J9ZXD8
type: Protein
reviewed: true
created: 2020-08-12
modified: 2023-09-13
version: 19
mnemonic: PROT_BACS1
citation: http://purl.uniprot.org/citations/22983711
recommended name: SIP91C0EA046DC28A8E
alternative name: SIP50449BBF388296E7
organism: http://purl.uniprot.org/taxonomy/1221190
annotation: SIPA81418AFD587FB78
annotation: SIPC5B60DA08BEB2F93
annotation: SIP87FD4491E2276861
annotation: SIP8B11751368EEE518
annotation: SIP56854E68C4365721
annotation: SIPE7ED0A45C2775042
annotation: PRO_0000450586
annotation: PRO_0000450587
annotation: SIP5077ECEB1C6B6E1B
annotation: SIP0A44D9199156773C
annotation: SIP451E3E91E288CCBA
annotation: SIPD3F0AF7207378C69
annotation: SIPF639FC483471CEA9
annotation: SIPC1C58A5F7C13AD1D
annotation: SIP496738436404EEEC
annotation: SIP24661210E1C2F690
annotation: SIPE43867C0DF912D4C
annotation: SIP42CEBFF7537044DA
annotation: SIP4B014A9D0160E942
annotation: SIP7FA356F604D40240
annotation: SIP641F97B78BB265D1
annotation: SIP967AE5BD37B1C6DF
annotation: SIP4B1942D83BEFBA17
annotation: SIP66E91557493AD028
annotation: SIP4352D68C47249293
annotation: SIP5135A45DC5829E02
annotation: SIP7D317315E4784D89
annotation: SIPE3E6D6C0E089504E
annotation: SIP396019EED6638AE5
annotation: SIPA5D14B45260105D6
annotation: SIPDCA38475176928AF
annotation: SIPF0097EBE8BA7421B
annotation: SIP82A891AF685B9B4D
annotation: SIP5FD02CC6B79F245A
annotation: SIP85270499473C57BE
annotation: SIP1225A1CCF82E8ACB
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/44
classified with: http://purl.uniprot.org/keywords/208
classified with: http://purl.uniprot.org/keywords/379
classified with: http://purl.uniprot.org/keywords/488
classified with: GO_0003824
classified with: GO_0046914
classified with: GO_0042742
classified with: GO_0006807
sequence: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

J9ZXD8-citation-22983711
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: EXPRESSION IN E.COLI
scope: D-AMINO ACID AT VAL-102; ALA-104; VAL-106; VAL-110; ASN-112; ASN-118; VAL-120; ASN-124; ASN-126; VAL-128; ASN-130; ASN-132; ASN-134; ASN-136; SER-138; ASN-140; ASN-142 AND THR-144
scope: METHYLATION AT ILE-99; VAL-101; VAL-102; VAL-103; VAL-105; VAL-106; VAL-110; ASN-112; THR-113; VAL-117; ASN-118; GLN-119; ASN-124; ASN-126; VAL-127; ASN-130; ASN-132; ASN-134; ASN-136 AND MET-141
scope: HYDROXYLATION AT VAL-120; ASN-126; VAL-128 AND ASN-134

1.D.24.1.1
type: Resource
database: TCDB
comment: the marine sponge polytheonamide b (ptb) family

http://purl.uniprot.org/gene3d/3.90.330.10
type: Resource
database: Gene3D
comment: Nitrile hydratase alpha /Thiocyanate hydrolase gamma
signature sequence match: Gene3D 3.90.330.10 match 1

IPR036648
type: Resource
database: InterPro
comment: CN_Hdrase_a/SCN_Hdrase_g_sf

IPR022513
type: Resource
database: InterPro
comment: TOMM_pelo

TIGR03793
type: Resource
database: NCBIfam
comment: leader_NHLP
signature sequence match: NCBIfam TIGR03793 match 1

SSF56209
type: Resource
database: SUPFAM
comment: Nitrile hydratase alpha chain
signature sequence match: SUPFAM SSF56209 match 1

SIP91C0EA046DC28A8E
type: Structured Name
full name: Polytheonamide B

SIP50449BBF388296E7
type: Structured Name
full name: Proteusin

poyA
type: Gene

SIPA81418AFD587FB78
type: Function Annotation
comment: Antimicrobial peptide active against Gram-positive bacteria (MIC=4->125 ug/ml) (PubMed:22983711). May act by forming transmembrane ion channels, since the peptide rapidly depolarizes the bacterial cytoplasmic membrane, simultaneously decreasing the membrane potential and intracellular potassium contents (PubMed:22983711).

SIPC5B60DA08BEB2F93
type: PTM Annotation
comment: Epimerization of most, and perhaps all, L- to D-amino acids is catalyzed by PoyD, when PoyA and PoyD are coexpressed in E.coli.

SIP87FD4491E2276861
type: PTM Annotation
comment: N-methylations are catalyzed by PoyE, when PoyA and PoyE are coexpressed in E.coli.

SIP8B11751368EEE518
type: PTM Annotation
comment: To obtain 2-oxo-5,5-dimethylhexanoate, Thr-97 is firstly dehydrated by PoyF (PubMed:22983711). The second step possibly corresponds to methylation by PoyB/C, and the third step may be a cleavage by PoyH/J (Probable).

SIP56854E68C4365721
type: Annotation
comment: The name 'proteusin' is inspired by Proteus, a Greek shape-shifting sea god.

SIPE7ED0A45C2775042
type: Annotation
comment: Compared to polytheonamide B, polytheonamide A has an additional sulfoxide moiety at Met-141, which arises from spontaneous oxidation during polytheonamide isolation.

