF7 match 1

PF02823
type: Resource
database: Pfam
comment: ATP-synt_DE_N
signature sequence match: Pfam PF02823 match 1

SSF51344
type: Resource
database: SUPFAM
comment: Epsilon subunit of F1F0-ATP synthase N-terminal domain
signature sequence match: SUPFAM SSF51344 match 1

SIPA3CDE00637CF82A6
type: Structured Name
full name: ATP synthase subunit delta, mitochondrial

SIPA6546EC602352AAA
type: Structured Name
full name: ATP synthase F1 subunit delta

http://purl.uniprot.org/uniprot/P0DPG2#gene-MD52EF07A0F5B92497CB8EC2F8357C9BF65
type: Gene
orf name: Tb427.06.4990

SIP6064DA939AE192BD
type: Function Annotation
comment: Mitochondrial membrane ATP synthase (F(1)F(o) ATP synthase) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:19436713, PubMed:29247468). F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(o) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk (PubMed:19436713, PubMed:29247468, PubMed:29440423). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1) (PubMed:19436713, PubMed:29440423). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (Probable). Contrary to the procyclic, insect form that requires F(1)F(o) ATP synthase for ATP synthesis, the bloodstream form relies on ATP hydrolysis by F(1)F(o) ATP synthase to maintain its mitochondrial membrane potential (PubMed:29247468).

SIP68879A61B6FB2913
type: Subunit Annotation
comment: F-type ATPases have 2 components, F(1) - the catalytic core - and F(o) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1), plus the additional subunit P18 (Tb427.05.1710) that is not present in F(1)F(o) ATP synthase from metazoa (PubMed:19436713, PubMed:29247468, PubMed:29440423). Subunit P18 (Tb927.5.1710) interacts with the alpha subunit with a 1:1 stoichiometry; the interaction is direct (PubMed:29440423). Subunit gamma is part of the central stalk (PubMed:29440423). F(o) has three main subunits: a, b and c (PubMed:19436713). The trypanosomal ATPase complex contains additional subunits that are not present in the F(1)F(o) ATP synthase from metazoa (PubMed:19436713, PubMed:29247468, PubMed:29440423).

SIPC99222A499D02BF6
type: Similarity Annotation
comment: Belongs to the ATPase epsilon chain family.

SIPF2FEC393D72A2C15
type: Transit Peptide Annotation
comment: Mitochondrion
range: 22571068099605038tt1tt17

22571068099605038tt1
type: Position
type: ExactPosition
position: 1
reference: MFRTFGRRLVSCTLPLLQSAPHDLPEGFEFMEHKVVNKDIHAPHENLEXLRLTLTRQDEFLLREEPVKCVTVTGTNGEYGIYPGHAYKIVQLNPSPLTVEYTDGTTKKYFVSGGFAHINNEGSCDVNTVECTLLDDLDLAIAEKELAAQQAALGSAKDDKAKSVVEIRISVIEAVIAALKHH

22571068099605038tt17
type: Position
type: ExactPosition
position: 17
reference: MFRTFGRRLVSCTLPLLQSAPHDLPEGFEFMEHKVVNKDIHAPHENLEXLRLTLTRQDEFLLREEPVKCVTVTGTNGEYGIYPGHAYKIVQLNPSPLTVEYTDGTTKKYFVSGGFAHINNEGSCDVNTVECTLLDDLDLAIAEKELAAQQAALGSAKDDKAKSVVEIRISVIEAVIAALKHH

PRO_0000444144
type: Chain Annotation
comment: ATP synthase subunit delta, mitochondrial
mass: 18165
range: 22571068099605038tt18tt182

22571068099605038tt18
type: Position
type: ExactPosition
position: 18
reference: MFRTFGRRLVSCTLPLLQSAPHDLPEGFEFMEHKVVNKDIHAPHENLEXLRLTLTRQDEFLLREEPVKCVTVTGTNGEYGIYPGHAYKIVQLNPSPLTVEYTDGTTKKYFVSGGFAHINNEGSCDVNTVECTLLDDLDLAIAEKELAAQQAALGSAKDDKAKSVVEIRISVIEAVIAALKHH

22571068099605038tt182
type: Position
type: ExactPosition
position: 182
reference: MFRTFGRRLVSCTLPLLQSAPHDLPEGFEFMEHKVVNKDIHAPHENLEXLRLTLTRQDEFLLREEPVKCVTVTGTNGEYGIYPGHAYKIVQLNPSPLTVEYTDGTTKKYFVSGGFAHINNEGSCDVNTVECTLLDDLDLAIAEKELAAQQAALGSAKDDKAKSVVEIRISVIEAVIAALKHH

MFRTFGRRLVSCTLPLLQSAPHDLPEGFEFMEHKVVNKDIHAPHENLEXLRLTLTRQDEFLLREEPVKCVTVTGTNGEYGIYPGHAYKIVQLNPSPLTVEYTDGTTKKYFVSGGFAHINNEGSCDVNTVECTLLDDLDLAIAEKELAAQQAALGSAKDDKAKSVVEIRISVIEAVIAALKHH
type: Simple Sequence
modified: 2018-05-23
version: 1
precursor: true
mass: 20157

http://purl.uniprot.org/uniprot/P0DPG2#attribution-E3D6459752F4AD97E20E2B48F890D042
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/19436713

http://purl.uniprot.org/uniprot/P0DPG2#attribution-AE64254AA02626AD2D4839443424938C
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/29247468

http://purl.uniprot.org/uniprot/P0DPG2#attribution-A4198AF5F3020F15E0899ED25138CDBC
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/29440423

http://purl.uniprot.org/uniprot/P0DPG2#attribution-EC9C13C967678D168E3FF7EFDFE0C32F
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/19436713

http://purl.uniprot.org/uniprot/P0DPG2#attribution-5F77044BC10B6494AC06E0497E4CAACB
manual: true
evidence: ECO_0000305

http://purl.uniprot.org/uniprot/P0DPG2#attribution-1B472C41E3184782ED9999C10FF2E803
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/19436713

http://purl.uniprot.org/uniprot/P0DPG2#attribution-BC3BEB0173CC9E739DBF550186D8F5E5
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/29247468

http://purl.uniprot.org/uniprot/P0DPG2#attribution-CC93AA579CEF14279F72BB3C100026D2
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/29440423

P31477
type: Protein
reviewed: true
created: 1993-07-01
modified: 2023-02-22
version: 109
mnemonic: ATPE_EUGGR
citation: http://purl.uniprot.org/citations/7923415
citation: http://purl.uniprot.org/citations/8346031
recommended name: SIP1CFCACBC869DD70F
alternative name: SIP1A3B8E10330D1A15
alternative name: SIPA309F3952E20E34C
organism: http://purl.uniprot.org/taxonomy/3039
encoded in: Chloroplast
annotation: SIP06738969AC52B7F9
annotation: SIP81DC5187D6036A87
annotation: SIP26598FB410981D74
annotation: SIP08DFF0B63516EC20
annotation: PRO_0000188264
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/139
classified with: http://purl.uniprot.org/keywords/150
classified with: http://purl.uniprot.org/keywords/375
classified with: http://purl.uniprot.org/keywords/472
classified with: http://purl.uniprot.org/keywords/793
classified with: GO_0009535
classified with: GO_0045261
classified with: GO_0005524
classified with: GO_0046933
sequence: MTLDVSIIIPERVFWEKRVEEIILPTLSGQMGVLKDHIPILTGLDIGIILVRQKSSSDWTSLVVTGGFALINSNNVTILVNEAEFGSEINVEQAQISYNSSKHALEMNKDIKRKFELTLNLKKARARFQVTQLKK

P31477-citation-7923415
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

Z / UTEX 753
type: Strain

P31477-citation-8346031
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

S34913
type: Resource
database: PIR
comment: S34546

PTHR13822:SF10
type: Resource
database: PANTHER
comment: ATP SYNTHASE EPSILON CHAIN, CHLOROPLASTIC
signature sequence match: PANTHER PTHR13822:SF10 match 1

TIGR01216
type: Resource
database: TIGRFAMs
comment: ATP_synt_epsi
signature sequence match: TIGRFAMs TIGR01216 match 1

SIP1CFCACBC869DD70F
type: Structured Name
full name: ATP synthase epsilon chain, chloroplastic

SIP1A3B8E10330D1A15
type: Structured Name
full name: ATP synthase F1 sector epsilon subunit

SIPA309F3952E20E34C
type: Structured Name
full name: F-ATPase epsilon subunit

atpE
type: Gene

SIP06738969AC52B7F9
type: Function Annotation
comment: Produces ATP from ADP in the presence of a proton gradient across the membrane.

SIP81DC5187D6036A87
type: Subunit Annotation
comment: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.

SIP08DFF0B63516EC20
type: Similarity Annotation
comment: Belongs to the ATPase epsilon chain family.

PRO_0000188264
type: Chain Annotation
comment: ATP synthase epsilon chain, chloroplastic
mass: 15222
range: 22574284559300398tt1tt135

22574284559300398tt1
type: Position
type: ExactPosition
position: 1
reference: MTLDVSIIIPERVFWEKRVEEIILPTLSGQMGVLKDHIPILTGLDIGIILVRQKSSSDWTSLVVTGGFALINSNNVTILVNEAEFGSEINVEQAQISYNSSKHALEMNKDIKRKFELTLNLKKARARFQVTQLKK

22574284559300398tt135
type: Position
type: ExactPosition
position: 135
reference: MTLDVSIIIPERVFWEKRVEEIILPTLSGQMGVLKDHIPILTGLDIGIILVRQKSSSDWTSLVVTGGFALINSNNVTILVNEAEFGSEINVEQAQISYNSSKHALEMNKDIKRKFELTLNLKKARARFQVTQLKK

MTLDVSIIIPERVFWEKRVEEIILPTLSGQMGVLKDHIPILTGLDIGIILVRQKSSSDWTSLVVTGGFALINSNNVTILVNEAEFGSEINVEQAQISYNSSKHALEMNKDIKRKFELTLNLKKARARFQVTQLKK
type: Simple Sequence
modified: 1993-07-01
version: 1
mass: 15222

http://purl.uniprot.org/uniprot/P31477#attribution-010E2FDA382798F3C5F7883FA248BBDD
manual: true
evidence: ECO_0000255
source: MF_00530

P30393
type: Protein
reviewed: true
created: 1993-04-01
modified: 2023-02-22
version: 95
mnemonic: ATPF_EUGGR
citation: http://purl.uniprot.org/citations/8435857
citation: http://purl.uniprot.org/citations/8346031
recommended name: SIP4C15C530C63ADA41
alternative name: SIP2DA520AFF070A505
alternative name: SIP21033C35161E7941
organism: http://purl.uniprot.org/taxonomy/3039
encoded in: Chloroplast
annotation: SIPDFE98B2C07B62EE6
annotation: SIP66E620C0B0C8767A
annotation: SIP3353B37E6C739204
annotation: SIP4AFDB27898664979
annotation: SIPC4C7B10BF29AE812
annotation: SIP9AFCB678FCC79738
annotation: PRO_0000082407
annotation: SIP69340920D0E6035D
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/66
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/138
classified with: http://purl.uniprot.org/keywords/150
classified with: http://purl.uniprot.org/keywords/793
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0009535
classified with: GO_0045263
classified with: GO_0005524
classified with: GO_0046933
sequence: MVIDNFNIFTIISNAKTFGINTNVFETNIINLAIVVGTLFYYGKLTLSDLLKTRKKTIIKNILDIDEKIRSSQSSLYLAELEFENAAKKASLIRSNGTTFCLKSFDIIRSSVNEDIKRLKQSKRLILRTEDKKSVREIFKNLYSQACQKAKATIIKRLNSKIHKKIILKKMEKMSLKKLKPKY

P30393-citation-8435857
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

Z / UTEX 753
type: Strain

P30393-citation-8346031
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

S29800
type: Resource
database: PIR
comment: PWEGI

cd06503
type: Resource
database: CDD
comment: ATP-synt_Fo_b
signature sequence match: CDD cd06503 match 1

MF_01398
type: Resource
database: HAMAP
comment: ATP_synth_b_bprime
signature sequence match: HAMAP MF 01398 match 1

IPR002146
type: Resource
database: InterPro
comment: ATP_synth_b/b'su_bac/chlpt

PTHR34264
type: Resource
database: PANTHER
comment: ATP SYNTHASE SUBUNIT B, CHLOROPLASTIC
signature sequence match: PANTHER PTHR34264 match 1

PTHR34264:SF3
type: Resource
database: PANTHER
comment: ATP SYNTHASE SUBUNIT B, CHLOROPLASTIC
signature sequence match: PANTHER PTHR34264:SF3 match 1

PF00430
type: Resource
database: Pfam
comment: ATP-synt_B
signature sequence match: Pfam PF00430 match 1

SIP4C15C530C63ADA41
type: Structured Name
full name: ATP synthase subunit b, chloroplastic

SIP2DA520AFF070A505
type: Structured Name
full name: ATP synthase F(0) sector subunit b

SIP21033C35161E7941
type: Structured Name
full name: ATPase subunit I

atpF
type: Gene

SIPDFE98B2C07B62EE6
type: Function Annotation
comment: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.

SIP66E620C0B0C8767A
type: Function Annotation
comment: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).

SIP3353B37E6C739204
type: Subunit Annotation
comment: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has four main subunits: a(1), b(1), b'(1) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta, b and b' chains.

SIPC4C7B10BF29AE812
type: Annotation
comment: In plastids the F-type ATPase is also known as CF(1)CF(0).

SIP9AFCB678FCC79738
type: Similarity Annotation
comment: Belongs to the ATPase B chain family.

