Extensive metabolic versatility and redundancy in microbially diverse, dynamic hydrothermal sediments.
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
TRANSCRIPTION TERMINATION/ANTITERMINATION PROTEIN NUSA
Prokaryotic type KH domain (KH-domain type II)
Probable transcription termination protein NusA
Participates in transcription termination.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
Heterohexamer of two alpha and four beta subunits.
Belongs to the prefoldin subunit beta family.
DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10
Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
Phosphoribosylformylglycinamidine synthase subunit PurS
phosphoribosylformylglycinamidine synthase, purS protein
Formylglycinamide ribonucleotide amidotransferase subunit III
Phosphoribosylformylglycinamidine synthase subunit III
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7
Belongs to the snRNP Sm proteins family.
P-loop containing nucleotide triphosphate hydrolases
P-loop containing nucleoside triphosphate hydrolases
Cob(I)yrinic acid a,c-diamide adenosyltransferase
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Consists of a catalytic RNA component and at least 4-5 protein subunits.
Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED
Glucocorticoid receptor-like (DNA-binding domain)
Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.
Belongs to the eukaryotic ribosomal protein eL24 family.
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Belongs to the eukaryotic ribosomal protein eS8 family.
Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.
Belongs to the universal ribosomal protein uL14 family.
Ribosomal-protein-alanine N-acetyltransferase
5' to 3' exonuclease, C-terminal subdomain
DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein
DNA-directed RNA polymerase RBP11-like dimerisation
Belongs to the eukaryotic ribosomal protein eL39 family.
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
Belongs to the universal ribosomal protein uL22 family.
Alpha-D-phosphohexomutase, C-terminal domain
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
Belongs to the universal ribosomal protein uS19 family.
NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L
NADH-quinone oxidoreductase subunit NuoK
Metalloproteases ('zincins'), catalytic domain
Probable zinc metalloprotease whose natural substrate is unknown.
Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.
Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
Belongs to the histone-like Alba family.
C-terminal domain of transcriptional repressors
Belongs to the eukaryotic ribosomal protein eS28 family.
DNA-DIRECTED RNA POLYMERASES I, II, AND III
DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC4
DNA-directed RNA polymerase subunit Rpo12
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Belongs to the eukaryotic ribosomal protein eL37 family.
DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1
beta and beta-prime subunits of DNA dependent RNA-polymerase
DNA-directed RNA polymerase subunit Rpo1C
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
Belongs to the RNA polymerase beta' chain family.
CBS DOMAIN-CONTAINING PROTEIN CBSX3, MITOCHONDRIAL
L-ASPARTATE SEMIALDEHYDE SULFURTRANSFERASE IRON-SULFUR SUBUNIT
4Fe-4S ferredoxin-type domain-containing protein
Lrp/AsnC family transcriptional regulator
Transcription regulator AsnC/Lrp ligand binding
AbrB/MazE/SpoVT family DNA-binding domain-containing protein
Nucleoside Triphosphate Pyrophosphohydrolase
Located at the polypeptide exit tunnel on the outside of the subunit.
One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
Belongs to the universal ribosomal protein uL24 family.
lambda repressor-like DNA-binding domains
TRANSCRIPTION REGULATOR, LRP/ASNC FAMILY
Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
Homodimer. Heterotetramer of two Top6A and two Top6B chains.
Spo11/DNA topoisomerase VI subunit A N-terminal
IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED
Fe-S cluster assembly (FSCA) domain-like
NIF system FeS cluster assembly NifU C-terminal
Type II toxin-antitoxin system HicA family toxin
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
Belongs to the universal ribosomal protein uS17 family.
HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE
Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
Asp-tRNA(Asn) amidotransferase GatCAB subunit C
Belongs to the eukaryotic ribosomal protein eS27 family.
DIPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN DPPB-RELATED
Belongs to the binding-protein-dependent transport system permease family.
H/ACA ribonucleoprotein complex, subunit Nop10
H/ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3
Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.
Proteasome assembly chaperone family protein
May be involved in maturation of the 30S ribosomal subunit.
Belongs to the eukaryotic ribosomal protein eS19 family.
30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.
Belongs to the universal ribosomal protein uS13 family.
uncharacterized conserved protein from methanopyrus kandleri domain like
Belongs to the eukaryotic ribosomal protein eS17 family.
Sulphur transport domain-containing protein
Protein transport protein Sec61 subunit beta homolog
Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
Belongs to the universal ribosomal protein uS15 family.
FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD
Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
Lacks conserved residue(s) required for the propagation of feature annotation.
Belongs to the archaeal histone HMF family.
Transcription factor CBF/NF-Y/archaeal histone
ABC TRANSPORTER ATP-BINDING PROTEIN ALBC-RELATED
ABC transporter domain-containing protein
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.
Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
Belongs to the archaeal DnaG primase family.
ArnR1-like winged helix-turn-helix domain-containing protein
3-isopropylmalate dehydratase large subunit
Cytochrome-c3 hydrogenase, C-terminal domain
NADH:ubiquinone oxidoreductase-like, 20kDa subunit
NIFE / NIFESE HYDROGENASE SMALL SUBUNIT FAMILY MEMBER
Heterodimer of a large and a small subunit.
Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
NADH:ubiquinone oxidoreductase-like 20kDa subunit
4Fe4S-binding SPASM domain-containing protein
Histidine kinase-like ATPase, C-terminal domain
PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Homodimeric domain of signal transducing histidine kinase
GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB
Belongs to the helicase family. RAD25/XPB subfamily.
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Belongs to the class-I aminoacyl-tRNA synthetase family.
Methionyl-tRNA synthetase anticodon-binding
TYPE II SECRETION SYSTEM PROTEIN GSPE-RELATED
Bacterial type II secretion system protein E
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.
Belongs to the universal ribosomal protein uL3 family.
Serine-tRNA synthetase, tRNA binding domain
SERINE--TRNA LIGASE, CYTOPLASMIC-RELATED
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
Homodimer. The tRNA molecule binds across the dimer.
Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
Aminoacyl-transfer RNA synthetases class-II family profile
Protein kinase domain-containing protein
Fibronectin type-III domain-containing protein
MEMBRANE COMPONENT OF TRANSPORTER-RELATED
STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3
Isocitrate/Isopropylmalate dehydrogenase-like
THREONINE--TRNA LIGASE, CHLOROPLASTIC/MITOCHONDRIAL 2
Aminoacyl-tRNA synthetase class II (G/ P/ S/T)
Rhodanese/Cell cycle control phosphatase
COB--COM HETERODISULFIDE REDUCTASE IRON-SULFUR SUBUNIT A
FERREDOXIN:COB-COM HETERODISULFIDE REDUCTASE SUBUNIT A
Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.
Aminoglycoside phosphotransferase domain-containing protein
Iron-sulfur cluster assembly scaffold protein
2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain
Belongs to the alpha-IPM synthase/homocitrate synthase family.
Prepilin type IV endopeptidase peptidase domain-containing protein
Prepilin type IV endopeptidase peptidase
Roadblock/LAMTOR2 domain-containing protein
HicB-like antitoxin of toxin-antitoxin system domain-containing protein
Type II secretion system protein GspF domain-containing protein
3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE
Adenine nucleotide alpha hydrolases-like
RsbT co-antagonist protein RsbRD N-terminal domain-containing protein
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
Belongs to the RNase PH family. Rrp41 subfamily.
NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING
RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE B-RELATED
S-adenosyl-L-methionine-dependent methyltransferases
RsmB/NOP family class I SAM-dependent RNA methyltransferase
Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Zn-dependent metallo-hydrolase RNA specificity
Class III signal peptide-containing protein
ZINC METALLOPROTEASE EGY1, CHLOROPLASTIC-RELATED
TUNGSTEN-CONTAINING ALDEHYDE FERREDOXIN OXIDOREDUCTASE COFACTOR MODIFYING PROTEIN
Radical SAM/SPASM domain-containing protein
ARCHAEAL FLAGELLA-RELATED PROTEIN F-RELATED
HTH-TYPE TRANSCRIPTIONAL REGULATOR TRMBL2
Transcription regulator TrmB C-terminal domain-containing protein
3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE
Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))
Phosphoadenosine phosphosulfate reductase
5-FORMAMINOIMIDAZOLE-4-CARBOXAMIDE-1-(BETA)-D-RIBOFURANOSYL 5'-MONOPHOSPHATE SYNTHETASE-RELATED
Glutathione synthetase ATP-binding domain-like
5-formaminoimidazole-4-carboxamide-1-(Beta)-D-ribofuranosyl 5'-monophosphate synthetase
Belongs to the archaeosine synthase type 1 family.
DNA polymerase family B, C-terminal domain
Ribonuclease H-like superfamily/Ribonuclease H
Belongs to the DNA polymerase type-B family.
DNA-directed DNA polymerase family B multifunctional
PAS domain-containing sensor histidine kinase
Type II secretion system, protein E, N-terminal domain
Membrane protein 6-pyruvoyl-tetrahydropterin synthase-related domain-containing protein
DNA ligase, ATP-dependent, N-terminal domain
ATP-dependent DNA ligase DNA-binding domain
DNA ligase/mRNA capping enzyme, catalytic domain
Alpha-galactosidase NEW3 domain-containing protein
Alpha-2-macroglobulin bait region domain-containing protein
5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate--formate ligase
Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.
Belongs to the phosphohexose mutase family.
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.
Heterodimer of a large subunit and a small subunit.
Belongs to the archaeal DNA polymerase II family.
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.
Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
Belongs to the type II topoisomerase GyrB family.
Belongs to the type II topoisomerase family.
Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
S-layer protein C-terminal domain-containing protein
SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL
Mechanosensitive channel protein MscS (YggB), C-terminal domain
Mechanosensitive channel protein MscS (YggB), transmembrane region
Mechanosensitive ion channel family protein
MEMBRANE-ASSOCIATED ZINC METALLOPROTEASE M50B
PHOSPHATE REGULATORY PROTEIN-LIKE PROTEIN
PHOSPHATE-SPECIFIC TRANSPORT SYSTEM ACCESSORY PROTEIN PHOU
Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING
GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)
N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Response regulatory domain-containing protein
Cell wall-binding repeat 2 family protein
MalT-like TPR region domain-containing protein
Sulfur carrier protein ThiS sulfurtransferase
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
Eight-cysteine-cluster domain-containing protein
IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7
Belongs to the imidazoleglycerol-phosphate dehydratase family.
ANAEROBIC SULFATASE-MATURATING ENZYME HOMOLOG ASLB-RELATED
PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE SUBUNIT PURQ
Formylglycinamide ribonucleotide amidotransferase subunit I
Phosphoribosylformylglycinamidine synthase subunit I
NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL
NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT
Belongs to the complex I 49 kDa subunit family.
TRNA (CYTOSINE(48)-C(5))-METHYLTRANSFERASE
SAM-dependent tRNA/rRNA cytosine-C5 methylase
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
orc1/cdc6 family replication initiation protein
Involved in regulation of DNA replication.
DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 1
DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2
EXPORTED CALCIUM-BINDING GLYCOPROTEIN-RELATED
Glycosyl hydrolase family 32 N-terminal domain-containing protein
Glycerophosphoryl diester phosphodiesterase membrane domain-containing protein
Divalent-metal-dependent TIM barrel enzymes
HYPOTHETICAL MEMBRANE PROTEIN, CONSERVED, DUF63 FAMILY
Transferase(Phosphotransferase) domain 1
NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE
Belongs to the protein kinase superfamily. BUD32 family.
Probable tRNA pseudouridine synthase domain
ANTILISTERIAL BACTERIOCIN SUBTILOSIN BIOSYNTHESIS PROTEIN ALBA
Radical SAM core domain-containing protein
3-carboxy-cis,cis-mucoante lactonizing enzyme
Flagellar FlhF biosynthesis protein, N domain
SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA
Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.
