Alan Ruttenberg Andrew Spear Pierre Grenon Chris Mungall Cristian Cocos Holger Stenzhorn Mathias Brochhausen Sarah Lerch Stefan Schulz Ulf Schwarz 2007-11-29 application/rdf+xml http://www.ifomis.org/bfo/1.1 en Insitute for Formal Ontology and Medical Information Science (IFOMIS) Institute for Formal Ontology and Medical Information Science (IFOMIS) http://creativecommons.org/licenses/by/3.0 Barry Smith and Pierre Grenon: "The Cornucopia of Formal Ontological Relations" Barry Smith, Werner Ceusters, Bert Klagges, Jacob Koehler, Anand Kumar, Jane Lomax, Chris Mungall, Fabian Neuhaus, Alan Rector and Cornelius Rosse: "Relations in Biomedical Ontologies" Barry Smith: "Against Fantology" Barry Smith: "Basic Tools of Formal Ontology" Barry Smith: "Beyond Concepts: Ontology as Reality Representation" Pierre Grenon and Barry Smith: "SNAP and SPAN: Towards Geospatial Dynamics" Pierre Grenon, Barry Smith and Louis Goldberg: "Biodynamic Ontology: Applying BFO in the Biomedical Domain" Pierre Grenon: "BFO in a Nutshell: A Bi-categorial Axiomatization of BFO and Comparison with DOLCE" Pierre Grenon: "Nuts in BFO's Nutshell: Revisions to the Bi-categorial Axiomatization of BFO" Pierre Grenon: "Spatio-temporality in Basic Formal Ontology: SNAP and SPAN, Upper-Level Ontology, and Framework for Formalization" ACGT Master Ontology Basic Formal Ontology (BFO) Relationship Ontology (RO) 1.0 1.1.1 Ideally, the range should be confined to chemical processes def = "On the other side. The contralateral breast is the breast on the other breast. A stroke affecting the right side of the brain may cause contralateral paralysis, affecting the left arm and leg. The opposite of contralateral is ipsilateral which refers to the same side." Not sure what the domain might be though... see http://en.wikipedia.org/wiki/Medical_grafting def = "On the same side. A study of "ipsilateral breast tumor recurrence following lumpectomy and radiation therapy" pertains to cancer returning in the same breast as has been treated. A lesion in the right side of the brain may affect vision ipsilaterally, in the right eye." Not sure what the domain migh be though... There's another RO relation called "locationOf," which is why I have renamed this to locusOf. synonyms: assessment, evaluation old name: makesUseOfMedicalProcedure The corect way to deal with "reveals" is to make it a 3 place relation: x reveals quality of y. Existence is a property, so we shouldn't feel compelled to add "process" to the range. a part is a subsystem in case it has some contribution to the function of the greater system (i.e. is not causally inert) the key difference b/w participatesIn and undergoes is that the continuant that undergoes a process is the largest continuant that undergoes that process old name: undergoesMedicalProcedure old name: usedInMedicalProcedure Relation of proximity between disjoint continuants. Adjacent_to satisfies some of the axioms governing the relation referred to in the literature of qualitative topology as 'external connectedness' . Analogs of other mereotopological relations (qualitative relations between spatial regions involving parthood, boundary and connectedness) can also be defined, and these too can be applied to the material and immaterial continuants which occupy such regions on the instance level. adjacent_to agent_in Containment obtains in each case between material and immaterial continuants, for instance: lung containedIn thoracic cavity; bladder containedIn pelvic cavity. Hence containment is not a transitive relation. If c partOf c1 at t then we have also, by our definition and by the axioms of mereology applied to spatial regions, c locatedIn c1 at t. Thus, many examples of instance-level location relations for continuants are in fact cases of instance-level parthood. For material continuants location and parthood coincide. Containment is location not involving parthood, and arises only where some immaterial continuant is involved. To understand this relation, we first define overlap for continuants as follows: c1 overlap c2 at t =def for some c, c partOf c1 at t and c partOf c2 at t. contained_in contains derived_into Derivation is a relation holding between non-identicals. More precisely, it holds between distinct material continuants when one succeeds the other across a temporal divide in such a way that at least a biologically significant portion of the matter of the earlier continuant is inherited by the later. Thus we will have axioms to the effect that from c derivesFrom c1 we can infer that c and c1 are not identical and that there is some instant of time t such that c1 exists only prior to and c only subsequent to t. We will also be able to infer that the spatial region occupied by c as it begins to exist at t overlaps with the spatial region occupied by c1 as it ceases to exist in the same instant. derives_from has_improper_part has_integral_part As for partOf, with the additional constraint that subject and object may be identical improper_part_of C integralPartOf C' if and only if: C partOf C' AND C' hasPart C integral_part_of location_of Relation between two classes, in which instances retain their identity yet change their classification by virtue of some kind of transformation. Formally: C transformationOf C' if and only if given any c and any t, if c instantiates C at time t, then for some t', c instantiates C' at t' and t' earlier t, and there is no t2 such that c instantiates C at t2 and c instantiates C' at t2. When an embryonic oenocyte (a type of insect cell) is transformed into a larval oenocyte, one and the same continuant entity preserves its identity while instantiating distinct classes at distinct times. The class-level relation transformationOf obtains between continuant classes C and C1 wherever each instance of the class C is such as to have existed at some earlier time as an instance of the distinct class C1 (see Figure 2 in paper). This relation is illustrated first of all at the molecular level of granularity by the relation between mature RNA and the pre-RNA from which it is processed, or between (UV-induced) thymine-dimer and thymine dinucleotide. At coarser levels of granularity it is illustrated by the transformations involved in the creation of red blood cells, for example, from reticulocyte to erythrocyte, and by processes of development, for example, from larva to pupa, or from (post-gastrular) embryo to fetus or from child to adult. It is also manifest in pathological transformations, for example, of normal colon into carcinomatous colon. In each such case, one and the same continuant entity instantiates distinct classes at different times in virtue of phenotypic changes. transformation_of transformed_into acgt:ABVDChemo ABVD is named after the initials of the chemotherapy drugs used, which are: doxorubicin (pronounced docks-o-rou-bi-sin, originally called Adriamycin®) bleomycin (blee o my sin), vinblastine (vin blas teen) and dacarbazine (de car b zeen). acgt:ACChemo AC is named after the initials of the drugs used and involves the chemotherapy drugs doxorubicin (pronounced docks-o-rou-bi-sin, originally known as Adriamycin®) and cyclophosphamide (sigh clo fos fa mide). acgt:AJCDifferentiation recommended by the American Joint Commission on Cancer acgt:ALPLevel aka AlkalinePhosphatase Level acgt:ALTCount Alanine transaminase (ALT) Count acgt:ANC CountingAbsoluteNeutrophils acgt:ANCount Absolute neutrophil count (ANC) acgt:AR aka Androgen receptor; the androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor which is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone. acgt:ASTCount Aspartate transaminase (AST) Count acgt:Abdomen acgt:AbducensNerve acgt:Abnormal acgt:Abscess acgt:AbsoluteCertainty acgt:AbsoluteNeutrophilCount Abbr.: ANC acgt:AbsorbedRadiationDose acgt:Accidental acgt:AcellularAnatomicalStructure acgt:Actinomycin-D Synonym: Dactinomycine acgt:Address 1 acgt:AddressPart acgt:Adenoma acgt:Adenomastectomy acgt:Adhesion acgt:AdhesionIleus acgt:AdiposeTissue acgt:AdjuvantChemotherapy acgt:AdjuvantTherapy = treatment given after the primary treatment to increase the chances of a cure. Adjuvant therapy may include chemotherapy, radiation therapy or hormone therapy acgt:AdministrativeProcess acgt:AdministrativeRole acgt:AdrenalGland acgt:Adriamycin =Doxorubicin 1 acgt:Age acgt:AlanineAminotransferase acgt:Alcoholism acgt:AlcoholismProcess acgt:AlimentarySystemSymptom acgt:AlkalinePhosphataseTest 0 acgt:Allergy 0 acgt:Alopecia acgt:AmbiguousGender acgt:Amputation acgt:AnalgeticDrug acgt:Anaplasia acgt:AnatomicalCluster acgt:AnatomicalCompartment acgt:AnatomicalJunction acgt:AnatomicalSet 0 acgt:AnatomicalStructure 0 acgt:Anemia acgt:AnemiaGrade acgt:AnemiaGrade0 acgt:AnemiaGrade1 acgt:AnemiaGrade2 acgt:AnemiaGrade3 acgt:AnemiaGrade4 acgt:Aniridia acgt:AniridiaProcess acgt:Ankle acgt:AnteriorCranialFossa acgt:AnteriorInferiorRenalSegment acgt:AnteriorSuperiorRenalSegment acgt:Anthracycline Anthracyclines are a class of chemotherapeutic agents based upon daunosamine and tetra-hydro-naphthacene-dione. true acgt:AntiTumorAntibiotic acgt:AntiarrhythmicPharmacotherapy acgt:AntibioticDrug acgt:AntibodyMicroarray acgt:AntimycoticDrug acgt:Arimidex acgt:Arm acgt:Aromatase acgt:AromataseInhibitor 0 acgt:Arrhythmia acgt:ArrhythmiaGrade acgt:ArrhythmiaGrade0 definition: No toxicity acgt:ArrhythmiaGrade1 definition: Asymptomatic, no treatment acgt:ArrhythmiaGrade2 definition: symptomatic, no treatment acgt:ArrhythmiaGrade3 definition: Requiring treatment acgt:ArrhythmiaGrade4 definition: Hypotension, life-threatening 0 acgt:Arthralgia acgt:AspartateAminotransferase 0 acgt:Asthenia 0 0 0 acgt:Ataxia acgt:Atlas acgt:Audiometry acgt:Autopsy acgt:Avital acgt:Axilla acgt:AxillaryNodeDissection acgt:Axis acgt:BEPChemo BEP is named after the initials of the chemotherapy drugs used, which are: bleomycin (pronounced blee-o-my-sin), etoposide (e-top-o-side) and cisplatin (sis-pla-tin), which contains platinum. acgt:BacterialInfection acgt:BacterialInfectionProcess acgt:BathIrradiation acgt:BedriddenState 0 acgt:BenignNeoplasm acgt:Betablocker Syn.: Beta Receptor-Blocker acgt:BiZygotic acgt:Bilateral acgt:BilateralOvariectomy acgt:Bilirubin acgt:BilirubinGrade acgt:BilirubinGrade0 acgt:BilirubinGrade1 acgt:BilirubinGrade2 acgt:BilirubinGrade3 acgt:BilirubinGrade4 acgt:BinaryStatus 0 acgt:BioBankingOrganization acgt:BiogenicAmine 0 acgt:BiologicalIndependentContinuant acgt:BiologicalMacromolecule acgt:BiologicalMarker acgt:Biologist acgt:Biopsy 0 0 acgt:BiopsyNeedle acgt:BiopsyWithIncision 0 acgt:BiopsyWithoutIncision acgt:Birth acgt:BirthCityName acgt:BirthCountryName acgt:Bleeding acgt:Blood acgt:BloodPlasmaSample aka serum sample 1 acgt:BloodPressure acgt:BloodPressureMeasuringProcess acgt:BloodPressureRecordingProcess 0 acgt:BloodSample 0 acgt:BloodSerumSample acgt:BloomRichardsonDifferentiation used for breast cancer; Wikipedia: The Bloom-Richardson grade (BR grade) is a a histologic grade assigned by pathologists to breast cancers. It is the most common type of cancer grade system currently used. It is a semi-quantitative grading method based on three morphologic features of invasive breast cancers. The morphologic features that are used are: degree of tumor tubule formation (percentage of cancer composed of tubular structures) tumor mitotic activity (rate of cell division) nuclear pleomorphism of tumor cells (nuclear grade, change in cell size and uniformity) Each of these features is assigned a score ranging from 1 to 3. The scores are then added together for a final sum that will range between 3 to 9. This value is then used to grade the tumor as follows : 3-5 Grade 1 tumor (well-differentiated). 6-7 Grade 2 tumor (moderately-differentiated). 