cv2obo 29:05:2025 10:16 antibiotic_resistance 1.2 CARD definition database_cross_reference has_exact_synonym has_obo_format_version has_obo_namespace has_synonym_type shorthand BFO:0000050 antibiotic_resistance part_of part_of part_of RO:is_a antibiotic_resistance is_a is_a is_a Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins. antibiotic_resistance ARO:0000000 macrolide antibiotic ARO:0000000 Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins. PMID:11324679 PMID:15544496 PMID:27480866 The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death. fluoroquinolone quinolone antibiotic_resistance ARO:0000001 fluoroquinolone antibiotic ARO:0000001 The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death. PMID:23010009 PMID:3311572 PMID:3802748 A family of proteins known to bind to the 30S ribosomal subunit. This interaction prevents tetracycline and tetracycline derivatives from inhibiting ribosomal function. Thus, these proteins confer elevated resistance to tetracycline derivatives as a ribosomal protection protein. antibiotic_resistance ARO:0000002 tetracycline-resistant ribosomal protection protein ARO:0000002 Astromicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Astromicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. CAS:55779-06-1 ChEBI:37923 ChEMBL:CHEMBL3084803 PubChem:5284517 Astromicina Astromicine Astromicinum fortimicin A antibiotic_resistance ARO:0000003 astromicin ARO:0000003 Astromicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Astromicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. PMID:10103173 PMID:11083623 PMID:8385262 Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. antibiotic_resistance ARO:0000004 monobactam ARO:0000004 Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. PMID:02669628 PMID:11585791 PMID:15673804 PMID:3871589 Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. CAS:1404-04-2 ChEBI:7507 ChEMBL:CHEMBL3989751 PubChem:8378 Fradiomycin Fradiomycinum Framycetinum Mycifradin Neomas Soframycin framycetin neomycin B antibiotic_resistance ARO:0000005 neomycin ARO:0000005 Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. PMID:10103173 PMID:11083623 PMID:8385262 Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited. ChEBI:48923 ChEMBL:CHEMBL532 PubChem:12560 Abomacetin Emgel Eritromicina Erymax Erythrocin Erythromycin A Erythromycine Erythromycinum N-methylerythromycin A antibiotic_resistance ARO:0000006 erythromycin ARO:0000006 Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited. PMID:10582867 PMID:15980346 PMID:7683018 Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. CAS:34493-98-6 ChEBI:37945 ChEMBL:CHEMBL560976 PubChem:470999 Debecacin Dibekacina Dibekacine Dibekacinum Dideoxykanamycin B Icacine Kappati Orbicin Panamicin antibiotic_resistance ARO:0000007 dibekacin ARO:0000007 Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. PMID:10103173 PMID:11083623 PMID:8385262 Cefoxitin is a cephamycin antibiotic often grouped with the second generation cephalosporins. Cefoxitin is bactericidal and acts by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. Cefoxitin's 7-alpha-methoxy group and 3' leaving group make it a poor substrate for most beta-lactamases. CAS:35607-66-0 ChEBI:209807 ChEMBL:CHEMBL996 PubChem:441199 FOX Mefoxitin mefoxin antibiotic_resistance ARO:0000008 cefoxitin ARO:0000008 Cefoxitin is a cephamycin antibiotic often grouped with the second generation cephalosporins. Cefoxitin is bactericidal and acts by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. Cefoxitin's 7-alpha-methoxy group and 3' leaving group make it a poor substrate for most beta-lactamases. PMID:11585791 PMID:15673804 PMID:3487346 Tunicamycin is mixture of homologous nucleoside antibiotics that block the reaction of UDP-N-acetylglucosamine and dolichyl phosphate in the first step of glycoprotein synthesis. CAS:11089-65-9 ChEBI:29699 ChEMBL:CHEMBL505513 PubChem:5354023 antibiotic_resistance ARO:0000009 tunicamycin ARO:0000009 Tunicamycin is mixture of homologous nucleoside antibiotics that block the reaction of UDP-N-acetylglucosamine and dolichyl phosphate in the first step of glycoprotein synthesis. PMID:1624425 Clusters of antibiotic resistance genes. May be regulated by a shared promoter or repressor. antibiotic_resistance ARO:0000010 antibiotic resistance gene cluster, cassette, or operon ARO:0000010 Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. CAS:61-72-3 ChEBI:49566 ChEMBL:CHEMBL891 PubChem:6098 Chloroxacillin Clossacillina Cloxacilina Cloxacilline Cloxacillinum Cloxapen Methocillin S Orbenin Syntarpen Tegopen antibiotic_resistance ARO:0000011 cloxacillin ARO:0000011 Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. PMID:11585791 PMID:1234495 PMID:15673804 Streptothricins are a group of N-glycoside antibiotics that include a carbamoylated D-glucosamine to which are attached a series of L-beta-lysine residues at position 2 and a streptolidine at position 1. Streptothricins vary by the number of beta-lysine residues (from 1 (nourseothricin) to 7) and target protein synthesis in bacteria and eukaryotes. CAS:3808-42-2 ChEBI:60821 ChEMBL:CHEMBL1801945 PubChem:475825 nourseothricin racemomycin streptothricin F yazumycin antibiotic_resistance ARO:0000012 streptothricin ARO:0000012 Streptothricins are a group of N-glycoside antibiotics that include a carbamoylated D-glucosamine to which are attached a series of L-beta-lysine residues at position 2 and a streptolidine at position 1. Streptothricins vary by the number of beta-lysine residues (from 1 (nourseothricin) to 7) and target protein synthesis in bacteria and eukaryotes. PMID:10103173 PMID:11083623 PMID:8385262 Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. CAS:37517-28-5 ChEBI:2637 ChEMBL:CHEMBL177 PubChem:37768 AMK Amicacin Amikacina Amikacinum Amikavet Arikace Kaminax Lukadin Mikavir amikacine mikacin antibiotic_resistance ARO:0000013 amikacin ARO:0000013 Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. PMID:10103173 PMID:11083623 PMID:8385262 Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. CAS:11097-82-8 ChEBI:75616 ChEMBL:CHEMBL384124 PubChem:3084091 Cidomycin Garamycin Gentacycol Gentamicins Gentamycinum Gentavet Gentocin Refobacin Uromycine antibiotic_resistance ARO:0000014 gentamicin C ARO:0000014 Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. PMID:10103173 PMID:11083623 PMID:8385262 Derived from penicillin to combat penicillin-resistance, methicillin is insensitive to beta-lactamases (also known as penicillinases) secreted by many penicillin-resistant bacteria. Methicillin is bactericidal, and acts by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. CAS:61-32-5 ChEBI:6827 ChEMBL:CHEMBL575 PubChem:6087 Dimocillin Metacillin Methicillinum Methycillin Meticilina Meticilline Meticillinum Staphcillin meticillin antibiotic_resistance ARO:0000015 methicillin ARO:0000015 Derived from penicillin to combat penicillin-resistance, methicillin is insensitive to beta-lactamases (also known as penicillinases) secreted by many penicillin-resistant bacteria. Methicillin is bactericidal, and acts by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. PMID:11585791 PMID:15673804 PMID:3889939 Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth. antibiotic_resistance ARO:0000016 aminoglycoside antibiotic ARO:0000016 Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth. PMID:10103173 PMID:11083623 PMID:8385262 Lincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides. lincosamide antibiotic_resistance ARO:0000017 lincosamide antibiotic ARO:0000017 Lincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides. PMID:10582867 PMID:15135500 Viomycin sulfate (Viocin) is an polypeptide antibiotic used in the treatment of tuberculosis. It is produced by the actinomycete Streptomyces puniceus and binds to the bacterial ribosome, inhibiting prokaryotic protein synthesis and certain forms of RNA splicing. PubChem:135398671 Celiomycin Florimycin Tuberactinomycin B Viocin antibiotic_resistance ARO:0000018 viomycin ARO:0000018 Viomycin sulfate (Viocin) is an polypeptide antibiotic used in the treatment of tuberculosis. It is produced by the actinomycete Streptomyces puniceus and binds to the bacterial ribosome, inhibiting prokaryotic protein synthesis and certain forms of RNA splicing. PMID:211438 Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. antibiotic_resistance ARO:0000020 carbapenem ARO:0000020 Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. PMID:11585791 PMID:15673804 Ribostamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Ribostamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. CAS:25546-65-0 ChEBI:45257 ChEMBL:CHEMBL221572 PubChem:33042 dekamycin IV hetangmycin ribastamin vistamycin xylostatin antibiotic_resistance ARO:0000021 ribostamycin ARO:0000021 Ribostamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Ribostamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. PMID:10103173 PMID:11083623 PMID:8385262 Polymyxins are cationic detergent antibiotics, with a general structure of a cyclic peptide with a long hydrophobic tail. They disrupt the structure of the bacterial cell membrane by interacting with its phospholipids. Polymyxins have a bactericidal effect on Gram-negative bacilli, especially on Pseudomonas and coliform organisms. antibiotic_resistance ARO:0000022 polymyxin antibiotic ARO:0000022 Polymyxins are cationic detergent antibiotics, with a general structure of a cyclic peptide with a long hydrophobic tail. They disrupt the structure of the bacterial cell membrane by interacting with its phospholipids. Polymyxins have a bactericidal effect on Gram-negative bacilli, especially on Pseudomonas and coliform organisms. PMID:11706007 Enoxacin belongs to a group called fluoroquinolones. Its mode of action depends upon blocking bacterial DNA replication by binding itself to DNA gyrase and causing double-stranded breaks in the bacterial chromosome. CAS:74011-58-8 ChEBI:157175 ChEMBL:CHEMBL826 PubChem:3229 Enroxil Penetrex antibiotic_resistance ARO:0000023 enoxacin ARO:0000023 Enoxacin belongs to a group called fluoroquinolones. Its mode of action depends upon blocking bacterial DNA replication by binding itself to DNA gyrase and causing double-stranded breaks in the bacterial chromosome. PMID:15914491 Butirosin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Butirosin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. CAS:12772-35-9 ChEBI:65109 ChEMBL:CHEMBL3549904 PubChem:72393 ambutyrosin sulfate butirosin sulphate antibiotic_resistance ARO:0000024 butirosin ARO:0000024 Butirosin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Butirosin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. PMID:10103173 PMID:11083623 PMID:8385262 Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction. CAS:23155-02-4 ChEBI:28915 ChEMBL:CHEMBL1757 PubChem:73491 (1R,2S)-1,2-epoxy-propylphosphonic acid phosphomycin phosphonomycin antibiotic_resistance ARO:0000025 fosfomycin ARO:0000025 Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction. PMID:17567049 PMID:18701452 PMID:5809587 PMID:8075064 PMID:8994972 Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30. antibiotic_resistance ARO:0000026 streptogramin antibiotic ARO:0000026 Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30. PMID:15700955 Roxithromycin is a semi-synthetic, 14-carbon ring macrolide antibiotic derived from erythromycin. It is used to treat respiratory tract, urinary and soft tissue infections. Roxithromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited. ChEBI:48844 ChEMBL:CHEMBL1214185 PubChem:6915744 antibiotic_resistance ARO:0000027 roxithromycin ARO:0000027 Roxithromycin is a semi-synthetic, 14-carbon ring macrolide antibiotic derived from erythromycin. It is used to treat respiratory tract, urinary and soft tissue infections. Roxithromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited. PMID:10582867 PMID:15980346 Vancomycin is a glycopeptide antibiotic used in the prophylaxis and treatment of infections caused by Gram-positive bacteria. Vancomycin inhibits the synthesis of peptidoglycan, the major component of the cell wall of gram-positive bacteria. Its mechanism of action is unusual in that it acts by binding precursors of peptidoglycan, rather than by interacting with an enzyme. ChEBI:28001 ChEMBL:CHEMBL262777 PubChem:14969 Vancocin antibiotic_resistance ARO:0000028 vancomycin ARO:0000028 Vancomycin is a glycopeptide antibiotic used in the prophylaxis and treatment of infections caused by Gram-positive bacteria. Vancomycin inhibits the synthesis of peptidoglycan, the major component of the cell wall of gram-positive bacteria. Its mechanism of action is unusual in that it acts by binding precursors of peptidoglycan, rather than by interacting with an enzyme. PMID:16323116 Teicoplanin is a glycopeptide antibiotic used in the prophylaxis and treatment of serious infections caused by Gram-positive bacteria. Teicoplanin has a unique acyl-aliphatic chain, and binds to cell wall precursors to inhibit transglycosylation and transpeptidation. CAS:61036-62-2 ChEBI:29687 ChEMBL:CHEMBL2367892 PubChem:16129712 targocid teichomycin antibiotic_resistance ARO:0000029 teicoplanin ARO:0000029 Teicoplanin is a glycopeptide antibiotic used in the prophylaxis and treatment of serious infections caused by Gram-positive bacteria. Teicoplanin has a unique acyl-aliphatic chain, and binds to cell wall precursors to inhibit transglycosylation and transpeptidation. PMID:11131961 PMID:16323116 PMID:6235205 PMID:6239854 PMID:6240963 Tigecycline is an glycylcycline antibiotic. It works by inhibiting action of the prokaryotic 30S ribosome. CAS:220620-09-7 ChEBI:149836 ChEMBL:CHEMBL376140 PubChem:54686904 Tygacil antibiotic_resistance ARO:0000030 tigecycline ARO:0000030 Tigecycline is an glycylcycline antibiotic. It works by inhibiting action of the prokaryotic 30S ribosome. PMID:11381101 PMID:19862477 Resistance to antibiotics is often conferred by single nucleotide polymorphisms (SNPs) and other mutations in target genes. antibiotic_resistance ARO:0000031 antibiotic resistant gene variant or mutant ARO:0000031 Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. antibiotic_resistance ARO:0000032 cephalosporin ARO:0000032 Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. PMID:11585791 PMID:15673804 PMID:6810737 Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. antibiotic_resistance ARO:0000034 streptogramin A antibiotic ARO:0000034 Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. PMID:12102603 PMID:12860128 PMID:15700955 PMID:17015629 Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. CAS:32385-11-8 ChEBI:9169 ChEMBL:CHEMBL221886 PubChem:36119 antibiotic 6640 dehydrogentamicin rickamicin sisomycin sissomicin antibiotic_resistance ARO:0000035 sisomicin ARO:0000035 Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. PMID:10103173 PMID:11083623 PMID:8385262 Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome. CAS:85721-33-1 ChEBI:100241 ChEMBL:CHEMBL8 PubChem:2764 CIP Cipro Ciprobay Ciproxan antibiotic_resistance ARO:0000036 ciprofloxacin ARO:0000036 Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome. PMID:15700957 PMID:15914491 Apramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections in animals. Apramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. CAS:37321-09-8 ChEBI:2790 ChEMBL:CHEMBL1909452 PubChem:3081545 ambylan apralan nebramycin II antibiotic_resistance ARO:0000037 apramycin ARO:0000037 Apramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections in animals. Apramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. PMID:10103173 PMID:11083623 PMID:8385262 Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. CAS:56391-56-1 ChEBI:7528 ChEMBL:CHEMBL1572 PubChem:441306 1-N-aethylsisomicin netilyn netromycin vectacin antibiotic_resistance ARO:0000038 netilmicin ARO:0000038 Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin. PMID:10103173 PMID:11083623 PMID:8385262 Spectinomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Spectinomycin works by binding to the bacterial 30S ribosomal subunit inhibiting translation. CAS:1695-77-8 ChEBI:9215 ChEMBL:CHEMBL1167 PubChem:15541 Actinospectacin Spectam Togamycin Trobicin antibiotic_resistance ARO:0000039 spectinomycin ARO:0000039 Spectinomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Spectinomycin works by binding to the bacterial 30S ribosomal subunit inhibiting translation. PMID:10103173 PMID:11083623 PMID:8385262 Streptomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Streptomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. CAS:57-92-1 ChEBI:17076 ChEMBL:CHEMBL372795 PubChem:19649 streptomycin A streptomycin A sulfate streptomycin sulfate streptomycin sulphate antibiotic_resistance ARO:0000040 streptomycin ARO:0000040 Streptomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Streptomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. PMID:10103173 PMID:11083623 PMID:8385262 Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy. Bacitracin interferes with the dephosphorylation of the C55-isoprenyl pyrophosphate, a molecule which carries the building blocks of the peptidoglycan bacterial cell wall outside of the inner membrane. PubChem:57402735 Altracin Ayfivin BACiiM Baciguent Baciquent Citracin Fortracin Penitracin Topitracin Zutracin antibiotic_resistance ARO:0000041 bacitracin ARO:0000041 Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy. Bacitracin interferes with the dephosphorylation of the C55-isoprenyl pyrophosphate, a molecule which carries the building blocks of the peptidoglycan bacterial cell wall outside of the inner membrane. PMID:8389741 Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance. Presently, there is only one glycylcycline antibiotic for clinical use: tigecycline. It works by inhibiting action of the prokaryotic 30S ribosome, preventing the binding of aminoacyl-tRNA. antibiotic_resistance ARO:0000042 glycylcycline ARO:0000042 Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance. Presently, there is only one glycylcycline antibiotic for clinical use: tigecycline. It works by inhibiting action of the prokaryotic 30S ribosome, preventing the binding of aminoacyl-tRNA. PMID:11381101 Carbenicillin is a semi-synthetic antibiotic belonging to the carboxypenicillin subgroup of the penicillins. It has gram-negative coverage which includes Pseudomonas aeruginosa but limited gram-positive coverage. The carboxypenicillins are susceptible to degradation by beta-lactamase enzymes. Carbenicillin antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. CAS:4697-36-3 ChEBI:3393 ChEMBL:CHEMBL1214 PubChem:20824 Anabactyl CAR Carbecin Carbenicilina Carbenicillina Carbenicilline Carbenicillinum Geopen Microcillin Pyopen antibiotic_resistance ARO:0000043 carbenicillin ARO:0000043 Carbenicillin is a semi-synthetic antibiotic belonging to the carboxypenicillin subgroup of the penicillins. It has gram-negative coverage which includes Pseudomonas aeruginosa but limited gram-positive coverage. The carboxypenicillins are susceptible to degradation by beta-lactamase enzymes. Carbenicillin antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. PMID:11585791 PMID:15673804 PMID:4248289 Acriflavine is a topical antiseptic. It has the form of an orange or brown powder. It may be harmful in the eyes or if inhaled. Acriflavine is also used as treatment for external fungal infections of aquarium fish. ChEMBL:CHEMBL5219994 PubChem:443101 Acriflavin Assiflavine Bialflavina Bioacridin Bovoflavin Buroflavin Choliflavin Euflavine Pantonsiletten Xanthacridinum antibiotic_resistance ARO:0000045 acriflavine ARO:0000045 Acriflavine is a topical antiseptic. It has the form of an orange or brown powder. It may be harmful in the eyes or if inhaled. Acriflavine is also used as treatment for external fungal infections of aquarium fish. PMID:11566977 Lincomycin is a lincosamide antibiotic that comes from the actinomyces Streptomyces lincolnensis. It binds to the 23s portion of the 50S subunit of bacterial ribosomes and inhibit early elongation of peptide chain by inhibiting transpeptidase reaction. CAS:154-21-2 ChEBI:6472 ChEMBL:CHEMBL1447 PubChem:3000540 Cillimycin Epilincomycin Jiemycin Lincocin Lincolcina Lincolnensin Lincomicina Lincomycin A Lincomycine Lincomycinum antibiotic_resistance ARO:0000046 lincomycin ARO:0000046 Lincomycin is a lincosamide antibiotic that comes from the actinomyces Streptomyces lincolnensis. It binds to the 23s portion of the 50S subunit of bacterial ribosomes and inhibit early elongation of peptide chain by inhibiting transpeptidase reaction. PMID:10582867 PMID:15135500 Puromycin is an aminonucleoside antibiotic, derived from Streptomyces alboniger, that causes premature chain termination during ribosomal protein translation. CAS:53-79-2 ChEBI:17939 ChEMBL:CHEMBL469912 PubChem:439530 Puromycin dihydrochloride Puromycin hydrochloride Stylomycin dihydrochloride antibiotic_resistance ARO:0000047 puromycin ARO:0000047 Puromycin is an aminonucleoside antibiotic, derived from Streptomyces alboniger, that causes premature chain termination during ribosomal protein translation. PMID:7608059 Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. CAS:59-01-8 ChEBI:17630 ChEMBL:CHEMBL223520 PubChem:6032 Aminodeoxykanamycin Aspidium Kanamicina Kanamycin sulfate Kanamycine Kanamycinum Kantrex kanamycin antibiotic_resistance ARO:0000049 kanamycin A ARO:0000049 Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. PMID:10103173 PMID:11083623 PMID:8385262 Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. antibiotic_resistance ARO:0000050 streptogramin B antibiotic ARO:0000050 Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. PMID:10582867 PMID:15700955 PMID:9746015 Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome. CAS:60-54-8 ChEBI:27902 ChEMBL:CHEMBL1440 PubChem:54675776 Abricycline Achromycin Agromicina Ambramicina Ambramycin Biocycline Criseociclina Enterocycline Sumycin Tsiklomistsin antibiotic_resistance ARO:0000051 tetracycline ARO:0000051 Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome. PMID:11381101 PMID:19862477 Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. CAS:32986-56-4 ChEBI:28864 ChEMBL:CHEMBL1747 PubChem:36294 Gotabiotic Nebcin Tenebrimycin Tobracin Tobradistin Tobramaxin Tobramicin Tobramitsetin Tobramycetin Tobrex antibiotic_resistance ARO:0000052 tobramycin ARO:0000052 Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. PMID:10103173 PMID:11083623 PMID:8385262 Bleomycin is a family of glycopeptide antibiotics produced by the bacterium Streptomyces verticillus. Bleomycins, taken as a mixture, act by the induction of DNA and RNA strand breaks. In addition to its antibacterial activity, bleomycin is also used as an anticancer agent. ChEBI:22907 ChEMBL:CHEMBL403664 PubChem:5360373 Blenoxane Bleocin Bleomicin Bleomycin sulfate Isobleomycin A2 cu-blenoxane antibiotic_resistance ARO:0000053 bleomycin ARO:0000053 Bleomycin is a family of glycopeptide antibiotics produced by the bacterium Streptomyces verticillus. Bleomycins, taken as a mixture, act by the induction of DNA and RNA strand breaks. In addition to its antibacterial activity, bleomycin is also used as an anticancer agent. PMID:15700963 Bicyclomycin represents a unique class of antibiotics, discovered in 1972. It is obtained by the fermentation of Streptomyces sapporonensis. In the crystalline form bicyclomycin is observed to be rhombic or monoclinic, depending on the solvent used. This antibiotic kills bacteria by inhibiting the Rho transcription terminator factor, halting ribonucleic acid (RNA) synthesis. CAS:38129-37-2 ChEBI:60584 ChEMBL:CHEMBL1231250 PubChem:65807 Aizumycin Bacfeed Bacteron Bicozamicina Bicozamycin Bicozamycine Bicozamycinum antibiotic_resistance ARO:0000055 bicyclomycin ARO:0000055 Bicyclomycin represents a unique class of antibiotics, discovered in 1972. It is obtained by the fermentation of Streptomyces sapporonensis. In the crystalline form bicyclomycin is observed to be rhombic or monoclinic, depending on the solvent used. This antibiotic kills bacteria by inhibiting the Rho transcription terminator factor, halting ribonucleic acid (RNA) synthesis. PMID:16181146 PMID:7487110 Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. CAS:66-79-5 ChEBI:7809 ChEMBL:CHEMBL819 PubChem:6196 MPI-penicillin Ossacillina Oxacilina Oxacilline Oxacillinum Oxazocillin Oxazocilline Prostaphlin Prostaphlyn antibiotic_resistance ARO:0000056 oxacillin ARO:0000056 Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis. PMID:7928809 Telithromycin is a semi-synthetic derivative of erythromycin. It is a 14-membered macrolide and is the first ketolide antibiotic to be used in clinics. Telithromycin binds the 50S subunit of the bacterial ribosome to inhibit protein synthesis. CAS:191114-48-4 ChEBI:29688 ChEMBL:CHEMBL1136 PubChem:3002190 HMR-3647 HMR3647 Ketek Levviax antibiotic_resistance ARO:0000057 telithromycin ARO:0000057 Telithromycin is a semi-synthetic derivative of erythromycin. It is a 14-membered macrolide and is the first ketolide antibiotic to be used in clinics. Telithromycin binds the 50S subunit of the bacterial ribosome to inhibit protein synthesis. PMID:15700954 Cefazolin, also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. CAS:25953-19-9 ChEBI:474053 ChEMBL:CHEMBL1435 PubChem:33255 CFZ Cefamezin Cefazolina Cefazoline Cefazolinum Cephamezine Cephazolidin Cephazolin Cephazoline Elzogram antibiotic_resistance ARO:0000058 cefazolin ARO:0000058 Cefazolin, also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic. It is administered parenterally, and is active against a broad spectrum of bacteria. PMID:27572414 PMID:4790605 Cefepime (INN) is a fourth-generation cephalosporin antibiotic developed in 1994. It contains an aminothiazolyl group that decreases its affinity with beta-lactamases. Cefepime shows high binding affinity with penicillin-binding proteins and has an extended spectrum of activity against Gram-positive and Gram-negative bacteria, with greater activity against both Gram-negative and Gram-positive organisms than third-generation agents. CAS:88040-23-7 ChEBI:478164 ChEMBL:CHEMBL186 PubChem:5479537 Axepim Cefepima Cefepimum FEP Maxipime antibiotic_resistance ARO:0000059 cefepime ARO:0000059 Cefepime (INN) is a fourth-generation cephalosporin antibiotic developed in 1994. It contains an aminothiazolyl group that decreases its affinity with beta-lactamases. Cefepime shows high binding affinity with penicillin-binding proteins and has an extended spectrum of activity against Gram-positive and Gram-negative bacteria, with greater activity against both Gram-negative and Gram-positive organisms than third-generation agents. PMID:8150771 Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections. CAS:72558-82-8 ChEBI:3508 ChEMBL:CHEMBL44354 PubChem:5481173 CAZ Ceftazidim Ceptaz Fortaz Pentacef Tazicef Tazidime caftazidime ceftazidima ceftazidimum antibiotic_resistance ARO:0000060 ceftazidime ARO:0000060 Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections. PMID:6805421 Ceftobiprole (Zeftera/Zevtera) is a next generation (5th generation) cephalosporin antibiotic with activity against methicillin-resistant Staphylococcus aureus, penicillin-resistant Streptococcus pneumoniae, Pseudomonas aeruginosa, and Enterococci. Ceftobiprole inhibits transpeptidases essential to building cell walls, and is a poor substrate for most beta-lactamases. CAS:209467-52-7 ChEBI:140407 ChEMBL:CHEMBL520642 PubChem:135413542 Ceftobiprole medocaril Zeftera Zevtera antibiotic_resistance ARO:0000061 ceftobiprole ARO:0000061 Ceftobiprole (Zeftera/Zevtera) is a next generation (5th generation) cephalosporin antibiotic with activity against methicillin-resistant Staphylococcus aureus, penicillin-resistant Streptococcus pneumoniae, Pseudomonas aeruginosa, and Enterococci. Ceftobiprole inhibits transpeptidases essential to building cell walls, and is a poor substrate for most beta-lactamases. PMID:22064544 Ceftriaxone is a third-generation cephalosporin antibiotic. The presence of an aminothiazolyl sidechain increases ceftriazone's resistance to beta-lactamases. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. CAS:73384-59-5 ChEBI:29007 ChEMBL:CHEMBL161 PubChem:5479530 Biotrakson CRO Cefatriaxone Ceftriaxon Ceftriaxona Ceftriaxonum Ceftriazone Longacef Longaceph Rocephin antibiotic_resistance ARO:0000062 ceftriaxone ARO:0000062 Ceftriaxone is a third-generation cephalosporin antibiotic. The presence of an aminothiazolyl sidechain increases ceftriazone's resistance to beta-lactamases. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. PMID:6810737 Cefuroxime is a second-generation cephalosporin antibiotic with increased stability with beta-lactamases than first-generation cephalosporins. Cefuroxime is active against Gram-positive organisms but less active against methicillin-resistant strains. CAS:55268-75-2 ChEBI:3515 ChEMBL:CHEMBL1436 PubChem:5479529 Biofuroksym CXM Cefuril Cefuroxim Cefuroximo Cefuroximum Cephuroxime Sharox Zinacef antibiotic_resistance ARO:0000063 cefuroxime ARO:0000063 Cefuroxime is a second-generation cephalosporin antibiotic with increased stability with beta-lactamases than first-generation cephalosporins. Cefuroxime is active against Gram-positive organisms but less active against methicillin-resistant strains. PMID:1259408 Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan. CAS:26787-78-0 ChEBI:2676 ChEMBL:CHEMBL1082 PubChem:33613 AMX Amolin Amopenixin Amoxicilina Amoxicilline Amoxicillinum Amoxycillin Clamoxyl D-Amoxicillin Moxal antibiotic_resistance ARO:0000064 amoxicillin ARO:0000064 Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan. PMID:19236222 Clarithromycin is a methyl derivative of erythromycin, sharing the 14-carbon macrolide ring. The antibiotic binds to the 50S subunit of the ribosome and is used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia (especially atypical pneumonias associated with Chlamydia pneumoniae or TWAR), and skin structure infections. CAS:81103-11-9 ChEBI:3732 ChEMBL:CHEMBL1741 PubChem:84029 Biaxin CLR Clambiotic Clarith Clathromycin Klacid Klaricid Macladin Naxy Veclam antibiotic_resistance ARO:0000065 clarithromycin ARO:0000065 Clarithromycin is a methyl derivative of erythromycin, sharing the 14-carbon macrolide ring. The antibiotic binds to the 50S subunit of the ribosome and is used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia (especially atypical pneumonias associated with Chlamydia pneumoniae or TWAR), and skin structure infections. PMID:7683018 Clindamycin is a lincosamide antibiotic that blocks A-site aminoacyl-tRNA binding. It is usually used to treat infections with anaerobic bacteria but can also be used to treat some protozoal diseases, such as malaria. CAS:18323-44-9 ChEBI:3745 ChEMBL:CHEMBL1753 PubChem:446598 CLI Chlolincocin Chlorlincocin Cleocin Clindamicina Clindamycine Clindamycinum Clinimycin Sobelin antibiotic_resistance ARO:0000066 clindamycin ARO:0000066 Clindamycin is a lincosamide antibiotic that blocks A-site aminoacyl-tRNA binding. It is usually used to treat infections with anaerobic bacteria but can also be used to treat some protozoal diseases, such as malaria. PMID:20876128 Colistins are polymyxin antibiotics produced by certain strains of Bacillus polymyxa var. colistinus. Colistin, also referred to as polymyxin E, is a mixture of cyclic polypeptides colistin A and B which disrupt the bacterial cell membrane and is effective against Gram-negative bacteria. CST Colomycin polymyxin E antibiotic_resistance ARO:0000067 colistin ARO:0000067 Colistins are polymyxin antibiotics produced by certain strains of Bacillus polymyxa var. colistinus. Colistin, also referred to as polymyxin E, is a mixture of cyclic polypeptides colistin A and B which disrupt the bacterial cell membrane and is effective against Gram-negative bacteria. PMID:17958555 PMID:20818945 Daptomycin is a novel lipopeptide antibiotic used in the treatment of certain infections caused by Gram-positive organisms. Daptomycin interferes with the bacterial cell membrane, reducing membrane potential and inhibiting cell wall synthesis. PubChem:16134395 Cidecin Cubicin Daptomicina Daptomycine Daptomycinum Deptomycin antibiotic_resistance ARO:0000068 daptomycin ARO:0000068 Daptomycin is a novel lipopeptide antibiotic used in the treatment of certain infections caused by Gram-positive organisms. Daptomycin interferes with the bacterial cell membrane, reducing membrane potential and inhibiting cell wall synthesis. PMID:11353654 PMID:12615866 PMID:14985278 PMID:15870461 PMID:16311632 PMID:20522545 PMID:22083474 Doxycycline is second generation semi-synthetic derivative of the tetracycline group of antibiotics. It inhibits bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome and preventing the aminotransferase-tRNA from associating with the ribosome. CAS:564-25-0 ChEBI:50845 ChEMBL:CHEMBL1200699 PubChem:54671203 Azudoxat Deoxymykoin Doxiciclina Doxitard Doxycyclinum Doxytetracycline Vibramycin Vibramycine Vibravenos antibiotic_resistance ARO:0000069 doxycycline ARO:0000069 Doxycycline is second generation semi-synthetic derivative of the tetracycline group of antibiotics. It inhibits bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome and preventing the aminotransferase-tRNA from associating with the ribosome. PMID:11381101 PMID:19862477 Ertapenem is a carbapenem antibiotic and is highly resistant to beta-lactamases like other carbapenems. It inhibits bacterial cell wall synthesis. CAS:153832-46-3 ChEBI:404903 ChEMBL:CHEMBL1359 PubChem:150610 ERT Invanz antibiotic_resistance ARO:0000070 ertapenem ARO:0000070 Ertapenem is a carbapenem antibiotic and is highly resistant to beta-lactamases like other carbapenems. It inhibits bacterial cell wall synthesis. PMID:12951340 PMID:27572414 Levofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class. Its main target is topoisomerase IV, inhibiting its function and disrupting DNA replication. CAS:100986-85-4 ChEBI:63598 ChEMBL:CHEMBL5315124 PubChem:149096 Levaquin Tavanic antibiotic_resistance ARO:0000071 levofloxacin ARO:0000071 Levofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class. Its main target is topoisomerase IV, inhibiting its function and disrupting DNA replication. PMID:15700957 Linezolid is a synthetic antibiotic used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics. It inhibits protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes. CAS:165800-03-3 ChEBI:63607 ChEMBL:CHEMBL126 PubChem:441401 Zyvox Zyvoxa Zyvoxam Zyvoxid antibiotic_resistance ARO:0000072 linezolid ARO:0000072 Linezolid is a synthetic antibiotic used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics. It inhibits protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes. PMID:15700955 PMID:18757750 Meropenem is an ultra-broad spectrum injectable antibiotic used to treat a wide variety of infections, including meningitis and pneumonia. It is a beta-lactam and belongs to the subgroup of carbapenem, similar to imipenem and ertapenem. CAS:96036-03-2 ChEBI:43968 ChEMBL:CHEMBL127 PubChem:441130 MER Meronem Meropen Meropenem anhydrous Meropenemum Merrem antibiotic_resistance ARO:0000073 meropenem ARO:0000073 Meropenem is an ultra-broad spectrum injectable antibiotic used to treat a wide variety of infections, including meningitis and pneumonia. It is a beta-lactam and belongs to the subgroup of carbapenem, similar to imipenem and ertapenem. PMID:18416587 Moxifloxacin is a fourth generation synthetic fluoroquinolone chemotherapeutic agent, and has been shown to be significantly more active than levofloxacin (4 to 8 times more) against Streptococcus pneumoniae. It acts by inhibiting bacterial DNA topoisomerases. CAS:151096-09-2 ChEBI:63611 ChEMBL:CHEMBL32 PubChem:152946 Actira (hydrochloride) Avelox Avelox (hydrochloride) MXFX Moxifloxacin hydrochloride Vigamox antibiotic_resistance ARO:0000074 moxifloxacin ARO:0000074 Moxifloxacin is a fourth generation synthetic fluoroquinolone chemotherapeutic agent, and has been shown to be significantly more active than levofloxacin (4 to 8 times more) against Streptococcus pneumoniae. It acts by inhibiting bacterial DNA topoisomerases. PMID:10193688 PMID:11858629 Nitrofurantoin is an antibiotic used to treat urinary tract infections. It inhibits enzyme synthesis by inhibiting essential enzymes involved in the citric acid cycle, as well as those involved in DNA, RNA, and protein synthesis. It is marketed under the following brand names: Furadantin, Macrobid, Macrodantin, Nitro Macro and Urantoin. CAS:67-20-9 ChEBI:71415 ChEMBL:CHEMBL572 PubChem:6604200 Chemiofuran Cistofuran Furadantin Furadantine Furalan Macrobid Macrodantin Macrodantina Nitrofuradantin antibiotic_resistance ARO:0000075 nitrofurantoin ARO:0000075 Nitrofurantoin is an antibiotic used to treat urinary tract infections. It inhibits enzyme synthesis by inhibiting essential enzymes involved in the citric acid cycle, as well as those involved in DNA, RNA, and protein synthesis. It is marketed under the following brand names: Furadantin, Macrobid, Macrodantin, Nitro Macro and Urantoin. PMID:1100114 PMID:7928834 Resistance-modifying agents (RMA) include antibiotic adjuvants and other inhibitors of antibiotic resistance, as well as antibiotic potentiators. These are non-antibiotic compounds which act to block resistance mechanisms or enhance antibiotic action. These are often delivered in combination with an antibiotic (e.g. amoxicillin-clavulanic acid) and may either affect the host organism or the pathogen. Adjuvants and potentiators are therefore used to rescue the activity of existing antibiotic drugs, and are researched as an alternative solution to the antibiotic resistance crisis. antibiotic_resistance ARO:0000076 resistance-modifying agents ARO:0000076 Tazobactam is a compound which inhibits the action of bacterial beta-lactamases. CAS:89786-04-9 ChEBI:9421 ChEMBL:CHEMBL404 PubChem:123630 Zosyn antibiotic_resistance ARO:0000077 tazobactam ARO:0000077 Piperacillin is an acetylureidopenicillin and has an extended spectrum of targets relative to other beta-lactam antibiotics. It inhibits cell wall synthesis in bacteria, and is usually taken with the beta-lactamase inhibitor tazobactam to overcome penicillin-resistant bacteria. CAS:61477-96-1 ChEBI:8232 ChEMBL:CHEMBL702 PubChem:43672 Piperacillin anhydrous Piperacillin sodium Pipercillin Pipracil Pipril antibiotic_resistance ARO:0000078 piperacillin ARO:0000078 Piperacillin is an acetylureidopenicillin and has an extended spectrum of targets relative to other beta-lactam antibiotics. It inhibits cell wall synthesis in bacteria, and is usually taken with the beta-lactamase inhibitor tazobactam to overcome penicillin-resistant bacteria. PMID:11735679 Clavulanic acid is a beta-lactamase inhibitor (marketed by GlaxoSmithKline, formerly Beecham) combined with penicillin group antibiotics to overcome certain types of antibiotic resistance. It is used to overcome resistance in bacteria that secrete beta-lactamase, which otherwise inactivates most penicillins. CAS:58001-44-8 ChEBI:48947 ChEMBL:CHEMBL777 PubChem:5280980 Acide clavulanique Acido clavulanico Clavulansaeure Clavulox Isoclavulanic acid Sodium Clavulanate acidum clavulanicum clavulanate antibiotic_resistance ARO:0000079 clavulanic acid ARO:0000079 Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance. antibiotic_resistance ARO:0001001 antibiotic target alteration ARO:0001001 Replacement or substitution of antibiotic action target, which process will result in antibiotic resistance. antibiotic target substitution antibiotic_resistance ARO:0001002 antibiotic target replacement ARO:0001002 Protection of antibiotic action target from antibiotic binding, which process will result in antibiotic resistance. antibiotic_resistance ARO:0001003 antibiotic target protection ARO:0001003 Protection of antibiotic action target from antibiotic binding, which process will result in antibiotic resistance. PMID:32587401 Enzymatic inactivation of antibiotic to confer drug resistance. drug enzymatic inactivation drug enzymatic modification antibiotic_resistance ARO:0001004 antibiotic inactivation ARO:0001004 Enzymatic inactivation of antibiotic to confer drug resistance. PMID:20564281 Antibiotic resistance via the transport of antibiotics out of the cell. antibiotic_resistance ARO:0010000 antibiotic efflux ARO:0010000 Antibiotic resistance via the transport of antibiotics out of the cell. PMID:19678712 Directed pumping of antibiotic out of a cell to confer resistance. ATP-binding cassette (ABC) transporters are present in all cells of all organisms and use the energy of ATP binding/hydrolysis to transport substrates across cell membranes. ABC type drug efflux antibiotic_resistance ARO:0010001 ATP-binding cassette (ABC) antibiotic efflux pump ARO:0010001 Directed pumping of antibiotic out of a cell to confer resistance. ATP-binding cassette (ABC) transporters are present in all cells of all organisms and use the energy of ATP binding/hydrolysis to transport substrates across cell membranes. PMID:8302219 Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient. MFS type drug efflux antibiotic_resistance ARO:0010002 major facilitator superfamily (MFS) antibiotic efflux pump ARO:0010002 Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient. PMID:10943556 PMID:19678712 PMID:9529885 Directed pumping of antibiotic out of a cell to confer resistance. Small multidrug resistance (SMR) proteins are a relatively small family of transporters, restricted to prokaryotic cells. They are also the smallest multidrug transporters, with only four transmembrane alpha-helices and no significant extramembrane domain. SMR type drug efflux antibiotic_resistance ARO:0010003 small multidrug resistance (SMR) antibiotic efflux pump ARO:0010003 Directed pumping of antibiotic out of a cell to confer resistance. Small multidrug resistance (SMR) proteins are a relatively small family of transporters, restricted to prokaryotic cells. They are also the smallest multidrug transporters, with only four transmembrane alpha-helices and no significant extramembrane domain. PMID:17942072 Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient. RND type drug efflux antibiotic_resistance ARO:0010004 resistance-nodulation-cell division (RND) antibiotic efflux pump ARO:0010004 Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient. PMID:15582398 PMID:16915237 PMID:19664953 Antibiotic resistance is the ability of a microorganism to withstand the effects of an antibiotic. It is a specific type of drug resistance. antibiotic_resistance ARO:1000001 process or component of antibiotic biology or chemistry ARO:1000001 Antibiotic resistance mechanisms evolve naturally via natural selection through random mutation, but it could also be engineered by applying an evolutionary stress on a population. antibiotic_resistance ARO:1000002 mechanism of antibiotic resistance ARO:1000002 Antibiotics are commonly classified based on their mechanism of action, chemical structure or spectrum of activity. antibiotic_resistance ARO:1000003 antibiotic molecule ARO:1000003 Homology that is defined by similarity with regard to selected stoichiometrical parameters. antibiotic_resistance ARO:2000005 stoichiometrically_homologous_to ARO:2000005 Homology that is defined by similarity with regard to selected structural parameters. antibiotic_resistance ARO:2000006 structurally_homologous_to ARO:2000006 A mutation, single nucleotide polymorphism, gene, or gene product that confers antibiotic resistance. antibiotic_resistance ARO:3000000 determinant of antibiotic resistance ARO:3000000 A mutation, single nucleotide polymorphism, gene, or gene product that confers antibiotic resistance. PMID:15700955 Beta-lactamases are enzymes (EC 3.5.2.6) produced by some bacteria and are responsible for their resistance to beta-lactam antibiotics like penicillins, cephalosporins (are relatively resistant to beta-lactamase), cephamycins, and carbapenems (ertapenem). These antibiotics have a common element in their molecular structure: a four-atom ring known as a beta-lactam. The lactamase enzyme breaks that ring open, deactivating the molecule's antibacterial properties. Beta-lactam antibiotics are typically used to treat a broad spectrum of gram-positive and gram-negative bacteria. Beta-lactamases produced by gram-negative organisms are usually secreted. antibiotic_resistance ARO:3000001 beta-lactamase ARO:3000001 Beta-lactamases are enzymes (EC 3.5.2.6) produced by some bacteria and are responsible for their resistance to beta-lactam antibiotics like penicillins, cephalosporins (are relatively resistant to beta-lactamase), cephamycins, and carbapenems (ertapenem). These antibiotics have a common element in their molecular structure: a four-atom ring known as a beta-lactam. The lactamase enzyme breaks that ring open, deactivating the molecule's antibacterial properties. Beta-lactam antibiotics are typically used to treat a broad spectrum of gram-positive and gram-negative bacteria. Beta-lactamases produced by gram-negative organisms are usually secreted. PMID:19995920 PMID:21220461 PMID:6109327 PMID:7574506 vanW is an accessory gene, with unknown function, found on vancomycin resistance operons. antibiotic_resistance ARO:3000002 vanW ARO:3000002 vanW is an accessory gene, with unknown function, found on vancomycin resistance operons. PMID:11036060 These compounds are antibiotics of unique structure or origin, without a defined classification. miscellaneous antibiotic antibiotic_resistance ARO:3000003 antibiotic without defined classification ARO:3000003 Ambler Class B beta-lactamases are the metallo-beta-lactamases. These enzymes possess one or two zinc ions in the active site, which are used to orient a hydroxide nucleophile to attack the carbonyl on a beta-lactam ring. There are currently no inhibitors in late-stage development for these relatively new beta-lactamases. Molecular Class B beta-lactamase antibiotic_resistance ARO:3000004 class B (metallo-) beta-lactamase ARO:3000004 Ambler Class B beta-lactamases are the metallo-beta-lactamases. These enzymes possess one or two zinc ions in the active site, which are used to orient a hydroxide nucleophile to attack the carbonyl on a beta-lactam ring. There are currently no inhibitors in late-stage development for these relatively new beta-lactamases. PMID:14629034 PMID:15215079 VanD is a D-Ala-D-Ala ligase homolog similar to VanA, and can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance. vanD antibiotic_resistance ARO:3000005 vanD ARO:3000005 VanD is a D-Ala-D-Ala ligase homolog similar to VanA, and can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance. PMID:10368136 vanD VanH is a D-specific alpha-ketoacid dehydrogenase that synthesizes D-lactate. D-lactate is incorporated into the end of the peptidoglycan subunits, decreasing vancomycin binding affinity. antibiotic_resistance ARO:3000006 vanH ARO:3000006 VanH is a D-specific alpha-ketoacid dehydrogenase that synthesizes D-lactate. D-lactate is incorporated into the end of the peptidoglycan subunits, decreasing vancomycin binding affinity. PMID:1931965 PMID:9177243 Beta-lactam antibiotics are a broad class of antibiotics that include penams (penicillin derivatives), cephems (cephalosporins), monobactams, and carbapenems. These antibiotic agents contain a beta-lactam nucleus in its molecular structure. They are the most widely-used group of antibiotics. antibiotic_resistance ARO:3000007 beta-lactam antibiotic ARO:3000007 Beta-lactam antibiotics are a broad class of antibiotics that include penams (penicillin derivatives), cephems (cephalosporins), monobactams, and carbapenems. These antibiotic agents contain a beta-lactam nucleus in its molecular structure. They are the most widely-used group of antibiotics. PMID:3889939 Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. penam antibiotic_resistance ARO:3000008 penicillin beta-lactam ARO:3000008 Penicilins (Penams) are a group of antibiotics derived from Penicillium fungi that share a skeleton beta-lactam moiety fused with a thiazolidine ring. Penicillin-like antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. PMID:3889939 VanA is a D-Ala-D-Ala ligase homolog that synthesizes D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It has been isolated from VREs. It is associated with both vancomycin and teicoplanin resistance. PDB:1E4E vanA antibiotic_resistance ARO:3000010 vanA ARO:3000010 VanA is a D-Ala-D-Ala ligase homolog that synthesizes D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It has been isolated from VREs. It is associated with both vancomycin and teicoplanin resistance. PMID:9177243 vanA VanX is a D,D-dipeptidase that cleaves D-Ala-D-Ala but not D-Ala-D-Lac, ensuring that the latter dipeptide that has reduced binding affinity with vancomycin is used to synthesize peptidoglycan substrate. antibiotic_resistance ARO:3000011 vanX ARO:3000011 VanX is a D,D-dipeptidase that cleaves D-Ala-D-Ala but not D-Ala-D-Lac, ensuring that the latter dipeptide that has reduced binding affinity with vancomycin is used to synthesize peptidoglycan substrate. PMID:7854121 Proteins involved in restructuring of the cell wall, causing antibiotic resistance. antibiotic_resistance ARO:3000012 protein(s) conferring antibiotic resistance via molecular bypass ARO:3000012 VanB is a D-Ala-D-Ala ligase homolog similar to VanA, and can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It has been isolated from VREs. It is associated with vancomycin resistance, but not teicoplanin resistance. vanB antibiotic_resistance ARO:3000013 vanB ARO:3000013 VanB is a D-Ala-D-Ala ligase homolog similar to VanA, and can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It has been isolated from VREs. It is associated with vancomycin resistance, but not teicoplanin resistance. PMID:9177243 vanB TEM-1 is the most commonly-encountered beta-lactamase in gram-negative bacteria. Up to 90% of ampicillin resistance in E. coli is due to the production of TEM-1. Also responsible for the ampicillin and penicillin resistance that is seen in H. influenzae and N. gonorrhoeae in increasing numbers. Although TEM-type beta-lactamases are most often found in E. coli and K. pneumoniae, they are also found in other species of gram-negative bacteria with increasing frequency. The amino acid substitutions responsible for the ESBL phenotype cluster around the active site of the enzyme and change its configuration, allowing access to oxyimino-beta-lactam substrates. Opening the active site to beta-lactam substrates also typically enhances the susceptibility of the enzyme to b-lactamase inhibitors, such as clavulanic acid. Although the inhibitor-resistant beta-lactamases are not ESBLs, they are often discussed with ESBLs because they are also derivatives of the classical TEM- or SHV-type enzymes. These enzymes were at first given the designation IRT for inhibitor-resistant TEM beta-lactamase; however, all have subsequently been renamed with numerical TEM designations. There are at least 19 distinct inhibitor-resistant TEM beta-lactamases. Inhibitor-resistant TEM beta-lactamases have been found mainly in clinical isolates of E. coli, but also some strains of K. pneumoniae, Klebsiella oxytoca, P. mirabilis, and Citrobacter freundii. Although the inhibitor-resistant TEM variants are resistant to inhibition by clavulanic acid and sulbactam, thereby showing clinical resistance to the beta-lactam-lactamase inhibitor combinations of amoxicillin-clavulanate (Co-amoxiclav), ticarcillin-clavulanate, and ampicillin/sulbactam, they normally remain susceptible to inhibition by tazobactam and subsequently the combination of piperacillin/tazobactam, although resistance has been described. antibiotic_resistance ARO:3000014 TEM beta-lactamase ARO:3000014 TEM-1 is the most commonly-encountered beta-lactamase in gram-negative bacteria. Up to 90% of ampicillin resistance in E. coli is due to the production of TEM-1. Also responsible for the ampicillin and penicillin resistance that is seen in H. influenzae and N. gonorrhoeae in increasing numbers. Although TEM-type beta-lactamases are most often found in E. coli and K. pneumoniae, they are also found in other species of gram-negative bacteria with increasing frequency. The amino acid substitutions responsible for the ESBL phenotype cluster around the active site of the enzyme and change its configuration, allowing access to oxyimino-beta-lactam substrates. Opening the active site to beta-lactam substrates also typically enhances the susceptibility of the enzyme to b-lactamase inhibitors, such as clavulanic acid. Although the inhibitor-resistant beta-lactamases are not ESBLs, they are often discussed with ESBLs because they are also derivatives of the classical TEM- or SHV-type enzymes. These enzymes were at first given the designation IRT for inhibitor-resistant TEM beta-lactamase; however, all have subsequently been renamed with numerical TEM designations. There are at least 19 distinct inhibitor-resistant TEM beta-lactamases. Inhibitor-resistant TEM beta-lactamases have been found mainly in clinical isolates of E. coli, but also some strains of K. pneumoniae, Klebsiella oxytoca, P. mirabilis, and Citrobacter freundii. Although the inhibitor-resistant TEM variants are resistant to inhibition by clavulanic acid and sulbactam, thereby showing clinical resistance to the beta-lactam-lactamase inhibitor combinations of amoxicillin-clavulanate (Co-amoxiclav), ticarcillin-clavulanate, and ampicillin/sulbactam, they normally remain susceptible to inhibition by tazobactam and subsequently the combination of piperacillin/tazobactam, although resistance has been described. PMID:11585791 PMID:8432315 SHV-1 shares 68 percent of its amino acids with TEM-1 and has a similar overall structure. The SHV-1 beta-lactamase is most commonly found in K. pneumoniae and is responsible for up to 20% of the plasmid-mediated ampicillin resistance in this species. ESBLs in this family also have amino acid changes around the active site, most commonly at positions 238 or 238 and 240. More than 60 SHV varieties are known. antibiotic_resistance ARO:3000015 SHV beta-lactamase ARO:3000015 SHV-1 shares 68 percent of its amino acids with TEM-1 and has a similar overall structure. The SHV-1 beta-lactamase is most commonly found in K. pneumoniae and is responsible for up to 20% of the plasmid-mediated ampicillin resistance in this species. ESBLs in this family also have amino acid changes around the active site, most commonly at positions 238 or 238 and 240. More than 60 SHV varieties are known. PMID:11585791 These enzymes were named for their greater activity against cefotaxime than other oxyimino-beta-lactam substrates (eg, ceftazidime, ceftriaxone, or cefepime). Rather than arising by mutation, they represent examples of plasmid acquisition of beta-lactamase genes normally found on the chromosome of Kluyvera species, a group of rarely pathogenic commensal organisms. These enzymes are not very closely related to TEM or SHV beta-lactamases in that they show only approximately 40% identity with these two commonly isolated beta-lactamases. Despite their name, a few are more active on ceftazidime than cefotaxime. CTX-M-15 was recently found in bacterial strains expressing NDM-1 and were responsible for resistance to aztreonam. antibiotic_resistance ARO:3000016 CTX-M beta-lactamase ARO:3000016 These enzymes were named for their greater activity against cefotaxime than other oxyimino-beta-lactam substrates (eg, ceftazidime, ceftriaxone, or cefepime). Rather than arising by mutation, they represent examples of plasmid acquisition of beta-lactamase genes normally found on the chromosome of Kluyvera species, a group of rarely pathogenic commensal organisms. These enzymes are not very closely related to TEM or SHV beta-lactamases in that they show only approximately 40% identity with these two commonly isolated beta-lactamases. Despite their name, a few are more active on ceftazidime than cefotaxime. CTX-M-15 was recently found in bacterial strains expressing NDM-1 and were responsible for resistance to aztreonam. PMID:20705517 OXA beta-lactamases were long recognized as a less common but also plasmid-mediated beta-lactamase variety that could hydrolyze oxacillin and related anti-staphylococcal penicillins. These beta-lactamases differ from the TEM and SHV enzymes in that they belong to molecular class D and functional group 2d. The OXA-type beta-lactamases confer resistance to ampicillin and cephalothin and are characterized by their high hydrolytic activity against oxacillin and cloxacillin and the fact that they are poorly inhibited by clavulanic acid. Amino acid substitutions in OXA enzymes can also give the ESBL phenotype. The OXA beta-lactamase family was originally created as a phenotypic rather than a genotypic group for a few beta-lactamases that had a specific hydrolysis profile. Therefore, there is as little as 20% sequence homology among some of the members of this family. However, recent additions to this family show some degree of homology to one or more of the existing members of the OXA beta-lactamase family. Some confer resistance predominantly to ceftazidime, but OXA-17 confers greater resistance to cefotaxime and cefepime than it does resistance to ceftazidime. antibiotic_resistance ARO:3000017 OXA beta-lactamase ARO:3000017 OXA beta-lactamases were long recognized as a less common but also plasmid-mediated beta-lactamase variety that could hydrolyze oxacillin and related anti-staphylococcal penicillins. These beta-lactamases differ from the TEM and SHV enzymes in that they belong to molecular class D and functional group 2d. The OXA-type beta-lactamases confer resistance to ampicillin and cephalothin and are characterized by their high hydrolytic activity against oxacillin and cloxacillin and the fact that they are poorly inhibited by clavulanic acid. Amino acid substitutions in OXA enzymes can also give the ESBL phenotype. The OXA beta-lactamase family was originally created as a phenotypic rather than a genotypic group for a few beta-lactamases that had a specific hydrolysis profile. Therefore, there is as little as 20% sequence homology among some of the members of this family. However, recent additions to this family show some degree of homology to one or more of the existing members of the OXA beta-lactamase family. Some confer resistance predominantly to ceftazidime, but OXA-17 confers greater resistance to cefotaxime and cefepime than it does resistance to ceftazidime. PMID:16891520 PMID:24696435 IMI beta-lactamases are a group of TEM-1-like beta-lactamase that are known to hydrolyze imipenem. IMI beta-lactamases are inhibited by clavulanic acid and tazobactam. antibiotic_resistance ARO:3000018 IMI beta-lactamase ARO:3000018 IMI beta-lactamases are a group of TEM-1-like beta-lactamase that are known to hydrolyze imipenem. IMI beta-lactamases are inhibited by clavulanic acid and tazobactam. PMID:8878585 Plasmid mediated IMP-type carbapenemases, of which at least 26 varieties are currently known, became established in Japan in the 1990s in enteric gram-negative organisms, Pseudomonas and Acinetobacter species. Integron-associated, sometimes within plasmids. Hydrolyses all beta-lactams except monobactams, and evades all beta-lactam inhibitors. antibiotic_resistance ARO:3000020 IMP beta-lactamase ARO:3000020 Plasmid mediated IMP-type carbapenemases, of which at least 26 varieties are currently known, became established in Japan in the 1990s in enteric gram-negative organisms, Pseudomonas and Acinetobacter species. Integron-associated, sometimes within plasmids. Hydrolyses all beta-lactams except monobactams, and evades all beta-lactam inhibitors. PMID:20121112 PMID:8141584 The Verone integron-encoded metallo-beta-lactamase (VIM) family was reported from Italy in 1999. There are, to date, 23 reported variants. VIM enzymes mostly occur in P. aeruginosa, also P. putida and, very rarely, Enterobacteriaceae. Integron-associated, sometimes within plasmids. Hydrolyses all beta-lactams except monobactams, and evades all beta-lactam inhibitors. There is a strong incidence of these in East Asia. antibiotic_resistance ARO:3000021 VIM beta-lactamase ARO:3000021 