PRO_0000082407
type: Chain Annotation
comment: ATP synthase subunit b, chloroplastic
mass: 21127
range: 22574280247685934tt1tt183

22574280247685934tt1
type: Position
type: ExactPosition
position: 1
reference: MVIDNFNIFTIISNAKTFGINTNVFETNIINLAIVVGTLFYYGKLTLSDLLKTRKKTIIKNILDIDEKIRSSQSSLYLAELEFENAAKKASLIRSNGTTFCLKSFDIIRSSVNEDIKRLKQSKRLILRTEDKKSVREIFKNLYSQACQKAKATIIKRLNSKIHKKIILKKMEKMSLKKLKPKY

22574280247685934tt183
type: Position
type: ExactPosition
position: 183
reference: MVIDNFNIFTIISNAKTFGINTNVFETNIINLAIVVGTLFYYGKLTLSDLLKTRKKTIIKNILDIDEKIRSSQSSLYLAELEFENAAKKASLIRSNGTTFCLKSFDIIRSSVNEDIKRLKQSKRLILRTEDKKSVREIFKNLYSQACQKAKATIIKRLNSKIHKKIILKKMEKMSLKKLKPKY

SIP69340920D0E6035D
type: Transmembrane Annotation
comment: Helical
range: 22574280247685934tt20tt42

22574280247685934tt20
type: Position
type: ExactPosition
position: 20
reference: MVIDNFNIFTIISNAKTFGINTNVFETNIINLAIVVGTLFYYGKLTLSDLLKTRKKTIIKNILDIDEKIRSSQSSLYLAELEFENAAKKASLIRSNGTTFCLKSFDIIRSSVNEDIKRLKQSKRLILRTEDKKSVREIFKNLYSQACQKAKATIIKRLNSKIHKKIILKKMEKMSLKKLKPKY

22574280247685934tt42
type: Position
type: ExactPosition
position: 42
reference: MVIDNFNIFTIISNAKTFGINTNVFETNIINLAIVVGTLFYYGKLTLSDLLKTRKKTIIKNILDIDEKIRSSQSSLYLAELEFENAAKKASLIRSNGTTFCLKSFDIIRSSVNEDIKRLKQSKRLILRTEDKKSVREIFKNLYSQACQKAKATIIKRLNSKIHKKIILKKMEKMSLKKLKPKY

MVIDNFNIFTIISNAKTFGINTNVFETNIINLAIVVGTLFYYGKLTLSDLLKTRKKTIIKNILDIDEKIRSSQSSLYLAELEFENAAKKASLIRSNGTTFCLKSFDIIRSSVNEDIKRLKQSKRLILRTEDKKSVREIFKNLYSQACQKAKATIIKRLNSKIHKKIILKKMEKMSLKKLKPKY
type: Simple Sequence
modified: 1993-04-01
version: 1
mass: 21127

http://purl.uniprot.org/uniprot/P30393#attribution-F532F36C147A4DB2E74653A5DA543EB9
manual: true
evidence: ECO_0000255
source: MF_01398

A0A161CFW5
type: Protein
reviewed: true
created: 2018-05-23
modified: 2023-02-22
version: 22
mnemonic: ATPG_TRYBB
replaces: A0A2U3T1L4
citation: http://purl.uniprot.org/citations/27518185
citation: http://purl.uniprot.org/citations/29440423
citation: SIPD251F571CC23A6BA
citation: http://purl.uniprot.org/citations/19436713
citation: http://purl.uniprot.org/citations/29247468
recommended name: SIP6A710E94943B7B3E
alternative name: SIP1F141511EF164564
alternative name: SIP3533D9388E15A75E
organism: http://purl.uniprot.org/taxonomy/5702
annotation: SIPDBCC510277C797CE
annotation: SIPCBB2EFBC35F27E78
annotation: SIP3552FDFBAF4EB973
annotation: SIP8B7B795154096F5D
annotation: SIP3CFF6EEC6A00BD98
annotation: PRO_0000444143
annotation: SIPACC42EC9BE096309
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/139
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/375
classified with: http://purl.uniprot.org/keywords/378
classified with: http://purl.uniprot.org/keywords/999
classified with: GO_0005743
classified with: GO_0045261
classified with: GO_0016787
classified with: GO_0046933
sequence: A0A161CFW5-1

A0A161CFW5-citation-27518185
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: FUNCTION
scope: MUTAGENESIS OF 284-SER--LYS-305

427
type: Strain

A0A161CFW5-citation-29440423
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS)
scope: FUNCTION
scope: SUBCELLULAR LOCATION
scope: SUBUNIT

SIPD251F571CC23A6BA
type: Submission Citation
author: Birhanu H.A.
author: Tadesse G.
author: Goddeeris B.M.
author: Van Reet N.
author: Buscher P.
date: 2015-10
submitted to: EMBL/GenBank/DDBJ

…
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

A0A161CFW5-citation-19436713
type: Citation Statement
scope: FUNCTION
scope: SUBCELLULAR LOCATION
scope: SUBUNIT
scope: IDENTIFICATION BY MASS SPECTROMETRY
scope: NOMENCLATURE

A0A161CFW5-citation-29247468
type: Citation Statement
scope: FUNCTION
scope: PROTEIN SEQUENCE OF 2-6
scope: SUBCELLULAR LOCATION
scope: SUBUNIT
scope: IDENTIFICATION BY MASS SPECTROMETRY

PDB 6F5D tt2tt305
chain: G=2-305

cd12151
type: Resource
database: CDD
comment: F1-ATPase_gamma
signature sequence match: CDD cd12151 match 1

http://purl.uniprot.org/gene3d/1.10.287.80
type: Resource
database: Gene3D
comment: ATP synthase, gamma subunit, helix hairpin domain
signature sequence match: Gene3D 1.10.287.80 match 1

IPR035968
type: Resource
database: InterPro
comment: ATP_synth_F1_ATPase_gsu

IPR000131
type: Resource
database: InterPro
comment: ATP_synth_F1_gsu

PTHR11693
type: Resource
database: PANTHER
comment: ATP SYNTHASE GAMMA CHAIN
signature sequence match: PANTHER PTHR11693 match 1

PTHR11693:SF22
type: Resource
database: PANTHER
comment: ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL
signature sequence match: PANTHER PTHR11693:SF22 match 1

PF00231
type: Resource
database: Pfam
comment: ATP-synt
signature sequence match: Pfam PF00231 match 1

PR00126
type: Resource
database: PRINTS
comment: ATPASEGAMMA

SSF52943
type: Resource
database: SUPFAM
comment: ATP synthase (F1-ATPase), gamma subunit
signature sequence match: SUPFAM SSF52943 match 1

SIP6A710E94943B7B3E
type: Structured Name
full name: ATP synthase subunit gamma, mitochondrial

SIP1F141511EF164564
type: Structured Name
full name: ATP synthase F1 subunit gamma

SIP3533D9388E15A75E
type: Structured Name
full name: F(1)F(o)-ATPase gamma subunit

ATPF1G
type: Gene
orf name: Tb427.10.180

SIPDBCC510277C797CE
type: Function Annotation
comment: Mitochondrial membrane ATP synthase (F(1)F(o) ATP synthase) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:19436713, PubMed:29247468). F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(o) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk (PubMed:19436713, PubMed:29247468, PubMed:29440423). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1) (PubMed:19436713, PubMed:29440423). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (Probable). Contrary to the procyclic, insect form that requires F(1)F(o) ATP synthase for ATP synthesis, the bloodstream form relies on ATP hydrolysis by F(1)F(o) ATP synthase to maintain its mitochondrial membrane potential (PubMed:29247468).

SIPCBB2EFBC35F27E78
type: Subunit Annotation
comment: F-type ATPases have 2 components, F(1) - the catalytic core - and F(o) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1), plus the additional subunit P18 (Tb427.05.1710) that is not present in F(1)F(o) ATP synthase from metazoa (PubMed:19436713, PubMed:29247468, PubMed:29440423). Subunit P18 (Tb927.5.1710) interacts with the alpha subunit with a 1:1 stoichiometry; the interaction is direct (PubMed:29440423). Subunit gamma is part of the central stalk (PubMed:29440423). F(o) has three main subunits: a, b and c (PubMed:19436713). The trypanosomal ATPase complex contains additional subunits that are not present in the F(1)F(o) ATP synthase from metazoa (PubMed:19436713, PubMed:29247468, PubMed:29440423).

SIP8B7B795154096F5D
type: Similarity Annotation
comment: Belongs to the ATPase gamma chain family.

SIP3CFF6EEC6A00BD98
type: Initiator Methionine Annotation
comment: Removed
range: -9218582146293574610tt1tt1

-9218582146293574610tt1
type: Position
type: ExactPosition
position: 1
reference: A0A161CFW5-1

PRO_0000444143
type: Chain Annotation
comment: ATP synthase subunit gamma, mitochondrial
mass: 34269
range: -9218582146293574610tt2tt305

-9218582146293574610tt2
type: Position
type: ExactPosition
position: 2
reference: A0A161CFW5-1

-9218582146293574610tt305
type: Position
type: ExactPosition
position: 305
reference: A0A161CFW5-1

SIPACC42EC9BE096309
type: Mutagenesis Annotation
comment: Confers resistance to killing by ethidium bromide and isometamidium. Decreases mitochondrial membrane potential, and increases time required to reach lethal levels of parasitemia in vivo. Loss of the kinetoplast, a specialized mitochondrial structure that harbors the mitochondrial genome.
range: -9218582146293574610tt284tt305

-9218582146293574610tt284
type: Position
type: ExactPosition
position: 284
reference: A0A161CFW5-1

A0A161CFW5-1
type: Simple Sequence
modified: 2016-07-06
version: 1
mass: 34400
value: MSGKLRLYKEKLEGYNRFYSIVKTIKMVTLAKYRAAQGRIRTRDFSLRYTELAFSKPQASRDAVAAAKNALVYIPITTNRGSCGALNSNIVRCIDSVVSSKMVLMPVGKRGIDSFSKLYPDEFRYGIINDMKESMHFGYATFVIENAYEVSKDADRYQVIFNRFVSAGVQRNAVYNIPSYEKWKEDLADAASSDNQKNRYLFANALQNEEEQLIRDFFDFHAALAVLNAVGENELSEQAARLVAVEGQLTNISSLQQRTSSLYNKTRQFGITAALIEILSAMSSLEGNAMKGVRRNKFWEGAVTK

http://purl.uniprot.org/uniprot/A0A161CFW5#attribution-E3D6459752F4AD97E20E2B48F890D042
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/19436713

http://purl.uniprot.org/uniprot/A0A161CFW5#attribution-966EC3C4340820A1528F861D5247D907
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/27518185

http://purl.uniprot.org/uniprot/A0A161CFW5#attribution-AE64254AA02626AD2D4839443424938C
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/29247468

http://purl.uniprot.org/uniprot/A0A161CFW5#attribution-A4198AF5F3020F15E0899ED25138CDBC
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/29440423

http://purl.uniprot.org/uniprot/A0A161CFW5#attribution-EC9C13C967678D168E3FF7EFDFE0C32F
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/19436713

http://purl.uniprot.org/uniprot/A0A161CFW5#attribution-74295F36AC58629EFE77B4BBFFA35DE6
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/27518185

http://purl.uniprot.org/uniprot/A0A161CFW5#attribution-5F77044BC10B6494AC06E0497E4CAACB
manual: true
evidence: ECO_0000305

http://purl.uniprot.org/uniprot/A0A161CFW5#attribution-1B472C41E3184782ED9999C10FF2E803
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/19436713

http://purl.uniprot.org/uniprot/A0A161CFW5#attribution-BC3BEB0173CC9E739DBF550186D8F5E5
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/29247468

http://purl.uniprot.org/uniprot/A0A161CFW5#attribution-CC93AA579CEF14279F72BB3C100026D2
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/29440423

http://purl.uniprot.org/uniprot/A0A161CFW5#attribution-A4CB42A8C52891D3D6425470850B842E
manual: true
evidence: ECO_0000312
source: ALK02525.1

http://purl.uniprot.org/uniprot/A0A161CFW5#attribution-5394F25174EE9F86DB70431203AC9385
manual: true
evidence: ECO_0000312
source: AOF47129.1

P10603
type: Protein
reviewed: true
created: 1989-07-01
modified: 2023-02-22
version: 125
mnemonic: ATPH_EUGGR
citation: http://purl.uniprot.org/citations/8435857
citation: SIP4CA2BE8C584B2A91
citation: http://purl.uniprot.org/citations/8346031
recommended name: SIPFD5EE3A97A6AD8E5
alternative name: SIPB0BFD942ED335F81
alternative name: SIP2B432A36BA119FAE
alternative name: SIP36C9FA1BB6433AC0
alternative name: SIP47A478988503071F
organism: http://purl.uniprot.org/taxonomy/3039
encoded in: Chloroplast
annotation: SIPCC11B268D44E347F
annotation: SIPFEE5150D0BB16452
annotation: SIPFCCFF976507B6470
annotation: SIPA08F1BA8525A3CB8
annotation: SIP83C36342B3D5CE10
annotation: SIP3A4171DE1E06C0AC
annotation: PRO_0000112187
annotation: SIPAF441E71B0D8E1D6
annotation: SIP59765C0D98E66D20
annotation: SIPE5A1CBD1ECC18D4A
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/66
classified with: http://purl.uniprot.org/keywords/138
classified with: http://purl.uniprot.org/keywords/150
classified with: http://purl.uniprot.org/keywords/446
classified with: http://purl.uniprot.org/keywords/793
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0009535
classified with: GO_0045263
classified with: GO_0008289
classified with: GO_0046933
sequence: MNPIICAASVIGAGLAIGLGAIGPGIGQGTASGKAIEGLARQPEAEGKIRGTLLLSLAFMEALTIYGLVVALAIIFANPFV

P10603-citation-8435857
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

Z / UTEX 753
type: Strain

P10603-citation-SIP4CA2BE8C584B2A91
type: Citation Statement
scope: PRELIMINARY NUCLEOTIDE SEQUENCE [GENOMIC DNA]

P10603-citation-8346031
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

EMBL AAA84220.1
comment: Sequence problems.