Carbamoyl-phosphate synthase small subunit, N-terminal domain
CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN
Carbamoyl phosphate synthetase, small subunit N-terminal domain
Carbamoyl-phosphate synthase small chain
Carbamoyl-phosphate synthetase glutamine chain
Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
Carbamoyl-phosphate synthase small subunit N-terminal
Photosynthesis system II assembly factor Ycf48/Hcf136-like domain-containing protein
Flagellar hook-associated protein 2 C-terminal domain-containing protein
Terpenoid cyclases/Protein prenyltransferases
Squalene cyclase C-terminal domain-containing protein
BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD
HISTIDINE--TRNA LIGASE, MITOCHONDRIAL-RELATED
Belongs to the class-II aminoacyl-tRNA synthetase family.
ATP-DEPENDENT ZINC METALLOPROTEASE FTSH 4, MITOCHONDRIAL
RecF/RecN/SMC N-terminal domain-containing protein
ABC transporter type 1, transmembrane domain
ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL
CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL
CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL-RELATED
Glycoside-hydrolase family GH114 TIM-barrel domain-containing protein
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
Belongs to the ATP-dependent AMP-binding enzyme family.
Type II secretion system protein GspE N-terminal
PGF-CTERM sorting domain-containing protein
TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X
Peptidase M10 metallopeptidase domain-containing protein
CDP-alcohol phosphatidyltransferase family protein
CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5
H/ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1
Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
tRNA intron endonuclease, N-terminal domain
tRNA-intron endonuclease catalytic domain-like
tRNA-intron endonuclease N-terminal domain-like
Belongs to the universal ribosomal protein uS3 family.
BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE/SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC
SDH C-terminal domain-containing protein
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Fructose-1,6-Bisphosphatase, subunit A, domain 1
Binds 1 Mg(2+) or Mn(2+) ion per subunit.
PERIPLASMIC BINDING COMPONENT OF ABC TRANSPORTER
Peptide ABC transporter substrate-binding protein
Belongs to the bacterial solute-binding protein 5 family.
Oligopeptide ABC transporter ATP-binding protein
FlgD/Vpr Ig-like domain-containing protein
In the C-terminal section; belongs to the transposase 35 family.
Probable transposase IS891/IS1136/IS1341
Ribonuclease Y N-terminal domain-containing protein
Bacterial type II secretion system protein E domain-containing protein
MucB/RseB N-terminal domain-containing protein
Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
CDC48 N-terminal subdomain domain-containing protein
Magnesium chelatase subunit I, C-Terminal domain
ATPase dynein-related AAA domain-containing protein
NADPH-DEPENDENT 7-CYANO-7-DEAZAGUANINE REDUCTASE
Tetrahydrobiopterin biosynthesis enzymes-like
With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.
Belongs to the universal ribosomal protein uS12 family.
DNA replication complex GINS family protein
CANCER-RELATED NUCLEOSIDE-TRIPHOSPHATASE
Nucleoside triphosphate phosphohydrolase
Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.
Phosphoglycerate kinase, N-terminal domain
PHOSPHOGLYCERATE KINASE 1, CHLOROPLASTIC-RELATED
Belongs to the phosphoglycerate kinase family.
UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
Aspartate-beta-semialdehyde dehydrogenase
Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
Belongs to the aspartate-semialdehyde dehydrogenase family.
Homing endonuclease LAGLIDADG domain-containing protein
Peptidase A24A-predicted C-terminal archaea
NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58
Sigma3 and sigma4 domains of RNA polymerase sigma factors
D-ribose-5-phosphate isomerase (RpiA), lid domain
Thioredoxin-like fold domain-containing protein
Glycosyltransferase RgtA/B/C/D-like domain-containing protein
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
Winged helix-turn-helix domain-containing protein
Belongs to the universal ribosomal protein uS2 family.
Transglutaminase-like domain-containing protein
TRK SYSTEM POTASSIUM UPTAKE PROTEIN TRKG-RELATED
Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
60S ribosome subunit biogenesis protein NIP7 pre-PUA
IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISH
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
VapC toxin family PIN domain ribonuclease
Transcription regulator TrmB N-terminal domain-containing protein
Glycosyltransferase 2-like domain-containing protein
Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE
ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER
RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER
5-phospho-D-ribosyl alpha-1-diphosphate synthase
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
Ribose-phosphate pyrophosphokinase N-terminal
Eukaryotic type KH-domain (KH-domain type I)
Glycoside hydrolase family 38, central domain
Families 57/38 glycoside transferase middle domain
Glycoside hydrolase family 38 central domain-containing protein
Type IV secretion system coupling protein TraD DNA-binding domain-containing protein
Type IV secretion system coupling protein TraD DNA-binding
DIAMINOPIMELATE DECARBOXYLASE 1, CHLOROPLASTIC-RELATED
Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.
Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
VITAMIN B12-DEPENDENT RIBONUCLEOTIDE REDUCTASE
R1 subunit of ribonucleotide reductase, N-terminal domain
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Belongs to the ribonucleoside diphosphate reductase class-2 family.
Belongs to the ribonucleoside diphosphate reductase large chain family.
PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME
PYRUVATE FORMATE-LYASE-ACTIVATING ENZYME
Anaerobic ribonucleoside-triphosphate reductase activating protein
Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.
Belongs to the DNA polymerase delta/II small subunit family.
DNA polymerase alpha/delta/epsilon subunit B
Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Belongs to the group II decarboxylase family.
Rad50/SbcC-type AAA domain-containing protein
Polymerase nucleotidyl transferase domain-containing protein
AbiEi antitoxin C-terminal domain-containing protein
F420-non-reducing hydrogenase iron-sulfur subunit D domain-containing protein
F420-non-reducing hydrogenase iron-sulfur subunit D
GMP synthase [glutamine-hydrolyzing] subunit A
Catalyzes the synthesis of GMP from XMP.
Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).
Resolvase/invertase-type recombinase catalytic
DIAMINOPIMELATE EPIMERASE, CHLOROPLASTIC
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
Belongs to the diaminopimelate epimerase family.
Could be important to modulate the pK values of the two catalytic cysteine residues
Nucleotidyltransferase domain-containing protein
DOD-type homing endonuclease domain-containing protein
Proteasome endopeptidase complex, archaeal, beta subunit
Guanylate cyclase domain-containing protein
CYTOCHROME C-TYPE BIOGENESIS PROTEIN CCMF
Cytochrome c assembly protein domain-containing protein
Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
CdvA-like coiled-coil domain-containing protein
Thymidylate synthase-complementing protein Thy1
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
Belongs to the thymidylate synthase ThyX family.
Involved in ionization of N3 of dUMP, leading to its activation
ligand shared between neighboring subunits
Zinc finger/thioredoxin putative domain-containing protein
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
Homohexamer. Organized in a ring with a central cavity.
Belongs to the peptidase S16 family. Archaeal LonB subfamily.
ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.
Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
Single-stranded right-handed beta-helix, Pectin lyase-like
Peptidase S8/S53 domain-containing protein
HYDROGENASE EXPRESSION/FORMATION PROTEIN HUPK
Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
FLAGELLAR BIOSYNTHESIS PROTEIN FLHA-RELATED
FLAGELLAR EXPORT PROTEIN, MEMBRANE FLHA SUBUNIT-RELATED
EscV/YscV/HrcV family type III secretion system export apparatus protein
Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
Transposase IS200-like domain-containing protein
tRNA uridine(34) 5-carboxymethylaminomethyl modification radical SAM/GNAT enzyme Elp3
Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
DNA polymerase II large subunit DP2 N-terminal
Archaeal Type IV pilin N-terminal domain-containing protein
Nucleoside diphosphate kinase-like domain
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
OLIGOPEPTIDE TRANSPORT ATP-BINDING PROTEIN APPD
PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE
PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE
L-isoaspartyl protein carboxyl methyltransferase
Protein-beta-aspartate methyltransferase
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
tRNA-guanine(15) transglycosylase-like domain-containing protein
MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1
MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A
Molybdenum cofactor biosynthesis protein A
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
Belongs to the radical SAM superfamily. MoaA family.
CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR
CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER
ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL
Thiamin diphosphate-binding fold (THDP-binding)
Binds 1 thiamine pyrophosphate per subunit.
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Type I restriction modification DNA specificity domain-containing protein
YVTN repeat-like/Quinoprotein amine dehydrogenase
C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
Secretion system C-terminal sorting domain-containing protein
Membrane transport protein MMPL domain-containing protein
Aspartate/ornithine carbamoyltransferase
ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL
ORNITHINE TRANSCARBAMYLASE, MITOCHONDRIAL
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
ABC-TYPE MULTIDRUG TRANSPORT SYSTEM, PERMEASE COMPONENT
PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO
PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED
Pyridoxal 5'-phosphate synthase subunit PdxT
Pyridoxal 5'-phosphate synthase glutaminase subunit
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.
Belongs to the glutaminase PdxT/SNO family.
TRANSCRIPTION INITIATION FACTOR IIB-RELATED
Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
C4-DICARBOXYLATE TRANSPORT SENSOR PROTEIN DCTB
DNA ligase ATP-dependent C-terminal domain-containing protein
PROBABLE GENERAL SECRETION PATHWAY PROTEIN D
TYPE IV PILIATION SYSTEM PROTEIN DR_0774-RELATED
Secretin/TonB short N-terminal domain-containing protein
PST FAMILY PREDICTED COLANIC ACID TRANSPORTER
Polysaccharide biosynthesis protein C-terminal domain-containing protein
OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED
Transposase IS4-like domain-containing protein
ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1
Bacterial fluorinating enzyme, N-terminal domain
Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.
Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER
EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
Translation initiation factor IF-2 subunit gamma
HTH cro/C1-type domain-containing protein
Purple acid phosphatase-like, N-terminal
Purple acid phosphatase, N-terminal domain
Thioesterase/thiol ester dehydrase-isomerase
Belongs to the thioesterase PaaI family.
TRNA (CYTIDINE(56)-2'-O)-METHYLTRANSFERASE
tRNA ribose 2'-O-methyltransferase aTrm56
Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
DNA methylase N-4/N-6 domain-containing protein
Cytochrome c7-like domain-containing protein
SEPTUM SITE-DETERMINING PROTEIN MIND HOMOLOG, CHLOROPLASTIC-RELATED
Type II toxin-antitoxin system MqsA family antitoxin
Type II toxin-antitoxin system VapC family toxin
Type II toxin-antitoxin system RelE/ParE family toxin
UDP-Glycosyltransferase/glycogen phosphorylase
Glycosyl transferase family 1 domain-containing protein
OLIGOPEPTIDE/DIPEPTIDE ABC TRANSPORTER, ATPASE SUBUNIT
CRISPR-ASSOCIATED ENDORIBONUCLEASE CAS2 3
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
Homodimer, forms a heterotetramer with a Cas1 homodimer.
Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3
Ribosomal RNA large subunit methyltransferase E
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT
Macrolide ABC transporter ATP-binding protein
GLYCO_HYDRO_42 DOMAIN-CONTAINING PROTEIN
TIGR03986 family CRISPR-associated RAMP protein
ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED
FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER
7-cyano-7-deazaguanine tRNA-ribosyltransferase
Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.
Belongs to the archaeosine tRNA-ribosyltransferase family.
MEIOTIC RECOMBINATION PROTEIN DMC1/LIM15 HOMOLOG
RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER
DNA repair and recombination protein RadA
Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
Belongs to the eukaryotic RecA-like protein family.