8-9 Grade 3 tumor (poorly-differentiated). acgt:Body acgt:BodyCompartmentSubdivision 1 acgt:BodyMassIndex acgt:BodyOfInvertebrate acgt:BodyOfVertebrate acgt:BodyProper acgt:BodySubstance acgt:BodySurfaceArea aka BSA: In physiology and medicine, the body surface area (BSA) is the measured or calculated surface of a human body. For many clinical purposes BSA is a better indicator of metabolic mass than body weight because it is less affected by abnormal adipose mass. Estimation of BSA is simpler than many measures of volume. acgt:BoneMarrow acgt:BoneMarrowProgenitorCellSample acgt:BoneOrgan acgt:BoneScintigraphy acgt:BoostIrradiation acgt:Brachytherapy acgt:Brain acgt:Brainstem acgt:Breadth ? acgt:Breast acgt:BreastCancerTumorMarker acgt:BreastResection acgt:BuddChiariSyndrome acgt:BuddChiariSyndromeProcess acgt:Bulging acgt:Buttock acgt:C-VAMPChemo C-VAMP is named after the initials of the chemotherapy drugs used in the treatment, which are cyclophosphamide (pronounced sigh-clo-fos-fa-mide), vincristine (vin-chris-teen), doxorubicin (docks-o-rou-bi-sin, originally called Adriamycin®) and methyl-prednisolone (me-thile pred-ni-so-lone), which is a steroid. acgt:CAFChemo CAF is named after the initials of the drugs involved. These are: cyclophosphamide (pronounced sigh-clo-fos-fa-mide), doxorubicin (docks-o-roo-bi-sin, originally called Adriamycin®) and fluorouracil (floo-ro-you-ro-sill, also known as 5FU). acgt:CAVChemo CAV is named after the initials of the chemotherapy drugs used, which are: cyclophosphamide (pronounced sigh-clo-fos-fa-mide), doxorubicin (docks-o-rou-bi-sin), which was originally called Adriamycin® and vincristine (vin-chris-teen). acgt:CD34SelectionPurging Def.: A purging process selecting the componenets of a sample by using antigen CD34 as indicator. The result is a sample of only stem cells. acgt:CHOPChemo R-CHOP is named after the chemotherapy drugs used in the treatment. It involves the monoclonal antibody rituximab (pronounced ri-tucks-i-mab), and the drugs: cyclophosphamide (sigh-clo-fos-fa-mide), doxorubicin (docks-o-rou-bi-sin, originally called Adriamycin®), vincristine (vin-chris-teen, originally known as Oncovin®) and prednisolone (pred-ni-so-lone), which is a steroid. acgt:CMFChemo CMF is named after the initials of the chemotherapy drugs involved, which are cyclophosphamide (pronounced sigh-clo-fos-fa-mide), methotrexate (me-tho-trex-ate) and fluorouracil (floo-ro-you-ro-sill, which is also known as 5FU). 0 acgt:CRF acgt:CRFNumber acgt:CWSChemotherapyRegime Chemotherapy regime according to the "Cooperative Weichteilsarkom Studie" acgt:CancerTreatment acgt:CanonicalAnatomicalCavity acgt:CanonicalFieldOfVision 0 acgt:CanonicalMaterialOrganismalIndependentContinuant ALL FMA classes under "FMA: MaterialAnatomicalEntity" are subsumed here. acgt:CanonicalOrganismalSpace acgt:CanonicalOrganismalSurface acgt:CanonicalVisualAcuity acgt:CapecitabineDocetaxelChemo The treatment involves the two chemotherapy drugs: capecitabine (pronounced cap-sight-a-been) and docetaxel (doe-se-tax-el), which is commonly called Taxotere® (tax-oh-tare). acgt:Carboplatin acgt:CarboplatinEtoposideChemo The treatment involves two chemotherapy drugs: carboplatin (pronounced car-bo-pla-tin) and etoposide (e-top-o-side), which is also known as Etopophos® or Vepesid®. acgt:Carcinoma 0 acgt:CardiacArrest acgt:CardiacCycle 0 acgt:CardiacMurmur acgt:CardiacQuestionnaire acgt:CardiacSymptom acgt:CardinalBodyPart acgt:CardinalCellPart acgt:CardinalFreeLimbSegment acgt:CardinalOrganPart acgt:CardinalTissuePart acgt:CardioPerformanceClassI patients with no limitation of activities; they suffer no symptoms from ordinary activities. acgt:CardioPerformanceClassII patients with slight, mild limitation of activity; they are comfortable with rest or with mild exertion. acgt:CardioPerformanceClassIII patients with marked limitation of activity; they are comfortable only at rest. acgt:CardioPerformanceClassIV patients who should be at complete rest, confined to bed or chair; any physical activity brings on discomfort and symptoms occur at rest. acgt:CardioPerformanceRating acgt:CardioToxicity acgt:CardiopulmonaryBypass acgt:CardiovascularSystemSymptom acgt:CareProcess 0 0 acgt:CatecholaminLevel 0 acgt:Catecholamine acgt:CavitatedOrgan acgt:Cell acgt:CellComponent acgt:CellCounting acgt:CellPartCluster acgt:CellPartClusterOfNeuraxis acgt:CentralNeurotoxicity acgt:CentralNeurotoxicityGrade acgt:CentralNeurotoxicityGrade0 acgt:CentralNeurotoxicityGrade1 acgt:CentralNeurotoxicityGrade2 acgt:CentralNeurotoxicityGrade3 acgt:CentralNeurotoxicityGrade4 acgt:Cerebellum acgt:CerebralHemisphere acgt:CerebralHemorrhage acgt:CerebralSeizure 0 acgt:CerebrospinalLiquidPuncture 0 0 0 acgt:CerebrospinalLiquidSample acgt:CertaintyLevel acgt:CervicalVertebra acgt:CharacterChange 0 0 0 1 acgt:ChemicalSubstance acgt:ChemoPlusHGFStemCellMobilisation acgt:ChemoStemCellMobilisation 0 0 0 0 acgt:Chemotherapy acgt:ChemotherapyCycle 1 acgt:ChemotherapyDrug acgt:ChemotherapyRegime acgt:ChestWall acgt:ChildhoodRegularCheckup acgt:ChlVPPChemo ChlVPP is named after the initials of the chemotherapy drugs used, which are chlorambucil (pronounced claw-ram-bu-cil), vinblastine (vin-blas-teen), procarbazine (pro-car-ba-zeen) and prednisolone (pred-ni-so-lone), which is a steroid. acgt:ChromophobeRenalCarcinoma 0 acgt:Chromosome 1 1 acgt:ChromosomeAberration acgt:ChronicViralInfection acgt:ChronicViralInfectionProcess acgt:Circumference acgt:CisplatinFluorouracilChemo This treatment involves two chemotherapy drugs: cisplatin (pronounced sis-pla-tin) and fluorouracil (floo-ro-you-ro-sill); which is also known as 5FU. acgt:CityName acgt:ClearCellCarcinoma acgt:ClearCellTumor acgt:ClinicalClassTNM Clinical classification (Pretreatment clinical classification), designated TNM (or cTNM). This is based on evidence acquired before treatment. Such evidence arises from physical examination, imaging, endoscopy, biopsy, surgical exploration and other relevant examinations. acgt:ClinicalDocumentation acgt:ClinicalExamination aka Physical Examination 1 0 acgt:ClinicalResearch 0 0 acgt:ClinicalStudy acgt:ClinicalStudyIdentifier Name or other identifier of a clinical study in which the patient might be enrolled. acgt:ClinicalStudyPatientNumber ??????? acgt:ClinicalStudyProtocol acgt:ClinicalTrial acgt:ClinicalTrialIdentifier acgt:ClinicalTrialPatientNumber acgt:ClinicalTrialProtocol acgt:CoagulationDisorder acgt:Coagulopathy aka "coagulation disorder" acgt:CoagulopathyProcess 0 acgt:Cobalt-60 Def.: Cobalt-60 is a chemical substance (a metal) that is radioactive and used in radiotherapy. acgt:CoccygealVertebra acgt:ColloidCarcinoma aka MucinousCarcinoma acgt:Colon acgt:ColonyStimulatingFactor acgt:Coma acgt:ComedoCarcinoma acgt:Comment 1 acgt:CommonToxicityCriteriaGrade Common Toxicity Criteria (CTC) is a standardised classification of side effects used in assessing drugs for cancer therapy. Most US drug trials base their observations on this system which has a range of grades from 0-5, 5 usually equating to death. Currently version 3.0 is in use, released in 2003. acgt:Company acgt:CompartmentOfTrunk acgt:Complete acgt:CompleteParaplegia acgt:CompleteTumorRemission acgt:CompletelyNecroticNephroblastoma 0 acgt:CompletenessLevel 0 0 acgt:Complication acgt:ComputerScientist 0 acgt:Computertomography acgt:ConeBiopsy acgt:ConsentForm 0 acgt:Consenting acgt:ConsiderablyReducedActivityState acgt:ContrastMedium acgt:ConvulsiveSeizure acgt:CoreNeedleBiopsy acgt:CorticomedullaryOrgan acgt:Coughing acgt:CountingPlatelets acgt:CountingRedBloodCells acgt:CountryName 0 acgt:CranialNerve acgt:CranialNerveNumber acgt:CreatineKinase acgt:CreatineKinaseBB acgt:CreatineKinaseMB acgt:CreatineKinaseMM acgt:Creatinine acgt:CreatinineClearance acgt:CreatinineClearanceGrade acgt:CreatinineClearanceGrade0 acgt:CreatinineClearanceGrade1 acgt:CreatinineClearanceGrade2 acgt:CreatinineClearanceGrade3 acgt:CreatinineClearanceGrade4 acgt:CreatinineGrade acgt:CreatinineGrade0 acgt:CreatinineGrade1 acgt:CreatinineGrade2 acgt:CreatinineGrade3 acgt:CreatinineGrade4 acgt:Criterion aka requirement; states of affairs play roles of criteria; how does one build a state of affairs in BFO?; probably reducible to quality and hasMeasurement--after all a state is the fact that some parameter has some value.... Food for further thought; for now it stays like this. acgt:CumulativeDose acgt:Cycle acgt:Cyclophosfamide acgt:CysticNephroma acgt:CysticPartiallyDifferentiatedNephroblastoma acgt:CysticTumor acgt:CytogeneticExamination acgt:Cytokine acgt:CytologicalExamination acgt:Cytostatic acgt:DCIS Ductal Carcinoma In Situ, aka intraductal carcinoma acgt:DCISHistologicalAssessment acgt:DHAPandARDHAPChemo DHAP is named after the drugs that are used in the treatment. This includes dexamethasone (pronounced decks-a-meth-a-sone), which is a steroid, and the chemotherapy drugs cytarabine (sigh-tare-a-been), which is sometimes called Ara C, and cisplatin (sis-pla-tin), which contains platinum. R-DHAP also includes the monoclonal antibody drug rituximab (Mabthera®). acgt:DNA acgt:DNAMicroarray acgt:DNAReplication acgt:Damaged acgt:DataProcessingConsent acgt:DataProcessingPatientConsentForm acgt:DataReleasing acgt:DataReleasingToGCCR acgt:Daunorubicin 1 acgt:Day acgt:DeGramontChemo The 'de Gramont' regimen is named after the doctor who first used it and involves the drugs fluorouracil (pronounced floo-ro-you-ro-sill), also known as 5FU and folinic acid, which is also known as leucovorin (loo-co-vor-rin). This is a drug that makes 5FU more effective. The de Gramont regimen is one of several different ways of combining these two drugs and each has a different name. Some doctors in the UK use a version of the de Gramont regime known as modified de Gramont, because they feel it is easier to give and just as effective. acgt:Death acgt:DecisionForTherapyEnd acgt:DeclarativeProposition acgt:DeepFascialSystemSymptom 0 acgt:Deglutition acgt:Density acgt:Depth ? acgt:Dermatologist acgt:Design acgt:Desquamtation 0 acgt:Diagnosis acgt:DiagnosisConfirmation acgt:DiagnosticProcess o ld name: DiagnosticProcedure acgt:Diameter acgt:Diaphragm acgt:DiaphragmaticHernia acgt:Diarrhea acgt:DiarrheaGrade acgt:DiarrheaGrade0 acgt:DiarrheaGrade1 acgt:DiarrheaGrade2 acgt:DiarrheaGrade3 acgt:DiarrheaGrade4 acgt:DiastolicBloodPressure acgt:DifferentiatedHemalCell acgt:DifferentiationClass aka as Tumor Grade acgt:DiffuseAnaplasia acgt:DiffuseAnaplasticNephroblastoma acgt:DigitalFile acgt:DigitalisGlycoside acgt:Director 1 1 acgt:Disease acgt:DiseaseProcess acgt:DispatchingOfBiomedicalItem acgt:DispatchingOfHistoSample 1 1 acgt:DispatchingOfMedicalImage acgt:DistalFreeLimbSegment acgt:Diuretic acgt:Docetaxel acgt:DocetaxelCisplatinChemo The treatment involves two chemotherapy drugs, docetaxel (pronounced doe-se-tax-el), which is commonly known as Taxotere® (tax-oh-tare), and cisplatin (sis-pla-tin). acgt:DocetaxelCycle 0 0 acgt:Document 1 acgt:Dose acgt:DoseIncrease 0 acgt:DoseModulation acgt:DoseReduction acgt:Doxorubicin acgt:DoxorubicinIfosfamideChemo The treatment involves two chemotherapy drugs, doxorubicin (pronounced docks-o-rou-bi-sin) and ifosfamide (i-fos-fa-mide). You may sometimes hear this treatment being called AI after the drugs that are used (doxorubicin was originally called Adriamycin®). Other names for this treatment are Dox-Ifos and I-Ad. acgt:Drainage acgt:Drash acgt:DrashProcess acgt:Drug acgt:DysontogeneticTumor acgt:Dyspnea acgt:E-CMFChemo E-CMF, which is also known as Epi-CMF, is named after the initials of the four chemotherapy drugs involved: epirubicin (pronounced epi-roo-biss-sin), cyclophosphamide (sigh-clo-fos-fa-mide), methotrexate (me-tho-trex-ate) and fluorouracil (floo-ro-you-ro-sill), which is also known as 5FU. acgt:ECChemo EC is named after the initials of the chemotherapy drugs used in the treatment, epirubicin (pronounced epi-roo-biss-sin) and cyclophosphamide (sigh-clo-fos-fa-mide). acgt:ECFChemo ECF is named after the initials of the chemotherapy drugs used, which are epirubicin (pronounced epi-roo-biss‑sin), cisplatin (sis-pla-tin) and fluorouracil (floo-ro-you-ro-sill), which is also known as 5FU. acgt:ECG German: EKG acgt:ECOG0 acgt:ECOG1 acgt:ECOG2 acgt:ECOG3 acgt:ECOG4 acgt:ECOG5 acgt:ECOGPerformanceRating aka the WHO or the Zubrod score acgt:ECXChemo ECX is named after the initials of the chemotherapy drugs used, which are epirubicin (pronounced epi-roo-biss-sin), cisplatin (sis-pla-tin) and capecitabine (kap-sight-a-been), which is also known as Xeloda® (ze-load-a). acgt:EEXChemo EEX is named after the initials of the drugs used, which are epirubicin (pronounced epi-roo-biss-sin), oxaliplatin (ox-ally-plat-in), which is also known as Eloxatin® (e-locks-a-tin) and capecitabine (kap-sight-a-been), also known as Xeloda® (ze-load-a). acgt:ELFChemo ELF is named after the initials of the chemotherapy drugs used, which are etoposide (pronounced e-top-o-side), leucovorin (loo-co-vor-rin), which is also known as folinic acid, and fluorouracil (floo-ro-you-ro-cil), also known as 5FU. acgt:ELISA aka Enzyme-linked immunosorbent assay acgt:EMailAddress acgt:EPOLevelTest acgt:ER An estrogen receptor (ER) is a nuclear receptor for estrogens such as estradiol (the main endogenous human estrogen). Estrogen receptors are intracellular proteins like other steroid hormone receptors. acgt:ERHistologicalAssessment acgt:ERNegative acgt:ERPositive acgt:ERStatus acgt:ERT Estrogen Replacement Therapy acgt:ESHAPandR-ESHAPChemo ESHAP is named after the chemotherapy drugs used in the treatment, which are etoposide (pronounced e-top-o-side), methylprednisolone (me-thile-pred-ni-so-lone), which is a steroid, cytarabine (sigh-tare-a-been), which is sometimes known as Ara C and cisplatin (sis-pla-tin), which contains platinum. R-ESHAP also includes the drug rituximab (Mabthera®). Rituximab