S07400
type: Resource
database: PIR
comment: PWQFL

S34901
type: Resource
database: PIR
comment: LWEGC

cd18183
type: Resource
database: CDD
comment: ATP-synt_Fo_c_ATPH
signature sequence match: CDD cd18183 match 1

http://purl.uniprot.org/gene3d/1.20.20.10
type: Resource
database: Gene3D
comment: F1F0 ATP synthase subunit C
signature sequence match: Gene3D 1.20.20.10 match 1

MF_01396
type: Resource
database: HAMAP
comment: ATP_synth_c_bact
signature sequence match: HAMAP MF 01396 match 1

IPR005953
type: Resource
database: InterPro
comment: ATP_synth_csu_bac/chlpt

IPR000454
type: Resource
database: InterPro
comment: ATP_synth_F0_csu

IPR020537
type: Resource
database: InterPro
comment: ATP_synth_F0_csu_DDCD_BS

IPR038662
type: Resource
database: InterPro
comment: ATP_synth_F0_csu_sf

IPR002379
type: Resource
database: InterPro
comment: ATPase_proteolipid_c-like_dom

IPR035921
type: Resource
database: InterPro
comment: F/V-ATP_Csub_sf

PTHR10031
type: Resource
database: PANTHER
comment: ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL
signature sequence match: PANTHER PTHR10031 match 1

PTHR10031:SF48
type: Resource
database: PANTHER
comment: ATP SYNTHASE SUBUNIT C, CHLOROPLASTIC
signature sequence match: PANTHER PTHR10031:SF48 match 1

PF00137
type: Resource
database: Pfam
comment: ATP-synt_C
signature sequence match: Pfam PF00137 match 1

PR00124
type: Resource
database: PRINTS
comment: ATPASEC

SSF81333
type: Resource
database: SUPFAM
comment: F1F0 ATP synthase subunit C
signature sequence match: SUPFAM SSF81333 match 1

TIGR01260
type: Resource
database: TIGRFAMs
comment: ATP_synt_c
signature sequence match: TIGRFAMs TIGR01260 match 1

PS00605
type: Resource
database: PROSITE
comment: ATPASE_C
signature sequence match: PROSITE PS00605 match 1

SIPFD5EE3A97A6AD8E5
type: Structured Name
full name: ATP synthase subunit c, chloroplastic

SIPB0BFD942ED335F81
type: Structured Name
full name: ATP synthase F(0) sector subunit c

SIP2B432A36BA119FAE
type: Structured Name
full name: ATPase subunit III

SIP36C9FA1BB6433AC0
type: Structured Name
full name: F-type ATPase subunit c
short name: F-ATPase subunit c

SIP47A478988503071F
type: Structured Name
full name: Lipid-binding protein

atpH
type: Gene

SIPCC11B268D44E347F
type: Function Annotation
comment: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.

SIPFEE5150D0BB16452
type: Function Annotation
comment: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.

SIPFCCFF976507B6470
type: Subunit Annotation
comment: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has four main subunits: a(1), b(1), b'(1) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta, b and b' chains.

SIP83C36342B3D5CE10
type: Annotation
comment: In plastids the F-type ATPase is also known as CF(1)CF(0).

SIP3A4171DE1E06C0AC
type: Similarity Annotation
comment: Belongs to the ATPase C chain family.

PRO_0000112187
type: Chain Annotation
comment: ATP synthase subunit c, chloroplastic
mass: 8021
range: 22572081274172206tt1tt81

22572081274172206tt1
type: Position
type: ExactPosition
position: 1
reference: MNPIICAASVIGAGLAIGLGAIGPGIGQGTASGKAIEGLARQPEAEGKIRGTLLLSLAFMEALTIYGLVVALAIIFANPFV

22572081274172206tt81
type: Position
type: ExactPosition
position: 81
reference: MNPIICAASVIGAGLAIGLGAIGPGIGQGTASGKAIEGLARQPEAEGKIRGTLLLSLAFMEALTIYGLVVALAIIFANPFV

SIPAF441E71B0D8E1D6
type: Transmembrane Annotation
comment: Helical
range: 22572081274172206tt3tt23

22572081274172206tt3
type: Position
type: ExactPosition
position: 3
reference: MNPIICAASVIGAGLAIGLGAIGPGIGQGTASGKAIEGLARQPEAEGKIRGTLLLSLAFMEALTIYGLVVALAIIFANPFV

22572081274172206tt23
type: Position
type: ExactPosition
position: 23
reference: MNPIICAASVIGAGLAIGLGAIGPGIGQGTASGKAIEGLARQPEAEGKIRGTLLLSLAFMEALTIYGLVVALAIIFANPFV

SIP59765C0D98E66D20
type: Transmembrane Annotation
comment: Helical
range: 22572081274172206tt57tt77

22572081274172206tt57
type: Position
type: ExactPosition
position: 57
reference: MNPIICAASVIGAGLAIGLGAIGPGIGQGTASGKAIEGLARQPEAEGKIRGTLLLSLAFMEALTIYGLVVALAIIFANPFV

22572081274172206tt77
type: Position
type: ExactPosition
position: 77
reference: MNPIICAASVIGAGLAIGLGAIGPGIGQGTASGKAIEGLARQPEAEGKIRGTLLLSLAFMEALTIYGLVVALAIIFANPFV

SIPE5A1CBD1ECC18D4A
type: Site Annotation
comment: Reversibly protonated during proton transport
range: 22572081274172206tt61tt61

22572081274172206tt61
type: Position
type: ExactPosition
position: 61
reference: MNPIICAASVIGAGLAIGLGAIGPGIGQGTASGKAIEGLARQPEAEGKIRGTLLLSLAFMEALTIYGLVVALAIIFANPFV

MNPIICAASVIGAGLAIGLGAIGPGIGQGTASGKAIEGLARQPEAEGKIRGTLLLSLAFMEALTIYGLVVALAIIFANPFV
type: Simple Sequence
modified: 1993-04-01
version: 2
mass: 8021

http://purl.uniprot.org/uniprot/P10603#attribution-A30093FC3652A8EBF93668C13F9E1E0F
manual: true
evidence: ECO_0000255
source: MF_01396

P30391
type: Protein
reviewed: true
created: 1993-04-01
modified: 2023-02-22
version: 113
mnemonic: ATPI_EUGGR
citation: http://purl.uniprot.org/citations/8435857
citation: http://purl.uniprot.org/citations/8346031
recommended name: SIP2E10B36910B65970
alternative name: SIPAAE750EF5DEF8F79
alternative name: SIPE87FCFA54CD25CF4
organism: http://purl.uniprot.org/taxonomy/3039
encoded in: Chloroplast
annotation: SIP84763DFD3875623F
annotation: SIPD3C69DB60125C400
annotation: SIP117596D0B325730B
annotation: SIPDF19FD202790F81F
annotation: PRO_0000002583
annotation: SIP2DDC78C92E046786
annotation: SIPD316C492BEBE70B3
annotation: SIP18CE85ED8EC0E1EA
annotation: SIPBD1D7FA94884EE79
annotation: SIP6A5D441CA4002BAF
annotation: SIPB49905C0DCBDE059
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/66
classified with: http://purl.uniprot.org/keywords/138
classified with: http://purl.uniprot.org/keywords/150
classified with: http://purl.uniprot.org/keywords/793
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0009535
classified with: GO_0005886
classified with: GO_0045263
classified with: GO_0046933
sequence: P30391-1

P30391-citation-8435857
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

Z / UTEX 753
type: Strain

P30391-citation-8346031
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

S29798
type: Resource
database: PIR
comment: PWEGAC

MF_01393
type: Resource
database: HAMAP
comment: ATP_synth_a_bact
signature sequence match: HAMAP MF 01393 match 1

IPR045082
type: Resource
database: InterPro
comment: ATP_syn_F0_a_bact/chloroplast

IPR023011
type: Resource
database: InterPro
comment: ATP_synth_F0_asu_AS

PTHR42823
type: Resource
database: PANTHER
comment: ATP SYNTHASE SUBUNIT A, CHLOROPLASTIC
signature sequence match: PANTHER PTHR42823 match 1

PTHR42823:SF3
type: Resource
database: PANTHER
comment: ATP SYNTHASE SUBUNIT A, CHLOROPLASTIC
signature sequence match: PANTHER PTHR42823:SF3 match 1

TIGR01131
type: Resource
database: TIGRFAMs
comment: ATP_synt_6_or_A
signature sequence match: TIGRFAMs TIGR01131 match 1

PS00449
type: Resource
database: PROSITE
comment: ATPASE_A
signature sequence match: PROSITE PS00449 match 1

SIP2E10B36910B65970
type: Structured Name
full name: ATP synthase subunit a, chloroplastic

SIPAAE750EF5DEF8F79
type: Structured Name
full name: ATP synthase F0 sector subunit a

SIPE87FCFA54CD25CF4
type: Structured Name
full name: F-ATPase subunit IV

atpI
type: Gene

SIP84763DFD3875623F
type: Function Annotation
comment: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.

SIPD3C69DB60125C400
type: Subunit Annotation
comment: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a, b, b' and c.

SIPDF19FD202790F81F
type: Similarity Annotation
comment: Belongs to the ATPase A chain family.

PRO_0000002583
type: Chain Annotation
comment: ATP synthase subunit a, chloroplastic
mass: 28046
range: 22574280247685422tt1tt251

22574280247685422tt1
type: Position
type: ExactPosition
position: 1
reference: P30391-1

22574280247685422tt251
type: Position
type: ExactPosition
position: 251
reference: P30391-1

SIP2DDC78C92E046786
type: Transmembrane Annotation
comment: Helical
range: 22574280247685422tt3tt23

22574280247685422tt3
type: Position
type: ExactPosition
position: 3
reference: P30391-1

22574280247685422tt23
type: Position
type: ExactPosition
position: 23
reference: P30391-1

SIPD316C492BEBE70B3
type: Transmembrane Annotation
comment: Helical
range: 22574280247685422tt38tt58

22574280247685422tt38
type: Position
type: ExactPosition
position: 38
reference: P30391-1

22574280247685422tt58
type: Position
type: ExactPosition
position: 58
reference: P30391-1

SIP18CE85ED8EC0E1EA
type: Transmembrane Annotation
comment: Helical
range: 22574280247685422tt99tt119

22574280247685422tt99
type: Position
type: ExactPosition
position: 99
reference: P30391-1

22574280247685422tt119
type: Position
type: ExactPosition
position: 119
reference: P30391-1

SIPBD1D7FA94884EE79
type: Transmembrane Annotation
comment: Helical
range: 22574280247685422tt138tt158

22574280247685422tt138
type: Position
type: ExactPosition
position: 138
reference: P30391-1

22574280247685422tt158
type: Position
type: ExactPosition
position: 158
reference: P30391-1

SIP6A5D441CA4002BAF
type: Transmembrane Annotation
comment: Helical
range: 22574280247685422tt203tt223

22574280247685422tt203
type: Position
type: ExactPosition
position: 203
reference: P30391-1

22574280247685422tt223
type: Position
type: ExactPosition
position: 223
reference: P30391-1

SIPB49905C0DCBDE059
type: Transmembrane Annotation
comment: Helical
range: 22574280247685422tt224tt244

22574280247685422tt224
type: Position
type: ExactPosition
position: 224
reference: P30391-1

22574280247685422tt244
type: Position
type: ExactPosition
position: 244
reference: P30391-1

P30391-1
type: Simple Sequence
modified: 1993-04-01
version: 1
mass: 28046
value: MKIVLLYYFVNMFISGIFQIANVEVGQHFYWSILGFQIHGQVLINSWIVILIIGFLSIYTTKNLTLVPANKQIFIELVTEFITDISKTQIGEKEYSKWVPYIGTMFLFIFVSNWSGALIPWKIIELPNGELGAPTNDINTTAGLAILTSLAYFYAGLNKKGLTYFKKYVQPTPILLPINILEDFTKPLSLSFRLFGNILADELVVAVLVSLVPLIVPVPLIFLGLFTSGIQALIFATLSGSYIGEAMEGHH

http://purl.uniprot.org/uniprot/P30391#attribution-D994E701E2B83728CB99F3F29F0E9616
manual: true
evidence: ECO_0000255
source: MF_01393

