E2RU97
type: Protein
reviewed: true
created: 2022-08-03
modified: 2023-05-03
version: 62
mnemonic: 1433_GIAIC
citation: http://purl.uniprot.org/citations/16368691
citation: http://purl.uniprot.org/citations/17901334
citation: http://purl.uniprot.org/citations/24658679
citation: http://purl.uniprot.org/citations/21135098
citation: http://purl.uniprot.org/citations/19733174
citation: http://purl.uniprot.org/citations/19861170
citation: http://purl.uniprot.org/citations/23058231
citation: http://purl.uniprot.org/citations/22452640
citation: http://purl.uniprot.org/citations/24147113
citation: http://purl.uniprot.org/citations/24728194
citation: http://purl.uniprot.org/citations/28932813
citation: http://purl.uniprot.org/citations/26551337
recommended name: SIPB80C1032135BFDE2
alternative name: SIPE61005D5558A6D92
alternative name: SIP44606DD3F01BDF3C
organism: http://purl.uniprot.org/taxonomy/184922
annotation: SIP01AEB8314B46F75F
annotation: SIPC51AF7614BAF32D6
annotation: SIP1795377CB3A9E2B0
annotation: SIPAD114ED96AC918E6
annotation: SIPB8087EF954557293
annotation: SIP9CA7B40B1C42F35E
annotation: SIP374A2556F0F88ACB
annotation: SIPF0534E27DB61299D
annotation: SIP69C2CBDFC94F20CC
annotation: SIPD7404D3B5B32D1C4
annotation: SIP137C9840A972FD41
annotation: PRO_0000455962
annotation: SIPE365C39B67BF4EA8
annotation: SIP7DB7472E6B4AF8D2
annotation: SIPD2E8563C1B0190E7
annotation: SIP12AFA62A13FBCB24
annotation: SIP32AE70EF65031D69
annotation: SIP537C0059F45983A6
annotation: SIP8AC0E453482B3106
annotation: SIPC7A5440C6224020F
annotation: SIP83250CE8B8461DFA
annotation: SIPEF27A8C979AD41E4
annotation: SIPA8411A617A8B39F4
annotation: SIPDF3F64519C0941BE
annotation: SIP85DA11298C8E515C
annotation: SIP7CCA523F2C98B21B
annotation: SIP78C1FF90A603B893
annotation: SIPB2827E98EFB86C6F
annotation: SIP776BE94C7EA77319
annotation: SIP4FA8C88D9F9A66D8
annotation: SIP9E994F5A28738E52
annotation: SIPC7A9BE82EA55B227
annotation: SIP7D2FEB298A3B601C
annotation: SIP0E1A45493FA3AA25
annotation: SIPF2AFAC0787CDB8A1
annotation: SIPCCF8C5A2A3FA2172
annotation: SIP47F858F59A27694E
annotation: SIP90CBAB4BBC40804A
annotation: SIPF2382EE9C228673A
annotation: SIP5E459600B949D833
annotation: SIP455CE8A2E6401B0D
annotation: SIP2E966E85170269F1
annotation: SIPF958431D420013C8
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/175
classified with: http://purl.uniprot.org/keywords/206
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/256
classified with: http://purl.uniprot.org/keywords/282
classified with: http://purl.uniprot.org/keywords/1017
classified with: http://purl.uniprot.org/keywords/539
classified with: http://purl.uniprot.org/keywords/597
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0005930
classified with: GO_0005737
classified with: GO_0005856
classified with: GO_0005783

E2RU97-citation-16368691
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: PROTEIN SEQUENCE OF 202-219
scope: FUNCTION
scope: SUBUNIT
scope: SUBCELLULAR LOCATION
scope: DEVELOPMENTAL STAGE
scope: INDUCTION
scope: PTM
scope: PHOSPHORYLATION AT THR-214
scope: POLYGLYCYLATION
scope: MUTAGENESIS OF LYS-53 AND THR-214

ATCC 50803 / WB clone C6
type: Strain

E2RU97-citation-17901334
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

E2RU97-citation-24658679
type: Citation Statement
scope: PROTEIN SEQUENCE OF 202-219
scope: X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) OF THE UNPHOSPHORYLATED UNPOLYGLYCYLATED FORM
scope: SUBUNIT
scope: DEVELOPMENTAL STAGE
scope: PTM
scope: IDENTIFICATION BY MASS SPECTROMETRY
scope: PHOSPHORYLATION AT THR-214
scope: POLYGLYCYLATION
scope: MUTAGENESIS OF ARG-200; THR-208; THR-214; GLU-247 AND LYS-248
scope: CIRCULAR DICHROISM ANALYSIS

E2RU97-citation-21135098
type: Citation Statement
scope: PROTEIN SEQUENCE OF 230-248
scope: SUBCELLULAR LOCATION
scope: DEVELOPMENTAL STAGE
scope: PTM
scope: POLYGLYCYLATION
scope: IDENTIFICATION BY MASS SPECTROMETRY

E2RU97-citation-19733174
type: Citation Statement
scope: FUNCTION
scope: SUBCELLULAR LOCATION
scope: DEVELOPMENTAL STAGE
scope: PTM
scope: PHOSPHORYLATION AT THR-214
scope: GLYCYLATION AT GLU-246
scope: MUTAGENESIS OF LYS-53; VAL-183; THR-214; GLU-246 AND GLU-247

E2RU97-citation-19861170
type: Citation Statement
scope: SUBCELLULAR LOCATION
scope: DEVELOPMENTAL STAGE
scope: PHOSPHORYLATION
scope: IDENTIFICATION BY MASS SPECTROMETRY

E2RU97-citation-23058231
type: Citation Statement
scope: DEVELOPMENTAL STAGE

E2RU97-citation-22452640
type: Citation Statement
scope: SUBUNIT
scope: INTERACTION WITH GL50803_112076; GL50803_94117; GL50803_11043; GL50803_17143; GL50803_13608; GL50803_22165; GL50803_34684 AND GL50803_17472
scope: SUBCELLULAR LOCATION
scope: DEVELOPMENTAL STAGE

E2RU97-citation-24147113
type: Citation Statement
scope: SUBCELLULAR LOCATION
scope: DEVELOPMENTAL STAGE
scope: PHOSPHORYLATION AT THR-214
scope: POLYGLYCYLATION

E2RU97-citation-24728194
type: Citation Statement
scope: INTERACTION WITH ACTIN
scope: SUBCELLULAR LOCATION
scope: DEVELOPMENTAL STAGE
scope: IDENTIFICATION BY MASS SPECTROMETRY

E2RU97-citation-28932813
type: Citation Statement
scope: FUNCTION
scope: SUBUNIT
scope: INTERACTION WITH ACTIN
scope: SUBCELLULAR LOCATION
scope: DEVELOPMENTAL STAGE
scope: DISRUPTION PHENOTYPE

E2RU97-citation-26551337
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF THE UNPHOSPHORYLATED POLYGLYCYLATION MIMIC MUTANT AND IN COMPLEX WITH SYNTHETIC PHOSPHOPEPTIDE
scope: SUBUNIT
scope: BIOTECHNOLOGY

4F7R
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 3.20
chain sequence mapping: PDB 4F7R tt1tt248

PDB 4F7R tt1tt248
chain: A/B/C/D=1-248

4ZQ0
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 3.10
chain sequence mapping: PDB 4ZQ0 tt5tt238

PDB 4ZQ0 tt5tt238
chain: A/B/C/D=5-238

5BY9
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 4.00
chain sequence mapping: PDB 5BY9 tt1tt246

PDB 5BY9 tt1tt246
chain: A/B/C/D=1-246

cd08774
type: Resource
database: CDD
comment: 14-3-3
signature sequence match: CDD cd08774 match 1

http://purl.uniprot.org/gene3d/1.20.190.20
type: Resource
database: Gene3D
comment: 14-3-3 domain
signature sequence match: Gene3D 1.20.190.20 match 1

IPR000308
type: Resource
database: InterPro
comment: 14-3-3

IPR023409
type: Resource
database: InterPro
comment: 14-3-3_CS

IPR036815
type: Resource
database: InterPro
comment: 14-3-3_dom_sf

IPR023410
type: Resource
database: InterPro
comment: 14-3-3_domain

PTHR18860
type: Resource
database: PANTHER
comment: 14-3-3 PROTEIN
signature sequence match: PANTHER PTHR18860 match 1

PTHR18860:SF17
type: Resource
database: PANTHER
comment: 14-3-3 PROTEIN ZETA
signature sequence match: PANTHER PTHR18860:SF17 match 1

PF00244
type: Resource
database: Pfam
comment: 14-3-3
signature sequence match: Pfam PF00244 match 1

PIRSF000868
type: Resource
database: PIRSF
comment: 14-3-3
signature sequence match: PIRSF PIRSF000868 match 1

PR00305
type: Resource
database: PRINTS
comment: 1433ZETA

SM00101
type: Resource
database: SMART
comment: 14_3_3
signature sequence match: SMART SM00101 match 1

SSF48445
type: Resource
database: SUPFAM
comment: 14-3-3 protein
signature sequence match: SUPFAM SSF48445 match 1

PS00796
type: Resource
database: PROSITE
comment: 1433_1
signature sequence match: PROSITE PS00796 match 1

SIPB80C1032135BFDE2
type: Structured Name
full name: 14-3-3 protein

SIPE61005D5558A6D92
type: Structured Name
full name: GI-14-3-3

SIP44606DD3F01BDF3C
type: Structured Name
full name: g14-3-3

http://purl.uniprot.org/uniprot/E2RU97#gene-MD5026DCD98573A75B6CA3F1CFF350D0543
type: Gene
orf name: GL50803_006430
orf name: GL50803_6430

SIP01AEB8314B46F75F
type: Function Annotation
comment: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Binds with varying affinity to various synthetic phosphopeptides having a consensus binding motif RSX(pS/pT)XP, called mode-1, where X is any residue and pS/pT is a phosphorylated serine/threonine, and to synthetic phosphopeptides having a consensus binding motif Xp(S/T)X1-2-COOH, called mode-3, in which the phosphorylated residue occupies the penultimate C-terminal position in the target protein, but does not bind to their unphosphorylated counterparts (PubMed:19733174). Binds to synthetic human RAF1 phosphopeptides, but not to their unphosphorylated forms. Binds to difopein, a polypeptide containing a phosphorylation-independent binding motif (PubMed:16368691, PubMed:19733174). Involved in encystation (PubMed:19733174). Involved in cell proliferation. Required for actin and tubulin cytoskeletal organization. Regulates actin filament formation and nuclear size (PubMed:28932813).

SIPC51AF7614BAF32D6
type: Subunit Annotation
comment: Homodimer (PubMed:16368691, PubMed:24658679, PubMed:28932813, PubMed:26551337, PubMed:22452640). Homodimerizes via N-terminal domains (PubMed:24658679, PubMed:26551337). Oligomerizes forming homotrimers, homotetramers and protein filaments. Oligomerization is hindered by polyglycylation in vivo (PubMed:24658679). Interacts with a large number of both cytosolic and membrane proteins in trophozoites and encysting parasites (PubMed:16368691, PubMed:22452640). Interacts with a serine/threonine protein kinase GL50803_112076 (gCDC7). Component of a multiprotein complex containing gCDC7 and GL50803_94117 (gDBF4), a regulatory subunit of gCDC7, during both the trophozoite and encysting stages of the parasite. Interacts with fructose-bisphosphate aldolase GL50803_11043 (gFBA), pyruvate kinase GL50803_17143 (gPyk), acetyl-CoA synthetase GL50803_13608 (gACS), protein kinase GL50803_22165 (gSTE), DEAD box RNA helicase GL50803_34684 (gVASA) and Golgi/cell cycle associated protein GL50803_17472 (gGCCA) (PubMed:22452640). Interacts with actin (PubMed:24728194, PubMed:28932813). Interacts with both monomeric phosphorylated and unphosphorylated actin. The interaction is enhanced by phosphorylation of actin and inhibited by Rho GTPase Rac (PubMed:28932813).

SIP1795377CB3A9E2B0
type: Subcellular Location Annotation
comment: In trophozoites and cysts, localizes intensely in the cytoplasm. Not detected in the central area of the cell corresponding to the median body nor in flagella. Detected in the nuclei of the encysting cells. Nuclear localization increases during the transition of cells from the early to the late encysting stage. Does not localize to the encystation-specific vesicles of the encysting cells (PubMed:16368691, PubMed:19733174). In interphase cells, detected throughout the cell with somewhat enriched at the cortex and perinuclear region. Associates with the intracytoplasmic axonemes of all flagella, but it is most apparent in the anterior flagella of interphase cells. Localizes also to the nuclear envelope/endoplasmic reticulum and to the microtubule bare area of the ventral disc during interphase. In mitotic cells, disassociates from the intracytoplasmic axonemes and localizes around the spindle. During cytokinesis, localizes with the ingressing furrow, which does not utilize a contractile ring (PubMed:28932813). Does no colocalize with F-actin (PubMed:24728194, PubMed:28932813).
located in: SIPB94B67F8C7D3DFE6
located in: SIPD161F9B41A48BDCC
located in: SIPCE875355E9EB47FB
located in: SIP745D311E93869A6D
located in: SIP4EBE505D54128642
located in: SIP804E1BC5A5596611
located in: SIP9F2370CFB111013E

SIPAD114ED96AC918E6
type: Developmental Stage Annotation
comment: Expressed during excystation, the differentiation from cyst to trophozoite (at protein level) (PubMed:19861170). Expressed in trophozoites (at protein level) (PubMed:24658679, PubMed:19733174, PubMed:24147113, PubMed:24728194, PubMed:28932813, PubMed:22452640, PubMed:23058231, PubMed:21135098). Highly expressed during encystation stage, the differentiation from trophozoite to cyst (at protein level) (PubMed:24658679, PubMed:19733174, PubMed:24147113, PubMed:22452640). Expressed in feces extracted cysts (at protein level) (PubMed:19861170, PubMed:23058231). Expression in them is significantly lower than in trophozoites (at protein level) (PubMed:23058231). Constitutively expressed throughout the life cycle (PubMed:16368691).

SIPB8087EF954557293
type: Induction Annotation
comment: By encystation.

SIP9CA7B40B1C42F35E
type: PTM Annotation
comment: Phosphorylated constitutively throughout the life cycle. Phosphorylation is very high in trophozoites and encysting cells of 12 hours (PubMed:16368691). Phosphorylated during excystation (PubMed:19861170). Phosphorylation promotes its binding to various target proteins and is critical for encystation process. Phosphorylation modification is not influenced by polyglycylation modification (PubMed:19733174).

SIP374A2556F0F88ACB
type: PTM Annotation
comment: Polyglycylated on a glutamate residue, resulting in polyglycine chain on the gamma-carboxyl group (PubMed:16368691, PubMed:24658679, PubMed:19733174, PubMed:24147113, PubMed:21135098). Polyglycylated by the tubulin--tyrosine ligase-like protein GL50803_8456 (gTTLL3). The polyglycine chain is shortened by metallopeptidases of the M20 family, namely dipeptidases GL50803_15832 (gDIP1) and GL50803_8407 (gDIP2) (PubMed:21135098). The length of the polyglycine chain is developmental stage-dependent. In trophozoites, glycine residues range from 10 to 31, with the greatest occurrence of 21 residues. In 12 hour encystation stage, glycine residues range from 6 to 22, with the greatest occurrence of 10 residues. The differential rate of polyglycylation/deglycylation during the encystation process regulates the intracellular localization of this protein. Relocalizes partially from the cytoplasm inside the nuclei following the shortening of the polyglycine chain in encysting cells (PubMed:16368691, PubMed:19733174). Polyglycylation modification is not influenced by phosphorylation modification (PubMed:19733174). Polyglycylation prevents oligomerization in vivo (PubMed:24658679).

SIPF0534E27DB61299D
type: Disruption Phenotype Annotation
comment: Knockdown with morpholino results in dramatically reduced parasite growth, accumulation of multinucleate cells, abnormal flagellar positioning, and polarity and cytokinesis defects. Overall cytoplasmic actin organization is disrupted with ectopic short actin filaments, however, nuclei are enlarged with actin filaments covering the width of the nuclei.

SIP69C2CBDFC94F20CC
type: Biotechnology Annotation
comment: This protein may be used to design small molecules that inhibit its interactions with the target proteins. The inhibitors could be used as drugs to treat giardiasis, a disease caused by this parasite.

SIPD7404D3B5B32D1C4
type: Annotation
comment: Despite sequential and structural similarity, is not a functional ortholog of Drosophila 14-3-3 protein epsilon.

SIP137C9840A972FD41
type: Similarity Annotation
comment: Belongs to the 14-3-3 family.

PRO_0000455962
type: Chain Annotation
comment: 14-3-3 protein
mass: 28576
range: 19477102591555374tt1tt248

19477102591555374tt1
type: Position
type: ExactPosition
position: 1
reference: E2RU97-1

19477102591555374tt248
type: Position
type: ExactPosition
position: 248
reference: E2RU97-1

19477102591555374tt13
type: Position
type: ExactPosition
position: 13
reference: E2RU97-1

19477102591555374tt33
type: Position
type: ExactPosition
position: 33
reference: E2RU97-1

19477102591555374tt91
type: Position
type: ExactPosition
position: 91
reference: E2RU97-1

19477102591555374tt111
type: Position
type: ExactPosition
position: 111
reference: E2RU97-1

SIPD2E8563C1B0190E7
type: Motif Annotation
comment: Putative polyglycylation target motif (T/G)X0-1(D/E)X1-3-G(D/E)X1-2(gE)2-4, where X is polar or negatively charged amino acid, and gE is polyglycylated glutamine
range: 19477102591555374tt237tt248

19477102591555374tt237
type: Position
type: ExactPosition
position: 237
reference: E2RU97-1

19477102591555374tt135
type: Position
type: ExactPosition
position: 135
reference: E2RU97-1

19477102591555374tt136
type: Position
type: ExactPosition
position: 136
reference: E2RU97-1

SIP32AE70EF65031D69
type: Site Annotation
comment: Interaction with phosphoserine
range: 19477102591555374tt53tt53

19477102591555374tt53
type: Position
type: ExactPosition
position: 53
reference: E2RU97-1

SIP537C0059F45983A6
type: Site Annotation
comment: Interaction with phosphoserine
range: 19477102591555374tt60tt60

19477102591555374tt60
type: Position
type: ExactPosition
position: 60
reference: E2RU97-1

SIP8AC0E453482B3106
type: Modified Residue Annotation
comment: Phosphothreonine
range: 19477102591555374tt214tt214

19477102591555374tt214
type: Position
type: ExactPosition
position: 214
reference: E2RU97-1

SIPC7A5440C6224020F
type: Modified Residue Annotation
comment: 5-glutamyl polyglycine
range: 19477102591555374tt246tt246

19477102591555374tt246
type: Position
type: ExactPosition
position: 246
reference: E2RU97-1

SIP83250CE8B8461DFA
type: Mutagenesis Annotation
comment: Loss or strongly decreased binding to synthetic human RAF1 phosphopeptides. Loss of binding to difopein.
substitution: E
range: 19477102591555374tt53tt53

SIPEF27A8C979AD41E4
type: Mutagenesis Annotation
comment: Loss of binding to difopein.
substitution: D
range: 19477102591555374tt183tt183

19477102591555374tt183
type: Position
type: ExactPosition
position: 183
reference: E2RU97-1

SIPA8411A617A8B39F4
type: Mutagenesis Annotation
comment: Increased oligomerization.
substitution: K
range: 19477102591555374tt200tt200

19477102591555374tt200
type: Position
type: ExactPosition
position: 200
reference: E2RU97-1

SIPDF3F64519C0941BE
type: Mutagenesis Annotation
comment: Slightly decreased oligomerization.
substitution: A
range: 19477102591555374tt208tt208

19477102591555374tt208
type: Position
type: ExactPosition
position: 208
reference: E2RU97-1

SIP85DA11298C8E515C
type: Mutagenesis Annotation
comment: Loss of phosphorylation by a protein kinase. No effect on subcellular localization. Dramatic decrease in the number of encysting parasites and cysts, but a large increase in the number of trophozoites. In encysting cells of 12 hours, significantly slower cyst conversion rate compared to the wild-type. No effect on binding to difopein. Decreased binding to a number of synthetic phosphopeptides.
substitution: A
range: 19477102591555374tt214tt214

SIP7CCA523F2C98B21B
type: Mutagenesis Annotation
comment: Phosphomimetic mutant. No effect on oligomerization. No effect on binding to difopein. Altered binding intensity or capability to various synthetic phosphopeptides.
substitution: E
range: 19477102591555374tt214tt214

SIP78C1FF90A603B893
type: Mutagenesis Annotation
comment: Loss of polyglycylation. In trophozoites, encysting cells and cysts, localizes to the nuclei in addition to the cytoplasm. Increased encystation and increased number of cysts. In encysting cells of 12 hours, significantly faster cyst conversion rate compared to the wild-type.
substitution: A
range: 19477102591555374tt246tt246

SIPB2827E98EFB86C6F
type: Mutagenesis Annotation
comment: No effect on polyglycylation.
substitution: A
range: 19477102591555374tt247tt247

19477102591555374tt247
type: Position
type: ExactPosition
position: 247
reference: E2RU97-1

SIP776BE94C7EA77319
type: Mutagenesis Annotation
comment: Prevention of oligomerization and filament formation by the polyglycylation of E-246; when associated with K-248 del.
range: 19477102591555374tt247tt247

SIP4FA8C88D9F9A66D8
type: Mutagenesis Annotation
comment: Prevention of oligomerization and filament formation by the polyglycylation of E-246; when associated with E-247 del.
range: 19477102591555374tt248tt248

19477102591555374tt7
type: Position
type: ExactPosition
position: 7
reference: E2RU97-1

19477102591555374tt19
type: Position
type: ExactPosition
position: 19
reference: E2RU97-1

19477102591555374tt23
type: Position
type: ExactPosition
position: 23
reference: E2RU97-1

19477102591555374tt34
type: Position
type: ExactPosition
position: 34
reference: E2RU97-1

19477102591555374tt36
type: Position
type: ExactPosition
position: 36
reference: E2RU97-1

19477102591555374tt38
type: Position
type: ExactPosition
position: 38
reference: E2RU97-1

19477102591555374tt42
type: Position
type: ExactPosition
position: 42
reference: E2RU97-1

19477102591555374tt75
type: Position
type: ExactPosition
position: 75
reference: E2RU97-1

19477102591555374tt76
type: Position
type: ExactPosition
position: 76
reference: E2RU97-1

19477102591555374tt78
type: Position
type: ExactPosition
position: 78
reference: E2RU97-1

19477102591555374tt81
type: Position
type: ExactPosition
position: 81
reference: E2RU97-1

19477102591555374tt113
type: Position
type: ExactPosition
position: 113
reference: E2RU97-1

19477102591555374tt116
type: Position
type: ExactPosition
position: 116
reference: E2RU97-1

19477102591555374tt120
type: Position
type: ExactPosition
position: 120
reference: E2RU97-1

19477102591555374tt138
type: Position
type: ExactPosition
position: 138
reference: E2RU97-1

19477102591555374tt143
type: Position
type: ExactPosition
position: 143
reference: E2RU97-1

19477102591555374tt164
type: Position
type: ExactPosition
position: 164
reference: E2RU97-1

19477102591555374tt172
type: Position
type: ExactPosition
position: 172
reference: E2RU97-1

19477102591555374tt187
type: Position
type: ExactPosition
position: 187
reference: E2RU97-1

19477102591555374tt192
type: Position
type: ExactPosition
position: 192
reference: E2RU97-1

19477102591555374tt209
type: Position
type: ExactPosition
position: 209
reference: E2RU97-1

19477102591555374tt210
type: Position
type: ExactPosition
position: 210
reference: E2RU97-1

19477102591555374tt212
type: Position
type: ExactPosition
position: 212
reference: E2RU97-1

19477102591555374tt218
type: Position
type: ExactPosition
position: 218
reference: E2RU97-1

19477102591555374tt235
type: Position
type: ExactPosition
position: 235
reference: E2RU97-1

E2RU97-1
type: Simple Sequence
modified: 2010-11-30
version: 1
mass: 28576
value: MAEAFTREDYVFMAQLNENAERYDEMVETMRKISGMEGELSDKERNLLSVAYKNVIGPRRAAWRIVSSIEAKEKGRQKPNAKRIEQIRVYRQKIEKELSDICNDILKLLQEQFVPRSTNADAKVFYYKMQGDYYRYLAEYSSGEDKEKIAGSALNAYNSAFEISQQLPPTHPIRLGLALNFSVFYYEILASPDRACELARKAFDAAITDLDKLTEESYKDSTLIMQLLRDNLNLWVTDSAGDDNAEEK

http://purl.uniprot.org/uniprot/E2RU97#attribution-FD08AF0E0F648149672E56BD290901D4
creator: UniProtKB
manual: true
evidence: ECO_0000314
source: http://purl.uniprot.org/citations/28932813

http://purl.uniprot.org/uniprot/E2RU97#attribution-A0317EEDB5FBC7B48FF8D11CFA8883CA
creator: UniProtKB
manual: true
evidence: ECO_0000314
source: http://purl.uniprot.org/citations/16368691

http://purl.uniprot.org/uniprot/E2RU97#attribution-A8DD0998E6B6EE3110A0E2D2FB724E7C
creator: UniProtKB
manual: true
evidence: ECO_0000314
source: http://purl.uniprot.org/citations/19733174

http://purl.uniprot.org/uniprot/E2RU97#attribution-71F120675539320C47E69D511152544C
creator: UniProtKB
manual: true
evidence: ECO_0000314
source: http://purl.uniprot.org/citations/19861170

http://purl.uniprot.org/uniprot/E2RU97#attribution-30A4F3A5FE55182FD9D51FFB79C41272
creator: UniProtKB
manual: true
evidence: ECO_0000314
source: http://purl.uniprot.org/citations/21135098

http://purl.uniprot.org/uniprot/E2RU97#attribution-8F97188A359F27B1250369F4258A5C0F
creator: UniProtKB
manual: true
evidence: ECO_0000314
source: http://purl.uniprot.org/citations/24147113

http://purl.uniprot.org/uniprot/E2RU97#attribution-B9E656E6F02B390614F57A82FF7A9BDE
creator: UniProtKB
manual: true
evidence: ECO_0000314
source: http://purl.uniprot.org/citations/24728194

http://purl.uniprot.org/uniprot/E2RU97#attribution-F63188C7916840D89680593EF4F6F791
creator: UniProtKB
manual: true
evidence: ECO_0000314
source: http://purl.uniprot.org/citations/22452640

http://purl.uniprot.org/uniprot/E2RU97#attribution-86D716013F9218BE5F2522EE53EB0E68
creator: UniProtKB
manual: true
evidence: ECO_0000314
source: http://purl.uniprot.org/citations/24658679

http://purl.uniprot.org/uniprot/E2RU97#attribution-EB226C93EAAA64B274D7C3F1E46917D3
creator: UniProtKB
manual: true
evidence: ECO_0000314
source: http://purl.uniprot.org/citations/26551337

http://purl.uniprot.org/uniprot/E2RU97#attribution-5E8C4EEB1E5C407CB6A7886CD57FC627
creator: UniProtKB
manual: true
evidence: ECO_0000353
source: http://purl.uniprot.org/citations/22452640

http://purl.uniprot.org/uniprot/E2RU97#attribution-41CF6F47A5FF80A0719EDDF59437FB80
creator: UniProtKB
manual: true
evidence: ECO_0000315
source: http://purl.uniprot.org/citations/28932813

http://purl.uniprot.org/uniprot/E2RU97#attribution-68097C5C9D39FEEE8BE013645ACBBDD4
creator: UniProtKB
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/E2RU97#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/E2RU97#attribution-533E32B358F085BF8EF6ADBB91A690C7
manual: true
evidence: ECO_0000250
source: P62261

http://purl.uniprot.org/uniprot/E2RU97#attribution-72E7DE4143AD864A69B5AB4C8C208CEB
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/E2RU97#attribution-3022C962C1D058DE6816BDF14C828367
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/16368691

http://purl.uniprot.org/uniprot/E2RU97#attribution-D03C5F7BDCA2568BC25565FB71233750
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/19733174

http://purl.uniprot.org/uniprot/E2RU97#attribution-8A3EA132523731B29D847DFC18B6E80B
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/19861170

http://purl.uniprot.org/uniprot/E2RU97#attribution-C6C8CBC3043A0614DB590ECE25D34702
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/21135098

http://purl.uniprot.org/uniprot/E2RU97#attribution-EB24BFCD8BA6D616F845566C5A761CEB
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/22452640

http://purl.uniprot.org/uniprot/E2RU97#attribution-3A9D882362C0FF8AEC584EB490FF170A
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/23058231

http://purl.uniprot.org/uniprot/E2RU97#attribution-D36AF3AF0FCA7210BFEAB1588BE22538
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/24147113

http://purl.uniprot.org/uniprot/E2RU97#attribution-A2D8B9C3A5DA68C2AED02D1CAF7B5801
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/24658679

http://purl.uniprot.org/uniprot/E2RU97#attribution-E6E3FB1E13C620C89A360C93BE2C9A3C
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/24728194

http://purl.uniprot.org/uniprot/E2RU97#attribution-EE67FFAE7E8802AE1BD2A60F00B8C411
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/26551337

http://purl.uniprot.org/uniprot/E2RU97#attribution-A33D0BE18294350A11D3ACABA66BF425
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/28932813

http://purl.uniprot.org/uniprot/E2RU97#attribution-14782F6C491AFAA177BB5E2F3291552D
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/16368691

http://purl.uniprot.org/uniprot/E2RU97#attribution-09B9A94BA622FF387FADF39C0B620635
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/19733174

http://purl.uniprot.org/uniprot/E2RU97#attribution-9EC601059D9E7D7BF307D69908343640
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/19861170

http://purl.uniprot.org/uniprot/E2RU97#attribution-95FF3BDEAF864A258FAFAF50E5ACF3D2
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/21135098

http://purl.uniprot.org/uniprot/E2RU97#attribution-4516296269D90A18216202F85DF0DE98
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/22452640

http://purl.uniprot.org/uniprot/E2RU97#attribution-75D783CD71D8BCAA33FF315D8C11F6D0
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/24147113

http://purl.uniprot.org/uniprot/E2RU97#attribution-D2399F19F4F8339E198E4F6BDEC9E4F8
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/24658679

http://purl.uniprot.org/uniprot/E2RU97#attribution-F56166936363D3D133E4DDA4AADAF0DC
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/24728194

http://purl.uniprot.org/uniprot/E2RU97#attribution-D69592B787D5F39712F39170A025B57D
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/26551337

http://purl.uniprot.org/uniprot/E2RU97#attribution-9BB1EB51DCE5413068E19B8C9A5893BB
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/28932813

http://purl.uniprot.org/uniprot/E2RU97#attribution-5CFFBD7318828D1DC0DC960F44E82F16
manual: true
evidence: ECO_0000305

http://purl.uniprot.org/uniprot/E2RU97#attribution-FF7B7C82058E492DCF27BD380219A614
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/26551337

http://purl.uniprot.org/uniprot/E2RU97#attribution-AD3EB9E5B856A8D63A9C1896B0E7E2ED
manual: true
evidence: ECO_0000312
source: AAZ91664.1

http://purl.uniprot.org/uniprot/E2RU97#attribution-58C180C591A11467B1010D0804796E8A
manual: true
evidence: ECO_0000312
source: EDO79081.1

http://purl.uniprot.org/uniprot/E2RU97#attribution-424342812103A0869F715C00D59EEF1F
manual: true
evidence: ECO_0000312
source: KAE8304865.1

http://purl.uniprot.org/uniprot/E2RU97#attribution-1B3CCBDFECC756B2140524B817A3D5E5
manual: true
evidence: ECO_0000312
source: UP000001548

http://purl.uniprot.org/uniprot/E2RU97#attribution-5EE0315D6EBFA7D17A3DA40C4C266FF8
manual: true
evidence: ECO_0007744
source: 4F7R

http://purl.uniprot.org/uniprot/E2RU97#attribution-A754A84F147AB228B466E87423D80E3B
manual: true
evidence: ECO_0007744
source: 4ZQ0

http://purl.uniprot.org/uniprot/E2RU97#attribution-4AA1939EF790D96E901451DCDC53A271
manual: true
evidence: ECO_0007744
source: 5BY9

P33405
type: Protein
reviewed: true
created: 1994-02-01
modified: 2019-12-11
version: 27
mnemonic: 28KD_TRIFO
citation: http://purl.uniprot.org/citations/8319888
recommended name: SIP550108F2D898F535
organism: http://purl.uniprot.org/taxonomy/56690
annotation: SIPA276E8D0F51C5514
annotation: PRO_0000064357
annotation: SIP1EDB641C0BC01D56
annotation: SIPA3B1813B4740BF7E
annotation: SIPC2F8A684E4A265B2
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/903
sequence: ARYAILFAGSNVVYNAXXQADIYTIYTFL

P33405-citation-8319888
type: Citation Statement
scope: PROTEIN SEQUENCE

SIP550108F2D898F535
type: Structured Name
full name: 28 kDa protein

SIPA276E8D0F51C5514
type: Annotation
comment: Binds to bacitracin.

PRO_0000064357
type: Chain Annotation
comment: 28 kDa protein
mass: 3281
range: 22574293148775726tt1tf29

22574293148775726tt1
type: Position
type: ExactPosition
position: 1
reference: ARYAILFAGSNVVYNAXXQADIYTIYTFL

22574293148775726tt29
type: Position
type: ExactPosition
position: 29
reference: ARYAILFAGSNVVYNAXXQADIYTIYTFL

SIP1EDB641C0BC01D56
type: Sequence Uncertainty Annotation
comment: V or Y
range: 22574293148775726tt12tt12

22574293148775726tt12
type: Position
type: ExactPosition
position: 12
reference: ARYAILFAGSNVVYNAXXQADIYTIYTFL

SIPA3B1813B4740BF7E
type: Sequence Uncertainty Annotation
comment: V or W
range: 22574293148775726tt13tt13

22574293148775726tt13
type: Position
type: ExactPosition
position: 13
reference: ARYAILFAGSNVVYNAXXQADIYTIYTFL

ARYAILFAGSNVVYNAXXQADIYTIYTFL
type: Simple Sequence
modified: 1994-02-01
version: 1
fragment: single
mass: 3281

P51775
type: Protein
reviewed: true
created: 1996-10-01
modified: 2023-06-28
version: 78
mnemonic: ACT_GIAIN
old mnemonic: ACT_GIALA
citation: http://purl.uniprot.org/citations/8587128
recommended name: SIP7CC17EDC98B1D515
enzyme: http://purl.uniprot.org/enzyme/3.6.4.-
organism: http://purl.uniprot.org/taxonomy/5741
annotation: SIP3AE1591F837BCD4D
annotation: SIP3D3439F60AB1212C
annotation: SIPA521BE2741E570B6
annotation: SIP37038A431A9AB5EF
annotation: PRO_0000088944
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/206
classified with: http://purl.uniprot.org/keywords/378
classified with: GO_0005737
classified with: GO_0005856
classified with: GO_0005524
classified with: GO_0016787
sequence: P51775-1

P51775-citation-8587128
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

KOG0676
type: Resource
database: eggNOG
comment: Eukaryota

cd00012
type: Resource
database: CDD
comment: NBD_sugar-kinase_HSP70_actin
signature sequence match: CDD cd00012 match 1

IPR004000
type: Resource
database: InterPro
comment: Actin

IPR020902
type: Resource
database: InterPro
comment: Actin/actin-like_CS

IPR004001
type: Resource
database: InterPro
comment: Actin_CS

IPR043129
type: Resource
database: InterPro
comment: ATPase_NBD

PTHR11937
type: Resource
database: PANTHER
comment: ACTIN
signature sequence match: PANTHER PTHR11937 match 1

PTHR11937:SF387
type: Resource
database: PANTHER
comment: ACTIN
signature sequence match: PANTHER PTHR11937:SF387 match 1

PF00022
type: Resource
database: Pfam
comment: Actin
signature sequence match: Pfam PF00022 match 1

PR00190
type: Resource
database: PRINTS
comment: ACTIN

SM00268
type: Resource
database: SMART
comment: ACTIN
signature sequence match: SMART SM00268 match 1

SSF53067
type: Resource
database: SUPFAM
comment: Actin-like ATPase domain
signature sequence match: SUPFAM SSF53067 match 1
signature sequence match: SUPFAM SSF53067 match 2

PS00406
type: Resource
database: PROSITE
comment: ACTINS_1
signature sequence match: PROSITE PS00406 match 1

PS01132
type: Resource
database: PROSITE
comment: ACTINS_ACT_LIKE
signature sequence match: PROSITE PS01132 match 1

SIP7CC17EDC98B1D515
type: Structured Name
full name: Actin
ec name: 3.6.4.-

SIP3AE1591F837BCD4D
type: Function Annotation
comment: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

SIP37038A431A9AB5EF
type: Similarity Annotation
comment: Belongs to the actin family.

PRO_0000088944
type: Chain Annotation
comment: Actin
mass: 41586
range: 22576483632887086tt1tt375

22576483632887086tt1
type: Position
type: ExactPosition
position: 1
reference: P51775-1

22576483632887086tt375
type: Position
type: ExactPosition
position: 375
reference: P51775-1

P51775-1
type: Simple Sequence
modified: 1996-10-01
version: 1
mass: 41586
value: MTDDNPAIVIDNGSGMCKAGFAGDDAPRAVFPTVVGRPKRETVLVGSTHKEEYIGDEALAKRGVLKLSYPIEHGQIKDWDMMEKVWHHCYFNELRAQPSDHAVLLTEAPKNPKANREKICQIMFETFAVPAFYVQVQAVLALYSSGRTTGIVIDTGDGVTHTVPVYEGYSLPHAVLRSEIAGKELTDFCQINLQENGASFTTSAEFEIVRDIKEKLCFVALDYESVLAASMESANYTKTYELPDGVVITVNQARFKTPELLFRPELNNSDMDGIHQLCYKTIQKCDIDIRSELYSNVVLSGGSSMFAGLPERLEKELLDLIPAGKRVRISSPEDRKYSAWVGGSVLGSLATFESMWVSSQEYQENGASIANRKCM

http://purl.uniprot.org/uniprot/P51775#attribution-34D1610EF41644C907FC0B772132761B
manual: true
evidence: ECO_0000250
source: Q8I4X0

http://purl.uniprot.org/uniprot/P51775#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

C6LTG5
type: Protein
reviewed: true
created: 2011-02-08
modified: 2023-05-03
version: 43
mnemonic: AGO_GIAIB
citation: http://purl.uniprot.org/citations/19696920
recommended name: SIP5727DEA79A182CF5
organism: http://purl.uniprot.org/taxonomy/598745
annotation: SIP9566392D30238AEC
annotation: SIP8D3F0FB4EEEE1647
annotation: SIP4CCFB9A780E7AB1C
annotation: SIP985665A6C823B50F
annotation: SIP1299C86CD05D051D
annotation: PRO_0000405234
annotation: SIP8D1F8359FD80C00E
annotation: SIPFC97A9950ED2DAE3
annotation: SIPAB68D16CC15A9050
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/217
classified with: http://purl.uniprot.org/keywords/221
classified with: http://purl.uniprot.org/keywords/694
classified with: http://purl.uniprot.org/keywords/943
classified with: http://purl.uniprot.org/keywords/810
classified with: GO_0005737
classified with: GO_0003723
classified with: GO_0030154
classified with: GO_0006417
classified with: GO_0031047
sequence: C6LTG5-1
proteome: Unassembled WGS sequence

C6LTG5-citation-19696920
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 50581 / GS clone H7
type: Strain

http://purl.uniprot.org/gene3d/2.170.260.10
type: Resource
database: Gene3D
comment: paz domain
signature sequence match: Gene3D 2.170.260.10 match 1

http://purl.uniprot.org/gene3d/3.30.420.10
type: Resource
database: Gene3D
comment: Ribonuclease H-like superfamily/Ribonuclease H
signature sequence match: Gene3D 3.30.420.10 match 1

IPR003165
type: Resource
database: InterPro
comment: Piwi

IPR012337
type: Resource
database: InterPro
comment: RNaseH-like_sf

IPR036397
type: Resource
database: InterPro
comment: RNaseH_sf

PTHR22891:SF174
type: Resource
database: PANTHER
comment: ARGONAUTE-1, ISOFORM A
signature sequence match: PANTHER PTHR22891:SF174 match 1

PTHR22891
type: Resource
database: PANTHER
comment: EUKARYOTIC TRANSLATION INITIATION FACTOR 2C
signature sequence match: PANTHER PTHR22891 match 1

PF02171
type: Resource
database: Pfam
comment: Piwi
signature sequence match: Pfam PF02171 match 1

SM00950
type: Resource
database: SMART
comment: Piwi
signature sequence match: SMART SM00950 match 1

SSF53098
type: Resource
database: SUPFAM
comment: Ribonuclease H-like
signature sequence match: SUPFAM SSF53098 match 1

PS50821
type: Resource
database: PROSITE
comment: PAZ
signature sequence match: PROSITE PS50821 match 1

PS50822
type: Resource
database: PROSITE
comment: PIWI
signature sequence match: PROSITE PS50822 match 1

SIP5727DEA79A182CF5
type: Structured Name
full name: Protein argonaute

Ago
type: Gene
orf name: GL50581_2062

SIP9566392D30238AEC
type: Function Annotation
comment: Plays an essential role in growth and, with Dicer, also involved in microRNA (miRNA)-mediated translational repression. The RNA interference pathway is implicated in antigenic variation having a role in regulation of variant-specific surface protein (VSP)-coding gene expression. Several VSP genes are transcribed but only transcripts encoding the VSP to be expressed accumulate. Antisense RNAs corresponding to the silenced VSP genes are detected (By similarity).

SIP8D3F0FB4EEEE1647
type: Subunit Annotation
comment: Interacts with miR2. Highly specific binding to the mRNA m7G-cap. May be a component of the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger (By similarity).

SIP985665A6C823B50F
type: Domain Annotation
comment: PAZ domain is absent, but Ago is capable of binding small RNAs in the same way as the other Argonaute proteins.

SIP1299C86CD05D051D
type: Similarity Annotation
comment: Belongs to the argonaute family. Ago subfamily.

PRO_0000405234
type: Chain Annotation
comment: Protein argonaute
mass: 100571
range: 18918524898981166tt1tt899

18918524898981166tt1
type: Position
type: ExactPosition
position: 1
reference: C6LTG5-1

18918524898981166tt899
type: Position
type: ExactPosition
position: 899
reference: C6LTG5-1

SIP8D1F8359FD80C00E
type: Domain Extent Annotation
comment: PAZ
range: 18918524898981166tt229tt313

18918524898981166tt229
type: Position
type: ExactPosition
position: 229
reference: C6LTG5-1

18918524898981166tt313
type: Position
type: ExactPosition
position: 313
reference: C6LTG5-1

SIPFC97A9950ED2DAE3
type: Domain Extent Annotation
comment: Piwi
range: 18918524898981166tt555tt878

18918524898981166tt555
type: Position
type: ExactPosition
position: 555
reference: C6LTG5-1

18918524898981166tt878
type: Position
type: ExactPosition
position: 878
reference: C6LTG5-1

SIPAB68D16CC15A9050
type: Region Annotation
comment: Disordered
range: 18918524898981166tt107tt129

18918524898981166tt107
type: Position
type: ExactPosition
position: 107
reference: C6LTG5-1

18918524898981166tt129
type: Position
type: ExactPosition
position: 129
reference: C6LTG5-1

C6LTG5-1
type: Simple Sequence
modified: 2009-09-22
version: 1
mass: 100571
value: MTTDIVTSRINFYPYTVLPSAKPVYQYDLSIQVSTQGYNLDNADSYRALEKFCEQQDTALGNDPARSLFYSLIVDFPSSDSRPISSFYSQTDLGSRPVTHTVEFLSTQKPKRRGGRAGGMRGNRGGPSTTSVQALVKVTRVRQMDPLDLMSMKTLLNILLRRTFESSLGMLNIRSGFYDLNRTSTHNIQVDGRGFDICWIPGFRLTTATLYGKLGLQVLPETTKVRSKSMCELLNENRGSLHPNALAAITVMAMHNGRVFRIHSIVRGQSVVSPLAEGSDTDYFTYYSAKYKDKIDSAALSLLKQDDYCNSVLQRDKFILKLTPLKKTHNGKVVRSCNVPSSLCIIISDNEIAPYGVSKLSTNKTAVALSTMSPDALLEKATEFANQLIDNAELQSVLGDYGFRFTSQPLELDTFVCKPPKLMMDTLSRELTVEDDSGGVFRSLIQSPGVSSIYYANNGQPAVGMPHWALMVPRYLKNDYARRLKQELTQRIRSLAGATASTVEEPLLIAVDVNEQRRDMYRIEPYKDAFESLLVKLNTQYPDTKNSELISRIQLVVVVIPGPKQYSGGLYKEVKRFYTDKGIVTQCLLTPRLSRDGPEWYDQAILNGLCQQIYAKAGGAVWAPALPKDNAYSTSTMLCALDVSRPKKTVGRPTEVPASTAGFISTYEGSFEYIYSQKKNLMPNRLNQGGEVQQQTLMKTFIKNSCEVYSAFNSSLPDRIVIFRDGVSDGQISTVLETEINSLYEYLCQRYREANRPMCDLKVIVAQKTCAMRLAAVSNTDLRPGFYILNHSPDNKQKGSEFIMASQAIVHGTTPKPIRYKLIFDSTEASMDNSSFKQLIELTNTMAYGYVNWPQAISLPHILHMAHLLSKFCGEILGNGRDLLESQAIFGLQYRPFFI

http://purl.uniprot.org/uniprot/C6LTG5#attribution-0D098C480630E7E2085125F49566A32C
manual: true
evidence: ECO_0000250
source: Q86QW7

http://purl.uniprot.org/uniprot/C6LTG5#attribution-3D45A364DB79282ACEEFD6F3011DAF50
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/C6LTG5#attribution-09A40CD9DF3A0077F104F85851E2A9BD
manual: true
evidence: ECO_0000255
source: PRU00142

http://purl.uniprot.org/uniprot/C6LTG5#attribution-3EB2E10C8089501396251CB0CEECFF72
manual: true
evidence: ECO_0000255
source: PRU00150

http://purl.uniprot.org/uniprot/C6LTG5#attribution-1F307A4EAC5F25B2FB5319E5ED45F9F3
manual: true
evidence: ECO_0000312
source: EET00696.1

A8BCK6
type: Protein
reviewed: true
created: 2011-02-08
modified: 2023-06-28
version: 57
mnemonic: AGO_GIAIC
citation: http://purl.uniprot.org/citations/17901334
recommended name: SIP5727DEA79A182CF5
organism: http://purl.uniprot.org/taxonomy/184922
annotation: SIP6DFD83C404249345
annotation: SIPE2AB8D073A36F98C
annotation: SIPE5AC27A9198CF8AA
annotation: SIP7BFCF15496E65EBB
annotation: SIP8BDA04FC0CABB41A
annotation: PRO_0000405235
annotation: SIP19BCD8AFAA6152CC
annotation: SIP7F820B7D90A71E0A
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/217
classified with: http://purl.uniprot.org/keywords/221
classified with: http://purl.uniprot.org/keywords/694
classified with: http://purl.uniprot.org/keywords/943
classified with: http://purl.uniprot.org/keywords/810
classified with: GO_0005737
classified with: GO_0003723
classified with: GO_0030154
classified with: GO_0006417
classified with: GO_0031047
sequence: A8BCK6-1

A8BCK6-citation-17901334
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 50803 / WB clone C6
type: Strain

SIP5727DEA79A182CF5
type: Structured Name
full name: Protein argonaute

Ago
type: Gene
orf name: GL50803_2902

SIP6DFD83C404249345
type: Function Annotation
comment: Plays an essential role in growth and, with Dicer, also involved in microRNA (miRNA)-mediated translational repression. The RNA interference pathway is implicated in antigenic variation having a role in regulation of variant-specific surface protein (VSP)-coding gene expression. Several VSP genes are transcribed but only transcripts encoding the VSP to be expressed accumulate. Antisense RNAs corresponding to the silenced VSP genes are detected (By similarity).

SIPE2AB8D073A36F98C
type: Subunit Annotation
comment: Interacts with miR2. Highly specific binding to the mRNA m7G-cap. May be a component of the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger (By similarity).

SIP7BFCF15496E65EBB
type: Domain Annotation
comment: PAZ domain is absent, but Ago is capable of binding small RNAs in the same way as the other Argonaute proteins.

SIP8BDA04FC0CABB41A
type: Similarity Annotation
comment: Belongs to the argonaute family. Ago subfamily.