Vitamin K epoxide reductase domain-containing protein
RRNA N6-ADENOSINE-METHYLTRANSFERASE METTL5
Winged helix-turn-helix transcriptional regulator
Carboxypeptidase-like, regulatory domain
Carboxypeptidase regulatory-like domain-containing protein
DNA methylase adenine-specific domain-containing protein
Glycosyltransferase subfamily 4-like N-terminal
Methyl-accepting chemotaxis protein (MCP) signaling domain
SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATC
SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATC, CHLOROPLASTIC-RELATED
LPXTG cell wall anchor domain-containing protein
IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF
IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H
Imidazole glycerol phosphate synthase subunit HisF
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
Ligand-binding domain in the NO signalling and Golgi transport
Metanogen output domain-containing protein
Methanolan biosynthesis EpsI domain-containing protein
Histidine kinase domain-containing protein
TRANSCOBALAMIN-1/GASTRIC INTRINSIC FACTOR
PYRIDOXAL PHOSPHATE PHOSPHATASE YBHA-RELATED
Binds the lower part of the 30S subunit head.
Glycosyl hydrolase-like 10 domain-containing protein
Intracellular proteinase inhibitor BsuPI domain-containing protein
Methyl-accepting transducer domain-containing protein
Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
N-ACETYLMURAMOYL-L-ALANINE AMIDASE-RELATED
Cell wall-binding repeat-containing protein
Anaphase-promoting complex subunit 4 WD40 domain-containing protein
Histidine kinase/HSP90-like ATPase domain-containing protein
Formate dehydrogenase/DMSO reductase domain
RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE C
Belongs to the chorismate synthase family.
Belongs to the archaeal adenylate kinase family.
Site-specific DNA-methyltransferase (adenine-specific)
Bacteriophage SPP1 head-tail adaptor protein
Alpha-L-rhamnosidase six-hairpin glycosidase domain-containing protein
ATP DEPENDENT LON PROTEASE FAMILY MEMBER
Restriction endonuclease type IV Mrr domain-containing protein
Medium-chain alcohol dehydrogenases, catalytic domain
VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11
6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase
Adenylosuccinate Synthetase, subunit A, domain 1
Adenylosuccinate Synthetase, subunit A, domain 2
Adenylosuccinate Synthetase, subunit A, domain 3
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.
TRANSCRIPTION REGULATOR, ENCODED NEXT TO RECA SUPERFAMILY ATPASE-RELATED
KaiC associated regulatory domain-containing protein
Multidrug resistance efflux transporter EmrE
SLC41 divalent cation transporters, integral membrane domain
Belongs to the SLC41A transporter family.
PROTEIN-GLUTAMATE METHYLESTERASE/PROTEIN-GLUTAMINE GLUTAMINASE
Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Belongs to the aspartate/ornithine carbamoyltransferase superfamily.
Phenylalanyl-trna Synthetase, Chain B, domain 3
PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE/PHOSPHATASE
Sulfolobus fructose-1,6-bisphosphatase-like
Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
Belongs to the FBP aldolase/phosphatase family.
Proton acceptor; for FBP phosphatase activity
Proton donor/acceptor; for FBP aldolase activity
Schiff-base intermediate with DHAP; for FBP aldolase activity
VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 29
Belongs to the metallophosphoesterase superfamily. YfcE family.
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.
Belongs to the 2H phosphoesterase superfamily. ThpR family.
N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain
N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE
TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE
tRNA 2,2-dimethylguanosine-26 methyltransferase
tRNA(guanine-26,N(2)-N(2)) methyltransferase
Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
Multidrug efflux transporter AcrB transmembrane domain
SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL
Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Plays an important role in substrate specificity
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Dinitrogenase iron-molybdenum cofactor biosynthesis domain
DINITROGENASE IRON-MOLYBDENUM COFACTOR PROTEIN-RELATED
Dinitrogenase iron-molybdenum cofactor biosynthesis protein
Dinitrogenase iron-molybdenum cofactor biosynthesis
NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL
Belongs to the complex I 20 kDa subunit family.
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
50S RIBOSOMAL PROTEIN L29, CHLOROPLASTIC
60S RIBOSOMAL PROTEIN L35/50S RIBOSOMAL PROTEIN L29
Belongs to the universal ribosomal protein uL29 family.
VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR
Belongs to the V-ATPase 116 kDa subunit family.
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
Alanyl-transfer RNA synthetases family profile
Acetolactate synthase small subunit C-terminal
Glutamine amidotransferase type-2 domain-containing protein
ATP PHOSPHORIBOSYLTRANSFERASE ATP-PRTASE
L-GLUTAMINE--4-(METHYLSULFANYL)-2-OXOBUTANOATE AMINOTRANSFERASE
inorganic pyrophosphatase (n-terminal core)
BIFUNCTIONAL OLIGORIBONUCLEASE AND PAP PHOSPHATASE NRNA
Forms part of the polypeptide exit tunnel.
One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
Belongs to the universal ribosomal protein uL4 family.
4FE-4S CLUSTER CONTAINING PARA FAMILY ATPASE PROTEIN
Part of the protein translocation apparatus. Forms a complex with SecF.
Belongs to the SecD/SecF family. SecD subfamily.
Spermidine synthase, tetramerisation domain
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
Belongs to the spermidine/spermine synthase family.
Polymerase beta nucleotidyltransferase domain-containing protein
MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE
PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE
ATPASE INVOLVED IN CHROMOSOME PARTITIONING, PARA/MIND FAMILY
B3/B4 tRNA-binding domain-containing protein
HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE C
7-HYDROXYMETHYL CHLOROPHYLL A REDUCTASE, CHLOROPLASTIC
ATP-BINDING CASSETTE SUB-FAMILY E MEMBER 1
Ribosome biogenesis/translation initiation ATPase RLI
Diphthamide synthesis DPH1/DPH2 domain 1
Belongs to the carbohydrate kinase PfkB family.
Aldehyde Ferredoxin Oxidoreductase Protein, subunit A, domain 2
Aldehyde Ferredoxin Oxidoreductase Protein, subunit A, domain 3
TUNGSTEN-CONTAINING ALDEHYDE FERREDOXIN OXIDOREDUCTASE
Aldehyde ferredoxin oxidoreductase, C-terminal domains
Aldehyde ferredoxin oxidoreductase C-terminal
DNA topoisomerase VI subunit B transducer
AP_ENDONUC_2 DOMAIN-CONTAINING PROTEIN-RELATED
ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV
Produces ATP from ADP in the presence of a proton gradient across the membrane.
Belongs to the V-ATPase D subunit family.
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
Belongs to the universal ribosomal protein uL5 family.
Nitrogenase molybdenum iron protein domain
HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
Belongs to the histidinol dehydrogenase family.
Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
4-DEOXY-4-FORMAMIDO-L-ARABINOSE-PHOSPHOUNDECAPRENOL DEFORMYLASE ARND-RELATED
Polysaccharide biosynthesis protein C-terminal
Phosphoribosylaminoimidazole-succinocarboxamide synthase
Belongs to the SAICAR synthetase family.
Composite domain of metallo-dependent hydrolases
Amidohydrolase-related domain-containing protein
CobQ/CobB/MinD/ParA nucleotide binding domain-containing protein
RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain
Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.
HOMOLOGY TO DEATH-ON-CURING PROTEIN OF PHAGE P1
INDOLEPYRUVATE OXIDOREDUCTASE SUBUNIT IORA
Indolepyruvate ferredoxin oxidoreductase subunit alpha
Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
Heterodimer of the IorA and IorB subunits.
PHOTOSYSTEM II STABILITY/ASSEMBLY FACTOR HCF136, CHLOROPLASTIC
Oligoxyloglucan reducing end-specific cellobiohydrolase
Photosynthesis system II assembly factor Ycf48/Hcf136-like
dihydropteroate synthase-related protein
NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL
Formate dehydrogenase/DMSO reductase, domains 1-3
Formylmethanofuran dehydrogenase subunit B
LamG-like jellyroll fold domain-containing protein
Bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs), Chain M, domain 3
Bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs), Chain M, domain 5
Carbon monoxide dehydrogenase alpha subunit. Chain D, domain 4
ACETYL-COA DECARBONYLASE/SYNTHASE COMPLEX SUBUNIT BETA 2
Acetyl-CoA decarbonylase/synthase complex subunit beta
Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).
Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
CO dehydrogenase/acetyl-CoA synthase complex beta subunit C-terminal
FEMO COFACTOR BIOSYNTHESIS PROTEIN NIFB-RELATED
REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT
Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.
Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
Belongs to the activator 1 small subunits family. RfcS subfamily.
FIMBRIAL ASSEMBLY PROTEIN PILO-LIKE PROTEIN-RELATED
TYPE IV PILUS INNER MEMBRANE COMPONENT PILO
Nucleotidyltransferase substrate binding subunit/domain
Belongs to the eukaryotic ribosomal protein eS31 family.
LOR/SDH bifunctional enzyme, conserved domain
DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08740)-RELATED
Xylose isomerase-like TIM barrel domain-containing protein
DTDP-4-AMINO-4,6-DIDEOXYGALACTOSE TRANSAMINASE
ABC TRANSPORTER PERMEASE PROTEIN MJ0413-RELATED
ALKANE SULFONATE ABC TRANSPORTER-RELATED, MEMBRANE SUBUNIT
PPM-type phosphatase domain-containing protein
Binds 16S rRNA, required for the assembly of 30S particles.
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
D-amino Acid Aminotransferase, subunit A, domain 2
D-aminoacid aminotransferase-like PLP-dependent enzymes
Aminodeoxychorismate synthase, component I
PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE-RELATED
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)
Nickel pincer cofactor biosynthesis protein LarB
Dinitrogenase iron-molybdenum cofactor biosynthesis domain-containing protein
S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME
S-adenosylmethionine decarboxylase beta chain
S-adenosylmethionine decarboxylase alpha chain
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
Binds 1 pyruvoyl group covalently per subunit.
Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.
Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
Schiff-base intermediate with substrate; via pyruvic acid
Proton acceptor; for processing activity
[FEFE] HYDROGENASE MATURASE SUBUNIT HYDE
N-acetyltransferase domain-containing protein
POTASSIUM CHANNEL PROTEIN 2-RELATED-RELATED
RCK N-TERMINAL DOMAIN-CONTAINING PROTEIN
AMINO ACID ABC TRANSPORTER PERMEASE PROTEIN
BRANCHED-CHAIN AMINO ACID TRANSPORT SYSTEM PERMEASE PROTEIN LIVH
Branched-chain amino acid ABC transporter permease
Carbamoyl-phosphate synthetase, large subunit oligomerisation domain
Carbamoyl phosphate synthetase, large subunit connection domain
Carbamoyl-phosphate synthase large chain
Carbamoyl-phosphate synthetase ammonia chain
Binds 4 Mg(2+) or Mn(2+) ions per subunit.
ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED
B12-binding domain-containing radical SAM protein
Sporulation stage II protein D amidase enhancer LytB N-terminal domain-containing protein
Sporulation stage II protein D amidase enhancer LytB N-terminal
SHORT CHAIN ISOPRENYL DIPHOSPHATE SYNTHASE
Belongs to the FPP/GGPP synthase family.
EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN
Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.
Belongs to the RNase PH family. Rrp42 subfamily.
N(4)-bis(aminopropyl)spermidine synthase C-terminal
Cell growth inhibitor/plasmid maintenance toxic component
Type II toxin-antitoxin system PemK/MazF family toxin
S-methyl-5-thioribose-1-phosphate isomerase
Belongs to the eIF-2B alpha/beta/delta subunits family.
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding domain-containing protein
Signal recognition particle, SRP19-like subunit
SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN
SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.
GLYCINE CLEAVAGE SYSTEM H PROTEIN, MITOCHONDRIAL
Belongs to the archaeal riboflavin kinase family.
COB--COM HETERODISULFIDE REDUCTASE SUBUNIT B 1
EUKARYOTIC TRANSLATION INITIATION FACTOR
EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2
Translation initiation factor 2 beta, aIF2beta, N-terminal domain
Zinc-binding domain of translation initiation factor 2 beta
Translation initiation factor 2 subunit beta
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
Heterotrimer composed of an alpha, a beta and a gamma chain.
