D3DJ41
type: Protein
reviewed: true
created: 2011-01-11
modified: 2023-06-28
version: 66
mnemonic: 2OCL_HYDTT
replaces: Q05KD8
citation: http://purl.uniprot.org/citations/17076668
citation: http://purl.uniprot.org/citations/20348262
citation: http://purl.uniprot.org/citations/21677850
citation: http://purl.uniprot.org/citations/14731279
recommended name: SIPF7F22065D8BB7B07
alternative name: SIP7A4457672504AE74
enzyme: http://purl.uniprot.org/enzyme/6.4.1.7
organism: http://purl.uniprot.org/taxonomy/608538
annotation: SIP45CECA70EEF531CD
annotation: SIPB2108A5A7EA999E2
annotation: SIPA3C9F6858FE20937
annotation: SIP0191021A4E4F2AEC
annotation: PRO_0000402797
annotation: SIP2A55A2B14ECF5EEB
annotation: SIP914F0C871F99E574
annotation: SIPE3D149CF4BC14DC3
annotation: SIP8F7F156E2F16858A
annotation: SIP6C4D72431D801D10
annotation: SIP4CAD1C5030D0D511
annotation: SIP23612E4208491511
annotation: SIPEC5C095E7968B127
annotation: SIPADE9BDE9A439CF29
annotation: SIPE64099CEC69D068A
annotation: SIP4F8E374E5921139E
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/92
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/436
classified with: http://purl.uniprot.org/keywords/460
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005737
classified with: GO_0034029
classified with: GO_0005524
classified with: GO_0046872
classified with: GO_0004736
classified with: GO_0008152
sequence: D3DJ41-1
proteome: Chromosome

D3DJ41-citation-17076668
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: CATALYTIC ACTIVITY
scope: SUBUNIT

D3DJ41-citation-20348262
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

DSM 6534 / IAM 12695 / TK-6
type: Strain

D3DJ41-citation-21677850
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

D3DJ41-citation-14731279
type: Citation Statement
scope: PROTEIN SEQUENCE OF 1-30
scope: SUBUNIT
scope: BIOTINYLATION

COG0511
type: Resource
database: eggNOG
comment: Bacteria

COG5016
type: Resource
database: eggNOG
comment: Bacteria

cd06850
type: Resource
database: CDD
comment: biotinyl_domain
signature sequence match: CDD cd06850 match 1

cd07937
type: Resource
database: CDD
comment: DRE_TIM_PC_TC_5S
signature sequence match: CDD cd07937 match 1

http://purl.uniprot.org/gene3d/3.20.20.70
type: Resource
database: Gene3D
comment: Aldolase class I
signature sequence match: Gene3D 3.20.20.70 match 1

IPR013785
type: Resource
database: InterPro
comment: Aldolase_TIM

IPR001882
type: Resource
database: InterPro
comment: Biotin_BS

IPR000089
type: Resource
database: InterPro
comment: Biotin_lipoyl

IPR003379
type: Resource
database: InterPro
comment: Carboxylase_cons_dom

IPR000891
type: Resource
database: InterPro
comment: PYR_CT

IPR011053
type: Resource
database: InterPro
comment: Single_hybrid_motif

PTHR45266
type: Resource
database: PANTHER
comment: OXALOACETATE DECARBOXYLASE ALPHA CHAIN
signature sequence match: PANTHER PTHR45266 match 1

PTHR45266:SF3
type: Resource
database: PANTHER
comment: OXALOACETATE DECARBOXYLASE ALPHA CHAIN
signature sequence match: PANTHER PTHR45266:SF3 match 1

PF00364
type: Resource
database: Pfam
comment: Biotin_lipoyl
signature sequence match: Pfam PF00364 match 1

PF00682
type: Resource
database: Pfam
comment: HMGL-like
signature sequence match: Pfam PF00682 match 1

PF02436
type: Resource
database: Pfam
comment: PYC_OADA
signature sequence match: Pfam PF02436 match 1

SSF51569
type: Resource
database: SUPFAM
comment: Aldolase
signature sequence match: SUPFAM SSF51569 match 1

SSF89000
type: Resource
database: SUPFAM
comment: post-HMGL domain-like
signature sequence match: SUPFAM SSF89000 match 1

SSF51230
type: Resource
database: SUPFAM
comment: Single hybrid motif
signature sequence match: SUPFAM SSF51230 match 1

PS00188
type: Resource
database: PROSITE
comment: BIOTIN
signature sequence match: PROSITE PS00188 match 1

PS50968
type: Resource
database: PROSITE
comment: BIOTINYL_LIPOYL
signature sequence match: PROSITE PS50968 match 1

PS50991
type: Resource
database: PROSITE
comment: PYR_CT
signature sequence match: PROSITE PS50991 match 1

SIPF7F22065D8BB7B07
type: Structured Name
full name: 2-oxoglutarate carboxylase large subunit
ec name: 6.4.1.7

SIP7A4457672504AE74
type: Structured Name
full name: 2-oxoglutarate carboxylase alpha subunit

cfiA
type: Gene
locus name: HTH_1392
locus name: Hydth_1382

SIPA3C9F6858FE20937
type: Subunit Annotation
comment: Heterohexadecamer of 8 large subunits and 8 small subunits.

SIP0191021A4E4F2AEC
type: PTM Annotation
comment: Biotinylated.

PRO_0000402797
type: Chain Annotation
comment: 2-oxoglutarate carboxylase large subunit
mass: 72546
range: 19196666812051758tt1tt652

19196666812051758tt1
type: Position
type: ExactPosition
position: 1
reference: D3DJ41-1

19196666812051758tt652
type: Position
type: ExactPosition
position: 652
reference: D3DJ41-1

SIP2A55A2B14ECF5EEB
type: Domain Extent Annotation
comment: Pyruvate carboxyltransferase
range: 19196666812051758tt26tt288

19196666812051758tt26
type: Position
type: ExactPosition
position: 26
reference: D3DJ41-1

19196666812051758tt288
type: Position
type: ExactPosition
position: 288
reference: D3DJ41-1

SIP914F0C871F99E574
type: Domain Extent Annotation
comment: Biotinyl-binding
range: 19196666812051758tt563tt643

19196666812051758tt563
type: Position
type: ExactPosition
position: 563
reference: D3DJ41-1

19196666812051758tt643
type: Position
type: ExactPosition
position: 643
reference: D3DJ41-1

19196666812051758tt34
type: Position
type: ExactPosition
position: 34
reference: D3DJ41-1

19196666812051758tt38
type: Position
type: ExactPosition
position: 38
reference: D3DJ41-1

19196666812051758tt35
type: Position
type: ExactPosition
position: 35
reference: D3DJ41-1

19196666812051758tt105
type: Position
type: ExactPosition
position: 105
reference: D3DJ41-1

SIP4CAD1C5030D0D511
type: Binding Site Annotation
comment: via carbamate group
ligand: SIP143CBB8E7D58A0D4
range: 19196666812051758tt196tt196

19196666812051758tt196
type: Position
type: ExactPosition
position: 196
reference: D3DJ41-1

19196666812051758tt227
type: Position
type: ExactPosition
position: 227
reference: D3DJ41-1

19196666812051758tt229
type: Position
type: ExactPosition
position: 229
reference: D3DJ41-1

19196666812051758tt362
type: Position
type: ExactPosition
position: 362
reference: D3DJ41-1

SIPE64099CEC69D068A
type: Modified Residue Annotation
comment: N6-carboxylysine
range: 19196666812051758tt196tt196

SIP4F8E374E5921139E
type: Modified Residue Annotation
comment: N6-biotinyllysine
range: 19196666812051758tt609tt609

19196666812051758tt609
type: Position
type: ExactPosition
position: 609
reference: D3DJ41-1

substrate

D3DJ41-1
type: Simple Sequence
modified: 2010-03-23
version: 1
mass: 72546
value: MQAVEIMEEIREKFKEFEKGGFRKKILITDLTPRDGQQCKLATRVRTDDLLPLCEAMDKVGFYAVEVWGGATYDVCLRYLKEDPWERLRRIKEVMPNTKLQMLFRGQNIVGYRPKSDKLVYKFVERAIKNGITVFRVFDALNDNRNIKTAVKAIKELGGEAHAEISYTRSPIHTYQKWIEYALEIAEMGADWLSFKDATGIIMPFETYAIIKGIKEATGGKLPVLLHNHDMSGTAIVNHMMAVLAGVDMLDTVLSPLAFGSSHPATESVVAMLEGTPFDTGIDMKKLDELAEIVKQIRKKYKKYETEYAGVNAKVLIHKIPGGMISNMVAQLIEANALDKIEEALEEVPNVERDLGHPPLLTPSSQIVGVQAVLNVISGERYKVITKEVRDYVEGKYGKPPGPISKELAEKILGPGKEPDFSIRAADLADPNDWDKAYEETKAILGREPTDEEVLLYALFPMQAKDFFVAREKGELHPEPVDELVETTEVKAGVVPGAAPVEFEIVYHGEKFKVKVEGVSAHQEPGKPRKYYIRVDGRLEEVQITPHVEAIPKGGPTPTAVQAEEKGIPKATQPGDATAPMPGRVVRVLVKEGDKVKEGQTVAIVEAMKMENEIHAPISGVVEKVFVKPGDNVTPDDALLRIKHIEEEVSYG

http://purl.uniprot.org/uniprot/D3DJ41#attribution-40209258E3EB5B27C36FDF953627F648
manual: true
evidence: ECO_0000250
source: P11498

http://purl.uniprot.org/uniprot/D3DJ41#attribution-CCACE84CD7B215ACB681534284FB322B
manual: true
evidence: ECO_0000250
source: Q58628

http://purl.uniprot.org/uniprot/D3DJ41#attribution-A151EE2D7ED0C19A5F9E5FF9943128F3
manual: true
evidence: ECO_0000255
source: PRU01066

http://purl.uniprot.org/uniprot/D3DJ41#attribution-02352B8D03D686751CAD5E0A597CE603
manual: true
evidence: ECO_0000255
source: PRU01151

http://purl.uniprot.org/uniprot/D3DJ41#attribution-49E8B522B263F837D475DCC303AF5A9C
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/14731279

http://purl.uniprot.org/uniprot/D3DJ41#attribution-21710F811968D62E7F2D6DF1D52D69B9
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/17076668

http://purl.uniprot.org/uniprot/D3DJ41#attribution-DA5536FB78502EA924E2680719324298
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/14731279

http://purl.uniprot.org/uniprot/D3DJ41#attribution-AC2149FCC6D6517AAE32E4D3E2840D2A
manual: true
evidence: ECO_0000305

http://purl.uniprot.org/uniprot/D3DJ41#attribution-FC1C6E45A933B1156D85BD9611EAE717
manual: true
evidence: ECO_0000312
source: BAF34932.1

http://purl.uniprot.org/uniprot/D3DJ41#attribution-FEDADE55288DB2A3DF0B0BCC97DD161A
manual: true
evidence: ECO_0000312
source: BAI69843.1

D3DJ42
type: Protein
reviewed: true
created: 2011-01-11
modified: 2023-09-13
version: 80
mnemonic: 2OCS_HYDTT
replaces: Q05KD9
citation: http://purl.uniprot.org/citations/17076668
citation: http://purl.uniprot.org/citations/20348262
citation: http://purl.uniprot.org/citations/21677850
citation: http://purl.uniprot.org/citations/14731279
recommended name: SIPD3BD833CC56A6117
alternative name: SIPF252500CFFE81B05
enzyme: http://purl.uniprot.org/enzyme/6.4.1.7
organism: http://purl.uniprot.org/taxonomy/608538
annotation: SIPE5CD517E56D4D68F
annotation: SIPF350F4439B03E938
annotation: SIP216BC40B1A3834DB
annotation: PRO_0000402798
annotation: SIPA102BB69F1559851
annotation: SIP97B00DFC374DCBFD
annotation: SIP3D011E7E6F541F3C
annotation: SIP15A0D1C11F505602
annotation: SIP5EB0AA9C6D720DDE
annotation: SIPE9C37EEB32A512E3
annotation: SIP0CDC61CB569844B1
annotation: SIPDA9CE9692372FBB0
annotation: SIPCD643E1F8662B800
annotation: SIP0A7672ABF990783D
annotation: SIP4ADE86A60C9AC2E5
annotation: SIPA538FCAB61A00C93
annotation: SIP8A6B5A4A43FB1328
annotation: SIP150204436504B30F
annotation: SIP3BBF3B8EBCA78D5A
annotation: SIPF3740599C0A66855
annotation: SIP4EED14ED8F4CA7CA
annotation: SIP4557EFA07046C00C
annotation: SIP3C232960723F8E3B
annotation: SIPA7FBB7576FA41588
annotation: SIP507BD051A08E6CE4
annotation: SIP94C6161535930732
annotation: SIP2F1CD597ABAA589A
annotation: SIP11A395B221B6856E
annotation: SIP96780F382BF3A126
annotation: SIPFC68042D46A6EF7D
annotation: SIP7967CFFFE890E04E
annotation: SIP8626E04FD8A4A6D5
annotation: SIP13EA513C988F7A14
annotation: SIPEA97EAF8519252CC
annotation: SIP369E752FE8941934
annotation: SIPBD3849A2FFC7612A
annotation: SIP4A0186883643A3E1
annotation: SIP74E9090BFFE52EED
annotation: SIPC7F41B2629836CF1
annotation: SIP142842ACFA70C511
annotation: SIPFBA15E7D0EA74FA7
annotation: SIP0C465FED3F506245
annotation: SIPADC491420AF46C24
annotation: SIP73AA89057237BE48
annotation: SIP0A66270C00D395E5
annotation: SIP6D7C49CC3F03B3C8
annotation: SIPCD082946819731BA
annotation: SIP7A1722C1C3829EC7
annotation: SIP4345B507F5D95AFE
annotation: SIP2FFB40C9FB6552A6
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/92
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/436
classified with: http://purl.uniprot.org/keywords/460
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0034029
classified with: GO_0005524
classified with: GO_0046872
sequence: D3DJ42-1
proteome: Chromosome

D3DJ42-citation-17076668
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: CATALYTIC ACTIVITY
scope: SUBUNIT

D3DJ42-citation-20348262
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

DSM 6534 / IAM 12695 / TK-6
type: Strain

D3DJ42-citation-21677850
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

D3DJ42-citation-14731279
type: Citation Statement
scope: PROTEIN SEQUENCE OF 1-30
scope: SUBUNIT

7KBL
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.30
chain sequence mapping: PDB 7KBL tt1tt472

PDB 7KBL tt1tt472
chain: A/B=1-472

7KC7
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.20
chain sequence mapping: PDB 7KC7 tt1tt472

PDB 7KC7 tt1tt472
chain: A/B=1-472

7KCT
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.02
chain sequence mapping: PDB 7KCT tt1tt472

PDB 7KCT tt1tt472
chain: A/B=1-472

COG0439
type: Resource
database: eggNOG
comment: Bacteria

http://purl.uniprot.org/gene3d/3.30.470.20
type: Resource
database: Gene3D
comment: ATP-grasp fold, B domain
signature sequence match: Gene3D 3.30.470.20 match 1

IPR004549
type: Resource
database: InterPro
comment: Acetyl_CoA_COase_biotin_COase

IPR011761
type: Resource
database: InterPro
comment: ATP-grasp

IPR005481
type: Resource
database: InterPro
comment: BC-like_N

IPR011764
type: Resource
database: InterPro
comment: Biotin_carboxylation_dom

IPR005482
type: Resource
database: InterPro
comment: Biotin_COase_C

IPR005479
type: Resource
database: InterPro
comment: CbamoylP_synth_lsu-like_ATP-bd

IPR016185
type: Resource
database: InterPro
comment: PreATP-grasp_dom_sf

IPR011054
type: Resource
database: InterPro
comment: Rudment_hybrid_motif

TIGR00514
type: Resource
database: NCBIfam
comment: accC
signature sequence match: NCBIfam TIGR00514 match 1

PTHR48095:SF1
type: Resource
database: PANTHER
comment: BIOTIN CARBOXYLASE
signature sequence match: PANTHER PTHR48095:SF1 match 1

PTHR48095
type: Resource
database: PANTHER
comment: PYRUVATE CARBOXYLASE SUBUNIT A
signature sequence match: PANTHER PTHR48095 match 1

PF02785
type: Resource
database: Pfam
comment: Biotin_carb_C
signature sequence match: Pfam PF02785 match 1

PF00289
type: Resource
database: Pfam
comment: Biotin_carb_N
signature sequence match: Pfam PF00289 match 1

PF02786
type: Resource
database: Pfam
comment: CPSase_L_D2
signature sequence match: Pfam PF02786 match 1

SM00878
type: Resource
database: SMART
comment: Biotin_carb_C
signature sequence match: SMART SM00878 match 1

SSF56059
type: Resource
database: SUPFAM
comment: Glutathione synthetase ATP-binding domain-like
signature sequence match: SUPFAM SSF56059 match 1

SSF52440
type: Resource
database: SUPFAM
comment: PreATP-grasp domain
signature sequence match: SUPFAM SSF52440 match 1

SSF51246
type: Resource
database: SUPFAM
comment: Rudiment single hybrid motif
signature sequence match: SUPFAM SSF51246 match 1

PS50975
type: Resource
database: PROSITE
comment: ATP_GRASP
signature sequence match: PROSITE PS50975 match 1

PS50979
type: Resource
database: PROSITE
comment: BC
signature sequence match: PROSITE PS50979 match 1

PS00866
type: Resource
database: PROSITE
comment: CPSASE_1
signature sequence match: PROSITE PS00866 match 1

PS00867
type: Resource
database: PROSITE
comment: CPSASE_2
signature sequence match: PROSITE PS00867 match 1

SIPD3BD833CC56A6117
type: Structured Name
full name: 2-oxoglutarate carboxylase small subunit
ec name: 6.4.1.7

SIPF252500CFFE81B05
type: Structured Name
full name: 2-oxoglutarate carboxylase beta subunit

cfiB
type: Gene
locus name: HTH_1393
locus name: Hydth_1383

SIP216BC40B1A3834DB
type: Subunit Annotation
comment: Heterohexadecamer of 8 large subunits and 8 small subunits.

PRO_0000402798
type: Chain Annotation
comment: 2-oxoglutarate carboxylase small subunit
mass: 53386
range: 19196666812052014tt1tt472

19196666812052014tt1
type: Position
type: ExactPosition
position: 1
reference: D3DJ42-1

19196666812052014tt472
type: Position
type: ExactPosition
position: 472
reference: D3DJ42-1

SIPA102BB69F1559851
type: Domain Extent Annotation
comment: Biotin carboxylation
range: 19196666812052014tt1tt445

19196666812052014tt445
type: Position
type: ExactPosition
position: 445
reference: D3DJ42-1

SIP97B00DFC374DCBFD
type: Domain Extent Annotation
comment: ATP-grasp
range: 19196666812052014tt119tt316

19196666812052014tt119
type: Position
type: ExactPosition
position: 119
reference: D3DJ42-1

19196666812052014tt316
type: Position
type: ExactPosition
position: 316
reference: D3DJ42-1

19196666812052014tt291
type: Position
type: ExactPosition
position: 291
reference: D3DJ42-1

19196666812052014tt115
type: Position
type: ExactPosition
position: 115
reference: D3DJ42-1

19196666812052014tt199
type: Position
type: ExactPosition
position: 199
reference: D3DJ42-1

19196666812052014tt3
type: Position
type: ExactPosition
position: 3
reference: D3DJ42-1

19196666812052014tt7
type: Position
type: ExactPosition
position: 7
reference: D3DJ42-1

19196666812052014tt11
type: Position
type: ExactPosition
position: 11
reference: D3DJ42-1

19196666812052014tt23
type: Position
type: ExactPosition
position: 23
reference: D3DJ42-1

19196666812052014tt27
type: Position
type: ExactPosition
position: 27
reference: D3DJ42-1

19196666812052014tt32
type: Position
type: ExactPosition
position: 32
reference: D3DJ42-1

19196666812052014tt34
type: Position
type: ExactPosition
position: 34
reference: D3DJ42-1

19196666812052014tt36
type: Position
type: ExactPosition
position: 36
reference: D3DJ42-1

19196666812052014tt40
type: Position
type: ExactPosition
position: 40
reference: D3DJ42-1

19196666812052014tt44
type: Position
type: ExactPosition
position: 44
reference: D3DJ42-1

19196666812052014tt45
type: Position
type: ExactPosition
position: 45
reference: D3DJ42-1

19196666812052014tt50
type: Position
type: ExactPosition
position: 50
reference: D3DJ42-1

19196666812052014tt57
type: Position
type: ExactPosition
position: 57
reference: D3DJ42-1

19196666812052014tt60
type: Position
type: ExactPosition
position: 60
reference: D3DJ42-1

19196666812052014tt62
type: Position
type: ExactPosition
position: 62
reference: D3DJ42-1

19196666812052014tt72
type: Position
type: ExactPosition
position: 72
reference: D3DJ42-1

19196666812052014tt76
type: Position
type: ExactPosition
position: 76
reference: D3DJ42-1

19196666812052014tt78
type: Position
type: ExactPosition
position: 78
reference: D3DJ42-1

19196666812052014tt83
type: Position
type: ExactPosition
position: 83
reference: D3DJ42-1

19196666812052014tt86
type: Position
type: ExactPosition
position: 86
reference: D3DJ42-1

19196666812052014tt88
type: Position
type: ExactPosition
position: 88
reference: D3DJ42-1

19196666812052014tt96
type: Position
type: ExactPosition
position: 96
reference: D3DJ42-1

19196666812052014tt100
type: Position
type: ExactPosition
position: 100
reference: D3DJ42-1

19196666812052014tt104
type: Position
type: ExactPosition
position: 104
reference: D3DJ42-1

19196666812052014tt106
type: Position
type: ExactPosition
position: 106
reference: D3DJ42-1

19196666812052014tt111
type: Position
type: ExactPosition
position: 111
reference: D3DJ42-1

19196666812052014tt124
type: Position
type: ExactPosition
position: 124
reference: D3DJ42-1

19196666812052014tt134
type: Position
type: ExactPosition
position: 134
reference: D3DJ42-1

19196666812052014tt136
type: Position
type: ExactPosition
position: 136
reference: D3DJ42-1

19196666812052014tt140
type: Position
type: ExactPosition
position: 140
reference: D3DJ42-1

19196666812052014tt150
type: Position
type: ExactPosition
position: 150
reference: D3DJ42-1

19196666812052014tt152
type: Position
type: ExactPosition
position: 152
reference: D3DJ42-1

19196666812052014tt158
type: Position
type: ExactPosition
position: 158
reference: D3DJ42-1

19196666812052014tt159
type: Position
type: ExactPosition
position: 159
reference: D3DJ42-1

19196666812052014tt163
type: Position
type: ExactPosition
position: 163
reference: D3DJ42-1

19196666812052014tt166
type: Position
type: ExactPosition
position: 166
reference: D3DJ42-1

19196666812052014tt172
type: Position
type: ExactPosition
position: 172
reference: D3DJ42-1

19196666812052014tt173
type: Position
type: ExactPosition
position: 173
reference: D3DJ42-1

19196666812052014tt191
type: Position
type: ExactPosition
position: 191
reference: D3DJ42-1

19196666812052014tt196
type: Position
type: ExactPosition
position: 196
reference: D3DJ42-1

19196666812052014tt200
type: Position
type: ExactPosition
position: 200
reference: D3DJ42-1

19196666812052014tt206
type: Position
type: ExactPosition
position: 206
reference: D3DJ42-1

19196666812052014tt214
type: Position
type: ExactPosition
position: 214
reference: D3DJ42-1

19196666812052014tt220
type: Position
type: ExactPosition
position: 220
reference: D3DJ42-1

19196666812052014tt227
type: Position
type: ExactPosition
position: 227
reference: D3DJ42-1

19196666812052014tt235
type: Position
type: ExactPosition
position: 235
reference: D3DJ42-1

19196666812052014tt242
type: Position
type: ExactPosition
position: 242
reference: D3DJ42-1

19196666812052014tt248
type: Position
type: ExactPosition
position: 248
reference: D3DJ42-1

19196666812052014tt264
type: Position
type: ExactPosition
position: 264
reference: D3DJ42-1

19196666812052014tt269
type: Position
type: ExactPosition
position: 269
reference: D3DJ42-1

19196666812052014tt277
type: Position
type: ExactPosition
position: 277
reference: D3DJ42-1

19196666812052014tt283
type: Position
type: ExactPosition
position: 283
reference: D3DJ42-1

19196666812052014tt289
type: Position
type: ExactPosition
position: 289
reference: D3DJ42-1

19196666812052014tt296
type: Position
type: ExactPosition
position: 296
reference: D3DJ42-1

19196666812052014tt303
type: Position
type: ExactPosition
position: 303
reference: D3DJ42-1

19196666812052014tt307
type: Position
type: ExactPosition
position: 307
reference: D3DJ42-1

19196666812052014tt315
type: Position
type: ExactPosition
position: 315
reference: D3DJ42-1

19196666812052014tt324
type: Position
type: ExactPosition
position: 324
reference: D3DJ42-1

19196666812052014tt326
type: Position
type: ExactPosition
position: 326
reference: D3DJ42-1

19196666812052014tt331
type: Position
type: ExactPosition
position: 331
reference: D3DJ42-1

19196666812052014tt341
type: Position
type: ExactPosition
position: 341
reference: D3DJ42-1

19196666812052014tt343
type: Position
type: ExactPosition
position: 343
reference: D3DJ42-1

19196666812052014tt345
type: Position
type: ExactPosition
position: 345
reference: D3DJ42-1

19196666812052014tt356
type: Position
type: ExactPosition
position: 356
reference: D3DJ42-1

19196666812052014tt358
type: Position
type: ExactPosition
position: 358
reference: D3DJ42-1

19196666812052014tt365
type: Position
type: ExactPosition
position: 365
reference: D3DJ42-1

19196666812052014tt369
type: Position
type: ExactPosition
position: 369
reference: D3DJ42-1

19196666812052014tt379
type: Position
type: ExactPosition
position: 379
reference: D3DJ42-1

19196666812052014tt381
type: Position
type: ExactPosition
position: 381
reference: D3DJ42-1

19196666812052014tt384
type: Position
type: ExactPosition
position: 384
reference: D3DJ42-1

19196666812052014tt394
type: Position
type: ExactPosition
position: 394
reference: D3DJ42-1

19196666812052014tt395
type: Position
type: ExactPosition
position: 395
reference: D3DJ42-1

19196666812052014tt408
type: Position
type: ExactPosition
position: 408
reference: D3DJ42-1

19196666812052014tt418
type: Position
type: ExactPosition
position: 418
reference: D3DJ42-1

19196666812052014tt426
type: Position
type: ExactPosition
position: 426
reference: D3DJ42-1

19196666812052014tt428
type: Position
type: ExactPosition
position: 428
reference: D3DJ42-1

19196666812052014tt431
type: Position
type: ExactPosition
position: 431
reference: D3DJ42-1

19196666812052014tt439
type: Position
type: ExactPosition
position: 439
reference: D3DJ42-1

19196666812052014tt442
type: Position
type: ExactPosition
position: 442
reference: D3DJ42-1

19196666812052014tt444
type: Position
type: ExactPosition
position: 444
reference: D3DJ42-1

19196666812052014tt447
type: Position
type: ExactPosition
position: 447
reference: D3DJ42-1

D3DJ42-1
type: Simple Sequence
modified: 2010-03-23
version: 1
mass: 53386
value: MFKKVLVANRGEIACRVIRACKELGIQTVAIYNEIESTARHVKMADEAYMIGVNPLDTYLNAERIVDLALEVGAEAIHPGYGFLAENEHFARLCEEKGITFIGPHWKVIELMGDKARSKEVMKRAGVPTVPGSDGILKDVEEAKRIAKEIGYPVLLKASAGGGGRGIRICRNEEELVRNYENAYNEAVKAFGRGDLLLEKYIENPKHIEFQVLGDKYGNVIHLGERDCSIQRRNQKLVEIAPSLLLTPEQREYYGSLVVKAAKEIGYYSAGTMEFIADEKGNLYFIEMNTRIQVEHPVTEMITGVDIVKWQIRIAAGERLRYSQEDIRFNGYSIECRINAEDPKKGFAPSIGTIERYYVPGGFGIRVEHASSKGYEITPYYDSLIAKLIVWAPLWEVAVDRMRSALETYEISGVKTTIPLLINIMKDKDFRDGKFTTRYLEEHPHVFDYAEHRDKEDFVAFISAVIASYHGL

http://purl.uniprot.org/uniprot/D3DJ42#attribution-7CE83DF96DD03479A64CCD1ECC418CAE
manual: true
evidence: ECO_0000250
source: O27939

http://purl.uniprot.org/uniprot/D3DJ42#attribution-512AAD3C2F3032709BACEC49B88101C2
manual: true
evidence: ECO_0000250
source: P24182

http://purl.uniprot.org/uniprot/D3DJ42#attribution-18151006A0CE7A38D8D1B11EC1DFD9E2
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/D3DJ42#attribution-E6C6B3EA7A66695F36FACB2EFCB27D80
manual: true
evidence: ECO_0000255
source: PRU00409

http://purl.uniprot.org/uniprot/D3DJ42#attribution-49E8B522B263F837D475DCC303AF5A9C
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/14731279

http://purl.uniprot.org/uniprot/D3DJ42#attribution-21710F811968D62E7F2D6DF1D52D69B9
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/17076668

http://purl.uniprot.org/uniprot/D3DJ42#attribution-DA5536FB78502EA924E2680719324298
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/14731279

http://purl.uniprot.org/uniprot/D3DJ42#attribution-AC2149FCC6D6517AAE32E4D3E2840D2A
manual: true
evidence: ECO_0000305

http://purl.uniprot.org/uniprot/D3DJ42#attribution-7FEA5BAFA43D0A8F12D7A36695828E50
manual: true
evidence: ECO_0000312
source: BAF34931.1

http://purl.uniprot.org/uniprot/D3DJ42#attribution-1413DD54685BFEC0100E2D170C39F30E
manual: true
evidence: ECO_0000312
source: BAI69844.1

O67781
type: Protein
reviewed: true
created: 2000-05-30
modified: 2023-06-28
version: 121
mnemonic: AAPAT_AQUAE
old mnemonic: AAT_AQUAE
citation: http://purl.uniprot.org/citations/9537320
recommended name: SIPE2E7D9663E7DCEC8
alternative name: SIPAF5E5BCE49FA0002
enzyme: http://purl.uniprot.org/enzyme/2.6.1.1
enzyme: http://purl.uniprot.org/enzyme/2.6.1.78
organism: http://purl.uniprot.org/taxonomy/224324
annotation: SIP2ABAB98FFDAB6ED5
annotation: SIPF91C92A74A8C6BDB
annotation: SIP74878930B3208B2E
annotation: SIP0BE4683B65C84143
annotation: SIPE7A6B97FDD7203F5
annotation: SIPD954F81BA70C7819
annotation: SIP46184AF1933EA6DA
annotation: PRO_0000123833
annotation: SIP8B53B6AB3E9B6EF3
annotation: SIPB7EE93EDF613416E
annotation: SIPCFE02336C4A9871F
annotation: SIP8439839C89070095
annotation: SIP997FFFA2AFC2F284
annotation: SIP03CCB29D070AB301
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/32
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/663
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005737
classified with: GO_0033853
classified with: GO_0004069
classified with: GO_0030170
classified with: GO_0009058
sequence: O67781-1
proteome: Chromosome

O67781-citation-9537320
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

VF5
type: Strain

COG0436
type: Resource
database: eggNOG
comment: Bacteria

cd00609
type: Resource
database: CDD
comment: AAT_like
signature sequence match: CDD cd00609 match 1

http://purl.uniprot.org/gene3d/3.90.1150.10
type: Resource
database: Gene3D
comment: Aspartate Aminotransferase, domain 1
signature sequence match: Gene3D 3.90.1150.10 match 1

http://purl.uniprot.org/gene3d/3.40.640.10
type: Resource
database: Gene3D
comment: Type I PLP-dependent aspartate aminotransferase-like (Major domain)
signature sequence match: Gene3D 3.40.640.10 match 1

IPR004839
type: Resource
database: InterPro
comment: Aminotransferase_I/II

IPR015424
type: Resource
database: InterPro
comment: PyrdxlP-dep_Trfase

IPR015421
type: Resource
database: InterPro
comment: PyrdxlP-dep_Trfase_major

IPR015422
type: Resource
database: InterPro
comment: PyrdxlP-dep_Trfase_small

PTHR46383
type: Resource
database: PANTHER
comment: ASPARTATE AMINOTRANSFERASE
signature sequence match: PANTHER PTHR46383 match 1

PTHR46383:SF1
type: Resource
database: PANTHER
comment: ASPARTATE AMINOTRANSFERASE
signature sequence match: PANTHER PTHR46383:SF1 match 1

PF00155
type: Resource
database: Pfam
comment: Aminotran_1_2
signature sequence match: Pfam PF00155 match 1

PR00753
type: Resource
database: PRINTS
comment: ACCSYNTHASE

SSF53383
type: Resource
database: SUPFAM
comment: PLP-dependent transferases
signature sequence match: SUPFAM SSF53383 match 1

SIPE2E7D9663E7DCEC8
type: Structured Name
full name: Probable aspartate/prephenate aminotransferase
short name: AspAT / PAT
ec name: 2.6.1.1
ec name: 2.6.1.78

SIPAF5E5BCE49FA0002
type: Structured Name
full name: Transaminase A

aspC
type: Gene
locus name: aq_1969

SIP2ABAB98FFDAB6ED5
type: Function Annotation
comment: Catalyzes the reversible conversion of aspartate and 2-oxoglutarate to glutamate and oxaloacetate. Can also transaminate prephenate in the presence of aspartate.

SIPE7A6B97FDD7203F5
type: Subunit Annotation
comment: Homodimer.