PRO_0000405235
type: Chain Annotation
comment: Protein argonaute
mass: 100817
range: 18357730734192174tt1tt900

18357730734192174tt1
type: Position
type: ExactPosition
position: 1
reference: A8BCK6-1

18357730734192174tt900
type: Position
type: ExactPosition
position: 900
reference: A8BCK6-1

SIP19BCD8AFAA6152CC
type: Domain Extent Annotation
comment: PAZ
range: 18357730734192174tt229tt313

18357730734192174tt229
type: Position
type: ExactPosition
position: 229
reference: A8BCK6-1

18357730734192174tt313
type: Position
type: ExactPosition
position: 313
reference: A8BCK6-1

SIP7F820B7D90A71E0A
type: Domain Extent Annotation
comment: Piwi
range: 18357730734192174tt555tt879

18357730734192174tt555
type: Position
type: ExactPosition
position: 555
reference: A8BCK6-1

18357730734192174tt879
type: Position
type: ExactPosition
position: 879
reference: A8BCK6-1

A8BCK6-1
type: Simple Sequence
modified: 2007-11-13
version: 1
mass: 100817
value: MVADVVTSRINFYPYTVLPSARPVYQYDLSIHISNQGYSLDNADSCRALERFCEQQDAALGNNLEHGLFYSLIIDFPSSDACPISSFYSQIDLGSRPITHTVEFLSTQKPRRRGGRVGGMRNNIAGPPITPVQATVKVTRVRQMDPTDLMSMKILLNILLRRTFESSLGMLNIRSGFYDLRNPSIHAIQIDGRGYDICWIPGFRLTTATLRGKLGLQILPETTKVRSKSMNELLTERRGNIHPSALAVITVMAMHNGKVFRVHSIVQGQTIVSPLANGNETDYFTYYSTRYRDKIDSAGLSLLRHNDYCNSVMQQDKFILKLTPLKRTQNGKVVRPCNVPSSLCIIISDNEIAPYGVSKLSTNRAAVALSTMSPDALLEKATAFAARLAEDTELQSLLGDYGFGFTSNPLELETFVCKPPKLMMDNTSRIVTIEDDSGGVFHNLLQSPGVSPIYYSNNNQPATGMPVWAIMVPRNLGNDYARRLRKELTERVRSLAGTTAPNIGDPPLIAVELSNQRREMYRVEPYKDAFKALLNKLRLEYKDARESEIVAKIQLVVIVIPGPKQDRGDLYKGIKQFYTHMGIVTQCLLAPKSSQNELQWYDQAVLRSVCQQIYAKAGGAVWAPVLPPQNVYSKSTMLCALDISRPKKTVGRPAEVPISTAGFISTYDGSFEYIYSQKKTLVPNRLNHGGELQQQTLMEAFIKNSCNVYLAFNNRILPDHIVIFRDGVSDSQISATLEVEIKSLYECLRQIYHKSNRPMCDLKVIVAQKTCAMRFSAVGGTVLRSGYYVINRSPDNRQQGSEFLMASQAIVHGTTPKPIRYKIIFDSMEASVDNDSFNQLIELTNAMAYGYVNWPQAISLPHVLHMAHHLSKFCGEVLRNGDDLFESCAIFGLQYRPFFI

http://purl.uniprot.org/uniprot/A8BCK6#attribution-0D098C480630E7E2085125F49566A32C
manual: true
evidence: ECO_0000250
source: Q86QW7

http://purl.uniprot.org/uniprot/A8BCK6#attribution-3D45A364DB79282ACEEFD6F3011DAF50
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/A8BCK6#attribution-09A40CD9DF3A0077F104F85851E2A9BD
manual: true
evidence: ECO_0000255
source: PRU00142

http://purl.uniprot.org/uniprot/A8BCK6#attribution-3EB2E10C8089501396251CB0CEECFF72
manual: true
evidence: ECO_0000255
source: PRU00150

http://purl.uniprot.org/uniprot/A8BCK6#attribution-BCDEB911A2ECAEEDC8A9735086DF20C8
manual: true
evidence: ECO_0000312
source: EDO80252.1

Q86QW7
type: Protein
reviewed: true
created: 2011-02-08
modified: 2023-06-28
version: 47
mnemonic: AGO_GIAIN
citation: http://purl.uniprot.org/citations/19079052
citation: http://purl.uniprot.org/citations/19043559
conflicting sequence: SIP2F444B2FCEA93574
recommended name: SIP96E87216EC75E19F
organism: http://purl.uniprot.org/taxonomy/5741
isolated from: http://purl.uniprot.org/tissues/1335
annotation: SIP1FD5FFB251C72A86
annotation: SIP85FBD615B9D8AF54
annotation: SIP99A3016A51D7931A
annotation: SIP89775A3EBFE89A3B
annotation: SIP3850DB6425400D12
annotation: SIP492E886A0E10445A
annotation: SIPA172CBDC0931EF43
annotation: PRO_0000405236
annotation: SIP8343044316A965F6
annotation: SIP913663E24D70ECAA
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/217
classified with: http://purl.uniprot.org/keywords/221
classified with: http://purl.uniprot.org/keywords/694
classified with: http://purl.uniprot.org/keywords/943
classified with: http://purl.uniprot.org/keywords/810
classified with: GO_0005737
classified with: GO_0003723
classified with: GO_0030154
classified with: GO_0006417
classified with: GO_0031047
sequence: Q86QW7-1

Q86QW7-citation-19079052
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: FUNCTION
scope: SUBUNIT
scope: SUBCELLULAR LOCATION
scope: DISRUPTION PHENOTYPE

ATCC 30957 / WB
type: Strain

WB1267
type: Strain

WB9B10
type: Strain

Q86QW7-citation-19043559
type: Citation Statement
scope: FUNCTION
scope: RNA-BINDING
scope: DISRUPTION PHENOTYPE

Trophozoite
type: Tissue

EMBL AAO17548.1
comment: Different initiation.

KOG1042
type: Resource
database: eggNOG
comment: Eukaryota

SIP96E87216EC75E19F
type: Structured Name
full name: Protein argonaute
short name: GlAgo

Ago
type: Gene

SIP1FD5FFB251C72A86
type: Function Annotation
comment: Plays an essential role in growth and, with Dicer, also involved in microRNA (miRNA)-mediated translational repression. The RNA interference pathway is implicated in antigenic variation having a role in regulation of variant-specific surface protein (VSP)-coding gene expression. Several VSP genes are transcribed but only transcripts encoding the VSP to be expressed accumulate. Antisense RNAs corresponding to the silenced VSP genes are detected.

SIP85FBD615B9D8AF54
type: Subunit Annotation
comment: Interacts with miR2. Highly specific binding to the mRNA m7G-cap. May be a component of the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger.

SIP89775A3EBFE89A3B
type: Domain Annotation
comment: PAZ domain is absent, but Ago is capable of binding small RNAs in the same way as the other Argonaute proteins.

SIP3850DB6425400D12
type: Disruption Phenotype Annotation
comment: Inhibited cell growth due to inhibition of translation initiation. A change from single to multiple VSP expression in individual parasites.

SIP492E886A0E10445A
type: Similarity Annotation
comment: Belongs to the argonaute family. Ago subfamily.

SIPA172CBDC0931EF43
type: Erroneous Initiation Annotation
comment: Truncated N-terminus.
conflicting sequence: SIP2F444B2FCEA93574

PRO_0000405236
type: Chain Annotation
comment: Protein argonaute
mass: 87540
range: 22861279057622830tt1tt781

22861279057622830tt1
type: Position
type: ExactPosition
position: 1
reference: Q86QW7-1

22861279057622830tt781
type: Position
type: ExactPosition
position: 781
reference: Q86QW7-1

SIP8343044316A965F6
type: Domain Extent Annotation
comment: PAZ
range: 22861279057622830tt110tt194

22861279057622830tt110
type: Position
type: ExactPosition
position: 110
reference: Q86QW7-1

22861279057622830tt194
type: Position
type: ExactPosition
position: 194
reference: Q86QW7-1

SIP913663E24D70ECAA
type: Domain Extent Annotation
comment: Piwi
range: 22861279057622830tt436tt760

22861279057622830tt436
type: Position
type: ExactPosition
position: 436
reference: Q86QW7-1

22861279057622830tt760
type: Position
type: ExactPosition
position: 760
reference: Q86QW7-1

Q86QW7-1
type: Simple Sequence
modified: 2011-02-08
version: 2
mass: 87540
value: MRNNIAGPPITPVQATVKVTRVRQMDPTDLMSMKILLNILLRRTFESSLGMLNIRSGFYDLRNPSIHAIQIDGRGYDICWIPGFRLTTATLRGKLGLQILPETTKVRSKSMNELLTERRGNIHPSALAVITVMAMHNGKVFRVHSIVQGQTIVSPLANGNETDYFTYYSTRYRDKIDSAGLSLLRHNDYCNSVMQQDKFILKLTPLKRTQNGKVVRPCNVPSSLCIIISDNEIAPYGVSKLSTNRAAVALSTMSPDALLEKATAFAARLAEDTELQSLLGDYGFGFTSNPLELETFVCKPPKLMMDNTSRIVTIEDDSGGVFHNLLQSPGVSPIYYSNNNQPATGMPVWAIMVPRNLGNDYARRLRKELTERVRSLAGTTAPNIGDPPLIAVELSNQRREMYRVEPYKDAFKALLNKLRLEYKDARESEIVAKIQLVVIVIPGPKQDRGDLYKGIKQFYTHMGIVTQCLLAPKSSQNELQWYDQAVLRSVCQQIYAKAGGAVWAPVLPPQNVYSKSTMLCALDISRPKKTVGRPAEVPISTAGFISTYDGSFEYIYSQKKTLVPNRLNHGGELQQQTLMEAFIKNSCNVYLAFNNRILPDHIVIFRDGVSDSQISATLEVEIKSLYECLRQIYHKSNRPMCDLKVIVAQKTCAMRFSAVGGTVLRSGYYVINRSPDNRQQGSEFLMASQAIVHGTTPKPIRYKIIFDSMEASVDNDSFNQLIELTNAMAYGYVNWPQAISLPHVLHMAHHLSKFCGEVLRNGDDLFESCAIFGLQYRPFFI

http://purl.uniprot.org/uniprot/Q86QW7#attribution-0DB23C79D6D905386021FA5C03A7D461
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/Q86QW7#attribution-09A40CD9DF3A0077F104F85851E2A9BD
manual: true
evidence: ECO_0000255
source: PRU00142

http://purl.uniprot.org/uniprot/Q86QW7#attribution-3EB2E10C8089501396251CB0CEECFF72
manual: true
evidence: ECO_0000255
source: PRU00150

http://purl.uniprot.org/uniprot/Q86QW7#attribution-0FBEC84C0550081E1ABB0F75C6BB5733
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/19043559

http://purl.uniprot.org/uniprot/Q86QW7#attribution-90030F3C1E673F397675D5977C3CFE9A
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/19079052

http://purl.uniprot.org/uniprot/Q86QW7#attribution-068BC2392D46E2B97B575ADCB5413F6D
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/19043559

http://purl.uniprot.org/uniprot/Q86QW7#attribution-42E9F15F8EF81CDF248EE2F22465861D
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/19079052

http://purl.uniprot.org/uniprot/Q86QW7#attribution-62BC12D87D1B6171698364F0AD7581E6
manual: true
evidence: ECO_0000305

http://purl.uniprot.org/uniprot/Q86QW7#attribution-64CFD4EC5180153CD908230C10CC5044
manual: true
evidence: ECO_0000312
source: AAO17548.1

A8B2U2
type: Protein
reviewed: true
created: 2023-05-03
modified: 2023-09-13
version: 72
mnemonic: ALF_GIAIC
replaces: O97447
citation: http://purl.uniprot.org/citations/9831644
citation: http://purl.uniprot.org/citations/17901334
citation: SIP2ED3068E824AFAA1
citation: http://purl.uniprot.org/citations/31409864
citation: http://purl.uniprot.org/citations/17166851
citation: http://purl.uniprot.org/citations/19236002
citation: http://purl.uniprot.org/citations/21333622
conflicting sequence: SIP4EA6B78F5BD71E9D
recommended name: SIP8CA918D393EC1268
alternative name: SIPF673F42B52E6AC49
enzyme: http://purl.uniprot.org/enzyme/4.1.2.13
organism: http://purl.uniprot.org/taxonomy/184922
annotation: SIP150A9C4604577A59
annotation: SIP65A40671DC8D6575
annotation: SIP5C0E10B18C937E68
annotation: SIPFC5572216B7AF1C8
annotation: SIP49DFD14A1555A508
annotation: SIPB88293E1E32F9A3E
annotation: SIP7F0F37E489AC9B61
annotation: SIPBC09B96FE39A9A79
annotation: SIP6CDFBEDD8E557D91
annotation: SIPD4E279CB07A67F90
annotation: PRO_0000457933
annotation: SIPD1AB13F616010AA9
annotation: SIP1C158AD30C563F30
annotation: SIP51391D5B3464443B
annotation: SIPF01B4A63E5307940
annotation: SIP177940E92BD68AF5
annotation: SIP0A4F062FFAEDBB14
annotation: SIPE6747AB763938492
annotation: SIP3D43D32B981D8B15
annotation: SIPCF634648AA52685C
annotation: SIPACE693A197B00E9C
annotation: SIP88BDF118D82B2DD0
annotation: SIPA76D88961D55E058
annotation: SIP84D997A65EF9CCD7
annotation: SIPB281B2F2B51F5163
annotation: SIP26D5A6EC9A56B66F
annotation: SIP1DFDB668BA929824
annotation: SIP4FA2B304E472E757
annotation: SIP7133FE6889F19DA7
annotation: SIP9A4FFBF5710B7B05
annotation: SIP4BA370674DFEA5EB
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/324
classified with: http://purl.uniprot.org/keywords/456
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/862
classified with: GO_0004332
classified with: GO_0008270
classified with: GO_0030388
classified with: GO_0006096
sequence: A8B2U2-1
proteome: Chromosome 3
proteome: Unassembled WGS sequence

A8B2U2-citation-9831644
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

ATCC 50803 / WB clone C6
type: Strain

A8B2U2-citation-17901334
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

SIP2ED3068E824AFAA1
type: Submission Citation
title: New Giardia intestinalis WB genome in near-complete chromosomes.
author: Xu F.
author: Jex A.
author: Svard S.G.
date: 2019-07
submitted to: EMBL/GenBank/DDBJ

A8B2U2-citation-SIP2ED3068E824AFAA1
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

A8B2U2-citation-31409864
type: Citation Statement
scope: CATALYTIC ACTIVITY
scope: BIOPHYSICOCHEMICAL PROPERTIES
scope: MUTAGENESIS OF ARG-259 AND ASP-278

A8B2U2-citation-17166851
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) IN COMPLEX WITH ZINC AND SUBSTRATE TRANSITION STATE ANALOG PHOSPHOGLYCOLOHYDROXAMATE
scope: FUNCTION
scope: CATALYTIC ACTIVITY
scope: COFACTOR
scope: BIOPHYSICOCHEMICAL PROPERTIES
scope: PATHWAY
scope: SUBUNIT
scope: DEVELOPMENTAL STAGE
scope: DISRUPTION PHENOTYPE
scope: ACTIVE SITE
scope: MUTAGENESIS OF ASP-83

WB clone 1267
type: Strain

A8B2U2-citation-19236002
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF WILD TYPE AND MUTANT ALA-83 IN COMPLEX WITH ZINC; FRUCTOSE 1,6-BISPHOSPHATE AND SUBSTRATE ANALOG TAGATOSE 1,6-BISPHOSPHATE
scope: FUNCTION
scope: CATALYTIC ACTIVITY
scope: COFACTOR
scope: ACTIVE SITE
scope: MUTAGENESIS OF ASP-255

A8B2U2-citation-21333622
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) IN COMPLEX WITH ZINC AND INHIBITOR
scope: CATALYTIC ACTIVITY
scope: COFACTOR

2ISV
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.30
chain sequence mapping: PDB 2ISV tt1tt323

PDB 2ISV tt1tt323
chain: A/B=1-323

2ISW
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 1.75
chain sequence mapping: PDB 2ISW tt1tt323

PDB 2ISW tt1tt323
chain: A/B=1-323

3GAK
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.90
chain sequence mapping: PDB 3GAK tt1tt323

PDB 3GAK tt1tt323
chain: A/B=1-323

3GAY
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 1.80
chain sequence mapping: PDB 3GAY tt1tt323

PDB 3GAY tt1tt323
chain: A/B=1-323

3GB6
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.00
chain sequence mapping: PDB 3GB6 tt1tt323

PDB 3GB6 tt1tt323
chain: A/B=1-323

3OHI
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.30
chain sequence mapping: PDB 3OHI tt1tt323

PDB 3OHI tt1tt323
chain: A/B=1-323

http://purl.uniprot.org/brenda/4.1.2.13
type: Resource
database: BRENDA
comment: 2401

cd00947
type: Resource
database: CDD
comment: TBP_aldolase_IIB
signature sequence match: CDD cd00947 match 1

http://purl.uniprot.org/gene3d/3.20.20.70
type: Resource
database: Gene3D
comment: Aldolase class I
signature sequence match: Gene3D 3.20.20.70 match 1

IPR013785
type: Resource
database: InterPro
comment: Aldolase_TIM

IPR000771
type: Resource
database: InterPro
comment: FBA_II

IPR011289
type: Resource
database: InterPro
comment: Fruc_bis_ald_class-2

TIGR00167
type: Resource
database: NCBIfam
comment: cbbA
signature sequence match: NCBIfam TIGR00167 match 1

TIGR01859
type: Resource
database: NCBIfam
comment: fruc_bis_ald
signature sequence match: NCBIfam TIGR01859 match 1

PTHR30304
type: Resource
database: PANTHER
comment: D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE
signature sequence match: PANTHER PTHR30304 match 1

PTHR30304:SF0
type: Resource
database: PANTHER
comment: D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE SUBUNIT GATY-RELATED
signature sequence match: PANTHER PTHR30304:SF0 match 1

PF01116
type: Resource
database: Pfam
comment: F_bP_aldolase
signature sequence match: Pfam PF01116 match 1

PIRSF001359
type: Resource
database: PIRSF
comment: F_bP_aldolase_II
signature sequence match: PIRSF PIRSF001359 match 1

SSF51569
type: Resource
database: SUPFAM
comment: Aldolase
signature sequence match: SUPFAM SSF51569 match 1

PS00806
type: Resource
database: PROSITE
comment: ALDOLASE_CLASS_II_2
signature sequence match: PROSITE PS00806 match 1

SIP8CA918D393EC1268
type: Structured Name
full name: Fructose-bisphosphate aldolase
short name: Glfba
short name: glFBPA
ec name: 4.1.2.13

SIPF673F42B52E6AC49
type: Structured Name
full name: Fructose-1,6-bisphosphate aldolase

fba
type: Gene
alternative label: FBPA
orf name: GL50803_0011043

SIP150A9C4604577A59
type: Function Annotation
comment: Plays a key role in glycolysis by catalyzing the cleavage of fructose 1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde 3-phosphate (PubMed:17166851). Does not cleave D-tagatose-1,6-bisphosphate (PubMed:17166851, PubMed:19236002).

SIP5C0E10B18C937E68
type: Cofactor Annotation
comment: Binds 1 Zn(2+) ion per subunit.
cofactor: CHEBI_29105

SIPFC5572216B7AF1C8
type: Kinetics Annotation
comment: kcat is 3.55 sec(-1) with fructose 1,6-bisphosphate as substrate (at pH 7.5 and 25 degrees Celsius) (PubMed:17166851). kcat is 4.3 sec(-1) with fructose 1,6-bisphosphate as substrate (PubMed:31409864).
measured affinity: 1.7 uM for fructose 1,6-bisphosphate (at pH 7.5 and 25 degrees Celsius)
measured affinity: 1.8 uM for fructose 1,6-bisphosphate

SIP49DFD14A1555A508
type: PH Dependence Annotation
comment: Optimum pH is 7.5.

SIP7F0F37E489AC9B61
type: Subunit Annotation
comment: Homodimer.

SIPBC09B96FE39A9A79
type: Developmental Stage Annotation
comment: Expressed in trophozoites (at protein level).

SIP6CDFBEDD8E557D91
type: Disruption Phenotype Annotation
comment: RNAi-mediated knockdown is lethal.

SIPD4E279CB07A67F90
type: Similarity Annotation
comment: Belongs to the class II fructose-bisphosphate aldolase family.

PRO_0000457933
type: Chain Annotation
comment: Fructose-bisphosphate aldolase
mass: 35214
range: 18357730449633838tt1tt323

18357730449633838tt1
type: Position
type: ExactPosition
position: 1
reference: A8B2U2-1

18357730449633838tt323
type: Position
type: ExactPosition
position: 323
reference: A8B2U2-1

SIPD1AB13F616010AA9
type: Active Site Annotation
comment: Proton donor
range: 18357730449633838tt83tt83

18357730449633838tt83
type: Position
type: ExactPosition
position: 83
reference: A8B2U2-1

18357730449633838tt50
type: Position
type: ExactPosition
position: 50
reference: A8B2U2-1

18357730449633838tt84
type: Position
type: ExactPosition
position: 84
reference: A8B2U2-1

18357730449633838tt178
type: Position
type: ExactPosition
position: 178
reference: A8B2U2-1

18357730449633838tt179
type: Position
type: ExactPosition
position: 179
reference: A8B2U2-1

18357730449633838tt182
type: Position
type: ExactPosition
position: 182
reference: A8B2U2-1

18357730449633838tt210
type: Position
type: ExactPosition
position: 210
reference: A8B2U2-1

18357730449633838tt211
type: Position
type: ExactPosition
position: 211
reference: A8B2U2-1

18357730449633838tt213
type: Position
type: ExactPosition
position: 213
reference: A8B2U2-1

18357730449633838tt253
type: Position
type: ExactPosition
position: 253
reference: A8B2U2-1

18357730449633838tt255
type: Position
type: ExactPosition
position: 255
reference: A8B2U2-1

18357730449633838tt256
type: Position
type: ExactPosition
position: 256
reference: A8B2U2-1

18357730449633838tt259
type: Position
type: ExactPosition
position: 259
reference: A8B2U2-1

18357730449633838tt280
type: Position
type: ExactPosition
position: 280
reference: A8B2U2-1

SIP1DFDB668BA929824
type: Mutagenesis Annotation
comment: Severe loss of catalytic activity.
substitution: A
range: 18357730449633838tt83tt83

SIP4FA2B304E472E757
type: Mutagenesis Annotation
comment: 9.4-fold reduction in substrate affinity and 50-fold reduction in catalytic affinity. Has some activity towards tagatose-1,6-bisphosphate.
substitution: A
range: 18357730449633838tt255tt255

SIP7133FE6889F19DA7
type: Mutagenesis Annotation
comment: 1.8-fold reduction in substrate affinity and 2.8-fold reduction in catalytic efficiency. 6-fold reduction in substrate affinity and 24-fold reduction in catalytic efficiency; when associated with A-278.
substitution: A
range: 18357730449633838tt259tt259

SIP9A4FFBF5710B7B05
type: Mutagenesis Annotation
comment: 159-fold reduction in substrate affinity and 2770-fold reduction in catalytic efficiency. 6-fold reduction in substrate affinity and 24-fold reduction in catalytic efficiency; when associated with A-259.
substitution: A
range: 18357730449633838tt278tt278

18357730449633838tt278
type: Position
type: ExactPosition
position: 278
reference: A8B2U2-1

SIP4BA370674DFEA5EB
type: Sequence Conflict Annotation
conflicting sequence: SIP4EA6B78F5BD71E9D
substitution: S
range: 18357730449633838tt129tt129

18357730449633838tt129
type: Position
type: ExactPosition
position: 129
reference: A8B2U2-1

SIP3BAF37F414AD6315
subclass of: CHEBI_29105
comment: catalytic

A8B2U2-1
type: Simple Sequence
modified: 2007-11-13
version: 1
mass: 35214
value: MPLCTLRQMLGEARKHKYGVGAFNVNNMEQIQGIMKAVVQLKSPVILQCSRGALKYSDMIYLKKLCEAALEKHPDIPICIHLDHGDTLESVKMAIDLGFSSVMIDASHHPFDENVRITKEVVAYAHARGVSVEAELGTLGGIEEDVQNTVQLTEPQDAKKFVELTGVDALAVAIGTSHGAYKFKSESDIRLAIDRVKTISDLTGIPLVMHGSSSVPKDVKDMINKYGGKMPDAVGVPIESIVHAIGEGVCKINVDSDSRMAMTGAIRKVFVEHPEKFDPRDYLGPGRDAITEMLIPKIKAFGSAGHAGDYKVVSLEEAKAWYK

http://purl.uniprot.org/uniprot/A8B2U2#attribution-90C95ABC98AEB83F775935D8069A308E
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/17166851

http://purl.uniprot.org/uniprot/A8B2U2#attribution-80E12E27D00413AF794884CB56A7AD82
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/19236002

http://purl.uniprot.org/uniprot/A8B2U2#attribution-6C577CE032B50AD7008681AEFF7AB952
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/21333622

http://purl.uniprot.org/uniprot/A8B2U2#attribution-7E64ED50D3D0101FD22B6A559F1D6729
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/31409864

http://purl.uniprot.org/uniprot/A8B2U2#attribution-E2CD894BFCE22236B4801571FCA0603D
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/17166851

http://purl.uniprot.org/uniprot/A8B2U2#attribution-F9789E5B174A2953F702CC6C13407D71
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/9831644

http://purl.uniprot.org/uniprot/A8B2U2#attribution-432D937040594224ED7331B46761B090
manual: true
evidence: ECO_0000305

http://purl.uniprot.org/uniprot/A8B2U2#attribution-6FAC349A113FF223D328D9651CD078B1
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/17166851

http://purl.uniprot.org/uniprot/A8B2U2#attribution-9B9F13BE4A6CE0E494F2F54631839B9A
manual: true
evidence: ECO_0000312
source: AAD05239.1

http://purl.uniprot.org/uniprot/A8B2U2#attribution-2F3D860653AEAEDBFD71823E895E7A36
manual: true
evidence: ECO_0000312
source: EDO82376.1

http://purl.uniprot.org/uniprot/A8B2U2#attribution-3BED72AAF579219C5EF5FA73265B2661
manual: true
evidence: ECO_0000312
source: KAE8303045.1

http://purl.uniprot.org/uniprot/A8B2U2#attribution-FC656AC3BDE80BCAC4E226869A3D3737
manual: true
evidence: ECO_0000312
source: UP000001548

http://purl.uniprot.org/uniprot/A8B2U2#attribution-D9B964C17EAC4490890998F4CC902559
manual: true
evidence: ECO_0007744
source: 2ISV

http://purl.uniprot.org/uniprot/A8B2U2#attribution-9632D3190F8D7D15C79EE91A912E289F
manual: true
evidence: ECO_0007744
source: 2ISW

http://purl.uniprot.org/uniprot/A8B2U2#attribution-30A17A230AAFFD6FB44CBD213897F20D
manual: true
evidence: ECO_0007744
source: 3GAK

http://purl.uniprot.org/uniprot/A8B2U2#attribution-D93A5DFF677F4170A56FF42912C2BAA5
manual: true
evidence: ECO_0007744
source: 3GAY

http://purl.uniprot.org/uniprot/A8B2U2#attribution-5BCA88333515E926B683B66F5E340CAF
manual: true
evidence: ECO_0007744
source: 3GB6

http://purl.uniprot.org/uniprot/A8B2U2#attribution-305A932B08678C274DCD068B2FFCB438
manual: true
evidence: ECO_0007744
source: 3OHI

A2DZE8
type: Protein
reviewed: true
created: 2015-01-07
modified: 2023-05-03
version: 65
mnemonic: ALG5A_TRIV3
old mnemonic: ALG5A_TRIVA
citation: http://purl.uniprot.org/citations/17218520
citation: http://purl.uniprot.org/citations/18552282
recommended name: SIP5B346F32DFAE924B
enzyme: http://purl.uniprot.org/enzyme/2.4.1.117
organism: http://purl.uniprot.org/taxonomy/412133
annotation: SIP18717D342313AA85
annotation: SIPC9B93B90A206501C
annotation: SIPD94913D413E91BD1
annotation: SIP3273AFA03A5A2592
annotation: SIP226862ABFBE4A4B4
annotation: PRO_0000431405
annotation: SIP8E2BC5AF5911FD92
annotation: SIPB5977DD7AA1D57DC
annotation: SIP23BB639830050D92
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/256
classified with: http://purl.uniprot.org/keywords/328
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/735
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0005789
classified with: GO_0004581
classified with: GO_0006487
sequence: A2DZE8-1
proteome: Unassembled WGS sequence

A2DZE8-citation-17218520
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC PRA-98 / G3
type: Strain

A2DZE8-citation-18552282
type: Citation Statement
scope: FUNCTION
scope: CATALYTIC ACTIVITY

KOG2977
type: Resource
database: eggNOG
comment: Eukaryota

cd04188
type: Resource
database: CDD
comment: DPG_synthase
signature sequence match: CDD cd04188 match 1

IPR035518
type: Resource
database: InterPro
comment: DPG_synthase

IPR001173
type: Resource
database: InterPro
comment: Glyco_trans_2-like

IPR029044
type: Resource
database: InterPro
comment: Nucleotide-diphossugar_trans

PTHR10859:SF91
type: Resource
database: PANTHER
comment: DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE
signature sequence match: PANTHER PTHR10859:SF91 match 1

PTHR10859
type: Resource
database: PANTHER
comment: GLYCOSYL TRANSFERASE
signature sequence match: PANTHER PTHR10859 match 1

PF00535
type: Resource
database: Pfam
comment: Glycos_transf_2
signature sequence match: Pfam PF00535 match 1

SSF53448
type: Resource
database: SUPFAM
comment: Nucleotide-diphospho-sugar transferases
signature sequence match: SUPFAM SSF53448 match 1

SIP5B346F32DFAE924B
type: Structured Name
full name: Dolichyl-phosphate beta-glucosyltransferase ALG5A
short name: DolP-glucosyltransferase
ec name: 2.4.1.117

ALG5A
type: Gene
orf name: TVAG_487200

SIP18717D342313AA85
type: Function Annotation
comment: Dolichyl-phosphate beta-glucosyltransferase involved in the glycosylation of glycoproteins through the synthesis of dolichyl beta-D-glucosyl phosphate which serves as a sugar donor for transfer of three glucose residues to the Man-9-GlcNAc-2-PP-dolichol precursor to N-glycans.

SIP226862ABFBE4A4B4
type: Similarity Annotation
comment: Belongs to the glycosyltransferase 2 family.

PRO_0000431405
type: Chain Annotation
comment: Dolichyl-phosphate beta-glucosyltransferase ALG5A
mass: 36764
range: 18351142639843374tt1tt323

18351142639843374tt1
type: Position
type: ExactPosition
position: 1
reference: A2DZE8-1

18351142639843374tt323
type: Position
type: ExactPosition
position: 323
reference: A2DZE8-1

SIP8E2BC5AF5911FD92
type: Topological Domain Annotation
comment: Cytoplasmic
range: 18351142639843374tt1tt5

18351142639843374tt5
type: Position
type: ExactPosition
position: 5
reference: A2DZE8-1

SIPB5977DD7AA1D57DC
type: Transmembrane Annotation
comment: Helical; Signal-anchor for type II membrane protein
range: 18351142639843374tt6tt26

18351142639843374tt6
type: Position
type: ExactPosition
position: 6
reference: A2DZE8-1

18351142639843374tt26
type: Position
type: ExactPosition
position: 26
reference: A2DZE8-1

SIP23BB639830050D92
type: Topological Domain Annotation
comment: Lumenal
range: 18351142639843374tt27tt323

18351142639843374tt27
type: Position
type: ExactPosition
position: 27
reference: A2DZE8-1

A2DZE8-1
type: Simple Sequence
modified: 2007-02-20
version: 1
mass: 36764
value: MKFWRFVQILFFLGVAAVGLVVAVMIANADDTTLFDRMQLPDGDPNKLNYYIQPAPNGNEKVPFPTIFDPASVYLSLVVPAYNEEKRLPKMLDETLNYLKSREEKDKSFTWEIVIVNDGSKDKTKEVVLNYAKEYPNIFLLNQPVNMGKGAAIQAGCLHVRGELVLMLDADGATKIDDFEVLEKEIKSLMKTTNQAIVIGSRAQNEKAKRTPLRKFLSIGMHTLIVLSGVHGIRDTQCGFKLFTRESCKMIFMNQHVQRWCCDPEILVIARRLGMKISELPVEWNEIDGSKMKISGMIKMATDLIKIAIFHRVGAWKIRDRRH

http://purl.uniprot.org/uniprot/A2DZE8#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/A2DZE8#attribution-C558313C6FD37C1A1B469EDAA26CA125
manual: true
evidence: ECO_0000250
source: P40350

http://purl.uniprot.org/uniprot/A2DZE8#attribution-D50D9C96477B23E7A4E6CDEB874232E4
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/A2DZE8#attribution-3D09A18AD67CCC5F754E019F6A09DAAD
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/18552282

http://purl.uniprot.org/uniprot/A2DZE8#attribution-6724B97897F62309D95188AF95AA3C93
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/17218520

http://purl.uniprot.org/uniprot/A2DZE8#attribution-A29E009F5A71F73BB0C6043C58A67286
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/18552282

http://purl.uniprot.org/uniprot/A2DZE8#attribution-BB1BA36B9FD3A4706BAB4E215759DCD7
manual: true
evidence: ECO_0000305

A2EK20
type: Protein
reviewed: true
created: 2015-01-07
modified: 2023-05-03
version: 66
mnemonic: ALG5B_TRIV3
old mnemonic: ALG5B_TRIVA
citation: http://purl.uniprot.org/citations/17218520
citation: http://purl.uniprot.org/citations/18552282
recommended name: SIP08ECF9F4C64E9DA5
enzyme: http://purl.uniprot.org/enzyme/2.4.1.117
organism: http://purl.uniprot.org/taxonomy/412133
annotation: SIPC6E4438D115A0771
annotation: SIP1469A631766461CC
annotation: SIP29615E0EF828B142
annotation: SIPE0E56A4D4AF107F2
annotation: SIP6111286E6B73D1DF
annotation: PRO_0000431406
annotation: SIP554B6040B403817C
annotation: SIP6198ED6FEC40C2C6
annotation: SIP062A725C886690AA
annotation: SIP5C1472C2B5762AB5
annotation: SIPAF3D3F78F4BCB607
annotation: SIP4B470D4BE0491C37
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/256
classified with: http://purl.uniprot.org/keywords/325
classified with: http://purl.uniprot.org/keywords/328
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/735
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0005789
classified with: GO_0004581
classified with: GO_0006487
sequence: A2EK20-1
proteome: Unassembled WGS sequence

A2EK20-citation-17218520
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC PRA-98 / G3
type: Strain

A2EK20-citation-18552282
type: Citation Statement
scope: FUNCTION
scope: CATALYTIC ACTIVITY

A2EK20
type: Resource
database: GlyCosmos
comment: 3 sites, No reported glycans

SIP08ECF9F4C64E9DA5
type: Structured Name
full name: Dolichyl-phosphate beta-glucosyltransferase ALG5B
short name: DolP-glucosyltransferase
ec name: 2.4.1.117

ALG5B
type: Gene
orf name: TVAG_174740

SIPC6E4438D115A0771
type: Function Annotation
comment: Dolichyl-phosphate beta-glucosyltransferase involved in the glycosylation of glycoproteins through the synthesis of dolichyl beta-D-glucosyl phosphate which serves as a sugar donor for transfer of three glucose residues to the Man-9-GlcNAc-2-PP-dolichol precursor to N-glycans.

SIP6111286E6B73D1DF
type: Similarity Annotation
comment: Belongs to the glycosyltransferase 2 family.

PRO_0000431406
type: Chain Annotation
comment: Dolichyl-phosphate beta-glucosyltransferase ALG5B
mass: 37915
range: 18351146681905198tt1tt333

18351146681905198tt1
type: Position
type: ExactPosition
position: 1
reference: A2EK20-1

18351146681905198tt333
type: Position
type: ExactPosition
position: 333
reference: A2EK20-1

SIP554B6040B403817C
type: Topological Domain Annotation
comment: Cytoplasmic
range: 18351146681905198tt1tt4

18351146681905198tt4
type: Position
type: ExactPosition
position: 4
reference: A2EK20-1

SIP6198ED6FEC40C2C6
type: Transmembrane Annotation
comment: Helical; Signal-anchor for type II membrane protein
range: 18351146681905198tt5tt25

18351146681905198tt5
type: Position
type: ExactPosition
position: 5
reference: A2EK20-1

18351146681905198tt25
type: Position
type: ExactPosition
position: 25
reference: A2EK20-1

SIP062A725C886690AA
type: Topological Domain Annotation
comment: Lumenal
range: 18351146681905198tt26tt333

18351146681905198tt26
type: Position
type: ExactPosition
position: 26
reference: A2EK20-1

SIP5C1472C2B5762AB5
type: Glycosylation Annotation
comment: N-linked (GlcNAc...) asparagine
range: 18351146681905198tt93tt93

18351146681905198tt93
type: Position
type: ExactPosition
position: 93
reference: A2EK20-1

SIPAF3D3F78F4BCB607
type: Glycosylation Annotation
comment: N-linked (GlcNAc...) asparagine
range: 18351146681905198tt108tt108

18351146681905198tt108
type: Position
type: ExactPosition
position: 108
reference: A2EK20-1

SIP4B470D4BE0491C37
type: Glycosylation Annotation
comment: N-linked (GlcNAc...) asparagine
range: 18351146681905198tt237tt237

18351146681905198tt237
type: Position
type: ExactPosition
position: 237
reference: A2EK20-1

A2EK20-1
type: Simple Sequence
modified: 2007-02-20
version: 1
mass: 37915
value: MIAEIADILGDICLLIFVFALIYAICSSVVSDETLYDRTLLASTDPRKLEYFIEPSHDEQPQLFPTIFDEPEVYATFVVPAYNEERRIPSMLNETLQFLDTRRDENPNFSYEIIVVDDGSKDKTAEVVLDFANSHPEIRLLKQPVNMGKGAAVAAGCSHARGQYILMVDADGATKIDEFNELEKKMLQLQQVNREAIVVGSRAHLEGQDKANRTPIRKFLGLSFHLLILLSGVRGINDTQCGFKLFSREASRYLFPNQHIERWCFDPELLVIGRKRKMQIAEVPVEWNEIEGSKMKVTSMIKMAIDLLRIALFHGMGIWTVKLKQAVYDQELI

http://purl.uniprot.org/uniprot/A2EK20#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/A2EK20#attribution-C558313C6FD37C1A1B469EDAA26CA125
manual: true
evidence: ECO_0000250
source: P40350

http://purl.uniprot.org/uniprot/A2EK20#attribution-D50D9C96477B23E7A4E6CDEB874232E4
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/A2EK20#attribution-97404DECF85EEE73FE599CEB62ACED50
manual: true
evidence: ECO_0000255
source: PRU00498

http://purl.uniprot.org/uniprot/A2EK20#attribution-3D09A18AD67CCC5F754E019F6A09DAAD
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/18552282

http://purl.uniprot.org/uniprot/A2EK20#attribution-6724B97897F62309D95188AF95AA3C93
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/17218520

http://purl.uniprot.org/uniprot/A2EK20#attribution-A29E009F5A71F73BB0C6043C58A67286
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/18552282

http://purl.uniprot.org/uniprot/A2EK20#attribution-BB1BA36B9FD3A4706BAB4E215759DCD7
manual: true
evidence: ECO_0000305

A2ELE6
type: Protein
reviewed: true
created: 2015-01-07
modified: 2023-05-03
version: 67
mnemonic: ALG5C_TRIV3
old mnemonic: ALG5C_TRIVA
citation: http://purl.uniprot.org/citations/17218520
citation: http://purl.uniprot.org/citations/18552282
recommended name: SIP760948F590CC6400
enzyme: http://purl.uniprot.org/enzyme/2.4.1.117
organism: http://purl.uniprot.org/taxonomy/412133
annotation: SIPB1826B25495979C4
annotation: SIP64431D8F66D7AE23
annotation: SIP6B95A7D93ADA5C36
annotation: SIP6F735E89AA33967C
annotation: SIP96131269B5BEED8D
annotation: PRO_0000431407
annotation: SIPDA1016F9F407EFB6
annotation: SIPC7B06BACD1BA8F09
annotation: SIP2BCAFD95EB72C881
annotation: SIP21DFB43E96C039E6
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/256
classified with: http://purl.uniprot.org/keywords/325
classified with: http://purl.uniprot.org/keywords/328
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/735
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0005789
classified with: GO_0004581
classified with: GO_0006487
sequence: A2ELE6-1
proteome: Unassembled WGS sequence

A2ELE6-citation-17218520
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC PRA-98 / G3
type: Strain

A2ELE6-citation-18552282
type: Citation Statement
scope: FUNCTION
scope: CATALYTIC ACTIVITY

A2ELE6
type: Resource
database: GlyCosmos
comment: 1 site, No reported glycans

SIP760948F590CC6400
type: Structured Name
full name: Dolichyl-phosphate beta-glucosyltransferase ALG5C
short name: DolP-glucosyltransferase
ec name: 2.4.1.117

ALG5C
type: Gene
orf name: TVAG_358380

SIPB1826B25495979C4
type: Function Annotation
comment: Dolichyl-phosphate beta-glucosyltransferase involved in the glycosylation of glycoproteins through the synthesis of dolichyl beta-D-glucosyl phosphate which serves as a sugar donor for transfer of three glucose residues to the Man-9-GlcNAc-2-PP-dolichol precursor to N-glycans.

SIP96131269B5BEED8D
type: Similarity Annotation
comment: Belongs to the glycosyltransferase 2 family.

PRO_0000431407
type: Chain Annotation
comment: Dolichyl-phosphate beta-glucosyltransferase ALG5C
mass: 38118
range: 18351146699929134tt1tt337

18351146699929134tt1
type: Position
type: ExactPosition
position: 1
reference: A2ELE6-1

18351146699929134tt337
type: Position
type: ExactPosition
position: 337
reference: A2ELE6-1

SIPDA1016F9F407EFB6
type: Topological Domain Annotation
comment: Cytoplasmic
range: 18351146699929134tt1tt6

18351146699929134tt6
type: Position
type: ExactPosition
position: 6
reference: A2ELE6-1

SIPC7B06BACD1BA8F09
type: Transmembrane Annotation
comment: Helical; Signal-anchor for type II membrane protein
range: 18351146699929134tt7tt27

18351146699929134tt7
type: Position
type: ExactPosition
position: 7
reference: A2ELE6-1

18351146699929134tt27
type: Position
type: ExactPosition
position: 27
reference: A2ELE6-1

SIP2BCAFD95EB72C881
type: Topological Domain Annotation
comment: Lumenal
range: 18351146699929134tt28tt337

18351146699929134tt28
type: Position
type: ExactPosition
position: 28
reference: A2ELE6-1

SIP21DFB43E96C039E6
type: Glycosylation Annotation
comment: N-linked (GlcNAc...) asparagine
range: 18351146699929134tt86tt86

18351146699929134tt86
type: Position
type: ExactPosition
position: 86
reference: A2ELE6-1

A2ELE6-1
type: Simple Sequence
modified: 2007-02-20
version: 1
mass: 38118
value: MNDLPPIANLISNILFVLLIITFLYALCSRFVSDKTLYDYTILPTNDPEKINYYIEPSPSPKEKIPFPTVFSPSEVYTTFVVPAYNESKRITPMLDETVAYLERRASENPEFTWEIIVVNDGSKDNTAEIVTNYAFKHPQIRLLNQPKNMGKGAAVQAGCLHSRGELILMVDADGATKIDEFEELEKKIKSLTTINKEAIVVGSRAHLEGAEKANRTPLRKFLGLGFHMLITIAGVHGIKDTQCGFKLFTREAARWLFPNQHVQRWCFDPELLVIAQSRQMEVAEVPVEWNEIGDSKMKISGMIKMAIDLVQIAIYFRAGLWTVKDKADTPISDFEV

http://purl.uniprot.org/uniprot/A2ELE6#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/A2ELE6#attribution-C558313C6FD37C1A1B469EDAA26CA125
manual: true
evidence: ECO_0000250
source: P40350

http://purl.uniprot.org/uniprot/A2ELE6#attribution-D50D9C96477B23E7A4E6CDEB874232E4
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/A2ELE6#attribution-97404DECF85EEE73FE599CEB62ACED50
manual: true
evidence: ECO_0000255
source: PRU00498

http://purl.uniprot.org/uniprot/A2ELE6#attribution-3D09A18AD67CCC5F754E019F6A09DAAD
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/18552282

http://purl.uniprot.org/uniprot/A2ELE6#attribution-6724B97897F62309D95188AF95AA3C93
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/17218520

http://purl.uniprot.org/uniprot/A2ELE6#attribution-A29E009F5A71F73BB0C6043C58A67286
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/18552282

http://purl.uniprot.org/uniprot/A2ELE6#attribution-BB1BA36B9FD3A4706BAB4E215759DCD7
manual: true
evidence: ECO_0000305

A2E3C6
type: Protein
reviewed: true
created: 2015-01-07
modified: 2023-05-03
version: 68
mnemonic: ALG5D_TRIV3
old mnemonic: ALG5D_TRIVA
citation: http://purl.uniprot.org/citations/17218520
citation: http://purl.uniprot.org/citations/18552282
recommended name: SIP1318A0B9DD2AAF54
enzyme: http://purl.uniprot.org/enzyme/2.4.1.117
organism: http://purl.uniprot.org/taxonomy/412133
annotation: SIP0897F1F8DD6F86F6
annotation: SIP8103E9FD68668F5E
annotation: SIP47EBF0FF435A3155
annotation: SIPAA0ACC1EF245D829
annotation: SIP3C2323799C32215A
annotation: PRO_0000431408
annotation: SIPA3965488A034F312
annotation: SIP53D90FFB00F466F1
annotation: SIP09D37A13330375C3
annotation: SIP79E211310602DD4F
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/256
classified with: http://purl.uniprot.org/keywords/325
classified with: http://purl.uniprot.org/keywords/328
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/735
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0005789
classified with: GO_0004581
classified with: GO_0006487
sequence: http://purl.uniprot.org/isoforms/A2E3C6-1
proteome: Unassembled WGS sequence

A2E3C6-citation-17218520
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC PRA-98 / G3
type: Strain

A2E3C6-citation-18552282
type: Citation Statement
scope: FUNCTION
scope: CATALYTIC ACTIVITY

A2E3C6
type: Resource
database: GlyCosmos
comment: 1 site, No reported glycans

SIP1318A0B9DD2AAF54
type: Structured Name
full name: Dolichyl-phosphate beta-glucosyltransferase ALG5D
short name: DolP-glucosyltransferase
ec name: 2.4.1.117

ALG5D
type: Gene
orf name: TVAG_221700

SIP0897F1F8DD6F86F6
type: Function Annotation
comment: Dolichyl-phosphate beta-glucosyltransferase involved in the glycosylation of glycoproteins through the synthesis of dolichyl beta-D-glucosyl phosphate which serves as a sugar donor for transfer of three glucose residues to the Man-9-GlcNAc-2-PP-dolichol precursor to N-glycans.

SIP3C2323799C32215A
type: Similarity Annotation
comment: Belongs to the glycosyltransferase 2 family.

PRO_0000431408
type: Chain Annotation
comment: Dolichyl-phosphate beta-glucosyltransferase ALG5D
mass: 37953
range: 18351146280367662tt1tt327

18351146280367662tt1
type: Position
type: ExactPosition
position: 1
reference: http://purl.uniprot.org/isoforms/A2E3C6-1

18351146280367662tt327
type: Position
type: ExactPosition
position: 327
reference: http://purl.uniprot.org/isoforms/A2E3C6-1

SIPA3965488A034F312
type: Topological Domain Annotation
comment: Cytoplasmic
range: 18351146280367662tt1tt6

18351146280367662tt6
type: Position
type: ExactPosition
position: 6
reference: http://purl.uniprot.org/isoforms/A2E3C6-1

SIP53D90FFB00F466F1
type: Transmembrane Annotation
comment: Helical; Signal-anchor for type II membrane protein
range: 18351146280367662tt7tt27

18351146280367662tt7
type: Position
type: ExactPosition
position: 7
reference: http://purl.uniprot.org/isoforms/A2E3C6-1

18351146280367662tt27
type: Position
type: ExactPosition
position: 27
reference: http://purl.uniprot.org/isoforms/A2E3C6-1

SIP09D37A13330375C3
type: Topological Domain Annotation
comment: Lumenal
range: 18351146280367662tt28tt327

18351146280367662tt28
type: Position
type: ExactPosition
position: 28
reference: http://purl.uniprot.org/isoforms/A2E3C6-1

SIP79E211310602DD4F
type: Glycosylation Annotation
comment: N-linked (GlcNAc...) asparagine
range: 18351146280367662tt109tt109

18351146280367662tt109
type: Position
type: ExactPosition
position: 109
reference: http://purl.uniprot.org/isoforms/A2E3C6-1

http://purl.uniprot.org/isoforms/A2E3C6-1
type: Simple Sequence
modified: 2007-02-20
version: 1
mass: 37953
value: MEKQLAELSVYILIIFLILGFIMAILMRFGDDTTLFDLTQLPKNNPKKLNYYVQPAKNPNENVPFKTIFDKPQVYVSFIVPAYNEEKRLPKMLEETIEYLEQRRYKDNNFTWEIVVVNDGSKDRTAHVVLEYAERYSNIFLLNQPHNMGKGAAIQAGCLHARGQLVLMVDADGATKISDFGLLENEIKKLMKNNKEAIVVGSRTLNEDKSKVHRTFIRKILGLGMHILIVISGVHGIKDTQCGFKLFTRDACKMLFMNQHVQRWCFDPELLVIARRRKMKVSEISVEWNEIEGSKMKISGMIKMAIDLLRIAVFYRLNIWTIRDRKF

http://purl.uniprot.org/uniprot/A2E3C6#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/A2E3C6#attribution-C558313C6FD37C1A1B469EDAA26CA125
manual: true
evidence: ECO_0000250
source: P40350

http://purl.uniprot.org/uniprot/A2E3C6#attribution-D50D9C96477B23E7A4E6CDEB874232E4
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/A2E3C6#attribution-97404DECF85EEE73FE599CEB62ACED50
manual: true
evidence: ECO_0000255
source: PRU00498

http://purl.uniprot.org/uniprot/A2E3C6#attribution-3D09A18AD67CCC5F754E019F6A09DAAD
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/18552282

http://purl.uniprot.org/uniprot/A2E3C6#attribution-6724B97897F62309D95188AF95AA3C93
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/17218520

http://purl.uniprot.org/uniprot/A2E3C6#attribution-A29E009F5A71F73BB0C6043C58A67286
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/18552282

http://purl.uniprot.org/uniprot/A2E3C6#attribution-BB1BA36B9FD3A4706BAB4E215759DCD7
manual: true
evidence: ECO_0000305

A2DSR8
type: Protein
reviewed: true
created: 2015-01-07
modified: 2023-05-03
version: 65
mnemonic: ALG5E_TRIV3
old mnemonic: ALG5E_TRIVA
citation: http://purl.uniprot.org/citations/17218520
citation: http://purl.uniprot.org/citations/18552282
recommended name: SIP6DA2221F39221D3F
enzyme: http://purl.uniprot.org/enzyme/2.4.1.117
organism: http://purl.uniprot.org/taxonomy/412133
annotation: SIPFD034F85CF5BCB06
annotation: SIPA1C39CA05EFBC073
annotation: SIP848B90BB9DB3E56C
annotation: SIPC6D1C2B60E4EA21B
annotation: SIP75848B32D915FF5F
annotation: PRO_0000431409
annotation: SIP668BB96A46E15854
annotation: SIP9634185DD69CD1F0
annotation: SIP5E00C0A6BD1B95DE
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/256
classified with: http://purl.uniprot.org/keywords/328
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/735
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0005789
classified with: GO_0004581
classified with: GO_0006487
sequence: A2DSR8-1
proteome: Unassembled WGS sequence

A2DSR8-citation-17218520
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC PRA-98 / G3
type: Strain

A2DSR8-citation-18552282
type: Citation Statement
scope: FUNCTION
scope: CATALYTIC ACTIVITY

SIP6DA2221F39221D3F
type: Structured Name
full name: Dolichyl-phosphate beta-glucosyltransferase ALG5E
short name: DolP-glucosyltransferase
ec name: 2.4.1.117

ALG5E
type: Gene
orf name: TVAG_347770

SIPFD034F85CF5BCB06
type: Function Annotation
comment: Dolichyl-phosphate beta-glucosyltransferase involved in the glycosylation of glycoproteins through the synthesis of dolichyl beta-D-glucosyl phosphate which serves as a sugar donor for transfer of three glucose residues to the Man-9-GlcNAc-2-PP-dolichol precursor to N-glycans.