The Verone integron-encoded metallo-beta-lactamase (VIM) family was reported from Italy in 1999. There are, to date, 23 reported variants. VIM enzymes mostly occur in P. aeruginosa, also P. putida and, very rarely, Enterobacteriaceae. Integron-associated, sometimes within plasmids. Hydrolyses all beta-lactams except monobactams, and evades all beta-lactam inhibitors. There is a strong incidence of these in East Asia. PMID:12562689 PMID:18061205 PMID:20121112 Ristocetin is a glycopeptide antibiotic similar to vancomycin but positively charged. It is not used clinically because it induces platelet agglutination. CAS:1404-55-3 ChEBI:85129 ChEMBL:CHEMBL1095986 PubChem:16204749 antibiotic_resistance ARO:3000022 ristocetin ARO:3000022 Ristocetin is a glycopeptide antibiotic similar to vancomycin but positively charged. It is not used clinically because it induces platelet agglutination. PMID:17620 PMID:2532132 Subunit of the topoisomerase IV sensitive to aminocoumarins. antibiotic_resistance ARO:3000023 aminocoumarin sensitive parE ARO:3000023 Subunit of the topoisomerase IV sensitive to aminocoumarins. PMID:12604514 PMID:16127057 PatA is an ABC transporter of Streptococcus pneumoniae that interacts with PatB to confer fluoroquinolone resistance. patA antibiotic_resistance ARO:3000024 patA ARO:3000024 PatA is an ABC transporter of Streptococcus pneumoniae that interacts with PatB to confer fluoroquinolone resistance. PMID:20709735 PMID:20937787 patA PatB is an ABC transporter of Streptococcus pneumoniae that interacts with PatA to confer fluoroquinolone resistance.. patB antibiotic_resistance ARO:3000025 patB ARO:3000025 PatB is an ABC transporter of Streptococcus pneumoniae that interacts with PatA to confer fluoroquinolone resistance.. PMID:20709735 PMID:20937787 patB MepA is an efflux protein regulated by MepR and part of the MepRAB cluster. Its presence in Staphylococcus aureus led to multidrug resistance, while it has also been shown to decrease tigecycline susceptibility. mepA antibiotic_resistance ARO:3000026 mepA ARO:3000026 MepA is an efflux protein regulated by MepR and part of the MepRAB cluster. Its presence in Staphylococcus aureus led to multidrug resistance, while it has also been shown to decrease tigecycline susceptibility. PMID:15855507 PMID:15855508 PMID:16569840 mepA EmrA is a membrane fusion protein, providing an efflux pathway with EmrB and TolC between the inner and outer membranes of E. coli, a Gram-negative bacterium. emrA antibiotic_resistance ARO:3000027 emrA ARO:3000027 EmrA is a membrane fusion protein, providing an efflux pathway with EmrB and TolC between the inner and outer membranes of E. coli, a Gram-negative bacterium. PMID:7730261 emrA Nucleoside antibiotics are made of modified nucleosides and nucleotides with wide-ranging activities and means of antibacterial effects. This drug class includes aminonucleoside antibiotics, which contain an amino group. antibiotic_resistance ARO:3000034 nucleoside antibiotic ARO:3000034 Nucleoside antibiotics are made of modified nucleosides and nucleotides with wide-ranging activities and means of antibacterial effects. This drug class includes aminonucleoside antibiotics, which contain an amino group. PMID:18679046 PMID:3061990 Lipopeptide antibiotics are aliphatic, with their hydrophobic components interacting with the bacterial cell membrane. antibiotic_resistance ARO:3000035 lipopeptide antibiotic ARO:3000035 Lipopeptide antibiotics are aliphatic, with their hydrophobic components interacting with the bacterial cell membrane. PMID:19156787 Enzymes or other gene products which hydroxylate tetracycline and other tetracycline derivatives. Hydroxylation inactivates tetracycline-like antibiotics, thus conferring resistance to these compounds. antibiotic_resistance ARO:3000036 tetracycline inactivation enzyme ARO:3000036 Enzymes or other gene products which hydroxylate tetracycline and other tetracycline derivatives. Hydroxylation inactivates tetracycline-like antibiotics, thus conferring resistance to these compounds. PMID:24497223 Hydrolysis of an antibiotic molecule to confer resistance. antibiotic_resistance ARO:3000040 hydrolysis of antibiotic conferring resistance ARO:3000040 Antibiotic adjuvants shown to inhibit the action of a beta-lactamase enzyme or enhance the ability of a beta-lactam antibiotic. These compounds are used along with antibiotics to treat beta-lactam-resistant infectious pathogens. antibiotic_resistance ARO:3000042 beta-lactamase inhibitor ARO:3000042 VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. antibiotic_resistance ARO:3000043 VEB beta-lactamase ARO:3000043 VEB beta-lactamases or Vietnamese extended-spectrum beta-lactamases are class A beta-lactamases that confer high-level resistance to oxyimino cephalosporins and to aztreonam. PMID:10049269 A collection of curated phenotypic terms relating to antibiotic resistance and the Comprehensive Antibiotic Resistance Database. antibiotic_resistance ARO:3000045 component of AMR genotypic or phenotypic terminology ARO:3000045 These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes. antibiotic_resistance ARO:3000050 tetracycline antibiotic ARO:3000050 These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes. PMID:11381101 Peptide antibiotics have a wide range of antibacterial mechanisms, depending on the amino acids that make up the antibiotic, although most act to disrupt the cell membrane in some manner. Subclasses of peptide antibiotics can include additional sidechains of other types, such as lipids in the case of the lipopeptide antibiotics. antibiotic_resistance ARO:3000053 peptide antibiotic ARO:3000053 Peptide antibiotics have a wide range of antibacterial mechanisms, depending on the amino acids that make up the antibiotic, although most act to disrupt the cell membrane in some manner. Subclasses of peptide antibiotics can include additional sidechains of other types, such as lipids in the case of the lipopeptide antibiotics. PMID:10348745 PMID:18065456 SME beta-lactamases are chromosome-mediated class A beta-lactamases that hydrolyze carbapenems in Serratia marcescens. antibiotic_resistance ARO:3000055 SME beta-lactamase ARO:3000055 SME beta-lactamases are chromosome-mediated class A beta-lactamases that hydrolyze carbapenems in Serratia marcescens. PMID:8092824 PER beta-lactamases are plasmid-mediated extended spectrum beta-lactamases found in the Enterobacteriaceae family. antibiotic_resistance ARO:3000056 PER beta-lactamase ARO:3000056 NDM beta-lactamases or New Delhi metallo-beta-lactamases are class B beta-lactamases that confer resistance to a broad range of antibiotics including carbapenems, cephalosporins and penicillins. antibiotic_resistance ARO:3000057 NDM beta-lactamase ARO:3000057 NDM beta-lactamases or New Delhi metallo-beta-lactamases are class B beta-lactamases that confer resistance to a broad range of antibiotics including carbapenems, cephalosporins and penicillins. PMID:19770275 PMID:20705517 PMID:21393184 PMID:21507902 PMID:21624908 PMID:21930874 PMID:22078325 PMID:24165671 MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams. antibiotic_resistance ARO:3000058 MIR beta-lactamase ARO:3000058 MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams. PMID:1963529 Klebsiella pneumoniae carbapenem resistant (KPC) beta-lactamases are notorious for their ability to efficiently hydrolyze carbapenems, unlike other Ambler Class A beta-lactamases. There are currently 9 variants reported worldwide. These enzymes were first isolated from Klebsiella pneumoniae strains in 2001 in the United States. Hospital outbreaks have since been reported in Greece and Israel and KPC carrying strains are now endemic to New York facilities. KPC-1 and KPC-2 have been shown to be identical and are now referred to as KPC-2. antibiotic_resistance ARO:3000059 KPC beta-lactamase ARO:3000059 Klebsiella pneumoniae carbapenem resistant (KPC) beta-lactamases are notorious for their ability to efficiently hydrolyze carbapenems, unlike other Ambler Class A beta-lactamases. There are currently 9 variants reported worldwide. These enzymes were first isolated from Klebsiella pneumoniae strains in 2001 in the United States. Hospital outbreaks have since been reported in Greece and Israel and KPC carrying strains are now endemic to New York facilities. KPC-1 and KPC-2 have been shown to be identical and are now referred to as KPC-2. PMID:17441734 PMID:19493866 IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases. antibiotic_resistance ARO:3000060 IND beta-lactamase ARO:3000060 IND beta-lactamases are class B carbapenem-hydrolyzing beta-lactamases. PMID:10077836 GES beta-lactamases or Guiana extended-spectrum beta-lactamases are related to the other plasmid-located class A beta-lactamases. antibiotic_resistance ARO:3000066 GES beta-lactamase ARO:3000066 FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins. antibiotic_resistance ARO:3000067 FOX beta-lactamase ARO:3000067 FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins. PMID:7811034 DHA beta-lactamases are plasmid-mediated AmpC β-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins. antibiotic_resistance ARO:3000068 DHA beta-lactamase ARO:3000068 DHA beta-lactamases are plasmid-mediated AmpC β-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins. PMID:9736562 CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins. antibiotic_resistance ARO:3000069 CMY beta-lactamase ARO:3000069 VanS is similar to histidine protein kinases like EnvZ and acts as a response regulator by activating VanR. VanS is required for high level transcription of other van glycopeptide resistance genes. antibiotic_resistance ARO:3000071 vanS ARO:3000071 VanS is similar to histidine protein kinases like EnvZ and acts as a response regulator by activating VanR. VanS is required for high level transcription of other van glycopeptide resistance genes. PMID:1556077 ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae. antibiotic_resistance ARO:3000072 ACT beta-lactamase ARO:3000072 ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae. PMID:9055993 ACC beta-lactamases or Ambler class C beta-lactamases are AmpC beta-lactamases. They possess an interesting resistance phenotype due to their low activity against cephamycins. antibiotic_resistance ARO:3000073 ACC beta-lactamase ARO:3000073 ACC beta-lactamases or Ambler class C beta-lactamases are AmpC beta-lactamases. They possess an interesting resistance phenotype due to their low activity against cephamycins. PMID:10428914 emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP), nalidixic acid, and thioloactomycin. emrB antibiotic_resistance ARO:3000074 emrB ARO:3000074 emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP), nalidixic acid, and thioloactomycin. PMID:1409590 emrB Class D beta-lactamases are one of the subgroups of beta-lactamases that are classified as serine enzymes. antibiotic_resistance ARO:3000075 class D beta-lactamase ARO:3000075 AmpC type beta-lactamases are commonly isolated from extended-spectrum cephalosporin-resistant Gram-negative bacteria. AmpC beta-lactamases (also termed class C or group 1) are typically encoded on the chromosome of many Gram-negative bacteria including Citrobacter, Serratia, Enterobacter species, and P. aeruginosa where its expression is usually inducible; it may also occur on Escherichia coli but is not usually inducible, although it can be hyperexpressed. AmpC type beta-lactamases may also be carried on plasmids. AmpC beta-lactamases, in contrast to ESBLs, hydrolyse broad and extended-spectrum cephalosporins (cephamycins as well as to oxyimino-beta-lactams) but are not inhibited by beta-lactamase inhibitors such as clavulanic acid. AmpC beta-lactamase antibiotic_resistance ARO:3000076 class C beta-lactamase ARO:3000076 AmpC type beta-lactamases are commonly isolated from extended-spectrum cephalosporin-resistant Gram-negative bacteria. AmpC beta-lactamases (also termed class C or group 1) are typically encoded on the chromosome of many Gram-negative bacteria including Citrobacter, Serratia, Enterobacter species, and P. aeruginosa where its expression is usually inducible; it may also occur on Escherichia coli but is not usually inducible, although it can be hyperexpressed. AmpC type beta-lactamases may also be carried on plasmids. AmpC beta-lactamases, in contrast to ESBLs, hydrolyse broad and extended-spectrum cephalosporins (cephamycins as well as to oxyimino-beta-lactams) but are not inhibited by beta-lactamase inhibitors such as clavulanic acid. PMID:19822890 VanY is a D,D-carboxypeptidase that cleaves removes the terminal D-Ala from peptidoglycan for the addition of D-Lactate. The D-Ala-D-Lac peptidoglycan subunits have reduced binding affinity with vancomycin compared to D-Ala-D-Ala. antibiotic_resistance ARO:3000077 vanY ARO:3000077 VanY is a D,D-carboxypeptidase that cleaves removes the terminal D-Ala from peptidoglycan for the addition of D-Lactate. The D-Ala-D-Lac peptidoglycan subunits have reduced binding affinity with vancomycin compared to D-Ala-D-Ala. PMID:16323116 PMID:24711382 The Class A beta-lactamases are one of the subgroups of beta-lactamases that are classified as serine enzymes. Class A beta-lactamases exhibit a large degree of variability and are known to hydrolyze penicillins. antibiotic_resistance ARO:3000078 class A beta-lactamase ARO:3000078 The Class A beta-lactamases are one of the subgroups of beta-lactamases that are classified as serine enzymes. Class A beta-lactamases exhibit a large degree of variability and are known to hydrolyze penicillins. PMID:17407578 Oxazolidinones are a class of synthetic antibiotics discovered the the 1980's. They inhibit protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes. Linezolid is the only member of this class currently in clinical use. antibiotic_resistance ARO:3000079 oxazolidinone antibiotic ARO:3000079 Oxazolidinones are a class of synthetic antibiotics discovered the the 1980's. They inhibit protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes. Linezolid is the only member of this class currently in clinical use. PMID:18757750 Aminonucleoside antibiotics are nucleoside antibiotics that contain an amino group. This amino group is often acylated, e.g. puromycin. antibiotic_resistance ARO:3000080 aminonucleoside antibiotic ARO:3000080 Aminonucleoside antibiotics are nucleoside antibiotics that contain an amino group. This amino group is often acylated, e.g. puromycin. PMID:8576156 Glycopeptide antibiotics are natural products produced non-ribosomally by Actinomycetales bacteria. With the exception of bleomycins, they act by binding the terminal D-Ala-D-Ala in peptidoglycan precursors of the growing bacterial cell wall and are generally active against Gram-positive bacteria. This inhibits transglycosylation leading to cell death due to osmotic stress. antibiotic_resistance ARO:3000081 glycopeptide antibiotic ARO:3000081 Glycopeptide antibiotics are natural products produced non-ribosomally by Actinomycetales bacteria. With the exception of bleomycins, they act by binding the terminal D-Ala-D-Ala in peptidoglycan precursors of the growing bacterial cell wall and are generally active against Gram-positive bacteria. This inhibits transglycosylation leading to cell death due to osmotic stress. PMID:10232990 PMID:16007453 PMID:3276316 PMID:4369274 The biological synthesis of antibiotics. antibiotic_resistance ARO:3000082 antibiotic biosynthesis ARO:3000082 MOX beta-lactamases are plasmid-mediated AmpC-type beta-lactamases. antibiotic_resistance ARO:3000083 MOX beta-lactamase ARO:3000083 A grouping of the related CMY, LAT, and MOX beta-lactamases. antibiotic_resistance ARO:3000085 CMY-LAT-MOX beta-lactamase ARO:3000085 A grouping of the related CMY and LAT beta-lactamases. antibiotic_resistance ARO:3000086 CMY-LAT beta-lactamase ARO:3000086 A grouping of the related CMY and MOX beta-lactamases. antibiotic_resistance ARO:3000087 CMY-MOX beta-lactamase ARO:3000087 AER beta-lactamases are capable of hydrolyzing arbenicillin. AsbB1 antibiotic_resistance ARO:3000089 AER beta-lactamase ARO:3000089 AER beta-lactamases are capable of hydrolyzing arbenicillin. PMID:9687391 Bla1 is a chromosomal-encoded beta-lactamase, found in Bacillus anthracis, which hydrolyzes penicillins. Bla1 antibiotic_resistance ARO:3000090 Bla1 ARO:3000090 Bla1 is a chromosomal-encoded beta-lactamase, found in Bacillus anthracis, which hydrolyzes penicillins. PMID:12760895 PMID:27557855 Bla1 CARB beta-lactamases are class A lactamases that can hydrolyze carbenicillin. Many of the PSE beta-lactamases have been renamed as CARB-lactamases with the notable exception of PSE-2 which is now OXA-10. antibiotic_resistance ARO:3000091 CARB beta-lactamase ARO:3000091 CARB beta-lactamases are class A lactamases that can hydrolyze carbenicillin. Many of the PSE beta-lactamases have been renamed as CARB-lactamases with the notable exception of PSE-2 which is now OXA-10. PMID:6782068 PMID:9687391 OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. antibiotic_resistance ARO:3000094 OCH beta-lactamase ARO:3000094 OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. PMID:11451692 SRT beta-lactamases. antibiotic_resistance ARO:3000095 SRT beta-lactamase ARO:3000095 A grouping of the related SHV and LEN beta-lactamases. antibiotic_resistance ARO:3000096 SHV-LEN beta-lactamase ARO:3000096 LEN beta-lactamases are chromosomal class A beta-lactamases that confer resistance to ampicillin, amoxicillin, carbenicillin, and ticarcillin but not to extended-spectrum beta-lactams. antibiotic_resistance ARO:3000097 LEN beta-lactamase ARO:3000097 LEN beta-lactamases are chromosomal class A beta-lactamases that confer resistance to ampicillin, amoxicillin, carbenicillin, and ticarcillin but not to extended-spectrum beta-lactams. PMID:15215087 PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa. antibiotic_resistance ARO:3000098 PDC beta-lactamase ARO:3000098 PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa. PMID:19258272 Genes that directly or indirectly modulate beta-lactam resistance. antibiotic_resistance ARO:3000100 gene modulating beta-lactam resistance ARO:3000100 Genes that directly or indirectly modulate beta-lactam resistance. PMID:16143832 Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling. antibiotic_resistance ARO:3000103 aminocoumarin antibiotic ARO:3000103 Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling. PMID:8231802 Phosphorylation of antibiotic usually by ATP, sometimes GTP. antibiotic_resistance ARO:3000105 phosphorylation of antibiotic conferring resistance ARO:3000105 Addition of an acyl group to an antibiotic, often via acetylation by acetylCoA. antibiotic_resistance ARO:3000106 acylation of antibiotic conferring resistance ARO:3000106 Modification by NMP, usually AMP. antibiotic_resistance ARO:3000107 nucleotidylation of antibiotic conferring resistance ARO:3000107 Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling. CAS:303-81-1 ChEBI:28368 ChEMBL:CHEMBL36506 PubChem:54675769 cathomycin streptonivicin antibiotic_resistance ARO:3000111 novobiocin ARO:3000111 Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling. PMID:10770754 PMID:4680802 PMID:8231802 Directed pumping of antibiotic out of a cell to confer resistance. Multidrug and toxic compound extrusion (MATE) transporters utilize the cationic gradient across the membrane as an energy source. Although there is a diverse substrate specificity, almost all MATE transporters recognize fluoroquinolones. Arciflavine, ethidium and aminoglycosides are also good substrates. antibiotic_resistance ARO:3000112 multidrug and toxic compound extrusion (MATE) transporter ARO:3000112 Directed pumping of antibiotic out of a cell to confer resistance. Multidrug and toxic compound extrusion (MATE) transporters utilize the cationic gradient across the membrane as an energy source. Although there is a diverse substrate specificity, almost all MATE transporters recognize fluoroquinolones. Arciflavine, ethidium and aminoglycosides are also good substrates. PMID:16330770 PMID:19100867 Vga-type plasmid-borne ABC-F proteins, expressed in staphylococci that confer resistance to streptogramin A antibiotics through ribosomal protection. antibiotic_resistance ARO:3000113 vga-type ABC-F protein ARO:3000113 Vga-type plasmid-borne ABC-F proteins, expressed in staphylococci that confer resistance to streptogramin A antibiotics through ribosomal protection. PMID:15728891 PMID:20876620 PMID:21768510 Kinases that modify aminoglycoside antibiotics by phosphorylation using NTPs as cofactor. aminoglycoside kinase antibiotic_resistance ARO:3000114 aminoglycoside phosphotransferase (APH) ARO:3000114 Kinases that modify aminoglycoside antibiotics by phosphorylation using NTPs as cofactor. PMID:20833577 PMID:9872733 ParE is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Mutations in ParE prevents antibiotics from inhibiting DNA synthesis, thus conferring resistance. antibiotic_resistance ARO:3000115 antibiotic resistant DNA topoisomerase subunit parE ARO:3000115 VanZ is a teicoplanin resistance gene that is an accessory protein. VanZ prevents the incorporation of the terminal D-Ala into peptidoglycan subunits. antibiotic_resistance ARO:3000116 vanZ ARO:3000116 VanZ is a teicoplanin resistance gene that is an accessory protein. VanZ prevents the incorporation of the terminal D-Ala into peptidoglycan subunits. PMID:16323116 A47934 is an 'aglycone' glycopeptide antibiotic produced by Streptomyces toyocaensis. It is a teicoplanin-like glycopeptide. CAS:90039-80-8 ChEBI:29505 PubChem:16131155 antibiotic_resistance ARO:3000117 antibiotic A47934 ARO:3000117 A47934 is an 'aglycone' glycopeptide antibiotic produced by Streptomyces toyocaensis. It is a teicoplanin-like glycopeptide. PMID:12060705 PMID:16492565 PMID:17884639 PMID:9435111 Vga(B) is an ABC-F protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA. vgaB antibiotic_resistance ARO:3000118 vgaB ARO:3000118 Vga(B) is an ABC-F protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA. PMID:15728891 PMID:9427556 vgaB Edeines are basic linear peptides produced by Bacillus brevis Vm4. They have antibacterial as well as antifungal, antiviral, and anticancer properties. Edeines are bacteriostatic and bacteriocidal at low and high concentrations, respectively. They are able to inhibit DNA synthesis and protein translation. These compounds are synthesized by nonribosomal peptide synthetases and contain numerous unusual amino acids. antibiotic_resistance ARO:3000119 edeine ARO:3000119 Edeines are basic linear peptides produced by Bacillus brevis Vm4. They have antibacterial as well as antifungal, antiviral, and anticancer properties. Edeines are bacteriostatic and bacteriocidal at low and high concentrations, respectively. They are able to inhibit DNA synthesis and protein translation. These compounds are synthesized by nonribosomal peptide synthetases and contain numerous unusual amino acids. PMID:70202 Balhimycin is a vancomycin-like glycopeptide antibiotic produced by Amycolatopsis balhimycina. It binds to the terminal Lys-D-Ala-D-Ala of peptidoglycan precursors. PubChem:16134543 antibiotic_resistance ARO:3000120 balhimycin ARO:3000120 Balhimycin is a vancomycin-like glycopeptide antibiotic produced by Amycolatopsis balhimycina. It binds to the terminal Lys-D-Ala-D-Ala of peptidoglycan precursors. PMID:10390204 PMID:11495926 PMID:11932455 PMID:16730832 PMID:9761883 Aminoglycoside acetyltransferase enzymes modify aminoglycoside antibiotics by catalyzing the transfer of an acetyl group to one of the amino groups present in aminoglycosides, using acetyl coenzyme A as a donor substrate. aminoglycoside N-acetyltransferase antibiotic_resistance ARO:3000121 aminoglycoside acetyltransferase (AAC) ARO:3000121 Aminoglycoside acetyltransferase enzymes modify aminoglycoside antibiotics by catalyzing the transfer of an acetyl group to one of the amino groups present in aminoglycosides, using acetyl coenzyme A as a donor substrate. PMID:20833577 Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. antibiotic_resistance ARO:3000122 chloramphenicol acetyltransferase (CAT) ARO:3000122 Inactivates chloramphenicol by addition of an acyl group. CAT is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum, Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. PMID:11553538 PMID:11677608 PMID:11735367 PMID:11743194 PMID:12603745 PMID:12650243 PMID:12726767 PMID:12732947 PMID:1406372 PMID:1461942 PMID:1517170 PMID:15539072 PMID:1650008 PMID:1713259 PMID:1929282 PMID:1929326 PMID:19459958 PMID:2013403 PMID:2227449 PMID:2697637 PMID:2993795 PMID:3110008 PMID:3860383 PMID:3865770 PMID:3900035 PMID:6950931 PMID:9349809 Gramicidins are a family of antibiotics synthesized by Bacillus brevis. It includes the linear pentadecapeptides gramicidin A, B and C that make up the mixture gramicidin D. Gramicidin S is a cyclic peptide chain. Gramicidins are also components of tyrothricins, another mixture of antibiotics produced by Bacillus brevis. PubChem:16130140 antibiotic_resistance ARO:3000123 gramicidin ARO:3000123 mecI acts as a repressor of transcription of the mecA/mecR1/mecI operon. mecI antibiotic_resistance ARO:3000124 mecI ARO:3000124 mecI acts as a repressor of transcription of the mecA/mecR1/mecI operon. PMID:24564530 mecI The use of different nucleophilic molecules by enzymes can break up the epoxide ring of fosfomycin and render the molecule ineffective. antibiotic_resistance ARO:3000125 hydrolysis of fosfomycin epoxide ring ARO:3000125 A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 3'-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically kanamycin and neomycin, by the ATP-dependent phosphorylation of the 3'-hydroxyl group of the compound. antibiotic_resistance ARO:3000126 APH(3') ARO:3000126 A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 3'-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically kanamycin and neomycin, by the ATP-dependent phosphorylation of the 3'-hydroxyl group of the compound. PMID:8385262 PMID:9200607 A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of streptomycin, by the ATP-dependent phosphorylation of the 3''-hydroxyl group of the compound. antibiotic_resistance ARO:3000127 APH(3'') ARO:3000127 A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 2''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically kanamycin, tobramycin and amikacin, by the ATP-dependent phosphorylation of the 3'-hydroxyl group of the compound. antibiotic_resistance ARO:3000128 APH(2'') ARO:3000128 Edeine A is a subtype of the peptide antibiotic edeine, composed of beta-tyr, beta-ser, diaminopropionic acid, diaminohydroxyazelaic acid, glycine, and spermidine. Edeine A is a mixture of edeine A1 and its inactive isomer, edeine A2. Edeines bind to the 30S subunit to block fMet-tRNA interaction at the P site, inhibiting protein synthesis and subsequent structure/function processes critical for life or replication. PubChem:379085 antibiotic_resistance ARO:3000130 edeine A ARO:3000130 Edeine A is a subtype of the peptide antibiotic edeine, composed of beta-tyr, beta-ser, diaminopropionic acid, diaminohydroxyazelaic acid, glycine, and spermidine. Edeine A is a mixture of edeine A1 and its inactive isomer, edeine A2. Edeines bind to the 30S subunit to block fMet-tRNA interaction at the P site, inhibiting protein synthesis and subsequent structure/function processes critical for life or replication. PMID:14731399 PMID:4984939 PMID:70202 Clorobiocin is an aminocoumarin antibiotic produced by Streptomyces roseochromogenes, and binds DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling. ChEMBL:CHEMBL303984 PubChem:54706138 antibiotic_resistance ARO:3000132 clorobiocin ARO:3000132 Clorobiocin is an aminocoumarin antibiotic produced by Streptomyces roseochromogenes, and binds DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling. PMID:12044152 PMID:6154685 PMID:8231802 Catalyzes the addition of a thiol group from a nucleophilic molecule to fosfomycin. antibiotic_resistance ARO:3000133 fosfomycin thiol transferase ARO:3000133 Edeine B is a subtype of the peptide antibiotic edeine, composed of beta-tyr, beta-ser, diaminopropionic acid, diaminohydroxyazelaic acid, glycine, and guanylspermidine. Edeine B is a mixture of edeine B1 and its inactive isomer, edeine B2. Edeines bind to the 30S subunit to block fMet-tRNA interaction at the P site, inhibiting protein synthesis and subsequent structure/function processes critical for life or replication. Edeine B has also been shown to inhibit septation and cause filamentous morphology, also leading to cell death. PubChem:446232 antibiotic_resistance ARO:3000134 edeine B ARO:3000134 Edeine B is a subtype of the peptide antibiotic edeine, composed of beta-tyr, beta-ser, diaminopropionic acid, diaminohydroxyazelaic acid, glycine, and guanylspermidine. Edeine B is a mixture of edeine B1 and its inactive isomer, edeine B2. Edeines bind to the 30S subunit to block fMet-tRNA interaction at the P site, inhibiting protein synthesis and subsequent structure/function processes critical for life or replication. Edeine B has also been shown to inhibit septation and cause filamentous morphology, also leading to cell death. PMID:20410587 PMID:4984939 PMID:70202 Edeine D is a subtype of edeine similar to edeine A with the beta-tyr replaced by beta-phe-beta-ala. Edeines bind to the 30S subunit to block fMet-tRNA interaction at the P site, inhibiting protein synthesis and subsequent structure/function processes critical for life or replication. PubChem:170400 antibiotic_resistance ARO:3000135 edeine D ARO:3000135 Edeine D is a subtype of edeine similar to edeine A with the beta-tyr replaced by beta-phe-beta-ala. Edeines bind to the 30S subunit to block fMet-tRNA interaction at the P site, inhibiting protein synthesis and subsequent structure/function processes critical for life or replication. PMID:70202 Edeine F is a subtype of edeine similar to edeine B with beta-tyr replaced by beta-phe-beta-ala. Edeines bind to the 30S subunit to block fMet-tRNA interaction at the P site, inhibiting protein synthesis and subsequent structure/function processes critical for life or replication. PubChem:194407 antibiotic_resistance ARO:3000136 edeine F ARO:3000136 Edeine F is a subtype of edeine similar to edeine B with beta-tyr replaced by beta-phe-beta-ala. Edeines bind to the 30S subunit to block fMet-tRNA interaction at the P site, inhibiting protein synthesis and subsequent structure/function processes critical for life or replication. PMID:6615592 Tylosin is a 16-membered macrolide, naturally produced by Streptomyces fradiae. It interacts with the bacterial ribosome 50S subunit to inhibit protein synthesis. CAS:1401-69-0 ChEBI:17658 ChEMBL:CHEMBL42743 PubChem:5280440 antibiotic_resistance ARO:3000145 tylosin ARO:3000145 Tylosin is a 16-membered macrolide, naturally produced by Streptomyces fradiae. It interacts with the bacterial ribosome 50S subunit to inhibit protein synthesis. PMID:19793461 An enzyme that confers resistance to fosfomycin in Serratia marcescens by breaking the epoxide ring of the molecule. It depends on the cofactors Manganese (II) and Potassium and uses Glutathione (GSH) as the nucleophilic molecule. In Pseudomonas aeruginosa, FosA catalyzes the conjugation of glutathione to carbon-1 of fosfomycin, rendering it ineffective as an antibacterial drug. PDB:1NPB FosA antibiotic_resistance ARO:3000149 FosA ARO:3000149 An enzyme that confers resistance to fosfomycin in Serratia marcescens by breaking the epoxide ring of the molecule. It depends on the cofactors Manganese (II) and Potassium and uses Glutathione (GSH) as the nucleophilic molecule. In Pseudomonas aeruginosa, FosA catalyzes the conjugation of glutathione to carbon-1 of fosfomycin, rendering it ineffective as an antibacterial drug. PMID:15075406 PMID:15741169 FosA Coumermycin A1 is an antibiotic produced by Streptomyces rishiriensis, and binds DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling. CAS:4434-05-3 ChEBI:3907 ChEMBL:CHEMBL389471 PubChem:54675768 Notomycin A1 antibiotic_resistance ARO:3000150 coumermycin A1 ARO:3000150 Coumermycin A1 is an antibiotic produced by Streptomyces rishiriensis, and binds DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling. PMID:11036020 PMID:14285468 PMID:14285469 PMID:8231802 A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 6-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of streptomycin, by the ATP-dependent phosphorylation of the 6-hydroxyl group of the compound. antibiotic_resistance ARO:3000151 APH(6) ARO:3000151 Minocycline is second generation semi-synthetic derivative of the tetracycline group of antibiotics. It inhibits bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome and preventing the aminotransferase-tRNA from associating with the ribosome. CAS:10118-90-8 ChEBI:50694 ChEMBL:CHEMBL1434 PubChem:54675783 antibiotic_resistance ARO:3000152 minocycline ARO:3000152 Minocycline is second generation semi-synthetic derivative of the tetracycline group of antibiotics. It inhibits bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome and preventing the aminotransferase-tRNA from associating with the ribosome. PMID:11381101 PMID:19862477 A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 9-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of spectinomycin, by the ATP-dependent phosphorylation of the 9-hydroxyl group of the compound. antibiotic_resistance ARO:3000153 APH(9) ARO:3000153 A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 9-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of spectinomycin, by the ATP-dependent phosphorylation of the 9-hydroxyl group of the compound. PMID:20089863 PMID:9614079 A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 7''-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of hygromycin, by the ATP-dependent phosphorylation of the 7''-hydroxyl group of the compound. antibiotic_resistance ARO:3000154 APH(7'') ARO:3000154 A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 4-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of hygromycin, by the ATP-dependent phosphorylation of the 4-hydroxyl group of the compound. antibiotic_resistance ARO:3000155 APH(4) ARO:3000155 A category of aminoglycoside O-phosphotransferase enzymes with modification regiospecificity based at the 4-hydroxyl group of the respective antibiotic. These enzymes are characterized by enzymatic antibiotic inactivation, specifically of hygromycin, by the ATP-dependent phosphorylation of the 4-hydroxyl group of the compound. PMID:21084294 Spiramycin is a 16-membered macrolide and is natural product produced by Streptomyces ambofaciens. It binds to the 50S subunit of bacterial ribosomes and inhibits peptidyl transfer activity to disrupt protein synthesis. CAS:24916-50-5 ChEBI:85260 ChEMBL:CHEMBL453514 PubChem:6419898 rovamycin antibiotic_resistance ARO:3000156 spiramycin ARO:3000156 Spiramycin is a 16-membered macrolide and is natural product produced by Streptomyces ambofaciens. It binds to the 50S subunit of bacterial ribosomes and inhibits peptidyl transfer activity to disrupt protein synthesis. PMID:7683018 Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs. antibiotic_resistance ARO:3000157 rifamycin antibiotic ARO:3000157 Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs. PMID:15700959 Azithromycin is a 15-membered macrolide and falls under the subclass of azalide. Like other macrolides, azithromycin binds bacterial ribosomes to inhibit protein synthesis. The nitrogen substitution at the C-9a position prevents its degradation. CAS:83905-01-5 ChEBI:2955 ChEMBL:CHEMBL529 PubChem:447043 AZM antibiotic_resistance ARO:3000158 azithromycin ARO:3000158 Azithromycin is a 15-membered macrolide and falls under the subclass of azalide. Like other macrolides, azithromycin binds bacterial ribosomes to inhibit protein synthesis. The nitrogen substitution at the C-9a position prevents its degradation. PMID:1662624 Efflux proteins that pump antibiotic out of a cell to confer resistance. antibiotic_resistance ARO:3000159 efflux pump complex or subunit conferring antibiotic resistance ARO:3000159 blaI acts as a repressor of transcription of the blaZ/blaR1/blaI operon. blaI antibiotic_resistance ARO:3000160 blaI ARO:3000160 blaI acts as a repressor of transcription of the blaZ/blaR1/blaI operon. PMID:12654668 blaI Catalyzes methylation of rRNA. antibiotic_resistance ARO:3000164 rRNA methyltransferase conferring antibiotic resistance ARO:3000164 Catalyzes methylation of rRNA. PMID:1929280 TetA is a tetracycline efflux pump found in many species of Gram-negative bacteria. tet(A) tetA antibiotic_resistance ARO:3000165 tet(A) ARO:3000165 TetA is a tetracycline efflux pump found in many species of Gram-negative bacteria. PMID:15837373 PMID:8821947 tet(A) Tet(B) is a tetracycline efflux protein expressed in many Gram-negative bacteria. It confers resistance to tetracycline, doxycycline, and minocycline, but not tigecycline. tet(B) tetB antibiotic_resistance ARO:3000166 tet(B) ARO:3000166 Tet(B) is a tetracycline efflux protein expressed in many Gram-negative bacteria. It confers resistance to tetracycline, doxycycline, and minocycline, but not tigecycline. PMID:15837373 tet(B) Tet(C) is a tetracycline efflux pump found in many species of Gram-negative bacteria. It is typically found in plasmid DNA. tet(C) tetC antibiotic_resistance ARO:3000167 tet(C) ARO:3000167 Tet(C) is a tetracycline efflux pump found in many species of Gram-negative bacteria. It is typically found in plasmid DNA. PMID:6307828 tet(C) TetD is a tetracycline efflux pump found exclusively in Gram-negative bacteria. tet(D) tetD antibiotic_resistance ARO:3000168 tet(D) ARO:3000168 TetD is a tetracycline efflux pump found exclusively in Gram-negative bacteria. PMID:15837373 tet(D) Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections. CAS:13292-46-1 ChEBI:28077 ChEMBL:CHEMBL374478 PubChem:135398735 rifampicin antibiotic_resistance ARO:3000169 rifampin ARO:3000169 Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections. PMID:15667909 PMID:6356275 Imipenem is a broad-spectrum antibiotic and is usually taken with cilastatin, which prevents hydrolysis of imipenem by renal dehydropeptidase-I. It is resistant to hydrolysis by most other beta-lactamases. Notable exceptions are the KPC beta-lactamases and Ambler Class B enzymes. CAS:64221-86-9 ChEBI:471744 ChEMBL:CHEMBL148 PubChem:104838 IMI antibiotic_resistance ARO:3000170 imipenem ARO:3000170 Imipenem is a broad-spectrum antibiotic and is usually taken with cilastatin, which prevents hydrolysis of imipenem by renal dehydropeptidase-I. It is resistant to hydrolysis by most other beta-lactamases. Notable exceptions are the KPC beta-lactamases and Ambler Class B enzymes. PMID:10629005 PMID:12084099 Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups. They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis. diaminopyrimidine antibiotic_resistance ARO:3000171 diaminopyrimidine antibiotic ARO:3000171 Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups. They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis. PMID:8195830 A thiol transferase that leads to the resistance of fosfomycin. Contrasting FosA, FosB is dependent on the cofactor Magnesium (II) and uses either bacillithiol or L-cysteine to open up the epoxide ring of fosfomycin. PDB:4JH1 FosB antibiotic_resistance ARO:3000172 FosB ARO:3000172 A thiol transferase that leads to the resistance of fosfomycin. Contrasting FosA, FosB is dependent on the cofactor Magnesium (II) and uses either bacillithiol or L-cysteine to open up the epoxide ring of fosfomycin. PMID:24004181 PMID:24447055 FosB TetE is a tetracycline efflux pump found in many Gram-negative bacteria, especially those in water environments. The gene is found on large plasmids. tet(E) tetE antibiotic_resistance ARO:3000173 tet(E) ARO:3000173 TetE is a tetracycline efflux pump found in many Gram-negative bacteria, especially those in water environments. The gene is found on large plasmids. PMID:15837373 tet(E) TetG is a tetracycline efflux protein found in Gram-negative bacteria. The encoding gene is found in both chromosomal and plasmid DNA where it is frequently linked to the floR, sul1, and cmlA9 genes which encode proteins that can confer florfenicol/chloramphenicol, sulfamethoxazole, and chloramphenicol resistance, respectively. tet(G) tetG antibiotic_resistance ARO:3000174 tet(G) ARO:3000174 TetG is a tetracycline efflux protein found in Gram-negative bacteria. The encoding gene is found in both chromosomal and plasmid DNA where it is frequently linked to the floR, sul1, and cmlA9 genes which encode proteins that can confer florfenicol/chloramphenicol, sulfamethoxazole, and chloramphenicol resistance, respectively. PMID:15837373 tet(G) TetH is a tetracycline efflux protein expressed in Gram-negative bacteria (Actinobacillus, Acinetobacter, Gallibacterium, Histophilus, Mannheimia, Moraxella, Pasteurella, and Psychrobacter). Its gene is linked to the resistance genes sul2, and strA, which confer resistance to sulfamethoxazole and streptomycin, respectively. tet(H) tetH antibiotic_resistance ARO:3000175 tet(H) ARO:3000175 TetH is a tetracycline efflux protein expressed in Gram-negative bacteria (Actinobacillus, Acinetobacter, Gallibacterium, Histophilus, Mannheimia, Moraxella, Pasteurella, and Psychrobacter). Its gene is linked to the resistance genes sul2, and strA, which confer resistance to sulfamethoxazole and streptomycin, respectively. PMID:15837373 tet(H) Dirithromycin is an oxazine derivative of erythromycin, sharing the 14-carbon macrolide ring. The antibiotic binds to the 50S subunit of the ribosome to inhibit bacterial protein synthesis. CAS:62013-04-1 ChEBI:474014 ChEMBL:CHEMBL1237072 PubChem:6473883 antibiotic_resistance ARO:3000176 dirithromycin ARO:3000176 Dirithromycin is an oxazine derivative of erythromycin, sharing the 14-carbon macrolide ring. The antibiotic binds to the 50S subunit of the ribosome to inhibit bacterial protein synthesis. PMID:7683018 TetJ is a tetracycline efflux protein expressed in Gram-negative bacteria (Escherichia, Morganella, and Proteus). tet(J) tetJ antibiotic_resistance ARO:3000177 tet(J) ARO:3000177 TetJ is a tetracycline efflux protein expressed in Gram-negative bacteria (Escherichia, Morganella, and Proteus). PMID:15837373 tet(J) TetK is a tetracycline efflux protein found in both Gram-negative (Haemophilus and Gallibacterium) and Gram-positive (many species, including mycobacteria) bacteria. tet(K) tetK antibiotic_resistance ARO:3000178 tet(K) ARO:3000178 TetK is a tetracycline efflux protein found in both Gram-negative (Haemophilus and Gallibacterium) and Gram-positive (many species, including mycobacteria) bacteria. PMID:15837373 PMID:7781778 PMID:8234490 tet(K) TetL is a tetracycline efflux protein found in many species of Gram-negative and Gram-positive bacteria. tet(L) tetL antibiotic_resistance ARO:3000179 tet(L) ARO:3000179 TetL is a tetracycline efflux protein found in many species of Gram-negative and Gram-positive bacteria. PMID:15837373 PMID:3324958 tet(L) TetA(P) is a inner membrane tetracycline efflux protein found on the same operon as the ribosomal protection protein TetB(P). It is found in Clostridium, a Gram-positive bacterium. tetA(P) tetP antibiotic_resistance ARO:3000180 tetA(P) ARO:3000180 TetA(P) is a inner membrane tetracycline efflux protein found on the same operon as the ribosomal protection protein TetB(P). It is found in Clostridium, a Gram-positive bacterium. PMID:14702405 PMID:15837373 tetA(P) TetV is a tetracycline efflux protein that has been found in Mycolicibacterium smegmatis and Mycolicibacterium fortuitum. tet(V) tetV antibiotic_resistance ARO:3000181 tet(V) ARO:3000181 TetV is a tetracycline efflux protein that has been found in Mycolicibacterium smegmatis and Mycolicibacterium fortuitum. PMID:15837373 PMID:22673307 PMID:9687386 tet(V) TetY is a tetracycline efflux pump found in Gram-negative bacteria (Aeromonas and Escherichia). It is associated with plasmid DNA. tet(Y) tetY antibiotic_resistance ARO:3000182 tet(Y) ARO:3000182 TetY is a tetracycline efflux pump found in Gram-negative bacteria (Aeromonas and Escherichia). It is associated with plasmid DNA. PMID:15837373 tet(Y) TetZ is a tetracycline efflux protein found in Gram-positive bacteria (Corynebacterium and Lactobacillus). It is associated with plasmid DNA. tet(Z) tetZ antibiotic_resistance ARO:3000183 tet(Z) ARO:3000183 TetZ is a tetracycline efflux protein found in Gram-positive bacteria (Corynebacterium and Lactobacillus). It is associated with plasmid DNA. PMID:15837373 tet(Z) Chloroeremomycin is a vancomycin-like glycopeptide, with three sugars instead of two in vancomycin and balhimycin. Chloroeremomycin dimerizes and binds to the terminus of peptidoglycan precursors. CAS:118395-73-6 ChEBI:29556 ChEMBL:CHEMBL1688951 PubChem:445806 antibiotic_resistance ARO:3000184 chloroeremomycin ARO:3000184 Chloroeremomycin is a vancomycin-like glycopeptide, with three sugars instead of two in vancomycin and balhimycin. Chloroeremomycin dimerizes and binds to the terminus of peptidoglycan precursors. PMID:11035791 PMID:11942828 PMID:9545426 These proteins confer antibiotic resistance by bind the antibiotic target to prevent antibiotic binding. antibiotic_resistance ARO:3000185 antibiotic target protection protein ARO:3000185 Tet(M) is a ribosomal protection protein that confers tetracycline resistance. It is found on transposable DNA elements and its horizontal transfer between bacterial species has been documented. tet(M) tetM antibiotic_resistance ARO:3000186 tet(M) ARO:3000186 Tet(M) is a ribosomal protection protein that confers tetracycline resistance. It is found on transposable DNA elements and its horizontal transfer between bacterial species has been documented. PMID:19475445 tet(M) Mechanism of enzymatic degradation common to Ambler Class A, C and D beta-lactamases. A serine residue located in the active site is used to form an acyl-enzyme intermediate and subsequent hydrolysis renders the beta-lactam inactive. antibiotic_resistance ARO:3000187 hydrolysis of beta-lactam antibiotic by serine beta-lactamase ARO:3000187 Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic. CAS:738-70-5 ChEBI:45924 ChEMBL:CHEMBL22 PubChem:5578 antibiotic_resistance ARO:3000188 trimethoprim ARO:3000188 Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic. PMID:11432417 PMID:18024520 Oritavancin is a semi-synthetic derivative of chloroeremomycin, a vancomycin-like glycopeptide. Oritavancin inhibits both transglycosylation and transpeptidation, by binding both the D-Ala-D-Ala and pentaglycine bridge segments of peptidoglycan to inhibit cell wall formation. CAS:171099-57-3 ChEBI:82699 ChEMBL:CHEMBL1688530 PubChem:16136912 antibiotic_resistance ARO:3000189 oritavancin ARO:3000189 Oritavancin is a semi-synthetic derivative of chloroeremomycin, a vancomycin-like glycopeptide. Oritavancin inhibits both transglycosylation and transpeptidation, by binding both the D-Ala-D-Ala and pentaglycine bridge segments of peptidoglycan to inhibit cell wall formation. PMID:15954849 PMID:18258256 PMID:27904526 Tet(O) is a ribosomal protection protein. It is associated with conjugative plasmids. tet(O) tetO antibiotic_resistance ARO:3000190 tet(O) ARO:3000190 Tet(O) is a ribosomal protection protein. It is associated with conjugative plasmids. PMID:2841293 PMID:9848445 tet(O) Tet(Q) is a ribosomal protection protein. Its gene is associated with a conjugative transposon and has been found in both Gram-positive and Gram-negative bacteria. tet(Q) tetA(Q) tetQ antibiotic_resistance ARO:3000191 tet(Q) ARO:3000191 Tet(Q) is a ribosomal protection protein. Its gene is associated with a conjugative transposon and has been found in both Gram-positive and Gram-negative bacteria. PMID:20826220 PMID:9372425 tet(Q) Tet(S) is a ribosomal protection protein found in Gram-positive and Gram-negative strains. It is similar to tet(M) and tet(O). tet(S) tetS antibiotic_resistance ARO:3000192 tet(S) ARO:3000192 Tet(S) is a ribosomal protection protein found in Gram-positive and Gram-negative strains. It is similar to tet(M) and tet(O). PMID:7840565 PMID:8370538 tet(S) Tet(T) is a ribosomal protection protein of streptococci. It is similar to Tet(Q). tet(T) tetT antibiotic_resistance ARO:3000193 tet(T) ARO:3000193 Tet(T) is a ribosomal protection protein of streptococci. It is similar to Tet(Q). PMID:8980765 tet(T) Tet(W) is a ribosomal protection protein. It is associated with both conjugative and non conjugative DNA and has been found strains of Clostridioides difficile. tet(W) tetW antibiotic_resistance ARO:3000194 tet(W) ARO:3000194 Tet(W) is a ribosomal protection protein. It is associated with both conjugative and non conjugative DNA and has been found strains of Clostridioides difficile. PMID:10681357 tet(W) TetB(P) is a tetracycline ribosomal protection protein found on the same operon as tetA(P), a tetracycline efflux protein. tetB(P) tetP antibiotic_resistance ARO:3000195 tetB(P) ARO:3000195 TetB(P) is a tetracycline ribosomal protection protein found on the same operon as tetA(P), a tetracycline efflux protein. PMID:15837373 tetB(P) Tet(32) is a tetracycline resistance gene similar to Tet(O), and binds to the ribosome to confer tetracycline resistance as a ribosomal protection protein. tet(32) tet32 antibiotic_resistance ARO:3000196 tet(32) ARO:3000196 Tet(32) is a tetracycline resistance gene similar to Tet(O), and binds to the ribosome to confer tetracycline resistance as a ribosomal protection protein. PMID:11600392 PMID:18955517 tet(32) Tet(36) is a tetracycline resistance gene found in Bacteroides similar to Tet(Q), and binds to the ribosome to confer antibiotic resistance as a ribosomal protection protein. tet(36) tet36 antibiotic_resistance ARO:3000197 tet(36) ARO:3000197 Tet(36) is a tetracycline resistance gene found in Bacteroides similar to Tet(Q), and binds to the ribosome to confer antibiotic resistance as a ribosomal protection protein. PMID:12839793 tet(36) FosX is an enzyme used to confer resistance to fosfomycin. It's dependent on the cofactor, manganese (II), and uses water to generate a vicinal diol. PDB:2P7K FosX antibiotic_resistance ARO:3000198 FosX ARO:3000198 FosX is an enzyme used to confer resistance to fosfomycin. It's dependent on the cofactor, manganese (II), and uses water to generate a vicinal diol. PMID:17567049 FosX Gramicidin D is a mixture of the linear peptides gramicidin A, B, and C, each with 15 alternating L- and D-amino acids. They are active against most gram-positive bacteria and select gram-negative bacteria. These compounds create channels in the bacterial membrane and increase the permeability to cations. PubChem:45267103 antibiotic_resistance ARO:3000199 gramicidin D ARO:3000199 Gramicidin D is a mixture of the linear peptides gramicidin A, B, and C, each with 15 alternating L- and D-amino acids. They are active against most gram-positive bacteria and select gram-negative bacteria. These compounds create channels in the bacterial membrane and increase the permeability to cations. PMID:17572379 PMID:9672588 Gramicidin S is a cyclical decapeptide with two pentapeptides (Val-Orn-Leu-D-Phe-Pro) joined head to tail. Like other gramicidins, Gramicidin S disrupts membrane permeability of cations while also destabilizing the membrane at higher concentrations. PubChem:73357 antibiotic_resistance ARO:3000200 gramicidin S ARO:3000200 Gramicidin S is a cyclical decapeptide with two pentapeptides (Val-Orn-Leu-D-Phe-Pro) joined head to tail. Like other gramicidins, Gramicidin S disrupts membrane permeability of cations while also destabilizing the membrane at higher concentrations. PMID:10590309 PMID:8836773 Enzymes shown to inactivate macrolide antibiotics by chemical modification, thereby conferring resistance to macrolides. antibiotic_resistance ARO:3000201 macrolide inactivation enzyme ARO:3000201 Cfr genes produce enzymes which catalyze the methylation of the 23S rRNA subunit at position 8 of adenine-2503. Methylation of 23S rRNA at this site confers resistance to some classes of antibiotics, including streptogramins, chloramphenicols, florfenicols, linezolids and clindamycin. antibiotic_resistance ARO:3000202 Cfr 23S ribosomal RNA methyltransferase ARO:3000202 Cfr genes produce enzymes which catalyze the methylation of the 23S rRNA subunit at position 8 of adenine-2503. Methylation of 23S rRNA at this site confers resistance to some classes of antibiotics, including streptogramins, chloramphenicols, florfenicols, linezolids and clindamycin. PMID:11476839 PMID:17555436 PMID:20144045 PMID:20598637 PMID:22547628 PMID:23752511 PMID:28663118 Mechanism of enzymatic degradation common to Ambler Class B beta-lactamases. One or two zinc atoms are used to orient a hydroxide nucleophile for attack of the beta-lactam ring. In contrast to serine beta-lactamases, no acyl-enzyme intermediate is formed. antibiotic_resistance ARO:3000203 hydrolysis of beta-lactam antibiotic by metallo-beta-lactamase ARO:3000203 Mechanism of enzymatic degradation common to Ambler Class B beta-lactamases. One or two zinc atoms are used to orient a hydroxide nucleophile for attack of the beta-lactam ring. In contrast to serine beta-lactamases, no acyl-enzyme intermediate is formed. PMID:20564281 Tet(X) is a flavin-dependent monooxygenase conferring resistance to tetracycline antibiotics. Tet(X) hydroxylates position 11a of the tetraketide group thus inactivating the antibiotic. PDB:2XYO tet(X) tetX antibiotic_resistance ARO:3000205 tet(X) ARO:3000205 Tet(X) is a flavin-dependent monooxygenase conferring resistance to tetracycline antibiotics. Tet(X) hydroxylates position 11a of the tetraketide group thus inactivating the antibiotic. PMID:15452119 PMID:16128584 PMID:1846135 PMID:21402075 tet(X) emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC, it mediates multidrug efflux. emrK antibiotic_resistance ARO:3000206 emrK ARO:3000206 emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC, it mediates multidrug efflux. PMID:12501312 emrK Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrA represents the periplasmic portion of the transport protein. antibiotic_resistance ARO:3000207 acrA ARO:3000207 Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrA represents the periplasmic portion of the transport protein. PMID:10931319 PMID:14706082 PMID:15226509 PMID:16531241 Addition of glycosyl moiety to antibiotics thereby inactivating them. antibiotic_resistance ARO:3000208 glycosylation of antibiotic conferring resistance ARO:3000208 ParY is part of a topoisomerase IV that is resistant to antibiotics that affect other topoisomerases. antibiotic_resistance ARO:3000209 antibiotic resistant DNA topoisomerase subunit parY ARO:3000209 Rifampin resistant RNA polymerases include amino acids substitutions which disrupt the affinity of rifampin for its binding site. These mutations are frequently concentrated in the rif I region of the beta-subunit and most often involve amino acids which make direct interactions with rifampin. However, mutations which also confer resistance can occur outside this region and may involve amino acids which do not directly make contact with rifampin. antibiotic_resistance ARO:3000210 rifamycin-resistant beta-subunit of RNA polymerase (rpoB) ARO:3000210 Rifampin resistant RNA polymerases include amino acids substitutions which disrupt the affinity of rifampin for its binding site. These mutations are frequently concentrated in the rif I region of the beta-subunit and most often involve amino acids which make direct interactions with rifampin. However, mutations which also confer resistance can occur outside this region and may involve amino acids which do not directly make contact with rifampin. PMID:10543773 PMID:11136757 PMID:12821473 PMID:15047531 PMID:21300839 PMID:22361457 PMID:3050121 Chemical alteration of the ribosome results in modification of an antibiotic's target leading to resistance. antibiotic_resistance ARO:3000211 ribosomal alteration conferring antibiotic resistance ARO:3000211 Point mutations in the DNA may lead to an altered gene product that may result in antibiotic resistance. Examples included modified antibiotic targets with lower binding affinities and the deactivation of repressors that result in increased expression of genes that inactivate or pump out antibiotics. antibiotic_resistance ARO:3000212 mutation conferring antibiotic resistance ARO:3000212 Peptidoglycan precursors ending in D-Ala-D-Lac or D-Ala-D-Ser instead of D-Ala-D-Ala conferring high level glycopeptide resistance. molecular bypass conferring antibiotic resistance antibiotic_resistance ARO:3000213 restructuring of bacterial cell wall conferring antibiotic resistance ARO:3000213 Peptidoglycan precursors ending in D-Ala-D-Lac or D-Ala-D-Ser instead of D-Ala-D-Ala conferring high level glycopeptide resistance. PMID:1931965 PMID:9177243 Hygromycin B is an aminoglycoside antibiotic used to treat different types of bacterial infections. Hygromycin B works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Hygromycin B has also been shown to interact with eukaryotic cells. CAS:31282-04-9 ChEBI:16976 PubChem:35766 antibiotic_resistance ARO:3000214 hygromycin B ARO:3000214 Hygromycin B is an aminoglycoside antibiotic used to treat different types of bacterial infections. Hygromycin B works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Hygromycin B has also been shown to interact with eukaryotic cells. PMID:10103173 PMID:11163189 mecR1 is a transmembrane spanning and signal transducing protein which in response to interaction with beta-lactam antibiotics results in upregulation of the mecA/mecR1/mecI operon. mecR1 antibiotic_resistance ARO:3000215 mecR1 ARO:3000215 mecR1 is a transmembrane spanning and signal transducing protein which in response to interaction with beta-lactam antibiotics results in upregulation of the mecA/mecR1/mecI operon. PMID:1544435 mecR1 Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrB functions as a herterotrimer which forms the inner membrane component and is primarily responsible for substrate recognition and energy transduction by acting as a drug/proton antiporter. PDB:1IWG ECK0456 JW0451 acrB antibiotic_resistance ARO:3000216 acrB ARO:3000216 Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrB functions as a herterotrimer which forms the inner membrane component and is primarily responsible for substrate recognition and energy transduction by acting as a drug/proton antiporter. PMID:12374972 PMID:17275331 PMID:18073115 PMID:19166984 PMID:19453279 acrB blaR1 is a transmembrane spanning and signal transducing protein which in response to interaction with beta-lactam antibiotics results in upregulation of the blaZ/blaR1/blaI operon. blaR1 antibiotic_resistance ARO:3000217 blaR1 ARO:3000217 blaR1 Covalent modification of aminoglycoside antibiotic hydroxyl group by ATP-dependent transfer of AMP. aminoglycoside adenyltransferase antibiotic_resistance ARO:3000218 aminoglycoside nucleotidyltransferase (ANT) ARO:3000218 Covalent modification of aminoglycoside antibiotic hydroxyl group by ATP-dependent transfer of AMP. PMID:20833577 Efflux regulatory proteins with mutations that result in increased expression of efflux proteins. antibiotic_resistance ARO:3000219 mutant efflux regulatory protein conferring antibiotic resistance ARO:3000219 Point mutations in gyrB confer antibiotic resistance by preventing drugs from binding the beta-subunit of gyrase, essential for DNA supercoiling. antibiotic_resistance ARO:3000220 antibiotic resistant DNA topoisomerase subunit gyrB ARO:3000220 Resistance to the lincosamide antibiotic by ATP-dependent modification of the 3' and/or 4'-hydroxyl groups of the methylthiolincosamide sugar. antibiotic_resistance ARO:3000221 lincosamide nucleotidyltransferase (LNU) ARO:3000221 Resistance to the lincosamide antibiotic by ATP-dependent modification of the 3' and/or 4'-hydroxyl groups of the methylthiolincosamide sugar. PMID:11797175 Gramicidin A is the most abundant (more than 80%) of the three gramicidins in gramicidin D, with a tryptophan in position 11. Gramicidins form dimers in the bacterial membrane that increase