Extensive metabolic versatility and redundancy in microbially diverse, dynamic hydrothermal sediments.
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED
Glucocorticoid receptor-like (DNA-binding domain)
Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.
Belongs to the eukaryotic ribosomal protein eL24 family.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
Belongs to the eukaryotic ribosomal protein eS8 family.
TRANSCRIPTION TERMINATION/ANTITERMINATION PROTEIN NUSA
Prokaryotic type KH domain (KH-domain type II)
Probable transcription termination protein NusA
Participates in transcription termination.
Ribosomal-protein-alanine N-acetyltransferase
Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
Heterohexamer of two alpha and four beta subunits.
Belongs to the prefoldin subunit beta family.
5' to 3' exonuclease, C-terminal subdomain
DNA-directed RNA polymerase subunit Rpo11
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
DNA-directed RNA polymerase RBP11-like dimerisation
Belongs to the eukaryotic ribosomal protein eL39 family.
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
Belongs to the universal ribosomal protein uL22 family.
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Consists of a catalytic RNA component and at least 4-5 protein subunits.
Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.
Belongs to the universal ribosomal protein uL14 family.
P-loop containing nucleotide triphosphate hydrolases
P-loop containing nucleoside triphosphate hydrolases
Cob(I)yrinic acid a,c-diamide adenosyltransferase
Belongs to the universal ribosomal protein uS15 family.
Metalloproteases ('zincins'), catalytic domain
Probable zinc metalloprotease whose natural substrate is unknown.
Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.
FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD
Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
Lacks conserved residue(s) required for the propagation of feature annotation.
Belongs to the eukaryotic ribosomal protein eS28 family.
CBS DOMAIN-CONTAINING PROTEIN CBSX3, MITOCHONDRIAL
Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
Belongs to the histone-like Alba family.
Belongs to the eukaryotic ribosomal protein eS27 family.
Located at the polypeptide exit tunnel on the outside of the subunit.
One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
Belongs to the universal ribosomal protein uL24 family.
L-ASPARTATE SEMIALDEHYDE SULFURTRANSFERASE IRON-SULFUR SUBUNIT
DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10
Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
Type II toxin-antitoxin system HicA family toxin
proteasome assembly chaperone family protein
AbrB/MazE/SpoVT family DNA-binding domain-containing protein
4Fe-4S ferredoxin-type domain-containing protein
Asp-tRNA(Asn) amidotransferase GatCAB subunit C
DIPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN DPPB-RELATED
Belongs to the binding-protein-dependent transport system permease family.
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
Belongs to the universal ribosomal protein uS17 family.
HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE
Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
Alpha-D-phosphohexomutase, C-terminal domain
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Belongs to the eukaryotic ribosomal protein eL37 family.
DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1
beta and beta-prime subunits of DNA dependent RNA-polymerase
DNA-directed RNA polymerase subunit Rpo1C
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
Belongs to the RNA polymerase beta' chain family.
30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.
Belongs to the universal ribosomal protein uS13 family.
U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7
Belongs to the snRNP Sm proteins family.
Phosphoribosylformylglycinamidine synthase subunit PurS
Formylglycinamide ribonucleotide amidotransferase subunit III
Phosphoribosylformylglycinamidine synthase subunit III
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
Belongs to the eukaryotic ribosomal protein eS17 family.
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
May be involved in maturation of the 30S ribosomal subunit.
Belongs to the eukaryotic ribosomal protein eS19 family.
NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L
NADH-quinone oxidoreductase subunit NuoK
uncharacterized conserved protein from methanopyrus kandleri domain like
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
Belongs to the universal ribosomal protein uS19 family.
ABC TRANSPORTER ATP-BINDING PROTEIN ALBC-RELATED
ABC transporter domain-containing protein
Belongs to the archaeal histone HMF family.
Transcription factor CBF/NF-Y/archaeal histone
Protein transport protein Sec61 subunit beta homolog
Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.
Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
Belongs to the archaeal DnaG primase family.
Sulphur transport domain-containing protein
DNA-DIRECTED RNA POLYMERASES I, II, AND III
DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC4
DNA-directed RNA polymerase subunit Rpo12
Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
C-terminal domain of transcriptional repressors
Lrp/AsnC family transcriptional regulator
Transcription regulator AsnC/Lrp ligand binding
lambda repressor-like DNA-binding domains
IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED
Fe-S cluster assembly (FSCA) domain-like
NIF system FeS cluster assembly NifU C-terminal
TRANSCRIPTION REGULATOR, LRP/ASNC FAMILY
Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
Homodimer. Heterotetramer of two Top6A and two Top6B chains.
Spo11/DNA topoisomerase VI subunit A N-terminal
Nucleoside Triphosphate Pyrophosphohydrolase
H/ACA ribonucleoprotein complex, subunit Nop10
H/ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3
Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.
BIFUNCTIONAL NMN ADENYLYLTRANSFERASE/NUDIX HYDROLASE
Nicotinamide-nucleotide adenylyltransferase
Belongs to the archaeal NMN adenylyltransferase family.
OLIGOPEPTIDE TRANSPORT ATP-BINDING PROTEIN APPD
ATP PHOSPHORIBOSYLTRANSFERASE ATP-PRTASE
Belongs to the isopentenyl phosphate kinase family.
Medium-chain alcohol dehydrogenases, catalytic domain
VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11
6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase
DIAMINOPIMELATE EPIMERASE, CHLOROPLASTIC
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
Belongs to the diaminopimelate epimerase family.
Could be important to modulate the pK values of the two catalytic cysteine residues
VALINE--TRNA LIGASE, CHLOROPLASTIC/MITOCHONDRIAL 2
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Phenylalanyl-trna Synthetase, Chain B, domain 3
PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE/PHOSPHATASE
Sulfolobus fructose-1,6-bisphosphatase-like
Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
Belongs to the FBP aldolase/phosphatase family.
Proton acceptor; for FBP phosphatase activity
Proton donor/acceptor; for FBP aldolase activity
Schiff-base intermediate with DHAP; for FBP aldolase activity
VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 29
Belongs to the metallophosphoesterase superfamily. YfcE family.
ABC-2 type transporter transmembrane domain-containing protein
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.
Belongs to the 2H phosphoesterase superfamily. ThpR family.
Histidine kinase-like ATPase, C-terminal domain
PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Homodimeric domain of signal transducing histidine kinase
N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain
N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE
TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE
S-adenosyl-L-methionine-dependent methyltransferases
tRNA 2,2-dimethylguanosine-26 methyltransferase
tRNA(guanine-26,N(2)-N(2)) methyltransferase
Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
DNA ligase, ATP-dependent, N-terminal domain
ATP-dependent DNA ligase DNA-binding domain
DNA ligase/mRNA capping enzyme, catalytic domain
Belongs to the ATP-dependent DNA ligase family.
N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL
Serine-tRNA synthetase, tRNA binding domain
SERINE--TRNA LIGASE, CYTOPLASMIC-RELATED
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
Homodimer. The tRNA molecule binds across the dimer.
Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
Aminoacyl-transfer RNA synthetases class-II family profile
UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE
6-phosphogluconate dehydrogenase C-terminal domain-like
UDP-glucose/GDP-mannose dehydrogenase C-terminal domain
Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Belongs to the chorismate synthase family.
CRISPR-Cas system, Cmr2 subunit, D1 domain, cysteine cluster
CRISPR SYSTEM SINGLE-STRAND-SPECIFIC DEOXYRIBONUCLEASE CAS10/CSM1 (SUBTYPE III-A)
Type III-B CRISPR-associated protein Cas10/Cmr2
Belongs to the universal ribosomal protein uL16 family.
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.
Belongs to the L-aspartate dehydrogenase family.
Aspartate/homoserine dehydrogenase NAD-binding
Roadblock/LAMTOR2 domain-containing protein
Produces ATP from ADP in the presence of a proton gradient across the membrane.
Belongs to the V-ATPase D subunit family.
HicB-like antitoxin of toxin-antitoxin system domain-containing protein
Adenine nucleotide alpha hydrolases-like
GMP synthetase C-terminal dimerisation domain
GMP synthase [glutamine-hydrolyzing] subunit B
Catalyzes the synthesis of GMP from XMP.
Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).
ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.
Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE
S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED
tRNA wyosine derivatives biosynthesis protein Taw1
Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
ATPASE INVOLVED IN CHROMOSOME PARTITIONING, PARA/MIND FAMILY
SEPTUM SITE-DETERMINING PROTEIN MIND HOMOLOG, CHLOROPLASTIC-RELATED
Belongs to the ParA family. MinD subfamily.
Ribosomal protein L11, C-terminal domain
Ribosomal protein L11/L12, N-terminal domain
39S RIBOSOMAL PROTEIN L11, MITOCHONDRIAL
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.
Belongs to the universal ribosomal protein uL11 family.
CLASS IV SAM-BINDING METHYLTRANSFERASE-RELATED
archaeosine biosynthesis radical SAM protein RaSEA
Guanylate cyclase domain-containing protein
Purple acid phosphatase-like, N-terminal
Purple acid phosphatase, N-terminal domain
Ribonuclease H-like superfamily/Ribonuclease H
Iron-sulfur cluster assembly scaffold protein
Forms part of the polypeptide exit tunnel.
One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
Belongs to the universal ribosomal protein uL4 family.
COB--COM HETERODISULFIDE REDUCTASE IRON-SULFUR SUBUNIT A
FERREDOXIN:COB-COM HETERODISULFIDE REDUCTASE SUBUNIT A
Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.
Aminoglycoside phosphotransferase domain-containing protein
Spermidine synthase, tetramerisation domain
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
Belongs to the spermidine/spermine synthase family.
3-phosphoshikimate 1-carboxyvinyltransferase
5-enolpyruvylshikimate-3-phosphate synthase
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
3-OCTAPRENYL-4-HYDROXYBENZOATE CARBOXY-LYASE-RELATED
Belongs to the class-I aminoacyl-tRNA synthetase family.
Methionyl-tRNA synthetase anticodon-binding
Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
Belongs to the thymidylate kinase family.
Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
3-isopropylmalate dehydratase large subunit
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Belongs to the eukaryotic ribosomal protein eS1 family.
ARCHAEAL FLAGELLA-RELATED PROTEIN F-RELATED
Sporulation stage II protein D amidase enhancer LytB N-terminal domain-containing protein
Sporulation stage II protein D amidase enhancer LytB N-terminal
HTH-TYPE TRANSCRIPTIONAL REGULATOR TRMBL2
Transcription regulator TrmB C-terminal domain-containing protein
EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN
Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.
Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
Belongs to the RNase PH family. Rrp42 subfamily.
Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))
2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain
Belongs to the alpha-IPM synthase/homocitrate synthase family.
HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE C
Histidine kinase domain-containing protein
Prepilin type IV endopeptidase peptidase domain-containing protein
Prepilin type IV endopeptidase peptidase
Diphthamide synthesis DPH1/DPH2 domain 1
ArnR1-like winged helix-turn-helix domain-containing protein
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
TRANSCRIPTION REGULATOR, ENCODED NEXT TO RECA SUPERFAMILY ATPASE-RELATED
KaiC associated regulatory domain-containing protein
SLC41 divalent cation transporters, integral membrane domain
Belongs to the SLC41A transporter family.
HYDROGENASE ISOENZYMES FORMATION PROTEIN HYPE
Hydrogenase expression/formation protein HypE
Pseudouridine synthase I, catalytic domain, C-terminal subdomain
Pseudouridine synthase I, catalytic domain, N-terminal subdomain
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
Belongs to the tRNA pseudouridine synthase TruA family.
Pseudouridine synthase I TruA alpha/beta
PYRUVATE-FLAVODOXIN OXIDOREDUCTASE-RELATED
Thiamin diphosphate-binding fold (THDP-binding)
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
EUKARYOTIC TRANSLATION INITIATION FACTOR 6
Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.