SIP75848B32D915FF5F
type: Similarity Annotation
comment: Belongs to the glycosyltransferase 2 family.

PRO_0000431409
type: Chain Annotation
comment: Dolichyl-phosphate beta-glucosyltransferase ALG5E
mass: 36962
range: 18351142523254830tt1tt325

18351142523254830tt1
type: Position
type: ExactPosition
position: 1
reference: A2DSR8-1

18351142523254830tt325
type: Position
type: ExactPosition
position: 325
reference: A2DSR8-1

SIP668BB96A46E15854
type: Topological Domain Annotation
comment: Cytoplasmic
range: 18351142523254830tt1tt5

18351142523254830tt5
type: Position
type: ExactPosition
position: 5
reference: A2DSR8-1

SIP9634185DD69CD1F0
type: Transmembrane Annotation
comment: Helical; Signal-anchor for type II membrane protein
range: 18351142523254830tt6tt26

18351142523254830tt6
type: Position
type: ExactPosition
position: 6
reference: A2DSR8-1

18351142523254830tt26
type: Position
type: ExactPosition
position: 26
reference: A2DSR8-1

SIP5E00C0A6BD1B95DE
type: Topological Domain Annotation
comment: Lumenal
range: 18351142523254830tt27tt215

18351142523254830tt27
type: Position
type: ExactPosition
position: 27
reference: A2DSR8-1

18351142523254830tt215
type: Position
type: ExactPosition
position: 215
reference: A2DSR8-1

A2DSR8-1
type: Simple Sequence
modified: 2007-02-20
version: 1
mass: 36962
value: MNFWNFLEILLFIGIVAAGLIVAVMIKTAEDTTLFDRTQLPEDNPQKLNYYVQPPPNGDEKVPFPTVFEPAKVYTTFVVPAYNEEKRIPKMLDETVEYLKSREAKDKSFTWEIVVVNDGSKDKTKEVVLNYAKDYPNIFLLNQPVNMGKGAAIQAGCLHARGELVLMVDADGATKINEFEALETEIKKLMKNNNQAIVVGSRAQNEKANRTPIRKFLGLGMHVLIVLSGVRGIHDTQCGFKLFSREACKMLFMNQHVQRWCFDPELLVIGRRLGMKISEIPVEWNEIEGSKMKISGMIKMAIDLIDIAIFHRVGAWTIRDRRINK

http://purl.uniprot.org/uniprot/A2DSR8#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/A2DSR8#attribution-C558313C6FD37C1A1B469EDAA26CA125
manual: true
evidence: ECO_0000250
source: P40350

http://purl.uniprot.org/uniprot/A2DSR8#attribution-D50D9C96477B23E7A4E6CDEB874232E4
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/A2DSR8#attribution-3D09A18AD67CCC5F754E019F6A09DAAD
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/18552282

http://purl.uniprot.org/uniprot/A2DSR8#attribution-6724B97897F62309D95188AF95AA3C93
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/17218520

http://purl.uniprot.org/uniprot/A2DSR8#attribution-A29E009F5A71F73BB0C6043C58A67286
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/18552282

http://purl.uniprot.org/uniprot/A2DSR8#attribution-BB1BA36B9FD3A4706BAB4E215759DCD7
manual: true
evidence: ECO_0000305

Q9NFS4
type: Protein
reviewed: true
created: 2003-04-11
modified: 2023-06-28
version: 87
mnemonic: ANXE1_GIAIN
old mnemonic: ANXE1_GIALA
old mnemonic: ANXE2_GIALA
old mnemonic: ANXL_GIALA
replaces: Q24981
citation: SIP380F0F29D029A2B3
citation: http://purl.uniprot.org/citations/12006598
conflicting sequence: SIPB34C5117712D251E
recommended name: SIP8E9B0E343BC22D6D
alternative name: SIP16646E9349FF3A20
alternative name: SIPC52184F9FD75DCF9
organism: http://purl.uniprot.org/taxonomy/5741
annotation: SIP62920CCEB26648CD
annotation: SIPDF2E4E6668A9BFA6
annotation: SIP227F8BBDBFECEEDB
annotation: SIP28E228A0C84921ED
annotation: SIPCF6326CF3E7C565C
annotation: PRO_0000067521
annotation: SIP1A82FBA67B91D466
annotation: SIP83B7FED42194BC6E
annotation: SIP668F002F480EF804
annotation: SIPF7925FD93569C4CD
annotation: SIPBA67144AB460C147
annotation: SIPE8C1600AF5F4EB9B
annotation: SIPF099B5E6E737367D
annotation: SIP56E14A20ACB09645
annotation: SIP7FA18C8BD44A1E4C
annotation: SIPBFC950EA564929AE
annotation: SIPFFAA00507EF63672
annotation: SIP11CE9267156B0970
annotation: SIPA7015735F536954A
annotation: SIPE325CD7784A3FF5B
annotation: SIPCEEE831811FEA89A
annotation: SIP7125E029EB533480
annotation: SIP880A7DE310B20C19
annotation: SIP22FED86AF18C0DBD
annotation: SIPB44BB1F27DF8AB6D
annotation: SIP7DF5A32F74A1ACE9
annotation: SIP114661AA16A8D4A3
annotation: SIP823686CD41EECF10
annotation: SIP3FB99D886B02A262
annotation: SIPEE8890B2D287A91A
annotation: SIP5221D772F5E0428C
annotation: SIPDF5D19068FF57C97
annotation: SIPDE0BA2DE3B2EA8A0
annotation: SIPBF222F1742CDD9C8
annotation: SIP80EE509116DBBDB5
annotation: SIPFDD724DAB44E861C
annotation: SIP57635499C4D6D72C
annotation: SIPA25FFEC65184300A
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/41
classified with: http://purl.uniprot.org/keywords/111
classified with: http://purl.uniprot.org/keywords/970
classified with: http://purl.uniprot.org/keywords/282
classified with: http://purl.uniprot.org/keywords/677
classified with: GO_0031514
classified with: GO_0005509
classified with: GO_0005544
classified with: GO_0030030
sequence: Q9NFS4-1

SIP380F0F29D029A2B3
type: Submission Citation
author: Upcroft P.
author: Healey A.
author: Upcroft J.A.
author: Townson S.M.
date: 1995-08
submitted to: EMBL/GenBank/DDBJ

Q9NFS4-citation-SIP380F0F29D029A2B3
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

Q9NFS4-citation-12006598
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: SUBCELLULAR LOCATION

EMBL AAA74893.1
comment: Frameshift.

3CHJ
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 1.60
chain sequence mapping: PDB 3CHJ tt1tt337

PDB 3CHJ tt1tt337
chain: A=1-337

3CHK
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 1.65
chain sequence mapping: PDB 3CHK tt1tt337

PDB 3CHK tt1tt337
chain: A=1-337

3CHL
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 1.90
chain sequence mapping: PDB 3CHL tt1tt337

PDB 3CHL tt1tt337
chain: A=1-337

KOG0819
type: Resource
database: eggNOG
comment: Eukaryota

http://purl.uniprot.org/gene3d/1.10.220.10
type: Resource
database: Gene3D
comment: Annexin
signature sequence match: Gene3D 1.10.220.10 match 1
signature sequence match: Gene3D 1.10.220.10 match 2
signature sequence match: Gene3D 1.10.220.10 match 3
signature sequence match: Gene3D 1.10.220.10 match 4

IPR001464
type: Resource
database: InterPro
comment: Annexin

IPR018502
type: Resource
database: InterPro
comment: Annexin_repeat

IPR037104
type: Resource
database: InterPro
comment: Annexin_sf

PTHR10502
type: Resource
database: PANTHER
comment: ANNEXIN
signature sequence match: PANTHER PTHR10502 match 1

PTHR10502:SF102
type: Resource
database: PANTHER
comment: ANNEXIN A7
signature sequence match: PANTHER PTHR10502:SF102 match 1

PF00191
type: Resource
database: Pfam
comment: Annexin
signature sequence match: Pfam PF00191 match 1

PR00196
type: Resource
database: PRINTS
comment: ANNEXIN

SM00335
type: Resource
database: SMART
comment: ANX
signature sequence match: SMART SM00335 match 1
signature sequence match: SMART SM00335 match 2

SSF47874
type: Resource
database: SUPFAM
comment: Annexin
signature sequence match: SUPFAM SSF47874 match 1

PS51897
type: Resource
database: PROSITE
comment: ANNEXIN_2
signature sequence match: PROSITE PS51897 match 1
signature sequence match: PROSITE PS51897 match 2
signature sequence match: PROSITE PS51897 match 3
signature sequence match: PROSITE PS51897 match 4

SIP8E9B0E343BC22D6D
type: Structured Name
full name: Annexin E1

SIP16646E9349FF3A20
type: Structured Name
full name: Annexin 21

SIPC52184F9FD75DCF9
type: Structured Name
full name: Annexin XXI

ANXE1
type: Gene
alternative label: ANX21

SIP62920CCEB26648CD
type: Function Annotation
comment: May function as a calcium-regulated structural element linking phospholipid bilayer and underlying axoneme.

SIP227F8BBDBFECEEDB
type: Domain Annotation
comment: A pair of annexin repeats may form one binding site for calcium and phospholipid.

SIP28E228A0C84921ED
type: Similarity Annotation
comment: Belongs to the annexin family.

PRO_0000067521
type: Chain Annotation
comment: Annexin E1
mass: 38584
range: 22862481463653422tt1tt337

22862481463653422tt1
type: Position
type: ExactPosition
position: 1
reference: Q9NFS4-1

22862481463653422tt337
type: Position
type: ExactPosition
position: 337
reference: Q9NFS4-1

SIP1A82FBA67B91D466
type: Repeat Annotation
comment: Annexin 1
range: 22862481463653422tt10tt80

22862481463653422tt10
type: Position
type: ExactPosition
position: 10
reference: Q9NFS4-1

22862481463653422tt80
type: Position
type: ExactPosition
position: 80
reference: Q9NFS4-1

SIP83B7FED42194BC6E
type: Repeat Annotation
comment: Annexin 2
range: 22862481463653422tt81tt154

22862481463653422tt81
type: Position
type: ExactPosition
position: 81
reference: Q9NFS4-1

22862481463653422tt154
type: Position
type: ExactPosition
position: 154
reference: Q9NFS4-1

SIP668F002F480EF804
type: Repeat Annotation
comment: Annexin 3
range: 22862481463653422tt161tt238

22862481463653422tt161
type: Position
type: ExactPosition
position: 161
reference: Q9NFS4-1

22862481463653422tt238
type: Position
type: ExactPosition
position: 238
reference: Q9NFS4-1

SIPF7925FD93569C4CD
type: Repeat Annotation
comment: Annexin 4
range: 22862481463653422tt242tt312

22862481463653422tt242
type: Position
type: ExactPosition
position: 242
reference: Q9NFS4-1

22862481463653422tt312
type: Position
type: ExactPosition
position: 312
reference: Q9NFS4-1

22862481463653422tt12
type: Position
type: ExactPosition
position: 12
reference: Q9NFS4-1

22862481463653422tt24
type: Position
type: ExactPosition
position: 24
reference: Q9NFS4-1

22862481463653422tt26
type: Position
type: ExactPosition
position: 26
reference: Q9NFS4-1

22862481463653422tt30
type: Position
type: ExactPosition
position: 30
reference: Q9NFS4-1

22862481463653422tt31
type: Position
type: ExactPosition
position: 31
reference: Q9NFS4-1

22862481463653422tt38
type: Position
type: ExactPosition
position: 38
reference: Q9NFS4-1

22862481463653422tt41
type: Position
type: ExactPosition
position: 41
reference: Q9NFS4-1

22862481463653422tt55
type: Position
type: ExactPosition
position: 55
reference: Q9NFS4-1

22862481463653422tt59
type: Position
type: ExactPosition
position: 59
reference: Q9NFS4-1

22862481463653422tt64
type: Position
type: ExactPosition
position: 64
reference: Q9NFS4-1

22862481463653422tt69
type: Position
type: ExactPosition
position: 69
reference: Q9NFS4-1

22862481463653422tt78
type: Position
type: ExactPosition
position: 78
reference: Q9NFS4-1

22862481463653422tt82
type: Position
type: ExactPosition
position: 82
reference: Q9NFS4-1

22862481463653422tt94
type: Position
type: ExactPosition
position: 94
reference: Q9NFS4-1

22862481463653422tt95
type: Position
type: ExactPosition
position: 95
reference: Q9NFS4-1

22862481463653422tt98
type: Position
type: ExactPosition
position: 98
reference: Q9NFS4-1

22862481463653422tt101
type: Position
type: ExactPosition
position: 101
reference: Q9NFS4-1

22862481463653422tt108
type: Position
type: ExactPosition
position: 108
reference: Q9NFS4-1

22862481463653422tt113
type: Position
type: ExactPosition
position: 113
reference: Q9NFS4-1

22862481463653422tt127
type: Position
type: ExactPosition
position: 127
reference: Q9NFS4-1

22862481463653422tt131
type: Position
type: ExactPosition
position: 131
reference: Q9NFS4-1

22862481463653422tt139
type: Position
type: ExactPosition
position: 139
reference: Q9NFS4-1

22862481463653422tt141
type: Position
type: ExactPosition
position: 141
reference: Q9NFS4-1

22862481463653422tt143
type: Position
type: ExactPosition
position: 143
reference: Q9NFS4-1

22862481463653422tt144
type: Position
type: ExactPosition
position: 144
reference: Q9NFS4-1

22862481463653422tt162
type: Position
type: ExactPosition
position: 162
reference: Q9NFS4-1

22862481463653422tt177
type: Position
type: ExactPosition
position: 177
reference: Q9NFS4-1

22862481463653422tt178
type: Position
type: ExactPosition
position: 178
reference: Q9NFS4-1

22862481463653422tt180
type: Position
type: ExactPosition
position: 180
reference: Q9NFS4-1

22862481463653422tt183
type: Position
type: ExactPosition
position: 183
reference: Q9NFS4-1

22862481463653422tt185
type: Position
type: ExactPosition
position: 185
reference: Q9NFS4-1

22862481463653422tt186
type: Position
type: ExactPosition
position: 186
reference: Q9NFS4-1

22862481463653422tt195
type: Position
type: ExactPosition
position: 195
reference: Q9NFS4-1

22862481463653422tt198
type: Position
type: ExactPosition
position: 198
reference: Q9NFS4-1

22862481463653422tt211
type: Position
type: ExactPosition
position: 211
reference: Q9NFS4-1

22862481463653422tt212
type: Position
type: ExactPosition
position: 212
reference: Q9NFS4-1

22862481463653422tt214
type: Position
type: ExactPosition
position: 214
reference: Q9NFS4-1

22862481463653422tt217
type: Position
type: ExactPosition
position: 217
reference: Q9NFS4-1

22862481463653422tt224
type: Position
type: ExactPosition
position: 224
reference: Q9NFS4-1

22862481463653422tt227
type: Position
type: ExactPosition
position: 227
reference: Q9NFS4-1

22862481463653422tt241
type: Position
type: ExactPosition
position: 241
reference: Q9NFS4-1

22862481463653422tt243
type: Position
type: ExactPosition
position: 243
reference: Q9NFS4-1

22862481463653422tt254
type: Position
type: ExactPosition
position: 254
reference: Q9NFS4-1

22862481463653422tt257
type: Position
type: ExactPosition
position: 257
reference: Q9NFS4-1

22862481463653422tt259
type: Position
type: ExactPosition
position: 259
reference: Q9NFS4-1

22862481463653422tt262
type: Position
type: ExactPosition
position: 262
reference: Q9NFS4-1

22862481463653422tt272
type: Position
type: ExactPosition
position: 272
reference: Q9NFS4-1

22862481463653422tt273
type: Position
type: ExactPosition
position: 273
reference: Q9NFS4-1

22862481463653422tt275
type: Position
type: ExactPosition
position: 275
reference: Q9NFS4-1

22862481463653422tt279
type: Position
type: ExactPosition
position: 279
reference: Q9NFS4-1

22862481463653422tt287
type: Position
type: ExactPosition
position: 287
reference: Q9NFS4-1

22862481463653422tt291
type: Position
type: ExactPosition
position: 291
reference: Q9NFS4-1

22862481463653422tt298
type: Position
type: ExactPosition
position: 298
reference: Q9NFS4-1

22862481463653422tt301
type: Position
type: ExactPosition
position: 301
reference: Q9NFS4-1

22862481463653422tt310
type: Position
type: ExactPosition
position: 310
reference: Q9NFS4-1

Q9NFS4-1
type: Simple Sequence
modified: 2000-10-01
version: 1
mass: 38584
value: MANKNYQMSTGVTAVVQKVVEACQDESKRLDLIEIARSYPPNQLRNMQRTFQAITGTFLDAFLKKHLSKDFESLVLMLYKPRAQLLCELIRGATKGAGTDEKCLVDVLLTIETHEVREIRQLYYQLYNDSLGDVVRKDCGDKYMWAKLINAVATGDRIPRDTHELEEDLVLVRKAIETKGVKKDEVSTWIRIFATYTRADFRQLHKMYSAKYNGDSLRAGVEDEFQGLDEYAFKLAHDFLYDPCCAAAFSMNVAFAGSGSDSNRLNRITAMHFRECKGCKYYYKKVYGQAFDERCATELKGVYGDAIKLLWEPVTVPLLSMDDYQGSEQHRPMTLEL

http://purl.uniprot.org/uniprot/Q9NFS4#attribution-4604434B404AEEB73BB04DA731D8FF52
manual: true
evidence: ECO_0000255
source: PRU01245

http://purl.uniprot.org/uniprot/Q9NFS4#attribution-E6A680030AA2D33910C8367952A1E959
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/12006598

http://purl.uniprot.org/uniprot/Q9NFS4#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

P26991
type: Protein
reviewed: true
created: 1992-08-01
modified: 2023-09-13
version: 98
mnemonic: ARF_GIAIN
old mnemonic: ARF_GIALA
citation: http://purl.uniprot.org/citations/1577802
recommended name: SIP73C3315728061395
organism: http://purl.uniprot.org/taxonomy/5741
annotation: SIPE216ECE93E93C6A4
annotation: SIP8ED94858B731C6F8
annotation: SIP05D91A3297AF2578
annotation: SIP9F344E2941FA7113
annotation: PRO_0000207424
annotation: SIP1BC9AB1E48E33180
annotation: SIP305F1BC5D4A6E449
annotation: SIPD5F0042E2D7B7356
annotation: SIP274E486E6337C940
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/931
classified with: http://purl.uniprot.org/keywords/333
classified with: http://purl.uniprot.org/keywords/342
classified with: http://purl.uniprot.org/keywords/519
classified with: http://purl.uniprot.org/keywords/653
classified with: GO_0005794
classified with: GO_0005525
classified with: GO_0003924
classified with: GO_0015031
classified with: GO_0016192
sequence: MGQGASKIFGKLFSKKEVRILMVGLDAAGKTTILYKLMLGEVVTTVPTIGFNVETVEYKNINFTVWDVGGQDSIRPLWRHYYQNTDALIYVIDSADLEPKRIEDAKNELHTLLGEDELRDAALLVFANKQDLPKAMSTTDLTERLGLQELKKRDWYIQPTCARSGDGLYQGLDWLSDYIFDKKNKKKGKKR

P26991-citation-1577802
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

KOG0070
type: Resource
database: eggNOG
comment: Eukaryota

cd04150
type: Resource
database: CDD
comment: Arf1_5_like
signature sequence match: CDD cd04150 match 1

http://purl.uniprot.org/gene3d/3.40.50.300
type: Resource
database: Gene3D
comment: P-loop containing nucleotide triphosphate hydrolases
signature sequence match: Gene3D 3.40.50.300 match 1
signature sequence match: Gene3D 3.40.50.300 match 2
signature sequence match: Gene3D 3.40.50.300 match 3
signature sequence match: Gene3D 3.40.50.300 match 4
signature sequence match: Gene3D 3.40.50.300 match 5
signature sequence match: Gene3D 3.40.50.300 match 6

IPR045872
type: Resource
database: InterPro
comment: Arf1-5-like

IPR027417
type: Resource
database: InterPro
comment: P-loop_NTPase

IPR005225
type: Resource
database: InterPro
comment: Small_GTP-bd_dom

IPR024156
type: Resource
database: InterPro
comment: Small_GTPase_ARF

IPR006689
type: Resource
database: InterPro
comment: Small_GTPase_ARF/SAR

TIGR00231
type: Resource
database: NCBIfam
comment: small_GTP
signature sequence match: NCBIfam TIGR00231 match 1

PTHR11711
type: Resource
database: PANTHER
comment: ADP RIBOSYLATION FACTOR-RELATED
signature sequence match: PANTHER PTHR11711 match 1

PTHR11711:SF30
type: Resource
database: PANTHER
comment: ADP-RIBOSYLATION FACTOR 1-RELATED
signature sequence match: PANTHER PTHR11711:SF30 match 1

PF00025
type: Resource
database: Pfam
comment: Arf
signature sequence match: Pfam PF00025 match 1

PR00328
type: Resource
database: PRINTS
comment: SAR1GTPBP

SM00177
type: Resource
database: SMART
comment: ARF
signature sequence match: SMART SM00177 match 1

SM00178
type: Resource
database: SMART
comment: SAR
signature sequence match: SMART SM00178 match 1

SSF52540
type: Resource
database: SUPFAM
comment: P-loop containing nucleoside triphosphate hydrolases
signature sequence match: SUPFAM SSF52540 match 1
signature sequence match: SUPFAM SSF52540 match 2
signature sequence match: SUPFAM SSF52540 match 3
signature sequence match: SUPFAM SSF52540 match 4
signature sequence match: SUPFAM SSF52540 match 5
signature sequence match: SUPFAM SSF52540 match 6

PS51417
type: Resource
database: PROSITE
comment: ARF
signature sequence match: PROSITE PS51417 match 1

SIP73C3315728061395
type: Structured Name
full name: ADP-ribosylation factor

SIPE216ECE93E93C6A4
type: Function Annotation
comment: GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

SIP05D91A3297AF2578
type: Similarity Annotation
comment: Belongs to the small GTPase superfamily. Arf family.

SIP9F344E2941FA7113
type: Initiator Methionine Annotation
comment: Removed
range: 22573206606524718tt1tt1

22573206606524718tt1
type: Position
type: ExactPosition
position: 1
reference: MGQGASKIFGKLFSKKEVRILMVGLDAAGKTTILYKLMLGEVVTTVPTIGFNVETVEYKNINFTVWDVGGQDSIRPLWRHYYQNTDALIYVIDSADLEPKRIEDAKNELHTLLGEDELRDAALLVFANKQDLPKAMSTTDLTERLGLQELKKRDWYIQPTCARSGDGLYQGLDWLSDYIFDKKNKKKGKKR

PRO_0000207424
type: Chain Annotation
comment: ADP-ribosylation factor
mass: 21634
range: 22573206606524718tt2tt191

22573206606524718tt2
type: Position
type: ExactPosition
position: 2
reference: MGQGASKIFGKLFSKKEVRILMVGLDAAGKTTILYKLMLGEVVTTVPTIGFNVETVEYKNINFTVWDVGGQDSIRPLWRHYYQNTDALIYVIDSADLEPKRIEDAKNELHTLLGEDELRDAALLVFANKQDLPKAMSTTDLTERLGLQELKKRDWYIQPTCARSGDGLYQGLDWLSDYIFDKKNKKKGKKR

22573206606524718tt191
type: Position
type: ExactPosition
position: 191
reference: MGQGASKIFGKLFSKKEVRILMVGLDAAGKTTILYKLMLGEVVTTVPTIGFNVETVEYKNINFTVWDVGGQDSIRPLWRHYYQNTDALIYVIDSADLEPKRIEDAKNELHTLLGEDELRDAALLVFANKQDLPKAMSTTDLTERLGLQELKKRDWYIQPTCARSGDGLYQGLDWLSDYIFDKKNKKKGKKR

22573206606524718tt24
type: Position
type: ExactPosition
position: 24
reference: MGQGASKIFGKLFSKKEVRILMVGLDAAGKTTILYKLMLGEVVTTVPTIGFNVETVEYKNINFTVWDVGGQDSIRPLWRHYYQNTDALIYVIDSADLEPKRIEDAKNELHTLLGEDELRDAALLVFANKQDLPKAMSTTDLTERLGLQELKKRDWYIQPTCARSGDGLYQGLDWLSDYIFDKKNKKKGKKR

22573206606524718tt31
type: Position
type: ExactPosition
position: 31
reference: MGQGASKIFGKLFSKKEVRILMVGLDAAGKTTILYKLMLGEVVTTVPTIGFNVETVEYKNINFTVWDVGGQDSIRPLWRHYYQNTDALIYVIDSADLEPKRIEDAKNELHTLLGEDELRDAALLVFANKQDLPKAMSTTDLTERLGLQELKKRDWYIQPTCARSGDGLYQGLDWLSDYIFDKKNKKKGKKR

22573206606524718tt67
type: Position
type: ExactPosition
position: 67
reference: MGQGASKIFGKLFSKKEVRILMVGLDAAGKTTILYKLMLGEVVTTVPTIGFNVETVEYKNINFTVWDVGGQDSIRPLWRHYYQNTDALIYVIDSADLEPKRIEDAKNELHTLLGEDELRDAALLVFANKQDLPKAMSTTDLTERLGLQELKKRDWYIQPTCARSGDGLYQGLDWLSDYIFDKKNKKKGKKR

22573206606524718tt71
type: Position
type: ExactPosition
position: 71
reference: MGQGASKIFGKLFSKKEVRILMVGLDAAGKTTILYKLMLGEVVTTVPTIGFNVETVEYKNINFTVWDVGGQDSIRPLWRHYYQNTDALIYVIDSADLEPKRIEDAKNELHTLLGEDELRDAALLVFANKQDLPKAMSTTDLTERLGLQELKKRDWYIQPTCARSGDGLYQGLDWLSDYIFDKKNKKKGKKR

22573206606524718tt128
type: Position
type: ExactPosition
position: 128
reference: MGQGASKIFGKLFSKKEVRILMVGLDAAGKTTILYKLMLGEVVTTVPTIGFNVETVEYKNINFTVWDVGGQDSIRPLWRHYYQNTDALIYVIDSADLEPKRIEDAKNELHTLLGEDELRDAALLVFANKQDLPKAMSTTDLTERLGLQELKKRDWYIQPTCARSGDGLYQGLDWLSDYIFDKKNKKKGKKR

22573206606524718tt131
type: Position
type: ExactPosition
position: 131
reference: MGQGASKIFGKLFSKKEVRILMVGLDAAGKTTILYKLMLGEVVTTVPTIGFNVETVEYKNINFTVWDVGGQDSIRPLWRHYYQNTDALIYVIDSADLEPKRIEDAKNELHTLLGEDELRDAALLVFANKQDLPKAMSTTDLTERLGLQELKKRDWYIQPTCARSGDGLYQGLDWLSDYIFDKKNKKKGKKR

SIP274E486E6337C940
type: Lipidation Annotation
comment: N-myristoyl glycine
range: 22573206606524718tt2tt2

MGQGASKIFGKLFSKKEVRILMVGLDAAGKTTILYKLMLGEVVTTVPTIGFNVETVEYKNINFTVWDVGGQDSIRPLWRHYYQNTDALIYVIDSADLEPKRIEDAKNELHTLLGEDELRDAALLVFANKQDLPKAMSTTDLTERLGLQELKKRDWYIQPTCARSGDGLYQGLDWLSDYIFDKKNKKKGKKR
type: Simple Sequence
modified: 2007-01-23
version: 3
mass: 21765

http://purl.uniprot.org/uniprot/P26991#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/P26991#attribution-DC036A124EC8E88DF072B29F6D9BB9FE
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/P26991#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

A8B3G9
type: Protein
reviewed: true
created: 2009-11-03
modified: 2023-09-13
version: 80
mnemonic: ASNA_GIAIC
old mnemonic: ASNA_GIAIN
old mnemonic: ASNA_GIALA
citation: http://purl.uniprot.org/citations/17901334
recommended name: SIPB4966B1FED2D3535
alternative name: SIPCBBE28D26C15E422
alternative name: SIPD84B9906671FBF1B
enzyme: http://purl.uniprot.org/enzyme/3.6.-.-
organism: http://purl.uniprot.org/taxonomy/184922
annotation: SIPF83FFDA391236D9B
annotation: SIP06A69FE77F872EE4
annotation: SIP5980FF802BE9365D
annotation: SIPF0232B91F1C83EBB
annotation: PRO_0000388239
annotation: SIPE357FCD31F4FA52D
annotation: SIP388265A6E9401AA5
annotation: SIP435DB929155B168B
annotation: SIPEF93C9071E4BE19E
annotation: SIP48CA72AC8081B9CA
annotation: SIP49A2D963DDE3DC2A
annotation: SIP185B4338B14FFA6D
annotation: SIP76BD4E414F3F60F6
annotation: SIPD763DFFBABCE4D8F
annotation: SIP0A81ABB438AB652A
annotation: SIP433FCB2628AE7364
annotation: SIPF12E4F2C6D48D298
annotation: SIPB286470F74878460
annotation: SIP6DCC2458F187765D
annotation: SIPE9017A50993432E2
annotation: SIPD1EF14B37A5759C8
annotation: SIP71D8C04378CE279F
annotation: SIP715BFB0104070C70
annotation: SIP985B7DB8DDF9AAD0
annotation: SIPC1235EA60420C806
annotation: SIP2C6E71FF7A8AA1CE
annotation: SIP7EA10EB28381C852
annotation: SIP10CA6868A4A39EC0
annotation: SIPF54D274A3FE623D4
annotation: SIPB8E3E61760DFDFBC
annotation: SIPE5D4C0FB8B302B61
annotation: SIPF83D6243F83AA573
annotation: SIP837D79109726574A
annotation: SIP0E2BFB15BC9303FD
annotation: SIP6BFEAA042CF1ADBE
annotation: SIPDEFC76977F9F1E31
annotation: SIP5DB6A10E807913E1
annotation: SIP1ED896F2A17037F9
annotation: SIPD40043393822924E
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/256
classified with: http://purl.uniprot.org/keywords/378
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/813
classified with: http://purl.uniprot.org/keywords/862
classified with: GO_0005783
classified with: GO_0005524
classified with: GO_0016887
classified with: GO_0046872
classified with: GO_0045048
sequence: A8B3G9-1

A8B3G9-citation-17901334
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 50803 / WB clone C6
type: Strain

7SPY
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.23
chain sequence mapping: PDB 7SPY tt1tt354

PDB 7SPY tt1tt354
chain: A=1-354

7SPZ
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 3.00
chain sequence mapping: PDB 7SPZ tt1tt347

PDB 7SPZ tt1tt347
chain: A/B=1-347

7SQ0
type: Structure Resource
database: PDB
method: Electron Microscopy
resolution: 3.70
chain sequence mapping: PDB 7SQ0 tt1tt354

PDB 7SQ0 tt1tt354
chain: A/B=1-354

cd02035
type: Resource
database: CDD
comment: ArsA
signature sequence match: CDD cd02035 match 1

MF_03112
type: Resource
database: HAMAP
comment: Asna1_Get3
signature sequence match: HAMAP MF 03112 match 1

IPR025723
type: Resource
database: InterPro
comment: Anion-transp_ATPase-like_dom

IPR016300
type: Resource
database: InterPro
comment: ATPase_ArsA/GET3

IPR027542
type: Resource
database: InterPro
comment: ATPase_ArsA/GET3_euk

TIGR00345
type: Resource
database: NCBIfam
comment: GET3_arsA_TRC40
signature sequence match: NCBIfam TIGR00345 match 1

PTHR10803
type: Resource
database: PANTHER
comment: ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE
signature sequence match: PANTHER PTHR10803 match 1

PTHR10803:SF3
type: Resource
database: PANTHER
comment: ATPASE GET3
signature sequence match: PANTHER PTHR10803:SF3 match 1

PF02374
type: Resource
database: Pfam
comment: ArsA_ATPase
signature sequence match: Pfam PF02374 match 1

SIPB4966B1FED2D3535
type: Structured Name
full name: ATPase ASNA1 homolog
ec name: 3.6.-.-

SIPCBBE28D26C15E422
type: Structured Name
full name: Arsenical pump-driving ATPase homolog

SIPD84B9906671FBF1B
type: Structured Name
full name: Arsenite-stimulated ATPase

http://purl.uniprot.org/uniprot/A8B3G9#gene-MD5CFEE7C0C2D22AD8508065A6E7708FAD5
type: Gene
orf name: GL50803_7953

SIPF83FFDA391236D9B
type: Function Annotation
comment: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.

SIP06A69FE77F872EE4
type: Subunit Annotation
comment: Homodimer.

SIPF0232B91F1C83EBB
type: Similarity Annotation
comment: Belongs to the arsA ATPase family.

PRO_0000388239
type: Chain Annotation
comment: ATPase ASNA1 homolog
mass: 39506
range: 18357730465495342tt1tt354

18357730465495342tt1
type: Position
type: ExactPosition
position: 1
reference: A8B3G9-1

18357730465495342tt354
type: Position
type: ExactPosition
position: 354
reference: A8B3G9-1

18357730465495342tt53
type: Position
type: ExactPosition
position: 53
reference: A8B3G9-1

18357730465495342tt22
type: Position
type: ExactPosition
position: 22
reference: A8B3G9-1

18357730465495342tt29
type: Position
type: ExactPosition
position: 29
reference: A8B3G9-1

18357730465495342tt249
type: Position
type: ExactPosition
position: 249
reference: A8B3G9-1

18357730465495342tt276
type: Position
type: ExactPosition
position: 276
reference: A8B3G9-1

18357730465495342tt287
type: Position
type: ExactPosition
position: 287
reference: A8B3G9-1

18357730465495342tt290
type: Position
type: ExactPosition
position: 290
reference: A8B3G9-1

18357730465495342tt3
type: Position
type: ExactPosition
position: 3
reference: A8B3G9-1

18357730465495342tt5
type: Position
type: ExactPosition
position: 5
reference: A8B3G9-1

18357730465495342tt6
type: Position
type: ExactPosition
position: 6
reference: A8B3G9-1

18357730465495342tt10
type: Position
type: ExactPosition
position: 10
reference: A8B3G9-1

18357730465495342tt16
type: Position
type: ExactPosition
position: 16
reference: A8B3G9-1

18357730465495342tt20
type: Position
type: ExactPosition
position: 20
reference: A8B3G9-1

18357730465495342tt26
type: Position
type: ExactPosition
position: 26
reference: A8B3G9-1

18357730465495342tt27
type: Position
type: ExactPosition
position: 27
reference: A8B3G9-1

18357730465495342tt41
type: Position
type: ExactPosition
position: 41
reference: A8B3G9-1

18357730465495342tt43
type: Position
type: ExactPosition
position: 43
reference: A8B3G9-1

18357730465495342tt45
type: Position
type: ExactPosition
position: 45
reference: A8B3G9-1

18357730465495342tt47
type: Position
type: ExactPosition
position: 47
reference: A8B3G9-1

18357730465495342tt51
type: Position
type: ExactPosition
position: 51
reference: A8B3G9-1

18357730465495342tt58
type: Position
type: ExactPosition
position: 58
reference: A8B3G9-1

18357730465495342tt62
type: Position
type: ExactPosition
position: 62
reference: A8B3G9-1

18357730465495342tt71
type: Position
type: ExactPosition
position: 71
reference: A8B3G9-1

18357730465495342tt73
type: Position
type: ExactPosition
position: 73
reference: A8B3G9-1

18357730465495342tt76
type: Position
type: ExactPosition
position: 76
reference: A8B3G9-1

18357730465495342tt83
type: Position
type: ExactPosition
position: 83
reference: A8B3G9-1

18357730465495342tt117
type: Position
type: ExactPosition
position: 117
reference: A8B3G9-1

18357730465495342tt129
type: Position
type: ExactPosition
position: 129
reference: A8B3G9-1

18357730465495342tt133
type: Position
type: ExactPosition
position: 133
reference: A8B3G9-1

18357730465495342tt135
type: Position
type: ExactPosition
position: 135
reference: A8B3G9-1

18357730465495342tt140
type: Position
type: ExactPosition
position: 140
reference: A8B3G9-1

18357730465495342tt156
type: Position
type: ExactPosition
position: 156
reference: A8B3G9-1

18357730465495342tt159
type: Position
type: ExactPosition
position: 159
reference: A8B3G9-1

18357730465495342tt164
type: Position
type: ExactPosition
position: 164
reference: A8B3G9-1

18357730465495342tt167
type: Position
type: ExactPosition
position: 167
reference: A8B3G9-1

18357730465495342tt169
type: Position
type: ExactPosition
position: 169
reference: A8B3G9-1

18357730465495342tt173
type: Position
type: ExactPosition
position: 173
reference: A8B3G9-1

18357730465495342tt176
type: Position
type: ExactPosition
position: 176
reference: A8B3G9-1

18357730465495342tt177
type: Position
type: ExactPosition
position: 177
reference: A8B3G9-1

18357730465495342tt193
type: Position
type: ExactPosition
position: 193
reference: A8B3G9-1

18357730465495342tt195
type: Position
type: ExactPosition
position: 195
reference: A8B3G9-1

18357730465495342tt197
type: Position
type: ExactPosition
position: 197
reference: A8B3G9-1

18357730465495342tt198
type: Position
type: ExactPosition
position: 198
reference: A8B3G9-1

18357730465495342tt206
type: Position
type: ExactPosition
position: 206
reference: A8B3G9-1

18357730465495342tt210
type: Position
type: ExactPosition
position: 210
reference: A8B3G9-1

18357730465495342tt233
type: Position
type: ExactPosition
position: 233
reference: A8B3G9-1

18357730465495342tt237
type: Position
type: ExactPosition
position: 237
reference: A8B3G9-1

18357730465495342tt239
type: Position
type: ExactPosition
position: 239
reference: A8B3G9-1

18357730465495342tt240
type: Position
type: ExactPosition
position: 240
reference: A8B3G9-1

18357730465495342tt246
type: Position
type: ExactPosition
position: 246
reference: A8B3G9-1

18357730465495342tt250
type: Position
type: ExactPosition
position: 250
reference: A8B3G9-1

18357730465495342tt265
type: Position
type: ExactPosition
position: 265
reference: A8B3G9-1

18357730465495342tt272
type: Position
type: ExactPosition
position: 272
reference: A8B3G9-1

18357730465495342tt278
type: Position
type: ExactPosition
position: 278
reference: A8B3G9-1

18357730465495342tt288
type: Position
type: ExactPosition
position: 288
reference: A8B3G9-1

18357730465495342tt307
type: Position
type: ExactPosition
position: 307
reference: A8B3G9-1

18357730465495342tt308
type: Position
type: ExactPosition
position: 308
reference: A8B3G9-1

18357730465495342tt310
type: Position
type: ExactPosition
position: 310
reference: A8B3G9-1

18357730465495342tt311
type: Position
type: ExactPosition
position: 311
reference: A8B3G9-1

18357730465495342tt317
type: Position
type: ExactPosition
position: 317
reference: A8B3G9-1

18357730465495342tt326
type: Position
type: ExactPosition
position: 326
reference: A8B3G9-1

18357730465495342tt337
type: Position
type: ExactPosition
position: 337
reference: A8B3G9-1

SIP4C9F4E76B2A96157
subclass of: CHEBI_29105
comment: ligand shared between dimeric partners

A8B3G9-1
type: Simple Sequence
modified: 2007-11-13
version: 1
mass: 39506
value: MLPSLHDILDQHTYKWIFFGGKGGVGKTTTSSSFSVLMAETRPNEKFLLLSTDPAHNISDAFDQKFGKAPTQVSGIPNLYAMEVDASNEMKSAVEAVQKETGSAADNDAESKSEGDMFGGLNDLITCASSFIKDGTFPGMDEMWSFINLIKLIDTNEYSTVIFDTAPTGHTLRFLELPETVNKVLEIFTRLKDNMGGMLSMVMQTMGLSQNDIFGLIDKTYPKIDVVKRISAEFRDPSLCTFVGVCIPEFLSLYETERLVQRLAVLDMDCHAIVINFVLDANAATPCSMCRSRARMQNKYIDQINELYDDFNIVLSPLRHDEVRGIANLRDYAETLIKPYRFCWSANPDPSSAK

http://purl.uniprot.org/uniprot/A8B3G9#attribution-112ECABA3446E816E3B0A6A072E546C4
manual: true
evidence: ECO_0000255
source: MF_03112

A8BM50
type: Protein
reviewed: true
created: 2010-11-30
modified: 2023-06-28
version: 66
mnemonic: ATAT_GIAIC
old mnemonic: ATAT_GIAIN
old mnemonic: MC17_GIAIN
citation: http://purl.uniprot.org/citations/17901334
recommended name: SIP81A0153FE7D546C9
alternative name: SIP8A567449DBA275AD
enzyme: http://purl.uniprot.org/enzyme/2.3.1.108
organism: http://purl.uniprot.org/taxonomy/184922
annotation: SIP1C8726D7768B9A7C
annotation: SIP4BCF8DECD4DD2D28
annotation: SIPF9DE9B4FF7EA495D
annotation: PRO_0000402089
annotation: SIPD81663EE12BA3A81
annotation: SIPFA268DB4CB552EB2
annotation: SIP7F81DC38D2875364
annotation: SIPDA8BFD239F6839BF
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/12
classified with: GO_0005874
classified with: GO_0019799
classified with: GO_0071929
classified with: GO_0070507
sequence: A8BM50-1

A8BM50-citation-17901334
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 50803 / WB clone C6
type: Strain

cd04301
type: Resource
database: CDD
comment: NAT_SF
signature sequence match: CDD cd04301 match 1

MF_03130
type: Resource
database: HAMAP
comment: mec17
signature sequence match: HAMAP MF 03130 match 1

IPR016181
type: Resource
database: InterPro
comment: Acyl_CoA_acyltransferase

IPR038746
type: Resource
database: InterPro
comment: Atat

IPR007965
type: Resource
database: InterPro
comment: GNAT_ATAT

PTHR12327:SF0
type: Resource
database: PANTHER
comment: ALPHA-TUBULIN N-ACETYLTRANSFERASE 1
signature sequence match: PANTHER PTHR12327:SF0 match 1

PTHR12327
type: Resource
database: PANTHER
comment: UNCHARACTERIZED
signature sequence match: PANTHER PTHR12327 match 1

PF05301
type: Resource
database: Pfam
comment: Acetyltransf_16
signature sequence match: Pfam PF05301 match 1

SSF55729
type: Resource
database: SUPFAM
comment: Acyl-CoA N-acyltransferases (Nat)
signature sequence match: SUPFAM SSF55729 match 1

PS51730
type: Resource
database: PROSITE
comment: GNAT_ATAT
signature sequence match: PROSITE PS51730 match 1

SIP81A0153FE7D546C9
type: Structured Name
full name: Alpha-tubulin N-acetyltransferase
short name: Alpha-TAT
short name: TAT
ec name: 2.3.1.108

SIP8A567449DBA275AD
type: Structured Name
full name: Acetyltransferase mec-17 homolog

http://purl.uniprot.org/uniprot/A8BM50#gene-MD550A93E092BA055FAB88BF0EA7F170A9D
type: Gene
orf name: GL50803_16348

SIP1C8726D7768B9A7C
type: Function Annotation
comment: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.

SIPF9DE9B4FF7EA495D
type: Similarity Annotation
comment: Belongs to the acetyltransferase ATAT1 family.

PRO_0000402089
type: Chain Annotation
comment: Alpha-tubulin N-acetyltransferase
mass: 40672
range: 18357730900521006tt1tt362

18357730900521006tt1
type: Position
type: ExactPosition
position: 1
reference: A8BM50-1

18357730900521006tt362
type: Position
type: ExactPosition
position: 362
reference: A8BM50-1

SIPD81663EE12BA3A81
type: Domain Extent Annotation
comment: N-acetyltransferase
range: 18357730900521006tt1tt177

18357730900521006tt177
type: Position
type: ExactPosition
position: 177
reference: A8BM50-1

18357730900521006tt111
type: Position
type: ExactPosition
position: 111
reference: A8BM50-1

18357730900521006tt124
type: Position
type: ExactPosition
position: 124
reference: A8BM50-1

18357730900521006tt147
type: Position
type: ExactPosition
position: 147
reference: A8BM50-1

18357730900521006tt156
type: Position
type: ExactPosition
position: 156
reference: A8BM50-1

SIPDA8BFD239F6839BF
type: Site Annotation
comment: Crucial for catalytic activity
range: 18357730900521006tt52tt52

18357730900521006tt52
type: Position
type: ExactPosition
position: 52
reference: A8BM50-1

A8BM50-1
type: Simple Sequence
modified: 2007-11-13
version: 1
mass: 40672
value: MQFGCNVAEAFGLRRSGVVLLTDQSLRSMPLSQQKKVEIILDGMGRGSQAAQGLPSPITSLAFIRDSHHFLFLAVDEDQCLGILKGGIKHLFMLDSQNETHEMDAMCCLDFYTHETVQRRGIGTRLFRAMELHTHISAQGWAFDRPSPKLLAFLSKVYDMHDFKAQPNNFLMLDASIRLWGAEFKQYRRSKKHYIPDAYLLPETRESEYLGEAELTKRTLIRKSTAVIPQTKTTQSEDAPARALTADELLSKRSVVLPTASRTPSLPDQPQSVAAAYMNKRIEGAGPSFEQYMRDHYGAKSLIVPSEIQTSLNHSKDSVSQEDMIQRQRQLDRMAFTLAREANARGSIHNTVGRGVICGRRG

http://purl.uniprot.org/uniprot/A8BM50#attribution-8B88553134DA86160391CD6460D31035
manual: true
evidence: ECO_0000255
source: MF_03130

E2RTQ7
type: Protein
reviewed: true
created: 2023-09-13
modified: 2023-09-13
version: 64
mnemonic: AURK_GIAIC
replaces: A4KWE2
replaces: A8BBM9
citation: http://purl.uniprot.org/citations/17964578
citation: http://purl.uniprot.org/citations/17901334
citation: SIP2ED3068E824AFAA1
recommended name: SIP623CB1950DDA5EC6
alternative name: SIPC7D1E05A7CEC378F
enzyme: http://purl.uniprot.org/enzyme/2.7.11.1
organism: http://purl.uniprot.org/taxonomy/184922
annotation: SIP8CA438EFD6EFE4B2
annotation: SIP6F8707830AFB95D3
annotation: SIP33C16EDEEE02D6B9
annotation: SIP29A668754A5F6809
annotation: SIPDEF10D27BF182CC2
annotation: SIPD30621B7D0BF4744
annotation: SIP7E9D1B5628D35B34
annotation: PRO_0000458831
annotation: SIP42DF31BE006A202F
annotation: SIP468A2E3961AC5385
annotation: SIP29B2BADC74BE2695
annotation: SIP7E1019C0A0D43973
annotation: SIPD0C85A87F1311D41
annotation: SIP724B90EE7E52CC65
annotation: SIPE69688D292F870CF
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/206
classified with: http://purl.uniprot.org/keywords/498
classified with: http://purl.uniprot.org/keywords/539
classified with: http://purl.uniprot.org/keywords/597
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/723
classified with: GO_0032133
classified with: GO_0005876
classified with: GO_0051233
classified with: GO_0031616
classified with: GO_0005524
classified with: GO_0004674
classified with: GO_0007052
classified with: GO_0006468
classified with: GO_0032465
sequence: E2RTQ7-1
proteome: Chromosome 5
proteome: Unassembled WGS sequence

E2RTQ7-citation-17964578
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: FUNCTION
scope: ACTIVITY REGULATION
scope: SUBCELLULAR LOCATION
scope: REGION
scope: MOTIF
scope: PHOSPHORYLATION
scope: MUTAGENESIS OF 153-LYS--MET-180
scope: 3D-STRUCTURE MODELING

ATCC 50803 / WB clone C6
type: Strain

E2RTQ7-citation-17901334
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

E2RTQ7-citation-SIP2ED3068E824AFAA1
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

cd14007
type: Resource
database: CDD
comment: STKc_Aurora
signature sequence match: CDD cd14007 match 1

http://purl.uniprot.org/gene3d/1.10.510.10
type: Resource
database: Gene3D
comment: Transferase(Phosphotransferase) domain 1
signature sequence match: Gene3D 1.10.510.10 match 1

IPR030616
type: Resource
database: InterPro
comment: Aur-like

IPR011009
type: Resource
database: InterPro
comment: Kinase-like_dom_sf

IPR000719
type: Resource
database: InterPro
comment: Prot_kinase_dom

IPR017441
type: Resource
database: InterPro
comment: Protein_kinase_ATP_BS

IPR008271
type: Resource
database: InterPro
comment: Ser/Thr_kinase_AS

PTHR24350:SF0
type: Resource
database: PANTHER
comment: AURORA KINASE
signature sequence match: PANTHER PTHR24350:SF0 match 1

PTHR24350
type: Resource
database: PANTHER
comment: SERINE/THREONINE-PROTEIN KINASE IAL-RELATED
signature sequence match: PANTHER PTHR24350 match 1

PF00069
type: Resource
database: Pfam
comment: Pkinase
signature sequence match: Pfam PF00069 match 1

SM00220
type: Resource
database: SMART
comment: S_TKc
signature sequence match: SMART SM00220 match 1

SSF56112
type: Resource
database: SUPFAM
comment: Protein kinase-like (PK-like)
signature sequence match: SUPFAM SSF56112 match 1

PS00107
type: Resource
database: PROSITE
comment: PROTEIN_KINASE_ATP
signature sequence match: PROSITE PS00107 match 1

PS50011
type: Resource
database: PROSITE
comment: PROTEIN_KINASE_DOM
signature sequence match: PROSITE PS50011 match 1

PS00108
type: Resource
database: PROSITE
comment: PROTEIN_KINASE_ST
signature sequence match: PROSITE PS00108 match 1

SIP623CB1950DDA5EC6
type: Structured Name
full name: Aurora kinase
ec name: 2.7.11.1

SIPC7D1E05A7CEC378F
type: Structured Name
full name: gAK

http://purl.uniprot.org/uniprot/E2RTQ7#gene-MD55511E08B8F93CB31C2C454531B82DD56
type: Gene
orf name: GL50803_005358
orf name: GL50803_5358

SIP8CA438EFD6EFE4B2
type: Function Annotation
comment: Involved in regulation of the cell cycle. Required for mitotic cell division and cytokinesis. Based on its localization to centrosomes and spindle microtubules, as well as to various cytoskeletal components such as the median body, parental attachment disk, and anterior and posterior-lateral paraflagellar dense rods, may coordinate reorganization and segregation of tubulin-containing structures during mitosis and cytokinesis. May regulate microtubule disassembly by phosphorylating cytoskeletal proteins leading to their destabilization.