the permeability of cations. PubChem:16132269 antibiotic_resistance ARO:3000222 gramicidin A ARO:3000222 Gramicidin A is the most abundant (more than 80%) of the three gramicidins in gramicidin D, with a tryptophan in position 11. Gramicidins form dimers in the bacterial membrane that increase the permeability of cations. PMID:17572379 Gramicidin B is one of the three gramicidins in gramicidin D, with a phenylalanine in position 11. It is structurally similar to gramicidin A, but its ability to induce the assembly of bilayers is reduced. Gramicidins form dimers in the bacterial membrane that increase the permeability of cations. PubChem:25244501 antibiotic_resistance ARO:3000223 gramicidin B ARO:3000223 Gramicidin B is one of the three gramicidins in gramicidin D, with a phenylalanine in position 11. It is structurally similar to gramicidin A, but its ability to induce the assembly of bilayers is reduced. Gramicidins form dimers in the bacterial membrane that increase the permeability of cations. PMID:17572379 Gramicidin C is one of the three gramicidins in gramicidin D, with a tyrosine in position 11. It is structurally similar to gramicidin A, but its ability to induce the assembly of bilayers is reduced. Gramicidins form dimers in the bacterial membrane that increase the permeability of cations. PubChem:73357 antibiotic_resistance ARO:3000224 gramicidin C ARO:3000224 Gramicidin C is one of the three gramicidins in gramicidin D, with a tyrosine in position 11. It is structurally similar to gramicidin A, but its ability to induce the assembly of bilayers is reduced. Gramicidins form dimers in the bacterial membrane that increase the permeability of cations. PMID:17572379 A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 6-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically streptomycin, by transfer of an AMP group from an ATP substrate to the 6-hydroxyl group of the compound. antibiotic_resistance ARO:3000225 ANT(6) ARO:3000225 Point mutations in dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance. dihydropteroate synthase antibiotic_resistance ARO:3000226 antibiotic resistant folP ARO:3000226 Point mutations in dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance. PMID:1522070 PMID:21115799 PMID:9006040 PMID:9449266 PMID:9593127 Tyrothricin is a mixture of antibiotics including tyrocidines and gramicidins, isolated from Bacillus brevis. PubChem:452550 antibiotic_resistance ARO:3000227 tyrothricin ARO:3000227 Tyrothricin is a mixture of antibiotics including tyrocidines and gramicidins, isolated from Bacillus brevis. PMID:16560680 A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 9-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics, specifically streptomycin, by transfer of an AMP group from an ATP substrate to the 9-hydroxyl group of the compound. antibiotic_resistance ARO:3000228 ANT(9) ARO:3000228 A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 4'-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 4-hydroxyl group of the compound. aadD ant(4',4'') antibiotic_resistance ARO:3000229 ANT(4') ARO:3000229 Plasmid or integron-encoded nucleotidylylation of 2-deoxystreptamine aminoglycosides at the hydroxyl group at position 2'' in P. aeruginosa, K. pneumoniae, Morganella morganii, E. coli, S. typhimurium, C. freundii and A. baumannii. ANT(2'')-Ia aadB antibiotic_resistance ARO:3000230 ANT(2'')-Ia ARO:3000230 Plasmid or integron-encoded nucleotidylylation of 2-deoxystreptamine aminoglycosides at the hydroxyl group at position 2'' in P. aeruginosa, K. pneumoniae, Morganella morganii, E. coli, S. typhimurium, C. freundii and A. baumannii. PMID:25564464 PMID:3024112 ANT(2'')-Ia An operon conferring resistance to beta-lactam antibiotics. antibiotic_resistance ARO:3000231 beta-lactam resistance operon ARO:3000231 Nucleotidylylation of streptomycin at the hydroxyl group at position 3''. antibiotic_resistance ARO:3000232 ANT(3'')-Ia ARO:3000232 Resistance to streptogramin antibiotics may be conferred through enzymatic inactivation. There are two known mechanisms of streptogramin inactivation shown clinically to confer resistance: 1) vgB lyase enzymes linearize type B streptogramin antibiotics by breaking the ester linkage; 2) vat acetyltransferase enzymes modify type A streptogramin antibiotics by transferring an acetyl group from acetyl-CoA to the secondary streptogramin hydroxyl. Both mechanisms result in antibiotic inactivation thus conferring resistance. antibiotic_resistance ARO:3000233 streptogramin inactivation enzyme ARO:3000233 Resistance to streptogramin antibiotics may be conferred through enzymatic inactivation. There are two known mechanisms of streptogramin inactivation shown clinically to confer resistance: 1) vgB lyase enzymes linearize type B streptogramin antibiotics by breaking the ester linkage; 2) vat acetyltransferase enzymes modify type A streptogramin antibiotics by transferring an acetyl group from acetyl-CoA to the secondary streptogramin hydroxyl. Both mechanisms result in antibiotic inactivation thus conferring resistance. PMID:11467949 PMID:12771141 Genes that when expressed confer resistance to vancomycin and teicoplanin type antibiotics. antibiotic_resistance ARO:3000234 glycopeptide resistance gene cluster ARO:3000234 Genes that when expressed confer resistance to vancomycin and teicoplanin type antibiotics. PMID:16323116 embB gene encodes for an arabinosyl transferase in the arabinogalactan synthesis pathway. It is inhibited by ethambutol. Mutations within the ERDR region of embB confers resistance to ethambutol. antibiotic_resistance ARO:3000235 ethambutol resistant embB ARO:3000235 embB gene encodes for an arabinosyl transferase in the arabinogalactan synthesis pathway. It is inhibited by ethambutol. Mutations within the ERDR region of embB confers resistance to ethambutol. PMID:21300839 PMID:21444710 PMID:9142129 This inducible cluster confers high resistance to both vancomycin and teicoplanin by allowing restructuring of peptidoglycan precursors to end in D-Ala-D-Lac. The vanA gene cluster can be located either on plasmids or on the chromosome. Gene orientation: vanRSHAXYZ. vanA_cluster antibiotic_resistance ARO:3000236 glycopeptide resistance gene cluster VanA ARO:3000236 This inducible cluster confers high resistance to both vancomycin and teicoplanin by allowing restructuring of peptidoglycan precursors to end in D-Ala-D-Lac. The vanA gene cluster can be located either on plasmids or on the chromosome. Gene orientation: vanRSHAXYZ. PMID:16323116 PMID:8380148 PMID:8843432 vanA_cluster TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex. PDB:1EK9 TolC antibiotic_resistance ARO:3000237 TolC ARO:3000237 TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex. PMID:10879525 PMID:11589692 PMID:12163644 PMID:14630321 PMID:16359323 TolC This inducible cluster confers resistance to vancomycin but organisms remain sensitive to teicoplanin by allowing restructuring of peptidoglycan precursors to end in D-Ala-D-Lac. Sensitivity to teicoplanin is due to lack of binding to the sensor kinase VanS. The vanB gene cluster can be located either on plasmids or on the chromosome. Gene orientation: vanRSYWHBX. vanB_cluster antibiotic_resistance ARO:3000238 glycopeptide resistance gene cluster VanB ARO:3000238 This inducible cluster confers resistance to vancomycin but organisms remain sensitive to teicoplanin by allowing restructuring of peptidoglycan precursors to end in D-Ala-D-Lac. Sensitivity to teicoplanin is due to lack of binding to the sensor kinase VanS. The vanB gene cluster can be located either on plasmids or on the chromosome. Gene orientation: vanRSYWHBX. PMID:16323116 PMID:8654967 vanB_cluster Reduction in permeability to antibiotic, generally through reduced production of porins, can provide resistance. antibiotic_resistance ARO:3000244 reduced permeability to antibiotic ARO:3000244 Reduction in permeability to antibiotic, generally through reduced production of porins, can provide resistance. PMID:19100346 PMID:2848006 RNA-polymerase binding protein which confers resistance to rifampin. RbpA antibiotic_resistance ARO:3000245 RbpA ARO:3000245 RNA-polymerase binding protein which confers resistance to rifampin. PMID:16629670 PMID:21415119 RbpA Confers low vancomycin resistance by engineering peptidoglycan precursors ending in D-Ala-D-Ser in an inducible or constitutive manner. The vanC cluster is intrinsic to the Enterococcus gallinarum chromosome. vanC organisms remain susceptible to teicoplanin. Gene orientation: vanC(XY)TRS. vanC_cluster antibiotic_resistance ARO:3000246 glycopeptide resistance gene cluster VanC ARO:3000246 Confers low vancomycin resistance by engineering peptidoglycan precursors ending in D-Ala-D-Ser in an inducible or constitutive manner. The vanC cluster is intrinsic to the Enterococcus gallinarum chromosome. vanC organisms remain susceptible to teicoplanin. Gene orientation: vanC(XY)TRS. PMID:10817725 PMID:12615855 PMID:1551598 PMID:16323116 PMID:7986009 vanC_cluster A tetrameric protein that converts phosphoenolpyruvate (PEP) to phosponopyruvate (Ppyr). PDB:1S2T Fom1 antibiotic_resistance ARO:3000247 phosphoenolpyruvate (PEP) mutase ARO:3000247 A tetrameric protein that converts phosphoenolpyruvate (PEP) to phosponopyruvate (Ppyr). PMID:15078090 DnaA is a chromosomal replication initiation protein which binds and interacts with RNA polymerase in Escherichia coli. A surplus of DnaA present in a cell has been shown to confer resistance to the antibiotic Rifampicin. Normally, rifampicin inhibits initiation of transcription by RNA polymerase, but a surplus of DnaA available at the origin has been shown to disrupt Rifampicin activity and confer resistance. DnaA antibiotic_resistance ARO:3000248 DnaA ARO:3000248 DnaA is a chromosomal replication initiation protein which binds and interacts with RNA polymerase in Escherichia coli. A surplus of DnaA present in a cell has been shown to confer resistance to the antibiotic Rifampicin. Normally, rifampicin inhibits initiation of transcription by RNA polymerase, but a surplus of DnaA available at the origin has been shown to disrupt Rifampicin activity and confer resistance. PMID:19170875 DnaA ATP-dependent kinase modifies the C-3 hydroxyl group of chloramphenicol. Source is the chloramphenicol producer Streptomyces venezuelae. antibiotic_resistance ARO:3000249 chloramphenicol phosphotransferase ARO:3000249 ATP-dependent kinase modifies the C-3 hydroxyl group of chloramphenicol. Source is the chloramphenicol producer Streptomyces venezuelae. PMID:10835366 PMID:7592948 ErmC is a methyltransferase that catalyzes the methylation of A2058 of the 23S ribosomal RNA in two steps. Expression of ErmC is inducible by erythromycin. The leader peptide causes attenuation of the mRNA and stabilizes the structure preventing further translation. When erythromycin is present, it binds the leader peptide causing a change in conformation allowing for the expression of ErmC. ErmC ErmC' ermIM ermM antibiotic_resistance ARO:3000250 ErmC ARO:3000250 ErmC is a methyltransferase that catalyzes the methylation of A2058 of the 23S ribosomal RNA in two steps. Expression of ErmC is inducible by erythromycin. The leader peptide causes attenuation of the mRNA and stabilizes the structure preventing further translation. When erythromycin is present, it binds the leader peptide causing a change in conformation allowing for the expression of ErmC. PMID:18439898 PMID:2113911 PMID:2492520 PMID:6792593 ErmC MsrA is an ABC-F subfamily ribosomal protection protein expressed in Staphylococcus species which confers resistance to erythromycin and streptogramin B antibiotics through antibiotic target protection mechanisms. It is associated with plasmid DNA. msr(A) msrA antibiotic_resistance ARO:3000251 msrA ARO:3000251 MsrA is an ABC-F subfamily ribosomal protection protein expressed in Staphylococcus species which confers resistance to erythromycin and streptogramin B antibiotics through antibiotic target protection mechanisms. It is associated with plasmid DNA. PMID:15914491 msrA Homologous to vanA, contains a D-Ala-D-Lac ligase. This cluster is constitutively expressed in the chromosome due to a dysfunctional D-ala-D-ala ligase and confers moderate resistance to both vancomycin and teicoplanin. Gene orientation: vanRSYHDX. vanD_cluster antibiotic_resistance ARO:3000253 glycopeptide resistance gene cluster VanD ARO:3000253 Homologous to vanA, contains a D-Ala-D-Lac ligase. This cluster is constitutively expressed in the chromosome due to a dysfunctional D-ala-D-ala ligase and confers moderate resistance to both vancomycin and teicoplanin. Gene orientation: vanRSYHDX. PMID:11344152 PMID:12499162 PMID:16323116 PMID:9303405 vanD_cluster emrY is a multidrug transport that moves substrates across the inner membrane of the Gram-negative E. coli. It is a homolog of emrB. emrY antibiotic_resistance ARO:3000254 emrY ARO:3000254 emrY is a multidrug transport that moves substrates across the inner membrane of the Gram-negative E. coli. It is a homolog of emrB. PMID:12501312 emrY Homologous to vanA, contains a D-Ala-D-Lac ligase. The vanF gene cluster is inducible and confers high resistance to vancomycin in Paenibacillus popilliae. vanF organisms remain susceptible to teicoplanin. Gene orientation: RSYZHFX. vanF_cluster antibiotic_resistance ARO:3000255 glycopeptide resistance gene cluster VanF ARO:3000255 Homologous to vanA, contains a D-Ala-D-Lac ligase. The vanF gene cluster is inducible and confers high resistance to vancomycin in Paenibacillus popilliae. vanF organisms remain susceptible to teicoplanin. Gene orientation: RSYZHFX. PMID:10681342 PMID:15980329 vanF_cluster Homologous to vanA, contains a D-Ala-D-Lac ligase. The plasmid-located vanM gene cluster is inducible and confers high resistance to vancomycin and teicoplanin. Gene orientation: RSYHMX. vanM_cluster antibiotic_resistance ARO:3000256 glycopeptide resistance gene cluster VanM ARO:3000256 Homologous to vanA, contains a D-Ala-D-Lac ligase. The plasmid-located vanM gene cluster is inducible and confers high resistance to vancomycin and teicoplanin. Gene orientation: RSYHMX. PMID:20733041 vanM_cluster Contains a D-Ala-D-Ser ligase. The vanG gene cluster is inducible and confers low resistance to vancomycin. vanG organisms remain susceptible to teicoplanin. It is the only van gene cluster that contains two vanY genes. Gene orientation: vanRSYWGYT. vanG_cluster antibiotic_resistance ARO:3000257 glycopeptide resistance gene cluster VanG ARO:3000257 Contains a D-Ala-D-Ser ligase. The vanG gene cluster is inducible and confers low resistance to vancomycin. vanG organisms remain susceptible to teicoplanin. It is the only van gene cluster that contains two vanY genes. Gene orientation: vanRSYWGYT. PMID:11036060 PMID:16323116 PMID:19851013 vanG_cluster Homologous to VanC, contains a D-Ala-D-Ser ligase. The chromosome-located vanE gene cluster is inducible and confers low resistance to vancomycin. vanE organisms remain susceptible to teicoplanin. Gene orientation: E(XY)TRS. vanE_cluster antibiotic_resistance ARO:3000259 glycopeptide resistance gene cluster VanE ARO:3000259 Homologous to VanC, contains a D-Ala-D-Ser ligase. The chromosome-located vanE gene cluster is inducible and confers low resistance to vancomycin. vanE organisms remain susceptible to teicoplanin. Gene orientation: E(XY)TRS. PMID:10471558 PMID:12019119 PMID:12426332 PMID:16323116 vanE_cluster Homologous to VanC, contains a D-Ala-D-Ser ligase. The chromosome-located vanL gene cluster is inducible and confers low resistance to vancomycin. vanL organisms remain susceptible to teicoplanin. It is the only van gene cluster with two vanT genes. Gene orientation: vanL(XY)TmTrRS. vanL_cluster antibiotic_resistance ARO:3000260 glycopeptide resistance gene cluster VanL ARO:3000260 Homologous to VanC, contains a D-Ala-D-Ser ligase. The chromosome-located vanL gene cluster is inducible and confers low resistance to vancomycin. vanL organisms remain susceptible to teicoplanin. It is the only van gene cluster with two vanT genes. Gene orientation: vanL(XY)TmTrRS. PMID:18458129 vanL_cluster When bound to different sigma factors, RNA-polymerase may possess an altered sensitivity to rifampin-mediated inhibition. Sequence data unavailable. antibiotic_resistance ARO:3000261 sigma factor conferring resistance to rifampin ARO:3000261 When bound to different sigma factors, RNA-polymerase may possess an altered sensitivity to rifampin-mediated inhibition. Sequence data unavailable. PMID:9862449 The bla operon is composed of blaZ/blaR1/blaI. antibiotic_resistance ARO:3000262 bla operon ARO:3000262 In the presence of antibiotic stress, E. coli overexpresses the global activator protein MarA, which besides inducing MDR efflux pump AcrAB, also down- regulates synthesis of the porin OmpF. marA antibiotic_resistance ARO:3000263 marA ARO:3000263 In the presence of antibiotic stress, E. coli overexpresses the global activator protein MarA, which besides inducing MDR efflux pump AcrAB, also down- regulates synthesis of the porin OmpF. PMID:12027588 PMID:2848006 PMID:9333027 marA EmrE is a small multidrug transporter that functions as a homodimer and that couples the efflux of small polyaromatic cations from the cell with the import of protons down an electrochemical gradient. EmrE is found in E. coli and P. aeruginosa. antibiotic_resistance ARO:3000264 emrE ARO:3000264 EmrE is a small multidrug transporter that functions as a homodimer and that couples the efflux of small polyaromatic cations from the cell with the import of protons down an electrochemical gradient. EmrE is found in E. coli and P. aeruginosa. PMID:12499164 PMID:17360700 PMID:17942072 PMID:17976529 PMID:18006522 PMID:19167526 PMID:19171974 In the presence of antibiotic stress, E. coli overexpresses the global activator protein MarA, which besides inducing MDR efflux pump AcrAB, also down- regulates synthesis of the porin OmpF. antibiotic_resistance ARO:3000265 porin OmpF ARO:3000265 In the presence of antibiotic stress, E. coli overexpresses the global activator protein MarA, which besides inducing MDR efflux pump AcrAB, also down- regulates synthesis of the porin OmpF. PMID:19100346 PMID:2848006 The inactivation of antibiotics by the enzymatic addition of ADP-ribose from NAD+. antibiotic_resistance ARO:3000266 ADP-ribosylation of antibiotic conferring resistance ARO:3000266 The mec operon is composed of mecA/mecR1/mecI. antibiotic_resistance ARO:3000268 mec operon ARO:3000268 Brodimoprim is a structural derivative of trimethoprim and an inhibitor of bacterial dihydrofolate reductase. The 4-methoxy group of trimethoprim is replaced with a bromine atom. CAS:56518-41-3 ChEBI:131726 ChEMBL:CHEMBL31891 PubChem:68760 antibiotic_resistance ARO:3000269 brodimoprim ARO:3000269 Brodimoprim is a structural derivative of trimethoprim and an inhibitor of bacterial dihydrofolate reductase. The 4-methoxy group of trimethoprim is replaced with a bromine atom. PMID:10026296 PMID:7562018 PMID:8195838 Enzymes or other proteins either directly or indirectly reducing overall permeability to antibiotics. antibiotic_resistance ARO:3000270 protein modulating permeability to antibiotic ARO:3000270 Enzymes or other proteins either directly or indirectly reducing overall permeability to antibiotics. PMID:19100346 PMID:2848006 Point mutations in gyrA confer antibiotic resistance by preventing drugs from binding the alpha-subunit of gyrase, essential for DNA supercoiling. antibiotic_resistance ARO:3000273 antibiotic resistant DNA topoisomerase subunit gyrA ARO:3000273 Point mutations in parC confer antibiotic resistance by preventing drugs from binding the parC subunit of topoisomerase IV, essential for DNA decatanation and relaxation. antibiotic_resistance ARO:3000274 antibiotic resistant DNA topoisomerase subunit parC ARO:3000274 Sulfonamides are broad spectrum, synthetic antibiotics that contain the sulfonamide group. Sulfonamides inhibit dihydropteroate synthase, which catalyzes the conversion of p-aminobenzoic acid to dihydropteroic acid as part of the tetrahydrofolic acid biosynthetic pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor of many nucleotides and amino acids. Many sulfamides are taken with trimethoprim, an inhibitor of dihydrofolate reductase, also disturbing the trihydrofolic acid synthesis pathway. antibiotic_resistance ARO:3000282 sulfonamide antibiotic ARO:3000282 Sulfonamides are broad spectrum, synthetic antibiotics that contain the sulfonamide group. Sulfonamides inhibit dihydropteroate synthase, which catalyzes the conversion of p-aminobenzoic acid to dihydropteroic acid as part of the tetrahydrofolic acid biosynthetic pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor of many nucleotides and amino acids. Many sulfamides are taken with trimethoprim, an inhibitor of dihydrofolate reductase, also disturbing the trihydrofolic acid synthesis pathway. PMID:15673783 Tetroxoprim is a trimethoprim derivative that inhibits bacterial dihydrofolate reductase. CAS:53808-87-0 ChEBI:135420 ChEMBL:CHEMBL32039 PubChem:65450 antibiotic_resistance ARO:3000284 tetroxoprim ARO:3000284 Tetroxoprim is a trimethoprim derivative that inhibits bacterial dihydrofolate reductase. PMID:3043259 PMID:7036848 Stabilizes the C-P bond in phosphonopyruvate formed by phophoenolpyruvate mutase by catalyzing the self-removal of the carboxyl group. Fom2 antibiotic_resistance ARO:3000299 phosphonopyruvate decarboxylase ARO:3000299 Stabilizes the C-P bond in phosphonopyruvate formed by phophoenolpyruvate mutase by catalyzing the self-removal of the carboxyl group. PMID:10786631 LsaA is an ABC-F subfamily protein expressed in Enterococcus faecalis. It confers resistance to clindamycin, quinupristin-dalfopristin, and dalfopristin. lsaA antibiotic_resistance ARO:3000300 lsaA ARO:3000300 LsaA is an ABC-F subfamily protein expressed in Enterococcus faecalis. It confers resistance to clindamycin, quinupristin-dalfopristin, and dalfopristin. PMID:12019099 PMID:15914491 PMID:21245447 lsaA EmrD is a multidrug transporter from the Major Facilitator Superfamily (MFS) primarily found in Escherichia coli. EmrD couples efflux of amphipathic compounds with proton import across the plasma membrane. PDB:2GFP emrD antibiotic_resistance ARO:3000309 emrD ARO:3000309 EmrD is a multidrug transporter from the Major Facilitator Superfamily (MFS) primarily found in Escherichia coli. EmrD couples efflux of amphipathic compounds with proton import across the plasma membrane. PMID:16675700 PMID:16842212 PMID:8240355 PMID:8987357 emrD The mphA gene encodes for resistance enzyme MPH(2')-I which preferentially inactivate 14-membered macrolides (e.g.erythromycin, telithromycin, roxithromycin) over 16-membered macrolides (e.g.tylosin, spiramycin). It phosphorylates macrolides at 2'-OH hydroxyl of desosamine sugar of macrolides in a GTP-dependent manner. macrolide 2'-phosphotransferase I mphA antibiotic_resistance ARO:3000316 mphA ARO:3000316 The mphA gene encodes for resistance enzyme MPH(2')-I which preferentially inactivate 14-membered macrolides (e.g.erythromycin, telithromycin, roxithromycin) over 16-membered macrolides (e.g.tylosin, spiramycin). It phosphorylates macrolides at 2'-OH hydroxyl of desosamine sugar of macrolides in a GTP-dependent manner. PMID:17302923 PMID:20231391 PMID:29317655 PMID:8619599 mphA The mphB gene encodes for MPH(2')-II. This enzymes phosphorylates 14-membered and 16-membered macrolides. It phosphorylates macrolides in GTP- dependent manner at 2'-OH hydroxyl of desosamine sugar of macrolides. macrolide 2'-phosphotransferase II mphB antibiotic_resistance ARO:3000318 mphB ARO:3000318 The mphB gene encodes for MPH(2')-II. This enzymes phosphorylates 14-membered and 16-membered macrolides. It phosphorylates macrolides in GTP- dependent manner at 2'-OH hydroxyl of desosamine sugar of macrolides. PMID:1330822 PMID:17302923 PMID:29317655 PMID:8900063 PMID:9503630 mphB The mphC gene was identified from Staphylococcus aureus. This gene shows similarity to mphB gene from Escherchia coli. mphC antibiotic_resistance ARO:3000319 mphC ARO:3000319 The mphC gene was identified from Staphylococcus aureus. This gene shows similarity to mphB gene from Escherchia coli. PMID:12670694 PMID:17302923 PMID:29317655 mphC Hydrolytic enzymes that cleave the macrocycle lactone ring of macrolide antibiotics. antibiotic_resistance ARO:3000320 macrolide esterase ARO:3000320 Hydrolytic enzymes that cleave the macrocycle lactone ring of macrolide antibiotics. PMID:22303981 Hydrolysis of the the macrocycle lactone ring of macrolide antibiotics. antibiotic_resistance ARO:3000321 hydrolysis of macrolide macrocycle lactone ring ARO:3000321 A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 3-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 3-amino group of the compound. antibiotic_resistance ARO:3000322 AAC(3) ARO:3000322 A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 3-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 3-amino group of the compound. PMID:10639379 PMID:12709352 PMID:15388438 PMID:15728939 PMID:1577689 PMID:1649572 PMID:18467306 PMID:18476779 PMID:19709289 PMID:19949054 PMID:2060791 PMID:2549372 PMID:2914849 PMID:3892230 PMID:6318050 PMID:7486920 PMID:8257126 Sulfadiazine is a potent inhibitor of dihydropteroate synthase, interfering with the tetrahydrofolic biosynthesis pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor to many nucleotides and amino acids. CAS:68-35-9 ChEBI:9328 ChEMBL:CHEMBL439 PubChem:5215 antibiotic_resistance ARO:3000324 sulfadiazine ARO:3000324 Sulfadiazine is a potent inhibitor of dihydropteroate synthase, interfering with the tetrahydrofolic biosynthesis pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor to many nucleotides and amino acids. PMID:4597736 Sulfadimidine is an alkaline sulfonamide antibiotic that inhibits dihydropteroate synthase, and enzyme in the tetrahydrofolic acid biosynthesis pathway. This interferes with the production of folate, which is a precursor to many amino acids and nucleotides. CAS:57-68-1 ChEBI:102265 ChEMBL:CHEMBL446 PubChem:5327 sulfamethazine antibiotic_resistance ARO:3000325 sulfadimidine ARO:3000325 Sulfadimidine is an alkaline sulfonamide antibiotic that inhibits dihydropteroate synthase, and enzyme in the tetrahydrofolic acid biosynthesis pathway. This interferes with the production of folate, which is a precursor to many amino acids and nucleotides. PMID:15673783 ErmE is a methyltransferase found in the erythromycin producer Saccharopolyspora erythraea. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. The gene is found within the erythromycin biosynthetic cluster and is responsible for self-resistance. ErmE ermE2 antibiotic_resistance ARO:3000326 ErmE ARO:3000326 ErmE is a methyltransferase found in the erythromycin producer Saccharopolyspora erythraea. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. The gene is found within the erythromycin biosynthetic cluster and is responsible for self-resistance. PMID:12019067 PMID:3117622 PMID:7961464 PMID:9735285 PMID:9973557 ErmE Sulfadoxine is an inhibitor of dihydropteroate synthase, interfering with the tetrahydrofolic biosynthesis pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor to many nucleotides and amino acids. CAS:2447-57-6 ChEBI:9329 ChEMBL:CHEMBL1539 PubChem:17134 antibiotic_resistance ARO:3000327 sulfadoxine ARO:3000327 Sulfadoxine is an inhibitor of dihydropteroate synthase, interfering with the tetrahydrofolic biosynthesis pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor to many nucleotides and amino acids. PMID:21029476 Single nucleotide polymorphisms (SNPs) in rRNA can confer antibiotic resistance to drugs that target the bacterial ribosome. antibiotic_resistance ARO:3000328 rRNA with mutation conferring antibiotic resistance ARO:3000328 Sulfamethoxazole is a sulfonamide antibiotic usually taken with trimethoprim, a diaminopyrimidine antibiotic. Sulfamethoxazole inhibits dihydropteroate synthase, essential to tetrahydrofolic acid biosynthesis. This pathway generates compounds used in the synthesis of many amino acids and nucleotides. CAS:723-46-6 ChEBI:9332 ChEMBL:CHEMBL443 PubChem:5329 antibiotic_resistance ARO:3000329 sulfamethoxazole ARO:3000329 Sulfamethoxazole is a sulfonamide antibiotic usually taken with trimethoprim, a diaminopyrimidine antibiotic. Sulfamethoxazole inhibits dihydropteroate synthase, essential to tetrahydrofolic acid biosynthesis. This pathway generates compounds used in the synthesis of many amino acids and nucleotides. PMID:1093654 Sulfisoxazole is an inhibitor of dihydropteroate synthase, interfering with the tetrahydrofolic biosynthesis pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor to many nucleotides and amino acids. CAS:127-69-5 ChEBI:102484 ChEMBL:CHEMBL453 PubChem:5344 antibiotic_resistance ARO:3000330 sulfisoxazole ARO:3000330 Sulfisoxazole is an inhibitor of dihydropteroate synthase, interfering with the tetrahydrofolic biosynthesis pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor to many nucleotides and amino acids. PMID:978409 Macrolide phosphotransferases (MPH) are enzymes encoded by macrolide phosphotransferase genes (mph genes). These enzymes phosphorylate macrolides in GTP dependent manner at 2'-OH of desosamine sugar thereby inactivating them. Characterized MPH's are differentiated based on their substrate specificity. antibiotic_resistance ARO:3000333 macrolide phosphotransferase (MPH) ARO:3000333 Point mutations in bacterial 23S rRNA from the large ribosomal subunit that confer resistance to antibiotics. Antibiotics such as linezolid block peptide synthesis through peptidyl transferase activity. Mutations in the 23S rRNA subunit reduce antibiotic binding affinity at specific sites, conferring resistance. antibiotic_resistance ARO:3000336 23S rRNA with mutation conferring antibiotic resistance ARO:3000336 Point mutations in bacterial 23S rRNA from the large ribosomal subunit that confer resistance to antibiotics. Antibiotics such as linezolid block peptide synthesis through peptidyl transferase activity. Mutations in the 23S rRNA subunit reduce antibiotic binding affinity at specific sites, conferring resistance. PMID:15700955 PMID:18174304 Iclaprim is a bactericidal compound that inhibits dihydrofolate reductase. It is used against clinically important Gram-positive pathogens, including methicillin-sensitive Staphylococcus aureus and methicillin-resistant S. aureus. CAS:192314-93-5 ChEBI:31724 ChEMBL:CHEMBL134561 PubChem:213043 AR-100 RO-48-2622 antibiotic_resistance ARO:3000337 iclaprim ARO:3000337 Iclaprim is a bactericidal compound that inhibits dihydrofolate reductase. It is used against clinically important Gram-positive pathogens, including methicillin-sensitive Staphylococcus aureus and methicillin-resistant S. aureus. PMID:19289528 PMID:19622858 Genes that confer antibiotic resistance by hydrolyzing bonds to linearize and deactivate antibiotics. antibiotic_resistance ARO:3000338 linearization of antibiotic conferring resistance ARO:3000338 A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 2'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 2-amino group of the compound. antibiotic_resistance ARO:3000341 AAC(2') ARO:3000341 A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 2'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 2-amino group of the compound. PMID:18931120 PMID:8407825 PMID:9159528 Enzymes that inactivate fosfomycin by chemical modification. antibiotic_resistance ARO:3000342 fosfomycin inactivation enzyme ARO:3000342 Efflux pump proteins contained within Mycobacterial genomes which confer resistance to a number of different antibiotics including aminoglycosides, and tetracyclines. tap antibiotic_resistance ARO:3000343 tap ARO:3000343 Efflux pump proteins contained within Mycobacterial genomes which confer resistance to a number of different antibiotics including aminoglycosides, and tetracyclines. PMID:15057575 PMID:9811639 tap EmrAB-TolC is a multidrug efflux system found in E. coli. EmrB is the electrochemical-gradient powered transporter; EmrA is the linker; and TolC is the outer membrane channel. It confers resistance to nalidixic acid and thiolactomycin. EmrAB-TolC antibiotic_resistance ARO:3000344 EmrAB-TolC ARO:3000344 EmrAB-TolC is a multidrug efflux system found in E. coli. EmrB is the electrochemical-gradient powered transporter; EmrA is the linker; and TolC is the outer membrane channel. It confers resistance to nalidixic acid and thiolactomycin. PMID:7730261 EmrAB-TolC A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. antibiotic_resistance ARO:3000345 AAC(6') ARO:3000345 A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 6'-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 6-amino group of the compound. PMID:15673721 ErmA confers the MLSb phenotype. Similar to ErmC, Expression of ErmA is inducible by erythromycin. The leader peptide causes attenuation of the mRNA and stabilizes the structure preventing further translation. When erythromycin is present, it binds the leader peptide causing a change in conformation allowing for the expression of ErmA. ErmA ermTR antibiotic_resistance ARO:3000347 ErmA ARO:3000347 ErmA confers the MLSb phenotype. Similar to ErmC, Expression of ErmA is inducible by erythromycin. The leader peptide causes attenuation of the mRNA and stabilizes the structure preventing further translation. When erythromycin is present, it binds the leader peptide causing a change in conformation allowing for the expression of ErmA. PMID:18952616 ErmA In the presence of ATP and magnesium (II), fosfomycin gets phosphorylated at the phosphate group resulting in a diphosphate group which inactivates the antibiotic. antibiotic_resistance ARO:3000359 fosfomycin phosphotransferase ARO:3000359 In the presence of ATP and magnesium (II), fosfomycin gets phosphorylated at the phosphate group resulting in a diphosphate group which inactivates the antibiotic. PMID:10681332 PMID:18701452 EreA is an erythromycin esterase that hydrolyses the drug's lactone ring. Ere(A) EreA antibiotic_resistance ARO:3000361 EreA ARO:3000361 EreA is an erythromycin esterase that hydrolyses the drug's lactone ring. PMID:22303981 EreA EreB is an erythromycin esterase-like protein that hydrolyses the drug's lactone ring. Ere(B) EreB antibiotic_resistance ARO:3000363 EreB ARO:3000363 EreB is an erythromycin esterase-like protein that hydrolyses the drug's lactone ring. PMID:10908116 EreB VanC is a D-Ala-D-Ala ligase homolog that synthesizes D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is specific to Enterococcus gallinarum and E. casseliflavus, providing intrinsic resistance. vanC antibiotic_resistance ARO:3000368 vanC ARO:3000368 VanC is a D-Ala-D-Ala ligase homolog that synthesizes D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is specific to Enterococcus gallinarum and E. casseliflavus, providing intrinsic resistance. PMID:1551598 PMID:16323116 PMID:9666008 vanC The mtr (multiple transferable resistance) system of Neisseria gonorrhoeae confers resistance to many hydrophobic agents including antibiotics, fatty-acids and detergents. MtrCDE is homologous to AcrAB-TolC, where MtrC is the membrane fusion protein, MtrD is the inner membrane transporter, and MtrE is the outer membrane channel protein. MtrCDE antibiotic_resistance ARO:3000369 MtrCDE ARO:3000369 The mtr (multiple transferable resistance) system of Neisseria gonorrhoeae confers resistance to many hydrophobic agents including antibiotics, fatty-acids and detergents. MtrCDE is homologous to AcrAB-TolC, where MtrC is the membrane fusion protein, MtrD is the inner membrane transporter, and MtrE is the outer membrane channel protein. PMID:14500476 PMID:7711899 MtrCDE Many drugs target topoisomerases to inhibit DNA synthesis. Resistant DNA topoisomerase subunits prevent antibiotic binding and thus confer resistance. antibiotic_resistance ARO:3000370 antibiotic resistant DNA topoisomerase subunit ARO:3000370 VanT is a membrane bound serine racemase, converting L-serine to D-serine. It is associated with VanC, which incorporated D-serine into D-Ala-D-Ser terminal end of peptidoglycan subunits that have a decreased binding affinity with vancomycin. It was isolated from Enterococcus gallinarum. antibiotic_resistance ARO:3000372 vanT ARO:3000372 VanT is a membrane bound serine racemase, converting L-serine to D-serine. It is associated with VanC, which incorporated D-serine into D-Ala-D-Ser terminal end of peptidoglycan subunits that have a decreased binding affinity with vancomycin. It was isolated from Enterococcus gallinarum. PMID:10817725 PMID:10878136 EmrKY is a homolog of EmrAB found in E. coli. Together with TolC, it is a tripartite multidrug transporter. EmrKY-TolC antibiotic_resistance ARO:3000373 EmrKY-TolC ARO:3000373 EmrKY is a homolog of EmrAB found in E. coli. Together with TolC, it is a tripartite multidrug transporter. PMID:12501312 PMID:21954395 EmrKY-TolC ErmB confers the MLSb phenotype. Similar to ErmC, expression of ErmB is inducible by erythromycin. The leader peptide causes attenuation of the mRNA and stabilizes the structure preventing further translation. When erythromycin is present, it binds the leader peptide causing a change in conformation allowing for the expression of ErmB. PDB:1YUB ErmB erm erm2 ermAM ermAMR ermBC ermBP ermBZ1 ermBZ2 ermIP ermP antibiotic_resistance ARO:3000375 ErmB ARO:3000375 ErmB confers the MLSb phenotype. Similar to ErmC, expression of ErmB is inducible by erythromycin. The leader peptide causes attenuation of the mRNA and stabilizes the structure preventing further translation. When erythromycin is present, it binds the leader peptide causing a change in conformation allowing for the expression of ErmB. PMID:10508434 PMID:18299414 PMID:9187657 ErmB vgb (Virginiamycin B) lyase inactivates type B streptogramin antibiotics by linearizing the streptogramin lactone ring at the ester linkage through an elimination mechanism, thus conferring resistance to these compounds. antibiotic_resistance ARO:3000376 streptogramin vgb lyase ARO:3000376 vgb (Virginiamycin B) lyase inactivates type B streptogramin antibiotics by linearizing the streptogramin lactone ring at the ester linkage through an elimination mechanism, thus conferring resistance to these compounds. PMID:11467949 MexA is the membrane fusion protein of the MexAB-OprM multidrug efflux complex. PDB:1T5E MexA antibiotic_resistance ARO:3000377 MexA ARO:3000377 MexA is the membrane fusion protein of the MexAB-OprM multidrug efflux complex. PMID:15117957 MexA MexB is the inner membrane multidrug exporter of the efflux complex MexAB-OprM. PDB:2V50 MexB antibiotic_resistance ARO:3000378 MexB ARO:3000378 MexB is the inner membrane multidrug exporter of the efflux complex MexAB-OprM. PMID:14973037 PMID:19361527 PMID:20583998 PMID:21178960 MexB OprM is an outer membrane factor protein found in Pseudomonas aeruginosa and Burkholderia vietnamiensis. It is part of the MexAB-OprM, MexVW-OprM, MexXY-OprM and the AmrAB-OprM complex. PDB:1WP1 OprM antibiotic_resistance ARO:3000379 OprM ARO:3000379 OprM is an outer membrane factor protein found in Pseudomonas aeruginosa and Burkholderia vietnamiensis. It is part of the MexAB-OprM, MexVW-OprM, MexXY-OprM and the AmrAB-OprM complex. PMID:15797729 PMID:16508113 PMID:16511029 OprM FosC is an enzyme that phosphorylates fosfomycin to confer resistance. FosC antibiotic_resistance ARO:3000380 FosC ARO:3000380 FosC is an enzyme that phosphorylates fosfomycin to confer resistance. PMID:7492106 FosC Alternate proteins that have the same functions as other antibiotic target proteins, but are structurally different and thus resistant to antibiotics. These can replace the activity of other antibiotic-sensitive proteins in the presence of antibiotics. antibiotic_resistance ARO:3000381 antibiotic target replacement protein ARO:3000381 Azidamfenicol is a water soluble derivative of chloramphenicol, sharing the same mode of action of inhibiting peptide synthesis by interacting with the 23S RNA of the 50S ribosomal subunit. CAS:13838-08-9 ChEBI:135238 ChEMBL:CHEMBL278788 ChEMBL:CHEMBL3989525 PubChem:62858 antibiotic_resistance ARO:3000382 azidamfenicol ARO:3000382 Azidamfenicol is a water soluble derivative of chloramphenicol, sharing the same mode of action of inhibiting peptide synthesis by interacting with the 23S RNA of the 50S ribosomal subunit. PMID:15539072 AcrAB-TolC is a tripartite RND efflux system that confers resistance to tetracycline, chloramphenicol, ampicillin, nalidixic acid, and rifampin in Gram-negative bacteria. The system spans the cell membrane (AcrB) and the outer-membrane (TolC), and is linked together in the periplasm by AcrA. AcrAB-TolC antibiotic_resistance ARO:3000384 AcrAB-TolC ARO:3000384 AcrAB-TolC is a tripartite RND efflux system that confers resistance to tetracycline, chloramphenicol, ampicillin, nalidixic acid, and rifampin in Gram-negative bacteria. The system spans the cell membrane (AcrB) and the outer-membrane (TolC), and is linked together in the periplasm by AcrA. PMID:21513882 PMID:8550435 AcrAB-TolC Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation. CAS:56-75-7 ChEBI:17698 ChEMBL:CHEMBL130 PubChem:5959 CHL antibiotic_resistance ARO:3000385 chloramphenicol ARO:3000385 Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation. PMID:17737966 MexAB-OprM is a multidrug efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexA is the membrane fusion protein; MexB is the inner membrane transporter; and OprM is the outer membrane channel. MexAB-OprM is associated with resistance to fluoroquinolones, chloramphenicol, erythromycin, azithromycin, novobiocin, and certain β-lactams and lastly over-expression is linked to colistin resistance. MexAB-OprM antibiotic_resistance ARO:3000386 MexAB-OprM ARO:3000386 MexAB-OprM is a multidrug efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexA is the membrane fusion protein; MexB is the inner membrane transporter; and OprM is the outer membrane channel. MexAB-OprM is associated with resistance to fluoroquinolones, chloramphenicol, erythromycin, azithromycin, novobiocin, and certain β-lactams and lastly over-expression is linked to colistin resistance. PMID:16189126 PMID:17586626 PMID:18312276 PMID:18676884 PMID:9449262 MexAB-OprM Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome. phenicol antibiotic_resistance ARO:3000387 phenicol antibiotic ARO:3000387 Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome. PMID:12860128 Biosynthesis of streptoramin antibiotics. antibiotic_resistance ARO:3000388 streptogramin biosynthesis ARO:3000388 Type B streptogramins are cyclic hexa- or hepta-depsipeptides produced by NRPSs in Streptomyces. The NRPS contains 6 or 7 modules arranged on one or more genes. SnbA catalyzes the activation of the first residue, 3-hydroxypicolynic acid. SnbC then activates and incorporates threonine and aminobutyric acid. Lastly, SnbDE activates and incoporates the last four amino acids. The thioesterase domain is responsible for peptide cyclization, and it is located at the end of the assembly line. antibiotic_resistance ARO:3000389 streptogramin B biosynthesis ARO:3000389 Type B streptogramins are cyclic hexa- or hepta-depsipeptides produced by NRPSs in Streptomyces. The NRPS contains 6 or 7 modules arranged on one or more genes. SnbA catalyzes the activation of the first residue, 3-hydroxypicolynic acid. SnbC then activates and incorporates threonine and aminobutyric acid. Lastly, SnbDE activates and incoporates the last four amino acids. The thioesterase domain is responsible for peptide cyclization, and it is located at the end of the assembly line. PMID:900602 PMID:9006023 PMID:9303382 Enzyme responsible for the ADP-ribosylative inactivation of rifampin at the 23-OH position using NAD+. antibiotic_resistance ARO:3000390 rifampin ADP-ribosyltransferase (Arr) ARO:3000390 Enzyme responsible for the ADP-ribosylative inactivation of rifampin at the 23-OH position using NAD+. PMID:18349144 PMID:9869590 NorA is a multidrug efflux pump in Staphylococcus aureus that confers resistance to fluoroquinolones and other structurally unrelated antibiotics like acriflavine. It shares 30% similarity with NorA, and is a structural homolog of Bmr of Bacillus subtilis. It is regulated by arlRS and mgrA, the latter also known as NorR. norA antibiotic_resistance ARO:3000391 norA ARO:3000391 NorA is a multidrug efflux pump in Staphylococcus aureus that confers resistance to fluoroquinolones and other structurally unrelated antibiotics like acriflavine. It shares 30% similarity with NorA, and is a structural homolog of Bmr of Bacillus subtilis. It is regulated by arlRS and mgrA, the latter also known as NorR. PMID:12730173 PMID:15774883 PMID:8431010 norA Erm(37) is found in Mycobacterium species and confers the MLSb phenotype. In addition to methylation of A2058 this Erm methylates adjacent adenosines (A2057 and A2059) as well. Erm(37) Erm37 antibiotic_resistance ARO:3000392 Erm(37) ARO:3000392 Erm(37) is found in Mycobacterium species and confers the MLSb phenotype. In addition to methylation of A2058 this Erm methylates adjacent adenosines (A2057 and A2059) as well. PMID:14693532 PMID:16174779 Erm(37) Synthesis of glycopeptide antibiotics. antibiotic_resistance ARO:3000393 glycopeptide biosynthesis ARO:3000393 Biosynthesis of teicoplanin by Actinoplanes teichomyceticus. antibiotic_resistance ARO:3000394 Actinoplanes teichomyceticus teicoplanin gene cluster ARO:3000394 Biosynthesis of teicoplanin by Actinoplanes teichomyceticus. PMID:15113000 Sul1 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria. It is linked to other resistance genes of class 1 integrons. sul1 antibiotic_resistance ARO:3000410 sul1 ARO:3000410 Sul1 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria. It is linked to other resistance genes of class 1 integrons. PMID:11432417 PMID:17158944 PMID:17827139 PMID:18753343 PMID:19075060 PMID:21537009 sul1 Sul2 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria, usually found on small plasmids. sul2 antibiotic_resistance ARO:3000412 sul2 ARO:3000412 Sul2 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria, usually found on small plasmids. PMID:11432417 PMID:15722395 sul2 Sul3 is a sulfonamide resistant dihydropteroate synthase similar to Sul1 and Sul2. Its resistance gene was found encoded in E. coli plasmid DNA of sulfonamide resistant isolates. sul3 antibiotic_resistance ARO:3000413 sul3 ARO:3000413 Sul3 is a sulfonamide resistant dihydropteroate synthase similar to Sul1 and Sul2. Its resistance gene was found encoded in E. coli plasmid DNA of sulfonamide resistant isolates. PMID:12604565 sul3 Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. Qnr antibiotic_resistance ARO:3000419 quinolone resistance protein (qnr) ARO:3000419 Qnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics. PMID:15933203 PMID:19258263 PMID:19822894 NorB is a multidrug efflux pump in Staphylococcus aureus that confers resistance to fluoroquinolones and other structurally unrelated antibiotics like tetracycline. It shares 30% similarity with NorB, and is a structural homolog of Blt of Bacillus subtilis. It is regulated by mgrA, also known as NorR. norB antibiotic_resistance ARO:3000421 norB ARO:3000421 NorB is a multidrug efflux pump in Staphylococcus aureus that confers resistance to fluoroquinolones and other structurally unrelated antibiotics like tetracycline. It shares 30% similarity with NorB, and is a structural homolog of Blt of Bacillus subtilis. It is regulated by mgrA, also known as NorR. PMID:15774883 norB In the presence of ATP and magnesium (II), fosfomycin gets phosphorylated at the phosphate group resulting in a diphosphate group which inactivates the antibiotic. PDB:3D40 FomA antibiotic_resistance ARO:3000423 FomA ARO:3000423 In the presence of ATP and magnesium (II), fosfomycin gets phosphorylated at the phosphate group resulting in a diphosphate group which inactivates the antibiotic. PMID:10681332 PMID:18701452 FomA The enzymatic inactivation of rifampin by glycosylation at the 23-OH position. antibiotic_resistance ARO:3000443 rifampin glycosyltransferase ARO:3000443 The enzymatic inactivation of rifampin by glycosylation at the 23-OH position. PMID:22802246 PMID:8328779 The enzymatic inactivation of rifampin by phosphorylation at the 21-OH position. rphA antibiotic_resistance ARO:3000444 rphA ARO:3000444 The enzymatic inactivation of rifampin by phosphorylation at the 21-OH position. PMID:24778229 PMID:27103605 PMID:7928806 rphA Enzyme responsible for the decolorization of rifampin by monoxygenation. antibiotic_resistance ARO:3000445 rifampin monooxygenase ARO:3000445 Enzyme responsible for the decolorization of rifampin by monoxygenation. PMID:19942945 PMID:8980786 Mupirocin inhibits protein synthesis by interfering with isoleucyl-tRNA synthetase (ileS). Mutations in ileS can confer low-level mupirocin resistance. antibiotic_resistance ARO:3000446 antibiotic-resistant isoleucyl-tRNA synthetase (ileS) ARO:3000446 Mupirocin inhibits protein synthesis by interfering with isoleucyl-tRNA synthetase (ileS). Mutations in ileS can confer low-level mupirocin resistance. PMID:11599741 PMID:11796355 PMID:21421794 PMID:22252810 PMID:8067768 QepA1 is a plasmid-mediated efflux pump in E. coli, shown to contribute to fluoroquinolone resistance. It is regulated by sox genes, also known as global stress regulators. QepA QepA1 antibiotic_resistance ARO:3000448 QepA1 ARO:3000448 QepA1 is a plasmid-mediated efflux pump in E. coli, shown to contribute to fluoroquinolone resistance. It is regulated by sox genes, also known as global stress regulators. PMID:17548499 QepA1 An enzyme which on its own cannot provide fosfomycin resistance, however in conjunction with FomA, it leads to the formation of fosfomycin with three phosphates total, which makes it inactive. FomB antibiotic_resistance ARO:3000449 FomB ARO:3000449 An enzyme which on its own cannot provide fosfomycin resistance, however in conjunction with FomA, it leads to the formation of fosfomycin with three phosphates total, which makes it inactive. PMID:18701452 FomB Inactivation of an antibiotic via introduction a hydroxyl group (-OH). antibiotic_resistance ARO:3000450 hydroxylation of antibiotic conferring resistance ARO:3000450 Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux. antibiotic_resistance ARO:3000451 protein(s) and two-component regulatory system modulating antibiotic efflux ARO:3000451 Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux. PMID:14572535 PMID:24878531 Fluoroquinolones inhibit type II and type IV topoisomerases (2 strand breaking enzymes) such as GyrA/GyrB and ParC/ParE. Point mutations in the associated gyrA and parC genes, in particular in the 'quinolone resistance determining region' (QRDR), give rise to resistance to the class. antibiotic_resistance ARO:3000452 fluoroquinolone resistant DNA topoisomerase ARO:3000452 Fluoroquinolones inhibit type II and type IV topoisomerases (2 strand breaking enzymes) such as GyrA/GyrB and ParC/ParE. Point mutations in the associated gyrA and parC genes, in particular in the 'quinolone resistance determining region' (QRDR), give rise to resistance to the class. PMID:11504468 PMID:20802486 PMID:22279180 vat (Virginiamycin acetyltransferases) enzymes catalyze the transfer of an acetyl group from acetyl-CoA to the secondary alcohol of streptogramin A compounds, thus inactivating virginiamycin-like antibiotics and conferring resistance to these compounds. Streptogramin A acetyltransferase (SAT) antibiotic_resistance ARO:3000453 streptogramin vat acetyltransferase ARO:3000453 vat (Virginiamycin acetyltransferases) enzymes catalyze the transfer of an acetyl group from acetyl-CoA to the secondary alcohol of streptogramin A compounds, thus inactivating virginiamycin-like antibiotics and conferring resistance to these compounds. PMID:11841212 PMID:12771141 PMID:20713681 Polymyxin B is mixture of mostly polymyxins B1 and B2, mainly used for resistant gram-negative infections. They are polypeptides with cationic detergent action on cell membranes. CAS:1404-26-8 ChEBI:59063 ChEBI:8309 ChEMBL:CHEMBL3989738 ChEMBL:CHEMBL5314354 PubChem:49800004 antibiotic_resistance ARO:3000454 polymyxin B ARO:3000454 Polymyxin B is mixture of mostly polymyxins B1 and B2, mainly used for resistant gram-negative infections. They are polypeptides with cationic detergent action on cell membranes. PMID:17201926 Type A streptogramins are produced by a hybrid NRPS/PKS composed of 8 NRPS modules and 2 PKS modules. antibiotic_resistance ARO:3000455 streptogramin A biosynthesis ARO:3000455 Derivative of Chloramphenicol. The nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3). CAS:15318-45-3 ChEBI:32215 ChEMBL:CHEMBL1236282 PubChem:27200 antibiotic_resistance ARO:3000456 thiamphenicol ARO:3000456 Derivative of Chloramphenicol. The nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3). PMID:15539072 ParE is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Point mutations in ParE prevent anticoumarin antibiotics from inhibiting DNA synthesis, thus conferring resistance. antibiotic_resistance ARO:3000457 aminocoumarin resistant parE ARO:3000457 ParE is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Point mutations in ParE prevent anticoumarin antibiotics from inhibiting DNA synthesis, thus conferring resistance. PMID:16127057 Macrolide glycosyltransferases are enzymes encoded by macrolide glycosyltransferase genes and inactivate macrolides by glycosylating them at 2'-OH of desosamine sugar moiety. They are predominantly found in macrolide producers and are also found in non-producers and are used as a resistance mechanism. Different variants of this enzyme has been reported. antibiotic_resistance ARO:3000458 macrolide glycosyltransferase ARO:3000458 Macrolide glycosyltransferases are enzymes encoded by macrolide glycosyltransferase genes and inactivate macrolides by glycosylating them at 2'-OH of desosamine sugar moiety. They are predominantly found in macrolide producers and are also found in non-producers and are used as a resistance mechanism. Different variants of this enzyme has been reported. PMID:17376874 Biosynthesis of fosfomycin. antibiotic_resistance ARO:3000459 fosfomycin biosynthesis ARO:3000459 Florfenicol is a fluorine derivative of chloramphenicol, where the nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3) and the hydroxyl group (-OH), by a fluorine group (-F). The action mechanism is the same as chloramphenicol's, where the antibiotic binds to the 23S RNA of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. CAS:73231-34-2 ChEBI:87185 ChEMBL:CHEMBL1241590 PubChem:114811 antibiotic_resistance ARO:3000461 florfenicol ARO:3000461 Florfenicol is a fluorine derivative of chloramphenicol, where the nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3) and the hydroxyl group (-OH), by a fluorine group (-F). The action mechanism is the same as chloramphenicol's, where the antibiotic binds to the 23S RNA of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. PMID:15539072 A macrolide glycosyltransferase encoded by the mgtA gene in Streptomyces lividans. This enzyme inactivates macrolides using UDP-glucose as a cofactor. Its optimal substrates are lankamycin, calcomycin, rosaramicin, methymycin, and pikromycin, while interactions with erythomycin, oldeandomycin, azithromycin, and tylosin were weaker. It is inactive against spiramycin and carbomycin. Mechanism first described by Cundliffe, 1992. mgt mgtA antibiotic_resistance ARO:3000462 mgtA ARO:3000462 A macrolide glycosyltransferase encoded by the mgtA gene in Streptomyces lividans. This enzyme inactivates macrolides using UDP-glucose as a cofactor. Its optimal substrates are lankamycin, calcomycin, rosaramicin, methymycin, and pikromycin, while interactions with erythomycin, oldeandomycin, azithromycin, and tylosin were weaker. It is inactive against spiramycin and carbomycin. Mechanism first described by Cundliffe, 1992. PMID:1605601 PMID:1612452 mgtA A macrolide glycosyltransferase encoded by the gimA gene in Streptomyces ambofaciens, a natural producer of the macrolide antibiotic spiramycin. Chalcomycin, methymycin, tylosin, pikromycin, rosaramicin, oleandomycin, josamycin, and carbomycin are preferred substrates of gimA glycosyltransferase, while erythromycin and spiramycin have notably low binding affinities. GimA may be able to inactivate spiramycin precursors. Described by Gourmelen et al. 1998. gimA antibiotic_resistance ARO:3000463 gimA ARO:3000463 A macrolide glycosyltransferase encoded by the gimA gene in Streptomyces ambofaciens, a natural producer of the macrolide antibiotic spiramycin. Chalcomycin, methymycin, tylosin, pikromycin, rosaramicin, oleandomycin, josamycin, and carbomycin are preferred substrates of gimA glycosyltransferase, while erythromycin and spiramycin have notably low binding affinities. GimA may be able to inactivate spiramycin precursors. Described by Gourmelen et al. 1998. PMID:9756764 gimA Mutant forms of the porin Por result in reduced permeability to antibiotics, particularly tetracyclines and beta-lactams. Ngon_porin antibiotic_resistance ARO:3000464 Neisseria gonorrhoeae porin PIB (por) ARO:3000464 Mutant forms of the porin Por result in reduced permeability to antibiotics, particularly tetracyclines and beta-lactams. PMID:12183233 PMID:16547016 PMID:9797206 Ngon_porin OleI and OleD are glycosyltransferases found in Streptomyces antibioticus which is a natural producer of antibiotic oleandomycin. OleI glycosylates antibiotic oleandomycin whereas OleD can glycosylate a wide variety of macrolides. antibiotic_resistance ARO:3000465 ole glycosyltransferase ARO:3000465 OleI and OleD are glycosyltransferases found in Streptomyces antibioticus which is a natural producer of antibiotic oleandomycin. OleI glycosylates antibiotic oleandomycin whereas OleD can glycosylate a wide variety of macrolides. PMID:15984838 PMID:17376874 PMID:9680207 Dalbavancin is a semisynthetic second-generation lipoglycopeptide derived from teicoplanin. It binds to the D-Ala-D-Ala terminus of peptidoglycan precursors. It is used to treat Gram-positive bacteria and can be used to treat methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci. CAS:171500-79-1 ChEBI:82721 ChEMBL:CHEMBL3301669 PubChem:23724878 Zeven antibiotic_resistance ARO:3000466 dalbavancin ARO:3000466 Dalbavancin is a semisynthetic second-generation lipoglycopeptide derived from teicoplanin. It binds to the D-Ala-D-Ala terminus of peptidoglycan precursors. It is used to treat Gram-positive bacteria and can be used to treat methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci. PMID:15566329 PMID:17461743 PMID:27904526 New Delhi beta-lactamase NDM-5. NDM-5 antibiotic_resistance ARO:3000467 NDM-5 ARO:3000467 New Delhi beta-lactamase NDM-5. PMID:21930874 NDM-5 The enzyme responsible for the final step of fosfomycin biosynthesis. It converts S-2-hydroxypropylphosphonic acid (S-HPP) into fosfomycin via an oxidative cyclalization reaction. It uses Iron (II) or Zinc (II) as cofactors. PDB:1ZZ6 Fom4 HppE antibiotic_resistance ARO:3000469 hydroxypropylphosphonic acid epoxidase ARO:3000469 The enzyme responsible for the final step of fosfomycin biosynthesis. It converts S-2-hydroxypropylphosphonic acid (S-HPP) into fosfomycin via an oxidative cyclalization reaction. It uses Iron (II) or Zinc (II) as cofactors. PMID:16015285 PMID:16186494 Tet31 is a tetracycline efflux pump found in Aeromonas salmonicida, a Gram-negative bacteria. It has also been shown to be expressed in Gallibacterium anatis. tet(31) tet31 antibiotic_resistance ARO:3000476 tet(31) ARO:3000476 Tet31 is a tetracycline efflux pump found in Aeromonas salmonicida, a Gram-negative bacteria. It has also been shown to be expressed in Gallibacterium anatis. PMID:11381101 PMID:12383729 PMID:21145184 tet(31) Tet33 is a tetracycline efflux pump found in Gram-positive bacteria, including Arthrobacter and Corynebacterium. tet(33) tet33 tetA(33) antibiotic_resistance ARO:3000478 tet(33) ARO:3000478 Tet33 is a tetracycline efflux pump found in Gram-positive bacteria, including Arthrobacter and Corynebacterium. PMID:12383729 tet(33) Point mutations in DNA gyrase subunit B (gyrB) can