Evolution of elongation factor 1alpha and elongation factor-like genes in eukaryotes.
P-loop containing nucleotide triphosphate hydrolases
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
P-loop containing nucleoside triphosphate hydrolases
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor
Belongs to the adaptor complexes medium subunit family.
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
Belongs to the myo-inositol 1-phosphate synthase family.
Myo-inositol-1-phosphate synthase GAPDH-like
Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.
Ras-related C3 botulinum toxin substrate 1
Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Prokaryotic type KH domain (KH-domain type II)
Belongs to the universal ribosomal protein uS3 family.
TCP-1-like chaperonin intermediate domain
Belongs to the eukaryotic ribosomal protein eS4 family.
Belongs to the universal ribosomal protein uL29 family.
Belongs to the eukaryotic ribosomal protein eL30 family.
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.
Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
Belongs to the eukaryotic ribosomal protein eL14 family.
SERINE--TRNA LIGASE, CYTOPLASMIC-RELATED
Aminoacyl-transfer RNA synthetases class-II family profile
Belongs to the eukaryotic ribosomal protein eL21 family.
Glucocorticoid receptor-like (DNA-binding domain)
Belongs to the eukaryotic ribosomal protein eL24 family.
Belongs to the eukaryotic ribosomal protein eL20 family.
Ribosomal protein 50S-L18Ae/60S-L20/60S-L18A
S-adenosyl-L-methionine-dependent methyltransferases
DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1
beta and beta-prime subunits of DNA dependent RNA-polymerase
Belongs to the universal ribosomal protein uL13 family.
Component of the 60S subunit of the ribosome.
In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
In the N-terminal section; belongs to the ubiquitin family.
YVTN repeat-like/Quinoprotein amine dehydrogenase
GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA
GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-1
Guanine nucleotide-binding protein beta 3
Belongs to the WD repeat G protein beta family.
Belongs to the universal ribosomal protein uL4 family.
Actin-related protein 2/3 complex subunit 3
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Belongs to the universal ribosomal protein uL3 family.
Belongs to the eukaryotic ribosomal protein eS17 family.
DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER
Belongs to the universal ribosomal protein uS10 family.
26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14
EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED
Belongs to the eukaryotic ribosomal protein eS26 family.
Belongs to the universal ribosomal protein uL24 family.
Belongs to the eukaryotic ribosomal protein eL18 family.
DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1
Belongs to the methyltransferase superfamily. Fibrillarin family.
Belongs to the eukaryotic ribosomal protein eL15 family.
EUKARYOTIC TRANSLATION INITIATION FACTOR 5B
TRANSLATION INITIATION FACTOR IF-2-RELATED
Belongs to the eukaryotic ribosomal protein P1/P2 family.
Creatinase/methionine aminopeptidase superfamily
GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.
Belongs to the small GTPase superfamily. Ran family.
40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11
Belongs to the universal ribosomal protein uS11 family.
Elongation Factor G (Translational Gtpase), domain 3
EUKARYOTIC TRANSLATION ELONGATION FACTOR 2
translation elongation factor selb, chain A, domain 4
Belongs to the eukaryotic ribosomal protein eL33 family.
EUKARYOTIC TRANSLATION INITIATION FACTOR 5A
TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER
mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis.
eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.
Belongs to the universal ribosomal protein uS5 family.
26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT
26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1
Belongs to the universal ribosomal protein uS9 family.
EUKARYOTIC TRANSLATION INITIATION FACTOR 6
Guanine Nucleotide Dissociation Inhibitor, domain 2
FAD-linked reductases, C-terminal domain
Belongs to the universal ribosomal protein uS7 family.
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT
Elongation factor Tu GTP binding domain containing 2
Belongs to the universal ribosomal protein uL6 family.
Belongs to the universal ribosomal protein uL10 family.
RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1
RECEPTOR OF ACTIVATED PROTEIN C KINASE 1
Guanine nucleotide-binding protein subunit beta-2-like 1
Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Belongs to the RNA polymerase beta' chain family.
ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
Belongs to the eukaryotic ribosomal protein eS28 family.
Subunits of heterodimeric actin filament capping protein Capz
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
Heterodimer of an alpha and a beta subunit.
Belongs to the F-actin-capping protein beta subunit family.
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Belongs to the universal ribosomal protein uS2 family.
V-type proton ATPase catalytic subunit D
Belongs to the V-ATPase D subunit family.
Ribosomal protein L11, C-terminal domain
Ribosomal protein L11/L12, N-terminal domain
Belongs to the universal ribosomal protein uL11 family.
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.
Belongs to the universal ribosomal protein uS4 family.
WD REPEAT DOMAIN PHOSPHOINOSITIDE-INTERACTING PROTEIN 3
WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED
WD repeat domain phosphoinositide-interacting protein
SUCCINATE--COA LIGASE [ADP/GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL
Belongs to the universal ribosomal protein uL5 family.
Lacks conserved residue(s) required for the propagation of feature annotation.
ATP-SYNT_AB DOMAIN-CONTAINING PROTEIN-RELATED
V-type proton ATPase catalytic subunit B
Belongs to the ATPase alpha/beta chains family.
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
Belongs to the eukaryotic ribosomal protein eS12 family.