SIP29A668754A5F6809
type: Activity Regulation Annotation
comment: Activated by cell-cycle phase specific phosphorylation (Probable). Inhibited by ATP-competitive inhibitors N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide (ZM447439) and cyclopropanecarboxylic acid-(3-(4-(3-trifluoromethylphenylamino)-pyrimidin-2-ylamino)-phenyl)-amide (CFPPA) (PubMed:17964578). Inhibition leads to reduced growth, increased cytokinesis, microtubular defects, and increased ploidy of the cells (PubMed:17964578).

SIPDEF10D27BF182CC2
type: Subcellular Location Annotation
comment: Non-phosphorylated form is exclusively localized to both nuclei in interphase trophozoites. At the beginning of mitosis, it is mostly in the nuclei and co-localizes with chromatin through telophase. Phosphorylated form co-localizes with centrin to centrosomes from prophase through cytokinesis. Phosphorylated form localizes also to the spindle microtubules surrounding each two nuclei and the spindle poles in metaphase. It is additionally dynamically localized to cytoskeletal structures including the median body, rim of the attachment disk, and anterior and posterior-lateral paraflagellar dense rods during different stages of mitosis. Phosphorylated form remains localized to microtubules of both spindles in anaphase through telophase as the spindles elongate to allow the four nuclei segregate to opposite poles of both spindles. Phosphorylated form localizes only to the gradually unfolding parental ventral attachment disk called pontoon later in telophase and cytokinesis, but not to the two nascent daughter disks dorsal to the disassembling parental disk and spindles. Phosphorylated form localizes to the median body in all stages of mitosis, but it is less prominent after anaphase. Neither non-phosphorylated nor phosphorylated form localizes to endoplasmic reticulum, lysosome-like peripheral vesicles, mitosomes or flagellar axonemes.
located in: SIP8DD2CB379E250315
located in: SIPDC234F28EC885F54
located in: SIP873D97C0E078B1C1
located in: SIPB5BA25B1DD5EAF1C
located in: SIPB99D6ACB0203567F

SIPD30621B7D0BF4744
type: PTM Annotation
comment: Phosphorylated in mitosis and cytokinesis (PubMed:17964578). Activated by phosphorylation at Thr-205 (Probable).

SIP7E9D1B5628D35B34
type: Similarity Annotation
comment: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

PRO_0000458831
type: Chain Annotation
comment: Aurora kinase
mass: 36286
range: 19477102576351022tt1tt311

19477102576351022tt1
type: Position
type: ExactPosition
position: 1
reference: E2RTQ7-1

19477102576351022tt311
type: Position
type: ExactPosition
position: 311
reference: E2RTQ7-1

SIP42DF31BE006A202F
type: Domain Extent Annotation
comment: Protein kinase
range: 19477102576351022tt20tt300

19477102576351022tt20
type: Position
type: ExactPosition
position: 20
reference: E2RTQ7-1

19477102576351022tt300
type: Position
type: ExactPosition
position: 300
reference: E2RTQ7-1

SIP468A2E3961AC5385
type: Region Annotation
comment: Activation loop
range: 19477102576351022tt189tt216

19477102576351022tt189
type: Position
type: ExactPosition
position: 189
reference: E2RTQ7-1

19477102576351022tt216
type: Position
type: ExactPosition
position: 216
reference: E2RTQ7-1

SIP29B2BADC74BE2695
type: Motif Annotation
comment: Destruction (D)-box
range: 19477102576351022tt280tt299

19477102576351022tt280
type: Position
type: ExactPosition
position: 280
reference: E2RTQ7-1

19477102576351022tt299
type: Position
type: ExactPosition
position: 299
reference: E2RTQ7-1

SIP7E1019C0A0D43973
type: Active Site Annotation
comment: Proton acceptor
range: 19477102576351022tt143tt143

19477102576351022tt143
type: Position
type: ExactPosition
position: 143
reference: E2RTQ7-1

19477102576351022tt49
type: Position
type: ExactPosition
position: 49
reference: E2RTQ7-1

SIP724B90EE7E52CC65
type: Modified Residue Annotation
comment: Phosphothreonine
range: 19477102576351022tt205tt205

19477102576351022tt205
type: Position
type: ExactPosition
position: 205
reference: E2RTQ7-1

SIPE69688D292F870CF
type: Mutagenesis Annotation
comment: Reduced protein expression level, which may result from decreased translation efficiency or protein stability. No effect on mRNA expression level. Detected as wild-type, although only faintly, in mitotic nuclei of interphase cells, and mitotic median body and paraflagellar rods.
range: 19477102576351022tt153tt180

19477102576351022tt153
type: Position
type: ExactPosition
position: 153
reference: E2RTQ7-1

19477102576351022tt180
type: Position
type: ExactPosition
position: 180
reference: E2RTQ7-1

E2RTQ7-1
type: Simple Sequence
modified: 2010-11-30
version: 1
mass: 36286
value: MPQHLVPHTGTGKRTTIEDFEIGRFLGRGKYGLVYLAREQSSKLVVALKVLYKSYIKSERVEGQVRRELDIHLNVRHINIIRLYTWFQDETRVFLVLEVAPYGELYQRLQQFGKFPLPVVSKIIRDVAQAIQYLHRKNIFHRDLKAENILICKGKETKEHTDAHNSDDSISVHEHELVRMAHYTYKIADFGWSVHHPTHGGRRRTQCGTLDYLPPEVMLGQSYDKACDIWSLGALCYELICGTAPFYHDEIKITRQNIANVEYSFTKDFSPASKDFIQRMLIRSPEARISIEDILRHPFLRQTDHRSKVPK

http://purl.uniprot.org/uniprot/E2RTQ7#attribution-4D7F72A356C1855D0A9FA246AE0C711F
creator: GO Central
manual: true
evidence: ECO_0000318
source: http://purl.uniprot.org/citations/21873635

http://purl.uniprot.org/uniprot/E2RTQ7#attribution-637564236613379647FD0FCF5406DCB9
manual: true
evidence: ECO_0000255
source: PIRSR630616-1

http://purl.uniprot.org/uniprot/E2RTQ7#attribution-F3810522802CA1BFF5AE074D4CFB5B0B
manual: true
evidence: ECO_0000255
source: PRU00159

http://purl.uniprot.org/uniprot/E2RTQ7#attribution-13341A9ACE74F8F8AA1A063877864A47
manual: true
evidence: ECO_0000255
source: PRU10141

http://purl.uniprot.org/uniprot/E2RTQ7#attribution-D1A8061617D610FA9DFAAAC5AB9BF728
manual: true
evidence: ECO_0000255
source: RU367134

http://purl.uniprot.org/uniprot/E2RTQ7#attribution-38AF9752F2085E29403A5011AFBEF31F
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/17964578

http://purl.uniprot.org/uniprot/E2RTQ7#attribution-876D3909DAFB3A2A93EA4382FA03B522
manual: true
evidence: ECO_0000303
source: http://purl.uniprot.org/citations/17964578

http://purl.uniprot.org/uniprot/E2RTQ7#attribution-ADE9309B68FB9A23F702F8B0C004BEFA
manual: true
evidence: ECO_0000305

http://purl.uniprot.org/uniprot/E2RTQ7#attribution-A04D666F7775F027D547C9B995D38ADD
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/17964578

http://purl.uniprot.org/uniprot/E2RTQ7#attribution-C8EA51C6F6D376AE8DCBE3816A06383A
manual: true
evidence: ECO_0000312
source: ABN80997.1

http://purl.uniprot.org/uniprot/E2RTQ7#attribution-313FE367E13E34F6AD3A5E34167B0BFF
manual: true
evidence: ECO_0000312
source: EDO80342.1

http://purl.uniprot.org/uniprot/E2RTQ7#attribution-C58108BCFD0E33B344674A7CEB264563
manual: true
evidence: ECO_0000312
source: KAE8305279.1

http://purl.uniprot.org/uniprot/E2RTQ7#attribution-42AC901A915AE57D9FCF53C0C7BCAA2C
manual: true
evidence: ECO_0000312
source: UP000001548

A2EYC4
type: Protein
reviewed: true
created: 2008-04-29
modified: 2023-05-03
version: 68
mnemonic: BELY_TRIV3
old mnemonic: BELY_TRIVA
citation: http://purl.uniprot.org/citations/17218520
recommended name: SIP54B2F2C95DCA1BF9
enzyme: http://purl.uniprot.org/enzyme/4.1.99.-
organism: http://purl.uniprot.org/taxonomy/412133
annotation: SIPA1F5F75BBD1E1FF4
annotation: SIPE360C1E33031B194
annotation: PRO_0000330815
annotation: SIP31A4575A9D0AD6A9
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/456
classified with: http://purl.uniprot.org/keywords/663
classified with: http://purl.uniprot.org/keywords/1185
classified with: GO_0016830
classified with: GO_0009072
sequence: A2EYC4-1
proteome: Unassembled WGS sequence

A2EYC4-citation-17218520
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC PRA-98 / G3
type: Strain

ENOG502QU0C
type: Resource
database: eggNOG
comment: Eukaryota

cd00617
type: Resource
database: CDD
comment: Tnase_like
signature sequence match: CDD cd00617 match 1

http://purl.uniprot.org/gene3d/3.90.1150.10
type: Resource
database: Gene3D
comment: Aspartate Aminotransferase, domain 1
signature sequence match: Gene3D 3.90.1150.10 match 1

http://purl.uniprot.org/gene3d/3.40.640.10
type: Resource
database: Gene3D
comment: Type I PLP-dependent aspartate aminotransferase-like (Major domain)
signature sequence match: Gene3D 3.40.640.10 match 1

IPR001597
type: Resource
database: InterPro
comment: ArAA_b-elim_lyase/Thr_aldolase

IPR011166
type: Resource
database: InterPro
comment: Beta-eliminating_lyase

IPR015424
type: Resource
database: InterPro
comment: PyrdxlP-dep_Trfase

IPR015421
type: Resource
database: InterPro
comment: PyrdxlP-dep_Trfase_major

IPR015422
type: Resource
database: InterPro
comment: PyrdxlP-dep_Trfase_small

IPR018176
type: Resource
database: InterPro
comment: Tryptophanase_CS

PTHR32325
type: Resource
database: PANTHER
comment: BETA-ELIMINATING LYASE-LIKE PROTEIN-RELATED
signature sequence match: PANTHER PTHR32325 match 1

PTHR32325:SF4
type: Resource
database: PANTHER
comment: TRYPTOPHANASE
signature sequence match: PANTHER PTHR32325:SF4 match 1

PF01212
type: Resource
database: Pfam
comment: Beta_elim_lyase
signature sequence match: Pfam PF01212 match 1

PIRSF001386
type: Resource
database: PIRSF
comment: Trpase
signature sequence match: PIRSF PIRSF001386 match 1

SSF53383
type: Resource
database: SUPFAM
comment: PLP-dependent transferases
signature sequence match: SUPFAM SSF53383 match 1

PS00853
type: Resource
database: PROSITE
comment: BETA_ELIM_LYASE
signature sequence match: PROSITE PS00853 match 1

SIP54B2F2C95DCA1BF9
type: Structured Name
full name: Probable beta-eliminating lyase
ec name: 4.1.99.-

http://purl.uniprot.org/uniprot/A2EYC4#gene-MD50E525253D015F38BD14D8BC94F68DFB7
type: Gene
orf name: TVAG_054490

SIPE360C1E33031B194
type: Similarity Annotation
comment: Belongs to the beta-eliminating lyase family.

PRO_0000330815
type: Chain Annotation
comment: Probable beta-eliminating lyase
mass: 52097
range: 18351146917901358tt1tt458

18351146917901358tt1
type: Position
type: ExactPosition
position: 1
reference: A2EYC4-1

18351146917901358tt458
type: Position
type: ExactPosition
position: 458
reference: A2EYC4-1

SIP31A4575A9D0AD6A9
type: Modified Residue Annotation
comment: N6-(pyridoxal phosphate)lysine
range: 18351146917901358tt257tt257

18351146917901358tt257
type: Position
type: ExactPosition
position: 257
reference: A2EYC4-1

A2EYC4-1
type: Simple Sequence
modified: 2007-02-20
version: 1
mass: 52097
value: MELPFAESWKIKMVEPIHKSTREQREQWLKEAHYNVFQLTADKVYIDLLTDSGTGAMSDRQWSALMMGDESYAGASSFLKLKETITKITGFDYILPTHQGRAAENVLFSYLVKQGDIVPGNSHFDTTKGHIESRHATALDCTVDIAKDTQAEYPFKGNVDIKKLEKALEENKDKIPFIIITITNNTAGGQPVSMANLREVRELADKYKKPVLFDSARFAENAYFIKVREEGYANKTIKEICLEMFKYADGMTMSAKKDGLVNIGGFIATRLKEWYEGAKSYCIMYEGYLTYGGMAGRDMSALAAGLEENTEFEMLETRIKQVEYLAKRLDEYGIPYQRPAGGHAIFLDARKILTHVPAEEFPAQTLTVELYLEAGIRGVEIGYILADRDPVTRENRFGGLDLLRLAIPRRVYTDNHMNVVAVALKNVFDRREKITRGVKITWEAEIMRHFTVQLERLQ

http://purl.uniprot.org/uniprot/A2EYC4#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/A2EYC4#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

A8B6A2
type: Protein
reviewed: true
created: 2008-04-08
modified: 2023-06-28
version: 40
mnemonic: BIVM_GIAIC
old mnemonic: BIVM_GIAIN
old mnemonic: BIVM_GIALA
replaces: Q8MWQ6
citation: http://purl.uniprot.org/citations/17901334
recommended name: SIPEBB70815B297AF57
organism: http://purl.uniprot.org/taxonomy/184922
annotation: SIP507031FF9E4F010F
annotation: PRO_0000328959
existence: Inferred from Homology Existence
sequence: http://purl.uniprot.org/isoforms/A8B6A2-1

A8B6A2-citation-17901334
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 50803 / WB clone C6
type: Strain

SIPEBB70815B297AF57
type: Structured Name
full name: Basic immunoglobulin-like variable motif-containing protein

BIVM
type: Gene
alternative label: BIVML
orf name: GL50803_13101

SIP507031FF9E4F010F
type: Similarity Annotation
comment: Belongs to the BIVM family.

PRO_0000328959
type: Chain Annotation
comment: Basic immunoglobulin-like variable motif-containing protein
mass: 30266
range: 18357730515431982tt1tt271

18357730515431982tt1
type: Position
type: ExactPosition
position: 1
reference: http://purl.uniprot.org/isoforms/A8B6A2-1

18357730515431982tt271
type: Position
type: ExactPosition
position: 271
reference: http://purl.uniprot.org/isoforms/A8B6A2-1

http://purl.uniprot.org/isoforms/A8B6A2-1
type: Simple Sequence
modified: 2007-11-13
version: 1
mass: 30266
value: MERYPRQRLDDGRWQCVARPQYRYSCAISCLVSIFNHLFNRDMTLDECIAILFPDLKEDPRHYDFGPQASNSAVQSWFKTLCMHYGLSGTSCTIYKEQGRTRTACSKQEALKNIISALNTPRCALLYHCLNHYCIIVGYIISPSTPNRPSNHCVFSGDDGCTLKLLCADGTEAEDVDDSNIWLIVADCGKGTAPLRSLTWEFVHKDISTRPPYAYNARCPERGLLRKTESKGYIPVEIDSVLVNSTGVSTCVRSGGVIKGSSHCIIGFVSD

http://purl.uniprot.org/uniprot/A8B6A2#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

Q8MTI2
type: Protein
reviewed: true
created: 2003-11-21
modified: 2023-05-03
version: 72
mnemonic: BSL1_TRIVA
citation: http://purl.uniprot.org/citations/12467987
recommended name: SIP336A469A743D7DCF
alternative name: SIP6F92F1EA9815E45F
organism: http://purl.uniprot.org/taxonomy/5722
annotation: SIPD075CE762C9C1530
annotation: SIP1BFB9D1A7AF1C869
annotation: PRO_0000064998
annotation: SIP0076C331E34BB2B4
annotation: SIP354B4EA808EB0512
annotation: SIPEAF952F826796476
annotation: SIPD87B126091A5CEE6
annotation: SIP7FF01B721E1AE15A
annotation: SIPEB74358C1A165086
annotation: SIPFC9908130EAE9F9E
annotation: SIPBC4925B9E0F78922
annotation: SIPE5D9E13F95659D55
annotation: SIP1FC496E1313883A7
annotation: SIP18576DC1AB8E0D8C
annotation: SIPEE8907D7AC7A7C6C
annotation: SIP8B78CBE4C7FDEBC5
annotation: SIP402ED4B085086AB8
annotation: SIP866938F140745235
annotation: SIPFEE149EE18D463E3
annotation: SIPFA058B152E9F7E18
annotation: SIP774DDF736671DEBB
annotation: SIPB8D56F1F20881681
annotation: SIPCA9D62D9DAF9AD93
annotation: SIP4F4383C7048F8DA8
annotation: SIP5A9836FF0FC74304
existence: Predicted Existence
classified with: http://purl.uniprot.org/keywords/1003
classified with: http://purl.uniprot.org/keywords/325
classified with: http://purl.uniprot.org/keywords/433
classified with: http://purl.uniprot.org/keywords/677
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0005886
sequence: Q8MTI2-1

Q8MTI2-citation-12467987
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

Q8MTI2
type: Resource
database: GlyCosmos
comment: 2 sites, No reported glycans

http://purl.uniprot.org/gene3d/3.80.10.10
type: Resource
database: Gene3D
comment: Ribonuclease Inhibitor
signature sequence match: Gene3D 3.80.10.10 match 1
signature sequence match: Gene3D 3.80.10.10 match 2

IPR026906
type: Resource
database: InterPro
comment: LRR_5

IPR032675
type: Resource
database: InterPro
comment: LRR_dom_sf

PTHR45661:SF3
type: Resource
database: PANTHER
comment: ANTIGEN BSP, PUTATIVE-RELATED
signature sequence match: PANTHER PTHR45661:SF3 match 1

PTHR45661
type: Resource
database: PANTHER
comment: SURFACE ANTIGEN
signature sequence match: PANTHER PTHR45661 match 1

PF13306
type: Resource
database: Pfam
comment: LRR_5
signature sequence match: Pfam PF13306 match 1
signature sequence match: Pfam PF13306 match 2

SSF52058
type: Resource
database: SUPFAM
comment: L domain-like
signature sequence match: SUPFAM SSF52058 match 1

SIP336A469A743D7DCF
type: Structured Name
full name: Putative surface protein bspA-like

SIP6F92F1EA9815E45F
type: Structured Name
full name: TvBspA-like-625

BSPAL1
type: Gene

SIPD075CE762C9C1530
type: Function Annotation
comment: May bind host tissue.

SIP1BFB9D1A7AF1C869
type: Subcellular Location Annotation
comment: Surface membrane.
located in: SIPFA940EBE14708D32

PRO_0000064998
type: Chain Annotation
comment: Putative surface protein bspA-like
mass: 67022
range: 22861377891283502tt1tt625

22861377891283502tt1
type: Position
type: ExactPosition
position: 1
reference: Q8MTI2-1

22861377891283502tt625
type: Position
type: ExactPosition
position: 625
reference: Q8MTI2-1

SIP0076C331E34BB2B4
type: Topological Domain Annotation
comment: Extracellular
range: 22861377891283502tt1tt548

22861377891283502tt548
type: Position
type: ExactPosition
position: 548
reference: Q8MTI2-1

SIP354B4EA808EB0512
type: Transmembrane Annotation
comment: Helical
range: 22861377891283502tt549tt571

22861377891283502tt549
type: Position
type: ExactPosition
position: 549
reference: Q8MTI2-1

22861377891283502tt571
type: Position
type: ExactPosition
position: 571
reference: Q8MTI2-1

SIPEAF952F826796476
type: Topological Domain Annotation
comment: Cytoplasmic
range: 22861377891283502tt572tt625

22861377891283502tt572
type: Position
type: ExactPosition
position: 572
reference: Q8MTI2-1

SIPD87B126091A5CEE6
type: Repeat Annotation
comment: LRR 1
range: 22861377891283502tt38tt60

22861377891283502tt38
type: Position
type: ExactPosition
position: 38
reference: Q8MTI2-1

22861377891283502tt60
type: Position
type: ExactPosition
position: 60
reference: Q8MTI2-1

SIP7FF01B721E1AE15A
type: Repeat Annotation
comment: LRR 2
range: 22861377891283502tt61tt83

22861377891283502tt61
type: Position
type: ExactPosition
position: 61
reference: Q8MTI2-1

22861377891283502tt83
type: Position
type: ExactPosition
position: 83
reference: Q8MTI2-1

SIPEB74358C1A165086
type: Repeat Annotation
comment: LRR 3
range: 22861377891283502tt85tt106

22861377891283502tt85
type: Position
type: ExactPosition
position: 85
reference: Q8MTI2-1

22861377891283502tt106
type: Position
type: ExactPosition
position: 106
reference: Q8MTI2-1

SIPFC9908130EAE9F9E
type: Repeat Annotation
comment: LRR 4
range: 22861377891283502tt107tt129

22861377891283502tt107
type: Position
type: ExactPosition
position: 107
reference: Q8MTI2-1

22861377891283502tt129
type: Position
type: ExactPosition
position: 129
reference: Q8MTI2-1

SIPBC4925B9E0F78922
type: Repeat Annotation
comment: LRR 5
range: 22861377891283502tt153tt175

22861377891283502tt153
type: Position
type: ExactPosition
position: 153
reference: Q8MTI2-1

22861377891283502tt175
type: Position
type: ExactPosition
position: 175
reference: Q8MTI2-1

SIPE5D9E13F95659D55
type: Repeat Annotation
comment: LRR 6
range: 22861377891283502tt176tt198

22861377891283502tt176
type: Position
type: ExactPosition
position: 176
reference: Q8MTI2-1

22861377891283502tt198
type: Position
type: ExactPosition
position: 198
reference: Q8MTI2-1

SIP1FC496E1313883A7
type: Repeat Annotation
comment: LRR 7
range: 22861377891283502tt200tt221

22861377891283502tt200
type: Position
type: ExactPosition
position: 200
reference: Q8MTI2-1

22861377891283502tt221
type: Position
type: ExactPosition
position: 221
reference: Q8MTI2-1

SIP18576DC1AB8E0D8C
type: Repeat Annotation
comment: LRR 8
range: 22861377891283502tt222tt245

22861377891283502tt222
type: Position
type: ExactPosition
position: 222
reference: Q8MTI2-1

22861377891283502tt245
type: Position
type: ExactPosition
position: 245
reference: Q8MTI2-1

SIPEE8907D7AC7A7C6C
type: Repeat Annotation
comment: LRR 9
range: 22861377891283502tt247tt267

22861377891283502tt247
type: Position
type: ExactPosition
position: 247
reference: Q8MTI2-1

22861377891283502tt267
type: Position
type: ExactPosition
position: 267
reference: Q8MTI2-1

SIP8B78CBE4C7FDEBC5
type: Repeat Annotation
comment: LRR 10
range: 22861377891283502tt271tt293

22861377891283502tt271
type: Position
type: ExactPosition
position: 271
reference: Q8MTI2-1

22861377891283502tt293
type: Position
type: ExactPosition
position: 293
reference: Q8MTI2-1

SIP402ED4B085086AB8
type: Repeat Annotation
comment: LRR 11
range: 22861377891283502tt325tt347

22861377891283502tt325
type: Position
type: ExactPosition
position: 325
reference: Q8MTI2-1

22861377891283502tt347
type: Position
type: ExactPosition
position: 347
reference: Q8MTI2-1

SIP866938F140745235
type: Repeat Annotation
comment: LRR 12
range: 22861377891283502tt348tt368

22861377891283502tt348
type: Position
type: ExactPosition
position: 348
reference: Q8MTI2-1

22861377891283502tt368
type: Position
type: ExactPosition
position: 368
reference: Q8MTI2-1

SIPFEE149EE18D463E3
type: Repeat Annotation
comment: LRR 13
range: 22861377891283502tt369tt392

22861377891283502tt369
type: Position
type: ExactPosition
position: 369
reference: Q8MTI2-1

22861377891283502tt392
type: Position
type: ExactPosition
position: 392
reference: Q8MTI2-1

SIPFA058B152E9F7E18
type: Region Annotation
comment: Disordered
range: 22861377891283502tt439tt538

22861377891283502tt439
type: Position
type: ExactPosition
position: 439
reference: Q8MTI2-1

22861377891283502tt538
type: Position
type: ExactPosition
position: 538
reference: Q8MTI2-1

SIP774DDF736671DEBB
type: Region Annotation
comment: Disordered
range: 22861377891283502tt577tt625

22861377891283502tt577
type: Position
type: ExactPosition
position: 577
reference: Q8MTI2-1

SIPB8D56F1F20881681
type: Compositional Bias Annotation
comment: Polar residues
range: 22861377891283502tt439tt529

22861377891283502tt529
type: Position
type: ExactPosition
position: 529
reference: Q8MTI2-1

SIPCA9D62D9DAF9AD93
type: Compositional Bias Annotation
comment: Polar residues
range: 22861377891283502tt587tt625

22861377891283502tt587
type: Position
type: ExactPosition
position: 587
reference: Q8MTI2-1

SIP4F4383C7048F8DA8
type: Glycosylation Annotation
comment: N-linked (GlcNAc...) asparagine
range: 22861377891283502tt15tt15

22861377891283502tt15
type: Position
type: ExactPosition
position: 15
reference: Q8MTI2-1

SIP5A9836FF0FC74304
type: Glycosylation Annotation
comment: N-linked (GlcNAc...) asparagine
range: 22861377891283502tt227tt227

22861377891283502tt227
type: Position
type: ExactPosition
position: 227
reference: Q8MTI2-1

Q8MTI2-1
type: Simple Sequence
modified: 2002-10-01
version: 1
mass: 67022
value: MMTPGKSSKTPIVGNLTTLGITIPDTVTSIGFKTFYGCSSFTSIIIPNSVTSIGTKAFTGCSSLTSITIGNSVTSFGQEAFSECSSITSITIPNSVTTIRDFAFSGCSKLTSITIPNSVTSLGSHAFRGCSGLTSIIIPDSVTLIRGSIFYGCSSLTSITIPNSVTSIYSSAFYGCSSLTSITIPDSVLDFGSAAFQECSKLTNIKIGNNVDSIGSLAFKRCSSLTNITIPDSVTTIANSAFYECSKLTSITIGKSVTRIEGNAFSKCYSLTSITIKTTNDITSSITTDVFLNCPITELIYETTGLTFLTYEYFKDKVTLIKFNIPKSDSNSMIRLQEITSLPTLTHFTNLNKVTIENINELTIPESFIEGDNFEILITNNIKSIDPNAFKDCSINKFTYLGTDKLENDFLKNAKSCEEVITSTKYSDNEIGGMTITHKQSEENPNQPGENPNQPGENPNQPGENPNQPGENPSQPGENPSQPGENPNQPGENPSQPGENPNQPGENPNQPGENPNQPGENPSQPGENTDDPSKSKENKAIKGGEIAGIIIGSLIGICLVVAICFGVYYYFMRIKPKNKNDDNEGNQEDTIANGTNEVTNENVLATFDEQPNNESDSNGLDSAEV

http://purl.uniprot.org/uniprot/Q8MTI2#attribution-DC036A124EC8E88DF072B29F6D9BB9FE
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/Q8MTI2#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

P15799
type: Protein
reviewed: true
created: 1990-04-01
modified: 2022-12-14
version: 56
mnemonic: C170_GIAIN
old mnemonic: C170_GIALA
citation: http://purl.uniprot.org/citations/3335828
recommended name: SIPC3F5ABE041D1B197
organism: http://purl.uniprot.org/taxonomy/5741
annotation: SIP0EF4C6EF0E1AA1B5
annotation: PRO_0000065037
annotation: SIP9A7AF73B29E48C91
annotation: SIP198A1B2F68240704
annotation: SIPB1648B5C712C6A61
annotation: SIP6587F0932039F5E3
existence: Predicted Existence
classified with: http://purl.uniprot.org/keywords/677
sequence: P15799-1

P15799-citation-3335828
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

ATCC 30957 / WB
type: Strain

KOG3525
type: Resource
database: eggNOG
comment: Eukaryota

IPR006212
type: Resource
database: InterPro
comment: Furin_repeat

IPR009030
type: Resource
database: InterPro
comment: Growth_fac_rcpt_cys_sf

SM00261
type: Resource
database: SMART
comment: FU
signature sequence match: SMART SM00261 match 1
signature sequence match: SMART SM00261 match 2
signature sequence match: SMART SM00261 match 3
signature sequence match: SMART SM00261 match 4
signature sequence match: SMART SM00261 match 5
signature sequence match: SMART SM00261 match 6

SSF57184
type: Resource
database: SUPFAM
comment: Growth factor receptor domain
signature sequence match: SUPFAM SSF57184 match 1
signature sequence match: SUPFAM SSF57184 match 2
signature sequence match: SUPFAM SSF57184 match 3
signature sequence match: SUPFAM SSF57184 match 4

SIPC3F5ABE041D1B197
type: Structured Name
full name: Surface antigen CRP170

SIP0EF4C6EF0E1AA1B5
type: Annotation
comment: Cysteine-rich, antigenically variant surface protein.

PRO_0000065037
type: Chain Annotation
comment: Surface antigen CRP170
mass: 33439
range: 22572102766377262tf1tf328

22572102766377262tt1
type: Position
type: ExactPosition
position: 1
reference: P15799-1

22572102766377262tt328
type: Position
type: ExactPosition
position: 328
reference: P15799-1

22572102766377262tt38
type: Position
type: ExactPosition
position: 38
reference: P15799-1

22572102766377262tt102
type: Position
type: ExactPosition
position: 102
reference: P15799-1

22572102766377262tt103
type: Position
type: ExactPosition
position: 103
reference: P15799-1

22572102766377262tt167
type: Position
type: ExactPosition
position: 167
reference: P15799-1

P15799-1
type: Simple Sequence
modified: 1990-04-01
version: 1
fragment: single
mass: 33439
value: TNPSDPTGTCVSAVDCQGSAGYYTDDSVSDAKECKKCNAPCTACAGTADKCTKCDANGAAPYLKKTNPSDPTGTCVSAVDCQGSAGYYTDDSVSDAKECKKCNAPCTACAGTADKCTKCDANGAAPYLKKTNPSDPTGTCVSAVDCQGSAGYYTDDSVSDAKECKKCAEGQKPNTAGTQCFSCSDANCERCDQNDVCARCSTGAPPENGKCPAATPGCHSSCDGCTENAMTNQADKCTGCKEGRYLKPESAAGQSGACLTAEECTSDKTHFTREKAGDSKGMCLSCSDATHGITGCKKCALKTLSGEAESTVVCSECTDKRLTPSGNA

Q01832
type: Protein
reviewed: true
created: 1994-06-01
modified: 2023-06-28
version: 36
mnemonic: C4_GIAIN
old mnemonic: C4_GIALA
citation: http://purl.uniprot.org/citations/1493870
recommended name: SIP6ECF929CDBEF01D0
organism: http://purl.uniprot.org/taxonomy/5741
annotation: SIP18B5EC57CA8A81CE
annotation: PRO_0000089244
annotation: SIP8E061D351D0B5C5F
existence: Predicted Existence
sequence: MFNPRHPGGEFFGRKHHRRHAPDGRSSSSSSSSSECELGYDERRCCRQEPDAHCCDREHRKFWKHPPEFPHFGKCKGRHALPFPRMEHWPGPKHCPFLSEKDMKDLPVTVHHGCMPIVAHGVVMFHIVSETKPSITISNTGAIKVEANGIQLLSASLKEKYPVDKVVASYANKIATIRIPCDAAFSESPVDIPITIQK

Q01832-citation-1493870
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

IPR035226
type: Resource
database: InterPro
comment: DUF5450

PF17529
type: Resource
database: Pfam
comment: DUF5450
signature sequence match: Pfam PF17529 match 1

SIP6ECF929CDBEF01D0
type: Structured Name
full name: Protein C4

C4
type: Gene

SIP18B5EC57CA8A81CE
type: Annotation
comment: This protein is found only in group 3 isolates.

PRO_0000089244
type: Chain Annotation
comment: Protein C4
mass: 22299
range: 22852461067973166tt1tt198

22852461067973166tt1
type: Position
type: ExactPosition
position: 1
reference: MFNPRHPGGEFFGRKHHRRHAPDGRSSSSSSSSSECELGYDERRCCRQEPDAHCCDREHRKFWKHPPEFPHFGKCKGRHALPFPRMEHWPGPKHCPFLSEKDMKDLPVTVHHGCMPIVAHGVVMFHIVSETKPSITISNTGAIKVEANGIQLLSASLKEKYPVDKVVASYANKIATIRIPCDAAFSESPVDIPITIQK

22852461067973166tt198
type: Position
type: ExactPosition
position: 198
reference: MFNPRHPGGEFFGRKHHRRHAPDGRSSSSSSSSSECELGYDERRCCRQEPDAHCCDREHRKFWKHPPEFPHFGKCKGRHALPFPRMEHWPGPKHCPFLSEKDMKDLPVTVHHGCMPIVAHGVVMFHIVSETKPSITISNTGAIKVEANGIQLLSASLKEKYPVDKVVASYANKIATIRIPCDAAFSESPVDIPITIQK

SIP8E061D351D0B5C5F
type: Region Annotation
comment: Disordered
range: 22852461067973166tt1tt36

22852461067973166tt36
type: Position
type: ExactPosition
position: 36
reference: MFNPRHPGGEFFGRKHHRRHAPDGRSSSSSSSSSECELGYDERRCCRQEPDAHCCDREHRKFWKHPPEFPHFGKCKGRHALPFPRMEHWPGPKHCPFLSEKDMKDLPVTVHHGCMPIVAHGVVMFHIVSETKPSITISNTGAIKVEANGIQLLSASLKEKYPVDKVVASYANKIATIRIPCDAAFSESPVDIPITIQK

MFNPRHPGGEFFGRKHHRRHAPDGRSSSSSSSSSECELGYDERRCCRQEPDAHCCDREHRKFWKHPPEFPHFGKCKGRHALPFPRMEHWPGPKHCPFLSEKDMKDLPVTVHHGCMPIVAHGVVMFHIVSETKPSITISNTGAIKVEANGIQLLSASLKEKYPVDKVVASYANKIATIRIPCDAAFSESPVDIPITIQK
type: Simple Sequence
modified: 1994-06-01
version: 1
mass: 22299

P92131
type: Protein
reviewed: true
created: 2003-06-16
modified: 2023-06-28
version: 92
mnemonic: CATB1_GIAIN
old mnemonic: CABL1_GIALA
old mnemonic: CAL1_GIALA
old mnemonic: CATB1_GIALA
replaces: Q9GP25
citation: http://purl.uniprot.org/citations/9150143
citation: http://purl.uniprot.org/citations/11849701
citation: SIPA800E4D8CBEA28CA
conflicting sequence: SIP470182396A77B1F3
conflicting sequence: SIP404ED5CB7691FF8D
recommended name: SIPD85704A63721BFE5
alternative name: SIP59520AF69A228C54
enzyme: http://purl.uniprot.org/enzyme/3.4.22.-
organism: http://purl.uniprot.org/taxonomy/5741
annotation: SIP88C3E00815644B7E
annotation: SIPDE42028276DB8393
annotation: SIPCFF5193C82A61439
annotation: SIPCAB2996CB7CB1C79
annotation: SIP148F2D48722134FC
annotation: SIP716C7684B3D22E8F
annotation: SIP4CCC899EB75398CE
annotation: PRO_0000026164
annotation: PRO_0000026165
annotation: SIPB0C1C00F9FC983EE
annotation: SIP2E4180E4E8A105A8
annotation: SIP8F6FBBD6DA071D70
annotation: SIP751CB60ACA2E8BF4
annotation: SIP2F565C713871C0C7
annotation: SIPF679A685B1A4B52A
annotation: SIP3E7C22903A80F192
annotation: SIP44BB93DA542CD551
annotation: SIP3927DE188EFE5D52
existence: Evidence at Transcript Level Existence
classified with: http://purl.uniprot.org/keywords/1015
classified with: http://purl.uniprot.org/keywords/325
classified with: http://purl.uniprot.org/keywords/732
classified with: http://purl.uniprot.org/keywords/788
classified with: http://purl.uniprot.org/keywords/926
classified with: http://purl.uniprot.org/keywords/865
classified with: GO_0005773
classified with: GO_0008234
classified with: GO_0006508
sequence: P92131-1

P92131-citation-9150143
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: FUNCTION
scope: SUBCELLULAR LOCATION
scope: INDUCTION

ATCC 30957 / WB
type: Strain

P92131-citation-11849701
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

SIPA800E4D8CBEA28CA
type: Observation Citation
author: Sajid M.
date: 2003-06

P92131-citation-SIPA800E4D8CBEA28CA
type: Citation Statement
scope: SEQUENCE REVISION

EMBL AAB58258.1
comment: Different initiation.

P92131
type: Resource
database: GlyCosmos
comment: 1 site, No reported glycans

KOG1543
type: Resource
database: eggNOG
comment: Eukaryota

cd02620
type: Resource
database: CDD
comment: Peptidase_C1A_CathepsinB
signature sequence match: CDD cd02620 match 1

http://purl.uniprot.org/gene3d/3.90.70.10
type: Resource
database: Gene3D
comment: Cysteine proteinases
signature sequence match: Gene3D 3.90.70.10 match 1

IPR038765
type: Resource
database: InterPro
comment: Papain-like_cys_pep_sf

IPR025661
type: Resource
database: InterPro
comment: Pept_asp_AS

IPR000169
type: Resource
database: InterPro
comment: Pept_cys_AS

IPR025660
type: Resource
database: InterPro
comment: Pept_his_AS

IPR013128
type: Resource
database: InterPro
comment: Peptidase_C1A

IPR000668
type: Resource
database: InterPro
comment: Peptidase_C1A_C

PTHR12411
type: Resource
database: PANTHER
comment: CYSTEINE PROTEASE FAMILY C1-RELATED
signature sequence match: PANTHER PTHR12411 match 1

PTHR12411:SF741
type: Resource
database: PANTHER
comment: RE20049P
signature sequence match: PANTHER PTHR12411:SF741 match 1

PF00112
type: Resource
database: Pfam
comment: Peptidase_C1
signature sequence match: Pfam PF00112 match 1

PR00705
type: Resource
database: PRINTS
comment: PAPAIN

SM00645
type: Resource
database: SMART
comment: Pept_C1
signature sequence match: SMART SM00645 match 1

SSF54001
type: Resource
database: SUPFAM
comment: Cysteine proteinases
signature sequence match: SUPFAM SSF54001 match 1

PS00640
type: Resource
database: PROSITE
comment: THIOL_PROTEASE_ASN
signature sequence match: PROSITE PS00640 match 1

PS00139
type: Resource
database: PROSITE
comment: THIOL_PROTEASE_CYS
signature sequence match: PROSITE PS00139 match 1

PS00639
type: Resource
database: PROSITE
comment: THIOL_PROTEASE_HIS
signature sequence match: PROSITE PS00639 match 1

SIPD85704A63721BFE5
type: Structured Name
full name: Cathepsin B-like CP1
ec name: 3.4.22.-

SIP59520AF69A228C54
type: Structured Name
full name: Cathepsin B-like protease B1

CP1
type: Gene

SIP88C3E00815644B7E
type: Function Annotation
comment: Thiol protease which is required for parasite excystation and invasion of the proximal small intestine of the human host.

SIPCFF5193C82A61439
type: Developmental Stage Annotation
comment: To initiate infection, trophozoites emerge from a cyst in the host. Excystation is blocked by specific cysteine protease inhibitors. Vacuoles release it just prior to excystation.

SIPCAB2996CB7CB1C79
type: Induction Annotation
comment: Not expressed without supplemental iron.

SIP148F2D48722134FC
type: Similarity Annotation
comment: Belongs to the peptidase C1 family.

22580885873439022tt1
type: Position
type: ExactPosition
position: 1
reference: P92131-1

22580885873439022tt19
type: Position
type: ExactPosition
position: 19
reference: P92131-1

PRO_0000026164
type: Propeptide Annotation
comment: Activation peptide
range: 22580885873439022tt20ne

22580885873439022tt20
type: Position
type: ExactPosition
position: 20
reference: P92131-1

PRO_0000026165
type: Chain Annotation
comment: Cathepsin B-like CP1
mass: 33508
range: 22580885873439022nbtt303

22580885873439022tt303
type: Position
type: ExactPosition
position: 303
reference: P92131-1

22580885873439022tt105
type: Position
type: ExactPosition
position: 105
reference: P92131-1

22580885873439022tt249
type: Position
type: ExactPosition
position: 249
reference: P92131-1

22580885873439022tt270
type: Position
type: ExactPosition
position: 270
reference: P92131-1

SIP751CB60ACA2E8BF4
type: Glycosylation Annotation
comment: N-linked (GlcNAc...) asparagine
range: 22580885873439022tt41tt41

22580885873439022tt41
type: Position
type: ExactPosition
position: 41
reference: P92131-1

22580885873439022tt92
type: Position
type: ExactPosition
position: 92
reference: P92131-1

22580885873439022tt119
type: Position
type: ExactPosition
position: 119
reference: P92131-1

22580885873439022tt102
type: Position
type: ExactPosition
position: 102
reference: P92131-1

22580885873439022tt145
type: Position
type: ExactPosition
position: 145
reference: P92131-1

22580885873439022tt138
type: Position
type: ExactPosition
position: 138
reference: P92131-1

22580885873439022tt181
type: Position
type: ExactPosition
position: 181
reference: P92131-1

SIP44BB93DA542CD551
type: Sequence Conflict Annotation
conflicting sequence: SIP470182396A77B1F3
substitution: E
range: 22580885873439022tt104tt104

22580885873439022tt104
type: Position
type: ExactPosition
position: 104
reference: P92131-1

SIP3927DE188EFE5D52
type: Sequence Conflict Annotation
conflicting sequence: SIP404ED5CB7691FF8D
substitution: E
range: 22580885873439022tt104tt104

P92131-1
type: Simple Sequence
modified: 2003-06-16
version: 3
precursor: true
mass: 33508
value: MALSLLLAVVCAKPLVSRAELRRIQALNPPWKAGMPKRFENVTEDEFRSMLIRPDRLRARSGSLPPISITEVQELVDPIPPQFDFRDEYPQCVKPALDQGSCGSCWAFSAIGVFGDRRCAMGIDKEAVSYSQQHLISCSLENFGCDGGDFQPTWSFLTFTGATTAECVKYVDYGHTVASPCPAVCDDGSPIQLYKAHGYGQVSKSVPAIMGMLVAGGPLQTMIVVYADLSYYESGVYKHTYGTINLGFHALEIVGYGTTDDGTDYWIIKNSWGPDWGENGYFRIVRGVNECRIEDEIYAVYLD

http://purl.uniprot.org/uniprot/P92131#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/P92131#attribution-DC036A124EC8E88DF072B29F6D9BB9FE
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/P92131#attribution-28428EF056A8E20E0D4A5A73CDC590CB
manual: true
evidence: ECO_0000255
source: PRU10088

http://purl.uniprot.org/uniprot/P92131#attribution-4EE29B77D2645F25A6F24BE62783D881
manual: true
evidence: ECO_0000255
source: PRU10089

http://purl.uniprot.org/uniprot/P92131#attribution-F99589090D3A9D37BF3B4263A0E69596
manual: true
evidence: ECO_0000255
source: PRU10090

http://purl.uniprot.org/uniprot/P92131#attribution-58739822BD3BEBA46D08B069B4EBDC56
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/9150143

http://purl.uniprot.org/uniprot/P92131#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

P92132
type: Protein
reviewed: true
created: 2003-06-16
modified: 2023-06-28
version: 88
mnemonic: CATB2_GIAIN
old mnemonic: CABL2_GIALA
old mnemonic: CAL2_GIALA
old mnemonic: CATB2_GIALA
replaces: Q9GP24
citation: http://purl.uniprot.org/citations/11849701
citation: http://purl.uniprot.org/citations/9150143
recommended name: SIP54F0F1F2F7CE477C
alternative name: SIPEB7C0ED769851E77
enzyme: http://purl.uniprot.org/enzyme/3.4.22.-
organism: http://purl.uniprot.org/taxonomy/5741
annotation: SIPB67755DB8D855BF8
annotation: SIP94E2AA78649533DF
annotation: SIP9085C1BC4B444681
annotation: SIP32CA8027424AFA95
annotation: SIP08E594301CC28248
annotation: PRO_0000026166
annotation: PRO_0000026167
annotation: SIP13CAFFD024D59B18
annotation: SIP092D2AD71B6E5064
annotation: SIPD78FED61D2C20C72
annotation: SIPEFE4B6986D463031
annotation: SIPE116DC3F2166342F
annotation: SIP326145BB36B4A591
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/1015
classified with: http://purl.uniprot.org/keywords/732
classified with: http://purl.uniprot.org/keywords/788
classified with: http://purl.uniprot.org/keywords/926
classified with: http://purl.uniprot.org/keywords/865
classified with: GO_0005773
classified with: GO_0008234
classified with: GO_0006508
sequence: P92132-1

P92132-citation-11849701
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

ATCC 30957 / WB
type: Strain

P92132-citation-9150143
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 71-268
scope: PROTEIN SEQUENCE OF 71-84
scope: FUNCTION
scope: SUBCELLULAR LOCATION
scope: DEVELOPMENTAL STAGE

SIP54F0F1F2F7CE477C
type: Structured Name
full name: Cathepsin B-like CP2
ec name: 3.4.22.-

SIPEB7C0ED769851E77
type: Structured Name
full name: Cathepsin B-like protease B2

CP2
type: Gene

SIPB67755DB8D855BF8
type: Function Annotation
comment: Thiol protease which is required for parasite excystation and invasion of the proximal small intestine of the human host.

SIP9085C1BC4B444681
type: Developmental Stage Annotation
comment: To initiate infection, trophozoites emerge from a cyst in the host. Excystation is blocked by specific cysteine protease inhibitors. Vacuoles release it just prior to excystation. Expressed in replicating and encysting trophozoites without supplemental iron.

SIP32CA8027424AFA95
type: Similarity Annotation
comment: Belongs to the peptidase C1 family.

22580885873439278tt1
type: Position
type: ExactPosition
position: 1
reference: P92132-1

22580885873439278tt19
type: Position
type: ExactPosition
position: 19
reference: P92132-1

PRO_0000026166
type: Propeptide Annotation
comment: Activation peptide
range: 22580885873439278tt20ne

22580885873439278tt20
type: Position
type: ExactPosition
position: 20
reference: P92132-1

PRO_0000026167
type: Chain Annotation
comment: Cathepsin B-like CP2
mass: 33002
range: 22580885873439278nbtt300

22580885873439278tt300
type: Position
type: ExactPosition
position: 300
reference: P92132-1

22580885873439278tt101
type: Position
type: ExactPosition
position: 101
reference: P92132-1

22580885873439278tt245
type: Position
type: ExactPosition
position: 245
reference: P92132-1

22580885873439278tt266
type: Position
type: ExactPosition
position: 266
reference: P92132-1

22580885873439278tt88
type: Position
type: ExactPosition
position: 88
reference: P92132-1

22580885873439278tt115
type: Position
type: ExactPosition
position: 115
reference: P92132-1

22580885873439278tt98
type: Position
type: ExactPosition
position: 98
reference: P92132-1

22580885873439278tt141
type: Position
type: ExactPosition
position: 141
reference: P92132-1

22580885873439278tt134
type: Position
type: ExactPosition
position: 134
reference: P92132-1

22580885873439278tt177
type: Position
type: ExactPosition
position: 177
reference: P92132-1

P92132-1
type: Simple Sequence
modified: 2003-06-16
version: 2
precursor: true
mass: 33002
value: MKLFLLAAAAFSAPALTVSELNHIKSLNPRWKAGIPKRFEGLTKDEISSLLMPVSFLKNAKGAAPRGTFTDKDDVPESFDFREEYPHCIPEVVDQGGCGSCWAFSSVATFGDRRCVAGLDKKPVKYSPQYVVSCDHGDMACNGGWLPNVWKFLTKTGTTTDECVPYKSGSTTLRGTCPTKCADGSSKVHLATATSYKDYGLDIPAMMKALSTSGPLQVAFLVHSDFMYYESGVYQHTYGYMEGGHAVEMVGYGTDDDGVDYWIIKNSWGPDWGEDGYFRMIRGINDCSIEEQAYAGFFDE

http://purl.uniprot.org/uniprot/P92132#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/P92132#attribution-DC036A124EC8E88DF072B29F6D9BB9FE
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/P92132#attribution-28428EF056A8E20E0D4A5A73CDC590CB
manual: true
evidence: ECO_0000255
source: PRU10088

http://purl.uniprot.org/uniprot/P92132#attribution-4EE29B77D2645F25A6F24BE62783D881
manual: true
evidence: ECO_0000255
source: PRU10089

http://purl.uniprot.org/uniprot/P92132#attribution-F99589090D3A9D37BF3B4263A0E69596
manual: true
evidence: ECO_0000255
source: PRU10090

http://purl.uniprot.org/uniprot/P92132#attribution-58739822BD3BEBA46D08B069B4EBDC56
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/9150143

P92133
type: Protein
reviewed: true
created: 2003-06-16
modified: 2023-06-28
version: 84
mnemonic: CATB3_GIAIN
old mnemonic: CABL3_GIALA
old mnemonic: CAL3_GIALA
old mnemonic: CATB3_GIALA
replaces: Q9GP23
citation: http://purl.uniprot.org/citations/9150143
citation: http://purl.uniprot.org/citations/11849701
recommended name: SIP4C71FDD648FEBD83
alternative name: SIPF6C5CE7A1647C058
enzyme: http://purl.uniprot.org/enzyme/3.4.22.-
organism: http://purl.uniprot.org/taxonomy/5741
annotation: SIP6399780015BCC47B
annotation: SIPCD4A59E450EA9419
annotation: SIP999E1086543BD1B0
annotation: SIPF48D6CD1D2FA30FC
annotation: SIPF2AF8B9E594FC9B5
annotation: PRO_0000026168
annotation: PRO_0000026169
annotation: SIP37BA64B2393091A7
annotation: SIP01A64AD0D2389415
annotation: SIP8A0D60D0F5E70BEB
annotation: SIPED42ED2A68563333
annotation: SIP706CA1A0FD566471
annotation: SIP93A4E88CEA0FF55D
existence: Evidence at Transcript Level Existence
classified with: http://purl.uniprot.org/keywords/1015
classified with: http://purl.uniprot.org/keywords/732
classified with: http://purl.uniprot.org/keywords/788
classified with: http://purl.uniprot.org/keywords/926
classified with: http://purl.uniprot.org/keywords/865
classified with: GO_0005773
classified with: GO_0008234
classified with: GO_0006508
sequence: P92133-1

P92133-citation-9150143
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: FUNCTION
scope: SUBCELLULAR LOCATION
scope: DEVELOPMENTAL STAGE

ATCC 30957 / WB
type: Strain

P92133-citation-11849701
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

SIP4C71FDD648FEBD83
type: Structured Name
full name: Cathepsin B-like CP3
ec name: 3.4.22.-

SIPF6C5CE7A1647C058
type: Structured Name
full name: Cathepsin B-like protease B3

CP3
type: Gene

SIP6399780015BCC47B
type: Function Annotation
comment: Thiol protease which is required for parasite excystation and invasion of the proximal small intestine of the human host.