PAS domain-containing sensor histidine kinase
Cas12f1-like TNB domain-containing protein
SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL
Mechanosensitive channel protein MscS (YggB), C-terminal domain
Mechanosensitive channel protein MscS (YggB), transmembrane region
Mechanosensitive ion channel family protein
ABC TRANSPORTER ATP-BINDING PROTEIN NATA
Heme ABC exporter ATP-binding protein CcmA
SirC, precorrin-2 dehydrogenase, C-terminal helical domain-like
With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.
Belongs to the universal ribosomal protein uS12 family.
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.
Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
S-layer protein C-terminal domain-containing protein
Single-stranded right-handed beta-helix, Pectin lyase-like
Carbohydrate-binding/sugar hydrolysis domain-containing protein
NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL
Formate dehydrogenase/DMSO reductase, domains 1-3
Formylmethanofuran dehydrogenase subunit B
Carboxypeptidase-like, regulatory domain
Carboxypeptidase regulatory-like domain-containing protein
DNA methylase adenine-specific domain-containing protein
UDP-Glycosyltransferase/glycogen phosphorylase
Glycosyltransferase subfamily 4-like N-terminal
GLYCEROL-3-PHOSPHATE CYTIDYLYLTRANSFERASE
Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
Belongs to the archaeal FAD synthase family.
RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE K/L
Class I SAM-dependent RNA methyltransferase
Zinc finger ZPR1-type domain-containing protein
RdgB/HAM1 family non-canonical purine NTP pyrophosphatase
INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN
Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family
Ribosome maturation protein SBDS, N-terminal domain
SBDS protein C-terminal domain, subdomain 1
RESTRICTION OF TELOMERE CAPPING PROTEIN 3
Hypothetical protein AF0491, middle domain
Ribosome maturation protein SDO1/SBDS N-terminal
Ribosome maturation protein SDO1/SBDS central
Ribosome maturation protein SDO1/SBDS C-terminal
40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11
Located on the platform of the 30S subunit.
Belongs to the universal ribosomal protein uS11 family.
TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE-RELATED
Glutamyl-tRNA(Gln) amidotransferase subunit D
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
Belongs to the asparaginase 1 family. GatD subfamily.
Type II secretion system protein GspF domain-containing protein
3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE
Nitrogenase molybdenum iron protein domain
HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
Belongs to the histidinol dehydrogenase family.
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
Belongs to the universal ribosomal protein uL5 family.
ibrinogen binding protein from staphylococcus aureus domain
Fibronectin-binding domain-containing protein
Belongs to the carbamoyltransferase HypF family.
Type II secretion system, protein E, N-terminal domain
TYPE II SECRETION SYSTEM PROTEIN GSPE-RELATED
Bacterial type II secretion system protein E
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.
Belongs to the universal ribosomal protein uL2 family.
Creatinase/methionine aminopeptidase superfamily
Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.
Type I-A CRISPR-associated protein Cas4/Csa1
Right handed beta helix domain-containing protein
Membrane protein 6-pyruvoyl-tetrahydropterin synthase-related domain-containing protein
HYPOTHETICAL MEMBRANE PROTEIN, CONSERVED, DUF373 FAMILY
Probable S-methyl-5'-thioinosine phosphorylase
Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE
PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE
L-isoaspartyl protein carboxyl methyltransferase
Protein-beta-aspartate methyltransferase
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
Class III signal peptide-containing protein
PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE-RELATED
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)
Nickel pincer cofactor biosynthesis protein LarB
S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME
S-adenosylmethionine decarboxylase beta chain
S-adenosylmethionine decarboxylase alpha chain
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
Binds 1 pyruvoyl group covalently per subunit.
Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.
Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
Schiff-base intermediate with substrate; via pyruvic acid
Proton acceptor; for processing activity
TIGR04053 family radical SAM/SPASM domain-containing protein
TUNGSTEN-CONTAINING ALDEHYDE FERREDOXIN OXIDOREDUCTASE COFACTOR MODIFYING PROTEIN
Radical SAM/SPASM domain-containing protein
3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT 1-RELATED
3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT 2-RELATED-RELATED
3-isopropylmalate dehydratase small subunit
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Belongs to the LeuD family. LeuD type 2 subfamily.
Aconitase A/isopropylmalate dehydratase small subunit swivel
K(+)-INSENSITIVE PYROPHOSPHATE-ENERGIZED PROTON PUMP
Membrane-bound proton-translocating pyrophosphatase
Pyrophosphate-energized inorganic pyrophosphatase
Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.
Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)
Formate/glycerate dehydrogenase catalytic domain-like
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
DNA polymerase family B, C-terminal domain
Belongs to the DNA polymerase type-B family.
DNA-directed DNA polymerase family B multifunctional
Belongs to the prefoldin alpha subunit family.
Belongs to the prefoldin subunit alpha family.
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
YggS family pyridoxal phosphate-dependent enzyme
PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN
Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.
Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.
Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
Belongs to the type II topoisomerase GyrB family.
3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE
In the N-terminal section; belongs to the DHBP synthase family.
2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE
COFACTOR-INDEPENDENT PHOSPHOGLYCERATE MUTASE
phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
Archaeal Type IV pilin N-terminal domain-containing protein
Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
Translation initiation factor IF- 2, domain 3
EUKARYOTIC TRANSLATION INITIATION FACTOR 5B
TRANSLATION INITIATION FACTOR IF-2-RELATED
Probable translation initiation factor IF-2
Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
Winged helix-turn-helix transcriptional regulator
CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE
METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED
Glutathione synthetase ATP-binding domain-like
Acetyl-CoA carboxylase biotin carboxylase subunit
Heterotetramer of one alpha, one beta, one delta and one gamma chain.
Methanolan biosynthesis EpsI domain-containing protein
Structural maintenance of chromosome 1. Chain E
Formylmethanofuran:tetrahydromethanopterin formyltransferase
Formylmethanofuran--tetrahydromethanopterin N-formyltransferase
Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr N-terminal
Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr C-terminal
Aspartate/ornithine carbamoyltransferase
ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL
Heterooligomer of catalytic and regulatory chains.
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Belongs to the eukaryotic ribosomal protein eS6 family.
Belongs to the universal ribosomal protein uS4 family.
Belongs to the universal ribosomal protein uL15 family.
CTP--2, 3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
conserved putative lor/sdh protein from methanococcus maripaludis s2 domain
Aspartate carbamoyltransferase regulatory subunit, C-terminal domain
Aspartate carbamoyltransferase regulatory subunit, N-terminal domain
ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN
Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain
Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain
Involved in allosteric regulation of aspartate carbamoyltransferase.
Contains catalytic and regulatory chains.
Aspartate carbamoyltransferase regulatory subunit N-terminal
Aspartate carbamoyltransferase regulatory subunit C-terminal
DNA-directed RNA polymerase, subunit 2, domain 6
RNA polymerase alpha subunit dimerisation domain
DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2
DNA-directed RNA polymerase subunit beta
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Belongs to the RNA polymerase beta chain family.
DNA-directed RNA polymerase subunit 2 hybrid-binding
N2-METHYLGUANOSINE TRNA METHYLTRANSFERASE
Glycosyl transferase family 1 domain-containing protein
Flagellar motor switch protein FliN-like C-terminal
DNA ligase ATP-dependent C-terminal domain-containing protein
PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO
PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED
Pyridoxal 5'-phosphate synthase subunit PdxT
Pyridoxal 5'-phosphate synthase glutaminase subunit
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.
Belongs to the glutaminase PdxT/SNO family.
METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB
Methyl-accepting chemotaxis protein (MCP) signaling domain
Belongs to the methyl-accepting chemotaxis (MCP) protein family.
Type III-B CRISPR module RAMP protein Cmr6
N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE REDUCTASE, CHLOROPLASTIC-RELATED
N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE REDUCTASE, CHLOROPLASTIC-RELATED-RELATED
N-acetyl-gamma-glutamyl-phosphate reductase
N-acetyl-glutamate semialdehyde dehydrogenase
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
Alpha-2-macroglobulin bait region domain-containing protein
Alpha-galactosidase NEW3 domain-containing protein
Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.
Belongs to the archaeal flagellin family.
LINEARMYCIN RESISTANCE ATP-BINDING PROTEIN LNRL
ORNITHINE TRANSCARBAMYLASE, MITOCHONDRIAL
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
Mg(2+) or Mn(2+) required for ssDNA cleavage activity.
Belongs to the CRISPR-associated exonuclease Cas4 family.
CRISPR-associated endonuclease Cas1, C-terminal domain
CRISPR-associated endonuclease Cas1, N-terminal domain
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
Homodimer, forms a heterotetramer with a Cas2 homodimer.
Belongs to the CRISPR-associated endonuclease Cas1 family.
PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING
FAD/NAD-linked reductases, dimerisation (C-terminal) domain
Pyridine nucleotide-disulfide oxidoreductase
Pyridine nucleotide-disulphide oxidoreductase dimerisation
N-terminal domain of the delta subunit of the F1F0-ATP synthase
ATP SYNTHASE SUBUNIT DELTA, CHLOROPLASTIC
Phosphoadenosine phosphosulfate reductase
EUKARYOTIC TRANSLATION INITIATION FACTOR
EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2
Translation initiation factor 2 beta, aIF2beta, N-terminal domain
Zinc-binding domain of translation initiation factor 2 beta
Translation initiation factor 2 subunit beta
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
Heterotrimer composed of an alpha, a beta and a gamma chain.
S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC
Uroporphyrinogen-III C-methyltransferase
Belongs to the precorrin methyltransferase family.
Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
SHORT CHAIN ISOPRENYL DIPHOSPHATE SYNTHASE
Belongs to the FPP/GGPP synthase family.
S-adenosyl-l-methionine hydroxide adenosyltransferase, N-terminal
Bacterial fluorinating enzyme, C-terminal domain
Bacterial fluorinating enzyme, N-terminal domain
Belongs to the SAM hydrolase / SAM-dependent halogenase family.
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
Eight-cysteine-cluster domain-containing protein
translation initiation factor eif-2b, domain 1
Putative methylthioribose-1-phosphate isomerase
S-methyl-5-thioribose-1-phosphate isomerase
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Response regulatory domain-containing protein
Belongs to the eukaryotic ribosomal protein eL19 family.
SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11
Cell wall-binding repeat 2 family protein
MalT-like TPR region domain-containing protein
ATP-dependent sacrificial sulfur transferase LarE
Belongs to the desulfoferrodoxin family.
Binds the lower part of the 30S subunit head.
Belongs to the universal ribosomal protein uS3 family.
Transposase IS4-like domain-containing protein
OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL
Binds 1 thiamine pyrophosphate per subunit.
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
Binds 2 Mg(2+) or Mn(2+) ions per subunit.
Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
Cell wall-binding repeat-containing protein
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SAMP2)
Belongs to the eukaryotic ribosomal protein eL42 family.
PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE SUBUNIT PURQ
Formylglycinamide ribonucleotide amidotransferase subunit I
Phosphoribosylformylglycinamidine synthase subunit I
NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING
TRNA (CYTOSINE(48)-C(5))-METHYLTRANSFERASE
SAM-dependent tRNA/rRNA cytosine-C5 methylase
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
orc1/cdc6 family replication initiation protein
Involved in regulation of DNA replication.
Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
Belongs to the RNase PH family. Rrp41 subfamily.
ATP-SYNT_AB DOMAIN-CONTAINING PROTEIN-RELATED
C-terminal domain of alpha and beta subunits of F1 ATP synthase
Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.
Belongs to the ATPase alpha/beta chains family.
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Belongs to the eukaryotic ribosomal protein eS31 family.
Hydrogenase maturation nickel metallochaperone HypA
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME
PYRUVATE FORMATE-LYASE-ACTIVATING ENZYME
AmmeMemoRadiSam system radical SAM enzyme
Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
HYPOTHETICAL MEMBRANE PROTEIN, CONSERVED, DUF63 FAMILY
Belongs to the eukaryotic ribosomal protein eL15 family.