3-OCTAPRENYL-4-HYDROXYBENZOATE CARBOXY-LYASE-RELATED
L-asparaginase N-terminal domain-containing protein
Nucleotidyl transferase AbiEii/AbiGii toxin family protein
ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
Aspartate aminotransferase family protein
MAGNESIUM PROTOPORPHYRIN IX METHYLTRANSFERASE, CHLOROPLASTIC
Methyltransferase type 11 domain-containing protein
Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
ABC-type transport auxiliary lipoprotein component
paralog of FGE (formylglycine-generating enzyme)
Sulfatase-modifying factor enzyme domain-containing protein
Adenine nucleotide alpha hydrolase family protein
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
METALLO-BETA-LACTAMASE DOMAIN-CONTAINING
Belongs to the prefoldin alpha subunit family.
Belongs to the prefoldin subunit alpha family.
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
Creatinase/methionine aminopeptidase superfamily
C-terminal effector domain of the bipartite response regulators
Pyruvate carboxyltransferase domain-containing protein
Type II toxin-antitoxin system HicB family antitoxin
HicB-like antitoxin of toxin-antitoxin system
BIOTIN SYNTHASE-RELATED PROTEIN, RADICAL SAM SUPERFAMILY
DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2
Belongs to the RNA polymerase beta chain family.
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.
Belongs to the universal ribosomal protein uL2 family.
Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.
Type I-A CRISPR-associated protein Cas4/Csa1
FORMATE DEHYDROGENASE, NITRATE-INDUCIBLE, MAJOR SUBUNIT
TUNGSTEN-CONTAINING FORMYLMETHANOFURAN DEHYDROGENASE 2 SUBUNIT B
4Fe-4S Mo/W bis-MGD-type domain-containing protein
Right handed beta helix domain-containing protein
TRNA(PHE) (4-DEMETHYLWYOSINE(37)-C(7)) AMINOCARBOXYPROPYLTRANSFERASE
Class I SAM-dependent methyltransferase family protein
SAM-dependent methyltransferase TRM5/TYW2-type
Alpha-glycerophosphate oxidase, cap domain
D-Amino Acid Oxidase, subunit A, domain 2
ANAEROBIC GLYCEROL-3-PHOSPHATE DEHYDROGENASE SUBUNIT A
Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
Alpha-glycerophosphate oxidase C-terminal
Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.
Belongs to the archaeal flagellin family.
LINEARMYCIN RESISTANCE ATP-BINDING PROTEIN LNRL
N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE REDUCTASE, CHLOROPLASTIC-RELATED
N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE REDUCTASE, CHLOROPLASTIC-RELATED-RELATED
N-acetyl-gamma-glutamyl-phosphate reductase
N-acetyl-glutamate semialdehyde dehydrogenase
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
POLYNUCLEOTIDYL TRANSFERASE, RIBONUCLEASE H-LIKE SUPERFAMILY PROTEIN
Lon proteolytic domain-containing protein
Belongs to the SIS family. PHI subfamily.
TYPE I RESTRICTION ENZYME ECOKI R PROTEIN
Helicase/UvrB N-terminal domain-containing protein
Polymerase/histidinol phosphatase N-terminal
DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED
DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
Belongs to the helicase family. Hel308 subfamily.
4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL
SirC, precorrin-2 dehydrogenase, C-terminal helical domain-like
CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2
NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED
Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
Belongs to the Mrp/NBP35 ATP-binding proteins family.
Iron dependent repressor, metal binding and dimerisation domain
IRON (METAL) DEPENDENT REPRESSOR, DTXR FAMILY
Iron-dependent repressor protein, dimerization domain
Metal-dependent transcriptional regulator
NADH:ubiquinone oxidoreductase-like 20kDa subunit domain-containing protein
PROTEIN ADENYLYLTRANSFERASE MJ0128-RELATED
FERREDOXIN:COB-COM HETERODISULFIDE REDUCTASE SUBUNIT C
IRON-SULFUR-BINDING OXIDOREDUCTASE FADF-RELATED-RELATED
PHOSPHOMETHYLPYRIMIDINE SYNTHASE, CHLOROPLASTIC
Hydroxymethylpyrimidine phosphate synthase
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
TYPE III RESTRICTION-MODIFICATION SYSTEM HINDVIP ENZYME MOD-RELATED
Belongs to the N(4)/N(6)-methyltransferase family.
Flagellar motor switch protein FliN-like C-terminal
Carbamoyl phosphate synthase small subunit
Cysteine-tRNA ligase, C-terminal anti-codon recognition domain
Probable brix-domain ribosomal biogenesis protein
FAD dependent oxidoreductase domain-containing protein
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.
Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Carbohydrate-binding/sugar hydrolysis domain-containing protein
BRANCHED-CHAIN AMINO ACID TRANSPORT PERMEASE PROTEIN LIVH-RELATED
TYPE-1 RESTRICTION ENZYME ECOKI SPECIFICITY PROTEIN
TYPE-1 RESTRICTION ENZYME MJAXIP SPECIFICITY PROTEIN
Belongs to the type-I restriction system S methylase family.
Type I restriction modification DNA specificity
Transposase IS605 OrfB C-terminal domain-containing protein
ABC TRANSPORTER ATP-BINDING PROTEIN NATA
Heme ABC exporter ATP-binding protein CcmA
DIGERANYLGERANYLGLYCEROPHOSPHOLIPID REDUCTASE
Belongs to the eukaryotic ribosomal protein eS4 family.
Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
DNA-directed RNA polymerase, insert domain
DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
Insert subdomain of RNA polymerase alpha subunit
DNA-directed RNA polymerase subunit Rpo3
Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Belongs to the eukaryotic ribosomal protein eL30 family.
Molybdopterin dinucleotide-binding domain-containing protein
UPF0173 METAL-DEPENDENT HYDROLASE MJ1163-RELATED
FAD-binding/transporter-associated domain-like
Glycosyl hydrolase family 13 catalytic domain-containing protein
S-adenosyl-l-methionine hydroxide adenosyltransferase, N-terminal
Bacterial fluorinating enzyme, C-terminal domain
Belongs to the SAM hydrolase / SAM-dependent halogenase family.
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
Homodecamer. Pentamer of dimers that assemble into a ring structure.
The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
Belongs to the peroxiredoxin family. Prx6 subfamily.
Cysteine sulfenic acid (-SOH) intermediate
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Interchain (with Cys-211); in linked form
Interchain (with Cys-50); in linked form
translation initiation factor eif-2b, domain 1
Putative methylthioribose-1-phosphate isomerase
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Signal recognition particle SRP54, nucleotide-binding domain
Signal recognition particle, SRP54 subunit, M-domain
SIGNAL RECOGNITION PARTICLE 54 KDA PROTEIN
SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54
Domain of the SRP/SRP receptor G-proteins
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
The SRP-RNC complex is targeted to the cytoplasmic membrane.
Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Signal recognition particle SRP54 helical bundle
ALIPHATIC SULFONATES IMPORT ATP-BINDING PROTEIN SSUB
TAURINE IMPORT ATP-BINDING PROTEIN-RELATED
Belongs to the eukaryotic ribosomal protein eL19 family.
SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11
N-terminal domain of the delta subunit of the F1F0-ATP synthase
ATP SYNTHASE SUBUNIT DELTA, CHLOROPLASTIC
MOLYBDENUM TRANSPORT SYSTEM PERMEASE PROTEIN MODB
Belongs to the eukaryotic ribosomal protein eS1 family.
5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE-RELATED
METHENYLTETRAHYDROFOLATE SYNTHASE DOMAIN-CONTAINING PROTEIN
HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN
HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HISIE
UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE
6-phosphogluconate dehydrogenase C-terminal domain-like
UDP-glucose/GDP-mannose dehydrogenase C-terminal domain
Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
UDP-glucose/GDP-mannose dehydrogenase C-terminal
S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC
Uroporphyrinogen-III C-methyltransferase
Belongs to the precorrin methyltransferase family.
EUKARYOTIC TRANSLATION INITIATION FACTOR 5A
TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER
Functions by promoting the formation of the first peptide bond.
Translation elongation factor IF5A C-terminal
COLANIC ACID BIOSYNTHESIS GLYCOSYL TRANSFERASE WCAI-RELATED
Belongs to the eukaryotic ribosomal protein eL42 family.
Gamma-glutamylcyclotransferase AIG2-like domain-containing protein
Gamma-glutamylcyclotransferase AIG2-like
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE
Belongs to the thiolase-like superfamily. UPF0219 family.
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Peptidase C1A papain C-terminal domain-containing protein
Belongs to the CitM (TC 2.A.11) transporter family.
BIFUNCTIONAL GLUTAMATE/PROLINE--TRNA LIGASE
EUKARYOTIC PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Heterodimer of two subunits, one of which binds GTP.
Belongs to the eukaryotic release factor 1 family.
TRNA-SPECIFIC ADENOSINE DEAMINASE-RELATED
Probable S-methyl-5'-thioinosine phosphorylase
Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
RIBOSOMAL_L23EN DOMAIN-CONTAINING PROTEIN
Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
Part of the 50S ribosomal subunit. Contacts protein L29.
Belongs to the universal ribosomal protein uL23 family.
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
Dihydromethanopterin reductase (Acceptor)
ATP-DEPENDENT HELICASE LHR-RELATED-RELATED
Nitrite and sulphite reductase 4Fe-4S domain-like
Nitrite/Sulfite reductase N-terminal domain-like
Sulfite reductase, dissimilatory-type subunit alpha
GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED
GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL
Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase GatCAB subunit B
Aspartyl/Glutamyl-tRNA(Gln) amidotransferase subunit B/E catalytic
DNA-DIRECTED RNA POLYMERASE, SUBUNIT F (RPOF)
DNA-directed RNA polymerase subunit Rpo4
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.
Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
MOLYBDENUM COFACTOR GUANYLYLTRANSFERASE-RELATED
Probable molybdenum cofactor guanylyltransferase
Molybdopterin-guanine dinucleotide synthase
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
Part of the protein translocation apparatus. Forms a complex with SecD.
Belongs to the SecD/SecF family. SecF subfamily.
ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SAMP2)
Belongs to the eukaryotic ribosomal protein eL31 family.
Belongs to the ribosomal protein L31e family.
Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3
Alpha-D-phosphohexomutase alpha/beta/alpha
Hybrid sensor histidine kinase/response regulator
Belongs to the V-ATPase F subunit family.
1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III
INDOLEPYRUVATE OXIDOREDUCTASE SUBUNIT IORB
Pyruvate/ketoisovalerate oxidoreductase catalytic domain-containing protein
Pyruvate/ketoisovalerate oxidoreductase catalytic
PHOSPHATE TRANSPORT SYSTEM PERMEASE PROTEIN PST
PHOSPHATE TRANSPORT SYSTEM PERMEASE PROTEIN PSTC
Phosphate ABC transporter permease subunit PstC
ANAEROBIC NITRIC OXIDE REDUCTASE FLAVORUBREDOXIN
Flavodoxin-like domain-containing protein
ABC TRANSPORTER I FAMILY MEMBER 6, CHLOROPLASTIC
SULFOPYRUVATE DECARBOXYLASE SUBUNIT ALPHA
OSMOSENSING HISTIDINE PROTEIN KINASE SLN1
NADH:ubiquinone oxidoreductase, 30kDa subunit
NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL
NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3
NADH:ubiquinone oxidoreductase 30kDa subunit
ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINE O-ACYLTRANSFERASE
Tryptophan synthase beta subunit-like PLP-dependent enzymes
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
Tetramer of two alpha and two beta chains.