V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A
N-terminal domain of alpha and beta subunits of F1 ATP synthase
ATPsynthase alpha/beta subunit N-terminal extension
Belongs to the eukaryotic ribosomal protein eL8 family.
Belongs to the eukaryotic ribosomal protein eS6 family.
NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58
Thymidylate synthase/dCMP hydroxymethylase domain
Thymidylate synthase/dCMP hydroxymethylase
In the C-terminal section; belongs to the thymidylate synthase family.
In the N-terminal section; belongs to the dihydrofolate reductase family.
Belongs to the universal ribosomal protein uL18 family.
Belongs to the universal ribosomal protein uS8 family.
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N
Belongs to the eukaryotic ribosomal protein eL32 family.
Belongs to the universal ribosomal protein uS19 family.
Belongs to the universal ribosomal protein uS17 family.
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Belongs to the eukaryotic ribosomal protein eL42 family.
Belongs to the eukaryotic ribosomal protein eS8 family.
Belongs to the eukaryotic ribosomal protein eS27 family.
Histidine kinase-like ATPase, C-terminal domain
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Belongs to the heat shock protein 90 family.
30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18
Belongs to the universal ribosomal protein uS13 family.
Belongs to the universal ribosomal protein uL2 family.
Ribosomal protein L30, ferredoxin-like fold domain
Belongs to the universal ribosomal protein uL30 family.
Ribosomal protein L30 ferredoxin-like fold
EUKARYOTIC PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1
60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER
Plays an important role in the elongation step of protein synthesis.
Belongs to the eukaryotic ribosomal protein eL43 family.
Serine-tRNA synthetase, tRNA binding domain
Belongs to the universal ribosomal protein uL22 family.
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Belongs to the eukaryotic ribosomal protein eS10 family.
Belongs to the universal ribosomal protein uL16 family.
Belongs to the eukaryotic ribosomal protein eL6 family.
Belongs to the universal ribosomal protein uS12 family.
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
NADH-ubiquinone oxidoreductase 51kDa subunit
NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL
NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1
NADH-ubiquinone oxidoreductase 51kDa subunit FMN-binding
Belongs to the universal ribosomal protein uL1 family.
Polyphyly of Nucleariidae: genetic implications from Micronuclearia podoventralis.
The mitochondrial genome of Diphylleia rotans.
NADH:ubiquinone/plastoquinone oxidoreductase, chain 3
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.
Belongs to the complex I subunit 3 family.
CYTOCHROME C-TYPE BIOGENESIS PROTEIN CCMF
Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL
SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN
Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
28S RIBOSOMAL PROTEIN S12, MITOCHONDRIAL
37S RIBOSOMAL PROTEIN NAM9, MITOCHONDRIAL
Cytochrome c oxidase, subunit III, four-helix bundle
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Belongs to the cytochrome c oxidase subunit 3 family.
Heme-copper oxidase subunit III family profile
NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L
NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL
Belongs to the complex I 20 kDa subunit family.
NADH:ubiquinone oxidoreductase-like 20kDa subunit
a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Cytochrome b/b6 N-terminal region profile
Cytochrome b/b6 C-terminal region profile
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Belongs to the complex I subunit 4 family.
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL
Formate dehydrogenase/DMSO reductase, domains 1-3
Belongs to the complex I 75 kDa subunit family.
Cytochrome c oxidase-like, subunit I domain
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
Belongs to the heme-copper respiratory oxidase family.
Fumarate reductase/succinate dehydrogenase, transmembrane subunit
SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT
SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL
Fumarate reductase respiratory complex transmembrane subunits
The heme is bound between the two transmembrane subunits.
ligand shared with second transmembrane subunit
28S RIBOSOMAL PROTEIN S14, MITOCHONDRIAL
Belongs to the universal ribosomal protein uS14 family.
37S RIBOSOMAL PROTEIN S19, MITOCHONDRIAL
54S RIBOSOMAL PROTEIN L38, MITOCHONDRIAL
Belongs to the universal ribosomal protein uL14 family.
50S RIBOSOMAL PROTEIN L20, CHLOROPLASTIC
Belongs to the bacterial ribosomal protein bL20 family.
28S RIBOSOMAL PROTEIN S11, MITOCHONDRIAL
Cytochrome c oxidase subunit II-like, transmembrane region
Belongs to the cytochrome c oxidase subunit 2 family.
Cytochrome oxidase subunit II transmembrane region profile
Cytochrome oxidase subunit II copper A binding
Belongs to the complex I subunit 5 family.
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED
CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED
ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL
F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
NADH:ubiquinone oxidoreductase, 30kDa subunit
NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL
NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3
Belongs to the complex I 30 kDa subunit family.
NADH:ubiquinone oxidoreductase 30kDa subunit
NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ
Belongs to the complex I subunit 6 family.
Sec-independent protein translocase component
39S RIBOSOMAL PROTEIN L16, MITOCHONDRIAL
39S RIBOSOMAL PROTEIN L11, MITOCHONDRIAL
37S RIBOSOMAL PROTEIN SWS2, MITOCHONDRIAL
NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL
NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT
Belongs to the complex I 49 kDa subunit family.
Cytochrome c-type biogenesis protein CcmF C-terminal
Belongs to the complex I subunit 1 family.
NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL
NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL
Belongs to the complex I 23 kDa subunit family.
Belongs to the bacterial ribosomal protein bL34 family.