SIP46184AF1933EA6DA
type: Similarity Annotation
comment: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

PRO_0000123833
type: Chain Annotation
comment: Probable aspartate/prephenate aminotransferase
mass: 43777
range: 22296133937672494tt1tt394

22296133937672494tt1
type: Position
type: ExactPosition
position: 1
reference: O67781-1

22296133937672494tt394
type: Position
type: ExactPosition
position: 394
reference: O67781-1

22296133937672494tt40
type: Position
type: ExactPosition
position: 40
reference: O67781-1

22296133937672494tt126
type: Position
type: ExactPosition
position: 126
reference: O67781-1

22296133937672494tt176
type: Position
type: ExactPosition
position: 176
reference: O67781-1

22296133937672494tt370
type: Position
type: ExactPosition
position: 370
reference: O67781-1

SIP997FFFA2AFC2F284
type: Site Annotation
comment: Important for prephenate aminotransferase activity
range: 22296133937672494tt13tt13

22296133937672494tt13
type: Position
type: ExactPosition
position: 13
reference: O67781-1

SIP03CCB29D070AB301
type: Modified Residue Annotation
comment: N6-(pyridoxal phosphate)lysine
range: 22296133937672494tt239tt239

22296133937672494tt239
type: Position
type: ExactPosition
position: 239
reference: O67781-1

O67781-1
type: Simple Sequence
modified: 1998-08-01
version: 1
mass: 43777
value: MRKGLASRVSHLKPSPTLTITAKAKELRAKGVDVIGFGAGEPDFDTPDFIKEACIRALREGKTKYAPSAGIPELREAIAEKLLKENKVEYKPSEIVVSAGAKMVLFLIFMAILDEGDEVLLPSPYWVTYPEQIRFFGGVPVEVPLKKEKGFQLSLEDVKEKVTERTKAIVINSPNNPTGAVYEEEELKKIAEFCVERGIFIISDECYEYFVYGDAKFVSPASFSDEVKNITFTVNAFSKSYSMTGWRIGYVACPEEYAKVIASLNSQSVSNVTTFAQYGALEALKNPKSKDFVNEMRNAFERRRDTAVEELSKIPGMDVVKPEGAFYIFPDFSAYAEKLGGDVKLSEFLLEKAKVAVVPGSAFGAPGFLRLSYALSEERLVEGIRRIKKALEEI

http://purl.uniprot.org/uniprot/O67781#attribution-D1F2CBC6367FFB5EC542AB34F29E0327
manual: true
evidence: ECO_0000250
source: P00509

http://purl.uniprot.org/uniprot/O67781#attribution-1179831BD0A6F7F9DD0412EF27BBA076
manual: true
evidence: ECO_0000250
source: Q56232

http://purl.uniprot.org/uniprot/O67781#attribution-888D80D2865183B81CAC964D4FDE59BF
manual: true
evidence: ECO_0000305

O66728
type: Protein
reviewed: true
created: 2019-07-03
modified: 2023-06-28
version: 131
mnemonic: AATNT_AQUAE
citation: http://purl.uniprot.org/citations/9537320
citation: http://purl.uniprot.org/citations/11701927
citation: http://purl.uniprot.org/citations/15295603
citation: http://purl.uniprot.org/citations/25914059
recommended name: SIPFA15422CA0128D28
alternative name: SIP8ED6CA6C8EBC834F
enzyme: http://purl.uniprot.org/enzyme/2.7.7.-
organism: http://purl.uniprot.org/taxonomy/224324
annotation: SIPA8E751C6C6CEE02B
annotation: SIPA0C6B3A9347A62FB
annotation: SIPD71E9E105182564A
annotation: SIP99CDB5D1005F691F
annotation: SIPCE6E7FA5CBD44362
annotation: SIPE79BFAAD799B980D
annotation: PRO_0000447563
annotation: SIP0AABFE1A1BF11827
annotation: SIPE3DF0377A3213C24
annotation: SIP33BA7EAD2562285C
annotation: SIP34A3F6637D45F29E
annotation: SIP7E0771EC2FE22770
annotation: SIP744806B1451EE8CA
annotation: SIP11D2D32CAF3175C4
annotation: SIP319E509B697C57AF
annotation: SIPE1E92AF500097B64
annotation: SIP9FADD9F1331D9994
annotation: SIP5DB9840CBCCB5269
annotation: SIP26035143A2CD8FDF
annotation: SIP3DDCB1460557CCF5
annotation: SIP8A63017BE0F3AF73
annotation: SIPAB388CB7BE8271B9
annotation: SIP076CBAC07BC066A0
annotation: SIP2CAA9509FF0FC6B2
annotation: SIP5F96CEAC002AAD95
annotation: SIPE23D5F2327699EC6
annotation: SIP8530B2ED720F33D5
annotation: SIP64D1E15E2C04D2D6
annotation: SIPD9085BE6281FBD29
annotation: SIP6FA0326E79A3E504
annotation: SIPB2EF8386C889ECAD
annotation: SIP7E9C5EA7EE311512
annotation: SIP27FD829DC16B9C3D
annotation: SIPB18D6609F72F820E
annotation: SIP9D831A689920942B
annotation: SIP3C0AE7EEC86A7216
annotation: SIP619D0C84D6B1665C
annotation: SIP0BD1A82F22EA955E
annotation: SIP942550AE63085CDB
annotation: SIP844EFFD936B17BEC
annotation: SIP631F8D5AD8165758
annotation: SIPA59FC67290D9C52B
annotation: SIP4287B07C1BD835B9
annotation: SIPDC7074644E0903A6
annotation: SIP6CCF43B65562CA7C
annotation: SIP5FB4215E9AABBE0A
annotation: SIPE51BE301A1B0FCF8
annotation: SIPA5DB76888F107B57
annotation: SIPD3E7CC2917BA2032
annotation: SIP3E4D207B79172573
annotation: SIPB2A08F1FCA3C0152
annotation: SIPE2AE82507B38A4CA
annotation: SIP2E6DBE6B6F2A3EB0
annotation: SIPA69F3D1CED9CD55F
annotation: SIP987800D9442A8CEC
annotation: SIP6347EFEE97DA1B4D
annotation: SIPB18DAAA83822AA16
annotation: SIPC22170E6020843CF
annotation: SIP1CC64C9F8F8606AF
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/129
classified with: http://purl.uniprot.org/keywords/460
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/548

O66728-citation-9537320
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

VF5
type: Strain

O66728-citation-11701927
type: Citation Statement
scope: FUNCTION
scope: CATALYTIC ACTIVITY

O66728-citation-15295603
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 443-824 IN COMPLEX WITH ATP ANALOG
scope: DOMAIN

O66728-citation-25914059
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 428-824 IN COMPLEXES WITH ATP; CTP; TRNA AND MAGNESIUM
scope: FUNCTION
scope: CATALYTIC ACTIVITY
scope: COFACTOR
scope: BIOPHYSICOCHEMICAL PROPERTIES
scope: DOMAIN

1VFG
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.80
chain sequence mapping: PDB 1VFG tt443tt824

PDB 1VFG tt443tt824
chain: A/B=443-824

4WBY
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 1.50
chain sequence mapping: PDB 4WBY tt428tt824

PDB 4WBY tt428tt824
chain: A=428-824

4WBZ
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 3.30
chain sequence mapping: PDB 4WBZ tt443tt824

PDB 4WBZ tt443tt824
chain: A/B=443-824

4WC0
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 3.10
chain sequence mapping: PDB 4WC0 tt443tt824

PDB 4WC0 tt443tt824
chain: A/B=443-824

4WC1
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 3.10
chain sequence mapping: PDB 4WC1 tt443tt824

PDB 4WC1 tt443tt824
chain: A/B=443-824

4WC2
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.80
chain sequence mapping: PDB 4WC2 tt443tt824

PDB 4WC2 tt443tt824
chain: A=443-824

4WC3
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 3.10
chain sequence mapping: PDB 4WC3 tt443tt824

PDB 4WC3 tt443tt824
chain: A=443-824

4WC4
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 3.50
chain sequence mapping: PDB 4WC4 tt443tt824

PDB 4WC4 tt443tt824
chain: A=443-824

4WC5
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 3.41
chain sequence mapping: PDB 4WC5 tt443tt824

PDB 4WC5 tt443tt824
chain: A=443-824

4WC6
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 3.41
chain sequence mapping: PDB 4WC6 tt443tt824

PDB 4WC6 tt443tt824
chain: A=443-824

4WC7
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 3.10
chain sequence mapping: PDB 4WC7 tt443tt824

PDB 4WC7 tt443tt824
chain: A=443-824

4X0A
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 3.50
chain sequence mapping: PDB 4X0A tt443tt824

PDB 4X0A tt443tt824
chain: A=443-824

4X0B
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 3.20
chain sequence mapping: PDB 4X0B tt443tt824

PDB 4X0B tt443tt824
chain: A=443-824

COG0517
type: Resource
database: eggNOG
comment: Bacteria

COG0617
type: Resource
database: eggNOG
comment: Bacteria

COG0618
type: Resource
database: eggNOG
comment: Bacteria

cd02205
type: Resource
database: CDD
comment: CBS_pair_SF
signature sequence match: CDD cd02205 match 1

cd05398
type: Resource
database: CDD
comment: NT_ClassII-CCAase
signature sequence match: CDD cd05398 match 1

http://purl.uniprot.org/gene3d/3.30.460.10
type: Resource
database: Gene3D
comment: Beta Polymerase, domain 2
signature sequence match: Gene3D 3.30.460.10 match 1

http://purl.uniprot.org/gene3d/3.10.580.10
type: Resource
database: Gene3D
comment: CBS-domain
signature sequence match: Gene3D 3.10.580.10 match 1
signature sequence match: Gene3D 3.10.580.10 match 2

http://purl.uniprot.org/gene3d/1.10.3090.10
type: Resource
database: Gene3D
comment: cca-adding enzyme, domain 2
signature sequence match: Gene3D 1.10.3090.10 match 1

http://purl.uniprot.org/gene3d/3.90.1640.10
type: Resource
database: Gene3D
comment: inorganic pyrophosphatase (n-terminal core)
signature sequence match: Gene3D 3.90.1640.10 match 1

IPR000644
type: Resource
database: InterPro
comment: CBS_dom

IPR046342
type: Resource
database: InterPro
comment: CBS_dom_sf

IPR038763
type: Resource
database: InterPro
comment: DHH_sf

IPR003156
type: Resource
database: InterPro
comment: DHHA1_dom

IPR043519
type: Resource
database: InterPro
comment: NT_sf

IPR002646
type: Resource
database: InterPro
comment: PolA_pol_head_dom

PTHR47788:SF1
type: Resource
database: PANTHER
comment: A-ADDING TRNA NUCLEOTIDYLTRANSFERASE
signature sequence match: PANTHER PTHR47788:SF1 match 1

PTHR47788
type: Resource
database: PANTHER
comment: POLYA POLYMERASE
signature sequence match: PANTHER PTHR47788 match 1

PF00571
type: Resource
database: Pfam
comment: CBS
signature sequence match: Pfam PF00571 match 1
signature sequence match: Pfam PF00571 match 2

PF02272
type: Resource
database: Pfam
comment: DHHA1
signature sequence match: Pfam PF02272 match 1

PF01743
type: Resource
database: Pfam
comment: PolyA_pol
signature sequence match: Pfam PF01743 match 1

SM00116
type: Resource
database: SMART
comment: CBS
signature sequence match: SMART SM00116 match 1
signature sequence match: SMART SM00116 match 2

SSF54631
type: Resource
database: SUPFAM
comment: CBS-domain pair
signature sequence match: SUPFAM SSF54631 match 1

SSF64182
type: Resource
database: SUPFAM
comment: DHH phosphoesterases
signature sequence match: SUPFAM SSF64182 match 1

SSF81301
type: Resource
database: SUPFAM
comment: Nucleotidyltransferase
signature sequence match: SUPFAM SSF81301 match 1

SSF81891
type: Resource
database: SUPFAM
comment: Poly A polymerase C-terminal region-like
signature sequence match: SUPFAM SSF81891 match 1

PS51371
type: Resource
database: PROSITE
comment: CBS
signature sequence match: PROSITE PS51371 match 1
signature sequence match: PROSITE PS51371 match 2

SIPFA15422CA0128D28
type: Structured Name
full name: A-adding tRNA nucleotidyltransferase
short name: A-adding TNT
ec name: 2.7.7.-

SIP8ED6CA6C8EBC834F
type: Structured Name
full name: A-adding enzyme

http://purl.uniprot.org/uniprot/O66728#gene-MD55DAE26397719DF855C350668081ACE9D
type: Gene
locus name: aq_411

SIPA8E751C6C6CEE02B
type: Function Annotation
comment: tRNA nucleotidyltransferase involved in the synthesis of the tRNA CCA terminus. Adds the terminal adenosine residue to tRNA (PubMed:11701927, PubMed:25914059). Can incorporate CMP into tRNA ending with C74C75 (tRNACC), with very weak efficiency (PubMed:25914059).

SIP99CDB5D1005F691F
type: Kinetics Annotation
comment: kcat is 0.10 min(-1) for incorporation of AMP into tRNACC. kcat is 0.00015 min(-1) for incorporation of CMP into tRNACC.
measured affinity: 98 uM for ATP
measured affinity: 220 uM for CTP

SIPCE6E7FA5CBD44362
type: Domain Annotation
comment: Adopts a seahorse-like shape and consists of four domains: head, neck, body, and tail.

SIPE79BFAAD799B980D
type: Similarity Annotation
comment: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

PRO_0000447563
type: Chain Annotation
comment: A-adding tRNA nucleotidyltransferase
mass: 94658
range: 22296129642313774tt1tt824

22296129642313774tt1
type: Position
type: ExactPosition
position: 1
reference: O66728-1

22296129642313774tt824
type: Position
type: ExactPosition
position: 824
reference: O66728-1

SIP0AABFE1A1BF11827
type: Domain Extent Annotation
comment: CBS 1
range: 22296129642313774tt305tt363

22296129642313774tt305
type: Position
type: ExactPosition
position: 305
reference: O66728-1

22296129642313774tt363
type: Position
type: ExactPosition
position: 363
reference: O66728-1

SIPE3DF0377A3213C24
type: Domain Extent Annotation
comment: CBS 2
range: 22296129642313774tt367tt423

22296129642313774tt367
type: Position
type: ExactPosition
position: 367
reference: O66728-1

22296129642313774tt423
type: Position
type: ExactPosition
position: 423
reference: O66728-1

22296129642313774tt459
type: Position
type: ExactPosition
position: 459
reference: O66728-1

22296129642313774tt462
type: Position
type: ExactPosition
position: 462
reference: O66728-1

22296129642313774tt472
type: Position
type: ExactPosition
position: 472
reference: O66728-1

22296129642313774tt474
type: Position
type: ExactPosition
position: 474
reference: O66728-1

22296129642313774tt545
type: Position
type: ExactPosition
position: 545
reference: O66728-1

22296129642313774tt546
type: Position
type: ExactPosition
position: 546
reference: O66728-1

22296129642313774tt550
type: Position
type: ExactPosition
position: 550
reference: O66728-1

22296129642313774tt590
type: Position
type: ExactPosition
position: 590
reference: O66728-1

22296129642313774tt599
type: Position
type: ExactPosition
position: 599
reference: O66728-1

22296129642313774tt603
type: Position
type: ExactPosition
position: 603
reference: O66728-1

22296129642313774tt632
type: Position
type: ExactPosition
position: 632
reference: O66728-1

22296129642313774tt434
type: Position
type: ExactPosition
position: 434
reference: O66728-1

22296129642313774tt449
type: Position
type: ExactPosition
position: 449
reference: O66728-1

22296129642313774tt453
type: Position
type: ExactPosition
position: 453
reference: O66728-1

22296129642313774tt457
type: Position
type: ExactPosition
position: 457
reference: O66728-1

22296129642313774tt465
type: Position
type: ExactPosition
position: 465
reference: O66728-1

22296129642313774tt479
type: Position
type: ExactPosition
position: 479
reference: O66728-1

22296129642313774tt481
type: Position
type: ExactPosition
position: 481
reference: O66728-1

22296129642313774tt492
type: Position
type: ExactPosition
position: 492
reference: O66728-1

22296129642313774tt496
type: Position
type: ExactPosition
position: 496
reference: O66728-1

22296129642313774tt499
type: Position
type: ExactPosition
position: 499
reference: O66728-1

22296129642313774tt500
type: Position
type: ExactPosition
position: 500
reference: O66728-1

22296129642313774tt503
type: Position
type: ExactPosition
position: 503
reference: O66728-1

22296129642313774tt504
type: Position
type: ExactPosition
position: 504
reference: O66728-1

22296129642313774tt509
type: Position
type: ExactPosition
position: 509
reference: O66728-1

22296129642313774tt512
type: Position
type: ExactPosition
position: 512
reference: O66728-1

22296129642313774tt518
type: Position
type: ExactPosition
position: 518
reference: O66728-1

22296129642313774tt538
type: Position
type: ExactPosition
position: 538
reference: O66728-1

22296129642313774tt543
type: Position
type: ExactPosition
position: 543
reference: O66728-1

22296129642313774tt547
type: Position
type: ExactPosition
position: 547
reference: O66728-1

22296129642313774tt548
type: Position
type: ExactPosition
position: 548
reference: O66728-1

22296129642313774tt553
type: Position
type: ExactPosition
position: 553
reference: O66728-1

22296129642313774tt555
type: Position
type: ExactPosition
position: 555
reference: O66728-1

22296129642313774tt558
type: Position
type: ExactPosition
position: 558
reference: O66728-1

22296129642313774tt560
type: Position
type: ExactPosition
position: 560
reference: O66728-1

22296129642313774tt563
type: Position
type: ExactPosition
position: 563
reference: O66728-1

22296129642313774tt565
type: Position
type: ExactPosition
position: 565
reference: O66728-1

22296129642313774tt567
type: Position
type: ExactPosition
position: 567
reference: O66728-1

22296129642313774tt569
type: Position
type: ExactPosition
position: 569
reference: O66728-1

22296129642313774tt570
type: Position
type: ExactPosition
position: 570
reference: O66728-1

22296129642313774tt576
type: Position
type: ExactPosition
position: 576
reference: O66728-1

22296129642313774tt581
type: Position
type: ExactPosition
position: 581
reference: O66728-1

22296129642313774tt583
type: Position
type: ExactPosition
position: 583
reference: O66728-1

22296129642313774tt586
type: Position
type: ExactPosition
position: 586
reference: O66728-1

22296129642313774tt589
type: Position
type: ExactPosition
position: 589
reference: O66728-1

22296129642313774tt592
type: Position
type: ExactPosition
position: 592
reference: O66728-1

22296129642313774tt604
type: Position
type: ExactPosition
position: 604
reference: O66728-1

22296129642313774tt610
type: Position
type: ExactPosition
position: 610
reference: O66728-1

22296129642313774tt621
type: Position
type: ExactPosition
position: 621
reference: O66728-1

22296129642313774tt622
type: Position
type: ExactPosition
position: 622
reference: O66728-1

22296129642313774tt627
type: Position
type: ExactPosition
position: 627
reference: O66728-1

22296129642313774tt630
type: Position
type: ExactPosition
position: 630
reference: O66728-1

22296129642313774tt641
type: Position
type: ExactPosition
position: 641
reference: O66728-1

22296129642313774tt643
type: Position
type: ExactPosition
position: 643
reference: O66728-1

22296129642313774tt645
type: Position
type: ExactPosition
position: 645
reference: O66728-1

22296129642313774tt646
type: Position
type: ExactPosition
position: 646
reference: O66728-1

22296129642313774tt655
type: Position
type: ExactPosition
position: 655
reference: O66728-1

22296129642313774tt659
type: Position
type: ExactPosition
position: 659
reference: O66728-1

22296129642313774tt661
type: Position
type: ExactPosition
position: 661
reference: O66728-1

22296129642313774tt663
type: Position
type: ExactPosition
position: 663
reference: O66728-1

22296129642313774tt665
type: Position
type: ExactPosition
position: 665
reference: O66728-1

22296129642313774tt670
type: Position
type: ExactPosition
position: 670
reference: O66728-1

22296129642313774tt689
type: Position
type: ExactPosition
position: 689
reference: O66728-1

22296129642313774tt691
type: Position
type: ExactPosition
position: 691
reference: O66728-1

22296129642313774tt693
type: Position
type: ExactPosition
position: 693
reference: O66728-1

22296129642313774tt698
type: Position
type: ExactPosition
position: 698
reference: O66728-1

22296129642313774tt705
type: Position
type: ExactPosition
position: 705
reference: O66728-1

22296129642313774tt706
type: Position
type: ExactPosition
position: 706
reference: O66728-1

22296129642313774tt708
type: Position
type: ExactPosition
position: 708
reference: O66728-1

22296129642313774tt711
type: Position
type: ExactPosition
position: 711
reference: O66728-1

22296129642313774tt720
type: Position
type: ExactPosition
position: 720
reference: O66728-1

22296129642313774tt725
type: Position
type: ExactPosition
position: 725
reference: O66728-1

22296129642313774tt736
type: Position
type: ExactPosition
position: 736
reference: O66728-1

22296129642313774tt738
type: Position
type: ExactPosition
position: 738
reference: O66728-1

22296129642313774tt747
type: Position
type: ExactPosition
position: 747
reference: O66728-1

22296129642313774tt751
type: Position
type: ExactPosition
position: 751
reference: O66728-1

22296129642313774tt758
type: Position
type: ExactPosition
position: 758
reference: O66728-1

22296129642313774tt759
type: Position
type: ExactPosition
position: 759
reference: O66728-1

22296129642313774tt761
type: Position
type: ExactPosition
position: 761
reference: O66728-1

22296129642313774tt763
type: Position
type: ExactPosition
position: 763
reference: O66728-1

22296129642313774tt769
type: Position
type: ExactPosition
position: 769
reference: O66728-1

22296129642313774tt773
type: Position
type: ExactPosition
position: 773
reference: O66728-1

22296129642313774tt775
type: Position
type: ExactPosition
position: 775
reference: O66728-1

22296129642313774tt776
type: Position
type: ExactPosition
position: 776
reference: O66728-1

22296129642313774tt784
type: Position
type: ExactPosition
position: 784
reference: O66728-1

22296129642313774tt786
type: Position
type: ExactPosition
position: 786
reference: O66728-1

22296129642313774tt788
type: Position
type: ExactPosition
position: 788
reference: O66728-1

22296129642313774tt793
type: Position
type: ExactPosition
position: 793
reference: O66728-1

22296129642313774tt800
type: Position
type: ExactPosition
position: 800
reference: O66728-1

22296129642313774tt807
type: Position
type: ExactPosition
position: 807
reference: O66728-1

22296129642313774tt821
type: Position
type: ExactPosition
position: 821
reference: O66728-1

O66728-1
type: Simple Sequence
modified: 1998-08-01
version: 1
mass: 94658
value: MVCPKVVILSEGADLDSLSAAYGVLKLYPDAYLLKPKHLSKKAGEVFKKYRDKFRVIEDLPDCFELVLVDTHFLPEGLPRERIKRIIVYDHHPIGDVKEFEGKIEKVGAATTLVVEEIKEKGIDINPRDATLLAFGIYEDTGNFTYEGTTPRDALALAFLLEKGANLREIREVVMETYTPEQIEAVGKIVQSIEKVFINGRQISFATAVLERYQPDINTLLYEIKDLKESDAFFVIIEAEGKTYVFGRSQSEDVDVGEILSHFGGGGHREAGAVKLENVSAERIKELIKAFLKRKYVKLKVRDIMNTPPFVLEEHVSVKDALTELSERGIANAPVINREGKLVGIISKKALLKLVKLYPDEPIELFVNRDFYTLSPDAPVWEAEEILTKFGQKLIPVVEDGTVVGVVTRLDILQAVKEDLEKLKEKRRKIKVPENIEEIAREVGQIAKEMGLRAYIVGGVVRDILLGKEVWDVDFVVEGNAIELAKELARRHGVNVHPFPEFGTAHLKIGKLKLEFATARRETYPRPGAYPKVEPASLKEDLIRRDFTINAMAISVNLEDYGTLIDYFGGLRDLKDKVIRVLHPVSFIEDPVRILRALRFAGRLNFKLSRSTEKLLKQAVNLGLLKEAPRGRLINEIKLALREDRFLEILELYRKYRVLEEIIEGFQWNEKVLQKLYALRKVVDWHALEFSEERIDYGWLYLLILISNLDYERGKHFLEEMSAPSWVRETYKFMKFKLGSLKEELKKAKENYEVYRLLKPLHTSVLLLLMLEEELKEKIKLYLEKLRKVKLPKEKIEELKKQGLKGKELGERIEELKREIMNKI

http://purl.uniprot.org/uniprot/O66728#attribution-5A50C6BB6D3FC48F0175E9798F6A7A65
manual: true
evidence: ECO_0000255
source: PRU00703

http://purl.uniprot.org/uniprot/O66728#attribution-5FA6BA50FDFDD52555F53F792CCE8CD9
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/11701927

http://purl.uniprot.org/uniprot/O66728#attribution-054684D3EB99BB81E62CF1ED3F282567
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/25914059

http://purl.uniprot.org/uniprot/O66728#attribution-47630E0720C52106A079258548B49163
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/11701927

http://purl.uniprot.org/uniprot/O66728#attribution-B2713C35EA49EA8F826F63AE47B98EC3
manual: true
evidence: ECO_0000305

http://purl.uniprot.org/uniprot/O66728#attribution-30FA41D4DFAB4F568E41E56102A086BB
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/15295603

http://purl.uniprot.org/uniprot/O66728#attribution-5F27C957EC946F81D20A221D8260DC87
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/25914059

http://purl.uniprot.org/uniprot/O66728#attribution-DBD79CA09A4D25DCEB7FE1CF96F1C37B
manual: true
evidence: ECO_0000312
source: AAC06692.1

http://purl.uniprot.org/uniprot/O66728#attribution-2392D4D39F8C530358523B988A011BBE
manual: true
evidence: ECO_0007744
source: 1VFG

http://purl.uniprot.org/uniprot/O66728#attribution-BDCCC6DDAA72B62B335B7E0FB2145BA3
manual: true
evidence: ECO_0007744
source: 4WBY

http://purl.uniprot.org/uniprot/O66728#attribution-C62E740C6D329CA957C58FF6ADECE43A
manual: true
evidence: ECO_0007744
source: 4WBZ

http://purl.uniprot.org/uniprot/O66728#attribution-95D0E5573229678292EAED679F0E38CE
manual: true
evidence: ECO_0007744
source: 4WC0

http://purl.uniprot.org/uniprot/O66728#attribution-179AAC055EDFE105B6E8E6F984118848
manual: true
evidence: ECO_0007744
source: 4WC1

http://purl.uniprot.org/uniprot/O66728#attribution-70F3EFD35337507068B58741CC705816
manual: true
evidence: ECO_0007744
source: 4WC2

http://purl.uniprot.org/uniprot/O66728#attribution-23213364057122D5DD94C6A7406E4E4C
manual: true
evidence: ECO_0007744
source: 4WC3

http://purl.uniprot.org/uniprot/O66728#attribution-2E2C52F2036BC26CDD8AF71A7F8D9460
manual: true
evidence: ECO_0007744
source: 4WC4

http://purl.uniprot.org/uniprot/O66728#attribution-9AEFB9DDDDB46BCAD2E63FD9476BB3F9
manual: true
evidence: ECO_0007744
source: 4WC5

http://purl.uniprot.org/uniprot/O66728#attribution-433A97B32153B006D2657CB933CDAF26
manual: true
evidence: ECO_0007744
source: 4WC6

http://purl.uniprot.org/uniprot/O66728#attribution-5A374225982DEBB275EEEF1425C2285A
manual: true
evidence: ECO_0007744
source: 4WC7

http://purl.uniprot.org/uniprot/O66728#attribution-CC8CF4A13719968AE8DF968838F5BF38
manual: true
evidence: ECO_0007744
source: 4X0A

O67260
type: Protein
reviewed: true
created: 1999-07-15
modified: 2023-09-13
version: 127
mnemonic: ACCA_AQUAE
citation: http://purl.uniprot.org/citations/9537320
recommended name: SIPD345ED6FED4C7897
enzyme: http://purl.uniprot.org/enzyme/2.1.3.15
organism: http://purl.uniprot.org/taxonomy/224324
annotation: SIP64032EFC57F6FF3D
annotation: SIPEA59E68058D0EEBA
annotation: SIPDA391BC0F5A0BC3E
annotation: SIP902CB22C51FCE3B5
annotation: SIPAD263BBBD803DAC9
annotation: SIPB0C4E7DABDADE11E
annotation: PRO_0000146772
annotation: SIP74A3670F862AB59C
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/275
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/808
classified with: GO_0009317
classified with: GO_0003989
classified with: GO_0005524
classified with: GO_0016743
classified with: GO_0006633
classified with: GO_2001295
sequence: O67260-1
proteome: Chromosome

O67260-citation-9537320
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

VF5
type: Strain

COG0825
type: Resource
database: eggNOG
comment: Bacteria

MF_00823
type: Resource
database: HAMAP
comment: AcetylCoA_CT_alpha
signature sequence match: HAMAP MF 00823 match 1

IPR001095
type: Resource
database: InterPro
comment: Acetyl_CoA_COase_a_su

IPR029045
type: Resource
database: InterPro
comment: ClpP/crotonase-like_dom_sf

IPR011763
type: Resource
database: InterPro
comment: COA_CT_C

TIGR00513
type: Resource
database: NCBIfam
comment: accA
signature sequence match: NCBIfam TIGR00513 match 1

PTHR42853
type: Resource
database: PANTHER
comment: ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE SUBUNIT ALPHA
signature sequence match: PANTHER PTHR42853 match 1

PTHR42853:SF3
type: Resource
database: PANTHER
comment: ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE SUBUNIT ALPHA, CHLOROPLASTIC
signature sequence match: PANTHER PTHR42853:SF3 match 1

PF03255
type: Resource
database: Pfam
comment: ACCA
signature sequence match: Pfam PF03255 match 1

PR01069
type: Resource
database: PRINTS
comment: ACCCTRFRASEA

SSF52096
type: Resource
database: SUPFAM
comment: ClpP/crotonase
signature sequence match: SUPFAM SSF52096 match 1

PS50989
type: Resource
database: PROSITE
comment: COA_CT_CTER
signature sequence match: PROSITE PS50989 match 1

SIPD345ED6FED4C7897
type: Structured Name
full name: Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
short name: ACCase subunit alpha
short name: Acetyl-CoA carboxylase carboxyltransferase subunit alpha
ec name: 2.1.3.15

accA
type: Gene
locus name: aq_1206

SIP64032EFC57F6FF3D
type: Function Annotation
comment: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.

SIP902CB22C51FCE3B5
type: Subunit Annotation
comment: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).

SIPB0C4E7DABDADE11E
type: Similarity Annotation
comment: Belongs to the AccA family.

PRO_0000146772
type: Chain Annotation
comment: Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
mass: 36198
range: 22296133853655086tt1tt323

22296133853655086tt1
type: Position
type: ExactPosition
position: 1
reference: O67260-1

22296133853655086tt323
type: Position
type: ExactPosition
position: 323
reference: O67260-1

SIP74A3670F862AB59C
type: Domain Extent Annotation
comment: CoA carboxyltransferase C-terminal
range: 22296133853655086tt35tt296

22296133853655086tt35
type: Position
type: ExactPosition
position: 35
reference: O67260-1

22296133853655086tt296
type: Position
type: ExactPosition
position: 296
reference: O67260-1

O67260-1
type: Simple Sequence
modified: 1998-08-01
version: 1
mass: 36198
value: MILFKVMHLEFEKELLEIKEKIDRLLGLYRLGKEEVLSELDELRKKFKEKARKIYRDLSPWERVQVARHPKRPHTSDYIKYLIKDFEEVHGDTCYGDDKAVIAGFGYFRGKPVAVVGHEKGKDTKEKLERNFGMPHPEGYRKAIKVFKLAERYNIPVITFIDTPGAFPGIGAEERGQSRAIAESMLTMAFLKVPSVAVVIGEGGSGGALAFGVANRVCILENAYYSVISPEGCAAILWKDQSKVKEAAKALRLTAKDLKELGVVDCVIPEPYGAAHWSPRGTAMMVGMTLKKCLDELSKLTEEGVVRSRLEKFKNMGAFKIAS

http://purl.uniprot.org/uniprot/O67260#attribution-59F6F4DF8DA7A0D31AA2B64E6869E9D5
manual: true
evidence: ECO_0000255
source: MF_00823

http://purl.uniprot.org/uniprot/O67260#attribution-71DD31C3EAE9838607F06234F6539BBA
manual: true
evidence: ECO_0000255
source: PRU01137

B4U8Q5
type: Protein
reviewed: true
created: 2009-12-15
modified: 2023-09-13
version: 76
mnemonic: ACCD_HYDS0
citation: http://purl.uniprot.org/citations/19136599
recommended name: SIP00CD3CD25DEDD34F
enzyme: http://purl.uniprot.org/enzyme/2.1.3.15
organism: http://purl.uniprot.org/taxonomy/380749
annotation: SIP5D10C815186A8C79
annotation: SIPAF1983EA42D1B11A
annotation: SIP51DE48A6E017BF8A
annotation: SIP501FA823AF866A48
annotation: SIPE663A319C88572C8
annotation: SIP8BE44E1F6F336634
annotation: SIP451A05B696CB0325
annotation: PRO_0000389757
annotation: SIPA0889DC330DEABDA
annotation: SIP4E3EC50C21FC7390
annotation: SIP01CB1AFC035F5C9F
annotation: SIP1BD6DF3E6A0A14B5
annotation: SIP4C18442AFBB5F772
annotation: SIP69E664BEC383A21B
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/275
classified with: http://purl.uniprot.org/keywords/808
classified with: http://purl.uniprot.org/keywords/863
classified with: GO_0009317
classified with: GO_0003989
classified with: GO_0005524
classified with: GO_0016743
classified with: GO_0008270
classified with: GO_0006633
classified with: GO_2001295
sequence: B4U8Q5-1

B4U8Q5-citation-19136599
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

Y04AAS1
type: Strain

COG0777
type: Resource
database: eggNOG
comment: Bacteria

MF_01395
type: Resource
database: HAMAP
comment: AcetylCoA_CT_beta
signature sequence match: HAMAP MF 01395 match 1

IPR034733
type: Resource
database: InterPro
comment: AcCoA_carboxyl

IPR000438
type: Resource
database: InterPro
comment: Acetyl_CoA_COase_Trfase_b_su

IPR011762
type: Resource
database: InterPro
comment: COA_CT_N

IPR041010
type: Resource
database: InterPro
comment: Znf-ACC

TIGR00515
type: Resource
database: NCBIfam
comment: accD
signature sequence match: NCBIfam TIGR00515 match 1

PTHR42995
type: Resource
database: PANTHER
comment: ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE SUBUNIT BETA, CHLOROPLASTIC
signature sequence match: PANTHER PTHR42995 match 1

PTHR42995:SF5
type: Resource
database: PANTHER
comment: ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE SUBUNIT BETA, CHLOROPLASTIC
signature sequence match: PANTHER PTHR42995:SF5 match 1

PF01039
type: Resource
database: Pfam
comment: Carboxyl_trans
signature sequence match: Pfam PF01039 match 1

PF17848
type: Resource
database: Pfam
comment: zf-ACC
signature sequence match: Pfam PF17848 match 1

PR01070
type: Resource
database: PRINTS
comment: ACCCTRFRASEB

PS50980
type: Resource
database: PROSITE
comment: COA_CT_NTER
signature sequence match: PROSITE PS50980 match 1

SIP00CD3CD25DEDD34F
type: Structured Name
full name: Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
short name: ACCase subunit beta
short name: Acetyl-CoA carboxylase carboxyltransferase subunit beta
ec name: 2.1.3.15

accD
type: Gene
locus name: HY04AAS1_0829

SIP5D10C815186A8C79
type: Function Annotation
comment: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.

SIP51DE48A6E017BF8A
type: Cofactor Annotation
comment: Binds 1 zinc ion per subunit.
cofactor: CHEBI_29105

SIPE663A319C88572C8
type: Subunit Annotation
comment: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).

SIP451A05B696CB0325
type: Similarity Annotation
comment: Belongs to the AccD/PCCB family.

PRO_0000389757
type: Chain Annotation
comment: Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
mass: 30999
range: 18634889084613934tt1tt274

18634889084613934tt1
type: Position
type: ExactPosition
position: 1
reference: B4U8Q5-1

18634889084613934tt274
type: Position
type: ExactPosition
position: 274
reference: B4U8Q5-1

SIPA0889DC330DEABDA
type: Domain Extent Annotation
comment: CoA carboxyltransferase N-terminal
range: 18634889084613934tt16tt274

18634889084613934tt16
type: Position
type: ExactPosition
position: 16
reference: B4U8Q5-1

SIP4E3EC50C21FC7390
type: Zinc Finger Annotation
comment: C4-type
range: 18634889084613934tt20tt42

18634889084613934tt20
type: Position
type: ExactPosition
position: 20
reference: B4U8Q5-1

18634889084613934tt42
type: Position
type: ExactPosition
position: 42
reference: B4U8Q5-1

18634889084613934tt23
type: Position
type: ExactPosition
position: 23
reference: B4U8Q5-1

18634889084613934tt39
type: Position
type: ExactPosition
position: 39
reference: B4U8Q5-1

B4U8Q5-1
type: Simple Sequence
modified: 2008-09-23
version: 1
mass: 30999
value: MGILDFFRKKEKKENLWTKCEECKNILLAQELETNFYVCPKCGHHHQMNPYLWASMLLDYNYNVLFEYILPTDFLSFKDTKRYKDRLKTLKETSNTSEAMTVFDGKLSDYPVVLSVMDFSFIGGSMGSVVGERFKLASLKAVQDKKPHISVVTSGGARMQESVISLMQMAKTSIAVDIMHKNGIPFITVLTNPTTGGVSASFAFLGDVIIAEPKAIIGFAGARVIEQTIKQQLPEDFQTSEFLLKKGMVDMVVHRHLMKQTLKNLLNLLFYKNA

http://purl.uniprot.org/uniprot/B4U8Q5#attribution-346A549594E8317A7ADA810973E8C603
manual: true
evidence: ECO_0000255
source: MF_01395

http://purl.uniprot.org/uniprot/B4U8Q5#attribution-A7637AD2023CC0EB7C88908B79959652
manual: true
evidence: ECO_0000255
source: PRU01136

B2V5V9
type: Protein
reviewed: true
created: 2009-12-15
modified: 2023-09-13
version: 83
mnemonic: ACCD_SULSY
citation: http://purl.uniprot.org/citations/19136599
recommended name: SIP00CD3CD25DEDD34F
enzyme: http://purl.uniprot.org/enzyme/2.1.3.15
organism: http://purl.uniprot.org/taxonomy/436114
annotation: SIPE49041E2DA034DE9
annotation: SIPD4D28B4878ACA445
annotation: SIPF1BE143816B4B764
annotation: SIPDA0F1BC3C217EAD6
annotation: SIP505DD3FCE1600F86
annotation: SIP80355CDFBFDD86D4
annotation: SIP7E3B445CBB0236AB
annotation: PRO_0000389892
annotation: SIP8D79177BB83111FA
annotation: SIP9B57260A5E19DD34
annotation: SIP5E4E4BB73B760D3C
annotation: SIPCA03A06510A1CA71
annotation: SIP5E8DD1A313097ADC
annotation: SIP8DD5003A7E2D8673
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/275
classified with: http://purl.uniprot.org/keywords/808
classified with: http://purl.uniprot.org/keywords/863
classified with: GO_0009317
classified with: GO_0003989
classified with: GO_0005524
classified with: GO_0016743
classified with: GO_0008270
classified with: GO_0006633
classified with: GO_2001295
sequence: B2V5V9-1

B2V5V9-citation-19136599
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

YO3AOP1
type: Strain

SIP00CD3CD25DEDD34F
type: Structured Name
full name: Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
short name: ACCase subunit beta
short name: Acetyl-CoA carboxylase carboxyltransferase subunit beta
ec name: 2.1.3.15

accD
type: Gene
locus name: SYO3AOP1_1451

SIPE49041E2DA034DE9
type: Function Annotation
comment: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.

SIPF1BE143816B4B764
type: Cofactor Annotation
comment: Binds 1 zinc ion per subunit.
cofactor: CHEBI_29105

SIP505DD3FCE1600F86
type: Subunit Annotation
comment: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).

SIP7E3B445CBB0236AB
type: Similarity Annotation
comment: Belongs to the AccD/PCCB family.

PRO_0000389892
type: Chain Annotation
comment: Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
mass: 31375
range: 18632694306322734tt1tt280

18632694306322734tt1
type: Position
type: ExactPosition
position: 1
reference: B2V5V9-1

18632694306322734tt280
type: Position
type: ExactPosition
position: 280
reference: B2V5V9-1

SIP8D79177BB83111FA
type: Domain Extent Annotation
comment: CoA carboxyltransferase N-terminal
range: 18632694306322734tt24tt280

18632694306322734tt24
type: Position
type: ExactPosition
position: 24
reference: B2V5V9-1

SIP9B57260A5E19DD34
type: Zinc Finger Annotation
comment: C4-type
range: 18632694306322734tt28tt50

18632694306322734tt28
type: Position
type: ExactPosition
position: 28
reference: B2V5V9-1

18632694306322734tt50
type: Position
type: ExactPosition
position: 50
reference: B2V5V9-1

18632694306322734tt31
type: Position
type: ExactPosition
position: 31
reference: B2V5V9-1

18632694306322734tt47
type: Position
type: ExactPosition
position: 47
reference: B2V5V9-1

B2V5V9-1
type: Simple Sequence
modified: 2008-07-01
version: 1
mass: 31375
value: MGLKDFVDKLKNIKKSRIKIEEGAWIKCDKCKNILYIEDLLKNLKICPHCGYTFRMNAKERVDSLLDKVYSYDLFPKIKPVDIIGFKDTKRYKDRLKEAQEKTGLNDAIIIAHGNIYDREVVLASMDFNFMGGSMGSVVGAKFVRGVEFAIEKSIPFISVAASGGARMQESIVSLMQMAKTAIAIDRLNKAGILYISVLTDPTMGGVSASFAFLGDIIIAEPESLIGFAGPRVIEQTIRQQLPEGFQRAEFLLEKGQIDMVVDRKNLKKTIYTLIRHTHG

http://purl.uniprot.org/uniprot/B2V5V9#attribution-346A549594E8317A7ADA810973E8C603
manual: true
evidence: ECO_0000255
source: MF_01395

http://purl.uniprot.org/uniprot/B2V5V9#attribution-A7637AD2023CC0EB7C88908B79959652
manual: true
evidence: ECO_0000255
source: PRU01136

O66995
type: Protein
reviewed: true
created: 2000-05-30
modified: 2023-09-13
version: 124
mnemonic: ACPS_AQUAE
citation: http://purl.uniprot.org/citations/9537320
recommended name: SIP2BEBC682D9C5D011
alternative name: SIP479C3A2215184A35
enzyme: http://purl.uniprot.org/enzyme/2.7.8.7
organism: http://purl.uniprot.org/taxonomy/224324
annotation: SIP80F66757C039444B
annotation: SIP2FE2AF97A248AFFE
annotation: SIP6DB0929FA6D79666
annotation: SIP63702113A74FE327
annotation: SIP682422491DBE9BEA
annotation: PRO_0000175605
annotation: SIP9143835AAAEE02B8
annotation: SIP45A88857713B0FD0
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/275
classified with: http://purl.uniprot.org/keywords/460
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/808
classified with: GO_0005737
classified with: GO_0008897
classified with: GO_0000287
classified with: GO_0006633
sequence: MIGVDIVKNERIKDALERFGDKFLDRIYTKRELEYCYAHCDFLPCLAARWAGKEAVLKAFYTEFKIFLRFKEIEILGNRGRPPTVVINREGVEEILKNYEVIVSLSHERDYSVAVAYIKKKS
proteome: Chromosome

O66995-citation-9537320
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

VF5
type: Strain

COG0736
type: Resource
database: eggNOG
comment: Bacteria

http://purl.uniprot.org/gene3d/3.90.470.20
type: Resource
database: Gene3D
comment: 4'-phosphopantetheinyl transferase domain
signature sequence match: Gene3D 3.90.470.20 match 1

MF_00101
type: Resource
database: HAMAP
comment: AcpS
signature sequence match: HAMAP MF 00101 match 1

IPR008278
type: Resource
database: InterPro
comment: 4-PPantetheinyl_Trfase_dom

IPR037143
type: Resource
database: InterPro
comment: 4-PPantetheinyl_Trfase_dom_sf

IPR002582
type: Resource
database: InterPro
comment: ACPS

IPR004568
type: Resource
database: InterPro
comment: Ppantetheine-prot_Trfase_dom

TIGR00516
type: Resource
database: NCBIfam
comment: acpS
signature sequence match: NCBIfam TIGR00516 match 1

TIGR00556
type: Resource
database: NCBIfam
comment: pantethn_trn
signature sequence match: NCBIfam TIGR00556 match 1

PF01648
type: Resource
database: Pfam
comment: ACPS
signature sequence match: Pfam PF01648 match 1

SSF56214
type: Resource
database: SUPFAM
comment: 4'-phosphopantetheinyl transferase
signature sequence match: SUPFAM SSF56214 match 1

SIP2BEBC682D9C5D011
type: Structured Name
full name: Holo-[acyl-carrier-protein] synthase
short name: Holo-ACP synthase
ec name: 2.7.8.7

SIP479C3A2215184A35
type: Structured Name
full name: 4'-phosphopantetheinyl transferase AcpS

acpS
type: Gene
locus name: aq_813

SIP80F66757C039444B
type: Function Annotation
comment: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

SIP682422491DBE9BEA
type: Similarity Annotation
comment: Belongs to the P-Pant transferase superfamily. AcpS family.