Tryptophan synthase beta chain-like PALP
MFS general substrate transporter like domains
MAJOR FACILITATOR SUPERFAMILY TRANSPORTER
Major facilitator superfamily (MFS) profile domain-containing protein
Major facilitator superfamily (MFS) profile
ASPARAGINE SYNTHETASE (GLUTAMINE-HYDROLYZING)
Putative asparagine synthetase [glutamine-hydrolyzing]
Important for beta-aspartyl-AMP intermediate formation
Peptidase S54 rhomboid domain-containing protein
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
Mg(2+) or Mn(2+) required for ssDNA cleavage activity.
Belongs to the CRISPR-associated exonuclease Cas4 family.
Tubulin/FtsZ GTPase domain-containing protein
ATP-SYNT_AB DOMAIN-CONTAINING PROTEIN-RELATED
C-terminal domain of alpha and beta subunits of F1 ATP synthase
Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.
Belongs to the ATPase alpha/beta chains family.
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Glutamine--scyllo-inositol aminotransferase
General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
Aldehyde ferredoxin oxidoreductase, N-terminal domain
Aldehyde ferredoxin oxidoreductase N-terminal
L(+)-TARTRATE DEHYDRATASE SUBUNIT ALPHA-RELATED
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
RNA 3'-terminal phosphate cyclase domain
RNA 3'-terminal phosphate cyclase, insert domain
RNA 3'-terminal phosphate cyclase, RPTC, insert domain
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
RNA 3'-terminal phosphate cyclase insert
Electron transport complex subunit B, putative Fe-S cluster
ACETYL-COA DECARBONYLASE/SYNTHASE COMPLEX SUBUNIT GAMMA
Molybdopterin synthase sulfur carrier subunit
NAD(P)H-DEPENDENT FMN-CONTAINING OXIDOREDUCTASE YWQN-RELATED
COFACTOR-INDEPENDENT PHOSPHOGLYCERATE MUTASE
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
Transcriptional regulatory protein pf0864 domain like
PYRIDINIUM-3,5-BISTHIOCARBOXYLIC ACID MONONUCLEOTIDE NICKEL INSERTION PROTEIN
Nickel pincer cofactor biosynthesis protein LarC
TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT ALPHA
TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT
Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.
Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
The winged helix domain is involved in binding to DNA in the preinitiation complex.
Leucine-binding protein domain-containing protein
Belongs to the universal ribosomal protein uL18 family.
40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11
Located on the platform of the 30S subunit.
Belongs to the universal ribosomal protein uS11 family.
Type I-B CRISPR-associated protein Cas7/Cst2/DevR
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
CBS DOMAIN-CONTAINING PROTEIN CBSX2, CHLOROPLASTIC
L-ASPARTATE SEMIALDEHYDE SULFURTRANSFERASE
Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
Binds 2 Mg(2+) or Mn(2+) ions per subunit.
CBS DOMAIN-CONTAINING PROTEIN CBSX1, CHLOROPLASTIC
MIND SUPERFAMILY P-LOOP ATPASE CONTAINING AN INSERTED FERREDOXIN DOMAIN
NADH-quinone oxidoreductase subunit NuoH
3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT 1-RELATED
3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT 2-RELATED-RELATED
Aconitase A/isopropylmalate dehydratase small subunit swivel
Glutamyl-tRNA(Gln) amidotransferase subunit D
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
Belongs to the asparaginase 1 family. GatD subfamily.
Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
Belongs to the pseudouridine synthase TruD family.
Type III-B CRISPR module RAMP protein Cmr1
HIGH-AFFINITY BRANCHED-CHAIN AMINO ACID TRANSPORT SYSTEM PERMEASE
GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT E
Glu-tRNA(Gln) amidotransferase GatDE subunit E
Methenyltetrahydromethanopterin cyclohydrolase
Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-H(4)MPT.
Poly(A) polymerase predicted RNA binding domain
PAP/Archaeal CCA-adding enzyme, C-terminal domain
FORMATE LYASE ACTIVATING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15630)-RELATED
Belongs to the small heat shock protein (HSP20) family.
Toxic component of a toxin-antitoxin (TA) system. An RNase.
Belongs to the PINc/VapC protein family.
Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.
Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
GLYCYL-RADICAL ENZYME ACTIVATING ENZYME MJ0021-RELATED
tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family
Protein transport protein SEC61 subunit alpha homolog
The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
Putative modulator of DNA gyrase, PmbA/TldD
Aspartate dehydrogenase domain-containing protein
Formate/glycerate dehydrogenase catalytic domain-like
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
Belongs to the adenosylhomocysteinase family.
S-adenosyl-L-homocysteine hydrolase NAD binding
Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.
Belongs to the GHMP kinase family. PoK subfamily.
Belongs to the universal ribosomal protein uS9 family.
Transmembrane di-heme cytochromes, Chain C
FORMATE DEHYDROGENASE, NITRATE-INDUCIBLE, CYTOCHROME B556 FDN SUBUNIT
Cytochrome b561 bacterial/Ni-hydrogenase domain-containing protein
Cytochrome b561 bacterial/Ni-hydrogenase
DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2
DNA-directed RNA polymerase subunit Rpo6
Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A
N-terminal domain of alpha and beta subunits of F1 ATP synthase
Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.
Periplasmic copper-binding protein NosD beta helix domain-containing protein
Periplasmic copper-binding protein NosD beta helix
RESISTANCE PROTEIN MDTM, PUTATIVE-RELATED-RELATED
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.
Assembles at midcell at the inner surface of the cytoplasmic membrane.
Signal recognition particle receptor FtsY
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.
Belongs to the GTP-binding SRP family. FtsY subfamily.
CO dehydrogenase/acetyl-CoA synthase delta subunit TIM barrel
KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL
HYDROGENASE PROTEIN ASSEMBLY PROTEIN HYPD
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
DNA helicase RuvA subunit, C-terminal domain
Nascent polypeptide-associated complex domain
Nascent polypeptide-associated complex protein
Contacts the emerging nascent chain on the ribosome.
Homodimer. Interacts with the ribosome. Binds ribosomal RNA.
K(+)-INSENSITIVE PYROPHOSPHATE-ENERGIZED PROTON PUMP
Membrane-bound proton-translocating pyrophosphatase
Pyrophosphate-energized inorganic pyrophosphatase
Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.
Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
ACETOLACTATE SYNTHASE SMALL SUBUNIT 2, CHLOROPLASTIC
Acetohydroxy-acid synthase small subunit
Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
Belongs to the acetolactate synthase small subunit family.
Elongation Factor G (Translational Gtpase), domain 3
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
Conserved hypothetical protein from pyrococcus furiosus pfu- 392566-001, ParB domain
Belongs to the V-ATPase proteolipid subunit family.
Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase
Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
Belongs to the methyltransferase superfamily. Fibrillarin family.
FLAGELLA-RELATED PROTEIN E-RELATED-RELATED
Archaeal flagella protein FlaD/E domain-containing protein
TRNA(ILE2) 2-AGMATINYLCYTIDINE SYNTHETASE TIAS
ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
F420-dependent methylenetetrahydromethanopterin dehydrogenase (MTD)
F420-dependent methylenetetrahydromethanopterin dehydrogenase
Coenzyme F420-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase
Catalyzes the oxidation of methylene-H(4)MPT to methenyl-H(4)MPT(+).
Phosphoribosylglycinamide synthetase C-domain domain-containing protein
Phosphoribosylglycinamide synthetase C-domain
JHP933, nucleotidyltransferase-like core domain
Com family DNA-binding transcriptional regulator
CONSERVED COMPONENT OF ABC TRANSPORTER FOR NATURAL AMINO ACIDS-RELATED
F1F0 ATP synthase subunit B, membrane domain
ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED
Belongs to the V-ATPase E subunit family.
RNA polymerase Rpb7-like, N-terminal domain
DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7
N-terminal, heterodimerisation domain of RBP7 (RpoE)
DNA-directed RNA polymerase subunit Rpo7
Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.
Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
PEP-CTERM protein-sorting domain-containing protein
[FeFe] hydrogenase H-cluster radical SAM maturase HydE
PROTEASOME SUBUNIT ALPHA TYPE-7-1-RELATED
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.
The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
MOLYBDATE/TUNGSTATE-BINDING PROTEIN WTPA
Tungstate ABC transporter substrate-binding protein WtpA
Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.
Formylmethanofuran:tetrahydromethanopterin formyltransferase
Formylmethanofuran--tetrahydromethanopterin N-formyltransferase
Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr N-terminal
Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr C-terminal
Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.
Proliferating cell nuclear antigen PCNA N-terminal
Proliferating cell nuclear antigen PCNA C-terminal
PD-(D/E)XK endonuclease-like domain-containing protein
UNDECAPRENYL-PHOSPHATE ALPHA-N-ACETYLGLUCOSAMINYL 1-PHOSPHATE TRANSFERASE
Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
ligand shared between two adjacent protomers
Lysine tRNA ligase, stem contact fold domain
An anticodon-binding domain of class I aminoacyl-tRNA synthetases
Aminoacyl-tRNA synthetase class I anticodon-binding
DNA REPAIR AND RECOMBINATION PROTEIN RADB
Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.
Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED
3-HYDROXY-5-PHOSPHONOOXYPENTANE-2,4-DIONE THIOLASE-RELATED
DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
DNA-directed RNA polymerase subunit Rpo5
Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
RNA polymerase subunit H/Rpb5 C-terminal
Part of the 50S ribosomal subunit. Binds 23S rRNA.
Belongs to the eukaryotic ribosomal protein eL20 family.
Ribosomal protein 50S-L18Ae/60S-L20/60S-L18A
SPERMIDINE/PUTRESCINE IMPORT ATP-BINDING PROTEIN POTA
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
Belongs to the eukaryotic ribosomal protein eS6 family.
ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ
ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ, MITOCHONDRIAL
SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE RECJ
Heterooligomer of catalytic and regulatory chains.
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN DIMETHYLTRANSFERASE
Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
S-ADENOSYLMETHIONINE:TRNA RIBOSYLTRANSFERASE-ISOMERASE
tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA
SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATA
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
ATPASE_AAA_CORE DOMAIN-CONTAINING PROTEIN
6-oxocyclohex-1-ene-1-carbonyl-CoA hydratase
HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HIS7
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
Quinolinate phosphoribosyl transferase, N-terminal domain
Nicotinate/Quinolinate PRTase C-terminal domain-like
Nicotinate/Quinolinate PRTase N-terminal domain-like
Quinolinate phosphoribosyl transferase C-terminal
Type III-B CRISPR module RAMP protein Cmr4
ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3
Activating enzymes of the ubiquitin-like proteins
Belongs to the LysR transcriptional regulatory family.
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.
Belongs to the universal ribosomal protein uL10 family.
Binds directly to 23S rRNA. Probably involved in E site tRNA release.
Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.
Belongs to the universal ribosomal protein uL1 family.
Belongs to the ParA family. MinD subfamily.
Belongs to the eukaryotic ribosomal protein eS24 family.
TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER
Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN
Belongs to the cytidylate kinase family. Type 2 subfamily.
Dihydroorotate dehydrogenase, electron transfer subunit
Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module
DIHYDROOROTATE DEHYDROGENASE B (NAD(+)), ELECTRON TRANSFER SUBUNIT
DIHYDROOROTATE DEHYDROGENASE B (NAD(+)), ELECTRON TRANSFER SUBUNIT-RELATED
Ferredoxin reductase-like, C-terminal NADP-linked domain
Dihydroorotate dehydrogenase electron transfer subunit
Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
Translation initiation factor IF- 2, domain 3
EUKARYOTIC TRANSLATION INITIATION FACTOR 5B
TRANSLATION INITIATION FACTOR IF-2-RELATED
Probable translation initiation factor IF-2
Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
6-phosphogluconate dehydrogenase C-terminal like domain
Ferrodoxin-fold anticodon-binding domain
ATP-dependent DNA helicase RecG C-terminal
OB FOLD NUCLEIC ACID BINDING PROTEIN-RELATED
Aspartate/homoserine dehydrogenase NAD-binding
1,4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE
UBIA PRENYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1
Carbon monoxide dehydrogenase alpha subunit. Chain M, domain 1
ACETYL-COA DECARBONYLASE/SYNTHASE COMPLEX SUBUNIT ALPHA
Belongs to the V-ATPase V0D/AC39 subunit family.