is a monoclonal antibody which is is used to treat several different types of B-cell non-Hodgkin's lymphoma. Monoclonal antibodies are used to try to destroy some types of cancer cells, while causing little harm to normal cells. They are designed to recognise and attach themselves (like a key in a lock) to certain proteins that are found on the surface of some cancer cells. This may then trigger the body’s immune system to attack the cancer cells and can sometimes cause the cells to destroy themselves. Rituximab locks onto a protein called CD20, which is found on the surface of one of the main types of normal white blood cells (B-cell lymphocytes). It is also present on the surface of most of the abnormal B-cell lymphocytes that occur in some types of non-Hodgkin's lymphoma. Rituximab acts by attacking both abnormal (malignant) and normal B-cell lymphocytes. However, the body can quite quickly replace any normal white blood cells that are damaged. acgt:ESV End-systolic volume (ESV) is the volume of blood in the left ventricle at the end of contraction, or systole, and the beginning of filling, or diastole. End systolic volume can be used clinically as a measurement of the adequacy of cardiac emptying, related to systolic function. acgt:EU-RHABIdentificationNumber Identification Number according to the European Rhabdoid Study acgt:Echocardiography acgt:EighthThroracicVertebra acgt:Elbow acgt:Electron acgt:EleventhThroracicVertebra acgt:EligibilityCriterion aka inclusion criterion acgt:EmergencySurgery acgt:EmergencySurgeryRole acgt:Enanthema acgt:EndOfBloodPressureMeasuringProcess acgt:EndOfBloodPressureRecordingProcess acgt:EndOfConcentrationMeasuringProcess acgt:EndOfCranialPressureMeasuringProcess acgt:EndOfDensityMeasuringProcess acgt:EndOfFrequencyMeasuringProcess acgt:EndOfFrequencyRecordingProcess acgt:EndOfPressureMeasuringProcess acgt:EndOfPressureRecordingProcess acgt:EndOfRoomPressureMeasuringProcess acgt:EndOfRoomPressureRecordingProcess acgt:EndOfTirePressureMeasuringProcess acgt:EndOfTirePressureRecordingProcess acgt:EndOfWeightMeasuringProcess acgt:EndOfWeightRecordingProcess acgt:EndSystolicWallStressLevel acgt:EndocrineSystemSymptom acgt:EndoscopicBiopsy acgt:Energy acgt:Engraftment Def.: The Organismal Process of acceptence of new donor stem cells or bone marrow by an organism. The process is indicated by the production of new blood cells acgt:Enucleation acgt:Enzyme acgt:EpigastricTransverseIncision acgt:Epirubicin acgt:EpirubicinCycle acgt:EpithelialNephroblastoma acgt:Epitheliolysis acgt:ErythemaDevelopment acgt:ErythrocyteTransfusion acgt:Erythropoietin acgt:ErythropoietinLevel acgt:EthicsCommittee acgt:EthicsInstitute acgt:Etoposide acgt:EtoposideCisplatinChemo The chemotherapy drugs used in this treatment are etoposide (pronounced e-top-o-side) and cisplatin (sis-pla-tin). acgt:ExcisionalBiopsy aka Tumorectomy; an "excisional biopsy" (sometimes called a "tumorectomy") is the removal of a tumor with a minimum of healthy tissue. It is therefore an excision rather than a biopsy. acgt:ExclusionCriterion acgt:Experiment acgt:ExternalOtitis acgt:ExtraOrganismalIndependenContinuant acgt:ExtraabdominalLymphNode 0 acgt:ExtrapyramidalMotorSystem acgt:Extraregional acgt:ExtrarenalPrimaryTumor acgt:FECChemo FEC is named after the initials of the chemotherapy drugs used, which are fluorouracil (pronounced floo-ro-you-ro-sill), which is also known as 5FU, epirubicin (epi-roo-biss-sin) and cyclophosphamide (sigh-clo-fos-fa-mide). acgt:Face acgt:FacialNerve acgt:FatherRole acgt:FaxNumber acgt:FeasibilityLevel acgt:Feasible acgt:Female acgt:FemaleGenitalSystemSymptom 0 0 0 acgt:FemaleHumanBeing 0 acgt:Fever acgt:FeverGrade acgt:FeverGrade0 acgt:FeverGrade1 acgt:FeverGrade2 acgt:FeverGrade3 acgt:FeverGrade4 acgt:Fibrosis acgt:FieldOfVision acgt:FifthCervicalVertebra acgt:FifthLumbarVertebra acgt:FifthSacralVertebra acgt:FifthThroracicVertebra 0 acgt:FillingInCaseReportForm acgt:FineNeedleBiopsy aka Aspiration or FNA biopsy acgt:FirstCoccygealVertebra acgt:FirstLumbarVertebra acgt:FirstName acgt:FirstSacralVertebra acgt:FirstStemCellHarvesting acgt:FirstThroracicVertebra acgt:FlowCytometry acgt:FocalAnaplasia acgt:FocalAnaplasticNephroblastoma 0 acgt:Fontanelle acgt:Foot acgt:Forearm acgt:ForeignPrimaryTherapy acgt:FourthCervicalVertebra acgt:FourthCoccygealVertebra acgt:FourthLumbarVertebra acgt:FourthSacralVertebra acgt:FourthThroracicVertebra 0 acgt:FreeLimb acgt:FreeLimbSegment 0 acgt:FreeLowerLimb acgt:FreeLowerLimbSegment 0 acgt:FreeUpperLimb acgt:FreeUpperLimbSegment acgt:Frequency acgt:FrequencyRecordingProcess acgt:FrequencyUnit acgt:FuhrmanNuclearGrade used for kidney cancer acgt:FullName acgt:FunctionalOrStructural acgt:FundingInstitution acgt:Furosemide acgt:FurtherTherapy NG: Further treatment in another clinic means, if a hospital makes the diagnosis of cancer and only starts to treat and then referes the patient to another hospital, then further treatment is given in another clinic. Further treatment can be protocol treatment and non-protocol treatment. E.g. it can be protocol treatment in another hospital but protocol treatment. But it can also be other treatment. It has to be specified in the CRFs comments. acgt:GPOH-PID acgt:GemCapChemo GemCap is named after the drugs used and involves the chemotherapy drugs: gemcitabine (pronounced jem-sight-a-been), which is also known as Gemzar® and capecitabine (cap-sight-a-been), also known as Xeloda® (ze-load-a). acgt:GemCarboChemo GemCarbo is named after the chemotherapy drugs used in the treatment, which are gemcitabine (pronounced gem-sight-a-been), which is also known as Gemzar® and carboplatin (car-bo-pla-tin). acgt:GemTaxolChemo GemTaxol is named after the chemotherapy drugs used, which are gemcitabine (pronounced gem-sight-a-been), which is also known as Gemzar®, and paclitaxel (pak-li-tax-el), which is commonly called Taxol (tax-ol). acgt:GemicitabineCisplatinChemo The treatment involves the two chemotherapy drugs gemcitabine (pronounced gem-sight-a-been), which is also known as Gemzar®, and cisplatin (sis-pla-tin). acgt:Gender acgt:GeneExpression FMA? acgt:GeneTherapy acgt:GeneralHealthRating acgt:GeneralHospital acgt:GeneralPractitioner acgt:GeneralSurgeon acgt:GeneralizedSymptom acgt:GeneticDelationMutation acgt:GeneticMutation acgt:Geneticist acgt:GenitalSystemSymptom acgt:GenomicType genomic type of a tumor acgt:GleasonDifferentiation used for prostate cancers; Gleason score = a system of grading prostate cancer tissue based on how it looks under a microscope. Gleason scores range from 2 to 10 and indicate how likely it is that a tumor will spread. A low Gleason score means the cancer tissue is similar to normal prostate tissue and the tumor is less likely to spread; a high Gleason score means the cancer tissue is very different from normal and the tumor is more likely to spread. acgt:GleasonGrade10 acgt:GleasonGrade2 acgt:GleasonGrade3 acgt:GleasonGrade4 acgt:GleasonGrade5 acgt:GleasonGrade6 acgt:GleasonGrade7 acgt:GleasonGrade8 acgt:GleasonGrade9 0 acgt:Glomerulopathy acgt:GlossopharyngealNerve acgt:GnRHAnalog GnRH = gonadotropin releasing hormone acgt:GranularLeucocyte acgt:GranularLeucocyteGrade acgt:GranularLeucocyteGrade0 acgt:GranularLeucocyteGrade1 acgt:GranularLeucocyteGrade2 acgt:GranularLeucocyteGrade3 acgt:GranularLeucocyteGrade4 acgt:GranulocyteColonyStimulatingFactor aka GCSF; Granulocyte Colony-Stimulating Factor (G-CSF or GCSF) is a hormone. It is a glycoprotein, growth factor or cytokine produced by a number of different tissues to stimulate the bone marrow to produce granulocytes and stem cells. G-CSF then stimulates the bone marrow to pulse them out of the marrow into the blood. It also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils. acgt:GranulocytopeniaGrade acgt:GranulocytopeniaGrade0 acgt:GranulocytopeniaGrade1 acgt:GranulocytopeniaGrade2 acgt:GranulocytopeniaGrade3 acgt:GranulocytopeniaGrade4 acgt:Granuloma 0 acgt:GrossMotorSkills acgt:Gynecologist acgt:HGFStemCellMobilisation acgt:HITChemotherapyRegime Chemotherapy Regime according to the "Hirntumorstudien" acgt:HRT Hormone Replacement Therapy (HRT) is medication containing one or more female hormones, commonly estrogen plus progestin (synthetic progesterone). acgt:HaematooncologicalTumor acgt:Haematooncologist acgt:Hand acgt:HbTest hemoglobin? acgt:Head 0 acgt:Headache 0 acgt:Hearing acgt:HearingDevice acgt:HearingLoss acgt:HearingLoss16To30dB acgt:HearingLoss31To60dB acgt:HearingLossGreater60dB acgt:HearingLossLess15dB 0 acgt:Heart acgt:HeartFunctionGrade acgt:HeartFunctionGrade0 definition: Normal function, shortening fraction >30% acgt:HeartFunctionGrade1 definition: Asymptomatic decline resting ejection fraction of >10% but <20% of baseline value, shortening fraction >25% but <30% acgt:HeartFunctionGrade2 definition: Asymptomatic decline resting ejection fraction of >20% but <25% of baseline value, shortening fraction >20% but <25% acgt:HeartFunctionGrade3 definiton: Congestive heart failure responsive to treatment, shortening fraction >15% but <20% acgt:HeartFunctionGrade4 definition: Severe or refractory congestive heart failure or requiring intubation, shortening fraction <15% 0 acgt:HeartFunctioning The processes that implement the canonical functioning of the heart. 1 acgt:HeartRate acgt:HeartSurgeon acgt:Height acgt:HemalCell acgt:HematologicalBiochemicalTest aka WBC acgt:HematologicalDisease acgt:HematologicalDiseaseProcess acgt:HematologicalGrowthFactor acgt:HematologicalMalignancy acgt:HematologicalMalignancyProcess acgt:HematopoieticSystem acgt:Hematotoxicity 0 acgt:Hematuria acgt:HematuriaGrade acgt:HematuriaGrade0 acgt:HematuriaGrade1 acgt:HematuriaGrade2 acgt:HematuriaGrade3 acgt:HematuriaGrade4 acgt:HemiHypertrophy acgt:HemiHypertrophyProcess 0 acgt:Hemiparesis acgt:Hemoglobin acgt:HemoglobinConcentration acgt:HemoglobinGrade acgt:HemoglobinGrade0 acgt:HemoglobinGrade1 acgt:HemoglobinGrade2 acgt:HemoglobinGrade3 acgt:HemoglobinGrade4 acgt:HemolymphoidSystemSymptom acgt:HemorrhageGrade acgt:HemorrhageGrade0 acgt:HemorrhageGrade1 acgt:HemorrhageGrade2 acgt:HemorrhageGrade3 acgt:HemorrhageGrade4 acgt:HepaticVeinOcclusion acgt:HepatoToxicity acgt:Herceptin acgt:Hernia acgt:HeterogeneousCluster acgt:HighCeilingLoopDiuretic acgt:HighDoseTherapy acgt:HighRiskBlastemaRichNephroblastoma acgt:HighRiskNephroblastoma acgt:Hip 0 acgt:HistologicalExamination acgt:HistologicalSample sample of tissue sectioned as a thin slice acgt:HistologicalType should have child HistopathologicalType? acgt:HistopathologicTypeAssessment acgt:HomogenousTumor acgt:HormonalTreatment acgt:Hormone acgt:HormoneTherapyDrug acgt:Hospital acgt:HospitalConsentForm acgt:HospitalIdentifier 1 acgt:Hour acgt:HouseNumber 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 acgt:HumanBeing acgt:HumanBody acgt:Hydrochlorothiazide 0 acgt:Hypertension acgt:Hypertonia acgt:HypertoniaProcess acgt:HypoglossalNerve 0 acgt:Hypotension acgt:Hysterectomy acgt:ICC aka Immunocytochemistry; Immunocytochemistry differs from immunohistochemistry (IHC) in that the former is performed on samples of intact cells that have had most, if not all, their surrounding extracellular matrix removed. acgt:ICDClass acgt:ICDOClass acgt:ICEChemo Def. A chemotherapy based on Ifosfamide, Carboplatin and Etoposide. acgt:IHC aka Immunohistochemical staining acgt:IMBEIIdentifier acgt:ITCompany acgt:ITInstitute acgt:Idarubicin 1 acgt:Identifier acgt:Ifosfamide acgt:Iliopsoas acgt:Image 1 acgt:Imaging acgt:ImmaterialOrganismalIndependentContinuant 0 acgt:ImmuneDeficiency acgt:ImmunoEM aka Immuno-electron microscopy acgt:ImmunohistochemicalExamination 0 0 acgt:Immunoreaction acgt:Immunostaining acgt:Immunotherapy acgt:ImmunotherapyDrug acgt:Implant acgt:ImplantObject acgt:IncisionalHernia acgt:InclusionCriterion acgt:Incomplete acgt:IncompleteParaplegia acgt:IncreasedCatecholaminLevel acgt:InducedAbortion acgt:Infarction acgt:Infection acgt:InfectionGrade acgt:InfectionGrade0 no infection acgt:InfectionGrade1 mild infection acgt:InfectionGrade2 medium infection; agent not identified acgt:InfectionGrade3 heavy infection; agent identified acgt:InfectionGrade4 acgt:InfectiousDisease acgt:InfectiousDiseaseProcess acgt:InferiorRenalSegment acgt:Infiltration acgt:Inflammation acgt:InflammatoryCarcinoma 1 acgt:InformationObject acgt:InformedWrittenConsenting acgt:InfrahepaticNephroblastomaSpread acgt:Infusion acgt:InhomogenousTumor acgt:Inking acgt:Institute 0 0 acgt:Institution Best would be to replace "Institution hasIdentifier some InstitutionIdentifier" with "Institution hasIdentifier min 0 InstitutionIdentifier," however that is a QCR, and would probably generate OWL issues. As such, the constraint may be factually inaccurate, though certainly accurate and useful in ACGT context. acgt:InstitutionIdentifier acgt:InsuranceCompany acgt:Intact acgt:Intactness acgt:IntensiveCareRequiredState 0 acgt:IntentionTremor acgt:IntentionalProcess acgt:IntergumentarySystemSymptom acgt:IntermediateRiskBlastemaRichNephroblastoma acgt:IntermediateRiskNephroblastoma acgt:InternalEar acgt:Internist acgt:IntestinalInfarction acgt:IntestinalLesion acgt:IntracardiacNephroblastomaSpread acgt:IntracellReceptor Intracellular receptors are receptors located inside the cell rather than on its cell membrane. 