20892208467294254tt1
type: Position
type: ExactPosition
position: 1
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

20892208467294254tt96
type: Position
type: ExactPosition
position: 96
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

PRO_0000450587
type: Chain Annotation
comment: Polytheonamide B
mass: 4620
range: 20892208467294254tt97tt145

20892208467294254tt97
type: Position
type: ExactPosition
position: 97
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

20892208467294254tt145
type: Position
type: ExactPosition
position: 145
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

SIP5077ECEB1C6B6E1B
type: Modified Residue Annotation
comment: 2-oxo-5,5-dimethylhexanoate
range: 20892208467294254tt97tt97

SIP0A44D9199156773C
type: Modified Residue Annotation
comment: 3-methylisoleucine
range: 20892208467294254tt99tt99

20892208467294254tt99
type: Position
type: ExactPosition
position: 99
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

SIP451E3E91E288CCBA
type: Modified Residue Annotation
comment: 3-methylvaline
range: 20892208467294254tt101tt101

20892208467294254tt101
type: Position
type: ExactPosition
position: 101
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

SIPD3F0AF7207378C69
type: Modified Residue Annotation
comment: 3-methyl-D-valine
range: 20892208467294254tt102tt102

20892208467294254tt102
type: Position
type: ExactPosition
position: 102
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

SIPF639FC483471CEA9
type: Modified Residue Annotation
comment: 3-methylvaline
range: 20892208467294254tt103tt103

20892208467294254tt103
type: Position
type: ExactPosition
position: 103
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

SIPC1C58A5F7C13AD1D
type: Modified Residue Annotation
comment: D-alanine (Ala)
range: 20892208467294254tt104tt104

20892208467294254tt104
type: Position
type: ExactPosition
position: 104
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

SIP496738436404EEEC
type: Modified Residue Annotation
comment: 3-methylvaline
range: 20892208467294254tt105tt105

20892208467294254tt105
type: Position
type: ExactPosition
position: 105
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

SIP24661210E1C2F690
type: Modified Residue Annotation
comment: 3-methyl-D-valine
range: 20892208467294254tt106tt106

20892208467294254tt106
type: Position
type: ExactPosition
position: 106
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

SIPE43867C0DF912D4C
type: Modified Residue Annotation
comment: 3-methyl-D-valine
range: 20892208467294254tt110tt110

20892208467294254tt110
type: Position
type: ExactPosition
position: 110
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

SIP42CEBFF7537044DA
type: Modified Residue Annotation
comment: N4-methyl-D-asparagine
range: 20892208467294254tt112tt112

20892208467294254tt112
type: Position
type: ExactPosition
position: 112
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

SIP4B014A9D0160E942
type: Modified Residue Annotation
comment: 3-hydroxyvaline (Thr)
range: 20892208467294254tt113tt113

20892208467294254tt113
type: Position
type: ExactPosition
position: 113
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

SIP7FA356F604D40240
type: Modified Residue Annotation
comment: 3-methylvaline
range: 20892208467294254tt117tt117

20892208467294254tt117
type: Position
type: ExactPosition
position: 117
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

SIP641F97B78BB265D1
type: Modified Residue Annotation
comment: N4-methyl-D-asparagine
range: 20892208467294254tt118tt118

20892208467294254tt118
type: Position
type: ExactPosition
position: 118
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

SIP967AE5BD37B1C6DF
type: Modified Residue Annotation
comment: (3S)-3-methylglutamine
range: 20892208467294254tt119tt119

20892208467294254tt119
type: Position
type: ExactPosition
position: 119
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

SIP4B1942D83BEFBA17
type: Modified Residue Annotation
comment: 3-hydroxy-D-valine
range: 20892208467294254tt120tt120

20892208467294254tt120
type: Position
type: ExactPosition
position: 120
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

SIP66E91557493AD028
type: Modified Residue Annotation
comment: N4-methyl-D-asparagine
range: 20892208467294254tt124tt124

20892208467294254tt124
type: Position
type: ExactPosition
position: 124
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

SIP4352D68C47249293
type: Modified Residue Annotation
comment: (3R)-N4-methyl-3-hydroxy-D-asparagine
range: 20892208467294254tt126tt126

20892208467294254tt126
type: Position
type: ExactPosition
position: 126
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

SIP5135A45DC5829E02
type: Modified Residue Annotation
comment: 3-methylvaline
range: 20892208467294254tt127tt127

20892208467294254tt127
type: Position
type: ExactPosition
position: 127
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

SIP7D317315E4784D89
type: Modified Residue Annotation
comment: 3-hydroxy-D-valine
range: 20892208467294254tt128tt128

20892208467294254tt128
type: Position
type: ExactPosition
position: 128
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

SIPE3E6D6C0E089504E
type: Modified Residue Annotation
comment: N4-methyl-D-asparagine
range: 20892208467294254tt130tt130

20892208467294254tt130
type: Position
type: ExactPosition
position: 130
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

SIP396019EED6638AE5
type: Modified Residue Annotation
comment: N4-methyl-D-asparagine
range: 20892208467294254tt132tt132

20892208467294254tt132
type: Position
type: ExactPosition
position: 132
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

SIPA5D14B45260105D6
type: Modified Residue Annotation
comment: (3R)-N4-methyl-3-hydroxy-D-asparagine
range: 20892208467294254tt134tt134

20892208467294254tt134
type: Position
type: ExactPosition
position: 134
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

SIPDCA38475176928AF
type: Modified Residue Annotation
comment: N4-methyl-D-asparagine
range: 20892208467294254tt136tt136

20892208467294254tt136
type: Position
type: ExactPosition
position: 136
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

SIPF0097EBE8BA7421B
type: Modified Residue Annotation
comment: D-serine (Ser)
range: 20892208467294254tt138tt138

20892208467294254tt138
type: Position
type: ExactPosition
position: 138
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

SIP82A891AF685B9B4D
type: Modified Residue Annotation
comment: D-asparagine
range: 20892208467294254tt140tt140

20892208467294254tt140
type: Position
type: ExactPosition
position: 140
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

SIP5FD02CC6B79F245A
type: Modified Residue Annotation
comment: 3,3-dimethylmethionine
range: 20892208467294254tt141tt141

20892208467294254tt141
type: Position
type: ExactPosition
position: 141
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

SIP85270499473C57BE
type: Modified Residue Annotation
comment: D-asparagine
range: 20892208467294254tt142tt142

20892208467294254tt142
type: Position
type: ExactPosition
position: 142
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

SIP1225A1CCF82E8ACB
type: Modified Residue Annotation
comment: D-threonine
range: 20892208467294254tt144tt144

20892208467294254tt144
type: Position
type: ExactPosition
position: 144
reference: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT

MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT
type: Simple Sequence
modified: 2012-11-28
version: 1
precursor: true
mass: 15425

http://purl.uniprot.org/uniprot/J9ZXD8#attribution-5F454683653565DC22F27B8E621915F0
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/22983711

http://purl.uniprot.org/uniprot/J9ZXD8#attribution-8DD7B18F2B0B261097B5F75034B91F5F
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/22983711

http://purl.uniprot.org/uniprot/J9ZXD8#attribution-5A222FA3574CEBD51D02F1D573781D64
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/22983711

http://purl.uniprot.org/uniprot/J9ZXD8#attribution-518EC5AF60B6CE36C6C6F58A0B509E96
manual: true
evidence: ECO_0000312
source: AFS60639.1