PRO_0000175605
type: Chain Annotation
comment: Holo-[acyl-carrier-protein] synthase
mass: 14310
range: 22296129676326190tt1tt122

22296129676326190tt1
type: Position
type: ExactPosition
position: 1
reference: MIGVDIVKNERIKDALERFGDKFLDRIYTKRELEYCYAHCDFLPCLAARWAGKEAVLKAFYTEFKIFLRFKEIEILGNRGRPPTVVINREGVEEILKNYEVIVSLSHERDYSVAVAYIKKKS

22296129676326190tt122
type: Position
type: ExactPosition
position: 122
reference: MIGVDIVKNERIKDALERFGDKFLDRIYTKRELEYCYAHCDFLPCLAARWAGKEAVLKAFYTEFKIFLRFKEIEILGNRGRPPTVVINREGVEEILKNYEVIVSLSHERDYSVAVAYIKKKS

22296129676326190tt5
type: Position
type: ExactPosition
position: 5
reference: MIGVDIVKNERIKDALERFGDKFLDRIYTKRELEYCYAHCDFLPCLAARWAGKEAVLKAFYTEFKIFLRFKEIEILGNRGRPPTVVINREGVEEILKNYEVIVSLSHERDYSVAVAYIKKKS

22296129676326190tt54
type: Position
type: ExactPosition
position: 54
reference: MIGVDIVKNERIKDALERFGDKFLDRIYTKRELEYCYAHCDFLPCLAARWAGKEAVLKAFYTEFKIFLRFKEIEILGNRGRPPTVVINREGVEEILKNYEVIVSLSHERDYSVAVAYIKKKS

MIGVDIVKNERIKDALERFGDKFLDRIYTKRELEYCYAHCDFLPCLAARWAGKEAVLKAFYTEFKIFLRFKEIEILGNRGRPPTVVINREGVEEILKNYEVIVSLSHERDYSVAVAYIKKKS
type: Simple Sequence
modified: 1998-08-01
version: 1
mass: 14310

http://purl.uniprot.org/uniprot/O66995#attribution-1F5F5386E209DFCC3422387253639116
manual: true
evidence: ECO_0000255
source: MF_00101

B4U7U7
type: Protein
reviewed: true
created: 2009-03-24
modified: 2023-09-13
version: 82
mnemonic: ACPS_HYDS0
citation: http://purl.uniprot.org/citations/19136599
recommended name: SIP2BEBC682D9C5D011
alternative name: SIP479C3A2215184A35
enzyme: http://purl.uniprot.org/enzyme/2.7.8.7
organism: http://purl.uniprot.org/taxonomy/380749
annotation: SIP8792F3E4D77ACA84
annotation: SIP881DCAA7C32208F9
annotation: SIP881CFBFEFABF0918
annotation: SIPA12CEE1F5DB5D2BE
annotation: SIPE93B8C9CB4147810
annotation: PRO_1000093883
annotation: SIPED3739EB9BE5615E
annotation: SIPC62C3D24D4CFAB66
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/275
classified with: http://purl.uniprot.org/keywords/460
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/808
classified with: GO_0005737
classified with: GO_0008897
classified with: GO_0000287
classified with: GO_0006633
sequence: MLGIDIIKNIRIAKALERFGYHFLNRVYTEYEINLCKMNVECLSGRFAAKEASIKAFSFLSIRRFSFRDFEVVKSKNGIPELRIKDAYINDFLKAQKLKPFISISHEKEFSVAVCYITKEERIC

B4U7U7-citation-19136599
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

Y04AAS1
type: Strain

SIP2BEBC682D9C5D011
type: Structured Name
full name: Holo-[acyl-carrier-protein] synthase
short name: Holo-ACP synthase
ec name: 2.7.8.7

SIP479C3A2215184A35
type: Structured Name
full name: 4'-phosphopantetheinyl transferase AcpS

acpS
type: Gene
locus name: HY04AAS1_0521

SIP8792F3E4D77ACA84
type: Function Annotation
comment: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

SIPE93B8C9CB4147810
type: Similarity Annotation
comment: Belongs to the P-Pant transferase superfamily. AcpS family.

PRO_1000093883
type: Chain Annotation
comment: Holo-[acyl-carrier-protein] synthase
mass: 14526
range: 18634889068099374tt1tt124

18634889068099374tt1
type: Position
type: ExactPosition
position: 1
reference: MLGIDIIKNIRIAKALERFGYHFLNRVYTEYEINLCKMNVECLSGRFAAKEASIKAFSFLSIRRFSFRDFEVVKSKNGIPELRIKDAYINDFLKAQKLKPFISISHEKEFSVAVCYITKEERIC

18634889068099374tt124
type: Position
type: ExactPosition
position: 124
reference: MLGIDIIKNIRIAKALERFGYHFLNRVYTEYEINLCKMNVECLSGRFAAKEASIKAFSFLSIRRFSFRDFEVVKSKNGIPELRIKDAYINDFLKAQKLKPFISISHEKEFSVAVCYITKEERIC

18634889068099374tt5
type: Position
type: ExactPosition
position: 5
reference: MLGIDIIKNIRIAKALERFGYHFLNRVYTEYEINLCKMNVECLSGRFAAKEASIKAFSFLSIRRFSFRDFEVVKSKNGIPELRIKDAYINDFLKAQKLKPFISISHEKEFSVAVCYITKEERIC

18634889068099374tt51
type: Position
type: ExactPosition
position: 51
reference: MLGIDIIKNIRIAKALERFGYHFLNRVYTEYEINLCKMNVECLSGRFAAKEASIKAFSFLSIRRFSFRDFEVVKSKNGIPELRIKDAYINDFLKAQKLKPFISISHEKEFSVAVCYITKEERIC

MLGIDIIKNIRIAKALERFGYHFLNRVYTEYEINLCKMNVECLSGRFAAKEASIKAFSFLSIRRFSFRDFEVVKSKNGIPELRIKDAYINDFLKAQKLKPFISISHEKEFSVAVCYITKEERIC
type: Simple Sequence
modified: 2008-09-23
version: 1
mass: 14526

http://purl.uniprot.org/uniprot/B4U7U7#attribution-1F5F5386E209DFCC3422387253639116
manual: true
evidence: ECO_0000255
source: MF_00101

O67611
type: Protein
reviewed: true
created: 1998-12-15
modified: 2023-09-13
version: 130
mnemonic: ACP_AQUAE
citation: http://purl.uniprot.org/citations/9537320
recommended name: SIPF018D8BE7E205B4F
organism: http://purl.uniprot.org/taxonomy/224324
annotation: SIP3B13053BB0066306
annotation: SIP19EFF29C9D8EE633
annotation: SIPEF9C6F583AFF6C2C
annotation: SIP5D094A7D1769B660
annotation: SIP2141642366C3EE66
annotation: PRO_0000180094
annotation: SIPB94AD4F3D1DDC8D6
annotation: SIP38EEE3DE7E40CA95
annotation: SIP646758ED1AF1E5FF
annotation: SIPC27C62365409A1B9
annotation: SIP70FDC0A3FA04AEB9
annotation: SIP0A64014C5FEE51FB
annotation: SIP5CC8F58067590048
annotation: SIP9D4985BA6AD13FCB
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/275
classified with: http://purl.uniprot.org/keywords/596
classified with: http://purl.uniprot.org/keywords/597
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005829
classified with: GO_0000035
classified with: GO_0000036
classified with: GO_0031177
classified with: GO_0009245
sequence: MSLEERVKEIIAEQLGVEKEKITPEAKFVEDLGADSLDVVELIMAFEEEFGIEIPDEDAEKIQTVGDVINYLKEKVGG
proteome: Chromosome

O67611-citation-9537320
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

VF5
type: Strain

2EHS
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 1.30
chain sequence mapping: PDB 2EHS tt2tt78

PDB 2EHS tt2tt78
chain: A=2-78

2EHT
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 1.40
chain sequence mapping: PDB 2EHT tt2tt78

PDB 2EHT tt2tt78
chain: A=2-78

COG0236
type: Resource
database: eggNOG
comment: Bacteria

http://purl.uniprot.org/gene3d/1.10.1200.10
type: Resource
database: Gene3D
comment: ACP-like
signature sequence match: Gene3D 1.10.1200.10 match 1

MF_01217
type: Resource
database: HAMAP
comment: Acyl_carrier
signature sequence match: HAMAP MF 01217 match 1

IPR036736
type: Resource
database: InterPro
comment: ACP-like_sf

IPR003231
type: Resource
database: InterPro
comment: Acyl_carrier

IPR020806
type: Resource
database: InterPro
comment: PKS_PP-bd

IPR009081
type: Resource
database: InterPro
comment: PP-bd_ACP

IPR006162
type: Resource
database: InterPro
comment: Ppantetheine_attach_site

TIGR00517
type: Resource
database: NCBIfam
comment: acyl_carrier
signature sequence match: NCBIfam TIGR00517 match 1

PTHR20863
type: Resource
database: PANTHER
comment: ACYL CARRIER PROTEIN
signature sequence match: PANTHER PTHR20863 match 1

PTHR20863:SF28
type: Resource
database: PANTHER
comment: ACYL CARRIER PROTEIN, MITOCHONDRIAL
signature sequence match: PANTHER PTHR20863:SF28 match 1

PF00550
type: Resource
database: Pfam
comment: PP-binding
signature sequence match: Pfam PF00550 match 1

SM00823
type: Resource
database: SMART
comment: PKS_PP
signature sequence match: SMART SM00823 match 1

SSF47336
type: Resource
database: SUPFAM
comment: ACP-like
signature sequence match: SUPFAM SSF47336 match 1

PS50075
type: Resource
database: PROSITE
comment: CARRIER
signature sequence match: PROSITE PS50075 match 1

PS00012
type: Resource
database: PROSITE
comment: PHOSPHOPANTETHEINE
signature sequence match: PROSITE PS00012 match 1

SIPF018D8BE7E205B4F
type: Structured Name
full name: Acyl carrier protein
short name: ACP

acpP
type: Gene
locus name: aq_1716.1
orf name: aq_1717A

SIP3B13053BB0066306
type: Function Annotation
comment: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

SIP5D094A7D1769B660
type: PTM Annotation
comment: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.

SIP2141642366C3EE66
type: Similarity Annotation
comment: Belongs to the acyl carrier protein (ACP) family.

PRO_0000180094
type: Chain Annotation
comment: Acyl carrier protein
mass: 8711
range: 22296133920436526tt1tt78

22296133920436526tt1
type: Position
type: ExactPosition
position: 1
reference: MSLEERVKEIIAEQLGVEKEKITPEAKFVEDLGADSLDVVELIMAFEEEFGIEIPDEDAEKIQTVGDVINYLKEKVGG

22296133920436526tt78
type: Position
type: ExactPosition
position: 78
reference: MSLEERVKEIIAEQLGVEKEKITPEAKFVEDLGADSLDVVELIMAFEEEFGIEIPDEDAEKIQTVGDVINYLKEKVGG

SIPB94AD4F3D1DDC8D6
type: Domain Extent Annotation
comment: Carrier
range: 22296133920436526tt1tt76

22296133920436526tt76
type: Position
type: ExactPosition
position: 76
reference: MSLEERVKEIIAEQLGVEKEKITPEAKFVEDLGADSLDVVELIMAFEEEFGIEIPDEDAEKIQTVGDVINYLKEKVGG

SIP38EEE3DE7E40CA95
type: Modified Residue Annotation
comment: O-(pantetheine 4'-phosphoryl)serine
range: 22296133920436526tt36tt36

22296133920436526tt36
type: Position
type: ExactPosition
position: 36
reference: MSLEERVKEIIAEQLGVEKEKITPEAKFVEDLGADSLDVVELIMAFEEEFGIEIPDEDAEKIQTVGDVINYLKEKVGG

22296133920436526tt3
type: Position
type: ExactPosition
position: 3
reference: MSLEERVKEIIAEQLGVEKEKITPEAKFVEDLGADSLDVVELIMAFEEEFGIEIPDEDAEKIQTVGDVINYLKEKVGG

22296133920436526tt15
type: Position
type: ExactPosition
position: 15
reference: MSLEERVKEIIAEQLGVEKEKITPEAKFVEDLGADSLDVVELIMAFEEEFGIEIPDEDAEKIQTVGDVINYLKEKVGG

22296133920436526tt19
type: Position
type: ExactPosition
position: 19
reference: MSLEERVKEIIAEQLGVEKEKITPEAKFVEDLGADSLDVVELIMAFEEEFGIEIPDEDAEKIQTVGDVINYLKEKVGG

22296133920436526tt21
type: Position
type: ExactPosition
position: 21
reference: MSLEERVKEIIAEQLGVEKEKITPEAKFVEDLGADSLDVVELIMAFEEEFGIEIPDEDAEKIQTVGDVINYLKEKVGG

22296133920436526tt28
type: Position
type: ExactPosition
position: 28
reference: MSLEERVKEIIAEQLGVEKEKITPEAKFVEDLGADSLDVVELIMAFEEEFGIEIPDEDAEKIQTVGDVINYLKEKVGG

22296133920436526tt32
type: Position
type: ExactPosition
position: 32
reference: MSLEERVKEIIAEQLGVEKEKITPEAKFVEDLGADSLDVVELIMAFEEEFGIEIPDEDAEKIQTVGDVINYLKEKVGG

22296133920436526tt50
type: Position
type: ExactPosition
position: 50
reference: MSLEERVKEIIAEQLGVEKEKITPEAKFVEDLGADSLDVVELIMAFEEEFGIEIPDEDAEKIQTVGDVINYLKEKVGG

22296133920436526tt56
type: Position
type: ExactPosition
position: 56
reference: MSLEERVKEIIAEQLGVEKEKITPEAKFVEDLGADSLDVVELIMAFEEEFGIEIPDEDAEKIQTVGDVINYLKEKVGG

22296133920436526tt60
type: Position
type: ExactPosition
position: 60
reference: MSLEERVKEIIAEQLGVEKEKITPEAKFVEDLGADSLDVVELIMAFEEEFGIEIPDEDAEKIQTVGDVINYLKEKVGG

22296133920436526tt65
type: Position
type: ExactPosition
position: 65
reference: MSLEERVKEIIAEQLGVEKEKITPEAKFVEDLGADSLDVVELIMAFEEEFGIEIPDEDAEKIQTVGDVINYLKEKVGG

22296133920436526tt75
type: Position
type: ExactPosition
position: 75
reference: MSLEERVKEIIAEQLGVEKEKITPEAKFVEDLGADSLDVVELIMAFEEEFGIEIPDEDAEKIQTVGDVINYLKEKVGG

MSLEERVKEIIAEQLGVEKEKITPEAKFVEDLGADSLDVVELIMAFEEEFGIEIPDEDAEKIQTVGDVINYLKEKVGG
type: Simple Sequence
modified: 1998-08-01
version: 1
mass: 8711

http://purl.uniprot.org/uniprot/O67611#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/O67611#attribution-EBFCF1D44A6B78477DFBD33475E43FB0
manual: true
evidence: ECO_0000255
source: MF_01217

http://purl.uniprot.org/uniprot/O67611#attribution-D13C97E04C041CF3567C01508AE538D1
manual: true
evidence: ECO_0000255
source: PRU00258

B4U7T6
type: Protein
reviewed: true
created: 2009-04-14
modified: 2023-09-13
version: 79
mnemonic: ACP_HYDS0
citation: http://purl.uniprot.org/citations/19136599
recommended name: SIPF018D8BE7E205B4F
organism: http://purl.uniprot.org/taxonomy/380749
annotation: SIPFFA6938D23979491
annotation: SIP7E848DF19C15BF2D
annotation: SIPEC9A3BE3D4DC3634
annotation: SIPA5851442D06C4762
annotation: SIPE48D11B38EFB18EF
annotation: PRO_1000139035
annotation: SIP4BA4C83FAD1959CB
annotation: SIPBD06D37BC6270FC2
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/275
classified with: http://purl.uniprot.org/keywords/596
classified with: http://purl.uniprot.org/keywords/597
classified with: GO_0005737
classified with: GO_0000036
sequence: MDREQRIKEIIADQLGVEVDKLTPDAKFVEDLGADSLDVVELIMSFEEEFNIEIPDEDAEKIKTVGDVINYLNEKLK

B4U7T6-citation-19136599
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

Y04AAS1
type: Strain

SIPF018D8BE7E205B4F
type: Structured Name
full name: Acyl carrier protein
short name: ACP

acpP
type: Gene
locus name: HY04AAS1_0510

SIPFFA6938D23979491
type: Function Annotation
comment: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

SIPA5851442D06C4762
type: PTM Annotation
comment: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.

SIPE48D11B38EFB18EF
type: Similarity Annotation
comment: Belongs to the acyl carrier protein (ACP) family.

PRO_1000139035
type: Chain Annotation
comment: Acyl carrier protein
mass: 8811
range: 18634889068033582tt1tt77

18634889068033582tt1
type: Position
type: ExactPosition
position: 1
reference: MDREQRIKEIIADQLGVEVDKLTPDAKFVEDLGADSLDVVELIMSFEEEFNIEIPDEDAEKIKTVGDVINYLNEKLK

18634889068033582tt77
type: Position
type: ExactPosition
position: 77
reference: MDREQRIKEIIADQLGVEVDKLTPDAKFVEDLGADSLDVVELIMSFEEEFNIEIPDEDAEKIKTVGDVINYLNEKLK

SIP4BA4C83FAD1959CB
type: Domain Extent Annotation
comment: Carrier
range: 18634889068033582tt1tt76

18634889068033582tt76
type: Position
type: ExactPosition
position: 76
reference: MDREQRIKEIIADQLGVEVDKLTPDAKFVEDLGADSLDVVELIMSFEEEFNIEIPDEDAEKIKTVGDVINYLNEKLK

SIPBD06D37BC6270FC2
type: Modified Residue Annotation
comment: O-(pantetheine 4'-phosphoryl)serine
range: 18634889068033582tt36tt36

18634889068033582tt36
type: Position
type: ExactPosition
position: 36
reference: MDREQRIKEIIADQLGVEVDKLTPDAKFVEDLGADSLDVVELIMSFEEEFNIEIPDEDAEKIKTVGDVINYLNEKLK

MDREQRIKEIIADQLGVEVDKLTPDAKFVEDLGADSLDVVELIMSFEEEFNIEIPDEDAEKIKTVGDVINYLNEKLK
type: Simple Sequence
modified: 2008-09-23
version: 1
mass: 8811

http://purl.uniprot.org/uniprot/B4U7T6#attribution-EBFCF1D44A6B78477DFBD33475E43FB0
manual: true
evidence: ECO_0000255
source: MF_01217

http://purl.uniprot.org/uniprot/B4U7T6#attribution-D13C97E04C041CF3567C01508AE538D1
manual: true
evidence: ECO_0000255
source: PRU00258

C0QUD3
type: Protein
reviewed: true
created: 2009-07-28
modified: 2023-09-13
version: 68
mnemonic: ACP_PERMH
citation: http://purl.uniprot.org/citations/19136599
recommended name: SIPF018D8BE7E205B4F
organism: http://purl.uniprot.org/taxonomy/123214
annotation: SIP7384EBE8221D4C52
annotation: SIP459EC51EE2D48D71
annotation: SIP4EF0648C6C1F77E1
annotation: SIP61B7FD3A26D27CB1
annotation: SIP78E1B332112FB080
annotation: PRO_1000164796
annotation: SIP6B9282507F1D4D45
annotation: SIPDBCE5890ABE2DF5C
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/275
classified with: http://purl.uniprot.org/keywords/596
classified with: http://purl.uniprot.org/keywords/597
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005737
classified with: GO_0000036
sequence: MEERIKEIIADQLGIDVEQIKPESKFVDDLGADSLDVVELIMAFEEEFDVEIPDEDAEKIQTVGDVINYIKEKKGE
proteome: Chromosome

C0QUD3-citation-19136599
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

DSM 14350 / EX-H1
type: Strain

SIPF018D8BE7E205B4F
type: Structured Name
full name: Acyl carrier protein
short name: ACP

acpP
type: Gene
locus name: PERMA_0508

SIP7384EBE8221D4C52
type: Function Annotation
comment: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

SIP61B7FD3A26D27CB1
type: PTM Annotation
comment: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.

SIP78E1B332112FB080
type: Similarity Annotation
comment: Belongs to the acyl carrier protein (ACP) family.

PRO_1000164796
type: Chain Annotation
comment: Acyl carrier protein
mass: 8656
range: 18911949320631086tt1tt76

18911949320631086tt1
type: Position
type: ExactPosition
position: 1
reference: MEERIKEIIADQLGIDVEQIKPESKFVDDLGADSLDVVELIMAFEEEFDVEIPDEDAEKIQTVGDVINYIKEKKGE

18911949320631086tt76
type: Position
type: ExactPosition
position: 76
reference: MEERIKEIIADQLGIDVEQIKPESKFVDDLGADSLDVVELIMAFEEEFDVEIPDEDAEKIQTVGDVINYIKEKKGE

SIP6B9282507F1D4D45
type: Domain Extent Annotation
comment: Carrier
range: 18911949320631086tt1tt74

18911949320631086tt74
type: Position
type: ExactPosition
position: 74
reference: MEERIKEIIADQLGIDVEQIKPESKFVDDLGADSLDVVELIMAFEEEFDVEIPDEDAEKIQTVGDVINYIKEKKGE

SIPDBCE5890ABE2DF5C
type: Modified Residue Annotation
comment: O-(pantetheine 4'-phosphoryl)serine
range: 18911949320631086tt34tt34

18911949320631086tt34
type: Position
type: ExactPosition
position: 34
reference: MEERIKEIIADQLGIDVEQIKPESKFVDDLGADSLDVVELIMAFEEEFDVEIPDEDAEKIQTVGDVINYIKEKKGE

MEERIKEIIADQLGIDVEQIKPESKFVDDLGADSLDVVELIMAFEEEFDVEIPDEDAEKIQTVGDVINYIKEKKGE
type: Simple Sequence
modified: 2009-05-05
version: 1
mass: 8656

http://purl.uniprot.org/uniprot/C0QUD3#attribution-EBFCF1D44A6B78477DFBD33475E43FB0
manual: true
evidence: ECO_0000255
source: MF_01217

http://purl.uniprot.org/uniprot/C0QUD3#attribution-D13C97E04C041CF3567C01508AE538D1
manual: true
evidence: ECO_0000255
source: PRU00258

B2V6T8
type: Protein
reviewed: true
created: 2009-04-14
modified: 2023-09-13
version: 87
mnemonic: ACP_SULSY
citation: http://purl.uniprot.org/citations/19136599
recommended name: SIPF018D8BE7E205B4F
organism: http://purl.uniprot.org/taxonomy/436114
annotation: SIP39C69A99CA878B08
annotation: SIP11D9746FED69A21D
annotation: SIP662E6275C10D904B
annotation: SIPF5F6A4E32B813D66
annotation: SIP24D7F1D246519C62
annotation: PRO_1000139069
annotation: SIPFF05779CA02D8213
annotation: SIPE5F71524FD840256
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/275
classified with: http://purl.uniprot.org/keywords/596
classified with: http://purl.uniprot.org/keywords/597
classified with: GO_0005737
classified with: GO_0000036
classified with: GO_0031177
sequence: MSVEQRVKEIIADQLGVEMEKITPEARFVDDLGADSLDVVELIMAFEEEFGVEIPDEDAEKIATVKDVLDYIKSKQG

B2V6T8-citation-19136599
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

YO3AOP1
type: Strain

SIPF018D8BE7E205B4F
type: Structured Name
full name: Acyl carrier protein
short name: ACP

acpP
type: Gene
locus name: SYO3AOP1_1672

SIP39C69A99CA878B08
type: Function Annotation
comment: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

SIPF5F6A4E32B813D66
type: PTM Annotation
comment: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.

SIP24D7F1D246519C62
type: Similarity Annotation
comment: Belongs to the acyl carrier protein (ACP) family.

PRO_1000139069
type: Chain Annotation
comment: Acyl carrier protein
mass: 8630
range: 18632694322968622tt1tt77

18632694322968622tt1
type: Position
type: ExactPosition
position: 1
reference: MSVEQRVKEIIADQLGVEMEKITPEARFVDDLGADSLDVVELIMAFEEEFGVEIPDEDAEKIATVKDVLDYIKSKQG

18632694322968622tt77
type: Position
type: ExactPosition
position: 77
reference: MSVEQRVKEIIADQLGVEMEKITPEARFVDDLGADSLDVVELIMAFEEEFGVEIPDEDAEKIATVKDVLDYIKSKQG

SIPFF05779CA02D8213
type: Domain Extent Annotation
comment: Carrier
range: 18632694322968622tt1tt76

18632694322968622tt76
type: Position
type: ExactPosition
position: 76
reference: MSVEQRVKEIIADQLGVEMEKITPEARFVDDLGADSLDVVELIMAFEEEFGVEIPDEDAEKIATVKDVLDYIKSKQG

SIPE5F71524FD840256
type: Modified Residue Annotation
comment: O-(pantetheine 4'-phosphoryl)serine
range: 18632694322968622tt36tt36

18632694322968622tt36
type: Position
type: ExactPosition
position: 36
reference: MSVEQRVKEIIADQLGVEMEKITPEARFVDDLGADSLDVVELIMAFEEEFGVEIPDEDAEKIATVKDVLDYIKSKQG

MSVEQRVKEIIADQLGVEMEKITPEARFVDDLGADSLDVVELIMAFEEEFGVEIPDEDAEKIATVKDVLDYIKSKQG
type: Simple Sequence
modified: 2008-07-01
version: 1
mass: 8630

http://purl.uniprot.org/uniprot/B2V6T8#attribution-EBFCF1D44A6B78477DFBD33475E43FB0
manual: true
evidence: ECO_0000255
source: MF_01217

http://purl.uniprot.org/uniprot/B2V6T8#attribution-D13C97E04C041CF3567C01508AE538D1
manual: true
evidence: ECO_0000255
source: PRU00258

O67506
type: Protein
reviewed: true
created: 2000-05-30
modified: 2023-09-13
version: 113
mnemonic: ADHS_AQUAE
old mnemonic: Y1554_AQUAE
old mnemonic: YF54_AQUAE
citation: http://purl.uniprot.org/citations/9537320
recommended name: SIPAA7671E57D8EB6BE
enzyme: http://purl.uniprot.org/enzyme/2.2.1.10
organism: http://purl.uniprot.org/taxonomy/224324
annotation: SIP02D4C57194DC5940
annotation: SIPA5354A240D3101C2
annotation: SIP236FBF589A14E029
annotation: SIP7506B28B8B40B136
annotation: PRO_0000138944
annotation: SIP11C49AE484141094
annotation: SIP099D7044DFFBA058
annotation: SIP690FD97F9F752F74
annotation: SIP65D5C2B8EAFF547F
annotation: SIPE8A19A53F4F0CFCE
annotation: SIPBC1847FDE1A57A29
annotation: SIP5D7124A2B9166912
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/57
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/704
classified with: http://purl.uniprot.org/keywords/808
classified with: GO_0004332
classified with: GO_0016836
classified with: GO_0016744
classified with: GO_0008652
classified with: GO_0009073
sequence: O67506-1
proteome: Chromosome

O67506-citation-9537320
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

VF5
type: Strain

COG1830
type: Resource
database: eggNOG
comment: Bacteria

cd00958
type: Resource
database: CDD
comment: DhnA
signature sequence match: CDD cd00958 match 1

MF_00960
type: Resource
database: HAMAP
comment: ADH_synthase
signature sequence match: HAMAP MF 00960 match 1

IPR010210
type: Resource
database: InterPro
comment: ADH_synthase

IPR002915
type: Resource
database: InterPro
comment: DeoC/FbaB/LacD_aldolase

IPR041720
type: Resource
database: InterPro
comment: FbaB-like

TIGR01949
type: Resource
database: NCBIfam
comment: ADH_synth
signature sequence match: NCBIfam TIGR01949 match 1

PTHR47916:SF1
type: Resource
database: PANTHER
comment: 3-HYDROXY-5-PHOSPHONOOXYPENTANE-2,4-DIONE THIOLASE-RELATED
signature sequence match: PANTHER PTHR47916:SF1 match 1

PTHR47916
type: Resource
database: PANTHER
comment: FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 1
signature sequence match: PANTHER PTHR47916 match 1

PF01791
type: Resource
database: Pfam
comment: DeoC
signature sequence match: Pfam PF01791 match 1

PIRSF038992
type: Resource
database: PIRSF
comment: Aldolase_Ia
signature sequence match: PIRSF PIRSF038992 match 1

SM01133
type: Resource
database: SMART
comment: DeoC
signature sequence match: SMART SM01133 match 1

SIPAA7671E57D8EB6BE
type: Structured Name
full name: 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
short name: ADH synthase
short name: ADHS
short name: ADTH synthase
ec name: 2.2.1.10

aroA'
type: Gene
locus name: aq_1554

SIP02D4C57194DC5940
type: Function Annotation
comment: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.

SIP236FBF589A14E029
type: Subunit Annotation
comment: Homodecamer.

SIP7506B28B8B40B136
type: Similarity Annotation
comment: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.

PRO_0000138944
type: Chain Annotation
comment: 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
mass: 28493
range: 22296133903595054tt1tt264

22296133903595054tt1
type: Position
type: ExactPosition
position: 1
reference: O67506-1

22296133903595054tt264
type: Position
type: ExactPosition
position: 264
reference: O67506-1

SIP11C49AE484141094
type: Active Site Annotation
comment: Proton acceptor
range: 22296133903595054tt26tt26

22296133903595054tt26
type: Position
type: ExactPosition
position: 26
reference: O67506-1

SIP099D7044DFFBA058
type: Active Site Annotation
comment: Proton donor
range: 22296133903595054tt146tt146

22296133903595054tt146
type: Position
type: ExactPosition
position: 146
reference: O67506-1

SIP690FD97F9F752F74
type: Active Site Annotation
comment: Schiff-base intermediate with substrate
range: 22296133903595054tt177tt177

22296133903595054tt177
type: Position
type: ExactPosition
position: 177
reference: O67506-1

22296133903595054tt30
type: Position
type: ExactPosition
position: 30
reference: O67506-1

22296133903595054tt148
type: Position
type: ExactPosition
position: 148
reference: O67506-1

22296133903595054tt202
type: Position
type: ExactPosition
position: 202
reference: O67506-1

22296133903595054tt203
type: Position
type: ExactPosition
position: 203
reference: O67506-1

22296133903595054tt230
type: Position
type: ExactPosition
position: 230
reference: O67506-1

22296133903595054tt231
type: Position
type: ExactPosition
position: 231
reference: O67506-1

O67506-1
type: Simple Sequence
modified: 1998-08-01
version: 1
mass: 28493
value: MGIGKEIRLERIMNRETRKTIIVPMDHGVSSGPIEGIVNIREAVEKVAEGGANAVVLHKGMVRAGHRGRGRDIGLIVHLSASTDLSPRKNDKVLVCTVEEAIRLGADAVSIHVNIGAEGEREMLKDFGYVSKVCEEWQMPLLAMVYGRGPKIENQYDPKVVAHCARVGAELGADIVKVPYTGDPETFKLAIEGSPIPVVIAGGPKMKSEREVLEMVQGAMQAGAAGLSIGRNIFQAKDPAKMVRAMSLIVHEGKSVEEAFEILK

http://purl.uniprot.org/uniprot/O67506#attribution-747553FCFC87C63E811F6B72254CEAA2
manual: true
evidence: ECO_0000255
source: MF_00960

O67434
type: Protein
reviewed: true
created: 2023-05-03
modified: 2023-06-28
version: 124
mnemonic: AGO_AQUAE
citation: http://purl.uniprot.org/citations/9537320
citation: http://purl.uniprot.org/citations/30698806
citation: http://purl.uniprot.org/citations/16061186
citation: http://purl.uniprot.org/citations/17027504
citation: http://purl.uniprot.org/citations/17130125
recommended name: SIP8FF025AE748CEE08
enzyme: http://purl.uniprot.org/enzyme/3.1.26.-
organism: http://purl.uniprot.org/taxonomy/224324
annotation: SIPE8A0BE8197D8009E
annotation: SIPA43DA58804A7A0A1
annotation: SIPBEC0E2D263DE7493
annotation: SIP0FF57BFCEAFE3B3A
annotation: SIPEFDA3EAC709F63B4
annotation: SIP44D353FBB9D2D258
annotation: SIPFFA6097EABC45D5D
annotation: PRO_0000457784
annotation: SIP8FC65B934DCB4B70
annotation: SIPB4A4950515B6D29B
annotation: SIPA37DCB28D2618E86
annotation: SIP0981D1D673ADF0C4
annotation: SIP7DC92DFEB948BAE9
annotation: SIPDC21C06A62EF0DE6
annotation: SIPBA12054C0E159F05
annotation: SIP145BFBE5BA06F47A
annotation: SIP8E0C26C1363D49F4
annotation: SIP1E30E3ED8FCFF2F5
annotation: SIP9A3ADE9E7EF28A43
annotation: SIP9929923ED2620CD7
annotation: SIP8D6300CD7B41E57E
annotation: SIPD71E155C0EEE7AD7
annotation: SIP31C72E4760A4A5DA
annotation: SIP9FDD73C4A695C149
annotation: SIP35245F49711F0236
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/238
classified with: http://purl.uniprot.org/keywords/255
classified with: http://purl.uniprot.org/keywords/464
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/694
classified with: GO_0003677
classified with: GO_0046872
classified with: GO_0003723
classified with: GO_0004521
sequence: O67434-1
proteome: Chromosome

O67434-citation-9537320
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

VF5
type: Strain

O67434-citation-30698806
type: Citation Statement
scope: BIOTECHNOLOGY

O67434-citation-16061186
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) IN COMPLEX WITH CALCIUM
scope: FUNCTION
scope: CATALYTIC ACTIVITY
scope: COFACTOR
scope: BIOPHYSICOCHEMICAL PROPERTIES
scope: SUBUNIT
scope: DOMAIN
scope: NUCLEIC ACID-BINDING

O67434-citation-17027504
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) IN COMPLEX WITH RNA
scope: FUNCTION
scope: DOMAIN
scope: MUTAGENESIS OF TYR-119

O67434-citation-17130125
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS)
scope: DOMAIN
scope: SSDNA-BINDING

1YVU
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.90
chain sequence mapping: PDB 1YVU tt1tt706

PDB 1YVU tt1tt706
chain: A=1-706

2F8S
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 3.00
chain sequence mapping: PDB 2F8S tt1tt706

PDB 2F8S tt1tt706
chain: A/B=1-706

2F8T
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 3.10
chain sequence mapping: PDB 2F8T tt1tt706

PDB 2F8T tt1tt706
chain: A/B=1-706

2NUB
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 3.20
chain sequence mapping: PDB 2NUB tt1tt706

PDB 2NUB tt1tt706
chain: A=1-706

COG1431
type: Resource
database: eggNOG
comment: Bacteria

cd04659
type: Resource
database: CDD
comment: Piwi_piwi-like_ProArk
signature sequence match: CDD cd04659 match 1

http://purl.uniprot.org/gene3d/2.30.340.10
type: Resource
database: Gene3D
comment: PAZ domain superfamily
signature sequence match: Gene3D 2.30.340.10 match 1

http://purl.uniprot.org/gene3d/3.30.420.10
type: Resource
database: Gene3D
comment: Ribonuclease H-like superfamily/Ribonuclease H
signature sequence match: Gene3D 3.30.420.10 match 1

IPR041659
type: Resource
database: InterPro
comment: Paz_1

IPR036085
type: Resource
database: InterPro
comment: PAZ_dom_sf

IPR003165
type: Resource
database: InterPro
comment: Piwi

IPR012337
type: Resource
database: InterPro
comment: RNaseH-like_sf

IPR036397
type: Resource
database: InterPro
comment: RNaseH_sf

PF18349
type: Resource
database: Pfam
comment: PAZ_4
signature sequence match: Pfam PF18349 match 1

PF02171
type: Resource
database: Pfam
comment: Piwi
signature sequence match: Pfam PF02171 match 1

SM00950
type: Resource
database: SMART
comment: Piwi
signature sequence match: SMART SM00950 match 1

SSF101690
type: Resource
database: SUPFAM
comment: PAZ domain
signature sequence match: SUPFAM SSF101690 match 1

SSF53098
type: Resource
database: SUPFAM
comment: Ribonuclease H-like
signature sequence match: SUPFAM SSF53098 match 1

PS50821
type: Resource
database: PROSITE
comment: PAZ
signature sequence match: PROSITE PS50821 match 1

PS50822
type: Resource
database: PROSITE
comment: PIWI
signature sequence match: PROSITE PS50822 match 1

SIP8FF025AE748CEE08
type: Structured Name
full name: Protein argonaute
short name: AaAgo
ec name: 3.1.26.-

ago
type: Gene
locus name: aq_1447

SIPE8A0BE8197D8009E
type: Function Annotation
comment: A DNA-guided RNA endonuclease. Uses short ssDNA sequences as guides (gDNA) to bind complementary target strands, resulting in cleavage of the target RNA. The cleavage site is 10 nucleotides downstream of the residue base paired with the 5'-end of the gDNA (PubMed:16061186). Binds ssDNA better than ssRNA, binds dsDNA and DNA-RNA hybrids but does not bind dsRNA (PubMed:16061186). A 2 nucleotide 3'-overhang (possibly on the guide strand) may help load nucleic acids into the complex (PubMed:17027504) (Probable).

SIPA43DA58804A7A0A1
type: Cofactor Annotation
comment: Mg(2+) is the preferred cation for DNA-guided cleavage while Mn(2+) supports both DNA- and RNA-guided cleavage of an RNA target. Ca(2+), which is found in the structure, does not support cleavage (PubMed:16061186). Cleavage probaby requires 2 divalent metal cations (By similarity).
cofactor: CHEBI_18420

SIPBEC0E2D263DE7493
type: Temperature Dependence Annotation
comment: Optimum temperature is 55 degrees Celsius.