result in resistance to aminocoumarins. These mutations usually involve arginine residues in organisms. antibiotic_resistance ARO:3000479 aminocoumarin resistant gyrB ARO:3000479 Point mutations in DNA gyrase subunit B (gyrB) can result in resistance to aminocoumarins. These mutations usually involve arginine residues in organisms. PMID:12604514 PMID:14993313 PMID:16868863 PMID:21693461 PMID:21996946 PMID:9797224 Expression of parY(R), which encodes an aminocoumarin resistant topoisomerase IV, can confer aminocoumarin resistance. antibiotic_resistance ARO:3000480 aminocoumarin resistant parY ARO:3000480 Expression of parY(R), which encodes an aminocoumarin resistant topoisomerase IV, can confer aminocoumarin resistance. PMID:12604514 PMID:14993313 PMID:16868863 Tet35 is a tetracycline efflux pump found in the Gram-negative Vibrio and Stenotrophomonas. It is unrelated to other tet resistance genes. effJ tet(35) tet35 antibiotic_resistance ARO:3000481 tet(35) ARO:3000481 Tet35 is a tetracycline efflux pump found in the Gram-negative Vibrio and Stenotrophomonas. It is unrelated to other tet resistance genes. PMID:11897587 tet(35) Telavancin is a semi-synthetic derivative of vancomycin and is a second-generation lipoglycopeptide antibiotic. Telavancin inhibits cell wall synthesis by forming a complex with the D-Ala-D-Ala terminus of peptidoglycan precursors and preventing transglycosylation. CAS:372151-71-8 ChEBI:71229 ChEMBL:CHEMBL507870 PubChem:3081362 antibiotic_resistance ARO:3000488 telavancin ARO:3000488 Telavancin is a semi-synthetic derivative of vancomycin and is a second-generation lipoglycopeptide antibiotic. Telavancin inhibits cell wall synthesis by forming a complex with the D-Ala-D-Ala terminus of peptidoglycan precursors and preventing transglycosylation. PMID:18671473 PMID:19401479 PMID:19436839 Sav1866 is a multidrug efflux pump in the Gram-positive Staphylococcus aureus. It is a homolog of the human ABC transporter Mdr1 and pumps out toxic compounds including verapamil, tetraphenylphosphorchloride, and Hoechst 33342. PDB:2HYD sav1866 antibiotic_resistance ARO:3000489 sav1866 ARO:3000489 Sav1866 is a multidrug efflux pump in the Gram-positive Staphylococcus aureus. It is a homolog of the human ABC transporter Mdr1 and pumps out toxic compounds including verapamil, tetraphenylphosphorchloride, and Hoechst 33342. PMID:16943773 PMID:17303126 sav1866 Tuberactinomycins are a family of cyclic peptide antibiotics that are important in the treatment of tuberculosis. Tuberactinomycins contain nonproteinogenic amino acids and inhibit group I self-splicing RNA to disrupt prokaryotic protein synthesis. PubChem:24847446 antibiotic_resistance ARO:3000490 tuberactinomycin ARO:3000490 Tuberactinomycins are a family of cyclic peptide antibiotics that are important in the treatment of tuberculosis. Tuberactinomycins contain nonproteinogenic amino acids and inhibit group I self-splicing RNA to disrupt prokaryotic protein synthesis. PMID:12936980 PMID:7509881 AcrD is an aminoglycoside efflux pump expressed in E. coli. Its expression can be induced by indole, and is regulated by baeRS and cpxAR. acrD antibiotic_resistance ARO:3000491 acrD ARO:3000491 AcrD is an aminoglycoside efflux pump expressed in E. coli. Its expression can be induced by indole, and is regulated by baeRS and cpxAR. PMID:10692383 acrD Genes that are involved in conferring self resistance to antibiotic. antibiotic_resistance ARO:3000492 gene involved in self-resistance to antibiotic ARO:3000492 Genes that are involved in conferring self resistance to antibiotic. PMID:16186494 ErmD confers MLSb phenotype. ErmD ermJ ermK antibiotic_resistance ARO:3000495 ErmD ARO:3000495 ErmD confers MLSb phenotype. PMID:26650381 ErmD VanXY is a protein with both D,D-carboxypeptidase and D,D-dipeptidase activity, found in Enterococcus gallinarum. It cleaves and removes the terminal D-Ala of peptidoglycan subunits for the incorporation of D-Ser by VanC. D-Ala-D-Ser has low binding affinity with vancomycin. antibiotic_resistance ARO:3000496 vanXY ARO:3000496 VanXY is a protein with both D,D-carboxypeptidase and D,D-dipeptidase activity, found in Enterococcus gallinarum. It cleaves and removes the terminal D-Ala of peptidoglycan subunits for the incorporation of D-Ser by VanC. D-Ala-D-Ser has low binding affinity with vancomycin. PMID:10564477 Ethambutol is an antimycobacterial drug prescribed to treat tuberculosis. It is usually given in combination with other tuberculosis drugs, such as isoniazid, rifampicin, and pyrazinamide. Ethambutol inhibits arabinosyl biosynthesis, disrupting mycobacterial cell wall formation. CAS:74-55-5 ChEBI:4877 ChEMBL:CHEMBL44884 PubChem:14052 antibiotic_resistance ARO:3000497 ethambutol ARO:3000497 Ethambutol is an antimycobacterial drug prescribed to treat tuberculosis. It is usually given in combination with other tuberculosis drugs, such as isoniazid, rifampicin, and pyrazinamide. Ethambutol inhibits arabinosyl biosynthesis, disrupting mycobacterial cell wall formation. PMID:18242089 ErmF confers the MLSb phenotype. ErmF ermFS ermFU antibiotic_resistance ARO:3000498 ErmF ARO:3000498 ErmF confers the MLSb phenotype. PMID:26219215 ErmF AcrE is a membrane fusion protein, similar to AcrA. AcrE antibiotic_resistance ARO:3000499 AcrE ARO:3000499 AcrE is a membrane fusion protein, similar to AcrA. PMID:16267305 PMID:8407802 AcrE The enzyme responsible for converting phosphonoacetaldehyde to (S)-2-/nhydroxypropylphosphonic acid (S-HPP) via an anionic methyl attack, which also reduces the aldehyde to an alcohol. Fom3 antibiotic_resistance ARO:3000500 phosphonoacetaldehyde methyltransfererase ARO:3000500 The enzyme responsible for converting phosphonoacetaldehyde to (S)-2-/nhydroxypropylphosphonic acid (S-HPP) via an anionic methyl attack, which also reduces the aldehyde to an alcohol. PMID:1468993 PMID:16015285 Due to gene duplication, the genomes of Nocardia species include both rifampin-sensitive beta-subunit of RNA polymerase (rpoB) and rifampin-resistant beta-subunit of RNA polymerase (rpoB2) genes, with ~88% similarity between the two gene products. Expression of the rpoB2 variant results in replacement of rifampin sensitivity with rifampin resistance. rpoB2 antibiotic_resistance ARO:3000501 rpoB2 ARO:3000501 Due to gene duplication, the genomes of Nocardia species include both rifampin-sensitive beta-subunit of RNA polymerase (rpoB) and rifampin-resistant beta-subunit of RNA polymerase (rpoB2) genes, with ~88% similarity between the two gene products. Expression of the rpoB2 variant results in replacement of rifampin sensitivity with rifampin resistance. PMID:16569850 rpoB2 AcrF is a inner membrane transporter, similar to AcrB. AcrF antibiotic_resistance ARO:3000502 AcrF ARO:3000502 AcrF is a inner membrane transporter, similar to AcrB. PMID:16267305 AcrF AcrEF-TolC is a tripartite multidrug efflux system similar to AcrAB-TolC and found in Gram-negative bacteria. AcrE is the membrane fusion protein, AcrF is the inner membrane transporter, and TolC is the outer membrane channel protein. EnvCD-TolC antibiotic_resistance ARO:3000503 AcrEF-TolC ARO:3000503 AcrEF-TolC is a tripartite multidrug efflux system similar to AcrAB-TolC and found in Gram-negative bacteria. AcrE is the membrane fusion protein, AcrF is the inner membrane transporter, and TolC is the outer membrane channel protein. PMID:12937021 PMID:16267305 PMID:1720861 PMID:18984645 PMID:8647368 GolS is a regulator activated by the presence of golD, and promotes the expression of the MdsABC efflux pump. golS antibiotic_resistance ARO:3000504 golS ARO:3000504 GolS is a regulator activated by the presence of golD, and promotes the expression of the MdsABC efflux pump. PMID:17919284 PMID:20807206 golS MexR is the repressor of the MexRAB-OprM operon. Mutant forms of mexR result in up-regulation of efflux pump system MexAB-OprM. PDB:1LNW MexR nalB antibiotic_resistance ARO:3000506 MexR ARO:3000506 MexR is the repressor of the MexRAB-OprM operon. Mutant forms of mexR result in up-regulation of efflux pump system MexAB-OprM. PMID:12727072 PMID:14526032 PMID:18812515 PMID:20616806 MexR Proteins which have been experimentally shown to protect RNA-polymerase from rifampin inhibition. antibiotic_resistance ARO:3000507 rifampin-resistant RNA polymerase-binding protein ARO:3000507 GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. gadX antibiotic_resistance ARO:3000508 gadX ARO:3000508 GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. PMID:18297445 gadX An alternative isoleucyl-tRNA synthetase conferring resistance to mupirocin. Saur_mupB_MUP antibiotic_resistance ARO:3000510 Staphylococcus aureus mupB conferring resistance to mupirocin ARO:3000510 An alternative isoleucyl-tRNA synthetase conferring resistance to mupirocin. PMID:22252810 Saur_mupB_MUP EvgSA is a two-component regulatory system that regulates MdtEF and EmrKY expression for multidrug resistance. EvgS is a sensor protein that phosphorylates the regulatory protein EvgA, though EvgA can be phosphorylated by other methods when it is overexpressed. antibiotic_resistance ARO:3000515 evgSA ARO:3000515 EvgSA is a two-component regulatory system that regulates MdtEF and EmrKY expression for multidrug resistance. EvgS is a sensor protein that phosphorylates the regulatory protein EvgA, though EvgA can be phosphorylated by other methods when it is overexpressed. PMID:11914367 EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. emrR mprA antibiotic_resistance ARO:3000516 emrR ARO:3000516 EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. PMID:7730261 emrR Rifaximin is a semi-synthetic rifamycin used to treat traveller's diarrhea. Rifaximin inhibits RNA synthesis by binding to the beta subunit of bacterial RNA polymerase. CAS:80621-81-4 ChEBI:75246 ChEMBL:CHEMBL1617 PubChem:6436173 antibiotic_resistance ARO:3000517 rifaximin ARO:3000517 Rifaximin is a semi-synthetic rifamycin used to treat traveller's diarrhea. Rifaximin inhibits RNA synthesis by binding to the beta subunit of bacterial RNA polymerase. PMID:15667909 CRP is a global regulator that represses MdtEF multidrug efflux pump expression. CRP antibiotic_resistance ARO:3000518 CRP ARO:3000518 CRP is a global regulator that represses MdtEF multidrug efflux pump expression. PMID:18503189 CRP Enzymes that confer resistance by modifying antibiotic targets. antibiotic_resistance ARO:3000519 antibiotic target modifying enzyme ARO:3000519 Isoniazid is an organic compound that is the first-line anti tuberculosis medication in prevention and treatment. As a prodrug, it is activated by mycobacterial catalase-peroxidases such as M. tuberculosis KatG. Isoniazid inhibits mycolic acid synthesis, which prevents cell wall synthesis in mycobacteria. CAS:54-85-3 ChEBI:6030 ChEMBL:CHEMBL64 PubChem:3767 antibiotic_resistance ARO:3000520 isoniazid ARO:3000520 Isoniazid is an organic compound that is the first-line anti tuberculosis medication in prevention and treatment. As a prodrug, it is activated by mycobacterial catalase-peroxidases such as M. tuberculosis KatG. Isoniazid inhibits mycolic acid synthesis, which prevents cell wall synthesis in mycobacteria. PMID:19139099 PMID:8143118 An alternative isoleucyl-tRNA synthetase conferring resistance to mupirocin. Saur_mupA_MUP ileS2 antibiotic_resistance ARO:3000521 Staphylococcus aureus mupA conferring resistance to mupirocin ARO:3000521 An alternative isoleucyl-tRNA synthetase conferring resistance to mupirocin. PMID:11599741 PMID:21421794 PMID:8067768 Saur_mupA_MUP ErmG is a rRNA adenine N-6-methyltransferase that protects the ribosome from inactivation due to antibiotic binding. ErmG antibiotic_resistance ARO:3000522 ErmG ARO:3000522 ErmG is a rRNA adenine N-6-methyltransferase that protects the ribosome from inactivation due to antibiotic binding. PMID:3025178 ErmG CpxAR is a two-component regulatory system that involves a sensor kinase, CpxA, and the regulator CpxR. When the membrane envelope is stressed, CpxAR promotes acrD and mdtABC expression to confer multidrug resistance through efflux. antibiotic_resistance ARO:3000524 cpxAR ARO:3000524 CpxAR is a two-component regulatory system that involves a sensor kinase, CpxA, and the regulator CpxR. When the membrane envelope is stressed, CpxAR promotes acrD and mdtABC expression to confer multidrug resistance through efflux. PMID:12618449 PMID:22496764 A40926 is a glycopeptide antibiotic produced by Nonomuraea sp. ATCC 39727. It is precusor of the second-generation glycopeptide antibiotic dalbavancin. ChEMBL:CHEMBL1142788 PubChem:16133962 antibiotic_resistance ARO:3000525 antibiotic A40926 ARO:3000525 A40926 is a glycopeptide antibiotic produced by Nonomuraea sp. ATCC 39727. It is precusor of the second-generation glycopeptide antibiotic dalbavancin. PMID:12837387 PMID:15664522 CmeR is a repressor for the CmeABC multidrug efflux pump, binding to the cmeABC promoter region. cmeR antibiotic_resistance ARO:3000526 cmeR ARO:3000526 CmeR is a repressor for the CmeABC multidrug efflux pump, binding to the cmeABC promoter region. PMID:15728904 cmeR Polyamine antibiotics are organic compounds having two or more primary amino groups. antibiotic_resistance ARO:3000527 polyamine antibiotic ARO:3000527 Chlortetracycline was an early, first-generation tetracycline antibiotic developed in the 1940's. It inhibits bacterial protein synthesis by binding to the 30S subunit of bacterial ribosomes, preventing the aminoacyl-tRNA from binding to the ribosome. CAS:57-62-5 ChEBI:27644 ChEMBL:CHEMBL404520 PubChem:54675777 Aureomycin Eremomycine antibiotic_resistance ARO:3000528 chlortetracycline ARO:3000528 Chlortetracycline was an early, first-generation tetracycline antibiotic developed in the 1940's. It inhibits bacterial protein synthesis by binding to the 30S subunit of bacterial ribosomes, preventing the aminoacyl-tRNA from binding to the ribosome. PMID:11381101 PMID:19862477 Rifabutin is a semisynthetic rifamycin used in tuberculosis therapy. It inhibits DNA-dependent RNA synthesis. CAS:72559-06-9 ChEBI:45367 ChEMBL:CHEMBL444633 PubChem:135398743 antibiotic_resistance ARO:3000530 rifabutin ARO:3000530 Rifabutin is a semisynthetic rifamycin used in tuberculosis therapy. It inhibits DNA-dependent RNA synthesis. PMID:15700959 BaeSR is a two component regulatory system for efflux proteins in Gram-negative bacteria. BaeR is a response regulator, while BaeS is a sensor kinase. antibiotic_resistance ARO:3000531 baeSR ARO:3000531 BaeSR is a two component regulatory system for efflux proteins in Gram-negative bacteria. BaeR is a response regulator, while BaeS is a sensor kinase. PMID:12107134 PMID:15716448 Biosynthesis of aminocoumarin antibiotics. antibiotic_resistance ARO:3000532 aminocoumarin biosynthesis ARO:3000532 Biosynthesis of aminocoumarin antibiotics. PMID:16868863 MacA is a membrane fusion protein that forms an antibiotic efflux complex with MacB and TolC. macA corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. PDB:3FPP macA pvdR antibiotic_resistance ARO:3000533 macA ARO:3000533 MacA is a membrane fusion protein that forms an antibiotic efflux complex with MacB and TolC. macA corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. PMID:19254725 PMID:20307498 macA Rifapentine is a semisynthetic rifamycin that inhibits DNA-dependent RNA synthesis. It is often used in the treatment of tuberculosis and leprosy. CAS:61379-65-5 ChEBI:45304 ChEMBL:CHEMBL1660 PubChem:135403821 priftin antibiotic_resistance ARO:3000534 rifapentine ARO:3000534 Rifapentine is a semisynthetic rifamycin that inhibits DNA-dependent RNA synthesis. It is often used in the treatment of tuberculosis and leprosy. PMID:15700959 MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC. macB corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. PDB:3FTJ macB pvdT antibiotic_resistance ARO:3000535 macB ARO:3000535 MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC. macB corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. PMID:12832048 PMID:16359323 PMID:19432486 macB Novobiocin is produced from biosynthetic clusters in Streptomyces spheroides and Streptomyces niveus. antibiotic_resistance ARO:3000536 Streptomyces spheroides novobiocin biosynthetic gene cluster ARO:3000536 Novobiocin is produced from biosynthetic clusters in Streptomyces spheroides and Streptomyces niveus. PMID:10770754 PMID:10801869 MacAB-TolC is an ABC efflux pump complex expressed in E. coli and Salmonella enterica. It confers resistance to macrolides, including erythromycin. antibiotic_resistance ARO:3000545 MacAB-TolC ARO:3000545 MacAB-TolC is an ABC efflux pump complex expressed in E. coli and Salmonella enterica. It confers resistance to macrolides, including erythromycin. PMID:16359323 Clorobiocin is produced by a biosynthetic cluster in Streptomyces roseochromogenus subsp. oscitans. antibiotic_resistance ARO:3000546 Streptomyces roseochromogenus subsp. oscitans clorobiocin biosynthetic gene cluster ARO:3000546 Clorobiocin is produced by a biosynthetic cluster in Streptomyces roseochromogenus subsp. oscitans. PMID:12480894 PMID:16868863 ArlRS is a two-component regulatory system for NorA. ArlS phosphorylates ArlR to promote NorA expression. antibiotic_resistance ARO:3000547 arlRS ARO:3000547 ArlRS is a two-component regulatory system for NorA. ArlS phosphorylates ArlR to promote NorA expression. PMID:10633099 Coumermycin A1 is produced by a biosynthetic cluster in Streptomyces rishiriensis. antibiotic_resistance ARO:3000548 Streptomyces rishiriensis strain DSM 40489 coumermycin A1 biosynthetic gene cluster ARO:3000548 Coumermycin A1 is produced by a biosynthetic cluster in Streptomyces rishiriensis. PMID:11036020 PMID:16868863 AdeS is a sensor kinase in the AdeRS regulatory system of AdeABC. It is essential for AdeABC expression. adeS antibiotic_resistance ARO:3000549 adeS ARO:3000549 AdeS is a sensor kinase in the AdeRS regulatory system of AdeABC. It is essential for AdeABC expression. PMID:22371895 adeS Aztreonam was the first monobactam discovered, and is greatly effective against Gram-negative bacteria while inactive against Gram-positive bacteria. Artreonam is a poor substrate for beta-lactamases, and may even act as an inhibitor. In Gram-negative bacteria, Aztreonam interferes with filamentation, inhibiting cell division and leading to cell death. CAS:78110-38-0 ChEBI:161680 ChEMBL:CHEMBL158 PubChem:5742832 AZT Azactam Primbactam antibiotic_resistance ARO:3000550 aztreonam ARO:3000550 Aztreonam was the first monobactam discovered, and is greatly effective against Gram-negative bacteria while inactive against Gram-positive bacteria. Artreonam is a poor substrate for beta-lactamases, and may even act as an inhibitor. In Gram-negative bacteria, Aztreonam interferes with filamentation, inhibiting cell division and leading to cell death. PMID:3871589 Organoarsenic antibiotics are arsenic-containing compounds with antibacterial effects. The organoarsenic antibiotic arsphenamine and its derivatives were developed in the 1910s as the first modern chemotherapeutic agents. Salvarsan arsenical antibiotic_resistance ARO:3000551 organoarsenic antibiotic ARO:3000551 Arsphenamine, also known as Salvarsan and 606, is a drug that was used beginning in the 1910s to treat syphilis and trypanosomiasis. It is an organoarsenic compound and was the first modern chemotherapeutic agent. CAS:139-93-5 ChEBI:9016 PubChem:8774 Salvarsan antibiotic_resistance ARO:3000552 arsphenamine ARO:3000552 Arsphenamine, also known as Salvarsan and 606, is a drug that was used beginning in the 1910s to treat syphilis and trypanosomiasis. It is an organoarsenic compound and was the first modern chemotherapeutic agent. PMID:18679046 AdeR is a positive regulator of AdeABC efflux system. AdeR inactivation leads to susceptibility to aminoglycoside antibiotics. adeR antibiotic_resistance ARO:3000553 adeR ARO:3000553 AdeR is a positive regulator of AdeABC efflux system. AdeR inactivation leads to susceptibility to aminoglycoside antibiotics. PMID:22371895 adeR Mupirocin, also known as pseudomonic acid, is a bacteriostatic polyketide antibiotic from Pseudomonas fluorescens used to treat S. aureus and MRSA. It inhibits Ile tRNA synthetase. CAS:12650-69-0 ChEBI:7025 ChEMBL:CHEMBL719 PubChem:446596 pseudomonic acid antibiotic_resistance ARO:3000554 mupirocin ARO:3000554 Mupirocin, also known as pseudomonic acid, is a bacteriostatic polyketide antibiotic from Pseudomonas fluorescens used to treat S. aureus and MRSA. It inhibits Ile tRNA synthetase. PMID:21336932 Biosynthesis of macrolide antibiotics. antibiotic_resistance ARO:3000555 macrolide biosynthesis ARO:3000555 Tet44 is a tetracycline resistance gene found in Campylobacter fetus, and binds to the ribosome to confer antibiotic resistance as a ribosomal protection protein. tet(44) antibiotic_resistance ARO:3000556 tet(44) ARO:3000556 Tet44 is a tetracycline resistance gene found in Campylobacter fetus, and binds to the ribosome to confer antibiotic resistance as a ribosomal protection protein. PMID:20479200 tet(44) Enzyme that catalyzes the inactivation of an antibiotic resulting in resistance. Inactivation includes chemical modification, destruction, etc. antibiotic_resistance ARO:3000557 antibiotic inactivation enzyme ARO:3000557 AdeN is a repressor of AdeIJK, a RND-type efflux pump in Acinetobacter baumannii. Its inactivation increases expression of AdeJ. adeN antibiotic_resistance ARO:3000559 adeN ARO:3000559 AdeN is a repressor of AdeIJK, a RND-type efflux pump in Acinetobacter baumannii. Its inactivation increases expression of AdeJ. PMID:22371895 adeN Erm proteins are part of the RNA methyltransferase family and methylate A2058 (E. coli nomenclature) of the 23S ribosomal RNA conferring degrees of resistance to Macrolides, Lincosamides and Streptogramin b. This is called the MLSb phenotype. antibiotic_resistance ARO:3000560 Erm 23S ribosomal RNA methyltransferase ARO:3000560 Erm proteins are part of the RNA methyltransferase family and methylate A2058 (E. coli nomenclature) of the 23S ribosomal RNA conferring degrees of resistance to Macrolides, Lincosamides and Streptogramin b. This is called the MLSb phenotype. PMID:10582867 PMID:20618865 Tet30 is a tetracycline efflux pump found in agrobacterium, a Gram-negative bacterium. tet(30) tet30 antibiotic_resistance ARO:3000561 tet(30) ARO:3000561 Tet30 is a tetracycline efflux pump found in agrobacterium, a Gram-negative bacterium. PMID:11381101 PMID:9882678 tet(30) Tet38 is a tetracycline efflux pump found in the Gram-positive Staphylococcus aureus. It is regulated by mgrA, which also regulates NorB. tet(38) tet38 antibiotic_resistance ARO:3000565 tet(38) ARO:3000565 Tet38 is a tetracycline efflux pump found in the Gram-positive Staphylococcus aureus. It is regulated by mgrA, which also regulates NorB. PMID:15774883 tet(38) Tet39 is a tetracycline efflux pump found in Gram-negative bacteria, including Brevundimonas, Stenotrophomonas, Enterobacter, Alcaligenes, Acinetobacter, and Providencia. tet(39) tet39 tetA(39) antibiotic_resistance ARO:3000566 tet(39) ARO:3000566 Tet39 is a tetracycline efflux pump found in Gram-negative bacteria, including Brevundimonas, Stenotrophomonas, Enterobacter, Alcaligenes, Acinetobacter, and Providencia. PMID:15761075 tet(39) Tet40 is a tetracycline efflux pump found in the Gram-positive Clostridium. It is similar to tetA(P). tet(40) tet40 antibiotic_resistance ARO:3000567 tet(40) ARO:3000567 Tet40 is a tetracycline efflux pump found in the Gram-positive Clostridium. It is similar to tetA(P). PMID:18779355 tet(40) Subclass B1 possess a binuclear active site. Within this active site can be either one or two Zn(II) ions. This subclass is able to hydrolyze penicillins, cephalosporins and carbapenems. This is the most clinically relevant subclass of MBLs. antibiotic_resistance ARO:3000568 subclass B1 (metallo-) beta-lactamase ARO:3000568 Subclass B1 possess a binuclear active site. Within this active site can be either one or two Zn(II) ions. This subclass is able to hydrolyze penicillins, cephalosporins and carbapenems. This is the most clinically relevant subclass of MBLs. PMID:18563261 Tet41 is a tetracycline efflux pump found in Serratia, a Gram-negative bacterium. It is related to Acinetobacter Tet(39). tet(41) tet41 tetA(41) antibiotic_resistance ARO:3000569 tet(41) ARO:3000569 Tet41 is a tetracycline efflux pump found in Serratia, a Gram-negative bacterium. It is related to Acinetobacter Tet(39). PMID:17308196 tet(41) Metallo-beta-lactmases of subclass B2 contain only one Zn ion in their active site and selectively hydrolyze carbapenems. antibiotic_resistance ARO:3000570 subclass B2 (metallo-) beta-lactamase ARO:3000570 Metallo-beta-lactamases of subclass B3 are similar to B1 in that they have activity against penicillins, cephalosporins and carbapenems; however, the are only active with two Zn(II) ions in the active site. antibiotic_resistance ARO:3000571 subclass B3 (metallo-) beta-lactamase ARO:3000571 Metallo-beta-lactamases of subclass B3 are similar to B1 in that they have activity against penicillins, cephalosporins and carbapenems; however, the are only active with two Zn(II) ions in the active site. PMID:18563261 Tet42 is a tetracycline efflux pump found in both Gram-negative (Pseudomonas) and Gram-positive (Microbacterium, Bacillus, Staphylococcus, Paenibacillus) bacteria. tet(42) tet42 tetA(42) antibiotic_resistance ARO:3000572 tet(42) ARO:3000572 Tet42 is a tetracycline efflux pump found in both Gram-negative (Pseudomonas) and Gram-positive (Microbacterium, Bacillus, Staphylococcus, Paenibacillus) bacteria. PMID:18809935 tet(42) Tet(43) is a tetracycline resistance gene with unknown origins, isolated from metagenomic DNA. tet(43) tet43 antibiotic_resistance ARO:3000573 tet(43) ARO:3000573 Tet(43) is a tetracycline resistance gene with unknown origins, isolated from metagenomic DNA. PMID:11381101 tet(43) VanR is a OmpR-family transcriptional activator in the VanSR regulatory system. When activated by VanS, it promotes cotranscription of VanA, VanH, and VanX. antibiotic_resistance ARO:3000574 vanR ARO:3000574 VanR is a OmpR-family transcriptional activator in the VanSR regulatory system. When activated by VanS, it promotes cotranscription of VanA, VanH, and VanX. PMID:1556077 VanU is a transcriptional activator of vancomycin resistance genes. antibiotic_resistance ARO:3000575 vanU ARO:3000575 VanU is a transcriptional activator of vancomycin resistance genes. PMID:11036060 PMID:14617152 Enzymes that inactivate rifampin antibiotics by chemical modification. antibiotic_resistance ARO:3000576 rifampin inactivation enzyme ARO:3000576 Subclass B1 Bacillus cereus Bc beta-lactamases are zinc metallo-beta-lactamases that hydrolyze a large number of penicillins and cephalosporins. antibiotic_resistance ARO:3000577 subclass B1 Bacillus cereus Bc beta-lactamase ARO:3000577 Subclass B1 Bacillus cereus Bc beta-lactamases are zinc metallo-beta-lactamases that hydrolyze a large number of penicillins and cephalosporins. PMID:7588620 CcrA is a CfiA beta-lactamase. CciA CcrA antibiotic_resistance ARO:3000578 CcrA ARO:3000578 CcrA is a CfiA beta-lactamase. PMID:1510410 CcrA This BlaB specific to Chryseobacterium meningosepticum mediates resistance against many beta-lactam antibiotics, notably penams and carbapenems. Cmen_BlaB antibiotic_resistance ARO:3000579 Chryseobacterium meningosepticum BlaB ARO:3000579 This BlaB specific to Chryseobacterium meningosepticum mediates resistance against many beta-lactam antibiotics, notably penams and carbapenems. PMID:12019109 Cmen_BlaB Sao Paulo metallo-beta-lactamase (SPM-1) confers resistance to carbapenem in Pseudomonas aeruginosa. antibiotic_resistance ARO:3000580 SPM beta-lactamase ARO:3000580 Sao Paulo metallo-beta-lactamase (SPM-1) confers resistance to carbapenem in Pseudomonas aeruginosa. PMID:12407123 PMID:12951331 PMID:16239284 CphA is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas hydrophilia. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein. antibiotic_resistance ARO:3000581 CphA beta-lactamase ARO:3000581 CphA is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas hydrophilia. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein. PMID:18563261 L1 is an Ambler class B MBL; subclass B3 originally isolated from Stenotrophomonas maltophilia. It has activity against a broad range of beta-lactams and is only active with two Zn(II) ions in the active site. PDB:2QDT L1_BLA antibiotic_resistance ARO:3000582 L1 beta-lactamase ARO:3000582 L1 is an Ambler class B MBL; subclass B3 originally isolated from Stenotrophomonas maltophilia. It has activity against a broad range of beta-lactams and is only active with two Zn(II) ions in the active site. PMID:18563261 L1_BLA Pristinamycin IA is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains. ChEBI:8417 ChEMBL:CHEMBL1256399 PubChem:11136668 Virginiamycin B antibiotic_resistance ARO:3000583 pristinamycin IA ARO:3000583 Quinupristin is a type B streptogramin and a semisynthetic derivative of pristinamycin 1A. It is a component of the drug Synercid and interacts with the 50S subunit of the bacterial ribosome to inhibit protein synthesis. ChEBI:8732 ChEMBL:CHEMBL1200649 PubChem:5388937 antibiotic_resistance ARO:3000584 quinupristin ARO:3000584 Quinupristin is a type B streptogramin and a semisynthetic derivative of pristinamycin 1A. It is a component of the drug Synercid and interacts with the 50S subunit of the bacterial ribosome to inhibit protein synthesis. PMID:15700955 PMID:9746015 Pulvomycin is a polyketide antibiotic that binds elongation factor Tu (EF-Tu) to inhibit protein biosynthesis by preventing the formation of the ternary complex (EF-Tu*GTP*aa-tRNA). Phenotypically, it was shown that pulvomycin sensitivity is dominant over resistance. CAS:11006-66-9 ChEBI:29668 PubChem:5282056 Labilomycin antibiotic_resistance ARO:3000586 pulvomycin ARO:3000586 Pulvomycin is a polyketide antibiotic that binds elongation factor Tu (EF-Tu) to inhibit protein biosynthesis by preventing the formation of the ternary complex (EF-Tu*GTP*aa-tRNA). Phenotypically, it was shown that pulvomycin sensitivity is dominant over resistance. PMID:15581367 PMID:16734421 PMID:364475 PMID:7957075 Sulbactam is an inhibitor of non-AmpC serine beta-lactamases. CAS:68373-14-8 ChEBI:9321 ChEMBL:CHEMBL403 PubChem:130313 antibiotic_resistance ARO:3000587 sulbactam ARO:3000587 Serine beta-lactamase inhibitor targeting class A, class C, and some class D enzymes. CAS:1192500-31-4 ChEBI:85984 ChEMBL:CHEMBL1689063 PubChem:24944097 NXL-104 antibiotic_resistance ARO:3000588 avibactam ARO:3000588 Serine beta-lactamase inhibitor targeting class A, class C, and some class D enzymes. PMID:20921316 PMID:27480848 PMID:27528799 NDM-1 is a metallo-beta-lactamase isolated from Klebsiella pneumoniae with nearly complete resistance to all beta-lactam antibiotics. PDB:5ZGE NDM-1 antibiotic_resistance ARO:3000589 NDM-1 ARO:3000589 NDM-1 is a metallo-beta-lactamase isolated from Klebsiella pneumoniae with nearly complete resistance to all beta-lactam antibiotics. PMID:19770275 PMID:21507902 PMID:21774017 PMID:24790993 PMID:27575913 PMID:29454953 NDM-1 NDM-2 was isolated from a strain of Acinetobacter baumannii in Germany from a patient hospitalized in Cairo. A single amino acid substitution (P28R) differentiates this gene from NDM-1 and the two enzymes appear to have an identical spectrum of hydrolysis. NDM-2 antibiotic_resistance ARO:3000590 NDM-2 ARO:3000590 NDM-2 was isolated from a strain of Acinetobacter baumannii in Germany from a patient hospitalized in Cairo. A single amino acid substitution (P28R) differentiates this gene from NDM-1 and the two enzymes appear to have an identical spectrum of hydrolysis. PMID:21427107 NDM-2 ErmN is a methyltransferase found in the tylosin producer Streptomyces fradiae. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. Specifically, this enzyme transfers only one methyl group. The gene is found in the tylosin biosynthetic cluster and is responsible for self-resistance to tylosin. ErmN tlrD antibiotic_resistance ARO:3000592 ErmN ARO:3000592 ErmN is a methyltransferase found in the tylosin producer Streptomyces fradiae. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. Specifically, this enzyme transfers only one methyl group. The gene is found in the tylosin biosynthetic cluster and is responsible for self-resistance to tylosin. PMID:12019067 PMID:12417742 PMID:8973363 ErmN ErmQ confers MLSb phenotype. ErmQ antibiotic_resistance ARO:3000593 ErmQ ARO:3000593 ErmQ confers MLSb phenotype. PMID:8067735 ErmQ ErmR is a methyltransferase found in the erythromycin producer Aeromicrobium erythreum. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. The gene is found within the erythromycin biosynthetic cluster and is responsible for self-resistance. ErmR antibiotic_resistance ARO:3000594 ErmR ARO:3000594 ErmR is a methyltransferase found in the erythromycin producer Aeromicrobium erythreum. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. The gene is found within the erythromycin biosynthetic cluster and is responsible for self-resistance. PMID:1768148 ErmR ErmT confers MLSb phenotype. ErmT ermGT antibiotic_resistance ARO:3000595 ErmT ARO:3000595 ErmT confers MLSb phenotype. PMID:8171126 ErmT ErmX is a rRNA methyltransferase that protects the ribosome from inactivation due to antibiotic binding. ErmX ermCD ermCX antibiotic_resistance ARO:3000596 ErmX ARO:3000596 ErmX is a rRNA methyltransferase that protects the ribosome from inactivation due to antibiotic binding. PMID:11408212 ErmX Erm(31) confers a MLSb resistant phenotype. Along with erm(30), these genes are responsible for self-resistance in the pikromycin/narbomycin/methymycin/neomethymycin producer, Streptomyces venezuelae. Erm(31) Erm31 antibiotic_resistance ARO:3000598 Erm(31) ARO:3000598 Erm(31) confers a MLSb resistant phenotype. Along with erm(30), these genes are responsible for self-resistance in the pikromycin/narbomycin/methymycin/neomethymycin producer, Streptomyces venezuelae. PMID:14674753 PMID:9770448 Erm(31) ErmD confers MLSb phenotype. Erm(33) Erm33 antibiotic_resistance ARO:3000599 Erm(33) ARO:3000599 ErmD confers MLSb phenotype. PMID:12384375 Erm(33) ErmD confers MLSb phenotype. Erm(34) Erm34 antibiotic_resistance ARO:3000600 Erm(34) ARO:3000600 ErmD confers MLSb phenotype. PMID:14711653 Erm(34) ErmD confers MLSb phenotype. Erm(38) Erm38 antibiotic_resistance ARO:3000601 Erm(38) ARO:3000601 ErmD confers MLSb phenotype. PMID:16127056 Erm(38) ErmD confers MLSb phenotype. Erm(39) Erm39 antibiotic_resistance ARO:3000602 Erm(39) ARO:3000602 ErmD confers MLSb phenotype. PMID:15590712 Erm(39) Erm41 confers MLSb phenotype. Erm(41) Erm41 antibiotic_resistance ARO:3000603 Erm(41) ARO:3000603 Erm41 confers MLSb phenotype. PMID:27244062 Erm(41) ErmD confers MLSb phenotype. Erm(35) Erm35 antibiotic_resistance ARO:3000604 Erm(35) ARO:3000604 ErmD confers MLSb phenotype. PMID:1804017 Erm(35) ErmD confers MLSb phenotype. Erm(36) Erm36 antibiotic_resistance ARO:3000605 Erm(36) ARO:3000605 ErmD confers MLSb phenotype. PMID:12177341 Erm(36) FEZ-1 is an Ambler class B MBL; subclass B3 first isolated from Legionella gormanii. It has activity against a broad range of beta-lactams and is only active with two Zn(II) ions in the active site. FEZ-1 antibiotic_resistance ARO:3000606 FEZ-1 ARO:3000606 FEZ-1 is an Ambler class B MBL; subclass B3 first isolated from Legionella gormanii. It has activity against a broad range of beta-lactams and is only active with two Zn(II) ions in the active site. PMID:12507470 PMID:18563261 FEZ-1 Many genes involved in antibiotic resistance are mobile and microarray probes for these genes can thus provide positive results for any number of organisms. CARD stores the coding sequences of genes targeted by the probe sets of available antibiotic resistance microarrays. antibiotic_resistance ARO:3000610 gene detected by antibiotic resistance screening microarray ARO:3000610 Many genes involved in antibiotic resistance are mobile and microarray probes for these genes can thus provide positive results for any number of organisms. CARD stores the coding sequences of genes targeted by the probe sets of available antibiotic resistance microarrays. PMID:20035807 PMID:20356716 mef(E) is a proton motive efflux pump in Streptococcus pneumoniae that confers resistance to macrolides. It is found on the same operon as mefA and the ABC-efflux pump mel. mef(E) mefE antibiotic_resistance ARO:3000614 mef(E) ARO:3000614 mef(E) is a proton motive efflux pump in Streptococcus pneumoniae that confers resistance to macrolides. It is found on the same operon as mefA and the ABC-efflux pump mel. PMID:16189099 mef(E) Mel, a homolog of MsrA, is an ABC-F subfamily protein associated with macrolide resistance. It is expressed on the same operon as mefA and mefE, both MFS-type efflux proteins that confer macrolide resistance. mefA mel msr(D) msrD antibiotic_resistance ARO:3000616 mel ARO:3000616 Mel, a homolog of MsrA, is an ABC-F subfamily protein associated with macrolide resistance. It is expressed on the same operon as mefA and mefE, both MFS-type efflux proteins that confer macrolide resistance. PMID:16189099 PMID:22137270 PMID:23114767 mel A foreign PBP2a acquired by lateral gene transfer that is able to perform peptidoglycan synthesis in the presence of beta-lactams. PBP2A mecA antibiotic_resistance ARO:3000617 mecA ARO:3000617 A foreign PBP2a acquired by lateral gene transfer that is able to perform peptidoglycan synthesis in the presence of beta-lactams. PMID:12389036 PMID:15226303 PMID:18718557 PMID:21636525 PMID:21931689 PMID:2708325 PMID:27547406 PMID:3878127 PMID:6563036 mecA ParC is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Point mutations in ParC prevent fluoroquinolone antibiotics from inhibiting DNA synthesis, and confer low-level resistance. Higher-level resistance results from both gyrA and parC mutations. antibiotic_resistance ARO:3000619 fluoroquinolone resistant parC ARO:3000619 ParC is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Point mutations in ParC prevent fluoroquinolone antibiotics from inhibiting DNA synthesis, and confer low-level resistance. Higher-level resistance results from both gyrA and parC mutations. PMID:18471102 PMID:8913454 PMID:9293187 AdeL is a regulator of AdeFGH in Acinetobacter baumannii. AdeL mutations are associated with AdeFGH overexpression and multidrug resistance. adeL antibiotic_resistance ARO:3000620 adeL ARO:3000620 AdeL is a regulator of AdeFGH in Acinetobacter baumannii. AdeL mutations are associated with AdeFGH overexpression and multidrug resistance. PMID:20696879 adeL The blaZ beta-lactamase is found in Bacillus subtilis and Staphylococcus aureus. PDB:3BLM PC1_blaZ antibiotic_resistance ARO:3000621 PC1 beta-lactamase (blaZ) ARO:3000621 The blaZ beta-lactamase is found in Bacillus subtilis and Staphylococcus aureus. PMID:17986343 PMID:6793593 PC1_blaZ Colistin A, or polymyxin E1, has a 6-octanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria. ChEBI:59064 PubChem:202195 polymyxin E1 antibiotic_resistance ARO:3000622 colistin A ARO:3000622 Colistin A, or polymyxin E1, has a 6-octanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria. PMID:19157746 PMID:20818945 Colistin B, or polymyxin E2, has a 6-heptanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria. ChEBI:59673 ChEMBL:CHEMBL1089240 PubChem:25138298 polymyxin E2 antibiotic_resistance ARO:3000624 colistin B ARO:3000624 Colistin B, or polymyxin E2, has a 6-heptanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria. PMID:19157746 PMID:20818945 Polymyxin B1 is in the family of polymyxin lipopeptides with a 6-methyloctanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria. ChEBI:8309 PubChem:199402 antibiotic_resistance ARO:3000625 polymyxin B1 ARO:3000625 Polymyxin B1 is in the family of polymyxin lipopeptides with a 6-methyloctanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria. PMID:11330807 Polymyxin B2 is in the family of polymyxin lipopeptides with a 6-methylheptanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria. CAS:1404-26-8 ChEBI:59063 ChEMBL:CHEMBL1088938 PubChem:11982455 antibiotic_resistance ARO:3000626 polymyxin B2 ARO:3000626 Polymyxin B2 is in the family of polymyxin lipopeptides with a 6-methylheptanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria. PMID:11330807 Polymyxin B3 is in the family of polymyxin lipopeptides with an octanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria. ChEMBL:CHEMBL2021599 PubChem:46883542 antibiotic_resistance ARO:3000627 polymyxin B3 ARO:3000627 Polymyxin B3 is in the family of polymyxin lipopeptides with an octanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria. PMID:11330807 Polymyxin B4 is in the family of polymyxin lipopeptides with a heptanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria. ChEMBL:CHEMBL1088940 PubChem:46883543 antibiotic_resistance ARO:3000628 polymyxin B4 ARO:3000628 Polymyxin B4 is in the family of polymyxin lipopeptides with a heptanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria. PMID:11330807 Bacitracin A is the primary component of bacitracin. It contains many uncommon amino acids and interferes with bacterial cell wall synthesis. ChEBI:35862 ChEMBL:CHEMBL1790520 PubChem:10909430 antibiotic_resistance ARO:3000629 bacitracin A ARO:3000629 Bacitracin A is the primary component of bacitracin. It contains many uncommon amino acids and interferes with bacterial cell wall synthesis. PMID:6752975 Bacitracin B is a component of bacitracin, an antibiotic mixture that interferes with bacterial cell wall synthesis. It differs from Bacitracin A with a valine instead of an isoleucine in its peptide. PubChem:121232829 antibiotic_resistance ARO:3000630 bacitracin B ARO:3000630 Bacitracin B is a component of bacitracin, an antibiotic mixture that interferes with bacterial cell wall synthesis. It differs from Bacitracin A with a valine instead of an isoleucine in its peptide. PMID:6752975 Bacitracin F is a component of bacitracin, an antibiotic mixture that interferes with bacterial cell wall synthesis. It is formed when the thiazoline ring of bacitracin A is oxidatively deaminated. PubChem:3082210 antibiotic_resistance ARO:3000631 bacitracin F ARO:3000631 Bacitracin F is a component of bacitracin, an antibiotic mixture that interferes with bacterial cell wall synthesis. It is formed when the thiazoline ring of bacitracin A is oxidatively deaminated. PMID:6752975 Benzylpenicillin, commonly referred to as penicillin G, is effective against both Gram-positive and Gram-negative bacteria. It is unstable in acid. CAS:61-33-6 ChEBI:18208 ChEMBL:CHEMBL29 PubChem:5904 Penicillin G benzopenicillin antibiotic_resistance ARO:3000632 benzylpenicillin ARO:3000632 Benzylpenicillin, commonly referred to as penicillin G, is effective against both Gram-positive and Gram-negative bacteria. It is unstable in acid. PMID:4610013 Phenoxymethylpenicillin, or penicillin V, is a penicillin derivative that is acid stable but less active than benzylpenicillin (penicillin G). CAS:87-08-1 ChEBI:27446 ChEMBL:CHEMBL615 PubChem:6869 penicillin V phenomycilline phenopenicillin antibiotic_resistance ARO:3000633 phenoxymethylpenicillin ARO:3000633 Phenoxymethylpenicillin, or penicillin V, is a penicillin derivative that is acid stable but less active than benzylpenicillin (penicillin G). PMID:3924086 Propicillin is an orally taken penicillin derivative that has high absorption but poor activity. CAS:551-27-9 ChEBI:52429 ChEMBL:CHEMBL2105612 PubChem:92879 levopropicillin antibiotic_resistance ARO:3000634 propicillin ARO:3000634 Propicillin is an orally taken penicillin derivative that has high absorption but poor activity. PMID:14056922 PMID:3588519 Dicloxacillin is a penicillin derivative that has an extra chlorine atom in comparison to cloxacillin. While more active than cloxacillin, its high affinity for serum protein reduces its activity in human serum in vitro. CAS:3116-76-5 ChEBI:4511 ChEMBL:CHEMBL893 PubChem:18381 dicloxacilin dicloxacycline antibiotic_resistance ARO:3000635 dicloxacillin ARO:3000635 Dicloxacillin is a penicillin derivative that has an extra chlorine atom in comparison to cloxacillin. While more active than cloxacillin, its high affinity for serum protein reduces its activity in human serum in vitro. PMID:3588519 PMID:3764352 Flucloxacillin is similar to cloxacillin, with an extra additional fluorine atom. CAS:5250-39-5 ChEBI:5098 PubChem:21319 floxacillin floxapen antibiotic_resistance ARO:3000636 flucloxacillin ARO:3000636 Flucloxacillin is similar to cloxacillin, with an extra additional fluorine atom. PMID:3588519 Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin. CAS:69-53-4 ChEBI:28971 ChEMBL:CHEMBL174 PubChem:6249 AMP Principen ampicillin acid antibiotic_resistance ARO:3000637 ampicillin ARO:3000637 Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin. PMID:3224398 PMID:44765 Azlocillin is a semisynthetic derivative of penicillin that is notably active against Ps. aeruginosa and other Gram-negative bacteria. CAS:37091-66-0 ChEBI:2956 ChEMBL:CHEMBL1537 PubChem:6479523 AZL antibiotic_resistance ARO:3000638 azlocillin ARO:3000638 Azlocillin is a semisynthetic derivative of penicillin that is notably active against Ps. aeruginosa and other Gram-negative bacteria. PMID:6369480 Mezlocillin is a penicillin derivative taken parenterally. CAS:51481-65-3 ChEBI:6919 ChEMBL:CHEMBL1731 PubChem:656511 mezlin antibiotic_resistance ARO:3000639 mezlocillin ARO:3000639 Mezlocillin is a penicillin derivative taken parenterally. PMID:6369480 Doripenem is a carbapenem with a broad range of activity against Gram-positive and Gram-negative bacteria, and along with meropenem, it is the most active beta-lactam antibiotic against Pseudomonas aeruginosa. It inhibits bacterial cell wall synthesis. CAS:148016-81-3 ChEBI:135928 ChEMBL:CHEMBL491571 PubChem:73303 DOR doribax antibiotic_resistance ARO:3000640 doripenem ARO:3000640 Doripenem is a carbapenem with a broad range of activity against Gram-positive and Gram-negative bacteria, and along with meropenem, it is the most active beta-lactam antibiotic against Pseudomonas aeruginosa. It inhibits bacterial cell wall synthesis. PMID:15047550 PMID:16307551 Cefalexin is a cephalosporin antibiotic that causes filamentation. It is resistant to staphylococcal beta-lactamase, but degraded by enterobacterial beta-lactamases. CAS:15686-71-2 ChEBI:3534 ChEMBL:CHEMBL1200544 PubChem:27447 LEX cephalexin antibiotic_resistance ARO:3000641 cefalexin ARO:3000641 Cefalexin is a cephalosporin antibiotic that causes filamentation. It is resistant to staphylococcal beta-lactamase, but degraded by enterobacterial beta-lactamases. PMID:4559812 Cefadroxil, or p-hydroxycephalexin, is an cephalosporin antibiotic similar to cefalexin. CAS:50370-12-2 ChEBI:3479 ChEMBL:CHEMBL1644 PubChem:47965 CFR p-hydroxycephalexin antibiotic_resistance ARO:3000642 cefadroxil ARO:3000642 Cefadroxil, or p-hydroxycephalexin, is an cephalosporin antibiotic similar to cefalexin. PMID:3542485 Cefotiam is a cephalosporin antibiotic with similar activity to cefuroxime but more active against enterobacteria. It is consumed orally as the prodrug cefotiam hexetil. CAS:61622-34-2 ChEBI:355510 ChEMBL:CHEMBL1296 PubChem:43708 cefotiamum antibiotic_resistance ARO:3000643 cefotiam ARO:3000643 Cefotiam is a cephalosporin antibiotic with similar activity to cefuroxime but more active against enterobacteria. It is consumed orally as the prodrug cefotiam hexetil. PMID:18611654 Cefaclor is a semisynthetic cephalosporin derived from cephalexin. It has broad-spectrum antibiotic activity. CAS:53994-73-3 ChEBI:3478 ChEMBL:CHEMBL1201018 PubChem:51039 CEC ceclor cephaclor antibiotic_resistance ARO:3000644 cefaclor ARO:3000644 Cefaclor is a semisynthetic cephalosporin derived from cephalexin. It has broad-spectrum antibiotic activity. PMID:10435677 Cefotaxime is a semisynthetic cephalosporin taken parenterally. It is resistant to most beta-lactamases and active against Gram-negative rods and cocci due to its aminothiazoyl and methoximino functional groups. CAS:63527-52-6 ChEBI:204928 ChEMBL:CHEMBL1730 PubChem:5742673 CTX cefotaxime acid antibiotic_resistance ARO:3000645 cefotaxime ARO:3000645 Cefotaxime is a semisynthetic cephalosporin taken parenterally. It is resistant to most beta-lactamases and active against Gram-negative rods and cocci due to its aminothiazoyl and methoximino functional groups. PMID:2083516 Cefixime is a cephalosporin resistant to most beta-lactamases. It is active against many enterobacteria, but activity against staphylococci is poor. CAS:79350-37-1 ChEBI:472657 ChEMBL:CHEMBL1541 PubChem:5362065 CFM necopen antibiotic_resistance ARO:3000646 cefixime ARO:3000646 Cefixime is a cephalosporin resistant to most beta-lactamases. It is active against many enterobacteria, but activity against staphylococci is poor. PMID:2684593 Cefpodoxime is a semisynthetic cephalosporin that acts similarly to cefotaxime with broad-spectrum activity. It is stable to many plasmid-mediated beta-lactamses. Cefpodoxime is consumed as the prodrug cefpodoxime proxetil. CAS:80210-62-4 ChEBI:3504 ChEMBL:CHEMBL1672 PubChem:6335986 CPD antibiotic_resistance ARO:3000647 cefpodoxime ARO:3000647 Cefpodoxime is a semisynthetic cephalosporin that acts similarly to cefotaxime with broad-spectrum activity. It is stable to many plasmid-mediated beta-lactamses. Cefpodoxime is consumed as the prodrug cefpodoxime proxetil. PMID:1280571 PMID:18611588 Ceftibuten is a semisynthetic cephalosporin active against Gram-negative bacilli. It is resistant against many plasmid-mediated beta-lactamases. CAS:97519-39-6 ChEBI:3510 ChEMBL:CHEMBL1605 PubChem:5282242 CTB Cedax antibiotic_resistance ARO:3000648 ceftibuten ARO:3000648 Ceftibuten is a semisynthetic cephalosporin active against Gram-negative bacilli. It is resistant against many plasmid-mediated beta-lactamases. PMID:7520858 PMID:9296244 Cefditoren is a semisynthetic cephalosporin active against staphylococci, streptococci, and and most enterobacteria. It is resistant to staphylococcal and most enterobacterial beta-lactamases, and is usually taken as the prodrug cefditoren pivoxil. CAS:104145-95-1 ChEBI:59343 ChEMBL:CHEMBL1743 PubChem:9571074 CDN antibiotic_resistance ARO:3000649 cefditoren ARO:3000649 Cefditoren is a semisynthetic cephalosporin active against staphylococci, streptococci, and and most enterobacteria. It is resistant to staphylococcal and most enterobacterial beta-lactamases, and is usually taken as the prodrug cefditoren pivoxil. PMID:7813385 Cefdinir is similar to cefixime with a modified side-chain at its 7-amino position. It also shares similar activity with cefixime but is more active against staphylococci. It has also be shown to enhance phagocytosis. CAS:192314-93-5 ChEBI:131724 ChEMBL:CHEMBL134561 PubChem:6915944 CDR antibiotic_resistance ARO:3000650 cefdinir ARO:3000650 Cefdinir is similar to cefixime with a modified side-chain at its 7-amino position. It also shares similar activity with cefixime but is more active against staphylococci. It has also be shown to enhance phagocytosis. PMID:8026155 Ceftaroline is a novel cephalosporin active against methicillin resistant Staphylococcus aureus. Like other cephalosporins it binds penicillin-binding proteins to inhibit cell wall synthesis. It strongly binds with PBP2a, associated with methicillin resistance. It is taken orally as the prodrug ceftaroline fosamil. CAS:189345-04-8 ChEBI:70729 ChEMBL:CHEMBL4594371 PubChem:9852982 CPT T91825 ceftaroline fosamil antibiotic_resistance ARO:3000651 ceftaroline ARO:3000651 Ceftaroline is a novel cephalosporin active against methicillin resistant Staphylococcus aureus. Like other cephalosporins it binds penicillin-binding proteins to inhibit cell wall synthesis. It strongly binds with PBP2a, associated with methicillin resistance. It is taken orally as the prodrug ceftaroline fosamil. PMID:18827379 PMID:21467022 PMID:27721280 A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae. ChEMBL:CHEMBL272080 PubChem:3037209 isepamicine isepamicinum antibiotic_resistance ARO:3000652 isepamicin ARO:3000652 A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae. PMID:8622111 A gentamicin class aminoglycoside antibiotic often used in mammalian cell culture work as a selectable marker for the neo cassette (APH3'). PubChem:123865 geneticin antibiotic_resistance ARO:3000653 G418 ARO:3000653 A gentamicin class aminoglycoside antibiotic often used in mammalian cell culture work as a selectable marker for the neo cassette (APH3'). PMID:4007271 PMID:6378088 A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci. CAS:51025-85-5 ChEBI:37922 ChEMBL:CHEMBL426926 PubChem:68682 habekacin haberacin antibiotic_resistance ARO:3000654 arbekacin ARO:3000654 A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci. PMID:10858356 PMID:7559197 Gentamicin B is a semisynthetic aminoglycoside antibacterial. PubChem:11754987 betamicin antibiotic_resistance ARO:3000655 gentamicin B ARO:3000655 Gentamicin B is a semisynthetic aminoglycoside antibacterial. PMID:9872733 AcrS is a repressor of the AcrAB efflux complex and is associated with the expression of AcrEF. AcrS is believed to regulate a switch between AcrAB and AcrEF efflux. AcrS ECK3251 JW3232 envR yhdK antibiotic_resistance ARO:3000656 AcrS ARO:3000656 AcrS is a repressor of the AcrAB efflux complex and is associated with the expression of AcrEF. AcrS is believed to regulate a switch between AcrAB and AcrEF efflux. PMID:18567659 AcrS An aminoglycoside antibiotic used for the treatment of parasitic infections. It is similar to neomycin sharing a similar spectrum of activity, but its hydroxyl group at the 6'-position instead of an amino group makes it resistant to AAC(6') modifying enzymes. CAS:7542-37-2 ChEBI:7934 ChEMBL:CHEMBL370143 PubChem:165580 Gabbomycin Humagel Humatin aminosidin aminosidine catenulin crestomycin estomycin hydroxymycin monomycin A neomycin E paucimycin antibiotic_resistance ARO:3000657 paromomycin ARO:3000657 An aminoglycoside antibiotic used for the treatment of parasitic infections. It is similar to neomycin sharing a similar spectrum of activity, but its hydroxyl group at the 6'-position instead of an amino group makes it resistant to AAC(6') modifying enzymes. PMID:11083628 PMID:8182014 Lividomycins are aminoglycosidic antibiotics produced by Streptomyces lividus. They contain 2-amino-2,3-dideoxy-D-glucose. ChEBI:71960 ChEMBL:CHEMBL389029 PubChem:72394 antibiotic_resistance ARO:3000658 lividomycin ARO:3000658 Lividomycins are aminoglycosidic antibiotics produced by Streptomyces lividus. They contain 2-amino-2,3-dideoxy-D-glucose. PMID:4586150 PMID:5091208 Gatifloxacin is an 8-methoxy, 7-piperazinyl, 6-fluoroquinolone that can be taken orally or by intravenous administration. It is active against most Gram-positive and Gram-negative bacteria, but inactive against non-fermenting Gram-negative rods including Pseudomonas aeruginosa. CAS:112811-59-3 ChEBI:5280 ChEMBL:CHEMBL31 PubChem:5379 AM-1155 Tequin antibiotic_resistance ARO:3000659 gatifloxacin ARO:3000659 Gatifloxacin is an 8-methoxy, 7-piperazinyl, 6-fluoroquinolone that can be taken orally or by intravenous administration. It is active against most Gram-positive and Gram-negative bacteria, but inactive against non-fermenting Gram-negative rods including Pseudomonas aeruginosa. PMID:8522459 Lomefloxacin is a difluoropiperazinyl quinolone, sharing similar activities with other fluoroquinolones. It is used to treat urinary tract infections. Relative to other fluoroquinolones, it has a longer half life and has higher serum concentrations. CAS:98079-51-7 ChEBI:116278 ChEMBL:CHEMBL561 PubChem:3948 antibiotic_resistance ARO:3000660 lomefloxacin ARO:3000660 Lomefloxacin is a difluoropiperazinyl quinolone, sharing similar activities with other fluoroquinolones. It is used to treat urinary tract infections. Relative to other fluoroquinolones, it has a longer half life and has higher serum concentrations. PMID:8394795 Nalidixic acid is a quinolone derivative of naphthyridine active against many enterobacteria, but ineffective against Ps aeruginosa, Gram-positive bacteria, and anaerobes. Acquired resistance is common in nalidixic acid treatments. CAS:389-08-2 ChEBI:100147 ChEMBL:CHEMBL5 PubChem:4421 nalidixin antibiotic_resistance ARO:3000661 nalidixic acid ARO:3000661 Nalidixic acid is a quinolone derivative of naphthyridine active against many enterobacteria, but ineffective against Ps aeruginosa, Gram-positive bacteria, and anaerobes. Acquired resistance is common in nalidixic acid treatments. PMID:18159374 Norfloxacin is a 6-fluoro, 7-piperazinyl quinolone with a wide range of activity against Gram-negative bacteria. It is inactive against most anaerobes. CAS:70458-96-7 ChEBI:100246 ChEMBL:CHEMBL9 PubChem:4539 antibiotic_resistance ARO:3000662 norfloxacin ARO:3000662 Norfloxacin is a 6-fluoro, 7-piperazinyl quinolone with a wide range of activity against Gram-negative bacteria. It is inactive against most anaerobes. PMID:3908074 Ofloxacin is a 6-fluoro, 7-piperazinyl quinolone with a methyl-substituted oxazine ring. It has a broad spectrum of activity including many enterobacteria and mycoplasma but most anaerobes are resistant. CAS:82419-36-1 ChEBI:7731 ChEMBL:CHEMBL4 PubChem:4583 Tarivid floxin antibiotic_resistance ARO:3000663 ofloxacin ARO:3000663 Ofloxacin is a 6-fluoro, 7-piperazinyl quinolone with a methyl-substituted oxazine ring. It has a broad spectrum of activity including many enterobacteria and mycoplasma but most anaerobes are resistant. PMID:1611900 PMID:18159374 PMID:3028966 Trovafloxacin is a trifluoroquinalone with a broad spectrum of activity that acts by inhibiting the uncoiling of supercoiled DNA. While potent against many Gram-positive and Gram-negative bacteria, it is less active against pseudomonads and Cl. difficile. It is usually taken as the prodrug trovafloxacin mesylate or alatrofloxacin mesylate for oral or intravenous administration, respectively. CAS:147059-72-1 ChEBI:9763 ChEMBL:CHEMBL428 PubChem:62959 Trovan alatrofloxacin antibiotic_resistance ARO:3000664 trovafloxacin ARO:3000664 Grepafloxacin is a broad-spectrum antibacterial quinoline. It is no longer taken due to its high toxicity. CAS:119914-60-2 ChEBI:5543 ChEMBL:CHEMBL583 PubChem:72474 Raxar antibiotic_resistance ARO:3000665 grepafloxacin ARO:3000665 Grepafloxacin is a broad-spectrum antibacterial quinoline. It is no longer taken due to its high toxicity. PMID:15992094 PMID:18159374 Sparfloxacin is a dimethylpiperazinyl difluoroquinolone that acts by inhibiting DNA gyrase. It is active against aerobic Gram-positive and Gram-negative bacteria, as well as some mycobacteria. It has moderate activity against some anaerobes. CAS:110871-86-8 ChEBI:9212 ChEMBL:CHEMBL850 PubChem:60464 Zagam antibiotic_resistance ARO:3000666 sparfloxacin ARO:3000666 Sparfloxacin is a dimethylpiperazinyl difluoroquinolone that acts by inhibiting DNA gyrase. It is active against aerobic Gram-positive and Gram-negative bacteria, as well as some mycobacteria. It has moderate activity against some anaerobes. PMID:1317145 Demeclocycline is a tetracycline analog with 7-chloro and 6-methyl groups. Due to its fast absorption and slow excretion, it maintains higher effective blood levels compared to other tetracyclines. CAS:127-33-3 ChEBI:4392 ChEMBL:CHEMBL1591 PubChem:54680690 DMCTC declomycin antibiotic_resistance ARO:3000667 demeclocycline ARO:3000667 Demeclocycline is a tetracycline analog with 7-chloro and 6-methyl groups. Due to its fast absorption and slow excretion, it maintains higher effective blood levels compared to other tetracyclines. PMID:194065 Oxytetracycline is a derivative of tetracycline with a 5-hydroxyl group. Its activity is similar to other tetracyclines. CAS:79-57-2 ChEBI:27701 ChEMBL:CHEMBL1517 PubChem:54675779 antibiotic_resistance ARO:3000668 oxytetracycline ARO:3000668 Oxytetracycline is a derivative of tetracycline with a 5-hydroxyl group. Its activity is similar to other tetracyclines. PMID:11381101 Virginiamycin M1 is a streptogramin A antibiotic. ChEMBL:CHEMBL1236670 PubChem:46936184 Pristinamycin IIA Pristinamycin IIB Virginiamycin IIB antibiotic_resistance ARO:3000669 virginiamycin M1 ARO:3000669 