RecA family profile 1 domain-containing protein
CHEMORECEPTOR GLUTAMINE DEAMIDASE CHED-RELATED
CNF1/YfiH-like putative cysteine hydrolases
Probable chemoreceptor glutamine deamidase CheD
Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.
Glutamine phosphoribosylpyrophosphate amidotransferase
Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
Belongs to the universal ribosomal protein uS4 family.
PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED
pyridoxal 5'-phosphate synthase, synthase subunit Pdx1
Pyridoxal 5'-phosphate synthase subunit PdxS
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
In the presence of PdxT, forms a dodecamer of heterodimers.
Schiff-base intermediate with D-ribose 5-phosphate
HYDROGENASE PROTEIN ASSEMBLY PROTEIN, NICKEL CHAPERONE
3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE
Substrate-binding domain of HMG-CoA reductase
3-hydroxy-3-methylglutaryl coenzyme A reductase
Belongs to the HMG-CoA reductase family.
Peptidase C14 caspase domain-containing protein
Belongs to the transcriptional regulator TrmB family.
AB hydrolase-1 domain-containing protein
UNDECAPRENYL-PHOSPHATE 4-DEOXY-4-FORMAMIDO-L-ARABINOSE TRANSFERASE-RELATED
MEMBRANE TRANSPORTER PROTEIN MJ0441-RELATED
MEMBRANE TRANSPORTER PROTEIN YTNM-RELATED
Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
MEMBRANE TRANSPORTER PROTEIN HI_0806-RELATED
Belongs to the eukaryotic ribosomal protein eL34 family.
Aspartate/glutamate/uridylate kinase domain-containing protein
Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.
Belongs to the HAD-like hydrolase superfamily.
Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
Helicase HerA central domain-containing protein
BRANCHED-CHAIN AMINO ACID TRANSPORT ATP-BINDING PROTEIN LIVF-RELATED
HIGH-AFFINITY BRANCHED-CHAIN AMINO ACID TRANSPORT ATP-BINDING PROTEIN LIVF
Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.
Belongs to the PEP-utilizing enzyme family.
Pyruvate phosphate dikinase AMP/ATP-binding
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Hydantoinase A/oxoprolinase domain-containing protein
O-PHOSPHO-L-SERYL-TRNA:CYS-TRNA SYNTHASE
Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
Belongs to the GatB/GatE family. GatB subfamily.
Asl1-like glycosyl hydrolase catalytic domain-containing protein
N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL
N-acetyl-L-glutamate 5-phosphotransferase
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
Belongs to the acetylglutamate kinase family. ArgB subfamily.
HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2
TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE
TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE, MITOCHONDRIAL
Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
Purple acid phosphatase N-terminal domain-containing protein
carbamoyl-phosphate synthase (glutamine-hydrolyzing)
HYDROGENASE ISOENZYMES FORMATION PROTEIN HYPE
Hydrogenase expression/formation protein HypE
Pseudouridine synthase I, catalytic domain, C-terminal subdomain
Pseudouridine synthase I, catalytic domain, N-terminal subdomain
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
Belongs to the tRNA pseudouridine synthase TruA family.
Pseudouridine synthase I TruA alpha/beta
PYRUVATE-FLAVODOXIN OXIDOREDUCTASE-RELATED
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
EUKARYOTIC TRANSLATION INITIATION FACTOR 6
Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.
3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE
Leucine Aminopeptidase, subunit E, domain 1
Belongs to the HAD-like hydrolase superfamily. SerB family.
Reverse gyrase zinc finger domain-containing protein
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE
ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL
Isocitrate/isopropylmalate dehydrogenase family protein
CheC-like protein domain-containing protein
THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED
Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.
Belongs to the threonine synthase family.
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
Belongs to the universal ribosomal protein uS7 family.
Branched-chain-amino-acid aminotransferase
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
VALINE--TRNA LIGASE, CHLOROPLASTIC/MITOCHONDRIAL 2
Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
translation elongation factor selb, chain A, domain 4
Belongs to the eukaryotic ribosomal protein eL33 family.
Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.
Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
5-AMINO-6-(5-PHOSPHO-D-RIBITYLAMINO)URACIL PHOSPHATASE YIGB
CoB--CoM heterodisulfide reductase subunit B
Translation elongation factor-like protein
Bacterial extracellular solute-binding protein, family 7
C4-dicarboxylate ABC transporter substrate-binding protein
LATE ENDOSOMAL/LYSOSOMAL MP1 INTERACTING PROTEIN
Calcium-transporting ATPase, transmembrane domain
Cation-transporting P-type ATPase C-terminal
Type III-B CRISPR module-associated protein Cmr3
Sulfopyruvate decarboxylase subunit beta
Belongs to the eukaryotic ribosomal protein eL21 family.
ATP--dephospho-CoA triphosphoribosyl transferase CitG
5,10-methylenetetrahydrofolate reductase
Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
AMINO-ACID METABOLITE EFFLUX PUMP-RELATED
NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL
3',5'-CYCLIC ADENOSINE MONOPHOSPHATE PHOSPHODIESTERASE CPDA
Pyruvoyl-Dependent Histidine Decarboxylase, subunit B
PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE
Pyruvoyl-dependent histidine and arginine decarboxylases
arginine decarboxylase, pyruvoyl-dependent
Pyruvoyl-dependent arginine decarboxylase subunit beta
Pyruvoyl-dependent arginine decarboxylase subunit alpha
MobA-like NTP transferase domain-containing protein
Molybdopterin biosynthesis moea protein, domain 2
Molybdopterin biosynthesis moea protein, domain 3
MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MJ0666-RELATED
Molybdenum cofactor biosynthesis proteins
Molybdopterin molybdenumtransferase MoeA
2-isopropylmalate synthase LeuA allosteric (dimerisation)
GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE
UDP-glucose--hexose-1-phosphate uridylyltransferase
Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
Galactose-1-phosphate uridyl transferase N-terminal
Galactose-1-phosphate uridyl transferase C-terminal
RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE M
POSSIBLE NUCLEASE OF RNASE H FOLD, RUVC/YQGF FAMILY
Indolepyruvate ferredoxin oxidoreductase subunit beta
Trafficking protein particle complex subunit 3
4-vinyl reductase 4VR domain-containing protein
PERIPLASMIC PHOSPHATE BINDING COMPONENT OF PHOSPHATE ABC TRANSPORTER
EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1
Translation initiation factor IF-2 subunit alpha
ARSENICAL RESISTANCE OPERON REPRESSOR ARSR-RELATED
UDP-N-acetylglucosamine 2-epimerase (Non-hydrolyzing)
Class II aldolase/adducin N-terminal domain
TRANSCRIPTIONAL REGULATOR PROTEIN-LIKE PROTEIN
4Fe-4S dicluster domain-containing protein
COMPONENT OF ATP-DEPENDENT DSDNA EXONUCLEASE
Calcineurin-like phosphoesterase domain-containing protein
Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
GLYCEROL-3-PHOSPHATE CYTIDYLYLTRANSFERASE
Pantetheine-phosphate adenylyltransferase
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]
Quinolinate phosphoribosyltransferase [decarboxylating]
Involved in the catabolism of quinolinic acid (QA).
Quinolinate phosphoribosyl transferase N-terminal
C-terminal domain of RNA polymerase alpha subunit
PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE CATALYTIC SUBUNIT
5-(Carboxyamino)imidazole ribonucleotide mutase
Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase
Mannose-6-phosphate isomerase type II C-terminal
Outer membrane lipoprotein BamD-like domain-containing protein
S-adenosylmethionine synthetase, C-terminal domain
S-adenosylmethionine synthetase, N-terminal domain
Belongs to the universal ribosomal protein uL16 family.
NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ
DNA-directed RNA polymerase M/15kDa subunit domain-containing protein
DNA-directed RNA polymerase M/15kDa subunit
N2-METHYLGUANOSINE TRNA METHYLTRANSFERASE
putative methyltransferase, TIGR01177 family
Alpha-keto-beta-hydroxylacyl reductoisomerase
Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
Belongs to the ketol-acid reductoisomerase family.
OCTANOYL-[GCVH]:PROTEIN N-OCTANOYLTRANSFERASE
Belongs to the isopentenyl phosphate kinase family.
FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD
Belongs to the myo-inositol 1-phosphate synthase family.
Myo-inositol-1-phosphate synthase GAPDH-like
MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA
PurM-like C-terminal domain-containing protein
Phosphoribosyltransferase domain-containing protein
Gfo/Idh/MocA-like oxidoreductase N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Exosome-associated factor Rrp6 N-terminal domain-containing protein
Exosome-associated factor Rrp6 N-terminal
Glucose-1-phosphate thymidylyltransferase
mini-chromosome maintenance (MCM) complex, chain A, domain 1
DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER
RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG
Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
Belongs to the TDD superfamily. TSR3 family.
RNase L inhibitor RLI-like possible metal-binding
16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal
putative n-type atp pyrophosphatase, domain 2
DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN
NI/FE-HYDROGENASE 1 B-TYPE CYTOCHROME SUBUNIT
NI/FE-HYDROGENASE 1 B-TYPE CYTOCHROME SUBUNIT-RELATED
Cytochrome b/b6 domain-containing protein
THIF-type NAD/FAD binding fold domain-containing protein
GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE
GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE 1, CHLOROPLASTIC-RELATED
Glutamate-1-semialdehyde aminotransferase
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2
HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY
PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE
Coenzyme A biosynthesis bifunctional protein CoaBC
DNA/pantothenate metabolism flavoprotein
Phosphopantothenoylcysteine synthetase/decarboxylase
Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
In the C-terminal section; belongs to the PPC synthetase family.
In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
DNA/pantothenate metabolism flavoprotein C-terminal
ibrinogen binding protein from staphylococcus aureus domain
Fibronectin-binding domain-containing protein
Belongs to the eukaryotic ribosomal protein eL43 family.
Resolvase/invertase-type recombinase catalytic domain-containing protein
Carbohydrate-binding domain-containing protein
NICKEL IMPORT SYSTEM PERMEASE PROTEIN NIKC
OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN APPC
Tetrapyrrole biosynthesis uroporphyrinogen III synthase domain-containing protein
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Type II secretion system (T2SS), domain F
Ribosomal protein L11, C-terminal domain
Ribosomal protein L11/L12, N-terminal domain
39S RIBOSOMAL PROTEIN L11, MITOCHONDRIAL
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.
Belongs to the universal ribosomal protein uL11 family.
CLASS IV SAM-BINDING METHYLTRANSFERASE-RELATED
4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE SYNTHASE THI11-RELATED
THIAMINE BIOSYNTHESIS PROTEIN HI_0357-RELATED
Solute-binding protein family 3/N-terminal
Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.
Belongs to the EF-1-beta/EF-1-delta family.
Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange
Metallo-beta-lactamase domain-containing protein
Putative peptide-modifying radical SAM/SPASM domain-containing protein
Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.
Argininosuccinate synthetase, chain A, domain 2
Argininosuccinate synthetase, C-terminal domain
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase
S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE
S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED
tRNA wyosine derivatives biosynthesis protein Taw1
Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
Bifunctional IPC transferase and DIPP synthase
In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family.
In the N-terminal section; belongs to the MobA family.
Catalyzes the attachment of tryptophan to tRNA(Trp).
DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS
DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER
Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
Belongs to the mannose-6-phosphate isomerase type 2 family.
Fumarylacetoacetase-like, C-terminal domain
FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A
FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A-RELATED
2-hydroxyhepta-2,4-diene-1,7-dioate isomerase
Nmd3 N-terminal domain-containing protein
Rhomboid family intramembrane serine protease
Probable glycine cleavage system H protein
The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
The glycine cleavage system is composed of four proteins: P, T, L and H.