SIP999E1086543BD1B0
type: Developmental Stage Annotation
comment: To initiate infection, trophozoites emerge from a cyst in the host. Excystation is blocked by specific cysteine protease inhibitors. Vacuoles release it just prior to excystation. Expressed in replicating and encysting trophozoites without supplemental iron.

SIPF48D6CD1D2FA30FC
type: Similarity Annotation
comment: Belongs to the peptidase C1 family.

22580885873439534tt1
type: Position
type: ExactPosition
position: 1
reference: P92133-1

22580885873439534tt19
type: Position
type: ExactPosition
position: 19
reference: P92133-1

PRO_0000026168
type: Propeptide Annotation
comment: Activation peptide
range: 22580885873439534tt20ne

22580885873439534tt20
type: Position
type: ExactPosition
position: 20
reference: P92133-1

PRO_0000026169
type: Chain Annotation
comment: Cathepsin B-like CP3
mass: 32674
range: 22580885873439534nbtt299

22580885873439534tt299
type: Position
type: ExactPosition
position: 299
reference: P92133-1

22580885873439534tt100
type: Position
type: ExactPosition
position: 100
reference: P92133-1

22580885873439534tt244
type: Position
type: ExactPosition
position: 244
reference: P92133-1

22580885873439534tt265
type: Position
type: ExactPosition
position: 265
reference: P92133-1

22580885873439534tt87
type: Position
type: ExactPosition
position: 87
reference: P92133-1

22580885873439534tt114
type: Position
type: ExactPosition
position: 114
reference: P92133-1

22580885873439534tt97
type: Position
type: ExactPosition
position: 97
reference: P92133-1

22580885873439534tt140
type: Position
type: ExactPosition
position: 140
reference: P92133-1

22580885873439534tt133
type: Position
type: ExactPosition
position: 133
reference: P92133-1

22580885873439534tt176
type: Position
type: ExactPosition
position: 176
reference: P92133-1

P92133-1
type: Simple Sequence
modified: 2003-06-16
version: 2
precursor: true
mass: 32674
value: MKLFLLAAAAFSAPALTVSELNHIKSLNPRWKAGIPKRFEGLTKDEISSLLMPVSFLKRDRAAVPRGTVSATQAPDSFDFREEYPHCIPEVVDQGGCGSCWAFSSVASVGDRRCFAGLDKKAVKYSPQYVVSCDRGDMACDGGWLPSVWRFLTKTGTTTDECVPYQSGSTGARGTCPTKCADGSDLPHLYKATKAVDYGLDAPAIMKALATGGPLQTAFTVYSDFMYYESGVYQHTYGRVEGGHAVDMVGYGTDDDGVDYWIIKNSWGPDWGEDGYFRIIRMTNECGIEEQVIGGFFEN

http://purl.uniprot.org/uniprot/P92133#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/P92133#attribution-DC036A124EC8E88DF072B29F6D9BB9FE
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/P92133#attribution-28428EF056A8E20E0D4A5A73CDC590CB
manual: true
evidence: ECO_0000255
source: PRU10088

http://purl.uniprot.org/uniprot/P92133#attribution-4EE29B77D2645F25A6F24BE62783D881
manual: true
evidence: ECO_0000255
source: PRU10089

http://purl.uniprot.org/uniprot/P92133#attribution-F99589090D3A9D37BF3B4263A0E69596
manual: true
evidence: ECO_0000255
source: PRU10090

http://purl.uniprot.org/uniprot/P92133#attribution-58739822BD3BEBA46D08B069B4EBDC56
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/9150143

Q24956
type: Protein
reviewed: true
created: 1997-11-01
modified: 2023-06-28
version: 96
mnemonic: CATR_GIAIN
old mnemonic: CATR_GIALA
citation: http://purl.uniprot.org/citations/8844677
recommended name: SIP4EA14BADF8215F28
alternative name: SIP9489B9B0D7ABCB89
organism: http://purl.uniprot.org/taxonomy/5741
annotation: SIP4659FCBD25249471
annotation: SIPA32BB50DE6365B10
annotation: SIPCB7D88A7BF4BB950
annotation: SIPB7BC719F55A447B6
annotation: SIPFAA2CE624D77C330
annotation: PRO_0000073565
annotation: SIP304195F36870B1DA
annotation: SIPAEE411F896C26C9A
annotation: SIP26C822D849FCF281
annotation: SIP63B7F6661F040A44
annotation: SIP2730A0DBCF818CDA
annotation: SIP8B37A1745FFCEB67
annotation: SIP61EE1FA4D3848838
annotation: SIP6207E62703C6B96B
annotation: SIP3A775DBC7DE12744
annotation: SIPF8B3CB49872EF6DB
annotation: SIP43241F490415B6BB
annotation: SIP2E4F50E3F2D187D5
annotation: SIP63C50EC042636291
annotation: SIPD691235DD81DE76A
annotation: SIPEEA3A544DBC4EFD3
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/106
classified with: http://purl.uniprot.org/keywords/206
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/498
classified with: http://purl.uniprot.org/keywords/677
classified with: GO_0005737
classified with: GO_0005815
classified with: GO_0005509
classified with: GO_0007049
classified with: GO_0051301
sequence: MNRAAIAAGKPSGSISTGKPRRKTRAEVSEEMKHEIREAFDLFDADRSGRIDFHELKVAMRALGFDVKKEEIQRIMNEYDRDQLGEITFQDFEEVMIEKISNRDPTEEILKAFRLFDDDATGRISLKNLRRVAKELSENISDEELLAMIQEFDRDGDGEIDEEDFIAILRSTSAFS

Q24956-citation-8844677
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

ATCC 30957 / WB
type: Strain

KOG0028
type: Resource
database: eggNOG
comment: Eukaryota

cd00051
type: Resource
database: CDD
comment: EFh
signature sequence match: CDD cd00051 match 1
signature sequence match: CDD cd00051 match 2

http://purl.uniprot.org/gene3d/1.10.238.10
type: Resource
database: Gene3D
comment: EF-hand
signature sequence match: Gene3D 1.10.238.10 match 1
signature sequence match: Gene3D 1.10.238.10 match 2

IPR011992
type: Resource
database: InterPro
comment: EF-hand-dom_pair

IPR018247
type: Resource
database: InterPro
comment: EF_Hand_1_Ca_BS

IPR002048
type: Resource
database: InterPro
comment: EF_hand_dom

PTHR23050
type: Resource
database: PANTHER
comment: CALCIUM BINDING PROTEIN
signature sequence match: PANTHER PTHR23050 match 1

PTHR23050:SF325
type: Resource
database: PANTHER
comment: CENTRIN-3
signature sequence match: PANTHER PTHR23050:SF325 match 1

PF13499
type: Resource
database: Pfam
comment: EF-hand_7
signature sequence match: Pfam PF13499 match 1
signature sequence match: Pfam PF13499 match 2

SM00054
type: Resource
database: SMART
comment: EFh
signature sequence match: SMART SM00054 match 1
signature sequence match: SMART SM00054 match 2
signature sequence match: SMART SM00054 match 3
signature sequence match: SMART SM00054 match 4

SSF47473
type: Resource
database: SUPFAM
comment: EF-hand
signature sequence match: SUPFAM SSF47473 match 1

PS00018
type: Resource
database: PROSITE
comment: EF_HAND_1
signature sequence match: PROSITE PS00018 match 1
signature sequence match: PROSITE PS00018 match 2

PS50222
type: Resource
database: PROSITE
comment: EF_HAND_2
signature sequence match: PROSITE PS50222 match 1
signature sequence match: PROSITE PS50222 match 2
signature sequence match: PROSITE PS50222 match 3
signature sequence match: PROSITE PS50222 match 4

SIP4EA14BADF8215F28
type: Structured Name
full name: Caltractin

SIP9489B9B0D7ABCB89
type: Structured Name
full name: Centrin

CAL
type: Gene

SIP4659FCBD25249471
type: Function Annotation
comment: Plays a fundamental role in microtubule-organizing center structure and function.

SIPA32BB50DE6365B10
type: Subunit Annotation
comment: Monomer.

SIPCB7D88A7BF4BB950
type: Subcellular Location Annotation
comment: Centrosome of interphase and mitotic cells.
located in: SIP68DB0AB2FAD4A554

SIPB7BC719F55A447B6
type: Annotation
comment: Binds two moles of calcium per mole of protein.

SIPFAA2CE624D77C330
type: Similarity Annotation
comment: Belongs to the centrin family.

PRO_0000073565
type: Chain Annotation
comment: Caltractin
mass: 20238
range: 22854672993039918tt1tt176

22854672993039918tt1
type: Position
type: ExactPosition
position: 1
reference: MNRAAIAAGKPSGSISTGKPRRKTRAEVSEEMKHEIREAFDLFDADRSGRIDFHELKVAMRALGFDVKKEEIQRIMNEYDRDQLGEITFQDFEEVMIEKISNRDPTEEILKAFRLFDDDATGRISLKNLRRVAKELSENISDEELLAMIQEFDRDGDGEIDEEDFIAILRSTSAFS

22854672993039918tt176
type: Position
type: ExactPosition
position: 176
reference: MNRAAIAAGKPSGSISTGKPRRKTRAEVSEEMKHEIREAFDLFDADRSGRIDFHELKVAMRALGFDVKKEEIQRIMNEYDRDQLGEITFQDFEEVMIEKISNRDPTEEILKAFRLFDDDATGRISLKNLRRVAKELSENISDEELLAMIQEFDRDGDGEIDEEDFIAILRSTSAFS

SIP304195F36870B1DA
type: Domain Extent Annotation
comment: EF-hand 1
range: 22854672993039918tt31tt66

22854672993039918tt31
type: Position
type: ExactPosition
position: 31
reference: MNRAAIAAGKPSGSISTGKPRRKTRAEVSEEMKHEIREAFDLFDADRSGRIDFHELKVAMRALGFDVKKEEIQRIMNEYDRDQLGEITFQDFEEVMIEKISNRDPTEEILKAFRLFDDDATGRISLKNLRRVAKELSENISDEELLAMIQEFDRDGDGEIDEEDFIAILRSTSAFS

22854672993039918tt66
type: Position
type: ExactPosition
position: 66
reference: MNRAAIAAGKPSGSISTGKPRRKTRAEVSEEMKHEIREAFDLFDADRSGRIDFHELKVAMRALGFDVKKEEIQRIMNEYDRDQLGEITFQDFEEVMIEKISNRDPTEEILKAFRLFDDDATGRISLKNLRRVAKELSENISDEELLAMIQEFDRDGDGEIDEEDFIAILRSTSAFS

SIPAEE411F896C26C9A
type: Domain Extent Annotation
comment: EF-hand 2
range: 22854672993039918tt67tt102

22854672993039918tt67
type: Position
type: ExactPosition
position: 67
reference: MNRAAIAAGKPSGSISTGKPRRKTRAEVSEEMKHEIREAFDLFDADRSGRIDFHELKVAMRALGFDVKKEEIQRIMNEYDRDQLGEITFQDFEEVMIEKISNRDPTEEILKAFRLFDDDATGRISLKNLRRVAKELSENISDEELLAMIQEFDRDGDGEIDEEDFIAILRSTSAFS

22854672993039918tt102
type: Position
type: ExactPosition
position: 102
reference: MNRAAIAAGKPSGSISTGKPRRKTRAEVSEEMKHEIREAFDLFDADRSGRIDFHELKVAMRALGFDVKKEEIQRIMNEYDRDQLGEITFQDFEEVMIEKISNRDPTEEILKAFRLFDDDATGRISLKNLRRVAKELSENISDEELLAMIQEFDRDGDGEIDEEDFIAILRSTSAFS

SIP26C822D849FCF281
type: Domain Extent Annotation
comment: EF-hand 3
range: 22854672993039918tt104tt139

22854672993039918tt104
type: Position
type: ExactPosition
position: 104
reference: MNRAAIAAGKPSGSISTGKPRRKTRAEVSEEMKHEIREAFDLFDADRSGRIDFHELKVAMRALGFDVKKEEIQRIMNEYDRDQLGEITFQDFEEVMIEKISNRDPTEEILKAFRLFDDDATGRISLKNLRRVAKELSENISDEELLAMIQEFDRDGDGEIDEEDFIAILRSTSAFS

22854672993039918tt139
type: Position
type: ExactPosition
position: 139
reference: MNRAAIAAGKPSGSISTGKPRRKTRAEVSEEMKHEIREAFDLFDADRSGRIDFHELKVAMRALGFDVKKEEIQRIMNEYDRDQLGEITFQDFEEVMIEKISNRDPTEEILKAFRLFDDDATGRISLKNLRRVAKELSENISDEELLAMIQEFDRDGDGEIDEEDFIAILRSTSAFS

SIP63B7F6661F040A44
type: Domain Extent Annotation
comment: EF-hand 4
range: 22854672993039918tt140tt175

22854672993039918tt140
type: Position
type: ExactPosition
position: 140
reference: MNRAAIAAGKPSGSISTGKPRRKTRAEVSEEMKHEIREAFDLFDADRSGRIDFHELKVAMRALGFDVKKEEIQRIMNEYDRDQLGEITFQDFEEVMIEKISNRDPTEEILKAFRLFDDDATGRISLKNLRRVAKELSENISDEELLAMIQEFDRDGDGEIDEEDFIAILRSTSAFS

22854672993039918tt175
type: Position
type: ExactPosition
position: 175
reference: MNRAAIAAGKPSGSISTGKPRRKTRAEVSEEMKHEIREAFDLFDADRSGRIDFHELKVAMRALGFDVKKEEIQRIMNEYDRDQLGEITFQDFEEVMIEKISNRDPTEEILKAFRLFDDDATGRISLKNLRRVAKELSENISDEELLAMIQEFDRDGDGEIDEEDFIAILRSTSAFS

SIP2730A0DBCF818CDA
type: Region Annotation
comment: Disordered
range: 22854672993039918tt1tt27

22854672993039918tt27
type: Position
type: ExactPosition
position: 27
reference: MNRAAIAAGKPSGSISTGKPRRKTRAEVSEEMKHEIREAFDLFDADRSGRIDFHELKVAMRALGFDVKKEEIQRIMNEYDRDQLGEITFQDFEEVMIEKISNRDPTEEILKAFRLFDDDATGRISLKNLRRVAKELSENISDEELLAMIQEFDRDGDGEIDEEDFIAILRSTSAFS

22854672993039918tt44
type: Position
type: ExactPosition
position: 44
reference: MNRAAIAAGKPSGSISTGKPRRKTRAEVSEEMKHEIREAFDLFDADRSGRIDFHELKVAMRALGFDVKKEEIQRIMNEYDRDQLGEITFQDFEEVMIEKISNRDPTEEILKAFRLFDDDATGRISLKNLRRVAKELSENISDEELLAMIQEFDRDGDGEIDEEDFIAILRSTSAFS

22854672993039918tt46
type: Position
type: ExactPosition
position: 46
reference: MNRAAIAAGKPSGSISTGKPRRKTRAEVSEEMKHEIREAFDLFDADRSGRIDFHELKVAMRALGFDVKKEEIQRIMNEYDRDQLGEITFQDFEEVMIEKISNRDPTEEILKAFRLFDDDATGRISLKNLRRVAKELSENISDEELLAMIQEFDRDGDGEIDEEDFIAILRSTSAFS

22854672993039918tt48
type: Position
type: ExactPosition
position: 48
reference: MNRAAIAAGKPSGSISTGKPRRKTRAEVSEEMKHEIREAFDLFDADRSGRIDFHELKVAMRALGFDVKKEEIQRIMNEYDRDQLGEITFQDFEEVMIEKISNRDPTEEILKAFRLFDDDATGRISLKNLRRVAKELSENISDEELLAMIQEFDRDGDGEIDEEDFIAILRSTSAFS

22854672993039918tt50
type: Position
type: ExactPosition
position: 50
reference: MNRAAIAAGKPSGSISTGKPRRKTRAEVSEEMKHEIREAFDLFDADRSGRIDFHELKVAMRALGFDVKKEEIQRIMNEYDRDQLGEITFQDFEEVMIEKISNRDPTEEILKAFRLFDDDATGRISLKNLRRVAKELSENISDEELLAMIQEFDRDGDGEIDEEDFIAILRSTSAFS

22854672993039918tt55
type: Position
type: ExactPosition
position: 55
reference: MNRAAIAAGKPSGSISTGKPRRKTRAEVSEEMKHEIREAFDLFDADRSGRIDFHELKVAMRALGFDVKKEEIQRIMNEYDRDQLGEITFQDFEEVMIEKISNRDPTEEILKAFRLFDDDATGRISLKNLRRVAKELSENISDEELLAMIQEFDRDGDGEIDEEDFIAILRSTSAFS

22854672993039918tt153
type: Position
type: ExactPosition
position: 153
reference: MNRAAIAAGKPSGSISTGKPRRKTRAEVSEEMKHEIREAFDLFDADRSGRIDFHELKVAMRALGFDVKKEEIQRIMNEYDRDQLGEITFQDFEEVMIEKISNRDPTEEILKAFRLFDDDATGRISLKNLRRVAKELSENISDEELLAMIQEFDRDGDGEIDEEDFIAILRSTSAFS

22854672993039918tt155
type: Position
type: ExactPosition
position: 155
reference: MNRAAIAAGKPSGSISTGKPRRKTRAEVSEEMKHEIREAFDLFDADRSGRIDFHELKVAMRALGFDVKKEEIQRIMNEYDRDQLGEITFQDFEEVMIEKISNRDPTEEILKAFRLFDDDATGRISLKNLRRVAKELSENISDEELLAMIQEFDRDGDGEIDEEDFIAILRSTSAFS

22854672993039918tt157
type: Position
type: ExactPosition
position: 157
reference: MNRAAIAAGKPSGSISTGKPRRKTRAEVSEEMKHEIREAFDLFDADRSGRIDFHELKVAMRALGFDVKKEEIQRIMNEYDRDQLGEITFQDFEEVMIEKISNRDPTEEILKAFRLFDDDATGRISLKNLRRVAKELSENISDEELLAMIQEFDRDGDGEIDEEDFIAILRSTSAFS

22854672993039918tt159
type: Position
type: ExactPosition
position: 159
reference: MNRAAIAAGKPSGSISTGKPRRKTRAEVSEEMKHEIREAFDLFDADRSGRIDFHELKVAMRALGFDVKKEEIQRIMNEYDRDQLGEITFQDFEEVMIEKISNRDPTEEILKAFRLFDDDATGRISLKNLRRVAKELSENISDEELLAMIQEFDRDGDGEIDEEDFIAILRSTSAFS

22854672993039918tt164
type: Position
type: ExactPosition
position: 164
reference: MNRAAIAAGKPSGSISTGKPRRKTRAEVSEEMKHEIREAFDLFDADRSGRIDFHELKVAMRALGFDVKKEEIQRIMNEYDRDQLGEITFQDFEEVMIEKISNRDPTEEILKAFRLFDDDATGRISLKNLRRVAKELSENISDEELLAMIQEFDRDGDGEIDEEDFIAILRSTSAFS

1
subclass of: CHEBI_29108

2
subclass of: CHEBI_29108

MNRAAIAAGKPSGSISTGKPRRKTRAEVSEEMKHEIREAFDLFDADRSGRIDFHELKVAMRALGFDVKKEEIQRIMNEYDRDQLGEITFQDFEEVMIEKISNRDPTEEILKAFRLFDDDATGRISLKNLRRVAKELSENISDEELLAMIQEFDRDGDGEIDEEDFIAILRSTSAFS
type: Simple Sequence
modified: 1997-11-01
version: 1
mass: 20238

http://purl.uniprot.org/uniprot/Q24956#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/Q24956#attribution-25A091502DB1203023DC7E3B797564C8
manual: true
evidence: ECO_0000255
source: PRU00448

http://purl.uniprot.org/uniprot/Q24956#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

O97438
type: Protein
reviewed: true
created: 2003-04-23
modified: 2023-09-13
version: 86
mnemonic: CBK_GIAIN
old mnemonic: CBK_GIALA
citation: http://purl.uniprot.org/citations/10029308
recommended name: SIPDFCC33931EFF16E4
enzyme: http://purl.uniprot.org/enzyme/2.7.2.2
organism: http://purl.uniprot.org/taxonomy/5741
annotation: SIP678743F604D3A332
annotation: SIPB2B1D86D04B201BE
annotation: SIPBBA46FA5035DBDEA
annotation: SIP2EE68893EB017807
annotation: PRO_0000185152
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/56
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/418
classified with: GO_0005524
classified with: GO_0008804
classified with: GO_0006525
classified with: GO_0035975
classified with: GO_0016310
sequence: O97438-1

O97438-citation-10029308
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: IDENTIFICATION BY MASS SPECTROMETRY
scope: CHARACTERIZATION

Portland-1
type: Strain

ENOG502S00U
type: Resource
database: eggNOG
comment: Eukaryota

http://purl.uniprot.org/brenda/2.7.2.2
type: Resource
database: BRENDA
comment: 2401
comment: 6459

cd04235
type: Resource
database: CDD
comment: AAK_CK
signature sequence match: CDD cd04235 match 1

http://purl.uniprot.org/gene3d/3.40.1160.10
type: Resource
database: Gene3D
comment: Acetylglutamate kinase-like
signature sequence match: Gene3D 3.40.1160.10 match 1

IPR036393
type: Resource
database: InterPro
comment: AceGlu_kinase-like_sf

IPR001048
type: Resource
database: InterPro
comment: Asp/Glu/Uridylate_kinase

IPR003964
type: Resource
database: InterPro
comment: Carb_kinase

TIGR00746
type: Resource
database: NCBIfam
comment: arcC
signature sequence match: NCBIfam TIGR00746 match 1

PTHR30409
type: Resource
database: PANTHER
comment: CARBAMATE KINASE
signature sequence match: PANTHER PTHR30409 match 1

PTHR30409:SF1
type: Resource
database: PANTHER
comment: CARBAMATE KINASE-RELATED
signature sequence match: PANTHER PTHR30409:SF1 match 1

PF00696
type: Resource
database: Pfam
comment: AA_kinase
signature sequence match: Pfam PF00696 match 1

PIRSF000723
type: Resource
database: PIRSF
comment: Carbamate_kin
signature sequence match: PIRSF PIRSF000723 match 1

PR01469
type: Resource
database: PRINTS
comment: CARBMTKINASE

SSF53633
type: Resource
database: SUPFAM
comment: Carbamate kinase-like
signature sequence match: SUPFAM SSF53633 match 1

SIPDFCC33931EFF16E4
type: Structured Name
full name: Carbamate kinase
ec name: 2.7.2.2

CBK
type: Gene

SIPBBA46FA5035DBDEA
type: Subunit Annotation
comment: Homodimer.

SIP2EE68893EB017807
type: Similarity Annotation
comment: Belongs to the carbamate kinase family.

PRO_0000185152
type: Chain Annotation
comment: Carbamate kinase
mass: 34221
range: 22299432421898286tt1tt317

22299432421898286tt1
type: Position
type: ExactPosition
position: 1
reference: O97438-1

22299432421898286tt317
type: Position
type: ExactPosition
position: 317
reference: O97438-1

O97438-1
type: Simple Sequence
modified: 1999-05-01
version: 1
mass: 34221
value: MSAGKTVVIALGGNAMLQAKEKGDYDTQRKNVEIAASEIYKIHKAGYKVVLTSGNAPQVGAIKLQNQAAAGVSPEMPLHVCGAMSQGFIGYMMSQAMDNVFCANNEPANCVTCVTQTLVDPKDQAFTNPTKPRWRFYTEQEAKDLMAANPGKILREDAWPAGWRVVVPSPRPLEIVEYGVIKTLIDNNVLVICTNGGGIPCKRENKVISGVDAVIDKDLATSLLAKTLNSDYLMILTDVLNACINYKKPDERKLEEIKLSEILALEKDGHFAAGSMGPKVRAAIEFTQATGKMSIITSLSTAVDALNGKCGTRIIKD

http://purl.uniprot.org/uniprot/O97438#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

O96432
type: Protein
reviewed: true
created: 2003-04-23
modified: 2023-09-13
version: 87
mnemonic: CBK_TRIVA
citation: http://purl.uniprot.org/citations/10864518
recommended name: SIPDFCC33931EFF16E4
enzyme: http://purl.uniprot.org/enzyme/2.7.2.2
organism: http://purl.uniprot.org/taxonomy/5722
annotation: SIP87607D3DDC8664F2
annotation: SIP685898D74C65BEDD
annotation: SIP181C11257274BEAC
annotation: SIPDED23CC6A67DA23A
annotation: PRO_0000185153
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/56
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/418
classified with: GO_0005524
classified with: GO_0008804
classified with: GO_0006525
classified with: GO_0035975
classified with: GO_0016310
sequence: O96432-1

O96432-citation-10864518
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: IDENTIFICATION BY MASS SPECTROMETRY
scope: CHARACTERIZATION

WAA38
type: Strain

SIPDFCC33931EFF16E4
type: Structured Name
full name: Carbamate kinase
ec name: 2.7.2.2

CBK
type: Gene

SIP181C11257274BEAC
type: Subunit Annotation
comment: Homodimer.

SIPDED23CC6A67DA23A
type: Similarity Annotation
comment: Belongs to the carbamate kinase family.

PRO_0000185153
type: Chain Annotation
comment: Carbamate kinase
mass: 33927
range: 22299428126929454tt1tt314

22299428126929454tt1
type: Position
type: ExactPosition
position: 1
reference: O96432-1

22299428126929454tt314
type: Position
type: ExactPosition
position: 314
reference: O96432-1

O96432-1
type: Simple Sequence
modified: 1999-05-01
version: 1
mass: 33927
value: MRIVVALGGNALLQRGMKGTFQDQQAACRLAMSQIVKIVKDGNELVMTHGNGPQCGAIFLQNVAGEQEKVPAMPLHVCGAETQGFLGELLQQELDGALRAEGIKKNVVSIVTQSFVDPKDPAFQNPTKPIGPFYSKEEAEFLRNERGYNMVEDAGRGYRMIVPSPVPQKFVEKEAIKTLVNSGFIVVCSGGGGIPVILDEQENRIEGVDAVIDKDLGASVLAAATNADAFMILTDVPEALLNYRKENETAIRQATVAEMEKYIEEGHFIKGSMLPKVQACLRFVKSTGKPALITALDCALQALKGERGTKIVPN

http://purl.uniprot.org/uniprot/O96432#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

Q95058
type: Protein
reviewed: true
created: 1998-07-15
modified: 2023-09-13
version: 88
mnemonic: CH60_TRIVA
citation: http://purl.uniprot.org/citations/8790385
recommended name: SIPE5C2E6F7D1C336DE
alternative name: SIPEA7AEA5FD020032D
alternative name: SIPFBE1A3C9029B3403
organism: http://purl.uniprot.org/taxonomy/5722
annotation: SIPB8BC2CEA94F99B0E
annotation: SIP0C01CCDA13662814
annotation: SIP798DB8C69927A022
annotation: PRO_0000063638
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/143
classified with: http://purl.uniprot.org/keywords/377
classified with: GO_0042566
classified with: GO_0005524
classified with: GO_0140662
classified with: GO_0042026
sequence: Q95058-1

Q95058-citation-8790385
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

KOG0356
type: Resource
database: eggNOG
comment: Eukaryota

cd03344
type: Resource
database: CDD
comment: GroEL
signature sequence match: CDD cd03344 match 1

http://purl.uniprot.org/gene3d/3.50.7.10
type: Resource
database: Gene3D
comment: GroEL
signature sequence match: Gene3D 3.50.7.10 match 1

http://purl.uniprot.org/gene3d/1.10.560.10
type: Resource
database: Gene3D
comment: GroEL-like equatorial domain
signature sequence match: Gene3D 1.10.560.10 match 1

http://purl.uniprot.org/gene3d/3.30.260.10
type: Resource
database: Gene3D
comment: TCP-1-like chaperonin intermediate domain
signature sequence match: Gene3D 3.30.260.10 match 1

IPR018370
type: Resource
database: InterPro
comment: Chaperonin_Cpn60_CS

IPR001844
type: Resource
database: InterPro
comment: Cpn60/GroEL

IPR002423
type: Resource
database: InterPro
comment: Cpn60/GroEL/TCP-1

IPR027409
type: Resource
database: InterPro
comment: GroEL-like_apical_dom_sf

IPR027413
type: Resource
database: InterPro
comment: GROEL-like_equatorial_sf

IPR027410
type: Resource
database: InterPro
comment: TCP-1-like_intermed_sf

TIGR02348
type: Resource
database: NCBIfam
comment: GroEL
signature sequence match: NCBIfam TIGR02348 match 1

PTHR45633
type: Resource
database: PANTHER
comment: 60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL
signature sequence match: PANTHER PTHR45633 match 1

PTHR45633:SF3
type: Resource
database: PANTHER
comment: 60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL
signature sequence match: PANTHER PTHR45633:SF3 match 1

PF00118
type: Resource
database: Pfam
comment: Cpn60_TCP1
signature sequence match: Pfam PF00118 match 1

PR00298
type: Resource
database: PRINTS
comment: CHAPERONIN60

SSF52029
type: Resource
database: SUPFAM
comment: GroEL apical domain-like
signature sequence match: SUPFAM SSF52029 match 1

SSF48592
type: Resource
database: SUPFAM
comment: GroEL equatorial domain-like
signature sequence match: SUPFAM SSF48592 match 1

SSF54849
type: Resource
database: SUPFAM
comment: GroEL-intermediate domain like
signature sequence match: SUPFAM SSF54849 match 1

PS00296
type: Resource
database: PROSITE
comment: CHAPERONINS_CPN60
signature sequence match: PROSITE PS00296 match 1

SIPE5C2E6F7D1C336DE
type: Structured Name
full name: Hydrogenosomal chaperonin HSP60
short name: Protein Cpn60

SIPEA7AEA5FD020032D
type: Structured Name
full name: Heat shock protein 60

SIPFBE1A3C9029B3403
type: Structured Name
full name: groEL protein

HSP60
type: Gene

SIPB8BC2CEA94F99B0E
type: Function Annotation
comment: Implicated in hydrogenosomal protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the hydrogenosome (Potential).

SIP798DB8C69927A022
type: Similarity Annotation
comment: Belongs to the chaperonin (HSP60) family.

PRO_0000063638
type: Chain Annotation
comment: Hydrogenosomal chaperonin HSP60
mass: 50614
range: 22862373718407214tt1tt470

22862373718407214tt1
type: Position
type: ExactPosition
position: 1
reference: Q95058-1

22862373718407214tt470
type: Position
type: ExactPosition
position: 470
reference: Q95058-1

Q95058-1
type: Simple Sequence
modified: 1997-02-01
version: 1
mass: 50614
value: MSLIEAAKHFTRAFAKARDLKFGSDARDHLLLGVEKLADAVVSTLGPKGRNVMIELPYGPPKVTKDGVTVAKSIEFKDKWQNLGAQLVINVAQKTNDVAGDGTTTATLLTRELYRESIKALSAGLDPNKVRKGMTLRVDAVVKELEKSTKKVSSPDEIFNVATISANGSEKIGHLIADAFKAVGNEGVITVAMGKKFDHELETVQGMKIDRGYISSYFQNDTKSMKCEYENPYILITDIKINSFAQIAPILEKIITTGRPLLIIADDVEGDALATLIVNKIRGSLKVVAIRAPGFGDNKKNTLQDIAVATGGQYISEELGLKLEEATQQMLGQCNKITVSKDDCIILGGAGDKDAMKARSEDIKKQLSNTQSKYETDKLRERLAKLTGGVAVISVGGANEVEVGEEKDLIDDALNATRAAIEEGIVAGGGTALLRASAVLEPLKKDKGLEERTGIEIIQNSHQTASHSHC

http://purl.uniprot.org/uniprot/Q95058#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

P33403
type: Protein
reviewed: true
created: 1994-02-01
modified: 2022-12-14
version: 66
mnemonic: CYSP_TRIFO
citation: http://purl.uniprot.org/citations/8319888
recommended name: SIP14CA8C1984656D5F
enzyme: http://purl.uniprot.org/enzyme/3.4.22.-
organism: http://purl.uniprot.org/taxonomy/56690
annotation: SIP9AC744018EE11546
annotation: PRO_0000050545
annotation: SIP40E9227B4416D0AA
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/788
classified with: GO_0008234
classified with: GO_0006508
sequence: ADSLDWREKGVVNSIKDQAQXGS

P33403-citation-8319888
type: Citation Statement
scope: PROTEIN SEQUENCE

SIP14CA8C1984656D5F
type: Structured Name
full name: Cysteine proteinase
ec name: 3.4.22.-

SIP9AC744018EE11546
type: Similarity Annotation
comment: Belongs to the peptidase C1 family.

PRO_0000050545
type: Chain Annotation
comment: Cysteine proteinase
mass: 2515
range: 22574293148775214tt1tf23

22574293148775214tt1
type: Position
type: ExactPosition
position: 1
reference: ADSLDWREKGVVNSIKDQAQXGS

22574293148775214tt23
type: Position
type: ExactPosition
position: 23
reference: ADSLDWREKGVVNSIKDQAQXGS

ADSLDWREKGVVNSIKDQAQXGS
type: Simple Sequence
modified: 1994-02-01
version: 1
fragment: single
mass: 2515

http://purl.uniprot.org/uniprot/P33403#attribution-28428EF056A8E20E0D4A5A73CDC590CB
manual: true
evidence: ECO_0000255
source: PRU10088

http://purl.uniprot.org/uniprot/P33403#attribution-4EE29B77D2645F25A6F24BE62783D881
manual: true
evidence: ECO_0000255
source: PRU10089

http://purl.uniprot.org/uniprot/P33403#attribution-F99589090D3A9D37BF3B4263A0E69596
manual: true
evidence: ECO_0000255
source: PRU10090

P33404
type: Protein
reviewed: true
created: 1994-02-01
modified: 2022-08-03
version: 55
mnemonic: CYSP_TRIVA
citation: http://purl.uniprot.org/citations/8319888
recommended name: SIP14CA8C1984656D5F
enzyme: http://purl.uniprot.org/enzyme/3.4.22.-
organism: http://purl.uniprot.org/taxonomy/5722
annotation: SIPD884145AFD07A6B6
annotation: PRO_0000050546
annotation: SIP5CE7AAEC201733E8
annotation: SIPE8E8A822AC06BD99
annotation: SIP6601D87469AD42CA
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/788
classified with: GO_0008234
classified with: GO_0006508
sequence: GADDSDWRKKGAVNVIXKDQGQ

P33404-citation-8319888
type: Citation Statement
scope: PROTEIN SEQUENCE

SIP14CA8C1984656D5F
type: Structured Name
full name: Cysteine proteinase
ec name: 3.4.22.-

SIPD884145AFD07A6B6
type: Similarity Annotation
comment: Belongs to the peptidase C1 family.

PRO_0000050546
type: Chain Annotation
comment: Cysteine proteinase
mass: 2399
range: 22574293148775470tt1tf22

22574293148775470tt1
type: Position
type: ExactPosition
position: 1
reference: GADDSDWRKKGAVNVIXKDQGQ

22574293148775470tt22
type: Position
type: ExactPosition
position: 22
reference: GADDSDWRKKGAVNVIXKDQGQ

SIP5CE7AAEC201733E8
type: Region Annotation
comment: Disordered
range: 22574293148775470tt1tt22

SIPE8E8A822AC06BD99
type: Sequence Uncertainty Annotation
comment: G or K
range: 22574293148775470tt1tt1

GADDSDWRKKGAVNVIXKDQGQ
type: Simple Sequence
modified: 1994-02-01
version: 1
fragment: single
mass: 2399

http://purl.uniprot.org/uniprot/P33404#attribution-28428EF056A8E20E0D4A5A73CDC590CB
manual: true
evidence: ECO_0000255
source: PRU10088

http://purl.uniprot.org/uniprot/P33404#attribution-4EE29B77D2645F25A6F24BE62783D881
manual: true
evidence: ECO_0000255
source: PRU10089

http://purl.uniprot.org/uniprot/P33404#attribution-F99589090D3A9D37BF3B4263A0E69596
manual: true
evidence: ECO_0000255
source: PRU10090

A8BQJ3
type: Protein
reviewed: true
created: 2009-05-05
modified: 2023-06-28
version: 69
mnemonic: DCL_GIAIC
old mnemonic: DCL_GIALA
replaces: Q86QW6
citation: http://purl.uniprot.org/citations/17901334
citation: http://purl.uniprot.org/citations/16410517
citation: http://purl.uniprot.org/citations/17704568
recommended name: SIP80A70E29D824E8C7
enzyme: http://purl.uniprot.org/enzyme/3.1.26.-
organism: http://purl.uniprot.org/taxonomy/184922
annotation: SIP04BD354C88563734
annotation: SIP1CF48F1A918CB4C1
annotation: SIPD128E0D13BBD58E6
annotation: PRO_0000371303
annotation: SIPA6D1457A77BF805D
annotation: SIP4CAA35A323541302
annotation: SIP1DF8D0412D6ED85F
annotation: SIP1AF1BD81023FABE4
annotation: SIP97D63600146607AF
annotation: SIP427BDEB1855FDAB4
annotation: SIP32BCC654C9AAF039
annotation: SIPFFBBD36892E62C67
annotation: SIP6A8B8D71EC126AD8
annotation: SIP00F927822D6ADD9F
annotation: SIP8A2CC2D985ADB947
annotation: SIP17DDCC205261C603
annotation: SIP5F81072BD1FD3511
annotation: SIP2DE1E584B1CA066E
annotation: SIPAA6DED6D25940755
annotation: SIPF7482FB44EFFB1F9
annotation: SIP96E7E0AD7FCEAE33
annotation: SIP8166239BC9E4627B
annotation: SIP8A0F9B7B73AB6DD2
annotation: SIPDB06A494BA28D455
annotation: SIP734509F65CF04D36
annotation: SIPF6E271AA2C2CDAD4
annotation: SIPBFF48BE0196020CE
annotation: SIP6D403A1FA42CC12A
annotation: SIP0E8711AACA849110
annotation: SIP80C086780635EF58
annotation: SIPF53AAC7893C2E00A
annotation: SIP7932335C861D994C
annotation: SIP8B7A03CD60386539
annotation: SIP383B3AD23F5B1E46
annotation: SIP13E28308D001D048
annotation: SIPE3C5111FBBB8C710
annotation: SIP425760D9E7EC00BA
annotation: SIP4AD86D372D7637D7
annotation: SIP46F454D8DFB9974A
annotation: SIPA4C9F776F23395DF
annotation: SIP30F0068EC933A4BE
annotation: SIP29AF08253FC170B1
annotation: SIP2C778685D976A041
annotation: SIP1818DAFFB436600C
annotation: SIP0B8C85AAE51DBF96
annotation: SIPA49781505F449FEC
annotation: SIP7D45CFAC7AA6B902
annotation: SIP79599B6FB5F521BF
annotation: SIP2E95FF9C376610E9
annotation: SIP68AC0C2CCB25FFAD
annotation: SIP807151F121B708A0
annotation: SIP2CD304058BF1B040
annotation: SIPA72620A8D16C730E
annotation: SIP899D3F07257405E5
annotation: SIP5BD4D5813EFE0EEB
annotation: SIP1198151831E85A69
annotation: SIP159865200E5DDBC7
annotation: SIPCB10EE4B7EBB5600
annotation: SIP34175B039B15D2C2
annotation: SIPE97E5E2CA7C3AF9D
annotation: SIP6FE21FB1DC3CB2BA
annotation: SIP4911DB2DFFA68F0A
annotation: SIP4F9D8667BB143448
annotation: SIPBD4E594BAD4D0141
annotation: SIP27E1F0725AA25211
annotation: SIP7D8F913F56FC4DA3

A8BQJ3-citation-17901334
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 50803 / WB clone C6
type: Strain

A8BQJ3-citation-16410517
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (3.33 ANGSTROMS) IN COMPLEX WITH MANGANESE
scope: FUNCTION
scope: CATALYTIC ACTIVITY
scope: COFACTOR
scope: SUBUNIT

A8BQJ3-citation-17704568
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) IN COMPLEX WITH MANGANESE
scope: SUBUNIT
scope: COFACTOR

2FFL
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 3.33
chain sequence mapping: PDB 2FFL tt1tt754

PDB 2FFL tt1tt754
chain: A/B/C/D=1-754

2QVW
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 3.00
chain sequence mapping: PDB 2QVW tt1tt754

PDB 2QVW tt1tt754
chain: A/B/C/D=1-754

http://purl.uniprot.org/brenda/3.1.26.3
type: Resource
database: BRENDA
comment: 2401

cd00593
type: Resource
database: CDD
comment: RIBOc
signature sequence match: CDD cd00593 match 1
signature sequence match: CDD cd00593 match 2

http://purl.uniprot.org/gene3d/1.10.1520.10
type: Resource
database: Gene3D
comment: Ribonuclease III domain
signature sequence match: Gene3D 1.10.1520.10 match 1
signature sequence match: Gene3D 1.10.1520.10 match 2

IPR041279
type: Resource
database: InterPro
comment: Dicer_N

IPR003100
type: Resource
database: InterPro
comment: PAZ_dom

IPR036085
type: Resource
database: InterPro
comment: PAZ_dom_sf

IPR000999
type: Resource
database: InterPro
comment: RNase_III_dom

IPR036389
type: Resource
database: InterPro
comment: RNase_III_sf

PTHR14950
type: Resource
database: PANTHER
comment: DICER-RELATED
signature sequence match: PANTHER PTHR14950 match 1

PTHR14950:SF37
type: Resource
database: PANTHER
comment: ENDORIBONUCLEASE DICER
signature sequence match: PANTHER PTHR14950:SF37 match 1

PF17895
type: Resource
database: Pfam
comment: Dicer_N
signature sequence match: Pfam PF17895 match 1

PF02170
type: Resource
database: Pfam
comment: PAZ
signature sequence match: Pfam PF02170 match 1

PF00636
type: Resource
database: Pfam
comment: Ribonuclease_3
signature sequence match: Pfam PF00636 match 1
signature sequence match: Pfam PF00636 match 2

SM00949
type: Resource
database: SMART
comment: PAZ
signature sequence match: SMART SM00949 match 1

SM00535
type: Resource
database: SMART
comment: RIBOc
signature sequence match: SMART SM00535 match 1
signature sequence match: SMART SM00535 match 2

SSF101690
type: Resource
database: SUPFAM
comment: PAZ domain
signature sequence match: SUPFAM SSF101690 match 1

SSF69065
type: Resource
database: SUPFAM
comment: RNase III domain-like
signature sequence match: SUPFAM SSF69065 match 1
signature sequence match: SUPFAM SSF69065 match 2

PS50142
type: Resource
database: PROSITE
comment: RNASE_3_2
signature sequence match: PROSITE PS50142 match 1
signature sequence match: PROSITE PS50142 match 2

SIP80A70E29D824E8C7
type: Structured Name
full name: Endoribonuclease Dicer-like
ec name: 3.1.26.-

http://purl.uniprot.org/uniprot/A8BQJ3#gene-MD5C59A2C84964A30F2EAAAF2819F1BF6C4
type: Gene
orf name: GL50803_103887

SIP04BD354C88563734
type: Function Annotation
comment: Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs.

SIP1CF48F1A918CB4C1
type: Cofactor Annotation
comment: Binds 2 magnesium or manganese ions per subunit.
cofactor: CHEBI_18420
cofactor: CHEBI_29035

SIPD128E0D13BBD58E6
type: Subunit Annotation
comment: Homodimer.