SIP0FF57BFCEAFE3B3A
type: Domain Annotation
comment: Has 4 domains; N-terminal, PAZ, Mid and PIWI. The N-terminal and PAZ domain are joined by linker 1, the PAZ and Mid domain are joined by linker 2. The domains assemble in 2 lobes; the PAZ lobe consists of the N-terminal, L1, PAZ and L2 domains, while the PIWI lobe has the Mid and PIWI domains. The PIWI box is exposed on the surface of the protein. The PIWI domain assumes an RNase H fold and has the catalytic residues (PubMed:16061186, PubMed:17027504, PubMed:17130125). The N-terminal and PAZ domains are relatively mobile and move further apart when in complex with RNA (PubMed:17027504, PubMed:17130125).

SIPEFDA3EAC709F63B4
type: Biotechnology Annotation
comment: Can be used for genome editing.

SIP44D353FBB9D2D258
type: Annotation
comment: In the structure with dsRNA, the nucleic acid is not found in the expected channel, only the two 3'-terminal residues interact in a possibly physiological manner with the protein.

SIPFFA6097EABC45D5D
type: Similarity Annotation
comment: Belongs to the argonaute family. Long pAgo subfamily.

PRO_0000457784
type: Chain Annotation
comment: Protein argonaute
mass: 83122
range: 22296133887013934tt1tt706

22296133887013934tt1
type: Position
type: ExactPosition
position: 1
reference: O67434-1

22296133887013934tt706
type: Position
type: ExactPosition
position: 706
reference: O67434-1

SIP8FC65B934DCB4B70
type: Domain Extent Annotation
comment: PAZ
range: 22296133887013934tt168tt259

22296133887013934tt168
type: Position
type: ExactPosition
position: 168
reference: O67434-1

22296133887013934tt259
type: Position
type: ExactPosition
position: 259
reference: O67434-1

SIPB4A4950515B6D29B
type: Domain Extent Annotation
comment: Piwi
range: 22296133887013934tt419tt694

22296133887013934tt419
type: Position
type: ExactPosition
position: 419
reference: O67434-1

22296133887013934tt694
type: Position
type: ExactPosition
position: 694
reference: O67434-1

SIPA37DCB28D2618E86
type: Region Annotation
comment: N-terminal domain
range: 22296133887013934tt1tt108

22296133887013934tt108
type: Position
type: ExactPosition
position: 108
reference: O67434-1

SIP0981D1D673ADF0C4
type: Region Annotation
comment: Linker L1
range: 22296133887013934tt109tt165

22296133887013934tt109
type: Position
type: ExactPosition
position: 109
reference: O67434-1

22296133887013934tt165
type: Position
type: ExactPosition
position: 165
reference: O67434-1

SIP7DC92DFEB948BAE9
type: Region Annotation
comment: Linker L2
range: 22296133887013934tt263tt334

22296133887013934tt263
type: Position
type: ExactPosition
position: 263
reference: O67434-1

22296133887013934tt334
type: Position
type: ExactPosition
position: 334
reference: O67434-1

SIPDC21C06A62EF0DE6
type: Region Annotation
comment: Mid domain
range: 22296133887013934tt335tt448

22296133887013934tt335
type: Position
type: ExactPosition
position: 335
reference: O67434-1

22296133887013934tt448
type: Position
type: ExactPosition
position: 448
reference: O67434-1

SIPBA12054C0E159F05
type: Region Annotation
comment: PIWI domain
range: 22296133887013934tt449tt706

22296133887013934tt449
type: Position
type: ExactPosition
position: 449
reference: O67434-1

SIP145BFBE5BA06F47A
type: Region Annotation
comment: PIWI box
range: 22296133887013934tt612tt650

22296133887013934tt612
type: Position
type: ExactPosition
position: 612
reference: O67434-1

22296133887013934tt650
type: Position
type: ExactPosition
position: 650
reference: O67434-1

22296133887013934tt502
type: Position
type: ExactPosition
position: 502
reference: O67434-1

22296133887013934tt541
type: Position
type: ExactPosition
position: 541
reference: O67434-1

22296133887013934tt571
type: Position
type: ExactPosition
position: 571
reference: O67434-1

22296133887013934tt683
type: Position
type: ExactPosition
position: 683
reference: O67434-1

SIP35245F49711F0236
type: Mutagenesis Annotation
comment: No change in DNA-guided RNA cleavage or ssRNA binding, decreased recognition of the 3'-overhang of a dsRNA duplex.
substitution: A
range: 22296133887013934tt119tt119

22296133887013934tt119
type: Position
type: ExactPosition
position: 119
reference: O67434-1

1
subclass of: CHEBI_29035

2
subclass of: CHEBI_29035

O67434-1
type: Simple Sequence
modified: 1998-08-01
version: 1
mass: 83122
value: MGKEALLNLYRIEYRPKDTTFTVFKPTHEIQKEKLNKVRWRVFLQTGLPTFRREDEFWCAGKVEKDTLYLTLSNGEIVELKRVGEEEFRGFQNERECQELFRDFLTKTKVKDKFISDFYKKFRDKITVQGKNRKIALIPEVNEKVLKSEEGYFLLHLDLKFRIQPFETLQTLLERNDFNPKRIRVKPIGIDFVGRVQDVFKAKEKGEEFFRLCMERSTHKSSKKAWEELLKNRELREKAFLVVLEKGYTYPATILKPVLTYENLEDEERNEVADIVRMEPGKRLNLIRYILRRYVKALRDYGWYISPEEERAKGKLNFKDTVLDAKGKNTKVITNLRKFLELCRPFVKKDVLSVEIISVSVYKKLEWRKEEFLKELINFLKNKGIKLKIKGKSLILAQTREEAKEKLIPVINKIKDVDLVIVFLEEYPKVDPYKSFLLYDFVKRELLKKMIPSQVILNRTLKNENLKFVLLNVAEQVLAKTGNIPYKLKEIEGKVDAFVGIDISRITRDGKTVNAVAFTKIFNSKGELVRYYLTSYPAFGEKLTEKAIGDVFSLLEKLGFKKGSKIVVHRDGRLYRDEVAAFKKYGELYGYSLELLEIIKRNNPRFFSNEKFIKGYFYKLSEDSVILATYNQVYEGTHQPIKVRKVYGELPVEVLCSQILSLTLMNYSSFQPIKLPATVHYSDKITKLMLRGIEPIKKEGDIMYWL

http://purl.uniprot.org/uniprot/O67434#attribution-5E0E14382DDD2549B381D9E8EE5DB44B
creator: UniProtKB
manual: true
evidence: ECO_0000314
source: http://purl.uniprot.org/citations/16061186

http://purl.uniprot.org/uniprot/O67434#attribution-A99D2AD579424351642138864482D94C
manual: true
evidence: ECO_0000250
source: Q746M7

http://purl.uniprot.org/uniprot/O67434#attribution-2B0584DC89DF2717F04F57D64BE0E3BF
manual: true
evidence: ECO_0000255
source: PRU00142

http://purl.uniprot.org/uniprot/O67434#attribution-FF524CE07233C80F0A22AC64EFB61512
manual: true
evidence: ECO_0000255
source: PRU00150

http://purl.uniprot.org/uniprot/O67434#attribution-0544CFCB01F2677D14952CD688CF96F8
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/16061186

http://purl.uniprot.org/uniprot/O67434#attribution-1F50B012F8C5AFBA2E9B8A1016CA8099
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/17027504

http://purl.uniprot.org/uniprot/O67434#attribution-06209B628430E845A90604D145202994
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/17130125

http://purl.uniprot.org/uniprot/O67434#attribution-867BFB05BCEBBD13460808D61F074009
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/30698806

http://purl.uniprot.org/uniprot/O67434#attribution-EDDE09105742699D79CC3012844415F3
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/16061186

http://purl.uniprot.org/uniprot/O67434#attribution-824DFF672B69422BA81D4B26C2725019
manual: true
evidence: ECO_0000305

http://purl.uniprot.org/uniprot/O67434#attribution-593EF90E445BA2020D3977CD07533927
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/16061186

http://purl.uniprot.org/uniprot/O67434#attribution-79BF09C225E4FE13EC2603472ED640BB
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/17027504

http://purl.uniprot.org/uniprot/O67434#attribution-4C6DE580DD70E581C50855D253B561C1
manual: true
evidence: ECO_0000312
source: AAC07406.1

http://purl.uniprot.org/uniprot/O67434#attribution-0EBFBC9A6132BA533B3FE2EE1437E30F
manual: true
evidence: ECO_0000312
source: 2F8S

http://purl.uniprot.org/uniprot/O67434#attribution-B827A640C4A5B042F308F2699C6B0A15
manual: true
evidence: ECO_0000312
source: 2F8T

http://purl.uniprot.org/uniprot/O67434#attribution-0BCCB3450B737387958415EE0DD4C7E7
manual: true
evidence: ECO_0007744
source: 1YVU

http://purl.uniprot.org/uniprot/O67434#attribution-8C8DB28656F45B76BA5FF2A0B90AC9CE
manual: true
evidence: ECO_0007744
source: 2F8S

http://purl.uniprot.org/uniprot/O67434#attribution-79549DAA1F0DC9F3AEE4AC4DD047595F
manual: true
evidence: ECO_0007744
source: 2F8T

http://purl.uniprot.org/uniprot/O67434#attribution-0A280957F6FB709181032230C1F6ED79
manual: true
evidence: ECO_0007744
source: 2NUB

O67221
type: Protein
reviewed: true
created: 2000-05-30
modified: 2023-09-13
version: 128
mnemonic: AK_AQUAE
citation: http://purl.uniprot.org/citations/9537320
recommended name: SIP6870072937F68FA6
alternative name: SIP3A23751A818A6815
enzyme: http://purl.uniprot.org/enzyme/2.7.2.4
organism: http://purl.uniprot.org/taxonomy/224324
annotation: SIP3CBC97C7557756F1
annotation: SIPDF97D671EDCEFB89
annotation: SIPCB6BEEFCEBA00F93
annotation: SIP5AC5BB2C50C90536
annotation: SIP08CFB40E3B473270
annotation: PRO_0000066671
annotation: SIP3E5CE33062A35F5B
annotation: SIP1B063463091C030C
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/220
classified with: http://purl.uniprot.org/keywords/418
classified with: http://purl.uniprot.org/keywords/457
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/677
classified with: GO_0005829
classified with: GO_0004072
classified with: GO_0005524
classified with: GO_0019877
classified with: GO_0009090
classified with: GO_0009089
classified with: GO_0016310
classified with: GO_0009088
sequence: O67221-1
proteome: Chromosome

O67221-citation-9537320
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

VF5
type: Strain

COG0527
type: Resource
database: eggNOG
comment: Bacteria

cd04261
type: Resource
database: CDD
comment: AAK_AKii-LysC-BS
signature sequence match: CDD cd04261 match 1

cd04913
type: Resource
database: CDD
comment: ACT_AKii-LysC-BS-like_1
signature sequence match: CDD cd04913 match 1

cd04936
type: Resource
database: CDD
comment: ACT_AKii-LysC-BS-like_2
signature sequence match: CDD cd04936 match 1

http://purl.uniprot.org/gene3d/3.40.1160.10
type: Resource
database: Gene3D
comment: Acetylglutamate kinase-like
signature sequence match: Gene3D 3.40.1160.10 match 1

http://purl.uniprot.org/gene3d/3.30.2130.10
type: Resource
database: Gene3D
comment: VC0802-like
signature sequence match: Gene3D 3.30.2130.10 match 1

IPR036393
type: Resource
database: InterPro
comment: AceGlu_kinase-like_sf

IPR045865
type: Resource
database: InterPro
comment: ACT-like_dom_sf

IPR002912
type: Resource
database: InterPro
comment: ACT_dom

IPR041740
type: Resource
database: InterPro
comment: AKii-LysC-BS

IPR001048
type: Resource
database: InterPro
comment: Asp/Glu/Uridylate_kinase

IPR005260
type: Resource
database: InterPro
comment: Asp_kin_monofn

IPR001341
type: Resource
database: InterPro
comment: Asp_kinase

IPR018042
type: Resource
database: InterPro
comment: Aspartate_kinase_CS

IPR027795
type: Resource
database: InterPro
comment: CASTOR_ACT_dom

TIGR00656
type: Resource
database: NCBIfam
comment: asp_kin_monofn
signature sequence match: NCBIfam TIGR00656 match 1

TIGR00657
type: Resource
database: NCBIfam
comment: asp_kinases
signature sequence match: NCBIfam TIGR00657 match 1

PTHR21499
type: Resource
database: PANTHER
comment: ASPARTATE KINASE
signature sequence match: PANTHER PTHR21499 match 1

PTHR21499:SF3
type: Resource
database: PANTHER
comment: ASPARTOKINASE 1
signature sequence match: PANTHER PTHR21499:SF3 match 1

PF00696
type: Resource
database: Pfam
comment: AA_kinase
signature sequence match: Pfam PF00696 match 1

PF01842
type: Resource
database: Pfam
comment: ACT
signature sequence match: Pfam PF01842 match 1

PF13840
type: Resource
database: Pfam
comment: ACT_7
signature sequence match: Pfam PF13840 match 1

PIRSF000726
type: Resource
database: PIRSF
comment: Asp_kin
signature sequence match: PIRSF PIRSF000726 match 1

SSF55021
type: Resource
database: SUPFAM
comment: ACT-like
signature sequence match: SUPFAM SSF55021 match 1
signature sequence match: SUPFAM SSF55021 match 2

SSF53633
type: Resource
database: SUPFAM
comment: Carbamate kinase-like
signature sequence match: SUPFAM SSF53633 match 1

PS51671
type: Resource
database: PROSITE
comment: ACT
signature sequence match: PROSITE PS51671 match 1
signature sequence match: PROSITE PS51671 match 2

PS00324
type: Resource
database: PROSITE
comment: ASPARTOKINASE
signature sequence match: PROSITE PS00324 match 1

SIP6870072937F68FA6
type: Structured Name
full name: Aspartokinase
ec name: 2.7.2.4

SIP3A23751A818A6815
type: Structured Name
full name: Aspartate kinase

lysC
type: Gene
locus name: aq_1152

SIP08CFB40E3B473270
type: Similarity Annotation
comment: Belongs to the aspartokinase family.

PRO_0000066671
type: Chain Annotation
comment: Aspartokinase
mass: 45519
range: 22296133853393198tt1tt415

22296133853393198tt1
type: Position
type: ExactPosition
position: 1
reference: O67221-1

22296133853393198tt415
type: Position
type: ExactPosition
position: 415
reference: O67221-1

SIP3E5CE33062A35F5B
type: Domain Extent Annotation
comment: ACT 1
range: 22296133853393198tt263tt337

22296133853393198tt263
type: Position
type: ExactPosition
position: 263
reference: O67221-1

22296133853393198tt337
type: Position
type: ExactPosition
position: 337
reference: O67221-1

SIP1B063463091C030C
type: Domain Extent Annotation
comment: ACT 2
range: 22296133853393198tt343tt415

22296133853393198tt343
type: Position
type: ExactPosition
position: 343
reference: O67221-1

O67221-1
type: Simple Sequence
modified: 1998-08-01
version: 1
mass: 45519
value: MKILVQKFGGTSVGTLERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELAKKVHPRPPEREMDTLLAVGEQKAIALFAMTLNKLGYPAVSLCGWQVPIITDNVHTKARIRKIGISRLLSLIEEGYIPVVAGFQGVTEDWEITTLGRGGSDTTAVALAAALKADCEINTDVPGVFTADPRIVPNAKKIKKISYEEMLELASLGAKVMQIRSVEFAAKYNVRIHVRSTFSEEEGTWIVPEDEVMEKVAVRGITVDTKETRFTVVRVPDKPGIAAEIFKALGDAHIVVDMIVQNVSHEGYTDMSFTVNKTDADKAEEIVKKIAQKIGAKEVVRDDKVAKISIVGIGMKSAYGVAGRMFDILARNGINIKAISTSEIKISCLIDEKYAELAVRALHEEFIEEMEEFETINGKNKE

http://purl.uniprot.org/uniprot/O67221#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/O67221#attribution-3A0666527C5361B1DBF8209333823266
manual: true
evidence: ECO_0000255
source: PRU01007

http://purl.uniprot.org/uniprot/O67221#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

O67687
type: Protein
reviewed: true
created: 1998-12-15
modified: 2023-09-13
version: 133
mnemonic: ALR_AQUAE
citation: http://purl.uniprot.org/citations/9537320
recommended name: SIPA9A4E98D933D1F32
enzyme: http://purl.uniprot.org/enzyme/5.1.1.1
organism: http://purl.uniprot.org/taxonomy/224324
annotation: SIP9D4A098F20C5448F
annotation: SIPAA6981DE39AD78B9
annotation: SIPC7601B36AFCC528B
annotation: SIPFC1669A4F9516983
annotation: SIP92C06BC6CF108159
annotation: PRO_0000114495
annotation: SIP3696518961197F7C
annotation: SIP463CD6749FB76EA3
annotation: SIPCF7DEA4726520B4B
annotation: SIPBB26B883A3B589B1
annotation: SIP24C666E2A2F2E0C9
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/413
classified with: http://purl.uniprot.org/keywords/663
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005829
classified with: GO_0008784
classified with: GO_0030170
classified with: GO_0030632
sequence: O67687-1
proteome: Chromosome

O67687-citation-9537320
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

VF5
type: Strain

COG0787
type: Resource
database: eggNOG
comment: Bacteria

cd00430
type: Resource
database: CDD
comment: PLPDE_III_AR
signature sequence match: CDD cd00430 match 1

http://purl.uniprot.org/gene3d/3.20.20.10
type: Resource
database: Gene3D
comment: Alanine racemase
signature sequence match: Gene3D 3.20.20.10 match 1

MF_01201
type: Resource
database: HAMAP
comment: Ala_racemase
signature sequence match: HAMAP MF 01201 match 1

IPR000821
type: Resource
database: InterPro
comment: Ala_racemase

IPR009006
type: Resource
database: InterPro
comment: Ala_racemase/Decarboxylase_C

IPR011079
type: Resource
database: InterPro
comment: Ala_racemase_C

IPR001608
type: Resource
database: InterPro
comment: Ala_racemase_N

IPR020622
type: Resource
database: InterPro
comment: Ala_racemase_pyridoxalP-BS

IPR029066
type: Resource
database: InterPro
comment: PLP-binding_barrel

TIGR00492
type: Resource
database: NCBIfam
comment: alr
signature sequence match: NCBIfam TIGR00492 match 1

PTHR30511
type: Resource
database: PANTHER
comment: ALANINE RACEMASE
signature sequence match: PANTHER PTHR30511 match 1

PTHR30511:SF0
type: Resource
database: PANTHER
comment: ALANINE RACEMASE, CATABOLIC-RELATED
signature sequence match: PANTHER PTHR30511:SF0 match 1

PF00842
type: Resource
database: Pfam
comment: Ala_racemase_C
signature sequence match: Pfam PF00842 match 1

PF01168
type: Resource
database: Pfam
comment: Ala_racemase_N
signature sequence match: Pfam PF01168 match 1

PR00992
type: Resource
database: PRINTS
comment: ALARACEMASE

SM01005
type: Resource
database: SMART
comment: Ala_racemase_C
signature sequence match: SMART SM01005 match 1

SSF50621
type: Resource
database: SUPFAM
comment: Alanine racemase C-terminal domain-like
signature sequence match: SUPFAM SSF50621 match 1

SSF51419
type: Resource
database: SUPFAM
comment: PLP-binding barrel
signature sequence match: SUPFAM SSF51419 match 1

PS00395
type: Resource
database: PROSITE
comment: ALANINE_RACEMASE
signature sequence match: PROSITE PS00395 match 1

SIPA9A4E98D933D1F32
type: Structured Name
full name: Alanine racemase
ec name: 5.1.1.1

alr
type: Gene
locus name: aq_1827

SIP9D4A098F20C5448F
type: Function Annotation
comment: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

SIP92C06BC6CF108159
type: Similarity Annotation
comment: Belongs to the alanine racemase family.

PRO_0000114495
type: Chain Annotation
comment: Alanine racemase
mass: 38203
range: 22296133920896814tt1tt338

22296133920896814tt1
type: Position
type: ExactPosition
position: 1
reference: O67687-1

22296133920896814tt338
type: Position
type: ExactPosition
position: 338
reference: O67687-1

SIP3696518961197F7C
type: Active Site Annotation
comment: Proton acceptor; specific for D-alanine
range: 22296133920896814tt33tt33

22296133920896814tt33
type: Position
type: ExactPosition
position: 33
reference: O67687-1

SIP463CD6749FB76EA3
type: Active Site Annotation
comment: Proton acceptor; specific for L-alanine
range: 22296133920896814tt236tt236

22296133920896814tt236
type: Position
type: ExactPosition
position: 236
reference: O67687-1

22296133920896814tt126
type: Position
type: ExactPosition
position: 126
reference: O67687-1

22296133920896814tt284
type: Position
type: ExactPosition
position: 284
reference: O67687-1

SIP24C666E2A2F2E0C9
type: Modified Residue Annotation
comment: N6-(pyridoxal phosphate)lysine
range: 22296133920896814tt33tt33

substrate

O67687-1
type: Simple Sequence
modified: 1998-08-01
version: 1
mass: 38203
value: MPRAILEINSERIRHNVKKLSEFSGKKVIAVIKADAYGIGSIQMAKILEPIEEVDAFAVACVEEGVELRKMGIKKEILILGGVLKDEVPLVEEYFLTPVVSDIEHLRAIGNRDIKFHVKYDTGMGRLGFLNEVIHDPRVEGIMSHLSSPADEEFSKLQIKKFEEIVKKYTKVEKIHMESSAGVVYRVPFTTHIRVGLAMYGEKPLKNYPVDIKPALTLKAKLISVKELPENYPVSYSRTYVTKKKTKTGVVAFGYADGLMKTLSNRSYLLYKGEKLPIFGNITMDMTIVDLKNTDAKVGDWVYVVNEERTFTELAREAGTIPYELMCNLSKRIKRVVV

http://purl.uniprot.org/uniprot/O67687#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/O67687#attribution-35F80A75CD326B6A74A2E2D4A39D726C
manual: true
evidence: ECO_0000255
source: MF_01201

Q9RER4
type: Protein
reviewed: true
created: 2002-03-05
modified: 2023-09-13
version: 85
mnemonic: ALR_AQUPY
citation: SIP3C11CD9FEFBC20C4
recommended name: SIPA9A4E98D933D1F32
enzyme: http://purl.uniprot.org/enzyme/5.1.1.1
organism: http://purl.uniprot.org/taxonomy/2714
annotation: SIP34E28C336162B7E8
annotation: SIPF9D574A45B78145E
annotation: SIP2FFFCC3952573817
annotation: SIP8E70B581AEB9E075
annotation: SIP979E22F8EF62F05B
annotation: SIP407F2691E81A51E3
annotation: PRO_0000114496
annotation: SIP5C2921643B37776B
annotation: SIP11A7458ADAC79298
annotation: SIP30BB8314D0B1466B
annotation: SIP6522DFDD583468E9
annotation: SIPF3865FB8BBE3F832
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/413
classified with: http://purl.uniprot.org/keywords/663
classified with: GO_0008784
classified with: GO_0030170
classified with: GO_0030632
sequence: Q9RER4-1

Q9RER4-citation-SIP3C11CD9FEFBC20C4
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: FUNCTION
scope: CATALYTIC ACTIVITY
scope: COFACTOR
scope: PATHWAY

SIPA9A4E98D933D1F32
type: Structured Name
full name: Alanine racemase
ec name: 5.1.1.1

alr
type: Gene

SIP34E28C336162B7E8
type: Function Annotation
comment: Catalyzes the interconversion of L-alanine and D-alanine.

SIP979E22F8EF62F05B
type: Annotation
comment: Strong thermostability.

SIP407F2691E81A51E3
type: Similarity Annotation
comment: Belongs to the alanine racemase family.

PRO_0000114496
type: Chain Annotation
comment: Alanine racemase
mass: 39014
range: 22862498626679854tt1tt341

22862498626679854tt1
type: Position
type: ExactPosition
position: 1
reference: Q9RER4-1

22862498626679854tt341
type: Position
type: ExactPosition
position: 341
reference: Q9RER4-1

SIP5C2921643B37776B
type: Active Site Annotation
comment: Proton acceptor; specific for D-alanine
range: 22862498626679854tt33tt33

22862498626679854tt33
type: Position
type: ExactPosition
position: 33
reference: Q9RER4-1

SIP11A7458ADAC79298
type: Active Site Annotation
comment: Proton acceptor; specific for L-alanine
range: 22862498626679854tt236tt236

22862498626679854tt236
type: Position
type: ExactPosition
position: 236
reference: Q9RER4-1

22862498626679854tt126
type: Position
type: ExactPosition
position: 126
reference: Q9RER4-1

22862498626679854tt284
type: Position
type: ExactPosition
position: 284
reference: Q9RER4-1

SIPF3865FB8BBE3F832
type: Modified Residue Annotation
comment: N6-(pyridoxal phosphate)lysine
range: 22862498626679854tt33tt33

substrate

Q9RER4-1
type: Simple Sequence
modified: 2000-05-01
version: 1
mass: 39014
value: MRRAVLEILEERIIHNVKEIHRFSGKRIIAVVKANAYGIGVREVSRILEGLEEVDAFAVACTQEGVELRECGIKKKILILGGILEEDVKLLEEYDLTPVISDPEHLKVLKDRNIKFHVKYDTGMGRLGFTNEIIKDPRVEGVMSHFSSPADRNFSKLQIKRFEEILKNYEKVKYIHLESSAGLIYRVPFTTHVRVGLAIYGEKPLKDYPLEVKPALRLRARLISVKELPENYPVSYGRTYITKRKTKLGVVAFGYADGLMKTLSNRSFLIFEGRKVPIIGNITMDMTMVDLSGTEARTGDWVYIVNEERSFTPLARDAGTIPYEIMCNLSRRVERLVIKKR

http://purl.uniprot.org/uniprot/Q9RER4#attribution-35F80A75CD326B6A74A2E2D4A39D726C
manual: true
evidence: ECO_0000255
source: MF_01201

http://purl.uniprot.org/uniprot/Q9RER4#attribution-A08B03C0B4501B8451C9AA159194CEE9
manual: true
evidence: ECO_0000269
source: SIP3C11CD9FEFBC20C4

O67868
type: Protein
reviewed: true
created: 2000-12-01
modified: 2023-06-28
version: 127
mnemonic: AMPA_AQUAE
citation: http://purl.uniprot.org/citations/9537320
recommended name: SIP4C2E197687D5A48E
alternative name: SIP8E066A1821A9A88A
alternative name: SIP2BA06BA51D2DD54D
enzyme: http://purl.uniprot.org/enzyme/3.4.11.1
enzyme: http://purl.uniprot.org/enzyme/3.4.11.10
organism: http://purl.uniprot.org/taxonomy/224324
annotation: SIP534B94CA8B9FE159
annotation: SIPDD073008F39C65CC
annotation: SIP040FB33AC22E633B
annotation: SIP79F3ABE4C7583617
annotation: SIP3A4953E1795AECFF
annotation: SIPDB2A685CC3503F8B
annotation: PRO_0000165717
annotation: SIP45CC25179CD8B1D8
annotation: SIP4C090E5547EF313D
annotation: SIPA04F6DA30A80D287
annotation: SIPE13383DD7BD961E2
annotation: SIPE04D6974D9D78E81
annotation: SIPCD1573592B4A86B1
annotation: SIPFA7068D32B941652
annotation: SIP41440D17E7164040
annotation: SIPA084808FA5F7F06B
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/31
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/464
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005737
classified with: GO_0030145
classified with: GO_0070006
classified with: GO_0008233
classified with: GO_0006508
sequence: O67868-1
proteome: Chromosome

O67868-citation-9537320
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

VF5
type: Strain

COG0260
type: Resource
database: eggNOG
comment: Bacteria

cd00433
type: Resource
database: CDD
comment: Peptidase_M17
signature sequence match: CDD cd00433 match 1

http://purl.uniprot.org/gene3d/3.40.220.10
type: Resource
database: Gene3D
comment: Leucine Aminopeptidase, subunit E, domain 1
signature sequence match: Gene3D 3.40.220.10 match 1

http://purl.uniprot.org/gene3d/3.40.630.10
type: Resource
database: Gene3D
comment: Zn peptidases
signature sequence match: Gene3D 3.40.630.10 match 1

MF_00181
type: Resource
database: HAMAP
comment: Cytosol_peptidase_M17
signature sequence match: HAMAP MF 00181 match 1

IPR011356
type: Resource
database: InterPro
comment: Leucine_aapep/pepB

IPR043472
type: Resource
database: InterPro
comment: Macro_dom-like

IPR000819
type: Resource
database: InterPro
comment: Peptidase_M17_C

IPR023042
type: Resource
database: InterPro
comment: Peptidase_M17_leu_NH2_pept

IPR008283
type: Resource
database: InterPro
comment: Peptidase_M17_N

PTHR11963:SF23
type: Resource
database: PANTHER
comment: CYTOSOL AMINOPEPTIDASE
signature sequence match: PANTHER PTHR11963:SF23 match 1

PTHR11963
type: Resource
database: PANTHER
comment: LEUCINE AMINOPEPTIDASE-RELATED
signature sequence match: PANTHER PTHR11963 match 1

PF00883
type: Resource
database: Pfam
comment: Peptidase_M17
signature sequence match: Pfam PF00883 match 1

PF02789
type: Resource
database: Pfam
comment: Peptidase_M17_N
signature sequence match: Pfam PF02789 match 1

PR00481
type: Resource
database: PRINTS
comment: LAMNOPPTDASE

SSF52949
type: Resource
database: SUPFAM
comment: Macro domain-like
signature sequence match: SUPFAM SSF52949 match 1

SSF53187
type: Resource
database: SUPFAM
comment: Zn-dependent exopeptidases
signature sequence match: SUPFAM SSF53187 match 1

PS00631
type: Resource
database: PROSITE
comment: CYTOSOL_AP
signature sequence match: PROSITE PS00631 match 1

SIP4C2E197687D5A48E
type: Structured Name
full name: Probable cytosol aminopeptidase
ec name: 3.4.11.1

SIP8E066A1821A9A88A
type: Structured Name
full name: Leucine aminopeptidase
short name: LAP
ec name: 3.4.11.10

SIP2BA06BA51D2DD54D
type: Structured Name
full name: Leucyl aminopeptidase

pepA
type: Gene
locus name: aq_2099

SIP534B94CA8B9FE159
type: Function Annotation
comment: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity).

SIP79F3ABE4C7583617
type: Cofactor Annotation
comment: Binds 2 manganese ions per subunit.
cofactor: CHEBI_29035

SIPDB2A685CC3503F8B
type: Similarity Annotation
comment: Belongs to the peptidase M17 family.

PRO_0000165717
type: Chain Annotation
comment: Probable cytosol aminopeptidase
mass: 54543
range: 22296133954320430tt1tt493

22296133954320430tt1
type: Position
type: ExactPosition
position: 1
reference: O67868-1

22296133954320430tt493
type: Position
type: ExactPosition
position: 493
reference: O67868-1

22296133954320430tt269
type: Position
type: ExactPosition
position: 269
reference: O67868-1

22296133954320430tt343
type: Position
type: ExactPosition
position: 343
reference: O67868-1

22296133954320430tt257
type: Position
type: ExactPosition
position: 257
reference: O67868-1

22296133954320430tt262
type: Position
type: ExactPosition
position: 262
reference: O67868-1

22296133954320430tt280
type: Position
type: ExactPosition
position: 280
reference: O67868-1

22296133954320430tt339
type: Position
type: ExactPosition
position: 339
reference: O67868-1

22296133954320430tt341
type: Position
type: ExactPosition
position: 341
reference: O67868-1

2
subclass of: CHEBI_29035

1
subclass of: CHEBI_29035

O67868-1
type: Simple Sequence
modified: 1998-08-01
version: 1
mass: 54543
value: MKEMEVRAFKDDIKKYKGKSVAVFVYEGDLKPLARLSKGTSNKAKRVAELENFKGKEGEILKVPTLGTSVDFVYIVGLGKKEKVGEDTYRRASANLVKRMRRDKVESTVVVIPRRGDVSKEITKAITEGAILGNYRFDKYKSKKEDEKFEIKEVLINRGDEEGIRLGKIFAEAQNYARNLVNEPGNVINPITLAEEAKKLAEEFGLECKVYDEKQIQEMGMMALYSVGKGSATPPRFIHLIYKPSGKPKEKIALVGKGLTFDSGGLNIKPGDYMRTMKMDKSGACAVLGIMRAIAQLKPDVEVHGLIGAAENMPDGNAYRPDDVIKAKNGKYIEIDNTDAEGRVTLADVLSYASELKPDKIIDMATLTGACMVALGEYTAGLFTNAPDFAEEIKKTAKRTGERVWELPMDDERLRKKIKNTVADVLNTGGRYGGAITAAMFLEEFVGEGIKWVHLDIAGPAWSKEEYGYYTKGGTGFGVRTCLEYIMKVSSNV

http://purl.uniprot.org/uniprot/O67868#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/O67868#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/O67868#attribution-DC036A124EC8E88DF072B29F6D9BB9FE
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/O67868#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

C0QSL9
type: Protein
reviewed: true
created: 2009-07-28
modified: 2023-06-28
version: 65
mnemonic: AMPA_PERMH
citation: http://purl.uniprot.org/citations/19136599
recommended name: SIP4C2E197687D5A48E
alternative name: SIP8E066A1821A9A88A
alternative name: SIP2BA06BA51D2DD54D
enzyme: http://purl.uniprot.org/enzyme/3.4.11.1
enzyme: http://purl.uniprot.org/enzyme/3.4.11.10
organism: http://purl.uniprot.org/taxonomy/123214
annotation: SIP58CDAB9CE1E59749
annotation: SIPF2797E365B3D945C
annotation: SIP606685174AE5CFA9
annotation: SIPC0A3A1F9AC939641
annotation: SIPA337ACEB083AEC09
annotation: SIPFC467E1CDD868B3E
annotation: PRO_1000192718
annotation: SIP29078C97ADE1E2CD
annotation: SIP1855499363D1E92B
annotation: SIP91A8304F59790ACE
annotation: SIP9ABB469917469462
annotation: SIPCEB05095DD9BF150
annotation: SIP967866754231630B
annotation: SIPCBF288B0D9A7416A
annotation: SIP4972C2BCC252FF83
annotation: SIPF81843B95699B9F4
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/31
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/464
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005737
classified with: GO_0030145
classified with: GO_0070006
classified with: GO_0006508
sequence: C0QSL9-1
proteome: Chromosome

C0QSL9-citation-19136599
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

DSM 14350 / EX-H1
type: Strain

SIP4C2E197687D5A48E
type: Structured Name
full name: Probable cytosol aminopeptidase
ec name: 3.4.11.1

SIP8E066A1821A9A88A
type: Structured Name
full name: Leucine aminopeptidase
short name: LAP
ec name: 3.4.11.10

SIP2BA06BA51D2DD54D
type: Structured Name
full name: Leucyl aminopeptidase

pepA
type: Gene
locus name: PERMA_1904

SIP58CDAB9CE1E59749
type: Function Annotation
comment: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

SIPC0A3A1F9AC939641
type: Cofactor Annotation
comment: Binds 2 manganese ions per subunit.
cofactor: CHEBI_29035

SIPFC467E1CDD868B3E
type: Similarity Annotation
comment: Belongs to the peptidase M17 family.

PRO_1000192718
type: Chain Annotation
comment: Probable cytosol aminopeptidase
mass: 55379
range: 18911949287602478tt1tt497

18911949287602478tt1
type: Position
type: ExactPosition
position: 1
reference: C0QSL9-1

18911949287602478tt497
type: Position
type: ExactPosition
position: 497
reference: C0QSL9-1

18911949287602478tt276
type: Position
type: ExactPosition
position: 276
reference: C0QSL9-1

18911949287602478tt350
type: Position
type: ExactPosition
position: 350
reference: C0QSL9-1

18911949287602478tt264
type: Position
type: ExactPosition
position: 264
reference: C0QSL9-1

18911949287602478tt269
type: Position
type: ExactPosition
position: 269
reference: C0QSL9-1

18911949287602478tt287
type: Position
type: ExactPosition
position: 287
reference: C0QSL9-1

18911949287602478tt346
type: Position
type: ExactPosition
position: 346
reference: C0QSL9-1

18911949287602478tt348
type: Position
type: ExactPosition
position: 348
reference: C0QSL9-1

2
subclass of: CHEBI_29035

1
subclass of: CHEBI_29035

C0QSL9-1
type: Simple Sequence
modified: 2009-05-05
version: 1
mass: 55379
value: MNIKITSGHLKNARVRAVISFSFKEDRKLSPEIEDLDRILDGAISQLKREQKFDGSDGKILVVPTFGKGKMDYVILIGAGSRRKADLDKVRRLGNISVKTTKKLKIDRFLIDAEPLSVIKEGEDSIAQAVVEGVILGNYRFDKYLSKKDEYRIKELQIRVKRRFKNKAEQSVKVGKILAESQNFTRDIVNEPGNVITPEKLAQIAQDLAREYGFEVKIYDEEEIEKMGMNAYLAVAKGSANPPRFIHIIYRPEKPKKKIALIGKGLTFDSGGLNIKPGDYMRWMKADKSGACAVLGIFKAIGQLKPDVEVHGIIAAAENMPDGRSYRPDDIIKAKNGVTIEIGNTDAEGRLTLADALCYASELKPDAIIDMATLTGACVVALGEYTAGVMGNDERLIDQILDISKRTGEWMWPLPFNDMLREHIKAPHADVYNIGTTRYGGAITAGLFLEKFVDKKIPWVHIDIAGPAHNTKGWYYHPKGATGFPVRTITTFLLNQE

http://purl.uniprot.org/uniprot/C0QSL9#attribution-5B745BD8E303FB1FA1AC6F6C6041F55D
manual: true
evidence: ECO_0000255
source: MF_00181

B2V6F5
type: Protein
reviewed: true
created: 2009-03-24
modified: 2023-06-28
version: 76
mnemonic: AMPA_SULSY
citation: http://purl.uniprot.org/citations/19136599
recommended name: SIP4C2E197687D5A48E
alternative name: SIP8E066A1821A9A88A
alternative name: SIP2BA06BA51D2DD54D
enzyme: http://purl.uniprot.org/enzyme/3.4.11.1
enzyme: http://purl.uniprot.org/enzyme/3.4.11.10
organism: http://purl.uniprot.org/taxonomy/436114
annotation: SIP3750596F30FB59C7
annotation: SIP80082AA3D3E9311F
annotation: SIP7757BA2C28201595
annotation: SIP52A488263E1DB2C1
annotation: SIPC1B6233294B683DF
annotation: SIP504CAF0664330383
annotation: PRO_1000098355
annotation: SIP1D8D7842DEE53920
annotation: SIPD317171DBF7CEF47
annotation: SIP4236F8E57BDC480A
annotation: SIP8A29B38EAE93FC20
annotation: SIP3309E527A5103954
annotation: SIPF43C68224B96BB15
annotation: SIP938A02C254DF8036
annotation: SIP00961F552CF325A7
annotation: SIP6D8550D536230F83
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/31
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/464
classified with: http://purl.uniprot.org/keywords/479
classified with: GO_0005737
classified with: GO_0030145
classified with: GO_0070006
classified with: GO_0006508
sequence: B2V6F5-1

B2V6F5-citation-19136599
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

YO3AOP1
type: Strain

SIP4C2E197687D5A48E
type: Structured Name
full name: Probable cytosol aminopeptidase
ec name: 3.4.11.1

SIP8E066A1821A9A88A
type: Structured Name
full name: Leucine aminopeptidase
short name: LAP
ec name: 3.4.11.10

SIP2BA06BA51D2DD54D
type: Structured Name
full name: Leucyl aminopeptidase

pepA
type: Gene
locus name: SYO3AOP1_0038

SIP3750596F30FB59C7
type: Function Annotation
comment: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

SIP52A488263E1DB2C1
type: Cofactor Annotation
comment: Binds 2 manganese ions per subunit.
cofactor: CHEBI_29035

SIP504CAF0664330383
type: Similarity Annotation
comment: Belongs to the peptidase M17 family.