CO dehydrogenase flavoprotein, C-terminal domain
PHOSPHORIBOSYLAMINE--GLYCINE LIGASE, CHLOROPLASTIC
Carbohydrate kinase PfkB domain-containing protein
Involved in the binding of tRNA to the ribosomes.
Belongs to the universal ribosomal protein uS10 family.
CHEMOTAXIS SENSOR HISTIDINE KINASE-RELATED
BRANCHED-CHAIN AMINO ACID TRANSPORT PERMEASE PROTEIN LIVM-RELATED
Dehydroquinate synthase-like - alpha domain
Glycerol-1-phosphate dehydrogenase [NAD(P)+]
Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
Belongs to the glycerol-1-phosphate dehydrogenase family.
Nascent polypeptide-associated complex subunit alpha-like UBA
PYRUVATE FORMATE-LYASE ACTIVATING ENZYME HOMOLOG
BIFUNCTIONAL NMN ADENYLYLTRANSFERASE/NUDIX HYDROLASE
Nicotinamide-nucleotide adenylyltransferase
Belongs to the archaeal NMN adenylyltransferase family.
conserved hypothetical integral membrane protein
Probable queuosine precursor transporter
Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.
Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase
Corrinoid/iron-sulfur component large subunit
Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).
Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
GMP synthetase C-terminal dimerisation domain
GMP synthase [glutamine-hydrolyzing] subunit B
Histidine-containing phosphotransfer domain, HPT domain
INTEGRAL MEMBRANE TRANSPORT PROTEIN-RELATED
GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL
Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA
DIGERANYLGERANYLGLYCERYL PHOSPHATE SYNTHASE
(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase
Geranylgeranylglycerol-phosphate geranylgeranyltransferase
Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
AMIDOHYDRO-REL DOMAIN-CONTAINING PROTEIN
5-methylthioadenosine/S-adenosylhomocysteine deaminase
Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
Structural maintenance of chromosome 1. Chain E
Rad21/Rec8-like protein C-terminal eukaryotic domain-containing protein
Rad21/Rec8-like protein C-terminal eukaryotic
3-isopropylmalate dehydratase small subunit
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Belongs to the LeuD family. LeuD type 2 subfamily.
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.
Chemotaxis response regulator protein-glutamate methylesterase
DNA gyrase/topoisomerase IV, subunit A, C-terminal
DNA GYRASE SUBUNIT A, CHLOROPLASTIC/MITOCHONDRIAL
Belongs to the type II topoisomerase GyrA/ParC subunit family.
RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE
Methylated DNA-protein cysteine methyltransferase, C-terminal domain
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
BETA-RIBOFURANOSYLAMINOBENZENE 5'-PHOSPHATE SYNTHASE
Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
Belongs to the beta-RFA-P synthase family.
Uncharacterised protein PF08960, DUF1874
Glutamyl-tRNA reductase, N-terminal domain
Glutamyl tRNA-reductase catalytic, N-terminal domain
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.
During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
Belongs to the glutamyl-tRNA reductase family.
NADH:ubiquinone/plastoquinone oxidoreductase, chain 3
NAD(P)H-quinone oxidoreductase subunit 3
Belongs to the complex I subunit 3 family.
Proliferating cell nuclear antigen (Pcna)
A/G-SPECIFIC ADENINE GLYCOSYLASE/ENDONUCLEASE III
NTP pyrophosphohydrolase MazG putative catalytic core
ABC transporter involved in vitamin B12 uptake, BtuC
Belongs to the ABC-3 integral membrane protein family.
Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.
Belongs to the eukaryotic ribosomal protein P1/P2 family.
Formylmethanofuran dehydrogenase subunit C
CHROMOSOME TRANSMISSION FIDELITY FACTOR 18
DNA replication factor RFC1 C-terminal domain-containing protein
BIFUNCTIONAL NADP PHOSPHATASE/NAD KINASE
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
Belongs to the archaeal phosphopantothenate synthetase family.
METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN
METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G07630)
TYPE II SECRETION SYSTEM PROTEIN F-RELATED
Type II secretion system F family protein
Peptidoglycan binding-like domain-containing protein
Helix-turn-helix type 11 domain-containing protein
Belongs to the thymidylate kinase family.
Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN
non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family
HYPOTHETICAL MEMBRANE PROTEIN, CONSERVED, DUF373 FAMILY
Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
THREONYL AND ALANYL TRNA SYNTHETASE SECOND ADDITIONAL DOMAIN-CONTAINING PROTEIN
phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
HTH-TYPE TRANSCRIPTIONAL REGULATOR MJ1563-RELATED
HTH-TYPE TRANSCRIPTIONAL REGULATOR YVAV-RELATED
Glycosyltransferase subfamily 4-like N-terminal domain-containing protein
GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED
60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N
Belongs to the eukaryotic ribosomal protein eL32 family.
DsrC, the gamma subunit of dissimilatory sulfite reductase
3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE
In the N-terminal section; belongs to the DHBP synthase family.
Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
Heterodimer of a small subunit (PriS) and a large subunit (PriL).
Belongs to the eukaryotic-type primase small subunit family.
BULB-TYPE LECTIN DOMAIN-CONTAINING PROTEIN
ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED
Histidine kinase CheA-like, homodimeric domain
Histidine kinase CheA-like, P2 response regulator-binding domain
conserved putative lor/sdh protein from methanococcus maripaludis s2 domain
Arginyl tRNA synthetase N-terminal domain
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain
IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG
NIF system FeS cluster assembly NifU N-terminal
CTP--2, 3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase
Nitrite/Sulfite reductase ferredoxin-like
TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE
TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE-RELATED
t(6)A37 threonylcarbamoyladenosine biosynthesis protein Kae1
tRNA threonylcarbamoyladenosine biosynthesis protein Kae1
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.
OLIGO/DIPEPTIDE TRANSPORT, PERMEASE PROTEIN (DPPC-2)
2,3-DIKETO-L-GULONATE TRAP TRANSPORTER SMALL PERMEASE PROTEIN YIAM
Non-canonical O-phosphoseryl-tRNA(Cys) synthetase
Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
Translation initiation factor 2 subunit gamma
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE 2
glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating)
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
UPF0173 METAL-DEPENDENT HYDROLASE TM_1162
UPF0173 metal-dependent hydrolase DRN95_04970
Diphthamide biosynthesis methyltransferase
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Belongs to the diphthine synthase family.
C4-DICARBOXYLATE TRAP TRANSPORTER LARGE PERMEASE PROTEIN DCTM
SIALIC ACID TRAP TRANSPORTER PERMEASE PROTEIN SIAT-RELATED
C4-dicarboxylate ABC transporter permease
TRAP C4-dicarboxylate transport system permease DctM subunit
TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3
TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED
phosphoribosylformylglycinamidine cyclo-ligase
AmmeMemoRadiSam system radical SAM enzyme
Sodium/calcium exchanger membrane region
Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)
DNA-(apurinic or apyrimidinic site) lyase
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Type I glyceraldehyde-3-phosphate dehydrogenase
Glyceraldehyde 3-phosphate dehydrogenase catalytic
HypC/HybG/HupF family hydrogenase formation chaperone
CRISPR-associated endonuclease Cas1, C-terminal domain
CRISPR-associated endonuclease Cas1, N-terminal domain
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
Homodimer, forms a heterotetramer with a Cas2 homodimer.
Belongs to the CRISPR-associated endonuclease Cas1 family.
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
Ribosomal RNA adenine methylase transferase N-terminal
PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING
FAD/NAD-linked reductases, dimerisation (C-terminal) domain
Pyridine nucleotide-disulfide oxidoreductase
Pyridine nucleotide-disulphide oxidoreductase dimerisation
CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase
Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
Belongs to the CDP-archaeol synthase family.
5-METHYLCYTOSINE-SPECIFIC RESTRICTION ENZYME B
CONSERVED HYPOTHETICAL CHEMOTAXIS PROTEIN
Protein-glutamate O-methyltransferase CheR
Ribosome maturation protein SBDS, N-terminal domain
SBDS protein C-terminal domain, subdomain 1
RESTRICTION OF TELOMERE CAPPING PROTEIN 3
Hypothetical protein AF0491, middle domain
Ribosome maturation protein SDO1/SBDS N-terminal
Ribosome maturation protein SDO1/SBDS central
Ribosome maturation protein SDO1/SBDS C-terminal
CHROMOSOME-PARTITIONING PROTEIN PARB-RELATED
ParB/Sulfiredoxin domain-containing protein
3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE
SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER
BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE [ASYMMETRICAL]
DIADENOSINE 5,5-P1,P4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE MUTT
Methylene-tetrahydrofolate reductase C-terminal domain-containing protein
Methylene-tetrahydrofolate reductase C-terminal
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.
Belongs to the adenylosuccinate synthetase family.
BRANCHED-CHAIN AMINO ACID TRANSPORT ATP-BINDING PROTEIN LIVG-RELATED
LIPOPROTEIN-RELEASING SYSTEM ATP-BINDING PROTEIN LOLD
DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER
REGULATOR OF TELOMERE ELONGATION HELICASE 1
Belongs to the helicase family. RAD3/XPD subfamily.
Obg-like GTPase YGR210-like G4 motif-containing
DNA-3-methyladenine glycosylase AlkA, N-terminal domain
Iron dependent repressor metal binding and dimerisation
Belongs to the OMP decarboxylase family. Type 2 subfamily.
H4MPT-linked C1 transfer pathway protein
putative toxin-antitoxin system toxin component, PIN family
Protein transport protein Sec61 gamma subunit homolog
Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
DNA POLYMERASE SUBUNIT GAMMA-2, MITOCHONDRIAL
Glutamate synthase, alpha subunit, C-terminal domain
TUNGSTEN FORMYLMETHANOFURAN DEHYDROGENASE, SUBUNIT C (FWDC)
TUNGSTEN-CONTAINING FORMYLMETHANOFURAN DEHYDROGENASE 2 SUBUNIT C
Alpha subunit of glutamate synthase, C-terminal domain
Glutamate synthase alpha subunit C-terminal
POLY-BETA-1,6-N-ACETYL-D-GLUCOSAMINE SYNTHASE
Tyr recombinase domain-containing protein
DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE
DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1
GENERAL SECRETION PATHWAY PROTEIN A-RELATED
Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
Belongs to the archaeal FAD synthase family.
PEP-CTERM sorting domain-containing protein
Pyruvate formate lyase-activating protein
Zinc finger ZPR1-type domain-containing protein
NITROGEN ASSIMILATION TRANSCRIPTIONAL ACTIVATOR-RELATED
OB-fold nucleic acid binding domain-containing protein
Respiratory nitrate reductase 1 gamma chain
Uncharacterised protein PF01937, DUF89, domain 1
Uncharacterised protein PF01937, DUF89, domain 2
Uncharacterised protein PF01937, DUF89, domain 3
Damage-control phosphatase ARMT1-like metal-binding domain-containing protein
Damage-control phosphatase ARMT1-like metal-binding
Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
YeiH family putative sulfate export transporter
Aspartate carbamoyltransferase regulatory subunit, N-terminal domain
ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN
Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain
Aspartate carbamoyltransferase regulatory subunit
Aspartate carbamoyltransferase regulatory subunit N-terminal
TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN
TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN-RELATED
Antitoxin component of a type II toxin-antitoxin (TA) system.
Mga helix-turn-helix domain-containing protein
Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.
Belongs to the L-aspartate dehydrogenase family.