0 acgt:IntracranialPressure acgt:Invagination acgt:InvasiveDuctalCarcinoma aka "no special type" acgt:InvasiveDuctalCarcinomaAssessment acgt:InvasiveLobularCarcinoma acgt:InvasiveLobularCarcinomaAssessment acgt:InvasiveMammaryCarcinoma acgt:InvestigatorNewsletter acgt:IonizingRadiation acgt:IrinotecanWithDeGramontChemo This treatment involves the following chemotherapy drugs irinotecan (pronounced eye-ri-no-tee-can), fluorouracil (floo-ro-you-ro-sill), which is also known as 5FU, and a drug called folinic (fol-in-ic) acid, which is also known as leucovorin (loo-co-vor-rin). Folinic acid makes 5FU more effective. 5FU and folinic acid are commonly given together to treat bowel cancer. The combination of these two drugs can be given in different ways, and is often known as the 'de Gramont' regime, or modified de Gramont. When irinotecan is given with de Gramont it is sometimes called FOLFIRI. When irinotecan is given with modified de Gramont, it may be called IrMdG. acgt:IrregularBone acgt:Isodose Def.: An isodose is a two-dimensional region (a surface or a line) that covers all point of the same energy dose or ionic dose. acgt:Issuing 1 acgt:JournalNumber Number a pathologist assigns to a case. If more than on histologies of a single patient are examined, each histological specimen gets its own JournalNumber. acgt:Jurist acgt:KarnofskyRating http://en.wikipedia.org/wiki/Performance_status acgt:KarnofskyScore0 dead acgt:KarnofskyScore10 moribund, rapidly progressive fatal disease processes acgt:KarnofskyScore100 normal, no complaints, no signs of disease acgt:KarnofskyScore20 very ill, urgently requiring admission, requires supportive measures or treatment acgt:KarnofskyScore30 severely disabled, hospital admission indicated but no risk of death acgt:KarnofskyScore40 disabled, requires special care and help acgt:KarnofskyScore50 requires help often, requires frequent medical care acgt:KarnofskyScore60 requiring some help, can take care of most personal requirements acgt:KarnofskyScore70 caring for self, not capable of normal activity or work acgt:KarnofskyScore80 normal activity with some difficulty, some symptoms or signs acgt:KarnofskyScore90 capable of normal activity, few symptoms or signs of disease 0 acgt:Kidney 0 acgt:KidneyFunctioning The processes that implement the canonical functioning of the kidney. acgt:Kinase acgt:Knee acgt:LCIS acgt:LCISHistologicalAssessment acgt:LH-RH LH-RH means Luteinizing Hormone-Releasing Hormone. It is a Releasing hormone, i.e. a hormone whose main purpose is to control the release of another hormone, here the Luteinizing hormone. acgt:LHRHAnalog acgt:LHRHAnalogTreatment 1 acgt:LVEF Left Ventricular Ejection Fraction 1 acgt:LVSF Shortening Fraction Of The Left Ventricle acgt:LVSFGrade acgt:LVSFGrade0 acgt:LVSFGrade1 acgt:LVSFGrade2 acgt:LVSFGrade3 acgt:LVSFGrade4 acgt:Labor acgt:Laboratory acgt:Lactation acgt:LanskyRating http://en.wikipedia.org/wiki/Performance_status acgt:LanskyScore0 unresponsive acgt:LanskyScore10 doesn't play; does not get out of bed acgt:LanskyScore100 fully active, normal acgt:LanskyScore20 sleeping often; play entirely limited to very passive activities acgt:LanskyScore30 bedbound; needing assistance even for quiet play acgt:LanskyScore40 mainly in bed; participates in quiet activities acgt:LanskyScore50 lying around much of the day, but gets dressed; no active playing participates in all quiet play and activities acgt:LanskyScore60 up and around, but active play minimal; keeps busy by being involved in quieter activities acgt:LanskyScore70 greater restriction of play and less time spent in play activity acgt:LanskyScore80 active, but tired more quickly acgt:LanskyScore90 minor restrictions in strenuous physical activity acgt:LastName acgt:LateComplication acgt:Lateness acgt:Laterality acgt:Lawyer acgt:LeftHemiparesis acgt:LeftKidneyAnteriorInferiorRenalSegment acgt:LeftKidneyAnteriorSuperiorRenalSegment acgt:LeftKidneyInferiorRenalSegment acgt:LeftKidneyPosteriorRenalSegment acgt:LeftKidneySuperiorSegment acgt:Leg acgt:LegalGuardianIdentifier acgt:LegalGuardianRole acgt:Length ? acgt:Lens acgt:Lesion acgt:Leucocyte acgt:LeucocyteGrade acgt:LeucocyteGrade0 acgt:LeucocyteGrade1 acgt:LeucocyteGrade2 acgt:LeucocyteGrade3 acgt:LeucocyteGrade4 acgt:Leukemia acgt:LeukemiaProcess acgt:LeukopeniaGrade acgt:LeukopeniaGrade0 acgt:LeukopeniaGrade1 acgt:LeukopeniaGrade2 acgt:LeukopeniaGrade3 acgt:LeukopeniaGrade4 acgt:Life 0 acgt:Limb acgt:LimbSegment 0 acgt:LinearParticleAccelerator acgt:LinearUnit acgt:Lipid acgt:LiquorDrainage acgt:Liver acgt:LiverLesion acgt:Lobectomy acgt:LobularOrgan acgt:LocalPathologist acgt:LocalRadiologist acgt:LocalRadiotherapist acgt:LocalTumorRelapse acgt:LocallyAdvancedSituation acgt:Lomustine acgt:LongitudinalIncision Längsschnitt? 0 acgt:LostToFollowUp 0 acgt:LowCertainty acgt:LowRiskNephroblastoma acgt:LowerLimb acgt:LumarVertebra acgt:LumbarCerebrospinalFluidPuncture acgt:Lumpectomy 0 acgt:Lung 0 acgt:LymphNode 0 acgt:LymphNodeDissection acgt:M0 definition: No distant metastasis acgt:M1 definition: Distant metastasis (includes metastasis to ipsilateral supraventricular lymph node[s]) acgt:MClass definition: Distant metastasis classification acgt:MICChemo MIC is named after the initials of the chemotherapy drugs used, which are mitomycin (pronounced my-toe-my-sin), ifosfamide (i-foss-fa-mide) and cisplatin (sis-pla-tin). acgt:MMChemo MM is named after the initials of the chemotherapy drugs used, which are methotrexate (pronounced me-tho-trex-ate) and mitoxantrone (my-toe-zan-trone). Sometimes the term MM may be used to describe a combination of mitomycin and mitoxantrone. Our cancer support service nurses can give you further information about this regimen. acgt:MMMChemo MMM is named after the initials of the chemotherapy drugs used, which are mitomycin (pronounced my-toe-my-sin), methotrexate (me-tho-trex-ate) and mitozantrone (my-toe-zan-trone). acgt:MRT Rhabdoid tumor in soft tissue (except kidney) MRT is short for Malign Rhabdoid Tumor acgt:MTXChemo acgt:MUGAScan acgt:MVPChemo MVP is named after the chemotherapy drugs used in the treatment, which are mitomycin (pronounced my-toe-my-sin), vinblastine (vin-blas-teen) and cisplatin (sis-pla-tin). acgt:MX definition: Presence of distant metastasis cannot be assessed acgt:MacropathologicalExamination acgt:MacrophageGranulocyteColonyStimulatingFactor acgt:MaddenMastectomy 0 acgt:MagneticResonanceImaging acgt:Magnitude acgt:MaidenName acgt:MajorRupture acgt:Male acgt:MaleGenitalSystemSymptom acgt:MaleHumanBeing 0 0 1 0 0 0 0 0 0 0 0 acgt:Malfunction 0 0 0 0 0 0 0 0 0 acgt:MalignNeoplasm 0 acgt:Malignancy acgt:MalignancyRelatedDiagnosticProcess 1 acgt:MammaryCarcinoma acgt:MammaryCarcinomaClass acgt:Mannitol acgt:Marker aka indicator 0 acgt:Mask acgt:MassUnit acgt:Mastectomy acgt:Mastopexy 0 0 0 0 0 0 0 0 acgt:MaterialOrganismalIndependentContinuant acgt:Mathematician acgt:Maximum acgt:MayoChemo The Mayo regime (named after the hospital that started it) involves the drugs fluorouracil (pronounced floo-ro-you-ro-sill), which is a chemotherapy drug sometimes known as 5FU, and folinic (fol-in-ic) acid, which is a drug that makes 5FU more effective. It is also known as leucovorin (loo-co-vor-rin) or LV. 5FU and folinic acid are commonly used in the treatment of bowel cancer. It is important to know that the two drugs are often used together in different ways. This information is specifically about the Mayo regimen. acgt:MeasurementUnit acgt:MeasuringProcessEnd acgt:MeasuringProcessStart acgt:MedialOtitis acgt:Mediastinum acgt:MedicalExpertIdentifier doctor´s name 0 0 acgt:MedicalImage acgt:MedicalPractitioner 0 0 0 1 1 0 0 1 acgt:MedicalProcess acgt:MedullaOblongata acgt:MedullaryCarcinoma acgt:MeningealCluster acgt:Menopause acgt:MenstrualCycle acgt:Menstruation acgt:MesenteryOfLargeIntestine Synonym: Mesocolon acgt:MesoblasticNephroma acgt:Metabolism acgt:MetabolismByproduct acgt:Metaplasia acgt:Metastasectomy acgt:Metastasis acgt:Methotrexat Abbr. MTX 2-Desoxy-4-amino-10-methyl folic acid acgt:MethotrexatLevel 1 acgt:Microarray acgt:MicroarrayExperiment acgt:MicroarrayHybridization acgt:MicropathologicalExamination acgt:MiddleCranialFossa acgt:MiddleFreeLimbSegment acgt:Midline acgt:Minimum acgt:MinorImpairmentState acgt:MinorRupture 1 acgt:Minute acgt:MirrorBlock acgt:Misscarriage = spontaneous abortion acgt:MixedCarcinoma acgt:MixedNephroblastoma acgt:MixedTumor acgt:MolecularBiologist acgt:MolecularBiologyTechnique acgt:MoleculargeneticExamination acgt:MonoZygotic 0 0 acgt:Monoparesis 1 acgt:Month acgt:MotherRole acgt:MotorNeuropathy acgt:MotorNeuropathyProcess 0 acgt:MotoricCoordination acgt:Mucosa acgt:Mucositis acgt:MultifocalAnaplasia acgt:MultipleFieldIrradiation acgt:MultipleTumors acgt:MuscleOfThorax acgt:MuscleOfTrunk acgt:MuscleOfVertebralColumn acgt:MuscleOrgan acgt:MusculoskeletalSystemSymptom 0 acgt:Myalgia acgt:N0 definition: No regional lymph node metastasis acgt:N1 definition: Metastasis to movable ipsilateral axillary lymph node(s) acgt:N2 definition: Metastasis to ipsilateral axillary lymph node(s) fixed to one another or to other structures acgt:N2a definition: Metastasis or Metastases to ipsilateral axillary lymph node(s) fixed to one another or to other structures acgt:N2b definition: Metastasis or Metastases to ipsilateral axillary lymph node(s) along the Arteria mammaria interna without clinically identifiable axillary lymph node metastases acgt:N3 definition: Metastasis to ipsilateral internal mammary lymph node(s) acgt:N3a definition: Metastasis or Metastases to ipsilateral infraclaviculary lymph node(s) acgt:N3b definition: Metastasis or Metastases to ipsilateral lymph node(s) along the Arteria mammaria with axillary lymph node metastases acgt:N3c definition: Metastasis or Metastases in ipsilateral supraclaviculary lymph node(s) acgt:NClass definition: Regional lymph node metastasis classification acgt:NX definition: Regional lymph nodes cannot be assessed (eg, previously removed) acgt:Nadir Def.: The role of the lowest measurement, e.g. of number of erythrocytes or thrombocytes. 1 acgt:Name acgt:NationalHospital acgt:NationalPrimaryTherapy acgt:NaturalProcess 0 acgt:Nausea acgt:Neck acgt:Necrosis acgt:NeoadjuvantChemotherapy acgt:NeoadjuvantTherapy Def.: Treatment that's given first to help make the next treatment step go more smoothly. For example, chemotherapy, radiation or hormones may be given before surgery. In breast cancer, this therapy is mainly used to shrink a large tumor so that it's easier to take out. 0 0 0 0 0 0 0 1 acgt:Neoplasm aka tumor acgt:Nephrectomy 0 1 acgt:Nephroblastoma 0 acgt:NephroblastomaSpread acgt:Nephroblastomatosis acgt:Nephrotoxicity acgt:NerveTrunk acgt:NervousSystemSymptom acgt:NeuralTreeOrgan acgt:Neuraxis Syn.: Central Nervous System acgt:NeuroSurgeon acgt:NeuroendocrineTumor 0 acgt:NeuroendocrinologicalProcess acgt:NeurologicalComplication acgt:NeurologicalExamination acgt:Neuropathy acgt:NeuropathyProcess 0 acgt:NeuropsychologicalProcess acgt:Neurotoxicity acgt:Neutropenia acgt:NeutropeniaProcess acgt:Neutrophil 0 acgt:NightSweating acgt:NinthThroracicVertebra acgt:NodalStatus acgt:NodalStatusAssessment acgt:NodalStatusNegative acgt:NodalStatusPositive acgt:NonAccidental acgt:NonInfectiousDisease acgt:NonInfectiousDiseaseProcess acgt:NonInvasiveMammaryCarcinoma Non-invasive aka "in situ" acgt:NonNucleatedCell acgt:NonNucleatedSolocyte acgt:NonParenchymatousOrgan acgt:Normal acgt:NormalActivityState acgt:NormalCatecholaminLevel 0 acgt:Normality acgt:NuclearImaging acgt:NucleatedCell acgt:NucleicAcid 1 acgt:NumberOfBloodCells 1 acgt:NumberOfCycles acgt:NumberOfGranularLeucocytes 1 acgt:NumberOfLatenessDays acgt:NumberOfLeucocytes 1 acgt:NumberOfLymphNodes acgt:NumberOfPlatelets 1 acgt:NumberOfStemCells acgt:NumberOfTumors acgt:Nurse acgt:NursingCare 0 acgt:Nystagmus acgt:Obstruction acgt:OculomotorNerve acgt:OffspringRole 1 acgt:OlfactoryNerve acgt:Ontologist acgt:OphtalmologicalDiagnosticProcess acgt:OpposingFieldIrradiation acgt:OpticChiasm acgt:OpticNerve acgt:OralMaintainanceChemo acgt:Organ acgt:OrganCluster acgt:OrganComponenentLayer acgt:OrganComponent acgt:OrganComponentOfNeuraxis acgt:OrganRegion acgt:OrganSegment acgt:OrganSystem acgt:OrganSystemSubdivision acgt:OrganWithCavitatedParts acgt:OrganWithOrganCavity