PRO_1000098355
type: Chain Annotation
comment: Probable cytosol aminopeptidase
mass: 56325
range: 18632694322050350tt1tt504

18632694322050350tt1
type: Position
type: ExactPosition
position: 1
reference: B2V6F5-1

18632694322050350tt504
type: Position
type: ExactPosition
position: 504
reference: B2V6F5-1

18632694322050350tt275
type: Position
type: ExactPosition
position: 275
reference: B2V6F5-1

18632694322050350tt349
type: Position
type: ExactPosition
position: 349
reference: B2V6F5-1

18632694322050350tt263
type: Position
type: ExactPosition
position: 263
reference: B2V6F5-1

18632694322050350tt268
type: Position
type: ExactPosition
position: 268
reference: B2V6F5-1

18632694322050350tt286
type: Position
type: ExactPosition
position: 286
reference: B2V6F5-1

18632694322050350tt345
type: Position
type: ExactPosition
position: 345
reference: B2V6F5-1

18632694322050350tt347
type: Position
type: ExactPosition
position: 347
reference: B2V6F5-1

2
subclass of: CHEBI_29035

1
subclass of: CHEBI_29035

B2V6F5-1
type: Simple Sequence
modified: 2008-07-01
version: 1
mass: 56325
value: MEINLTTKKLDNVKTDAVFFLMFEDNKKLEGELEKIDKALNGGVSDLIKLQKYKAEEGKFLIVPTLGKIKANYVAIVGLGKEKKFENDILRRVASYIIRKAKELKLSDIIIDTNLQQFENYDEVVQAITEGLILGDYSFDKYFSKKDEHKVKEVQVNIPKNQDKDRLNEFVRIGEILAEAQNFTRDLVNEPANVINTIQFAEIAEKLAKEYGFEIKIYDEEEIEKMGMGAYLAVAKGSDNPPRFIHLTYRPKNSQGEVAIVGKGLMFDSGGLNIKTGDFMRWMKSDKSGACAVFGIFKAIGELKPDITVHGIVAAAENMPSGKAYRPDDILKAKNGVTIEVGNTDAEGRLTLADALSYASELKPDAIIDMATLTGACVVALGEFTAGVMGNNQKFINEILKTSEETGEWMWQLPFNDKLREQIKAPHADVYNVGTTRYGGAITAGLFLEKFVDPKIPWVHIDIAGPSHHTSGWYYHPKGATGIPVRTITWYLLKRSKFFDKIGK

http://purl.uniprot.org/uniprot/B2V6F5#attribution-5B745BD8E303FB1FA1AC6F6C6041F55D
manual: true
evidence: ECO_0000255
source: MF_00181

O66515
type: Protein
reviewed: true
created: 2000-05-30
modified: 2023-09-13
version: 124
mnemonic: AMT_AQUAE
citation: http://purl.uniprot.org/citations/9537320
citation: http://purl.uniprot.org/citations/15361618
recommended name: SIPBDEB5A59630654F2
alternative name: SIP6AD3B4946B7EFF6A
alternative name: SIP664D41BF8E8626A5
organism: http://purl.uniprot.org/taxonomy/224324
annotation: SIP547662417AC54497
annotation: SIPD6E4E3E9AE5EECB6
annotation: SIP9E7E9BD94396D005
annotation: SIP7B81D40B0D07BEE2
annotation: SIP3364B77BA6290A7E
annotation: PRO_0000001306
annotation: SIPF41D7DF6D65624ED
annotation: SIPA593FB7436353F3D
annotation: SIP5496F9C49A28AFA4
annotation: SIP0ED8C373F3431A0A
annotation: SIPA60735D2280A727A
annotation: SIP997448D2B0BF9EC3
annotation: SIPC1F1B5B26BA64618
annotation: SIP102CDB3A8D2D288F
annotation: SIP8268CF15AD285D86
annotation: SIPACD6E25EAA15F999
annotation: SIPFDF335ADDB8DA2FB
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/924
classified with: http://purl.uniprot.org/keywords/1003
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/732
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0005886
classified with: GO_0008519
classified with: GO_0072488
sequence: O66515-1
proteome: Chromosome

O66515-citation-9537320
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

VF5
type: Strain

O66515-citation-15361618
type: Citation Statement
scope: PROTEIN SEQUENCE OF N-TERMINUS
scope: CRYSTALLIZATION

1.A.11.1.5
type: Resource
database: TCDB
comment: the ammonium transporter channel (amt) family

COG0004
type: Resource
database: eggNOG
comment: Bacteria

http://purl.uniprot.org/gene3d/1.10.3430.10
type: Resource
database: Gene3D
comment: Ammonium transporter AmtB like domains
signature sequence match: Gene3D 1.10.3430.10 match 1

IPR029020
type: Resource
database: InterPro
comment: Ammonium/urea_transptr

IPR001905
type: Resource
database: InterPro
comment: Ammonium_transpt

IPR018047
type: Resource
database: InterPro
comment: Ammonium_transpt_CS

IPR024041
type: Resource
database: InterPro
comment: NH4_transpt_AmtB-like_dom

TIGR00836
type: Resource
database: NCBIfam
comment: amt
signature sequence match: NCBIfam TIGR00836 match 1

PTHR43029
type: Resource
database: PANTHER
comment: AMMONIUM TRANSPORTER MEP2
signature sequence match: PANTHER PTHR43029 match 1

PTHR43029:SF10
type: Resource
database: PANTHER
comment: AMMONIUM TRANSPORTER MEP2
signature sequence match: PANTHER PTHR43029:SF10 match 1

PF00909
type: Resource
database: Pfam
comment: Ammonium_transp
signature sequence match: Pfam PF00909 match 1

SSF111352
type: Resource
database: SUPFAM
comment: Ammonium transporter
signature sequence match: SUPFAM SSF111352 match 1

PS01219
type: Resource
database: PROSITE
comment: AMMONIUM_TRANSP
signature sequence match: PROSITE PS01219 match 1

SIPBDEB5A59630654F2
type: Structured Name
full name: Ammonium transporter

SIP6AD3B4946B7EFF6A
type: Structured Name
full name: Ammonia channel

SIP664D41BF8E8626A5
type: Structured Name
full name: Ammonium channel

amt
type: Gene
alternative label: amtB
locus name: aq_112

SIP547662417AC54497
type: Function Annotation
comment: Involved in the uptake of ammonium/ammonia (NH(4)(+)/NH(3)).

SIPD6E4E3E9AE5EECB6
type: Subunit Annotation
comment: Homotrimer.

SIP7B81D40B0D07BEE2
type: Similarity Annotation
comment: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.

22296129608693038tt1
type: Position
type: ExactPosition
position: 1
reference: O66515-1

22296129608693038tt20
type: Position
type: ExactPosition
position: 20
reference: O66515-1

PRO_0000001306
type: Chain Annotation
comment: Ammonium transporter
mass: 42163
range: 22296129608693038tt21tt423

22296129608693038tt21
type: Position
type: ExactPosition
position: 21
reference: O66515-1

22296129608693038tt423
type: Position
type: ExactPosition
position: 423
reference: O66515-1

SIPF41D7DF6D65624ED
type: Transmembrane Annotation
comment: Helical
range: 22296129608693038tt31tt51

22296129608693038tt31
type: Position
type: ExactPosition
position: 31
reference: O66515-1

22296129608693038tt51
type: Position
type: ExactPosition
position: 51
reference: O66515-1

SIPA593FB7436353F3D
type: Transmembrane Annotation
comment: Helical
range: 22296129608693038tt64tt84

22296129608693038tt64
type: Position
type: ExactPosition
position: 64
reference: O66515-1

22296129608693038tt84
type: Position
type: ExactPosition
position: 84
reference: O66515-1

SIP5496F9C49A28AFA4
type: Transmembrane Annotation
comment: Helical
range: 22296129608693038tt123tt143

22296129608693038tt123
type: Position
type: ExactPosition
position: 123
reference: O66515-1

22296129608693038tt143
type: Position
type: ExactPosition
position: 143
reference: O66515-1

SIP0ED8C373F3431A0A
type: Transmembrane Annotation
comment: Helical
range: 22296129608693038tt150tt170

22296129608693038tt150
type: Position
type: ExactPosition
position: 150
reference: O66515-1

22296129608693038tt170
type: Position
type: ExactPosition
position: 170
reference: O66515-1

SIPA60735D2280A727A
type: Transmembrane Annotation
comment: Helical
range: 22296129608693038tt183tt203

22296129608693038tt183
type: Position
type: ExactPosition
position: 183
reference: O66515-1

22296129608693038tt203
type: Position
type: ExactPosition
position: 203
reference: O66515-1

SIP997448D2B0BF9EC3
type: Transmembrane Annotation
comment: Helical
range: 22296129608693038tt217tt237

22296129608693038tt217
type: Position
type: ExactPosition
position: 217
reference: O66515-1

22296129608693038tt237
type: Position
type: ExactPosition
position: 237
reference: O66515-1

SIPC1F1B5B26BA64618
type: Transmembrane Annotation
comment: Helical
range: 22296129608693038tt246tt266

22296129608693038tt246
type: Position
type: ExactPosition
position: 246
reference: O66515-1

22296129608693038tt266
type: Position
type: ExactPosition
position: 266
reference: O66515-1

SIP102CDB3A8D2D288F
type: Transmembrane Annotation
comment: Helical
range: 22296129608693038tt278tt298

22296129608693038tt278
type: Position
type: ExactPosition
position: 278
reference: O66515-1

22296129608693038tt298
type: Position
type: ExactPosition
position: 298
reference: O66515-1

SIP8268CF15AD285D86
type: Transmembrane Annotation
comment: Helical
range: 22296129608693038tt301tt321

22296129608693038tt301
type: Position
type: ExactPosition
position: 301
reference: O66515-1

22296129608693038tt321
type: Position
type: ExactPosition
position: 321
reference: O66515-1

SIPACD6E25EAA15F999
type: Transmembrane Annotation
comment: Helical
range: 22296129608693038tt331tt351

22296129608693038tt331
type: Position
type: ExactPosition
position: 331
reference: O66515-1

22296129608693038tt351
type: Position
type: ExactPosition
position: 351
reference: O66515-1

SIPFDF335ADDB8DA2FB
type: Transmembrane Annotation
comment: Helical
range: 22296129608693038tt374tt394

22296129608693038tt374
type: Position
type: ExactPosition
position: 374
reference: O66515-1

22296129608693038tt394
type: Position
type: ExactPosition
position: 394
reference: O66515-1

O66515-1
type: Simple Sequence
modified: 1998-08-01
version: 1
precursor: true
mass: 44323
value: MRALGFIGIILSIFSSFAYASEAKLDTGNTAWMLVASALVVFMTVPGLALFYGGLDKSKSILNTIAMSFSAFAVVTLTWIFVGYSVAYGDDIFGFIGNPFQYVLGKGISGINSDTGYPALLDLMFQLTFATITTALISGSFVGRMKFSAWILFAILWSVFVYPPVAHWVWGGGFLANDGALDFAGGTVVHINAGIAGLVGALILGRRKDTSLIPNNVPLVALGAGILWFGWFGFNAGSALGANESAAWAMINTTVATSTAALAWMFTEWLHVGKPTVVGISSGIVAGLVAITPAAGFVNLIGSIFIGAIASVCAYFMVALVKPKFGYDDALDVFGIHGVRGIVGAVLTGVFADPNVGGTPGLLYGNPKQVLIQIEGVIATILYSAILTAVILLVLKAVVGLRVSEEEELELDSSLHGEKAYNL

http://purl.uniprot.org/uniprot/O66515#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/O66515#attribution-FBB36F9CC59C1401A241B180D4B1D8CA
manual: true
evidence: ECO_0000250
source: P69681

http://purl.uniprot.org/uniprot/O66515#attribution-DC036A124EC8E88DF072B29F6D9BB9FE
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/O66515#attribution-97875B81A03D878DC672CD4A2CA49179
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/15361618

http://purl.uniprot.org/uniprot/O66515#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

O66946
type: Protein
reviewed: true
created: 2000-05-30
modified: 2023-06-28
version: 130
mnemonic: APBC_AQUAE
old mnemonic: MRP_AQUAE
citation: http://purl.uniprot.org/citations/9537320
recommended name: SIPFC52D4B1539357D6
organism: http://purl.uniprot.org/taxonomy/224324
annotation: SIP1DEB02138A4F2EC8
annotation: SIP2502A31A5A5A7FB3
annotation: SIPFEB5B32F879246A6
annotation: PRO_0000184928
annotation: SIP76CC61E3650F1742
annotation: SIP4F395F622F26CC50
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/378
classified with: http://purl.uniprot.org/keywords/411
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0051539
classified with: GO_0005524
classified with: GO_0016887
classified with: GO_0140663
classified with: GO_0046872
classified with: GO_0016226
sequence: O66946-1
proteome: Chromosome

O66946-citation-9537320
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

VF5
type: Strain

COG0489
type: Resource
database: eggNOG
comment: Bacteria

cd02037
type: Resource
database: CDD
comment: Mrp_NBP35
signature sequence match: CDD cd02037 match 1

http://purl.uniprot.org/gene3d/3.40.50.300
type: Resource
database: Gene3D
comment: P-loop containing nucleotide triphosphate hydrolases
signature sequence match: Gene3D 3.40.50.300 match 1
signature sequence match: Gene3D 3.40.50.300 match 2
signature sequence match: Gene3D 3.40.50.300 match 3

MF_02040
type: Resource
database: HAMAP
comment: Mrp_NBP35
signature sequence match: HAMAP MF 02040 match 1

IPR019591
type: Resource
database: InterPro
comment: Mrp/NBP35_ATP-bd

IPR000808
type: Resource
database: InterPro
comment: Mrp_CS

IPR044304
type: Resource
database: InterPro
comment: NUBPL-like

IPR027417
type: Resource
database: InterPro
comment: P-loop_NTPase

IPR033756
type: Resource
database: InterPro
comment: YlxH/NBP35

PTHR42961
type: Resource
database: PANTHER
comment: IRON-SULFUR PROTEIN NUBPL
signature sequence match: PANTHER PTHR42961 match 1

PTHR42961:SF2
type: Resource
database: PANTHER
comment: IRON-SULFUR PROTEIN NUBPL
signature sequence match: PANTHER PTHR42961:SF2 match 1

PF10609
type: Resource
database: Pfam
comment: ParA
signature sequence match: Pfam PF10609 match 1

SSF52540
type: Resource
database: SUPFAM
comment: P-loop containing nucleoside triphosphate hydrolases
signature sequence match: SUPFAM SSF52540 match 1
signature sequence match: SUPFAM SSF52540 match 2

PS01215
type: Resource
database: PROSITE
comment: MRP
signature sequence match: PROSITE PS01215 match 1

SIPFC52D4B1539357D6
type: Structured Name
full name: Iron-sulfur cluster carrier protein

mrp
type: Gene
locus name: aq_737

SIP1DEB02138A4F2EC8
type: Function Annotation
comment: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.

SIP2502A31A5A5A7FB3
type: Subunit Annotation
comment: Homodimer.

SIPFEB5B32F879246A6
type: Similarity Annotation
comment: Belongs to the Mrp/NBP35 ATP-binding proteins family.

PRO_0000184928
type: Chain Annotation
comment: Iron-sulfur cluster carrier protein
mass: 39492
range: 22296129675998766tt1tt364

22296129675998766tt1
type: Position
type: ExactPosition
position: 1
reference: O66946-1

22296129675998766tt364
type: Position
type: ExactPosition
position: 364
reference: O66946-1

SIP76CC61E3650F1742
type: Region Annotation
comment: Disordered
range: 22296129675998766tt83tt102

22296129675998766tt83
type: Position
type: ExactPosition
position: 83
reference: O66946-1

22296129675998766tt102
type: Position
type: ExactPosition
position: 102
reference: O66946-1

22296129675998766tt120
type: Position
type: ExactPosition
position: 120
reference: O66946-1

22296129675998766tt127
type: Position
type: ExactPosition
position: 127
reference: O66946-1

O66946-1
type: Simple Sequence
modified: 1998-08-01
version: 1
mass: 39492
value: MAVQDVIEALKKETLEDVGINQNLAQLVKDIKMVGNVLTIVFEPPKQGLEDIIRAKVIDALGNLPEVQKIDVKFVKPQAQIPVKQQAPQQQQTPPPQTQQPMFTRKKVPGVKHIIAVGSGKGGVGKSTVAANLAVALSQLGYKVGLLDADVYGPSVPTLFGLKGERVTVDQFQRIIPVEKYGLKILSIGFMLPSEDTPIIWRGPMLMKALTEFLFSTKWGNLDFLVMDLPPGTGDVQITLAQNVELTGAVVVTTPQDVALADVKKAVSMFREVNIPVLGVIENMAYFICPSDKQKYYIFGKGKVAEFANAYGLKILGSIPIDPEVAEKSDKGEPIVISHPDSEVAKAFLSIAKVLSQVVESKVN

http://purl.uniprot.org/uniprot/O66946#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/O66946#attribution-A7048BFDF96838328BD9408666D1DBE6
manual: true
evidence: ECO_0000255
source: MF_02040

O66820
type: Protein
reviewed: true
created: 2002-05-02
modified: 2023-09-13
version: 126
mnemonic: APGM_AQUAE
citation: http://purl.uniprot.org/citations/9537320
recommended name: SIP1F26AFD2D3960784
enzyme: http://purl.uniprot.org/enzyme/5.4.2.12
organism: http://purl.uniprot.org/taxonomy/224324
annotation: SIP4680162424DC8659
annotation: SIP009C81A6467BC58E
annotation: SIP5D73434CCD7F5833
annotation: SIP7CD8F705131A4F44
annotation: PRO_0000138152
annotation: SIP914AC28EC2F9F3D0
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/324
classified with: http://purl.uniprot.org/keywords/413
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0046537
classified with: GO_0046872
classified with: GO_0006096
sequence: O66820-1
proteome: Chromosome

O66820-citation-9537320
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

VF5
type: Strain

COG3635
type: Resource
database: eggNOG
comment: Bacteria

cd16011
type: Resource
database: CDD
comment: iPGM_like
signature sequence match: CDD cd16011 match 1

http://purl.uniprot.org/gene3d/3.40.720.10
type: Resource
database: Gene3D
comment: Alkaline Phosphatase, subunit A
signature sequence match: Gene3D 3.40.720.10 match 1
signature sequence match: Gene3D 3.40.720.10 match 2

MF 01402 B
type: Resource
database: HAMAP
comment: ApgM_B
signature sequence match: HAMAP MF 01402 B match 1

IPR017850
type: Resource
database: InterPro
comment: Alkaline_phosphatase_core_sf

IPR023665
type: Resource
database: InterPro
comment: ApgAM_prokaryotes

IPR006124
type: Resource
database: InterPro
comment: Metalloenzyme

IPR004456
type: Resource
database: InterPro
comment: Pglycerate_mutase_ApgM

TIGR00306
type: Resource
database: NCBIfam
comment: apgM
signature sequence match: NCBIfam TIGR00306 match 1

PTHR31209
type: Resource
database: PANTHER
comment: COFACTOR-INDEPENDENT PHOSPHOGLYCERATE MUTASE
signature sequence match: PANTHER PTHR31209 match 1

PTHR31209:SF0
type: Resource
database: PANTHER
comment: METALLOENZYME DOMAIN-CONTAINING PROTEIN
signature sequence match: PANTHER PTHR31209:SF0 match 1

PF01676
type: Resource
database: Pfam
comment: Metalloenzyme
signature sequence match: Pfam PF01676 match 1

PF10143
type: Resource
database: Pfam
comment: PhosphMutase
signature sequence match: Pfam PF10143 match 1

PIRSF006392
type: Resource
database: PIRSF
comment: IPGAM_arch
signature sequence match: PIRSF PIRSF006392 match 1

SSF53649
type: Resource
database: SUPFAM
comment: Alkaline phosphatase-like
signature sequence match: SUPFAM SSF53649 match 1

SIP1F26AFD2D3960784
type: Structured Name
full name: Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
short name: BPG-independent PGAM
short name: Phosphoglyceromutase
short name: aPGAM
ec name: 5.4.2.12

apgM
type: Gene
locus name: aq_542

SIP4680162424DC8659
type: Function Annotation
comment: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

SIP7CD8F705131A4F44
type: Similarity Annotation
comment: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.

PRO_0000138152
type: Chain Annotation
comment: Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
mass: 45006
range: 22296129659088942tt1tt407

22296129659088942tt1
type: Position
type: ExactPosition
position: 1
reference: O66820-1

22296129659088942tt407
type: Position
type: ExactPosition
position: 407
reference: O66820-1

SIP914AC28EC2F9F3D0
type: Region Annotation
comment: Disordered
range: 22296129659088942tt175tt200

22296129659088942tt175
type: Position
type: ExactPosition
position: 175
reference: O66820-1

22296129659088942tt200
type: Position
type: ExactPosition
position: 200
reference: O66820-1

O66820-1
type: Simple Sequence
modified: 1998-08-01
version: 1
mass: 45006
value: MDVISELVKKNGSKILLIVLDGLGGLPVKEGKTELELAKTPNLDKLVKNSATGLHIPVDWGITPGSGPGHLGLFGYDPIKYQIGRGILEALGLGIDVKDTDIAVRGNYATVEYRNGKPIVVDRRAGRIPTEENKRITAKLQEAIKEIDGVQVIIKPGMEHRLAIVFRFPEKLSPGSDAINDTDPQQVGKEPLEPKGENPNAEKVAEVVRKFIQRATEILRNEPKANYILLRGFSQKPDIPTMEERFGVKPCCIAVYPMYKGLASLVGMDVIEFEGSTIQDEIDTLKKVWNEYDYFFVHIKKTDSYGEDGNYEGKVSVIEDFDAHLPQFLELKPDVLAITGDHSTPSILKGHSWHPVPLLIHSPYVLGGTSERFTERECLKGELGIIPAVKITQLLLANALRLKKYGA

http://purl.uniprot.org/uniprot/O66820#attribution-177E28A52F98AEF8E1D764E5698AF3EF
manual: true
evidence: ECO_0000255
source: MF_01402

O67848
type: Protein
reviewed: true
created: 2000-05-30
modified: 2023-09-13
version: 138
mnemonic: ARGB_AQUAE
citation: http://purl.uniprot.org/citations/9537320
conflicting sequence: SIPBCBB131D35CA4383
recommended name: SIP50B31DE58A55D716
alternative name: SIP42AA6A17FF2F6FE5
alternative name: SIPFC488A42BB3877A9
enzyme: http://purl.uniprot.org/enzyme/2.7.2.8
organism: http://purl.uniprot.org/taxonomy/224324
annotation: SIPD5FBA0D06D986451
annotation: SIP17B5BD90EC335961
annotation: SIP9C4015671EB30607
annotation: SIP8E80B8931994B936
annotation: SIPF8D152BDEA7007F2
annotation: SIPE0EDCCC41CD56E7B
annotation: PRO_0000112575
annotation: SIP79F611ACAD1E3B3A
annotation: SIP0805E337E7DCD408
annotation: SIP53DA969C5A6E0AE8
annotation: SIPB1C39D70BEAAB930
annotation: SIPBAA652725CB1F562
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/55
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/418
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005737
classified with: GO_0003991
classified with: GO_0005524
classified with: GO_0006526
classified with: GO_0042450
classified with: GO_0016310
sequence: O67848-1
proteome: Chromosome

O67848-citation-9537320
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

VF5
type: Strain

EMBL AAC07812.1
comment: Frameshift.

COG0548
type: Resource
database: eggNOG
comment: Bacteria

http://purl.uniprot.org/brenda/3.5.1.108
type: Resource
database: BRENDA
comment: 396

cd04250
type: Resource
database: CDD
comment: AAK_NAGK-C
signature sequence match: CDD cd04250 match 1

MF_00082
type: Resource
database: HAMAP
comment: ArgB
signature sequence match: HAMAP MF 00082 match 1

IPR004662
type: Resource
database: InterPro
comment: AcgluKinase_fam

IPR037528
type: Resource
database: InterPro
comment: ArgB

IPR001057
type: Resource
database: InterPro
comment: Glu/AcGlu_kinase

IPR041727
type: Resource
database: InterPro
comment: NAGK-C

TIGR00761
type: Resource
database: NCBIfam
comment: argB
signature sequence match: NCBIfam TIGR00761 match 1

PTHR23342
type: Resource
database: PANTHER
comment: N-ACETYLGLUTAMATE SYNTHASE
signature sequence match: PANTHER PTHR23342 match 1

PTHR23342:SF0
type: Resource
database: PANTHER
comment: N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL
signature sequence match: PANTHER PTHR23342:SF0 match 1

PIRSF000728
type: Resource
database: PIRSF
comment: NAGK
signature sequence match: PIRSF PIRSF000728 match 1

PR00474
type: Resource
database: PRINTS
comment: GLU5KINASE

SIP50B31DE58A55D716
type: Structured Name
full name: Acetylglutamate kinase
ec name: 2.7.2.8

SIP42AA6A17FF2F6FE5
type: Structured Name
full name: N-acetyl-L-glutamate 5-phosphotransferase

SIPFC488A42BB3877A9
type: Structured Name
full name: NAG kinase
short name: NAGK

argB
type: Gene
locus name: aq_2068

SIPD5FBA0D06D986451
type: Function Annotation
comment: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.

SIPF8D152BDEA7007F2
type: Similarity Annotation
comment: Belongs to the acetylglutamate kinase family. ArgB subfamily.

PRO_0000112575
type: Chain Annotation
comment: Acetylglutamate kinase
mass: 32908
range: 22296133954189358tt1tt298

22296133954189358tt1
type: Position
type: ExactPosition
position: 1
reference: O67848-1

22296133954189358tt298
type: Position
type: ExactPosition
position: 298
reference: O67848-1

22296133954189358tt64
type: Position
type: ExactPosition
position: 64
reference: O67848-1

22296133954189358tt65
type: Position
type: ExactPosition
position: 65
reference: O67848-1

22296133954189358tt86
type: Position
type: ExactPosition
position: 86
reference: O67848-1

22296133954189358tt195
type: Position
type: ExactPosition
position: 195
reference: O67848-1

SIPB1C39D70BEAAB930
type: Site Annotation
comment: Transition state stabilizer
range: 22296133954189358tt29tt29

22296133954189358tt29
type: Position
type: ExactPosition
position: 29
reference: O67848-1

SIPBAA652725CB1F562
type: Site Annotation
comment: Transition state stabilizer
range: 22296133954189358tt255tt255

22296133954189358tt255
type: Position
type: ExactPosition
position: 255
reference: O67848-1

substrate

O67848-1
type: Simple Sequence
modified: 2000-05-30
version: 2
mass: 32908
value: MNELIEKAKVLQEALPYIREFHGKVFVIKYGGSAMHDEELRESFARDVVLLKYVGINPVIVHGGGPQISKTLEKFGIKPKFVGGMRKTDEETMHVVEMVLSGDINKDIVALINRYSGEKIYAVGLSGRDGRLLKAKKLDKERYFSELGLPVPEEDIGFVGEIVDVNEELIFTLLSHNFIPVIAPVGVGEEGEAYNVNADLAASEIAGEIKAEKLIYLTDTKGVLDEKGELISSLSKDKAEELIKKGVIREGMIPKVRSALRALEKGVKKVHIIDGRVKHSILLEVFTKEGVGTEITLE

http://purl.uniprot.org/uniprot/O67848#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/O67848#attribution-89C4AE5EE4E7552140FBE18DBB8442F5
manual: true
evidence: ECO_0000255
source: MF_00082

http://purl.uniprot.org/uniprot/O67848#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

B4U7A6
type: Protein
reviewed: true
created: 2009-03-24
modified: 2023-09-13
version: 79
mnemonic: ARGB_HYDS0
citation: http://purl.uniprot.org/citations/19136599
recommended name: SIP50B31DE58A55D716
alternative name: SIP42AA6A17FF2F6FE5
alternative name: SIPFC488A42BB3877A9
enzyme: http://purl.uniprot.org/enzyme/2.7.2.8
organism: http://purl.uniprot.org/taxonomy/380749
annotation: SIP8880229C69F8516B
annotation: SIP6910D15FABE05337
annotation: SIPBCFE64B453165DB6
annotation: SIP7D7BD2CFACA41FBA
annotation: SIP9236E43F6E4FEDB9
annotation: PRO_1000092862
annotation: SIP2832C1FBCDF5D54F
annotation: SIP9D55C494D746D6EC
annotation: SIP3E90AD7918566423
annotation: SIP11FA5182211F3B34
annotation: SIP05C54C3004869499
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/55
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/418
classified with: GO_0005737
classified with: GO_0003991
classified with: GO_0005524
classified with: GO_0042450
classified with: GO_0016310
sequence: B4U7A6-1

B4U7A6-citation-19136599
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

Y04AAS1
type: Strain

SIP50B31DE58A55D716
type: Structured Name
full name: Acetylglutamate kinase
ec name: 2.7.2.8

SIP42AA6A17FF2F6FE5
type: Structured Name
full name: N-acetyl-L-glutamate 5-phosphotransferase

SIPFC488A42BB3877A9
type: Structured Name
full name: NAG kinase
short name: NAGK

argB
type: Gene
locus name: HY04AAS1_0327

SIP8880229C69F8516B
type: Function Annotation
comment: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.

SIP9236E43F6E4FEDB9
type: Similarity Annotation
comment: Belongs to the acetylglutamate kinase family. ArgB subfamily.

PRO_1000092862
type: Chain Annotation
comment: Acetylglutamate kinase
mass: 31769
range: 18634889066788398tt1tt287

18634889066788398tt1
type: Position
type: ExactPosition
position: 1
reference: B4U7A6-1

18634889066788398tt287
type: Position
type: ExactPosition
position: 287
reference: B4U7A6-1

18634889066788398tt64
type: Position
type: ExactPosition
position: 64
reference: B4U7A6-1

18634889066788398tt65
type: Position
type: ExactPosition
position: 65
reference: B4U7A6-1

18634889066788398tt86
type: Position
type: ExactPosition
position: 86
reference: B4U7A6-1

18634889066788398tt185
type: Position
type: ExactPosition
position: 185
reference: B4U7A6-1

SIP11FA5182211F3B34
type: Site Annotation
comment: Transition state stabilizer
range: 18634889066788398tt29tt29

18634889066788398tt29
type: Position
type: ExactPosition
position: 29
reference: B4U7A6-1

SIP05C54C3004869499
type: Site Annotation
comment: Transition state stabilizer
range: 18634889066788398tt245tt245

18634889066788398tt245
type: Position
type: ExactPosition
position: 245
reference: B4U7A6-1

substrate

B4U7A6-1
type: Simple Sequence
modified: 2008-09-23
version: 1
mass: 31769
value: MEQLLEKALILQEALPFIRDFYGKVFVVKYGGAAMEEEELKHSFAKDIALLRYVGIKVVLVHGGGKDITNMLNKLNIQTEFINGIRKTDKESLDVARMVLIGKLNKDIVSMLNKEMSNMHGAIGLSGIDANLLICTKYYQDGEDIGYVGKVKTVNTKLIRELIQMDYTPVIAPIGIDPESNQMYNVNADMAATEIACELGAEKLIFLTDTDGILDKSGKTISSIHKNQYKELIEDGTITKGMIPKINSAIDAILRGVRKVHIINGKIKHSILIEVFTKEGIGTEISL

http://purl.uniprot.org/uniprot/B4U7A6#attribution-89C4AE5EE4E7552140FBE18DBB8442F5
manual: true
evidence: ECO_0000255
source: MF_00082

C0QRI8
type: Protein
reviewed: true
created: 2009-07-28
modified: 2023-09-13
version: 71
mnemonic: ARGB_PERMH
citation: http://purl.uniprot.org/citations/19136599
recommended name: SIP50B31DE58A55D716
alternative name: SIP42AA6A17FF2F6FE5
alternative name: SIPFC488A42BB3877A9
enzyme: http://purl.uniprot.org/enzyme/2.7.2.8
organism: http://purl.uniprot.org/taxonomy/123214
annotation: SIPCDD43D15A90205E5
annotation: SIP087A12303109349D
annotation: SIPE8D1BCF8CEF6BF48
annotation: SIP320089D1C09FD268
annotation: SIP384EEE51D5290D66
annotation: PRO_1000118359
annotation: SIP23540065D9F7965B
annotation: SIP051A28FAB9D6147F
annotation: SIP380D3E5BCD9A511F
annotation: SIP49585D4B05299C5F
annotation: SIPC7364807A1EB3407
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/55
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/418
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005737
classified with: GO_0003991
classified with: GO_0005524
classified with: GO_0042450
classified with: GO_0016310
sequence: C0QRI8-1
proteome: Chromosome

C0QRI8-citation-19136599
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

DSM 14350 / EX-H1
type: Strain

SIP50B31DE58A55D716
type: Structured Name
full name: Acetylglutamate kinase
ec name: 2.7.2.8

SIP42AA6A17FF2F6FE5
type: Structured Name
full name: N-acetyl-L-glutamate 5-phosphotransferase

SIPFC488A42BB3877A9
type: Structured Name
full name: NAG kinase
short name: NAGK

argB
type: Gene
locus name: PERMA_1517

SIPCDD43D15A90205E5
type: Function Annotation
comment: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.

SIP384EEE51D5290D66
type: Similarity Annotation
comment: Belongs to the acetylglutamate kinase family. ArgB subfamily.

PRO_1000118359
type: Chain Annotation
comment: Acetylglutamate kinase
mass: 32668
range: 18911949270628398tt1tt299

18911949270628398tt1
type: Position
type: ExactPosition
position: 1
reference: C0QRI8-1

18911949270628398tt299
type: Position
type: ExactPosition
position: 299
reference: C0QRI8-1

18911949270628398tt64
type: Position
type: ExactPosition
position: 64
reference: C0QRI8-1

18911949270628398tt65
type: Position
type: ExactPosition
position: 65
reference: C0QRI8-1

18911949270628398tt86
type: Position
type: ExactPosition
position: 86
reference: C0QRI8-1

18911949270628398tt197
type: Position
type: ExactPosition
position: 197
reference: C0QRI8-1

SIP49585D4B05299C5F
type: Site Annotation
comment: Transition state stabilizer
range: 18911949270628398tt29tt29

18911949270628398tt29
type: Position
type: ExactPosition
position: 29
reference: C0QRI8-1

SIPC7364807A1EB3407
type: Site Annotation
comment: Transition state stabilizer
range: 18911949270628398tt257tt257

18911949270628398tt257
type: Position
type: ExactPosition
position: 257
reference: C0QRI8-1

substrate

C0QRI8-1
type: Simple Sequence
modified: 2009-05-05
version: 1
mass: 32668
value: MERLVEKAEILMEALPFITKFRGKTFVIKYGGNAMAKADLKVAFAQDILMLKYIGINPVIVHGGGPQIGQMLKRMGLESKFVGGLRVTDRETMEVVEMVLGGLVNKSIVMLINRYAGGHIRAVGLTGKDGGLIRAKKLDAQEYFRQMGDFRPTELLDLGHVGEVEYIDTQILKHLEEDNYIPVIAPVGFDTEGNAYNINADFVASAVAGALKAEKVIFLTDIEGLKDEQGNTVSSINVERINRMIEEGVIKGGMIPKVKACIQALSQGVKKAHILDGRIPHCVLLEIFTSEGIGTEIVS

http://purl.uniprot.org/uniprot/C0QRI8#attribution-89C4AE5EE4E7552140FBE18DBB8442F5
manual: true
evidence: ECO_0000255
source: MF_00082

B2V7Y5
type: Protein
reviewed: true
created: 2009-04-14
modified: 2023-09-13
version: 88
mnemonic: ARGB_SULSY
citation: http://purl.uniprot.org/citations/19136599
recommended name: SIP50B31DE58A55D716
alternative name: SIP42AA6A17FF2F6FE5
alternative name: SIPFC488A42BB3877A9
enzyme: http://purl.uniprot.org/enzyme/2.7.2.8
organism: http://purl.uniprot.org/taxonomy/436114
annotation: SIP1A0AD5FCF9E1378F
annotation: SIPB41FF53563412C5B
annotation: SIP2A14995EA9B9E77B
annotation: SIP2650FBA8124B0B85
annotation: SIPBC5BA15A363D35FF
annotation: PRO_1000117131
annotation: SIPCCBC2D1C0A33CC10
annotation: SIPDB4E1EA22724606B
annotation: SIP89AACE61C1E5AEDF
annotation: SIPF50CDE2C24946872
annotation: SIP13405682D62D15DB
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/55
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/418
classified with: GO_0005737
classified with: GO_0003991
classified with: GO_0005524
classified with: GO_0042450
classified with: GO_0016310
sequence: B2V7Y5-1

B2V7Y5-citation-19136599
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

YO3AOP1
type: Strain

SIP50B31DE58A55D716
type: Structured Name
full name: Acetylglutamate kinase
ec name: 2.7.2.8

SIP42AA6A17FF2F6FE5
type: Structured Name
full name: N-acetyl-L-glutamate 5-phosphotransferase

SIPFC488A42BB3877A9
type: Structured Name
full name: NAG kinase
short name: NAGK

argB
type: Gene
locus name: SYO3AOP1_0415

SIP1A0AD5FCF9E1378F
type: Function Annotation
comment: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.

SIPBC5BA15A363D35FF
type: Similarity Annotation
comment: Belongs to the acetylglutamate kinase family. ArgB subfamily.