O34002
type: Protein
reviewed: true
created: 1999-07-15
modified: 2023-09-13
version: 104
mnemonic: PRPC_ABDS2
old mnemonic: CISY_ABDS2
citation: http://purl.uniprot.org/citations/9310359
citation: http://purl.uniprot.org/citations/9579066
citation: http://purl.uniprot.org/citations/9551556
recommended name: SIP2309EE7D9FD87DF5
alternative name: SIP9CF05426E73D2F72
enzyme: http://purl.uniprot.org/enzyme/2.3.3.5
enzyme: http://purl.uniprot.org/enzyme/2.3.3.16
organism: http://purl.uniprot.org/taxonomy/56673
annotation: SIPAA2B9A91F29D8DB4
annotation: SIPA25AB68882C05C9D
annotation: SIP8936C356DA16594A
annotation: SIP1CE2578F4E1EE832
annotation: SIP05194C6DA195EF9B
annotation: SIP1CCA19C277DB6330
annotation: SIP735AEFD58920A73B
annotation: SIP1CF527DF6C66180F
annotation: SIP7985653862015CC6
annotation: SIP5E03AAA77E804C9F
annotation: SIP645C606671BD7556
annotation: PRO_0000169925
annotation: SIPA8C0180349288367
annotation: SIP63A745EE888AB900
annotation: SIP1DEF9BF145C60582
annotation: SIP85C31DB180AAFFF0
annotation: SIP2ADE224683BA67E6
annotation: SIP7CBE46DE84D74074
annotation: SIP33952D9C8F231AFE
annotation: SIP916A4732BBCD60DB
annotation: SIPC6A14B405F4E94C3
annotation: SIPF9773614DE2D5B62
annotation: SIP695577740F8C107C
annotation: SIP07535160E8E48B54
annotation: SIP32D7F6C1D92C563B
annotation: SIP592AAACE3B76A81B
annotation: SIP0480E53E67880E09
annotation: SIPE60319AD9E1CB172
annotation: SIP3F68C6FEF8A9A01D
annotation: SIP7F0F53C44C1B3FB9
annotation: SIP4B3C8FA4E01254FC
annotation: SIP2CB2E5BAEB25CA46
annotation: SIP3F31D4C6DD9AD135
annotation: SIP33ED81EA85CCF652
annotation: SIPA7C148EF1048B576
annotation: SIP3397A2DF61875D6A
annotation: SIP26E8A6E098F8631F
annotation: SIP3F248A1C6FE21B63
annotation: SIPDCA4F193D82574F4
annotation: SIP00ED6648499CF1E8
annotation: SIPE540B0909469C8E6
annotation: SIP81DA6FAE475F9A0B
annotation: SIPC1C2568B9D38284F
annotation: SIP6FF4DEA933725BFA
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/808
classified with: http://purl.uniprot.org/keywords/816
classified with: GO_0005737
classified with: GO_0050440
classified with: GO_0036440
classified with: GO_0019679
classified with: GO_0006099
sequence: O34002-1

O34002-citation-9310359
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: PROTEIN SEQUENCE OF 2-16
scope: FUNCTION
scope: CATALYTIC ACTIVITY
scope: BIOPHYSICOCHEMICAL PROPERTIES
scope: SUBUNIT

DS2-3R
type: Strain

O34002-citation-9579066
type: Citation Statement
scope: FUNCTION
scope: CATALYTIC ACTIVITY
scope: BIOPHYSICOCHEMICAL PROPERTIES
scope: INDUCTION
scope: SUBSTRATE SPECIFICITY

O34002-citation-9551556
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (2.09 ANGSTROMS) OF 2-379 IN COMPLEX WITH COENZYME A AND SUBSTRATE
scope: ACTIVE SITE
scope: SUBUNIT

1A59
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.09
chain sequence mapping: PDB 1A59 tt2tt379

PDB 1A59 tt2tt379
chain: A=2-379

DB04272
type: Resource
database: DrugBank
comment: Citric acid

DB01992
type: Resource
database: DrugBank
comment: Coenzyme A

http://purl.uniprot.org/brenda/2.3.3.1
type: Resource
database: BRENDA
comment: 15675

cd06111
type: Resource
database: CDD
comment: DsCS_like
signature sequence match: CDD cd06111 match 1

http://purl.uniprot.org/gene3d/1.10.580.10
type: Resource
database: Gene3D
comment: Citrate Synthase, domain 1
signature sequence match: Gene3D 1.10.580.10 match 1

http://purl.uniprot.org/gene3d/1.10.230.10
type: Resource
database: Gene3D
comment: Cytochrome P450-Terp, domain 2
signature sequence match: Gene3D 1.10.230.10 match 1

IPR011278
type: Resource
database: InterPro
comment: 2-MeCitrate/Citrate_synth_II

IPR016142
type: Resource
database: InterPro
comment: Citrate_synth-like_lrg_a-sub

IPR016143
type: Resource
database: InterPro
comment: Citrate_synth-like_sm_a-sub

IPR002020
type: Resource
database: InterPro
comment: Citrate_synthase

IPR019810
type: Resource
database: InterPro
comment: Citrate_synthase_AS

IPR024176
type: Resource
database: InterPro
comment: Citrate_synthase_bac-typ

IPR036969
type: Resource
database: InterPro
comment: Citrate_synthase_sf

TIGR01800
type: Resource
database: NCBIfam
comment: cit_synth_II
signature sequence match: NCBIfam TIGR01800 match 1

PTHR11739
type: Resource
database: PANTHER
comment: CITRATE SYNTHASE
signature sequence match: PANTHER PTHR11739 match 1

PTHR11739:SF4
type: Resource
database: PANTHER
comment: CITRATE SYNTHASE, PEROXISOMAL
signature sequence match: PANTHER PTHR11739:SF4 match 1

PF00285
type: Resource
database: Pfam
comment: Citrate_synt
signature sequence match: Pfam PF00285 match 1

PIRSF001369
type: Resource
database: PIRSF
comment: Citrate_synth
signature sequence match: PIRSF PIRSF001369 match 1

PR00143
type: Resource
database: PRINTS
comment: CITRTSNTHASE

SSF48256
type: Resource
database: SUPFAM
comment: Citrate synthase
signature sequence match: SUPFAM SSF48256 match 1

PS00480
type: Resource
database: PROSITE
comment: CITRATE_SYNTHASE
signature sequence match: PROSITE PS00480 match 1

SIP2309EE7D9FD87DF5
type: Structured Name
full name: 2-methylcitrate synthase
short name: 2-MCS
short name: MCS
ec name: 2.3.3.5

SIP9CF05426E73D2F72
type: Structured Name
full name: Citrate synthase
ec name: 2.3.3.16

gltA
type: Gene
alternative label: cisY

SIPAA2B9A91F29D8DB4
type: Function Annotation
comment: Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield 2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity.