P33447
type: Protein
reviewed: true
created: 1994-02-01
modified: 2023-02-22
version: 129
mnemonic: ATTY_TRYCR
citation: http://purl.uniprot.org/citations/8101971
citation: http://purl.uniprot.org/citations/8100416
citation: http://purl.uniprot.org/citations/10595543
conflicting sequence: SIPEF66415264021D6F
recommended name: SIP5D0AB05257EFA29E
alternative name: SIP151DA34BF39F7191
enzyme: http://purl.uniprot.org/enzyme/2.6.1.5
organism: http://purl.uniprot.org/taxonomy/5693
annotation: SIP3352E83C9D277BF7
annotation: SIPB0531C607B74741F
annotation: SIPDB84E95D9601EBF1
annotation: SIPA23158415D13AED2
annotation: SIP5BB25F1AA65F030A
annotation: SIPBE76E823D64BA0C5
annotation: SIP1EDDCD301F9842CF
annotation: SIP3198501295712EFA
annotation: SIP00A020AFC646420C
annotation: PRO_0000123890
annotation: SIP3CD1F968C02E650C
annotation: SIPA935D75E7B51C23D
annotation: SIPB3CE3C02387A9FAF
annotation: SIP4A4F020A856C18B0
annotation: SIP1C35220DF9C42B13
annotation: SIP38915480B9C156EE
annotation: SIPE055F73D9C1DF94C
annotation: SIP90C23F195E434FAC
annotation: SIP57A4941FC4F055A2
annotation: SIP79117D229B2BBC31
annotation: SIP65CF0E70286DDAE2
annotation: SIP7A683C0D446C09B7
annotation: SIP5EC12F472AB2E990
annotation: SIP13DC2B810B36C454
annotation: SIP112D7328A6431517
annotation: SIPB0AA8614F247B1B9
annotation: SIPDE9A53F590E235DD
annotation: SIP6CA338412005A8D4
annotation: SIPC3E2DC856CFC0024
annotation: SIPA5ADFCF0E15B271C
annotation: SIPB8C26842BC9304DD
annotation: SIP906F8419A113F22E
annotation: SIPF34F9AB5EED353E9
annotation: SIP4DB4D79B78100387
annotation: SIP830382C4140C5FCD
annotation: SIP60C9DAA9A56AF3C5
annotation: SIP36E82387886A263A
annotation: SIP8D386382D52A6D1C
annotation: SIP6A5198336F22BAC4
annotation: SIPC59A41DCAC0EE8CE
annotation: SIPB4D8F87D34DAC535
annotation: SIP158B8B60B7AFBEE4
annotation: SIP403136C6958594BA
annotation: SIP1DF4D400902F1E36
annotation: SIP08496C96F7450AF1
annotation: SIP70003C7C6C255AB6
annotation: SIPB87E60EF85E919F1
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/32
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/496
classified with: http://purl.uniprot.org/keywords/585
classified with: http://purl.uniprot.org/keywords/663
classified with: http://purl.uniprot.org/keywords/828
classified with: GO_0005739
classified with: GO_0004838
classified with: GO_0030170
classified with: GO_0009058
classified with: GO_0006559
classified with: GO_0006572
sequence: P33447-1

P33447-citation-8101971
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE

P33447-citation-8100416
type: Citation Statement
scope: PROTEIN SEQUENCE OF 120-148; 153-167 AND 324-338
scope: CHARACTERIZATION

Tulahuen 0
type: Strain

P33447-citation-10595543
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) IN COMPLEX WITH PYRIDOXAL PHOSPHATE
scope: SUBUNIT
scope: COFACTOR

1BW0
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.50
chain sequence mapping: PDB 1BW0 tt1tt416

PDB 1BW0 tt1tt416
chain: A/B=1-416

DB04083
type: Resource
database: DrugBank
comment: N(6)-(pyridoxal phosphate)-L-lysine

http://purl.uniprot.org/brenda/2.6.1.5
type: Resource
database: BRENDA
comment: 6524

cd00609
type: Resource
database: CDD
comment: AAT_like
signature sequence match: CDD cd00609 match 1

http://purl.uniprot.org/gene3d/3.90.1150.10
type: Resource
database: Gene3D
comment: Aspartate Aminotransferase, domain 1
signature sequence match: Gene3D 3.90.1150.10 match 1

http://purl.uniprot.org/gene3d/3.40.640.10
type: Resource
database: Gene3D
comment: Type I PLP-dependent aspartate aminotransferase-like (Major domain)
signature sequence match: Gene3D 3.40.640.10 match 1

IPR004839
type: Resource
database: InterPro
comment: Aminotransferase_I/II

IPR004838
type: Resource
database: InterPro
comment: NHTrfase_class1_PyrdxlP-BS

IPR015424
type: Resource
database: InterPro
comment: PyrdxlP-dep_Trfase

IPR015421
type: Resource
database: InterPro
comment: PyrdxlP-dep_Trfase_major

IPR015422
type: Resource
database: InterPro
comment: PyrdxlP-dep_Trfase_small

IPR005958
type: Resource
database: InterPro
comment: TyrNic_aminoTrfase

IPR005957
type: Resource
database: InterPro
comment: Tyrosine_aminoTrfase

PTHR45744
type: Resource
database: PANTHER
comment: TYROSINE AMINOTRANSFERASE
signature sequence match: PANTHER PTHR45744 match 1

PTHR45744:SF2
type: Resource
database: PANTHER
comment: TYROSINE AMINOTRANSFERASE
signature sequence match: PANTHER PTHR45744:SF2 match 1

PF00155
type: Resource
database: Pfam
comment: Aminotran_1_2
signature sequence match: Pfam PF00155 match 1

PIRSF000517
type: Resource
database: PIRSF
comment: Tyr_transaminase
signature sequence match: PIRSF PIRSF000517 match 1

SSF53383
type: Resource
database: SUPFAM
comment: PLP-dependent transferases
signature sequence match: SUPFAM SSF53383 match 1

TIGR01264
type: Resource
database: TIGRFAMs
comment: tyr_amTase_E
signature sequence match: TIGRFAMs TIGR01264 match 1

TIGR01265
type: Resource
database: TIGRFAMs
comment: tyr_nico_aTase
signature sequence match: TIGRFAMs TIGR01265 match 1

PS00105
type: Resource
database: PROSITE
comment: AA_TRANSFER_CLASS_1
signature sequence match: PROSITE PS00105 match 1

SIPEF66415264021D6F
type: External Sequence
comment: AA sequence
citation: http://purl.uniprot.org/citations/8100416

SIP5D0AB05257EFA29E
type: Structured Name
full name: Tyrosine aminotransferase
short name: TAT
ec name: 2.6.1.5

SIP151DA34BF39F7191
type: Structured Name
full name: L-tyrosine:2-oxoglutarate aminotransferase

SIP3352E83C9D277BF7
type: Function Annotation
comment: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate (By similarity).

SIP5BB25F1AA65F030A
type: Subunit Annotation
comment: Homodimer.

SIPBE76E823D64BA0C5
type: Subcellular Location Annotation
comment: Mainly cytoplasmic. Present to a small extent in the mitochondrial fraction.
located in: SIPB9D96F17A1A3A0D3
located in: SIP584A1544158993BD

SIP1EDDCD301F9842CF
type: PTM Annotation
comment: The N-terminus is blocked.

SIP3198501295712EFA
type: Similarity Annotation
comment: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

SIP00A020AFC646420C
type: Caution Annotation
comment: Was originally thought to have three internal disulfide bonds.

PRO_0000123890
type: Chain Annotation
comment: Tyrosine aminotransferase
mass: 46167
range: 22574293149038382tt1tt416

22574293149038382tt1
type: Position
type: ExactPosition
position: 1
reference: P33447-1

22574293149038382tt416
type: Position
type: ExactPosition
position: 416
reference: P33447-1

SIP3CD1F968C02E650C
type: Modified Residue Annotation
comment: N6-(pyridoxal phosphate)lysine
range: 22574293149038382tt253tt253

22574293149038382tt253
type: Position
type: ExactPosition
position: 253
reference: P33447-1

SIPA935D75E7B51C23D
type: Sequence Conflict Annotation
conflicting sequence: SIPEF66415264021D6F
substitution: D
range: 22574293149038382tt153tt153

22574293149038382tt153
type: Position
type: ExactPosition
position: 153
reference: P33447-1

22574293149038382tt10
type: Position
type: ExactPosition
position: 10
reference: P33447-1

22574293149038382tt13
type: Position
type: ExactPosition
position: 13
reference: P33447-1

22574293149038382tt18
type: Position
type: ExactPosition
position: 18
reference: P33447-1

22574293149038382tt24
type: Position
type: ExactPosition
position: 24
reference: P33447-1

22574293149038382tt43
type: Position
type: ExactPosition
position: 43
reference: P33447-1

22574293149038382tt46
type: Position
type: ExactPosition
position: 46
reference: P33447-1

22574293149038382tt53
type: Position
type: ExactPosition
position: 53
reference: P33447-1

22574293149038382tt64
type: Position
type: ExactPosition
position: 64
reference: P33447-1

22574293149038382tt68
type: Position
type: ExactPosition
position: 68
reference: P33447-1

22574293149038382tt70
type: Position
type: ExactPosition
position: 70
reference: P33447-1

22574293149038382tt78
type: Position
type: ExactPosition
position: 78
reference: P33447-1

22574293149038382tt92
type: Position
type: ExactPosition
position: 92
reference: P33447-1

22574293149038382tt96
type: Position
type: ExactPosition
position: 96
reference: P33447-1

22574293149038382tt98
type: Position
type: ExactPosition
position: 98
reference: P33447-1

22574293149038382tt99
type: Position
type: ExactPosition
position: 99
reference: P33447-1

22574293149038382tt101
type: Position
type: ExactPosition
position: 101
reference: P33447-1

22574293149038382tt104
type: Position
type: ExactPosition
position: 104
reference: P33447-1

22574293149038382tt106
type: Position
type: ExactPosition
position: 106
reference: P33447-1

22574293149038382tt107
type: Position
type: ExactPosition
position: 107
reference: P33447-1

22574293149038382tt111
type: Position
type: ExactPosition
position: 111
reference: P33447-1

22574293149038382tt112
type: Position
type: ExactPosition
position: 112
reference: P33447-1

22574293149038382tt124
type: Position
type: ExactPosition
position: 124
reference: P33447-1

22574293149038382tt130
type: Position
type: ExactPosition
position: 130
reference: P33447-1

22574293149038382tt136
type: Position
type: ExactPosition
position: 136
reference: P33447-1

22574293149038382tt140
type: Position
type: ExactPosition
position: 140
reference: P33447-1

22574293149038382tt147
type: Position
type: ExactPosition
position: 147
reference: P33447-1

22574293149038382tt151
type: Position
type: ExactPosition
position: 151
reference: P33447-1

22574293149038382tt157
type: Position
type: ExactPosition
position: 157
reference: P33447-1

22574293149038382tt159
type: Position
type: ExactPosition
position: 159
reference: P33447-1

22574293149038382tt161
type: Position
type: ExactPosition
position: 161
reference: P33447-1

22574293149038382tt167
type: Position
type: ExactPosition
position: 167
reference: P33447-1

22574293149038382tt173
type: Position
type: ExactPosition
position: 173
reference: P33447-1

22574293149038382tt178
type: Position
type: ExactPosition
position: 178
reference: P33447-1

22574293149038382tt186
type: Position
type: ExactPosition
position: 186
reference: P33447-1

22574293149038382tt188
type: Position
type: ExactPosition
position: 188
reference: P33447-1

22574293149038382tt190
type: Position
type: ExactPosition
position: 190
reference: P33447-1

22574293149038382tt196
type: Position
type: ExactPosition
position: 196
reference: P33447-1

22574293149038382tt209
type: Position
type: ExactPosition
position: 209
reference: P33447-1

22574293149038382tt213
type: Position
type: ExactPosition
position: 213
reference: P33447-1

22574293149038382tt216
type: Position
type: ExactPosition
position: 216
reference: P33447-1

22574293149038382tt218
type: Position
type: ExactPosition
position: 218
reference: P33447-1

22574293149038382tt221
type: Position
type: ExactPosition
position: 221
reference: P33447-1

22574293149038382tt245
type: Position
type: ExactPosition
position: 245
reference: P33447-1

22574293149038382tt250
type: Position
type: ExactPosition
position: 250
reference: P33447-1

22574293149038382tt258
type: Position
type: ExactPosition
position: 258
reference: P33447-1

22574293149038382tt260
type: Position
type: ExactPosition
position: 260
reference: P33447-1

22574293149038382tt263
type: Position
type: ExactPosition
position: 263
reference: P33447-1

22574293149038382tt268
type: Position
type: ExactPosition
position: 268
reference: P33447-1

22574293149038382tt275
type: Position
type: ExactPosition
position: 275
reference: P33447-1

22574293149038382tt288
type: Position
type: ExactPosition
position: 288
reference: P33447-1

22574293149038382tt293
type: Position
type: ExactPosition
position: 293
reference: P33447-1

22574293149038382tt304
type: Position
type: ExactPosition
position: 304
reference: P33447-1

22574293149038382tt308
type: Position
type: ExactPosition
position: 308
reference: P33447-1

22574293149038382tt329
type: Position
type: ExactPosition
position: 329
reference: P33447-1

22574293149038382tt335
type: Position
type: ExactPosition
position: 335
reference: P33447-1

22574293149038382tt337
type: Position
type: ExactPosition
position: 337
reference: P33447-1

22574293149038382tt345
type: Position
type: ExactPosition
position: 345
reference: P33447-1

22574293149038382tt350
type: Position
type: ExactPosition
position: 350
reference: P33447-1

22574293149038382tt352
type: Position
type: ExactPosition
position: 352
reference: P33447-1

22574293149038382tt354
type: Position
type: ExactPosition
position: 354
reference: P33447-1

22574293149038382tt355
type: Position
type: ExactPosition
position: 355
reference: P33447-1

22574293149038382tt357
type: Position
type: ExactPosition
position: 357
reference: P33447-1

22574293149038382tt361
type: Position
type: ExactPosition
position: 361
reference: P33447-1

22574293149038382tt372
type: Position
type: ExactPosition
position: 372
reference: P33447-1

22574293149038382tt379
type: Position
type: ExactPosition
position: 379
reference: P33447-1

22574293149038382tt382
type: Position
type: ExactPosition
position: 382
reference: P33447-1

22574293149038382tt387
type: Position
type: ExactPosition
position: 387
reference: P33447-1

22574293149038382tt391
type: Position
type: ExactPosition
position: 391
reference: P33447-1