PRO_1000117131
type: Chain Annotation
comment: Acetylglutamate kinase
mass: 32407
range: 18632694340072750tt1tt299

18632694340072750tt1
type: Position
type: ExactPosition
position: 1
reference: B2V7Y5-1

18632694340072750tt299
type: Position
type: ExactPosition
position: 299
reference: B2V7Y5-1

18632694340072750tt64
type: Position
type: ExactPosition
position: 64
reference: B2V7Y5-1

18632694340072750tt65
type: Position
type: ExactPosition
position: 65
reference: B2V7Y5-1

18632694340072750tt86
type: Position
type: ExactPosition
position: 86
reference: B2V7Y5-1

18632694340072750tt197
type: Position
type: ExactPosition
position: 197
reference: B2V7Y5-1

SIPF50CDE2C24946872
type: Site Annotation
comment: Transition state stabilizer
range: 18632694340072750tt29tt29

18632694340072750tt29
type: Position
type: ExactPosition
position: 29
reference: B2V7Y5-1

SIP13405682D62D15DB
type: Site Annotation
comment: Transition state stabilizer
range: 18632694340072750tt257tt257

18632694340072750tt257
type: Position
type: ExactPosition
position: 257
reference: B2V7Y5-1

substrate

B2V7Y5-1
type: Simple Sequence
modified: 2008-07-01
version: 1
mass: 32407
value: MESIIEKAEILLEALPFIRNFRGKTFVIKYGGNAMDKADLRDAFAQDIIMLKYIGINPVIVHGGGPQIGQYLKKMGLESKFVGGLRVTDKETMDIVEMVLGGLVNKSIVQLINSYSGGHVKAVGITGKDGCLIKAKKLDAEEYFRSIGDYRPTELLDLGHVGEVEEVNPELLIHLDEDNYIPVIAPIGFDAEGNAYNINADFVAAAIAGALKAEKVLFLTDIEGLKDENGNTLSSATVSQINQMIKDGVIKGGMIPKVKACIQALEKGVNKAHILDGRLPHCILLEIFTKKGVGTEITL

http://purl.uniprot.org/uniprot/B2V7Y5#attribution-89C4AE5EE4E7552140FBE18DBB8442F5
manual: true
evidence: ECO_0000255
source: MF_00082

O67724
type: Protein
reviewed: true
created: 2000-12-01
modified: 2023-09-13
version: 132
mnemonic: ARGC_AQUAE
citation: http://purl.uniprot.org/citations/9537320
recommended name: SIP21AA9D787FDBB406
alternative name: SIP59D6176D9B5E4DB4
enzyme: http://purl.uniprot.org/enzyme/1.2.1.38
organism: http://purl.uniprot.org/taxonomy/224324
annotation: SIPE228EB10A5353254
annotation: SIPCEE373AC92F9FBC5
annotation: SIP942733E1A4711FD3
annotation: SIP2A7DED4C2A7F3F15
annotation: SIPDE1D38D91151574D
annotation: PRO_0000112375
annotation: SIP3712FF4309289B08
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/55
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/521
classified with: http://purl.uniprot.org/keywords/560
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005737
classified with: GO_0003942
classified with: GO_0051287
classified with: GO_0070401
classified with: GO_0046983
classified with: GO_0006526
sequence: O67724-1
proteome: Chromosome

O67724-citation-9537320
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

VF5
type: Strain

COG0002
type: Resource
database: eggNOG
comment: Bacteria

http://purl.uniprot.org/gene3d/3.40.50.720
type: Resource
database: Gene3D
comment: NAD(P)-binding Rossmann-like Domain
signature sequence match: Gene3D 3.40.50.720 match 1

MF_00150
type: Resource
database: HAMAP
comment: ArgC_type1
signature sequence match: HAMAP MF 00150 match 1

IPR023013
type: Resource
database: InterPro
comment: AGPR_AS

IPR000706
type: Resource
database: InterPro
comment: AGPR_type-1

IPR036291
type: Resource
database: InterPro
comment: NAD(P)-bd_dom_sf

IPR000534
type: Resource
database: InterPro
comment: Semialdehyde_DH_NAD-bd

IPR012280
type: Resource
database: InterPro
comment: Semialdhyde_DH_dimer_dom

TIGR01850
type: Resource
database: NCBIfam
comment: argC
signature sequence match: NCBIfam TIGR01850 match 1

PTHR32338:SF10
type: Resource
database: PANTHER
comment: N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE REDUCTASE, CHLOROPLASTIC-RELATED
signature sequence match: PANTHER PTHR32338:SF10 match 1

PTHR32338
type: Resource
database: PANTHER
comment: N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE REDUCTASE, CHLOROPLASTIC-RELATED-RELATED
signature sequence match: PANTHER PTHR32338 match 1

PF01118
type: Resource
database: Pfam
comment: Semialdhyde_dh
signature sequence match: Pfam PF01118 match 1

PF02774
type: Resource
database: Pfam
comment: Semialdhyde_dhC
signature sequence match: Pfam PF02774 match 1

SM00859
type: Resource
database: SMART
comment: Semialdhyde_dh
signature sequence match: SMART SM00859 match 1

SSF55347
type: Resource
database: SUPFAM
comment: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
signature sequence match: SUPFAM SSF55347 match 1

SSF51735
type: Resource
database: SUPFAM
comment: NAD(P)-binding Rossmann-fold domains
signature sequence match: SUPFAM SSF51735 match 1

PS01224
type: Resource
database: PROSITE
comment: ARGC
signature sequence match: PROSITE PS01224 match 1

SIP21AA9D787FDBB406
type: Structured Name
full name: N-acetyl-gamma-glutamyl-phosphate reductase
short name: AGPR
ec name: 1.2.1.38

SIP59D6176D9B5E4DB4
type: Structured Name
full name: N-acetyl-glutamate semialdehyde dehydrogenase
short name: NAGSA dehydrogenase

argC
type: Gene
locus name: aq_1879

SIPE228EB10A5353254
type: Function Annotation
comment: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.

SIPDE1D38D91151574D
type: Similarity Annotation
comment: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

PRO_0000112375
type: Chain Annotation
comment: N-acetyl-gamma-glutamyl-phosphate reductase
mass: 38958
range: 22296133937280046tt1tt340

22296133937280046tt1
type: Position
type: ExactPosition
position: 1
reference: O67724-1

22296133937280046tt340
type: Position
type: ExactPosition
position: 340
reference: O67724-1

22296133937280046tt151
type: Position
type: ExactPosition
position: 151
reference: O67724-1

O67724-1
type: Simple Sequence
modified: 1998-08-01
version: 1
mass: 38958
value: MEQTLRVSVFGATGYTGIELLRSLLTHPHFEVKNLISQSYKGKKVREVLPFFSNTYISEIEFLEEPVEDYELAFLCLPHEVSYEIVPKLLSQGKKVVDLSGAYRIKSPKAYEEFYGFKHEREDILQRAVYGLPEVFREEIKNSDLVANPGCYPTATLLAIYPFLKERVGIESVIVHALSGVSGAGRKPKQQFHFPEMTENFFNYAVEKHRHTPEMEDVIRRVYGREVKVRFTPTVVPTSRGMISTVYLKSEKLNVKELFKEVYEDEIFVKVVDEPPQTKWVLGTNYCFIYPHYDERTGYYVIISAIDNLGKGASLQAVQNANLMFGLAEDDGLLQLPVFP

http://purl.uniprot.org/uniprot/O67724#attribution-43D39B81B54D13C15DBBCB68A6E81D52
manual: true
evidence: ECO_0000255
source: MF_00150

O66442
type: Protein
reviewed: true
created: 2000-05-30
modified: 2023-09-13
version: 151
mnemonic: ARGD_AQUAE
citation: http://purl.uniprot.org/citations/9537320
citation: SIPF7E93D309AD4AD8
recommended name: SIPBA190430D12FCA08
enzyme: http://purl.uniprot.org/enzyme/2.6.1.11
organism: http://purl.uniprot.org/taxonomy/224324
annotation: SIP872704DC8AE5D23A
annotation: SIPAD25EA273272B13C
annotation: SIP2E48B2EB9A455178
annotation: SIPFBA60CDC6CCCED33
annotation: SIPFF0C0512F5F632BB
annotation: SIP02F99FC15463BDA3
annotation: SIPC5FADEAB54A8148D
annotation: PRO_0000112715
annotation: SIP206C70A72BB6A6FD
annotation: SIPC1D22904C3877D13
annotation: SIPA58CD165FC81F37F
annotation: SIPF635796B4640A978
annotation: SIP911ACDDFB1BEAB7A
annotation: SIP62CA78675C12F7FD
annotation: SIP170C22C3E97C21E1
annotation: SIP0731218A030EE442
annotation: SIP0E729DA8FB1A267E
annotation: SIP8AE57F8E161170CC
annotation: SIPED1BF99C19050E40
annotation: SIP98FA3329BA9DC3ED
annotation: SIP5967DE213A3D6040
annotation: SIP4F490A470190FCAF
annotation: SIPDF0666341C2B34D6
annotation: SIP37E9EDAFDFF4FEF6
annotation: SIPF7540DDCD64479DD
annotation: SIP6923CE705B9962CB
annotation: SIP5EBA4CFEA3CD214E
annotation: SIP52C663B36A92C57A
annotation: SIP1B41D85DB22A4068
annotation: SIP7E6347208F3B026E
annotation: SIP932D269C7EB13234
annotation: SIP05A7F55E7AA8ADD8
annotation: SIP2DF77C0B069E5090
annotation: SIP149C5D9B7E23A43E
annotation: SIP69BDEB7D58CC1962
annotation: SIP7410E365C47DB223
annotation: SIP33380E68EF583F6B
annotation: SIP0046D361D6702B6F
annotation: SIP9A749BE5F42A0B7F
annotation: SIP4B64C1ECB8CF955E
annotation: SIP6E0EEE287DC2FF7C
annotation: SIPBAFF8782A223158F
annotation: SIP1AD56B9FBA5E7C56
annotation: SIPBB83692DAEB64825
annotation: SIP28EF23D094031567
annotation: SIP9AA84A1DCE6FA72D
annotation: SIPEF32FB05A5393297
annotation: SIP47B8352A2C713F6D
annotation: SIP46C08B41A7A84047
annotation: SIPC543D99570D906FE
annotation: SIP715FBA630EF9A04E
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/32
classified with: http://purl.uniprot.org/keywords/55
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/663
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005737
classified with: GO_0042802
classified with: GO_0003992
classified with: GO_0030170
classified with: GO_0006526
sequence: O66442-1
proteome: Chromosome

O66442-citation-9537320
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

VF5
type: Strain

SIPF7E93D309AD4AD8
type: Submission Citation
title: Crystal structure of acetylornithine aminotransferase from Aquifex aeolicus vf5.
group: RIKEN structural genomics initiative (RSGI)
date: 2009-02
submitted to: PDB

O66442-citation-SIPF7E93D309AD4AD8
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 2-376 IN COMPLEX WITH PLP

2EH6
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 1.90
chain sequence mapping: PDB 2EH6 tt2tt376

PDB 2EH6 tt2tt376
chain: A/B=2-376

COG4992
type: Resource
database: eggNOG
comment: Bacteria

cd00610
type: Resource
database: CDD
comment: OAT_like
signature sequence match: CDD cd00610 match 1

MF_01107
type: Resource
database: HAMAP
comment: ArgD_aminotrans_3
signature sequence match: HAMAP MF 01107 match 1

IPR004636
type: Resource
database: InterPro
comment: AcOrn/SuccOrn_fam

IPR005814
type: Resource
database: InterPro
comment: Aminotrans_3

TIGR00707
type: Resource
database: NCBIfam
comment: argD
signature sequence match: NCBIfam TIGR00707 match 1

PTHR11986:SF79
type: Resource
database: PANTHER
comment: ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
signature sequence match: PANTHER PTHR11986:SF79 match 1

PTHR11986
type: Resource
database: PANTHER
comment: AMINOTRANSFERASE CLASS III
signature sequence match: PANTHER PTHR11986 match 1

PF00202
type: Resource
database: Pfam
comment: Aminotran_3
signature sequence match: Pfam PF00202 match 1

PIRSF000521
type: Resource
database: PIRSF
comment: Transaminase_4ab_Lys_Orn
signature sequence match: PIRSF PIRSF000521 match 1

PS00600
type: Resource
database: PROSITE
comment: AA_TRANSFER_CLASS_3
signature sequence match: PROSITE PS00600 match 1

SIPBA190430D12FCA08
type: Structured Name
full name: Acetylornithine aminotransferase
short name: ACOAT
ec name: 2.6.1.11

argD
type: Gene
locus name: aq_023

SIPAD25EA273272B13C
type: Cofactor Annotation
comment: Binds 1 pyridoxal phosphate per subunit.
cofactor: CHEBI_597326

SIPFBA60CDC6CCCED33
type: Subunit Annotation
comment: Homodimer.

SIP02F99FC15463BDA3
type: Annotation
comment: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

SIPC5FADEAB54A8148D
type: Similarity Annotation
comment: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.

PRO_0000112715
type: Chain Annotation
comment: Acetylornithine aminotransferase
mass: 42009
range: 22296129592111662tt1tt376

22296129592111662tt1
type: Position
type: ExactPosition
position: 1
reference: O66442-1

22296129592111662tt376
type: Position
type: ExactPosition
position: 376
reference: O66442-1

22296129592111662tt96
type: Position
type: ExactPosition
position: 96
reference: O66442-1

22296129592111662tt97
type: Position
type: ExactPosition
position: 97
reference: O66442-1

22296129592111662tt128
type: Position
type: ExactPosition
position: 128
reference: O66442-1

22296129592111662tt131
type: Position
type: ExactPosition
position: 131
reference: O66442-1

22296129592111662tt213
type: Position
type: ExactPosition
position: 213
reference: O66442-1

22296129592111662tt216
type: Position
type: ExactPosition
position: 216
reference: O66442-1

22296129592111662tt270
type: Position
type: ExactPosition
position: 270
reference: O66442-1

22296129592111662tt271
type: Position
type: ExactPosition
position: 271
reference: O66442-1

SIP170C22C3E97C21E1
type: Modified Residue Annotation
comment: N6-(pyridoxal phosphate)lysine
range: 22296129592111662tt242tt242

22296129592111662tt242
type: Position
type: ExactPosition
position: 242
reference: O66442-1

22296129592111662tt11
type: Position
type: ExactPosition
position: 11
reference: O66442-1

22296129592111662tt20
type: Position
type: ExactPosition
position: 20
reference: O66442-1

22296129592111662tt22
type: Position
type: ExactPosition
position: 22
reference: O66442-1

22296129592111662tt25
type: Position
type: ExactPosition
position: 25
reference: O66442-1

22296129592111662tt30
type: Position
type: ExactPosition
position: 30
reference: O66442-1

22296129592111662tt35
type: Position
type: ExactPosition
position: 35
reference: O66442-1

22296129592111662tt36
type: Position
type: ExactPosition
position: 36
reference: O66442-1

22296129592111662tt39
type: Position
type: ExactPosition
position: 39
reference: O66442-1

22296129592111662tt48
type: Position
type: ExactPosition
position: 48
reference: O66442-1

22296129592111662tt60
type: Position
type: ExactPosition
position: 60
reference: O66442-1

22296129592111662tt71
type: Position
type: ExactPosition
position: 71
reference: O66442-1

22296129592111662tt82
type: Position
type: ExactPosition
position: 82
reference: O66442-1

22296129592111662tt84
type: Position
type: ExactPosition
position: 84
reference: O66442-1

22296129592111662tt86
type: Position
type: ExactPosition
position: 86
reference: O66442-1

22296129592111662tt88
type: Position
type: ExactPosition
position: 88
reference: O66442-1

22296129592111662tt95
type: Position
type: ExactPosition
position: 95
reference: O66442-1

22296129592111662tt113
type: Position
type: ExactPosition
position: 113
reference: O66442-1

22296129592111662tt120
type: Position
type: ExactPosition
position: 120
reference: O66442-1

22296129592111662tt125
type: Position
type: ExactPosition
position: 125
reference: O66442-1

22296129592111662tt133
type: Position
type: ExactPosition
position: 133
reference: O66442-1

22296129592111662tt138
type: Position
type: ExactPosition
position: 138
reference: O66442-1

22296129592111662tt142
type: Position
type: ExactPosition
position: 142
reference: O66442-1

22296129592111662tt144
type: Position
type: ExactPosition
position: 144
reference: O66442-1

22296129592111662tt145
type: Position
type: ExactPosition
position: 145
reference: O66442-1

22296129592111662tt148
type: Position
type: ExactPosition
position: 148
reference: O66442-1

22296129592111662tt153
type: Position
type: ExactPosition
position: 153
reference: O66442-1

22296129592111662tt158
type: Position
type: ExactPosition
position: 158
reference: O66442-1

22296129592111662tt163
type: Position
type: ExactPosition
position: 163
reference: O66442-1

22296129592111662tt167
type: Position
type: ExactPosition
position: 167
reference: O66442-1

22296129592111662tt174
type: Position
type: ExactPosition
position: 174
reference: O66442-1

22296129592111662tt179
type: Position
type: ExactPosition
position: 179
reference: O66442-1

22296129592111662tt181
type: Position
type: ExactPosition
position: 181
reference: O66442-1

22296129592111662tt183
type: Position
type: ExactPosition
position: 183
reference: O66442-1

22296129592111662tt184
type: Position
type: ExactPosition
position: 184
reference: O66442-1

22296129592111662tt187
type: Position
type: ExactPosition
position: 187
reference: O66442-1

22296129592111662tt188
type: Position
type: ExactPosition
position: 188
reference: O66442-1

22296129592111662tt190
type: Position
type: ExactPosition
position: 190
reference: O66442-1

22296129592111662tt193
type: Position
type: ExactPosition
position: 193
reference: O66442-1

22296129592111662tt206
type: Position
type: ExactPosition
position: 206
reference: O66442-1

22296129592111662tt209
type: Position
type: ExactPosition
position: 209
reference: O66442-1

22296129592111662tt215
type: Position
type: ExactPosition
position: 215
reference: O66442-1

22296129592111662tt222
type: Position
type: ExactPosition
position: 222
reference: O66442-1

22296129592111662tt223
type: Position
type: ExactPosition
position: 223
reference: O66442-1

22296129592111662tt226
type: Position
type: ExactPosition
position: 226
reference: O66442-1

22296129592111662tt227
type: Position
type: ExactPosition
position: 227
reference: O66442-1

22296129592111662tt231
type: Position
type: ExactPosition
position: 231
reference: O66442-1

22296129592111662tt236
type: Position
type: ExactPosition
position: 236
reference: O66442-1

22296129592111662tt240
type: Position
type: ExactPosition
position: 240
reference: O66442-1

22296129592111662tt245
type: Position
type: ExactPosition
position: 245
reference: O66442-1

22296129592111662tt251
type: Position
type: ExactPosition
position: 251
reference: O66442-1

22296129592111662tt256
type: Position
type: ExactPosition
position: 256
reference: O66442-1

22296129592111662tt257
type: Position
type: ExactPosition
position: 257
reference: O66442-1

22296129592111662tt260
type: Position
type: ExactPosition
position: 260
reference: O66442-1

22296129592111662tt276
type: Position
type: ExactPosition
position: 276
reference: O66442-1

22296129592111662tt309
type: Position
type: ExactPosition
position: 309
reference: O66442-1

22296129592111662tt312
type: Position
type: ExactPosition
position: 312
reference: O66442-1

22296129592111662tt318
type: Position
type: ExactPosition
position: 318
reference: O66442-1

22296129592111662tt321
type: Position
type: ExactPosition
position: 321
reference: O66442-1

22296129592111662tt325
type: Position
type: ExactPosition
position: 325
reference: O66442-1

22296129592111662tt331
type: Position
type: ExactPosition
position: 331
reference: O66442-1

22296129592111662tt339
type: Position
type: ExactPosition
position: 339
reference: O66442-1

22296129592111662tt345
type: Position
type: ExactPosition
position: 345
reference: O66442-1

22296129592111662tt347
type: Position
type: ExactPosition
position: 347
reference: O66442-1

22296129592111662tt348
type: Position
type: ExactPosition
position: 348
reference: O66442-1

22296129592111662tt350
type: Position
type: ExactPosition
position: 350
reference: O66442-1

22296129592111662tt351
type: Position
type: ExactPosition
position: 351
reference: O66442-1

22296129592111662tt354
type: Position
type: ExactPosition
position: 354
reference: O66442-1

22296129592111662tt362
type: Position
type: ExactPosition
position: 362
reference: O66442-1

22296129592111662tt375
type: Position
type: ExactPosition
position: 375
reference: O66442-1

O66442-1
type: Simple Sequence
modified: 1998-08-01
version: 1
mass: 42009
value: MTYLMNNYARLPVKFVRGKGVYLYDEEGKEYLDFVSGIGVNSLGHAYPKLTEALKEQVEKLLHVSNLYENPWQEELAHKLVKHFWTEGKVFFANSGTESVEAAIKLARKYWRDKGKNKWKFISFENSFHGRTYGSLSATGQPKFHKGFEPLVPGFSYAKLNDIDSVYKLLDEETAGIIIEVIQGEGGVNEASEDFLSKLQEICKEKDVLLIIDEVQTGIGRTGEFYAYQHFNLKPDVIALAKGLGGGVPIGAILAREEVAQSFTPGSHGSTFGGNPLACRAGTVVVDEVEKLLPHVREVGNYFKEKLKELGKGKVKGRGLMLGLELERECKDYVLKALEKGLLINCTAGKVLRFLPPLIIQKEHIDRAISVLREIL

http://purl.uniprot.org/uniprot/O66442#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/O66442#attribution-2186C6D0B4999FFA56F2B72ADE282272
manual: true
evidence: ECO_0000255
source: MF_01107

http://purl.uniprot.org/uniprot/O66442#attribution-D5C83BA4784F00FA6C41293E4E18C39C
manual: true
evidence: ECO_0000269
source: SIPF7E93D309AD4AD8

http://purl.uniprot.org/uniprot/O66442#attribution-EAA1A606AA9E08BF256BA1F62037BBCE
manual: true
evidence: ECO_0000305
source: SIPF7E93D309AD4AD8

O67100
type: Protein
reviewed: true
created: 2003-04-23
modified: 2023-09-13
version: 126
mnemonic: ARGJ_AQUAE
citation: http://purl.uniprot.org/citations/9537320
recommended name: SIP022382BBF7D54A33
component: SIP3453D18D62F9A4A5
component: SIP48ED11D09BF26724
domain: SIP635ECCB2D91530A6
domain: SIPB192CD20DB70B985
organism: http://purl.uniprot.org/taxonomy/224324
annotation: SIP352529A8E2BCCF1D
annotation: SIP703EF90955772730
annotation: SIP566DE18776209E13
annotation: SIPC94DC0DF027CECFB
annotation: SIP3C0FE8522A977F8C
annotation: SIP9FBCE998D7677768
annotation: SIP9538AAA09337D4A6
annotation: SIP4DA57BF7C454A0DF
annotation: SIP9C974A9FA088765B
annotation: PRO_0000002101
annotation: PRO_0000002102
annotation: SIPF31D69A216E824FB
annotation: SIP8405B3DB76DBBE76
annotation: SIPBC5E7D06685A2858
annotation: SIP179DDFBD14EB77D1
annotation: SIP14E798EB165DADB2
annotation: SIP856DC8FB43AA35A3
annotation: SIPD104A626FA644C6E
annotation: SIPF54D3BBDAF086332
annotation: SIPCB416B3AEEE2F36D
annotation: SIPB2FA5E4393EF2F36
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/12
classified with: http://purl.uniprot.org/keywords/55
classified with: http://purl.uniprot.org/keywords/68
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/511
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005737
classified with: GO_0004042
classified with: GO_0004358
classified with: GO_0103045
classified with: GO_0006526
classified with: GO_0006592
sequence: O67100-1
proteome: Chromosome

O67100-citation-9537320
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

VF5
type: Strain

COG1364
type: Resource
database: eggNOG
comment: Bacteria

cd02152
type: Resource
database: CDD
comment: OAT
signature sequence match: CDD cd02152 match 1

http://purl.uniprot.org/gene3d/3.10.20.340
type: Resource
database: Gene3D
comment: ArgJ beta chain, C-terminal domain
signature sequence match: Gene3D 3.10.20.340 match 1

http://purl.uniprot.org/gene3d/3.60.70.12
type: Resource
database: Gene3D
comment: L-amino peptidase D-ALA esterase/amidase
signature sequence match: Gene3D 3.60.70.12 match 1

MF_01106
type: Resource
database: HAMAP
comment: ArgJ
signature sequence match: HAMAP MF 01106 match 1

IPR002813
type: Resource
database: InterPro
comment: Arg_biosynth_ArgJ

IPR016117
type: Resource
database: InterPro
comment: ArgJ-like_dom_sf

IPR042195
type: Resource
database: InterPro
comment: ArgJ_beta_C

TIGR00120
type: Resource
database: NCBIfam
comment: ArgJ
signature sequence match: NCBIfam TIGR00120 match 1

PTHR23100
type: Resource
database: PANTHER
comment: ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ
signature sequence match: PANTHER PTHR23100 match 1

PTHR23100:SF0
type: Resource
database: PANTHER
comment: ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ, MITOCHONDRIAL
signature sequence match: PANTHER PTHR23100:SF0 match 1

PF01960
type: Resource
database: Pfam
comment: ArgJ
signature sequence match: Pfam PF01960 match 1

SSF56266
type: Resource
database: SUPFAM
comment: DmpA/ArgJ-like
signature sequence match: SUPFAM SSF56266 match 1

SIP022382BBF7D54A33
type: Structured Name
full name: Arginine biosynthesis bifunctional protein ArgJ

SIP7E29D56129CC8C34
type: Structured Name
full name: Arginine biosynthesis bifunctional protein ArgJ alpha chain

SIP23AEA617DD01AC8B
type: Structured Name
full name: Arginine biosynthesis bifunctional protein ArgJ beta chain

SIP444E498C0E0EE8C0
type: Structured Name
full name: Glutamate N-acetyltransferase
ec name: 2.3.1.35

SIP866CF057B35B5BD0
type: Structured Name
full name: Ornithine acetyltransferase
short name: OATase

SIP38E1C293C5AE134B
type: Structured Name
full name: Ornithine transacetylase

SIP90766EB72388F942
type: Structured Name
full name: Amino-acid acetyltransferase
ec name: 2.3.1.1

SIP85167C636FAAAD00
type: Structured Name
full name: N-acetylglutamate synthase
short name: AGSase

argJ
type: Gene
locus name: aq_970

SIP352529A8E2BCCF1D
type: Function Annotation
comment: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.

SIP9FBCE998D7677768
type: Subunit Annotation
comment: Heterotetramer of two alpha and two beta chains.

SIP4DA57BF7C454A0DF
type: Annotation
comment: Some bacteria possess a monofunctional ArgJ, i.e. capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

SIP9C974A9FA088765B
type: Similarity Annotation
comment: Belongs to the ArgJ family.

PRO_0000002101
type: Chain Annotation
comment: Arginine biosynthesis bifunctional protein ArgJ alpha chain
mass: 18839
range: 22296133836484654tt1tt173

22296133836484654tt1
type: Position
type: ExactPosition
position: 1
reference: O67100-1

22296133836484654tt173
type: Position
type: ExactPosition
position: 173
reference: O67100-1

PRO_0000002102
type: Chain Annotation
comment: Arginine biosynthesis bifunctional protein ArgJ beta chain
mass: 22923
range: 22296133836484654tt174tt379

22296133836484654tt174
type: Position
type: ExactPosition
position: 174
reference: O67100-1

22296133836484654tt379
type: Position
type: ExactPosition
position: 379
reference: O67100-1

SIPF31D69A216E824FB
type: Active Site Annotation
comment: Nucleophile
range: 22296133836484654tt174tt174

22296133836484654tt141
type: Position
type: ExactPosition
position: 141
reference: O67100-1

22296133836484654tt163
type: Position
type: ExactPosition
position: 163
reference: O67100-1

22296133836484654tt252
type: Position
type: ExactPosition
position: 252
reference: O67100-1

22296133836484654tt374
type: Position
type: ExactPosition
position: 374
reference: O67100-1

SIPF54D3BBDAF086332
type: Site Annotation
comment: Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
range: 22296133836484654tt104tt104

22296133836484654tt104
type: Position
type: ExactPosition
position: 104
reference: O67100-1

SIPCB416B3AEEE2F36D
type: Site Annotation
comment: Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
range: 22296133836484654tt105tt105

22296133836484654tt105
type: Position
type: ExactPosition
position: 105
reference: O67100-1

SIPB2FA5E4393EF2F36
type: Site Annotation
comment: Cleavage; by autolysis
range: 22296133836484654tt173tt174

substrate

O67100-1
type: Simple Sequence
modified: 1998-08-01
version: 1
mass: 41743
value: MAEILMGVGNAGLKESGNPDILVVYLPYPCTASFVFTDNYFKAGSVIYSERIARDKERIRAFVVNSGNANCGTGEEGIKHAEMMAEKVAQILDIPKDEVFVFSTGIIGKYLPIENVLKGIEQACSNLELLDLKRASEVISTTDRFPKYDFAKAGEVETFGFAKGAGMIHPSMATMLAFVFTNANLEYLTLKRIHESVTEKTFNSITVDGCESTNDAFGIISLGEVEADPETVEFELLKVSESLAKQIVADGEGATKIIRVNVRSAITEIKAREIAEAIANSLLVKTAVFGRDPNWGRIAAAAGSTEFPIDPFKLEIYVGGYLLYDGKPHDENLEKAKKHLIEDREVDITVELNEGEYEWVCYSSDIGYDYIKLNAEYTT

http://purl.uniprot.org/uniprot/O67100#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/O67100#attribution-F496447504F9DFE66FA5F3E79E582F6A
manual: true
evidence: ECO_0000255
source: MF_01106

O67383
type: Protein
reviewed: true
created: 2000-05-30
modified: 2023-09-13
version: 137
mnemonic: ARLY_AQUAE
citation: http://purl.uniprot.org/citations/9537320
recommended name: SIPF4A3D1B656DFDAB4
alternative name: SIPDBF6261F74BBA4CD
enzyme: http://purl.uniprot.org/enzyme/4.3.2.1
organism: http://purl.uniprot.org/taxonomy/224324
annotation: SIP22DBD5D0710D6C08
annotation: SIPA190E64984037789
annotation: SIP43962C576A1E7BFC
annotation: SIPF1BEBE6F0214E102
annotation: PRO_0000137733
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/55
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/456
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005829
classified with: GO_0004056
classified with: GO_0042450
sequence: O67383-1
proteome: Chromosome

O67383-citation-9537320
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

VF5
type: Strain

COG0165
type: Resource
database: eggNOG
comment: Bacteria

cd01359
type: Resource
database: CDD
comment: Argininosuccinate_lyase
signature sequence match: CDD cd01359 match 1

http://purl.uniprot.org/gene3d/1.10.40.30
type: Resource
database: Gene3D
comment: Fumarase/aspartase (C-terminal domain)
signature sequence match: Gene3D 1.10.40.30 match 1

http://purl.uniprot.org/gene3d/1.20.200.10
type: Resource
database: Gene3D
comment: Fumarase/aspartase (Central domain)
signature sequence match: Gene3D 1.20.200.10 match 1

http://purl.uniprot.org/gene3d/1.10.275.10
type: Resource
database: Gene3D
comment: Fumarase/aspartase (N-terminal domain)
signature sequence match: Gene3D 1.10.275.10 match 1

MF_00006
type: Resource
database: HAMAP
comment: Arg_succ_lyase
signature sequence match: HAMAP MF 00006 match 1

IPR029419
type: Resource
database: InterPro
comment: Arg_succ_lyase_C

IPR009049
type: Resource
database: InterPro
comment: Argininosuccinate_lyase

IPR024083
type: Resource
database: InterPro
comment: Fumarase/histidase_N

IPR020557
type: Resource
database: InterPro
comment: Fumarate_lyase_CS

IPR000362
type: Resource
database: InterPro
comment: Fumarate_lyase_fam

IPR022761
type: Resource
database: InterPro
comment: Fumarate_lyase_N

IPR008948
type: Resource
database: InterPro
comment: L-Aspartase-like

TIGR00838
type: Resource
database: NCBIfam
comment: argH
signature sequence match: NCBIfam TIGR00838 match 1

PTHR43814
type: Resource
database: PANTHER
comment: ARGININOSUCCINATE LYASE
signature sequence match: PANTHER PTHR43814 match 1

PTHR43814:SF1
type: Resource
database: PANTHER
comment: ARGININOSUCCINATE LYASE
signature sequence match: PANTHER PTHR43814:SF1 match 1

PF14698
type: Resource
database: Pfam
comment: ASL_C2
signature sequence match: Pfam PF14698 match 1

PF00206
type: Resource
database: Pfam
comment: Lyase_1
signature sequence match: Pfam PF00206 match 1

PR00145
type: Resource
database: PRINTS
comment: ARGSUCLYASE

PR00149
type: Resource
database: PRINTS
comment: FUMRATELYASE

SSF48557
type: Resource
database: SUPFAM
comment: L-aspartase-like
signature sequence match: SUPFAM SSF48557 match 1

PS00163
type: Resource
database: PROSITE
comment: FUMARATE_LYASES
signature sequence match: PROSITE PS00163 match 1

SIPF4A3D1B656DFDAB4
type: Structured Name
full name: Argininosuccinate lyase
short name: ASAL
ec name: 4.3.2.1

SIPDBF6261F74BBA4CD
type: Structured Name
full name: Arginosuccinase

argH
type: Gene
locus name: aq_1372

SIPF1BEBE6F0214E102
type: Similarity Annotation
comment: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

PRO_0000137733
type: Chain Annotation
comment: Argininosuccinate lyase
mass: 52838
range: 22296133870564142tt1tt457

22296133870564142tt1
type: Position
type: ExactPosition
position: 1
reference: O67383-1

22296133870564142tt457
type: Position
type: ExactPosition
position: 457
reference: O67383-1

O67383-1
type: Simple Sequence
modified: 1998-08-01
version: 1
mass: 52838
value: MEKPWSGRFKEETDKFVEDFTESVSFDKELAFEDIEQDIAHVKTLQKAGILTEEEARELIQELLKIKEEIKEGKFQWKKELEDVHMNIEAELINRLGDVGRKLHTARSRNDQVATDEKLYLKKEIKEVLQLLKELRKTLVELAETTVDFVMPSYTHLQRAQPIRVAHYFLAYREILLKDSERLMDTYRRVDELPLGSGAVAGVDFPLDRFYTAELLGFNRVTRNSMYATAERDFIIEFLSNCALIAQHLSRLAEDLIIWNTEEFNFVELPDKLCTGSSIMPQKKNPDVLELIRGKTGRIYGNLIALLTTMKALPMAYNRDMQEDKEPLFDTLKNLKNMIKGMTLVLSDLRVKEQNMRKASGNFLLITDIANYLVEKGVPFRTAHHIAGSIVAYLLEKGKKLEEMTLEEFKQFSEKFEEDVFDILSPERAADRKRVYGGTAKEEILRIIEVAKAEEGL

http://purl.uniprot.org/uniprot/O67383#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/O67383#attribution-E70757EF0AE2BC1F2EB5F5AA89A36E23
manual: true
evidence: ECO_0000255
source: MF_00006

B4U6T9
type: Protein
reviewed: true
created: 2009-07-28
modified: 2023-09-13
version: 78
mnemonic: ARLY_HYDS0
citation: http://purl.uniprot.org/citations/19136599
recommended name: SIPF4A3D1B656DFDAB4
alternative name: SIPDBF6261F74BBA4CD
enzyme: http://purl.uniprot.org/enzyme/4.3.2.1
organism: http://purl.uniprot.org/taxonomy/380749
annotation: SIPE623C41DECF4B253
annotation: SIPE0621866CF5DE780
annotation: SIP586A3DFD67839A42
annotation: SIP52329FA445A5971F
annotation: PRO_1000116327
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/55
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/456
classified with: GO_0005737
classified with: GO_0004056
classified with: GO_0042450
sequence: B4U6T9-1

B4U6T9-citation-19136599
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

Y04AAS1
type: Strain

SIPF4A3D1B656DFDAB4
type: Structured Name
full name: Argininosuccinate lyase
short name: ASAL
ec name: 4.3.2.1

SIPDBF6261F74BBA4CD
type: Structured Name
full name: Arginosuccinase

argH
type: Gene
locus name: HY04AAS1_0158

SIP52329FA445A5971F
type: Similarity Annotation
comment: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

PRO_1000116327
type: Chain Annotation
comment: Argininosuccinate lyase
mass: 52561
range: 18634889051257134tt1tt458

18634889051257134tt1
type: Position
type: ExactPosition
position: 1
reference: B4U6T9-1

18634889051257134tt458
type: Position
type: ExactPosition
position: 458
reference: B4U6T9-1

B4U6T9-1
type: Simple Sequence
modified: 2008-09-23
version: 1
mass: 52561
value: MSKAWSGRFKEDTSKDVELFTESISFDKALAMYDLEQDFAHLEALLKAGVISKDSYENIKSGLKKIKQEIEKNEFYFDISKEDIHMNIESRLYELIGEDAKKLHTGRSRNDQVNTDLRLYLKDHILKIFELLKALKQQLVLKAKEYEDLIMPGYTHLQRAQPVLVAHYLLSFKEAFLRDSQRLIDAYRRIDTLTLGSGALAGADFPLDRFLEASILNFSKISRNSMDAVADRDFAIEYMFCLSSIAMHLSRMAEDFIIFNTEEFKFIDLPDSLCTGSSIMPQKKNPDVLELIRGKAGRVYANLINLMVNLKGLPMTYNRDLQEDKEPIFDATNTILNSLKMMILIIKDIRFRQNIEAGNLLLATDLANYLVEKNIPFREAHHIVGNIVAYAIENQKPLESLTKEELNNFSKAFDKDAKDIISKESSILRKKTYGSTNKDFVKKQIDLSSSEESIDKNL

http://purl.uniprot.org/uniprot/B4U6T9#attribution-E70757EF0AE2BC1F2EB5F5AA89A36E23
manual: true
evidence: ECO_0000255
source: MF_00006

B2V6Y7
type: Protein
reviewed: true
created: 2009-03-24
modified: 2023-09-13
version: 82
mnemonic: ARLY_SULSY
citation: http://purl.uniprot.org/citations/19136599
recommended name: SIPF4A3D1B656DFDAB4
alternative name: SIPDBF6261F74BBA4CD
enzyme: http://purl.uniprot.org/enzyme/4.3.2.1
organism: http://purl.uniprot.org/taxonomy/436114
annotation: SIPFBB327B2DB4F9819
annotation: SIPDEDCDEB2DD86498A
annotation: SIPE1D65F86ECA5B7BC
annotation: SIP0E790F78F3EA84C1
annotation: PRO_1000089123
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/55
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/456
classified with: GO_0005737
classified with: GO_0004056
classified with: GO_0042450
sequence: B2V6Y7-1

B2V6Y7-citation-19136599
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

YO3AOP1
type: Strain

SIPF4A3D1B656DFDAB4
type: Structured Name
full name: Argininosuccinate lyase
short name: ASAL
ec name: 4.3.2.1

SIPDBF6261F74BBA4CD
type: Structured Name
full name: Arginosuccinase

argH
type: Gene
locus name: SYO3AOP1_0123

SIP0E790F78F3EA84C1
type: Similarity Annotation
comment: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

PRO_1000089123
type: Chain Annotation
comment: Argininosuccinate lyase
mass: 51963
range: 18632694323296046tt1tt459

18632694323296046tt1
type: Position
type: ExactPosition
position: 1
reference: B2V6Y7-1

18632694323296046tt459
type: Position
type: ExactPosition
position: 459
reference: B2V6Y7-1

B2V6Y7-1
type: Simple Sequence
modified: 2008-07-01
version: 1
mass: 51963
value: MQEKKLWGGRFSESTDAFVEEFTESISFDKELALYDIKGSMAHAKMLGKQGIIPQEDAEKIVKGLQDIEQEIKENKFVWKKELEDVHMNIEKALTDKIGKAGGKLHTGRSRNDQVITAFRLYLKENTQDIINLLEDLQRKLLEKAKEYIDVVMPAYTHLQRAQPIRAAHYFLAYLEMFQRDKERFIDNLKRIDMLPLGSGAVAGVDFPIDREYVAKELGFSQIMRNSIDATSSRDFALEFLSNCAICMANMSRFSEDMIIYSSSEFSFVELPDKLTTGSSIMPQKKNPDVLELIRGKTGRVYGNLISLLTVVKGLPLAYNRDLQEDKGPVFDSVKTIKGSIIGITKIVEGLKLNREKTQLAAGGFALATDLANYLAEKGVPFRQAHHIVGSIVGYLVNQGRELESITLEELKQFSHLFEEDALKLLSPFVVADRRKSFGGTAKEQILSQIEYWDKILNK

http://purl.uniprot.org/uniprot/B2V6Y7#attribution-E70757EF0AE2BC1F2EB5F5AA89A36E23
manual: true
evidence: ECO_0000255
source: MF_00006

O67494
type: Protein
reviewed: true
created: 2000-05-30
modified: 2023-09-13
version: 129
mnemonic: AROA_AQUAE
citation: http://purl.uniprot.org/citations/9537320
recommended name: SIP9B7B8EEDD6AC7691
alternative name: SIP7BCBDA8035E4F966
enzyme: http://purl.uniprot.org/enzyme/2.5.1.19
organism: http://purl.uniprot.org/taxonomy/224324
annotation: SIP0283E0F3746CA43F
annotation: SIP5DDD12BA025BE67A
annotation: SIP028D43D3D51AD175
annotation: SIP32B0AD5022ABD1EB
annotation: SIP34D477FA98BB49FB
annotation: SIP67418980E201C8CC
annotation: PRO_0000088217
annotation: SIPE132714E771771CC
annotation: SIP799B664B917842E4
annotation: SIP9E2BE789217BBBD3
annotation: SIPE737FE88991C2F5E
annotation: SIPE22075EE6A92C939
annotation: SIPD1C5EA3883A092FB
annotation: SIP0B09C04C29141FDD
annotation: SIP7B45FBBB619FE502
annotation: SIP649B632BCFE3BC4B
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/57
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/808
classified with: GO_0005737
classified with: GO_0003866
classified with: GO_0008652
classified with: GO_0009073
classified with: GO_0009423
sequence: O67494-1
proteome: Chromosome

O67494-citation-9537320
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

VF5
type: Strain

COG0128
type: Resource
database: eggNOG
comment: Bacteria

cd01556
type: Resource
database: CDD
comment: EPSP_synthase
signature sequence match: CDD cd01556 match 1

http://purl.uniprot.org/gene3d/3.65.10.10
type: Resource
database: Gene3D
comment: Enolpyruvate transferase domain
signature sequence match: Gene3D 3.65.10.10 match 1
signature sequence match: Gene3D 3.65.10.10 match 2

MF_00210
type: Resource
database: HAMAP
comment: EPSP_synth
signature sequence match: HAMAP MF 00210 match 1

IPR001986
type: Resource
database: InterPro
comment: Enolpyruvate_Tfrase_dom

IPR036968
type: Resource
database: InterPro
comment: Enolpyruvate_Tfrase_sf

IPR006264
type: Resource
database: InterPro
comment: EPSP_synthase

IPR023193
type: Resource
database: InterPro
comment: EPSP_synthase_CS

IPR013792
type: Resource
database: InterPro
comment: RNA3'P_cycl/enolpyr_Trfase_a/b

TIGR01356
type: Resource
database: NCBIfam
comment: aroA
signature sequence match: NCBIfam TIGR01356 match 1

PTHR21090
type: Resource
database: PANTHER
comment: AROM/DEHYDROQUINATE SYNTHASE
signature sequence match: PANTHER PTHR21090 match 1

PTHR21090:SF5
type: Resource
database: PANTHER
comment: PENTAFUNCTIONAL AROM POLYPEPTIDE
signature sequence match: PANTHER PTHR21090:SF5 match 1

PF00275
type: Resource
database: Pfam
comment: EPSP_synthase
signature sequence match: Pfam PF00275 match 1

PIRSF000505
type: Resource
database: PIRSF
comment: EPSPS
signature sequence match: PIRSF PIRSF000505 match 1

SSF55205
type: Resource
database: SUPFAM
comment: EPT/RTPC-like
signature sequence match: SUPFAM SSF55205 match 1

PS00104
type: Resource
database: PROSITE
comment: EPSP_SYNTHASE_1
signature sequence match: PROSITE PS00104 match 1

PS00885
type: Resource
database: PROSITE
comment: EPSP_SYNTHASE_2
signature sequence match: PROSITE PS00885 match 1

SIP9B7B8EEDD6AC7691
type: Structured Name
full name: 3-phosphoshikimate 1-carboxyvinyltransferase
ec name: 2.5.1.19

SIP7BCBDA8035E4F966
type: Structured Name
full name: 5-enolpyruvylshikimate-3-phosphate synthase
short name: EPSP synthase
short name: EPSPS

aroA
type: Gene
locus name: aq_1536

SIP0283E0F3746CA43F
type: Function Annotation
comment: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.

