A0A0D2UG83
type: Protein
reviewed: true
created: 2022-10-12
modified: 2023-02-22
version: 38
mnemonic: H2AY_CAPO3
citation: SIPA568365E1C5B7653
citation: http://purl.uniprot.org/citations/34887560
recommended name: SIPF68A4BB0C7AB557A
organism: http://purl.uniprot.org/taxonomy/595528
annotation: SIPE831A50FABD3FF8C
annotation: SIPFA7BCF877AA551CF
annotation: SIPAE5421A85F62836E
annotation: SIP65B5DC56D84ED7FC
annotation: SIP84C53DDB39E2868E
annotation: SIP954BBEE036E3EF1A
annotation: SIP9AB67B000E97D764
annotation: PRO_0000456369
annotation: SIPBB0CD03E5F1D2F84
annotation: SIPD37500F89C3E0032
annotation: SIP0B07804AB984D80C
annotation: SIPA20DF952D6062D9B
annotation: SIP62A542AF24FB8365
annotation: SIP1C68E84AE3DDC463
annotation: SIP0CCEA31D778D3E5D
annotation: SIP3E89F06D53D878EC
annotation: SIPD769B4A2779678D2
annotation: SIPFD05C9622B846E11
annotation: SIPBDA4BC105759D017
annotation: SIP0CD468E428F955F0
annotation: SIPA16FE89D850C5079
annotation: SIP4A8727C6B5F295AE
annotation: SIP78E744A4D5D602A4
annotation: SIPDE87A9592E86831E
annotation: SIP6498348BEC0A2CD1
annotation: SIP7888EEBFF3FCA2F6
annotation: SIPB756710349273D81
annotation: SIP4B356D52892EF400
annotation: SIPF3277928CB055CA3
annotation: SIPC2FCAB1BBB22CAED
annotation: SIPF08B62A642150C90
annotation: SIPAFCE99B6727A19BB
annotation: SIP71A94105B4DEBFEA
annotation: SIP5A517D269F4578FE
annotation: SIPA36BF59716CAA759
annotation: SIPFE5C188B998DC638
annotation: SIPB82698DF0EA176A9
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/156
classified with: http://purl.uniprot.org/keywords/544
classified with: http://purl.uniprot.org/keywords/539
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0000786
classified with: GO_0005634
classified with: GO_0072570
classified with: GO_0160002
classified with: GO_0003677
classified with: GO_0046982
classified with: GO_0030527
classified with: GO_0006325
classified with: GO_0010836
classified with: GO_1902688
sequence: A0A0D2UG83-1
proteome: Unassembled WGS sequence

SIPA568365E1C5B7653
type: Submission Citation
title: The Genome Sequence of Capsaspora owczarzaki ATCC 30864.
author: Russ C.
author: Cuomo C.
author: Burger G.
author: Gray M.W.
author: Holland P.W.H.
author: King N.
author: Lang F.B.F.
author: Roger A.J.
author: Ruiz-Trillo I.
author: Young S.K.
author: Zeng Q.
author: Gargeya S.
author: Alvarado L.
author: Berlin A.
author: Chapman S.B.
author: Chen Z.
author: Freedman E.
author: Gellesch M.
author: Goldberg J.
author: Griggs A.
author: Gujja S.
author: Heilman E.
author: Heiman D.
author: Howarth C.
author: Mehta T.
author: Neiman D.
author: Pearson M.
author: Roberts A.
author: Saif S.
author: Shea T.
author: Shenoy N.
author: Sisk P.
author: Stolte C.
author: Sykes S.
author: White J.
author: Yandava C.
author: Haas B.
author: Nusbaum C.
author: Birren B.
date: 2011-02
submitted to: EMBL/GenBank/DDBJ

…
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 30864
type: Strain

A0A0D2UG83-citation-34887560
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (1.34 ANGSTROMS) OF 182-368 IN COMPLEX WITH ADP-D-RIBOSE
scope: FUNCTION
scope: DOMAIN
scope: DEVELOPMENTAL STAGE
scope: MUTAGENESIS OF GLN-225 AND ASN-316

7NY6
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 1.34
chain sequence mapping: PDB 7NY6 tt182tt368

PDB 7NY6 tt182tt368
chain: A=182-368

7NY7
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.00
chain sequence mapping: PDB 7NY7 tt182tt368