Virginiamycin M1 is a streptogramin A antibiotic. PMID:15700955 Pleuromutilins are natural fungal products that target bacterial protein translation by binding the the 23S rRNA, blocking the ribosome P site at the 50S subunit. They are mostly used for agriculture and veterinary purposes. antibiotic_resistance ARO:3000670 pleuromutilin antibiotic ARO:3000670 Pleuromutilins are natural fungal products that target bacterial protein translation by binding the the 23S rRNA, blocking the ribosome P site at the 50S subunit. They are mostly used for agriculture and veterinary purposes. PMID:11555289 PMID:15554968 PMID:16569865 PMID:17360517 PMID:20112168 PMID:931799 Tiamulin is a pleuromutilin derivative currently used in veterinary medicine. It binds to the 23 rRNA of the 50S ribosomal subunit to inhibit protein translation. CAS:55297-95-5 ChEBI:44137 ChEMBL:CHEMBL1234521 PubChem:656958 antibiotic_resistance ARO:3000671 tiamulin ARO:3000671 Tiamulin is a pleuromutilin derivative currently used in veterinary medicine. It binds to the 23 rRNA of the 50S ribosomal subunit to inhibit protein translation. PMID:11555289 PMID:15554968 PMID:19362093 PMID:20112168 Madumycin II is a streptogramin A antibiotic. PubChem:6441077 A2315A madumicin II antibiotic_resistance ARO:3000672 madumycin II ARO:3000672 Madumycin II is a streptogramin A antibiotic. PMID:15700955 Griseoviridin is a streptogramin A antibiotic. ChEBI:199588 PubChem:6441064 antibiotic_resistance ARO:3000673 griseoviridin ARO:3000673 Griseoviridin is a streptogramin A antibiotic. PMID:15700955 Dalfopristin is a water-soluble semi-synthetic derivative of pristinamycin IIA. It is produced by Streptomyces pristinaespiralis and is used in combination with quinupristin in a 7:3 ratio. Both work together to inhibit protein synthesis, and is active against Gram-positive bacteria. CAS:112362-50-2 ChEBI:4309 ChEMBL:CHEMBL1200937 PubChem:6323289 antibiotic_resistance ARO:3000674 dalfopristin ARO:3000674 Dalfopristin is a water-soluble semi-synthetic derivative of pristinamycin IIA. It is produced by Streptomyces pristinaespiralis and is used in combination with quinupristin in a 7:3 ratio. Both work together to inhibit protein synthesis, and is active against Gram-positive bacteria. PMID:15700955 Pristinamycin IB is a class B streptogramin similar to pristinamycin IA, the former containing a N-methyl-4-(methylamino)phenylalanine instead of a N-methyl-4-(dimethylamino)phenylalanine in its class A streptogramin counterpart (one less methyl group). ChEBI:8418 PubChem:443309 Virginiamycin S1 antibiotic_resistance ARO:3000675 pristinamycin IB ARO:3000675 Pristinamycin IB is a class B streptogramin similar to pristinamycin IA, the former containing a N-methyl-4-(methylamino)phenylalanine instead of a N-methyl-4-(dimethylamino)phenylalanine in its class A streptogramin counterpart (one less methyl group). PMID:15700955 H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE, mdtE, and emrK as well as nearby genes of many RND-type multidrug exporters. H-NS hns antibiotic_resistance ARO:3000676 H-NS ARO:3000676 H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE, mdtE, and emrK as well as nearby genes of many RND-type multidrug exporters. PMID:14973023 H-NS Virginiamycin S2 is a streptogramin B antibiotic. PubChem:101826968 antibiotic_resistance ARO:3000677 virginiamycin S2 ARO:3000677 Virginiamycin S2 is a streptogramin B antibiotic. PMID:15700955 Pristinamycin IC is a class B streptogramin derived from virginiamycin S1. PubChem:443310 Vernamycin B gamma Virginiamycin S1 antibiotic_resistance ARO:3000678 pristinamycin IC ARO:3000678 Pristinamycin IC is a class B streptogramin derived from virginiamycin S1. PMID:15700955 Vernamycin C is a streptogramin B antibiotic. PubChem:90478435 antibiotic_resistance ARO:3000679 vernamycin C ARO:3000679 Vernamycin C is a streptogramin B antibiotic. PMID:15700955 Patricin A is a streptogramin B antibiotic. PubChem:13041217 antibiotic_resistance ARO:3000680 patricin A ARO:3000680 Patricin A is a streptogramin B antibiotic. PMID:15700955 Patricin B is a streptogramin B antibiotic. PubChem:13041217 antibiotic_resistance ARO:3000681 patricin B ARO:3000681 Patricin B is a streptogramin B antibiotic. PMID:15700955 Ostreogrycin B3 is a derivative of pristinamycin IA, with an additional 3-hydroxy group on its 4-oxopipecolic acid. PubChem:71751769 antibiotic_resistance ARO:3000682 ostreogrycin B3 ARO:3000682 Ostreogrycin B3 is a derivative of pristinamycin IA, with an additional 3-hydroxy group on its 4-oxopipecolic acid. PMID:15700955 Sulfacetamide is a very soluable sulfonamide antibiotic previously used to treat urinary tract infections. Its relatively low activity and toxicity to those with Stevens-Johnson syndrome have reduced its use and availability. CAS:144-80-9 ChEBI:63845 ChEMBL:CHEMBL455 PubChem:5320 antibiotic_resistance ARO:3000683 sulfacetamide ARO:3000683 Sulfacetamide is a very soluable sulfonamide antibiotic previously used to treat urinary tract infections. Its relatively low activity and toxicity to those with Stevens-Johnson syndrome have reduced its use and availability. PMID:8133250 Mafenide is a sulfonamide used topically for treating burns. CAS:138-39-6 ChEBI:6633 ChEMBL:CHEMBL419 PubChem:3998 ambamide maphenide sulfamylon antibiotic_resistance ARO:3000684 mafenide ARO:3000684 Mafenide is a sulfonamide used topically for treating burns. PMID:4948236 Arylomycins are lipopeptide antibiotics, sharing a lipohexapeptide with a C-terminal tripeptide macrolide and varying by the length of its alkyl chains. PubChem:54586211 antibiotic_resistance ARO:3000685 arylomycin ARO:3000685 Arylomycins are lipopeptide antibiotics, sharing a lipohexapeptide with a C-terminal tripeptide macrolide and varying by the length of its alkyl chains. PMID:21545107 Thiostrepton is a cyclic peptide active against Gram-positive bacteria. It is produced by streptomyces bacteria. CAS:1393-48-2 ChEBI:29693 ChEMBL:CHEMBL1236460 PubChem:16129666 bryamycin thiactin antibiotic_resistance ARO:3000686 thiostrepton ARO:3000686 Thiostrepton is a cyclic peptide active against Gram-positive bacteria. It is produced by streptomyces bacteria. PMID:5409975 Moemomycin antibiotics are phosphoglycolipids that contain a 3-phosphoglyceric acid, often used as a mixture. They inhibit petidoglycan glycosyltransferases to prevent bacterial cell wall biosynthesis. Flavomycin Flavophospholipol bambermycin antibiotic_resistance ARO:3000687 moenomycin antibiotic ARO:3000687 Moemomycin antibiotics are phosphoglycolipids that contain a 3-phosphoglyceric acid, often used as a mixture. They inhibit petidoglycan glycosyltransferases to prevent bacterial cell wall biosynthesis. PMID:17117848 PMID:20730219 Furazolidone is a nitrofuran antibiotic that is a non-ionic synthetic compound. It is taken orally and is active against many enteric pathogens. Furazolidone also has antiprotozoal activity and acts by inhibiting monoamine oxidase. CAS:67-45-8 ChEBI:5195 ChEMBL:CHEMBL1103 PubChem:5323714 furazolidine furoxone nitrofurazolidone antibiotic_resistance ARO:3000688 furazolidone ARO:3000688 Furazolidone is a nitrofuran antibiotic that is a non-ionic synthetic compound. It is taken orally and is active against many enteric pathogens. Furazolidone also has antiprotozoal activity and acts by inhibiting monoamine oxidase. PMID:3514312 Metronidazole is a nitroimidazole that is active against anaerobic bacteria and protozoa. It is not effective against aerobic bacteria. Nitroimidazoles act by oxidizing DNA causing strand breaks and cell death. CAS:443-48-1 ChEBI:6909 ChEMBL:CHEMBL137 PubChem:4173 Flagyl metronidazol antibiotic_resistance ARO:3000689 metronidazole ARO:3000689 Metronidazole is a nitroimidazole that is active against anaerobic bacteria and protozoa. It is not effective against aerobic bacteria. Nitroimidazoles act by oxidizing DNA causing strand breaks and cell death. PMID:8444678 Bleomycinic acid is a glycopeptide antibiotic produced by Streptomyces verticillus taken as a mixture of bleomycins. It induces stand breaks in bacterial nucleic acids. PubChem:2410 antibiotic_resistance ARO:3000690 bleomycinic acid ARO:3000690 Bleomycinic acid is a glycopeptide antibiotic produced by Streptomyces verticillus taken as a mixture of bleomycins. It induces stand breaks in bacterial nucleic acids. PMID:15700963 Bleomycin A2 is a glycopeptide antibiotic produced by Streptomyces verticillus taken as a mixture of bleomycins. It induces stand breaks in bacterial nucleic acids. CAS:11056-06-7 ChEBI:3139 PubChem:5460769 antibiotic_resistance ARO:3000691 bleomycin A2 ARO:3000691 Bleomycin A2 is a glycopeptide antibiotic produced by Streptomyces verticillus taken as a mixture of bleomycins. It induces stand breaks in bacterial nucleic acids. PMID:15700963 Bleomycin B2 is a glycopeptide antibiotic produced by Streptomyces verticillus taken as a mixture of bleomycins. It induces stand breaks in bacterial nucleic acids. PubChem:5496540 antibiotic_resistance ARO:3000692 bleomycin B2 ARO:3000692 Bleomycin B2 is a glycopeptide antibiotic produced by Streptomyces verticillus taken as a mixture of bleomycins. It induces stand breaks in bacterial nucleic acids. PMID:15700963 Defensins are natural cationic peptides that have antibiotic properties. It is part of the innate immune system of plants and animals. ChEBI:82761 PubChem:56841867 antibiotic_resistance ARO:3000693 defensin ARO:3000693 Defensins are natural cationic peptides that have antibiotic properties. It is part of the innate immune system of plants and animals. PMID:12949495 Magainins are antimicrobial peptides produced by amphibians skil cells as part of their innate immune system. It is active against a broad range of gram-negative and gram-positive bacteria, fungi and protozoa. megainin antibiotic_resistance ARO:3000694 magainin ARO:3000694 Magainins are antimicrobial peptides produced by amphibians skil cells as part of their innate immune system. It is active against a broad range of gram-negative and gram-positive bacteria, fungi and protozoa. PMID:3277183 Actinomycins are peptide antibiotics that interact with DNA. This prevents RNA synthesis, thus preventing the production of proteins vital to the cell. antibiotic_resistance ARO:3000695 actinomycin ARO:3000695 Actinomycins are peptide antibiotics that interact with DNA. This prevents RNA synthesis, thus preventing the production of proteins vital to the cell. PMID:2410919 Dactinomycin, also known as Actinomycin D, is a cyclic peptide antibiotic that interacts with DNA to inhibit RNA synthesis. ChEBI:27666 ChEMBL:CHEMBL1554 PubChem:457193 Actinomycin D antibiotic_resistance ARO:3000696 Dactinomycin ARO:3000696 Dactinomycin, also known as Actinomycin D, is a cyclic peptide antibiotic that interacts with DNA to inhibit RNA synthesis. PMID:2410919 Moenomycin A1 is a major component of moenomycin mixtures. It is produced by Streptomyces ghanaensis, S. bambergiensis, S. ederensis, and S. geysiriensis. ChEMBL:CHEMBL2367578 PubChem:15235578 antibiotic_resistance ARO:3000697 moenomycin A1 ARO:3000697 Moenomycin A1 is a major component of moenomycin mixtures. It is produced by Streptomyces ghanaensis, S. bambergiensis, S. ederensis, and S. geysiriensis. PMID:17117848 Sulfasalazine is a derivative of the early sulfonamide sulfapyridine (salicylazosulfapyridine). It was developed to increase water solubility and is taken orally for ulcerative colitis. CAS:599-79-1 ChEBI:9334 ChEMBL:CHEMBL421 PubChem:5339 salicylazosulfapyridine antibiotic_resistance ARO:3000698 sulfasalazine ARO:3000698 Sulfasalazine is a derivative of the early sulfonamide sulfapyridine (salicylazosulfapyridine). It was developed to increase water solubility and is taken orally for ulcerative colitis. PMID:22555 Sulfamethizole is a short-acting sulfonamide that inhibits dihydropteroate synthetase. CAS:144-82-1 ChEBI:9331 ChEMBL:CHEMBL1191 PubChem:5328 Urolucosil sulfamethizol sulphamethizole antibiotic_resistance ARO:3000699 sulfamethizole ARO:3000699 Sulfamethizole is a short-acting sulfonamide that inhibits dihydropteroate synthetase. PMID:2372557 Lividomycin A is a pentasaccharide antibiotic which interferes with bacterial protein synthesis. CAS:36441-41-5 ChEBI:71961 ChEMBL:CHEMBL389029 PubChem:72394 antibiotic_resistance ARO:3000700 lividomycin A ARO:3000700 Lividomycin A is a pentasaccharide antibiotic which interferes with bacterial protein synthesis. PMID:4586150 PMID:5092786 Lividomycin B is a derivative of lividomycin A with a removed mannose group (demannosyllividomycin A). Livodomycins interfere with bacterial protein synthesis. CAS:37636-51-4 ChEBI:71962 PubChem:46174031 antibiotic_resistance ARO:3000701 lividomycin B ARO:3000701 Lividomycin B is a derivative of lividomycin A with a removed mannose group (demannosyllividomycin A). Livodomycins interfere with bacterial protein synthesis. PMID:4586150 PMID:5034809 AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance. antibiotic_resistance ARO:3000702 acrR ARO:3000702 AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance. PMID:12121946 Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. CAS:153-61-7 ChEBI:124991 ChEMBL:CHEMBL617 PubChem:6024 CEF cephalothin antibiotic_resistance ARO:3000704 cefalotin ARO:3000704 Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases. PMID:14251901 PMID:7571387 Mixtures of antibiotics are commonly used clinically. These mixtures link to antibiotic molecules that are also listed in their respective families under antibiotic molecules. i.e. 'Gramicidin A' is part of the mixture 'gramicidin D', while 'Gramicidin A' is also a 'gramicidin', which is a 'peptide antibiotic'. antibiotic_resistance ARO:3000707 antibiotic mixture ARO:3000707 Antibiotic targets are components of the bacterial or fungal cell. Bacterial targets are usually significantly different from their eukaryotic counterparts to allow for selective antibacterial activity. Exceptions include antibiotics that are converted to an active form inside the bacterium. Resistance mechanisms may modify these targets to protect bacteria or fungi from the effects of antibiotics. antibiotic_resistance ARO:3000708 antibiotic target ARO:3000708 Cell wall biosynthesis provides bacteria with a layer of peptidoglycan that provides rigidity and protects the cell from lysis due to osmotic pressure. Cell wall structures vary significantly between Gram-positive and Gram-negative bacteria, while mycobacteria have a unique cell wall composition. antibiotic_resistance ARO:3000709 cell wall synthesis enzyme targeted by antibiotic ARO:3000709 Cell wall biosynthesis provides bacteria with a layer of peptidoglycan that provides rigidity and protects the cell from lysis due to osmotic pressure. Cell wall structures vary significantly between Gram-positive and Gram-negative bacteria, while mycobacteria have a unique cell wall composition. PMID:1436736 Interaction with the cell membrane phospholipids interferes with membrane permeability and integrity, leading to the leakage of cell contents. The outer membrane of Gram-negative bacteria is particularly sensitive. antibiotic_resistance ARO:3000710 cell membrane component targeted by antibiotic ARO:3000710 Interaction with the cell membrane phospholipids interferes with membrane permeability and integrity, leading to the leakage of cell contents. The outer membrane of Gram-negative bacteria is particularly sensitive. PMID:17572379 PMID:20818945 PMID:4334683 PMID:8528769 Protein synthesis in bacteria is accomplished by cytosolic ribosomes that are structurally different from eukaryotic ribosomes, and thus a target for many antibiotics. By inhibiting ribosomal activity, either by directly binding to the ribosome or interacting with co-factors, antibiotics prevent protein synthesis. antibiotic_resistance ARO:3000711 protein synthesis machinery targeted by antibiotic ARO:3000711 Bacterial DNA and RNA synthesis includes many enzymes unique to bacteria that are targeted by antibiotics. antibiotic_resistance ARO:3000712 nucleic acid synthesis machinery targeted by antibiotic ARO:3000712 Bacterial DNA and RNA synthesis includes many enzymes unique to bacteria that are targeted by antibiotics. PMID:22458504 Nucleic acids can also be targeted by antibiotics. These drugs are usually converted to an active form by enzymes unique to bacteria to prevent toxicity to the host. antibiotic_resistance ARO:3000713 nucleic acid targeted by antibiotic ARO:3000713 Nucleic acids can also be targeted by antibiotics. These drugs are usually converted to an active form by enzymes unique to bacteria to prevent toxicity to the host. PMID:15685195 Enzymes in the folate synthesis pathway are targeted by two main classes of antibiotics: sulfonamides and diaminopyrimidines. Inhibition of these enzymes block the production of key precursors for nucleotides and amino acids. antibiotic_resistance ARO:3000714 folate synthesis enzyme targeted by antibiotic ARO:3000714 Enzymes in the folate synthesis pathway are targeted by two main classes of antibiotics: sulfonamides and diaminopyrimidines. Inhibition of these enzymes block the production of key precursors for nucleotides and amino acids. PMID:4387360 Enzymes in this pathway generate important precursors for macromolecules. While eukaryotes and prokaryotes both synthesize isoprenoids, many bacteria and notably mycobacteria use an alternative pathway that is targeted by antibiotics. antibiotic_resistance ARO:3000715 isoprenoid synthesis enzyme targeted by antibiotic ARO:3000715 Enzymes in this pathway generate important precursors for macromolecules. While eukaryotes and prokaryotes both synthesize isoprenoids, many bacteria and notably mycobacteria use an alternative pathway that is targeted by antibiotics. PMID:16321944 PMID:17430177 Mycolic acids are produced by mycobacteria. These fatty acids are required for the construction of cell walls. Enzymes that are targeted by antibiotics include synthases, elongases, and dehydrogenases. antibiotic_resistance ARO:3000716 mycolic acid synthesis enzyme targeted by antibiotic ARO:3000716 Mycolic acids are produced by mycobacteria. These fatty acids are required for the construction of cell walls. Enzymes that are targeted by antibiotics include synthases, elongases, and dehydrogenases. PMID:1656850 PMID:8143118 Signal peptidase I is a bacterial signal peptidase that cleaves signal peptides from translated proteins. These signal peptides direct proteins to their destination, and then must be cleaved in order to function. antibiotic_resistance ARO:3000717 antibiotic sensitive signal peptidase I ARO:3000717 Signal peptidase I is a bacterial signal peptidase that cleaves signal peptides from translated proteins. These signal peptides direct proteins to their destination, and then must be cleaved in order to function. PMID:15173160 PMID:21189343 PMID:7023361 MarR is a repressor of the mar operon marRAB, thus regulating the expression of marA, the activator of multidrug efflux pump AcrAB. antibiotic_resistance ARO:3000718 marR ARO:3000718 MarR is a repressor of the mar operon marRAB, thus regulating the expression of marA, the activator of multidrug efflux pump AcrAB. PMID:12027588 PMID:9333027 Isoprepnyl pyrophosphate removes a phosphate group that is added from the peptidoglycan subunit to permit its transfer across the cell membrane. The phosphate group must be removed before its incorporation into peptidoglycan macromolecules. antibiotic_resistance ARO:3000719 bacitracin sensitive isoprenyl pyrophosphate ARO:3000719 Isoprepnyl pyrophosphate removes a phosphate group that is added from the peptidoglycan subunit to permit its transfer across the cell membrane. The phosphate group must be removed before its incorporation into peptidoglycan macromolecules. PMID:18258256 PMID:4332017 PMID:4350651 PMID:6752975 The acyl-D-alanyl-D-alanine group is found at the terminal end of the pentapeptide chains of peptidoglycan subunits. Antibiotics that bind to this group block the addition of subunits, inhibiting peptidoglycan synthesis. This group is most accessible in Gram-postive bacteria. antibiotic_resistance ARO:3000720 acyl-D-alanyl-D-alanine ARO:3000720 The acyl-D-alanyl-D-alanine group is found at the terminal end of the pentapeptide chains of peptidoglycan subunits. Antibiotics that bind to this group block the addition of subunits, inhibiting peptidoglycan synthesis. This group is most accessible in Gram-postive bacteria. PMID:18258256 The cell wall is unique to bacteria and provides rigidity and protects the cell from lysis due to osmotic pressure. Its characteristic component is peptidoglycan, though cell wall structures vary significantly between Gram-positive and Gram-negative bacteria, as well as mycobacteria. antibiotic_resistance ARO:3000721 cell wall component targeted by antibiotic ARO:3000721 The cell wall is unique to bacteria and provides rigidity and protects the cell from lysis due to osmotic pressure. Its characteristic component is peptidoglycan, though cell wall structures vary significantly between Gram-positive and Gram-negative bacteria, as well as mycobacteria. PMID:4568761 Alanine racemase (alr) converts the natural L-alanine to the D-alanine required in the pentapeptide chains in peptidoglycan. It is found in both Gram-positive and Gram-negative bacteria. antibiotic_resistance ARO:3000722 cycloserine sensitive alr ARO:3000722 Alanine racemase (alr) converts the natural L-alanine to the D-alanine required in the pentapeptide chains in peptidoglycan. It is found in both Gram-positive and Gram-negative bacteria. PMID:19748470 PMID:4555420 D-Alanine synthetase (or ligase), also known as ddla, joins two D-alanines before their addition to the pentapeptide chains of peptidoglycan. It is found in both Gram-positive and Gram-negative bacteria. antibiotic_resistance ARO:3000723 cycloserine sensitive D-alanine synthetase ARO:3000723 D-Alanine synthetase (or ligase), also known as ddla, joins two D-alanines before their addition to the pentapeptide chains of peptidoglycan. It is found in both Gram-positive and Gram-negative bacteria. PMID:14479178 Pyruvyl transferase is responsible for the conversion of N-acetylglucosamine (NAG) to N-acetylmuramic acid (NAMA). NAMA is a part of the macromolecular backbone of peptidoglycans. Pyruvyl transferase is found in both Gram-positive and Gram-negative bacteria. antibiotic_resistance ARO:3000724 fosfomycin sensitive pyruvyl transferase (murA) ARO:3000724 Pyruvyl transferase is responsible for the conversion of N-acetylglucosamine (NAG) to N-acetylmuramic acid (NAMA). NAMA is a part of the macromolecular backbone of peptidoglycans. Pyruvyl transferase is found in both Gram-positive and Gram-negative bacteria. PMID:4605290 Arabinofuranosyltransferases allow for the polymerization of arabinose to form arabinan. Arabanan is required for formation of mycobacterial cell walls. antibiotic_resistance ARO:3000725 antibiotic sensitive aftA ARO:3000725 Arabinofuranosyltransferases allow for the polymerization of arabinose to form arabinan. Arabanan is required for formation of mycobacterial cell walls. PMID:18174142 PMID:19596878 The pentaglycyl bridge is part of Gram-positive peptidoglycan, allowing the formation of a thick and rigid cell wall. antibiotic_resistance ARO:3000726 pentaglycyl bridge ARO:3000726 The pentaglycyl bridge is part of Gram-positive peptidoglycan, allowing the formation of a thick and rigid cell wall. PMID:18258256 The larger of two ribosomal subunits that make up the 70S bacterial ribosome. antibiotic_resistance ARO:3000727 50S ribosomal subunit ARO:3000727 The larger of two ribosomal subunits that make up the 70S bacterial ribosome. PMID:10445875 PMID:16257828 The smaller of two ribosomal subunits that make up the 70S bacterial ribosome. antibiotic_resistance ARO:3000728 30S ribosomal subunit ARO:3000728 The smaller of two ribosomal subunits that make up the 70S bacterial ribosome. PMID:15755955 The ribosomal complex can be targeted by antibiotics that stabilize the entire complex and prevent further translation. These antibiotics target both subunits in the process of protein translation. antibiotic_resistance ARO:3000729 ribosomal complex ARO:3000729 The ribosomal complex can be targeted by antibiotics that stabilize the entire complex and prevent further translation. These antibiotics target both subunits in the process of protein translation. PMID:17515906 PMID:202460 Elongation factor G (EF-G) provides energy for the translocation step in protein synthesis. Antibiotics that target EF-G allow one round of translocation but prevent EF-G from dissociating from the ribosome-RNA complex. antibiotic_resistance ARO:3000730 elongation factor G ARO:3000730 Elongation factor G (EF-G) provides energy for the translocation step in protein synthesis. Antibiotics that target EF-G allow one round of translocation but prevent EF-G from dissociating from the ribosome-RNA complex. PMID:17980694 PMID:9678602 Elongation factor Tu is required for peptide elongation in bacterial protein synthesis. EF-Tu antibiotic_resistance ARO:3000731 elongation factor Tu ARO:3000731 Elongation factor Tu is required for peptide elongation in bacterial protein synthesis. PMID:364475 PMID:9678602 Isoleucyl-tRNA transferase recognizes isoleucine codons and works with the ribosome to incorporate isoleucine amino acids into polypeptide chains. It can be targeted by antibiotics that have an analog of isoleucine through competitive inhibition. ileS antibiotic_resistance ARO:3000732 antibiotic sensitive Isoleucyl-tRNA transferase ARO:3000732 Isoleucyl-tRNA transferase recognizes isoleucine codons and works with the ribosome to incorporate isoleucine amino acids into polypeptide chains. It can be targeted by antibiotics that have an analog of isoleucine through competitive inhibition. PMID:5803296 PMID:7929087 DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Binding the alpha-subunit is sufficient to inhibit DNA supercoiling. gyrase A antibiotic_resistance ARO:3000733 fluoroquinolone sensitive gyrA ARO:3000733 DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Binding the alpha-subunit is sufficient to inhibit DNA supercoiling. PMID:1657531 PMID:9293187 DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Binding the beta-subunit is sufficient to inhibit DNA supercoiling. gyrase B gyrase beta subunit gyrase subunit B antibiotic_resistance ARO:3000734 antibiotic sensitive DNA topoisomerase subunit gyrB ARO:3000734 DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Binding the beta-subunit is sufficient to inhibit DNA supercoiling. PMID:1657531 PMID:9293187 parC is a subunit of the DNA topoisomerase IV and is sensitive to fluoroquinolone. antibiotic_resistance ARO:3000735 Fluoroquinolone sensitive parC ARO:3000735 parC is a subunit of the DNA topoisomerase IV and is sensitive to fluoroquinolone. PMID:9293187 The rho transcription terminator factor moves along RNA as it is transcribed, unwinding the RNA from the DNA. It is also responsible for recognizing transcription termination pause sites, slowing down RNA polymerase and allowing mRNA to be released. antibiotic_resistance ARO:3000736 rho transcription terminator factor ARO:3000736 The rho transcription terminator factor moves along RNA as it is transcribed, unwinding the RNA from the DNA. It is also responsible for recognizing transcription termination pause sites, slowing down RNA polymerase and allowing mRNA to be released. PMID:21326894 PMID:8466900 The beta-subunit of RNA polymerase is targeted as a complex. When blocked, RNA strand elongation cannot continue after the first few nucleotides. antibiotic_resistance ARO:3000737 rifamycin sensitive beta-subunit of RNA polymerase (rpoB) ARO:3000737 The beta-subunit of RNA polymerase is targeted as a complex. When blocked, RNA strand elongation cannot continue after the first few nucleotides. PMID:15700959 Antibiotics can target DNA to cause strand breaks or prevent transcription. The activity of these antibiotics can be context dependent: some antibiotics are converted to an active form only in certain species, while others target DNA as it is being transcribed. DNA antibiotic_resistance ARO:3000738 deoxyribonucleic acid ARO:3000738 Antibiotics can target DNA to cause strand breaks or prevent transcription. The activity of these antibiotics can be context dependent: some antibiotics are converted to an active form only in certain species, while others target DNA as it is being transcribed. PMID:15685195 PMID:4941089 PMID:63969 RNA intron self-splicing action can be inhibited by antibiotics that target a G-binding site to compete with the guanosine cofactor. antibiotic_resistance ARO:3000739 RNA guanosine binding site ARO:3000739 RNA intron self-splicing action can be inhibited by antibiotics that target a G-binding site to compete with the guanosine cofactor. PMID:7509881 Many types of ribonucleic acids (RNAs) are targeted by antibiotics, including mRNA templates and ribosomal RNA. Some antibiotics target all RNAs and cause strand breaks. RNA antibiotic_resistance ARO:3000740 ribonucleic acid ARO:3000740 Many types of ribonucleic acids (RNAs) are targeted by antibiotics, including mRNA templates and ribosomal RNA. Some antibiotics target all RNAs and cause strand breaks. PMID:15685195 PMID:1701259 PMID:63969 PMID:7509881 DNA in the transcriptional complex is partially unwound, allowing antibiotics to target exposed bases and prevent DNA transcription. antibiotic_resistance ARO:3000741 transcription complex DNA ARO:3000741 DNA in the transcriptional complex is partially unwound, allowing antibiotics to target exposed bases and prevent DNA transcription. PMID:13948669 PMID:2410919 DNA in anaerobes are targeted by antibiotics that are converted to an active form in the anaerobe environment. For nitroimidazoles, the antibiotic is reduced to a highly oxidative intermediate that causes DNA oxidation and double-stranded breaks. antibiotic_resistance ARO:3000742 anaerobe DNA ARO:3000742 DNA in anaerobes are targeted by antibiotics that are converted to an active form in the anaerobe environment. For nitroimidazoles, the antibiotic is reduced to a highly oxidative intermediate that causes DNA oxidation and double-stranded breaks. PMID:8444678 This reductoisomerase is found in an alternate isoprenoid synthase pathway that is mevalonate independent. Isoprenoids are important precursors to many other macromolecules. This non-mevalonate pathway is used by plants and most bacteria, including mycobacteria, but not eukaryotes, allowing for selectivea action. Staphylococcus aureus and some other Gram-positive bacteria use a mevalonate-dependent pathway, and are resistant against 1-deoxy-D-xylose 5-phosphate reductoisomerase inhibitors. antibiotic_resistance ARO:3000743 1-deoxy-D-xylulose 5-phosphate reductoisomerase ARO:3000743 This reductoisomerase is found in an alternate isoprenoid synthase pathway that is mevalonate independent. Isoprenoids are important precursors to many other macromolecules. This non-mevalonate pathway is used by plants and most bacteria, including mycobacteria, but not eukaryotes, allowing for selectivea action. Staphylococcus aureus and some other Gram-positive bacteria use a mevalonate-dependent pathway, and are resistant against 1-deoxy-D-xylose 5-phosphate reductoisomerase inhibitors. PMID:16321944 PMID:17430177 Dihydropteroate synthase catalyzes the conversion of p-aminobenzoic acid to dihydropteroic acid as part of the tetrahydrofolic acid biosynthetic pathway. Tetrahydrofolic acid is essential for folate synthesis, and a precursor of many nucleotides and amino acids. Inhibiting dihydropteroate leads to slow cell death, as bacteria can survive on existing folate storages for a few generations. antibiotic_resistance ARO:3000744 antibiotic sensitive dihydropteroate synthase ARO:3000744 Dihydropteroate synthase catalyzes the conversion of p-aminobenzoic acid to dihydropteroic acid as part of the tetrahydrofolic acid biosynthetic pathway. Tetrahydrofolic acid is essential for folate synthesis, and a precursor of many nucleotides and amino acids. Inhibiting dihydropteroate leads to slow cell death, as bacteria can survive on existing folate storages for a few generations. PMID:12111724 Dihydrofolate reductase synthesizes the co-enzyme tetrahydrofolic acid, which is also an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. FolA antibiotic_resistance ARO:3000745 antibiotic sensitive dihydrofolate reductase ARO:3000745 Dihydrofolate reductase synthesizes the co-enzyme tetrahydrofolic acid, which is also an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. PMID:12781525 MepR is an upstream repressor of MepA in Staphylococcus aureus. It is part of the mepRAB operon. mepR antibiotic_resistance ARO:3000746 mepR ARO:3000746 MepR is an upstream repressor of MepA in Staphylococcus aureus. It is part of the mepRAB operon. PMID:15855507 PMID:15855508 PMID:16569840 mepR Mef efflux pumps are MFS-type transporters that confer macrolide resistance in Streptococcus pneumoniae. antibiotic_resistance ARO:3000747 mef ARO:3000747 Mef efflux pumps are MFS-type transporters that confer macrolide resistance in Streptococcus pneumoniae. PMID:16189099 Subunits of efflux proteins that pump antibiotic out of a cell to confer resistance. antibiotic_resistance ARO:3000748 subunit of efflux pump conferring antibiotic resistance ARO:3000748 Penicillin-binding proteins (PBPs) are responsible for transpeptidation, joining subunits to form peptidoglycan. They are numbered according to descending molecular weight, and may vary between species. These numbers represent the PBPs of E. coli. Inhibition of the larger PBPs responsible for transpeptidation (1-3) are lethal. Smaller PBPs (4-6) are involed in carboxypeptidation; inhibition of these is non-lethal. antibiotic_resistance ARO:3000749 beta-lactam sensitive penicillin-binding protein ARO:3000749 Penicillin-binding proteins (PBPs) are responsible for transpeptidation, joining subunits to form peptidoglycan. They are numbered according to descending molecular weight, and may vary between species. These numbers represent the PBPs of E. coli. Inhibition of the larger PBPs responsible for transpeptidation (1-3) are lethal. Smaller PBPs (4-6) are involed in carboxypeptidation; inhibition of these is non-lethal. PMID:3055170 A protein, either a histidine kinase or a response regulator, that is part of a two-component regulatory system that directly or indirectly change rates of antibiotic efflux. antibiotic_resistance ARO:3000750 protein of two-component regulatory system modulating antibiotic efflux ARO:3000750 AbeM is an multidrug efflux pump found in Acinetobacter baumannii. abeM antibiotic_resistance ARO:3000753 abeM ARO:3000753 AbeM is an multidrug efflux pump found in Acinetobacter baumannii. PMID:16189122 abeM The bacterial 23S rRNA, at the P site of the 50S subunit, has peptidyl transferase activity and is responsible for peptide synthesis and elongation. antibiotic_resistance ARO:3000754 antibiotic sensitive peptidyl transferase (23S rRNA) ARO:3000754 The bacterial 23S rRNA, at the P site of the 50S subunit, has peptidyl transferase activity and is responsible for peptide synthesis and elongation. PMID:10445875 PMID:16257828 PMID:16569865 The 16S rRNA of the 30S ribosomal subunit helps to stabilize the aminoacyl-tRNAs for pairing with the mRNA codons. Some antibiotics (aminoglycosides) that target the 16S rRNA lead to mRNA misreading as well as premature termination. Other antibiotics (tetracyclines) that target the 16S rRNA prevent incoming charged-tRNAs from binding to the ribosome's A-site, stopping elongation. antibiotic_resistance ARO:3000755 antibiotic sensitive 16S rRNA ARO:3000755 The 16S rRNA of the 30S ribosomal subunit helps to stabilize the aminoacyl-tRNAs for pairing with the mRNA codons. Some antibiotics (aminoglycosides) that target the 16S rRNA lead to mRNA misreading as well as premature termination. Other antibiotics (tetracyclines) that target the 16S rRNA prevent incoming charged-tRNAs from binding to the ribosome's A-site, stopping elongation. PMID:9662506 The P-site of the ribosome binds the peptidyl-tRNA with the growing polypeptide chain. Antibiotics that target the P-site block fMet-tRNA from entering, thus inhibiting peptide elongation. antibiotic_resistance ARO:3000756 30S ribosomal subunit P-site ARO:3000756 The P-site of the ribosome binds the peptidyl-tRNA with the growing polypeptide chain. Antibiotics that target the P-site block fMet-tRNA from entering, thus inhibiting peptide elongation. PMID:15755955 The P-site of the ribosome binds the peptidyl-tRNA with the growing polypeptide chain, and is a common target for many antibiotics that inhibit the 50S ribosomal subunit. Some antibiotics (oxazolidinones) block the 50S subunit from interacting with the 30S subunit to prevent the formation of the ribosomal complex. Other antibiotics (thiostrepton) block the 50S subunit from interacting with elongation factors G and Tu (EF-G, Ef-Tu), preventing GTP-dependent reactions of peptidyl transferase, and translocation, respectively. Other antibiotics (macrolides) prevent protein translocation. antibiotic_resistance ARO:3000757 50S ribosomal subunit P-site ARO:3000757 The P-site of the ribosome binds the peptidyl-tRNA with the growing polypeptide chain, and is a common target for many antibiotics that inhibit the 50S ribosomal subunit. Some antibiotics (oxazolidinones) block the 50S subunit from interacting with the 30S subunit to prevent the formation of the ribosomal complex. Other antibiotics (thiostrepton) block the 50S subunit from interacting with elongation factors G and Tu (EF-G, Ef-Tu), preventing GTP-dependent reactions of peptidyl transferase, and translocation, respectively. Other antibiotics (macrolides) prevent protein translocation. PMID:15700955 PMID:15755955 PMID:795651 Fosmidomycin is an inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, an enzyme in the non-mevalonate pathway for isoprenoid synthesis. It is active against enterobacteria, but not against Gram-positive bacteria or anaerobes. CAS:66508-53-0 ChEBI:443725 ChEMBL:CHEMBL203125 PubChem:572 antibiotic_resistance ARO:3000758 fosmidomycin ARO:3000758 Fosmidomycin is an inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, an enzyme in the non-mevalonate pathway for isoprenoid synthesis. It is active against enterobacteria, but not against Gram-positive bacteria or anaerobes. PMID:10477522 Fusidic acid is the only commercially available fusidane, a group of steroid-like antibiotics. It is most active against Gram-positive bacteria, and acts by inhibiting elongation factor G to block protein synthesis. CAS:6990-06-3 ChEBI:29013 ChEMBL:CHEMBL374975 PubChem:3000226 fucidin antibiotic_resistance ARO:3000759 fusidic acid ARO:3000759 Fusidic acid is the only commercially available fusidane, a group of steroid-like antibiotics. It is most active against Gram-positive bacteria, and acts by inhibiting elongation factor G to block protein synthesis. PMID:17980694 PMID:7730233 Cycloserine is an anti-mycobacterial agent, and is active against enterobacteria, streptococci, M. tuberculosis, Staphylococcus aureus, and many Gram-negative and Gram-positive bacteria. It inhibits cell wall biosynthesis. CAS:68-41-7 ChEBI:40009 ChEMBL:CHEMBL771 PubChem:6234 antibiotic_resistance ARO:3000760 cycloserine ARO:3000760 Cycloserine is an anti-mycobacterial agent, and is active against enterobacteria, streptococci, M. tuberculosis, Staphylococcus aureus, and many Gram-negative and Gram-positive bacteria. It inhibits cell wall biosynthesis. PMID:14479178 PMID:4555420 Mecillinam is a broad-spectrum beta-lactam antibiotic that was semi-synthetically derived to have a different drug centre, being a 6-alpha-amidinopenicillanate instead of a 6-alpha-acylaminopenicillanate. Contrasting most beta-lactam drugs, mecillinam is most active against Gram-negative bacteria. It binds specifically to penicillin binding protein 2 (PBP2). CAS:32887-01-7 ChEBI:51208 ChEMBL:CHEMBL530 PubChem:36273 Selexid Selexidin amdinocillin antibiotic_resistance ARO:3000761 mecillinam ARO:3000761 Mecillinam is a broad-spectrum beta-lactam antibiotic that was semi-synthetically derived to have a different drug centre, being a 6-alpha-amidinopenicillanate instead of a 6-alpha-acylaminopenicillanate. Contrasting most beta-lactam drugs, mecillinam is most active against Gram-negative bacteria. It binds specifically to penicillin binding protein 2 (PBP2). PMID:6310995 Pefloxacin is structurally and functionally similar to norfloxacin. It is poorly active against mycobacteria, while anaerobes are resistant. CAS:70458-92-3 ChEBI:50199 ChEMBL:CHEMBL267648 PubChem:51081 antibiotic_resistance ARO:3000762 pefloxacin ARO:3000762 Pefloxacin is structurally and functionally similar to norfloxacin. It is poorly active against mycobacteria, while anaerobes are resistant. PMID:2663414 EmbC is an arabinosyltransferase involved in lipoarabinomannan synthesis. antibiotic_resistance ARO:3000763 antibiotic sensitive embC ARO:3000763 EmbC is an arabinosyltransferase involved in lipoarabinomannan synthesis. PMID:18174142 EmbA is an arabinosyltransferase that works as a heterodimer with EmbB. It is involved in the synthesis of arabinogalactan, a component of the mycobacterial cell wall. antibiotic_resistance ARO:3000764 antibiotic sensitive embA ARO:3000764 EmbA is an arabinosyltransferase that works as a heterodimer with EmbB. It is involved in the synthesis of arabinogalactan, a component of the mycobacterial cell wall. PMID:18174142 EmbB is an arabinosyltransferase that works as a heterodimer with EmbA. It is involved in the synthesis of arabinogalactan, a component of the mycobacterial cell wall. antibiotic_resistance ARO:3000765 antibiotic sensitive embB ARO:3000765 EmbB is an arabinosyltransferase that works as a heterodimer with EmbA. It is involved in the synthesis of arabinogalactan, a component of the mycobacterial cell wall. PMID:18174142 Topoisomerases are responsible for winding and relaxing supercoiled DNA. The subunits of gyrase (gyrA, gyrB) and topoisomerase IV (parC, parE, parY) are targeted by antibiotics. antibiotic_resistance ARO:3000766 antibiotic sensitive topoisomerase subunit ARO:3000766 Avoparcin is a glycopeptide antibiotic that is an analog of vancomycin. It was formally used to treat animals, but has since been banned because of its selection for vancomycin-resistant enterococci. ChEBI:221101 ChEMBL:CHEMBL2108224 PubChem:16132294 antibiotic_resistance ARO:3000767 avoparcin ARO:3000767 Avoparcin is a glycopeptide antibiotic that is an analog of vancomycin. It was formally used to treat animals, but has since been banned because of its selection for vancomycin-resistant enterococci. PMID:2532132 PMID:9458981 AbeS in an efflux pump of the SMR family of transporters found in Acinetobacter baumannii. abeS antibiotic_resistance ARO:3000768 abeS ARO:3000768 AbeS in an efflux pump of the SMR family of transporters found in Acinetobacter baumannii. PMID:19770280 abeS PatA-PatB is an efflux protein complex that is associated with fluoroquinolone resistance in Streptococcus pneumoniae. Experiments indicate that PatA and PatB form a heterodimeric transporter. PatA-PatB PatA/PatB PatAB antibiotic_resistance ARO:3000769 PatA-PatB ARO:3000769 PatA-PatB is an efflux protein complex that is associated with fluoroquinolone resistance in Streptococcus pneumoniae. Experiments indicate that PatA and PatB form a heterodimeric transporter. PMID:20709735 PMID:20937787 PatA-PatB AdeABC is an RND multidrug efflux system in Acinetobacter species, notably A. baunmannii. AdeA is a membrane fusion protein, AdeB is the inner membrane transporter, and AdeC is the outer membrane factor. It confers resistance to tigecycline. antibiotic_resistance ARO:3000770 AdeABC ARO:3000770 AdeABC is an RND multidrug efflux system in Acinetobacter species, notably A. baunmannii. AdeA is a membrane fusion protein, AdeB is the inner membrane transporter, and AdeC is the outer membrane factor. It confers resistance to tigecycline. PMID:17363424 PMID:21173183 AdeFGH is a RND multidrug efflux pump expressed in Acinetobacter baumannii. It confers resistance to fluoroquinolone, tetracycline, tigecycline, chloramphenicol, clindamycin, trimethoprim, and sulfamethoxazole. antibiotic_resistance ARO:3000771 AdeFGH ARO:3000771 AdeFGH is a RND multidrug efflux pump expressed in Acinetobacter baumannii. It confers resistance to fluoroquinolone, tetracycline, tigecycline, chloramphenicol, clindamycin, trimethoprim, and sulfamethoxazole. PMID:20696879 PMID:21377839 AdeIJK is a RND multidrug efflux pump expressed in Acinetobacter baumannii. It contributes to resistance for beta-lactams, chloramphenicol, tetracycline, erythromycin, lincosamides, fluoroquinolone, fusidic acid, novobiocin, rifampicin, trimethoprim, acridine, pyronine, and safranin. antibiotic_resistance ARO:3000772 AdeIJK ARO:3000772 AdeIJK is a RND multidrug efflux pump expressed in Acinetobacter baumannii. It contributes to resistance for beta-lactams, chloramphenicol, tetracycline, erythromycin, lincosamides, fluoroquinolone, fusidic acid, novobiocin, rifampicin, trimethoprim, acridine, pyronine, and safranin. PMID:18086852 CmeABC is a multidrug efflux pump in Campylobacter jejuni. Its overexpression led to enhanced resistance to ciprofloxacin, norfloxacin, cefotaxime, fusidic acid, and erythromycin. CmeA acts as the periplasmic fusion protein, CmeB is the inner membrane transporter, and CmeC is an outer membrane protein. antibiotic_resistance ARO:3000773 CmeABC ARO:3000773 CmeABC is a multidrug efflux pump in Campylobacter jejuni. Its overexpression led to enhanced resistance to ciprofloxacin, norfloxacin, cefotaxime, fusidic acid, and erythromycin. CmeA acts as the periplasmic fusion protein, CmeB is the inner membrane transporter, and CmeC is an outer membrane protein. PMID:15728904 PMID:27651364 AdeA is the membrane fusion protein of the multidrug efflux complex AdeABC. adeA antibiotic_resistance ARO:3000774 adeA ARO:3000774 AdeA is the membrane fusion protein of the multidrug efflux complex AdeABC. PMID:21173183 adeA AdeB is the multidrug transporter of the adeABC efflux system. adeB antibiotic_resistance ARO:3000775 adeB ARO:3000775 AdeB is the multidrug transporter of the adeABC efflux system. PMID:21173183 adeB AdeF is the membrane fusion protein of the multidrug efflux complex AdeFGH. adeF antibiotic_resistance ARO:3000777 adeF ARO:3000777 AdeF is the membrane fusion protein of the multidrug efflux complex AdeFGH. PMID:20696879 adeF AdeG is the inner membrane transporter of the AdeFGH multidrug efflux complex. adeG antibiotic_resistance ARO:3000778 adeG ARO:3000778 AdeG is the inner membrane transporter of the AdeFGH multidrug efflux complex. PMID:21377839 adeG AdeH is the outer membrane channel protein of the AdeFGH multidrug efflux complex. adeH antibiotic_resistance ARO:3000779 adeH ARO:3000779 AdeH is the outer membrane channel protein of the AdeFGH multidrug efflux complex. PMID:20696879 adeH AdeI is the membrane fusion protein of the AdeIJK multidrug efflux complex. adeI antibiotic_resistance ARO:3000780 adeI ARO:3000780 AdeI is the membrane fusion protein of the AdeIJK multidrug efflux complex. PMID:18086852 adeI AdeJ is a RND efflux protein that acts as the inner membrane transporter of the AdeIJK efflux complex. It has 57% identity with E. coli AcrB. adeJ antibiotic_resistance ARO:3000781 adeJ ARO:3000781 AdeJ is a RND efflux protein that acts as the inner membrane transporter of the AdeIJK efflux complex. It has 57% identity with E. coli AcrB. PMID:18086852 adeJ AdeK is the outer membrane factor protein in the adeIJK multidrug efflux complex. adeK antibiotic_resistance ARO:3000782 adeK ARO:3000782 AdeK is the outer membrane factor protein in the adeIJK multidrug efflux complex. PMID:18086852 adeK CmeA is the membrane fusion protein of the CmeABC multidrug efflux complex. cmeA antibiotic_resistance ARO:3000783 cmeA ARO:3000783 CmeA is the membrane fusion protein of the CmeABC multidrug efflux complex. PMID:15728904 cmeA CmeB is the inner membrane transporter the CmeABC multidrug efflux complex. cmeB antibiotic_resistance ARO:3000784 cmeB ARO:3000784 CmeB is the inner membrane transporter the CmeABC multidrug efflux complex. PMID:15728904 cmeB CmeC is the outer membrane channel protein of the CmeABC multidrug efflux complex. cmeC antibiotic_resistance ARO:3000785 cmeC ARO:3000785 CmeC is the outer membrane channel protein of the CmeABC multidrug efflux complex. PMID:15728904 cmeC MdsABC, or GesABC, is a RND-type efflux complex found in Salmonella. In addition to its metal-efflux system, GesABC is also capable of exporting beta-lactams, chloramphenicol, and thiamphenicol. GesB is the inner membrane transporter and is similar to MexF; GesA is the membrane-fusion protein, and GesC is the outer membrane factor. GesABC STM0352 STM0351 STM0350 antibiotic_resistance ARO:3000786 MdsABC ARO:3000786 MdsABC, or GesABC, is a RND-type efflux complex found in Salmonella. In addition to its metal-efflux system, GesABC is also capable of exporting beta-lactams, chloramphenicol, and thiamphenicol. GesB is the inner membrane transporter and is similar to MexF; GesA is the membrane-fusion protein, and GesC is the outer membrane factor. PMID:17919284 PMID:20497225 MdtABC-TolC is a multidrug efflux system in Gram-negative bacteria, including E. coli and Salmonella. MdtA is a membrane fusion protein; TolC is the outer membrane channel; MdtBC form a drug transporter. In the absence of MdtB, the MdtAC-TolC has narrower drug specificity, leading to the loss of novobiocin resistance, for example. MdtABC-TolC antibiotic_resistance ARO:3000787 MdtABC-TolC ARO:3000787 MdtABC-TolC is a multidrug efflux system in Gram-negative bacteria, including E. coli and Salmonella. MdtA is a membrane fusion protein; TolC is the outer membrane channel; MdtBC form a drug transporter. In the absence of MdtB, the MdtAC-TolC has narrower drug specificity, leading to the loss of novobiocin resistance, for example. PMID:12107133 PMID:17933888 MdtABC-TolC MdtEF-TolC is a multidrug efflux complex in Gram-negative bacteria, including E. coli. MdtE is the membrane fusion protein, MdtF is the inner membrane transporter, while TolC is the outer membrane channel. MdtEF-TolC YhiUV-TolC antibiotic_resistance ARO:3000788 MdtEF-TolC ARO:3000788 MdtEF-TolC is a multidrug efflux complex in Gram-negative bacteria, including E. coli. MdtE is the membrane fusion protein, MdtF is the inner membrane transporter, while TolC is the outer membrane channel. PMID:14973023 MdtEF-TolC MdsA is the membrane fusion protein of the multidrug and metal efflux complex MdsABC. gesA mdsA antibiotic_resistance ARO:3000789 mdsA ARO:3000789 MdsA is the membrane fusion protein of the multidrug and metal efflux complex MdsABC. PMID:17919284 PMID:20497225 mdsA MdsB is the inner membrane transporter of the multidrug and metal efflux complex MdsABC. mdsB corresponds to 1 locus in Pseudomonas aeruginosa PAO1 (gene name: mexQ) and 2 loci in Pseudomonas aeruginosa LESB58. gesB mdsB antibiotic_resistance ARO:3000790 mdsB ARO:3000790 MdsB is the inner membrane transporter of the multidrug and metal efflux complex MdsABC. mdsB corresponds to 1 locus in Pseudomonas aeruginosa PAO1 (gene name: mexQ) and 2 loci in Pseudomonas aeruginosa LESB58. PMID:17919284 PMID:20497225 mdsB MdsC is the outer membrane channel of the multidrug and metal efflux complex MdsABC. gesC mdsC antibiotic_resistance ARO:3000791 mdsC ARO:3000791 MdsC is the outer membrane channel of the multidrug and metal efflux complex MdsABC. PMID:17919284 PMID:20497225 mdsC MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC. mdtA yegM antibiotic_resistance ARO:3000792 mdtA ARO:3000792 MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC. PMID:12107133 mdtA MdtB is a transporter that forms a heteromultimer complex with MdtC to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex. mdtB yegN antibiotic_resistance ARO:3000793 mdtB ARO:3000793 MdtB is a transporter that forms a heteromultimer complex with MdtC to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex. PMID:12107133 mdtB MdtC is a transporter that forms a heteromultimer complex with MdtB to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex. In the absence of MdtB, MdtC can form a homomultimer complex that results in a functioning efflux complex with a narrower drug specificity. mdtC corresponds to 3 loci in Pseudomonas aeruginosa PAO1 (gene name: muxC/muxB) and 3 loci in Pseudomonas aeruginosa LESB58. mdtC yegO antibiotic_resistance ARO:3000794 mdtC ARO:3000794 MdtC is a transporter that forms a heteromultimer complex with MdtB to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex. In the absence of MdtB, MdtC can form a homomultimer complex that results in a functioning efflux complex with a narrower drug specificity. mdtC corresponds to 3 loci in Pseudomonas aeruginosa PAO1 (gene name: muxC/muxB) and 3 loci in Pseudomonas aeruginosa LESB58. PMID:12107133 mdtC MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. YhiU mdtE antibiotic_resistance ARO:3000795 mdtE ARO:3000795 MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA. PMID:23380871 mdtE MdtF is the multidrug inner membrane transporter for the MdtEF-TolC efflux complex. YhiV mdtF antibiotic_resistance ARO:3000796 mdtF ARO:3000796 MdtF is the multidrug inner membrane transporter for the MdtEF-TolC efflux complex. PMID:11914367 mdtF MexCD-OprJ is a multidrug efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexC is the membrane fusion protein; MexD is the inner membrane transporter; and OprJ is the outer membrane channel. MexAB-OprM is associated with resistance to fluoroquinolones, chloramphenicol, and macrolides. MexCD-OprJ is typically quiescent in wild-type cells, with expression following mutation of the nfxB gene that is divergently transcribed from the mexCD-oprJ operon and encodes a repressor of mexCD-oprJ expression. Expression of mexCD–oprJ is controlled by a single known regulator, the NfxB repressor encoded by the nfxB gene, which is transcribed divergently from the efflux genes. antibiotic_resistance ARO:3000797 MexCD-OprJ ARO:3000797 MexCD-OprJ is a multidrug efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexC is the membrane fusion protein; MexD is the inner membrane transporter; and OprJ is the outer membrane channel. MexAB-OprM is associated with resistance to fluoroquinolones, chloramphenicol, and macrolides. MexCD-OprJ is typically quiescent in wild-type cells, with expression following mutation of the nfxB gene that is divergently transcribed from the mexCD-oprJ operon and encodes a repressor of mexCD-oprJ expression. Expression of mexCD–oprJ is controlled by a single known regulator, the NfxB repressor encoded by the nfxB gene, which is transcribed divergently from the efflux genes. PMID:9449262 MexEF-OprN is a multidrug efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexE is the membrane fusion protein; MexF is the inner membrane transporter; and OprN is the outer membrane channel. MexEF-OprN is associated with resistance to fluoroquinolones, chloramphenicol, and trimethoprim. Regulation of mexEF-oprN operon expression is multifaceted with the MexT activator being one of the most prominent regulatory proteins. MexEF-OprN is the only positively regulated RND pump of P. aeruginosa. antibiotic_resistance ARO:3000798 MexEF-OprN ARO:3000798 MexEF-OprN is a multidrug efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexE is the membrane fusion protein; MexF is the inner membrane transporter; and OprN is the outer membrane channel. MexEF-OprN is associated with resistance to fluoroquinolones, chloramphenicol, and trimethoprim. Regulation of mexEF-oprN operon expression is multifaceted with the MexT activator being one of the most prominent regulatory proteins. MexEF-OprN is the only positively regulated RND pump of P. aeruginosa. PMID:10515918 MexGHI-OpmD is an efflux complex expressed in Pseudomonas aeruginosa. MexG is a membrane protein required for drug export; MexH is the membrane fusion protein; MexI is the inner membrane transporter; and MexJ is the outer membrane channel protein. MexGHI-OpmD confers resistance to vanadium, norfloxacin, and acriflavin. MexGHI-OmpD MexGHI-OpmD antibiotic_resistance ARO:3000799 MexGHI-OpmD ARO:3000799 MexGHI-OpmD is an efflux complex expressed in Pseudomonas aeruginosa. MexG is a membrane protein required for drug export; MexH is the membrane fusion protein; MexI is the inner membrane transporter; and MexJ is the outer membrane channel protein. MexGHI-OpmD confers resistance to vanadium, norfloxacin, and acriflavin. PMID:12917802 PMID:15817779 MexGHI-OpmD MexC is the membrane fusion protein of the MexCD-OprJ multidrug efflux complex. MexC antibiotic_resistance ARO:3000800 MexC ARO:3000800 MexC is the membrane fusion protein of the MexCD-OprJ multidrug efflux complex. PMID:9449262 MexC MexD is the multidrug inner membrane transporter of the MexCD-OprJ complex. MexD antibiotic_resistance ARO:3000801 MexD ARO:3000801 MexD is the multidrug inner membrane transporter of the MexCD-OprJ complex. PMID:8878035 PMID:9449262 MexD OprJ is the outer membrane channel component of the MexCD-OprJ multidrug efflux complex. OprJ antibiotic_resistance ARO:3000802 OprJ ARO:3000802 OprJ is the outer membrane channel component of the MexCD-OprJ multidrug efflux complex. PMID:9449262 OprJ MexE is the membrane fusion protein of the MexEF-OprN multidrug efflux complex. MexE antibiotic_resistance ARO:3000803 MexE ARO:3000803 MexE is the membrane fusion protein of the MexEF-OprN multidrug efflux complex. PMID:10515918 MexE MexF is the multidrug inner membrane transporter of the MexEF-OprN complex. mexF corresponds to 2 loci in Pseudomonas aeruginosa PAO1 (gene name: mexF/mexB) and 4 loci in Pseudomonas aeruginosa LESB58 (gene name: mexD/mexB). MexF antibiotic_resistance ARO:3000804 MexF ARO:3000804 MexF is the multidrug inner membrane transporter of the MexEF-OprN complex. mexF corresponds to 2 loci in Pseudomonas aeruginosa PAO1 (gene name: mexF/mexB) and 4 loci in Pseudomonas aeruginosa LESB58 (gene name: mexD/mexB). PMID:10515918 MexF OprN is the outer membrane channel component of the MexEF-OprN multidrug efflux complex. OprN antibiotic_resistance ARO:3000805 OprN ARO:3000805 OprN is the outer membrane channel component of the MexEF-OprN multidrug efflux complex. PMID:10515918 OprN MexG is a membrane protein required for MexGHI-OpmD efflux activity. MexG antibiotic_resistance ARO:3000806 MexG ARO:3000806 MexG is a membrane protein required for MexGHI-OpmD efflux activity. PMID:12917802 PMID:15817779 MexG MexH is the membrane fusion protein of the efflux complex MexGHI-OpmD. MexH antibiotic_resistance ARO:3000807 MexH ARO:3000807 MexH is the membrane fusion protein of the efflux complex MexGHI-OpmD. PMID:12917802 PMID:15817779 MexH MexI is the inner membrane transporter of the efflux complex MexGHI-OpmD. MexI antibiotic_resistance ARO:3000808 MexI ARO:3000808 MexI is the inner membrane transporter of the efflux complex MexGHI-OpmD. PMID:12917802 PMID:15817779 MexI OpmD is the outer membrane channel protein of the efflux complex MexGHI-OpmD. OpmD ompD antibiotic_resistance ARO:3000809 OpmD ARO:3000809 OpmD is the outer membrane channel protein of the efflux complex MexGHI-OpmD. PMID:12177331 PMID:12917802 PMID:12937010 PMID:15817779 OpmD MtrC is the membrane fusion protein of the MtrCDE multidrug efflux complex. mtrC antibiotic_resistance ARO:3000810 mtrC ARO:3000810 MtrC is the membrane fusion protein of the MtrCDE multidrug efflux complex. PMID:14500476 mtrC MtrD is the inner membrane multidrug transporter of the MtrCDE efflux complex. mtrD antibiotic_resistance ARO:3000811 mtrD ARO:3000811 MtrD is the inner membrane multidrug transporter of the MtrCDE efflux complex. PMID:14500476 PMID:9245801 mtrD MtrE is an outer membrane exporter protein that is part of the MtrCDE multidrug efflux complex. mtrE antibiotic_resistance ARO:3000812 mtrE ARO:3000812 MtrE is an outer membrane exporter protein that is part of the MtrCDE multidrug efflux complex. PMID:14500476 mtrE MexS is a suppressor of MexT, which is an activator of the multidrug pump MexEF-OprN. Mutations