SIP1CE2578F4E1EE832
type: Kinetics Annotation
comment: kcat is 8 sec(-1) for 2-methylcitrate synthase activity with propionyl-CoA as substrate (at pH 8 and 23 degrees Celsius). kcat is 21 sec(-1) for citrate synthase activity with acetyl-CoA as substrate (at pH 8 and 23 degrees Celsius).
measured affinity: 3 uM for oxaloacetate (with propionyl-CoA at pH 8 and 23 degrees Celsius)
measured affinity: 6.9 uM for oxaloacetate (with acetyl-CoA at pH 8 and 23 degrees Celsius)
measured affinity: 7 uM for oxaloacetate (with acetyl-CoA at pH 8 and 23 degrees Celsius)
measured affinity: 16 uM for propionyl-CoA (at pH 8 and 23 degrees Celsius)
measured affinity: 229 uM for acetyl-CoA (at pH 8 and 23 degrees Celsius)
measured affinity: 230 uM for acetyl-CoA (at pH 8 and 23 degrees Celsius)
measured activity: 12 umol/min/mg enzyme with propionyl-CoA as substrate (at pH 8 and 23 degrees Celsius)
measured activity: 30 umol/min/mg enzyme with acetyl-CoA as substrate (at pH 8 and 23 degrees Celsius)

SIP05194C6DA195EF9B
type: Temperature Dependence Annotation
comment: Optimum temperature is 31 degrees Celsius. Cold-active. Is rapidly inactivated at 45 degrees Celsius, and shows significant activity at 10 degrees Celsius and below.

SIP1CF527DF6C66180F
type: Subunit Annotation
comment: Homodimer.

SIP7985653862015CC6
type: Induction Annotation
comment: By growth on propionate, but not acetate or glucose.

SIP5E03AAA77E804C9F
type: Similarity Annotation
comment: Belongs to the citrate synthase family.

SIP645C606671BD7556
type: Initiator Methionine Annotation
comment: Removed
range: 22292822399922734tt1tt1

22292822399922734tt1
type: Position
type: ExactPosition
position: 1
reference: O34002-1

PRO_0000169925
type: Chain Annotation
comment: 2-methylcitrate synthase
mass: 41701
range: 22292822399922734tt2tt379

22292822399922734tt2
type: Position
type: ExactPosition
position: 2
reference: O34002-1

22292822399922734tt379
type: Position
type: ExactPosition
position: 379
reference: O34002-1

22292822399922734tt222
type: Position
type: ExactPosition
position: 222
reference: O34002-1

22292822399922734tt270
type: Position
type: ExactPosition
position: 270
reference: O34002-1

22292822399922734tt321
type: Position
type: ExactPosition
position: 321
reference: O34002-1

22292822399922734tt187
type: Position
type: ExactPosition
position: 187
reference: O34002-1

22292822399922734tt264
type: Position
type: ExactPosition
position: 264
reference: O34002-1

22292822399922734tt268
type: Position
type: ExactPosition
position: 268
reference: O34002-1

22292822399922734tt279
type: Position
type: ExactPosition
position: 279
reference: O34002-1

22292822399922734tt346
type: Position
type: ExactPosition
position: 346
reference: O34002-1

22292822399922734tt365
type: Position
type: ExactPosition
position: 365
reference: O34002-1

22292822399922734tt8
type: Position
type: ExactPosition
position: 8
reference: O34002-1

22292822399922734tt10
type: Position
type: ExactPosition
position: 10
reference: O34002-1

22292822399922734tt19
type: Position
type: ExactPosition
position: 19
reference: O34002-1

22292822399922734tt24
type: Position
type: ExactPosition
position: 24
reference: O34002-1

22292822399922734tt25
type: Position
type: ExactPosition
position: 25
reference: O34002-1

22292822399922734tt28
type: Position
type: ExactPosition
position: 28
reference: O34002-1

22292822399922734tt29
type: Position
type: ExactPosition
position: 29
reference: O34002-1

22292822399922734tt32
type: Position
type: ExactPosition
position: 32
reference: O34002-1

22292822399922734tt37
type: Position
type: ExactPosition
position: 37
reference: O34002-1

22292822399922734tt43
type: Position
type: ExactPosition
position: 43
reference: O34002-1

22292822399922734tt46
type: Position
type: ExactPosition
position: 46
reference: O34002-1

22292822399922734tt55
type: Position
type: ExactPosition
position: 55
reference: O34002-1

22292822399922734tt61
type: Position
type: ExactPosition
position: 61
reference: O34002-1

22292822399922734tt72
type: Position
type: ExactPosition
position: 72
reference: O34002-1

22292822399922734tt79
type: Position
type: ExactPosition
position: 79
reference: O34002-1

22292822399922734tt85
type: Position
type: ExactPosition
position: 85
reference: O34002-1

22292822399922734tt94
type: Position
type: ExactPosition
position: 94
reference: O34002-1

22292822399922734tt107
type: Position
type: ExactPosition
position: 107
reference: O34002-1

22292822399922734tt110
type: Position
type: ExactPosition
position: 110
reference: O34002-1

22292822399922734tt113
type: Position
type: ExactPosition
position: 113
reference: O34002-1

22292822399922734tt117
type: Position
type: ExactPosition
position: 117
reference: O34002-1

22292822399922734tt142
type: Position
type: ExactPosition
position: 142
reference: O34002-1

22292822399922734tt156
type: Position
type: ExactPosition
position: 156
reference: O34002-1

22292822399922734tt165
type: Position
type: ExactPosition
position: 165
reference: O34002-1

22292822399922734tt171
type: Position
type: ExactPosition
position: 171
reference: O34002-1

22292822399922734tt184
type: Position
type: ExactPosition
position: 184
reference: O34002-1

22292822399922734tt191
type: Position
type: ExactPosition
position: 191
reference: O34002-1

22292822399922734tt200
type: Position
type: ExactPosition
position: 200
reference: O34002-1

22292822399922734tt201
type: Position
type: ExactPosition
position: 201
reference: O34002-1

22292822399922734tt203
type: Position
type: ExactPosition
position: 203
reference: O34002-1