acgt:OrganZone 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 acgt:Organism acgt:OrganismalEpilation 0 0 0 0 0 1 acgt:OrganismalIndependentContinuant acgt:OrganismalProcess acgt:OrganismalSpace acgt:OrganismalSurface acgt:OrthopaedicSurgeon acgt:OsmoticDiuretic acgt:Osteochondritits acgt:Otitis acgt:Otorinolaryngologist acgt:Ototoxicity acgt:Ovariectomy acgt:Overdosage acgt:Oxaliplatin5FUChemo The treatment involves two chemotherapy drugs, which are oxaliplatin (pronounced ox-ali-plat-in) and 5FU, which is also known as fluorouracil (floo-ro-you-ro-sill). They are given with a vitamin called folinic acid (leucovorin), which makes 5FU more effective. This combination of chemotherapy is sometimes referred to as the FOLFOX regimen, named after the drugs used. Some doctors may refer to the combination as oxaliplatin modified deGramont (OxMdG), when they give the drugs in a different order. acgt:PCR aka Gene Amplification acgt:PCVChemo PCV is named after the initials of the chemotherapy drugs used, which are procarbazine (pronounced pro-car-ba-zeen), lomustine (low-mus-teen), which is also known as CCNU®, and vincristine (vin-chris-teen). acgt:PMitCEBOChemo PMitCEBO is named after the initials of the drugs used, which are prednisolone (pronounced pred-ni-so-lone), which is a steroid, and the following chemotherapy drugs: mitoxantrone (my-toe-zan-trone), cyclophosphamide (sigh-clo-fos-fa-mide), etoposide (e-top-o-side), bleomycin (blee-o-my-sin) and vincristine (vin-chris-teen), which used to be known as Oncovin©. acgt:PR The progesterone receptor (PR) is an intracellular steroid receptor that specifically binds progesterone. acgt:PRHistologicalAssessment acgt:PRStatus aka Progesterone Receptor Status acgt:PaclitaxelCarboplatinChemo The treatment involves the two chemotherapy drugs paclitaxel (pronounced pak-li-tax-el), which is commonly known as Taxol, and carboplatin (car-bo-pla-tin). acgt:PaediatricHospital acgt:PaediatricOncologist acgt:PaediatricSurgeon acgt:Paediatrician acgt:PagetNippleTumor acgt:Pancreas acgt:PapillaryRenalCellCarcinoma 0 acgt:Papilledema acgt:Paramedic 0 acgt:Paraparesis 0 1 acgt:Paraplegia acgt:ParenchymatousOrgan acgt:ParentIdentifier acgt:ParentQuestionnaire acgt:ParentRole acgt:ParenteralFeeding acgt:PartialHysterectomy acgt:PartialMastectomy acgt:PartialNephrectomy acgt:PartialTumorRemission acgt:PartialTumorResection acgt:Parturition = the actual process of giving birth; labor+delivery acgt:PateyMastectomy acgt:PathologicClasspTNM Pathological classification (Postsurgical histopathological classification), designated pTNM. This is based on the evidence acquired before treatment, supplemented or modified by the additional evidence acquired from surgery and from pathological examination. The pathological assessment of the primary tumour (pT) entails a resection of the primary tumour or biopsy adequate to evaluate the highest pT category. The pathological assessment of the regional lymph nodes (pN) entails removal of nodes adequate to validate the absence of regional lymph node metastasis (pN0) and sufficient to evaluate the highest pN category. The pathological assessment of distant metastasis (pM) entails microscopic examination. acgt:PathologicalAdhesion acgt:PathologicalAnaplasia acgt:PathologicalDiastolicBloodPressure acgt:PathologicalFieldOfVision acgt:PathologicalFormation Def.: A MaterialOrganismalIndependentContiuant whic is not part of the canonical body. acgt:PathologicalOrganismalSpace acgt:PathologicalOrganismalSurface acgt:PathologicalVisualAcuity acgt:Pathologist acgt:PathologyQuestionnaire acgt:Patient 0 acgt:PatientAdmission acgt:PatientConsentForm 0 acgt:PatientEnrollment acgt:PatientIdentifier acgt:PatientLetter 1 1 acgt:PatientManagement acgt:PatientPosition acgt:PatientQuestionnaire acgt:PatientStatusSurvey acgt:Pelvis acgt:PemetrexedCisplatinChemo The treatment involves the two chemotherapy drugs pemetrexed (pronounced pem-a-trex-ed), which is also known as Alimta®, and cisplatin (sis-pla-tin). acgt:PerformanceRating acgt:Perineum acgt:PeripheralBloodSample acgt:PeripheralBloodStemCellSample acgt:PeripheralNeurotoxicity acgt:PeripheralNeurotoxicityGrade acgt:PeripheralNeurotoxicityGrade0 acgt:PeripheralNeurotoxicityGrade1 acgt:PeripheralNeurotoxicityGrade2 acgt:PeripheralNeurotoxicityGrade3 acgt:PeripheralNeurotoxicityGrade4 acgt:PerirenalAdiposeTissue acgt:PeritonealMesentery acgt:Peritoneum acgt:Perlman acgt:PerlmanProcess acgt:PerpheralProgenitorCellSample acgt:PharmaceuticalCompany 0 0 acgt:PharmaceuticalSubstance 0 0 acgt:Pharmacotherapy 1 acgt:PharmacotherapyCycle 0 acgt:PharmacotherapyRegime acgt:Philosopher 1 acgt:PhysicalMagnitude acgt:Physicist acgt:PhysiologicalAnaplasia acgt:Physiotherapy acgt:Pigmentation acgt:PituitaryGland Syn.: Hypophysis acgt:PlaceName 0 acgt:PlasterFrame acgt:Platelet Synonym: Thrombocyte acgt:PlateletAdhesion acgt:PlateletCount acgt:PlateletGrade acgt:PlateletGrade0 acgt:PlateletGrade1 acgt:PlateletGrade2 acgt:PlateletGrade3 acgt:PlateletGrade4 acgt:PleuralEffusion acgt:Pneumonectomy acgt:Pons acgt:Population acgt:PopulationSubgroup acgt:PortionOfSoftTissue Def.: The portion of tissue of a body that does not contain bones or bonelike material. acgt:PortionOfTissue acgt:PostalCode acgt:PosteriorRenalSegment acgt:PotassiumSparingDiuretic 1 acgt:PreClinicalResearch acgt:PreTherapy acgt:Pregnancy 1 acgt:PregnancyStatus acgt:PregnancyTest acgt:PrenatalCheckUp acgt:PrenatalDiagnosticProcess acgt:Pressure acgt:PressureUnit acgt:PrevertebralMuscle acgt:PrimaryClinicalStudy acgt:PrimaryClinicalStudyProtocol acgt:PrimaryTherapy acgt:PrimaryTumor acgt:PrimitiveNeuroectodermalTumor 0 acgt:ProcessEnd 0 acgt:ProcessOrigin acgt:ProcessStart acgt:ProfessionalRole acgt:ProgenitorCell acgt:ProgenitorCellSample acgt:ProgenitorRole acgt:ProphylacticCheckUp acgt:Proposition acgt:Prostate acgt:Protein acgt:ProteinMicroarray 0 acgt:Proteinuria acgt:ProteinuriaGrade acgt:ProteinuriaGrade0 acgt:ProteinuriaGrade1 acgt:ProteinuriaGrade2 acgt:ProteinuriaGrade3 acgt:ProteinuriaGrade4 acgt:Prothesis acgt:ProthesisObject 0 acgt:Protocol I'd rather put this one under Processes. acgt:ProtocolChange acgt:ProtocolDeviationRole acgt:ProtocolPatient acgt:ProximalFreeLimbSegment acgt:PsoasMajor acgt:PsoasMinor 1 acgt:PsychosocialCare acgt:Publication 0 acgt:PulmonaryEdema acgt:PulseRepetitionFrequency acgt:PunchBiopsy acgt:Purging A process of cleaining a biomedical sample of e.g. tumor cells. acgt:Pus acgt:Quadrantectomy acgt:QualityOfLifeQuestionnaire acgt:Quantum acgt:Questionnaire acgt:R0 definition: No residual tumor acgt:R1 definition: Microscopical residual tumor acgt:R2 definition: Macroscopical residual tumor acgt:RClass definition: residual tumor classification acgt:RFSDays RFSdays: Duration of relapse free survival Should be definable in terms of Relapse, end and start of ... acgt:RNA acgt:RTK Rhabdoid Tumor of the Kidney acgt:RX definition: Residual tumor cannot be assessed acgt:RadiationField acgt:RadiationFraction acgt:Radicality acgt:Radiologist acgt:RadiooncologicalHospital acgt:Radiotherapist 1 0 0 0 0 1 acgt:Radiotherapy 0 acgt:RadiotherapyPlanning 0 acgt:RadiotherapyRiskOrgan acgt:Randomisation 0 1 0 acgt:Reason acgt:ReasonForPatientEnrollment acgt:ReasonOfAdmission acgt:ReasonOfTherapyTermination acgt:ReceptorProtein acgt:ReconstructiveBreastSurgery 1 acgt:RecordingProcess i.e. the recording of data (medical data or whatnot) acgt:RecordingProcessEnd acgt:RecordingProcessStart acgt:Recruitment acgt:ReferencePathologist acgt:ReferenceRadiologist acgt:ReferenceRadiotherapist acgt:ReferenceRoentgenologicalImaging acgt:RegionOfAnteriorChest acgt:RegionOfDuraMater acgt:RegionOfOrganComponent acgt:RegionOfPectoralPartOfChest acgt:RegionOfPeritoneum acgt:RegionOfSerousMembrane acgt:RegionOfVascularTreeOrgan acgt:RegionOfVisceralPeritoneum acgt:Regional acgt:Regionality acgt:Registration acgt:RegistrationNumber acgt:RegistryIdentifier acgt:RegressiveTypeNephroblastoma acgt:RegularCheckup acgt:RelapseFreeSurvival This is not good as an organismal process anymore than Life is. This is more likely to be viewed as a role, however I don't think we can write simple restrictions for roles. acgt:RelativeRole acgt:RenalCellCarcinoma acgt:RenalSegment acgt:RenalVein acgt:ResearchInstitute acgt:ResearchProcess is similar to "investigation" in OBI acgt:Resection aka Excision acgt:ResectionLine acgt:RespiratorySystemSymptom acgt:ResponsibleITPerson acgt:RetrohepaticNephroblastomaSpread acgt:RhabdoidTumor acgt:RhabdoidTumorPredispositionSyndrom Abb.: RTPS acgt:RhabdoidTumorPredispositionSyndromProcess acgt:RightHemiparesis acgt:RightKidneyAnteriorInferiorRenalSegment acgt:RightKidneyAnteriorSuperiorRenalSegment acgt:RightKidneyInferiorRenalSegment acgt:RightKidneyPosteriorRenalSegment acgt:RightKidneySuperiorSegment acgt:RoentgenologicalImaging acgt:Rubex acgt:Rupture acgt:SERM Selective estrogen receptor modulators (SERMs) is a class of medication that acts on the estrogen receptor. acgt:SIOP2001ChemotherapyRegime acgt:SIOPRelevantHistory acgt:SIOPRelevantHistoryProcess acgt:SacralVertebra acgt:SalvageTherapy Def.: Role of a TherapeuticProcess aiming to create a positive result after a previous TherapeuticProcess did not show effect. acgt:Sarcoma acgt:SchirrousCarcinoma acgt:Scientist acgt:Scintigraphy acgt:Screening 1 acgt:Second acgt:SecondCoccygealVertebra acgt:SecondLookSurgicalProcess acgt:SecondLumbarVertebra acgt:SecondSacralVertebra acgt:SecondThroracicVertebra acgt:SecondaryBenignTumor acgt:SecondaryClinicalStudy acgt:SecondaryClinicalStudyProtocol 0 acgt:SecondaryMalignTumor acgt:SecondaryMetastasis 0 acgt:SecondaryTumor acgt:SegmentOfBrain acgt:SegmentOfHindbrain acgt:SegmentOfLargeInstestine acgt:SegmentOfMetencephalon acgt:SegmentOfNeuralTreeOrgan acgt:SegmentOfNeuraxis acgt:SegmentOfSkin acgt:SegmentOfVenousTreeOrgan acgt:SegmentalMastectomy acgt:SemiMalignNeoplasm 0 acgt:SensoryDisturbance acgt:SensoryNeuropathy acgt:SensoryNeuropathyProcess acgt:Sepsis acgt:SerousMembrane acgt:Serum acgt:SerumCreatinineConcentration acgt:SerumCreatinineTest acgt:SetOfBasalGanglia acgt:SetOfCellParts 0 acgt:SetOfCranialNerves acgt:SetOfHeterogeneousClusters acgt:SetOfNeuralTreeOrgans acgt:SetOfNeuraxisStructures acgt:SetOfNucleiOfNeuraxis acgt:SetOfOrgans acgt:SeventhCervicalVertebra acgt:SeventhThroracicVertebra acgt:SexHormone acgt:Shoulder acgt:SiblingRole 0 acgt:Sight The process of seeing. 0 acgt:Signing acgt:SingleTumor acgt:SiteEnrollment acgt:SixthCervicalVertebra acgt:SixthThroracicVertebra acgt:Skin 0 acgt:SkinEdema acgt:SkinHemorrhage acgt:SkinOfHead acgt:SkinResponse acgt:SkinResponseGrade acgt:SkinResponseGrade0 acgt:SkinResponseGrade1 acgt:SkinResponseGrade2 acgt:SkinResponseGrade3 acgt:SkinResponseGrade4 acgt:SkinSparingTotalMastectomy acgt:Skull acgt:SocioEconomicQuestionnaire acgt:SolidOrgan acgt:SomaticCell acgt:Somnolence acgt:SpecializedHospital acgt:SpecificSymptom acgt:SpinalAccessoryNerve Syn.: AccessoryNerve acgt:SpinalCord acgt:Spironolactone acgt:Spleen acgt:SpleenLesion acgt:SputumExam acgt:StandardPartialNephrectomy acgt:StartOfBloodPressureMeasuringProcess acgt:StartOfBloodPressureRecordingProcess acgt:StartOfDensityMeasuringProcess acgt:StartOfDensityRecordingProcess acgt:StartOfFrequencyMeasuringProcess acgt:StartOfFrequencyRecordingProcess acgt:StartOfLengthMeasuringProcess acgt:StartOfPatientTemperatureRecordingProcess acgt:StartOfPressureMeasuringProcess acgt:StartOfPressureRecordingProcess acgt:StartOfRoomPressureMeasuringProcess acgt:StartOfRoomPressureRecordingProcess acgt:StartOfRoomTemperatureRecordingProcess acgt:StartOfSampleTemperatureRecordingProcess acgt:StartOfTemperatureMeasuringProcess acgt:StartOfTemperatureRecordingProcess acgt:StartOfTirePressureMeasuringProcess acgt:StartOfTirePressureRecordingProcess acgt:StateOfAffairs acgt:Statistician 1 acgt:StemCellHarvesting Syn: Stem Cell Collection Syn: Stem Cell Apharesis acgt:StemCellMobilisation 1 acgt:StemCellSample acgt:SteroidHormoneReceptor Steroid hormone receptors are intracellular receptors (typically cytoplasmic) that perform signal transduction for steroid hormones. acgt:Stomatitis acgt:StomatitisGrade0 acgt:StomatitisGrade1 acgt:StomatitisGrade2 acgt:StomatitisGrade3 acgt:StomatitisGrade4 acgt:StomatitsGrade acgt:StoringOfHistoSample acgt:StreetName acgt:StressLevel acgt:StromaRichNephroblastoma acgt:StructuralGene acgt:StuartBrasSyndrome acgt:StuartBrasSyndromeProcess acgt:StudyCommittee acgt:StudyNurse acgt:Stupor acgt:SubcutaneousMastectomy acgt:SubdivisionOfAbdomen acgt:SubdivisionOfBodyProper acgt:SubdivisionOfCardinalBodyPart acgt:SubdivisionOfCavityOfOrganSystemSubdivision acgt:SubdivisionOfCranialDuraMater acgt:SubdivisionOfHead acgt:SubdivisionOfHemolymphoidSystem acgt:SubdivisionOfInferiorVenaCavalTree acgt:SubdivisionOfPectoralGirdle