PRO_0000371303
type: Chain Annotation
comment: Endoribonuclease Dicer-like
mass: 82478
range: 18357730969006894tt1tt754

18357730969006894tt1
type: Position
type: ExactPosition
position: 1
reference: A8BQJ3-1

18357730969006894tt754
type: Position
type: ExactPosition
position: 754
reference: A8BQJ3-1

SIPA6D1457A77BF805D
type: Domain Extent Annotation
comment: PAZ
range: 18357730969006894tt132tt251

18357730969006894tt132
type: Position
type: ExactPosition
position: 132
reference: A8BQJ3-1

18357730969006894tt251
type: Position
type: ExactPosition
position: 251
reference: A8BQJ3-1

SIP4CAA35A323541302
type: Domain Extent Annotation
comment: RNase III 1
range: 18357730969006894tt298tt418

18357730969006894tt298
type: Position
type: ExactPosition
position: 298
reference: A8BQJ3-1

18357730969006894tt418
type: Position
type: ExactPosition
position: 418
reference: A8BQJ3-1

SIP1DF8D0412D6ED85F
type: Domain Extent Annotation
comment: RNase III 2
range: 18357730969006894tt613tt734

18357730969006894tt613
type: Position
type: ExactPosition
position: 613
reference: A8BQJ3-1

18357730969006894tt734
type: Position
type: ExactPosition
position: 734
reference: A8BQJ3-1

18357730969006894tt336
type: Position
type: ExactPosition
position: 336
reference: A8BQJ3-1

18357730969006894tt404
type: Position
type: ExactPosition
position: 404
reference: A8BQJ3-1

18357730969006894tt407
type: Position
type: ExactPosition
position: 407
reference: A8BQJ3-1

18357730969006894tt649
type: Position
type: ExactPosition
position: 649
reference: A8BQJ3-1

18357730969006894tt720
type: Position
type: ExactPosition
position: 720
reference: A8BQJ3-1

18357730969006894tt723
type: Position
type: ExactPosition
position: 723
reference: A8BQJ3-1

18357730969006894tt4
type: Position
type: ExactPosition
position: 4
reference: A8BQJ3-1

18357730969006894tt11
type: Position
type: ExactPosition
position: 11
reference: A8BQJ3-1

18357730969006894tt16
type: Position
type: ExactPosition
position: 16
reference: A8BQJ3-1

18357730969006894tt25
type: Position
type: ExactPosition
position: 25
reference: A8BQJ3-1

18357730969006894tt33
type: Position
type: ExactPosition
position: 33
reference: A8BQJ3-1

18357730969006894tt35
type: Position
type: ExactPosition
position: 35
reference: A8BQJ3-1

18357730969006894tt39
type: Position
type: ExactPosition
position: 39
reference: A8BQJ3-1

18357730969006894tt41
type: Position
type: ExactPosition
position: 41
reference: A8BQJ3-1

18357730969006894tt44
type: Position
type: ExactPosition
position: 44
reference: A8BQJ3-1

18357730969006894tt47
type: Position
type: ExactPosition
position: 47
reference: A8BQJ3-1

18357730969006894tt58
type: Position
type: ExactPosition
position: 58
reference: A8BQJ3-1

18357730969006894tt75
type: Position
type: ExactPosition
position: 75
reference: A8BQJ3-1

18357730969006894tt83
type: Position
type: ExactPosition
position: 83
reference: A8BQJ3-1

18357730969006894tt88
type: Position
type: ExactPosition
position: 88
reference: A8BQJ3-1

18357730969006894tt92
type: Position
type: ExactPosition
position: 92
reference: A8BQJ3-1

18357730969006894tt94
type: Position
type: ExactPosition
position: 94
reference: A8BQJ3-1

18357730969006894tt95
type: Position
type: ExactPosition
position: 95
reference: A8BQJ3-1

18357730969006894tt97
type: Position
type: ExactPosition
position: 97
reference: A8BQJ3-1

18357730969006894tt110
type: Position
type: ExactPosition
position: 110
reference: A8BQJ3-1

18357730969006894tt117
type: Position
type: ExactPosition
position: 117
reference: A8BQJ3-1

18357730969006894tt125
type: Position
type: ExactPosition
position: 125
reference: A8BQJ3-1

18357730969006894tt135
type: Position
type: ExactPosition
position: 135
reference: A8BQJ3-1

18357730969006894tt140
type: Position
type: ExactPosition
position: 140
reference: A8BQJ3-1

18357730969006894tt142
type: Position
type: ExactPosition
position: 142
reference: A8BQJ3-1

18357730969006894tt144
type: Position
type: ExactPosition
position: 144
reference: A8BQJ3-1

18357730969006894tt146
type: Position
type: ExactPosition
position: 146
reference: A8BQJ3-1

18357730969006894tt151
type: Position
type: ExactPosition
position: 151
reference: A8BQJ3-1

18357730969006894tt153
type: Position
type: ExactPosition
position: 153
reference: A8BQJ3-1

18357730969006894tt158
type: Position
type: ExactPosition
position: 158
reference: A8BQJ3-1

18357730969006894tt160
type: Position
type: ExactPosition
position: 160
reference: A8BQJ3-1

18357730969006894tt162
type: Position
type: ExactPosition
position: 162
reference: A8BQJ3-1

18357730969006894tt166
type: Position
type: ExactPosition
position: 166
reference: A8BQJ3-1

18357730969006894tt168
type: Position
type: ExactPosition
position: 168
reference: A8BQJ3-1

18357730969006894tt179
type: Position
type: ExactPosition
position: 179
reference: A8BQJ3-1

18357730969006894tt182
type: Position
type: ExactPosition
position: 182
reference: A8BQJ3-1

18357730969006894tt186
type: Position
type: ExactPosition
position: 186
reference: A8BQJ3-1

18357730969006894tt189
type: Position
type: ExactPosition
position: 189
reference: A8BQJ3-1

18357730969006894tt192
type: Position
type: ExactPosition
position: 192
reference: A8BQJ3-1

18357730969006894tt193
type: Position
type: ExactPosition
position: 193
reference: A8BQJ3-1

18357730969006894tt199
type: Position
type: ExactPosition
position: 199
reference: A8BQJ3-1

18357730969006894tt210
type: Position
type: ExactPosition
position: 210
reference: A8BQJ3-1

18357730969006894tt217
type: Position
type: ExactPosition
position: 217
reference: A8BQJ3-1

18357730969006894tt218
type: Position
type: ExactPosition
position: 218
reference: A8BQJ3-1

18357730969006894tt223
type: Position
type: ExactPosition
position: 223
reference: A8BQJ3-1

18357730969006894tt240
type: Position
type: ExactPosition
position: 240
reference: A8BQJ3-1

18357730969006894tt242
type: Position
type: ExactPosition
position: 242
reference: A8BQJ3-1

18357730969006894tt244
type: Position
type: ExactPosition
position: 244
reference: A8BQJ3-1

18357730969006894tt246
type: Position
type: ExactPosition
position: 246
reference: A8BQJ3-1

18357730969006894tt258
type: Position
type: ExactPosition
position: 258
reference: A8BQJ3-1

18357730969006894tt262
type: Position
type: ExactPosition
position: 262
reference: A8BQJ3-1

18357730969006894tt265
type: Position
type: ExactPosition
position: 265
reference: A8BQJ3-1

18357730969006894tt282
type: Position
type: ExactPosition
position: 282
reference: A8BQJ3-1

18357730969006894tt283
type: Position
type: ExactPosition
position: 283
reference: A8BQJ3-1

18357730969006894tt285
type: Position
type: ExactPosition
position: 285
reference: A8BQJ3-1

18357730969006894tt293
type: Position
type: ExactPosition
position: 293
reference: A8BQJ3-1

18357730969006894tt304
type: Position
type: ExactPosition
position: 304
reference: A8BQJ3-1

18357730969006894tt313
type: Position
type: ExactPosition
position: 313
reference: A8BQJ3-1

18357730969006894tt315
type: Position
type: ExactPosition
position: 315
reference: A8BQJ3-1

18357730969006894tt318
type: Position
type: ExactPosition
position: 318
reference: A8BQJ3-1

18357730969006894tt320
type: Position
type: ExactPosition
position: 320
reference: A8BQJ3-1

18357730969006894tt323
type: Position
type: ExactPosition
position: 323
reference: A8BQJ3-1

18357730969006894tt325
type: Position
type: ExactPosition
position: 325
reference: A8BQJ3-1

18357730969006894tt328
type: Position
type: ExactPosition
position: 328
reference: A8BQJ3-1

18357730969006894tt354
type: Position
type: ExactPosition
position: 354
reference: A8BQJ3-1

18357730969006894tt360
type: Position
type: ExactPosition
position: 360
reference: A8BQJ3-1

18357730969006894tt371
type: Position
type: ExactPosition
position: 371
reference: A8BQJ3-1

18357730969006894tt373
type: Position
type: ExactPosition
position: 373
reference: A8BQJ3-1

18357730969006894tt382
type: Position
type: ExactPosition
position: 382
reference: A8BQJ3-1

18357730969006894tt386
type: Position
type: ExactPosition
position: 386
reference: A8BQJ3-1

18357730969006894tt388
type: Position
type: ExactPosition
position: 388
reference: A8BQJ3-1

18357730969006894tt402
type: Position
type: ExactPosition
position: 402
reference: A8BQJ3-1

18357730969006894tt415
type: Position
type: ExactPosition
position: 415
reference: A8BQJ3-1

18357730969006894tt419
type: Position
type: ExactPosition
position: 419
reference: A8BQJ3-1

18357730969006894tt431
type: Position
type: ExactPosition
position: 431
reference: A8BQJ3-1

18357730969006894tt434
type: Position
type: ExactPosition
position: 434
reference: A8BQJ3-1

18357730969006894tt436
type: Position
type: ExactPosition
position: 436
reference: A8BQJ3-1

18357730969006894tt446
type: Position
type: ExactPosition
position: 446
reference: A8BQJ3-1

18357730969006894tt456
type: Position
type: ExactPosition
position: 456
reference: A8BQJ3-1

18357730969006894tt462
type: Position
type: ExactPosition
position: 462
reference: A8BQJ3-1

18357730969006894tt471
type: Position
type: ExactPosition
position: 471
reference: A8BQJ3-1

18357730969006894tt472
type: Position
type: ExactPosition
position: 472
reference: A8BQJ3-1

18357730969006894tt476
type: Position
type: ExactPosition
position: 476
reference: A8BQJ3-1

18357730969006894tt480
type: Position
type: ExactPosition
position: 480
reference: A8BQJ3-1

18357730969006894tt483
type: Position
type: ExactPosition
position: 483
reference: A8BQJ3-1

18357730969006894tt484
type: Position
type: ExactPosition
position: 484
reference: A8BQJ3-1

18357730969006894tt495
type: Position
type: ExactPosition
position: 495
reference: A8BQJ3-1

18357730969006894tt498
type: Position
type: ExactPosition
position: 498
reference: A8BQJ3-1

18357730969006894tt514
type: Position
type: ExactPosition
position: 514
reference: A8BQJ3-1

18357730969006894tt526
type: Position
type: ExactPosition
position: 526
reference: A8BQJ3-1

18357730969006894tt540
type: Position
type: ExactPosition
position: 540
reference: A8BQJ3-1

18357730969006894tt543
type: Position
type: ExactPosition
position: 543
reference: A8BQJ3-1

18357730969006894tt545
type: Position
type: ExactPosition
position: 545
reference: A8BQJ3-1

18357730969006894tt560
type: Position
type: ExactPosition
position: 560
reference: A8BQJ3-1

18357730969006894tt562
type: Position
type: ExactPosition
position: 562
reference: A8BQJ3-1

18357730969006894tt565
type: Position
type: ExactPosition
position: 565
reference: A8BQJ3-1

18357730969006894tt568
type: Position
type: ExactPosition
position: 568
reference: A8BQJ3-1

18357730969006894tt569
type: Position
type: ExactPosition
position: 569
reference: A8BQJ3-1

18357730969006894tt571
type: Position
type: ExactPosition
position: 571
reference: A8BQJ3-1

18357730969006894tt574
type: Position
type: ExactPosition
position: 574
reference: A8BQJ3-1

18357730969006894tt576
type: Position
type: ExactPosition
position: 576
reference: A8BQJ3-1

18357730969006894tt586
type: Position
type: ExactPosition
position: 586
reference: A8BQJ3-1

18357730969006894tt588
type: Position
type: ExactPosition
position: 588
reference: A8BQJ3-1

18357730969006894tt589
type: Position
type: ExactPosition
position: 589
reference: A8BQJ3-1

18357730969006894tt600
type: Position
type: ExactPosition
position: 600
reference: A8BQJ3-1

18357730969006894tt609
type: Position
type: ExactPosition
position: 609
reference: A8BQJ3-1

18357730969006894tt618
type: Position
type: ExactPosition
position: 618
reference: A8BQJ3-1

18357730969006894tt629
type: Position
type: ExactPosition
position: 629
reference: A8BQJ3-1

18357730969006894tt640
type: Position
type: ExactPosition
position: 640
reference: A8BQJ3-1

18357730969006894tt643
type: Position
type: ExactPosition
position: 643
reference: A8BQJ3-1

18357730969006894tt645
type: Position
type: ExactPosition
position: 645
reference: A8BQJ3-1

18357730969006894tt646
type: Position
type: ExactPosition
position: 646
reference: A8BQJ3-1

18357730969006894tt667
type: Position
type: ExactPosition
position: 667
reference: A8BQJ3-1

18357730969006894tt673
type: Position
type: ExactPosition
position: 673
reference: A8BQJ3-1

18357730969006894tt682
type: Position
type: ExactPosition
position: 682
reference: A8BQJ3-1

18357730969006894tt686
type: Position
type: ExactPosition
position: 686
reference: A8BQJ3-1

18357730969006894tt694
type: Position
type: ExactPosition
position: 694
reference: A8BQJ3-1

18357730969006894tt699
type: Position
type: ExactPosition
position: 699
reference: A8BQJ3-1

18357730969006894tt707
type: Position
type: ExactPosition
position: 707
reference: A8BQJ3-1

18357730969006894tt708
type: Position
type: ExactPosition
position: 708
reference: A8BQJ3-1

18357730969006894tt710
type: Position
type: ExactPosition
position: 710
reference: A8BQJ3-1

18357730969006894tt716
type: Position
type: ExactPosition
position: 716
reference: A8BQJ3-1

18357730969006894tt733
type: Position
type: ExactPosition
position: 733
reference: A8BQJ3-1

18357730969006894tt735
type: Position
type: ExactPosition
position: 735
reference: A8BQJ3-1

18357730969006894tt745
type: Position
type: ExactPosition
position: 745
reference: A8BQJ3-1

18357730969006894tt747
type: Position
type: ExactPosition
position: 747
reference: A8BQJ3-1

18357730969006894tt749
type: Position
type: ExactPosition
position: 749
reference: A8BQJ3-1

1
subclass of: CHEBI_29035

2
subclass of: CHEBI_29035

A8BQJ3-1
type: Simple Sequence
modified: 2007-11-13
version: 1
mass: 82478
value: MHALGHCCTVVTTRGPSHWLLLLDTHLGTLPGFKVSAGRGLPAAEVYFEAGPRVSLSRTDATIVAVYQSILFQLLGPTFPASWTEIGATMPHNEYTFPRFISNPPQFATLAFLPLLSPTSPLDLRALMVTAQLMCDAKRLSDEYTDYSTLSASLHGRMVATPEISWSLYVVLGIDSTQTSLSYFTRANESITYMRYYATAHNIHLRAADLPLVAAVRLDDLKDHQIPAPGSWDDLAPKLRFLPPELCLLLPDEFDLIRVQALQFLPEIAKHICDIQNTICALDKSFPDCGRIGGERYFAITAGLRLDQGRGRGLAGWRTPFGPFGVSHTDVFQRLELLGDAVLGFIVTARLLCLFPDASVGTLVELKMELVRNEALNYLVQTLGLPQLAEFSNNLVAKSKTWADMYEEIVGSIFTGPNGIYGCEEFLAKTLMSPEHSKTVGSACPDAVTKASKRVCMGEAGAHEFRSLVDYACEQGISVFCSSRVSTMFLERLRDIPAEDMLDWYRLGIQFSHRSGLSGPGGVVSVIDIMTHLARGLWLGSPGFYVEQQTDKNESACPPTIPVLYIYHRSVQCPVLYGSLTETPTGPVASKVLALYEKILAYESSGGSKHIAAQTVSRSLAVPIPSGTIPFLIRLLQIALTPHVYQKLELLGDAFLKCSLALHLHALHPTLTEGALTRMRQSAETNSVLGRLTKRFPSVVSEVIIESHPKIQPDSKVYGDTFEAILAAILLACGEEAAGAFVREHVLPQVVADA

http://purl.uniprot.org/uniprot/A8BQJ3#attribution-09A40CD9DF3A0077F104F85851E2A9BD
manual: true
evidence: ECO_0000255
source: PRU00142

http://purl.uniprot.org/uniprot/A8BQJ3#attribution-9C029262D53B4176E52038D5A43847BA
manual: true
evidence: ECO_0000255
source: PRU00177

http://purl.uniprot.org/uniprot/A8BQJ3#attribution-27672FB42605E3524A3146997DCEC483
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/16410517

http://purl.uniprot.org/uniprot/A8BQJ3#attribution-7752A73CD2809AD0FCB253DDAD3400D5
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/17704568

http://purl.uniprot.org/uniprot/A8BQJ3#attribution-A7384DBB98E4C1931631DE4FD9DEA037
manual: true
evidence: ECO_0007744
source: 2FFL

http://purl.uniprot.org/uniprot/A8BQJ3#attribution-2C13A4917FDBB1501CA9A216738E82F0
manual: true
evidence: ECO_0007744
source: 2QVW

P28724
type: Protein
reviewed: true
created: 1992-12-01
modified: 2023-06-28
version: 92
mnemonic: DHE4_GIAIN
old mnemonic: DHE4_GIALA
replaces: Q24961
citation: http://purl.uniprot.org/citations/1559991
citation: http://purl.uniprot.org/citations/8587793
conflicting sequence: SIP5EB63BF1D48465E4
recommended name: SIP59B6866FF99DC8BD
alternative name: SIP7136725369D3F0AF
enzyme: http://purl.uniprot.org/enzyme/1.4.1.4
organism: http://purl.uniprot.org/taxonomy/5741
annotation: SIP025F91C15AD311D4
annotation: SIP7FCB4CA7CD7C8E0A
annotation: SIPDCA9EA810670AFED
annotation: PRO_0000182786
annotation: SIPDE8AAAC933D90F93
annotation: SIPE88A92D6811B0053
existence: Evidence at Transcript Level Existence
classified with: http://purl.uniprot.org/keywords/521
classified with: http://purl.uniprot.org/keywords/560
classified with: GO_0004354
classified with: GO_0006520
sequence: P28724-1

P28724-citation-1559991
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE

P28724-citation-8587793
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 59-261

KOG2250
type: Resource
database: eggNOG
comment: Eukaryota

http://purl.uniprot.org/brenda/1.4.1.4
type: Resource
database: BRENDA
comment: 2401

cd05313
type: Resource
database: CDD
comment: NAD_bind_2_Glu_DH
signature sequence match: CDD cd05313 match 1

http://purl.uniprot.org/gene3d/1.10.285.10
type: Resource
database: Gene3D
comment: Glutamate Dehydrogenase, chain A, domain 3
signature sequence match: Gene3D 1.10.285.10 match 1
signature sequence match: Gene3D 1.10.285.10 match 2

http://purl.uniprot.org/gene3d/3.40.50.10860
type: Resource
database: Gene3D
comment: Leucine Dehydrogenase, chain A, domain 1
signature sequence match: Gene3D 3.40.50.10860 match 1

http://purl.uniprot.org/gene3d/3.40.50.720
type: Resource
database: Gene3D
comment: NAD(P)-binding Rossmann-like Domain
signature sequence match: Gene3D 3.40.50.720 match 1

IPR046346
type: Resource
database: InterPro
comment: Aminoacid_DH-like_N_sf

IPR006095
type: Resource
database: InterPro
comment: Glu/Leu/Phe/Val/Trp_DH

IPR006096
type: Resource
database: InterPro
comment: Glu/Leu/Phe/Val/Trp_DH_C

IPR006097
type: Resource
database: InterPro
comment: Glu/Leu/Phe/Val/Trp_DH_dimer

IPR033524
type: Resource
database: InterPro
comment: Glu/Leu/Phe/Val_DH_AS

IPR014362
type: Resource
database: InterPro
comment: Glu_DH

IPR036291
type: Resource
database: InterPro
comment: NAD(P)-bd_dom_sf

IPR033922
type: Resource
database: InterPro
comment: NAD_bind_Glu_DH

PTHR43571
type: Resource
database: PANTHER
comment: NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED
signature sequence match: PANTHER PTHR43571 match 1

PTHR43571:SF1
type: Resource
database: PANTHER
comment: NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED
signature sequence match: PANTHER PTHR43571:SF1 match 1

PF00208
type: Resource
database: Pfam
comment: ELFV_dehydrog
signature sequence match: Pfam PF00208 match 1

PF02812
type: Resource
database: Pfam
comment: ELFV_dehydrog_N
signature sequence match: Pfam PF02812 match 1

PIRSF000185
type: Resource
database: PIRSF
comment: Glu_DH
signature sequence match: PIRSF PIRSF000185 match 1

PR00082
type: Resource
database: PRINTS
comment: GLFDHDRGNASE

SM00839
type: Resource
database: SMART
comment: ELFV_dehydrog
signature sequence match: SMART SM00839 match 1

SSF53223
type: Resource
database: SUPFAM
comment: Aminoacid dehydrogenase-like, N-terminal domain
signature sequence match: SUPFAM SSF53223 match 1

SSF51735
type: Resource
database: SUPFAM
comment: NAD(P)-binding Rossmann-fold domains
signature sequence match: SUPFAM SSF51735 match 1

PS00074
type: Resource
database: PROSITE
comment: GLFV_DEHYDROGENASE
signature sequence match: PROSITE PS00074 match 1

SIP59B6866FF99DC8BD
type: Structured Name
full name: NADP-specific glutamate dehydrogenase
short name: NADP-GDH
ec name: 1.4.1.4

SIP7136725369D3F0AF
type: Structured Name
full name: NADP-dependent glutamate dehydrogenase

SIP7FCB4CA7CD7C8E0A
type: Subunit Annotation
comment: Homohexamer.

SIPDCA9EA810670AFED
type: Similarity Annotation
comment: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

PRO_0000182786
type: Chain Annotation
comment: NADP-specific glutamate dehydrogenase
mass: 49766
range: 22573215162446894tt1tt449

22573215162446894tt1
type: Position
type: ExactPosition
position: 1
reference: P28724-1

22573215162446894tt449
type: Position
type: ExactPosition
position: 449
reference: P28724-1

22573215162446894tt125
type: Position
type: ExactPosition
position: 125
reference: P28724-1

SIPE88A92D6811B0053
type: Sequence Conflict Annotation
conflicting sequence: SIP5EB63BF1D48465E4
substitution: L
range: 22573215162446894tt249tt249

22573215162446894tt249
type: Position
type: ExactPosition
position: 249
reference: P28724-1

P28724-1
type: Simple Sequence
modified: 1992-12-01
version: 1
mass: 49766
value: MPAQTIEELIAVIKQRDGHMTEFRQAVEEVVDSLKVIFEREPKYIPIFERMLEPERVIIFRVPWMDDAGRINVNRGFRVQYNSALGPYKGGLRFHPSVNLSILKFLGFEQILKNSLTTLPMGGGKGGSDFDPKGKSDNEVMRFCQSFMTELQRHVGADTDVPAGDIGVGAREIGYLYGQYKRLRNEFTGVLTGKNVKWGGSFIRPEATGYGAVYFLEEMCKDNNTVIRGKNVLLSGSGNVAQFACEKLIQLGAKVLTFSDSNGTIVDKDGFNEEKLAHLMYLKNEKRGRVSEFKDKYPSVAYYEGKKPWECFEGQMDCIMPCATQNEVSGDDATRLVGLGLKFVAEGANMPSTAEAVHVYHAKGVMYGPAKASNAGGVSVSGLEMSQNSVRLQWTAEEVDQKLRGIMRGIFVACRDTAKKYGHPKNYQMGANIAGFLKVADSMIEQGCV

http://purl.uniprot.org/uniprot/P28724#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/P28724#attribution-BADDF98EA065AD20B73080651D54FDD4
manual: true
evidence: ECO_0000255
source: PRU10011

http://purl.uniprot.org/uniprot/P28724#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

Q95WU5
type: Protein
reviewed: true
created: 2013-01-09
modified: 2023-06-28
version: 74
mnemonic: DPP_GIAIN
replaces: A8BCK9
citation: http://purl.uniprot.org/citations/12049634
recommended name: SIPA38358E27AB08DDD
alternative name: SIPF933745A6D1B2C3E
alternative name: SIP13622D31146913C6
enzyme: http://purl.uniprot.org/enzyme/3.4.14.-
organism: http://purl.uniprot.org/taxonomy/5741
annotation: SIP16BE9F2337A80305
annotation: SIP47084FF45E22AEAE
annotation: SIP1A72EFDEAAD77CA5
annotation: SIP1C0501C042940E13
annotation: SIPB99551531E9D8455
annotation: SIP27AE928AB0123F69
annotation: PRO_0000420611
annotation: SIP437CEBE7D40EB407
annotation: SIPD6D4FE79E7E2E131
annotation: SIP063E927BA4A5B714
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/31
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/472
classified with: http://purl.uniprot.org/keywords/732
classified with: GO_0016020
classified with: GO_0004177
classified with: GO_0008236
classified with: GO_0006508
sequence: Q95WU5-1

Q95WU5-citation-12049634
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: PROTEIN SEQUENCE OF 256-266
scope: SUBCELLULAR LOCATION
scope: INDUCTION
scope: DEVELOPMENTAL STAGE

WB1267
type: Strain

giain-Q95WU5
type: Resource
database: ESTHER
comment: Prolyl_oligopeptidase_S9

KOG2100
type: Resource
database: eggNOG
comment: Eukaryota

http://purl.uniprot.org/gene3d/3.40.50.1820
type: Resource
database: Gene3D
comment: alpha/beta hydrolase
signature sequence match: Gene3D 3.40.50.1820 match 1

IPR029058
type: Resource
database: InterPro
comment: AB_hydrolase

IPR001375
type: Resource
database: InterPro
comment: Peptidase_S9

PTHR42776:SF13
type: Resource
database: PANTHER
comment: DIPEPTIDYL-PEPTIDASE 5
signature sequence match: PANTHER PTHR42776:SF13 match 1

PTHR42776
type: Resource
database: PANTHER
comment: SERINE PEPTIDASE S9 FAMILY MEMBER
signature sequence match: PANTHER PTHR42776 match 1

PF00326
type: Resource
database: Pfam
comment: Peptidase_S9
signature sequence match: Pfam PF00326 match 1

SSF53474
type: Resource
database: SUPFAM
comment: alpha/beta-Hydrolases
signature sequence match: SUPFAM SSF53474 match 1

SSF82171
type: Resource
database: SUPFAM
comment: DPP6 N-terminal domain-like
signature sequence match: SUPFAM SSF82171 match 1
signature sequence match: SUPFAM SSF82171 match 2

SIPA38358E27AB08DDD
type: Structured Name
full name: Dipeptidyl-peptidase 4
ec name: 3.4.14.-

SIPF933745A6D1B2C3E
type: Structured Name
full name: Dipeptidyl-aminopeptidase

SIP13622D31146913C6
type: Structured Name
full name: Dipeptidylpeptidase IV
short name: DPP IV

DPP
type: Gene

SIP16BE9F2337A80305
type: Function Annotation
comment: May be involved in metabolism of dipeptides or may affect host defense mechanisms.

SIP47084FF45E22AEAE
type: Subcellular Location Annotation
comment: Associated with trophozoite membrane.
located in: SIPE3DF58CADCBA3DEE

SIP1A72EFDEAAD77CA5
type: Developmental Stage Annotation
comment: Expressed throughout the life cycle, but expression is slightly decreased during encystation.

SIP1C0501C042940E13
type: Induction Annotation
comment: Expression increased in response to the protease inhibitor bestatin.

SIPB99551531E9D8455
type: Similarity Annotation
comment: Belongs to the peptidase S9C family.

22862374374815022tt1
type: Position
type: ExactPosition
position: 1
reference: Q95WU5-1

22862374374815022tt15
type: Position
type: ExactPosition
position: 15
reference: Q95WU5-1

PRO_0000420611
type: Chain Annotation
comment: Dipeptidyl-peptidase 4
mass: 86032
range: 22862374374815022tt16tt761

22862374374815022tt16
type: Position
type: ExactPosition
position: 16
reference: Q95WU5-1

22862374374815022tt761
type: Position
type: ExactPosition
position: 761
reference: Q95WU5-1

SIP437CEBE7D40EB407
type: Active Site Annotation
comment: Charge relay system
range: 22862374374815022tt622tt622

22862374374815022tt622
type: Position
type: ExactPosition
position: 622
reference: Q95WU5-1

SIPD6D4FE79E7E2E131
type: Active Site Annotation
comment: Charge relay system
range: 22862374374815022tt706tt706

22862374374815022tt706
type: Position
type: ExactPosition
position: 706
reference: Q95WU5-1

SIP063E927BA4A5B714
type: Active Site Annotation
comment: Charge relay system
range: 22862374374815022tt738tt738

22862374374815022tt738
type: Position
type: ExactPosition
position: 738
reference: Q95WU5-1

Q95WU5-1
type: Simple Sequence
modified: 2001-12-01
version: 1
precursor: true
mass: 87648
value: MTLSAWIILVTLAMASVLTPEDNVRLRRLTAYVANADASIVLLTYTEYEEGTNHGNSMLWRINDPLEAEYPFDPDDISLLNAERVCPELVGVGDLQYSTHNQAFYFTAQGPDGTSQVYSYNHKLETCTQISFLPISVSNLKVSPKGNSVLFSAEIFVYPNNHASVDDPLNFAHDEFARIQARPYKAFAYEQLYTRHWDEDILPSQYRHLFAARLERSSEYDDDYVRITVDNSIDLMPRFDGDCPMRPFADASSYTFDSHGRYVAFVTQVGSTAAFYTNDSIWITDLQQFLDAKKPVRDVVLPLRCATCWNKARDQRPAFSYDGIFLYYASMDEEQSESDLLRLRKQNVSDLFEYDCDSLFCGPVTGEGVFNLTAGVFDRSIGQFIIPTDSTEDSIYILAEDHARTNLFRYNEESSTVTRLTYNGTLGSLLYLRHNKIFLATMSSYTRPTDLVMLDLTVATEFTATRDPSDTMKDDLIKISYLTDLNRQRLRHIDELQEPEEFYLPSKSFPDQYVHSWYFAPANLRDSHEYPLILYVHGGPESPWANSWSYRWNPQLIAARGYGVLATNFHGSSSFGEVFQKSVRGNWYSYPLEDIMDAWSNIYTHADKAYLSREKVCAMGASFGATFMNYMNSHVNNVTCYVTHDGVFDTMCNALETDELFFPVRELGGFLLDEQVDNQQLYEKWNPARFVENMSAPMLVIHGQKDYRIQVYHGISLFQALRLRGIKTKLVYFPTQSHWVWQPQESLFWHTQVFDWLDTYL

http://purl.uniprot.org/uniprot/Q95WU5#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/Q95WU5#attribution-DC036A124EC8E88DF072B29F6D9BB9FE
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/Q95WU5#attribution-6047518F591F1203BBF2A7F7AF9899D5
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/12049634

http://purl.uniprot.org/uniprot/Q95WU5#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

http://purl.uniprot.org/uniprot/Q95WU5#attribution-193417FF2F35CC28067319E2C9A33E45
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/12049634

Q08046
type: Protein
reviewed: true
created: 1994-10-01
modified: 2023-09-13
version: 95
mnemonic: EF1A_GIAIN
old mnemonic: EF1A_GIALA
replaces: Q94838
citation: http://purl.uniprot.org/citations/8121287
citation: http://purl.uniprot.org/citations/8265589
recommended name: SIP6216CE0EFFB683CB
alternative name: SIPEF1F78C72C6849C3
organism: http://purl.uniprot.org/taxonomy/5741
annotation: SIP31CAD83DDF67FA8B
annotation: SIPCA9D66D3A2686DDE
annotation: SIPAEFAE0506894A193
annotation: PRO_0000090925
annotation: SIPFDF6911339FC8979
annotation: SIPC1B7CBFC2F8A2A8F
annotation: SIP5B69D94BB10DBF1C
annotation: SIPC7B85DC3EF150A29
annotation: SIP3C65577C97B96143
existence: Evidence at Transcript Level Existence
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/251
classified with: http://purl.uniprot.org/keywords/342
classified with: GO_0005737
classified with: GO_0005525
classified with: GO_0003924
classified with: GO_0003746
sequence: Q08046-1

Q08046-citation-8121287
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA]

Q08046-citation-8265589
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 40-273

KOG0052
type: Resource
database: eggNOG
comment: Eukaryota

cd01883
type: Resource
database: CDD
comment: EF1_alpha
signature sequence match: CDD cd01883 match 1

cd03693
type: Resource
database: CDD
comment: EF1_alpha_II
signature sequence match: CDD cd03693 match 1

cd03705
type: Resource
database: CDD
comment: EF1_alpha_III
signature sequence match: CDD cd03705 match 1

http://purl.uniprot.org/gene3d/2.40.30.10
type: Resource
database: Gene3D
comment: Translation factors
signature sequence match: Gene3D 2.40.30.10 match 1
signature sequence match: Gene3D 2.40.30.10 match 2

IPR004161
type: Resource
database: InterPro
comment: EFTu-like_2

IPR031157
type: Resource
database: InterPro
comment: G_TR_CS

IPR000795
type: Resource
database: InterPro
comment: T_Tr_GTP-bd_dom

IPR009000
type: Resource
database: InterPro
comment: Transl_B-barrel_sf

IPR009001
type: Resource
database: InterPro
comment: Transl_elong_EF1A/Init_IF2_C

IPR004539
type: Resource
database: InterPro
comment: Transl_elong_EF1A_euk/arc

IPR004160
type: Resource
database: InterPro
comment: Transl_elong_EFTu/EF1A_C

TIGR00483
type: Resource
database: NCBIfam
comment: EF-1_alpha
signature sequence match: NCBIfam TIGR00483 match 1

PTHR23115:SF170
type: Resource
database: PANTHER
comment: ELONGATION FACTOR 1-ALPHA 2
signature sequence match: PANTHER PTHR23115:SF170 match 1

PTHR23115
type: Resource
database: PANTHER
comment: TRANSLATION FACTOR
signature sequence match: PANTHER PTHR23115 match 1

PF00009
type: Resource
database: Pfam
comment: GTP_EFTU
signature sequence match: Pfam PF00009 match 1

PF03144
type: Resource
database: Pfam
comment: GTP_EFTU_D2
signature sequence match: Pfam PF03144 match 1

PF03143
type: Resource
database: Pfam
comment: GTP_EFTU_D3
signature sequence match: Pfam PF03143 match 1

PR00315
type: Resource
database: PRINTS
comment: ELONGATNFCT

SSF50465
type: Resource
database: SUPFAM
comment: EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
signature sequence match: SUPFAM SSF50465 match 1

SSF50447
type: Resource
database: SUPFAM
comment: Translation proteins
signature sequence match: SUPFAM SSF50447 match 1

PS00301
type: Resource
database: PROSITE
comment: G_TR_1
signature sequence match: PROSITE PS00301 match 1

PS51722
type: Resource
database: PROSITE
comment: G_TR_2
signature sequence match: PROSITE PS51722 match 1

SIP6216CE0EFFB683CB
type: Structured Name
full name: Elongation factor 1-alpha
short name: EF-1-alpha

SIPEF1F78C72C6849C3
type: Structured Name
full name: 14 nm filament-associated protein

TEF1
type: Gene

SIP31CAD83DDF67FA8B
type: Function Annotation
comment: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

SIPAEFAE0506894A193
type: Similarity Annotation
comment: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

PRO_0000090925
type: Chain Annotation
comment: Elongation factor 1-alpha
mass: 43951
range: 22852490998593070tf1tf396

22852490998593070tt1
type: Position
type: ExactPosition
position: 1
reference: Q08046-1

22852490998593070tt396
type: Position
type: ExactPosition
position: 396
reference: Q08046-1

SIPFDF6911339FC8979
type: Domain Extent Annotation
comment: tr-type G
range: 22852490998593070tf1tt211

22852490998593070tt211
type: Position
type: ExactPosition
position: 211
reference: Q08046-1

22852490998593070tt71
type: Position
type: ExactPosition
position: 71
reference: Q08046-1

22852490998593070tt75
type: Position
type: ExactPosition
position: 75
reference: Q08046-1

22852490998593070tt133
type: Position
type: ExactPosition
position: 133
reference: Q08046-1

22852490998593070tt136
type: Position
type: ExactPosition
position: 136
reference: Q08046-1

Q08046-1
type: Simple Sequence
modified: 1994-10-01
version: 1
fragment: single
mass: 43951
value: STLTGHLIYKCGGIDQRTIDEYEKRATEMGKGSFKYAWVLDQLKDERERGITINIALWKFETKKYIVTIIDAPGHRDFIKNMITGTSQADVAILVVAAGQGEFEAGISKDGQTREHATLANTLGIKTMIICVNKMDDGQVKYSKERYDEIKGEMMKQLKNIGWKKAEEFDYIPTSGWTGDNIMEKSDKMPWYEGPCLIDAIDGLKAPKRPTDKPLRLPIQDVYKISGVGTVPAGRVETGELAPGMKVVFAPTSQVSEVKSVEMHHEELKKAGPGDNVGFNVRGLAVKDLKKGYVVGDVTNDPPVGCKSFTAQVIVMNHPKKIQPGYTPVIDCHTAHIACQFQLFLQKLDKRTLKPEMENPPDAGRGDCIIVKMVPQKPLCCETFNDYAPLGPFAVR

http://purl.uniprot.org/uniprot/Q08046#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/Q08046#attribution-295AA0C5B431478393D637E04D4F628A
manual: true
evidence: ECO_0000255
source: PRU01059

Q9NCP1
type: Protein
reviewed: true
created: 2001-08-14
modified: 2023-09-13
version: 72
mnemonic: ERF1_GIAIN
old mnemonic: ERF1_GIALA
citation: http://purl.uniprot.org/citations/10833194
recommended name: SIP435F6160AD12943E
organism: http://purl.uniprot.org/taxonomy/5741
annotation: SIPFF688E9DF6091E57
annotation: SIP3340B3829406DF5F
annotation: SIP5F9BB495C4DFF967
annotation: SIP249C263CE77DDF76
annotation: PRO_0000143154
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/648
classified with: GO_0005737
classified with: GO_0003747
sequence: Q9NCP1-1

Q9NCP1-citation-10833194
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

KOG0688
type: Resource
database: eggNOG
comment: Eukaryota

http://purl.uniprot.org/gene3d/3.30.960.10
type: Resource
database: Gene3D
comment: eRF1 domain 1
signature sequence match: Gene3D 3.30.960.10 match 1

http://purl.uniprot.org/gene3d/3.30.420.60
type: Resource
database: Gene3D
comment: eRF1 domain 2
signature sequence match: Gene3D 3.30.420.60 match 1

IPR042226
type: Resource
database: InterPro
comment: eFR1_2_sf

IPR005140
type: Resource
database: InterPro
comment: eRF1_1_Pelota

IPR024049
type: Resource
database: InterPro
comment: eRF1_1_sf

IPR005141
type: Resource
database: InterPro
comment: eRF1_2

IPR005142
type: Resource
database: InterPro
comment: eRF1_3

IPR029064
type: Resource
database: InterPro
comment: L30e-like

IPR004403
type: Resource
database: InterPro
comment: Peptide_chain-rel_eRF1/aRF1

TIGR03676
type: Resource
database: NCBIfam
comment: aRF1_eRF1
signature sequence match: NCBIfam TIGR03676 match 1

PTHR10113:SF10
type: Resource
database: PANTHER
comment: EUKARYOTIC PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1
signature sequence match: PANTHER PTHR10113:SF10 match 1

PTHR10113
type: Resource
database: PANTHER
comment: PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1
signature sequence match: PANTHER PTHR10113 match 1

PF03463
type: Resource
database: Pfam
comment: eRF1_1
signature sequence match: Pfam PF03463 match 1

PF03464
type: Resource
database: Pfam
comment: eRF1_2
signature sequence match: Pfam PF03464 match 1

PF03465
type: Resource
database: Pfam
comment: eRF1_3
signature sequence match: Pfam PF03465 match 1

SM01194
type: Resource
database: SMART
comment: eRF1_1
signature sequence match: SMART SM01194 match 1

SSF55315
type: Resource
database: SUPFAM
comment: L30e-like
signature sequence match: SUPFAM SSF55315 match 1

SSF55481
type: Resource
database: SUPFAM
comment: N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1
signature sequence match: SUPFAM SSF55481 match 1

SSF53137
type: Resource
database: SUPFAM
comment: Translational machinery components
signature sequence match: SUPFAM SSF53137 match 1

SIP435F6160AD12943E
type: Structured Name
full name: Eukaryotic peptide chain release factor subunit 1
short name: Eukaryotic release factor 1
short name: eRF1

ERF1
type: Gene

SIPFF688E9DF6091E57
type: Function Annotation
comment: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.

SIP3340B3829406DF5F
type: Subunit Annotation
comment: Heterodimer of two subunits, one of which binds GTP.

SIP249C263CE77DDF76
type: Similarity Annotation
comment: Belongs to the eukaryotic release factor 1 family.

PRO_0000143154
type: Chain Annotation
comment: Eukaryotic peptide chain release factor subunit 1
mass: 51029
range: 22862481413124398tt1tt457

22862481413124398tt1
type: Position
type: ExactPosition
position: 1
reference: Q9NCP1-1

22862481413124398tt457
type: Position
type: ExactPosition
position: 457
reference: Q9NCP1-1

Q9NCP1-1
type: Simple Sequence
modified: 2000-10-01
version: 1
mass: 51029
value: MSINPDAPQSNGEQERQIAIWQLKRTIEKLESYTGSGTSVISLLIPPGEQLSSVTGMLTNEYGTASNIKSRVNKNAVLSAITSAMSRLKLYNRLPPNGLAVYCGEIEEDGKNTKVVIDYTPYKPISNFIYLCDSKFHTEHLRELLTNDDTFGFIIMDGKETLMATLSGTVRTILDRSTVDLPKKHGRGGQSSVRFARLREEARHNYVRKVAERANSLFISSGPTGTNKPIVSGLILGGSADFKNVLSTSAIFDQRLQSIVMKQIDINYGGEQGFNQAIEMAGDTLKDVKLIQEVKLLTEFTENIAKDTKRVCFGITDTIRCLEMSAVEKLIVWDDLPYHRVTLQCVINGETSAPVIKYLLKSQMSNPKYLREVINGEEVQLDIMGDQLLLEWFVDNYKNYGASLEFITNRSAEGTQFCSGFGGIGGLLRWQVDLVEAARFMQESDEDSFMDDLEDFI

http://purl.uniprot.org/uniprot/Q9NCP1#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/Q9NCP1#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

Q24957
type: Protein
reviewed: true
created: 1997-11-01
modified: 2023-06-28
version: 83
mnemonic: FBRL_GIAIN
old mnemonic: FBRL_GIALA
citation: http://purl.uniprot.org/citations/9495039
recommended name: SIP7253687BE1B154D2
alternative name: SIP6DAADC001ECBB209
enzyme: http://purl.uniprot.org/enzyme/2.1.1.-
organism: http://purl.uniprot.org/taxonomy/5741
annotation: SIP6E474770191A74CA
annotation: SIPFDD52E779C808A31
annotation: SIP59257B53B9B0C56F
annotation: SIP1374D3A2F128FC64
annotation: SIPC6F34782A243B124
annotation: SIP7B0972B4F6C058D7
annotation: PRO_0000148514
annotation: SIP65842F0293BD3176
annotation: SIPB4E0B878C9A65C53
annotation: SIP0006348F6DA5EF8D
annotation: SIP8575B68AF5D56433
annotation: SIPB11AE727772F25D8
annotation: SIP9940CFEEFDA0CCC3
annotation: SIP123ACAC93FCC238C
annotation: SIP6DC2AABCC5016E76
annotation: SIPF325AF1D47620201
annotation: SIP371AD90E3C72C919
annotation: SIP983064A07B9BF52D
annotation: SIP5B1F92BB42CFDDA6
annotation: SIP651102CF348FEFBD
annotation: SIP3B7254EC6886DCC4
annotation: SIP44531185B5299C4C
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/488
classified with: http://purl.uniprot.org/keywords/489
classified with: http://purl.uniprot.org/keywords/539
classified with: http://purl.uniprot.org/keywords/687
classified with: http://purl.uniprot.org/keywords/694
classified with: http://purl.uniprot.org/keywords/698
classified with: http://purl.uniprot.org/keywords/949
classified with: GO_0005730
classified with: GO_1990904
classified with: GO_0008168
classified with: GO_0003723
classified with: GO_0032259
classified with: GO_0006364
sequence: Q24957-1

Q24957-citation-9495039
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

ATCC 30957 / WB
type: Strain

KOG1596
type: Resource
database: eggNOG
comment: Eukaryota

http://purl.uniprot.org/gene3d/3.40.50.150
type: Resource
database: Gene3D
comment: Vaccinia Virus protein VP39
signature sequence match: Gene3D 3.40.50.150 match 1

MF_00351
type: Resource
database: HAMAP
comment: RNA_methyltransf_FlpA
signature sequence match: HAMAP MF 00351 match 1

IPR000692
type: Resource
database: InterPro
comment: Fibrillarin

IPR020813
type: Resource
database: InterPro
comment: Fibrillarin_CS

IPR029063
type: Resource
database: InterPro
comment: SAM-dependent_MTases_sf

PTHR10335:SF17
type: Resource
database: PANTHER
comment: FIBRILLARIN
signature sequence match: PANTHER PTHR10335:SF17 match 1

PTHR10335
type: Resource
database: PANTHER
comment: RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN
signature sequence match: PANTHER PTHR10335 match 1

PF01269
type: Resource
database: Pfam
comment: Fibrillarin
signature sequence match: Pfam PF01269 match 1

PR00052
type: Resource
database: PRINTS
comment: FIBRILLARIN

SM01206
type: Resource
database: SMART
comment: Fibrillarin
signature sequence match: SMART SM01206 match 1

SSF53335
type: Resource
database: SUPFAM
comment: S-adenosyl-L-methionine-dependent methyltransferases
signature sequence match: SUPFAM SSF53335 match 1

PS00566
type: Resource
database: PROSITE
comment: FIBRILLARIN
signature sequence match: PROSITE PS00566 match 1

SIP7253687BE1B154D2
type: Structured Name
full name: rRNA 2'-O-methyltransferase fibrillarin
ec name: 2.1.1.-

SIP6DAADC001ECBB209
type: Structured Name
full name: Histone-glutamine methyltransferase

SIP6E474770191A74CA
type: Function Annotation
comment: S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (By similarity).

SIP59257B53B9B0C56F
type: Subunit Annotation
comment: Component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. It is associated with the U3, U8 and U13 small nuclear RNAs.

SIP1374D3A2F128FC64
type: Subcellular Location Annotation
comment: Fibrillar region of the nucleolus.
located in: SIPC255840BB3731D4F

SIPC6F34782A243B124
type: PTM Annotation
comment: By homology to other fibrillarins, some or all of the N-terminal domain arginines are modified to asymmetric dimethylarginine (DMA).

SIP7B0972B4F6C058D7
type: Similarity Annotation
comment: Belongs to the methyltransferase superfamily. Fibrillarin family.

PRO_0000148514
type: Chain Annotation
comment: rRNA 2'-O-methyltransferase fibrillarin
mass: 35243
range: 22854672993040174tt1tt327

22854672993040174tt1
type: Position
type: ExactPosition
position: 1
reference: Q24957-1

22854672993040174tt327
type: Position
type: ExactPosition
position: 327
reference: Q24957-1

SIP65842F0293BD3176
type: Region Annotation
comment: Disordered
range: 22854672993040174tt1tt96

22854672993040174tt96
type: Position
type: ExactPosition
position: 96
reference: Q24957-1

SIPB4E0B878C9A65C53
type: Compositional Bias Annotation
comment: Basic and acidic residues
range: 22854672993040174tt19tt51

22854672993040174tt19
type: Position
type: ExactPosition
position: 19
reference: Q24957-1

22854672993040174tt51
type: Position
type: ExactPosition
position: 51
reference: Q24957-1

SIP0006348F6DA5EF8D
type: Compositional Bias Annotation
comment: Basic and acidic residues
range: 22854672993040174tt60tt74

22854672993040174tt60
type: Position
type: ExactPosition
position: 60
reference: Q24957-1

22854672993040174tt74
type: Position
type: ExactPosition
position: 74
reference: Q24957-1

22854672993040174tt181
type: Position
type: ExactPosition
position: 181
reference: Q24957-1

22854672993040174tt182
type: Position
type: ExactPosition
position: 182
reference: Q24957-1

22854672993040174tt200
type: Position
type: ExactPosition
position: 200
reference: Q24957-1

22854672993040174tt201
type: Position
type: ExactPosition
position: 201
reference: Q24957-1

22854672993040174tt225
type: Position
type: ExactPosition
position: 225
reference: Q24957-1

22854672993040174tt226
type: Position
type: ExactPosition
position: 226
reference: Q24957-1

22854672993040174tt245
type: Position
type: ExactPosition
position: 245
reference: Q24957-1

22854672993040174tt248
type: Position
type: ExactPosition
position: 248
reference: Q24957-1

SIP6DC2AABCC5016E76
type: Modified Residue Annotation
comment: Asymmetric dimethylarginine
range: 22854672993040174tt10tt10

22854672993040174tt10
type: Position
type: ExactPosition
position: 10
reference: Q24957-1

SIPF325AF1D47620201
type: Modified Residue Annotation
comment: Asymmetric dimethylarginine
range: 22854672993040174tt19tt19

SIP371AD90E3C72C919
type: Modified Residue Annotation
comment: Asymmetric dimethylarginine
range: 22854672993040174tt44tt44

22854672993040174tt44
type: Position
type: ExactPosition
position: 44
reference: Q24957-1

SIP983064A07B9BF52D
type: Modified Residue Annotation
comment: Asymmetric dimethylarginine
range: 22854672993040174tt49tt49

22854672993040174tt49
type: Position
type: ExactPosition
position: 49
reference: Q24957-1

SIP5B1F92BB42CFDDA6
type: Modified Residue Annotation
comment: Asymmetric dimethylarginine
range: 22854672993040174tt55tt55

22854672993040174tt55
type: Position
type: ExactPosition
position: 55
reference: Q24957-1

SIP651102CF348FEFBD
type: Modified Residue Annotation
comment: Asymmetric dimethylarginine
range: 22854672993040174tt65tt65

22854672993040174tt65
type: Position
type: ExactPosition
position: 65
reference: Q24957-1

SIP3B7254EC6886DCC4
type: Modified Residue Annotation
comment: Asymmetric dimethylarginine
range: 22854672993040174tt69tt69

22854672993040174tt69
type: Position
type: ExactPosition
position: 69
reference: Q24957-1

SIP44531185B5299C4C
type: Modified Residue Annotation
comment: Asymmetric dimethylarginine
range: 22854672993040174tt78tt78

22854672993040174tt78
type: Position
type: ExactPosition
position: 78
reference: Q24957-1

Q24957-1
type: Simple Sequence
modified: 1996-11-01
version: 1
mass: 35243
value: MGTDYRNSGRGGRDGPGGRGPGNDRRDSGRSFGDRRPERPDFKRGDGGRGFGDRRGSGPPGGPDRGDRRGPRDGPGGRGGPGGPGGGFKGGAKTMVKPHPKYDGIFISHGRGDVLVTKSLAPGVAVYGEKRISVEGTESKIEYREWNPFRSKLGAAVRLNVLDMPIKPGAKVLYLGAASGTTVSHVSDIVGPTGAVYAVEFSQRSGRDLLEVAKARTNVYPIIADARHPYKYRMIVPEVDCIFSDVAQPDQARIVAENARYYLKANGGMLISIKASSVDSTLKPEAVFAREIETLREHDFKCKEQLDIGEFHRNHAIVVGRFRVKAA

http://purl.uniprot.org/uniprot/Q24957#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/Q24957#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

A8B672
type: Protein
reviewed: true
created: 2011-01-11
modified: 2023-06-28
version: 79
mnemonic: FEN1_GIAIC
old mnemonic: FEN1_GIAIN
citation: http://purl.uniprot.org/citations/17901334
recommended name: SIPD0F3B4537BEF6488
alternative name: SIPD6CD844568711308
enzyme: http://purl.uniprot.org/enzyme/3.1.-.-
organism: http://purl.uniprot.org/taxonomy/184922
annotation: SIPAFF15764F38CEC34
annotation: SIP34FE81505841583D
annotation: SIP3966BAFDA00D9E21
annotation: SIP4A09403C6484316F
annotation: SIP3D01354EC82D4660
annotation: SIPE6B03FD16486E7B4
annotation: PRO_0000403611
annotation: SIP0E12DDDDB35B2771
annotation: SIPDD916A87536191B7
annotation: SIPAF334790250B2400
annotation: SIP7A452F8CBD357F9A
annotation: SIP7E89777F4FB4AC09
annotation: SIPEC5B52E710C2DB18
annotation: SIP394B76103E6D2181
annotation: SIP5D01153436D6A787
annotation: SIP434791FAAC8B886F
annotation: SIP75A8DAA89B790F6F
annotation: SIP06126E95851DD49E
annotation: SIPF3AB0D2AFC50B46D
annotation: SIP10D5FC49563D7F8F
annotation: SIPC0CDBDB3125281E1
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/234
classified with: http://purl.uniprot.org/keywords/235
classified with: http://purl.uniprot.org/keywords/255
classified with: http://purl.uniprot.org/keywords/269
classified with: http://purl.uniprot.org/keywords/460
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/496
classified with: http://purl.uniprot.org/keywords/539
classified with: http://purl.uniprot.org/keywords/597
classified with: GO_0005739
classified with: GO_0005730
classified with: GO_0005654
classified with: GO_0008409
classified with: GO_0017108
classified with: GO_0003677
classified with: GO_0000287
classified with: GO_0006284
classified with: GO_0043137
sequence: http://purl.uniprot.org/isoforms/A8B672-1

A8B672-citation-17901334
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

ATCC 50803 / WB clone C6
type: Strain

cd09907
type: Resource
database: CDD
comment: H3TH_FEN1-Euk
signature sequence match: CDD cd09907 match 1

cd09867
type: Resource
database: CDD
comment: PIN_FEN1
signature sequence match: CDD cd09867 match 1

http://purl.uniprot.org/gene3d/1.10.150.20
type: Resource
database: Gene3D
comment: 5' to 3' exonuclease, C-terminal subdomain
signature sequence match: Gene3D 1.10.150.20 match 1

http://purl.uniprot.org/gene3d/3.40.50.1010
type: Resource
database: Gene3D
comment: 5'-nuclease
signature sequence match: Gene3D 3.40.50.1010 match 1

MF_00614
type: Resource
database: HAMAP
comment: Fen
signature sequence match: HAMAP MF 00614 match 1

IPR002421
type: Resource
database: InterPro
comment: 5-3_exonuclease

IPR036279
type: Resource
database: InterPro
comment: 5-3_exonuclease_C_sf

IPR023426
type: Resource
database: InterPro
comment: Flap_endonuc

IPR008918
type: Resource
database: InterPro
comment: HhH2

IPR029060
type: Resource
database: InterPro
comment: PIN-like_dom_sf

IPR006086
type: Resource
database: InterPro
comment: XPG-I_dom

IPR006084
type: Resource
database: InterPro
comment: XPG/Rad2

IPR006085
type: Resource
database: InterPro
comment: XPG_DNA_repair_N

PTHR11081:SF9
type: Resource
database: PANTHER
comment: FLAP ENDONUCLEASE 1
signature sequence match: PANTHER PTHR11081:SF9 match 1

PTHR11081
type: Resource
database: PANTHER
comment: FLAP ENDONUCLEASE FAMILY MEMBER
signature sequence match: PANTHER PTHR11081 match 1

PF00867
type: Resource
database: Pfam
comment: XPG_I
signature sequence match: Pfam PF00867 match 1

PF00752
type: Resource
database: Pfam
comment: XPG_N
signature sequence match: Pfam PF00752 match 1

PR00853
type: Resource
database: PRINTS
comment: XPGRADSUPER

SM00475
type: Resource
database: SMART
comment: 53EXOc
signature sequence match: SMART SM00475 match 1

SM00279
type: Resource
database: SMART
comment: HhH2
signature sequence match: SMART SM00279 match 1

SM00484
type: Resource
database: SMART
comment: XPGI
signature sequence match: SMART SM00484 match 1

SM00485
type: Resource
database: SMART
comment: XPGN
signature sequence match: SMART SM00485 match 1

SSF47807
type: Resource
database: SUPFAM
comment: 5' to 3' exonuclease, C-terminal subdomain
signature sequence match: SUPFAM SSF47807 match 1

SSF88723
type: Resource
database: SUPFAM
comment: PIN domain-like
signature sequence match: SUPFAM SSF88723 match 1

SIPD0F3B4537BEF6488
type: Structured Name
full name: Flap endonuclease 1
short name: FEN-1
ec name: 3.1.-.-

SIPD6CD844568711308
type: Structured Name
full name: Flap structure-specific endonuclease 1

FEN1
type: Gene
orf name: GL50803_16953

SIPAFF15764F38CEC34
type: Function Annotation
comment: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.