22292822399922734tt206
type: Position
type: ExactPosition
position: 206
reference: O34002-1

22292822399922734tt218
type: Position
type: ExactPosition
position: 218
reference: O34002-1

22292822399922734tt220
type: Position
type: ExactPosition
position: 220
reference: O34002-1

22292822399922734tt224
type: Position
type: ExactPosition
position: 224
reference: O34002-1

22292822399922734tt225
type: Position
type: ExactPosition
position: 225
reference: O34002-1

22292822399922734tt235
type: Position
type: ExactPosition
position: 235
reference: O34002-1

22292822399922734tt244
type: Position
type: ExactPosition
position: 244
reference: O34002-1

22292822399922734tt260
type: Position
type: ExactPosition
position: 260
reference: O34002-1

22292822399922734tt280
type: Position
type: ExactPosition
position: 280
reference: O34002-1

22292822399922734tt293
type: Position
type: ExactPosition
position: 293
reference: O34002-1

22292822399922734tt298
type: Position
type: ExactPosition
position: 298
reference: O34002-1

22292822399922734tt314
type: Position
type: ExactPosition
position: 314
reference: O34002-1

22292822399922734tt330
type: Position
type: ExactPosition
position: 330
reference: O34002-1

22292822399922734tt335
type: Position
type: ExactPosition
position: 335
reference: O34002-1

22292822399922734tt337
type: Position
type: ExactPosition
position: 337
reference: O34002-1

22292822399922734tt338
type: Position
type: ExactPosition
position: 338
reference: O34002-1

22292822399922734tt359
type: Position
type: ExactPosition
position: 359
reference: O34002-1

substrate

O34002-1
type: Simple Sequence
modified: 1998-01-01
version: 1
mass: 41832
value: MTEPTIHKGLAGVTADVTAISKVNSDTNSLLYRGYPVQELAAKCSFEQVAYLLWNSELPNDSELKAFVNFERSHRKLDENVKGAIDLLSTACHPMDVARTAVSVLGANHARAQDSSPEANLEKAMSLLATFPSVVAYDQRRRRGEELIEPREDLDYSANFLWMTFGEEAAPEVVEAFNVSMILYAEHSFNASTFTARVITSTLADLHSAVTGAIGALKGPLHGGANEAVMHTFEEIGIRKDESLDEAATRSKAWMVDALAQKKKVMGFGHRVYKNGDSRVPTMKSALDAMIKHYDRPEMLGLYNGLEAAMEEAKQIKPNLDYPAGPTYNLMGFDTEMFTPLFIAARITGWTAHIMEQVADNALIRPLSEYNGPEQRQVP

http://purl.uniprot.org/uniprot/O34002#attribution-19E4B755F3B15D3344A6731EE539F951
creator: UniProtKB
manual: true
evidence: ECO_0000314
source: http://purl.uniprot.org/citations/9579066

http://purl.uniprot.org/uniprot/O34002#attribution-201664EFF50A29AC73A8C9B5FA141818
creator: UniProtKB
manual: true
evidence: ECO_0000314
source: http://purl.uniprot.org/citations/9310359

http://purl.uniprot.org/uniprot/O34002#attribution-E4C75DCD74DD3B6E66D3223F80167B4E
manual: true
evidence: ECO_0000250
source: I6Y9Q3

http://purl.uniprot.org/uniprot/O34002#attribution-D052F1CBC8160FE5C25934997905577F
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/9310359

http://purl.uniprot.org/uniprot/O34002#attribution-C7ABC6E26A264F8FEE71D927C736465D
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/9551556

http://purl.uniprot.org/uniprot/O34002#attribution-6572902B07FBBF8AE8C5E41B753DBC0F
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/9579066

http://purl.uniprot.org/uniprot/O34002#attribution-134232C9B98E354CD607132C83679EB3
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/9310359

http://purl.uniprot.org/uniprot/O34002#attribution-A9376E63353229414D547E709F8B8451
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/9579066

http://purl.uniprot.org/uniprot/O34002#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

http://purl.uniprot.org/uniprot/O34002#attribution-77BC440BC471CCFBD18BBBF9229ADB81
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/9579066

P07472
type: Protein
reviewed: true
created: 1988-04-01
modified: 2023-09-13
version: 101
mnemonic: RL7_HALEU
old mnemonic: RLA_HALEU
citation: http://purl.uniprot.org/citations/3756001
citation: http://purl.uniprot.org/citations/454666
recommended name: SIP90B44CD0F427EC8A
alternative name: SIP2BAC4DBDA7F1FC6F
alternative name: SIPC63989D0993B1C53
organism: http://purl.uniprot.org/taxonomy/27
annotation: SIPF31FF7B1C8418EFF
annotation: SIP29891340260F5857
annotation: SIP81000078B134853B
annotation: SIPA834E61789DA0C5A
annotation: SIP1F07DC1BBD60850F
annotation: PRO_0000157534
annotation: SIPB51C1FFF0BE5C0D5
annotation: SIPFCAFCED6477E15B6
annotation: SIP552F17C97719A1F6
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/488
classified with: http://purl.uniprot.org/keywords/689
classified with: GO_1990904
classified with: GO_0005840
classified with: GO_0003735
classified with: GO_0006412
sequence: MALTQEDIINAVAEMSVMEVAELVSAMEEKFGVSAAAAVVAGPGGGEAEEAEEQTEFDLVLTSAGEKKVNVIKVVREITGLGLKEAKAAVDGAPATLKEGMSKEDGDEAKTKLEEAGASVELK

P07472-citation-3756001
type: Citation Statement
scope: PROTEIN SEQUENCE OF 2-123

P07472-citation-454666
type: Citation Statement
scope: PROTEIN SEQUENCE OF 2-39
scope: METHYLATION AT LYS-84

cd00387
type: Resource
database: CDD
comment: Ribosomal_L7_L12
signature sequence match: CDD cd00387 match 1

http://purl.uniprot.org/gene3d/1.20.5.710
type: Resource
database: Gene3D
comment: Single helix bin
signature sequence match: Gene3D 1.20.5.710 match 1

MF_00368
type: Resource
database: HAMAP
comment: Ribosomal_L7_L12
signature sequence match: HAMAP MF 00368 match 1

IPR000206
type: Resource
database: InterPro
comment: Ribosomal_L7/12

IPR014719
type: Resource
database: InterPro
comment: Ribosomal_L7/12_C/ClpS-like

IPR013823
type: Resource
database: InterPro
comment: Ribosomal_L7/L12_C

IPR008932
type: Resource
database: InterPro
comment: Ribosomal_L7/L12_oligo

IPR036235
type: Resource
database: InterPro
comment: Ribosomal_L7/L12_oligo_N_sf

TIGR00855
type: Resource
database: NCBIfam
comment: L12
signature sequence match: NCBIfam TIGR00855 match 1