22574293149038382tt396
type: Position
type: ExactPosition
position: 396
reference: P33447-1

22574293149038382tt413
type: Position
type: ExactPosition
position: 413
reference: P33447-1

P33447-1
type: Simple Sequence
modified: 1995-11-01
version: 2
mass: 46167
value: MSSWDVSMSNHAGLVFNPIRTVSDNAKPSPSPKPIIKLSVGDPTLDKNLLTSAAQIKKLKEAIDSQECNGYFPTVGSPEAREAVATWWRNSFVHKEELKSTIVKDNVVLCSGGSHGILMAITAICDAGDYALVPQPGFPHYETVCKAYGIGMHFYNCRPENDWEADLDEIRRLKDDKTKLLIVTNPSNPCGSNFSRKHVEDIVRLAEELRLPLFSDEIYAGMVFKGKDPNATFTSVADFETTVPRVILGGTAKNLVVPGWRLGWLLYVDPHGNGPSFLEGLKRVGMLVCGPCTVVQAALGEALLNTPQEHLDQIVAKIEESAMYLYNHIGECIGLAPTMPRGAMYLMSRIDLEKYRDIKTDVEFFEKLLEEENVQVLPGTIFHAPGFTRLTTTRPVEVYREAVERIKAFCQRHAAV

http://purl.uniprot.org/uniprot/P33447#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/P33447#attribution-C72D2BFDBDBAEFDAE2E4AC264ADD3541
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/10595543

http://purl.uniprot.org/uniprot/P33447#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

http://purl.uniprot.org/uniprot/P33447#attribution-F44D8970304927504C015625B8DB9772
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/8100416

P11718
type: Protein
reviewed: true
created: 1989-10-01
modified: 2023-02-22
version: 142
mnemonic: ATXA_LEIDO
citation: http://purl.uniprot.org/citations/2828921
citation: http://purl.uniprot.org/citations/2469011
recommended name: SIP30D84EFDE2ECB733
alternative name: SIPCD7817A0237BE547
enzyme: http://purl.uniprot.org/enzyme/7.1.2.1
organism: http://purl.uniprot.org/taxonomy/5661
annotation: SIP8B2E3649CA285BBE
annotation: SIPC77CF3806BC33BDA
annotation: SIP65D7B1F5848C5FFE
annotation: SIP1ED560AB10798D02
annotation: PRO_0000046180
annotation: SIP75EC761A7E57C37D
annotation: SIP36AAB737D4405F5C
annotation: SIPC81A37404B37EE9E
annotation: SIPE3B3160F92AB009C
annotation: SIPCCD0D2638BF75F1B
annotation: SIP8526ADDB61A9D225
annotation: SIP90F2BC228B40FC41
annotation: SIPC605D21E4CE1A9C3
annotation: SIPF07F354925FA7330
annotation: SIPBE6600B189768072
annotation: SIPCCD914C21F4B3C66
annotation: SIP995C06B57952DBD3
annotation: SIP8670FAEF231F79F2
annotation: SIP68E37182AC0E72E0
annotation: SIP9C9F860CDCF75149
annotation: SIPF737536CDC5EAF99
annotation: SIPBF4B2323239FC46B
annotation: SIPFF1A522D7E7EB3DC
annotation: SIPFC52096A744182AA
annotation: SIP75B015A8CF9F6118
annotation: SIP9394B668EC0992A0
annotation: SIP40CDBF93C940E46C
annotation: SIP60F9624A07657CDC
annotation: SIPC3C7850A109E825C
annotation: SIP1E433A31054FC092
annotation: SIPC175B13A79DB132B
annotation: SIP62D400BCE7CCC0F9
annotation: SIPC8F8B5FDF56BC453
existence: Evidence at Transcript Level Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/375
classified with: http://purl.uniprot.org/keywords/460
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/597
classified with: http://purl.uniprot.org/keywords/1278
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0016020
classified with: GO_0005524
classified with: GO_0016887
classified with: GO_0046872
classified with: GO_0008553
classified with: GO_0120029
sequence: P11718-1

P11718-citation-2828921
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

P11718-citation-2469011
type: Citation Statement
scope: SEQUENCE REVISION TO 55-56
scope: DEVELOPMENTAL STAGE

MHOM/ET/67/L82
type: Strain

A27124
type: Resource
database: PIR
comment: PXLNPD

3.A.3.3.2
type: Resource
database: TCDB
comment: the p-type atpase (p-atpase) superfamily

cd02076
type: Resource
database: CDD
comment: P-type_ATPase_H
signature sequence match: CDD cd02076 match 1

IPR006534
type: Resource
database: InterPro
comment: P-type_ATPase_IIIA

PTHR42861:SF48
type: Resource
database: PANTHER
comment: PLASMA MEMBRANE ATPASE
signature sequence match: PANTHER PTHR42861:SF48 match 1

PF00702
type: Resource
database: Pfam
comment: Hydrolase
signature sequence match: Pfam PF00702 match 1

PR00120
type: Resource
database: PRINTS
comment: HATPASE

SFLDS00003
type: Resource
database: SFLD
comment: Haloacid_Dehalogenase
signature sequence match: SFLD SFLDS00003 match 1

TIGR01647
type: Resource
database: TIGRFAMs
comment: ATPase-IIIA_H
signature sequence match: TIGRFAMs TIGR01647 match 1

SIP30D84EFDE2ECB733
type: Structured Name
full name: Probable proton ATPase 1A
ec name: 7.1.2.1

SIPCD7817A0237BE547
type: Structured Name
full name: LdH1A

H1A
type: Gene

SIP65D7B1F5848C5FFE
type: Developmental Stage Annotation
comment: More abundant in promastigotes than amastigotes.

SIP1ED560AB10798D02
type: Similarity Annotation
comment: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.

PRO_0000046180
type: Chain Annotation
comment: Probable proton ATPase 1A
mass: 107479
range: 22572085585983534tt1tt974

22572085585983534tt1
type: Position
type: ExactPosition
position: 1
reference: P11718-1

22572085585983534tt974
type: Position
type: ExactPosition
position: 974
reference: P11718-1

SIP75EC761A7E57C37D
type: Topological Domain Annotation
comment: Cytoplasmic
range: 22572085585983534tt1tt92

22572085585983534tt92
type: Position
type: ExactPosition
position: 92
reference: P11718-1

SIP36AAB737D4405F5C
type: Transmembrane Annotation
comment: Helical; Name=1
range: 22572085585983534tt93tt112

22572085585983534tt93
type: Position
type: ExactPosition
position: 93
reference: P11718-1

22572085585983534tt112
type: Position
type: ExactPosition
position: 112
reference: P11718-1

SIPC81A37404B37EE9E
type: Topological Domain Annotation
comment: Extracellular
range: 22572085585983534tt113tt117

22572085585983534tt113
type: Position
type: ExactPosition
position: 113
reference: P11718-1

22572085585983534tt117
type: Position
type: ExactPosition
position: 117
reference: P11718-1

SIPE3B3160F92AB009C
type: Transmembrane Annotation
comment: Helical; Name=2
range: 22572085585983534tt118tt137

22572085585983534tt118
type: Position
type: ExactPosition
position: 118
reference: P11718-1

22572085585983534tt137
type: Position
type: ExactPosition
position: 137
reference: P11718-1

SIPCCD0D2638BF75F1B
type: Topological Domain Annotation
comment: Cytoplasmic
range: 22572085585983534tt138tt264

22572085585983534tt138
type: Position
type: ExactPosition
position: 138
reference: P11718-1

22572085585983534tt264
type: Position
type: ExactPosition
position: 264
reference: P11718-1

SIP8526ADDB61A9D225
type: Transmembrane Annotation
comment: Helical; Name=3
range: 22572085585983534tt265tt286

22572085585983534tt265
type: Position
type: ExactPosition
position: 265
reference: P11718-1

22572085585983534tt286
type: Position
type: ExactPosition
position: 286
reference: P11718-1

SIP90F2BC228B40FC41
type: Topological Domain Annotation
comment: Extracellular
range: 22572085585983534tt287tt294

22572085585983534tt287
type: Position
type: ExactPosition
position: 287
reference: P11718-1

22572085585983534tt294
type: Position
type: ExactPosition
position: 294
reference: P11718-1

SIPC605D21E4CE1A9C3
type: Transmembrane Annotation
comment: Helical; Name=4
range: 22572085585983534tt295tt321

22572085585983534tt295
type: Position
type: ExactPosition
position: 295
reference: P11718-1

22572085585983534tt321
type: Position
type: ExactPosition
position: 321
reference: P11718-1

SIPF07F354925FA7330
type: Topological Domain Annotation
comment: Cytoplasmic
range: 22572085585983534tt322tt630

22572085585983534tt322
type: Position
type: ExactPosition
position: 322
reference: P11718-1

22572085585983534tt630
type: Position
type: ExactPosition
position: 630
reference: P11718-1

SIPBE6600B189768072
type: Transmembrane Annotation
comment: Helical; Name=5
range: 22572085585983534tt631tt651

22572085585983534tt631
type: Position
type: ExactPosition
position: 631
reference: P11718-1

22572085585983534tt651
type: Position
type: ExactPosition
position: 651
reference: P11718-1

SIPCCD914C21F4B3C66
type: Topological Domain Annotation
comment: Extracellular
range: 22572085585983534tt652tt661

22572085585983534tt652
type: Position
type: ExactPosition
position: 652
reference: P11718-1

22572085585983534tt661
type: Position
type: ExactPosition
position: 661
reference: P11718-1

SIP995C06B57952DBD3
type: Transmembrane Annotation
comment: Helical; Name=6
range: 22572085585983534tt662tt684

22572085585983534tt662
type: Position
type: ExactPosition
position: 662
reference: P11718-1

22572085585983534tt684
type: Position
type: ExactPosition
position: 684
reference: P11718-1

SIP8670FAEF231F79F2
type: Topological Domain Annotation
comment: Cytoplasmic
range: 22572085585983534tt685tt697

22572085585983534tt685
type: Position
type: ExactPosition
position: 685
reference: P11718-1

22572085585983534tt697
type: Position
type: ExactPosition
position: 697
reference: P11718-1

SIP68E37182AC0E72E0
type: Transmembrane Annotation
comment: Helical; Name=7
range: 22572085585983534tt698tt712

22572085585983534tt698
type: Position
type: ExactPosition
position: 698
reference: P11718-1

22572085585983534tt712
type: Position
type: ExactPosition
position: 712
reference: P11718-1

SIP9C9F860CDCF75149
type: Topological Domain Annotation
comment: Extracellular
range: 22572085585983534tt713tt737

22572085585983534tt713
type: Position
type: ExactPosition
position: 713
reference: P11718-1

22572085585983534tt737
type: Position
type: ExactPosition
position: 737
reference: P11718-1

SIPF737536CDC5EAF99
type: Transmembrane Annotation
comment: Helical; Name=8
range: 22572085585983534tt738tt761

22572085585983534tt738
type: Position
type: ExactPosition
position: 738
reference: P11718-1

22572085585983534tt761
type: Position
type: ExactPosition
position: 761
reference: P11718-1

SIPBF4B2323239FC46B
type: Topological Domain Annotation
comment: Cytoplasmic
range: 22572085585983534tt762tt812

22572085585983534tt762
type: Position
type: ExactPosition
position: 762
reference: P11718-1

22572085585983534tt812
type: Position
type: ExactPosition
position: 812
reference: P11718-1

SIPFF1A522D7E7EB3DC
type: Transmembrane Annotation
comment: Helical; Name=9
range: 22572085585983534tt813tt840

22572085585983534tt813
type: Position
type: ExactPosition
position: 813
reference: P11718-1

22572085585983534tt840
type: Position
type: ExactPosition
position: 840
reference: P11718-1

SIPFC52096A744182AA
type: Topological Domain Annotation
comment: Extracellular
range: 22572085585983534tt841tt868

22572085585983534tt841
type: Position
type: ExactPosition
position: 841
reference: P11718-1

22572085585983534tt868
type: Position
type: ExactPosition
position: 868
reference: P11718-1

SIP75B015A8CF9F6118
type: Transmembrane Annotation
comment: Helical; Name=10
range: 22572085585983534tt869tt887

22572085585983534tt869
type: Position
type: ExactPosition
position: 869
reference: P11718-1

22572085585983534tt887
type: Position
type: ExactPosition
position: 887
reference: P11718-1

SIP9394B668EC0992A0
type: Topological Domain Annotation
comment: Cytoplasmic
range: 22572085585983534tt888tt974

22572085585983534tt888
type: Position
type: ExactPosition
position: 888
reference: P11718-1

SIP40CDBF93C940E46C
type: Region Annotation
comment: Disordered
range: 22572085585983534tt1tt61

22572085585983534tt61
type: Position
type: ExactPosition
position: 61
reference: P11718-1

SIP60F9624A07657CDC
type: Region Annotation
comment: Disordered
range: 22572085585983534tt950tt974

22572085585983534tt950
type: Position
type: ExactPosition
position: 950
reference: P11718-1

SIPC3C7850A109E825C
type: Compositional Bias Annotation
comment: Basic and acidic residues
range: 22572085585983534tt1tt27

22572085585983534tt27
type: Position
type: ExactPosition
position: 27
reference: P11718-1

SIP1E433A31054FC092
type: Active Site Annotation
comment: 4-aspartylphosphate intermediate
range: 22572085585983534tt351tt351

22572085585983534tt351
type: Position
type: ExactPosition
position: 351
reference: P11718-1

22572085585983534tt605
type: Position
type: ExactPosition
position: 605
reference: P11718-1

22572085585983534tt609
type: Position
type: ExactPosition
position: 609
reference: P11718-1