SIP32B0AD5022ABD1EB
type: Subunit Annotation
comment: Monomer.

SIP67418980E201C8CC
type: Similarity Annotation
comment: Belongs to the EPSP synthase family.

PRO_0000088217
type: Chain Annotation
comment: 3-phosphoshikimate 1-carboxyvinyltransferase
mass: 47793
range: 22296133887407150tt1tt431

22296133887407150tt1
type: Position
type: ExactPosition
position: 1
reference: O67494-1

22296133887407150tt431
type: Position
type: ExactPosition
position: 431
reference: O67494-1

SIPE132714E771771CC
type: Region Annotation
comment: Phosphoenolpyruvate
range: 22296133887407150tt89tt92

22296133887407150tt89
type: Position
type: ExactPosition
position: 89
reference: O67494-1

22296133887407150tt92
type: Position
type: ExactPosition
position: 92
reference: O67494-1

SIP799B664B917842E4
type: Active Site Annotation
comment: Proton acceptor
range: 22296133887407150tt317tt317

22296133887407150tt317
type: Position
type: ExactPosition
position: 317
reference: O67494-1

SIP9E2BE789217BBBD3
type: Active Site Annotation
comment: Proton donor
range: 22296133887407150tt345tt345

22296133887407150tt345
type: Position
type: ExactPosition
position: 345
reference: O67494-1

22296133887407150tt20
type: Position
type: ExactPosition
position: 20
reference: O67494-1

22296133887407150tt21
type: Position
type: ExactPosition
position: 21
reference: O67494-1

22296133887407150tt25
type: Position
type: ExactPosition
position: 25
reference: O67494-1

22296133887407150tt119
type: Position
type: ExactPosition
position: 119
reference: O67494-1

22296133887407150tt344
type: Position
type: ExactPosition
position: 344
reference: O67494-1

22296133887407150tt348
type: Position
type: ExactPosition
position: 348
reference: O67494-1

22296133887407150tt390
type: Position
type: ExactPosition
position: 390
reference: O67494-1

O67494-1
type: Simple Sequence
modified: 1998-08-01
version: 1
mass: 47793
value: MKKIEKIKRVKGELRVPSDKSITHRAFILGALASGETLVRKPLISGDTLATLEILKAIRTKVREGKEEVLIEGRNYTFLEPHDVLDAKNSGTTARIMSGVLSTQPFFSVLTGDESLKNRPMLRVVEPLREMGAKIDGREEGNKLPIAIRGGNLKGISYFNKKSSAQVKSALLLAGLRAEGMTEVVEPYLSRDHTERMLKLFGAEVITIPEERGHIVKIKGGQELQGTEVYCPADPSSAAYFAALATLAPEGEIRLKEVLLNPTRDGFYRKLIEMGGDISFENYRELSNEPMADLVVRPVDNLKPVKVSPEEVPTLIDEIPILAVLMAFADGVSEVKGAKELRYKESDRIKAIVTNLRKLGVQVEEFEDGFAIHGTKEIKGGVIETFKDHRIAMAFAVLGLVVEEEVIIDHPECVTVSYPEFWEDILKVVEF

http://purl.uniprot.org/uniprot/O67494#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/O67494#attribution-0A561F4F067256E9CA6406750D5E4A5F
manual: true
evidence: ECO_0000255
source: MF_00210

http://purl.uniprot.org/uniprot/O67494#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

C0QS40
type: Protein
reviewed: true
created: 2009-07-28
modified: 2023-09-13
version: 77
mnemonic: AROA_PERMH
citation: http://purl.uniprot.org/citations/19136599
recommended name: SIP9B7B8EEDD6AC7691
alternative name: SIP7BCBDA8035E4F966
enzyme: http://purl.uniprot.org/enzyme/2.5.1.19
organism: http://purl.uniprot.org/taxonomy/123214
annotation: SIP0B7914F8F5C32119
annotation: SIPC9D6FC3C2C326109
annotation: SIPFAE1C323BA9628F7
annotation: SIPFCD662E7091FA4FC
annotation: SIP1228361A9007371A
annotation: SIPCF53A0114CAA4200
annotation: PRO_1000124695
annotation: SIPD7F5C5CDCD2D1491
annotation: SIPBAD0C2312C4913B7
annotation: SIP59380BC632C72EFF
annotation: SIP00658B909DAFBD98
annotation: SIPCD72501FA016513D
annotation: SIPF5E8C681109FCEEB
annotation: SIP6E7BE8BDBE477319
annotation: SIP3DBC823E1DC46239
annotation: SIPD40E72DEA6D6E220
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/57
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/808
classified with: GO_0005737
classified with: GO_0003866
classified with: GO_0008652
classified with: GO_0009073
classified with: GO_0009423
sequence: C0QS40-1
proteome: Chromosome

C0QS40-citation-19136599
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

DSM 14350 / EX-H1
type: Strain

SIP9B7B8EEDD6AC7691
type: Structured Name
full name: 3-phosphoshikimate 1-carboxyvinyltransferase
ec name: 2.5.1.19

SIP7BCBDA8035E4F966
type: Structured Name
full name: 5-enolpyruvylshikimate-3-phosphate synthase
short name: EPSP synthase
short name: EPSPS

aroA
type: Gene
locus name: PERMA_1722

SIP0B7914F8F5C32119
type: Function Annotation
comment: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.

SIPFCD662E7091FA4FC
type: Subunit Annotation
comment: Monomer.

SIPCF53A0114CAA4200
type: Similarity Annotation
comment: Belongs to the EPSP synthase family.

PRO_1000124695
type: Chain Annotation
comment: 3-phosphoshikimate 1-carboxyvinyltransferase
mass: 47420
range: 18911949286027310tt1tt432

18911949286027310tt1
type: Position
type: ExactPosition
position: 1
reference: C0QS40-1

18911949286027310tt432
type: Position
type: ExactPosition
position: 432
reference: C0QS40-1

SIPD7F5C5CDCD2D1491
type: Region Annotation
comment: Phosphoenolpyruvate
range: 18911949286027310tt91tt94

18911949286027310tt91
type: Position
type: ExactPosition
position: 91
reference: C0QS40-1

18911949286027310tt94
type: Position
type: ExactPosition
position: 94
reference: C0QS40-1

SIPBAD0C2312C4913B7
type: Active Site Annotation
comment: Proton acceptor
range: 18911949286027310tt318tt318

18911949286027310tt318
type: Position
type: ExactPosition
position: 318
reference: C0QS40-1

SIP59380BC632C72EFF
type: Active Site Annotation
comment: Proton donor
range: 18911949286027310tt346tt346

18911949286027310tt346
type: Position
type: ExactPosition
position: 346
reference: C0QS40-1

18911949286027310tt21
type: Position
type: ExactPosition
position: 21
reference: C0QS40-1

18911949286027310tt22
type: Position
type: ExactPosition
position: 22
reference: C0QS40-1

18911949286027310tt26
type: Position
type: ExactPosition
position: 26
reference: C0QS40-1

18911949286027310tt121
type: Position
type: ExactPosition
position: 121
reference: C0QS40-1

18911949286027310tt345
type: Position
type: ExactPosition
position: 345
reference: C0QS40-1

18911949286027310tt349
type: Position
type: ExactPosition
position: 349
reference: C0QS40-1

18911949286027310tt391
type: Position
type: ExactPosition
position: 391
reference: C0QS40-1

C0QS40-1
type: Simple Sequence
modified: 2009-05-05
version: 1
mass: 47420
value: MEKEISKVSRIKGELRVPSDKSISHRSIILTSLADGVSVVKNFLKAGDTLTTLNVYRKLGVSIIEEKGVLKIKGVNLKGFKEPEDILDMGNSGTTTRLTLGLLSGQEFFSALTGDDSLRQRPMGRVADPLRSMGAKIDGRQDGKLLPLSVRGSSLKGIQFYNKRSSAQVKSALLIAGLLAEGKTKVTEPYISRDHTEKMLDAMGADIHIERDDEYSVTISGSKKLEGIEIDVPADPSSAAFFAAAAVLIPDSELLLKDVLINPTRDGFFRKLKEMGGDIRYTNIREKAKEPVADIYVRYSPDLKGIRIKKEDVPSMVDEIPLLSIVATQAEGETIITGAEELRVKESDRIKAVVENLKNLGIDVEELPDGMVIKGKQKVKGGVVDSYKDHRIAMGFSILGLISEEGIKIKDADSVFISYPEFYEHLERIISN

http://purl.uniprot.org/uniprot/C0QS40#attribution-0A561F4F067256E9CA6406750D5E4A5F
manual: true
evidence: ECO_0000255
source: MF_00210

B2V630
type: Protein
reviewed: true
created: 2009-03-24
modified: 2023-09-13
version: 87
mnemonic: AROA_SULSY
citation: http://purl.uniprot.org/citations/19136599
recommended name: SIP9B7B8EEDD6AC7691
alternative name: SIP7BCBDA8035E4F966
enzyme: http://purl.uniprot.org/enzyme/2.5.1.19
organism: http://purl.uniprot.org/taxonomy/436114
annotation: SIP139286B12FBC2172
annotation: SIPCBDF61AF81791852
annotation: SIPF9AC23621BB45E63
annotation: SIPE285855A9A73B7B8
annotation: SIP1FF59A3FFFBF67CB
annotation: SIP7B91749271821CAB
annotation: PRO_1000099758
annotation: SIP267251697B69E60D
annotation: SIP4AF80B3E989E8E70
annotation: SIP042EFCCB8BF6E4CD
annotation: SIPEE563F69E15F4DA5
annotation: SIP23CD6FCABE10DA2D
annotation: SIP79A91F050B962C81
annotation: SIP95ABF54D33F74B60
annotation: SIPE796DDD7B83CAAE9
annotation: SIP722AC6ADCA59CECD
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/57
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/808
classified with: GO_0005737
classified with: GO_0003866
classified with: GO_0008652
classified with: GO_0009073
classified with: GO_0009423
sequence: B2V630-1

B2V630-citation-19136599
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

YO3AOP1
type: Strain

SIP9B7B8EEDD6AC7691
type: Structured Name
full name: 3-phosphoshikimate 1-carboxyvinyltransferase
ec name: 2.5.1.19

SIP7BCBDA8035E4F966
type: Structured Name
full name: 5-enolpyruvylshikimate-3-phosphate synthase
short name: EPSP synthase
short name: EPSPS

aroA
type: Gene
locus name: SYO3AOP1_0004

SIP139286B12FBC2172
type: Function Annotation
comment: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.

SIPE285855A9A73B7B8
type: Subunit Annotation
comment: Monomer.

SIP7B91749271821CAB
type: Similarity Annotation
comment: Belongs to the EPSP synthase family.

PRO_1000099758
type: Chain Annotation
comment: 3-phosphoshikimate 1-carboxyvinyltransferase
mass: 47242
range: 18632694320803886tt1tt431

18632694320803886tt1
type: Position
type: ExactPosition
position: 1
reference: B2V630-1

18632694320803886tt431
type: Position
type: ExactPosition
position: 431
reference: B2V630-1

SIP267251697B69E60D
type: Region Annotation
comment: Phosphoenolpyruvate
range: 18632694320803886tt91tt94

18632694320803886tt91
type: Position
type: ExactPosition
position: 91
reference: B2V630-1

18632694320803886tt94
type: Position
type: ExactPosition
position: 94
reference: B2V630-1

SIP4AF80B3E989E8E70
type: Active Site Annotation
comment: Proton acceptor
range: 18632694320803886tt318tt318

18632694320803886tt318
type: Position
type: ExactPosition
position: 318
reference: B2V630-1

SIP042EFCCB8BF6E4CD
type: Active Site Annotation
comment: Proton donor
range: 18632694320803886tt346tt346

18632694320803886tt346
type: Position
type: ExactPosition
position: 346
reference: B2V630-1

18632694320803886tt21
type: Position
type: ExactPosition
position: 21
reference: B2V630-1

18632694320803886tt22
type: Position
type: ExactPosition
position: 22
reference: B2V630-1

18632694320803886tt26
type: Position
type: ExactPosition
position: 26
reference: B2V630-1

18632694320803886tt121
type: Position
type: ExactPosition
position: 121
reference: B2V630-1

18632694320803886tt345
type: Position
type: ExactPosition
position: 345
reference: B2V630-1

18632694320803886tt349
type: Position
type: ExactPosition
position: 349
reference: B2V630-1

18632694320803886tt391
type: Position
type: ExactPosition
position: 391
reference: B2V630-1

B2V630-1
type: Simple Sequence
modified: 2008-07-01
version: 1
mass: 47242
value: MEKTVKKVKRIEGSLRVPSDKSISHRAIILSSLADGTSIVKNFLKAGDTLTTVNAYRKLGVEIVEKEGVYYVHGKGLDGLKEPDDLLDMGNSGTTTRLTLGVLAGFDFFAALTGDDSLRKRPMKRVAEPLSKMGAKIDGRKDGNLLPISIRGGKLTGIDFFNEKMSAQVKSAILLAGLFAKGDTTVIEPVISRDHTENMLNSMGAYVSREFTKDGYRVTVKKADKLNPIHINVPADPSSAAFFAAAASIISGSHIELKDVLINPTRDGFFRKLKEMGAKVEYKNKRDEAGEIVADIYISYHELKGVKVEPQEVPSMIDEIPLLAIIATQAEGETVITGAHELRVKESDRIKSVIENFKRLGLEAEELPDGMIIRGKQKVKGGIVDSYKDHRIAMGFAILGLVSEEGITIKDADCVYISYPEFFNHLEKVSK

http://purl.uniprot.org/uniprot/B2V630#attribution-0A561F4F067256E9CA6406750D5E4A5F
manual: true
evidence: ECO_0000255
source: MF_00210

O66493
type: Protein
reviewed: true
created: 2000-05-30
modified: 2023-09-13
version: 136
mnemonic: AROC_AQUAE
citation: http://purl.uniprot.org/citations/9537320
citation: http://purl.uniprot.org/citations/14705034
recommended name: SIP26EDFBEC82708729
alternative name: SIPE4438FB08936EFF5
enzyme: http://purl.uniprot.org/enzyme/4.2.3.5
organism: http://purl.uniprot.org/taxonomy/224324
annotation: SIP7328D0F10ED3D6DC
annotation: SIPFC6B178A50E62806
annotation: SIP0F5D49278ED7AA29
annotation: SIPE0479A7793C4877C
annotation: SIP02F22E7E69637BD6
annotation: SIP23654D4F8D2C4CEB
annotation: PRO_0000140537
annotation: SIP162807A07B2296C7
annotation: SIP3183C8DE17844D69
annotation: SIPE50A0688B5C79778
annotation: SIP8C282BA6BAD78903
annotation: SIP5271206983BC0777
annotation: SIP1AAE8EA892A93499
annotation: SIP61F517B8F316CA9F
annotation: SIP9378B59F9AD6E67E
annotation: SIP2F0797819601FBBC
annotation: SIP829C08473A9A1EDE
annotation: SIP9558E72C84D40E9A
annotation: SIP140821FA0B9C0069
annotation: SIP99AE446FF9F0EFD7
annotation: SIP866CFEAD67280797
annotation: SIPE2BB0794BE56148E
annotation: SIP8F18A508C654FBFC
annotation: SIP106B266781EA1720
annotation: SIPF1F750D3E6DA1540
annotation: SIP1D8EE57D9581104E
annotation: SIP688C691CBB43CE7F
annotation: SIP7F6C480C55EC1F3D
annotation: SIP22AF4892DEB6368B
annotation: SIPDB16075695CBDED4
annotation: SIP244F85C79558CE34
annotation: SIP25AC77F18356C6D5
annotation: SIP712D0355150BB376
annotation: SIPCAA892941F84EF2E
annotation: SIP71CB50FEEF8D6C3E
annotation: SIP3327806AE19762AF
annotation: SIPC740DE7D499D87D6
annotation: SIP3BC65618DD507EB8
annotation: SIP72E2E736E3A7F8AB
annotation: SIPE4C00719B1F0333B
annotation: SIP42F5DBB7D947CA45
annotation: SIP3B3069443A59E293
annotation: SIP3D6F3996F40635F0
annotation: SIPE311724324F89FB7
annotation: SIPF2CD5F43B073E5A1
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/57
classified with: http://purl.uniprot.org/keywords/274
classified with: http://purl.uniprot.org/keywords/288
classified with: http://purl.uniprot.org/keywords/456
classified with: http://purl.uniprot.org/keywords/521
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005829
classified with: GO_0004107
classified with: GO_0010181
classified with: GO_0008652
classified with: GO_0009073
classified with: GO_0009423
sequence: O66493-1
proteome: Chromosome

O66493-citation-9537320
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

VF5
type: Strain

O66493-citation-14705034
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS)
scope: SUBUNIT

1Q1L
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.05
chain sequence mapping: PDB 1Q1L tt1tt398

PDB 1Q1L tt1tt398
chain: A/B/C/D=1-398

COG0082
type: Resource
database: eggNOG
comment: Bacteria

http://purl.uniprot.org/brenda/4.2.3.5
type: Resource
database: BRENDA
comment: 396

cd07304
type: Resource
database: CDD
comment: Chorismate_synthase
signature sequence match: CDD cd07304 match 1

http://purl.uniprot.org/gene3d/3.60.150.10
type: Resource
database: Gene3D
comment: Chorismate synthase AroC
signature sequence match: Gene3D 3.60.150.10 match 1

MF_00300
type: Resource
database: HAMAP
comment: Chorismate_synth
signature sequence match: HAMAP MF 00300 match 1

IPR000453
type: Resource
database: InterPro
comment: Chorismate_synth

IPR035904
type: Resource
database: InterPro
comment: Chorismate_synth_AroC_sf

IPR020541
type: Resource
database: InterPro
comment: Chorismate_synthase_CS

TIGR00033
type: Resource
database: NCBIfam
comment: aroC
signature sequence match: NCBIfam TIGR00033 match 1

PTHR21085
type: Resource
database: PANTHER
comment: CHORISMATE SYNTHASE
signature sequence match: PANTHER PTHR21085 match 1

PTHR21085:SF0
type: Resource
database: PANTHER
comment: CHORISMATE SYNTHASE
signature sequence match: PANTHER PTHR21085:SF0 match 1

PF01264
type: Resource
database: Pfam
comment: Chorismate_synt
signature sequence match: Pfam PF01264 match 1

PIRSF001456
type: Resource
database: PIRSF
comment: Chorismate_synth
signature sequence match: PIRSF PIRSF001456 match 1

SSF103263
type: Resource
database: SUPFAM
comment: Chorismate synthase, AroC
signature sequence match: SUPFAM SSF103263 match 1

PS00787
type: Resource
database: PROSITE
comment: CHORISMATE_SYNTHASE_1
signature sequence match: PROSITE PS00787 match 1

PS00788
type: Resource
database: PROSITE
comment: CHORISMATE_SYNTHASE_2
signature sequence match: PROSITE PS00788 match 1

SIP26EDFBEC82708729
type: Structured Name
full name: Chorismate synthase
short name: CS
ec name: 4.2.3.5

SIPE4438FB08936EFF5
type: Structured Name
full name: 5-enolpyruvylshikimate-3-phosphate phospholyase

aroC
type: Gene
locus name: aq_081

SIP7328D0F10ED3D6DC
type: Function Annotation
comment: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.

SIP0F5D49278ED7AA29
type: Cofactor Annotation
comment: Reduced FMN (FMNH(2)).
cofactor: CHEBI_57618

SIP02F22E7E69637BD6
type: Subunit Annotation
comment: Homotetramer.

SIP23654D4F8D2C4CEB
type: Similarity Annotation
comment: Belongs to the chorismate synthase family.

PRO_0000140537
type: Chain Annotation
comment: Chorismate synthase
mass: 44254
range: 22296129592439598tt1tt398

22296129592439598tt1
type: Position
type: ExactPosition
position: 1
reference: O66493-1

22296129592439598tt398
type: Position
type: ExactPosition
position: 398
reference: O66493-1

22296129592439598tt44
type: Position
type: ExactPosition
position: 44
reference: O66493-1

22296129592439598tt50
type: Position
type: ExactPosition
position: 50
reference: O66493-1

22296129592439598tt133
type: Position
type: ExactPosition
position: 133
reference: O66493-1

22296129592439598tt135
type: Position
type: ExactPosition
position: 135
reference: O66493-1

22296129592439598tt261
type: Position
type: ExactPosition
position: 261
reference: O66493-1

22296129592439598tt262
type: Position
type: ExactPosition
position: 262
reference: O66493-1

22296129592439598tt306
type: Position
type: ExactPosition
position: 306
reference: O66493-1

22296129592439598tt321
type: Position
type: ExactPosition
position: 321
reference: O66493-1

22296129592439598tt325
type: Position
type: ExactPosition
position: 325
reference: O66493-1

22296129592439598tt347
type: Position
type: ExactPosition
position: 347
reference: O66493-1

22296129592439598tt7
type: Position
type: ExactPosition
position: 7
reference: O66493-1

22296129592439598tt11
type: Position
type: ExactPosition
position: 11
reference: O66493-1

22296129592439598tt16
type: Position
type: ExactPosition
position: 16
reference: O66493-1

22296129592439598tt24
type: Position
type: ExactPosition
position: 24
reference: O66493-1

22296129592439598tt34
type: Position
type: ExactPosition
position: 34
reference: O66493-1

22296129592439598tt45
type: Position
type: ExactPosition
position: 45
reference: O66493-1

22296129592439598tt61
type: Position
type: ExactPosition
position: 61
reference: O66493-1

22296129592439598tt68
type: Position
type: ExactPosition
position: 68
reference: O66493-1

22296129592439598tt77
type: Position
type: ExactPosition
position: 77
reference: O66493-1

22296129592439598tt82
type: Position
type: ExactPosition
position: 82
reference: O66493-1

22296129592439598tt119
type: Position
type: ExactPosition
position: 119
reference: O66493-1

22296129592439598tt123
type: Position
type: ExactPosition
position: 123
reference: O66493-1

22296129592439598tt128
type: Position
type: ExactPosition
position: 128
reference: O66493-1

22296129592439598tt134
type: Position
type: ExactPosition
position: 134
reference: O66493-1

22296129592439598tt136
type: Position
type: ExactPosition
position: 136
reference: O66493-1

22296129592439598tt138
type: Position
type: ExactPosition
position: 138
reference: O66493-1

22296129592439598tt139
type: Position
type: ExactPosition
position: 139
reference: O66493-1

22296129592439598tt154
type: Position
type: ExactPosition
position: 154
reference: O66493-1

22296129592439598tt155
type: Position
type: ExactPosition
position: 155
reference: O66493-1

22296129592439598tt157
type: Position
type: ExactPosition
position: 157
reference: O66493-1

22296129592439598tt159
type: Position
type: ExactPosition
position: 159
reference: O66493-1

22296129592439598tt167
type: Position
type: ExactPosition
position: 167
reference: O66493-1

22296129592439598tt173
type: Position
type: ExactPosition
position: 173
reference: O66493-1

22296129592439598tt175
type: Position
type: ExactPosition
position: 175
reference: O66493-1

22296129592439598tt178
type: Position
type: ExactPosition
position: 178
reference: O66493-1

22296129592439598tt182
type: Position
type: ExactPosition
position: 182
reference: O66493-1

22296129592439598tt184
type: Position
type: ExactPosition
position: 184
reference: O66493-1

22296129592439598tt194
type: Position
type: ExactPosition
position: 194
reference: O66493-1

22296129592439598tt204
type: Position
type: ExactPosition
position: 204
reference: O66493-1

22296129592439598tt206
type: Position
type: ExactPosition
position: 206
reference: O66493-1

22296129592439598tt207
type: Position
type: ExactPosition
position: 207
reference: O66493-1

22296129592439598tt218
type: Position
type: ExactPosition
position: 218
reference: O66493-1

22296129592439598tt219
type: Position
type: ExactPosition
position: 219
reference: O66493-1

22296129592439598tt221
type: Position
type: ExactPosition
position: 221
reference: O66493-1

22296129592439598tt226
type: Position
type: ExactPosition
position: 226
reference: O66493-1

22296129592439598tt234
type: Position
type: ExactPosition
position: 234
reference: O66493-1

22296129592439598tt242
type: Position
type: ExactPosition
position: 242
reference: O66493-1

22296129592439598tt244
type: Position
type: ExactPosition
position: 244
reference: O66493-1

22296129592439598tt245
type: Position
type: ExactPosition
position: 245
reference: O66493-1

22296129592439598tt247
type: Position
type: ExactPosition
position: 247
reference: O66493-1

22296129592439598tt249
type: Position
type: ExactPosition
position: 249
reference: O66493-1

22296129592439598tt258
type: Position
type: ExactPosition
position: 258
reference: O66493-1

22296129592439598tt263
type: Position
type: ExactPosition
position: 263
reference: O66493-1

22296129592439598tt268
type: Position
type: ExactPosition
position: 268
reference: O66493-1

22296129592439598tt271
type: Position
type: ExactPosition
position: 271
reference: O66493-1

22296129592439598tt276
type: Position
type: ExactPosition
position: 276
reference: O66493-1

22296129592439598tt279
type: Position
type: ExactPosition
position: 279
reference: O66493-1

22296129592439598tt281
type: Position
type: ExactPosition
position: 281
reference: O66493-1

22296129592439598tt286
type: Position
type: ExactPosition
position: 286
reference: O66493-1

22296129592439598tt289
type: Position
type: ExactPosition
position: 289
reference: O66493-1

22296129592439598tt290
type: Position
type: ExactPosition
position: 290
reference: O66493-1

22296129592439598tt292
type: Position
type: ExactPosition
position: 292
reference: O66493-1

22296129592439598tt293
type: Position
type: ExactPosition
position: 293
reference: O66493-1

22296129592439598tt297
type: Position
type: ExactPosition
position: 297
reference: O66493-1

22296129592439598tt300
type: Position
type: ExactPosition
position: 300
reference: O66493-1

22296129592439598tt303
type: Position
type: ExactPosition
position: 303
reference: O66493-1

22296129592439598tt314
type: Position
type: ExactPosition
position: 314
reference: O66493-1

22296129592439598tt320
type: Position
type: ExactPosition
position: 320
reference: O66493-1

22296129592439598tt353
type: Position
type: ExactPosition
position: 353
reference: O66493-1

22296129592439598tt376
type: Position
type: ExactPosition
position: 376
reference: O66493-1

22296129592439598tt381
type: Position
type: ExactPosition
position: 381
reference: O66493-1

22296129592439598tt396
type: Position
type: ExactPosition
position: 396
reference: O66493-1

O66493-1
type: Simple Sequence
modified: 1998-08-01
version: 1
mass: 44254
value: MSLRYLRFLTAGESHGKGLTAILEGIPANLPLSEEEINHELRRRQRGYGRGGRMKIEKDTAEILSGVRFGKTLGSPIALFIRNRDWENWKEKMAIEGEPSPSVVPFTRPRPGHADLSGGIKYNQRDLRNILERASARETAARVAVGAVCKKFLSEFGIKIGSFVVSIGQKEVEELKDKSYFANPEKLLSYHEKAEDSELRIPFPEKDEEFKTYIDEVKEKGESLGGVFEVFALNVPPGLGSHIQWDRRIDGRIAQAMMSIQAIKGVEIGLGFEAARRFGSQVHDEIGWSEGKGYFRHSNNLGGTEGGITNGMPIVVRVAMKPIPTLKNPLRSVDIETKEEMKAGKERTDIVAVPAASVVGEAMLAIVLADALLEKLGGDFMEEVKKRFEDYVNHVKSF

http://purl.uniprot.org/uniprot/O66493#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/O66493#attribution-2F3E6EDFAEDDC061C716E49B15F505C7
manual: true
evidence: ECO_0000255
source: MF_00300

http://purl.uniprot.org/uniprot/O66493#attribution-29D320D9AC34478E84D47382E960E92A
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/14705034

B2V7C0
type: Protein
reviewed: true
created: 2009-03-24
modified: 2023-09-13
version: 80
mnemonic: AROC_SULSY
citation: http://purl.uniprot.org/citations/19136599
recommended name: SIP26EDFBEC82708729
alternative name: SIPE4438FB08936EFF5
enzyme: http://purl.uniprot.org/enzyme/4.2.3.5
organism: http://purl.uniprot.org/taxonomy/436114
annotation: SIP5141F17B5394B0F6
annotation: SIP9B3451723AD64D69
annotation: SIPCFEF8F89424E8187
annotation: SIPD6F35FEED4939F66
annotation: SIP3BE5CA24DF2AB40A
annotation: SIP9B36F1FD6EDC8EE0
annotation: PRO_1000115408
annotation: SIP176CEC4CDF186A03
annotation: SIPEF05351B7286AD6C
annotation: SIPDCD18F8C3550EF02
annotation: SIP71B6F2AAF823D903
annotation: SIP227186CD68894C22
annotation: SIPC43FBA689E7D5E61
annotation: SIP092C1DB6055B888B
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/57
classified with: http://purl.uniprot.org/keywords/274
classified with: http://purl.uniprot.org/keywords/288
classified with: http://purl.uniprot.org/keywords/456
classified with: http://purl.uniprot.org/keywords/521
classified with: GO_0004107
classified with: GO_0008652
classified with: GO_0009073
classified with: GO_0009423
sequence: B2V7C0-1

B2V7C0-citation-19136599
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

YO3AOP1
type: Strain

SIP26EDFBEC82708729
type: Structured Name
full name: Chorismate synthase
short name: CS
ec name: 4.2.3.5

SIPE4438FB08936EFF5
type: Structured Name
full name: 5-enolpyruvylshikimate-3-phosphate phospholyase

aroC
type: Gene
locus name: SYO3AOP1_1754

SIP5141F17B5394B0F6
type: Function Annotation
comment: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.

SIPCFEF8F89424E8187
type: Cofactor Annotation
comment: Reduced FMN (FMNH(2)).
cofactor: CHEBI_57618

SIP3BE5CA24DF2AB40A
type: Subunit Annotation
comment: Homotetramer.

SIP9B36F1FD6EDC8EE0
type: Similarity Annotation
comment: Belongs to the chorismate synthase family.

PRO_1000115408
type: Chain Annotation
comment: Chorismate synthase
mass: 43440
range: 18632694338629678tt1tt390

18632694338629678tt1
type: Position
type: ExactPosition
position: 1
reference: B2V7C0-1

18632694338629678tt390
type: Position
type: ExactPosition
position: 390
reference: B2V7C0-1

18632694338629678tt40
type: Position
type: ExactPosition
position: 40
reference: B2V7C0-1

18632694338629678tt46
type: Position
type: ExactPosition
position: 46
reference: B2V7C0-1

18632694338629678tt128
type: Position
type: ExactPosition
position: 128
reference: B2V7C0-1

18632694338629678tt130
type: Position
type: ExactPosition
position: 130
reference: B2V7C0-1

18632694338629678tt251
type: Position
type: ExactPosition
position: 251
reference: B2V7C0-1

18632694338629678tt252
type: Position
type: ExactPosition
position: 252
reference: B2V7C0-1

18632694338629678tt296
type: Position
type: ExactPosition
position: 296
reference: B2V7C0-1

18632694338629678tt311
type: Position
type: ExactPosition
position: 311
reference: B2V7C0-1

18632694338629678tt315
type: Position
type: ExactPosition
position: 315
reference: B2V7C0-1

18632694338629678tt339
type: Position
type: ExactPosition
position: 339
reference: B2V7C0-1

B2V7C0-1
type: Simple Sequence
modified: 2008-07-01
version: 1
mass: 43440
value: MLRFLNAGESHGPALTAIIEGYPSNVKITTDRINKELARRQKGYGRGGRMKIEKDTVEILSGVRFGITLGSPITLVVRNKDWENWTDIMAIEGDSTNKRQILEPRPGHADLTGGIKYGFYDLRNILERASARETTTRVAVGALCKILLEDIGIKIGSYVLSIGEKKIDKSEIESISYEDRFNNAENSELRLPILGKDEEFKEYIDKAKEDGESLGGIFEVYALNVPVGLGSYSQWDTRLDGKIAQAIMSIQAIKGVEIGEGFNLAYLPGSQAHDEIFYSKERGFYRKTNRAGGLEGGMTNGEPIIVRAAMKPIPTLMRHKSLQSVNVITKEPFDAAKERSDITAVPAAAVVAESMLAFVLAREILEKFGSDNWIQIKERIEKYRQDVLNY

http://purl.uniprot.org/uniprot/B2V7C0#attribution-2F3E6EDFAEDDC061C716E49B15F505C7
manual: true
evidence: ECO_0000255
source: MF_00300

O66440
type: Protein
reviewed: true
created: 2000-05-30
modified: 2023-09-13
version: 125
mnemonic: AROD_AQUAE
citation: http://purl.uniprot.org/citations/9537320
citation: http://purl.uniprot.org/citations/23396056
recommended name: SIPDE3A72722C0C56D9
alternative name: SIP1653C78A2D211AC7
alternative name: SIPAFFD25EE9F4D710A
enzyme: http://purl.uniprot.org/enzyme/4.2.1.10
organism: http://purl.uniprot.org/taxonomy/224324
annotation: SIPD0A0E49E31F239E6
annotation: SIPC92B3F3CF69B8AE2
annotation: SIP5F459406D1E89A85
annotation: SIPFF1FEBC922D38E96
annotation: SIP36D8F28EE37C9B15
annotation: PRO_0000138792
annotation: SIPE5E514C8C0309E0A
annotation: SIP3E9025EBC4C6A76C
annotation: SIP9F98445323E9C931
annotation: SIPB034EF5DFF3250DD
annotation: SIPAC65B69FA7E00441
annotation: SIP7C20496F15EC9285
annotation: SIP1DB83AE3ADFDDCB9
annotation: SIPCDF66CAFF0B57C76
annotation: SIP6AE3B73467E45D49
annotation: SIP248FEC3845FEBDB7
annotation: SIPD9FD3B7D7120CC93
annotation: SIP4CEC02E00D2814DB
annotation: SIPA96A46AB884EA881
annotation: SIP297F08073E7D2C36
annotation: SIP757F2941745E2B9D
annotation: SIP04F3AABAD5E6296D
annotation: SIPD8E038D7D1CFA162
annotation: SIP28D1E40FE2456764
annotation: SIP33A97447452EC359
annotation: SIPF43D208D89E22B15
annotation: SIPFF6C70E19AA67558
annotation: SIP91F441F28E9C13A3
annotation: SIPB55F579B90AA3025
annotation: SIP642696CCAC8EEB6C
annotation: SIP93F8A53144F77CC1
annotation: SIP35F398501B68D21F
annotation: SIPAF60C255C367FB9D
annotation: SIP94757131308730AA
annotation: SIPC438701F2F92C145
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/57
classified with: http://purl.uniprot.org/keywords/456
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/704
classified with: GO_0003855
classified with: GO_0046279
classified with: GO_0008652
classified with: GO_0009073
classified with: GO_0009423
sequence: O66440-1
proteome: Chromosome

O66440-citation-9537320
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

VF5
type: Strain

O66440-citation-23396056
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) IN COMPLEX WITH SUBSTRATE ANALOGS
scope: ACTIVE SITE
scope: SUBUNIT

2EGZ
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 1.75
chain sequence mapping: PDB 2EGZ tt1tt219

PDB 2EGZ tt1tt219
chain: A/C=1-219

2YSW
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.25
chain sequence mapping: PDB 2YSW tt1tt219

PDB 2YSW tt1tt219
chain: A/B/C=1-219

COG0710
type: Resource
database: eggNOG
comment: Bacteria

cd00502
type: Resource
database: CDD
comment: DHQase_I
signature sequence match: CDD cd00502 match 1

MF_00214
type: Resource
database: HAMAP
comment: AroD
signature sequence match: HAMAP MF 00214 match 1

IPR018508
type: Resource
database: InterPro
comment: 3-dehydroquinate_DH_AS

IPR001381
type: Resource
database: InterPro
comment: DHquinase_I

TIGR01093
type: Resource
database: NCBIfam
comment: aroD
signature sequence match: NCBIfam TIGR01093 match 1

PTHR43699
type: Resource
database: PANTHER
comment: 3-DEHYDROQUINATE DEHYDRATASE
signature sequence match: PANTHER PTHR43699 match 1

PTHR43699:SF1
type: Resource
database: PANTHER
comment: 3-DEHYDROQUINATE DEHYDRATASE
signature sequence match: PANTHER PTHR43699:SF1 match 1

PF01487
type: Resource
database: Pfam
comment: DHquinase_I
signature sequence match: Pfam PF01487 match 1

PS01028
type: Resource
database: PROSITE
comment: DEHYDROQUINASE_I
signature sequence match: PROSITE PS01028 match 1

SIPDE3A72722C0C56D9
type: Structured Name
full name: 3-dehydroquinate dehydratase
short name: 3-dehydroquinase
ec name: 4.2.1.10

SIP1653C78A2D211AC7
type: Structured Name
full name: Type I DHQase

SIPAFFD25EE9F4D710A
type: Structured Name
full name: Type I dehydroquinase
short name: DHQ1

aroD
type: Gene
locus name: aq_021

SIPD0A0E49E31F239E6
type: Function Annotation
comment: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.