PTHR45987
type: Resource
database: PANTHER
comment: 39S RIBOSOMAL PROTEIN L12
signature sequence match: PANTHER PTHR45987 match 1

PTHR45987:SF4
type: Resource
database: PANTHER
comment: 39S RIBOSOMAL PROTEIN L12, MITOCHONDRIAL
signature sequence match: PANTHER PTHR45987:SF4 match 1

PF00542
type: Resource
database: Pfam
comment: Ribosomal_L12
signature sequence match: Pfam PF00542 match 1

PF16320
type: Resource
database: Pfam
comment: Ribosomal_L12_N
signature sequence match: Pfam PF16320 match 1

SSF54736
type: Resource
database: SUPFAM
comment: ClpS-like
signature sequence match: SUPFAM SSF54736 match 1

SSF48300
type: Resource
database: SUPFAM
comment: Ribosomal protein L7/12, oligomerisation (N-terminal) domain
signature sequence match: SUPFAM SSF48300 match 1

SIP90B44CD0F427EC8A
type: Structured Name
full name: Large ribosomal subunit protein bL12

SIP2BAC4DBDA7F1FC6F
type: Structured Name
full name: 50S ribosomal protein L7/L12

SIPC63989D0993B1C53
type: Structured Name
full name: Ribosomal protein 'A'

rplL
type: Gene

SIPF31FF7B1C8418EFF
type: Function Annotation
comment: Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation.

SIP29891340260F5857
type: Function Annotation
comment: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.

SIP81000078B134853B
type: Subunit Annotation
comment: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

SIPA834E61789DA0C5A
type: Similarity Annotation
comment: Belongs to the bacterial ribosomal protein bL12 family.

SIP1F07DC1BBD60850F
type: Initiator Methionine Annotation
comment: Removed
range: 22571011794219566tt1tt1

22571011794219566tt1
type: Position
type: ExactPosition
position: 1
reference: MALTQEDIINAVAEMSVMEVAELVSAMEEKFGVSAAAAVVAGPGGGEAEEAEEQTEFDLVLTSAGEKKVNVIKVVREITGLGLKEAKAAVDGAPATLKEGMSKEDGDEAKTKLEEAGASVELK

PRO_0000157534
type: Chain Annotation
comment: Large ribosomal subunit protein bL12
mass: 12534
range: 22571011794219566tt2tt123

22571011794219566tt2
type: Position
type: ExactPosition
position: 2
reference: MALTQEDIINAVAEMSVMEVAELVSAMEEKFGVSAAAAVVAGPGGGEAEEAEEQTEFDLVLTSAGEKKVNVIKVVREITGLGLKEAKAAVDGAPATLKEGMSKEDGDEAKTKLEEAGASVELK

22571011794219566tt123
type: Position
type: ExactPosition
position: 123
reference: MALTQEDIINAVAEMSVMEVAELVSAMEEKFGVSAAAAVVAGPGGGEAEEAEEQTEFDLVLTSAGEKKVNVIKVVREITGLGLKEAKAAVDGAPATLKEGMSKEDGDEAKTKLEEAGASVELK

SIPB51C1FFF0BE5C0D5
type: Region Annotation
comment: Disordered
range: 22571011794219566tt94tt123

22571011794219566tt94
type: Position
type: ExactPosition
position: 94
reference: MALTQEDIINAVAEMSVMEVAELVSAMEEKFGVSAAAAVVAGPGGGEAEEAEEQTEFDLVLTSAGEKKVNVIKVVREITGLGLKEAKAAVDGAPATLKEGMSKEDGDEAKTKLEEAGASVELK

SIPFCAFCED6477E15B6
type: Compositional Bias Annotation
comment: Basic and acidic residues
range: 22571011794219566tt98tt123

22571011794219566tt98
type: Position
type: ExactPosition
position: 98
reference: MALTQEDIINAVAEMSVMEVAELVSAMEEKFGVSAAAAVVAGPGGGEAEEAEEQTEFDLVLTSAGEKKVNVIKVVREITGLGLKEAKAAVDGAPATLKEGMSKEDGDEAKTKLEEAGASVELK

SIP552F17C97719A1F6
type: Modified Residue Annotation
comment: N6-methyllysine
range: 22571011794219566tt84tt84

22571011794219566tt84
type: Position
type: ExactPosition
position: 84
reference: MALTQEDIINAVAEMSVMEVAELVSAMEEKFGVSAAAAVVAGPGGGEAEEAEEQTEFDLVLTSAGEKKVNVIKVVREITGLGLKEAKAAVDGAPATLKEGMSKEDGDEAKTKLEEAGASVELK

MALTQEDIINAVAEMSVMEVAELVSAMEEKFGVSAAAAVVAGPGGGEAEEAEEQTEFDLVLTSAGEKKVNVIKVVREITGLGLKEAKAAVDGAPATLKEGMSKEDGDEAKTKLEEAGASVELK
type: Simple Sequence
modified: 2007-01-23
version: 2
mass: 12665

http://purl.uniprot.org/uniprot/P07472#attribution-11708D8908E6D7A55FA3E57E4633D9D1
manual: true
evidence: ECO_0000255
source: MF_00368

http://purl.uniprot.org/uniprot/P07472#attribution-5CBA56B1CFD78C26365E11B17D90BBBA
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/3756001

http://purl.uniprot.org/uniprot/P07472#attribution-0A6C0B245025D22FC5ECC2373A14E508
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/454666

http://purl.uniprot.org/uniprot/P07472#attribution-8E46A4482B9627E70753146E6F0A49F8
manual: true
evidence: ECO_0000305