SIP34FE81505841583D
type: Cofactor Annotation
comment: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
cofactor: CHEBI_18420

SIP3966BAFDA00D9E21
type: Subunit Annotation
comment: Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.

SIP4A09403C6484316F
type: Subcellular Location Annotation
comment: Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
located in: SIPCDA9A13819F90335
located in: SIP4DCB3647851242B8
located in: SIP2C0DEAC8C1E35A0D

SIP3D01354EC82D4660
type: PTM Annotation
comment: Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma.

SIPE6B03FD16486E7B4
type: Similarity Annotation
comment: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

PRO_0000403611
type: Chain Annotation
comment: Flap endonuclease 1
mass: 40030
range: 18357730514776622tt1tt361

18357730514776622tt1
type: Position
type: ExactPosition
position: 1
reference: http://purl.uniprot.org/isoforms/A8B672-1

18357730514776622tt361
type: Position
type: ExactPosition
position: 361
reference: http://purl.uniprot.org/isoforms/A8B672-1

SIP0E12DDDDB35B2771
type: Region Annotation
comment: N-domain
range: 18357730514776622tt1tt105

18357730514776622tt105
type: Position
type: ExactPosition
position: 105
reference: http://purl.uniprot.org/isoforms/A8B672-1

SIPDD916A87536191B7
type: Region Annotation
comment: I-domain
range: 18357730514776622tt123tt252

18357730514776622tt123
type: Position
type: ExactPosition
position: 123
reference: http://purl.uniprot.org/isoforms/A8B672-1

18357730514776622tt252
type: Position
type: ExactPosition
position: 252
reference: http://purl.uniprot.org/isoforms/A8B672-1

SIPAF334790250B2400
type: Region Annotation
comment: Interaction with PCNA
range: 18357730514776622tt337tt345

18357730514776622tt337
type: Position
type: ExactPosition
position: 337
reference: http://purl.uniprot.org/isoforms/A8B672-1

18357730514776622tt345
type: Position
type: ExactPosition
position: 345
reference: http://purl.uniprot.org/isoforms/A8B672-1

SIP7A452F8CBD357F9A
type: Region Annotation
comment: Disordered
range: 18357730514776622tt341tt361

18357730514776622tt341
type: Position
type: ExactPosition
position: 341
reference: http://purl.uniprot.org/isoforms/A8B672-1

18357730514776622tt34
type: Position
type: ExactPosition
position: 34
reference: http://purl.uniprot.org/isoforms/A8B672-1

18357730514776622tt87
type: Position
type: ExactPosition
position: 87
reference: http://purl.uniprot.org/isoforms/A8B672-1

18357730514776622tt159
type: Position
type: ExactPosition
position: 159
reference: http://purl.uniprot.org/isoforms/A8B672-1

18357730514776622tt161
type: Position
type: ExactPosition
position: 161
reference: http://purl.uniprot.org/isoforms/A8B672-1

18357730514776622tt180
type: Position
type: ExactPosition
position: 180
reference: http://purl.uniprot.org/isoforms/A8B672-1

18357730514776622tt182
type: Position
type: ExactPosition
position: 182
reference: http://purl.uniprot.org/isoforms/A8B672-1

18357730514776622tt230
type: Position
type: ExactPosition
position: 230
reference: http://purl.uniprot.org/isoforms/A8B672-1

18357730514776622tt232
type: Position
type: ExactPosition
position: 232
reference: http://purl.uniprot.org/isoforms/A8B672-1

1
subclass of: CHEBI_18420

2
subclass of: CHEBI_18420

http://purl.uniprot.org/isoforms/A8B672-1
type: Simple Sequence
modified: 2007-11-13
version: 1
mass: 40030
value: MGIRGLAKLIEEVAPAAVSKRLIQHYCNKVIAIDASVMLYQFITTITSGDGTALANSSGEVTSHLVGLLAKVIRLAEAGIKPIFVFDGKPPEDKQGELEKRRQAREAAELEQQKAEEEGNLERAKQLSRRTVKVTQQHCKQAERLLDTLGIPYVVAAGEAEAQCVAMAKERVCEGVASSDLDVLAFGSPCLIRNLAQGGDREIVEINLNTVLKELGFSYDEFLDLCILCGCDYANSLEGIGPKTAYKLIVKHRSIEEVLAADQGKLAEKALNWPYVRARELFKNPAVIDPKEIKKTLKWKPVNRGEAMQFLVEEMEFDRETTEKKLDKLVAARKKPKQCTIDSFFSPRSSNPEVTKTKVKQ

http://purl.uniprot.org/uniprot/A8B672#attribution-28C4C5067FDD2C7EC39F63B6297C2FDA
manual: true
evidence: ECO_0000255
source: MF_03140

P21149
type: Protein
reviewed: true
created: 1991-05-01
modified: 2023-05-03
version: 101
mnemonic: FER_TRIVA
citation: http://purl.uniprot.org/citations/1696716
citation: http://purl.uniprot.org/citations/12051855
recommended name: SIPC4C93E5D1954033D
organism: http://purl.uniprot.org/taxonomy/5722
annotation: SIP07379CB7E886EFAF
annotation: SIPE596DD52962BC3D6
annotation: SIP2A4E9DD600C561B2
annotation: SIP939AEFE988B41029
annotation: PRO_0000008841
annotation: PRO_0000008842
annotation: SIPA6D7E713C63111C3
annotation: SIP077FB6E864F0C2FA
annotation: SIPB96162BDB23368C7
annotation: SIPE43B1135A829F45B
annotation: SIPD5AC2B9C5601BCEA
annotation: SIPA304809AA761A90D
annotation: SIP835AEFE1D52A7F2C
annotation: SIPD7D2F22E5BA1D351
annotation: SIPC9C3D86772CEB327
annotation: SIP3BB7B7CBBEDF2ECB
annotation: SIP1A18644D9A057021
annotation: SIP9CDFBA2877FA3277
annotation: SIP1BE634538BFBFC7F
annotation: SIP3F9629478258C55B
annotation: SIP624DBEBEE4A1BA4E
annotation: SIPE9A7B65A793D98D4
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/1
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/249
classified with: http://purl.uniprot.org/keywords/377
classified with: GO_0042566
classified with: GO_0051537
classified with: GO_0046872
sequence: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

P21149-citation-1696716
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: PROTEIN SEQUENCE OF 9-100

ATCC 30001 / NIH-C1
type: Strain

P21149-citation-12051855
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 9-100

1L5P
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.20
chain sequence mapping: PDB 1L5P tt9tt100

PDB 1L5P tt9tt100
chain: A/B/C=9-100

cd00207
type: Resource
database: CDD
comment: fer2
signature sequence match: CDD cd00207 match 1

IPR036010
type: Resource
database: InterPro
comment: 2Fe-2S_ferredoxin-like_sf

IPR001041
type: Resource
database: InterPro
comment: 2Fe-2S_ferredoxin-type

IPR012675
type: Resource
database: InterPro
comment: Beta-grasp_dom_sf

PF00111
type: Resource
database: Pfam
comment: Fer2
signature sequence match: Pfam PF00111 match 1

SSF54292
type: Resource
database: SUPFAM
comment: 2Fe-2S ferredoxin-like
signature sequence match: SUPFAM SSF54292 match 1

PS51085
type: Resource
database: PROSITE
comment: 2FE2S_FER_2
signature sequence match: PROSITE PS51085 match 1

SIPC4C93E5D1954033D
type: Structured Name
full name: Ferredoxin

SIP07379CB7E886EFAF
type: Function Annotation
comment: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. It links pyruvate:ferredoxin oxidoreductase to hydrogenase.

SIPE596DD52962BC3D6
type: Cofactor Annotation
comment: Binds 1 [2Fe-2S] cluster.
cofactor: CHEBI_190135

SIP939AEFE988B41029
type: Annotation
comment: The propeptide may play a role in the targeting of this protein to the organelle.

22573184997144878tt1
type: Position
type: ExactPosition
position: 1
reference: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

22573184997144878tt8
type: Position
type: ExactPosition
position: 8
reference: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

PRO_0000008842
type: Chain Annotation
comment: Ferredoxin
mass: 9710
range: 22573184997144878tt9tt100

22573184997144878tt9
type: Position
type: ExactPosition
position: 9
reference: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

22573184997144878tt100
type: Position
type: ExactPosition
position: 100
reference: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

SIPA6D7E713C63111C3
type: Domain Extent Annotation
comment: 2Fe-2S ferredoxin-type
range: 22573184997144878tt9tt100

22573184997144878tt46
type: Position
type: ExactPosition
position: 46
reference: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

22573184997144878tt52
type: Position
type: ExactPosition
position: 52
reference: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

22573184997144878tt55
type: Position
type: ExactPosition
position: 55
reference: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

22573184997144878tt85
type: Position
type: ExactPosition
position: 85
reference: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

22573184997144878tt10
type: Position
type: ExactPosition
position: 10
reference: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

22573184997144878tt15
type: Position
type: ExactPosition
position: 15
reference: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

22573184997144878tt18
type: Position
type: ExactPosition
position: 18
reference: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

22573184997144878tt23
type: Position
type: ExactPosition
position: 23
reference: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

22573184997144878tt30
type: Position
type: ExactPosition
position: 30
reference: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

22573184997144878tt35
type: Position
type: ExactPosition
position: 35
reference: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

22573184997144878tt36
type: Position
type: ExactPosition
position: 36
reference: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

22573184997144878tt38
type: Position
type: ExactPosition
position: 38
reference: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

22573184997144878tt47
type: Position
type: ExactPosition
position: 47
reference: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

22573184997144878tt56
type: Position
type: ExactPosition
position: 56
reference: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

22573184997144878tt62
type: Position
type: ExactPosition
position: 62
reference: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

22573184997144878tt68
type: Position
type: ExactPosition
position: 68
reference: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

22573184997144878tt74
type: Position
type: ExactPosition
position: 74
reference: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

22573184997144878tt81
type: Position
type: ExactPosition
position: 81
reference: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

22573184997144878tt83
type: Position
type: ExactPosition
position: 83
reference: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

22573184997144878tt84
type: Position
type: ExactPosition
position: 84
reference: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

22573184997144878tt86
type: Position
type: ExactPosition
position: 86
reference: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

22573184997144878tt91
type: Position
type: ExactPosition
position: 91
reference: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

22573184997144878tt93
type: Position
type: ExactPosition
position: 93
reference: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

22573184997144878tt97
type: Position
type: ExactPosition
position: 97
reference: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

22573184997144878tt99
type: Position
type: ExactPosition
position: 99
reference: MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL

MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL
type: Simple Sequence
modified: 1991-05-01
version: 1
precursor: true
mass: 10675

http://purl.uniprot.org/uniprot/P21149#attribution-4C287B5EE055C53751B747804F0BDCE6
manual: true
evidence: ECO_0000255
source: PRU00465

http://purl.uniprot.org/uniprot/P21149#attribution-DA459C30114A4CDBA39F6B38B8A376FD
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/1696716

P53429
type: Protein
reviewed: true
created: 1996-10-01
modified: 2023-09-13
version: 105
mnemonic: G3P1_GIAIN
old mnemonic: G3P1_GIALA
citation: SIP8FAECCFD7EC6EE84
citation: SIPA93BEAEC77A42C50
recommended name: SIP2440615DD4268354
enzyme: http://purl.uniprot.org/enzyme/1.2.1.12
organism: http://purl.uniprot.org/taxonomy/5741
annotation: SIP7050DFFC63A9BD4B
annotation: SIP6536F094DE1145F3
annotation: SIPD46CB691D9C813C6
annotation: SIP5FBEAFE62FC40A4F
annotation: SIP12B4583B834A3C18
annotation: PRO_0000145526
annotation: SIPFD44CE98AAADE62E
annotation: SIP2644775BA2CA5E32
annotation: SIP95BF7CE71E566118
annotation: SIP784BD13E479B95D3
annotation: SIP12E0869CC7C09CA0
annotation: SIPA1B6608AD26970EC
annotation: SIPE6E07E479E111457
annotation: SIPBE516BB85BCFE538
annotation: SIPB7A879082A8280C8
annotation: SIP4066ED4C2EEFE53E
annotation: SIP6F01F021D2F287F1
annotation: SIPD9BA58E053A43763
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/324
classified with: http://purl.uniprot.org/keywords/520
classified with: http://purl.uniprot.org/keywords/560
classified with: GO_0005737
classified with: GO_0004365
classified with: GO_0051287
classified with: GO_0050661
classified with: GO_0006006
classified with: GO_0006096
sequence: P53429-1

SIP8FAECCFD7EC6EE84
type: Submission Citation
author: Rozario C.
author: Smith M.W.
author: Muller M.
date: 1992-03
submitted to: EMBL/GenBank/DDBJ

P53429-citation-SIP8FAECCFD7EC6EE84
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

ATCC 30957 / WB
type: Strain

SIPA93BEAEC77A42C50
type: Submission Citation
author: Smith M.W.
author: Doolittle R.F.
date: 1992-03
submitted to: EMBL/GenBank/DDBJ

P53429-citation-SIPA93BEAEC77A42C50
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 14-312

KOG0657
type: Resource
database: eggNOG
comment: Eukaryota

IPR020831
type: Resource
database: InterPro
comment: GlycerAld/Erythrose_P_DH

IPR020830
type: Resource
database: InterPro
comment: GlycerAld_3-P_DH_AS

IPR020829
type: Resource
database: InterPro
comment: GlycerAld_3-P_DH_cat

IPR020828
type: Resource
database: InterPro
comment: GlycerAld_3-P_DH_NAD(P)-bd

IPR006424
type: Resource
database: InterPro
comment: Glyceraldehyde-3-P_DH_1

TIGR01534
type: Resource
database: NCBIfam
comment: GAPDH-I
signature sequence match: NCBIfam TIGR01534 match 1

PTHR10836
type: Resource
database: PANTHER
comment: GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE
signature sequence match: PANTHER PTHR10836 match 1

PTHR10836:SF76
type: Resource
database: PANTHER
comment: GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED
signature sequence match: PANTHER PTHR10836:SF76 match 1

PF02800
type: Resource
database: Pfam
comment: Gp_dh_C
signature sequence match: Pfam PF02800 match 1

PF00044
type: Resource
database: Pfam
comment: Gp_dh_N
signature sequence match: Pfam PF00044 match 1

PIRSF000149
type: Resource
database: PIRSF
comment: GAP_DH
signature sequence match: PIRSF PIRSF000149 match 1

PR00078
type: Resource
database: PRINTS
comment: G3PDHDRGNASE

SM00846
type: Resource
database: SMART
comment: Gp_dh_N
signature sequence match: SMART SM00846 match 1

SSF55347
type: Resource
database: SUPFAM
comment: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
signature sequence match: SUPFAM SSF55347 match 1

PS00071
type: Resource
database: PROSITE
comment: GAPDH
signature sequence match: PROSITE PS00071 match 1

SIP2440615DD4268354
type: Structured Name
full name: Glyceraldehyde-3-phosphate dehydrogenase 1
short name: GAPDH
ec name: 1.2.1.12

GAP1
type: Gene

SIPD46CB691D9C813C6
type: Subunit Annotation
comment: Homotetramer.

SIP12B4583B834A3C18
type: Similarity Annotation
comment: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

PRO_0000145526
type: Chain Annotation
comment: Glyceraldehyde-3-phosphate dehydrogenase 1
mass: 36450
range: 22576492172163374tt1tt337

22576492172163374tt1
type: Position
type: ExactPosition
position: 1
reference: P53429-1

22576492172163374tt337
type: Position
type: ExactPosition
position: 337
reference: P53429-1

SIPFD44CE98AAADE62E
type: Active Site Annotation
comment: Nucleophile
range: 22576492172163374tt152tt152

22576492172163374tt152
type: Position
type: ExactPosition
position: 152
reference: P53429-1

22576492172163374tt12
type: Position
type: ExactPosition
position: 12
reference: P53429-1

22576492172163374tt13
type: Position
type: ExactPosition
position: 13
reference: P53429-1

22576492172163374tt34
type: Position
type: ExactPosition
position: 34
reference: P53429-1

22576492172163374tt79
type: Position
type: ExactPosition
position: 79
reference: P53429-1

22576492172163374tt151
type: Position
type: ExactPosition
position: 151
reference: P53429-1

22576492172163374tt153
type: Position
type: ExactPosition
position: 153
reference: P53429-1

22576492172163374tt182
type: Position
type: ExactPosition
position: 182
reference: P53429-1

22576492172163374tt211
type: Position
type: ExactPosition
position: 211
reference: P53429-1

22576492172163374tt212
type: Position
type: ExactPosition
position: 212
reference: P53429-1

22576492172163374tt234
type: Position
type: ExactPosition
position: 234
reference: P53429-1

22576492172163374tt316
type: Position
type: ExactPosition
position: 316
reference: P53429-1

SIP4066ED4C2EEFE53E
type: Site Annotation
comment: Activates thiol group during catalysis
range: 22576492172163374tt179tt179

22576492172163374tt179
type: Position
type: ExactPosition
position: 179
reference: P53429-1

SIP6F01F021D2F287F1
type: Natural Variant Annotation
comment: In strain: ATCC 30957 / WB.
substitution: P
range: 22576492172163374tt214tt214

22576492172163374tt214
type: Position
type: ExactPosition
position: 214
reference: P53429-1

SIPD9BA58E053A43763
type: Natural Variant Annotation
comment: In strain: ATCC 30957 / WB.
substitution: K
range: 22576492172163374tt268tt268

22576492172163374tt268
type: Position
type: ExactPosition
position: 268
reference: P53429-1

P53429-1
type: Simple Sequence
modified: 1996-10-01
version: 1
mass: 36450
value: MPIRLGINGFGRIGRMALRASLNIDGVQVVAINDPFTDCEYMEYMLKYDTVHGRFDGTIAHSEDSITVNGNKISVFKSMKPEEIPWGKTQVDIVLECTGRFTTKKDAELHITGGCKRVIISAPSADAPMFVCGCNLETYDPSTMKVISNASCTTNCLAPLAMVVNKKFGIKEGLMTTVHAVTATQLPVDGPSKKDWRGGRSCGANVIPSSTGAAKAVGKVLPALNGKLTGMAFRVPVPDVSVVDLTCTLEKDATYDEICAEIKRGSENELKGIMTYTNEDVVSSDFLSTTSTCNFDSKAGIMLNSRFVKLVAWYDNEFGYANKLVELAKYVGSKGCQ

http://purl.uniprot.org/uniprot/P53429#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/P53429#attribution-ED2E7CA07DBDFB33B999650A3D28C27B
manual: true
evidence: ECO_0000255
source: PRU10009

http://purl.uniprot.org/uniprot/P53429#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

P17063
type: Protein
reviewed: true
created: 1990-08-01
modified: 2023-06-28
version: 102
mnemonic: GIA1_GIAIN
old mnemonic: GIA1_GIALA
old mnemonic: GIAA_GIALA
citation: http://purl.uniprot.org/citations/2808530
citation: http://purl.uniprot.org/citations/1542319
recommended name: SIPEE1AE1E0AA0B5BD2
organism: http://purl.uniprot.org/taxonomy/5741
annotation: SIPFDC982B6F4ADD36C
annotation: SIP29AD78A34412B728
annotation: SIPF9D9BAC72C15493D
annotation: PRO_0000067522
annotation: SIP00BFC7347DA149E1
annotation: SIPCECED4FA48408F1E
annotation: SIPFB0AEEE793717C40
annotation: SIP0337D492CA09ABBF
annotation: SIP95B6106D13933CBB
annotation: SIP18B9B517FB72E1BF
annotation: SIP64C34E5C51FBD24C
annotation: SIPC7BCB84DDF10AB55
annotation: SIP01FEE277552D7BBD
annotation: SIP49719CAA27BB8402
annotation: SIP0581252BC4E4AC1C
annotation: SIP132A49ACA2201AFE
annotation: SIPC80715266F07D4AE
annotation: SIP3A99DA5E36B687CF
annotation: SIP4343CAB5D425D273
annotation: SIP1BACE4EA42ED7E2F
annotation: SIPF0BA8E700C122F14
annotation: SIP17942E3D1AE37DDA
annotation: SIPEA095EA0EF64513C
annotation: SIPC70B10C57ED0B295
annotation: SIPB178B0220A07EFC2
annotation: SIPBEF08B483D6ACB94
annotation: SIPD7A3BAE0AC2305F5
annotation: SIP8A9C237555F837FC
annotation: SIP2494BAC119D3860E
annotation: SIP9F073A86814707CC
annotation: SIP71D813B23B15F3EE
annotation: SIPA964D5EC289B6007
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/41
classified with: http://purl.uniprot.org/keywords/206
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/493
classified with: http://purl.uniprot.org/keywords/677
classified with: GO_0005737
classified with: GO_0005874
classified with: GO_0005509
classified with: GO_0005544
classified with: GO_0007010
sequence: P17063-1

P17063-citation-2808530
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: PROTEIN SEQUENCE OF 3-31

Portland-1
type: Strain

P17063-citation-1542319
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

4EVF
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 1.90
chain sequence mapping: PDB 4EVF tt1tt295

PDB 4EVF tt1tt295
chain: A=1-295

4EVH
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.60
chain sequence mapping: PDB 4EVH tt1tt295

PDB 4EVH tt1tt295
chain: A=1-295

IPR008088
type: Resource
database: InterPro
comment: Alpha_giardin

PR01712
type: Resource
database: PRINTS
comment: ALPHAGIARDIN

SIPEE1AE1E0AA0B5BD2
type: Structured Name
full name: Giardin subunit alpha-1

SIPFDC982B6F4ADD36C
type: Function Annotation
comment: Giardins are involved in parasite attachment to the intestinal mucosa and in the cytoskeletal disassembly and reassembly that marks the transition from infectious trophozoite to transmissible cyst. They may interact with other cytoskeletal proteins such as microtubules in the microribbons or crossbridges, to maintain the integrity of the ventral disk.

SIP29AD78A34412B728
type: Subcellular Location Annotation
comment: Most likely in the edges of the ventral disk microribbons.
located in: SIPCA3EFF6927324386

SIPF9D9BAC72C15493D
type: Similarity Annotation
comment: Belongs to the annexin family. Giardin subunit alpha subfamily.

PRO_0000067522
type: Chain Annotation
comment: Giardin subunit alpha-1
mass: 33890
range: 22572111238673198tt1tt295

22572111238673198tt1
type: Position
type: ExactPosition
position: 1
reference: P17063-1

22572111238673198tt295
type: Position
type: ExactPosition
position: 295
reference: P17063-1

SIP00BFC7347DA149E1
type: Repeat Annotation
comment: Annexin 1
range: 22572111238673198tt2tt71

22572111238673198tt2
type: Position
type: ExactPosition
position: 2
reference: P17063-1

22572111238673198tt71
type: Position
type: ExactPosition
position: 71
reference: P17063-1

SIPCECED4FA48408F1E
type: Repeat Annotation
comment: Annexin 2
range: 22572111238673198tt73tt143

22572111238673198tt73
type: Position
type: ExactPosition
position: 73
reference: P17063-1

22572111238673198tt143
type: Position
type: ExactPosition
position: 143
reference: P17063-1

SIPFB0AEEE793717C40
type: Repeat Annotation
comment: Annexin 3
range: 22572111238673198tt153tt223

22572111238673198tt153
type: Position
type: ExactPosition
position: 153
reference: P17063-1

22572111238673198tt223
type: Position
type: ExactPosition
position: 223
reference: P17063-1

SIP0337D492CA09ABBF
type: Repeat Annotation
comment: Annexin 4
range: 22572111238673198tt226tt293

22572111238673198tt226
type: Position
type: ExactPosition
position: 226
reference: P17063-1

22572111238673198tt293
type: Position
type: ExactPosition
position: 293
reference: P17063-1

22572111238673198tt4
type: Position
type: ExactPosition
position: 4
reference: P17063-1

22572111238673198tt16
type: Position
type: ExactPosition
position: 16
reference: P17063-1

22572111238673198tt20
type: Position
type: ExactPosition
position: 20
reference: P17063-1

22572111238673198tt28
type: Position
type: ExactPosition
position: 28
reference: P17063-1

22572111238673198tt32
type: Position
type: ExactPosition
position: 32
reference: P17063-1

22572111238673198tt46
type: Position
type: ExactPosition
position: 46
reference: P17063-1

22572111238673198tt50
type: Position
type: ExactPosition
position: 50
reference: P17063-1

22572111238673198tt57
type: Position
type: ExactPosition
position: 57
reference: P17063-1

22572111238673198tt62
type: Position
type: ExactPosition
position: 62
reference: P17063-1

22572111238673198tt70
type: Position
type: ExactPosition
position: 70
reference: P17063-1

22572111238673198tt74
type: Position
type: ExactPosition
position: 74
reference: P17063-1

22572111238673198tt87
type: Position
type: ExactPosition
position: 87
reference: P17063-1

22572111238673198tt92
type: Position
type: ExactPosition
position: 92
reference: P17063-1

22572111238673198tt99
type: Position
type: ExactPosition
position: 99
reference: P17063-1

22572111238673198tt104
type: Position
type: ExactPosition
position: 104
reference: P17063-1

22572111238673198tt118
type: Position
type: ExactPosition
position: 118
reference: P17063-1

22572111238673198tt122
type: Position
type: ExactPosition
position: 122
reference: P17063-1

22572111238673198tt130
type: Position
type: ExactPosition
position: 130
reference: P17063-1

22572111238673198tt132
type: Position
type: ExactPosition
position: 132
reference: P17063-1

22572111238673198tt134
type: Position
type: ExactPosition
position: 134
reference: P17063-1

22572111238673198tt135
type: Position
type: ExactPosition
position: 135
reference: P17063-1

22572111238673198tt145
type: Position
type: ExactPosition
position: 145
reference: P17063-1

22572111238673198tt155
type: Position
type: ExactPosition
position: 155
reference: P17063-1

22572111238673198tt167
type: Position
type: ExactPosition
position: 167
reference: P17063-1

22572111238673198tt171
type: Position
type: ExactPosition
position: 171
reference: P17063-1

22572111238673198tt180
type: Position
type: ExactPosition
position: 180
reference: P17063-1

22572111238673198tt183
type: Position
type: ExactPosition
position: 183
reference: P17063-1

22572111238673198tt196
type: Position
type: ExactPosition
position: 196
reference: P17063-1

22572111238673198tt197
type: Position
type: ExactPosition
position: 197
reference: P17063-1

22572111238673198tt199
type: Position
type: ExactPosition
position: 199
reference: P17063-1

22572111238673198tt201
type: Position
type: ExactPosition
position: 201
reference: P17063-1

22572111238673198tt208
type: Position
type: ExactPosition
position: 208
reference: P17063-1

22572111238673198tt211
type: Position
type: ExactPosition
position: 211
reference: P17063-1

22572111238673198tt225
type: Position
type: ExactPosition
position: 225
reference: P17063-1

22572111238673198tt227
type: Position
type: ExactPosition
position: 227
reference: P17063-1

22572111238673198tt240
type: Position
type: ExactPosition
position: 240
reference: P17063-1

22572111238673198tt245
type: Position
type: ExactPosition
position: 245
reference: P17063-1

22572111238673198tt255
type: Position
type: ExactPosition
position: 255
reference: P17063-1

22572111238673198tt256
type: Position
type: ExactPosition
position: 256
reference: P17063-1

22572111238673198tt258
type: Position
type: ExactPosition
position: 258
reference: P17063-1

22572111238673198tt262
type: Position
type: ExactPosition
position: 262
reference: P17063-1

22572111238673198tt265
type: Position
type: ExactPosition
position: 265
reference: P17063-1

22572111238673198tt266
type: Position
type: ExactPosition
position: 266
reference: P17063-1

22572111238673198tt268
type: Position
type: ExactPosition
position: 268
reference: P17063-1

22572111238673198tt272
type: Position
type: ExactPosition
position: 272
reference: P17063-1

22572111238673198tt279
type: Position
type: ExactPosition
position: 279
reference: P17063-1

22572111238673198tt284
type: Position
type: ExactPosition
position: 284
reference: P17063-1

22572111238673198tt292
type: Position
type: ExactPosition
position: 292
reference: P17063-1

P17063-1
type: Simple Sequence
modified: 1990-08-01
version: 1
mass: 33890
value: MPKVTDIANELKQAIDAKDEVQIAFIASEYSAESREKIAKAYVASYGKELPDDIKKALKGGSEESLLMDLFSDRHEVRAQHIRDALSGRNDHMAFFDTVILCTPEDWHETVAAYTRMFKKPLVEDFMKDVGRKEDWCLLMEKWMAHERVSRPGSPEDEAQRLDQAFDQKNTAYLIDFFGTVPSAEYRPIAEAFKAQNGKSIEQAIATIYTKTDYYTFYCAHFALLGMHRLAAYLINCACNDKGDEKRMRRITGMMVDKCLGAKHAYKIYGDMGTDIERCFDKRMAPILRTLWRVK

http://purl.uniprot.org/uniprot/P17063#attribution-4604434B404AEEB73BB04DA731D8FF52
manual: true
evidence: ECO_0000255
source: PRU01245

P19389
type: Protein
reviewed: true
created: 1990-11-01
modified: 2023-06-28
version: 93
mnemonic: GIA2_GIAIN
old mnemonic: GIA2_GIALA
citation: http://purl.uniprot.org/citations/1542319
recommended name: SIPA23A7BE38AB29C09
organism: http://purl.uniprot.org/taxonomy/5741
annotation: SIP711392B8F33A94E4
annotation: SIPBF1B6F3C06A7FD33
annotation: SIPFF4974188CC2E694
annotation: PRO_0000067523
annotation: SIP3018D915F70C25D1
annotation: SIP9C60EEB5DE6D451B
annotation: SIP5E7B9D4CB5353EF6
annotation: SIP5F197022BD7FB386
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/41
classified with: http://purl.uniprot.org/keywords/206
classified with: http://purl.uniprot.org/keywords/493
classified with: http://purl.uniprot.org/keywords/677
classified with: GO_0005737
classified with: GO_0005874
classified with: GO_0005509
classified with: GO_0005544
classified with: GO_0007010
sequence: P19389-1

P19389-citation-1542319
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

Portland-1
type: Strain

SIPA23A7BE38AB29C09
type: Structured Name
full name: Giardin subunit alpha-2

SIP711392B8F33A94E4
type: Function Annotation
comment: Giardins are involved in parasite attachment to the intestinal mucosa and in the cytoskeletal disassembly and reassembly that marks the transition from infectious trophozoite to transmissible cyst. They may interact with other cytoskeletal proteins such as microtubules in the microribbons or crossbridges, to maintain the integrity of the ventral disk.

SIPBF1B6F3C06A7FD33
type: Subcellular Location Annotation
comment: Most likely in the edges of the ventral disk microribbons.
located in: SIPCA3EFF6927324386

SIPFF4974188CC2E694
type: Similarity Annotation
comment: Belongs to the annexin family. Giardin subunit alpha subfamily.

PRO_0000067523
type: Chain Annotation
comment: Giardin subunit alpha-2
mass: 33936
range: 22572119879072046tt1tt296

22572119879072046tt1
type: Position
type: ExactPosition
position: 1
reference: P19389-1

22572119879072046tt296
type: Position
type: ExactPosition
position: 296
reference: P19389-1

SIP3018D915F70C25D1
type: Repeat Annotation
comment: Annexin 1
range: 22572119879072046tt2tt71

22572119879072046tt2
type: Position
type: ExactPosition
position: 2
reference: P19389-1

22572119879072046tt71
type: Position
type: ExactPosition
position: 71
reference: P19389-1

SIP9C60EEB5DE6D451B
type: Repeat Annotation
comment: Annexin 2
range: 22572119879072046tt73tt143

22572119879072046tt73
type: Position
type: ExactPosition
position: 73
reference: P19389-1

22572119879072046tt143
type: Position
type: ExactPosition
position: 143
reference: P19389-1

SIP5E7B9D4CB5353EF6
type: Repeat Annotation
comment: Annexin 3
range: 22572119879072046tt153tt223

22572119879072046tt153
type: Position
type: ExactPosition
position: 153
reference: P19389-1

22572119879072046tt223
type: Position
type: ExactPosition
position: 223
reference: P19389-1

SIP5F197022BD7FB386
type: Repeat Annotation
comment: Annexin 4
range: 22572119879072046tt226tt293

22572119879072046tt226
type: Position
type: ExactPosition
position: 226
reference: P19389-1

22572119879072046tt293
type: Position
type: ExactPosition
position: 293
reference: P19389-1

P19389-1
type: Simple Sequence
modified: 1990-11-01
version: 1
mass: 33936
value: MPKLSQIVADMKQAIDAKDEAQIAFIASEYSADARQRIAQGYRDQYGKELPDDIKKALKGGSEESLLMDLFSDRHEVRAQHIRDALSGKNDHMAFFDTVILCTPEDWHETVAAYTRMFKKPLVEDFMKDVGRKENWCLFMEKWMAHERTSREGSPDEEAEKLNKAFSESDHDYISSFMAGVPPEEYKSINTSFKSLTGKGIDQAFATIYTGTDYYSLYCAHFALLGMHKLAAYLVNCACNDKGDEKRMRRITGMMVDKCLAAKYAYKTYGSMKADVERCFDKRMAPILCTLWRLRE

http://purl.uniprot.org/uniprot/P19389#attribution-4604434B404AEEB73BB04DA731D8FF52
manual: true
evidence: ECO_0000255
source: PRU01245

Q4VPP7
type: Protein
reviewed: true
created: 2007-05-29
modified: 2023-06-28
version: 51
mnemonic: GIA3_GIAIN
old mnemonic: GIA3_GIALA
citation: http://purl.uniprot.org/citations/15862575
recommended name: SIPD6868C8C41E9AAF0
organism: http://purl.uniprot.org/taxonomy/5741
annotation: SIPAAFC20A0958BD676
annotation: SIP6DF939E8AB4975F1
annotation: SIP29400C9AE2338A6C
annotation: PRO_0000288026
annotation: SIP7D35EE6E1A0D71AE
annotation: SIP8FDA06CC43372AB0
annotation: SIPCC89BAACC22BB786
annotation: SIP565BA039D21E26FD
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/41
classified with: http://purl.uniprot.org/keywords/206
classified with: http://purl.uniprot.org/keywords/493
classified with: http://purl.uniprot.org/keywords/677
classified with: GO_0005737
classified with: GO_0005874
classified with: GO_0005509
classified with: GO_0005544
classified with: GO_0007010
sequence: Q4VPP7-1

Q4VPP7-citation-15862575
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

ATCC 50803 / WB-C6
type: Strain

SIPD6868C8C41E9AAF0
type: Structured Name
full name: Giardin subunit alpha-3

SIPAAFC20A0958BD676
type: Function Annotation
comment: Giardins are involved in parasite attachment to the intestinal mucosa and in the cytoskeletal disassembly and reassembly that marks the transition from infectious trophozoite to transmissible cyst. They may interact with other cytoskeletal proteins such as microtubules in the microribbons or crossbridges, to maintain the integrity of the ventral disk (By similarity).

SIP29400C9AE2338A6C
type: Similarity Annotation
comment: Belongs to the annexin family. Giardin subunit alpha subfamily.

PRO_0000288026
type: Chain Annotation
comment: Giardin subunit alpha-3
mass: 33320
range: 22857018432829230tt1tt296

22857018432829230tt1
type: Position
type: ExactPosition
position: 1
reference: Q4VPP7-1

22857018432829230tt296
type: Position
type: ExactPosition
position: 296
reference: Q4VPP7-1

SIP7D35EE6E1A0D71AE
type: Repeat Annotation
comment: Annexin 1
range: 22857018432829230tt3tt72

22857018432829230tt3
type: Position
type: ExactPosition
position: 3
reference: Q4VPP7-1

22857018432829230tt72
type: Position
type: ExactPosition
position: 72
reference: Q4VPP7-1

SIP8FDA06CC43372AB0
type: Repeat Annotation
comment: Annexin 2
range: 22857018432829230tt74tt146

22857018432829230tt74
type: Position
type: ExactPosition
position: 74
reference: Q4VPP7-1

22857018432829230tt146
type: Position
type: ExactPosition
position: 146
reference: Q4VPP7-1

SIPCC89BAACC22BB786
type: Repeat Annotation
comment: Annexin 3
range: 22857018432829230tt153tt222

22857018432829230tt153
type: Position
type: ExactPosition
position: 153
reference: Q4VPP7-1

22857018432829230tt222
type: Position
type: ExactPosition
position: 222
reference: Q4VPP7-1

SIP565BA039D21E26FD
type: Repeat Annotation
comment: Annexin 4
range: 22857018432829230tt226tt295

22857018432829230tt226
type: Position
type: ExactPosition
position: 226
reference: Q4VPP7-1

22857018432829230tt295
type: Position
type: ExactPosition
position: 295
reference: Q4VPP7-1

Q4VPP7-1
type: Simple Sequence
modified: 2005-07-05
version: 1
mass: 33320
value: MSDTVTKVVADLNAAILQKSARAIAEVACKYSASDREKVRAQYRSTYSIEPDDHINKMLKGGDAATIVSNCWDELPVLRAKHLSKALKGSVDHRALLDLLIMCDREDWNNTVVAFTQQFRKNLPEELEKALKSTTSYRAFYTTWIKFDRAPRNNINGDALKLKEAFSKKDEQTVFDIMSTTVESEYKAIATQFEKVAGMTMIQAFAALTSGPLYWALHTAHYRNIGMNNGAAFLIHHACTADKKGDIARMTRLSPLLCDKCLNAKNYYSEFGDMGKDIVNAFKDAVEEVLKVLWRV

http://purl.uniprot.org/uniprot/Q4VPP7#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/Q4VPP7#attribution-4604434B404AEEB73BB04DA731D8FF52
manual: true
evidence: ECO_0000255
source: PRU01245

Q4VPQ3
type: Protein
reviewed: true
created: 2007-05-29
modified: 2023-06-28
version: 54
mnemonic: GIA4_GIAIN
old mnemonic: GIA4_GIALA
citation: http://purl.uniprot.org/citations/15862575
recommended name: SIPC6111F8A2C62DC40
organism: http://purl.uniprot.org/taxonomy/5741
annotation: SIP9FA596DD4132968D
annotation: SIP4248433132ADB119
annotation: SIP9E12D5CD896E17DF
annotation: PRO_0000288027
annotation: SIP095560E08F5891D5
annotation: SIPD5147F3D5355AE8D
annotation: SIP74B90F7C29A18916
annotation: SIP7891ED30443E9690
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/41
classified with: http://purl.uniprot.org/keywords/206
classified with: http://purl.uniprot.org/keywords/493
classified with: http://purl.uniprot.org/keywords/677
classified with: GO_0005737
classified with: GO_0005874
classified with: GO_0005509
classified with: GO_0005544
classified with: GO_0007010
sequence: Q4VPQ3-1

Q4VPQ3-citation-15862575
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

ATCC 50803 / WB-C6
type: Strain

SIPC6111F8A2C62DC40
type: Structured Name
full name: Giardin subunit alpha-4

SIP9FA596DD4132968D
type: Function Annotation
comment: Giardins are involved in parasite attachment to the intestinal mucosa and in the cytoskeletal disassembly and reassembly that marks the transition from infectious trophozoite to transmissible cyst. They may interact with other cytoskeletal proteins such as microtubules in the microribbons or crossbridges, to maintain the integrity of the ventral disk (By similarity).

SIP9E12D5CD896E17DF
type: Similarity Annotation
comment: Belongs to the annexin family. Giardin subunit alpha subfamily.

PRO_0000288027
type: Chain Annotation
comment: Giardin subunit alpha-4
mass: 33614
range: 22857018432893742tt1tt296

22857018432893742tt1
type: Position
type: ExactPosition
position: 1
reference: Q4VPQ3-1

22857018432893742tt296
type: Position
type: ExactPosition
position: 296
reference: Q4VPQ3-1

SIP095560E08F5891D5
type: Repeat Annotation
comment: Annexin 1
range: 22857018432893742tt3tt72

22857018432893742tt3
type: Position
type: ExactPosition
position: 3
reference: Q4VPQ3-1

22857018432893742tt72
type: Position
type: ExactPosition
position: 72
reference: Q4VPQ3-1

SIPD5147F3D5355AE8D
type: Repeat Annotation
comment: Annexin 2
range: 22857018432893742tt74tt146

22857018432893742tt74
type: Position
type: ExactPosition
position: 74
reference: Q4VPQ3-1

22857018432893742tt146
type: Position
type: ExactPosition
position: 146
reference: Q4VPQ3-1

SIP74B90F7C29A18916
type: Repeat Annotation
comment: Annexin 3
range: 22857018432893742tt153tt223

22857018432893742tt153
type: Position
type: ExactPosition
position: 153
reference: Q4VPQ3-1

22857018432893742tt223
type: Position
type: ExactPosition
position: 223
reference: Q4VPQ3-1

SIP7891ED30443E9690
type: Repeat Annotation
comment: Annexin 4
range: 22857018432893742tt226tt294

22857018432893742tt226
type: Position
type: ExactPosition
position: 226
reference: Q4VPQ3-1

22857018432893742tt294
type: Position
type: ExactPosition
position: 294
reference: Q4VPQ3-1

Q4VPQ3-1
type: Simple Sequence
modified: 2005-07-05
version: 1
mass: 33614
value: MSATVSTVSADLHKAIDAGDEDKITKITASYGSEQRDKIIPAYHANYGIPPSEAIRKAFKTGFYETMIVHAWTSRFELRAKLIHESIKGKIDVITLLDLVIACMPDDWYGTKVCYTKLYGRELVREIDEVIGVGTPWQSLVSGWVKHDRKYRKSIKSDAEAFRMALDSDNYEVLGSMLATSVPDEWMRIAAAYEETTGMPIDQAIASRYVKVDQTALILAHHWLCDPGQAAAYICSQCCAERKGNYARICRFTSMMYDHCLKCKYAYRAYGSLAMDIRKCFEPKLAKHLLVFWRVE

http://purl.uniprot.org/uniprot/Q4VPQ3#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/Q4VPQ3#attribution-4604434B404AEEB73BB04DA731D8FF52
manual: true
evidence: ECO_0000255
source: PRU01245

Q4VPQ4
type: Protein
reviewed: true
created: 2007-05-29
modified: 2023-06-28
version: 56
mnemonic: GIA5_GIAIN
old mnemonic: GIA5_GIALA
citation: http://purl.uniprot.org/citations/15862575
recommended name: SIP23C070699F7F41B5
organism: http://purl.uniprot.org/taxonomy/5741
annotation: SIP55F90A4368AB608D
annotation: SIP73D32ABB8DEF8435
annotation: SIP69BAF7D440891228
annotation: PRO_0000288028
annotation: SIP50020B7182191869
annotation: SIP74BDB4A78B9EB474
annotation: SIP3F0491E2858889B9
annotation: SIPBEC8F00111630E4E
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/41
classified with: http://purl.uniprot.org/keywords/206
classified with: http://purl.uniprot.org/keywords/493
classified with: http://purl.uniprot.org/keywords/677
classified with: GO_0005737
classified with: GO_0005874
classified with: GO_0005509
classified with: GO_0005544
classified with: GO_0007010
sequence: Q4VPQ4-1

Q4VPQ4-citation-15862575
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

ATCC 50803 / WB-C6
type: Strain

SIP23C070699F7F41B5
type: Structured Name
full name: Giardin subunit alpha-5

SIP55F90A4368AB608D
type: Function Annotation
comment: Giardins are involved in parasite attachment to the intestinal mucosa and in the cytoskeletal disassembly and reassembly that marks the transition from infectious trophozoite to transmissible cyst. They may interact with other cytoskeletal proteins such as microtubules in the microribbons or crossbridges, to maintain the integrity of the ventral disk (By similarity).

SIP69BAF7D440891228
type: Similarity Annotation
comment: Belongs to the annexin family. Giardin subunit alpha subfamily.

PRO_0000288028
type: Chain Annotation
comment: Giardin subunit alpha-5
mass: 33921
range: 22857018432893998tt1tt302

22857018432893998tt1
type: Position
type: ExactPosition
position: 1
reference: Q4VPQ4-1

22857018432893998tt302
type: Position
type: ExactPosition
position: 302
reference: Q4VPQ4-1

SIP50020B7182191869
type: Repeat Annotation
comment: Annexin 1
range: 22857018432893998tt1tt72

22857018432893998tt72
type: Position
type: ExactPosition
position: 72
reference: Q4VPQ4-1

SIP74BDB4A78B9EB474
type: Repeat Annotation
comment: Annexin 2
range: 22857018432893998tt74tt144

22857018432893998tt74
type: Position
type: ExactPosition
position: 74
reference: Q4VPQ4-1

22857018432893998tt144
type: Position
type: ExactPosition
position: 144
reference: Q4VPQ4-1

SIP3F0491E2858889B9
type: Repeat Annotation
comment: Annexin 3
range: 22857018432893998tt153tt226

22857018432893998tt153
type: Position
type: ExactPosition
position: 153
reference: Q4VPQ4-1

22857018432893998tt226
type: Position
type: ExactPosition
position: 226
reference: Q4VPQ4-1

SIPBEC8F00111630E4E
type: Repeat Annotation
comment: Annexin 4
range: 22857018432893998tt230tt298

22857018432893998tt230
type: Position
type: ExactPosition
position: 230
reference: Q4VPQ4-1

22857018432893998tt298
type: Position
type: ExactPosition
position: 298
reference: Q4VPQ4-1

Q4VPQ4-1
type: Simple Sequence
modified: 2005-07-05
version: 1
mass: 33921
value: MTSTVAQICSDLKGAIDKKDELRIAFIASEYSSPSRLKIAQSYEATYKTPITEAIKKSLKGGTAEDLLVNMWVSRHEHRAELINKALGGSSDEEAIRELVFLCNPEDWHETASVYNQKYQKIMQDAVTKAIGSKSHWAKLVAGWMEHKREDRGSVENDVKYLKELIDAPVTDGNALAQFFASTTPDEYTQIADKFCEEYNLSIDQALVRPLKENEDDLEAYAAAHFALHGLPVLAAQLINKACRPKNGNERSICRITTLMVDQCLAAKYAYKLYGDMGADLSRCFDERMAPILRTLWRVTDA

http://purl.uniprot.org/uniprot/Q4VPQ4#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/Q4VPQ4#attribution-4604434B404AEEB73BB04DA731D8FF52
manual: true
evidence: ECO_0000255
source: PRU01245

Q4VPP5
type: Protein
reviewed: true
created: 2007-05-29
modified: 2023-06-28
version: 51
mnemonic: GIA6_GIAIN
old mnemonic: GIA6_GIALA
citation: http://purl.uniprot.org/citations/15862575
recommended name: SIPB9AE307ED9296985
organism: http://purl.uniprot.org/taxonomy/5741
annotation: SIPC8F2BC420C190822
annotation: SIPB5654FB1122283AB
annotation: SIP1EF2FFE2105DD682
annotation: PRO_0000288029
annotation: SIP5A5FD72B90262797
annotation: SIP19D197C4291A4D06
annotation: SIP14B9FCA5E7C9CAC2
annotation: SIPCCD09D78B1AD6A97
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/41
classified with: http://purl.uniprot.org/keywords/206
classified with: http://purl.uniprot.org/keywords/493
classified with: http://purl.uniprot.org/keywords/677
classified with: GO_0005737
classified with: GO_0005874
classified with: GO_0005509
classified with: GO_0005544
classified with: GO_0007010
sequence: Q4VPP5-1

Q4VPP5-citation-15862575
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

ATCC 50803 / WB-C6
type: Strain

SIPB9AE307ED9296985
type: Structured Name
full name: Giardin subunit alpha-6

SIPC8F2BC420C190822
type: Function Annotation
comment: Giardins are involved in parasite attachment to the intestinal mucosa and in the cytoskeletal disassembly and reassembly that marks the transition from infectious trophozoite to transmissible cyst. They may interact with other cytoskeletal proteins such as microtubules in the microribbons or crossbridges, to maintain the integrity of the ventral disk (By similarity).