in MexS lead to multidrug resistance. MexS PA2491 nfxC qrh antibiotic_resistance ARO:3000813 MexS ARO:3000813 MexS is a suppressor of MexT, which is an activator of the multidrug pump MexEF-OprN. Mutations in MexS lead to multidrug resistance. PMID:11040437 PMID:15687188 PMID:26833155 MexS MexT is a LysR-type transcriptional activator that positively regulates the expression of MexEF-OprN, OprD, and MexS. MexT antibiotic_resistance ARO:3000814 MexT ARO:3000814 MexT is a LysR-type transcriptional activator that positively regulates the expression of MexEF-OprN, OprD, and MexS. PMID:10515918 PMID:11040437 PMID:26833155 MexT MgrA, also known as NorR, is a regulator for norA, norB, and tet38. It is a positive regulator for norA expression, but is a direct repressor for norB and an indirect repressor of tet38. mgrA norR antibiotic_resistance ARO:3000815 mgrA ARO:3000815 MgrA, also known as NorR, is a regulator for norA, norB, and tet38. It is a positive regulator for norA expression, but is a direct repressor for norB and an indirect repressor of tet38. PMID:12730173 PMID:15774883 mgrA MtrA is a transcriptional activator of the MtrCDE multidrug efflux pump of Neisseria gonorrhoeae. mtrA antibiotic_resistance ARO:3000816 mtrA ARO:3000816 MtrA is a transcriptional activator of the MtrCDE multidrug efflux pump of Neisseria gonorrhoeae. PMID:10417654 mtrA MtrR is a repressor of mtrCDE expression. Mutations in mtrR increase multidrug resistance. mtrR antibiotic_resistance ARO:3000817 mtrR ARO:3000817 MtrR is a repressor of mtrCDE expression. Mutations in mtrR increase multidrug resistance. PMID:7773394 mtrR NalC is a repressor of PA3720-PA3719, which are positive regulators of MexAB-OprM. Thus, nalC mutants confer multidrug resistance. PA3721 nalC antibiotic_resistance ARO:3000818 nalC ARO:3000818 NalC is a repressor of PA3720-PA3719, which are positive regulators of MexAB-OprM. Thus, nalC mutants confer multidrug resistance. PMID:15387820 PMID:27060003 PMID:27412168 nalC NalD is a repressor of MexAB-OprM. Mutations lead to multidrug resistance and MexAB-OprM overexpression. PA3574 nalD antibiotic_resistance ARO:3000819 nalD ARO:3000819 NalD is a repressor of MexAB-OprM. Mutations lead to multidrug resistance and MexAB-OprM overexpression. PMID:15855496 nalD NfxB is a repressor of the efflux pump mexCD-oprJ and itself (NfxB binds upstream of the nfxB gene and negatively regulates its own expression). Increased expression of MexCD–OprJ brought about by mutations in NfxB. antibiotic_resistance ARO:3000820 NfxB ARO:3000820 NfxB is a repressor of the efflux pump mexCD-oprJ and itself (NfxB binds upstream of the nfxB gene and negatively regulates its own expression). Increased expression of MexCD–OprJ brought about by mutations in NfxB. PMID:12727072 PMID:1330820 PMID:23924707 PMID:8878035 PhoPQ is a two-component regulatory system. phoP is phosphorylated by phoQ at a low [mg2+], activating the repressor. Its part of a two component regulating system that activates the PmrA/B system which has downstream effects, leading to Antimicrobial resistance in many pathogens. In Salmonella, phoP bind to macAB ABC transporter and represses it. In Escherichia coli, phoPQ regulates arnA expression. In Pseudomonas aeruginosa, phoPQ regulates OprH expression. phoPQ have other roles in other species. PhoP/Q antibiotic_resistance ARO:3000821 phoPQ ARO:3000821 PhoPQ is a two-component regulatory system. phoP is phosphorylated by phoQ at a low [mg2+], activating the repressor. Its part of a two component regulating system that activates the PmrA/B system which has downstream effects, leading to Antimicrobial resistance in many pathogens. In Salmonella, phoP bind to macAB ABC transporter and represses it. In Escherichia coli, phoPQ regulates arnA expression. In Pseudomonas aeruginosa, phoPQ regulates OprH expression. phoPQ have other roles in other species. PMID:11222580 PMID:16359323 PMID:20843473 PMID:21131322 PmrA is a MFS-type efflux pump expressed in Streptococcus pneumoniae that confers low-level resistance to norfloxacin, ciprofloxacin, and acriflavine. pmrA antibiotic_resistance ARO:3000822 pmrA ARO:3000822 PmrA is a MFS-type efflux pump expressed in Streptococcus pneumoniae that confers low-level resistance to norfloxacin, ciprofloxacin, and acriflavine. PMID:11850265 PMID:15205413 PMID:20709735 PMID:9869592 pmrA RamA (resistance antibiotic multiple) is a positive regulator of AcrAB-TolC and leads to high level multidrug resistance in Klebsiella pneumoniae, Salmonella enterica, and Enterobacter aerugenes, increasing the expression of both the mar operon as well as AcrAB. RamA also decreases OmpF expression. ramA antibiotic_resistance ARO:3000823 ramA ARO:3000823 RamA (resistance antibiotic multiple) is a positive regulator of AcrAB-TolC and leads to high level multidrug resistance in Klebsiella pneumoniae, Salmonella enterica, and Enterobacter aerugenes, increasing the expression of both the mar operon as well as AcrAB. RamA also decreases OmpF expression. PMID:12936981 PMID:15215103 PMID:18577510 PMID:7551053 ramA RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA. antibiotic_resistance ARO:3000824 ramR ARO:3000824 RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA. PMID:18443112 PMID:19104017 PMID:19270312 PMID:19778917 The robA protein is a positive regulator for the acrAB efflux genes, and is structurally similar to SoxS and MarA. robA antibiotic_resistance ARO:3000825 rob ARO:3000825 The robA protein is a positive regulator for the acrAB efflux genes, and is structurally similar to SoxS and MarA. PMID:12791142 PMID:9324261 SdiA is a cell division regulator that is also a positive regulator of AcrAB only when it's expressed from a plasmid. When the sdiA gene is on the chromosome, it has no effect on expression of acrAB. sdiA antibiotic_resistance ARO:3000826 sdiA ARO:3000826 SdiA is a cell division regulator that is also a positive regulator of AcrAB only when it's expressed from a plasmid. When the sdiA gene is on the chromosome, it has no effect on expression of acrAB. PMID:11929524 PMID:20126629 sdiA SoxRS is a two-component regulator part of the superoxide stress response. It is a positive regulator for many multidrug efflux pumps. antibiotic_resistance ARO:3000827 soxRS ARO:3000827 SoxRS is a two-component regulator part of the superoxide stress response. It is a positive regulator for many multidrug efflux pumps. PMID:7986007 BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes. baeR antibiotic_resistance ARO:3000828 baeR ARO:3000828 BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes. PMID:12107133 PMID:37345941 baeR BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity, BaeS is not necessary for overexpressed BaeR to confer resistance. baeS antibiotic_resistance ARO:3000829 baeS ARO:3000829 BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity, BaeS is not necessary for overexpressed BaeR to confer resistance. PMID:12107134 PMID:15716448 PMID:37345941 baeS CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR, which promotes efflux complex expression. cpxA antibiotic_resistance ARO:3000830 cpxA ARO:3000830 CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR, which promotes efflux complex expression. PMID:22496764 cpxA CpxR is a regulator that promotes acrD expression when phosphorylated by a cascade involving CpxA, a sensor kinase. CpxR is also directly involved in activation of expression of RND efflux pump MexAB-OprM in P. aeruginosa. CpxR is required to enhance mexAB-oprM expression and drug resistance, in the absence of repressor MexR. antibiotic_resistance ARO:3000831 CpxR ARO:3000831 CpxR is a regulator that promotes acrD expression when phosphorylated by a cascade involving CpxA, a sensor kinase. CpxR is also directly involved in activation of expression of RND efflux pump MexAB-OprM in P. aeruginosa. CpxR is required to enhance mexAB-oprM expression and drug resistance, in the absence of repressor MexR. PMID:22496764 PMID:25294881 PMID:27736975 EvgA, when phosphorylated, is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner, it can be phosphorylated in the absence of EvgS when overexpressed. evgA antibiotic_resistance ARO:3000832 evgA ARO:3000832 EvgA, when phosphorylated, is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner, it can be phosphorylated in the absence of EvgS when overexpressed. PMID:12951338 evgA EvgS is a sensor protein that phosphorylates the regulatory protein EvgA. evgS corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. evgS rocS1 antibiotic_resistance ARO:3000833 evgS ARO:3000833 EvgS is a sensor protein that phosphorylates the regulatory protein EvgA. evgS corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. PMID:11914367 evgS PhoP is a direct repressor of the macAB efflux genes. antibiotic_resistance ARO:3000834 phoP ARO:3000834 PhoP is a direct repressor of the macAB efflux genes. PMID:24412662 PhoQ is a sensor protein that is induced by low Mg2+ concentrations. When activated, PhoQ donates a phosphate to activate PhoP. antibiotic_resistance ARO:3000835 phoQ ARO:3000835 PhoQ is a sensor protein that is induced by low Mg2+ concentrations. When activated, PhoQ donates a phosphate to activate PhoP. PMID:24412662 SoxR is a sensory protein that upregulates soxS expression in the presence of redox-cycling drugs. This stress response leads to the expression many multidrug efflux pumps. In Pseudomonas aeruginosa, which lacks SoxS, SoxR is able to directly upregulate the expression of the MexGHI-OpmD efflux pump. antibiotic_resistance ARO:3000836 soxR ARO:3000836 SoxR is a sensory protein that upregulates soxS expression in the presence of redox-cycling drugs. This stress response leads to the expression many multidrug efflux pumps. In Pseudomonas aeruginosa, which lacks SoxS, SoxR is able to directly upregulate the expression of the MexGHI-OpmD efflux pump. PMID:15845502 PMID:21226770 SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability. antibiotic_resistance ARO:3000837 soxS ARO:3000837 SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability. PMID:15845502 PMID:7986007 PMID:8821940 PMID:9324261 ArlR is a response regulator that binds to the norA promoter to activate expression. ArlR must first be phosphorylated by ArlS. arlR antibiotic_resistance ARO:3000838 arlR ARO:3000838 ArlR is a response regulator that binds to the norA promoter to activate expression. ArlR must first be phosphorylated by ArlS. PMID:10633099 arlR ArlS is a protein histidine kinase that phosphorylates ArlR, a promoter for norA expression. arlS antibiotic_resistance ARO:3000839 arlS ARO:3000839 ArlS is a protein histidine kinase that phosphorylates ArlR, a promoter for norA expression. PMID:10633099 arlS JOHN-1 is an Ambler class B carbapenem-hydrolysing beta-lactamase from Flavobacterium johnsoniae. JOHN-1 antibiotic_resistance ARO:3000840 JOHN-1 ARO:3000840 JOHN-1 is an Ambler class B carbapenem-hydrolysing beta-lactamase from Flavobacterium johnsoniae. PMID:12562690 JOHN-1 CGB-1 is an Ambler class B beta-lactamase that mediates resistance for carbapenems in Chryseobacterium gleum. CGB-1 antibiotic_resistance ARO:3000841 CGB-1 ARO:3000841 CGB-1 is an Ambler class B beta-lactamase that mediates resistance for carbapenems in Chryseobacterium gleum. PMID:12183230 CGB-1 EBR-1 is an Ambler class B beta-lactamase found in Empedobacter brevis and is known to mediate the hydrolysis of penicillins, cephalosporins, and carbapenems efficiently but not aztreonam. EBR-1 antibiotic_resistance ARO:3000842 EBR-1 ARO:3000842 EBR-1 is an Ambler class B beta-lactamase found in Empedobacter brevis and is known to mediate the hydrolysis of penicillins, cephalosporins, and carbapenems efficiently but not aztreonam. PMID:12234848 EBR-1 MUS-1 is a chromosome-encoded beta-lactamase from Myroides odoratus and Myroides odoratimimus. MUS-1 antibiotic_resistance ARO:3000843 MUS-1 ARO:3000843 MUS-1 is a chromosome-encoded beta-lactamase from Myroides odoratus and Myroides odoratimimus. PMID:12384365 MUS-1 TUS-1 is a chromosome-encoded beta-lactamase from Myroides odoratus and Myroides odoratimimus. TUS-1 antibiotic_resistance ARO:3000844 TUS-1 ARO:3000844 TUS-1 is a chromosome-encoded beta-lactamase from Myroides odoratus and Myroides odoratimimus. PMID:12384365 TUS-1 GIM-1 is an integron-encoded B1 beta-lactamase found in Pseudomonas aeruginosa. GIM-1 antibiotic_resistance ARO:3000845 GIM-1 ARO:3000845 GIM-1 is an integron-encoded B1 beta-lactamase found in Pseudomonas aeruginosa. PMID:15561840 GIM-1 SIM-1 is an integron-encoded Ambler class B beta-lactamase isolated from Acinetobacter baumannii. SIM-1 antibiotic_resistance ARO:3000846 SIM-1 ARO:3000846 SIM-1 is an integron-encoded Ambler class B beta-lactamase isolated from Acinetobacter baumannii. PMID:16251286 SIM-1 KHM-1 is a plasmid-mediated metallo-beta-lactamase found in Citrobacter freundii that confers resistance to all broad-spectrum beta-lactams, execpt for monobactams. KHM-1 antibiotic_resistance ARO:3000847 KHM-1 ARO:3000847 KHM-1 is a plasmid-mediated metallo-beta-lactamase found in Citrobacter freundii that confers resistance to all broad-spectrum beta-lactams, execpt for monobactams. PMID:18765691 KHM-1 Dutch imipenemase or DIM-1 is an integron-encoded metallo-beta-lactamase from Pseudomonas stutzeri. DIM-1 antibiotic_resistance ARO:3000848 DIM-1 ARO:3000848 Dutch imipenemase or DIM-1 is an integron-encoded metallo-beta-lactamase from Pseudomonas stutzeri. PMID:20308383 DIM-1 SFH-1 confers resistance to carbapenems in Serratia fonticola. SFH-1 antibiotic_resistance ARO:3000849 SFH-1 ARO:3000849 SFH-1 confers resistance to carbapenems in Serratia fonticola. PMID:12821491 SFH-1 GOB-1 confers resistance to cephalosporins in Elizabethkingia (Chryseobacterium) meningoseptica. GOB-1 antibiotic_resistance ARO:3000850 GOB-1 ARO:3000850 GOB-1 confers resistance to cephalosporins in Elizabethkingia (Chryseobacterium) meningoseptica. PMID:10858348 GOB-1 THIN-B, isolated from Janthinobacterium lividum, hydrolyzes a broad spectrum of beta-lactams including penicillins, cephalosporins, and carbapenems. THIN-B antibiotic_resistance ARO:3000851 THIN-B ARO:3000851 THIN-B, isolated from Janthinobacterium lividum, hydrolyzes a broad spectrum of beta-lactams including penicillins, cephalosporins, and carbapenems. PMID:15561856 THIN-B AIM-1 is an Ambler class B beta-lactamase that hydrolyzes most beta-lactams except aztreonam and ceftazidime. It was isolated from Pseudomonas aeruginosa and was the first subclass B3 mobile-elements encoded beta-lactamase discovered. AIM-1 antibiotic_resistance ARO:3000853 AIM-1 ARO:3000853 AIM-1 is an Ambler class B beta-lactamase that hydrolyzes most beta-lactams except aztreonam and ceftazidime. It was isolated from Pseudomonas aeruginosa and was the first subclass B3 mobile-elements encoded beta-lactamase discovered. PMID:22985886 AIM-1 SMB-1 can hydrolyze a variety of beta-lactams, including penicillins, cephalosporins, and carbapenems. It was identified in Serratia marcescens. SMB-1 antibiotic_resistance ARO:3000854 SMB-1 ARO:3000854 SMB-1 can hydrolyze a variety of beta-lactams, including penicillins, cephalosporins, and carbapenems. It was identified in Serratia marcescens. PMID:22442240 SMB-1 CAU-1 is a B3 metallo-beta-lactamase that is encoded by the Caulobacter crescentus chromosome. CAU-1 antibiotic_resistance ARO:3000855 CAU-1 ARO:3000855 CAU-1 is a B3 metallo-beta-lactamase that is encoded by the Caulobacter crescentus chromosome. PMID:12019096 CAU-1 BJP-1 is a subclass B3 ortholog found in Bradyrhizobium japonicum that hydrolyzes most beta-lactams except aztreonam, ticarcillin, and temocillin. BJP-1 antibiotic_resistance ARO:3000856 BJP-1 ARO:3000856 BJP-1 is a subclass B3 ortholog found in Bradyrhizobium japonicum that hydrolyzes most beta-lactams except aztreonam, ticarcillin, and temocillin. PMID:16723554 BJP-1 Methyltransferases that modify the 16S rRNA of the 30S subunit of bacterial ribosomes, conferring resistance to drugs that target 16S rRNA. antibiotic_resistance ARO:3000857 16S ribosomal RNA methyltransferase ARO:3000857 Methyltransferases that modify the 16S rRNA of the 30S subunit of bacterial ribosomes, conferring resistance to drugs that target 16S rRNA. PMID:14667745 PMID:21177880 PMID:22547620 ArmA is a 16S rRNA methyltransferase that targets mature or nearly mature 30S subunits. It transfers a methyl group from S-adenosyl-L-methionine to N7-G1405 of the 16S rRNA, an aminoglycoside binding site. PDB:3FZG armA antibiotic_resistance ARO:3000858 armA ARO:3000858 ArmA is a 16S rRNA methyltransferase that targets mature or nearly mature 30S subunits. It transfers a methyl group from S-adenosyl-L-methionine to N7-G1405 of the 16S rRNA, an aminoglycoside binding site. PMID:19303884 PMID:20926221 PMID:21177880 PMID:27885285 armA RmtA is a 16S rRNA methyltransferase found in Pseudomonas aeruginosa which methylates G1405 of the 16S rRNA. It confers high level resistance to many aminoglycosides. rmtA antibiotic_resistance ARO:3000859 rmtA ARO:3000859 RmtA is a 16S rRNA methyltransferase found in Pseudomonas aeruginosa which methylates G1405 of the 16S rRNA. It confers high level resistance to many aminoglycosides. PMID:14667745 rmtA RmtB is a 16S rRNA methyltransferase that targets mature or nearly mature 30S subunits. It transfers a methyl group from S-adenosyl-L-methionine to N7-G1405 of the 16S rRNA, an aminoglycoside binding site. PDB:3FRH rmtB antibiotic_resistance ARO:3000860 rmtB ARO:3000860 RmtB is a 16S rRNA methyltransferase that targets mature or nearly mature 30S subunits. It transfers a methyl group from S-adenosyl-L-methionine to N7-G1405 of the 16S rRNA, an aminoglycoside binding site. PMID:19303884 PMID:20614151 rmtB RmtC is a rRNA methyltransferase found in Proteus mirabilis with high level resistance to similar to aminoglycosides, with the exception of non-4,6-disubstituted deoxystreptamines (streptomycin and neomycin). It has also been isolated in Salmonella enterica ser. Virchow. It is hypothesized to methylate G1405, like related methyltransferases RmtA, RmtB, and ArmA. rmtC antibiotic_resistance ARO:3000861 rmtC ARO:3000861 RmtC is a rRNA methyltransferase found in Proteus mirabilis with high level resistance to similar to aminoglycosides, with the exception of non-4,6-disubstituted deoxystreptamines (streptomycin and neomycin). It has also been isolated in Salmonella enterica ser. Virchow. It is hypothesized to methylate G1405, like related methyltransferases RmtA, RmtB, and ArmA. PMID:16377684 PMID:20350396 PMID:21177880 PMID:26488937 rmtC Sgm, or sisomicin-gentamicin methyltransferase, methylates G1405 of 16S rRNA to confer resistance to various aminoglycosides. PDB:3LCV sgm antibiotic_resistance ARO:3000862 sgm ARO:3000862 Sgm, or sisomicin-gentamicin methyltransferase, methylates G1405 of 16S rRNA to confer resistance to various aminoglycosides. PMID:20194115 sgm MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface of both Gram-positive and Gram-negative bacteria. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. antibiotic_resistance ARO:3000863 defensin resistant mprF ARO:3000863 MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface of both Gram-positive and Gram-negative bacteria. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. PMID:14769468 PMID:19915718 PMID:20498310 Point mutations in DNA gyrase subunit B (gyrB) observed in Mycobacterium tuberculosis can result in resistance to fluoroquinolones. antibiotic_resistance ARO:3000864 fluoroquinolone resistant gyrB ARO:3000864 Point mutations in DNA gyrase subunit B (gyrB) observed in Mycobacterium tuberculosis can result in resistance to fluoroquinolones. PMID:22279180 OleD is a glycotransferase found in Streptomyces antibioticus, a natural producer of oleandomycin. OleD can glycosylate a wide range of macrolides. Unlike oleI, oleD is not found in the oleandomycin biosynthetic cluster. PDB:2IYF oleD antibiotic_resistance ARO:3000865 oleD ARO:3000865 OleD is a glycotransferase found in Streptomyces antibioticus, a natural producer of oleandomycin. OleD can glycosylate a wide range of macrolides. Unlike oleI, oleD is not found in the oleandomycin biosynthetic cluster. PMID:10766792 PMID:17376874 PMID:8244027 oleD OleI is a glycosyltransferase found in Streptomyces antibioticus, specifically the oleandomycin biosynthetic cluster. OleI glycosylates oleandomycin to confer self-resistance. PDB:2IYA oleI antibiotic_resistance ARO:3000866 oleI ARO:3000866 OleI is a glycosyltransferase found in Streptomyces antibioticus, specifically the oleandomycin biosynthetic cluster. OleI glycosylates oleandomycin to confer self-resistance. PMID:17376874 oleI Oleandomycin is a 14-membered macrolide produced by Streptomyces antibioticus. It is ssimilar to erythromycin, and contains a desosamine amino sugar and an oleandrose sugar. It targets the 50S ribosomal subunit to prevent protein synthesis. CAS:3922-90-5 ChEBI:16869 ChEMBL:CHEMBL606258 PubChem:72493 Amimycin Matromycin antibiotic_resistance ARO:3000867 oleandomycin ARO:3000867 AcetylCoA dependent acetyltransferase that acetylate streptothricins such as nourseothricin at position 16 (beta position of beta-lysine). antibiotic_resistance ARO:3000869 streptothricin acetyltransferase (SAT) ARO:3000869 AcetylCoA dependent acetyltransferase that acetylate streptothricins such as nourseothricin at position 16 (beta position of beta-lysine). PMID:3624064 PMID:8394835 Triclosan is a common antibacterial agent added to many consumer products as a biocide. It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI). CAS:3380-34-5 ChEBI:164200 ChEMBL:CHEMBL849 PubChem:5564 antibiotic_resistance ARO:3000870 triclosan ARO:3000870 Triclosan is a common antibacterial agent added to many consumer products as a biocide. It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI). PMID:10196195 PMID:19768684 Antibiotics can target bacteria-specific fatty acid biosynthesis enzymes. antibiotic_resistance ARO:3000871 fatty acid synthesis enzyme targeted by antibiotic ARO:3000871 Antibiotics can target bacteria-specific fatty acid biosynthesis enzymes. PMID:14736233 Enoyl-acyl carrier reductases catalyze the final enoyl reduction step in bacterial type II fatty acid elongation. Triclosan antibiotics block enoyl reduction and therefore fatty acid synthesis, functioning as a broad spectrum biocide and antibiotic. antibiotic_resistance ARO:3000872 antibiotic sensitive enoyl-acyl carrier reductase ARO:3000872 Enoyl-acyl carrier reductases catalyze the final enoyl reduction step in bacterial type II fatty acid elongation. Triclosan antibiotics block enoyl reduction and therefore fatty acid synthesis, functioning as a broad spectrum biocide and antibiotic. PMID:14736233 TEM-1 is a broad-spectrum beta-lactamase found in many Gram-negative bacteria. Confers resistance to penicillins and first generation cephalosphorins. RTEM-1 TEM-1 TEM-1B antibiotic_resistance ARO:3000873 TEM-1 ARO:3000873 TEM-1 is a broad-spectrum beta-lactamase found in many Gram-negative bacteria. Confers resistance to penicillins and first generation cephalosphorins. PMID:20412308 PMID:33416461 PMID:358200 PMID:5326330 TEM-1 TEM-2 is a broad-spectrum beta-lactamase. TEM-2 antibiotic_resistance ARO:3000874 TEM-2 ARO:3000874 TEM-2 is a broad-spectrum beta-lactamase. PMID:1107329 PMID:358199 TEM-2 TEM-3 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. CTX-1 TEM-14 TEM-3 antibiotic_resistance ARO:3000875 TEM-3 ARO:3000875 TEM-3 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:2550326 PMID:3316146 TEM-3 TEM-4 is an extended-spectrum beta-lactamase that has been found in clinical isolates. TEM-4 antibiotic_resistance ARO:3000876 TEM-4 ARO:3000876 TEM-4 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:2550326 PMID:2692515 TEM-4 TEM-5 is an extended-spectrum beta-lactamase that has been found in clinical isolates. CAZ-1 TEM-5 antibiotic_resistance ARO:3000877 TEM-5 ARO:3000877 TEM-5 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:2550326 PMID:3293523 TEM-5 TEM-6 is an extended-spectrum beta-lactamase found in E. coli. TEM-6 antibiotic_resistance ARO:3000878 TEM-6 ARO:3000878 TEM-6 is an extended-spectrum beta-lactamase found in E. coli. PMID:3312022 TEM-6 TEM-7 is an extended-spectrum beta-lactamase that has been found in clinical isolates. TEM-7 antibiotic_resistance ARO:3000879 TEM-7 ARO:3000879 TEM-7 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:2506109 PMID:3055178 TEM-7 TEM-8 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. CAZ-2 TEM-8 antibiotic_resistance ARO:3000880 TEM-8 ARO:3000880 TEM-8 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:1416873 PMID:2558614 PMID:9925535 TEM-8 TEM-9 is an extended-spectrum beta-lactamase that has been found in clinical isolates. RHH-1 TEM-9 antibiotic_resistance ARO:3000881 TEM-9 ARO:3000881 TEM-9 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:3312022 PMID:3326875 TEM-9 TEM-10 is an extended-spectrum beta-lactamase round in Morganella morganii. MGH-1 TEM-10 TEM-23 TEM-E3 antibiotic_resistance ARO:3000882 TEM-10 ARO:3000882 TEM-10 is an extended-spectrum beta-lactamase round in Morganella morganii. PMID:2684007 PMID:8109951 PMID:9925535 TEM-10 TEM-11 is an extended-spectrum beta-lactamase found in Proteus mirabilis. CAZ-lo TEM-11 antibiotic_resistance ARO:3000883 TEM-11 ARO:3000883 TEM-11 is an extended-spectrum beta-lactamase found in Proteus mirabilis. PMID:2665644 PMID:9925535 TEM-11 TEM-12 is an extended-spectrum beta-lactamase found in Klebsiella oxytoca. CAZ-3 TEM-12 TEM-26b TEM-E2 YOU-2 antibiotic_resistance ARO:3000884 TEM-12 ARO:3000884 TEM-12 is an extended-spectrum beta-lactamase found in Klebsiella oxytoca. PMID:2197339 PMID:7840586 PMID:9925535 TEM-12 TEM-13 is a broad-spectrum beta-lactamase that has been found in clinical isolates. Sequence data unavailable. antibiotic_resistance ARO:3000885 TEM-13 ARO:3000885 TEM-13 is a broad-spectrum beta-lactamase that has been found in clinical isolates. Sequence data unavailable. PMID:9925535 TEM-15 is an extended-spectrum beta-lactamase that has been found in Haemophilus parainfluenzae. TEM-15 antibiotic_resistance ARO:3000886 TEM-15 ARO:3000886 TEM-15 is an extended-spectrum beta-lactamase that has been found in Haemophilus parainfluenzae. PMID:10681352 PMID:9925535 TEM-15 TEM-16 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. CAZ-7 TEM-16 antibiotic_resistance ARO:3000887 TEM-16 ARO:3000887 TEM-16 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:1416873 PMID:3055178 TEM-16 TEM-17 is an extended-spectrum beta-lactamase found in Capnocytophaga ochracea. TEM-17 antibiotic_resistance ARO:3000888 TEM-17 ARO:3000888 TEM-17 is an extended-spectrum beta-lactamase found in Capnocytophaga ochracea. PMID:10681352 TEM-17 The beta-lactamase name TEM-18 has been depreciated. antibiotic_resistance ARO:3000889 TEM-18 ARO:3000889 TEM-19 is an extended-spectrum beta-lactamase that has been found in clinical isolates. TEM-19 antibiotic_resistance ARO:3000890 TEM-19 ARO:3000890 TEM-19 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:2073111 TEM-19 TEM-20 is an extended-spectrum beta-lactamase found in several species of Gram-negative bacteria. TEM-20 antibiotic_resistance ARO:3000891 TEM-20 ARO:3000891 TEM-20 is an extended-spectrum beta-lactamase found in several species of Gram-negative bacteria. PMID:10103213 PMID:2184088 PMID:8586268 TEM-20 TEM-21 is an extended-spectrum beta-lactamase found in many species of Gram-negative bacteria. TEM-21 antibiotic_resistance ARO:3000892 TEM-21 ARO:3000892 TEM-21 is an extended-spectrum beta-lactamase found in many species of Gram-negative bacteria. PMID:10103213 PMID:2184088 PMID:8586268 PMID:9687421 TEM-21 TEM-22 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-22 antibiotic_resistance ARO:3000893 TEM-22 ARO:3000893 TEM-22 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:10103213 PMID:8239625 TEM-22 TEM-24 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. CAZ-6 TEM-24 antibiotic_resistance ARO:3000894 TEM-24 ARO:3000894 TEM-24 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:1416873 PMID:2558614 PMID:9925535 TEM-24 TEM-25 is an extended-spectrum beta-lactamase that has been found in clinical isolates. Sequence data unavailable. CTX-2 antibiotic_resistance ARO:3000895 TEM-25 ARO:3000895 TEM-25 is an extended-spectrum beta-lactamase that has been found in clinical isolates. Sequence data unavailable. PMID:1929316 PMID:7840586 TEM-26 is an extended-spectrum beta-lactamase that has been found in clinical isolates. TEM-26 YOU-1 antibiotic_resistance ARO:3000896 TEM-26 ARO:3000896 TEM-26 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:1416892 TEM-26 TEM-27 is an extended-spectrum beta-lactamase that has been found in clinical isolates. Sequence data unavailable. antibiotic_resistance ARO:3000897 TEM-27 ARO:3000897 TEM-27 is an extended-spectrum beta-lactamase that has been found in clinical isolates. Sequence data unavailable. PMID:7726515 TEM-28 is an extended-spectrum beta-lactamase found in E. coli. TEM-28 antibiotic_resistance ARO:3000898 TEM-28 ARO:3000898 TEM-28 is an extended-spectrum beta-lactamase found in E. coli. PMID:8787920 TEM-28 TEM-29 is an extended-spectrum beta-lactamase that has been found in clinical isolates. TEM-29 antibiotic_resistance ARO:3000899 TEM-29 ARO:3000899 TEM-29 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:8586268 TEM-29 TEM-30 is an inhibitor-resistant beta-lactamase found in E. coli. Confers resistance to amoxycilllin-clavulanic acid, ticarcillin-clavulanic acid, kanamycin, neomycin, and intermediate resistance to mezlocillin and piperacillin. E-GUER IRT-2 TEM-30 TRI-2 antibiotic_resistance ARO:3000900 TEM-30 ARO:3000900 TEM-30 is an inhibitor-resistant beta-lactamase found in E. coli. Confers resistance to amoxycilllin-clavulanic acid, ticarcillin-clavulanic acid, kanamycin, neomycin, and intermediate resistance to mezlocillin and piperacillin. PMID:1490918 PMID:33416461 PMID:8056297 TEM-30 TEM-31 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. E-SAL IRT-1 TEM-31 TRI-1 antibiotic_resistance ARO:3000901 TEM-31 ARO:3000901 TEM-31 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:1490918 PMID:8056297 TEM-31 TEM-32 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. IRT-3 TEM-32 antibiotic_resistance ARO:3000902 TEM-32 ARO:3000902 TEM-32 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:8257123 TEM-32 TEM-33 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. IRT-5 TEM-33 antibiotic_resistance ARO:3000903 TEM-33 ARO:3000903 TEM-33 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:8067742 PMID:9925535 TEM-33 TEM-34 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. IRT-6 TEM-34 TEM-97 antibiotic_resistance ARO:3000904 TEM-34 ARO:3000904 TEM-34 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:8067742 TEM-34 TEM-35 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. IRT-4 TEM-35 antibiotic_resistance ARO:3000905 TEM-35 ARO:3000905 TEM-35 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:25779568 PMID:8067742 TEM-35 TEM-36 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. IRT-7 TEM-36 antibiotic_resistance ARO:3000906 TEM-36 ARO:3000906 TEM-36 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:28369408 PMID:8067742 TEM-36 TEM-37 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. IRT-8 TEM-37 antibiotic_resistance ARO:3000907 TEM-37 ARO:3000907 TEM-37 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:26809117 PMID:7726509 TEM-37 TEM-38 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. Sequence data unavailable. IRT-9 antibiotic_resistance ARO:3000908 TEM-38 ARO:3000908 TEM-38 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. Sequence data unavailable. PMID:7726509 TEM-39 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. IRT-10 TEM-39 antibiotic_resistance ARO:3000909 TEM-39 ARO:3000909 TEM-39 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:7726509 TEM-39 TEM-40 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. IRT-11 IRT-167 TEM-40 antibiotic_resistance ARO:3000910 TEM-40 ARO:3000910 TEM-40 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:8585729 TEM-40 TEM-42 is an extended-spectrum beta-lactamase that has been found in clinical isolates. TEM-42 antibiotic_resistance ARO:3000911 TEM-42 ARO:3000911 TEM-42 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:8913451 TEM-42 TEM-43 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-43 antibiotic_resistance ARO:3000912 TEM-43 ARO:3000912 TEM-43 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:9661002 TEM-43 TEM-44 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. Sequence data unavailable. IRT2-2 IT-13 antibiotic_resistance ARO:3000913 TEM-44 ARO:3000913 TEM-44 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. Sequence data unavailable. PMID:8877532 TEM-45 is an inhibitor-resistant beta-lactamase found in E. coli. IRT-14 TEM-45 antibiotic_resistance ARO:3000914 TEM-45 ARO:3000914 TEM-45 is an inhibitor-resistant beta-lactamase found in E. coli. PMID:9021194 TEM-45 TEM-46 is an extended-spectrum beta-lactamase that has been found in clinical isolates. Sequence data unavailable. CAZ-9 antibiotic_resistance ARO:3000915 TEM-46 ARO:3000915 TEM-46 is an extended-spectrum beta-lactamase that has been found in clinical isolates. Sequence data unavailable. PMID:9056022 TEM-47 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-47 antibiotic_resistance ARO:3000916 TEM-47 ARO:3000916 TEM-47 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:9517925 TEM-47 TEM-48 is an extended-spectrum beta-lactamase found Klebsiella pneumoniae. TEM-48 antibiotic_resistance ARO:3000917 TEM-48 ARO:3000917 TEM-48 is an extended-spectrum beta-lactamase found Klebsiella pneumoniae. PMID:9517925 TEM-48 TEM-49 extended-spectrum beta-lactamase found in E. coli. TEM-49 antibiotic_resistance ARO:3000918 TEM-49 ARO:3000918 TEM-49 extended-spectrum beta-lactamase found in E. coli. PMID:9517925 TEM-49 TEM-50 is an inhibitor-resistant, extended-spectrum beta-lactamase that has been found in clinical isolates. Sequence data unavailable. CMT-1 antibiotic_resistance ARO:3000919 TEM-50 ARO:3000919 TEM-50 is an inhibitor-resistant, extended-spectrum beta-lactamase that has been found in clinical isolates. Sequence data unavailable. PMID:9174192 TEM-51 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. Sequence data unavailable. IRT-15 antibiotic_resistance ARO:3000920 TEM-51 ARO:3000920 TEM-51 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. Sequence data unavailable. PMID:9371365 TEM-52 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae and Salmonella enterica. TEM-52 antibiotic_resistance ARO:3000921 TEM-52 ARO:3000921 TEM-52 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae and Salmonella enterica. PMID:9449269 TEM-52 TEM-53 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-53 antibiotic_resistance ARO:3000922 TEM-53 ARO:3000922 TEM-53 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:9925535 TEM-53 TEM-54 is an inhibitor-resistant beta-lactamase found in E. coli. TEM-54 antibiotic_resistance ARO:3000923 TEM-54 ARO:3000923 TEM-54 is an inhibitor-resistant beta-lactamase found in E. coli. PMID:9925535 TEM-54 TEM-55 is a broad-spectrum beta-lactamase found in E. coli. TEM-55 antibiotic_resistance ARO:3000924 TEM-55 ARO:3000924 TEM-55 TEM-56 is an extended-spectrum beta-lactamase that has been found in clinical isolates. Sequence data unavailable. antibiotic_resistance ARO:3000925 TEM-56 ARO:3000925 TEM-56 is an extended-spectrum beta-lactamase that has been found in clinical isolates. Sequence data unavailable. PMID:10639384 TEM-57 is a broad-spectrum beta-lactamase found in E. coli. TEM-57 antibiotic_resistance ARO:3000926 TEM-57 ARO:3000926 TEM-57 is a broad-spectrum beta-lactamase found in E. coli. PMID:10543745 TEM-57 TEM-58 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. Sequence data unavailable. antibiotic_resistance ARO:3000927 TEM-58 ARO:3000927 TEM-58 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. Sequence data unavailable. PMID:9559800 TEM-59 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. IRT-17 TEM-59 antibiotic_resistance ARO:3000928 TEM-59 ARO:3000928 TEM-59 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:10390218 TEM-59 TEM-60 is an extended-spectrum beta-lactamase that has been found in clinical isolates. TEM-60 antibiotic_resistance ARO:3000929 TEM-60 ARO:3000929 TEM-60 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:9624494 TEM-60 TEM-61 is an extended-spectrum beta-lactamase that has been found in clinical isolates. CAZ-hi TEM-61 antibiotic_resistance ARO:3000930 TEM-61 ARO:3000930 TEM-61 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:2665644 TEM-61 TEM-63 is an extended-spectrum beta-lactamase found in E. coli. TEM-63 TEM-64 antibiotic_resistance ARO:3000931 TEM-63 ARO:3000931 TEM-63 is an extended-spectrum beta-lactamase found in E. coli. PMID:11120950 TEM-63 TEM-65 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. Sequence data unavailable. IRT-16 antibiotic_resistance ARO:3000932 TEM-65 ARO:3000932 TEM-65 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. Sequence data unavailable. PMID:10543745 TEM-66 is an extended-spectrum beta-lactamase that has been found in clinical isolates. Sequence data unavailable. antibiotic_resistance ARO:3000933 TEM-66 ARO:3000933 TEM-66 is an extended-spectrum beta-lactamase that has been found in clinical isolates. Sequence data unavailable. PMID:10543745 TEM-67 is an inhibitor-resistant beta-lactamase found in Proteus mirabilis. TEM-67 antibiotic_resistance ARO:3000934 TEM-67 ARO:3000934 TEM-67 is an inhibitor-resistant beta-lactamase found in Proteus mirabilis. PMID:12499163 TEM-67 TEM-68 is an inhibitor resistant, extended-spectrum beta-lactamase found in Klebsiella pneumoniae. CMT-2 TEM-68 antibiotic_resistance ARO:3000935 TEM-68 ARO:3000935 TEM-68 is an inhibitor resistant, extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:10817699 PMID:12019125 TEM-68 TEM-70 is a beta-lactamase found in E. coli. TEM-70 antibiotic_resistance ARO:3000936 TEM-70 ARO:3000936 TEM-70 is a beta-lactamase found in E. coli. PMID:23643553 TEM-70 TEM-71 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-71 antibiotic_resistance ARO:3000937 TEM-71 ARO:3000937 TEM-71 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:12019125 TEM-71 TEM-72 is an extended-spectrum beta-lactamase found in Proteus mirabilis and Morganella morganii. TEM-72 antibiotic_resistance ARO:3000938 TEM-72 ARO:3000938 TEM-72 is an extended-spectrum beta-lactamase found in Proteus mirabilis and Morganella morganii. PMID:10952610 TEM-72 TEM-73 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. IRT-18 TEM-73 antibiotic_resistance ARO:3000939 TEM-73 ARO:3000939 TEM-73 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:10543745 TEM-73 TEM-74 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. Sequence data unavailable. IRT-19 antibiotic_resistance ARO:3000940 TEM-74 ARO:3000940 TEM-74 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. Sequence data unavailable. PMID:10543745 TEM-75 is an extended-spectrum beta-lactamase that has been found in clinical isolates. TEM-75 antibiotic_resistance ARO:3000941 TEM-75 ARO:3000941 TEM-75 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:10624595 TEM-75 TEM-76 is an inhibitor-resistant beta-lactamase found in E. coli. IRT-20 TEM-76 antibiotic_resistance ARO:3000942 TEM-76 ARO:3000942 TEM-76 is an inhibitor-resistant beta-lactamase found in E. coli. PMID:10991849 TEM-76 TEM-78 is an inhibitor-resistant beta-lactamase found in E. coli. IRT-22 TEM-78 antibiotic_resistance ARO:3000944 TEM-78 ARO:3000944 TEM-78 is an inhibitor-resistant beta-lactamase found in E. coli. PMID:10991849 TEM-78 TEM-79 is an inhibitor-resistant beta-lactamase found in E. coli. TEM-79 antibiotic_resistance ARO:3000946 TEM-79 ARO:3000946 TEM-79 is an inhibitor-resistant beta-lactamase found in E. coli. PMID:10991849 TEM-79 TEM-80 is an inhibitor-resistant beta-lactamase found in Enterobacter cloacae. IRT-24 TEM-80 antibiotic_resistance ARO:3000947 TEM-80 ARO:3000947 TEM-80 is an inhibitor-resistant beta-lactamase found in Enterobacter cloacae. PMID:11959543 TEM-80 TEM-81 is an inhibitor-resistant beta-lactamase found in E. coli. TEM-81 antibiotic_resistance ARO:3000948 TEM-81 ARO:3000948 TEM-81 is an inhibitor-resistant beta-lactamase found in E. coli. PMID:10991849 TEM-81 TEM-82 is an inhibitor-resistant beta-lactamase found in E. coli. TEM-82 antibiotic_resistance ARO:3000949 TEM-82 ARO:3000949 TEM-82 is an inhibitor-resistant beta-lactamase found in E. coli. PMID:10991849 TEM-82 TEM-83 is an inhibitor-resistant beta-lactamase found in E. coli. TEM-83 antibiotic_resistance ARO:3000950 TEM-83 ARO:3000950 TEM-83 is an inhibitor-resistant beta-lactamase found in E. coli. PMID:10991849 TEM-83 TEM-84 is an inhibitor-resistant beta-lactamase found in E. coli. TEM-84 antibiotic_resistance ARO:3000951 TEM-84 ARO:3000951 TEM-84 is an inhibitor-resistant beta-lactamase found in E. coli. PMID:10991849 TEM-84 TEM-85 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-85 antibiotic_resistance ARO:3000952 TEM-85 ARO:3000952 TEM-85 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:15855509 TEM-85 TEM-86 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-86 antibiotic_resistance ARO:3000953 TEM-86 ARO:3000953 TEM-86 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:15855509 TEM-86 TEM-87 is an extended-spectrum beta-lactamase found in Proteus mirabilis. TEM-87 antibiotic_resistance ARO:3000954 TEM-87 ARO:3000954 TEM-87 is an extended-spectrum beta-lactamase found in Proteus mirabilis. PMID:11850290 TEM-87 TEM-88 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-88 antibiotic_resistance ARO:3000955 TEM-88 ARO:3000955 TEM-88 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:11709362 TEM-88 TEM-89 is an inhibitor-resistant, extended-spectrum beta-lactamase that has been found in clinical isolates. CMT-3 TEM-89 antibiotic_resistance ARO:3000956 TEM-89 ARO:3000956 TEM-89 is an inhibitor-resistant, extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:11709345 TEM-89 TEM-90 is a broad-spectrum beta-lactamase found in E. coli. TEM-90 TLE-1 antibiotic_resistance ARO:3000957 TEM-90 ARO:3000957 TEM-90 is a broad-spectrum beta-lactamase found in E. coli. PMID:11557499 TEM-90 TEM-91 is an extended-spectrum beta-lactamase found in E. coli. TEM-91 antibiotic_resistance ARO:3000958 TEM-91 ARO:3000958 TEM-91 is an extended-spectrum beta-lactamase found in E. coli. PMID:12937007 TEM-91 TEM-92 is an extended-spectrum beta-lactamase found in Proteus mirabilis. TEM-92 antibiotic_resistance ARO:3000959 TEM-92 ARO:3000959 TEM-92 is an extended-spectrum beta-lactamase found in Proteus mirabilis. PMID:11257046 TEM-92 TEM-93 is an extended-spectrum beta-lactamase found in E. coli. TEM-93 antibiotic_resistance ARO:3000960 TEM-93 ARO:3000960 TEM-93 is an extended-spectrum beta-lactamase found in E. coli. PMID:15855509 TEM-93 TEM-94 is an extended-spectrum beta-lactamase found in E. coli. TEM-94 antibiotic_resistance ARO:3000961 TEM-94 ARO:3000961 TEM-94 is an extended-spectrum beta-lactamase found in E. coli. PMID:15855509 TEM-94 TEM-95 is a broad-spectrum beta-lactamase found in E. coli. TEM-95 antibiotic_resistance ARO:3000962 TEM-95 ARO:3000962 TEM-95 is a broad-spectrum beta-lactamase found in E. coli. PMID:12234838 TEM-95 TEM-96 is a beta-lactamase found in E. coli. TEM-96 antibiotic_resistance ARO:3000963 TEM-96 ARO:3000963 TEM-96 is a beta-lactamase found in E. coli. PMID:24499167 TEM-96 TEM-101 is an extended-spectrum beta-lactamase found in E. coli. TEM-101 antibiotic_resistance ARO:3000964 TEM-101 ARO:3000964 TEM-101 is an extended-spectrum beta-lactamase found in E. coli. PMID:3055178 TEM-101 TEM-102 is an extended-spectrum beta-lactamase that has been found in clinical isolates. TEM-102 antibiotic_resistance ARO:3000965 TEM-102 ARO:3000965 TEM-102 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:12878521 TEM-102 TEM-103 is an inhibitor-resistant beta-lactamase that has been found in E. coli. IRT-28 TEM-103 antibiotic_resistance ARO:3000966 TEM-103 ARO:3000966 TEM-103 is an inhibitor-resistant beta-lactamase that has been found in E. coli. PMID:12384377 TEM-103 TEM-104 is a beta-lactamase found in Klebsiella pneumoniae. TEM-104 antibiotic_resistance ARO:3000967 TEM-104 ARO:3000967 TEM-104 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16533535 PMID:27598630 TEM-104 TEM-105 is a beta-lactamase found in E. coli. TEM-105 antibiotic_resistance ARO:3000968 TEM-105 ARO:3000968 TEM-105 is a beta-lactamase found in E. coli. PMID:16533535 TEM-105 TEM-106 is an extended-spectrum beta-lactamase found in E. coli. TEM-106 antibiotic_resistance ARO:3000969 TEM-106 ARO:3000969 TEM-106 is an extended-spectrum beta-lactamase found in E. coli. PMID:11959586 TEM-106 TEM-107 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-107 antibiotic_resistance ARO:3000970 TEM-107 ARO:3000970 TEM-107 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:11959586 TEM-107 TEM-108 is a beta-lactamase that has been found in clinical isolates. TEM-108 antibiotic_resistance ARO:3000971 TEM-108 ARO:3000971 TEM-108 is a beta-lactamase that has been found in clinical isolates. PMID:15297528 TEM-108 TEM-109 is an inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli. CMT-5 TEM-109 antibiotic_resistance ARO:3000972 TEM-109 ARO:3000972 TEM-109 is an inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli. PMID:16251281 TEM-109 TEM-110 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-110 antibiotic_resistance ARO:3000973 TEM-110 ARO:3000973 TEM-110 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:18292096 TEM-110 TEM-111 is a beta-lactamase found in E. coli and P. mirabilis. TEM-111 antibiotic_resistance ARO:3000974 TEM-111 ARO:3000974 TEM-111 is a beta-lactamase found in E. coli and P. mirabilis. PMID:22450979 TEM-111 TEM-112 is an extended-spectrum beta-lactamase found in E. coli. TEM-112 antibiotic_resistance ARO:3000975 TEM-112 ARO:3000975 TEM-112 is an extended-spectrum beta-lactamase found in E. coli. PMID:15282240 TEM-112 TEM-113 is an extended-spectrum beta-lactamase found in Proteus mirabilis. TEM-113 antibiotic_resistance ARO:3000976 TEM-113 ARO:3000976 TEM-113 is an extended-spectrum beta-lactamase found in Proteus mirabilis. PMID:15282240 TEM-113 TEM-114 is an extended-spectrum beta-lactamase found in Klebsiella aerogenes. TEM-114 antibiotic_resistance ARO:3000977 TEM-114 ARO:3000977 TEM-114 is an extended-spectrum beta-lactamase found in Klebsiella aerogenes. PMID:15282240 TEM-114 TEM-115 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-115 antibiotic_resistance ARO:3000978 TEM-115 ARO:3000978 TEM-115 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:15047521 TEM-115 TEM-116 is a broad-spectrum beta-lactamase found in many species of bacteria. TEM-116 antibiotic_resistance ARO:3000979 TEM-116 ARO:3000979 TEM-116 is a broad-spectrum beta-lactamase found in many species of bacteria. PMID:15243036 TEM-116 TEM-117 is a beta-lactamase that has been found in clinical isolates. TEM-117 antibiotic_resistance ARO:3000980 TEM-117 ARO:3000980 TEM-117 TEM-118 is an extended-spectrum beta-lactamase that has been found in clinical isolates. TEM-118 TEM-HM antibiotic_resistance ARO:3000981 TEM-118 ARO:3000981 TEM-118 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:12354869 TEM-118 TEM-120 is an extended-spectrum beta-lactamase found in Klebsiella oxytoca. TEM-120 antibiotic_resistance ARO:3000982 TEM-120 ARO:3000982 TEM-120 is an extended-spectrum beta-lactamase found in Klebsiella oxytoca. PMID:15047521 TEM-120 TEM-121 is an inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli and Klebsiella aerogenes. CMT-4 TEM-121 antibiotic_resistance ARO:3000983 TEM-121 ARO:3000983 TEM-121 is an inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli and Klebsiella aerogenes. PMID:15561821 TEM-121 TEM-122 is an inhibitor-resistant beta-lactamase found in E. coli. TEM-122 antibiotic_resistance ARO:3000984 TEM-122 ARO:3000984 TEM-122 is an inhibitor-resistant beta-lactamase found in E. coli. PMID:15105100 TEM-122 TEM-123 is an extended-spectrum beta-lactamase found in Proteus mirabilis. TEM-123 antibiotic_resistance ARO:3000985 TEM-123 ARO:3000985 TEM-123 TEM-124 is an extended-spectrum beta-lactamase found in Morganella morganii. TEM-124 antibiotic_resistance ARO:3000986 TEM-124 ARO:3000986 TEM-124 TEM-125 is a CMT-type, inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli. TEM-125 antibiotic_resistance ARO:3000987 TEM-125 ARO:3000987 TEM-125 is a CMT-type, inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli. PMID:16801418 TEM-125 TEM-126 is an extended-spectrum beta-lactamase found in E. coli. TEM-126 antibiotic_resistance ARO:3000988 TEM-126 ARO:3000988 TEM-126 is an extended-spectrum beta-lactamase found in E. coli. PMID:15282240 TEM-126 TEM-127 is a broad-spectrum beta-lactamase found in E. coli. TEM-127 antibiotic_resistance ARO:3000989 TEM-127 ARO:3000989 TEM-127 is a broad-spectrum beta-lactamase found in E. coli. PMID:15650379 TEM-127 TEM-128 is a broad-spectrum beta-lactamase found in E. coli. TEM-128 antibiotic_resistance ARO:3000990 TEM-128 ARO:3000990 TEM-128 is a broad-spectrum beta-lactamase found in E. coli. PMID:15650379 TEM-128 TEM-129 is an extended-spectrum beta-lactamase found in Klebsiella oxytoca. TEM-129 antibiotic_resistance ARO:3000993 TEM-129 ARO:3000993 TEM-129 is an extended-spectrum beta-lactamase found in Klebsiella oxytoca. PMID:15472005 TEM-129 TEM-130 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-130 antibiotic_resistance ARO:3000994 TEM-130 ARO:3000994 TEM-130 TEM-131 is an extended-spectrum beta-lactamase found in Salmonella enterica. TEM-131 antibiotic_resistance ARO:3000995 TEM-131 ARO:3000995 TEM-131 is an extended-spectrum beta-lactamase found in Salmonella enterica. PMID:15504851 TEM-131 TEM-132 is an extended-spectrum beta-lactamase found in E. coli and Klebsiella pneumoniae. TEM-132 antibiotic_resistance ARO:3000996 TEM-132 ARO:3000996 TEM-132 is an extended-spectrum beta-lactamase found in E. coli and Klebsiella pneumoniae. PMID:15980402 TEM-132 TEM-133 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-133 antibiotic_resistance ARO:3000997 TEM-133 ARO:3000997 TEM-133 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:15855544 TEM-133 TEM-134 is an extended-spectrum beta-lactamase found in Citrobacter koseri. TEM-134 antibiotic_resistance ARO:3000998 TEM-134 ARO:3000998 TEM-134 is an extended-spectrum beta-lactamase found in Citrobacter koseri. PMID:15793140 TEM-134 TEM-135 is a broad-spectrum beta-lactamase found in Salmonella enterica. TEM-135 antibiotic_resistance ARO:3000999 TEM-135 ARO:3000999 TEM-135 is a broad-spectrum beta-lactamase found in Salmonella enterica. PMID:15731203 PMID:31202926 TEM-135 TEM-136 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-136 antibiotic_resistance ARO:3001000 TEM-136 ARO:3001000 TEM-136 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:16531430 TEM-136 TEM-137 is an extended-spectrum beta-lactamase found in Shigella sonnei. TEM-137 antibiotic_resistance ARO:3001001 TEM-137 ARO:3001001 TEM-137 is an extended-spectrum beta-lactamase found in Shigella sonnei. PMID:17561568 TEM-137 TEM-138 is an extended-spectrum beta-lactamase found in Salmonella enterica. TEM-138 antibiotic_resistance ARO:3001002 TEM-138 ARO:3001002 TEM-138 is an extended-spectrum beta-lactamase found in Salmonella enterica. PMID:16940125 TEM-138 TEM-139 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-139 antibiotic_resistance ARO:3001003 TEM-139 ARO:3001003 TEM-139 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:17382521 TEM-139 TEM-141 is a broad-spectrum beta-lactamase found in Enterobacter cloacae. TEM-141 antibiotic_resistance ARO:3001004 TEM-141 ARO:3001004 TEM-141 is a broad-spectrum beta-lactamase found in Enterobacter cloacae. PMID:17881870 TEM-141 TEM-142 is an beta-lactamase found in E. coli. TEM-142 antibiotic_resistance ARO:3001005 TEM-142 ARO:3001005 TEM-142 TEM-143 is an extended-spectrum beta-lactamase found in E. coli. TEM-143 antibiotic_resistance ARO:3001006 TEM-143 ARO:3001006 TEM-143 TEM-144 is an extended-spectrum beta-lactamase found in Salmonella enterica. TEM-144 antibiotic_resistance ARO:3001007 TEM-144 ARO:3001007 TEM-144 is an extended-spectrum beta-lactamase found in Salmonella enterica. PMID:16436745 TEM-144 TEM-145 is an inhibitor-resistant beta-lactamase found in E. coli. TEM-145 antibiotic_resistance ARO:3001012 TEM-145 ARO:3001012 TEM-145 TEM-146 is a beta-lactamase found in E. coli. TEM-146 antibiotic_resistance ARO:3001013 TEM-146 ARO:3001013 TEM-146 TEM-147 is an extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. TEM-147 antibiotic_resistance ARO:3001014 TEM-147 ARO:3001014 TEM-147 TEM-148 is a TEM beta-lactamase. TEM-148 antibiotic_resistance ARO:3001015 TEM-148 ARO:3001015 TEM-148 TEM-149 is an extended-spectrum beta-lactamase found in Klebsiella aerogenes. TEM-149 antibiotic_resistance ARO:3001016 TEM-149 ARO:3001016 TEM-149 is an extended-spectrum beta-lactamase found in Klebsiella aerogenes. PMID:18160520 TEM-149 TEM-150 is a beta-lactamase found in Enterobacter spp., E. coli, and Klebsiella pneumoniae. TEM-150 antibiotic_resistance ARO:3001017 TEM-150 ARO:3001017 TEM-150 TEM-151 is a CMT-type, inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli. TEM-151 antibiotic_resistance ARO:3001018 TEM-151 ARO:3001018 TEM-151 is a CMT-type, inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli. PMID:17220412 TEM-151 TEM-152 is a CMT-type, inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli. TEM-152 antibiotic_resistance ARO:3001019 TEM-152 ARO:3001019 TEM-152 is a CMT-type, inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli. PMID:17220412 TEM-152 TEM-154 is a CMT-type, inhibitor-resistant, extended-spectrum beta-lactamase. TEM-154 antibiotic_resistance ARO:3001020 TEM-154 ARO:3001020 TEM-154 is a CMT-type, inhibitor-resistant, extended-spectrum beta-lactamase. PMID:17913717 TEM-154 TEM-155 is an extended-spectrum beta-lactamase. TEM-155 antibiotic_resistance ARO:3001021 TEM-155 ARO:3001021 TEM-155 is an extended-spectrum beta-lactamase. PMID:19075050 TEM-155 TEM-156 is a TEM beta-lactamase. TEM-156 antibiotic_resistance ARO:3001022 TEM-156 ARO:3001022 TEM-156 TEM-157 is an extended-spectrum beta-lactamase found in Enterobacter cloacae. TEM-157 antibiotic_resistance ARO:3001023 TEM-157 ARO:3001023 TEM-157 is an extended-spectrum beta-lactamase found in Enterobacter cloacae. PMID:18653970 TEM-157 TEM-158 is an inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli. CMT-9 TEM-158 antibiotic_resistance ARO:3001024 TEM-158 ARO:3001024 TEM-158 is an inhibitor-resistant, extended-spectrum beta-lactamase found in E. coli. PMID:17709463 TEM-158 TEM-159 is an inhibitor-resistant beta-lactamase found in Proteus mirabilis. TEM-159 antibiotic_resistance ARO:3001025 TEM-159 ARO:3001025 TEM-159 is an inhibitor-resistant beta-lactamase found in Proteus mirabilis. PMID:18292096 TEM-159 TEM-160 is an inhibitor-resistant beta-lactamase found in Proteus mirabilis. TEM-160 antibiotic_resistance ARO:3001026 TEM-160 ARO:3001026 TEM-160 is an inhibitor-resistant beta-lactamase found in Proteus mirabilis. PMID:18292096 TEM-160 The beta-lactamase name TEM-161 has been depreciated. antibiotic_resistance ARO:3001027 TEM-161 ARO:3001027 TEM-162 is a beta-lactamase found in Acinetobacter haemolyticus. TEM-162 antibiotic_resistance ARO:3001028 TEM-162 ARO:3001028 TEM-162 TEM-163 is an inhibitor resistant beta-lactamase found in E. coli. TEM-163 antibiotic_resistance ARO:3001029 TEM-163 ARO:3001029 TEM-163 TEM-164 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. TEM-164 antibiotic_resistance ARO:3001030 TEM-164 ARO:3001030 TEM-164 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19728777 TEM-164 TEM-165 is a beta-lactamase that has been found in clinical isolates. Sequence data unavailable. antibiotic_resistance ARO:3001031 TEM-165 ARO:3001031 TEM-165 is a beta-lactamase that has been found in clinical isolates. Sequence data unavailable. PMID:21860889 TEM-166 is a beta-lactamase found in E. coli. TEM-166 antibiotic_resistance ARO:3001032 TEM-166 ARO:3001032 TEM-166 TEM-167 is an extended-spectrum beta-lactamase found in E. coli. TEM-167 antibiotic_resistance ARO:3001033 TEM-167 ARO:3001033 TEM-167 TEM-168 is an extended-spectrum beta-lactamase. TEM-168 antibiotic_resistance ARO:3001034 TEM-168 ARO:3001034 TEM-168 is an extended-spectrum beta-lactamase. PMID:19687235 TEM-168 TEM-169 is an extended spectrum beta-lactamase. TEM-169 antibiotic_resistance ARO:3001035 TEM-169 ARO:3001035 TEM-169 is an extended spectrum beta-lactamase. PMID:19785534 TEM-169 TEM-170 is a beta-lactamase. Sequence data unavailable. antibiotic_resistance ARO:3001036 TEM-170 ARO:3001036 TEM-170 is a beta-lactamase. Sequence data unavailable. PMID:21903826 TEM-171 is a beta-lactamase. TEM-171 antibiotic_resistance ARO:3001037 TEM-171 ARO:3001037 TEM-171 is a beta-lactamase. PMID:21903826 TEM-171 TEM-172 is a beta-lactamase. Sequence data unavailable. antibiotic_resistance ARO:3001038 TEM-172 ARO:3001038 TEM-172 is a beta-lactamase. Sequence data unavailable. PMID:21903826 TEM-173 is a beta-lactamase. Sequence data unavailable. antibiotic_resistance ARO:3001039 TEM-173 ARO:3001039 TEM-173 is a beta-lactamase. Sequence data unavailable. PMID:21903826 TEM-174 is a beta-lactamase. Sequence data unavailable. antibiotic_resistance ARO:3001040 TEM-174 ARO:3001040 TEM-174 is a beta-lactamase. Sequence data unavailable. PMID:21903826 TEM-176 is a beta-lactamase. TEM-176 antibiotic_resistance ARO:3001041 TEM-176 ARO:3001041 TEM-176 is a beta-lactamase. PMID:23643553 TEM-176 TEM-177 is an extended-spectrum beta-lactamase. TEM-177 antibiotic_resistance ARO:3001042 TEM-177 ARO:3001042 TEM-177 is an extended-spectrum beta-lactamase. PMID:23210906 TEM-177 TEM-178 is an inhibitor-resistant, extended-spectrum beta-lactamase. TEM-178 antibiotic_resistance ARO:3001043 TEM-178 ARO:3001043 TEM-178 is an inhibitor-resistant, extended-spectrum beta-lactamase. PMID:9371336 TEM-178 TEM-181 is a beta-lactamase. TEM-181 antibiotic_resistance ARO:3001044 TEM-181 ARO:3001044 TEM-181 is a beta-lactamase. PMID:21947397 TEM-181 TEM-183 is a broad-spectrum beta-lactamase. TEM-183 antibiotic_resistance ARO:3001045 TEM-183 ARO:3001045 TEM-183 TEM-186 is a beta-lactamase. TEM-186 antibiotic_resistance ARO:3001046 TEM-186 ARO:3001046 TEM-186 is a beta-lactamase. PMID:22397509 TEM-186 TEM-187 is an extended-spectrum beta-lactamase found in P. mirabilis. TEM-187 antibiotic_resistance ARO:3001047 TEM-187 ARO:3001047 TEM-187 is an extended-spectrum beta-lactamase found in P. mirabilis. PMID:23478954 TEM-187 TEM-188 is an extended-spectrum beta-lactamase. TEM-188 antibiotic_resistance ARO:3001048 TEM-188 ARO:3001048 TEM-188 is an extended-spectrum beta-lactamase. PMID:22871227 TEM-188 TEM-189 is a beta-lactamase. TEM-189 antibiotic_resistance ARO:3001049 TEM-189 ARO:3001049 TEM-189 TEM-190 is a beta-lactamase. TEM-190 antibiotic_resistance ARO:3001050 TEM-190 ARO:3001050 TEM-190 TEM-191 is a beta-lactamase. TEM-191 antibiotic_resistance ARO:3001051 TEM-191 ARO:3001051 TEM-191 is a beta-lactamase. PMID:22718774 TEM-191 TEM-192 is a beta-lactamase. TEM-192 antibiotic_resistance ARO:3001052 TEM-192 ARO:3001052 TEM-192 is a beta-lactamase. PMID:22718774 TEM-192 TEM-193 is a beta-lactamase. TEM-193 antibiotic_resistance ARO:3001053 TEM-193 ARO:3001053 TEM-193 TEM-194 is a beta-lactamase. TEM-194 antibiotic_resistance ARO:3001054 TEM-194 ARO:3001054 TEM-194 TEM-195 is a beta-lactamase. TEM-195 antibiotic_resistance ARO:3001055 TEM-195 ARO:3001055 TEM-195 is a beta-lactamase. PMID:24499167 TEM-195 TEM-197 is an extended-spectrum beta-lactamase. TEM-197 antibiotic_resistance ARO:3001056 TEM-197 ARO:3001056 TEM-197 TEM-198 is a beta-lactamase. TEM-198 antibiotic_resistance ARO:3001057 TEM-198 ARO:3001057 TEM-198 TEM-199 is a beta-lactamase. TEM-199 antibiotic_resistance ARO:3001058 TEM-199 ARO:3001058 TEM-199 SHV-1 is a broad-spectrum beta-lactamase found in Klebsiella spp., as well as Acinetobacter spp., E. coli., Raoultella terrigena, and Yersinia