22572085585983534tt714
type: Position
type: ExactPosition
position: 714
reference: P11718-1

P11718-1
type: Simple Sequence
modified: 2002-05-15
version: 2
mass: 107479
value: MSSKKYELDAAAFEDKPESHSDAEMTPQKPQRRQSVLSKAVSEHDERATGPATDLLPPSKGLTTEEAEELLKKYGRNELPEKKTPSWLIYVRGLWGPMPAALWIAIIIEFALENWPDGAILFAIQIANATIGWYETIKAGDAVAALKNSLKPTATVYRDSKWQQIDAAVLVPGDLVKLASGSAVPADCSINEGVIDVDEAALTGESLPVTMGPEHMPKMGSNVVRGEVEGTVQYTGSLTFFGKTAALLQSVESDLGNIHVILRRVMFSLCAISFMLCMCCFIYLLARFYETFRHALQFAVVVLVVSIPIALEIVVTTTLAVGSKHLSKHKIIVTKLSAIEMMSGVNMLCSDKTGTLTLNKMEIQEQCFTFEEGNDLKSTLVLAALAAKWREPPRDALDTMVLGAADLDECDNYQQLNFVPFDPTTKRTAATLVDRRSGEKFDVTKGAPHVILQMVYNQDEINDEVVDIIDSLAARGVRCLSVAKTDQQGRWHMAGILTFLDPPRPDTKDTIRRSKEYGVDVKMITGDHLLIAKEMCRMLDLDPNILTADKLPQIKDANDLPEDLGEKYGDMMLSVGGFAQVFPEHKFMIVETLRQRGYTCAMTGDGVNDAPALKRADVGIAVHGATDAARAAADMVLTEPGLSVVVEAMLVSREVFQRMLSFLTYRISATLQLVCFFFIACFSLTPKAYGSVDPHFQFFHLPVLMFMLITLLNDGCLMTIGYDHVIPSERPQKWNLPVVFVSASILAAVACGSSLMLLWIGLEGYSSQYYENSWFHRLGLAQLPQGKLVTMMYLKISISDFLTLFSSRTGGHFFFYMPPSPILFCGAIISLLVSTMAASFWHKSRPDNVLTEGLAWGQTNAEKLLPLWVWIYCIVWWFVQDVVKVLAHICMDAVDLFGCVSDASGSGPIKPYSDDMKVNGFEPVKKPAEKSTEKALNSSVSSASHKALEGLREDTHSPIEEASPVNVYVSRDQK

http://purl.uniprot.org/uniprot/P11718#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/P11718#attribution-DC036A124EC8E88DF072B29F6D9BB9FE
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/P11718#attribution-D1D66F4BCF034E1CF97E4377E0148090
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/2469011

http://purl.uniprot.org/uniprot/P11718#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

P12522
type: Protein
reviewed: true
created: 1989-10-01
modified: 2023-02-22
version: 134
mnemonic: ATXB_LEIDO
citation: http://purl.uniprot.org/citations/2469011
recommended name: SIP290C4768F974C314
alternative name: SIP2805D21221790562
enzyme: http://purl.uniprot.org/enzyme/7.1.2.1
organism: http://purl.uniprot.org/taxonomy/5661
annotation: SIPCCDFB86EAD08D287
annotation: SIP246BAE6B57E05971
annotation: SIP9E3E2604ADBA8415
annotation: SIP4951D2278F9B5491
annotation: PRO_0000046181
annotation: SIP3B9BB9AC71DC5F23
annotation: SIP3C4CEF7299B4F760
annotation: SIP4E0CC4CC1465526E
annotation: SIP8A5F9C2C2FD8526F
annotation: SIP30C31E0C682FE4A7
annotation: SIP098DD7C8609DB620
annotation: SIP1C188B234D6B839A
annotation: SIPA2D17B094DACF512
annotation: SIP75026FC64E6D98B8
annotation: SIPECFFC1FCF34D0B38
annotation: SIP75081F5B6CC76057
annotation: SIP46A838E8C2DE4C1E
annotation: SIPA6CC2301C22BDB9E
annotation: SIPBAE9F7E06DD1E52B
existence: Evidence at Transcript Level Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/375
classified with: http://purl.uniprot.org/keywords/460
classified with: http://purl.uniprot.org/keywords/597
classified with: http://purl.uniprot.org/keywords/1278
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0016020
classified with: GO_0005524
classified with: GO_0016887
classified with: GO_0008553
classified with: GO_0120029
sequence: P12522-1

P12522-citation-2469011
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: DEVELOPMENTAL STAGE

MHOM/ET/67/L82
type: Strain

SIP290C4768F974C314
type: Structured Name
full name: Probable proton ATPase 1B
ec name: 7.1.2.1

SIP2805D21221790562
type: Structured Name
full name: LdH1B

H1B
type: Gene

SIP9E3E2604ADBA8415
type: Developmental Stage Annotation
comment: More abundant in amastigotes than promastigotes.

SIP4951D2278F9B5491
type: Similarity Annotation
comment: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.

PRO_0000046181
type: Chain Annotation
comment: Probable proton ATPase 1B
mass: 107305
range: 22572089847460398tt1tt974

22572089847460398tt1
type: Position
type: ExactPosition
position: 1
reference: P12522-1

22572089847460398tt974
type: Position
type: ExactPosition
position: 974
reference: P12522-1

SIP3B9BB9AC71DC5F23
type: Transmembrane Annotation
comment: Helical
range: 22572089847460398tt93tt112

22572089847460398tt93
type: Position
type: ExactPosition
position: 93
reference: P12522-1

22572089847460398tt112
type: Position
type: ExactPosition
position: 112
reference: P12522-1

SIP3C4CEF7299B4F760
type: Transmembrane Annotation
comment: Helical
range: 22572089847460398tt118tt137

22572089847460398tt118
type: Position
type: ExactPosition
position: 118
reference: P12522-1

22572089847460398tt137
type: Position
type: ExactPosition
position: 137
reference: P12522-1

SIP4E0CC4CC1465526E
type: Transmembrane Annotation
comment: Helical
range: 22572089847460398tt265tt286

22572089847460398tt265
type: Position
type: ExactPosition
position: 265
reference: P12522-1

22572089847460398tt286
type: Position
type: ExactPosition
position: 286
reference: P12522-1

SIP8A5F9C2C2FD8526F
type: Transmembrane Annotation
comment: Helical
range: 22572089847460398tt295tt321

22572089847460398tt295
type: Position
type: ExactPosition
position: 295
reference: P12522-1

22572089847460398tt321
type: Position
type: ExactPosition
position: 321
reference: P12522-1

SIP30C31E0C682FE4A7
type: Transmembrane Annotation
comment: Helical
range: 22572089847460398tt631tt651

22572089847460398tt631
type: Position
type: ExactPosition
position: 631
reference: P12522-1

22572089847460398tt651
type: Position
type: ExactPosition
position: 651
reference: P12522-1

SIP098DD7C8609DB620
type: Transmembrane Annotation
comment: Helical
range: 22572089847460398tt662tt684

22572089847460398tt662
type: Position
type: ExactPosition
position: 662
reference: P12522-1

22572089847460398tt684
type: Position
type: ExactPosition
position: 684
reference: P12522-1

SIP1C188B234D6B839A
type: Transmembrane Annotation
comment: Helical
range: 22572089847460398tt698tt712

22572089847460398tt698
type: Position
type: ExactPosition
position: 698
reference: P12522-1

22572089847460398tt712
type: Position
type: ExactPosition
position: 712
reference: P12522-1

SIPA2D17B094DACF512
type: Transmembrane Annotation
comment: Helical
range: 22572089847460398tt738tt761

22572089847460398tt738
type: Position
type: ExactPosition
position: 738
reference: P12522-1

22572089847460398tt761
type: Position
type: ExactPosition
position: 761
reference: P12522-1

SIP75026FC64E6D98B8
type: Transmembrane Annotation
comment: Helical
range: 22572089847460398tt813tt840

22572089847460398tt813
type: Position
type: ExactPosition
position: 813
reference: P12522-1

22572089847460398tt840
type: Position
type: ExactPosition
position: 840
reference: P12522-1

SIPECFFC1FCF34D0B38
type: Transmembrane Annotation
comment: Helical
range: 22572089847460398tt869tt887

22572089847460398tt869
type: Position
type: ExactPosition
position: 869
reference: P12522-1

22572089847460398tt887
type: Position
type: ExactPosition
position: 887
reference: P12522-1

SIP75081F5B6CC76057
type: Region Annotation
comment: Disordered
range: 22572089847460398tt1tt61

22572089847460398tt61
type: Position
type: ExactPosition
position: 61
reference: P12522-1

SIP46A838E8C2DE4C1E
type: Region Annotation
comment: Disordered
range: 22572089847460398tt952tt974

22572089847460398tt952
type: Position
type: ExactPosition
position: 952
reference: P12522-1

SIPA6CC2301C22BDB9E
type: Compositional Bias Annotation
comment: Basic and acidic residues
range: 22572089847460398tt1tt27

22572089847460398tt27
type: Position
type: ExactPosition
position: 27
reference: P12522-1

SIPBAE9F7E06DD1E52B
type: Active Site Annotation
comment: 4-aspartylphosphate intermediate
range: 22572089847460398tt351tt351

22572089847460398tt351
type: Position
type: ExactPosition
position: 351
reference: P12522-1

P12522-1
type: Simple Sequence
modified: 1989-10-01
version: 1
mass: 107305
value: MSSKKYELDAAAFEDKPESHSDAEMTPQKPQRRQSVLSKAVSEHDERATGPATDLLPPSKGLTTEEAEELLKKYGRNELPEKKTPSWLIYVRGLWGPMPAALWIAIIIEFALENWPDGAILFAIQIANATIGWYETIKAGDAVAALKNSLKPTATVYRDSKWQQIDAAVLVPGDLVKLASGSAVPADCSINEGVIDVDEAALTGESLPVTMGPEHMPKMGSNVVRGEVEGTVQYTGSLTFFGKTAALLQSVESDLGNIHVILRRVMLALCAISFILCMCCFIYLLARFYETFRHALQFAVVVLVVSIPIALEIVVTTTLAVGSKHLSKHKIIVTKLSAIEMMSGVNMLCSDKTGTLTLNKMEIQEQCFTFEEGNDLKSTLVLAALAAKWREPPRDALDTMVLGAADLDECDNYQQLNFVPFDPTTKRTAATLVDRRSGEKFDVTKGAPHVILQMVYNQDEINDEVVDIIDSLAARGVRCLSVAKTDQQGRWHMAGILTFLDPPRPDTKDTIRRSKEYGVDVKMITGDHLLIAKEMCRMLDLDPNILTADKLPQIKDANDLPEDLGEKYGDMMLSVGGFAQVFPEHKFMIVETLRQRGYTCAMTGDGVNDAPALKRADVGIAVHGATDAARAAADMVLTEPGLSVVVEAMLVSREVFQRMLSFLTYRISATLQLVCFFFIACFSLTPKAYGSVDPNFQFFHLPVLMFMLITLLNDGCLMTIGYDHVIPSERPQKWNLPVVFVSASILAAVACGSSLMLLWIGLEGYSSQYYENSWFHRLGLAQLPQGKLVTMMYLKISISDFLTLFSSRTGGHFFFYVPPSPILFCGAIISLLVSTMAASFWHKSRPDNVLTEGLAWGQTNAEKLLPLWVWIYCIVWWFVQDVVKVLAHICMDAVDLFGCVSDASGSGPIKPYSDDMKVNGFEPVKKPAEKSTEKALNLSVSSGPHKALEGLREDTHVLNESTSPVNAFSPKVKK

http://purl.uniprot.org/uniprot/P12522#attribution-DC036A124EC8E88DF072B29F6D9BB9FE
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/P12522#attribution-D1D66F4BCF034E1CF97E4377E0148090
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/2469011

http://purl.uniprot.org/uniprot/P12522#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

A4H6F7
type: Protein
reviewed: true
created: 2009-05-05
modified: 2023-02-22
version: 80
mnemonic: BOP1_LEIBR
citation: http://purl.uniprot.org/citations/17572675
recommended name: SIP29541BBB9FADD78D
organism: http://purl.uniprot.org/taxonomy/5660
annotation: SIP9A0EAD5BD40D0807
annotation: SIPFAA399A3F5839F7C
annotation: SIPF9A335E1AA644F2B
annotation: PRO_0000370410
annotation: SIPAFEC33C832786957
annotation: SIPA7836FD0579DC448
annotation: SIPD164D5271EF642EC
annotation: SIPA23406BB278DA4A8
annotation: SIP9336E5A096180298
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/539
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/677
classified with: http://purl.uniprot.org/keywords/690
classified with: http://purl.uniprot.org/keywords/698
classified with: http://purl.uniprot.org/keywords/853
classified with: GO_0005730
classified with: GO_0005654
classified with: GO_0030687
classified with: GO_0043021
classified with: GO_0000466
classified with: GO_0000463
sequence: A4H6F7-1
proteome: Chromosome 11

A4H6F7-citation-17572675
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

MHOM/BR/75/M2904
type: Strain

http://purl.uniprot.org/gene3d/2.130.10.10
type: Resource
database: Gene3D
comment: YVTN repeat-like/Quinoprotein amine dehydrogenase
signature sequence match: Gene3D 2.130.10.10 match 1
signature sequence match: Gene3D 2.130.10.10 match 2

MF_03027
type: Resource
database: HAMAP
comment: BOP1
signature sequence match: HAMAP MF 03027 match 1

IPR028598
type: Resource
database: InterPro
comment: BOP1/Erb1

IPR012953
type: Resource
database: InterPro
comment: BOP1_N_dom

IPR015943
type: Resource
database: InterPro
comment: WD40/YVTN_repeat-like_dom_sf