Bacterial type II secretion system protein E domain-containing protein
Molybdopterin biosynthesis moea protein, domain 2
Molybdopterin biosynthesis moea protein, domain 3
MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MJ0666-RELATED
Molybdenum cofactor biosynthesis proteins
Molybdopterin molybdenumtransferase MoeA
YVTN repeat-like/Quinoprotein amine dehydrogenase
7-cyano-7-deazaguanine tRNA-ribosyltransferase
Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.
Belongs to the archaeosine tRNA-ribosyltransferase family.
Transglutaminase-like domain-containing protein
Belongs to the eukaryotic ribosomal protein eL31 family.
THREONINE--TRNA LIGASE, CHLOROPLASTIC/MITOCHONDRIAL 2
Belongs to the class-II aminoacyl-tRNA synthetase family.
SULFOPYRUVATE DECARBOXYLASE SUBUNIT ALPHA
Tryptophan synthase beta subunit-like PLP-dependent enzymes
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
Tetramer of two alpha and two beta chains.
Tryptophan synthase beta chain-like PALP
NADH:ubiquinone oxidoreductase, 30kDa subunit
NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL
NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3
NADH:ubiquinone oxidoreductase 30kDa subunit
Glycerophosphoryl diester phosphodiesterase membrane domain-containing protein
PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT
Phosphoribosylformylglycinamidine synthase, linker domain
PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE SUBUNIT PURL
Formylglycinamide ribonucleotide amidotransferase subunit II
Phosphoribosylformylglycinamidine synthase subunit II
Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
Phosphoribosylformylglycinamidine synthase linker
Methyl-accepting transducer domain-containing protein
ANTILISTERIAL BACTERIOCIN SUBTILOSIN BIOSYNTHESIS PROTEIN ALBA
Radical SAM core domain-containing protein
Site-specific DNA-methyltransferase (adenine-specific)
Glycosyltransferase RgtA/B/C/D-like domain-containing protein
Type I PLP-dependent aspartate aminotransferase-like (Major domain)
O-PHOSPHO-L-SERYL-TRNA:CYS-TRNA SYNTHASE
Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
Intracellular proteinase inhibitor BsuPI domain-containing protein
FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER
DUF2080 family transposase-associated protein
tRNA uridine(34) 5-carboxymethylaminomethyl modification radical SAM/GNAT enzyme Elp3
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
Belongs to the universal ribosomal protein uL6 family.
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
Belongs to the type IA topoisomerase family.
O-(5'-phospho-DNA)-tyrosine intermediate
Isopentenyl diphosphate:dimethylallyl diphosphate isomerase
Type 2 isopentenyl diphosphate isomerase
Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
Belongs to the IPP isomerase type 2 family.
DNA-binding protein Tfx superfamily, archaea
Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
Belongs to the pseudouridine synthase TruD family.
Type III-B CRISPR module RAMP protein Cmr1
Carbamoyl-phosphate synthase small subunit, N-terminal domain
CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN
Carbamoyl phosphate synthetase, small subunit N-terminal domain
Carbamoyl-phosphate synthase small chain
Carbamoyl-phosphate synthetase glutamine chain
Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
Carbamoyl-phosphate synthase small subunit N-terminal
pyridoxal 5'-phosphate synthase lyase subunit PdxS
PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED
Pyridoxal 5'-phosphate synthase subunit PdxS
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
In the presence of PdxT, forms a dodecamer of heterodimers.
Schiff-base intermediate with D-ribose 5-phosphate
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase
1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Glycosyl hydrolase family 32 N-terminal domain-containing protein
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.
Assembles at midcell at the inner surface of the cytoplasmic membrane.
Isocitrate/Isopropylmalate dehydrogenase-like
Binds 1 Mg(2+) or Mn(2+) ion per subunit.
SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATA
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
Oligopeptide ABC transporter ATP-binding protein
DNA helicase RuvA subunit, C-terminal domain
Nascent polypeptide-associated complex domain
archaeal-type nascent polypeptide-associated complex protein
Nascent polypeptide-associated complex protein
Contacts the emerging nascent chain on the ribosome.
Homodimer. Interacts with the ribosome. Binds ribosomal RNA.
FlgD/Vpr Ig-like domain-containing protein
Belongs to the V-ATPase V0D/AC39 subunit family.
IS200/IS605 family accessory protein TnpB-like domain
In the C-terminal section; belongs to the transposase 35 family.
Probable transposase IS891/IS1136/IS1341
Ribonuclease Y N-terminal domain-containing protein
HYDROGENASE PROTEIN ASSEMBLY PROTEIN, NICKEL CHAPERONE
NADPH-DEPENDENT 7-CYANO-7-DEAZAGUANINE REDUCTASE
Tetrahydrobiopterin biosynthesis enzymes-like
3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE
Substrate-binding domain of HMG-CoA reductase
3-hydroxy-3-methylglutaryl coenzyme A reductase
Belongs to the HMG-CoA reductase family.
DNA replication complex GINS family protein
Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Glutamine phosphoribosylpyrophosphate amidotransferase
Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3
MucB/RseB N-terminal domain-containing protein
tRNA-guanine(15) transglycosylase-like domain-containing protein
Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
Sulfur carrier protein ThiS sulfurtransferase
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
Composite domain of metallo-dependent hydrolases
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE
Belongs to the thiolase-like superfamily. UPF0219 family.
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED
GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
Belongs to the GatB/GatE family. GatB subfamily.
Hydantoinase A/oxoprolinase domain-containing protein
Homing endonuclease LAGLIDADG domain-containing protein
Belongs to the HAD-like hydrolase superfamily. SerB family.
Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.
Belongs to the PEP-utilizing enzyme family.
Pyruvate phosphate dikinase AMP/ATP-binding
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
Thioredoxin-like fold domain-containing protein
Protein transport protein SEC61 subunit alpha homolog
The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
Putative modulator of DNA gyrase, PmbA/TldD
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
Belongs to the adenosylhomocysteinase family.
S-adenosyl-L-homocysteine hydrolase NAD binding
Belongs to the universal ribosomal protein uS9 family.
Divalent-metal-dependent TIM barrel enzymes
50S RIBOSOMAL PROTEIN L29, CHLOROPLASTIC
60S RIBOSOMAL PROTEIN L35/50S RIBOSOMAL PROTEIN L29
Belongs to the universal ribosomal protein uL29 family.
Belongs to the transcriptional regulator TrmB family.
UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER
Belongs to the eukaryotic ribosomal protein eL34 family.
Aspartate-beta-semialdehyde dehydrogenase
Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
Belongs to the aspartate-semialdehyde dehydrogenase family.
Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.
Belongs to the HAD-like hydrolase superfamily.
Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
EXPORTED CALCIUM-BINDING GLYCOPROTEIN-RELATED
3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
Carbamoyl-phosphate synthetase, large subunit oligomerisation domain
Carbamoyl phosphate synthetase, large subunit connection domain
carbamoyl-phosphate synthase (glutamine-hydrolyzing)
Carbamoyl-phosphate synthetase ammonia chain
Winged helix-turn-helix domain-containing protein
Molybdopterin synthase sulfur carrier subunit
PGF-CTERM sorting domain-containing protein
TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X
Bacterial extracellular solute-binding protein, family 7
C4-dicarboxylate ABC transporter substrate-binding protein
Belongs to the archaeosine synthase type 1 family.
Calcium-transporting ATPase, transmembrane domain
Cation-transporting P-type ATPase C-terminal
Transcription regulator TrmB N-terminal domain-containing protein
Type III-B CRISPR module-associated protein Cmr3
Glycosyltransferase 2-like domain-containing protein
Pyruvoyl-Dependent Histidine Decarboxylase, subunit B
arginine decarboxylase, pyruvoyl-dependent
PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE
Pyruvoyl-dependent histidine and arginine decarboxylases
Pyruvoyl-dependent arginine decarboxylase subunit beta
Pyruvoyl-dependent arginine decarboxylase subunit alpha
Peptidase M10 metallopeptidase domain-containing protein
CDP-alcohol phosphatidyltransferase family protein
RNA polymerase Rpb7-like, N-terminal domain
DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7
N-terminal, heterodimerisation domain of RBP7 (RpoE)
DNA-directed RNA polymerase subunit Rpo7
Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.
Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
Anaerobic ribonucleoside-triphosphate reductase activating protein
MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA
Type III-B CRISPR module RAMP protein Cmr4
DIAMINOPIMELATE DECARBOXYLASE 1, CHLOROPLASTIC-RELATED
Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.
Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
VITAMIN B12-DEPENDENT RIBONUCLEOTIDE REDUCTASE
R1 subunit of ribonucleotide reductase, N-terminal domain
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Belongs to the ribonucleoside diphosphate reductase class-2 family.
Belongs to the ribonucleoside diphosphate reductase large chain family.
Periplasmic copper-binding protein NosD beta helix domain-containing protein
Periplasmic copper-binding protein NosD beta helix
Belongs to the cytidylate kinase family. Type 2 subfamily.
ARSENICAL RESISTANCE OPERON REPRESSOR ARSR-RELATED
Eukaryotic type KH-domain (KH-domain type I)
ASPARAGINE SYNTHETASE (GLUTAMINE-HYDROLYZING)
Putative asparagine synthetase [glutamine-hydrolyzing]
Important for beta-aspartyl-AMP intermediate formation
UDP-N-acetylglucosamine 2-epimerase (Non-hydrolyzing)
PERIPLASMIC PHOSPHATE BINDING COMPONENT OF PHOSPHATE ABC TRANSPORTER
RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER
5-phospho-D-ribosyl alpha-1-diphosphate synthase
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
Ribose-phosphate pyrophosphokinase N-terminal
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III
INDOLEPYRUVATE OXIDOREDUCTASE SUBUNIT IORB
Indolepyruvate ferredoxin oxidoreductase subunit beta
Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
Heterodimer of the IorA and IorB subunits.
Pyruvate/ketoisovalerate oxidoreductase catalytic
POSSIBLE NUCLEASE OF RNASE H FOLD, RUVC/YQGF FAMILY
ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE
ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER
PROTEASOME SUBUNIT ALPHA TYPE-7-1-RELATED
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.
The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL
Alpha-keto-beta-hydroxylacyl reductoisomerase
Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
Belongs to the ketol-acid reductoisomerase family.
Belongs to the group II decarboxylase family.
6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
putative n-type atp pyrophosphatase, domain 2
DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN
AbiEi antitoxin C-terminal domain-containing protein
MOLYBDATE/TUNGSTATE-BINDING PROTEIN WTPA
Tungstate ABC transporter substrate-binding protein WtpA
Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.
Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
tRNA intron endonuclease, N-terminal domain
tRNA-intron endonuclease catalytic domain-like
tRNA-intron endonuclease N-terminal domain-like
sulfide-dependent adenosine diphosphate thiazole synthase
Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
ligand shared between two adjacent protomers
Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.
Proliferating cell nuclear antigen PCNA N-terminal
Proliferating cell nuclear antigen PCNA C-terminal
Resolvase/invertase-type recombinase catalytic
DOD-type homing endonuclease domain-containing protein
Proteasome endopeptidase complex, archaeal, beta subunit
Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.
Belongs to the EF-1-beta/EF-1-delta family.
Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange
ANAEROBIC SULFATASE-MATURATING ENZYME HOMOLOG ASLB-RELATED
Putative peptide-modifying radical SAM/SPASM domain-containing protein
Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.
Belongs to the universal ribosomal protein uL3 family.
Protein kinase domain-containing protein
NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL
Belongs to the complex I 20 kDa subunit family.
NADH:ubiquinone oxidoreductase-like 20kDa subunit
INDOLEPYRUVATE OXIDOREDUCTASE SUBUNIT IORA
Indolepyruvate ferredoxin oxidoreductase subunit alpha
Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
Involved in the binding of tRNA to the ribosomes.