PDB 7NY7 tt182tt368
chain: A=182-368

KOG1756
type: Resource
database: eggNOG
comment: Eukaryota

KOG2633
type: Resource
database: eggNOG
comment: Eukaryota

cd00074
type: Resource
database: CDD
comment: H2A
signature sequence match: CDD cd00074 match 1

http://purl.uniprot.org/gene3d/1.10.20.10
type: Resource
database: Gene3D
comment: Histone, subunit A
signature sequence match: Gene3D 1.10.20.10 match 1

http://purl.uniprot.org/gene3d/3.40.220.10
type: Resource
database: Gene3D
comment: Leucine Aminopeptidase, subunit E, domain 1
signature sequence match: Gene3D 3.40.220.10 match 1

IPR009072
type: Resource
database: InterPro
comment: Histone-fold

IPR002119
type: Resource
database: InterPro
comment: Histone_H2A

IPR007125
type: Resource
database: InterPro
comment: Histone_H2A/H2B/H3

IPR032454
type: Resource
database: InterPro
comment: Histone_H2A_C

IPR032458
type: Resource
database: InterPro
comment: Histone_H2A_CS

IPR002589
type: Resource
database: InterPro
comment: Macro_dom

IPR043472
type: Resource
database: InterPro
comment: Macro_dom-like

PTHR23430
type: Resource
database: PANTHER
comment: HISTONE H2A
signature sequence match: PANTHER PTHR23430 match 1

PTHR23430:SF50
type: Resource
database: PANTHER
comment: HISTONE H2A.1-RELATED
signature sequence match: PANTHER PTHR23430:SF50 match 1

PF00125
type: Resource
database: Pfam
comment: Histone
signature sequence match: Pfam PF00125 match 1

PF16211
type: Resource
database: Pfam
comment: Histone_H2A_C
signature sequence match: Pfam PF16211 match 1

PF01661
type: Resource
database: Pfam
comment: Macro
signature sequence match: Pfam PF01661 match 1

PR00620
type: Resource
database: PRINTS
comment: HISTONEH2A

SM00506
type: Resource
database: SMART
comment: A1pp
signature sequence match: SMART SM00506 match 1

SM00414
type: Resource
database: SMART
comment: H2A
signature sequence match: SMART SM00414 match 1

SSF47113
type: Resource
database: SUPFAM
comment: Histone-fold
signature sequence match: SUPFAM SSF47113 match 1

SSF52949
type: Resource
database: SUPFAM
comment: Macro domain-like
signature sequence match: SUPFAM SSF52949 match 1

PS00046
type: Resource
database: PROSITE
comment: HISTONE_H2A
signature sequence match: PROSITE PS00046 match 1

PS51154
type: Resource
database: PROSITE
comment: MACRO
signature sequence match: PROSITE PS51154 match 1

SIPF68A4BB0C7AB557A
type: Structured Name
full name: Histone macroH2A1.1

http://purl.uniprot.org/uniprot/A0A0D2UG83#gene-MD56F420C49F10E0953DEA6DC9621E37E10
type: Gene
orf name: CAOG_004778

SIPE831A50FABD3FF8C
type: Function Annotation
comment: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

SIPFA7BCF877AA551CF
type: Function Annotation
comment: Specifically binds poly-ADP-ribose and plays a key role in NAD(+) metabolism (PubMed:34887560). Able to bind to the ends of poly-ADP-ribose chains created by PARP1 and cap them (PubMed:34887560). This prevents PARP1 from further addition of ADP-ribose and thus limits the consumption of nuclear NAD(+), allowing the cell to maintain proper NAD(+) levels in both the nucleus and the mitochondria to promote proper mitochondrial respiration (PubMed:34887560).

SIPAE5421A85F62836E
type: Subunit Annotation
comment: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.

SIP84C53DDB39E2868E
type: Developmental Stage Annotation
comment: Highly expressed during the cystic life stage.

SIP954BBEE036E3EF1A
type: Domain Annotation
comment: The macro domain specifically binds poly-ADP-ribose (PubMed:34887560). Binds poly-ADP-ribose with much higher affinity compared to vertebrate macroH2A1.1 orthologs (PubMed:34887560).

SIP9AB67B000E97D764
type: Similarity Annotation
comment: Belongs to the histone H2A family.