acgt:SubdivisionOfPelvicGirdle acgt:SubdivisionOfSkeletalSystem acgt:SubdivisionOfSuperiorVenaCavalTree acgt:SubdivisionOfThoracicCompartment acgt:SubdivisionOfThorax acgt:SubdivisionOfTrunk acgt:SubdivisionOfTrunkProper 0 0 acgt:SubstanceSample acgt:SubtotalTumorResection acgt:SuctionAssistedCoreBiopsy acgt:Suicide acgt:SuperiorRenalSegment acgt:SupportingTherapy acgt:SupportivePharmacotherapy acgt:SuprahepaticNephroblastomaSpread acgt:SurfaceBiopsy acgt:SurfaceSize acgt:SurfaceUnit acgt:Surgeon acgt:SurgicalApproach 0 0 acgt:SurgicalOperation acgt:SurgicalProcedure acgt:SurgicalSuture acgt:Surveillance acgt:Suspicious acgt:Suspiciousness acgt:SuturalJunction acgt:Symptom acgt:Syndrome or is it under qualities or processes? acgt:SyndromeProcess acgt:Systemic acgt:SystemicNonInfectiousDisease acgt:SystemicNonInfectiousDiseaseProcess acgt:SystemicVein acgt:SystolicBloodPressure acgt:T0 definition: No evidence of primary tumor acgt:T1 definition: Tumor 2 cm or less in greatest dimension acgt:T1a definition: Tumor not more than 0.5 cm in greatest dimension acgt:T1b definition: Tumor more than 0.5 cm but not more than 2 cm in greatest dimension acgt:T1c definition: Tumor more than 1 cm but not more than 2 cm in greatest dimension acgt:T1mic definition: Microinvasion 0,1 cm or less in greatest dimension acgt:T2 definition: Tumor more than 2 cm but not more than 5 cm in greatest dimension acgt:T3 definition: Tumor more than 5 cm in greatest dimension acgt:T4 definition: Tumor of any size with direct extension to chest wall or skin acgt:T4a definition: Tumor with extension to chest wall acgt:T4b definition: Tumor with edema (including peau d’orange) or ulceration of the skin or satellite skin nodules confined to same breast acgt:T4c definition: Tumor with extension to chest wall and edema (including peau d’orange) or ulceration of the skin or satellite skin nodules confined to same breast acgt:T4d definition: Inflammatory carcinoma acgt:TACChemo TAC is named after the initials of the chemotherapy drugs involved, docetaxel (pronounced doe-se-tax-el), which is commonly known as Taxotere®, doxorubicin (docks-o-rou-bi-sin), which was originally called Adriamycin® and cyclophosphamide (sigh-clo-fos-fa-mide). acgt:TClass definition: Primary tumor classification acgt:TEOralMaintainanceChemo acgt:TIOralMaintainanceChemo acgt:TMZOralMaintainanceChemo acgt:TX definition: Primary tumor cannot be assessed acgt:Tabagism acgt:TabagismProcess acgt:Tamoxifen acgt:TandemChemotherapy acgt:Taxotere acgt:TechnicalObject Def.: Any object developed and put together to serve a clearly outlined purpose. acgt:Teleangiectasia 1 acgt:TelephoneNumber acgt:Teletherapy acgt:Temozolomide acgt:TenthThroracicVertebra acgt:TentoriumCerebelli 0 acgt:Tetraparesis aka "Quadriplegia" acgt:Thalamus 0 0 0 1 acgt:TherapeuticProcess Therapy in general. aka treatment old name: TherapeuticProcedure acgt:Therapy Def.: Role of a SurgicalProcess aiming to remove a tumor after a previous biopsy. acgt:TherapyAim 0 acgt:TherapyDelay 1 acgt:TherapyPlan acgt:TherapyTermination Def.: The process terminating a Therapeutic Process at an unforeseen time due to medical or adminstrative reasons. acgt:Thiazide acgt:Thickness acgt:Thigh acgt:ThirdCervicalVertebra acgt:ThirdCoccygealVertebra acgt:ThirdLumbarVertebra acgt:ThirdSacralVertebra acgt:ThirdThroracicVertebra acgt:ThoracicSurgeon acgt:ThoracicVertebra acgt:ThoracoAbdominalApproach acgt:Thorax acgt:ThrombocyteTransfusion acgt:ThrombocytopeniaGrade acgt:ThrombocytopeniaGrade0 acgt:ThrombocytopeniaGrade1 acgt:ThrombocytopeniaGrade2 acgt:ThrombocytopeniaGrade3 acgt:ThrombocytopeniaGrade4 0 acgt:Thrombosis acgt:Thrombus 0 acgt:Thyroid acgt:Tis definition: Carcinoma in situ: Intraductal carcinoma, lobular carcinoma in situ, or Paget’s disease of the nipple with no tumor acgt:TisDCIS definition: Intraductal carcinoma acgt:TisLCIS definition: lobular carcinoma in situ acgt:TisPaget definition: Paget’s disease of the nipple with no tumor acgt:TissueMicroarray acgt:TissueSample acgt:TotalBilirubin acgt:TotalBilirubinTest acgt:TotalHysterectomy acgt:TotalMastectomy acgt:TotalNephrectomy acgt:TotalRBC Total Red Blood Cells acgt:TotalTumorResection 0 acgt:Toxicity aplies primarily to drugs/pharmaceutical substance, i.e. toxicity type of a drug acgt:ToxicityLevel acgt:TransaminaseBiochemistry GOT/GPT acgt:TransfectionMicroarray acgt:Transfusion acgt:Transplant acgt:Transplantation acgt:TransversalApproach Transverser Zugang? acgt:TreatmentAssignment acgt:TreatmentCycle acgt:TriPletOrMultiPlet acgt:TrigeminalNerve acgt:TrochlearNerve acgt:Trofosfamide acgt:Troponin acgt:TroponinTest acgt:TrucutBiopsy 0 acgt:Trunk acgt:TubularCarcinoma 0 acgt:TubulesFunctioning The processes that implement the normal functioning of the renal tubules (tubuli renales). acgt:Tubulopathy 0 acgt:TumorCapsule acgt:TumorCell acgt:TumorCellCounting acgt:TumorClass acgt:TumorClassAssessment acgt:TumorDNASample acgt:TumorDevelopment acgt:TumorGradeAssessment acgt:TumorHomogeneity 0 acgt:TumorMarker acgt:TumorProgress acgt:TumorRNASample acgt:TumorRegression acgt:TumorRelapse acgt:TumorRemission 0 acgt:TumorResection 0 acgt:TumorSample acgt:TumorSituation 0 acgt:TumorStage acgt:TumorStagnation acgt:TwelfthThroracicVertebra acgt:TwinCount acgt:TwinGeneticType acgt:TwinType acgt:TwoPlet acgt:Ulceration acgt:Ultrasound 0 acgt:Unconsiousness acgt:Unfeasible acgt:Unilateral acgt:UnilateralOvariectomy acgt:UniversityHospital acgt:Unsuspicious acgt:UpperLimb acgt:Ureter acgt:UrinarySystemSymptom acgt:Urine acgt:UrineExam 0 acgt:UrineSample acgt:UrogenitalMalformation acgt:Urologist acgt:VADChemo VAD is named after the initials of the chemotherapy drugs used, which are vincristine (pronounced vin-chris-teen), doxorubicin (docks-o-rou-bi-sin), which was originally known as Adriamycin® and dexamethasone (decks-a-meth-a-sone), which is a steroid. acgt:VAPEC-BChemo VAPEC-B is named after the initials of the chemotherapy drugs used, which are vincristine (pronounced vin-chris-teen), doxorubicin (docks-o-rou-bi-sin), which was originally known as Adriamycin®, prednisolone (pred-ni-so-lone), which is a steroid, etoposide (e-top-o-side), cyclophosphamide (sigh-clo-fos-fa-mide) and bleomycin (blee-o-my-sin). acgt:VCDChemo A chemotherapy based on Vincristine, Cyclophosphamide and Doxorubin. acgt:VDChemo A chemotherapy based on Vincristine and Doxorubicin. 0 acgt:VacuumCushion acgt:VagusNerve acgt:VariantAnatomicalStructure I think we should get rid of this here, please consult Anads Ontology. I am unsure.... acgt:VascularLesion acgt:VascularSurgeon acgt:VascularSymptom 0 acgt:VegetativeFunctioning acgt:Vein acgt:VenaCavaObstruction acgt:VenaCavaProthesisObject acgt:VentricularCerebrospinalFluidPuncture acgt:VentriculoAtrialLiquorDrainage acgt:VentriculoPeritonealLiquorDrainage 0 acgt:Vertebra acgt:VertebralCanal Syn.: Spinal Canal acgt:VestibulocochlearNerve acgt:Vincristine acgt:VinorelbineCarboplatinChemo The treatment involves the two chemotherapy drugs vinorelbine (pronounced vin-or-ell-been), which is also known as Navelbine®, and carboplatin (car-bo-pla-tin). acgt:VinorelbineCisplatinChemo The chemotherapy drugs used are: vinorelbine (pronounced vi-nor-el-been), which is also known as Navelbine®, and cisplatin (sis-pla-tin), which is a platinum-based drug. acgt:ViralInfection acgt:ViralInfectionProcess acgt:ViscusSerousMembrane acgt:VisualAcuity acgt:Vital acgt:VitalityLevel acgt:Volume acgt:VolumeUnit 0 acgt:Vomiting acgt:VomitingGrade acgt:VomitingGrade0 acgt:VomitingGrade1 acgt:VomitingGrade2 acgt:VomitingGrade3 acgt:VomitingGrade4 acgt:WAGR acgt:WAGRProcess acgt:WBC CountingWhiteBloodCells acgt:WBCCount The number of leukocytes in the blood acgt:WallOfAbdomen acgt:WallOfOrgan acgt:Website acgt:WedgeResection 1 acgt:Week acgt:Weight acgt:WeightRecordingProcess acgt:WesternBlotting acgt:Width acgt:WiedemannBeckwithEMG acgt:WiedemannBeckwithEMGProcess acgt:WilmsTumorStage acgt:WilmsTumorStageI acgt:WilmsTumorStageII acgt:WilmsTumorStageIII acgt:WilmsTumorStageIV acgt:WilmsTumorStageV acgt:WindowTherapy Def: Role of a Therapy that is a) not tested and b) is done before the regular (well-established) Therapy. acgt:WoundDehiscence acgt:WoundInfection acgt:Wrist acgt:WrittenConsenting 1 acgt:Year acgt:Zoladex acgt:ZoneOfBoneOrgan acgt:pCRRate Pathological complete response is defined as the complete absence of intact tumour cells in the resected specimen. Not sure what difference may be between pCRRate and pCRStatus; for now, I've kept them both. 1 acgt:pCRStatus acgt:pM0 definition: No distant metastasis acgt:pM1 definition: Distant metastasis (includes metastasis to ipsilateral supraventricular lymph node[s]) acgt:pMClass acgt:pMX definition: Presence of distant metastasis cannot be assessed acgt:pN0 definition: No regional lymph node metastasis acgt:pN1 definition: Metastasis to movable ipsilateral axillary lymph node(s) acgt:pN1a definition: Only micrometastasis (none larger than 0.2 cm) acgt:pN1b definition: Metastasis to lymph nodes, any larger than 0.2 cm acgt:pN1c definition: Metastasis to a lymph node 2 cm or more in greatest dimension acgt:pN1mi definition: Micrometastasis greater than 0,2 mm but not more than 0,2 cm acgt:pN2 definition: Metastasis to ipsilateral axillary lymph nodes that are fixed to one another or to other structures acgt:pN2a definition: Metastases in 4 to 9 axillary lymph nodes, at least one metastasis greater than 0,2 cm in greatest dimension acgt:pN2b definition: Metastases to clinically identifiable lymph node(s) along the Arteria mammaria without axillary lymph node metastases acgt:pN3 definition: Metastasis to ipsilateral internal mammary lymph node(s) acgt:pN3a definition: Metastasis or Metastases in 10 or more ipsilateral axillary lymoh nodes, at least one greater than 0,2 cm or in ipsilateral infraclaviculary lymph nodes. acgt:pN3b definition: Metastasis or Metastases in clinically identifiable lymph nodes along the Arteria mammaria interna with at least one axillary lymph node metastasis or lymph node metastases in more than 3 axillary lymph nodes and in lymph nodes along the Arteria mammaria interna, proved by analysis of the sentinel lymph node(s) but not clinically identifiable acgt:pN3c definition: Metastasis or Metastases in ipsilateral supraclaviculary lymph nodes acgt:pNClass acgt:pNX definition: Regional lymph nodes cannot be assessed (eg, previously removed, or not removed for pathologic study) acgt:pT0 definition: No evidence of primary tumor acgt:pT1 definition: Tumor 2 cm or less in greatest dimension acgt:pT1a definition: Tumor not more than 0.5 cm in greatest dimension acgt:pT1b definition: Tumor more than 0.5 cm but not more than 2 cm in greatest dimension acgt:pT1c definition: Tumor more than 1 cm but not more than 2 cm in greatest dimension acgt:pT1mic definition: Microinvasion 0,1 cm or less in greatest dimension acgt:pT2 definition: Tumor more than 2 cm but not more than 5 cm in greatest dimension acgt:pT3 definition: Tumor more than 5 cm in greatest dimension acgt:pT4 definition: Tumor of any size with direct extension to chest wall or skin acgt:pT4a definition: Tumor with extension to chest wall acgt:pT4b definition: Tumor with edema (including peau d’orange) or ulceration of the skin or satellite skin nodules confined to same breast acgt:pT4c definition: Tumor with extension to chest wall and edema (including peau d’orange) or ulceration of the skin or satellite skin nodules confined to same breast acgt:pT4d definition: Inflammatory carcinoma acgt:pTClass acgt:pTX definition: Primary tumor cannot be assessed acgt:pTis definition: Carcinoma in situ: Intraductal carcinoma, lobular carcinoma in situ, or Paget’s disease of the nipple with no tumor acgt:pTisDCIS definition: Intraductal carcinoma acgt:pTisLCIS definition: lobular carcinoma in situ acgt:pTisPaget definition: Paget’s disease of the nipple with no tumor acgt:w-VDChemo acgt2:DRadiotherapyPlanning AT:RT Rhabdoid Tumor in the brain Short for Atypical Teratoid/Rhabdoid Tumor Def.: The magnitude of the activity level of T cells. NumberOfStemCellsX10ToThe4CD3:kg NumberOfStemCellsX10ToThe6CD34:kg NumberOfStemCellsX10ToThe8ANC:kg SGOT:SGPTGrade SGOT:SGPTGrade0 SGOT:SGPTGrade1 SGOT:SGPTGrade2 SGOT:SGPTGrade3 SGOT:SGPTGrade4 hSNF5:INI1 bfo:Entity entity snap:Continuant Definition: An entity [bfo:Entity] that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts. Examples: a heart, a person, the color of a tomato, the mass of a cloud, a symphony orchestra, the disposition of blood to coagulate, the lawn and atmosphere in front of our building Synonyms: endurant continuant snap:DependentContinuant Definition: A continuant [snap:Continuant] that is either dependent on one or other independent continuant [snap:IndependentContinuant] bearers or inheres in or is