Alzheimer Disease Relevance Ontology by Process AD-DROP part of Lancet score frequency score pathogenic intensity level specificity level AD-DROP:AlzheimerDiseaseTypedisease-relevantProcess 'identified disease-relevant process'(?x), 'specificity level'(?x, ?SL), equal(?SL, 6) -> 'Alzheimer Disease type disease-relevant process'(?x) Process that appears relevant for Alzheimer disease (AD) with a value equal to 6 the specificity toward AD Alzheimer Disease type disease-relevant process Alzheimer Disease type DRP AD-DROP:AlzheimerDiseasedisease-relevantProcess 'identified disease-relevant process'(?x), 'specificity level'(?x, ?SL), equal(?SL, 5) -> 'Alzheimer Disease disease-relevant process'(?x) Process that appears relevant for Alzheimer disease (AD) with a value equal to 5 the specificity toward AD Alzheimer Disease disease-relevant process Alzheimer Disease DRP AD-DROP:classifieddisease-relevantProcessByProperties Upper class of a branch where DRPs are classified through their properties of specificity, frequency and/or pathogenic intensity toward Alzheimer disease. No DRPs should be asserted in this branch, they will be classified according logical reasoning. Process that appears relevant for Alzheimer disease (AD) with at least one value for one of the specificity, frequency or pathogenic intensity toward AD classified disease-relevant process by properties classified DRP by properties AD-DROP:communlyFrequentdisease-relevantProcess 'identified disease-relevant process'(?x), 'frequency score'(?x, ?FS), greaterThanOrEqual(?FS, 25), lessThan(?FS, 50) -> 'communly frequent disease-relevant process'(?x) Process that appears relevant for Alzheimer disease (AD) with a value between 25 and 49% for its frequency toward AD communly frequent disease-relevant process Communly frequent DRP AD-DROP:disease-relevantProcessByFrequency DRP by pathogenic intensity is the upper class of 4 classes wich represente 4 levels of frequency on a scale from occasional DRP to very frequent DRP. These levels depend to the DRP value (occasional [1-24%], commun [25-49%], frequent [50-74%] and very frequent [75-100]) Process that appears relevant for Alzheimer disease (AD) with one value for frequency toward AD disease-relevant process by Frequency DRP by Frequency AD-DROP:disease-relevantProcessByPathogenicIntensity DRP by pathogenic intensity is the upper class of 3 classes wich represente 3 levels of pathogenic intensity on a scale from lowly intense DRP to highly DRP. These levels depend to the DRP value (low [1-3], middle [4-7], high [8-] according lancet score (Lancet's “population attributable fraction” attributed to this DRP (p. 428, Livingston et al., 2020))) Process that appears relevant for Alzheimer disease (AD) with at least one value for pathogenic intensity toward AD disease-relevant process by pathogenic intensity DRP by pathogenic intensity AD-DROP:disease-relevantProcessBySpecificity DRP by specificity is the upper class of 7 classes wich represente 7 levels of specificities on a scale from individual DRP to life-style DRP. These levels depend to the DRP value. Process that appears relevant for Alzheimer disease (AD) with one value for one of the specificity toward AD disease-relevant process by specificity DRP by specificity AD-DROP:environmentaldisease-relevantProcess DRP identified as belonging to environmental level. environmental disease-relevant process environmental DRP AD-DROP:frequentdisease-relevantProcess 'identified disease-relevant process'(?x), 'frequency score'(?x, ?FS), greaterThanOrEqual(?FS, 50), lessThan(?FS, 75) -> 'frequent disease-relevant process'(?x) Process that appears relevant for Alzheimer disease (AD) with a value between 50 and 74% for its frequency toward AD frequent disease-relevant process Frequent DRP AD-DROP:gene-relateddisease-relevantProcess DRP identified as belonging to gene level. gene-related disease-relevant process gene-related DRP AD-DROP:highlyImpactingdisease-relevantProcess 'identified disease-relevant process'(?x), 'pathogenic intensity level'(?x, ?PIL), greaterThan(?PIL, 7) -> 'highly impacting disease-relevant process'(?x) Process that appears relevant for Alzheimer disease (AD) with a value greater than 8 to its intensity toward AD highly impacting disease-relevant process highly impacting DRP AD-DROP:identifieddisease-relevantProcess Upper class of a branch where DRPs are classified through their traditionnal biological level (gene-related, molecular, physiological…). Any DRPs should be asserted in this branch. Process that appears relevant for Alzheimer disease. identified disease-relevant process identified DRP AD-DROP:individualdisease-relevantProcess 'identified disease-relevant process'(?x), 'specificity level'(?x, ?SL), equal(?SL, 7) -> 'individual disease-relevant process'(?x) Process that appears