Q54506
type: Protein
reviewed: true
created: 2000-05-30
modified: 2023-09-13
version: 103
mnemonic: SAT_RIFPS
citation: http://purl.uniprot.org/citations/8206850
recommended name: SIP8D282937AC1956F8
alternative name: SIP765D0E7B9AC66D95
alternative name: SIP73256915A3BE5AFD
enzyme: http://purl.uniprot.org/enzyme/2.7.7.4
organism: http://purl.uniprot.org/taxonomy/35843
annotation: SIP8ED48FDD667A6473
annotation: SIP0C3537AED48C38C7
annotation: SIPC6CD06A91B3386EB
annotation: PRO_0000105941
annotation: SIPD7413A8364533F1B
annotation: SIPBD22B966096F4816
annotation: SIPF692BEA4193E77D0
annotation: SIPE878D655181B918B
annotation: SIP9BC4AB723A0E2E5E
annotation: SIPEF858A1BAB5FF4E8
annotation: SIP6E36A793C1E41839
annotation: SIP4D3EB4735B9A17F0
annotation: SIPF450DCDEF00D98E2
annotation: SIP32515FD632710093
annotation: SIP30175ECDAD1BB8F0
annotation: SIP3FAC44F788F1A3C1
annotation: SIP4D4732B4100A5D08
annotation: SIP6BABB3D2E0399C04
annotation: SIP9927661958866591
annotation: SIPE6CF5635E5627F83
annotation: SIPB112AE9171671892
annotation: SIP8A0CCEB296C38EFB
annotation: SIP85CEF23A840A90C3
annotation: SIP2E8679BB6AF08CF6
annotation: SIPB44D8E801D69370E
annotation: SIPF807DA251455C439
annotation: SIPB03BB1AC1ED002B7
annotation: SIP82E521D52BD3E78F
annotation: SIP6AF6D7F545569818
annotation: SIPF162E4E22B6C01AC
annotation: SIPDB9A2EE63030838F
annotation: SIP93E7DDEF0F1508A9
annotation: SIPFEDD216EA91976AC
annotation: SIP7264E7142F6C3F86
annotation: SIPF903696B2EEF897A
annotation: SIP2A7C9D7CD2F48B2D
annotation: SIPB717D35A392F9ACC
annotation: SIP557F3849949EDC76
annotation: SIPCA225FD47EF25073
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/548
classified with: GO_0005524
classified with: GO_0004781
classified with: GO_0070814
classified with: GO_0000103
sequence: Q54506-1

Q54506-citation-8206850
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

1JHD
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 1.70
chain sequence mapping: PDB 1JHD tt1tt386

PDB 1JHD tt1tt386
chain: A=1-386

http://purl.uniprot.org/gene3d/3.40.50.620
type: Resource
database: Gene3D
comment: HUPs
signature sequence match: Gene3D 3.40.50.620 match 1

http://purl.uniprot.org/gene3d/3.10.400.10
type: Resource
database: Gene3D
comment: Sulfate adenylyltransferase
signature sequence match: Gene3D 3.10.400.10 match 1

MF_00066
type: Resource
database: HAMAP
comment: Sulf_adenylyltr
signature sequence match: HAMAP MF 00066 match 1

IPR025980
type: Resource
database: InterPro
comment: ATP-Sase_PUA-like_dom

IPR015947
type: Resource
database: InterPro
comment: PUA-like_sf

IPR014729
type: Resource
database: InterPro
comment: Rossmann-like_a/b/a_fold

IPR020792
type: Resource
database: InterPro
comment: SO4_adenylyltransferase_pro

IPR024951
type: Resource
database: InterPro
comment: Sulfurylase_cat_dom

IPR002650
type: Resource
database: InterPro
comment: Sulphate_adenylyltransferase

TIGR00339
type: Resource
database: NCBIfam
comment: sopT
signature sequence match: NCBIfam TIGR00339 match 1

PTHR43509
type: Resource
database: PANTHER
comment: PTHR43509
signature sequence match: PANTHER PTHR43509 match 1

PTHR43509:SF1
type: Resource
database: PANTHER
comment: SULFATE ADENYLYLTRANSFERASE-RELATED
signature sequence match: PANTHER PTHR43509:SF1 match 1

PF01747
type: Resource
database: Pfam
comment: ATP-sulfurylase
signature sequence match: Pfam PF01747 match 1

PF14306
type: Resource
database: Pfam
comment: PUA_2
signature sequence match: Pfam PF14306 match 1

SSF52374
type: Resource
database: SUPFAM
comment: Nucleotidylyl transferase
signature sequence match: SUPFAM SSF52374 match 1

SSF88697
type: Resource
database: SUPFAM
comment: PUA domain-like
signature sequence match: SUPFAM SSF88697 match 1

SIP8D282937AC1956F8
type: Structured Name
full name: Sulfate adenylyltransferase
ec name: 2.7.7.4

SIP765D0E7B9AC66D95
type: Structured Name
full name: ATP-sulfurylase

SIP73256915A3BE5AFD
type: Structured Name
full name: Sulfate adenylate transferase
short name: SAT

sat
type: Gene
alternative label: sopT

SIPC6CD06A91B3386EB
type: Similarity Annotation
comment: Belongs to the sulfate adenylyltransferase family.

PRO_0000105941
type: Chain Annotation
comment: Sulfate adenylyltransferase
mass: 48229
range: 22857971460486702tt1tt437

22857971460486702tt1
type: Position
type: ExactPosition
position: 1
reference: Q54506-1

22857971460486702tt437
type: Position
type: ExactPosition
position: 437
reference: Q54506-1

SIPD7413A8364533F1B
type: Region Annotation
comment: Disordered
range: 22857971460486702tt303tt322

22857971460486702tt303
type: Position
type: ExactPosition
position: 303
reference: Q54506-1

22857971460486702tt322
type: Position
type: ExactPosition
position: 322
reference: Q54506-1

SIPBD22B966096F4816
type: Compositional Bias Annotation
comment: Polar residues
range: 22857971460486702tt303tt321

22857971460486702tt321
type: Position
type: ExactPosition
position: 321
reference: Q54506-1

22857971460486702tt7
type: Position
type: ExactPosition
position: 7
reference: Q54506-1

22857971460486702tt9
type: Position
type: ExactPosition
position: 9
reference: Q54506-1

22857971460486702tt18
type: Position
type: ExactPosition
position: 18
reference: Q54506-1

22857971460486702tt28
type: Position
type: ExactPosition
position: 28
reference: Q54506-1

22857971460486702tt33
type: Position
type: ExactPosition
position: 33
reference: Q54506-1

22857971460486702tt35
type: Position
type: ExactPosition
position: 35
reference: Q54506-1

22857971460486702tt38
type: Position
type: ExactPosition
position: 38
reference: Q54506-1

22857971460486702tt48
type: Position
type: ExactPosition
position: 48
reference: Q54506-1

22857971460486702tt49
type: Position
type: ExactPosition
position: 49
reference: Q54506-1

22857971460486702tt54
type: Position
type: ExactPosition
position: 54
reference: Q54506-1

22857971460486702tt60
type: Position
type: ExactPosition
position: 60
reference: Q54506-1