Belongs to the universal ribosomal protein uS10 family.
Probable tRNA pseudouridine synthase domain
PEP-CTERM protein-sorting domain-containing protein
[FEFE] HYDROGENASE MATURASE SUBUNIT HYDE
[FeFe] hydrogenase H-cluster radical SAM maturase HydE
CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5
H/ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1
Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY
PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE
Coenzyme A biosynthesis bifunctional protein CoaBC
DNA/pantothenate metabolism flavoprotein
Phosphopantothenoylcysteine synthetase/decarboxylase
Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
In the C-terminal section; belongs to the PPC synthetase family.
In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
DNA/pantothenate metabolism flavoprotein C-terminal
GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2
IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISH
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
translation elongation factor selb, chain A, domain 4
Belongs to the eukaryotic ribosomal protein eL33 family.
Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.
Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
5-AMINO-6-(5-PHOSPHO-D-RIBITYLAMINO)URACIL PHOSPHATASE YIGB
Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
Catalyzes the attachment of tryptophan to tRNA(Trp).
DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS
DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER
Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
Belongs to the mannose-6-phosphate isomerase type 2 family.
Mannose-6-phosphate isomerase type II C-terminal
CdvA-like coiled-coil domain-containing protein
ATP--dephospho-CoA triphosphoribosyl transferase CitG
Zinc finger/thioredoxin putative domain-containing protein
TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT ALPHA
TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT
Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.
Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
The winged helix domain is involved in binding to DNA in the preinitiation complex.
Probable queuosine precursor transporter
Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.
Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
Homohexamer. Organized in a ring with a central cavity.
Belongs to the peptidase S16 family. Archaeal LonB subfamily.
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
MEMBRANE COMPONENT OF TRANSPORTER-RELATED
Fibronectin type-III domain-containing protein
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
Alanyl-transfer RNA synthetases family profile
Histidine kinase/HSP90-like ATPase domain-containing protein
HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER
Formylmethanofuran dehydrogenase subunit A
60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N
Belongs to the eukaryotic ribosomal protein eL32 family.
DsrC, the gamma subunit of dissimilatory sulfite reductase
Catalyzes the decarboxylation of L-aspartate to produce beta-alanine.
Belongs to the group II decarboxylase family. MfnA subfamily.
Belongs to the eukaryotic ribosomal protein eL40 family.
PYRIDOXAL PHOSPHATE PHOSPHATASE YBHA-RELATED
Glucose-1-phosphate thymidylyltransferase
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE
TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE-RELATED
t(6)A37 threonylcarbamoyladenosine biosynthesis protein Kae1
tRNA threonylcarbamoyladenosine biosynthesis protein Kae1
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.
TRANSCOBALAMIN-1/GASTRIC INTRINSIC FACTOR
Terpenoid cyclases/Protein prenyltransferases
Squalene cyclase C-terminal domain-containing protein
CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR
CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER
Belongs to the aspartate/ornithine carbamoyltransferase superfamily.
Cytochrome-c3 hydrogenase, C-terminal domain
NADH:ubiquinone oxidoreductase-like, 20kDa subunit
NIFE / NIFESE HYDROGENASE SMALL SUBUNIT FAMILY MEMBER
Heterodimer of a large and a small subunit.
Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
N-ACETYLMURAMOYL-L-ALANINE AMIDASE-RELATED
Molybdopterin cofactor biosynthesis C (MoaC) domain
Molybdenum cofactor biosynthesis protein C, MoaC
Probable cyclic pyranopterin monophosphate synthase
Molybdenum cofactor biosynthesis protein C
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
Molybdopterin cofactor biosynthesis C (MoaC)
MOLYBDOPTERIN-GUANINE DINUCLEOTIDE BIOSYNTHESIS ADAPTER PROTEIN
MOLYBDOPTERIN-GUANINE DINUCLEOTIDE BIOSYNTHESIS ADAPTER PROTEIN-RELATED
Molybdopterin-guanine dinucleotide biosynthesis protein B
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
N-acetyltransferase domain-containing protein
Carbamoyl-phosphate synthase large chain
Binds 4 Mg(2+) or Mn(2+) ions per subunit.
Adenine-specific Methyltransferase, Domain 2
Belongs to the N(4)/N(6)-methyltransferase family.
Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.
DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER
REGULATOR OF TELOMERE ELONGATION HELICASE 1
Belongs to the helicase family. RAD3/XPD subfamily.
ACETYL-COA DECARBONYLASE/SYNTHASE COMPLEX SUBUNIT DELTA
CO dehydrogenase/acetyl-CoA synthase delta subunit TIM barrel
TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE
23S rRNA (Uracil(1939)-C(5))-methyltransferase RlmD
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
Peptidase S8/S53 domain-containing protein
SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATC
SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATC, CHLOROPLASTIC-RELATED
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.
Glutamate synthase, alpha subunit, C-terminal domain
TUNGSTEN FORMYLMETHANOFURAN DEHYDROGENASE, SUBUNIT C (FWDC)
TUNGSTEN-CONTAINING FORMYLMETHANOFURAN DEHYDROGENASE 2 SUBUNIT C
Alpha subunit of glutamate synthase, C-terminal domain
Glutamate synthase alpha subunit C-terminal
PROBABLE GENERAL SECRETION PATHWAY PROTEIN D
TYPE IV PILIATION SYSTEM PROTEIN DR_0774-RELATED
Secretin/TonB short N-terminal domain-containing protein
PST FAMILY PREDICTED COLANIC ACID TRANSPORTER
Polysaccharide biosynthesis protein C-terminal domain-containing protein
Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
PHOSPHOMETHYLPYRIMIDINE SYNTHASE, CHLOROPLASTIC
Hydroxymethylpyrimidine phosphate synthase
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
Nucleotidyl transferase AbiEii/AbiGii toxin family protein
Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
Porphobilinogen deaminase, C-terminal domain
Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
Binds 1 dipyrromethane group covalently.
The porphobilinogen subunits are added to the dipyrromethane group.
SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED
Nitrite and sulphite reductase 4Fe-4S domain-like
Nitrite/Sulfite reductase N-terminal domain-like
Dissimilatory-type sulfite reductase subunit beta
MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN B
Molybdenum cofactor biosynthesis protein
Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.
Heterodimer of a large subunit and a small subunit.
Belongs to the archaeal DNA polymerase II family.
DNA polymerase II large subunit DP2 N-terminal
Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
Belongs to the archaeal phosphopantothenate synthetase family.
Restriction endonuclease type IV Mrr domain-containing protein
Bacteriophage SPP1 head-tail adaptor protein
Alpha-L-rhamnosidase six-hairpin glycosidase domain-containing protein
ATP DEPENDENT LON PROTEASE FAMILY MEMBER
PEP-CTERM sorting domain-containing protein
HTH cro/C1-type domain-containing protein
HypC/HybG/HupF family hydrogenase formation chaperone
Transferase(Phosphotransferase) domain 1
WD_REPEATS_REGION DOMAIN-CONTAINING PROTEIN
CYTOKININ RIBOSIDE 5'-MONOPHOSPHATE PHOSPHORIBOHYDROLASE
PYRIMIDINE/PURINE NUCLEOTIDE 5'-MONOPHOSPHATE NUCLEOSIDASE
METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE
Methylated DNA-protein cysteine methyltransferase, C-terminal domain
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
BETA-RIBOFURANOSYLAMINOBENZENE 5'-PHOSPHATE SYNTHASE
Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
Belongs to the beta-RFA-P synthase family.
Belongs to the OMP decarboxylase family. Type 2 subfamily.
HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN
HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HISIE
putative toxin-antitoxin system toxin component, PIN family
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
Belongs to the triosephosphate isomerase family.
Belongs to the eukaryotic ribosomal protein eL43 family.
Protein transport protein Sec61 gamma subunit homolog
Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
DNA POLYMERASE SUBUNIT GAMMA-2, MITOCHONDRIAL
C4-DICARBOXYLATE TRANSPORT SENSOR PROTEIN DCTB
Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3
Belongs to the phosphohexose mutase family.
Alpha-D-phosphohexomutase alpha/beta/alpha
Hybrid sensor histidine kinase/response regulator
DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 1
DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.
Belongs to the eukaryotic ribosomal protein P1/P2 family.
Transposase IS200-like domain-containing protein
Type I-B CRISPR-associated protein Cas7/Cst2/DevR
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
Glycoside-hydrolase family GH114 TIM-barrel domain-containing protein
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
Belongs to the ATP-dependent AMP-binding enzyme family.
EUKARYOTIC PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Heterodimer of two subunits, one of which binds GTP.
Belongs to the eukaryotic release factor 1 family.
RIBOSOMAL_L23EN DOMAIN-CONTAINING PROTEIN
Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
Part of the 50S ribosomal subunit. Contacts protein L29.
Belongs to the universal ribosomal protein uL23 family.
Type I restriction modification DNA specificity domain-containing protein
Non-canonical O-phosphoseryl-tRNA(Cys) synthetase
Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
HYDROGENASE PROTEIN ASSEMBLY PROTEIN HYPD
D-Amino Acid Oxidase, subunit A, domain 2
DIGERANYLGERANYLGLYCEROPHOSPHOLIPID REDUCTASE
RNA 3'-terminal phosphate cyclase domain
RNA 3'-terminal phosphate cyclase, insert domain
RNA 3'-terminal phosphate cyclase, RPTC, insert domain
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
RNA 3'-terminal phosphate cyclase insert
NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE
Belongs to the protein kinase superfamily. BUD32 family.
ACETOLACTATE SYNTHASE SMALL SUBUNIT 2, CHLOROPLASTIC
Acetohydroxy-acid synthase small subunit
Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
Belongs to the acetolactate synthase small subunit family.
Elongation Factor G (Translational Gtpase), domain 3
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
L(+)-TARTRATE DEHYDRATASE SUBUNIT ALPHA-RELATED
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Membrane transport protein MMPL domain-containing protein
Part of the 50S ribosomal subunit. Binds 23S rRNA.
Belongs to the eukaryotic ribosomal protein eL20 family.
Ribosomal protein 50S-L18Ae/60S-L20/60S-L18A
Type II secretion system protein GspE N-terminal
THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED
Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.
Belongs to the threonine synthase family.
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
Belongs to the universal ribosomal protein uS7 family.
D-amino Acid Aminotransferase, subunit A, domain 2
D-aminoacid aminotransferase-like PLP-dependent enzymes
Branched-chain-amino-acid aminotransferase
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
Chitobiase/beta-hexosaminidase domain 2-like
Ribulose bisphosphate carboxylase, large subunit, C-terminal domain
RuBisCO large subunit, N-terminal domain
RIBULOSE BISPHOSPHATE CARBOXYLASE LARGE CHAIN
RuBisCO, large subunit, small (N-terminal) domain
Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.
Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
Belongs to the RuBisCO large chain family. Type III subfamily.
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Ribulose bisphosphate carboxylase large subunit C-terminal
Belongs to the universal ribosomal protein uL10 family.
CRISPR type III-B/RAMP module-associated protein Cmr5
Belongs to the CRISPR system Cmr5 family.
JHP933, nucleotidyltransferase-like core domain
Com family DNA-binding transcriptional regulator
Polymerase nucleotidyl transferase domain-containing protein
mini-chromosome maintenance (MCM) complex, chain A, domain 1
DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER
Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
Type II toxin-antitoxin system RelE/ParE family toxin
C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
Secretion system C-terminal sorting domain-containing protein
Diphthamide biosynthesis methyltransferase
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Belongs to the diphthine synthase family.
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Transcriptional regulatory protein pf0864 domain like
nickel pincer cofactor biosynthesis protein LarC
PYRIDINIUM-3,5-BISTHIOCARBOXYLIC ACID MONONUCLEOTIDE NICKEL INSERTION PROTEIN
BIFUNCTIONAL GLUTAMATE/PROLINE--TRNA LIGASE
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
CRISPR-ASSOCIATED ENDORIBONUCLEASE CAS2 3
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
Homodimer, forms a heterotetramer with a Cas1 homodimer.
Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3
Ribosomal RNA large subunit methyltransferase E
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
Pantetheine-phosphate adenylyltransferase
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
Quinolinate phosphoribosyl transferase, N-terminal domain
NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]
Nicotinate/Quinolinate PRTase C-terminal domain-like
Nicotinate/Quinolinate PRTase N-terminal domain-like
Quinolinate phosphoribosyltransferase [decarboxylating]
Involved in the catabolism of quinolinic acid (QA).
Quinolinate phosphoribosyl transferase N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Thioesterase/thiol ester dehydrase-isomerase
Belongs to the thioesterase PaaI family.
Binds 16S rRNA, required for the assembly of 30S particles.
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Binds directly to 23S rRNA. Probably involved in E site tRNA release.
Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.
Belongs to the universal ribosomal protein uL1 family.
PPM-type phosphatase domain-containing protein
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
Lysine tRNA ligase, stem contact fold domain
An anticodon-binding domain of class I aminoacyl-tRNA synthetases
Aminoacyl-tRNA synthetase class I anticodon-binding
DNA REPAIR AND RECOMBINATION PROTEIN RADB
RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER
Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.
Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE/SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC
SDH C-terminal domain-containing protein
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL
Cytochrome c7-like domain-containing protein
DNA methylase N-4/N-6 domain-containing protein
Arginyl tRNA synthetase N-terminal domain
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain
Type II toxin-antitoxin system MqsA family antitoxin
PHOSPHORIBOSYLAMINE--GLYCINE LIGASE, CHLOROPLASTIC
TUNGSTEN-CONTAINING FORMYLMETHANOFURAN DEHYDROGENASE 2 SUBUNIT B
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Belongs to the ketopantoate reductase family.
Belongs to the eukaryotic ribosomal protein eS24 family.
Formate dehydrogenase/DMSO reductase domain
FLAGELLAR BIOSYNTHESIS PROTEIN FLHA-RELATED
FLAGELLAR EXPORT PROTEIN, MEMBRANE FLHA SUBUNIT-RELATED
EscV/YscV/HrcV family type III secretion system export apparatus protein
Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
Proliferating cell nuclear antigen (Pcna)
Thiamine pyrophosphate enzyme TPP-binding
L-GLUTAMINE--4-(METHYLSULFANYL)-2-OXOBUTANOATE AMINOTRANSFERASE
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
EUKARYOTIC TRANSLATION INITIATION FACTOR 5A
TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER
Functions by promoting the formation of the first peptide bond.
Translation elongation factor IF5A C-terminal
Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
Part of the 50S ribosomal subunit. Probably part of the RNase P complex.
Belongs to the eukaryotic ribosomal protein eL8 family.
Glycosyl hydrolase-like 10 domain-containing protein
Cysteine-tRNA ligase, C-terminal anti-codon recognition domain
Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.
TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER
Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2
N-acetyl-L-glutamate 5-phosphotransferase
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
Belongs to the acetylglutamate kinase family. ArgB subfamily.
CDC48 N-terminal subdomain domain-containing protein
Dihydromethanopterin reductase (Acceptor)
EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER
EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED
Translation initiation factor 2 subunit gamma
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
Tape measure protein N-terminal domain-containing protein
S-ADENOSYLMETHIONINE:TRNA RIBOSYLTRANSFERASE-ISOMERASE
tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA
Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE
UDP-glucose--hexose-1-phosphate uridylyltransferase
Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
Galactose-1-phosphate uridyl transferase N-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Belongs to the eukaryotic ribosomal protein eL21 family.
Archaeal tRNA CCA-adding enzyme catalytic domain
CCA tRNA nucleotidyltransferase, domain 2
Poly(A) polymerase predicted RNA binding domain
PAP/Archaeal CCA-adding enzyme, C-terminal domain
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
tRNA nucleotidyltransferase substrate binding
RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE C
Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
Pyrimidine nucleoside phosphorylase-like, C-terminal domain
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
Pyrimidine nucleoside phosphorylase C-terminal domain
Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
Pyrimidine nucleoside phosphorylase C-terminal
RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.
TIGR03986 family CRISPR-associated RAMP protein
CRISPR SYSTEM ENDORIBONUCLEASE CSX1-RELATED
TIGR01897 family CRISPR-associated protein
LIPOPOLYSACCHARIDE 1,2-N-ACETYLGLUCOSAMINETRANSFERASE-RELATED
ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED
MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1
MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A
Molybdenum cofactor biosynthesis protein A
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
Belongs to the radical SAM superfamily. MoaA family.
Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
Heterodimer of a small subunit (PriS) and a large subunit (PriL).
Belongs to the eukaryotic-type primase small subunit family.
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED
BIFUNCTIONAL UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE/N-ACETYLMANNOSAMINE KINASE
Catalyzes the conversion of dihydroorotate to orotate.
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
Reaction proceeds via a cis-phosphoenolate intermediate.
Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
Bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs), Chain M, domain 3
Bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs), Chain M, domain 5
Carbon monoxide dehydrogenase alpha subunit. Chain D, domain 4
ACETYL-COA DECARBONYLASE/SYNTHASE COMPLEX SUBUNIT BETA 2
Acetyl-CoA decarbonylase/synthase complex subunit beta
Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).
Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
CO dehydrogenase/acetyl-CoA synthase complex beta subunit C-terminal
GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING
GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)
Vitamin K epoxide reductase domain-containing protein
V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A
N-terminal domain of alpha and beta subunits of F1 ATP synthase
Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.
HISTIDINE--TRNA LIGASE, MITOCHONDRIAL-RELATED
Signal recognition particle SRP54, nucleotide-binding domain
SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA
Domain of the SRP/SRP receptor G-proteins
Signal recognition particle receptor FtsY
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.
Belongs to the GTP-binding SRP family. FtsY subfamily.
GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE
GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE 1, CHLOROPLASTIC-RELATED
Glutamate-1-semialdehyde aminotransferase
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
GMP synthase [glutamine-hydrolyzing] subunit A
Translation initiation factor IF-2 subunit gamma
Belongs to the eukaryotic ribosomal protein eL30 family.
Belongs to the universal ribosomal protein uL18 family.
Belongs to the SIS family. PHI subfamily.
Flagellar hook-associated protein 2 C-terminal domain-containing protein
Methenyltetrahydromethanopterin cyclohydrolase
Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-H(4)MPT.
5-AMINO-6-(D-RIBITYLAMINO)URACIL--L-TYROSINE 4-HYDROXYPHENYL TRANSFERASE
Belongs to the eukaryotic ribosomal protein eL18 family.
GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL
Glutamyl-tRNA(Gln) amidotransferase subunit A
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Belongs to the amidase family. GatA subfamily.
IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF
IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H
Imidazole glycerol phosphate synthase subunit HisF
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
Ligand-binding domain in the NO signalling and Golgi transport
Metanogen output domain-containing protein
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
Belongs to the universal ribosomal protein uL13 family.
ABC-TYPE MULTIDRUG TRANSPORT SYSTEM, PERMEASE COMPONENT
Belongs to the eukaryotic ribosomal protein eS4 family.
4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL
Thymidylate synthase-complementing protein Thy1
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
Belongs to the thymidylate synthase ThyX family.
Involved in ionization of N3 of dUMP, leading to its activation
ligand shared between neighboring subunits
ABC transmembrane type-2 domain-containing protein
GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT E
Glu-tRNA(Gln) amidotransferase GatDE subunit E
Photosynthesis system II assembly factor Ycf48/Hcf136-like domain-containing protein
Anaphase-promoting complex subunit 4 WD40 domain-containing protein
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
With S5 and S12 plays an important role in translational accuracy.
Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
Belongs to the universal ribosomal protein uS8 family.
3-carboxy-cis,cis-mucoante lactonizing enzyme
DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED
OLIGOPEPTIDE/DIPEPTIDE ABC TRANSPORTER, ATPASE SUBUNIT
HOMOLOGY TO DEATH-ON-CURING PROTEIN OF PHAGE P1
Phosphoribosylaminoimidazole-succinocarboxamide synthase
Belongs to the SAICAR synthetase family.
RsbT co-antagonist protein RsbRD N-terminal domain-containing protein
C4-DICARBOXYLATE TRAP TRANSPORTER LARGE PERMEASE PROTEIN DCTM
SIALIC ACID TRAP TRANSPORTER PERMEASE PROTEIN SIAT-RELATED
C4-dicarboxylate ABC transporter permease
TRAP C4-dicarboxylate transport system permease DctM subunit
Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)
DNA-(apurinic or apyrimidinic site) lyase
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
FIMBRIAL ASSEMBLY PROTEIN PILO-LIKE PROTEIN-RELATED
TYPE IV PILUS INNER MEMBRANE COMPONENT PILO
LPXTG cell wall anchor domain-containing protein
CO dehydrogenase/acetyl-CoA synthase complex subunit epsilon
4-HYDROXY-TETRAHYDRODIPICOLINATE SYNTHASE
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
SAM-dependent methyltransferase TRM5/TYW2-type
Acetolactate synthase small subunit C-terminal
Glutamine amidotransferase type-2 domain-containing protein
Aminoacyl-tRNA synthetase class II (G/ P/ S/T)
inorganic pyrophosphatase (n-terminal core)
BIFUNCTIONAL OLIGORIBONUCLEASE AND PAP PHOSPHATASE NRNA
Rhodanese/Cell cycle control phosphatase
5,10-methylenetetrahydrofolate reductase
2-METHYL-6-PHYTYL-1,4-HYDROQUINONE METHYLTRANSFERASE, CHLOROPLASTIC
Methyltransferase type 11 domain-containing protein
4Fe4S-binding SPASM domain-containing protein
Bacterial exopeptidase dimerisation domain
Peptidase M20 dimerisation domain-containing protein
DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08740)-RELATED
Xylose isomerase-like TIM barrel domain-containing protein
3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE
SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE RECJ
NAD(P)H-DEPENDENT FMN-CONTAINING OXIDOREDUCTASE YWQN-RELATED
Dinitrogenase iron-molybdenum cofactor biosynthesis domain
Dinitrogenase iron-molybdenum cofactor biosynthesis
DNA topoisomerase VI subunit B transducer
Belongs to the carbohydrate kinase PfkB family.
AP_ENDONUC_2 DOMAIN-CONTAINING PROTEIN-RELATED
ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV
Aldehyde Ferredoxin Oxidoreductase Protein, subunit A, domain 2
Aldehyde Ferredoxin Oxidoreductase Protein, subunit A, domain 3
TUNGSTEN-CONTAINING ALDEHYDE FERREDOXIN OXIDOREDUCTASE
Aldehyde ferredoxin oxidoreductase, C-terminal domains
Aldehyde ferredoxin oxidoreductase C-terminal
Histidine-containing phosphotransfer domain, HPT domain
MFS general substrate transporter like domains
INTEGRAL MEMBRANE TRANSPORT PROTEIN-RELATED
Belongs to the CitM (TC 2.A.11) transporter family.
Phosphoribosyltransferase domain-containing protein
CYTOCHROME C-TYPE BIOGENESIS PROTEIN CCMF
Cytochrome c assembly protein domain-containing protein
Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE SYNTHASE THI11-RELATED
THIAMINE BIOSYNTHESIS PROTEIN HI_0357-RELATED
Solute-binding protein family 3/N-terminal
DINITROGENASE IRON-MOLYBDENUM COFACTOR PROTEIN-RELATED
Dinitrogenase iron-molybdenum cofactor biosynthesis protein
ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED
TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN
TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN-RELATED
Calcineurin-like phosphoesterase domain-containing protein
Antitoxin component of a type II toxin-antitoxin (TA) system.
IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7
Belongs to the imidazoleglycerol-phosphate dehydratase family.
MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE
PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE
4FE-4S CLUSTER CONTAINING PARA FAMILY ATPASE PROTEIN
Multidrug efflux transporter AcrB transmembrane domain
Part of the protein translocation apparatus. Forms a complex with SecF.
Belongs to the SecD/SecF family. SecD subfamily.
GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB
Polymerase beta nucleotidyltransferase domain-containing protein
Rad50/SbcC-type AAA domain-containing protein
Trafficking protein particle complex subunit 3
GHMP kinase N-terminal domain-containing protein
Rad21/Rec8-like protein C-terminal eukaryotic domain-containing protein
Rad21/Rec8-like protein C-terminal eukaryotic
Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA
DIGERANYLGERANYLGLYCERYL PHOSPHATE SYNTHASE
(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase
Geranylgeranylglycerol-phosphate geranylgeranyltransferase
Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
AMIDOHYDRO-REL DOMAIN-CONTAINING PROTEIN
5-methylthioadenosine/S-adenosylhomocysteine deaminase
Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
Belongs to the helicase family. RAD25/XPB subfamily.
Type II secretion system (T2SS), domain F
TYPE II SECRETION SYSTEM PROTEIN F-RELATED
Type II secretion system F family protein
Peptidoglycan binding-like domain-containing protein
Helix-turn-helix type 11 domain-containing protein
EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1
Translation initiation factor IF-2 subunit alpha
7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN DIMETHYLTRANSFERASE
Nucleoside diphosphate kinase-like domain
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Hydantoinase B/oxoprolinase domain-containing protein
BRANCHED-CHAIN AMINO ACID TRANSPORT ATP-BINDING PROTEIN LIVG-RELATED
CONSERVED COMPONENT OF ABC TRANSPORTER FOR NATURAL AMINO ACIDS-RELATED
Branched-chain amino acid ATP-binding cassette transporter C-terminal
CARBON-MONOXIDE DEHYDROGENASE ACCESSORY PROTEIN
RRNA N6-ADENOSINE-METHYLTRANSFERASE METTL5
N(4)-bis(aminopropyl)spermidine synthase C-terminal
Cell growth inhibitor/plasmid maintenance toxic component
Type II toxin-antitoxin system PemK/MazF family toxin
B3/B4 tRNA-binding domain-containing protein
7-HYDROXYMETHYL CHLOROPHYLL A REDUCTASE, CHLOROPLASTIC
ATP-BINDING CASSETTE SUB-FAMILY E MEMBER 1
Ribosome biogenesis/translation initiation ATPase RLI
PROTEIN-GLUTAMATE METHYLESTERASE/PROTEIN-GLUTAMINE GLUTAMINASE
Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.
Multidrug resistance efflux transporter EmrE
TYPE-1 RESTRICTION ENZYME ECOKI SPECIFICITY PROTEIN
TYPE-1 RESTRICTION ENZYME MJAXIP SPECIFICITY PROTEIN
Belongs to the type-I restriction system S methylase family.
Type I restriction modification DNA specificity
Probable brix-domain ribosomal biogenesis protein
ANAEROBIC GLYCEROL-3-PHOSPHATE DEHYDROGENASE SUBUNIT A
FAD dependent oxidoreductase domain-containing protein
Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
BRANCHED-CHAIN AMINO ACID TRANSPORT PERMEASE PROTEIN LIVH-RELATED
BRANCHED-CHAIN AMINO ACID TRANSPORT SYSTEM PERMEASE PROTEIN LIVH
Branched-chain amino acid ABC transporter permease
OSMOSENSING HISTIDINE PROTEIN KINASE SLN1
CheC-like protein domain-containing protein
VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR
UDP-N-acetylglucosamine 2-epimerase domain-containing protein
FORMATE DEHYDROGENASE, NITRATE-INDUCIBLE, MAJOR SUBUNIT
4Fe-4S Mo/W bis-MGD-type domain-containing protein
TRNA(PHE) (4-DEMETHYLWYOSINE(37)-C(7)) AMINOCARBOXYPROPYLTRANSFERASE
Class I SAM-dependent methyltransferase family protein
METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN
METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G07630)
Dinitrogenase iron-molybdenum cofactor biosynthesis domain-containing protein
Aminodeoxychorismate synthase, component I
ABC-type transport auxiliary lipoprotein component
paralog of FGE (formylglycine-generating enzyme)
Sulfatase-modifying factor enzyme domain-containing protein
Adenine nucleotide alpha hydrolase family protein
METALLO-BETA-LACTAMASE DOMAIN-CONTAINING
Nucleotidyltransferase domain-containing protein
FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD
NADH:ubiquinone/plastoquinone oxidoreductase, chain 3
NAD(P)H-quinone oxidoreductase subunit 3
Belongs to the complex I subunit 3 family.
Aminotransferase class I/classII domain-containing protein
Tubulin/FtsZ GTPase domain-containing protein
HTH-TYPE TRANSCRIPTIONAL REGULATOR MJ1563-RELATED
HTH-TYPE TRANSCRIPTIONAL REGULATOR YVAV-RELATED
THREONYL AND ALANYL TRNA SYNTHETASE SECOND ADDITIONAL DOMAIN-CONTAINING PROTEIN
COLANIC ACID BIOSYNTHESIS GLYCOSYL TRANSFERASE WCAI-RELATED
Glycosyltransferase subfamily 4-like N-terminal domain-containing protein
Leucine Aminopeptidase, subunit E, domain 1
GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED
Geranylgeranylglyceryl/heptaprenylglyceryl phosphate synthase
Adenine deaminase C-terminal domain-containing protein
DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5
DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER
DNA-directed RNA polymerase subunit Rpo10
Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
PROTEIN-GLUTAMATE METHYLESTERASE/PROTEIN-GLUTAMINE GLUTAMINASE 1
Formylmethanofuran dehydrogenase subunit E
Asparagine synthetase domain-containing protein
TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE
TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE, MITOCHONDRIAL
NTP pyrophosphohydrolase MazG putative catalytic core
LONG-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HIS7
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
Transmembrane di-heme cytochromes, Chain C
NI/FE-HYDROGENASE 1 B-TYPE CYTOCHROME SUBUNIT
NI/FE-HYDROGENASE 1 B-TYPE CYTOCHROME SUBUNIT-RELATED
Cytochrome b561 bacterial/Ni-hydrogenase domain-containing protein
Cytochrome b561 bacterial/Ni-hydrogenase
Toxic component of a toxin-antitoxin (TA) system. An RNase.
Belongs to the PINc/VapC protein family.
Lon proteolytic domain-containing protein
ATP-DEPENDENT HELICASE LHR-RELATED-RELATED
Dehydroquinate synthase-like - alpha domain
Glycerol-1-phosphate dehydrogenase [NAD(P)+]
Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
Belongs to the glycerol-1-phosphate dehydrogenase family.
NAD-dependent epimerase/dehydratase domain-containing protein
POLYNUCLEOTIDYL TRANSFERASE, RIBONUCLEASE H-LIKE SUPERFAMILY PROTEIN
Nucleotidyltransferase substrate binding subunit/domain
5-FORMAMINOIMIDAZOLE-4-CARBOXAMIDE-1-(BETA)-D-RIBOFURANOSYL 5'-MONOPHOSPHATE SYNTHETASE
5-FORMAMINOIMIDAZOLE-4-CARBOXAMIDE-1-(BETA)-D-RIBOFURANOSYL 5'-MONOPHOSPHATE SYNTHETASE-RELATED
5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate--formate ligase
Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.
Type II toxin-antitoxin system HicB family antitoxin
HicB-like antitoxin of toxin-antitoxin system
Alpha-glycerophosphate oxidase, cap domain
Alpha-glycerophosphate oxidase C-terminal
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
Ribosomal RNA adenine methylase transferase N-terminal
Major facilitator superfamily (MFS) profile
MOLYBDENUM TRANSPORT SYSTEM PERMEASE PROTEIN MODB
5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE-RELATED
METHENYLTETRAHYDROFOLATE SYNTHASE DOMAIN-CONTAINING PROTEIN
Belongs to the eIF-2B alpha/beta/delta subunits family.
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding domain-containing protein
Signal recognition particle, SRP19-like subunit
SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN
SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.
GLYCINE CLEAVAGE SYSTEM H PROTEIN, MITOCHONDRIAL
Belongs to the archaeal riboflavin kinase family.
COB--COM HETERODISULFIDE REDUCTASE SUBUNIT B 1
Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
Belongs to the small heat shock protein (HSP20) family.
Glycosyl hydrolase family 13 catalytic domain-containing protein
UPF0173 METAL-DEPENDENT HYDROLASE MJ1163-RELATED
THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
Homodecamer. Pentamer of dimers that assemble into a ring structure.
The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
Belongs to the peroxiredoxin family. Prx6 subfamily.
Cysteine sulfenic acid (-SOH) intermediate
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Interchain (with Cys-211); in linked form
Interchain (with Cys-50); in linked form
Signal recognition particle, SRP54 subunit, M-domain
SIGNAL RECOGNITION PARTICLE 54 KDA PROTEIN
SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
The SRP-RNC complex is targeted to the cytoplasmic membrane.
Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
Belongs to the GTP-binding SRP family. SRP54 subfamily.
Signal recognition particle SRP54 helical bundle
ALIPHATIC SULFONATES IMPORT ATP-BINDING PROTEIN SSUB
TAURINE IMPORT ATP-BINDING PROTEIN-RELATED
DUF521 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00490)
Aconitase X catalytic domain-containing protein
Maltogenic Amylase C-terminal domain-containing protein
FERREDOXIN SUBUNIT OF PYRUVATE:FLAVODOXIN OXIDOREDUCTASE-RELATED
Tyr recombinase domain-containing protein
POLY-BETA-1,6-N-ACETYL-D-GLUCOSAMINE SYNTHASE
ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1
DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE
DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1
5-METHYLCYTOSINE-SPECIFIC RESTRICTION ENZYME B
ATPase dynein-related AAA domain-containing protein
Nmd3 N-terminal domain-containing protein
General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
Aldehyde ferredoxin oxidoreductase, N-terminal domain
Aldehyde ferredoxin oxidoreductase N-terminal
CONSERVED HYPOTHETICAL CHEMOTAXIS PROTEIN
Protein-glutamate O-methyltransferase CheR
UPF0173 METAL-DEPENDENT HYDROLASE TM_1162
UPF0173 metal-dependent hydrolase DRN95_04970
Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase GatCAB subunit B
Aspartyl/Glutamyl-tRNA(Gln) amidotransferase subunit B/E catalytic
NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL
NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT
Belongs to the complex I 49 kDa subunit family.
DNA-DIRECTED RNA POLYMERASE, SUBUNIT F (RPOF)
DNA-directed RNA polymerase subunit Rpo4
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.
Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
MOLYBDENUM COFACTOR GUANYLYLTRANSFERASE-RELATED
Probable molybdenum cofactor guanylyltransferase
Molybdopterin-guanine dinucleotide synthase
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
Part of the protein translocation apparatus. Forms a complex with SecD.
Belongs to the SecD/SecF family. SecF subfamily.
ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2
DTDP-4-AMINO-4,6-DIDEOXYGALACTOSE TRANSAMINASE
Glutamine--scyllo-inositol aminotransferase
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
Aspartate/glutamate/uridylate kinase domain-containing protein
Putative HTH-type transcriptional regulatory protein DRN95_05715
Helicase HerA central domain-containing protein
CoB--CoM heterodisulfide reductase subunit B
ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN
PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED
MEIOTIC RECOMBINATION PROTEIN DMC1/LIM15 HOMOLOG
DNA repair and recombination protein RadA
Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
Belongs to the eukaryotic RecA-like protein family.