SIP1EF2FFE2105DD682
type: Similarity Annotation
comment: Belongs to the annexin family. Giardin subunit alpha subfamily.

PRO_0000288029
type: Chain Annotation
comment: Giardin subunit alpha-6
mass: 33148
range: 22857018432828718tt1tt297

22857018432828718tt1
type: Position
type: ExactPosition
position: 1
reference: Q4VPP5-1

22857018432828718tt297
type: Position
type: ExactPosition
position: 297
reference: Q4VPP5-1

SIP5A5FD72B90262797
type: Repeat Annotation
comment: Annexin 1
range: 22857018432828718tt3tt72

22857018432828718tt3
type: Position
type: ExactPosition
position: 3
reference: Q4VPP5-1

22857018432828718tt72
type: Position
type: ExactPosition
position: 72
reference: Q4VPP5-1

SIP19D197C4291A4D06
type: Repeat Annotation
comment: Annexin 2
range: 22857018432828718tt74tt146

22857018432828718tt74
type: Position
type: ExactPosition
position: 74
reference: Q4VPP5-1

22857018432828718tt146
type: Position
type: ExactPosition
position: 146
reference: Q4VPP5-1

SIP14B9FCA5E7C9CAC2
type: Repeat Annotation
comment: Annexin 3
range: 22857018432828718tt153tt222

22857018432828718tt153
type: Position
type: ExactPosition
position: 153
reference: Q4VPP5-1

22857018432828718tt222
type: Position
type: ExactPosition
position: 222
reference: Q4VPP5-1

SIPCCD09D78B1AD6A97
type: Repeat Annotation
comment: Annexin 4
range: 22857018432828718tt226tt295

22857018432828718tt226
type: Position
type: ExactPosition
position: 226
reference: Q4VPP5-1

22857018432828718tt295
type: Position
type: ExactPosition
position: 295
reference: Q4VPP5-1

Q4VPP5-1
type: Simple Sequence
modified: 2005-07-05
version: 1
mass: 33148
value: MVTTVQDLAEQLRQAVESSNEQMIAGLASAYSGKEREKVLRAYLSATGTTAADAIRKALKNGPTENLLAYLWDKPGDVRAKLIRNALSGKNDEAALIDLVIHCSSEDWYNTCTEYTTDYKRVLNDDLLSDIGTKEQWTKVFKHWILHKRSDRFDIDGDEKRLVTAIGKKDYDTIAEMLGTTSVSEYANIVRRAEVTLGKTIDQALSAVWSKQDLAVLLAAHYELLHPARLAFHLLKQALDGKKPDEARIIRITALTFDTCLAVKYAASEAGYDIGSAFAKALDKRLAPLIKILWRVM

http://purl.uniprot.org/uniprot/Q4VPP5#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/Q4VPP5#attribution-4604434B404AEEB73BB04DA731D8FF52
manual: true
evidence: ECO_0000255
source: PRU01245

Q4VPP9
type: Protein
reviewed: true
created: 2007-05-29
modified: 2023-06-28
version: 55
mnemonic: GIA8_GIAIN
old mnemonic: GIA8_GIALA
citation: http://purl.uniprot.org/citations/15862575
recommended name: SIPF8863C7D9A3EF7E5
organism: http://purl.uniprot.org/taxonomy/5741
annotation: SIPB34FA5BF13E462A2
annotation: SIP3DA2EDA4E774527F
annotation: SIPA8987A5FD533C6DD
annotation: PRO_0000288030
annotation: SIP19E36D19A000451E
annotation: SIPF2BCAB10A3AA3853
annotation: SIP39A8C71DFAB78B75
annotation: SIP5E92CCFEFB0ED60A
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/41
classified with: http://purl.uniprot.org/keywords/206
classified with: http://purl.uniprot.org/keywords/493
classified with: http://purl.uniprot.org/keywords/677
classified with: GO_0005737
classified with: GO_0005874
classified with: GO_0005509
classified with: GO_0005544
classified with: GO_0007010
sequence: Q4VPP9-1

Q4VPP9-citation-15862575
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

ATCC 50803 / WB-C6
type: Strain

SIPF8863C7D9A3EF7E5
type: Structured Name
full name: Giardin subunit alpha-8

SIPB34FA5BF13E462A2
type: Function Annotation
comment: Giardins are involved in parasite attachment to the intestinal mucosa and in the cytoskeletal disassembly and reassembly that marks the transition from infectious trophozoite to transmissible cyst. They may interact with other cytoskeletal proteins such as microtubules in the microribbons or crossbridges, to maintain the integrity of the ventral disk (By similarity).

SIPA8987A5FD533C6DD
type: Similarity Annotation
comment: Belongs to the annexin family. Giardin subunit alpha subfamily.

PRO_0000288030
type: Chain Annotation
comment: Giardin subunit alpha-8
mass: 35769
range: 22857018432829742tt1tt311

22857018432829742tt1
type: Position
type: ExactPosition
position: 1
reference: Q4VPP9-1

22857018432829742tt311
type: Position
type: ExactPosition
position: 311
reference: Q4VPP9-1

SIP19E36D19A000451E
type: Repeat Annotation
comment: Annexin 1
range: 22857018432829742tt5tt73

22857018432829742tt5
type: Position
type: ExactPosition
position: 5
reference: Q4VPP9-1

22857018432829742tt73
type: Position
type: ExactPosition
position: 73
reference: Q4VPP9-1

SIPF2BCAB10A3AA3853
type: Repeat Annotation
comment: Annexin 2
range: 22857018432829742tt75tt146

22857018432829742tt75
type: Position
type: ExactPosition
position: 75
reference: Q4VPP9-1

22857018432829742tt146
type: Position
type: ExactPosition
position: 146
reference: Q4VPP9-1

SIP39A8C71DFAB78B75
type: Repeat Annotation
comment: Annexin 3
range: 22857018432829742tt154tt223

22857018432829742tt154
type: Position
type: ExactPosition
position: 154
reference: Q4VPP9-1

22857018432829742tt223
type: Position
type: ExactPosition
position: 223
reference: Q4VPP9-1

SIP5E92CCFEFB0ED60A
type: Repeat Annotation
comment: Annexin 4
range: 22857018432829742tt227tt295

22857018432829742tt227
type: Position
type: ExactPosition
position: 227
reference: Q4VPP9-1

22857018432829742tt295
type: Position
type: ExactPosition
position: 295
reference: Q4VPP9-1

Q4VPP9-1
type: Simple Sequence
modified: 2005-07-05
version: 1
mass: 35769
value: MDDSRKAYVVAQDLHNAIMQRDAITISEITGRYVSGYREKIALAFMEQYNVLPADLFKEWGTGYFESLMIRCWTNRHEARAKMLKEAIRGALDRDALVDLVILCSTDDWASTLVHYQKHFRIALKADIRLNMPADRPWKALIDRWMEHDRHYRNNVKTDAHMLLQALEGGNGAAIVDILVTTKPQEWEKIVAAYEEHTNKSLETAICMAFPGFEQTAFCAAHYWLCEPSKAAAFLIHRACEGKRGDFRRVCRITSLVLDQCLKCKYVYSVYGHLAADFRKTFSDNTAIPLISLWRAYDIGKILAEKHENIT

http://purl.uniprot.org/uniprot/Q4VPP9#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/Q4VPP9#attribution-4604434B404AEEB73BB04DA731D8FF52
manual: true
evidence: ECO_0000255
source: PRU01245

Q4VPP0
type: Protein
reviewed: true
created: 2007-05-29
modified: 2023-06-28
version: 54
mnemonic: GIA9_GIAIN
old mnemonic: GIA9_GIALA
citation: http://purl.uniprot.org/citations/15862575
recommended name: SIPC2BBDC40A9C0EDB9
organism: http://purl.uniprot.org/taxonomy/5741
annotation: SIP77CE2884E789BF4A
annotation: SIPBF9F1A95E5CD2C41
annotation: SIP3665711CC2167E24
annotation: PRO_0000288031
annotation: SIPF052F763AF17C138
annotation: SIP07CFB8F7EE4D3431
annotation: SIP5513584933BBC2A8
annotation: SIPEFFB12F252AD9BE8
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/41
classified with: http://purl.uniprot.org/keywords/206
classified with: http://purl.uniprot.org/keywords/493
classified with: http://purl.uniprot.org/keywords/677
classified with: GO_0005737
classified with: GO_0005874
classified with: GO_0005509
classified with: GO_0005544
classified with: GO_0007010
sequence: Q4VPP0-1

Q4VPP0-citation-15862575
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

ATCC 50803 / WB-C6
type: Strain

SIPC2BBDC40A9C0EDB9
type: Structured Name
full name: Giardin subunit alpha-9

SIP77CE2884E789BF4A
type: Function Annotation
comment: Giardins are involved in parasite attachment to the intestinal mucosa and in the cytoskeletal disassembly and reassembly that marks the transition from infectious trophozoite to transmissible cyst. They may interact with other cytoskeletal proteins such as microtubules in the microribbons or crossbridges, to maintain the integrity of the ventral disk (By similarity).

SIP3665711CC2167E24
type: Similarity Annotation
comment: Belongs to the annexin family. Giardin subunit alpha subfamily.

PRO_0000288031
type: Chain Annotation
comment: Giardin subunit alpha-9
mass: 33787
range: 22857018432827438tt1tt301

22857018432827438tt1
type: Position
type: ExactPosition
position: 1
reference: Q4VPP0-1

22857018432827438tt301
type: Position
type: ExactPosition
position: 301
reference: Q4VPP0-1

SIPF052F763AF17C138
type: Repeat Annotation
comment: Annexin 1
range: 22857018432827438tt2tt72

22857018432827438tt2
type: Position
type: ExactPosition
position: 2
reference: Q4VPP0-1

22857018432827438tt72
type: Position
type: ExactPosition
position: 72
reference: Q4VPP0-1

SIP07CFB8F7EE4D3431
type: Repeat Annotation
comment: Annexin 2
range: 22857018432827438tt74tt146

22857018432827438tt74
type: Position
type: ExactPosition
position: 74
reference: Q4VPP0-1

22857018432827438tt146
type: Position
type: ExactPosition
position: 146
reference: Q4VPP0-1

SIP5513584933BBC2A8
type: Repeat Annotation
comment: Annexin 3
range: 22857018432827438tt153tt223

22857018432827438tt153
type: Position
type: ExactPosition
position: 153
reference: Q4VPP0-1

22857018432827438tt223
type: Position
type: ExactPosition
position: 223
reference: Q4VPP0-1

SIPEFFB12F252AD9BE8
type: Repeat Annotation
comment: Annexin 4
range: 22857018432827438tt225tt294

22857018432827438tt225
type: Position
type: ExactPosition
position: 225
reference: Q4VPP0-1

22857018432827438tt294
type: Position
type: ExactPosition
position: 294
reference: Q4VPP0-1

Q4VPP0-1
type: Simple Sequence
modified: 2005-07-05
version: 1
mass: 33787
value: MSLTVSDLTTELKKIIDSKNESALVQLTSQYASKHRDKVVINYKSIYGMYPADAIKKALKSGPAETLLMYAWTDAQEVRARLLNQALSGKNNKSALIDVVLFCGPEDWYEMGAHYTRIFQKVANDTLLSDIGSSEPWSQLIKGWIKHDRYERKAISEDAAALMGYLESGNPDGLIDLLCNTTEGEWKKINKVFTEKYGVEVETLIASNYVKTDMEALLTAHFYLLQPGYAAAYLCSLANSGKKGDSDRMVRITSLMFDKALKCKFAYEKYGKLGSDFKRLYDARLGRALCALWRVDTEGAN

http://purl.uniprot.org/uniprot/Q4VPP0#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/Q4VPP0#attribution-4604434B404AEEB73BB04DA731D8FF52
manual: true
evidence: ECO_0000255
source: PRU01245

P15518
type: Protein
reviewed: true
created: 1990-04-01
modified: 2023-06-28
version: 66
mnemonic: GIAB_GIAIN
old mnemonic: GIAB_GIALA
citation: http://purl.uniprot.org/citations/7659516
citation: http://purl.uniprot.org/citations/3405761
citation: http://purl.uniprot.org/citations/3225852
conflicting sequence: SIPE7087D8545672D0C
conflicting sequence: SIP173109D4A61559AF
recommended name: SIPF17E5CD7D4F3017C
alternative name: SIP8E26AB93424DE951
organism: http://purl.uniprot.org/taxonomy/5741
annotation: SIP0DBCF84AAFCB8EC0
annotation: SIP46AFA4E27127B0F9
annotation: SIP6C6E74E830AB09AF
annotation: SIP282446F5B92EE368
annotation: SIPA65897E79442066D
annotation: SIP8E62B8725E4D235C
annotation: PRO_0000221444
annotation: SIP26B0B82F7101C8C2
annotation: SIP7E003E4599CC8627
annotation: SIP2FE13F3F1D1212D8
annotation: SIP0E076998B0EEE1D9
existence: Evidence at Transcript Level Existence
classified with: http://purl.uniprot.org/keywords/175
classified with: http://purl.uniprot.org/keywords/206
classified with: http://purl.uniprot.org/keywords/493
classified with: GO_0005737
classified with: GO_0005874
classified with: GO_0005200
sequence: P15518-1

P15518-citation-7659516
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: SEQUENCE REVISION TO N-TERMINUS

Portland-1
type: Strain

P15518-citation-3405761
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE

P15518-citation-3225852
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE

EMBL CAA32388.1
comment: Different initiation.

EMBL AAA29154.1
comment: Different initiation.

IPR038835
type: Resource
database: InterPro
comment: Giardin_beta-like

IPR008374
type: Resource
database: InterPro
comment: SF_assemblin/giardin_b

PTHR37027
type: Resource
database: PANTHER
comment: KDE4
signature sequence match: PANTHER PTHR37027 match 1

PTHR37027:SF2
type: Resource
database: PANTHER
comment: KDE4
signature sequence match: PANTHER PTHR37027:SF2 match 1

PF06705
type: Resource
database: Pfam
comment: SF-assemblin
signature sequence match: Pfam PF06705 match 1

PR01799
type: Resource
database: PRINTS
comment: SFASSEMBLIN

SIPF17E5CD7D4F3017C
type: Structured Name
full name: Giardin subunit beta

SIP8E26AB93424DE951
type: Structured Name
full name: Protein 14B, cytoskeletal

SIP0DBCF84AAFCB8EC0
type: Function Annotation
comment: Giardins are involved in parasite attachment to the intestinal mucosa and in the cytoskeletal disassembly and reassembly that marks the transition from infectious trophozoite to transmissible cyst. They may interact with other cytoskeletal proteins such as microtubules in the microribbons or crossbridges, to maintain the integrity of the ventral disk.

SIP46AFA4E27127B0F9
type: Subcellular Location Annotation
comment: Microribbons of ventral disc.
located in: SIPCA3EFF6927324386

SIP6C6E74E830AB09AF
type: Domain Annotation
comment: Shows an alpha-helical coiled coil structure (35 repeating heptads) related to the alpha-type fibrous proteins (K-M-E-F class).

SIP282446F5B92EE368
type: Similarity Annotation
comment: Belongs to the SF-assemblin family.

PRO_0000221444
type: Chain Annotation
comment: Giardin subunit beta
mass: 31005
range: 22572102732298286tt1tt273

22572102732298286tt1
type: Position
type: ExactPosition
position: 1
reference: P15518-1

22572102732298286tt273
type: Position
type: ExactPosition
position: 273
reference: P15518-1

SIP26B0B82F7101C8C2
type: Region Annotation
comment: Nonhelical region
range: 22572102732298286tt1tt19

22572102732298286tt19
type: Position
type: ExactPosition
position: 19
reference: P15518-1

SIP7E003E4599CC8627
type: Region Annotation
comment: Rod
range: 22572102732298286tt20tt273

22572102732298286tt20
type: Position
type: ExactPosition
position: 20
reference: P15518-1

22572102732298286tt123
type: Position
type: ExactPosition
position: 123
reference: P15518-1

22572102732298286tt175
type: Position
type: ExactPosition
position: 175
reference: P15518-1

22572102732298286tt211
type: Position
type: ExactPosition
position: 211
reference: P15518-1

22572102732298286tt263
type: Position
type: ExactPosition
position: 263
reference: P15518-1

P15518-1
type: Simple Sequence
modified: 1997-11-01
version: 2
mass: 31005
value: MSMFTSTRTLTQTMDKPDDLTRSATETAVKLSNMNQRVSRFHDKMENEIEVRRVDDDTRVKMIKDAIAHLDRLIQTESRKRQASFEDIREEVKKSADNMYLTIKEEIDTMAANFRKSLAEMGDTLNNVETNLQNQIAIHNDAIAALRKEALKSLNDLETGIATENAERKKMYDQLNEKVAEGFARISAAIEKETIARERAVSAATTEALTNTKLVEKCVNEQLENVASEIRAIQEEIDREKAERKEAEDKIVNTLEDVVSKIQGGLSMVTKHQ

http://purl.uniprot.org/uniprot/P15518#attribution-DC036A124EC8E88DF072B29F6D9BB9FE
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/P15518#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

P38413
type: Protein
reviewed: true
created: 1994-10-01
modified: 2023-06-28
version: 54
mnemonic: GIAG_GIAIN
old mnemonic: GIAG_GIALA
citation: http://purl.uniprot.org/citations/1474999
recommended name: SIP62639C8DCAD1E9B2
organism: http://purl.uniprot.org/taxonomy/5741
annotation: SIP94FA5CB66E0C6096
annotation: SIP434DA8FA6CBF302F
annotation: PRO_0000087485
annotation: SIPA87905B749D16E62
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/175
classified with: http://purl.uniprot.org/keywords/206
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/493
classified with: GO_0005737
classified with: GO_0005874
sequence: P38413-1

P38413-citation-1474999
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: PROTEIN SEQUENCE OF 145-156

Portland-1
type: Strain

A48453
type: Resource
database: PIR
comment: S25163

SIP62639C8DCAD1E9B2
type: Structured Name
full name: Giardin subunit gamma

SIP94FA5CB66E0C6096
type: Function Annotation
comment: Giardins are involved in parasite attachment to the intestinal mucosa and in the cytoskeletal disassembly and reassembly that marks the transition from infectious trophozoite to transmissible cyst. They may interact with other cytoskeletal proteins such as microtubules in the microribbons or crossbridges, to maintain the integrity of the ventral disk.

SIP434DA8FA6CBF302F
type: Subcellular Location Annotation
comment: Microribbons of ventral disc.
located in: SIPCA3EFF6927324386

PRO_0000087485
type: Chain Annotation
comment: Giardin subunit gamma
mass: 35632
range: 22574314623677230tt1tt311

22574314623677230tt1
type: Position
type: ExactPosition
position: 1
reference: P38413-1

22574314623677230tt311
type: Position
type: ExactPosition
position: 311
reference: P38413-1

22574314623677230tt185
type: Position
type: ExactPosition
position: 185
reference: P38413-1

22574314623677230tt233
type: Position
type: ExactPosition
position: 233
reference: P38413-1

P38413-1
type: Simple Sequence
modified: 1994-10-01
version: 1
mass: 35632
value: MKSSFSTVSSYSDHKFAVKDAPTTIRDSLRLTNAVEDPGYMTLSLISENKVDDLMFNSKMFQDHMVNDFRPKFSHADSSEIMITLNNLKNDILSTKNIRELESTDLRSEVAKQFAARRAELVSHLNASLRPLIDEVFSMEQRLKAFDAENADFVGKTKQYKSTFRSEVHSRIRAGQSKLDALRHGLQTEINSLEAIIEREFAQAANRLNQEVSNFKESFDASERNIKLQKKHVISGMNEKIKSFAESVAKYLPILKKNSEERRFNQMMMQKNLAEIMTVLSDNSEHFGDYCFSDLVPDTRIFDAIMTTKVD

http://purl.uniprot.org/uniprot/P38413#attribution-DC036A124EC8E88DF072B29F6D9BB9FE
manual: true
evidence: ECO_0000255

Q9GTW9
type: Protein
reviewed: true
created: 2002-01-23
modified: 2023-05-03
version: 59
mnemonic: GLK1_TRIVA
citation: http://purl.uniprot.org/citations/11250082
recommended name: SIP6E4599E304BB34B4
alternative name: SIP1D73FCE1447F4C6C
alternative name: SIP8BA23DC52C011156
enzyme: http://purl.uniprot.org/enzyme/2.7.1.2
organism: http://purl.uniprot.org/taxonomy/5722
annotation: SIP14326C2583546B6C
annotation: SIPF2977F7BE452B356
annotation: SIP27ECB264C9DBE9D1
annotation: SIPA6B198AFA2EDE2F5
annotation: PRO_0000215151
annotation: SIP33E1A2A5108F0A0D
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/903
classified with: http://purl.uniprot.org/keywords/324
classified with: http://purl.uniprot.org/keywords/418
classified with: GO_0005524
classified with: GO_0004340
classified with: GO_0005536
classified with: GO_0006096
sequence: Q9GTW9-1

Q9GTW9-citation-11250082
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: PARTIAL PROTEIN SEQUENCE
scope: CHARACTERIZATION

ATCC 30001 / NIH-C1
type: Strain

ENOG502S3Y5
type: Resource
database: eggNOG
comment: Eukaryota

IPR003836
type: Resource
database: InterPro
comment: Glucokinase

PTHR47450
type: Resource
database: PANTHER
comment: GLUCOKINASE
signature sequence match: PANTHER PTHR47450 match 1

PTHR47450:SF1
type: Resource
database: PANTHER
comment: GLUCOKINASE
signature sequence match: PANTHER PTHR47450:SF1 match 1

PF02685
type: Resource
database: Pfam
comment: Glucokinase
signature sequence match: Pfam PF02685 match 1

SIP6E4599E304BB34B4
type: Structured Name
full name: Glucokinase 1
ec name: 2.7.1.2

SIP1D73FCE1447F4C6C
type: Structured Name
full name: Glucose kinase 1

SIP8BA23DC52C011156
type: Structured Name
full name: Hexokinase-1

GK1
type: Gene

SIPF2977F7BE452B356
type: Subunit Annotation
comment: Monomer.

SIP27ECB264C9DBE9D1
type: PTM Annotation
comment: The N-terminus is blocked.

SIPA6B198AFA2EDE2F5
type: Similarity Annotation
comment: Belongs to the bacterial glucokinase family.

PRO_0000215151
type: Chain Annotation
comment: Glucokinase 1
mass: 41585
range: 22862451634026798tt1tt375

22862451634026798tt1
type: Position
type: ExactPosition
position: 1
reference: Q9GTW9-1

22862451634026798tt375
type: Position
type: ExactPosition
position: 375
reference: Q9GTW9-1

22862451634026798tt25
type: Position
type: ExactPosition
position: 25
reference: Q9GTW9-1

22862451634026798tt30
type: Position
type: ExactPosition
position: 30
reference: Q9GTW9-1

Q9GTW9-1
type: Simple Sequence
modified: 2001-03-01
version: 1
mass: 41585
value: MFSIDLIQQIKEWKRGSTLPICLGCDVGGSGLRVRLSDFHDSAKYVDLGHAKAQKTAELLKVLEDLQQKILQVEPTTVCLGAAIAVAGPIKNNTVILTNWKGPAEERTLSITQLPKGLFPKDRSYFLNDLEAGAYGVIAAYEQSILEENFVQLFTDRAPTGPILAKGRTAVLAMGSGLGAALVTRTPLLKNPLVLPTELGHLQIAPNMATHKYFQDEQELIQHISDHYYGGKLDPEYEDICSGRGLQLAFQFYHKKLTGEVLPLEQIDAGDVAKKAIAGEKDAYNALRAHYIFYLRAAKAIATSLSCESCVLSLDNQVKNHPFVMKIAKELEEEFYEFIRPDWMTSVRVYSQKSILNFNILGTDYMAHAIANKPQ

http://purl.uniprot.org/uniprot/Q9GTW9#attribution-DC036A124EC8E88DF072B29F6D9BB9FE
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/Q9GTW9#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

Q9GTW8
type: Protein
reviewed: true
created: 2002-01-23
modified: 2023-05-03
version: 61
mnemonic: GLK2_TRIVA
citation: http://purl.uniprot.org/citations/11250082
recommended name: SIP8D65E42C95A6F7CF
alternative name: SIP85CB0A80A1E1D01D
alternative name: SIP2B5007A7F936CD15
enzyme: http://purl.uniprot.org/enzyme/2.7.1.2
organism: http://purl.uniprot.org/taxonomy/5722
annotation: SIP9AD575AE8BEAADA9
annotation: SIP92C18D71C36C75E6
annotation: PRO_0000215152
annotation: SIPEB9B822A24D39854
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/324
classified with: http://purl.uniprot.org/keywords/418
classified with: GO_0005524
classified with: GO_0004340
classified with: GO_0005536
classified with: GO_0006096
sequence: Q9GTW8-1

Q9GTW8-citation-11250082
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

ATCC 30001 / NIH-C1
type: Strain

SIP8D65E42C95A6F7CF
type: Structured Name
full name: Probable glucokinase 2
ec name: 2.7.1.2

SIP85CB0A80A1E1D01D
type: Structured Name
full name: Glucose kinase 2

SIP2B5007A7F936CD15
type: Structured Name
full name: Hexokinase-2

GK2
type: Gene

SIP92C18D71C36C75E6
type: Similarity Annotation
comment: Belongs to the bacterial glucokinase family.

PRO_0000215152
type: Chain Annotation
comment: Probable glucokinase 2
mass: 41773
range: 22862451634026542tt1tt377

22862451634026542tt1
type: Position
type: ExactPosition
position: 1
reference: Q9GTW8-1

22862451634026542tt377
type: Position
type: ExactPosition
position: 377
reference: Q9GTW8-1

22862451634026542tt27
type: Position
type: ExactPosition
position: 27
reference: Q9GTW8-1

22862451634026542tt32
type: Position
type: ExactPosition
position: 32
reference: Q9GTW8-1

Q9GTW8-1
type: Simple Sequence
modified: 2001-03-01
version: 1
mass: 41773
value: MFDIELVKKINDWKVSEDGALPICIGCDVGGSGLRVRISSFNDSEKYVDLGHAKAKCTKQLVDVLADLEQKIKQVNDKFVCLGAAIAVAGPIKAGTVILTNWQGEPAVRTLTLKDLPQKIFPKDRSVFLNDLEAGAYGVIAAADKDILEQNFVQLFQDKAPKGPVLANGRTAVLAMGSGLGAALVVRTPLLKNPLVLPTELGHVQIAPNMKEHKNFKQERELIQHISNHYYKGELDPEYEDICSGRGLPLAYQFYHQKKTGELLPVEQIDAGEVAKKAMDGEEDAVDALKAHYIFYLRAAKAIATSLSCESCVLSLDNQVKNHPFVMKIMKELEDEFYEFIRPDWMNGLRVYSQKSILNFNILGTDYMAHAIANKPE

http://purl.uniprot.org/uniprot/Q9GTW8#attribution-DC036A124EC8E88DF072B29F6D9BB9FE
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/Q9GTW8#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

O97439
type: Protein
reviewed: true
created: 2000-05-30
modified: 2023-09-13
version: 76
mnemonic: GNPI1_GIAIN
old mnemonic: GNP1_GIALA
old mnemonic: GNPI1_GIALA
citation: SIPFD60E07C1701CF45
recommended name: SIPE6DE32C6E0932390
alternative name: SIPF8768E0F76EABB83
enzyme: http://purl.uniprot.org/enzyme/3.5.99.6
organism: http://purl.uniprot.org/taxonomy/5741
annotation: SIP87FC308C030B4FDD
annotation: SIPCCB1BCC5AFBEADB6
annotation: SIPB7934B14673FDCCC
annotation: PRO_0000160127
annotation: SIP8B76F4F85F2C4E9D
annotation: SIP26CA9CBE6137C198
annotation: SIP7CB5F9DA35CFB400
annotation: SIPC1C25F1EEA8F0A08
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/119
classified with: http://purl.uniprot.org/keywords/378
classified with: GO_0004342
classified with: GO_0005975
classified with: GO_0006044
sequence: O97439-1

SIPFD60E07C1701CF45
type: Submission Citation
title: Cloning of two Giardia glucosamine 6-phosphate isomerase genes only one of which is transcriptionally activated during encystment.
author: van Keulen H.
author: Steimle P.A.
author: Bulik D.A.
author: Borowiak R.K.
author: Jarroll E.L.
date: 1998-02
submitted to: EMBL/GenBank/DDBJ

O97439-citation-SIPFD60E07C1701CF45
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

MR4 / Polish genotype
type: Strain

KOG3148
type: Resource
database: eggNOG
comment: Eukaryota

cd01399
type: Resource
database: CDD
comment: GlcN6P_deaminase
signature sequence match: CDD cd01399 match 1

MF_01241
type: Resource
database: HAMAP
comment: GlcN6P_deamin
signature sequence match: HAMAP MF 01241 match 1

IPR006148
type: Resource
database: InterPro
comment: Glc/Gal-6P_isomerase

IPR004547
type: Resource
database: InterPro
comment: Glucosamine6P_isomerase

IPR018321
type: Resource
database: InterPro
comment: Glucosamine6P_isomerase_CS

IPR037171
type: Resource
database: InterPro
comment: NagB/RpiA_transferase-like

TIGR00502
type: Resource
database: NCBIfam
comment: nagB
signature sequence match: NCBIfam TIGR00502 match 1

PTHR11280
type: Resource
database: PANTHER
comment: GLUCOSAMINE-6-PHOSPHATE ISOMERASE
signature sequence match: PANTHER PTHR11280 match 1

PTHR11280:SF5
type: Resource
database: PANTHER
comment: GLUCOSAMINE-6-PHOSPHATE ISOMERASE
signature sequence match: PANTHER PTHR11280:SF5 match 1

PF01182
type: Resource
database: Pfam
comment: Glucosamine_iso
signature sequence match: Pfam PF01182 match 1

SSF100950
type: Resource
database: SUPFAM
comment: NagB/RpiA/CoA transferase-like
signature sequence match: SUPFAM SSF100950 match 1

PS01161
type: Resource
database: PROSITE
comment: GLC_GALNAC_ISOMERASE
signature sequence match: PROSITE PS01161 match 1

SIPE6DE32C6E0932390
type: Structured Name
full name: Glucosamine-6-phosphate isomerase 1
ec name: 3.5.99.6

SIPF8768E0F76EABB83
type: Structured Name
full name: Glucosamine-6-phosphate deaminase 1
short name: GNPDA 1
short name: GlcN6P deaminase 1

GPI1
type: Gene

SIPCCB1BCC5AFBEADB6
type: Subunit Annotation
comment: Homohexamer.

SIPB7934B14673FDCCC
type: Similarity Annotation
comment: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.

PRO_0000160127
type: Chain Annotation
comment: Glucosamine-6-phosphate isomerase 1
mass: 29406
range: 22299432421898542tt1tt266

22299432421898542tt1
type: Position
type: ExactPosition
position: 1
reference: O97439-1

22299432421898542tt266
type: Position
type: ExactPosition
position: 266
reference: O97439-1

SIP8B76F4F85F2C4E9D
type: Active Site Annotation
comment: Proton acceptor; for enolization step
range: 22299432421898542tt67tt67

22299432421898542tt67
type: Position
type: ExactPosition
position: 67
reference: O97439-1

SIP26CA9CBE6137C198
type: Active Site Annotation
comment: For ring-opening step
range: 22299432421898542tt136tt136

22299432421898542tt136
type: Position
type: ExactPosition
position: 136
reference: O97439-1

SIP7CB5F9DA35CFB400
type: Active Site Annotation
comment: Proton acceptor; for ring-opening step
range: 22299432421898542tt138tt138

22299432421898542tt138
type: Position
type: ExactPosition
position: 138
reference: O97439-1

SIPC1C25F1EEA8F0A08
type: Active Site Annotation
comment: For ring-opening step
range: 22299432421898542tt143tt143

22299432421898542tt143
type: Position
type: ExactPosition
position: 143
reference: O97439-1

O97439-1
type: Simple Sequence
modified: 1999-05-01
version: 1
mass: 29406
value: MPSIHVSKCADPAIKLAHRIAEVVRSKPNCVLGLATGSTPIPVYQELARLHREEGLDFSQVRTFNLDEYAGLPPTHDQTYRFFMEEHLFSKVNIKPENVHFLNGMASDYEKECERYEQELKAIGPCDVWLLGIGHNGHIAFNEPGSPRDSRTRVVCLTQSTIDANARFFGNDKSKVPTKALSVGIATIMESREILLLATGESKREAVTKSVKGKCETHCPASFLHEHPHCRFYVDMDAGKVVDNTCCQATNQASCCGSTSCHAAKA

http://purl.uniprot.org/uniprot/O97439#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/O97439#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

O97440
type: Protein
reviewed: true
created: 2000-05-30
modified: 2023-09-13
version: 76
mnemonic: GNPI2_GIAIN
old mnemonic: GNP2_GIALA
old mnemonic: GNPI2_GIALA
citation: SIPFD60E07C1701CF45
recommended name: SIP396225394E2B91EA
alternative name: SIPA2CA7CB4460AA7C0
enzyme: http://purl.uniprot.org/enzyme/3.5.99.6
organism: http://purl.uniprot.org/taxonomy/5741
annotation: SIPAF5BC4EDC1335817
annotation: SIP0CD1B5CDD2F8D631
annotation: SIPBE6E816850A9E921
annotation: PRO_0000160128
annotation: SIP514DB67DFC89D9BA
annotation: SIPEF829B1F547C2D65
annotation: SIP82449FFE246260DF
annotation: SIP997097E8624D24F6
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/119
classified with: http://purl.uniprot.org/keywords/378
classified with: GO_0004342
classified with: GO_0005975
classified with: GO_0006044
sequence: O97440-1

O97440-citation-SIPFD60E07C1701CF45
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

MR4 / Polish genotype
type: Strain

SIP396225394E2B91EA
type: Structured Name
full name: Glucosamine-6-phosphate isomerase 2
ec name: 3.5.99.6

SIPA2CA7CB4460AA7C0
type: Structured Name
full name: Glucosamine-6-phosphate deaminase 2
short name: GNPDA 2
short name: GlcN6P deaminase 2

GPI2
type: Gene

SIP0CD1B5CDD2F8D631
type: Subunit Annotation
comment: Homohexamer.

SIPBE6E816850A9E921
type: Similarity Annotation
comment: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.

PRO_0000160128
type: Chain Annotation
comment: Glucosamine-6-phosphate isomerase 2
mass: 28768
range: 22299432421961774tt1tt263

22299432421961774tt1
type: Position
type: ExactPosition
position: 1
reference: O97440-1

22299432421961774tt263
type: Position
type: ExactPosition
position: 263
reference: O97440-1

SIP514DB67DFC89D9BA
type: Active Site Annotation
comment: Proton acceptor; for enolization step
range: 22299432421961774tt82tt82

22299432421961774tt82
type: Position
type: ExactPosition
position: 82
reference: O97440-1

SIPEF829B1F547C2D65
type: Active Site Annotation
comment: For ring-opening step
range: 22299432421961774tt151tt151

22299432421961774tt151
type: Position
type: ExactPosition
position: 151
reference: O97440-1

SIP82449FFE246260DF
type: Active Site Annotation
comment: Proton acceptor; for ring-opening step
range: 22299432421961774tt153tt153

22299432421961774tt153
type: Position
type: ExactPosition
position: 153
reference: O97440-1

SIP997097E8624D24F6
type: Active Site Annotation
comment: For ring-opening step
range: 22299432421961774tt158tt158

22299432421961774tt158
type: Position
type: ExactPosition
position: 158
reference: O97440-1

O97440-1
type: Simple Sequence
modified: 1999-05-01
version: 1
mass: 28768
value: MTVCVAQAERGASELESKAMVKKSNDAALLVAHRIAEVVRSKPNCVLGLATGSTPIPVYQELARLHREEGLDFSQVRTFNLDEYAGLPPTHDQSYRFFMEEHLFSKVNIKPENVHFLSGLAIRAEDECIRYENALQTIGPCDVWLLGIGHNGHIAFNEPGSPRDSRTRVVCLTQSTIDANARFFGNDKSKVPTKALSVGIATIMESREILLLATGESKCEAVTKAIVGEPTNAVPASLLQRHPRCCFYVDEAAGAEVAETVTE

http://purl.uniprot.org/uniprot/O97440#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/O97440#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

Q86D96
type: Protein
reviewed: true
created: 2003-10-10
modified: 2023-05-03
version: 91
mnemonic: GPA1_TRIVA
old mnemonic: GBA1_TRIVA
citation: http://purl.uniprot.org/citations/12850262
recommended name: SIPEE8914BED773E1CB
alternative name: SIP770DA51217FB91BD
organism: http://purl.uniprot.org/taxonomy/5722
annotation: SIPC64B94BAD62CE56E
annotation: SIPA64A393DC31FF713
annotation: SIP7762E19F648597EF
annotation: SIP40F9F30510273E2E
annotation: SIPCFF9E54686DAE3CF
annotation: PRO_0000203668
annotation: SIPCEAF3662A4271278
annotation: SIP266CB7125AF1A5E2
annotation: SIP8851BD7367331C7A
annotation: SIPF377A64B9B237105
annotation: SIPC4F37182178EE040
annotation: SIP73576120ED9C9B5D
annotation: SIP504E0C1ABB3EAC08
annotation: SIP54A7383591022586
annotation: SIP0C438C39CC7E13D3
annotation: SIPD18DF8046710FDEB
annotation: SIPC7D3F6BEBF30AB98
annotation: SIPE72707A9B2770D88
annotation: SIP42D52F3DAC7098B0
annotation: SIPD9494CFD897CE8A2
annotation: SIPEA031E67808B4285
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/342
classified with: http://purl.uniprot.org/keywords/472
classified with: http://purl.uniprot.org/keywords/519
classified with: http://purl.uniprot.org/keywords/564
classified with: http://purl.uniprot.org/keywords/807
classified with: GO_0012505
classified with: GO_0016020
classified with: GO_0048471
classified with: GO_0031683
classified with: GO_0005525
classified with: GO_0003924
classified with: GO_0007186
sequence: Q86D96-1

Q86D96-citation-12850262
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

ATCC PRA-98 / G3
type: Strain

KOG0082
type: Resource
database: eggNOG
comment: Eukaryota

cd00066
type: Resource
database: CDD
comment: G-alpha
signature sequence match: CDD cd00066 match 1

http://purl.uniprot.org/gene3d/1.10.400.10
type: Resource
database: Gene3D
comment: GI Alpha 1, domain 2-like
signature sequence match: Gene3D 1.10.400.10 match 1

IPR001019
type: Resource
database: InterPro
comment: Gprotein_alpha_su

IPR011025
type: Resource
database: InterPro
comment: GproteinA_insert

PTHR10218
type: Resource
database: PANTHER
comment: GTP-BINDING PROTEIN ALPHA SUBUNIT
signature sequence match: PANTHER PTHR10218 match 1

PTHR10218:SF302
type: Resource
database: PANTHER
comment: GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG
signature sequence match: PANTHER PTHR10218:SF302 match 1

PF00503
type: Resource
database: Pfam
comment: G-alpha
signature sequence match: Pfam PF00503 match 1

PR00318
type: Resource
database: PRINTS
comment: GPROTEINA

SM00275
type: Resource
database: SMART
comment: G_alpha
signature sequence match: SMART SM00275 match 1

SSF47895
type: Resource
database: SUPFAM
comment: Transducin (alpha subunit), insertion domain
signature sequence match: SUPFAM SSF47895 match 1

PS51882
type: Resource
database: PROSITE
comment: G_ALPHA
signature sequence match: PROSITE PS51882 match 1

SIPEE8914BED773E1CB
type: Structured Name
full name: Guanine nucleotide-binding protein subunit alpha-1
short name: G alpha-1

SIP770DA51217FB91BD
type: Structured Name
full name: GTP-binding protein subunit alpha 1

GA1
type: Gene

SIPC64B94BAD62CE56E
type: Function Annotation
comment: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

SIPA64A393DC31FF713
type: Subunit Annotation
comment: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

SIP7762E19F648597EF
type: Subcellular Location Annotation
comment: Predominantly perinuclear.
located in: SIPB9D96F17A1A3A0D3
located in: SIPFB4189AD0CF45E55
located in: SIP1D9EB1163CC9A651

SIP40F9F30510273E2E
type: Similarity Annotation
comment: Belongs to the G-alpha family.

SIPCFF9E54686DAE3CF
type: Initiator Methionine Annotation
comment: Removed
range: 22861278837552686tt1tt1

22861278837552686tt1
type: Position
type: ExactPosition
position: 1
reference: Q86D96-1

PRO_0000203668
type: Chain Annotation
comment: Guanine nucleotide-binding protein subunit alpha-1
mass: 45100
range: 22861278837552686tt2tt402

22861278837552686tt2
type: Position
type: ExactPosition
position: 2
reference: Q86D96-1

22861278837552686tt402
type: Position
type: ExactPosition
position: 402
reference: Q86D96-1

SIPCEAF3662A4271278
type: Domain Extent Annotation
comment: G-alpha
range: 22861278837552686tt82tt402

22861278837552686tt82
type: Position
type: ExactPosition
position: 82
reference: Q86D96-1

SIP266CB7125AF1A5E2
type: Region Annotation
comment: Disordered
range: 22861278837552686tt1tt70

22861278837552686tt70
type: Position
type: ExactPosition
position: 70
reference: Q86D96-1

SIP8851BD7367331C7A
type: Region Annotation
comment: G1 motif
range: 22861278837552686tt85tt98

22861278837552686tt85
type: Position
type: ExactPosition
position: 85
reference: Q86D96-1

22861278837552686tt98
type: Position
type: ExactPosition
position: 98
reference: Q86D96-1

SIPF377A64B9B237105
type: Region Annotation
comment: G2 motif
range: 22861278837552686tt221tt229

22861278837552686tt221
type: Position
type: ExactPosition
position: 221
reference: Q86D96-1

22861278837552686tt229
type: Position
type: ExactPosition
position: 229
reference: Q86D96-1

SIPC4F37182178EE040
type: Region Annotation
comment: G3 motif
range: 22861278837552686tt244tt253

22861278837552686tt244
type: Position
type: ExactPosition
position: 244
reference: Q86D96-1

22861278837552686tt253
type: Position
type: ExactPosition
position: 253
reference: Q86D96-1

SIP73576120ED9C9B5D
type: Region Annotation
comment: G4 motif
range: 22861278837552686tt313tt320

22861278837552686tt313
type: Position
type: ExactPosition
position: 313
reference: Q86D96-1

22861278837552686tt320
type: Position
type: ExactPosition
position: 320
reference: Q86D96-1

SIP504E0C1ABB3EAC08
type: Region Annotation
comment: G5 motif
range: 22861278837552686tt375tt380

22861278837552686tt375
type: Position
type: ExactPosition
position: 375
reference: Q86D96-1

22861278837552686tt380
type: Position
type: ExactPosition
position: 380
reference: Q86D96-1

SIP54A7383591022586
type: Compositional Bias Annotation
comment: Pro residues
range: 22861278837552686tt31tt68

22861278837552686tt31
type: Position
type: ExactPosition
position: 31
reference: Q86D96-1

22861278837552686tt68
type: Position
type: ExactPosition
position: 68
reference: Q86D96-1

22861278837552686tt90
type: Position
type: ExactPosition
position: 90
reference: Q86D96-1

22861278837552686tt97
type: Position
type: ExactPosition
position: 97
reference: Q86D96-1

22861278837552686tt223
type: Position
type: ExactPosition
position: 223
reference: Q86D96-1

22861278837552686tt248
type: Position
type: ExactPosition
position: 248
reference: Q86D96-1

22861278837552686tt252
type: Position
type: ExactPosition
position: 252
reference: Q86D96-1

22861278837552686tt317
type: Position
type: ExactPosition
position: 317
reference: Q86D96-1

22861278837552686tt377
type: Position
type: ExactPosition
position: 377
reference: Q86D96-1

SIPD9494CFD897CE8A2
type: Lipidation Annotation
comment: N-myristoyl glycine
range: 22861278837552686tt2tt2

SIPEA031E67808B4285
type: Lipidation Annotation
comment: S-palmitoyl cysteine
range: 22861278837552686tt3tt3

22861278837552686tt3
type: Position
type: ExactPosition
position: 3
reference: Q86D96-1

Q86D96-1
type: Simple Sequence
modified: 2003-06-01
version: 1
mass: 45231
value: MGCSASKPSEPSNAKLPSAPVPKKVEQVPEPKPEPQPQPEPQPQPEPPKPAEPAPAPAPAPEPQKPAEPAPKVVAVEDDTNEAYGLLLCGAGESGKTTFTRQLKLRYLNGFNEKDCRDFLRTIRGNLVETMQLLLVWLEHNNIEIEDSELSSMAQDIIDVDPQDCEFNEELVEKLKALWENEQIKKAFEHKDETAVPDHMPYFFAKIDELAGEDYIPSNEDVLRARIRSIGIEAITFDLQGARIRIFDVGGQKSERSKWANVMNQVEGVIFCVSFAEFDKPMFEDQNVLRINDSLEIFGNITHQEKFSNSPIFLVCNKFDVFTEKIKNTDAFVKIFPEFSGDSHNPEACADYLIQRFLDKAAPLSEDRPIIQYKIVALNGDQVVETADAICKFISDKYYQDA

http://purl.uniprot.org/uniprot/Q86D96#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
manual: true
evidence: ECO_0000250

http://purl.uniprot.org/uniprot/Q86D96#attribution-DC036A124EC8E88DF072B29F6D9BB9FE
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/Q86D96#attribution-1B5F18AB70D26AFF2F8B2CF05DC5F702
manual: true
evidence: ECO_0000255
source: PRU01230

http://purl.uniprot.org/uniprot/Q86D96#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

P51900
type: Protein
reviewed: true
created: 1996-10-01
modified: 2023-09-13
version: 100
mnemonic: HGXR_TRIFO
old mnemonic: HGXR_TRIFP
citation: http://purl.uniprot.org/citations/8008020
citation: http://purl.uniprot.org/citations/8679528
citation: http://purl.uniprot.org/citations/8774725
recommended name: SIP90B8AE45B6CA517E
enzyme: http://purl.uniprot.org/enzyme/2.4.2.22
enzyme: http://purl.uniprot.org/enzyme/2.4.2.8
organism: http://purl.uniprot.org/taxonomy/56690
annotation: SIPCFAA0AF3A33C0A5B
annotation: SIPD4F4DAF7ED3F0D47
annotation: SIP33FDB0DB2DFFFFD1
annotation: SIP4683EF33531F4CF2
annotation: SIP158823400F60205C
annotation: SIP92038B7C11D9D050
annotation: SIPDE5B44972D6569D6
annotation: SIP4502E4AE4E3F7C9E
annotation: SIPEC8B985D42C42C54
annotation: SIP88381014919D5636
annotation: SIPCEFA2F06B5947BA8
annotation: SIP2B955869E07F970D
annotation: PRO_0000139600
annotation: SIP16BB28CEF7BE7B25
annotation: SIP142FC714117E6166
annotation: SIP960D7BAEEA6BB551
annotation: SIP2E88DBA5E1BAFB07
annotation: SIP31C38B15D02786A6
annotation: SIPD0AEEEEB2B5D35D0
annotation: SIPEF124F28F992F82F
annotation: SIP5C2AB02C521F77D8
annotation: SIPA2CB873FBBCEBCCB
annotation: SIP6981C84C6E3D5ECA
annotation: SIP0BFE753D7B3E912C
annotation: SIP66CAB618F26F4A2A
annotation: SIP60D095B8FD061967
annotation: SIPFA85FFC3AB95FBE6
annotation: SIP2AFD2D475CF3EB5E
annotation: SIPB9B568EAA257B55A
annotation: SIPEDCA3253DAFEEE7A
annotation: SIP505651877DFA1321
annotation: SIP19DFC04D7F95F439
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/328
classified with: http://purl.uniprot.org/keywords/460
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/547
classified with: http://purl.uniprot.org/keywords/660
classified with: GO_0005737
classified with: GO_0052657
classified with: GO_0004422
classified with: GO_0046872
classified with: GO_0000166
classified with: GO_0000310
classified with: GO_0032263
classified with: GO_0032264
classified with: GO_0006166
classified with: GO_0032265
sequence: P51900-1

P51900-citation-8008020
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE

KV1
type: Strain

P51900-citation-8679528
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS)
scope: MASS SPECTROMETRY

P51900-citation-8774725
type: Citation Statement
scope: COVALENT MODIFICATION OF CYSTEINES

1HGX
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 1.90
chain sequence mapping: PDB 1HGX tt1tt183

PDB 1HGX tt1tt183
chain: A/B=1-183

cd06223
type: Resource
database: CDD
comment: PRTases_typeI
signature sequence match: CDD cd06223 match 1

IPR005904
type: Resource
database: InterPro
comment: Hxn_phspho_trans

IPR000836
type: Resource
database: InterPro
comment: PRibTrfase_dom

IPR029057
type: Resource
database: InterPro
comment: PRTase-like

TIGR01203
type: Resource
database: NCBIfam
comment: HGPRTase
signature sequence match: NCBIfam TIGR01203 match 1

PTHR43340:SF1
type: Resource
database: PANTHER
comment: HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE
signature sequence match: PANTHER PTHR43340:SF1 match 1

PTHR43340
type: Resource
database: PANTHER
comment: HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE
signature sequence match: PANTHER PTHR43340 match 1

PF00156
type: Resource
database: Pfam
comment: Pribosyltran
signature sequence match: Pfam PF00156 match 1

SSF53271
type: Resource
database: SUPFAM
comment: PRTase-like
signature sequence match: SUPFAM SSF53271 match 1

PS00103
type: Resource
database: PROSITE
comment: PUR_PYR_PR_TRANSFER
signature sequence match: PROSITE PS00103 match 1