PRO_0000456369
type: Chain Annotation
comment: Histone macroH2A1.1
mass: 38580
range: -9218585576763945938tt1tt368

-9218585576763945938tt1
type: Position
type: ExactPosition
position: 1
reference: A0A0D2UG83-1

-9218585576763945938tt368
type: Position
type: ExactPosition
position: 368
reference: A0A0D2UG83-1

SIPBB0CD03E5F1D2F84
type: Domain Extent Annotation
comment: Macro
range: -9218585576763945938tt184tt368

-9218585576763945938tt184
type: Position
type: ExactPosition
position: 184
reference: A0A0D2UG83-1

SIPD37500F89C3E0032
type: Region Annotation
comment: Disordered
range: -9218585576763945938tt154tt177

-9218585576763945938tt154
type: Position
type: ExactPosition
position: 154
reference: A0A0D2UG83-1

-9218585576763945938tt177
type: Position
type: ExactPosition
position: 177
reference: A0A0D2UG83-1

-9218585576763945938tt203
type: Position
type: ExactPosition
position: 203
reference: A0A0D2UG83-1

-9218585576763945938tt204
type: Position
type: ExactPosition
position: 204
reference: A0A0D2UG83-1

-9218585576763945938tt225
type: Position
type: ExactPosition
position: 225
reference: A0A0D2UG83-1

-9218585576763945938tt226
type: Position
type: ExactPosition
position: 226
reference: A0A0D2UG83-1

-9218585576763945938tt275
type: Position
type: ExactPosition
position: 275
reference: A0A0D2UG83-1

-9218585576763945938tt313
type: Position
type: ExactPosition
position: 313
reference: A0A0D2UG83-1

-9218585576763945938tt314
type: Position
type: ExactPosition
position: 314
reference: A0A0D2UG83-1

-9218585576763945938tt315
type: Position
type: ExactPosition
position: 315
reference: A0A0D2UG83-1

-9218585576763945938tt316
type: Position
type: ExactPosition
position: 316
reference: A0A0D2UG83-1

-9218585576763945938tt317
type: Position
type: ExactPosition
position: 317
reference: A0A0D2UG83-1

SIPA16FE89D850C5079
type: Mutagenesis Annotation
comment: Reduced affinity for poly-ADP-ribose.
substitution: E
range: -9218585576763945938tt225tt225

SIP4A8727C6B5F295AE
type: Mutagenesis Annotation
comment: Reduced affinity for poly-ADP-ribose.
substitution: R
range: -9218585576763945938tt316tt316

-9218585576763945938tt190
type: Position
type: ExactPosition
position: 190
reference: A0A0D2UG83-1

-9218585576763945938tt196
type: Position
type: ExactPosition
position: 196
reference: A0A0D2UG83-1

-9218585576763945938tt202
type: Position
type: ExactPosition
position: 202
reference: A0A0D2UG83-1

-9218585576763945938tt206
type: Position
type: ExactPosition
position: 206
reference: A0A0D2UG83-1

-9218585576763945938tt209
type: Position
type: ExactPosition
position: 209
reference: A0A0D2UG83-1

-9218585576763945938tt216
type: Position
type: ExactPosition
position: 216
reference: A0A0D2UG83-1

-9218585576763945938tt224
type: Position
type: ExactPosition
position: 224
reference: A0A0D2UG83-1

-9218585576763945938tt234
type: Position
type: ExactPosition
position: 234
reference: A0A0D2UG83-1

-9218585576763945938tt237
type: Position
type: ExactPosition
position: 237
reference: A0A0D2UG83-1

-9218585576763945938tt249
type: Position
type: ExactPosition
position: 249
reference: A0A0D2UG83-1

-9218585576763945938tt257
type: Position
type: ExactPosition
position: 257
reference: A0A0D2UG83-1

-9218585576763945938tt261
type: Position
type: ExactPosition
position: 261
reference: A0A0D2UG83-1

-9218585576763945938tt265
type: Position
type: ExactPosition
position: 265
reference: A0A0D2UG83-1

-9218585576763945938tt274
type: Position
type: ExactPosition
position: 274
reference: A0A0D2UG83-1

-9218585576763945938tt283
type: Position
type: ExactPosition
position: 283
reference: A0A0D2UG83-1