Coenzyme F420 hydrogenase/dehydrogenase beta subunit C-terminal domain-containing protein
Coenzyme F420 hydrogenase/dehydrogenase beta subunit C-terminal
Cytochrome b/b6 N-terminal region profile domain-containing protein
Cytochrome b/b6 N-terminal region profile
ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINE O-ACYLTRANSFERASE
MAJOR FACILITATOR SUPERFAMILY TRANSPORTER
Major facilitator superfamily (MFS) profile domain-containing protein
Glycosyl transferase family 3 N-terminal
Class II aldolase/adducin N-terminal domain
3-OXO-TETRONATE 4-PHOSPHATE DECARBOXYLASE-RELATED
Belongs to the archaeal adenylate kinase family.
MCM N-terminal domain-containing protein
Twin-arginine translocase TatA/TatE family subunit
1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase
Belongs to the myo-inositol 1-phosphate synthase family.
Myo-inositol-1-phosphate synthase GAPDH-like
Type IV secretion system coupling protein TraD DNA-binding domain-containing protein
Type IV secretion system coupling protein TraD DNA-binding
N6 adenine-specific DNA methyltransferase N-terminal
S-adenosylmethionine synthetase, C-terminal domain
S-adenosylmethionine synthetase, N-terminal domain
ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]
Flagellar FlhF biosynthesis protein, N domain
Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.
ZINC-RIBBON RNA-BINDING PROTEIN INVOLVED IN TRANSLATION-RELATED
Small zinc finger protein HVO-2753-like zinc-binding pocket
D-MALATE DEHYDROGENASE [DECARBOXYLATING]
PHOSPHATE TRANSPORT SYSTEM PERMEASE PROTEIN PST
PHOSPHATE TRANSPORT SYSTEM PERMEASE PROTEIN PSTC
Phosphate ABC transporter permease subunit PstC
ANAEROBIC NITRIC OXIDE REDUCTASE FLAVORUBREDOXIN
Flavodoxin-like domain-containing protein
ABC TRANSPORTER I FAMILY MEMBER 6, CHLOROPLASTIC
Pyruvate/ketoisovalerate oxidoreductase catalytic domain-containing protein
FORMATE DEHYDROGENASE, NITRATE-INDUCIBLE, CYTOCHROME B556 FDN SUBUNIT
DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2
DNA-directed RNA polymerase subunit Rpo6
Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
CBS DOMAIN-CONTAINING PROTEIN CBSX2, CHLOROPLASTIC
L-ASPARTATE SEMIALDEHYDE SULFURTRANSFERASE
LATE ENDOSOMAL/LYSOSOMAL MP1 INTERACTING PROTEIN
Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
ATPASE_AAA_CORE DOMAIN-CONTAINING PROTEIN
ATP-dependent DNA helicase RecG C-terminal
OB FOLD NUCLEIC ACID BINDING PROTEIN-RELATED
1,4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE
UBIA PRENYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1
Carbon monoxide dehydrogenase alpha subunit. Chain M, domain 1
ACETYL-COA DECARBONYLASE/SYNTHASE COMPLEX SUBUNIT ALPHA
RecA family profile 1 domain-containing protein
Magnesium chelatase subunit I, C-Terminal domain
CHEMORECEPTOR GLUTAMINE DEAMIDASE CHED-RELATED
CNF1/YfiH-like putative cysteine hydrolases
Probable chemoreceptor glutamine deamidase CheD
Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.
FERREDOXIN:COB-COM HETERODISULFIDE REDUCTASE SUBUNIT C
IRON-SULFUR-BINDING OXIDOREDUCTASE FADF-RELATED-RELATED
PHOSPHATE REGULATORY PROTEIN-LIKE PROTEIN
PHOSPHATE-SPECIFIC TRANSPORT SYSTEM ACCESSORY PROTEIN PHOU
Gamma-glutamylcyclotransferase AIG2-like domain-containing protein
Gamma-glutamylcyclotransferase AIG2-like
GLYCO_HYDRO_42 DOMAIN-CONTAINING PROTEIN
Asl1-like glycosyl hydrolase catalytic domain-containing protein
HIGH-AFFINITY BRANCHED-CHAIN AMINO ACID TRANSPORT ATP-BINDING PROTEIN LIVF
Peptidase A24A-predicted C-terminal archaea
NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58
Reverse gyrase zinc finger domain-containing protein
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED
DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
Belongs to the helicase family. Hel308 subfamily.
MAGNESIUM PROTOPORPHYRIN IX METHYLTRANSFERASE, CHLOROPLASTIC
BRANCHED-CHAIN AMINO ACID TRANSPORT ATP-BINDING PROTEIN LIVF-RELATED
Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
Aspartate dehydrogenase domain-containing protein
Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.
Belongs to the GHMP kinase family. PoK subfamily.
Iron dependent repressor, metal binding and dimerisation domain
IRON (METAL) DEPENDENT REPRESSOR, DTXR FAMILY
Iron-dependent repressor protein, dimerization domain
Metal-dependent transcriptional regulator
Phosphoglycerate kinase, N-terminal domain
PHOSPHOGLYCERATE KINASE 1, CHLOROPLASTIC-RELATED
Belongs to the phosphoglycerate kinase family.
Peptidase C14 caspase domain-containing protein
MEMBRANE TRANSPORTER PROTEIN MJ0441-RELATED
MEMBRANE TRANSPORTER PROTEIN YTNM-RELATED
Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
CANCER-RELATED NUCLEOSIDE-TRIPHOSPHATASE
Nucleoside triphosphate phosphohydrolase
Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.
AB hydrolase-1 domain-containing protein
UNDECAPRENYL-PHOSPHATE 4-DEOXY-4-FORMAMIDO-L-ARABINOSE TRANSFERASE-RELATED
MEMBRANE TRANSPORTER PROTEIN HI_0806-RELATED
2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE
Amidohydrolase-related domain-containing protein
Purple acid phosphatase N-terminal domain-containing protein
DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1
DNA-directed RNA polymerase subunit Rpo5
Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
RNA polymerase subunit H/Rpb5 C-terminal
Belongs to the universal ribosomal protein uS2 family.
SPERMIDINE/PUTRESCINE IMPORT ATP-BINDING PROTEIN POTA
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ
ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ, MITOCHONDRIAL
TRK SYSTEM POTASSIUM UPTAKE PROTEIN TRKG-RELATED
FLAGELLA-RELATED PROTEIN E-RELATED-RELATED
Archaeal flagella protein FlaD/E domain-containing protein
TRNA(ILE2) 2-AGMATINYLCYTIDINE SYNTHETASE TIAS
ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
F420-dependent methylenetetrahydromethanopterin dehydrogenase (MTD)
F420-dependent methylenetetrahydromethanopterin dehydrogenase
Coenzyme F420-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase
Catalyzes the oxidation of methylene-H(4)MPT to methenyl-H(4)MPT(+).
Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
AMINO-ACID METABOLITE EFFLUX PUMP-RELATED
NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL
VapC toxin family PIN domain ribonuclease
3',5'-CYCLIC ADENOSINE MONOPHOSPHATE PHOSPHODIESTERASE CPDA
Type II toxin-antitoxin system VapC family toxin
2-isopropylmalate synthase LeuA allosteric (dimerisation)
MobA-like NTP transferase domain-containing protein
F1F0 ATP synthase subunit B, membrane domain
ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED
Belongs to the V-ATPase E subunit family.
NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ
DNA-directed RNA polymerase M/15kDa subunit domain-containing protein
DNA-directed RNA polymerase M/15kDa subunit
PurM-like C-terminal domain-containing protein
Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.
Belongs to the DNA polymerase delta/II small subunit family.
DNA polymerase alpha/delta/epsilon subunit B
6-oxocyclohex-1-ene-1-carbonyl-CoA hydratase
PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE CATALYTIC SUBUNIT
5-(Carboxyamino)imidazole ribonucleotide mutase
NADH-quinone oxidoreductase subunit NuoH
Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase
C-terminal domain of RNA polymerase alpha subunit
Belongs to the LysR transcriptional regulatory family.
Outer membrane lipoprotein BamD-like domain-containing protein
PROTEIN ADENYLYLTRANSFERASE MJ0128-RELATED
TRANSCRIPTIONAL REGULATOR PROTEIN-LIKE PROTEIN
4Fe-4S dicluster domain-containing protein
Glycoside hydrolase family 38, central domain
Families 57/38 glycoside transferase middle domain
Glycoside hydrolase family 38 central domain-containing protein
4-vinyl reductase 4VR domain-containing protein
RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE M
OCTANOYL-[GCVH]:PROTEIN N-OCTANOYLTRANSFERASE
Translation elongation factor-like protein
AMINO ACID ABC TRANSPORTER PERMEASE PROTEIN
HIGH-AFFINITY BRANCHED-CHAIN AMINO ACID TRANSPORT SYSTEM PERMEASE
SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL
Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Plays an important role in substrate specificity
Gfo/Idh/MocA-like oxidoreductase N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
60S ribosome subunit biogenesis protein NIP7 pre-PUA
Cytochrome b/b6 domain-containing protein
F420-non-reducing hydrogenase iron-sulfur subunit D domain-containing protein
F420-non-reducing hydrogenase iron-sulfur subunit D
PD-(D/E)XK endonuclease-like domain-containing protein
UNDECAPRENYL-PHOSPHATE ALPHA-N-ACETYLGLUCOSAMINYL 1-PHOSPHATE TRANSFERASE
Resolvase/invertase-type recombinase catalytic domain-containing protein
Carbohydrate-binding domain-containing protein
NICKEL IMPORT SYSTEM PERMEASE PROTEIN NIKC
OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN APPC
Tetrapyrrole biosynthesis uroporphyrinogen III synthase domain-containing protein
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Metallo-beta-lactamase domain-containing protein
Argininosuccinate synthetase, chain A, domain 2
Argininosuccinate synthetase, C-terminal domain
Carbohydrate kinase PfkB domain-containing protein
CHEMOTAXIS SENSOR HISTIDINE KINASE-RELATED
RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain
Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.
BRANCHED-CHAIN AMINO ACID TRANSPORT PERMEASE PROTEIN LIVM-RELATED
Fumarylacetoacetase-like, C-terminal domain
FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A
FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A-RELATED
2-hydroxyhepta-2,4-diene-1,7-dioate isomerase
Belongs to the V-ATPase proteolipid subunit family.
Rhomboid family intramembrane serine protease
Probable glycine cleavage system H protein
The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
The glycine cleavage system is composed of four proteins: P, T, L and H.
ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3
Activating enzymes of the ubiquitin-like proteins
PERIPLASMIC BINDING COMPONENT OF ABC TRANSPORTER
Peptide ABC transporter substrate-binding protein
Belongs to the bacterial solute-binding protein 5 family.
ZINC METALLOPROTEASE EGY1, CHLOROPLASTIC-RELATED
YeiH family putative sulfate export transporter
Aspartate carbamoyltransferase regulatory subunit
Uncharacterised protein PF01937, DUF89, domain 1
Uncharacterised protein PF01937, DUF89, domain 2
Uncharacterised protein PF01937, DUF89, domain 3
Damage-control phosphatase ARMT1-like metal-binding domain-containing protein
Damage-control phosphatase ARMT1-like metal-binding
Bifunctional IPC transferase and DIPP synthase
In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family.
In the N-terminal section; belongs to the MobA family.
PYRUVATE FORMATE-LYASE ACTIVATING ENZYME HOMOLOG
ACETYL-COA DECARBONYLASE/SYNTHASE COMPLEX SUBUNIT GAMMA
5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase
Corrinoid/iron-sulfur component large subunit
Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).
Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
Belongs to the V-ATPase 116 kDa subunit family.
ABC TRANSPORTER PERMEASE PROTEIN MJ0413-RELATED
ALKANE SULFONATE ABC TRANSPORTER-RELATED, MEMBRANE SUBUNIT
Glutamyl-tRNA reductase, N-terminal domain
Glutamyl tRNA-reductase catalytic, N-terminal domain
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.
During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
Belongs to the glutamyl-tRNA reductase family.