relevant for Alzheimer disease (AD) with a value equal to 7 the specificity toward AD individual disease-relevant process individual DRP AD-DROP:life-styledisease-relevantProcess 'identified disease-relevant process'(?x), 'specificity level'(?x, ?SL), equal(?SL, 2) -> 'life-style disease-relevant process'(?x) Process that appears relevant for Alzheimer disease (AD) with a value equal to 2 the specificity toward AD life-style disease-relevant process life-style DRP AD-DROP:lifedisease-relevantProcess 'identified disease-relevant process'(?x), 'specificity level'(?x, ?SL), equal(?SL, 1) -> 'life disease-relevant process'(?x) Process that appears relevant for Alzheimer disease (AD) with a value equal to 1 the specificity toward AD life disease-relevant process life DRP AD-DROP:lowlyImpactingdisease-relevantProcess 'identified disease-relevant process'(?x), 'pathogenic intensity level'(?x, ?PIL), greaterThanOrEqual(?PIL, 1), lessThan(?PIL, 3) -> 'lowly impacting disease-relevant process'(?x) Process that appears relevant for Alzheimer disease (AD) with a value between 4 and 7 for its the pathogenic intensity toward AD lowly impacting disease-relevant process lowly impacting DRP AD-DROP:midlyImpactingdisease-relevantProcess 'identified disease-relevant process'(?x), 'pathogenic intensity level'(?x, ?PIL), greaterThanOrEqual(?PIL, 4), lessThan(?PIL, 8) -> 'midly impacting disease-relevant process'(?x) Process that appears relevant for Alzheimer disease (AD) with a value between 1 and 3 for its the pathogenic intensity toward AD midly impacting disease-relevant process midly impacting DRP AD-DROP:moleculardisease-relevantProcess DRP identified as belonging to molecular level. molecular disease-relevant process Molecular DRP AD-DROP:neurodegenerativeDiseasedisease-relevantProcess 'identified disease-relevant process'(?x), 'specificity level'(?x, ?SL), equal(?SL, 4) -> 'neurodegenerative disease disease-relevant process'(?x) Process that appears relevant for Alzheimer disease (AD) with a value equal to 4 the specificity toward AD neurodegenerative disease disease-relevant process neurodegenerative disease DRP AD-DROP:occasionaldisease-relevantProcess 'identified disease-relevant process'(?x), 'frequency score'(?x, ?FS), greaterThanOrEqual(?FS, 1), lessThan(?FS, 25) -> 'occasional disease-relevant process'(?x) Process that appears relevant for Alzheimer disease (AD) with a value between 1 and 24% for its frequency toward AD occasional disease-relevant process Occasional DRP AD-DROP:otherdisease-relevantProcess Identified DRP that do not refer to any discribed biological level. other disease-relevant process Other DRP AD-DROP:pathogenicdisease-relevantProcess 'identified disease-relevant process'(?x), 'specificity level'(?x, ?SL), equal(?SL, 3) -> 'pathogenic disease-relevant process'(?x) Process that appears relevant for Alzheimer disease (AD) with a value equal to 3 the specificity toward AD pathogenic disease-relevant process pathogenic DRP AD-DROP:pathologicaldisease-relevantProcess DRP identified as belonging to pathological level. pathological disease-relevant process Pathological DRP AD-DROP:physiologicaldisease-relevantProcess DRP identified as belonging to physiological level. physiological disease-relevant process Physiological DRP AD-DROP:veryFrequentdisease-relevantProcess 'identified disease-relevant process'(?x), 'frequency score'(?x, ?FS), greaterThanOrEqual(?FS, 75) -> 'very frequent disease-relevant process'(?x) Process that appears relevant for Alzheimer disease (AD) with a value between 75 and 100% for its frequency toward AD very frequent disease-relevant process Very frequent DRP 6 A-Beta deposition 6 A-Beta oligomers 6 A-Beta prion-like mechanisms 7 ABCA7 7 APOE 7 APP 5 Amyloid impairment 7 BIN1 7 CD33 7 CLU 4 CNS glucose metabolism imbalance 7 CR1 3 Calcium pathway dysregulation 3 Cell death 3 Cellular imbalances 3 DNA damage 3 Genetic imbalances 3 Herpes infection 3 Inflammation 3 Lysosomes dyfunction 3 Molecular imbalances 4 Network failure 4 Neuronal cell cycle 7 PSEN1 7 PSEN2 7 SORL1 4 Synaptic loss 5 Tau deposition 6 Tau hyperphosphorylation 5 Tau imperment 6 Tau oligomers 1 aging 2 2 air pollution 1 2 alcohol 3 bioenergetics dysfunction 4 brain atrophy 4 brain hypometabolism 4 cerebrovascular dysfunction 3 chronic sleep disorder 6 dementia 4 2 depression 1 3 diabetes 4 excitotoxicity 2 gender 8 2 hearing loss 2 2 hypertension 7 2 less education 5 memory impairment 3 mitochondira dysfunction 4 neuroinflammation 4 neuronal loss 2 nutrition 1 2 obesity 3 oxidative stress 2 2 physical inactivity 3 proteasome dysfunction 3 reduced autophagy 5 2 smoking 4 2 social isolation 4 synaptic dysfunction 3 2 traumatic brain injury 3 weaker microtubules Alzheimer Disease Relevance Ontology by Process AD-DROP 1 25 2 3 4 5 6 25 50 7 50 75 75 7 1 3 4 8 1