IPR001680
type: Resource
database: InterPro
comment: WD40_repeat

IPR036322
type: Resource
database: InterPro
comment: WD40_repeat_dom_sf

PTHR17605:SF0
type: Resource
database: PANTHER
comment: RIBOSOME BIOGENESIS PROTEIN BOP1
signature sequence match: PANTHER PTHR17605:SF0 match 1

PTHR17605
type: Resource
database: PANTHER
comment: RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN
signature sequence match: PANTHER PTHR17605 match 1

PF08145
type: Resource
database: Pfam
comment: BOP1NT
signature sequence match: Pfam PF08145 match 1

PF00400
type: Resource
database: Pfam
comment: WD40
signature sequence match: Pfam PF00400 match 1
signature sequence match: Pfam PF00400 match 2
signature sequence match: Pfam PF00400 match 3
signature sequence match: Pfam PF00400 match 4
signature sequence match: Pfam PF00400 match 5
signature sequence match: Pfam PF00400 match 6

SM01035
type: Resource
database: SMART
comment: BOP1NT
signature sequence match: SMART SM01035 match 1

SM00320
type: Resource
database: SMART
comment: WD40
signature sequence match: SMART SM00320 match 1
signature sequence match: SMART SM00320 match 2
signature sequence match: SMART SM00320 match 3
signature sequence match: SMART SM00320 match 4
signature sequence match: SMART SM00320 match 5
signature sequence match: SMART SM00320 match 6
signature sequence match: SMART SM00320 match 7

SSF50978
type: Resource
database: SUPFAM
comment: WD40 repeat-like
signature sequence match: SUPFAM SSF50978 match 1
signature sequence match: SUPFAM SSF50978 match 2

PS50082
type: Resource
database: PROSITE
comment: WD_REPEATS_2
signature sequence match: PROSITE PS50082 match 1
signature sequence match: PROSITE PS50082 match 2
signature sequence match: PROSITE PS50082 match 3
signature sequence match: PROSITE PS50082 match 4
signature sequence match: PROSITE PS50082 match 5

PS50294
type: Resource
database: PROSITE
comment: WD_REPEATS_REGION
signature sequence match: PROSITE PS50294 match 1
signature sequence match: PROSITE PS50294 match 2

SIP29541BBB9FADD78D
type: Structured Name
full name: Ribosome biogenesis protein BOP1 homolog

http://purl.uniprot.org/uniprot/A4H6F7#gene-MD53F1D70B198AD728081EE734456CFF09B
type: Gene
orf name: LbrM11_V2.0090
orf name: LbrM_11_0090

SIP9A0EAD5BD40D0807
type: Function Annotation
comment: Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.

SIPF9A335E1AA644F2B
type: Similarity Annotation
comment: Belongs to the WD repeat BOP1/ERB1 family.

PRO_0000370410
type: Chain Annotation
comment: Ribosome biogenesis protein BOP1 homolog
mass: 84316
range: 18353358239053614tt1tt743

18353358239053614tt1
type: Position
type: ExactPosition
position: 1
reference: A4H6F7-1

18353358239053614tt743
type: Position
type: ExactPosition
position: 743
reference: A4H6F7-1

SIPAFEC33C832786957
type: Repeat Annotation
comment: WD 1
range: 18353358239053614tt365tt404

18353358239053614tt365
type: Position
type: ExactPosition
position: 365
reference: A4H6F7-1

18353358239053614tt404
type: Position
type: ExactPosition
position: 404
reference: A4H6F7-1

SIPA7836FD0579DC448
type: Repeat Annotation
comment: WD 2
range: 18353358239053614tt575tt615

18353358239053614tt575
type: Position
type: ExactPosition
position: 575
reference: A4H6F7-1

18353358239053614tt615
type: Position
type: ExactPosition
position: 615
reference: A4H6F7-1

SIPD164D5271EF642EC
type: Repeat Annotation
comment: WD 3
range: 18353358239053614tt617tt655

18353358239053614tt617
type: Position
type: ExactPosition
position: 617
reference: A4H6F7-1

18353358239053614tt655
type: Position
type: ExactPosition
position: 655
reference: A4H6F7-1

SIPA23406BB278DA4A8
type: Repeat Annotation
comment: WD 4
range: 18353358239053614tt659tt701

18353358239053614tt659
type: Position
type: ExactPosition
position: 659
reference: A4H6F7-1

18353358239053614tt701
type: Position
type: ExactPosition
position: 701
reference: A4H6F7-1

SIP9336E5A096180298
type: Repeat Annotation
comment: WD 5
range: 18353358239053614tt712tt743

18353358239053614tt712
type: Position
type: ExactPosition
position: 712
reference: A4H6F7-1

A4H6F7-1
type: Simple Sequence
modified: 2007-05-01
version: 1
mass: 84316
value: MLPGYTAESKDGAHGYERLHDIILQDSDADGEDDVILFPHAEELANAAVGIDGDDGNGRVVRLGTTQHLDESDSSEDEATLNRVGDIPLEWYKDEKHIGYDIEGKKLMKAERSALERLLEATDDPNAMRTIYDALHDEKKTLSNADLQLIFNLQRNRTTNSNYDMYSGVQEDTVVFDPLNHPLARSSGPSKKAFVPALHDTKVIAKMVRRLRKEEAESKLRPATEEKEDEDQLLWDDGHVEMDTHTHFKYFNRVPKPKVPPPGTFESYRPPPEYLPSERAKQRQARLRTIDRREHFLPQSFDALRHVPFYHHTIQDRYQRCLDLAFFPRAQRTRLVVDPDKLLPELPNPKDLRPYPEKLSFHYKGHTATVRSVSVSPNGQYLATGCDDHLVRVYEVQTGRLMKRYDMGAPVQQVEFCPSKSLNILAAAVEYSLVFVVPTFAAHALVNDHTIRFLRAPGLSAGQREAAHALGAVDTLGGRAVTQTTLDADETAHEATTDLHDVEEREKRAEFLDASAKERNAGIVVKIAMHAKVKKFCFHIKGDYLCALCPKDHVKYRQTIMLQLSKRKVFCPFRKFSEVVTDCRFHPREPLFFLATTNSVRCYNLMAHRLQRRFKASGGVTTCLSIHPEGDNFLVGDTTSHTSWFDMDFSDKPYKRMRSHKGVVNALAFHPKTGAYPLFATGASDGQVHVFHGMVYDDYNKNALVVPVKILKHQRSVYAVAWHPSLAWLFTSTEDGVVTAWTE

http://purl.uniprot.org/uniprot/A4H6F7#attribution-8F2859D8305D15330898A6B8F18233F0
manual: true
evidence: ECO_0000255
source: MF_03027

A4HUV2
type: Protein
reviewed: true
created: 2009-05-05
modified: 2023-02-22
version: 77
mnemonic: BOP1_LEIIN
citation: http://purl.uniprot.org/citations/17572675
recommended name: SIP29541BBB9FADD78D
organism: http://purl.uniprot.org/taxonomy/5671
annotation: SIP10F4317708ABC656
annotation: SIPDF3ADBA7D0D77BFE
annotation: SIP4BB16A25ED6D9A2E
annotation: PRO_0000370411
annotation: SIP5D52F3CA7432B180
annotation: SIP718EA9E47DD81A16
annotation: SIPCD43CBC1721A0007
annotation: SIP7F42CB92922596F2
annotation: SIP42E1756E25C88F3D
annotation: SIPAF90511F91FD8C26
annotation: SIPFAE34921E2F14896
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/539
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/677
classified with: http://purl.uniprot.org/keywords/690
classified with: http://purl.uniprot.org/keywords/698
classified with: http://purl.uniprot.org/keywords/853
classified with: GO_0005730
classified with: GO_0005654
classified with: GO_0030687
classified with: GO_0043021
classified with: GO_0000466
classified with: GO_0000463
sequence: A4HUV2-1
proteome: Chromosome 11

A4HUV2-citation-17572675
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

JPCM5
type: Strain

KOG0650
type: Resource
database: eggNOG
comment: Eukaryota

SIP29541BBB9FADD78D
type: Structured Name
full name: Ribosome biogenesis protein BOP1 homolog

http://purl.uniprot.org/uniprot/A4HUV2#gene-MD5C75E38B8D8A10B55EFD66486A34A6B7E
type: Gene
orf name: LinJ11.0410
orf name: LinJ_11_0410

SIP10F4317708ABC656
type: Function Annotation
comment: Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.

SIP4BB16A25ED6D9A2E
type: Similarity Annotation
comment: Belongs to the WD repeat BOP1/ERB1 family.

PRO_0000370411
type: Chain Annotation
comment: Ribosome biogenesis protein BOP1 homolog
mass: 91356
range: 18353358760194606tt1tt808

18353358760194606tt1
type: Position
type: ExactPosition
position: 1
reference: A4HUV2-1

18353358760194606tt808
type: Position
type: ExactPosition
position: 808
reference: A4HUV2-1

SIP5D52F3CA7432B180
type: Repeat Annotation
comment: WD 1
range: 18353358760194606tt430tt469

18353358760194606tt430
type: Position
type: ExactPosition
position: 430
reference: A4HUV2-1

18353358760194606tt469
type: Position
type: ExactPosition
position: 469
reference: A4HUV2-1

SIP718EA9E47DD81A16
type: Repeat Annotation
comment: WD 2
range: 18353358760194606tt640tt680

18353358760194606tt640
type: Position
type: ExactPosition
position: 640
reference: A4HUV2-1

18353358760194606tt680
type: Position
type: ExactPosition
position: 680
reference: A4HUV2-1

SIPCD43CBC1721A0007
type: Repeat Annotation
comment: WD 3
range: 18353358760194606tt682tt720

18353358760194606tt682
type: Position
type: ExactPosition
position: 682
reference: A4HUV2-1

18353358760194606tt720
type: Position
type: ExactPosition
position: 720
reference: A4HUV2-1

SIP7F42CB92922596F2
type: Repeat Annotation
comment: WD 4
range: 18353358760194606tt724tt766

18353358760194606tt724
type: Position
type: ExactPosition
position: 724
reference: A4HUV2-1

18353358760194606tt766
type: Position
type: ExactPosition
position: 766
reference: A4HUV2-1

SIP42E1756E25C88F3D
type: Repeat Annotation
comment: WD 5
range: 18353358760194606tt777tt808

18353358760194606tt777
type: Position
type: ExactPosition
position: 777
reference: A4HUV2-1

SIPAF90511F91FD8C26
type: Region Annotation
comment: Disordered
range: 18353358760194606tt1tt56

18353358760194606tt56
type: Position
type: ExactPosition
position: 56
reference: A4HUV2-1

SIPFAE34921E2F14896
type: Compositional Bias Annotation
comment: Polar residues
range: 18353358760194606tt19tt54

18353358760194606tt19
type: Position
type: ExactPosition
position: 19
reference: A4HUV2-1

18353358760194606tt54
type: Position
type: ExactPosition
position: 54
reference: A4HUV2-1

A4HUV2-1
type: Simple Sequence
modified: 2007-05-01
version: 1
mass: 91356
value: MTSPKGKPSPKRSAPAPTTAALTPRTEERTEGATSSASASASSHISSSFDSPRDDTVVFTGYTAESKHNAHGYERLHDIILQDGDTGADSEDGRANEDNVILFPHAEELANAAAGINGDDDNGRVVRLGTIQHLEESDSSEDEPTLNRVGDIPLEWYKDEDHIGYDIEGKKLMKKERSALERLLEATDDPNAMRTIYDALHDEKKTLSNADLQLIFNLQRNRTTNPNYDMYSEVQEDTVVFDPLNHPLARSGGPSKRAFVPALHDMKVIAKMVRRLRKEEAERKLRPGKEEKEEEDQLLWDDGHVEMDTHTHFKYFNRVPKPKLPPPGTFESYRPPPEYLPSERAKQRQARLRAIDRKEHFLPQSFDALRHVPFYHHTIQDRYQRCLDLAFFPRAQRTRLVVDPDKLLPELPDPKDLRPYPEKLSFHYKGHTATVRSVSVSPNGQYLATGCDDHLVRVFEVQTGRLMKRYDMGAPVQQVEFCPSTSLNILAAAVEYSLVFIVPTFAAHTLVNDHTIRFLRAPGLSAGQREAAHALGAVDTLGGRAVTQTTLDADETAHEATADLHDIEEREKRAEFVDASAKERNAGIVVKIAMHAKVKKFCFHIKGDYLCALCPKDHVKYRQTIMLQLSKRKVFCPFRKFSEVVTDCRFHPREPIFFLATTNSVRCYNLMAHRLQRRFKASGGVTTCLSIHPEGDNFLVGDTTSHTSWFDMDFSDKPYKRMRSHRGVVNALAFHPKTNAYPLFATGASDGQVHVFHGMVYDDYNKNALVVPVKILKHQRPVYAVAWHPTLAWLFTSTEDGVVTAWTE

http://purl.uniprot.org/uniprot/A4HUV2#attribution-8F2859D8305D15330898A6B8F18233F0
manual: true
evidence: ECO_0000255
source: MF_03027

Q4QH39
type: Protein
reviewed: true
created: 2009-05-05
modified: 2023-02-22
version: 101
mnemonic: BOP1_LEIMA
citation: http://purl.uniprot.org/citations/16020728
recommended name: SIP29541BBB9FADD78D
organism: http://purl.uniprot.org/taxonomy/5664
annotation: SIPAC2A8DDC36D53DA6
annotation: SIPB018B3201D189C14
annotation: SIP183E69B91E275C84
annotation: PRO_0000370412
annotation: SIP463DC3E3D1D66423
annotation: SIP9521B0D94345D0CE
annotation: SIPBA0FFF810D8A8F2D
annotation: SIP54BAC79F7A151DE7
annotation: SIP7A3B3D6B992FF550
annotation: SIP4E3808C39F924EFB
annotation: SIP0B1BC21FC5B94F5C
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/539
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/677
classified with: http://purl.uniprot.org/keywords/690
classified with: http://purl.uniprot.org/keywords/698
classified with: http://purl.uniprot.org/keywords/853
classified with: GO_0005730
classified with: GO_0005654
classified with: GO_0070545
classified with: GO_0030687
classified with: GO_0043021
classified with: GO_0000466
classified with: GO_0000463
sequence: Q4QH39-1
proteome: Chromosome 11

Q4QH39-citation-16020728
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

MHOM/IL/81/Friedlin
type: Strain

SIP29541BBB9FADD78D
type: Structured Name
full name: Ribosome biogenesis protein BOP1 homolog

http://purl.uniprot.org/uniprot/Q4QH39#gene-MD544FCFD333778DA8D306DE6AEAF2B28A8
type: Gene
orf name: LmjF11.0410
orf name: LmjF_11_0410

SIPAC2A8DDC36D53DA6
type: Function Annotation
comment: Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.