-9218585576763945938tt301
type: Position
type: ExactPosition
position: 301
reference: A0A0D2UG83-1

-9218585576763945938tt306
type: Position
type: ExactPosition
position: 306
reference: A0A0D2UG83-1

-9218585576763945938tt309
type: Position
type: ExactPosition
position: 309
reference: A0A0D2UG83-1

-9218585576763945938tt321
type: Position
type: ExactPosition
position: 321
reference: A0A0D2UG83-1

-9218585576763945938tt336
type: Position
type: ExactPosition
position: 336
reference: A0A0D2UG83-1

-9218585576763945938tt338
type: Position
type: ExactPosition
position: 338
reference: A0A0D2UG83-1

-9218585576763945938tt340
type: Position
type: ExactPosition
position: 340
reference: A0A0D2UG83-1

-9218585576763945938tt346
type: Position
type: ExactPosition
position: 346
reference: A0A0D2UG83-1

-9218585576763945938tt353
type: Position
type: ExactPosition
position: 353
reference: A0A0D2UG83-1

-9218585576763945938tt354
type: Position
type: ExactPosition
position: 354
reference: A0A0D2UG83-1

-9218585576763945938tt365
type: Position
type: ExactPosition
position: 365
reference: A0A0D2UG83-1

A0A0D2UG83-1
type: Simple Sequence
modified: 2015-04-29
version: 1
mass: 38580
value: MAKSKKIVAATSGSRSRSSRAGLAFPVGRVHRLLRKGHFADRIGSGSAVYLAAVLEYLTAEILELAGNAARDNRKTRINPRHIQLAVRNDEELSKLFTGVVIPSGGTLPHIWPALIPNEAKDSSTASASFNAPAKSATVKALAAAKSAGKKPAAVSSSSAAASSSSSASSSSSVAPKKPVRGFTILSKKTLHLGQTLYVVNGDLTEVRCDAVVHPTNGTMSFAGQVGGAIRAAAGAGVDAEVNSYMSEHSQLQVTKAAITSGHNLPSKWIVHVHSPNYSNAATATDALTQTIRNALTLADTKSIKTIAFPSIGSGNNHFPKHIAAQTILQAISAYFMSIMSSSIKEVYFVLFDQESINVYNAELINTN

http://purl.uniprot.org/uniprot/A0A0D2UG83#attribution-8F13921F8DE6DB5BF391EC90B28AD09B
creator: UniProtKB
manual: true
evidence: ECO_0000314
source: http://purl.uniprot.org/citations/34887560

http://purl.uniprot.org/uniprot/A0A0D2UG83#attribution-3C22704B2992384D81D9F268BCFFE936
manual: true
evidence: ECO_0000250
source: O75367

http://purl.uniprot.org/uniprot/A0A0D2UG83#attribution-C3DCB0D3760E25B7259C516DBC9C014F
manual: true
evidence: ECO_0000250
source: O93327

http://purl.uniprot.org/uniprot/A0A0D2UG83#attribution-9BA560563AC9F014535E0686BB2102DD
manual: true
evidence: ECO_0000255
source: PRU00490

http://purl.uniprot.org/uniprot/A0A0D2UG83#attribution-9F55B11A581A5C0F961B881192E2471B
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/34887560

http://purl.uniprot.org/uniprot/A0A0D2UG83#attribution-22575115052A528A153BC883132946F0
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/34887560

http://purl.uniprot.org/uniprot/A0A0D2UG83#attribution-547ED88FA9277913CBCA02D1BAF68DBD
manual: true
evidence: ECO_0000305

http://purl.uniprot.org/uniprot/A0A0D2UG83#attribution-EE9334A3FF5BE43ACC6F639E27B313C7
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/34887560

http://purl.uniprot.org/uniprot/A0A0D2UG83#attribution-6B5E4552304F476494C154AE284681D0
manual: true
evidence: ECO_0000312
source: KJE94086.1

http://purl.uniprot.org/uniprot/A0A0D2UG83#attribution-24ECB3FBD92524D58C3A814CFD088EE9
manual: true
evidence: ECO_0007744
source: 7NY6

http://purl.uniprot.org/uniprot/A0A0D2UG83#attribution-7A6C49160720AF1BFE7F368320CD3453
manual: true
evidence: ECO_0007744
source: 7NY7