borne by other entities. dependent_continuant snap:Disposition Definition: A realizable entity [snap:RealizableEntity] that essentially causes a specific process or transformation in the object [snap:Object] in which it inheres, under specific circumstances and in conjunction with the laws of nature. A general formula for dispositions is: X (object [snap:Object] has the disposition D to (transform, initiate a process) R under conditions C. Examples: the disposition of vegetables to decay when not refrigerated, the disposition of a vase to brake if dropped, the disposition of blood to coagulate, the disposition of a patient with a weakened immune system to contract disease, the disposition of metal to conduct electricity. disposition snap:FiatObjectPart Definition: A material entity [snap:MaterialEntity] that is part of an object [snap:Object] but is not demarcated by any physical discontinuities. Examples: upper and lower lobes of the left lung, the dorsal and ventral surfaces of the body, the east side of Saarbruecken, the lower right portion of a human torso Synonyms: fiat substance part fiat_object_part snap:Function Definition: A realizable entity [snap:RealizableEntity] the manifestation of which is an essentially end-directed activity of a continuant [snap:Continuant] entity in virtue of that continuant [snap:Continuant] entity being a specific kind of entity in the kind or kinds of contexts that it is made for. Examples: the function of a birth canal to enable transport, the function of the heart in the body: to pump blood, to receive de-oxygenated and oxygenated blood, etc., the function of reproduction in the transmission of genetic material, the digestive function of the stomach to nutriate the body, the function of a hammer to drive in nails, the function of a computer program to compute mathematical equations, the function of an automobile to provide transportation, the function of a judge in a court of law function snap:GenericallyDependentContinuant Definition: A continuant [snap:Continuant] that is dependent on one or other independent continuant [snap:IndependentContinuant] bearers. For every instance of A requires some instance of (an independent continuant [snap:IndependentContinuant] type) B but which instance of B serves can change from time to time. Examples: a certain PDF file that exists in different and in several hard drives generically_dependent_continuant 0 0 snap:IndependentContinuant Definition: A continuant [snap:Continuant] that is a bearer of quality [snap:Quality] and realizable entity [snap:RealizableEntity] entities, in which other entities inhere and which itself cannot inhere in anything. Examples: an organism, a heart, a leg, a person, a symphony orchestra, a chair, the bottom right portion of a human torso, the lawn and atmosphere in front of our building Synonyms: substantial entity independent_continuant snap:MaterialEntity Definition: An independent continuant [snap:IndependentContinuant] that is spatially extended whose identity is independent of that of other entities and can be maintained through time. Note: Material entity [snap:MaterialEntity] subsumes object [snap:Object], fiat object part [snap:FiatObjectPart], and object aggregate [snap:ObjectAggregate], which assume a three level theory of granularity, which is inadequate for some domains, such as biology. Examples: collection of random bacteria, a chair, dorsal surface of the body material_entity 0 snap:Object Definition: A material entity [snap:MaterialEntity] that is spatially extended, maximally self-connected and self-contained (the parts of a substance are not separated from each other by spatial gaps) and possesses an internal unity. The identity of substantial object [snap:Object] entities is independent of that of other entities and can be maintained through time. Examples: an organism, a heart, a chair, a lung, an apple Synonyms: substance object snap:ObjectAggregate Definition: A material entity [snap:MaterialEntity] that is a mereological sum of separate object [snap:Object] entities and possesses non-connected boundaries. Examples: a heap of stones, a group of commuters on the subway, a collection of random bacteria, a flock of geese, the patients in a hospital Synonyms: substance aggregate object_aggregate snap:ObjectBoundary Comment: Boundaries are theoretically difficult entities to account for, however the intuitive notion of a physical boundary as a surface of some sort (whether inside or outside of a thing) will generally serve as a good guide for the use of this universal. Definition: An independent continuant [snap:IndependentContinuant] that is a lower dimensional part of a spatial entity, normally a closed two-dimensional surface. Boundaries are those privileged parts of object [snap:Object] entities that exist at exactly the point where the object [snap:Object] is separated off from the rest of the existing entities in the world. Examples: the surface of the skin, the surface of the earth, the surface of the interior of the stomach, the outer surface of a cell or cell wall Synonyms: substance boundary object_boundary snap:OneDimensionalRegion Definition: A spatial region [snap:SpatialRegion] with one dimension. Examples: the part of space that is a line stretching from one end of absolute space to the other, an edge of a cube-shaped part of space one_dimensional_region snap:Quality Definition: A specifically dependent continuant [snap:SpecificallyDependentContinuant] that is exhibited if it inheres in an entity or entities at all (a categorical property). Examples: the color of a tomato, the ambient temperature of air, the circumference of a waist, the shape of a nose, the mass of a piece of gold, the weight of a chimpanzee quality snap:RealizableEntity Comment: If a realizable entity [snap:RealizableEntity] inheres in a continuant [snap:Continuant], this does not imply that it is actually realized. Definition: A specifically dependent continuant [snap:SpecificallyDependentContinuant] that inheres in continuant [snap:Continuant] entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances. Examples: the role of being a doctor, the function of the reproductive organs, the disposition of blood to coagulate, the disposition of metal to conduct electricity realizable_entity snap:Role Definition: A realizable entity [snap:RealizableEntity] the manifestation of which brings about some result or end that is not essential to a continuant [snap:Continuant] in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant [snap:Continuant] in some kinds of natural, social or institutional contexts. Examples: the role of a person as a surgeon, the role of a chemical compound in an experiment, the role of a patient relative as defined by a hospital administrative form, the role of a woman as a legal mother in the context of system of laws, the role of a biological grandfather as legal guardian in the context of a system of laws, the role of ingested matter in digestion, the role of a student in a university role snap:Site Comment: An instance of Site [snap:Site] is a mixture of independent continuant [snap:IndependentContinuant] entities which act as surrounding environments for other independent continuant [snap:IndependentContinuant] entities, most importantly for instances of object [snap:Object]. A site [snap:Site] is typically made of object [snap:Object] or fiat object part [snap:FiatObjectPart] entities and a surrounding medium in which is found an object [snap:Object] occupying the site [snap:Site]. Independent continuant [snap:IndependentContinuant] entities may be associated with others (which, then, are site [snap:Site] entities) through a relation of "occupation". That relation is connected to, but distinct from, the relation of spatial location. Site [snap:Site] entities are not to be confused with spatial region [snap:SpatialRegion] entities. In BFO, site [snap:Site] allows for a so-called relational view of space which is different from the view corresponding to the class spatial region [snap:SpatialRegion] (see the comment on this class). Definition: An independent continuant [snap:IndependentContinuant] consisting of a characteristic spatial shape in relation to some arrangement of other continuant [snap:Continuant] entities and of the medium which is enclosed in whole or in part by this characteristic spatial shape. Site [snap:Site] entities are entities that can be occupied by other continuant [snap:Continuant] entities. Examples: a particular room in a particular hospital, Maria's nostril or her intestines for a variety of bacteria. site 0 snap:SpatialRegion Comment: All instances of continuant [snap:Continuant] are spatial entities, that is, they enter in the relation of (spatial) location with spatial region [snap:SpatialRegion] entities. As a particular case, the exact spatial location of a spatial region [snap:SpatialRegion] is this region itself. Comment: An instance of spatial region [snap:SpatialRegion] is a part of space. All parts of space are spatial region [snap:SpatialRegion] entities and only spatial region [snap:SpatialRegion] entities are parts of space. Space is the entire extent of the spatial universe, a designated individual, which is thus itself a spatial region [snap:SpatialRegion]. Comment: Space and spatial region [snap:SpatialRegion] entities are entities in their own rights which exist independently of any entities which can be located at them. This view of space is sometimes called "absolutist" or "the container view". In BFO, the class site [snap:Site] allows for a so-called relational view of space, that is to say, a view according to which spatiality is a matter of relative location between entities and not a matter of being tied to space. The bridge between these two views is secured through the fact that while instances of site [snap:Site] are not spatial region [snap:SpatialRegion] entities, they are nevertheless spatial entities. Definition: A continuant [snap:Continuant] that is neither bearer of quality [snap:Quality] entities nor inheres in any other entities. Examples: the sum total of all space in the universe, parts of the sum total of all space in the universe spatial_region snap:SpecificallyDependentContinuant Definition: A continuant [snap:Continuant] that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same. Examples: the mass of a cloud, the smell of mozzarella, the liquidity of blood, the color of a tomato, the disposition of fish to decay, the role of being a doctor, the function of the heart in the body: to pump blood, to receive de-oxygenated and oxygenated blood, etc. Synonyms: property, trope, mode specifically_dependent_continuant snap:ThreeDimensionalRegion Definition: A spatial region [snap:SpatialRegion] with three dimensions. Examples: a cube-shaped part of space, a sphere-shaped part of space three_dimensional_region snap:TwoDimensionalRegion Definition: A spatial region [snap:SpatialRegion] with two dimensions. Examples: the surface of a cube-shaped part of space, the surface of a sphere-shaped part of space, the surface of a rectilinear planar figure-shaped part of space two_dimensional_region snap:ZeroDimensionalRegion Definition: A spatial region [snap:SpatialRegion] with no dimensions. Examples: a point zero_dimensional_region span:ConnectedSpatiotemporalRegion Definition: A spatiotemporal region [span:SpatiotemporalRegion] that has temporal and spatial dimensions such that all points within the spatiotemporal region are mediately or immediately connected to all other points within the same spatiotemporal region [span:SpatiotemporalRegion]. Examples: the spatial and temporal location of an individual organism's life, the spatial and temporal location of the development of a fetus connected_spatiotemporal_region span:ConnectedTemporalRegion Definition: A temporal region [span:TemporalRegion] every point of which is mediately or immediately connected with every other point of which. Examples: the 1970s years, the time from the beginning to the end of a heart attack, the time taken up by cellular meiosis connected_temporal_region 0 0 0 span:FiatProcessPart Definition: A processual entity [span:ProcessualEntity] that is part of a process but that does not have bona fide beginnings and endings corresponding to real discontinuities. Examples: chewing during a meal, the middle part of a rainstorm, the worst part of a heart-attack, the most interesting part of Van Gogh's life fiat_process_part 0 span:Occurrent Definition: An entity [bfo:Entity] that has temporal parts and that happens, unfolds or develops through time. Sometimes also called perdurants. Examples: the life of an organism, a surgical operation as processual context for a nosocomical infection, the spatiotemporal context occupied by a process of cellular