A/G-SPECIFIC ADENINE GLYCOSYLASE/ENDONUCLEASE III
Conserved hypothetical protein from pyrococcus furiosus pfu- 392566-001, ParB domain
LuxC is the fatty acid reductase enzyme responsible for synthesis of the aldehyde substrate for the luminescent reaction catalyzed by luciferase.
Nucleotidyl transferase domain-containing protein
DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER
Has ATPase and non-specific DNA-binding activities.
Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
DNA mismatch repair proteins mutS family
3-hydroxy-3-methylglutaryl-CoA reductase
Transcription regulator PadR N-terminal domain-containing protein
FORMATE LYASE ACTIVATING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15630)-RELATED
CHROMOSOME TRANSMISSION FIDELITY FACTOR 18
Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.
Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
Belongs to the activator 1 small subunits family. RfcL subfamily.
BULB-TYPE LECTIN DOMAIN-CONTAINING PROTEIN
ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED
CobQ/CobB/MinD/ParA nucleotide binding domain-containing protein
Histidine kinase CheA-like, homodimeric domain
Histidine kinase CheA-like, P2 response regulator-binding domain
Sigma3 and sigma4 domains of RNA polymerase sigma factors
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
B12-binding domain-containing radical SAM protein
POTASSIUM CHANNEL PROTEIN 2-RELATED-RELATED
RCK N-TERMINAL DOMAIN-CONTAINING PROTEIN
Ferrous iron transport protein B C-terminal
Methylene-tetrahydrofolate reductase C-terminal domain-containing protein
Methylene-tetrahydrofolate reductase C-terminal
TRANSCRIPTION INITIATION FACTOR IIB-RELATED
Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
Adenylosuccinate Synthetase, subunit A, domain 1
Adenylosuccinate Synthetase, subunit A, domain 2
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.
Belongs to the adenylosuccinate synthetase family.
LIPOPROTEIN-RELEASING SYSTEM ATP-BINDING PROTEIN LOLD
Obg-like GTPase YGR210-like G4 motif-containing
DNA-3-methyladenine glycosylase AlkA, N-terminal domain
Iron dependent repressor metal binding and dimerisation
OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN
TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED
Chemotaxis response regulator protein-glutamate methylesterase
DNA gyrase/topoisomerase IV, subunit A, C-terminal
DNA GYRASE SUBUNIT A, CHLOROPLASTIC/MITOCHONDRIAL
Belongs to the type II topoisomerase GyrA/ParC subunit family.
C-terminal effector domain of the bipartite response regulators
Pyruvate carboxyltransferase domain-containing protein
BIOTIN SYNTHASE-RELATED PROTEIN, RADICAL SAM SUPERFAMILY
NADH:ubiquinone oxidoreductase-like 20kDa subunit domain-containing protein
TYPE III RESTRICTION-MODIFICATION SYSTEM HINDVIP ENZYME MOD-RELATED
L-asparaginase N-terminal domain-containing protein
ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
Aspartate aminotransferase family protein
BIFUNCTIONAL NADP PHOSPHATASE/NAD KINASE
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
TRK SYSTEM POTASSIUM UPTAKE PROTEIN TRKA
Adenylosuccinate Synthetase, subunit A, domain 3
Pyruvate formate lyase-activating protein
ARCHAEAL-TYPE GLUTAMATE SYNTHASE [NADPH]
Belongs to the glutamate synthase family.
RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
HYDROGENASE EXPRESSION/FORMATION PROTEIN HUPK
Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
Uncharacterised protein PF08960, DUF1874
H4MPT-linked C1 transfer pathway protein
Transcription initiation factor IIB family protein
Belongs to the V-ATPase F subunit family.
ABC transporter involved in vitamin B12 uptake, BtuC
Belongs to the ABC-3 integral membrane protein family.
Formylmethanofuran dehydrogenase subunit C
DNA replication factor RFC1 C-terminal domain-containing protein
Peptidase C1A papain C-terminal domain-containing protein
TRNA-SPECIFIC ADENOSINE DEAMINASE-RELATED
OLIGO/DIPEPTIDE TRANSPORT, PERMEASE PROTEIN (DPPC-2)
2,3-DIKETO-L-GULONATE TRAP TRANSPORTER SMALL PERMEASE PROTEIN YIAM
Dihydroorotate dehydrogenase, electron transfer subunit
Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module
DIHYDROOROTATE DEHYDROGENASE B (NAD(+)), ELECTRON TRANSFER SUBUNIT
DIHYDROOROTATE DEHYDROGENASE B (NAD(+)), ELECTRON TRANSFER SUBUNIT-RELATED
Ferredoxin reductase-like, C-terminal NADP-linked domain
Dihydroorotate dehydrogenase electron transfer subunit
Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2
NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED
Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
Belongs to the Mrp/NBP35 ATP-binding proteins family.
6-phosphogluconate dehydrogenase C-terminal like domain
Ferrodoxin-fold anticodon-binding domain
Electron transport complex subunit B, putative Fe-S cluster
CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL
CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL-RELATED
RecF/RecN/SMC N-terminal domain-containing protein
ABC transporter type 1, transmembrane domain
ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL
GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE 2
Type I glyceraldehyde-3-phosphate dehydrogenase
Glyceraldehyde 3-phosphate dehydrogenase catalytic
PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED
3-HYDROXY-5-PHOSPHONOOXYPENTANE-2,4-DIONE THIOLASE-RELATED
Fructose-1,6-Bisphosphatase, subunit A, domain 1
DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE
ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL
Isocitrate/isopropylmalate dehydrogenase family protein
Sulfite reductase, dissimilatory-type subunit alpha
Phosphoribosylglycinamide synthetase C-domain domain-containing protein
Phosphoribosylglycinamide synthetase C-domain
RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG
Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
Belongs to the TDD superfamily. TSR3 family.
RNase L inhibitor RLI-like possible metal-binding
16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal
Exosome-associated factor Rrp6 N-terminal domain-containing protein
Exosome-associated factor Rrp6 N-terminal
PROTEIN COFACTOR ASSEMBLY OF COMPLEX C SUBUNIT B CCB3, CHLOROPLASTIC-RELATED
Macrolide ABC transporter ATP-binding protein
COMPONENT OF ATP-DEPENDENT DSDNA EXONUCLEASE
Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase
Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
Belongs to the methyltransferase superfamily. Fibrillarin family.
4-DEOXY-4-FORMAMIDO-L-ARABINOSE-PHOSPHOUNDECAPRENOL DEFORMYLASE ARND-RELATED
Polysaccharide biosynthesis protein C-terminal
Mga helix-turn-helix domain-containing protein
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
LOR/SDH bifunctional enzyme, conserved domain
RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE B-RELATED
RsmB/NOP family class I SAM-dependent RNA methyltransferase
Peptidase S54 rhomboid domain-containing protein
CO dehydrogenase flavoprotein, C-terminal domain
Type II secretion system protein GspG C-terminal domain-containing protein
Type II secretion system protein GspG C-terminal
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit CofH
Nitrite/Sulfite reductase ferredoxin-like
(5-formylfuran-3-yl)methyl phosphate synthase
4-(hydroxymethyl)-2-furancarboxaldehyde-phosphate synthase
Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).
REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT
Belongs to the activator 1 small subunits family. RfcS subfamily.
Polymerase/histidinol phosphatase N-terminal
archaeoglobus fulgidus dsm 4304 superfamily
DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG
NIF system FeS cluster assembly NifU N-terminal
FEMO COFACTOR BIOSYNTHESIS PROTEIN NIFB-RELATED
FAD-binding/transporter-associated domain-like
Carbamoyl phosphate synthase small subunit
ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN
D-ribose-5-phosphate isomerase (RpiA), lid domain
glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating)
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.
Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD
GLYCYL-RADICAL ENZYME ACTIVATING ENZYME MJ0021-RELATED
Regulator of K+ conductance, C-terminal domain
DNA-directed RNA polymerase, insert domain
DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
Insert subdomain of RNA polymerase alpha subunit
DNA-directed RNA polymerase subunit Rpo3
Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
Sulfopyruvate decarboxylase subunit beta
2-HYDROXYGLUTARYL-COA DEHYDRATASE, D-COMPONENT-RELATED
Benzoyl-CoA reductase, bzd-type, subunit O
Belongs to the FldB/FldC dehydratase alpha/beta subunit family.
Methanogenesis regulatory protein FilR1 middle
MEMBRANE TRANSPORTER PROTEIN YDHB-RELATED
INTEGRAL MEMBRANE EFFLUX PROTEIN-RELATED
Nicotinate phosphoribosyltransferase C-terminal
Threonylcarbamoyladenosine tRNA methylthiotransferase
MIND SUPERFAMILY P-LOOP ATPASE CONTAINING AN INSERTED FERREDOXIN DOMAIN
BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE [ASYMMETRICAL]
DIADENOSINE 5,5-P1,P4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE MUTT
PHOTOSYSTEM II STABILITY/ASSEMBLY FACTOR HCF136, CHLOROPLASTIC
Oligoxyloglucan reducing end-specific cellobiohydrolase
Photosynthesis system II assembly factor Ycf48/Hcf136-like
LamG-like jellyroll fold domain-containing protein
RESISTANCE PROTEIN MDTM, PUTATIVE-RELATED-RELATED
ATP-DEPENDENT ZINC METALLOPROTEASE FTSH 4, MITOCHONDRIAL
THIF-type NAD/FAD binding fold domain-containing protein
GENERAL SECRETION PATHWAY PROTEIN A-RELATED
Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.
Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
Molybdopterin dinucleotide-binding domain-containing protein
Leucine-binding protein domain-containing protein
TYPE I RESTRICTION ENZYME ECOKI R PROTEIN
Helicase/UvrB N-terminal domain-containing protein
Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase
Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
Belongs to the CDP-archaeol synthase family.
Nascent polypeptide-associated complex subunit alpha-like UBA
NITROGEN ASSIMILATION TRANSCRIPTIONAL ACTIVATOR-RELATED
OB-fold nucleic acid binding domain-containing protein
Respiratory nitrate reductase 1 gamma chain
PROTEIN ADENYLYLTRANSFERASE MNTA-RELATED
TRNA (CYTIDINE(56)-2'-O)-METHYLTRANSFERASE
tRNA ribose 2'-O-methyltransferase aTrm56
Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.
LEU/ILE/VAL-BINDING ABC TRANSPORTER SUBUNIT
Belongs to the leucine-binding protein family.
UPF0051 PROTEIN ABCI8, CHLOROPLASTIC-RELATED
SufD family Fe-S cluster assembly protein
DNA-directed RNA polymerase RpoA/D/Rpb3-type
MEMBRANE-ASSOCIATED ZINC METALLOPROTEASE M50B
Formylmethanofuran dehydrogenase subunit E domain-containing protein
MOLYBDOPTERIN SYNTHASE CATALYTIC SUBUNIT
Molybdenum cofactor biosynthesis protein MoaE
CHROMOSOME-PARTITIONING PROTEIN PARB-RELATED
ParB/Sulfiredoxin domain-containing protein
3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE
SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER
6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
6-hydroxymethyl-7,8-dihydropterin diphosphokinase
7,8-dihydro-6-hydroxymethylpterin diphosphokinase
7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase
Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).
6-hydroxymethylpterin diphosphokinase MptE-like
Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
CBS DOMAIN-CONTAINING PROTEIN CBSX1, CHLOROPLASTIC
TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3
TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED
phosphoribosylformylglycinamidine cyclo-ligase
Sodium/calcium exchanger membrane region
Zn-dependent metallo-hydrolase RNA specificity
Coenzyme F420 hydrogenase/dehydrogenase beta subunit N-terminal domain-containing protein
Coenzyme F420 hydrogenase/dehydrogenase beta subunit N-terminal
MacB-like periplasmic core domain-containing protein
2-ISOPROPYLMALATE SYNTHASE 1, CHLOROPLASTIC-RELATED