SIPFF1FEBC922D38E96
type: Subunit Annotation
comment: Homodimer.

SIP36D8F28EE37C9B15
type: Similarity Annotation
comment: Belongs to the type-I 3-dehydroquinase family.

PRO_0000138792
type: Chain Annotation
comment: 3-dehydroquinate dehydratase
mass: 24971
range: 22296129592111150tt1tt219

22296129592111150tt1
type: Position
type: ExactPosition
position: 1
reference: O66440-1

22296129592111150tt219
type: Position
type: ExactPosition
position: 219
reference: O66440-1

SIPE5E514C8C0309E0A
type: Active Site Annotation
comment: Proton donor/acceptor
range: 22296129592111150tt116tt116

22296129592111150tt116
type: Position
type: ExactPosition
position: 116
reference: O66440-1

SIP3E9025EBC4C6A76C
type: Active Site Annotation
comment: Schiff-base intermediate with substrate
range: 22296129592111150tt142tt142

22296129592111150tt142
type: Position
type: ExactPosition
position: 142
reference: O66440-1

22296129592111150tt28
type: Position
type: ExactPosition
position: 28
reference: O66440-1

22296129592111150tt30
type: Position
type: ExactPosition
position: 30
reference: O66440-1

22296129592111150tt61
type: Position
type: ExactPosition
position: 61
reference: O66440-1

22296129592111150tt180
type: Position
type: ExactPosition
position: 180
reference: O66440-1

22296129592111150tt203
type: Position
type: ExactPosition
position: 203
reference: O66440-1

22296129592111150tt2
type: Position
type: ExactPosition
position: 2
reference: O66440-1

22296129592111150tt7
type: Position
type: ExactPosition
position: 7
reference: O66440-1

22296129592111150tt12
type: Position
type: ExactPosition
position: 12
reference: O66440-1

22296129592111150tt22
type: Position
type: ExactPosition
position: 22
reference: O66440-1

22296129592111150tt25
type: Position
type: ExactPosition
position: 25
reference: O66440-1

22296129592111150tt31
type: Position
type: ExactPosition
position: 31
reference: O66440-1

22296129592111150tt33
type: Position
type: ExactPosition
position: 33
reference: O66440-1

22296129592111150tt39
type: Position
type: ExactPosition
position: 39
reference: O66440-1

22296129592111150tt51
type: Position
type: ExactPosition
position: 51
reference: O66440-1

22296129592111150tt55
type: Position
type: ExactPosition
position: 55
reference: O66440-1

22296129592111150tt59
type: Position
type: ExactPosition
position: 59
reference: O66440-1

22296129592111150tt63
type: Position
type: ExactPosition
position: 63
reference: O66440-1

22296129592111150tt65
type: Position
type: ExactPosition
position: 65
reference: O66440-1

22296129592111150tt73
type: Position
type: ExactPosition
position: 73
reference: O66440-1

22296129592111150tt80
type: Position
type: ExactPosition
position: 80
reference: O66440-1

22296129592111150tt81
type: Position
type: ExactPosition
position: 81
reference: O66440-1

22296129592111150tt83
type: Position
type: ExactPosition
position: 83
reference: O66440-1

22296129592111150tt84
type: Position
type: ExactPosition
position: 84
reference: O66440-1

22296129592111150tt90
type: Position
type: ExactPosition
position: 90
reference: O66440-1

22296129592111150tt94
type: Position
type: ExactPosition
position: 94
reference: O66440-1

22296129592111150tt96
type: Position
type: ExactPosition
position: 96
reference: O66440-1

22296129592111150tt97
type: Position
type: ExactPosition
position: 97
reference: O66440-1

22296129592111150tt106
type: Position
type: ExactPosition
position: 106
reference: O66440-1

22296129592111150tt110
type: Position
type: ExactPosition
position: 110
reference: O66440-1

22296129592111150tt119
type: Position
type: ExactPosition
position: 119
reference: O66440-1

22296129592111150tt124
type: Position
type: ExactPosition
position: 124
reference: O66440-1

22296129592111150tt136
type: Position
type: ExactPosition
position: 136
reference: O66440-1

22296129592111150tt139
type: Position
type: ExactPosition
position: 139
reference: O66440-1

22296129592111150tt146
type: Position
type: ExactPosition
position: 146
reference: O66440-1

22296129592111150tt150
type: Position
type: ExactPosition
position: 150
reference: O66440-1

22296129592111150tt160
type: Position
type: ExactPosition
position: 160
reference: O66440-1

22296129592111150tt167
type: Position
type: ExactPosition
position: 167
reference: O66440-1

22296129592111150tt174
type: Position
type: ExactPosition
position: 174
reference: O66440-1

22296129592111150tt175
type: Position
type: ExactPosition
position: 175
reference: O66440-1

22296129592111150tt178
type: Position
type: ExactPosition
position: 178
reference: O66440-1

22296129592111150tt179
type: Position
type: ExactPosition
position: 179
reference: O66440-1

22296129592111150tt182
type: Position
type: ExactPosition
position: 182
reference: O66440-1

22296129592111150tt183
type: Position
type: ExactPosition
position: 183
reference: O66440-1

22296129592111150tt186
type: Position
type: ExactPosition
position: 186
reference: O66440-1

22296129592111150tt190
type: Position
type: ExactPosition
position: 190
reference: O66440-1

22296129592111150tt192
type: Position
type: ExactPosition
position: 192
reference: O66440-1

22296129592111150tt194
type: Position
type: ExactPosition
position: 194
reference: O66440-1

22296129592111150tt197
type: Position
type: ExactPosition
position: 197
reference: O66440-1

22296129592111150tt206
type: Position
type: ExactPosition
position: 206
reference: O66440-1

22296129592111150tt216
type: Position
type: ExactPosition
position: 216
reference: O66440-1

O66440-1
type: Simple Sequence
modified: 1998-08-01
version: 1
mass: 24971
value: MLIAVPLDDTNFSENLKKAKEKGADIVELRVDQFSDTSLNYVKEKLEEVHSQGLKTILTIRSPEEGGREVKNREELFEELSPLSDYTDIELSSRGLLVKLYNITKEAGKKLIISYHNFELTPPNWIIREVLREGYRYGGIPKIAVKANSYEDVARLLCISRQVEGEKILISMGDYGKISRLAGYVFGSVITYCSLEKAFAPGQIPLEEMVELRKKFYRL

http://purl.uniprot.org/uniprot/O66440#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/O66440#attribution-AA5D28B8D6D44CA4EFA21F42BFC7C935
manual: true
evidence: ECO_0000255
source: MF_00214

http://purl.uniprot.org/uniprot/O66440#attribution-D134132D7FF8B619C5AE42B39166ED3B
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/23396056

B4U701
type: Protein
reviewed: true
created: 2009-03-24
modified: 2023-09-13
version: 74
mnemonic: AROD_HYDS0
citation: http://purl.uniprot.org/citations/19136599
recommended name: SIPDE3A72722C0C56D9
alternative name: SIP1653C78A2D211AC7
alternative name: SIPAFFD25EE9F4D710A
enzyme: http://purl.uniprot.org/enzyme/4.2.1.10
organism: http://purl.uniprot.org/taxonomy/380749
annotation: SIP7F75EAA2CE4AB6A4
annotation: SIPC15F15BB9B78C257
annotation: SIP936336BFAC956D75
annotation: SIPF74938A1F6AC7262
annotation: SIPB240BAD235D6E459
annotation: PRO_1000099908
annotation: SIP3C36C6267EBF1406
annotation: SIP656DCDC9F919D0C7
annotation: SIPC7A18DCB57743ADC
annotation: SIPA17160DF4ABFD336
annotation: SIPEA57C8BEC2592D90
annotation: SIPD3EF4A02F5A2B1A6
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/57
classified with: http://purl.uniprot.org/keywords/456
classified with: http://purl.uniprot.org/keywords/704
classified with: GO_0003855
classified with: GO_0046279
classified with: GO_0008652
classified with: GO_0009073
classified with: GO_0009423
sequence: B4U701-1

B4U701-citation-19136599
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

Y04AAS1
type: Strain

SIPDE3A72722C0C56D9
type: Structured Name
full name: 3-dehydroquinate dehydratase
short name: 3-dehydroquinase
ec name: 4.2.1.10

SIP1653C78A2D211AC7
type: Structured Name
full name: Type I DHQase

SIPAFFD25EE9F4D710A
type: Structured Name
full name: Type I dehydroquinase
short name: DHQ1

aroD
type: Gene
locus name: HY04AAS1_0220

SIP7F75EAA2CE4AB6A4
type: Function Annotation
comment: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.

SIPF74938A1F6AC7262
type: Subunit Annotation
comment: Homodimer.

SIPB240BAD235D6E459
type: Similarity Annotation
comment: Belongs to the type-I 3-dehydroquinase family.

PRO_1000099908
type: Chain Annotation
comment: 3-dehydroquinate dehydratase
mass: 24817
range: 18634889065673006tt1tt217

18634889065673006tt1
type: Position
type: ExactPosition
position: 1
reference: B4U701-1

18634889065673006tt217
type: Position
type: ExactPosition
position: 217
reference: B4U701-1

SIP3C36C6267EBF1406
type: Active Site Annotation
comment: Proton donor/acceptor
range: 18634889065673006tt114tt114

18634889065673006tt114
type: Position
type: ExactPosition
position: 114
reference: B4U701-1

SIP656DCDC9F919D0C7
type: Active Site Annotation
comment: Schiff-base intermediate with substrate
range: 18634889065673006tt140tt140

18634889065673006tt140
type: Position
type: ExactPosition
position: 140
reference: B4U701-1

18634889065673006tt26
type: Position
type: ExactPosition
position: 26
reference: B4U701-1

18634889065673006tt28
type: Position
type: ExactPosition
position: 28
reference: B4U701-1

18634889065673006tt59
type: Position
type: ExactPosition
position: 59
reference: B4U701-1

18634889065673006tt178
type: Position
type: ExactPosition
position: 178
reference: B4U701-1

18634889065673006tt201
type: Position
type: ExactPosition
position: 201
reference: B4U701-1

B4U701-1
type: Simple Sequence
modified: 2008-09-23
version: 1
mass: 24817
value: MKIAIPITDENFDEVLLKARNADILEFRVDSFTNKDISFVSGLLKKAKENGFETILTIRSEKEGGAYVENRVEMFEKLMPLSDYTDIELSSTDIIAYISRLSKEYNKKLIVSYHNFEMTPANFVIKETIREALRYGDIPKIALKANSYEDVARLMCSAIDIKTPKILISMGEFGKISRIAGFIFGSFISYAYLEKPNAPGQLSLEEMLKLKEMFYLR

http://purl.uniprot.org/uniprot/B4U701#attribution-AA5D28B8D6D44CA4EFA21F42BFC7C935
manual: true
evidence: ECO_0000255
source: MF_00214

O67049
type: Protein
reviewed: true
created: 2000-12-01
modified: 2023-09-13
version: 145
mnemonic: AROE_AQUAE
citation: http://purl.uniprot.org/citations/9537320
citation: http://purl.uniprot.org/citations/17649975
recommended name: SIP8EC2BDE2146DC96B
enzyme: http://purl.uniprot.org/enzyme/1.1.1.25
organism: http://purl.uniprot.org/taxonomy/224324
annotation: SIPB9E7ECD10A3E9A04
annotation: SIPBE5FEBF26F4F43DB
annotation: SIP9A2FB3962902A250
annotation: SIP1FA9C8232162FA6D
annotation: SIP199DBA4ECA5DA8DD
annotation: SIP8618C6384AADC5BB
annotation: SIP55A5B740E70F051A
annotation: PRO_0000135990
annotation: SIP187D776ECE8685B6
annotation: SIP5F267732BD3B39D9
annotation: SIPE498C43ACACD8C7C
annotation: SIP9112A9FD51B10E79
annotation: SIP0B1C530F646B35D8
annotation: SIPAD3DBD648C23D6C5
annotation: SIP77C63CAEEFAD5A16
annotation: SIP7911BF82F37E4A80
annotation: SIPBD27FFFAD938B979
annotation: SIP70367053A94CE1C7
annotation: SIP56B9B0486A2D1E1B
annotation: SIP03B6AB4DD2E61A27
annotation: SIPCBC6A6CC3F3C814A
annotation: SIP2DF0FAA2A689E272
annotation: SIP18554456467E10FB
annotation: SIP80183DF5231448B2
annotation: SIP946A496645D1662A
annotation: SIP5723AC035FB22F3F
annotation: SIP3401E00BD181D96A
annotation: SIPD5E9B9959DCBCA96
annotation: SIP53A65C2E8510D3CA
annotation: SIP9A737CA4DC7DDF49
annotation: SIP5AF84973C87EA598
annotation: SIP4FFB7940B311801B
annotation: SIPA2DD4BDA81C3C342
annotation: SIP50C47FB20C070262
annotation: SIP49DF1702162F1A7B
annotation: SIP5889D0FA38986281
annotation: SIP0ED960B97606EC73
annotation: SIPAC2B64199B1A92E2
annotation: SIP4ECBB053E59E5E0E
annotation: SIP40FD6298BAD455B6
annotation: SIP24FA9BDCDA583E44
annotation: SIPF02B005F1C92D02C
annotation: SIPD7980C5820E2F410
annotation: SIPFAA25457DB4DFD97
annotation: SIP02D5AF837EB21282
annotation: SIPCF1F91A1F0A8CB39
annotation: SIPA2B1944B2B8AA6BE
annotation: SIP7DAEBEC5868A7475
annotation: SIP67728E96492F903F
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/57
classified with: http://purl.uniprot.org/keywords/521
classified with: http://purl.uniprot.org/keywords/560
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005829
classified with: GO_0050661
classified with: GO_0004764
classified with: GO_0008652
classified with: GO_0009073
classified with: GO_0009423
classified with: GO_0019632
sequence: O67049-1
proteome: Chromosome

O67049-citation-9537320
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

VF5
type: Strain

O67049-citation-17649975
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) IN COMPLEX WITH SHIKIMATE AND NADP
scope: FUNCTION
scope: CATALYTIC ACTIVITY
scope: BIOPHYSICOCHEMICAL PROPERTIES
scope: ACTIVE SITE
scope: REACTION MECHANISM
scope: SUBUNIT

2HK7
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.50
chain sequence mapping: PDB 2HK7 tt1tt269

PDB 2HK7 tt1tt269
chain: A/B=1-269

2HK8
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.35
chain sequence mapping: PDB 2HK8 tt1tt269

PDB 2HK8 tt1tt269
chain: A/B/C/D/E/F/G/H=1-269

2HK9
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.20
chain sequence mapping: PDB 2HK9 tt1tt269

PDB 2HK9 tt1tt269
chain: A/B/C/D=1-269

COG0169
type: Resource
database: eggNOG
comment: Bacteria

http://purl.uniprot.org/brenda/1.1.1.25
type: Resource
database: BRENDA
comment: 396

cd01065
type: Resource
database: CDD
comment: NAD_bind_Shikimate_DH
signature sequence match: CDD cd01065 match 1

http://purl.uniprot.org/gene3d/3.40.50.10860
type: Resource
database: Gene3D
comment: Leucine Dehydrogenase, chain A, domain 1
signature sequence match: Gene3D 3.40.50.10860 match 1

MF_00222
type: Resource
database: HAMAP
comment: Shikimate_DH_AroE
signature sequence match: HAMAP MF 00222 match 1

IPR046346
type: Resource
database: InterPro
comment: Aminoacid_DH-like_N_sf

IPR041121
type: Resource
database: InterPro
comment: SDH_C

IPR011342
type: Resource
database: InterPro
comment: Shikimate_DH

IPR013708
type: Resource
database: InterPro
comment: Shikimate_DH-bd_N

IPR022893
type: Resource
database: InterPro
comment: Shikimate_DH_fam

IPR006151
type: Resource
database: InterPro
comment: Shikm_DH/Glu-tRNA_Rdtase

TIGR00507
type: Resource
database: NCBIfam
comment: aroE
signature sequence match: NCBIfam TIGR00507 match 1

PTHR21089:SF1
type: Resource
database: PANTHER
comment: BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE/SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC
signature sequence match: PANTHER PTHR21089:SF1 match 1

PTHR21089
type: Resource
database: PANTHER
comment: SHIKIMATE DEHYDROGENASE
signature sequence match: PANTHER PTHR21089 match 1

PF18317
type: Resource
database: Pfam
comment: SDH_C
signature sequence match: Pfam PF18317 match 1

PF01488
type: Resource
database: Pfam
comment: Shikimate_DH
signature sequence match: Pfam PF01488 match 1

PF08501
type: Resource
database: Pfam
comment: Shikimate_dh_N
signature sequence match: Pfam PF08501 match 1

SSF53223
type: Resource
database: SUPFAM
comment: Aminoacid dehydrogenase-like, N-terminal domain
signature sequence match: SUPFAM SSF53223 match 1

SIP8EC2BDE2146DC96B
type: Structured Name
full name: Shikimate dehydrogenase (NADP(+))
short name: SD
short name: SDH
ec name: 1.1.1.25

aroE
type: Gene
locus name: aq_901

SIPB9E7ECD10A3E9A04
type: Function Annotation
comment: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

SIP9A2FB3962902A250
type: Kinetics Annotation
comment: kcat is 55.5 sec(-1) for dehydrogenase activity (at pH 9 and 25 degrees Celsius).
measured affinity: 42.4 uM for shikimate (at pH 9 and 25 degrees Celsius)
measured affinity: 42.4 uM for NADP (at pH 9 and 25 degrees Celsius)

SIP199DBA4ECA5DA8DD
type: Subunit Annotation
comment: Homodimer.

SIP8618C6384AADC5BB
type: Annotation
comment: AroE is dependent on the hydrogen ion concentration of the environment. A low pH environment favors the formation of SA and NADP, whereas a high pH condition favors the formation of DHSA and NADPH.

SIP55A5B740E70F051A
type: Similarity Annotation
comment: Belongs to the shikimate dehydrogenase family.

PRO_0000135990
type: Chain Annotation
comment: Shikimate dehydrogenase (NADP(+))
mass: 30106
range: 22296133819971886tt1tt269

22296133819971886tt1
type: Position
type: ExactPosition
position: 1
reference: O67049-1

22296133819971886tt269
type: Position
type: ExactPosition
position: 269
reference: O67049-1

SIP187D776ECE8685B6
type: Active Site Annotation
comment: Proton acceptor
range: 22296133819971886tt70tt70

22296133819971886tt70
type: Position
type: ExactPosition
position: 70
reference: O67049-1

22296133819971886tt19
type: Position
type: ExactPosition
position: 19
reference: O67049-1

22296133819971886tt21
type: Position
type: ExactPosition
position: 21
reference: O67049-1

22296133819971886tt66
type: Position
type: ExactPosition
position: 66
reference: O67049-1

22296133819971886tt82
type: Position
type: ExactPosition
position: 82
reference: O67049-1

22296133819971886tt91
type: Position
type: ExactPosition
position: 91
reference: O67049-1

22296133819971886tt106
type: Position
type: ExactPosition
position: 106
reference: O67049-1

22296133819971886tt130
type: Position
type: ExactPosition
position: 130
reference: O67049-1

22296133819971886tt134
type: Position
type: ExactPosition
position: 134
reference: O67049-1

22296133819971886tt153
type: Position
type: ExactPosition
position: 153
reference: O67049-1

22296133819971886tt158
type: Position
type: ExactPosition
position: 158
reference: O67049-1

22296133819971886tt214
type: Position
type: ExactPosition
position: 214
reference: O67049-1

22296133819971886tt216
type: Position
type: ExactPosition
position: 216
reference: O67049-1

22296133819971886tt235
type: Position
type: ExactPosition
position: 235
reference: O67049-1

22296133819971886tt242
type: Position
type: ExactPosition
position: 242
reference: O67049-1

22296133819971886tt7
type: Position
type: ExactPosition
position: 7
reference: O67049-1

22296133819971886tt15
type: Position
type: ExactPosition
position: 15
reference: O67049-1

22296133819971886tt32
type: Position
type: ExactPosition
position: 32
reference: O67049-1

22296133819971886tt35
type: Position
type: ExactPosition
position: 35
reference: O67049-1

22296133819971886tt42
type: Position
type: ExactPosition
position: 42
reference: O67049-1

22296133819971886tt45
type: Position
type: ExactPosition
position: 45
reference: O67049-1

22296133819971886tt47
type: Position
type: ExactPosition
position: 47
reference: O67049-1

22296133819971886tt48
type: Position
type: ExactPosition
position: 48
reference: O67049-1

22296133819971886tt58
type: Position
type: ExactPosition
position: 58
reference: O67049-1

22296133819971886tt62
type: Position
type: ExactPosition
position: 62
reference: O67049-1

22296133819971886tt65
type: Position
type: ExactPosition
position: 65
reference: O67049-1

22296133819971886tt73
type: Position
type: ExactPosition
position: 73
reference: O67049-1

22296133819971886tt74
type: Position
type: ExactPosition
position: 74
reference: O67049-1

22296133819971886tt76
type: Position
type: ExactPosition
position: 76
reference: O67049-1

22296133819971886tt78
type: Position
type: ExactPosition
position: 78
reference: O67049-1

22296133819971886tt80
type: Position
type: ExactPosition
position: 80
reference: O67049-1

22296133819971886tt87
type: Position
type: ExactPosition
position: 87
reference: O67049-1

22296133819971886tt92
type: Position
type: ExactPosition
position: 92
reference: O67049-1

22296133819971886tt96
type: Position
type: ExactPosition
position: 96
reference: O67049-1

22296133819971886tt99
type: Position
type: ExactPosition
position: 99
reference: O67049-1

22296133819971886tt103
type: Position
type: ExactPosition
position: 103
reference: O67049-1

22296133819971886tt117
type: Position
type: ExactPosition
position: 117
reference: O67049-1

22296133819971886tt121
type: Position
type: ExactPosition
position: 121
reference: O67049-1

22296133819971886tt123
type: Position
type: ExactPosition
position: 123
reference: O67049-1

22296133819971886tt124
type: Position
type: ExactPosition
position: 124
reference: O67049-1

22296133819971886tt129
type: Position
type: ExactPosition
position: 129
reference: O67049-1

22296133819971886tt133
type: Position
type: ExactPosition
position: 133
reference: O67049-1

22296133819971886tt145
type: Position
type: ExactPosition
position: 145
reference: O67049-1

22296133819971886tt148
type: Position
type: ExactPosition
position: 148
reference: O67049-1

22296133819971886tt152
type: Position
type: ExactPosition
position: 152
reference: O67049-1

22296133819971886tt156
type: Position
type: ExactPosition
position: 156
reference: O67049-1

22296133819971886tt162
type: Position
type: ExactPosition
position: 162
reference: O67049-1

22296133819971886tt163
type: Position
type: ExactPosition
position: 163
reference: O67049-1

22296133819971886tt165
type: Position
type: ExactPosition
position: 165
reference: O67049-1

22296133819971886tt168
type: Position
type: ExactPosition
position: 168
reference: O67049-1

22296133819971886tt170
type: Position
type: ExactPosition
position: 170
reference: O67049-1

22296133819971886tt174
type: Position
type: ExactPosition
position: 174
reference: O67049-1

22296133819971886tt176
type: Position
type: ExactPosition
position: 176
reference: O67049-1

22296133819971886tt178
type: Position
type: ExactPosition
position: 178
reference: O67049-1

22296133819971886tt180
type: Position
type: ExactPosition
position: 180
reference: O67049-1

22296133819971886tt182
type: Position
type: ExactPosition
position: 182
reference: O67049-1

22296133819971886tt186
type: Position
type: ExactPosition
position: 186
reference: O67049-1

22296133819971886tt202
type: Position
type: ExactPosition
position: 202
reference: O67049-1

22296133819971886tt204
type: Position
type: ExactPosition
position: 204
reference: O67049-1

22296133819971886tt209
type: Position
type: ExactPosition
position: 209
reference: O67049-1

22296133819971886tt217
type: Position
type: ExactPosition
position: 217
reference: O67049-1

22296133819971886tt220
type: Position
type: ExactPosition
position: 220
reference: O67049-1

22296133819971886tt227
type: Position
type: ExactPosition
position: 227
reference: O67049-1

22296133819971886tt231
type: Position
type: ExactPosition
position: 231
reference: O67049-1

22296133819971886tt233
type: Position
type: ExactPosition
position: 233
reference: O67049-1

22296133819971886tt236
type: Position
type: ExactPosition
position: 236
reference: O67049-1

22296133819971886tt251
type: Position
type: ExactPosition
position: 251
reference: O67049-1

22296133819971886tt257
type: Position
type: ExactPosition
position: 257
reference: O67049-1

22296133819971886tt268
type: Position
type: ExactPosition
position: 268
reference: O67049-1

O67049-1
type: Simple Sequence
modified: 1998-08-01
version: 1
mass: 30106
value: MINAQTQLYGVIGFPVKHSLSPVFQNALIRYAGLNAVYLAFEINPEELKKAFEGFKALKVKGINVTVPFKEEIIPLLDYVEDTAKEIGAVNTVKFENGKAYGYNTDWIGFLKSLKSLIPEVKEKSILVLGAGGASRAVIYALVKEGAKVFLWNRTKEKAIKLAQKFPLEVVNSPEEVIDKVQVIVNTTSVGLKDKDPEIFNYDLIKKDHVVVDIIYKETKLLKKAKEKGAKLFDGLPMLLWQGIEAFKIWNGCEVPYSVAERSVRDLRG

http://purl.uniprot.org/uniprot/O67049#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/O67049#attribution-CE1CFCD7F98255636B811CD0B339D974
creator: UniProtKB
manual: true
evidence: ECO_0000314
source: http://purl.uniprot.org/citations/17649975

http://purl.uniprot.org/uniprot/O67049#attribution-5C7F524C16633F113A12ABC5480D4824
manual: true
evidence: ECO_0000255
source: MF_00222

http://purl.uniprot.org/uniprot/O67049#attribution-1AE324BCAC8EE778A54105AD69EA9BCE
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/17649975

http://purl.uniprot.org/uniprot/O67049#attribution-1459717E9C118127977F4979D9CC3329
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/17649975

http://purl.uniprot.org/uniprot/O67049#attribution-6F16B212B77BA0A83E42F2A4461B79EB
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/17649975

O67925
type: Protein
reviewed: true
created: 2000-05-30
modified: 2023-06-28
version: 125
mnemonic: AROK_AQUAE
citation: http://purl.uniprot.org/citations/9537320
citation: SIP37E3DB27CA4F82EE
recommended name: SIP6918AA3D5BEFE474
enzyme: http://purl.uniprot.org/enzyme/2.7.1.71
organism: http://purl.uniprot.org/taxonomy/224324
annotation: SIPC634CEBD76C89CA1
annotation: SIP5F0C781DDDBBE8AA
annotation: SIP98640AED61B023D5
annotation: SIP8205D1E041BAFF5B
annotation: SIP4C0B2B44C8ACA820
annotation: SIP18FF7C5BA0DD1BC4
annotation: SIP411CCF85087363F4
annotation: PRO_0000192366
annotation: SIP88986EAA8820FCDC
annotation: SIPCEE94872F69EB607
annotation: SIPE25D8A8E3848E10F
annotation: SIP4A0311643D8F8678
annotation: SIPDC3F7B0043A5C608
annotation: SIPAA3D15CD116334E0
annotation: SIP6C009DB8A55EB03A
annotation: SIPC0EE120BC89C70AC
annotation: SIP2595F74656D32828
annotation: SIPF953F13F57C4C286
annotation: SIPFB8A4F9F5E8539C1
annotation: SIP63B5A1BACDE6297F
annotation: SIP14D3CEE51A65BED4
annotation: SIPCD028F0683E23B1B
annotation: SIP9BFEBBD1FE28D9AE
annotation: SIPCAEB6ABC0F7E38BB
annotation: SIP3A38EFCBEE6D1987
annotation: SIP4D75A3F0F2446CC8
annotation: SIP9FC171762ACB61A1
annotation: SIP5E05771FF5830F07
annotation: SIP2608294272B58764
annotation: SIPF563AB956E4771E4
annotation: SIPE8169E597FCA7ACF
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/57
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/418
classified with: http://purl.uniprot.org/keywords/460
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005829
classified with: GO_0005524
classified with: GO_0000287
classified with: GO_0004765
classified with: GO_0008652
classified with: GO_0009073
classified with: GO_0009423
classified with: GO_0016310
sequence: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG
proteome: Chromosome

O67925-citation-9537320
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

VF5
type: Strain

SIP37E3DB27CA4F82EE
type: Submission Citation
title: Crystal structure of shikimate kinase (aq_2177) from Aquifex aeolicus VF5.
group: RIKEN structural genomics initiative (RSGI)
date: 2008-05
submitted to: PDB

O67925-citation-SIP37E3DB27CA4F82EE
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS)

2PT5
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.10
chain sequence mapping: PDB 2PT5 tt1tt168

PDB 2PT5 tt1tt168
chain: A/B/C/D=1-168

COG0703
type: Resource
database: eggNOG
comment: Bacteria

cd00464
type: Resource
database: CDD
comment: SK
signature sequence match: CDD cd00464 match 1

MF_00109
type: Resource
database: HAMAP
comment: Shikimate_kinase
signature sequence match: HAMAP MF 00109 match 1

IPR031322
type: Resource
database: InterPro
comment: Shikimate/glucono_kinase

IPR000623
type: Resource
database: InterPro
comment: Shikimate_kinase/TSH1

IPR023000
type: Resource
database: InterPro
comment: Shikimate_kinase_CS

PTHR21087
type: Resource
database: PANTHER
comment: SHIKIMATE KINASE
signature sequence match: PANTHER PTHR21087 match 1

PTHR21087:SF16
type: Resource
database: PANTHER
comment: SHIKIMATE KINASE 1, CHLOROPLASTIC
signature sequence match: PANTHER PTHR21087:SF16 match 1

PF01202
type: Resource
database: Pfam
comment: SKI
signature sequence match: Pfam PF01202 match 1

PR01100
type: Resource
database: PRINTS
comment: SHIKIMTKNASE

PS01128
type: Resource
database: PROSITE
comment: SHIKIMATE_KINASE
signature sequence match: PROSITE PS01128 match 1

SIP6918AA3D5BEFE474
type: Structured Name
full name: Shikimate kinase
short name: SK
ec name: 2.7.1.71

aroK
type: Gene
locus name: aq_2177

SIPC634CEBD76C89CA1
type: Function Annotation
comment: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.

SIP98640AED61B023D5
type: Cofactor Annotation
comment: Binds 1 Mg(2+) ion per subunit.
cofactor: CHEBI_18420

SIP4C0B2B44C8ACA820
type: Subunit Annotation
comment: Monomer.

SIP411CCF85087363F4
type: Similarity Annotation
comment: Belongs to the shikimate kinase family.

PRO_0000192366
type: Chain Annotation
comment: Shikimate kinase
mass: 19080
range: 22296133970834734tt1tt168

22296133970834734tt1
type: Position
type: ExactPosition
position: 1
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt168
type: Position
type: ExactPosition
position: 168
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt10
type: Position
type: ExactPosition
position: 10
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt15
type: Position
type: ExactPosition
position: 15
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt14
type: Position
type: ExactPosition
position: 14
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt32
type: Position
type: ExactPosition
position: 32
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt56
type: Position
type: ExactPosition
position: 56
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt78
type: Position
type: ExactPosition
position: 78
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt116
type: Position
type: ExactPosition
position: 116
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt133
type: Position
type: ExactPosition
position: 133
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt2
type: Position
type: ExactPosition
position: 2
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt7
type: Position
type: ExactPosition
position: 7
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt13
type: Position
type: ExactPosition
position: 13
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt24
type: Position
type: ExactPosition
position: 24
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt28
type: Position
type: ExactPosition
position: 28
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt30
type: Position
type: ExactPosition
position: 30
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt31
type: Position
type: ExactPosition
position: 31
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt39
type: Position
type: ExactPosition
position: 39
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt43
type: Position
type: ExactPosition
position: 43
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt49
type: Position
type: ExactPosition
position: 49
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt52
type: Position
type: ExactPosition
position: 52
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt66
type: Position
type: ExactPosition
position: 66
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt69
type: Position
type: ExactPosition
position: 69
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt75
type: Position
type: ExactPosition
position: 75
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt81
type: Position
type: ExactPosition
position: 81
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt84
type: Position
type: ExactPosition
position: 84
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt91
type: Position
type: ExactPosition
position: 91
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt94
type: Position
type: ExactPosition
position: 94
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt100
type: Position
type: ExactPosition
position: 100
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt103
type: Position
type: ExactPosition
position: 103
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt109
type: Position
type: ExactPosition
position: 109
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt118
type: Position
type: ExactPosition
position: 118
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt120
type: Position
type: ExactPosition
position: 120
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt123
type: Position
type: ExactPosition
position: 123
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt125
type: Position
type: ExactPosition
position: 125
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt127
type: Position
type: ExactPosition
position: 127
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt137
type: Position
type: ExactPosition
position: 137
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt140
type: Position
type: ExactPosition
position: 140
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt145
type: Position
type: ExactPosition
position: 145
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt150
type: Position
type: ExactPosition
position: 150
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

22296133970834734tt162
type: Position
type: ExactPosition
position: 162
reference: MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG

substrate

MRIYLIGFMCSGKSTVGSLLSRSLNIPFYDVDEEVQKREGLSIPQIFEKKGEAYFRKLEFEVLKDLSEKENVVISTGGGLGANEEALNFMKSRGTTVFIDIPFEVFLERCKDSKERPLLKRPLDEIKNLFEERRKIYSKADIKVKGEKPPEEVVKEILLSLEGNALGG
type: Simple Sequence
modified: 1998-08-01
version: 1
mass: 19080

http://purl.uniprot.org/uniprot/O67925#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/O67925#attribution-721B6DCFEBB6A97B07CF9A0173E141ED
manual: true
evidence: ECO_0000255
source: MF_00109

C0QR76
type: Protein
reviewed: true
created: 2009-07-28
modified: 2023-06-28
version: 68
mnemonic: AROK_PERMH
citation: http://purl.uniprot.org/citations/19136599
recommended name: SIP6918AA3D5BEFE474
enzyme: http://purl.uniprot.org/enzyme/2.7.1.71
organism: http://purl.uniprot.org/taxonomy/123214
annotation: SIP70EFD0FEF2EED753
annotation: SIP77F66E48A94406EC
annotation: SIP61714D1AC58FC96E
annotation: SIP42F36EE8F36C5E5F
annotation: SIPF2839798732729AA
annotation: SIP39833FA1C90FC8C3
annotation: SIP4C85888F6DFBA883
annotation: PRO_1000119061
annotation: SIP5968AA08A8C650E1
annotation: SIPD70C4A0869718195
annotation: SIP555FE4F358A55498
annotation: SIP2FF722EF44BE00FA
annotation: SIP2766A1CA2C3C2A96
annotation: SIP30C0E13AA15D85AF
annotation: SIP0130A1CFCE7AEF61
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/57
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/418
classified with: http://purl.uniprot.org/keywords/460
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005737
classified with: GO_0005524
classified with: GO_0000287
classified with: GO_0004765
classified with: GO_0008652
classified with: GO_0009073
classified with: GO_0009423
classified with: GO_0016310
sequence: C0QR76-1
proteome: Chromosome

C0QR76-citation-19136599
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

DSM 14350 / EX-H1
type: Strain

SIP6918AA3D5BEFE474
type: Structured Name
full name: Shikimate kinase
short name: SK
ec name: 2.7.1.71

aroK
type: Gene
locus name: PERMA_1404

SIP70EFD0FEF2EED753
type: Function Annotation
comment: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.

SIP61714D1AC58FC96E
type: Cofactor Annotation
comment: Binds 1 Mg(2+) ion per subunit.
cofactor: CHEBI_18420