meiosis, the most interesting part of Van Gogh's life, the spatiotemporal region occupied by the development of a cancer tumor Synonyms: perdurant occurrent 0 0 0 0 0 1 1 0 span:Process Definition: A processual entity [span:ProcessualEntity] that is a maximally connected spatiotemporal whole and has bona fide beginnings and endings corresponding to real discontinuities. Examples: the life of an organism, the process of sleeping, the process of cell-division process 0 0 0 span:ProcessAggregate Definition: A processual entity [span:ProcessualEntity] that is a mereological sum of process [span:Process] entities and possesses non-connected boundaries. Examples: the beating of the hearts of each of seven individuals in the room, the playing of each of the members of an orchestra, a process of digestion and a process of thinking taken together process_aggregate 1 span:ProcessBoundary Definition: A processual entity [span:ProcessualEntity] that is the fiat or bona fide instantaneous temporal process boundary. Examples: birth, death, the forming of a synapse, the onset of REM sleep, the detaching of a finger in an industrial accident, the final separation of two cells at the end of cell-division, the incision at the beginning of a surgery process_boundary span:ProcessualContext Comment: An instance of a processual context [span:ProcessualContext] is a mixture of processual entity [span:ProcessualEntity] which stand as surrounding environments for other processual entity [span:ProcessualEntity] entities. The class processual context [span:ProcessualContext] is the analogous among occurrent [span:Occurrent] entities to the class site [snap:Site] among continuant [snap:Continuant] entities. Definition: An occurrent [span:Occurrent] consisting of a characteristic spatial shape inhering in some arrangement of other occurrent [span:Occurrent] entities. Processual context [span:ProcessualContext] entities are characteristically entities at or in which other occurrent [span:Occurrent] entities can be located or occur. Examples: The processual context for a given manipulation occurring as part of an experiment is made of processual entities which occur in parallel, are not necessarily all parts of the experiment themselves and may involve continuant [snap:Continuant] entities which are in the spatial vicinity of the participants in the experiment. processual_context span:ProcessualEntity Definition: An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity. Examples: the life of an organism, the process of meiosis, the course of a disease, the flight of a bird processual_entity span:ScatteredSpatiotemporalRegion Definition: A spatiotemporal region [span:SpatiotemporalRegion] that has spatial and temporal dimensions and every spatial and temporal point of which is not connected with every other spatial and temporal point of which. Examples: the space and time occupied by the individual games of the World Cup, the space and time occupied by the individual liaisons in a romantic affair scattered_spatiotemporal_region span:ScatteredTemporalRegion Definition: A temporal region [span:TemporalRegion] every point of which is not mediately or immediately connected with every other point of which. Examples: the time occupied by the individual games of the World Cup, the time occupied by the individual liaisons in a romantic affair scattered_temporal_region span:SpatiotemporalInstant Definition: A connected spatiotemporal region [span:ConnectedSpatiotemporalRegion] at a specific moment. Examples: the spatiotemporal region occupied by a single instantaneous temporal slice (part) of a process spatiotemporal_instant span:SpatiotemporalInterval Definition: A connected spatiotemporal region [span:ConnectedSpatiotemporalRegion] that endures for more than a single moment of time. Examples: the spatiotemporal region occupied by a process or by a fiat processual part spatiotemporal_interval span:SpatiotemporalRegion Comment: All instances of occurrent [span:Occurrent] are spatiotemporal entities, that is, they enter in the relation of (spatiotemporal) location with spatiotemporal region [span:SpatiotemporalRegion] entities. As a particular case, the exact spatiotemporal location of a spatiotemporal region [span:SpatiotemporalRegion] is this region itself. Comment: An instance of the spatiotemporal region [span:SpatiotemporalRegion] is a part of spacetime. All parts of spacetime are spatiotemporal region [span:SpatiotemporalRegion] entities and only spatiotemporal region [span:SpatiotemporalRegion] entities are parts of spacetime. In particular, neither spatial region [snap:SpatialRegion] entities nor temporal region [span:TemporalRegion] entities are in BFO parts of spacetime. Spacetime is the entire extent of the spatiotemporal universe, a designated individual, which is thus itself a spatiotemporal region [span:SpatiotemporalRegion]. Spacetime is among occurrents the analogous of space among continuant [snap:Continuant] entities. Comment: Spacetime and spatiotemporal region [span:SpatiotemporalRegion] entities are entities in their own rights which exist independently of any entities which can be located at them. This view of spacetime can be called "absolutist" or "the container view". In BFO, the class processual context [span:ProcessualContext] allows for a so-called relational view of spacetime, that is to say, a view according to which spatiotemporality is a matter of relative location between entities and not a matter of being tied to spacetime. In BFO, the bridge between these two views is secured through the fact that instances of processual context [span:ProcessualContext] are too spatiotemporal entities. Definition: An occurrent [span:Occurrent] at or in which processual entity [span:ProcessualEntity] entities can be located. Examples: the spatiotemporal region occupied by a human life, the spatiotemporal region occupied by the development of a cancer tumor, the spatiotemporal context occupied by a process of cellular meiosis spatiotemporal_region span:TemporalInstant Definition: A connected temporal region [span:ConnectedTemporalRegion] comprising a single moment of time. Examples: right now, the moment at which a finger is detached in an industrial accident, the moment at which a child is born, the moment of death temporal_instant span:TemporalInterval Definition: A connected temporal region [span:ConnectedTemporalRegion] lasting for more than a single moment of time. Examples: any continuous temporal duration during which a process occurs temporal_interval span:TemporalRegion Comment: All instances of occurrent [span:Occurrent] are temporal entities, that is, they enter in the relation of (temporal) location with temporal region [span:TemporalRegion] entities. As a particular case, the exact spatiotemporal location of a temporal region [span:TemporalRegion] is this region itself. Continuant [snap:Continuant] entities are not temporal entities in the technical sense just explained; they are related to time in a different way, not through temporal location but through a relation of existence at a time or during a period of time (see continuant [snap:Continuant]. Comment: An instance of temporal region [span:TemporalRegion] is a part of time. All parts of time are temporal region [span:TemporalRegion] entities and only temporal region [span:TemporalRegion] entities are parts of time. Time is the entire extent of the temporal universe, a designated individual, which is thus a temporal region itself. Comment: Time and temporal region [span:TemporalRegion] entities are entities in their own rights which exist independently of any entities which can be located at them. This view of time can be called "absolutist" or "the container view" in analogy to what is traditionally the case with space (see spatial region [snap:SpatialRegion]. Definition: An occurrent [span:Occurrent] that is part of time. Examples: the time it takes to run a marathon, the duration of a surgical procedure, the moment of death temporal_region owl:Thing European Rhabdoid Study http://www.heratrial.com/ definition: Tumor confined to kidney and completely resected definition: Microscopic residual tumor, tumor penetration through renal capsule definition: Gross residual disease confined to abdomen, lymph node involvement, diffuse peritoneal contamination (tumor rupture) definition: Hematogenous Metastases: lung, noncontiguous liver, bone, and brain definition: Bilateral renal involvement at diagnosis Cristian Cocos Holger Stenzhorn Mathias Brochhausen Sarah Lerch Ulf Schwarz Insitute for Formal Ontology and Medical Information Science (IFOMIS) ACGT Master Ontology acgt:BRGrade1 acgt:BRGrade2 acgt:BRGrade3 acgt:FuhrmanGradeI acgt:FuhrmanGradeII acgt:FuhrmanGradeIII acgt:FuhrmanGradeIV acgt:Functional acgt:G1 Well-differentiated (Low grade) acgt:G2 Moderately differentiated (Intermediate grade) acgt:G3 Poorly differentiated (High grade) acgt:G4 Undifferentiated (High grade); undifferentiated = a term used to describe cells or tissues that do not have specialized ("mature") structures or functions. Undifferentiated cancer cells often grow and spread quickly. acgt:GX Grade cannot be assessed (Undetermined grade) acgt:Left acgt:Right acgt:Structural Alan Ruttenberg Andrew Spear Pierre Grenon Holger Stenzhorn application/rdf+xml http://www.ifomis.org/bfo/1.1 en Institute for Formal Ontology and Medical Information Science (IFOMIS) http://creativecommons.org/licenses/by/3.0 Barry Smith and Pierre Grenon: "The Cornucopia of Formal Ontological Relations" Barry Smith: "Against Fantology" Barry Smith: "Basic Tools of Formal Ontology" Barry Smith: "Beyond Concepts: Ontology as Reality Representation" Pierre Grenon and Barry Smith: "SNAP and SPAN: Towards Geospatial Dynamics" Pierre Grenon, Barry Smith and Louis Goldberg: "Biodynamic Ontology: Applying BFO in the Biomedical Domain" Pierre Grenon: "BFO in a Nutshell: A Bi-categorial Axiomatization of BFO and Comparison with DOLCE" Pierre Grenon: "Nuts in BFO's Nutshell: Revisions to the Bi-categorial Axiomatization of BFO" Pierre Grenon: "Spatio-temporality in Basic Formal Ontology: SNAP and SPAN, Upper-Level Ontology, and Framework for Formalization" Basic Formal Ontology (BFO) 1.1.1 Chris Mungall Holger Stenzhorn Stefan Schulz 2007-11-29 Barry Smith, Werner Ceusters, Bert Klagges, Jacob Koehler, Anand Kumar, Jane Lomax, Chris Mungall, Fabian Neuhaus, Alan Rector and Cornelius Rosse: "Relations in Biomedical Ontologies" Relationship Ontology (RO) 1.0 As for hasParticipant, but with the additional condition that the component instance is causally active in the relevant process has_agent has_part HasParticipant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane hasParticipant this particular sample of hemoglobin at this particular time. has_participant has_proper_part The primitive instance-level relation c locatedIn r at t reflects the fact that each continuant is at any given time associated with exactly one spatial region, namely its exact location. Following we can use this relation to define a further instance-level location relation - not between a continuant and the region which it exactly occupies, but rather between one continuant and another. c is located in c1, in this sense, whenever the spatial region occupied by c is partOf the spatial region occupied by c1. Note that this relation comprehends both the relation of exact location between one continuant and another which obtains when r and r1 are identical (for example, when a portion of fluid exactly fills a cavity), as well as those sorts of inexact location relations which obtain, for example, between brain and head or between ovum and uterus located_in The primitive instance-level relation p partOf p1 is illustrated in assertions such as: this instance of rhodopsin mediated phototransduction partOf this instance of visual perception. This relation satisfies at least the following standard axioms of mereology: reflexivity (for all p, p partOf p); anti-symmetry (for all p, p1, if p partOf p1 and p1 partOf p then p and p1 are identical); and transitivity (for all p, p1, p2, if p partOf p1 and p1 partOf p2, then p partOf p2). Analogous axioms hold also for parthood as a relation between spatial regions. For parthood as a relation between continuants, these axioms need to be modified to take account of the incorporation of a temporal argument. Thus for example the axiom of transitivity for continuants will assert that if c partOf c1 at t and c1 partOf c2 at t, then also c partOf c2 at t. part_of participates_in p precededBy p' if and only if: given any process p at a time t, there is some process p' at time t', and t' is earlier than t. preceded_by precedes As for partOf, with the additional constraint that subject and object are distinct proper_part_of