CRISPR-Cas system, Cmr2 subunit, D1 domain, cysteine cluster
CRISPR SYSTEM SINGLE-STRAND-SPECIFIC DEOXYRIBONUCLEASE CAS10/CSM1 (SUBTYPE III-A)
Type III-B CRISPR-associated protein Cas10/Cmr2
PROTEIN ADENYLYLTRANSFERASE MNTA-RELATED
LEU/ILE/VAL-BINDING ABC TRANSPORTER SUBUNIT
Belongs to the leucine-binding protein family.
6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
6-hydroxymethyl-7,8-dihydropterin diphosphokinase
7,8-dihydro-6-hydroxymethylpterin diphosphokinase
7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase
Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).
6-hydroxymethylpterin diphosphokinase MptE-like
Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
Belongs to the type IA topoisomerase family.
O-(5'-phospho-DNA)-tyrosine intermediate
PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit CofH
Type II secretion system protein GspG C-terminal domain-containing protein
Type II secretion system protein GspG C-terminal
Heterotetramer of one alpha, one beta, one delta and one gamma chain.
Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
Regulator of K+ conductance, C-terminal domain
TRK SYSTEM POTASSIUM UPTAKE PROTEIN TRKA
DUF521 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00490)
Aconitase X catalytic domain-containing protein
DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED
PROTEIN COFACTOR ASSEMBLY OF COMPLEX C SUBUNIT B CCB3, CHLOROPLASTIC-RELATED
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
Belongs to the ATP-dependent DNA ligase family.
DNA-binding protein Tfx superfamily, archaea
MacB-like periplasmic core domain-containing protein
2-ISOPROPYLMALATE SYNTHASE 1, CHLOROPLASTIC-RELATED
CO dehydrogenase/acetyl-CoA synthase complex subunit epsilon
4-HYDROXY-TETRAHYDRODIPICOLINATE SYNTHASE
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
Chitobiase/beta-hexosaminidase domain 2-like
Ribulose bisphosphate carboxylase, large subunit, C-terminal domain
RuBisCO large subunit, N-terminal domain
RIBULOSE BISPHOSPHATE CARBOXYLASE LARGE CHAIN
RuBisCO, large subunit, small (N-terminal) domain
Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.
Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
Belongs to the RuBisCO large chain family. Type III subfamily.
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Ribulose bisphosphate carboxylase large subunit C-terminal
CRISPR type III-B/RAMP module-associated protein Cmr5
Belongs to the CRISPR system Cmr5 family.
Nicotinate phosphoribosyltransferase C-terminal
MEMBRANE TRANSPORTER PROTEIN YDHB-RELATED
CRISPR SYSTEM ENDORIBONUCLEASE CSX1-RELATED
TIGR01897 family CRISPR-associated protein
INTEGRAL MEMBRANE EFFLUX PROTEIN-RELATED
LIPOPOLYSACCHARIDE 1,2-N-ACETYLGLUCOSAMINETRANSFERASE-RELATED
archaeoglobus fulgidus dsm 4304 superfamily
UPF0051 PROTEIN ABCI8, CHLOROPLASTIC-RELATED
SufD family Fe-S cluster assembly protein
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.
ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN
PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED
Coenzyme F420 hydrogenase/dehydrogenase beta subunit C-terminal domain-containing protein
Coenzyme F420 hydrogenase/dehydrogenase beta subunit C-terminal
Formylmethanofuran dehydrogenase subunit E
Belongs to the universal ribosomal protein uL15 family.
Asparagine synthetase domain-containing protein
Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
Reaction proceeds via a cis-phosphoenolate intermediate.
Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
BIFUNCTIONAL UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE/N-ACETYLMANNOSAMINE KINASE
DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED
Catalyzes the conversion of dihydroorotate to orotate.
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
Belongs to the universal ribosomal protein uL6 family.
RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE K/L
Class I SAM-dependent RNA methyltransferase
WD_REPEATS_REGION DOMAIN-CONTAINING PROTEIN
ARCHAEAL-TYPE GLUTAMATE SYNTHASE [NADPH]
Belongs to the glutamate synthase family.
CYTOKININ RIBOSIDE 5'-MONOPHOSPHATE PHOSPHORIBOHYDROLASE
PYRIMIDINE/PURINE NUCLEOTIDE 5'-MONOPHOSPHATE NUCLEOSIDASE
Coenzyme F420 hydrogenase/dehydrogenase beta subunit N-terminal domain-containing protein
Coenzyme F420 hydrogenase/dehydrogenase beta subunit N-terminal
OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN
ACETYL-COA DECARBONYLASE/SYNTHASE COMPLEX SUBUNIT DELTA
TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED
TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE
23S rRNA (Uracil(1939)-C(5))-methyltransferase RlmD
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
Glutamyl-tRNA(Gln) amidotransferase subunit A
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Belongs to the amidase family. GatA subfamily.
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
Belongs to the universal ribosomal protein uL13 family.
5-AMINO-6-(D-RIBITYLAMINO)URACIL--L-TYROSINE 4-HYDROXYPHENYL TRANSFERASE
radical SAM domain protein, CofH subfamily
Belongs to the eukaryotic ribosomal protein eL18 family.
Belongs to the carbamoyltransferase HypF family.
UDP-N-acetylglucosamine 2-epimerase domain-containing protein
CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE
METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED
Acetyl-CoA carboxylase biotin carboxylase subunit
Geranylgeranylglyceryl/heptaprenylglyceryl phosphate synthase
Belongs to the eukaryotic ribosomal protein eL40 family.
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER
Formylmethanofuran dehydrogenase subunit A
Belongs to the activator 1 small subunits family. RfcL subfamily.
PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN
Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.
Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
Aminotransferase class I/classII domain-containing protein
Belongs to the desulfoferrodoxin family.
Maltogenic Amylase C-terminal domain-containing protein
FERREDOXIN SUBUNIT OF PYRUVATE:FLAVODOXIN OXIDOREDUCTASE-RELATED
Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
Part of the 50S ribosomal subunit. Probably part of the RNase P complex.
Belongs to the eukaryotic ribosomal protein eL8 family.
Ferrous iron transport protein B C-terminal
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Belongs to the ketopantoate reductase family.
(5-formylfuran-3-yl)methyl phosphate synthase
4-(hydroxymethyl)-2-furancarboxaldehyde-phosphate synthase
Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).
MCM N-terminal domain-containing protein
Twin-arginine translocase TatA/TatE family subunit
1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase
DUF2080 family transposase-associated protein
Transcription initiation factor IIB family protein
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
Belongs to the triosephosphate isomerase family.
Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
Glycosyl transferase family 3 N-terminal
Phosphoribosylformylglycinamidine synthase, linker domain
PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE SUBUNIT PURL
Formylglycinamide ribonucleotide amidotransferase subunit II
Phosphoribosylformylglycinamidine synthase subunit II
Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
Phosphoribosylformylglycinamidine synthase linker
DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5
DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER
DNA-directed RNA polymerase subunit Rpo10
Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
PROTEIN-GLUTAMATE METHYLESTERASE/PROTEIN-GLUTAMINE GLUTAMINASE 1
METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB
Belongs to the methyl-accepting chemotaxis (MCP) protein family.
Type III-B CRISPR module RAMP protein Cmr6
NAD-dependent epimerase/dehydratase domain-containing protein
Cytochrome b/b6 N-terminal region profile domain-containing protein
Cytochrome b/b6 N-terminal region profile
Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
Putative HTH-type transcriptional regulatory protein DRN95_05715
Belongs to the eukaryotic ribosomal protein eL15 family.
Molybdopterin cofactor biosynthesis C (MoaC) domain
Molybdenum cofactor biosynthesis protein C, MoaC
Probable cyclic pyranopterin monophosphate synthase
Molybdenum cofactor biosynthesis protein C
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
Molybdopterin cofactor biosynthesis C (MoaC)
MOLYBDOPTERIN-GUANINE DINUCLEOTIDE BIOSYNTHESIS ADAPTER PROTEIN
MOLYBDOPTERIN-GUANINE DINUCLEOTIDE BIOSYNTHESIS ADAPTER PROTEIN-RELATED
Molybdopterin-guanine dinucleotide biosynthesis protein B
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Formylmethanofuran dehydrogenase subunit E domain-containing protein
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
With S5 and S12 plays an important role in translational accuracy.
Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
MOLYBDOPTERIN SYNTHASE CATALYTIC SUBUNIT
Molybdenum cofactor biosynthesis protein MoaE
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
Belongs to the universal ribosomal protein uS8 family.
DNA-directed RNA polymerase, subunit 2, domain 6
RNA polymerase alpha subunit dimerisation domain
DNA-directed RNA polymerase subunit beta
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
DNA-directed RNA polymerase subunit 2 hybrid-binding
LONG-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
Aspartate carbamoyltransferase regulatory subunit, C-terminal domain
Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain
Involved in allosteric regulation of aspartate carbamoyltransferase.
Contains catalytic and regulatory chains.
Aspartate carbamoyltransferase regulatory subunit C-terminal
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
Threonylcarbamoyladenosine tRNA methylthiotransferase
DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
Bacterial exopeptidase dimerisation domain
Peptidase M20 dimerisation domain-containing protein
3-phosphoshikimate 1-carboxyvinyltransferase
5-enolpyruvylshikimate-3-phosphate synthase
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
GHMP kinase N-terminal domain-containing protein
TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE-RELATED
Archaeal tRNA CCA-adding enzyme catalytic domain
CCA tRNA nucleotidyltransferase, domain 2
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
tRNA nucleotidyltransferase substrate binding
2-HYDROXYGLUTARYL-COA DEHYDRATASE, D-COMPONENT-RELATED
Benzoyl-CoA reductase, bzd-type, subunit O
Belongs to the FldB/FldC dehydratase alpha/beta subunit family.
Methanogenesis regulatory protein FilR1 middle
RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.
Pyrimidine nucleoside phosphorylase-like, C-terminal domain
Pyrimidine nucleoside phosphorylase C-terminal domain
Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
Pyrimidine nucleoside phosphorylase C-terminal
Isopentenyl diphosphate:dimethylallyl diphosphate isomerase
Type 2 isopentenyl diphosphate isomerase
Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
Belongs to the IPP isomerase type 2 family.
N6 adenine-specific DNA methyltransferase N-terminal
ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
3-OXO-TETRONATE 4-PHOSPHATE DECARBOXYLASE-RELATED
ATP-dependent sacrificial sulfur transferase LarE
Hydantoinase B/oxoprolinase domain-containing protein
Branched-chain amino acid ATP-binding cassette transporter C-terminal
CARBON-MONOXIDE DEHYDROGENASE ACCESSORY PROTEIN
Tape measure protein N-terminal domain-containing protein
Transcription regulator PadR N-terminal domain-containing protein
Adenine deaminase C-terminal domain-containing protein
ZINC-RIBBON RNA-BINDING PROTEIN INVOLVED IN TRANSLATION-RELATED
Small zinc finger protein HVO-2753-like zinc-binding pocket
D-MALATE DEHYDROGENASE [DECARBOXYLATING]
2-METHYL-6-PHYTYL-1,4-HYDROQUINONE METHYLTRANSFERASE, CHLOROPLASTIC
LuxC is the fatty acid reductase enzyme responsible for synthesis of the aldehyde substrate for the luminescent reaction catalyzed by luciferase.
Nucleotidyl transferase domain-containing protein
DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER
Has ATPase and non-specific DNA-binding activities.
Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
DNA mismatch repair proteins mutS family
3-hydroxy-3-methylglutaryl-CoA reductase
Catalyzes the decarboxylation of L-aspartate to produce beta-alanine.
Belongs to the group II decarboxylase family. MfnA subfamily.
Porphobilinogen deaminase, C-terminal domain
Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
Binds 1 dipyrromethane group covalently.
The porphobilinogen subunits are added to the dipyrromethane group.
SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED
Dissimilatory-type sulfite reductase subunit beta
MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN B
Molybdenum cofactor biosynthesis protein
Hydrogenase maturation nickel metallochaperone HypA
Adenine-specific Methyltransferase, Domain 2