22857971460486702tt69
type: Position
type: ExactPosition
position: 69
reference: Q54506-1

22857971460486702tt84
type: Position
type: ExactPosition
position: 84
reference: Q54506-1

22857971460486702tt86
type: Position
type: ExactPosition
position: 86
reference: Q54506-1

22857971460486702tt89
type: Position
type: ExactPosition
position: 89
reference: Q54506-1

22857971460486702tt93
type: Position
type: ExactPosition
position: 93
reference: Q54506-1

22857971460486702tt95
type: Position
type: ExactPosition
position: 95
reference: Q54506-1

22857971460486702tt100
type: Position
type: ExactPosition
position: 100
reference: Q54506-1

22857971460486702tt109
type: Position
type: ExactPosition
position: 109
reference: Q54506-1

22857971460486702tt114
type: Position
type: ExactPosition
position: 114
reference: Q54506-1

22857971460486702tt117
type: Position
type: ExactPosition
position: 117
reference: Q54506-1

22857971460486702tt120
type: Position
type: ExactPosition
position: 120
reference: Q54506-1

22857971460486702tt123
type: Position
type: ExactPosition
position: 123
reference: Q54506-1

22857971460486702tt134
type: Position
type: ExactPosition
position: 134
reference: Q54506-1

22857971460486702tt142
type: Position
type: ExactPosition
position: 142
reference: Q54506-1

22857971460486702tt147
type: Position
type: ExactPosition
position: 147
reference: Q54506-1

22857971460486702tt152
type: Position
type: ExactPosition
position: 152
reference: Q54506-1

22857971460486702tt161
type: Position
type: ExactPosition
position: 161
reference: Q54506-1

22857971460486702tt165
type: Position
type: ExactPosition
position: 165
reference: Q54506-1

22857971460486702tt170
type: Position
type: ExactPosition
position: 170
reference: Q54506-1

22857971460486702tt172
type: Position
type: ExactPosition
position: 172
reference: Q54506-1

22857971460486702tt174
type: Position
type: ExactPosition
position: 174
reference: Q54506-1

22857971460486702tt178
type: Position
type: ExactPosition
position: 178
reference: Q54506-1

22857971460486702tt188
type: Position
type: ExactPosition
position: 188
reference: Q54506-1

22857971460486702tt191
type: Position
type: ExactPosition
position: 191
reference: Q54506-1

22857971460486702tt200
type: Position
type: ExactPosition
position: 200
reference: Q54506-1

22857971460486702tt204
type: Position
type: ExactPosition
position: 204
reference: Q54506-1

22857971460486702tt217
type: Position
type: ExactPosition
position: 217
reference: Q54506-1

22857971460486702tt220
type: Position
type: ExactPosition
position: 220
reference: Q54506-1

22857971460486702tt228
type: Position
type: ExactPosition
position: 228
reference: Q54506-1

22857971460486702tt238
type: Position
type: ExactPosition
position: 238
reference: Q54506-1

22857971460486702tt252
type: Position
type: ExactPosition
position: 252
reference: Q54506-1

22857971460486702tt258
type: Position
type: ExactPosition
position: 258
reference: Q54506-1

22857971460486702tt264
type: Position
type: ExactPosition
position: 264
reference: Q54506-1

22857971460486702tt272
type: Position
type: ExactPosition
position: 272
reference: Q54506-1

22857971460486702tt284
type: Position
type: ExactPosition
position: 284
reference: Q54506-1

22857971460486702tt288
type: Position
type: ExactPosition
position: 288
reference: Q54506-1

22857971460486702tt292
type: Position
type: ExactPosition
position: 292
reference: Q54506-1

22857971460486702tt294
type: Position
type: ExactPosition
position: 294
reference: Q54506-1

22857971460486702tt299
type: Position
type: ExactPosition
position: 299
reference: Q54506-1

22857971460486702tt300
type: Position
type: ExactPosition
position: 300
reference: Q54506-1

22857971460486702tt307
type: Position
type: ExactPosition
position: 307
reference: Q54506-1

22857971460486702tt325
type: Position
type: ExactPosition
position: 325
reference: Q54506-1

22857971460486702tt326
type: Position
type: ExactPosition
position: 326
reference: Q54506-1

22857971460486702tt329
type: Position
type: ExactPosition
position: 329
reference: Q54506-1

22857971460486702tt330
type: Position
type: ExactPosition
position: 330
reference: Q54506-1

22857971460486702tt333
type: Position
type: ExactPosition
position: 333
reference: Q54506-1

22857971460486702tt356
type: Position
type: ExactPosition
position: 356
reference: Q54506-1

22857971460486702tt359
type: Position
type: ExactPosition
position: 359
reference: Q54506-1

22857971460486702tt362
type: Position
type: ExactPosition
position: 362
reference: Q54506-1

22857971460486702tt366
type: Position
type: ExactPosition
position: 366
reference: Q54506-1

22857971460486702tt373
type: Position
type: ExactPosition
position: 373
reference: Q54506-1

22857971460486702tt375
type: Position
type: ExactPosition
position: 375
reference: Q54506-1

22857971460486702tt378
type: Position
type: ExactPosition
position: 378
reference: Q54506-1

22857971460486702tt386
type: Position
type: ExactPosition
position: 386
reference: Q54506-1

Q54506-1
type: Simple Sequence
modified: 1996-11-01
version: 1
mass: 48229
value: MIKPVGSDELKPLFVYDPEEHHKLSHEAESLPSVVISSQGPRVSSMMGAGYFSPAGFMNVADAMGAAEKMTLSDGSSSCSVLCLLENTDAIGDAKRIALRDPNVEGNPVLAVMDIEAIEEVSDEQMAVMTDKVYRTTDMDHIGVKTFNSQGRVAVSGPIQVLNFSYFQADFPDTFRTAVEIRNEIKEHGWSKVVAFQTRNPMHRAHEELCRMPMESLDADGVVVHMLLGKLKKGDIPAPVRDAAIRTMAEVYFPPNTVMVTGYGFDMLYAGPREAVLHAYFRQNMGATHFIIGREPPAWVTTTVPSTPRPSSMTKCQRAPWRSRSSCRPHGLLQEAEQDCDDARRAGSHQGRLRTALRHQGREMLGQGIAPPPEFSRPEVAKILMDLLPVHQQLILIWFSGKTRPGVGRWRVFLCAAGALWPEAVAVANMEKRSSTG

http://purl.uniprot.org/uniprot/Q54506#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305