SIP183E69B91E275C84
type: Similarity Annotation
comment: Belongs to the WD repeat BOP1/ERB1 family.

PRO_0000370412
type: Chain Annotation
comment: Ribosome biogenesis protein BOP1 homolog
mass: 91191
range: 22856996821874990tt1tt808

22856996821874990tt1
type: Position
type: ExactPosition
position: 1
reference: Q4QH39-1

22856996821874990tt808
type: Position
type: ExactPosition
position: 808
reference: Q4QH39-1

SIP463DC3E3D1D66423
type: Repeat Annotation
comment: WD 1
range: 22856996821874990tt430tt469

22856996821874990tt430
type: Position
type: ExactPosition
position: 430
reference: Q4QH39-1

22856996821874990tt469
type: Position
type: ExactPosition
position: 469
reference: Q4QH39-1

SIP9521B0D94345D0CE
type: Repeat Annotation
comment: WD 2
range: 22856996821874990tt640tt680

22856996821874990tt640
type: Position
type: ExactPosition
position: 640
reference: Q4QH39-1

22856996821874990tt680
type: Position
type: ExactPosition
position: 680
reference: Q4QH39-1

SIPBA0FFF810D8A8F2D
type: Repeat Annotation
comment: WD 3
range: 22856996821874990tt682tt720

22856996821874990tt682
type: Position
type: ExactPosition
position: 682
reference: Q4QH39-1

22856996821874990tt720
type: Position
type: ExactPosition
position: 720
reference: Q4QH39-1

SIP54BAC79F7A151DE7
type: Repeat Annotation
comment: WD 4
range: 22856996821874990tt724tt766

22856996821874990tt724
type: Position
type: ExactPosition
position: 724
reference: Q4QH39-1

22856996821874990tt766
type: Position
type: ExactPosition
position: 766
reference: Q4QH39-1

SIP7A3B3D6B992FF550
type: Repeat Annotation
comment: WD 5
range: 22856996821874990tt777tt808

22856996821874990tt777
type: Position
type: ExactPosition
position: 777
reference: Q4QH39-1

SIP4E3808C39F924EFB
type: Region Annotation
comment: Disordered
range: 22856996821874990tt1tt55

22856996821874990tt55
type: Position
type: ExactPosition
position: 55
reference: Q4QH39-1

SIP0B1BC21FC5B94F5C
type: Compositional Bias Annotation
comment: Polar residues
range: 22856996821874990tt29tt54

22856996821874990tt29
type: Position
type: ExactPosition
position: 29
reference: Q4QH39-1

22856996821874990tt54
type: Position
type: ExactPosition
position: 54
reference: Q4QH39-1

Q4QH39-1
type: Simple Sequence
modified: 2005-07-19
version: 1
mass: 91191
value: MTSPKGKPSPKRSAPAPATAALTPCAEERTEGATSSASASASSHISSSFDSPRDDTVVLTGYTAESEHSAHGYERLHDIILQGSDTDADSEDGRANEDDVILFPHAEELSNAAAGVGGDDDNGRVVRLGTTQHLDESDSSEDEPTLNRVGDIPLEWYKDEDHIGYDIEGKKLMKKERSALERLLEATDDPNAMRTIYDALHDEKKTLSNADLQLIFNLQRNRTTNPNYDMYSEVQEDTVVFDPLNHPLARSGGPSKKAFVPALHDMKVIAKMVRRLRKEEAERRLRPAKEEKEEEDQLLWDDSHVEMDTHTHFKYFNRIPKPKLPPPGTFESYRPPPEYLPSERAKQRQARLRTIDRKEHFLPQSFDALRHVPFYHHTIQDRYQRCLDLAFFPRAQRTRLVVDPDKLLPELPDPKDLRPYPEKLSFHYKGHTATVRSVSVSPNGQYLATGCDDHLVRVFEVQTGRLMKRYDMGAPVQQVEFCPSTSLNILAVAVEYSLVFIVPTFAAHTLVNDHTIRFLRAPGLSAGQREAAHALGAVDTLGGRAVTQTALDADETAHEATADLHDIEEREKRAEFVDASAKERNAGIVVKIAMHAKVKKFCFHIKGDYLCALCPKDHVKYRQTIMLQLSKRKVFCPFRKFSEVVTDCRFHPREPIFFLATTNSVRCYNLMAHRLQRRFKASGGVTTCLSIHPEGDNFLVGDTTSHTSWFDMDFSDKPYKRMRSHKGVVNALAFHPKTNAYPLFATGASDGQVHVFHGMVYDDYNKNALVVPVKILKHQRPVYAVAWHPTLAWLFTSTEDGVVTAWTE

http://purl.uniprot.org/uniprot/Q4QH39#attribution-0805D343A25D9F44C91CBB2C5680EC43
creator: GeneDB
manual: true
evidence: ECO_0000266

http://purl.uniprot.org/uniprot/Q4QH39#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/Q4QH39#attribution-8F2859D8305D15330898A6B8F18233F0
manual: true
evidence: ECO_0000255
source: MF_03027

P12865
type: Protein
reviewed: true
created: 1989-10-01
modified: 2023-02-22
version: 106
mnemonic: BS2_TRYBB
old mnemonic: BS2_TRYBR
citation: http://purl.uniprot.org/citations/2551375
recommended name: SIPE193A2E469933760
organism: http://purl.uniprot.org/taxonomy/5702
annotation: SIPE93AFA5C1C643D2F
annotation: SIP0D035A9C9A5F1479
annotation: PRO_0000034246
annotation: SIPD473EB31285229E8
annotation: SIP3EDABDC0D828E28F
annotation: SIPEE740845F2790F66
annotation: SIP0D46A1AE26D6B787
annotation: SIP5997D8C663461496
annotation: SIP77C14BD505F2288D
annotation: SIP44441F6550BDEFB1
annotation: SIP13AABDDC313F08FA
annotation: SIP55BEEF0960825BE0
annotation: SIP6CD9603627112E72
annotation: SIPFFDC076C64214CF5
annotation: SIP7007D70FEA36150C
annotation: SIP3D4263E6D9C468DA
annotation: SIP00A526B7DB9E8533
annotation: SIP4F104153951FAEE7
annotation: SIPBC69E3252B917AD8
annotation: SIPEFE031AF877C9354
annotation: SIPE6527B830D535D7D
annotation: SIPC8EAD47AD7C9E693
annotation: SIP7AD704BBE6583A2E
annotation: SIP3E43D2616D5B3D82
annotation: SIP1FD5CE1C90B56FE1
annotation: SIPB01E485F78F0B88C
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/1015
classified with: http://purl.uniprot.org/keywords/325
classified with: http://purl.uniprot.org/keywords/413
classified with: http://purl.uniprot.org/keywords/676
classified with: http://purl.uniprot.org/keywords/677
classified with: http://purl.uniprot.org/keywords/732
classified with: GO_0003756
sequence: P12865-1

P12865-citation-2551375
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

P12865
type: Resource
database: GlyCosmos
comment: 13 sites, No reported glycans

http://purl.uniprot.org/brenda/5.3.4.1
type: Resource
database: BRENDA
comment: 6519

cd02961
type: Resource
database: CDD
comment: PDI_a_family
signature sequence match: CDD cd02961 match 1

cd02995
type: Resource
database: CDD
comment: PDI_a_PDI_a'_C
signature sequence match: CDD cd02995 match 1

cd02982
type: Resource
database: CDD
comment: PDI_b'_family
signature sequence match: CDD cd02982 match 1

cd02981
type: Resource
database: CDD
comment: PDI_b_family
signature sequence match: CDD cd02981 match 1

http://purl.uniprot.org/gene3d/3.40.30.10
type: Resource
database: Gene3D
comment: Glutaredoxin
signature sequence match: Gene3D 3.40.30.10 match 1
signature sequence match: Gene3D 3.40.30.10 match 2
signature sequence match: Gene3D 3.40.30.10 match 3
signature sequence match: Gene3D 3.40.30.10 match 4

IPR005788
type: Resource
database: InterPro
comment: Disulphide_isomerase

IPR036249
type: Resource
database: InterPro
comment: Thioredoxin-like_sf

IPR017937
type: Resource
database: InterPro
comment: Thioredoxin_CS

IPR013766
type: Resource
database: InterPro
comment: Thioredoxin_domain

PTHR18929
type: Resource
database: PANTHER
comment: PROTEIN DISULFIDE ISOMERASE
signature sequence match: PANTHER PTHR18929 match 1

PTHR18929:SF132
type: Resource
database: PANTHER
comment: PROTEIN DISULFIDE-ISOMERASE A3
signature sequence match: PANTHER PTHR18929:SF132 match 1

PF00085
type: Resource
database: Pfam
comment: Thioredoxin
signature sequence match: Pfam PF00085 match 1
signature sequence match: Pfam PF00085 match 2

PF13848
type: Resource
database: Pfam
comment: Thioredoxin_6
signature sequence match: Pfam PF13848 match 1

SSF52833
type: Resource
database: SUPFAM
comment: Thioredoxin-like
signature sequence match: SUPFAM SSF52833 match 1
signature sequence match: SUPFAM SSF52833 match 2
signature sequence match: SUPFAM SSF52833 match 3
signature sequence match: SUPFAM SSF52833 match 4

TIGR01126
type: Resource
database: TIGRFAMs
comment: pdi_dom
signature sequence match: TIGRFAMs TIGR01126 match 1

PS00194
type: Resource
database: PROSITE
comment: THIOREDOXIN_1
signature sequence match: PROSITE PS00194 match 1
signature sequence match: PROSITE PS00194 match 2

PS51352
type: Resource
database: PROSITE
comment: THIOREDOXIN_2
signature sequence match: PROSITE PS51352 match 1
signature sequence match: PROSITE PS51352 match 2

SIPE193A2E469933760
type: Structured Name
full name: Bloodstream-specific protein 2

BS2
type: Gene

SIPE93AFA5C1C643D2F
type: Similarity Annotation
comment: Belongs to the protein disulfide isomerase family.

22572089898054958tt1
type: Position
type: ExactPosition
position: 1
reference: P12865-1

22572089898054958tt14
type: Position
type: ExactPosition
position: 14
reference: P12865-1

PRO_0000034246
type: Chain Annotation
comment: Bloodstream-specific protein 2
mass: 54076
range: 22572089898054958tt15tt497

22572089898054958tt15
type: Position
type: ExactPosition
position: 15
reference: P12865-1

22572089898054958tt497
type: Position
type: ExactPosition
position: 497
reference: P12865-1

SIPD473EB31285229E8
type: Domain Extent Annotation
comment: Thioredoxin 1
range: 22572089898054958tt15tt124

22572089898054958tt124
type: Position
type: ExactPosition
position: 124
reference: P12865-1

SIP3EDABDC0D828E28F
type: Domain Extent Annotation
comment: Thioredoxin 2
range: 22572089898054958tt334tt455

22572089898054958tt334
type: Position
type: ExactPosition
position: 334
reference: P12865-1

22572089898054958tt455
type: Position
type: ExactPosition
position: 455
reference: P12865-1

SIPEE740845F2790F66
type: Region Annotation
comment: Disordered
range: 22572089898054958tt461tt497

22572089898054958tt461
type: Position
type: ExactPosition
position: 461
reference: P12865-1

SIP0D46A1AE26D6B787
type: Active Site Annotation
comment: Nucleophile
range: 22572089898054958tt378tt378

22572089898054958tt378
type: Position
type: ExactPosition
position: 378
reference: P12865-1

SIP5997D8C663461496
type: Active Site Annotation
comment: Nucleophile
range: 22572089898054958tt381tt381

22572089898054958tt381
type: Position
type: ExactPosition
position: 381
reference: P12865-1

SIP77C14BD505F2288D
type: Site Annotation
comment: Contributes to redox potential value
range: 22572089898054958tt379tt379

22572089898054958tt379
type: Position
type: ExactPosition
position: 379
reference: P12865-1

SIP44441F6550BDEFB1
type: Site Annotation
comment: Contributes to redox potential value
range: 22572089898054958tt380tt380

22572089898054958tt380
type: Position
type: ExactPosition
position: 380
reference: P12865-1

SIP13AABDDC313F08FA
type: Site Annotation
comment: Lowers pKa of C-terminal Cys of second active site
range: 22572089898054958tt441tt441

22572089898054958tt441
type: Position
type: ExactPosition
position: 441
reference: P12865-1