pestis. PIT-2 SHV-1 antibiotic_resistance ARO:3001059 SHV-1 ARO:3001059 SHV-1 is a broad-spectrum beta-lactamase found in Klebsiella spp., as well as Acinetobacter spp., E. coli., Raoultella terrigena, and Yersinia pestis. PMID:10582889 PMID:378931 SHV-1 SHV-2 is an extended-spectrum beta-lactamase found in E. coli., Klebsiella pneumoniae, and Shigella flexneri. SHV-2 antibiotic_resistance ARO:3001060 SHV-2 ARO:3001060 SHV-2 is an extended-spectrum beta-lactamase found in E. coli., Klebsiella pneumoniae, and Shigella flexneri. PMID:10582889 PMID:2033379 SHV-2 SHV-2A is an extended-spectrum beta-lactamase found in Enterobacter cloacae, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Salmonella enterica. SHV-2A antibiotic_resistance ARO:3001061 SHV-2A ARO:3001061 SHV-2A is an extended-spectrum beta-lactamase found in Enterobacter cloacae, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Salmonella enterica. PMID:10223953 SHV-2A SHV-3 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-3 antibiotic_resistance ARO:3001062 SHV-3 ARO:3001062 SHV-3 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:2033379 PMID:2694951 SHV-3 SHV-4 is an extended-spectrum beta-lactamase that has been found in clinical isolates. CAZ-5 SHV-4 antibiotic_resistance ARO:3001063 SHV-4 ARO:3001063 SHV-4 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:2694955 SHV-4 SHV-5 is an extended-spectrum beta-lactamase found in Acinetobacter baumannii, Enterobacter cloacae, E. coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Salmonella enterica. CAZ-4 SHV-5 antibiotic_resistance ARO:3001064 SHV-5 ARO:3001064 SHV-5 is an extended-spectrum beta-lactamase found in Acinetobacter baumannii, Enterobacter cloacae, E. coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Salmonella enterica. PMID:2088203 SHV-5 SHV-6 is an extended-spectrum beta-lactamase that has been found in clinical isolates. SHV-6 antibiotic_resistance ARO:3001065 SHV-6 ARO:3001065 SHV-6 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:9228783 SHV-6 SHV-7 is an extended-spectrum beta-lactamase found in E. coli. SHV-7 antibiotic_resistance ARO:3001066 SHV-7 ARO:3001066 SHV-7 is an extended-spectrum beta-lactamase found in E. coli. PMID:7785992 SHV-7 SHV-8 is an extended-spectrum beta-lactamase found in E. coli. SHV-8 antibiotic_resistance ARO:3001067 SHV-8 ARO:3001067 SHV-8 is an extended-spectrum beta-lactamase found in E. coli. PMID:9056008 SHV-8 SHV-9 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-5a SHV-9 antibiotic_resistance ARO:3001068 SHV-9 ARO:3001068 SHV-9 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:8674992 PMID:9087500 SHV-9 SHV-10 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. Sequence data unavailable. antibiotic_resistance ARO:3001069 SHV-10 ARO:3001069 SHV-10 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. Sequence data unavailable. PMID:9087500 SHV-11 is a broad-spectrum beta-lactamase found in E. coli, Klebsiella pneumoniae, Proteus mirabilis, and Shigella dysenteriae. SHV-1-2a SHV-11 antibiotic_resistance ARO:3001070 SHV-11 ARO:3001070 SHV-11 is a broad-spectrum beta-lactamase found in E. coli, Klebsiella pneumoniae, Proteus mirabilis, and Shigella dysenteriae. PMID:9145849 SHV-11 SHV-12 is an extended-spectrum beta-lactamase found in Acinetobacter baumannii. SHV-12 SHV-5-2a antibiotic_resistance ARO:3001071 SHV-12 ARO:3001071 SHV-12 is an extended-spectrum beta-lactamase found in Acinetobacter baumannii. PMID:9145849 SHV-12 SHV-13 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-13 antibiotic_resistance ARO:3001072 SHV-13 ARO:3001072 SHV-13 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:10722518 SHV-13 SHV-14 is an broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-14 antibiotic_resistance ARO:3001073 SHV-14 ARO:3001073 SHV-14 is an broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:11120985 SHV-14 SHV-15 is an extended-spectrum beta-lactamase found in E. coli. SHV-15 antibiotic_resistance ARO:3001074 SHV-15 ARO:3001074 SHV-15 is an extended-spectrum beta-lactamase found in E. coli. PMID:10689171 SHV-15 SHV-16 is an extended-spectrum beta-lactamase that has been found in clinical isolates. It differs from SHV-1 by a 163DRWET167 insertion. SHV-16 antibiotic_resistance ARO:3001075 SHV-16 ARO:3001075 SHV-16 is an extended-spectrum beta-lactamase that has been found in clinical isolates. It differs from SHV-1 by a 163DRWET167 insertion. PMID:11502518 SHV-16 SHV-18 is an extended-spectrum beta-lactamase found in Acinetobacter baumannii and Klebsiella pneumoniae. SHV-18 antibiotic_resistance ARO:3001076 SHV-18 ARO:3001076 SHV-18 is an extended-spectrum beta-lactamase found in Acinetobacter baumannii and Klebsiella pneumoniae. PMID:10952583 SHV-18 SHV-19 is a broad-spectrum beta-lactamase that has been found in clinical isolates. SHV-19 antibiotic_resistance ARO:3001077 SHV-19 ARO:3001077 SHV-19 is a broad-spectrum beta-lactamase that has been found in clinical isolates. PMID:11120950 SHV-19 SHV-20 is a broad-spectrum beta-lactamase that has been found in clinical isolates. SHV-20 antibiotic_resistance ARO:3001078 SHV-20 ARO:3001078 SHV-20 is a broad-spectrum beta-lactamase that has been found in clinical isolates. PMID:11120950 SHV-20 SHV-21 is a broad-spectrum beta-lactamase that has been found in clinical isolates. SHV-21 antibiotic_resistance ARO:3001079 SHV-21 ARO:3001079 SHV-21 is a broad-spectrum beta-lactamase that has been found in clinical isolates. PMID:11120950 SHV-21 SHV-22 is a broad-spectrum beta-lactamase that has been found in clinical isolates. SHV-22 antibiotic_resistance ARO:3001080 SHV-22 ARO:3001080 SHV-22 is a broad-spectrum beta-lactamase that has been found in clinical isolates. PMID:11120950 SHV-22 SHV-23 is an extended-spectrum beta-lactamase that has been found in clinical isolates. SHV-23 antibiotic_resistance ARO:3001081 SHV-23 ARO:3001081 SHV-23 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:15081091 SHV-23 SHV-24 is an extended-spectrum beta-lactamase found in E. coli. SHV-24 antibiotic_resistance ARO:3001082 SHV-24 ARO:3001082 SHV-24 is an extended-spectrum beta-lactamase found in E. coli. PMID:10817740 SHV-24 SHV-25 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-25 antibiotic_resistance ARO:3001083 SHV-25 ARO:3001083 SHV-25 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:11502506 SHV-25 SHV-26 is an inhibitor-resistant beta-lactamase found in Klebsiella pneumoniae. SHV-26 antibiotic_resistance ARO:3001084 SHV-26 ARO:3001084 SHV-26 is an inhibitor-resistant beta-lactamase found in Klebsiella pneumoniae. PMID:11502506 SHV-26 SHV-27 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-27 antibiotic_resistance ARO:3001085 SHV-27 ARO:3001085 SHV-27 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:11266422 SHV-27 SHV-28 is a beta-lactamase found in Klebsiella pneumoniae. SHV-28 antibiotic_resistance ARO:3001086 SHV-28 ARO:3001086 SHV-28 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19172061 SHV-28 SHV-29 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-29 antibiotic_resistance ARO:3001087 SHV-29 ARO:3001087 SHV-29 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:11257029 SHV-29 SHV-30 is an extended-spectrum beta-lactamase found in Enterobacter cloacae. SHV-30 antibiotic_resistance ARO:3001088 SHV-30 ARO:3001088 SHV-30 is an extended-spectrum beta-lactamase found in Enterobacter cloacae. PMID:16251316 SHV-30 SHV-31 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-31 antibiotic_resistance ARO:3001089 SHV-31 ARO:3001089 SHV-31 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:17178800 SHV-31 SHV-32 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-32 antibiotic_resistance ARO:3001090 SHV-32 ARO:3001090 SHV-32 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:11557480 SHV-32 SHV-33 is an broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-33 antibiotic_resistance ARO:3001091 SHV-33 ARO:3001091 SHV-33 is an broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:11557480 SHV-33 SHV-34 is an extended-spectrum beta-lactamase found in E. coli. SHV-34 antibiotic_resistance ARO:3001092 SHV-34 ARO:3001092 SHV-34 is an extended-spectrum beta-lactamase found in E. coli. PMID:14613945 SHV-34 SHV-35 is a beta-lactamase found in Klebsiella pneumoniae. SHV-35 antibiotic_resistance ARO:3001093 SHV-35 ARO:3001093 SHV-35 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15047521 SHV-35 SHV-36 is a beta-lactamase found in Klebsiella pneumoniae. SHV-36 antibiotic_resistance ARO:3001094 SHV-36 ARO:3001094 SHV-36 is a beta-lactamase found in Klebsiella pneumoniae. PMID:17913717 SHV-36 SHV-37 is a beta-lactamase found in Klebsiella pneumoniae. SHV-37 antibiotic_resistance ARO:3001095 SHV-37 ARO:3001095 SHV-37 SHV-38 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-38 antibiotic_resistance ARO:3001096 SHV-38 ARO:3001096 SHV-38 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:12543688 SHV-38 SHV-39 is an extended-spectrum beta-lactamase that has been found in clinical isolates. SHV-39 antibiotic_resistance ARO:3001097 SHV-39 ARO:3001097 SHV-39 SHV-40 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-40 antibiotic_resistance ARO:3001098 SHV-40 ARO:3001098 SHV-40 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:15047521 SHV-40 SHV-41 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-41 antibiotic_resistance ARO:3001099 SHV-41 ARO:3001099 SHV-41 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:15047521 SHV-41 SHV-42 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-42 antibiotic_resistance ARO:3001100 SHV-42 ARO:3001100 SHV-42 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:15047521 SHV-42 SHV-43 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-43 antibiotic_resistance ARO:3001101 SHV-43 ARO:3001101 SHV-43 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:12543694 SHV-43 SHV-44 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-44 antibiotic_resistance ARO:3001102 SHV-44 ARO:3001102 SHV-44 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:14576109 SHV-44 SHV-45 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-45 antibiotic_resistance ARO:3001103 SHV-45 ARO:3001103 SHV-45 SHV-46 is an extended-spectrum beta-lactamase found in Klebsiella oxytoca. SHV-46 antibiotic_resistance ARO:3001104 SHV-46 ARO:3001104 SHV-46 is an extended-spectrum beta-lactamase found in Klebsiella oxytoca. PMID:14638498 SHV-46 SHV-48 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-48 antibiotic_resistance ARO:3001105 SHV-48 ARO:3001105 SHV-48 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19075050 SHV-48 SHV-49 is an inhibitor-resistant beta-lactamase found in Klebsiella pneumoniae. SHV-49 antibiotic_resistance ARO:3001106 SHV-49 ARO:3001106 SHV-49 is an inhibitor-resistant beta-lactamase found in Klebsiella pneumoniae. PMID:15504885 SHV-49 SHV-50 is a beta-lactamase found in Klebsiella pneumoniae. SHV-50 antibiotic_resistance ARO:3001107 SHV-50 ARO:3001107 SHV-50 SHV-51 is a beta-lactamase found in Klebsiella pneumoniae. SHV-51 antibiotic_resistance ARO:3001108 SHV-51 ARO:3001108 SHV-51 SHV-52 is a beta-lactamase that has been found in clinical isolates. SHV-52 antibiotic_resistance ARO:3001109 SHV-52 ARO:3001109 SHV-52 SHV-53 is a beta-lactamase that has been found in clinical isolates. SHV-53 antibiotic_resistance ARO:3001110 SHV-53 ARO:3001110 SHV-53 SHV-55 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-55 antibiotic_resistance ARO:3001111 SHV-55 ARO:3001111 SHV-55 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:16938422 SHV-55 SHV-56 is an inhibitor-resistant beta-lactamase found in Klebsiella pneumoniae. SHV-56 antibiotic_resistance ARO:3001112 SHV-56 ARO:3001112 SHV-56 is an inhibitor-resistant beta-lactamase found in Klebsiella pneumoniae. PMID:18663019 SHV-56 SHV-57 is an extended-spectrum beta-lactamase found in E. coli. SHV-57 antibiotic_resistance ARO:3001113 SHV-57 ARO:3001113 SHV-57 is an extended-spectrum beta-lactamase found in E. coli. PMID:15673739 SHV-57 SHV-59 is a beta-lactamase found in Klebsiella pneumoniae. SHV-59 antibiotic_resistance ARO:3001114 SHV-59 ARO:3001114 SHV-59 SHV-60 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-60 antibiotic_resistance ARO:3001115 SHV-60 ARO:3001115 SHV-60 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19272757 SHV-60 SHV-61 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-61 antibiotic_resistance ARO:3001116 SHV-61 ARO:3001116 SHV-61 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19272757 SHV-61 SHV-62 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-62 antibiotic_resistance ARO:3001117 SHV-62 ARO:3001117 SHV-62 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19272757 SHV-62 SHV-63 is a beta-lactamase found in Klebsiella pneumoniae. SHV-63 antibiotic_resistance ARO:3001118 SHV-63 ARO:3001118 SHV-63 SHV-64 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-64 antibiotic_resistance ARO:3001119 SHV-64 ARO:3001119 SHV-64 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:17288792 SHV-64 SHV-65 is a beta-lactamase found in Klebsiella pneumoniae. SHV-65 antibiotic_resistance ARO:3001120 SHV-65 ARO:3001120 SHV-65 is a beta-lactamase found in Klebsiella pneumoniae. PMID:17288792 SHV-65 SHV-66 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-66 antibiotic_resistance ARO:3001121 SHV-66 ARO:3001121 SHV-66 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:17288792 SHV-66 SHV-67 is a beta-lactamase found in Klebsiella pneumoniae. SHV-67 antibiotic_resistance ARO:3001122 SHV-67 ARO:3001122 SHV-67 is a beta-lactamase found in Klebsiella pneumoniae. PMID:17288792 SHV-67 SHV-69 is a beta-lactamase found in Klebsiella pneumoniae. SHV-69 antibiotic_resistance ARO:3001123 SHV-69 ARO:3001123 SHV-69 is a beta-lactamase found in Klebsiella pneumoniae. PMID:17288792 SHV-69 SHV-70 is an extended-spectrum beta-lactamase found in Enterobacter cloacae. SHV-70 antibiotic_resistance ARO:3001124 SHV-70 ARO:3001124 SHV-70 is an extended-spectrum beta-lactamase found in Enterobacter cloacae. PMID:16563703 SHV-70 SHV-71 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae and Shigella. SHV-71 antibiotic_resistance ARO:3001125 SHV-71 ARO:3001125 SHV-71 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae and Shigella. PMID:19272757 SHV-71 SHV-72 is an inhibitor-resistant beta-lactamase found in Klebsiella pneumoniae. SHV-72 antibiotic_resistance ARO:3001126 SHV-72 ARO:3001126 SHV-72 is an inhibitor-resistant beta-lactamase found in Klebsiella pneumoniae. PMID:18316518 SHV-72 SHV-73 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-73 antibiotic_resistance ARO:3001127 SHV-73 ARO:3001127 SHV-73 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19272757 SHV-73 SHV-74 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-74 antibiotic_resistance ARO:3001128 SHV-74 ARO:3001128 SHV-74 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19272757 SHV-74 SHV-75 is a broad-spectrum beta-lactamase that is found in clinical isolates. SHV-75 antibiotic_resistance ARO:3001129 SHV-75 ARO:3001129 SHV-75 is a broad-spectrum beta-lactamase that is found in clinical isolates. PMID:19272757 SHV-75 SHV-76 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-76 antibiotic_resistance ARO:3001130 SHV-76 ARO:3001130 SHV-76 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19272757 SHV-76 SHV-77 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae and E. coli. SHV-77 antibiotic_resistance ARO:3001131 SHV-77 ARO:3001131 SHV-77 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae and E. coli. PMID:19272757 SHV-77 SHV-78 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-78 antibiotic_resistance ARO:3001132 SHV-78 ARO:3001132 SHV-78 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19272757 SHV-78 SHV-79 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-79 antibiotic_resistance ARO:3001133 SHV-79 ARO:3001133 SHV-79 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19272757 SHV-79 SHV-80 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-80 antibiotic_resistance ARO:3001134 SHV-80 ARO:3001134 SHV-80 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19272757 SHV-80 SHV-81 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-81 antibiotic_resistance ARO:3001135 SHV-81 ARO:3001135 SHV-81 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19272757 SHV-81 SHV-82 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-82 antibiotic_resistance ARO:3001136 SHV-82 ARO:3001136 SHV-82 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19272757 SHV-82 SHV-83 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-83 antibiotic_resistance ARO:3001137 SHV-83 ARO:3001137 SHV-83 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19272757 SHV-83 SHV-84 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. SHV-84 antibiotic_resistance ARO:3001138 SHV-84 ARO:3001138 SHV-84 is an inhibitor-resistant beta-lactamase that has been found in clinical isolates. PMID:20211886 SHV-84 SHV-85 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-85 antibiotic_resistance ARO:3001139 SHV-85 ARO:3001139 SHV-85 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:18347108 SHV-85 SHV-86 is an extended-spectrum beta-lactamase that has been found in clinical isolates. SHV-86 antibiotic_resistance ARO:3001140 SHV-86 ARO:3001140 SHV-86 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:20566419 SHV-86 SHV-89 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-89 antibiotic_resistance ARO:3001141 SHV-89 ARO:3001141 SHV-89 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:18587684 SHV-89 SHV-90 is an extended-spectrum beta-lactamase that has been found in clinical isolates. Sequence data unavailable. antibiotic_resistance ARO:3001142 SHV-90 ARO:3001142 SHV-90 is an extended-spectrum beta-lactamase that has been found in clinical isolates. Sequence data unavailable. PMID:17913717 SHV-91 is an extended-spectrum beta-lactamase that has been found in clinical isolates. Sequence data unavailable. antibiotic_resistance ARO:3001143 SHV-91 ARO:3001143 SHV-91 is an extended-spectrum beta-lactamase that has been found in clinical isolates. Sequence data unavailable. PMID:17913717 SHV-92 is a beta-lactamase found in Klebsiella pneumoniae. SHV-92 antibiotic_resistance ARO:3001144 SHV-92 ARO:3001144 SHV-92 is a beta-lactamase found in Klebsiella pneumoniae. PMID:18029415 SHV-92 SHV-93 is a beta-lactamase found in Klebsiella pneumoniae. SHV-93 antibiotic_resistance ARO:3001145 SHV-93 ARO:3001145 SHV-93 SHV-94 is a beta-lactamase found in Klebsiella pneumoniae. SHV-94 antibiotic_resistance ARO:3001146 SHV-94 ARO:3001146 SHV-94 SHV-95 is a beta-lactamase found in Citrobacter freundii. SHV-95 antibiotic_resistance ARO:3001147 SHV-95 ARO:3001147 SHV-95 is a beta-lactamase found in Citrobacter freundii. PMID:21383920 SHV-95 SHV-96 is a beta-lactamase found in Acinetobacter baumannii. SHV-96 antibiotic_resistance ARO:3001148 SHV-96 ARO:3001148 SHV-96 SHV-97 is a beta-lactamase found in Enterococcus faecalis. SHV-97 antibiotic_resistance ARO:3001149 SHV-97 ARO:3001149 SHV-97 is a beta-lactamase found in Enterococcus faecalis. PMID:21940649 SHV-97 SHV-101 is a beta-lactamase found in Klebsiella pneumoniae. SHV-101 antibiotic_resistance ARO:3001150 SHV-101 ARO:3001150 SHV-101 is a beta-lactamase found in Klebsiella pneumoniae. PMID:17804424 SHV-101 SHV-102 is an extended spectrum beta-lactamase found in E. coli. SHV-102 antibiotic_resistance ARO:3001151 SHV-102 ARO:3001151 SHV-102 is an extended spectrum beta-lactamase found in E. coli. PMID:18566158 SHV-102 SHV-103 is a beta-lactamase that has been found in clinical isolates. SHV-103 antibiotic_resistance ARO:3001152 SHV-103 ARO:3001152 SHV-103 is a beta-lactamase that has been found in clinical isolates. PMID:18620848 SHV-103 SHV-104 is an extended-spectrum beta-lactamase that has been found in clinical isolates. SHV-104 antibiotic_resistance ARO:3001153 SHV-104 ARO:3001153 SHV-104 SHV-105 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-105 antibiotic_resistance ARO:3001154 SHV-105 ARO:3001154 SHV-105 is an extended-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:19075050 SHV-105 SHV-106 is an extended-spectrum beta-lactamase that has been found in clinical isolates. SHV-106 antibiotic_resistance ARO:3001155 SHV-106 ARO:3001155 SHV-106 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:19272757 SHV-106 SHV-107 is an inhibitor-resistant beta-lactamase found in Klebsiella pneumoniae. SHV-107 antibiotic_resistance ARO:3001156 SHV-107 ARO:3001156 SHV-107 is an inhibitor-resistant beta-lactamase found in Klebsiella pneumoniae. PMID:19272757 SHV-107 SHV-108 is a beta-lactamase found in Klebsiella pneumoniae. SHV-108 antibiotic_resistance ARO:3001157 SHV-108 ARO:3001157 SHV-108 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19272757 PMID:27598630 SHV-108 SHV-109 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. SHV-109 antibiotic_resistance ARO:3001158 SHV-109 ARO:3001158 SHV-109 is a broad-spectrum beta-lactamase found in Klebsiella pneumoniae. PMID:18725449 SHV-109 SHV-110 is a beta-lactamase found in Klebsiella pneumoniae. SHV-110 antibiotic_resistance ARO:3001159 SHV-110 ARO:3001159 SHV-110 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19343954 PMID:27598630 SHV-110 SHV-111 is a beta-lactamase found in Klebsiella pneumoniae. SHV-111 antibiotic_resistance ARO:3001160 SHV-111 ARO:3001160 SHV-111 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19343954 SHV-111 SHV-112 is a beta-lactamase that has been found in clinical isolates. SHV-112 antibiotic_resistance ARO:3001161 SHV-112 ARO:3001161 SHV-112 is a beta-lactamase that has been found in clinical isolates. PMID:21123157 SHV-112 The beta-lactamase name SHV-113 has been depreciated. antibiotic_resistance ARO:3001162 SHV-113 ARO:3001162 The beta-lactamase name SHV-114 has been depreciated. antibiotic_resistance ARO:3001163 SHV-114 ARO:3001163 SHV-115 is an extended-spectrum beta-lactamase that has been found in clinical isolates. SHV-115 antibiotic_resistance ARO:3001164 SHV-115 ARO:3001164 SHV-115 SHV-116 is a beta-lactamase that has been found in clinical isolates. SHV-116 antibiotic_resistance ARO:3001165 SHV-116 ARO:3001165 SHV-116 The beta-lactamase name SHV-117 has been depreciated. antibiotic_resistance ARO:3001166 SHV-117 ARO:3001166 SHV-120 is a beta-lactamase that has been found in clinical isolates. SHV-120 antibiotic_resistance ARO:3001167 SHV-120 ARO:3001167 SHV-120 SHV-121 is a beta-lactamase that has been found in clinical isolates. Identical to SHV-136. SHV-121 SHV-136 antibiotic_resistance ARO:3001168 SHV-121 ARO:3001168 SHV-121 SHV-122 is a beta-lactamase that has been found in clinical isolates. SHV-122 SHV-122b antibiotic_resistance ARO:3001169 SHV-122 ARO:3001169 SHV-122 is a beta-lactamase that has been found in clinical isolates. PMID:21359845 SHV-122 SHV-123 is a beta-lactamase that has been found in clinical isolates. SHV-123 antibiotic_resistance ARO:3001170 SHV-123 ARO:3001170 SHV-123 is a beta-lactamase that has been found in clinical isolates. PMID:21903826 SHV-123 SHV-124 is a beta-lactamase that has been found in clinical isolates. SHV-124 antibiotic_resistance ARO:3001171 SHV-124 ARO:3001171 SHV-124 is a beta-lactamase that has been found in clinical isolates. PMID:21903826 SHV-124 SHV-125 is a beta-lactamase that has been found in clinical isolates. SHV-125 antibiotic_resistance ARO:3001172 SHV-125 ARO:3001172 SHV-125 is a beta-lactamase that has been found in clinical isolates. PMID:21903826 SHV-125 SHV-126 is a beta-lactamase that has been found in clinical isolates. SHV-126 antibiotic_resistance ARO:3001173 SHV-126 ARO:3001173 SHV-126 is a beta-lactamase that has been found in clinical isolates. PMID:21903826 SHV-126 SHV-127 is a beta-lactamase that has been found in clinical isolates. SHV-127 antibiotic_resistance ARO:3001174 SHV-127 ARO:3001174 SHV-127 is a beta-lactamase that has been found in clinical isolates. PMID:21903826 SHV-127 SHV-128 is an extended-spectrum beta-lactamase that has been found in clinical isolates. SHV-128 antibiotic_resistance ARO:3001175 SHV-128 ARO:3001175 SHV-128 SHV-129 is an extended-spectrum beta-lactamase that has been found in clinical isolates. SHV-129 antibiotic_resistance ARO:3001176 SHV-129 ARO:3001176 SHV-129 is an extended-spectrum beta-lactamase that has been found in clinical isolates. PMID:22322349 SHV-129 SHV-133 is a beta-lactamase. SHV-133 antibiotic_resistance ARO:3001177 SHV-133 ARO:3001177 SHV-133 is a beta-lactamase. PMID:24475919 SHV-133 SHV-134 is an extended-spectrum beta-lactamase. SHV-134 antibiotic_resistance ARO:3001178 SHV-134 ARO:3001178 SHV-134 is an extended-spectrum beta-lactamase. PMID:22005997 SHV-134 SHV-135 is a beta-lactamase. SHV-135 antibiotic_resistance ARO:3001179 SHV-135 ARO:3001179 SHV-135 is a beta-lactamase. PMID:23722448 SHV-135 SHV-137 is a beta-lactamase. SHV-137 antibiotic_resistance ARO:3001181 SHV-137 ARO:3001181 SHV-137 SHV-140 is a broad-spectrum beta-lactamase. SHV-140 antibiotic_resistance ARO:3001182 SHV-140 ARO:3001182 SHV-140 SHV-141 is a broad-spectrum beta-lactamase. SHV-141 antibiotic_resistance ARO:3001183 SHV-141 ARO:3001183 SHV-141 SHV-142 is a beta-lactamase. SHV-142 antibiotic_resistance ARO:3001184 SHV-142 ARO:3001184 SHV-142 is a beta-lactamase. PMID:22537112 SHV-142 SHV-145 is a beta-lactamase. SHV-145 antibiotic_resistance ARO:3001185 SHV-145 ARO:3001185 SHV-145 SHV-147 is a beta-lactamase. SHV-147 antibiotic_resistance ARO:3001186 SHV-147 ARO:3001186 SHV-147 is a beta-lactamase. PMID:23587957 SHV-147 SHV-148 is a beta-lactamase. SHV-148 antibiotic_resistance ARO:3001187 SHV-148 ARO:3001187 SHV-148 is a beta-lactamase. PMID:23587957 SHV-148 SHV-149 is a beta-lactamase. SHV-149 antibiotic_resistance ARO:3001188 SHV-149 ARO:3001188 SHV-149 is a beta-lactamase. PMID:23587957 SHV-149 SHV-150 is a beta-lactamase. SHV-150 antibiotic_resistance ARO:3001189 SHV-150 ARO:3001189 SHV-150 is a beta-lactamase. PMID:23587957 SHV-150 SHV-151 is a beta-lactamase. SHV-151 antibiotic_resistance ARO:3001190 SHV-151 ARO:3001190 SHV-151 is a beta-lactamase. PMID:23587957 SHV-151 SHV-152 is a beta-lactamase. SHV-152 antibiotic_resistance ARO:3001191 SHV-152 ARO:3001191 SHV-152 SHV-153 is a beta-lactamase. SHV-153 antibiotic_resistance ARO:3001192 SHV-153 ARO:3001192 SHV-153 is a beta-lactamase. PMID:23587957 SHV-153 SHV-154 is a beta-lactamase. SHV-154 antibiotic_resistance ARO:3001193 SHV-154 ARO:3001193 SHV-154 is a beta-lactamase. PMID:23587957 SHV-154 SHV-155 is a beta-lactamase. SHV-155 antibiotic_resistance ARO:3001194 SHV-155 ARO:3001194 SHV-155 is a beta-lactamase. PMID:23587957 SHV-155 SHV-156 is a beta-lactamase. SHV-156 antibiotic_resistance ARO:3001195 SHV-156 ARO:3001195 SHV-156 is a beta-lactamase. PMID:23587957 SHV-156 SHV-157 is a beta-lactamase. SHV-157 antibiotic_resistance ARO:3001196 SHV-157 ARO:3001196 SHV-157 is a beta-lactamase. PMID:23587957 SHV-157 SHV-158 is a beta-lactamase. SHV-158 antibiotic_resistance ARO:3001197 SHV-158 ARO:3001197 SHV-158 is a beta-lactamase. PMID:23587957 SHV-158 SHV-159 is a beta-lactamase. SHV-159 antibiotic_resistance ARO:3001198 SHV-159 ARO:3001198 SHV-159 is a beta-lactamase. PMID:23587957 SHV-159 SHV-160 is a beta-lactamase. SHV-160 antibiotic_resistance ARO:3001199 SHV-160 ARO:3001199 SHV-160 SHV-161 is a beta-lactamase. SHV-161 antibiotic_resistance ARO:3001200 SHV-161 ARO:3001200 SHV-161 is a beta-lactamase. PMID:23587957 SHV-161 SHV-162 is a beta-lactamase. SHV-162 antibiotic_resistance ARO:3001201 SHV-162 ARO:3001201 SHV-162 SHV-163 is a beta-lactamase. SHV-163 antibiotic_resistance ARO:3001202 SHV-163 ARO:3001202 SHV-163 is a beta-lactamase. PMID:23587957 SHV-163 SHV-165 is a beta-lactamase. SHV-165 antibiotic_resistance ARO:3001203 SHV-165 ARO:3001203 SHV-165 is a beta-lactamase. PMID:23587957 SHV-165 SHV-167 is a beta-lactamase. SHV-167 antibiotic_resistance ARO:3001204 SHV-167 ARO:3001204 SHV-167 is a beta-lactamase. PMID:24336426 SHV-167 A novel bleomycin resistance protein encoded by a metallo-beta-lactamase-associated ble gene. Expression of BRP(MBL) confers resistance to bleomycin and bleomycin-like antibiotics in Enterobacteriaceae and Acinetobacter, where it is co-expressed with an MBL and controlled by the same promoter region. BRP BRP(MBL) ble blmA blmS antibiotic_resistance ARO:3001205 BRP(MBL) ARO:3001205 A novel bleomycin resistance protein encoded by a metallo-beta-lactamase-associated ble gene. Expression of BRP(MBL) confers resistance to bleomycin and bleomycin-like antibiotics in Enterobacteriaceae and Acinetobacter, where it is co-expressed with an MBL and controlled by the same promoter region. PMID:18791008 PMID:22290943 BRP(MBL) Inactivation of an antibiotic by formation of a complex, preventing interaction of the antibiotic with its target. antibiotic_resistance ARO:3001206 antibiotic inactivation by sequestration ARO:3001206 Inactivation of an antibiotic by formation of a complex, preventing interaction of the antibiotic with its target. PMID:18791008 A gene whose product inactivates an antibiotic by formation of a complex, preventing interaction of the antibiotic with its target. antibiotic_resistance ARO:3001207 gene involved in antibiotic sequestration ARO:3001207 In methicillin sensitive S. aureus (MSSA), beta-lactams bind to native penicillin-binding proteins (PBPs) and disrupt synthesis of the cell membrane's peptidoglycan layer. In methicillin resistant S. aureus (MRSA), foreign PBP2a acquired by lateral gene transfer is able to perform peptidoglycan synthesis in the presence of beta-lactams. antibiotic_resistance ARO:3001208 methicillin resistant PBP2 ARO:3001208 In methicillin sensitive S. aureus (MSSA), beta-lactams bind to native penicillin-binding proteins (PBPs) and disrupt synthesis of the cell membrane's peptidoglycan layer. In methicillin resistant S. aureus (MRSA), foreign PBP2a acquired by lateral gene transfer is able to perform peptidoglycan synthesis in the presence of beta-lactams. PMID:12389036 PMID:15226303 PMID:21641281 PMID:22941897 PMID:2708325 PMID:6563036 A foreign PBP2a acquired by lateral gene transfer that able to perform peptidoglycan synthesis in the presence of beta-lactams. mecALGA251 mecC antibiotic_resistance ARO:3001209 mecC ARO:3001209 A foreign PBP2a acquired by lateral gene transfer that able to perform peptidoglycan synthesis in the presence of beta-lactams. PMID:21641281 PMID:22941897 PMID:23274660 PMID:28069659 mecC Multidrug resistance protein MdtM. ECK4328 JW4300 mdtM yjiO antibiotic_resistance ARO:3001214 mdtM ARO:3001214 Multidrug resistance protein MdtM. PMID:23221628 mdtM Multidrug resistance protein MdtH. mdtH antibiotic_resistance ARO:3001216 mdtH ARO:3001216 Multidrug resistance protein MdtH. PMID:15686558 PMID:19678712 mdtH Alternative dihydropteroate synthase dfr present on plasmids produces alternate proteins that are less sensitive to trimethoprim from inhibiting its role in folate synthesis, thus conferring trimethoprim resistance. antibiotic_resistance ARO:3001218 trimethoprim resistant dihydrofolate reductase dfr ARO:3001218 Alternative dihydropteroate synthase dfr present on plasmids produces alternate proteins that are less sensitive to trimethoprim from inhibiting its role in folate synthesis, thus conferring trimethoprim resistance. PMID:20169085 Elfamycins are molecules that inhibit bacterial elongation factor Tu (EF-Tu), a key protein which brings aminoacyl-tRNA (aa-tRNA) to the ribosome during protein synthesis. Elfamycins defined by their target (EF-Tu), rather than a conserved chemical backbone. Elfamycins follow two mechanisms to disrupt protein synthesis: 1. kirromycins and enacyloxin fix EF-Tu in the GTP bound conformation and lock EF-Tu onto the ribosome, and 2. pulvomycin and GE2270 cover the binding site of aa-tRNA disallowing EF-Tu from being charged with aa-tRNA. All elfamycins cause increased the affinity of EF-Tu for GTP. elfamycin antibiotic_resistance ARO:3001219 elfamycin antibiotic ARO:3001219 Elfamycins are molecules that inhibit bacterial elongation factor Tu (EF-Tu), a key protein which brings aminoacyl-tRNA (aa-tRNA) to the ribosome during protein synthesis. Elfamycins defined by their target (EF-Tu), rather than a conserved chemical backbone. Elfamycins follow two mechanisms to disrupt protein synthesis: 1. kirromycins and enacyloxin fix EF-Tu in the GTP bound conformation and lock EF-Tu onto the ribosome, and 2. pulvomycin and GE2270 cover the binding site of aa-tRNA disallowing EF-Tu from being charged with aa-tRNA. All elfamycins cause increased the affinity of EF-Tu for GTP. PMID:12370016 PMID:16876786 Factumycin is a kirromycin-like antibiotic produced by Kitasatospora setae and Streptomyces strains. Its biosynthetic cluster has been characterized which has interesting acetyl transferase domains in trans, or outside of the polyketide synthase domains. Factumycin has specific, rather than broad spectrum, antibacterial properties, especially targeting various Acinetobacter baumanii strains. ChEBI:216503 ChEMBL:CHEMBL3218567 PubChem:135410114 antibiotic_resistance ARO:3001220 factumycin ARO:3001220 Factumycin is a kirromycin-like antibiotic produced by Kitasatospora setae and Streptomyces strains. Its biosynthetic cluster has been characterized which has interesting acetyl transferase domains in trans, or outside of the polyketide synthase domains. Factumycin has specific, rather than broad spectrum, antibacterial properties, especially targeting various Acinetobacter baumanii strains. PMID:7166535 A macrolide antibiotic from Streptomyces narbonensis subsp. josamyceticus. The drug has antimicrobial activity against a wide spectrum of pathogens. CAS:16846-24-5 ChEBI:31739 ChEMBL:CHEMBL224436 PubChem:5284579 antibiotic_resistance ARO:3001221 josamycin ARO:3001221 Produced by Streptomyces bikiniensis. CAS:20283-48-1 ChEBI:80016 ChEMBL:CHEMBL4076923 PubChem:6436271 antibiotic_resistance ARO:3001222 chalcomycin ARO:3001222 Produced by Streptomyces mycarofaciens. CAS:35457-80-8 ChEBI:31845 ChEMBL:CHEMBL1908336 PubChem:5282169 antibiotic_resistance ARO:3001223 midecamycin ARO:3001223 Produced by Micromonospora griseorubida. ChEBI:63276 PubChem:6447311 antibiotic_resistance ARO:3001224 mycinamicin ARO:3001224 Produced by Micromonospora megalomicia. ChEMBL:CHEMBL3990195 PubChem:474871 antibiotic_resistance ARO:3001225 megalomycin ARO:3001225 Produced by Streptomyces narbonensis. CAS:6036-25-5 ChEBI:29649 ChEMBL:CHEMBL1999880 PubChem:5282036 antibiotic_resistance ARO:3001226 narbomycin ARO:3001226 Kitasamycin is a macrolide antibiotic and is produced by Streptoverticillium kitasatoense. The drug has antimicrobial activity against a wide spectrum of pathogens. CAS:16846-24-5 ChEBI:31739 ChEMBL:CHEMBL2106399 PubChem:5282189 antibiotic_resistance ARO:3001227 kitasamycin ARO:3001227 Kitasamycin is a macrolide antibiotic and is produced by Streptoverticillium kitasatoense. The drug has antimicrobial activity against a wide spectrum of pathogens. PMID:1838760 Produced by Streptomyces halstedii and Streptomyces thermotolerans. ChEMBL:CHEMBL3989435 PubChem:5287879 antibiotic_resistance ARO:3001228 carbomycin ARO:3001228 Produced by Micromonospora rosaria. CAS:35834-26-5 ChEBI:87084 ChEMBL:CHEMBL8965 PubChem:6537204 antibiotic_resistance ARO:3001229 rosaramicin ARO:3001229 Produced by Streptomyces caelestis. CAS:20283-69-6 ChEBI:31908 PubChem:6440864 antibiotic_resistance ARO:3001230 niddamycin ARO:3001230 Produced by Streptomyces caelestis, which also produces the macrolide niddamycin. CAS:2520-21-0 ChEBI:156421 PubChem:220087 antibiotic_resistance ARO:3001231 celesticetin ARO:3001231 Produced by Streptomyces venezuelae ATCC 15439. CAS:497-72-3 ChEBI:29630 ChEMBL:CHEMBL489347 PubChem:5282034 antibiotic_resistance ARO:3001232 methymycin ARO:3001232 Produced by Streptomyces venezuelae ATCC 15439. CAS:19721-56-3 ChEBI:29665 PubChem:5282037 antibiotic_resistance ARO:3001233 pikromycin ARO:3001233 Kirromycin, also known as mocimycin, is the representative molecule of its own class of elfamycins which is composed of more than 10 analogs. Kirromycin binds to the domain 1,2 interface of elongation factor Tu. This interaction maintains the EF-Tu*GTP conformation even after GTP is hydrolyzed to GDP. EF-Tu*GDP normally releases aa-tRNA and then exits the ribosome; however, kirromycin*EF-Tu*GDP*aa-tRNA forms a strong complex and remains bound to the ribosome, prohibits translocation of the peptide chain and translation is halted. CAS:50935-71-2 ChEBI:190786 ChEMBL:CHEMBL4297102 PubChem:135452521 mocimycin antibiotic_resistance ARO:3001234 kirromycin ARO:3001234 Kirromycin, also known as mocimycin, is the representative molecule of its own class of elfamycins which is composed of more than 10 analogs. Kirromycin binds to the domain 1,2 interface of elongation factor Tu. This interaction maintains the EF-Tu*GTP conformation even after GTP is hydrolyzed to GDP. EF-Tu*GDP normally releases aa-tRNA and then exits the ribosome; however, kirromycin*EF-Tu*GDP*aa-tRNA forms a strong complex and remains bound to the ribosome, prohibits translocation of the peptide chain and translation is halted. PMID:2499247 PMID:3356609 PMID:337296 PMID:3904612 PMID:4373734 PMID:7925958 PMID:9043138 Aurodox is an elongation factor Tu inhibiting antibiotic. It was first referred to as X-5108. It is produced by Streptomyces goldiniensis var. goldiniensis and is active primarily against gram-positive bacteria. ChEBI:201478 ChEMBL:CHEMBL3221419 PubChem:135509117 antibiotic X-5108 goldinodox goldinomycin mocimycin antibiotic_resistance ARO:3001235 aurodox ARO:3001235 Aurodox is an elongation factor Tu inhibiting antibiotic. It was first referred to as X-5108. It is produced by Streptomyces goldiniensis var. goldiniensis and is active primarily against gram-positive bacteria. PMID:4781274 Efrotomycin is produced by Streptomyces lactamodurans NRRL 3802. This kirromycin-like antibiotic is used in animal agriculture, especially in the production of swine. Generally gram negative bacteria are susceptible to efrotomycin, while gram positive bacteria are resistant. ChEMBL:CHEMBL2106443 PubChem:135434844 antibiotic_resistance ARO:3001236 efrotomycin ARO:3001236 Efrotomycin is produced by Streptomyces lactamodurans NRRL 3802. This kirromycin-like antibiotic is used in animal agriculture, especially in the production of swine. Generally gram negative bacteria are susceptible to efrotomycin, while gram positive bacteria are resistant. PMID:1590753 PMID:16677683 PMID:8515234 PMID:950325 GE2270A is the model molecule of cyclic thiazolyl peptide elfamycins. GE2270A is produced by Planobispora rosea. Biosynthesis of the molecule has been shown to originate as a ribosomally synthesized peptide that undergoes significant post-translational modification. Clinical use of cyclic thiazolyl peptides is hindered by their low water solubility and bioavailability. ChEBI:29584 ChEMBL:CHEMBL1766417 PubChem:16129640 antibiotic_resistance ARO:3001237 GE2270A ARO:3001237 GE2270A is the model molecule of cyclic thiazolyl peptide elfamycins. GE2270A is produced by Planobispora rosea. Biosynthesis of the molecule has been shown to originate as a ribosomally synthesized peptide that undergoes significant post-translational modification. Clinical use of cyclic thiazolyl peptides is hindered by their low water solubility and bioavailability. PMID:10625477 PMID:16734421 PMID:20111801 PMID:20522549 PMID:8899707 Enacyloxin IIa is structurally distinct but acts in a similar mechanism to kirromycin-like elfamycins. It prohibits the transfer of the amino acid at the A site to the elongating peptide chain. It is most likely that the mechanism of action is that EF-Tu*GDP is locked in the EF-Tu*GTP form, and EF-Tu*GDP*aa-tRNA is immobilized on the ribosome. It is an open question whether enacyloxin IIa actually belongs to the kirromycin-like group of elfamycins due to their high similarity. ChEMBL:CHEMBL5282611 PubChem:6444164 antibiotic_resistance ARO:3001242 enacyloxin IIa ARO:3001242 Enacyloxin IIa is structurally distinct but acts in a similar mechanism to kirromycin-like elfamycins. It prohibits the transfer of the amino acid at the A site to the elongating peptide chain. It is most likely that the mechanism of action is that EF-Tu*GDP is locked in the EF-Tu*GTP form, and EF-Tu*GDP*aa-tRNA is immobilized on the ribosome. It is an open question whether enacyloxin IIa actually belongs to the kirromycin-like group of elfamycins due to their high similarity. PMID:12370016 PMID:8665868 Kirrothricin is produced by Streptomyces cinnamoneus and is structurally related to kirromycin, aurodox, heneicomycin and shares a similar spectrum of antibacterial activity. ChEBI:223261 PubChem:54679291 antibiotic_resistance ARO:3001246 kirrothricin ARO:3001246 Kirrothricin is produced by Streptomyces cinnamoneus and is structurally related to kirromycin, aurodox, heneicomycin and shares a similar spectrum of antibacterial activity. PMID:7142013 Azimycin is produced by Streptomyces diastatochromogenes ATCC 31013. CAS:50-02-2 ChEBI:41879 ChEMBL:CHEMBL384467 PubChem:5743 antibiotic_resistance ARO:3001247 azimycin ARO:3001247 Azimycin is produced by Streptomyces diastatochromogenes ATCC 31013. PMID:3904612 Dihydromocimycin is produced by Streptomyces ramocissimus CBS190.69. PubChem:54679334 antibiotic_resistance ARO:3001248 dihydromocimycin ARO:3001248 Dihydromocimycin is produced by Streptomyces ramocissimus CBS190.69. PMID:2272911 PMID:3781906 Phenelfamycin A was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin A has a monosaccaride moeity and is isomeric with phenelfamycin B. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. ChEBI:222054 PubChem:6443943 antibiotic_resistance ARO:3001249 phenelfamycin A ARO:3001249 Phenelfamycin A was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin A has a monosaccaride moeity and is isomeric with phenelfamycin B. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. PMID:2921230 PMID:3192489 PMID:3192490 Phenelfamycin B was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin B has a monosaccaride moeity and is isomeric with phenelfamycin A. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. ChEBI:222047 PubChem:6443944 antibiotic_resistance ARO:3001250 phenelfamycin B ARO:3001250 Phenelfamycin B was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin B has a monosaccaride moeity and is isomeric with phenelfamycin A. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. PMID:2921230 PMID:3192489 PMID:3192490 Phenelfamycin C was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin C has a disaccaride moeity and is isomeric with phenelfamycin D. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. ChEBI:222040 PubChem:6443945 antibiotic_resistance ARO:3001251 phenelfamycin C ARO:3001251 Phenelfamycin C was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin C has a disaccaride moeity and is isomeric with phenelfamycin D. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. PMID:2921230 PMID:3192489 PMID:3192490 Phenelfamycin D was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin D has a disaccaride moeity and is isomeric with phenelfamycin C. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. antibiotic_resistance ARO:3001252 phenelfamycin D ARO:3001252 Phenelfamycin D was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin D has a disaccaride moeity and is isomeric with phenelfamycin C. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. PMID:2921230 PMID:3192489 PMID:3192490 Phenelfamycin E was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin E has a trisaccaride moeity and is isomeric with phenelfamycin F. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. Phenelfamycin E and F are the most potent of the phenelfamycins. ChEBI:222034 PubChem:71433564 antibiotic_resistance ARO:3001253 phenelfamycin E ARO:3001253 Phenelfamycin E was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin E has a trisaccaride moeity and is isomeric with phenelfamycin F. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. Phenelfamycin E and F are the most potent of the phenelfamycins. PMID:2921230 PMID:3192489 PMID:3192490 Phenelfamycin F was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin F has a trisaccaride moeity and is isomeric with phenelfamycin E. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. Phenelfamycin E and F are the most potent of the phenelfamycins. ChEBI:222028 PubChem:90478571 antibiotic_resistance ARO:3001256 phenelfamycin F ARO:3001256 Phenelfamycin F was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin F has a trisaccaride moeity and is isomeric with phenelfamycin E. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. Phenelfamycin E and F are the most potent of the phenelfamycins. PMID:2921230 PMID:3192489 PMID:3192490 Unphenelfamycin was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Unphenelfamycin has a monosaccaride moeity and lacks the phenacetyl moeity present in the other phenelfamycins. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. ChEBI:222022 PubChem:6443942 antibiotic_resistance ARO:3001257 unphenelfamycin ARO:3001257 Unphenelfamycin was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Unphenelfamycin has a monosaccaride moeity and lacks the phenacetyl moeity present in the other phenelfamycins. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. PMID:2921230 PMID:3192489 PMID:3192490 L-681217 is a kirromycin-like antibiotic produced by Streptomyces cattleya. Its biosynthetic gene cluster is characterized. ChEBI:201407 PubChem:6439903 antibiotic_resistance ARO:3001258 L-681,217 ARO:3001258 L-681217 is a kirromycin-like antibiotic produced by Streptomyces cattleya. Its biosynthetic gene cluster is characterized. PMID:3781906 GE37468 is a thiazolyl peptide produced by Streptomyces ATCC 55365. GE37468 is produced by post-transcription modification of a ribosomally synthesized preprotein, of which the biosynthetic gene cluster has been elucidated. ChEBI:199144 ChEMBL:CHEMBL4646154 PubChem:101808822 antibiotic_resistance ARO:3001259 GE37468 ARO:3001259 GE37468 is a thiazolyl peptide produced by Streptomyces ATCC 55365. GE37468 is produced by post-transcription modification of a ribosomally synthesized preprotein, of which the biosynthetic gene cluster has been elucidated. PMID:21788474 Amythiamicin A is a cyclic thiazolyl peptide antibiotic with a structure similar to GE2270A. Amythiamicin B, C, and D also exist, but are not discussed further here. Amythiamicin A was shown to have the highest activity in cell free protein synthesis assays. ChEBI:220214 PubChem:198789 antibiotic_resistance ARO:3001260 amythiamicin A ARO:3001260 Amythiamicin A is a cyclic thiazolyl peptide antibiotic with a structure similar to GE2270A. Amythiamicin B, C, and D also exist, but are not discussed further here. Amythiamicin A was shown to have the highest activity in cell free protein synthesis assays. PMID:7706132 Heneicomycin is a kirromycin-like antibiotic, isolated from Streptomyces filipinensis. It is structurally related to kirromycin, aurodox and efrotomycin. PubChem:135612719 antibiotic_resistance ARO:3001264 heneicomycin ARO:3001264 Heneicomycin is a kirromycin-like antibiotic, isolated from Streptomyces filipinensis. It is structurally related to kirromycin, aurodox and efrotomycin. PMID:1917698 PMID:468738 Erm(30) confers a MLSb resistant phenotype. Along with erm(31), these genes are responsible for self-resistance in the pikromycin/narbomycin/methymycin/neomethymycin producer, Streptomyces venezuelae. Erm(30) Erm30 antibiotic_resistance ARO:3001265 Erm(30) ARO:3001265 Erm(30) confers a MLSb resistant phenotype. Along with erm(31), these genes are responsible for self-resistance in the pikromycin/narbomycin/methymycin/neomethymycin producer, Streptomyces venezuelae. PMID:14674753 PMID:9770448 Erm(30) A gentamicin-group aminoglycoside isolated from Micromonospora. ChEMBL:CHEMBL1276546 PubChem:512877 antibiotic_resistance ARO:3001294 verdamicin ARO:3001294 A semisynthetic genamicin-group aminoglycoside, derived from verdamicin. ChEMBL:CHEMBL1276545 PubChem:52948322 antibiotic_resistance ARO:3001295 vertilimicin ARO:3001295 A semisynthetic genamicin-group aminoglycoside, derived from verdamicin. PMID:19635958 An unusual aminoglycoside because the cyclitol ring is not amino substituted; it was discovered as a fermentation product of Streptomyces kasugaensis. CAS:6980-18-3 ChEBI:81419 ChEMBL:CHEMBL1631109 PubChem:65174 kasugamicin antibiotic_resistance ARO:3001296 kasugamycin ARO:3001296 Non-erm 23S ribosomal RNA methyltransferases modify guanosine 748 (E. coli numbering) to confer resistance to some macrolides and lincosamides. antibiotic_resistance ARO:3001298 non-erm 23S ribosomal RNA methyltransferase (G748) ARO:3001298 TlrB is a methyltransferase found in Streptomyces fradiae and confers resistance to mycinamicin, tylosin and lincosamides. Specifically, this enzyme adds a methyl group to guanosine 748 (E. coli numbering). TlrB is found in the tylosin biosynthetic cluster and is one mechanism by which S. fradiae protects itself from self-destruction when producing this macrolide. Sfra_tlrB_TYL antibiotic_resistance ARO:3001299 tlrB conferring tylosin resistance ARO:3001299 TlrB is a methyltransferase found in Streptomyces fradiae and confers resistance to mycinamicin, tylosin and lincosamides. Specifically, this enzyme adds a methyl group to guanosine 748 (E. coli numbering). TlrB is found in the tylosin biosynthetic cluster and is one mechanism by which S. fradiae protects itself from self-destruction when producing this macrolide. PMID:10348045 PMID:10972803 Sfra_tlrB_TYL myrA is a methyltransferase found in Micromonospora griseorubida and confers resistance to mycinamicin and tylosin. Specifically, this enzyme adds a methyl group to guanosine 748 (E. coli numbering) of 23S ribosomal RNA. MyrA is found in the mycinamicin biosynthetic cluster and is one mechanism by which M. griseorubida protects itself from self-destruction when producing this macrolide. myrA antibiotic_resistance ARO:3001300 myrA ARO:3001300 myrA is a methyltransferase found in Micromonospora griseorubida and confers resistance to mycinamicin and tylosin. Specifically, this enzyme adds a methyl group to guanosine 748 (E. coli numbering) of 23S ribosomal RNA. MyrA is found in the mycinamicin biosynthetic cluster and is one mechanism by which M. griseorubida protects itself from self-destruction when producing this macrolide. PMID:12417742 PMID:8163173 myrA RlmA(II) is a methyltransferase found in Streptococcus pneumoniae and confers resistance to tylosin and mycinamicin. Specifically, this enzyme adds a methyl group to guanosine 748 (E. coli numbering) of 23S ribosomal RNA. RlmA(II) antibiotic_resistance ARO:3001301 RlmA(II) ARO:3001301 RlmA(II) is a methyltransferase found in Streptococcus pneumoniae and confers resistance to tylosin and mycinamicin. Specifically, this enzyme adds a methyl group to guanosine 748 (E. coli numbering) of 23S ribosomal RNA. PMID:12514124 PMID:18406425 RlmA(II) ChrB is a methyltransferase found in Streptomyces bikiniensis and confers resistance to chalcomycin, mycinamicin, and tylosin. Specifically, this enzyme adds a methyl group to guanosine 748 (E. coli numbering). chrB is found in the chalcomycin biosynthetic cluster and is responsible for self-resistance in S. bikiniensis. chrB antibiotic_resistance ARO:3001302 chrB ARO:3001302 ChrB is a methyltransferase found in Streptomyces bikiniensis and confers resistance to chalcomycin, mycinamicin, and tylosin. Specifically, this enzyme adds a methyl group to guanosine 748 (E. coli numbering). chrB is found in the chalcomycin biosynthetic cluster and is responsible for self-resistance in S. bikiniensis. PMID:15561847 chrB ErmO (gene srmA) is a methyltransferase found in the spiramycin producer Streptomyces ambofaciens. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. Specifically, this enzyme transfers only one methyl group. The gene is responsible for self-resistance to spiramycin. ErmO-srmA srmA antibiotic_resistance ARO:3001303 ErmO-srmA ARO:3001303 ErmO (gene srmA) is a methyltransferase found in the spiramycin producer Streptomyces ambofaciens. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. Specifically, this enzyme transfers only one methyl group. The gene is responsible for self-resistance to spiramycin. PMID:10517588 PMID:1761231 ErmO-srmA ErmS is a methyltransferase found in the tylosin producer Streptomyces fradiae. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. Specifically, this enzyme transfers two methyl groups. The gene is found within the tylosin biosynthetic cluster and is responsible for self-resistance. ErmS ermSF tlrA antibiotic_resistance ARO:3001304 ErmS ARO:3001304 ErmS is a methyltransferase found in the tylosin producer Streptomyces fradiae. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. Specifically, this enzyme transfers two methyl groups. The gene is found within the tylosin biosynthetic cluster and is responsible for self-resistance. PMID:2753855 PMID:3020383 PMID:3127381 PMID:7495815 PMID:7534372 PMID:7961463 ErmS ErmU is a methyltransferase found in the lincomycin producer Streptomyces lincolnensis. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. Specifically, this enzyme transfers only one methyl group. The gene is found in the lincomycin biosynthetic cluster and is responsible for self-resistance. ErmU lrmB antibiotic_resistance ARO:3001305 ErmU ARO:3001305 ErmU is a methyltransferase found in the lincomycin producer Streptomyces lincolnensis. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. Specifically, this enzyme transfers only one methyl group. The gene is found in the lincomycin biosynthetic cluster and is responsible for self-resistance. PMID:1328813 PMID:8577249 ErmU ErmW is a methyltransferase found in the mycinamicin producer Micromonospora griseorubida. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. The gene is found within the mycinamicin biosynthetic cluster and is responsible for self-resistance. ErmW myrB antibiotic_resistance ARO:3001306 ErmW ARO:3001306 ErmW is a methyltransferase found in the mycinamicin producer Micromonospora griseorubida. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. The gene is found within the mycinamicin biosynthetic cluster and is responsible for self-resistance. PMID:12583909 PMID:8163173 ErmW vgbA inactivates streptogramin B-type antibiotics by linearizing the lactone ring on the ester bond using an elimination mechanism, thus conferring resistance to these compounds. PDB:2Z2P vgbA vgh antibiotic_resistance ARO:3001307 vgbA ARO:3001307 vgbA inactivates streptogramin B-type antibiotics by linearizing the lactone ring on the ester bond using an elimination mechanism, thus conferring resistance to these compounds. PMID:11467949 PMID:15734650 PMID:17563376 vgbA VgbB inactivates streptogramin B-type antibiotics by linearizing the lactone ring on the ester bond through an elimination mechanism, thus conferring resistance. vgbB antibiotic_resistance ARO:3001308 vgbB ARO:3001308 VgbB inactivates streptogramin B-type antibiotics by linearizing the lactone ring on the ester bond through an elimination mechanism, thus conferring resistance. PMID:18341294 vgbB Cyclic thiazolyl peptide elfamycins inhibit protein synthesis by preventing the formation of the EF-Tu*GTP-aa-tRNA ternary complex, a mechanism similar to that of pulvomycin. There are non-elfamycin cyclic thiazolyl peptide antibiotics which inhibit protein synthesis by by targeting the 50S ribosomal subunit and are not discussed here further. antibiotic_resistance ARO:3001309 cyclic thiazolyl peptide elfamycin ARO:3001309 Cyclic thiazolyl peptide elfamycins inhibit protein synthesis by preventing the formation of the EF-Tu*GTP-aa-tRNA ternary complex, a mechanism similar to that of pulvomycin. There are non-elfamycin cyclic thiazolyl peptide antibiotics which inhibit protein synthesis by by targeting the 50S ribosomal subunit and are not discussed here further. PMID:12370016 Kirromycin-like antibiotics bind to the domain 1,2 interface of elongation factor Tu. This interaction maintains the EF-Tu*GTP conformation even after GTP is hydrolyzed to GDP. EF-Tu*GDP normally releases aa-tRNA and then exits the ribosome; however, kirromycin*EF-Tu*GDP*aa-tRNA forms a strong complex and remains bound to the ribosome, prohibits translocation of the peptide chain and translation is halted. antibiotic_resistance ARO:3001310 kirromycin-like antibiotics ARO:3001310 Sequence variants of elongation factor Tu that confer resistance to elfamycin antibiotics. antibiotic_resistance ARO:3001312 elfamycin resistant EF-Tu ARO:3001312 Sequence variants of elongation factor Tu that confer resistance to elfamycin antibiotics. PMID:10610785 PMID:12370016 PMID:7525272 PMID:7925958 PMID:7957075 PMID:8899707 Efflux protein facT confers resistance to factumycin. The gene has been heterologously expressed in S. coelicolor and its function confirmed. It is possible that this gene can export other kirromycin-like elfamycins, but this has not been tested. facT antibiotic_resistance ARO:3001313 facT ARO:3001313 Efflux protein facT confers resistance to factumycin. The gene has been heterologously expressed in S. coelicolor and its function confirmed. It is possible that this gene can export other kirromycin-like elfamycins, but this has not been tested. DOI:10.1039/C2MD20038D facT Retapamulin is a semi-synthetic pleuromutilin antibiotic approved for the treatment of skin infections. ChEBI:166679 ChEMBL:CHEMBL1658 PubChem:6918462 antibiotic_resistance ARO:3001314 retapamulin ARO:3001314 Retapamulin is a semi-synthetic pleuromutilin antibiotic approved for the treatment of skin infections. PMID:16801451 PMID:16940066 PMID:17065625 PMID:17360517 Two semi-synthetic pleuromutilin derivatives, tiamulin and valnemulin, have been developed as antibiotics for veterinary use. CAS:101312-92-9 ChEBI:29705 ChEMBL:CHEMBL1688852 PubChem:9850878 antibiotic_resistance ARO:3001315 valnemulin ARO:3001315 Two semi-synthetic pleuromutilin derivatives, tiamulin and valnemulin, have been developed as antibiotics for veterinary use. PMID:11555289 PMID:22070694 Azamulin is a semi-synthetic pleuromutilin derivative that failed Stage 1 clinical trials due to poor bioavailability. ChEBI:201468 ChEMBL:CHEMBL2103760 PubChem:16072188 antibiotic_resistance ARO:3001316 azamulin ARO:3001316 Pleuromutilin is a natural product antibiotic produced by Clitopilus passeckerianus. Related antibiotics of clinical significance, such as tiamulin and retapamulin, are semi-synthetic derivatives of this compound. CAS:125-65-5 ChEBI:8269 ChEMBL:CHEMBL3989485 PubChem:31326 antibiotic_resistance ARO:3001317 pleuromutilin ARO:3001317 Pleuromutilin is a natural product antibiotic produced by Clitopilus passeckerianus. Related antibiotics of clinical significance, such as tiamulin and retapamulin, are semi-synthetic derivatives of this compound. PMID:23589420 Narrow spectrum macrocyclic antibiotics, in the general sense, is a cyclic molecule containing more than 12 atoms in the macrocyclic lactone ring. antibiotic_resistance ARO:3001318 macrocyclic antibiotic ARO:3001318 Narrow spectrum macrocyclic antibiotics, in the general sense, is a cyclic molecule containing more than 12 atoms in the macrocyclic lactone ring. PMID:22142153 PMID:24864039 A narrow spectrum antibiotic effective against Clostridioides difficile infection (CDI). It is active against gram positive and gram negative bacteria by inhibiting RNA polymerase's switch region leading to cell death. CAS:873857-62-6 ChEBI:68590 ChEMBL:CHEMBL1255800 PubChem:10034073 OPT-80 antibiotic_resistance ARO:3001319 fidaxomicin ARO:3001319 A narrow spectrum antibiotic effective against Clostridioides difficile infection (CDI). It is active against gram positive and gram negative bacteria by inhibiting RNA polymerase's switch region leading to cell death. PMID:21288078 PMID:21862392 PMID:22752863 PMID:24064437 SB22484 antibiotics are of the same chemical group as kirromycins. SB22484 antibiotics are produced by Streptomyces sp. NRRL 15496. There are two SB22484 isomers with the same UV absorption spectra, but differing molecular masses. These antibiotics are strongly active against Neisseria species, but also show activity against Streptococci, and Haemophilus influenzae. ChEMBL:CHEMBL14563 PubChem:53418992 antibiotic_resistance ARO:3001320 SB22484 ARO:3001320 SB22484 antibiotics are of the same chemical group as kirromycins. SB22484 antibiotics are produced by Streptomyces sp. NRRL 15496. There are two SB22484 isomers with the same UV absorption spectra, but differing molecular masses. These antibiotics are strongly active against Neisseria species, but also show activity against Streptococci, and Haemophilus influenzae. PMID:2272911 UK-69,753 is a glycosylated form of factumycin. The disaccharide moiety of UK-69,753 is virtually identical to that of efrotomycin, another member of this class of antibiotics. UK-69,753 has been shown to have strong in vitro and in vivo activity toward a swine pathogen, Treponema hyodysenteriae. PubChem:54681521 antibiotic_resistance ARO:3001321 UK-69,753 ARO:3001321 UK-69,753 is a glycosylated form of factumycin. The disaccharide moiety of UK-69,753 is virtually identical to that of efrotomycin, another member of this class of antibiotics. UK-69,753 has been shown to have strong in vitro and in vivo activity toward a swine pathogen, Treponema hyodysenteriae. PMID:2584145 Phenelfamycin G is produced by Streptomyces albospinus strain Acta 3619. Phenelfamycin G and H are isomeric and similar to phenelfamycin E and F only with the addition of a hydroxyl group at position C-30. Phenelfamycin G and H have a narrow antibacterial spectrum with potent activity against Cutibacterium acnes. ChEBI:203584 PubChem:102306422 antibiotic_resistance ARO:3001322 phenelfamycin G ARO:3001322 Phenelfamycin G is produced by Streptomyces albospinus strain Acta 3619. Phenelfamycin G and H are isomeric and similar to phenelfamycin E and F only with the addition of a hydroxyl group at position C-30. Phenelfamycin G and H have a narrow antibacterial spectrum with potent activity against Cutibacterium acnes. PMID:21285962 Phenelfamycin H is produced by Streptomyces albospinus strain Acta 3619. Phenelfamycin G and H are isomeric and similar to phenelfamycin E and F only with the addition of a hydroxyl group at position C-30. Phenelfamycin G and H have a narrow antibacterial spectrum with potent activity against Cutibacterium acnes. ChEBI:225298 PubChem:102306423 antibiotic_resistance ARO:3001323 phenelfamycin H ARO:3001323 Phenelfamycin H is produced by Streptomyces albospinus strain Acta 3619. Phenelfamycin G and H are isomeric and similar to phenelfamycin E and F only with the addition of a hydroxyl group at position C-30. Phenelfamycin G and H have a narrow antibacterial spectrum with potent activity against Cutibacterium acnes. PMID:21285962 One of a small group of kirromycin-like elfamycins which lack the pyridone moiety. Ganefromycin is produced by Streptomyces lydicus spp. tanzanius, and was considered for use as a growth promoting antibiotic in agriculture. ChEBI:217601 ChEMBL:CHEMBL3989416 PubChem:134158049 antibiotic_resistance ARO:3001326 ganefromycin ARO:3001326 One of a small group of kirromycin-like elfamycins which lack the pyridone moiety. Ganefromycin is produced by Streptomyces lydicus spp. tanzanius, and was considered for use as a growth promoting antibiotic in agriculture. PMID:8557574 A multidrug and toxic compound extrusions (MATE) transporter conferring resistance to norfloxacin, doxorubicin and acriflavine. MdtK NorE YdhE norM antibiotic_resistance ARO:3001327 MdtK ARO:3001327 A multidrug and toxic compound extrusions (MATE) transporter conferring resistance to norfloxacin, doxorubicin and acriflavine. PMID:16359323 MdtK Multidrug efflux pump in E. coli. This multidrug efflux system was originally identified as the Cmr/CmlA chloramphenicol exporter. Ecol_mdfA cmlA cmr antibiotic_resistance ARO:3001328 Escherichia coli mdfA ARO:3001328 Multidrug efflux pump in E. coli. This multidrug efflux system was originally identified as the Cmr/CmlA chloramphenicol exporter. PMID:12578981 PMID:26238402 PMID:9811673 Ecol_mdfA The MdtG protein, also named YceE, appears to be a member of the major facilitator superfamily of transporters, and it has been reported, when overexpressed, to increase fosfomycin and deoxycholate resistances. mdtG is a member of the marA-soxS-rob regulon. mdtG yceE antibiotic_resistance ARO:3001329 mdtG ARO:3001329 The MdtG protein, also named YceE, appears to be a member of the major facilitator superfamily of transporters, and it has been reported, when overexpressed, to increase fosfomycin and deoxycholate resistances. mdtG is a member of the marA-soxS-rob regulon. PMID:20008776 mdtG SHV-54 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001331 SHV-54 ARO:3001331 SHV-58 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001332 SHV-58 ARO:3001332 SHV-68 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001333 SHV-68 ARO:3001333 SHV-87 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001334 SHV-87 ARO:3001334 SHV-88 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001335 SHV-88 ARO:3001335 SHV-98 is a beta-lactamase found in Klebsiella pneumoniae. SHV-98 antibiotic_resistance ARO:3001336 SHV-98 ARO:3001336 SHV-98 is a beta-lactamase found in Klebsiella pneumoniae. PMID:21415202 SHV-98 SHV-99 is a beta-lactamase found in Klebsiella pneumoniae. SHV-99 antibiotic_resistance ARO:3001337 SHV-99 ARO:3001337 SHV-99 is a beta-lactamase found in Klebsiella pneumoniae. PMID:21415202 PMID:27598630 SHV-99 SHV-100 is a beta-lactamase found in Klebsiella pneumoniae. It differs from SHV-1 by a 35SESQLSGRVGMIE36 insertion. SHV-100 antibiotic_resistance ARO:3001338 SHV-100 ARO:3001338 SHV-100 is a beta-lactamase found in Klebsiella pneumoniae. It differs from SHV-1 by a 35SESQLSGRVGMIE36 insertion. PMID:21415202 SHV-100 SHV-118 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001339 SHV-118 ARO:3001339 SHV-119 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. SHV-119 antibiotic_resistance ARO:3001340 SHV-119 ARO:3001340 SHV-119 SHV-132 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. SHV-132 antibiotic_resistance ARO:3001341 SHV-132 ARO:3001341 SHV-132 SHV-138 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001342 SHV-138 ARO:3001342 SHV-139 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001343 SHV-139 ARO:3001343 SHV-143 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. SHV-143 antibiotic_resistance ARO:3001344 SHV-143 ARO:3001344 SHV-143 SHV-144 is a beta-lactamase found in Klebsiella pneumoniae. SHV-144 antibiotic_resistance ARO:3001345 SHV-144 ARO:3001345 SHV-144 is a beta-lactamase found in Klebsiella pneumoniae. PMID:24270152 SHV-144 SHV-146 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. SHV-146 antibiotic_resistance ARO:3001346 SHV-146 ARO:3001346 SHV-146 SHV-164 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. SHV-164 antibiotic_resistance ARO:3001347 SHV-164 ARO:3001347 SHV-164 SHV-166 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001348 SHV-166 ARO:3001348 The beta-lactamase name SHV-174 has been depreciated. antibiotic_resistance ARO:3001349 SHV-174 ARO:3001349 SHV-180 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. SHV-180 antibiotic_resistance ARO:3001350 SHV-180 ARO:3001350 SHV-180 SHV-183 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. SHV-183 antibiotic_resistance ARO:3001351 SHV-183 ARO:3001351 SHV-183 SHV-168 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. SHV-168 antibiotic_resistance ARO:3001352 SHV-168 ARO:3001352 SHV-168 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. PMID:23587779 SHV-168 SHV-169 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001353 SHV-169 ARO:3001353 SHV-170 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001354 SHV-170 ARO:3001354 SHV-171 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. SHV-171 antibiotic_resistance ARO:3001355 SHV-171 ARO:3001355 SHV-171 SHV-172 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. SHV-172 antibiotic_resistance ARO:3001356 SHV-172 ARO:3001356 SHV-172 SHV-173 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. SHV-173 antibiotic_resistance ARO:3001357 SHV-173 ARO:3001357 SHV-173 SHV-175 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001358 SHV-175 ARO:3001358 SHV-176 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001359 SHV-176 ARO:3001359 SHV-176 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. PMID:24403301 SHV-177 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001360 SHV-177 ARO:3001360 SHV-178 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. SHV-178 antibiotic_resistance ARO:3001361 SHV-178 ARO:3001361 SHV-178 SHV-179 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. SHV-179 antibiotic_resistance ARO:3001362 SHV-179 ARO:3001362 SHV-179 SHV-181 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001363 SHV-181 ARO:3001363 SHV-182 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. SHV-182 antibiotic_resistance ARO:3001364 SHV-182 ARO:3001364 SHV-182 SHV-184 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001365 SHV-184 ARO:3001365 TEM-100 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001366 TEM-100 ARO:3001366 TEM-119 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001367 TEM-119 ARO:3001367 TEM-140 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001368 TEM-140 ARO:3001368 TEM-153 is a beta-lactamase found in Enterobacteriaceae. TEM-153 antibiotic_resistance ARO:3001369 TEM-153 ARO:3001369 TEM-153 is a beta-lactamase found in Enterobacteriaceae. PMID:23579192 TEM-153 TEM-175 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001370 TEM-175 ARO:3001370 TEM-179 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001371 TEM-179 ARO:3001371 TEM-180 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001372 TEM-180 ARO:3001372 TEM-182 is a beta-lactamase found in clinical isolates of H. parainfluenzae. TEM-182 antibiotic_resistance ARO:3001373 TEM-182 ARO:3001373 TEM-182 is a beta-lactamase found in clinical isolates of H. parainfluenzae. PMID:23335113 TEM-182 TEM-185 is a beta-lactamase found in E. coli. TEM-185 antibiotic_resistance ARO:3001374 TEM-185 ARO:3001374 TEM-185 is a beta-lactamase found in E. coli. PMID:22491692 TEM-185 TEM-184 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. TEM-184 antibiotic_resistance ARO:3001375 TEM-184 ARO:3001375 TEM-184 TEM-196 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. TEM-196 antibiotic_resistance ARO:3001376 TEM-196 ARO:3001376 TEM-196 TEM-200 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001377 TEM-200 ARO:3001377 TEM-201 is a beta-lactamase found in Enterobacteriaceae. TEM-201 antibiotic_resistance ARO:3001378 TEM-201 ARO:3001378 TEM-201 is a beta-lactamase found in Enterobacteriaceae. PMID:24701189 TEM-201 TEM-202 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001379 TEM-202 ARO:3001379 TEM-203 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001380 TEM-203 ARO:3001380 TEM-204 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001381 TEM-204 ARO:3001381 TEM-205 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. TEM-205 antibiotic_resistance ARO:3001382 TEM-205 ARO:3001382 TEM-205 TEM-206 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. TEM-206 antibiotic_resistance ARO:3001383 TEM-206 ARO:3001383 TEM-206 TEM-207 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. TEM-207 antibiotic_resistance ARO:3001384 TEM-207 ARO:3001384 TEM-207 TEM-208 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. TEM-208 antibiotic_resistance ARO:3001385 TEM-208 ARO:3001385 TEM-208 TEM-209 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. TEM-209 antibiotic_resistance ARO:3001386 TEM-209 ARO:3001386 TEM-209 TEM-210. TEM-210 antibiotic_resistance ARO:3001387 TEM-210 ARO:3001387 TEM-210 TEM-211 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. TEM-211 antibiotic_resistance ARO:3001388 TEM-211 ARO:3001388 TEM-211 TEM-212 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. TEM-212 antibiotic_resistance ARO:3001389 TEM-212 ARO:3001389 TEM-212 TEM-213 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. TEM-213 antibiotic_resistance ARO:3001390 TEM-213 ARO:3001390 TEM-213 TEM-214 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. TEM-214 antibiotic_resistance ARO:3001391 TEM-214 ARO:3001391 TEM-214 TEM-215 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. TEM-215 antibiotic_resistance ARO:3001392 TEM-215 ARO:3001392 TEM-215 TEM-216 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. TEM-216 antibiotic_resistance ARO:3001393 TEM-216 ARO:3001393 TEM-216 TEM-217 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. TEM-217 antibiotic_resistance ARO:3001394 TEM-217 ARO:3001394 TEM-217 TEM-218 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001395 TEM-218 ARO:3001395 OXA-1 is a beta-lactamase found in E. coli. OXA-1 OXA-30 antibiotic_resistance ARO:3001396 OXA-1 ARO:3001396 OXA-1 is a beta-lactamase found in E. coli. PMID:2823258 PMID:33416461 OXA-1 OXA-2 is a beta-lactamase found in the Enterobacteriaceae family. OXA-2 antibiotic_resistance ARO:3001397 OXA-2 ARO:3001397 OXA-2 is a beta-lactamase found in the Enterobacteriaceae family. PMID:27499434 PMID:6335398 OXA-2 OXA-3 is a beta-lactamase found in P. aeruginosa. OXA-3 antibiotic_resistance ARO:3001398 OXA-3 ARO:3001398 OXA-3 is a beta-lactamase found in P. aeruginosa. PMID:7785990 OXA-3 OXA-4 is a beta-lactamase found in Enterobacteriaceae and P. aeruginosa. OXA-4 antibiotic_resistance ARO:3001399 OXA-4 ARO:3001399 OXA-4 is a beta-lactamase found in Enterobacteriaceae and P. aeruginosa. PMID:24426128 OXA-4 OXA-5 is a beta-lactamase found in P. aeruginosa and Enterobacteriaceae. OXA-5 antibiotic_resistance ARO:3001400 OXA-5 ARO:3001400 OXA-5 is a beta-lactamase found in P. aeruginosa and Enterobacteriaceae. PMID:3925874 OXA-5 The beta-lactamase name OXA-6 has been depreciated. antibiotic_resistance ARO:3001401 OXA-6 ARO:3001401 OXA-7 is a beta-lactamase found in P. aeruginosa and Enterobacteriaceae. OXA-7 antibiotic_resistance ARO:3001402 OXA-7 ARO:3001402 OXA-7 is a beta-lactamase found in P. aeruginosa and Enterobacteriaceae. PMID:3925874 OXA-7 The beta-lactamase name OXA-8 has been depreciated. antibiotic_resistance ARO:3001403 OXA-8 ARO:3001403 OXA-9 is a beta-lactamase found in Klebsiella pneumoniae. OXA-9 antibiotic_resistance ARO:3001404 OXA-9 ARO:3001404 OXA-9 is a beta-lactamase found in Klebsiella pneumoniae. PMID:9620445 OXA-9 OXA-10 is a beta-lactamase found in Acinetobacter baumannii and P. aeruginosa. OXA-10 PSE-2 antibiotic_resistance ARO:3001405 OXA-10 ARO:3001405 OXA-10 is a beta-lactamase found in Acinetobacter baumannii and P. aeruginosa. PMID:11017203 PMID:27499434 OXA-10 OXA-11 is a beta-lactamase found in P. aeruginosa. OXA-11 antibiotic_resistance ARO:3001406 OXA-11 ARO:3001406 OXA-11 is a beta-lactamase found in P. aeruginosa. PMID:8215276 OXA-11 OXA-12 is a beta-lactamase found in Aeromonas jandaei. AsbB1 OXA-12 antibiotic_resistance ARO:3001407 OXA-12 ARO:3001407 OXA-12 is a beta-lactamase found in Aeromonas jandaei. PMID:9068648 OXA-12 OXA-13 is a beta-lactamase found in P. aeruginosa. OXA-13 antibiotic_resistance ARO:3001408 OXA-13 ARO:3001408 OXA-13 is a beta-lactamase found in P. aeruginosa. PMID:9579076 OXA-13 OXA-14 is a beta-lactamase found in P. aeruginosa. OXA-14 antibiotic_resistance ARO:3001409 OXA-14 ARO:3001409 OXA-14 is a beta-lactamase found in P. aeruginosa. PMID:7486940 OXA-14 OXA-15 is a beta-lactamase found in P. aeruginosa. OXA-15 antibiotic_resistance ARO:3001410 OXA-15 ARO:3001410 OXA-15 is a beta-lactamase found in P. aeruginosa. PMID:9087490 OXA-15 OXA-16 is a beta-lactamase found in P. aeruginosa. OXA-16 antibiotic_resistance ARO:3001411 OXA-16 ARO:3001411 OXA-16 is a beta-lactamase found in P. aeruginosa. PMID:9835501 OXA-16 OXA-17 is a beta-lactamase found in P. aeruginosa and Klebsiella pneumoniae. OXA-17 antibiotic_resistance ARO:3001412 OXA-17 ARO:3001412 OXA-17 is a beta-lactamase found in P. aeruginosa and Klebsiella pneumoniae. PMID:10348753 OXA-17 OXA-18 is a beta-lactamase found in P. aeruginosa and Rickettsia. OXA-18 antibiotic_resistance ARO:3001413 OXA-18 ARO:3001413 OXA-18 is a beta-lactamase found in P. aeruginosa and Rickettsia. PMID:9333046 OXA-18 OXA-19 is a beta-lactamase found in P. aeruginosa. OXA-19 intl1 antibiotic_resistance ARO:3001414 OXA-19 ARO:3001414 OXA-19 is a beta-lactamase found in P. aeruginosa. PMID:9835500 OXA-19 OXA-20 is a beta-lactamase found in P. aeruginosa. OXA-20 antibiotic_resistance ARO:3001415 OXA-20 ARO:3001415 OXA-20 is a beta-lactamase found in P. aeruginosa. PMID:9687410 OXA-20 OXA-21 is a beta-lactamase found in A. baumannii. OXA-21 antibiotic_resistance ARO:3001416 OXA-21 ARO:3001416 OXA-21 is a beta-lactamase found in A. baumannii. PMID:9420053 OXA-21 OXA-22 is a beta-lactamase found in Ralstonia pickettii. OXA-22 antibiotic_resistance ARO:3001417 OXA-22 ARO:3001417 OXA-22 is a beta-lactamase found in Ralstonia pickettii. PMID:10898703 OXA-22 OXA-23 is a beta-lactamase found in A. baumannii. ARI-1 OXA-23 antibiotic_resistance ARO:3001418 OXA-23 ARO:3001418 OXA-23 is a beta-lactamase found in A. baumannii. PMID:10602749 OXA-23 OXA-24 is a beta-lactamase found in A. baumannii and P. aeruginosa. OXA-24 OXA-40 antibiotic_resistance ARO:3001419 OXA-24 ARO:3001419 OXA-24 is a beta-lactamase found in A. baumannii and P. aeruginosa. PMID:10817708 PMID:18585868 OXA-24 OXA-25 is a beta-lactamase found in A. baumannii. OXA-25 antibiotic_resistance ARO:3001420 OXA-25 ARO:3001420 OXA-25 is a beta-lactamase found in A. baumannii. PMID:11158758 OXA-25 OXA-26 is a beta-lactamase found in A. baumannii. OXA-26 antibiotic_resistance ARO:3001421 OXA-26 ARO:3001421 OXA-26 is a beta-lactamase found in A. baumannii. PMID:11158758 OXA-26 OXA-27 is a beta-lactamase found in A. baumannii. OXA-27 antibiotic_resistance ARO:3001422 OXA-27 ARO:3001422 OXA-27 is a beta-lactamase found in A. baumannii. PMID:11158758 OXA-27 OXA-28 is a beta-lactamase found in P. aeruginosa. OXA-28 antibiotic_resistance ARO:3001423 OXA-28 ARO:3001423 OXA-28 is a beta-lactamase found in P. aeruginosa. PMID:11158739 OXA-28 OXA-29 is a beta-lactamase found in Legionella gormanii. OXA-29 antibiotic_resistance ARO:3001424 OXA-29 ARO:3001424 OXA-29 is a beta-lactamase found in Legionella gormanii. PMID:11709332 OXA-29 OXA-31 is a beta-lactamase found in P. aeruginosa. OXA-31 antibiotic_resistance ARO:3001425 OXA-31 ARO:3001425 OXA-31 is a beta-lactamase found in P. aeruginosa. PMID:11353602 OXA-31 OXA-32 is a beta-lactamase found in P. aeruginosa. OXA-32 antibiotic_resistance ARO:3001426 OXA-32 ARO:3001426 OXA-32 is a beta-lactamase found in P. aeruginosa. PMID:11796380 OXA-32 OXA-33 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-33 antibiotic_resistance ARO:3001427 OXA-33 ARO:3001427 OXA-33 OXA-34 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-34 antibiotic_resistance ARO:3001428 OXA-34 ARO:3001428 OXA-34 OXA-35 is a beta-lactamase found in P. aeruginosa. OXA-35 antibiotic_resistance ARO:3001429 OXA-35 ARO:3001429 OXA-35 is a beta-lactamase found in P. aeruginosa. PMID:11679562 OXA-35 OXA-36 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-36 antibiotic_resistance ARO:3001430 OXA-36 ARO:3001430 OXA-36 OXA-37 is a beta-lactamase found in A. baumannii. OXA-37 antibiotic_resistance ARO:3001431 OXA-37 ARO:3001431 OXA-37 is a beta-lactamase found in A. baumannii. PMID:12523622 OXA-37 OXA-38 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001432 OXA-38 ARO:3001432 OXA-39 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001433 OXA-39 ARO:3001433 OXA-41 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001434 OXA-41 ARO:3001434 OXA-44 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001435 OXA-44 ARO:3001435 OXA-52 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001436 OXA-52 ARO:3001436 OXA-67 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-67 antibiotic_resistance ARO:3001437 OXA-67 ARO:3001437 OXA-67 OXA-100 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-100 antibiotic_resistance ARO:3001438 OXA-100 ARO:3001438 OXA-100 OXA-101 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-101 antibiotic_resistance ARO:3001439 OXA-101 ARO:3001439 OXA-101 OXA-115 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-115 antibiotic_resistance ARO:3001440 OXA-115 ARO:3001440 OXA-115 OXA-116 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-116 antibiotic_resistance ARO:3001441 OXA-116 ARO:3001441 OXA-116 OXA-117 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-117 antibiotic_resistance ARO:3001442 OXA-117 ARO:3001442 OXA-117 OXA-121 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-121 antibiotic_resistance ARO:3001443 OXA-121 ARO:3001443 OXA-121 OXA-122 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-122 antibiotic_resistance ARO:3001444 OXA-122 ARO:3001444 OXA-122 OXA-123 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-123 antibiotic_resistance ARO:3001445 OXA-123 ARO:3001445 OXA-123 OXA-124 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-124 antibiotic_resistance ARO:3001446 OXA-124 ARO:3001446 OXA-124 OXA-125 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-125 antibiotic_resistance ARO:3001447 OXA-125 ARO:3001447 OXA-125 OXA-126 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-126 antibiotic_resistance ARO:3001448 OXA-126 ARO:3001448 OXA-126 OXA-127 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-127 antibiotic_resistance ARO:3001449 OXA-127 ARO:3001449 OXA-127 OXA-139 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-139 antibiotic_resistance ARO:3001451 OXA-139 ARO:3001451 OXA-139 OXA-140 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-140 antibiotic_resistance ARO:3001452 OXA-140 ARO:3001452 OXA-140 OXA-148 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-148 antibiotic_resistance ARO:3001453 OXA-148 ARO:3001453 OXA-148 OXA-149 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-149 antibiotic_resistance ARO:3001454 OXA-149 ARO:3001454 OXA-149 OXA-150 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-150 antibiotic_resistance ARO:3001455 OXA-150 ARO:3001455 OXA-150 OXA-151 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-135 OXA-151 antibiotic_resistance ARO:3001456 OXA-151 ARO:3001456 OXA-151 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. PMID:26349828 OXA-151 OXA-152 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-152 antibiotic_resistance ARO:3001457 OXA-152 ARO:3001457 OXA-152 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. PMID:26349828 OXA-152 OXA-153 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-153 antibiotic_resistance ARO:3001458 OXA-153 ARO:3001458 OXA-153 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. PMID:26349828 OXA-153 OXA-154 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-154 antibiotic_resistance ARO:3001459 OXA-154 ARO:3001459 OXA-154 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. PMID:26349828 OXA-154 OXA-155 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-155 antibiotic_resistance ARO:3001460 OXA-155 ARO:3001460 OXA-155 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. PMID:26349828 OXA-155 OXA-156 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-156 antibiotic_resistance ARO:3001461 OXA-156 ARO:3001461 OXA-156 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. PMID:26349828 OXA-156 OXA-157 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-157 antibiotic_resistance ARO:3001462 OXA-157 ARO:3001462 OXA-157 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. PMID:26349828 OXA-157 OXA-158 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-158 antibiotic_resistance ARO:3001463 OXA-158 ARO:3001463 OXA-158 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. PMID:26349828 OXA-158 OXA-159 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-159 antibiotic_resistance ARO:3001464 OXA-159 ARO:3001464 OXA-159 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. PMID:26349828 OXA-159 OXA-165 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-165 antibiotic_resistance ARO:3001465 OXA-165 ARO:3001465 OXA-165 OXA-166 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-166 antibiotic_resistance ARO:3001466 OXA-166 ARO:3001466 OXA-166 OXA-167 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-167 antibiotic_resistance ARO:3001467 OXA-167 ARO:3001467 OXA-167 OXA-168 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-168 antibiotic_resistance ARO:3001468 OXA-168 ARO:3001468 OXA-168 OXA-169 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-169 antibiotic_resistance ARO:3001469 OXA-169 ARO:3001469 OXA-169 OXA-170 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-170 antibiotic_resistance ARO:3001470 OXA-170 ARO:3001470 OXA-170 OXA-171 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-171 antibiotic_resistance ARO:3001471 OXA-171 ARO:3001471 OXA-171 OXA-178 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-178 antibiotic_resistance ARO:3001472 OXA-178 ARO:3001472 OXA-178 OXA-179 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-179 antibiotic_resistance ARO:3001473 OXA-179 ARO:3001473 OXA-179 OXA-180 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-180 antibiotic_resistance ARO:3001474 OXA-180 ARO:3001474 OXA-180 OXA-183 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-183 antibiotic_resistance ARO:3001475 OXA-183 ARO:3001475 OXA-183 OXA-184 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-184 antibiotic_resistance ARO:3001476 OXA-184 ARO:3001476 OXA-184 OXA-185 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-185 antibiotic_resistance ARO:3001477 OXA-185 ARO:3001477 OXA-185 OXA-193 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-193 antibiotic_resistance ARO:3001478 OXA-193 ARO:3001478 OXA-193 OXA-194 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-194 antibiotic_resistance ARO:3001479 OXA-194 ARO:3001479 OXA-194 OXA-195 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-195 antibiotic_resistance ARO:3001480 OXA-195 ARO:3001480 OXA-195 OXA-196 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-196 antibiotic_resistance ARO:3001481 OXA-196 ARO:3001481 OXA-196 OXA-197 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-197 antibiotic_resistance ARO:3001482 OXA-197 ARO:3001482 OXA-197 OXA-205 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-205 antibiotic_resistance ARO:3001483 OXA-205 ARO:3001483 OXA-205 OXA-206 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-206 antibiotic_resistance ARO:3001484 OXA-206 ARO:3001484 OXA-206 OXA-207 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-207 antibiotic_resistance ARO:3001485 OXA-207 ARO:3001485 OXA-207 OXA-208 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-208 antibiotic_resistance ARO:3001486 OXA-208 ARO:3001486 OXA-208 OXA-210 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-210 antibiotic_resistance ARO:3001487 OXA-210 ARO:3001487 OXA-210 OXA-216 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-216 antibiotic_resistance ARO:3001488 OXA-216 ARO:3001488 OXA-216 OXA-217 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-217 antibiotic_resistance ARO:3001489 OXA-217 ARO:3001489 OXA-217 OXA-220 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001490 OXA-220 ARO:3001490 OXA-221 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001491 OXA-221 ARO:3001491 OXA-222 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001492 OXA-222 ARO:3001492 OXA-225 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-225 antibiotic_resistance ARO:3001493 OXA-225 ARO:3001493 OXA-225 OXA-227 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001494 OXA-227 ARO:3001494 OXA-233 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-233 antibiotic_resistance ARO:3001495 OXA-233 ARO:3001495 OXA-233 OXA-234 is a beta-lactamase found in Acinetobacter baumannii. OXA-234 antibiotic_resistance ARO:3001496 OXA-234 ARO:3001496 OXA-234 OXA-238 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001497 OXA-238 ARO:3001497 OXA-239 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-239 antibiotic_resistance ARO:3001498 OXA-239 ARO:3001498 OXA-239 OXA-240 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-240 antibiotic_resistance ARO:3001499 OXA-240 ARO:3001499 OXA-240 OXA-251 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-251 antibiotic_resistance ARO:3001500 OXA-251 ARO:3001500 OXA-251 OXA-252 is a beta-lactamase found in Shewanella spp. OXA-252 antibiotic_resistance ARO:3001501 OXA-252 ARO:3001501 OXA-252 OXA-256 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-256 antibiotic_resistance ARO:3001502 OXA-256 ARO:3001502 OXA-256 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. PMID:23458448 OXA-256 OXA-258 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-258 antibiotic_resistance ARO:3001503 OXA-258 ARO:3001503 OXA-258 OXA-309 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-309 antibiotic_resistance ARO:3001504 OXA-309 ARO:3001504 OXA-309 OXA-310 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001505 OXA-310 ARO:3001505 OXA-311 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001506 OXA-311 ARO:3001506 OXA-318 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001507 OXA-318 ARO:3001507 OXA-319 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001508 OXA-319 ARO:3001508 OXA-321 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001509 OXA-321 ARO:3001509 OXA-322 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-322 antibiotic_resistance ARO:3001510 OXA-322 ARO:3001510 OXA-322 OXA-323 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-323 antibiotic_resistance ARO:3001511 OXA-323 ARO:3001511 OXA-323 OXA-324 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-324 antibiotic_resistance ARO:3001512 OXA-324 ARO:3001512 OXA-324 OXA-325 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-325 antibiotic_resistance ARO:3001513 OXA-325 ARO:3001513 OXA-325 OXA-326 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-326 antibiotic_resistance ARO:3001514 OXA-326 ARO:3001514 OXA-326 OXA-327 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-327 antibiotic_resistance ARO:3001515 OXA-327 ARO:3001515 OXA-327 OXA-328 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-328 antibiotic_resistance ARO:3001516 OXA-328 ARO:3001516 OXA-328 OXA-329 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-329 antibiotic_resistance ARO:3001517 OXA-329 ARO:3001517 OXA-329 OXA-330 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-330 antibiotic_resistance ARO:3001518 OXA-330 ARO:3001518 OXA-330 OXA-331 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-331 antibiotic_resistance ARO:3001519 OXA-331 ARO:3001519 OXA-331 OXA-332 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-332 antibiotic_resistance ARO:3001520 OXA-332 ARO:3001520 OXA-332 OXA-333 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-333 antibiotic_resistance ARO:3001521 OXA-333 ARO:3001521 OXA-333 OXA-334 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-334 antibiotic_resistance ARO:3001522 OXA-334 ARO:3001522 OXA-334 OXA-335 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-335 antibiotic_resistance ARO:3001523 OXA-335 ARO:3001523 OXA-335 OXA-336 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-336 antibiotic_resistance ARO:3001524 OXA-336 ARO:3001524 OXA-336 OXA-337 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-337 antibiotic_resistance ARO:3001525 OXA-337 ARO:3001525 OXA-337 OXA-338 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-338 antibiotic_resistance ARO:3001526 OXA-338 ARO:3001526 OXA-338 OXA-339 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-339 antibiotic_resistance ARO:3001527 OXA-339 ARO:3001527 OXA-339 OXA-340 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-340 antibiotic_resistance ARO:3001528 OXA-340 ARO:3001528 OXA-340 OXA-341 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-341 antibiotic_resistance ARO:3001529 OXA-341 ARO:3001529 OXA-341 OXA-342 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-342 antibiotic_resistance ARO:3001530 OXA-342 ARO:3001530 OXA-342 OXA-343 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-343 antibiotic_resistance ARO:3001531 OXA-343 ARO:3001531 OXA-343 OXA-344 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-344 antibiotic_resistance ARO:3001532 OXA-344 ARO:3001532 OXA-344 OXA-345 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-345 antibiotic_resistance ARO:3001533 OXA-345 ARO:3001533 OXA-345 OXA-346 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-346 antibiotic_resistance ARO:3001534 OXA-346 ARO:3001534 OXA-346 OXA-348 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-348 antibiotic_resistance ARO:3001535 OXA-348 ARO:3001535 OXA-348 OXA-349 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-349 antibiotic_resistance ARO:3001536 OXA-349 ARO:3001536 OXA-349 OXA-350 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-350 antibiotic_resistance ARO:3001537 OXA-350 ARO:3001537 OXA-350 OXA-351 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-351 antibiotic_resistance ARO:3001538 OXA-351 ARO:3001538 OXA-351 OXA-352 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-352 antibiotic_resistance ARO:3001539 OXA-352 ARO:3001539 OXA-352 OXA-353 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-353 antibiotic_resistance ARO:3001540 OXA-353 ARO:3001540 OXA-353 OXA-354 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-354 antibiotic_resistance ARO:3001541 OXA-354 ARO:3001541 OXA-354 OXA-355 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-355 antibiotic_resistance ARO:3001542 OXA-355 ARO:3001542 OXA-355 OXA-356 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-356 antibiotic_resistance ARO:3001543 OXA-356 ARO:3001543 OXA-356 OXA-357 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-357 antibiotic_resistance ARO:3001544 OXA-357 ARO:3001544 OXA-357 OXA-358 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-358 antibiotic_resistance ARO:3001545 OXA-358 ARO:3001545 OXA-358 OXA-359 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-359 antibiotic_resistance ARO:3001546 OXA-359 ARO:3001546 OXA-359 OXA-360 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-360 antibiotic_resistance ARO:3001547 OXA-360 ARO:3001547 OXA-360 OXA-361 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-361 antibiotic_resistance ARO:3001548 OXA-361 ARO:3001548 OXA-361 OXA-362 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-362 antibiotic_resistance ARO:3001549 OXA-362 ARO:3001549 OXA-362 OXA-363 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-363 antibiotic_resistance ARO:3001550 OXA-363 ARO:3001550 OXA-363 OXA-364 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-364 antibiotic_resistance ARO:3001551 OXA-364 ARO:3001551 OXA-364 OXA-365 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-365 antibiotic_resistance ARO:3001552 OXA-365 ARO:3001552 OXA-365 OXA-366 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-366 antibiotic_resistance ARO:3001553 OXA-366 ARO:3001553 OXA-366 OXA-367 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001554 OXA-367 ARO:3001554 OXA-368 is a beta-lactamase found in Aeromonas sobria. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-368 antibiotic_resistance ARO:3001555 OXA-368 ARO:3001555 OXA-368 is a beta-lactamase found in Aeromonas sobria. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. PMID:27499434 OXA-368 OXA-371 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-371 antibiotic_resistance ARO:3001557 OXA-371 ARO:3001557 OXA-371 OXA-372 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-372 antibiotic_resistance ARO:3001558 OXA-372 ARO:3001558 OXA-372 OXA-373 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-373 antibiotic_resistance ARO:3001559 OXA-373 ARO:3001559 OXA-373 OXA-374 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-374 antibiotic_resistance ARO:3001560 OXA-374 ARO:3001560 OXA-374 OXA-375 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-375 antibiotic_resistance ARO:3001561 OXA-375 ARO:3001561 OXA-375 OXA-376 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-376 antibiotic_resistance ARO:3001562 OXA-376 ARO:3001562 OXA-376 OXA-377 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-377 antibiotic_resistance ARO:3001563 OXA-377 ARO:3001563 OXA-377 OXA-378 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-378 antibiotic_resistance ARO:3001564 OXA-378 ARO:3001564 OXA-378 OXA-379 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-379 antibiotic_resistance ARO:3001565 OXA-379 ARO:3001565 OXA-379 OXA-380 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-380 antibiotic_resistance ARO:3001566 OXA-380 ARO:3001566 OXA-380 OXA-381 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-381 antibiotic_resistance ARO:3001567 OXA-381 ARO:3001567 OXA-381 OXA-382 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-382 antibiotic_resistance ARO:3001568 OXA-382 ARO:3001568 OXA-382 OXA-383 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-383 antibiotic_resistance ARO:3001569 OXA-383 ARO:3001569 OXA-383 OXA-384 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-384 antibiotic_resistance ARO:3001570 OXA-384 ARO:3001570 OXA-384 OXA-385 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-385 antibiotic_resistance ARO:3001571 OXA-385 ARO:3001571 OXA-385 OXA-386 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-386 antibiotic_resistance ARO:3001572 OXA-386 ARO:3001572 OXA-386 OXA-387 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-387 antibiotic_resistance ARO:3001573 OXA-387 ARO:3001573 OXA-387 OXA-388 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-388 antibiotic_resistance ARO:3001574 OXA-388 ARO:3001574 OXA-388 OXA-389 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-389 antibiotic_resistance ARO:3001575 OXA-389 ARO:3001575 OXA-389 OXA-390 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-390 antibiotic_resistance ARO:3001576 OXA-390 ARO:3001576 OXA-390 OXA-391 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-391 antibiotic_resistance ARO:3001577 OXA-391 ARO:3001577 OXA-391 OXA-392 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-392 antibiotic_resistance ARO:3001578 OXA-392 ARO:3001578 OXA-392 OXA-393 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001579 OXA-393 ARO:3001579 OXA-394 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001580 OXA-394 ARO:3001580 OXA-395 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-395 antibiotic_resistance ARO:3001581 OXA-395 ARO:3001581 OXA-395 OXA-396 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-396 antibiotic_resistance ARO:3001582 OXA-396 ARO:3001582 OXA-396 OXA-397 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-397 antibiotic_resistance ARO:3001583 OXA-397 ARO:3001583 OXA-397 OXA-398 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-398 antibiotic_resistance ARO:3001584 OXA-398 ARO:3001584 OXA-398 OXA-399 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001585 OXA-399 ARO:3001585 OXA-400 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-400 antibiotic_resistance ARO:3001586 OXA-400 ARO:3001586 OXA-400 OXA-401 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-401 antibiotic_resistance ARO:3001587 OXA-401 ARO:3001587 OXA-401 OXA-402 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-402 antibiotic_resistance ARO:3001588 OXA-402 ARO:3001588 OXA-402 OXA-403 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-403 antibiotic_resistance ARO:3001589 OXA-403 ARO:3001589 OXA-403 OXA-404 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-404 antibiotic_resistance ARO:3001595 OXA-404 ARO:3001595 OXA-404 OXA-405 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-405 antibiotic_resistance ARO:3001596 OXA-405 ARO:3001596 OXA-405 OXA-406 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-406 antibiotic_resistance ARO:3001597 OXA-406 ARO:3001597 OXA-406 OXA-407 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-407 antibiotic_resistance ARO:3001598 OXA-407 ARO:3001598 OXA-407 OXA-408 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-408 antibiotic_resistance ARO:3001599 OXA-408 ARO:3001599 OXA-408 OXA-409 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-409 antibiotic_resistance ARO:3001600 OXA-409 ARO:3001600 OXA-409 OXA-410 is an OXA-51-like beta-lactamase. OXA-410 antibiotic_resistance ARO:3001601 OXA-410 ARO:3001601 OXA-410 OXA-411 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-411 antibiotic_resistance ARO:3001602 OXA-411 ARO:3001602 OXA-411 OXA-412 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-412 antibiotic_resistance ARO:3001603 OXA-412 ARO:3001603 OXA-412 OXA-413 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-413 antibiotic_resistance ARO:3001604 OXA-413 ARO:3001604 OXA-413 OXA-414 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-414 antibiotic_resistance ARO:3001605 OXA-414 ARO:3001605 OXA-414 OXA-415 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-415 antibiotic_resistance ARO:3001606 OXA-415 ARO:3001606 OXA-415 OXA-416 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-416 antibiotic_resistance ARO:3001607 OXA-416 ARO:3001607 OXA-416 OXA-417 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-417 antibiotic_resistance ARO:3001608 OXA-417 ARO:3001608 OXA-417 OXA-114a is a beta-lactamase found in Achromobacter xylosoxidans. OXA-114a antibiotic_resistance ARO:3001609 OXA-114a ARO:3001609 OXA-114a is a beta-lactamase found in Achromobacter xylosoxidans. PMID:18362192 OXA-114a OXA-243 is a beta-lactamase found in Achromobacter xylosoxidans. OXA-243 antibiotic_resistance ARO:3001610 OXA-243 ARO:3001610 OXA-243 is a beta-lactamase found in Achromobacter xylosoxidans. PMID:22944724 OXA-243 OXA-58 is a beta-lactamase found in A. baumannii. OXA-58 antibiotic_resistance ARO:3001611 OXA-58 ARO:3001611 OXA-58 is a beta-lactamase found in A. baumannii. PMID:15616297 OXA-58 OXA-51 is a beta-lactamase found in A. baumannii. OXA-51 antibiotic_resistance ARO:3001612 OXA-51 ARO:3001612 OXA-51 is a beta-lactamase found in A. baumannii. PMID:15649299 OXA-51 OXA-64 is a beta-lactamase found in A. baumannii. OXA-64 antibiotic_resistance ARO:3001613 OXA-64 ARO:3001613 OXA-64 is a beta-lactamase found in A. baumannii. PMID:15760431 OXA-64 OXA-65 is a beta-lactamase found in A. baumannii. OXA-65 antibiotic_resistance ARO:3001614 OXA-65 ARO:3001614 OXA-65 is a beta-lactamase found in A. baumannii. PMID:15760431 OXA-65 OXA-66 is a beta-lactamase found in A. baumannii. OXA-66 antibiotic_resistance ARO:3001615 OXA-66 ARO:3001615 OXA-66 is a beta-lactamase found in A. baumannii. PMID:15760431 OXA-66 OXA-68 is a beta-lactamase found in A. baumannii. OXA-68 antibiotic_resistance ARO:3001616 OXA-68 ARO:3001616 OXA-68 is a beta-lactamase found in A. baumannii. PMID:15760431 OXA-68 OXA-69 is a beta-lactamase found in A. baumannii. OXA-69 antibiotic_resistance ARO:3001617 OXA-69 ARO:3001617 OXA-69 is a beta-lactamase found in A. baumannii. PMID:15760431 OXA-69 OXA-70 is a beta-lactamase found in A. baumannii. OXA-70 antibiotic_resistance ARO:3001618 OXA-70 ARO:3001618 OXA-70 is a beta-lactamase found in A. baumannii. PMID:15760431 OXA-70 OXA-71 is a beta-lactamase found in A. baumannii. OXA-71 antibiotic_resistance ARO:3001619 OXA-71 ARO:3001619 OXA-71 is a beta-lactamase found in A. baumannii. PMID:15760431 OXA-71 OXA-75 is a beta-lactamase found in A. baumannii. OXA-75 antibiotic_resistance ARO:3001620 OXA-75 ARO:3001620 OXA-75 is a beta-lactamase found in A. baumannii. PMID:16189095 OXA-75 OXA-76 is a beta-lactamase found in A. baumannii. OXA-76 antibiotic_resistance ARO:3001621 OXA-76 ARO:3001621 OXA-76 is a beta-lactamase found in A. baumannii. PMID:16189095 OXA-76 OXA-77 is a beta-lactamase found in A. baumannii. OXA-77 antibiotic_resistance ARO:3001622 OXA-77 ARO:3001622 OXA-77 is a beta-lactamase found in A. baumannii. PMID:16189095 OXA-77 OXA-83 is a beta-lactamase found in A. baumannii. OXA-83 antibiotic_resistance ARO:3001623 OXA-83 ARO:3001623 OXA-83 is a beta-lactamase found in A. baumannii. PMID:16630258 OXA-83 OXA-84 is a beta-lactamase found in A. baumannii. OXA-84 antibiotic_resistance ARO:3001624 OXA-84 ARO:3001624 OXA-84 is a beta-lactamase found in A. baumannii. PMID:16630258 OXA-84 OXA-89 is a beta-lactamase found in A. baumannii. OXA-89 antibiotic_resistance ARO:3001625 OXA-89 ARO:3001625 OXA-89 is a beta-lactamase found in A. baumannii. PMID:16844350 OXA-89 OXA-88 is a beta-lactamase found in A. baumannii. OXA-88 antibiotic_resistance ARO:3001626 OXA-88 ARO:3001626 OXA-88 is a beta-lactamase found in A. baumannii. PMID:17284537 OXA-88 OXA-91 is a beta-lactamase found in A. baumannii. OXA-91 antibiotic_resistance ARO:3001627 OXA-91 ARO:3001627 OXA-91 is a beta-lactamase found in A. baumannii. PMID:17284537 OXA-91 OXA-93 is a beta-lactamase found in A. baumannii. OXA-93 antibiotic_resistance ARO:3001628 OXA-93 ARO:3001628 OXA-93 is a beta-lactamase found in A. baumannii. PMID:17284537 OXA-93 OXA-94 is a beta-lactamase found in A. baumannii. OXA-94 antibiotic_resistance ARO:3001629 OXA-94 ARO:3001629 OXA-94 is a beta-lactamase found in A. baumannii. PMID:17284537 OXA-94 OXA-95 is a beta-lactamase found in A. baumannii. OXA-95 antibiotic_resistance ARO:3001630 OXA-95 ARO:3001630 OXA-95 is a beta-lactamase found in A. baumannii. PMID:17284537 OXA-95 OXA-96 is a beta-lactamase found in A. baumannii. OXA-96 antibiotic_resistance ARO:3001631 OXA-96 ARO:3001631 OXA-96 is a beta-lactamase found in A. baumannii. PMID:17284537 OXA-96 OXA-92 is a beta-lactamase found in A. baumannii. OXA-92 antibiotic_resistance ARO:3001632 OXA-92 ARO:3001632 OXA-92 is a beta-lactamase found in A. baumannii. PMID:17391399 OXA-92 OXA-79 is a beta-lactamase found in A. baumannii. OXA-79 antibiotic_resistance ARO:3001633 OXA-79 ARO:3001633 OXA-79 is a beta-lactamase found in A. baumannii. PMID:17391399 OXA-79 OXA-80 is a beta-lactamase found in A. baumannii. OXA-80 antibiotic_resistance ARO:3001634 OXA-80 ARO:3001634 OXA-80 is a beta-lactamase found in A. baumannii. PMID:17391399 OXA-80 OXA-82 is a beta-lactamase found in A. baumannii. OXA-82 antibiotic_resistance ARO:3001635 OXA-82 ARO:3001635 OXA-82 is a beta-lactamase found in A. baumannii. PMID:17391399 OXA-82 OXA-104 is a beta-lactamase found in A. baumannii. OXA-104 antibiotic_resistance ARO:3001636 OXA-104 ARO:3001636 OXA-104 is a beta-lactamase found in A. baumannii. PMID:17391399 OXA-104 OXA-106 is a beta-lactamase found in A. baumannii. OXA-106 antibiotic_resistance ARO:3001637 OXA-106 ARO:3001637 OXA-106 is a beta-lactamase found in A. baumannii. PMID:17391399 OXA-106 OXA-107 is a beta-lactamase found in A. baumannii. OXA-107 antibiotic_resistance ARO:3001638 OXA-107 ARO:3001638 OXA-107 is a beta-lactamase found in A. baumannii. PMID:17391399 OXA-107 OXA-108 is a beta-lactamase found in A. baumannii. OXA-108 antibiotic_resistance ARO:3001639 OXA-108 ARO:3001639 OXA-108 is a beta-lactamase found in A. baumannii. PMID:17391399 OXA-108 OXA-109 is a beta-lactamase found in A. baumannii. OXA-109 antibiotic_resistance ARO:3001640 OXA-109 ARO:3001640 OXA-109 is a beta-lactamase found in A. baumannii. PMID:17391399 OXA-109 OXA-110 is a beta-lactamase found in A. baumannii. OXA-110 antibiotic_resistance ARO:3001641 OXA-110 ARO:3001641 OXA-110 is a beta-lactamase found in A. baumannii. PMID:17391399 OXA-110 OXA-111 is a beta-lactamase found in A. baumannii. OXA-111 antibiotic_resistance ARO:3001642 OXA-111 ARO:3001642 OXA-111 is a beta-lactamase found in A. baumannii. PMID:17391399 OXA-111 OXA-112 is a beta-lactamase found in A. baumannii. OXA-112 antibiotic_resistance ARO:3001643 OXA-112 ARO:3001643 OXA-112 is a beta-lactamase found in A. baumannii. PMID:17391399 OXA-112 OXA-113 is a beta-lactamase found in A. baumannii. OXA-113 antibiotic_resistance ARO:3001644 OXA-113 ARO:3001644 OXA-113 is a beta-lactamase found in A. baumannii. PMID:17881631 OXA-113 OXA-78 is a beta-lactamase found in A. baumannii. OXA-78 antibiotic_resistance ARO:3001645 OXA-78 ARO:3001645 OXA-78 is a beta-lactamase found in A. baumannii. PMID:18190566 OXA-78 OXA-98 is a beta-lactamase found in A. baumannii. OXA-98 antibiotic_resistance ARO:3001646 OXA-98 ARO:3001646 OXA-98 is a beta-lactamase found in A. baumannii. PMID:18190566 OXA-98 OXA-97 is a beta-lactamase found in A. baumannii. OXA-97 antibiotic_resistance ARO:3001647 OXA-97 ARO:3001647 OXA-97 is a beta-lactamase found in A. baumannii. PMID:18299404 OXA-97 OXA-128 is a beta-lactamase found in A. baumannii. OXA-128 antibiotic_resistance ARO:3001648 OXA-128 ARO:3001648 OXA-128 is a beta-lactamase found in A. baumannii. PMID:19223304 OXA-128 OXA-99 is a beta-lactamase found in A. baumannii. OXA-99 antibiotic_resistance ARO:3001649 OXA-99 ARO:3001649 OXA-99 is a beta-lactamase found in A. baumannii. PMID:19394202 OXA-99 OXA-90 is a beta-lactamase found in A. baumannii. OXA-90 antibiotic_resistance ARO:3001650 OXA-90 ARO:3001650 OXA-90 is a beta-lactamase found in A. baumannii. PMID:19567349 OXA-90 OXA-130 is a beta-lactamase found in A. baumannii. OXA-130 antibiotic_resistance ARO:3001651 OXA-130 ARO:3001651 OXA-130 is a beta-lactamase found in A. baumannii. PMID:19567349 OXA-130 OXA-131 is a beta-lactamase found in A. baumannii. OXA-131 antibiotic_resistance ARO:3001652 OXA-131 ARO:3001652 OXA-131 is a beta-lactamase found in A. baumannii. PMID:19567349 OXA-131 OXA-132 is a beta-lactamase found in A. baumannii. OXA-132 antibiotic_resistance ARO:3001653 OXA-132 ARO:3001653 OXA-132 is a beta-lactamase found in A. baumannii. PMID:19567349 OXA-132 OXA-143 is a beta-lactamase found in A. baumannii. OXA-143 antibiotic_resistance ARO:3001654 OXA-143 ARO:3001654 OXA-143 is a beta-lactamase found in A. baumannii. PMID:19770279 OXA-143 OXA-138 is a beta-lactamase found in A. baumannii. OXA-138 antibiotic_resistance ARO:3001655 OXA-138 ARO:3001655 OXA-138 is a beta-lactamase found in A. baumannii. PMID:20713680 OXA-138 OXA-172 is a beta-lactamase found in A. baumannii. OXA-172 antibiotic_resistance ARO:3001656 OXA-172 ARO:3001656 OXA-172 is a beta-lactamase found in A. baumannii. PMID:20713680 OXA-172 OXA-173 is a beta-lactamase found in A. baumannii. OXA-173 antibiotic_resistance ARO:3001657 OXA-173 ARO:3001657 OXA-173 is a beta-lactamase found in A. baumannii. PMID:20713680 OXA-173 OXA-174 is a beta-lactamase found in A. baumannii. OXA-174 antibiotic_resistance ARO:3001658 OXA-174 ARO:3001658 OXA-174 is a beta-lactamase found in A. baumannii. PMID:20713680 OXA-174 OXA-175 is a beta-lactamase found in A. baumannii. OXA-175 antibiotic_resistance ARO:3001659 OXA-175 ARO:3001659 OXA-175 is a beta-lactamase found in A. baumannii. PMID:20713680 OXA-175 OXA-176 is a beta-lactamase found in A. baumannii. OXA-176 antibiotic_resistance ARO:3001660 OXA-176 ARO:3001660 OXA-176 is a beta-lactamase found in A. baumannii. PMID:20713680 OXA-176 OXA-177 is a beta-lactamase found in A. baumannii. OXA-177 antibiotic_resistance ARO:3001661 OXA-177 ARO:3001661 OXA-177 is a beta-lactamase found in A. baumannii. PMID:20713680 OXA-177 OXA-164 is a beta-lactamase found in A. baumannii. OXA-164 antibiotic_resistance ARO:3001662 OXA-164 ARO:3001662 OXA-164 is a beta-lactamase found in A. baumannii. PMID:20921306 OXA-164 OXA-160 is a beta-lactamase found in A. baumannii. OXA-160 antibiotic_resistance ARO:3001663 OXA-160 ARO:3001663 OXA-160 is a beta-lactamase found in A. baumannii. PMID:21041501 OXA-160 OXA-203 is a beta-lactamase found in A. baumannii. OXA-203 antibiotic_resistance ARO:3001664 OXA-203 ARO:3001664 OXA-203 is a beta-lactamase found in A. baumannii. PMID:21289143 OXA-203 OXA-200 is a beta-lactamase found in A. baumannii. OXA-200 antibiotic_resistance ARO:3001665 OXA-200 ARO:3001665 OXA-200 is a beta-lactamase found in A. baumannii. PMID:22422849 OXA-200 OXA-201 is a beta-lactamase found in A. baumannii. OXA-201 antibiotic_resistance ARO:3001666 OXA-201 ARO:3001666 OXA-201 is a beta-lactamase found in A. baumannii. PMID:22422849 OXA-201 OXA-202 is a beta-lactamase found in A. baumannii. OXA-202 antibiotic_resistance ARO:3001667 OXA-202 ARO:3001667 OXA-202 is a beta-lactamase found in A. baumannii. PMID:22422849 OXA-202 OXA-219 is a beta-lactamase found in A. baumannii. OXA-219 antibiotic_resistance ARO:3001668 OXA-219 ARO:3001668 OXA-219 is a beta-lactamase found in A. baumannii. PMID:22422849 OXA-219 OXA-223 is a beta-lactamase found in A. baumannii. OXA-223 antibiotic_resistance ARO:3001669 OXA-223 ARO:3001669 OXA-223 is a beta-lactamase found in A. baumannii. PMID:22422849 OXA-223 OXA-231 is a beta-lactamase found in A. baumannii. OXA-231 antibiotic_resistance ARO:3001670 OXA-231 ARO:3001670 OXA-231 is a beta-lactamase found in A. baumannii. PMID:22736746 OXA-231 OXA-49 is a beta-lactamase found in A. baumannii. OXA-49 antibiotic_resistance ARO:3001671 OXA-49 ARO:3001671 OXA-49 is a beta-lactamase found in A. baumannii. PMID:22842601 OXA-49 OXA-120 is a beta-lactamase found in A. baumannii. OXA-120 antibiotic_resistance ARO:3001672 OXA-120 ARO:3001672 OXA-120 is a beta-lactamase found in A. baumannii. PMID:22972816 OXA-120 OXA-248 is a beta-lactamase found in A. baumannii. OXA-248 antibiotic_resistance ARO:3001673 OXA-248 ARO:3001673 OXA-248 is a beta-lactamase found in A. baumannii. PMID:22972816 OXA-248 OXA-249 is a beta-lactamase found in A. baumannii. OXA-249 antibiotic_resistance ARO:3001674 OXA-249 ARO:3001674 OXA-249 is a beta-lactamase found in A. baumannii. PMID:22972816 OXA-249 OXA-250 is a beta-lactamase found in A. baumannii. OXA-250 antibiotic_resistance ARO:3001675 OXA-250 ARO:3001675 OXA-250 is a beta-lactamase found in A. baumannii. PMID:22972816 OXA-250 OXA-235 is a beta-lactamase found in A. baumannii. OXA-235 antibiotic_resistance ARO:3001676 OXA-235 ARO:3001676 OXA-235 is a beta-lactamase found in A. baumannii. PMID:23439638 OXA-235 OXA-236 is a beta-lactamase found in A. baumannii. OXA-236 antibiotic_resistance ARO:3001677 OXA-236 ARO:3001677 OXA-236 is a beta-lactamase found in A. baumannii. PMID:23439638 OXA-236 OXA-237 is a beta-lactamase found in A. baumannii. OXA-237 antibiotic_resistance ARO:3001678 OXA-237 ARO:3001678 OXA-237 is a beta-lactamase found in A. baumannii. PMID:23439638 OXA-237 OXA-241 is a beta-lactamase found in A. baumannii. OXA-241 antibiotic_resistance ARO:3001679 OXA-241 ARO:3001679 OXA-241 is a beta-lactamase found in A. baumannii. PMID:23439638 OXA-241 OXA-242 is a beta-lactamase found in A. baumannii. OXA-242 antibiotic_resistance ARO:3001680 OXA-242 ARO:3001680 OXA-242 is a beta-lactamase found in A. baumannii. PMID:23439638 OXA-242 OXA-278 is a beta-lactamase found in A. baumannii. OXA-278 antibiotic_resistance ARO:3001681 OXA-278 ARO:3001681 OXA-278 is a beta-lactamase found in A. baumannii. PMID:23554204 OXA-278 OXA-254 is a beta-lactamase found in A. baumannii. OXA-254 antibiotic_resistance ARO:3001682 OXA-254 ARO:3001682 OXA-254 is a beta-lactamase found in A. baumannii. PMID:23719027 OXA-254 OXA-312 is a beta-lactamase found in A. baumannii. OXA-312 antibiotic_resistance ARO:3001683 OXA-312 ARO:3001683 OXA-312 is a beta-lactamase found in A. baumannii. PMID:24247131 OXA-312 OXA-313 is a beta-lactamase found in A. baumannii. OXA-313 antibiotic_resistance ARO:3001684 OXA-313 ARO:3001684 OXA-313 is a beta-lactamase found in A. baumannii. PMID:24247131 OXA-313 OXA-314 is a beta-lactamase found in A. baumannii. OXA-314 antibiotic_resistance ARO:3001685 OXA-314 ARO:3001685 OXA-314 is a beta-lactamase found in A. baumannii. PMID:24247131 OXA-314 OXA-315 is a beta-lactamase found in A. baumannii. OXA-315 antibiotic_resistance ARO:3001686 OXA-315 ARO:3001686 OXA-315 is a beta-lactamase found in A. baumannii. PMID:24247131 OXA-315 OXA-316 is a beta-lactamase found in A. baumannii. OXA-316 antibiotic_resistance ARO:3001687 OXA-316 ARO:3001687 OXA-316 is a beta-lactamase found in A. baumannii. PMID:24247131 OXA-316 OXA-317 is a beta-lactamase found in A. baumannii. OXA-317 antibiotic_resistance ARO:3001688 OXA-317 ARO:3001688 OXA-317 is a beta-lactamase found in A. baumannii. PMID:24247131 OXA-317 OXA-253 is a beta-lactamase found in A. baumannii. OXA-253 antibiotic_resistance ARO:3001689 OXA-253 ARO:3001689 OXA-253 is a beta-lactamase found in A. baumannii. PMID:24566181 OXA-253 OXA-255 is a beta-lactamase found in A. baumannii. OXA-255 antibiotic_resistance ARO:3001690 OXA-255 ARO:3001690 OXA-255 is a beta-lactamase found in A. baumannii. PMID:24566181 OXA-255 OXA-228 is a beta-lactamase found in A. bereziniae. OXA-228 antibiotic_resistance ARO:3001691 OXA-228 ARO:3001691 OXA-228 is a beta-lactamase found in A. bereziniae. PMID:22508298 OXA-228 OXA-229 is a beta-lactamase found in A. bereziniae. OXA-229 antibiotic_resistance ARO:3001692 OXA-229 ARO:3001692 OXA-229 is a beta-lactamase found in A. bereziniae. PMID:22508298 OXA-229 OXA-230 is a beta-lactamase found in A. bereziniae. OXA-230 antibiotic_resistance ARO:3001693 OXA-230 ARO:3001693 OXA-230 is a beta-lactamase found in A. bereziniae. PMID:22508298 OXA-230 OXA-257 is a beta-lactamase found in A. bereziniae. OXA-257 antibiotic_resistance ARO:3001694 OXA-257 ARO:3001694 OXA-257 is a beta-lactamase found in A. bereziniae. PMID:23934740 OXA-257 OXA-134 is a beta-lactamase found in A. lwoffii. OXA-134 antibiotic_resistance ARO:3001695 OXA-134 ARO:3001695 OXA-134 is a beta-lactamase found in A. lwoffii. PMID:20837764 OXA-134 The beta-lactamase name OXA-186 has been depreciated. antibiotic_resistance ARO:3001696 OXA-186 ARO:3001696 The beta-lactamase name OXA-187 has been depreciated. antibiotic_resistance ARO:3001697 OXA-187 ARO:3001697 The beta-lactamase name OXA-188 has been depreciated. antibiotic_resistance ARO:3001698 OXA-188 ARO:3001698 The beta-lactamase name OXA-189 has been depreciated. antibiotic_resistance ARO:3001699 OXA-189 ARO:3001699 The beta-lactamase name OXA-190 has been depreciated. antibiotic_resistance ARO:3001700 OXA-190 ARO:3001700 The beta-lactamase name OXA-191 has been depreciated. antibiotic_resistance ARO:3001701 OXA-191 ARO:3001701 OXA-133 is a beta-lactamase found in A. radioresistens. OXA-133 antibiotic_resistance ARO:3001702 OXA-133 ARO:3001702 OXA-133 is a beta-lactamase found in A. radioresistens. PMID:19015330 OXA-133 OXA-86 is a beta-lactamase found in Acinetobacter spp. OXA-86 antibiotic_resistance ARO:3001703 OXA-86 ARO:3001703 OXA-86 is a beta-lactamase found in Acinetobacter spp. PMID:16816400 OXA-86 OXA-87 is a beta-lactamase found in Acinetobacter spp. OXA-87 antibiotic_resistance ARO:3001704 OXA-87 ARO:3001704 OXA-87 is a beta-lactamase found in Acinetobacter spp. PMID:16816400 OXA-87 OXA-72 is a beta-lactamase found in Acinetobacter spp. OXA-72 antibiotic_resistance ARO:3001705 OXA-72 ARO:3001705 OXA-72 is a beta-lactamase found in Acinetobacter spp. PMID:17846127 OXA-72 The beta-lactamase name OXA-102 has been depreciated. antibiotic_resistance ARO:3001706 OXA-102 ARO:3001706 OXA-103 is a beta-lactamase found in Acinetobacter spp. OXA-103 antibiotic_resistance ARO:3001707 OXA-103 ARO:3001707 OXA-103 is a beta-lactamase found in Acinetobacter spp. PMID:18195058 OXA-103 OXA-105 is a beta-lactamase found in Acinetobacter spp. OXA-105 antibiotic_resistance ARO:3001708 OXA-105 ARO:3001708 OXA-105 is a beta-lactamase found in Acinetobacter spp. PMID:18195058 OXA-105 OXA-182 is a beta-lactamase found in Acinetobacter spp. OXA-182 antibiotic_resistance ARO:3001709 OXA-182 ARO:3001709 OXA-182 is a beta-lactamase found in Acinetobacter spp. PMID:20884158 OXA-182 OXA-211 is a beta-lactamase found in Acinetobacter spp. OXA-211 antibiotic_resistance ARO:3001710 OXA-211 ARO:3001710 OXA-211 is a beta-lactamase found in Acinetobacter spp. PMID:22128805 OXA-211 OXA-212 is a beta-lactamase found in Acinetobacter spp. OXA-212 antibiotic_resistance ARO:3001711 OXA-212 ARO:3001711 OXA-212 is a beta-lactamase found in Acinetobacter spp. PMID:22128805 OXA-212 OXA-213 is a beta-lactamase found in Acinetobacter spp. OXA-213 antibiotic_resistance ARO:3001712 OXA-213 ARO:3001712 OXA-213 is a beta-lactamase found in Acinetobacter spp. PMID:22128805 OXA-213 OXA-214 is a beta-lactamase found in Acinetobacter spp. OXA-214 antibiotic_resistance ARO:3001713 OXA-214 ARO:3001713 OXA-214 is a beta-lactamase found in Acinetobacter spp. PMID:22128805 OXA-214 OXA-215 is a beta-lactamase found in Acinetobacter spp. OXA-215 antibiotic_resistance ARO:3001714 OXA-215 ARO:3001714 OXA-215 is a beta-lactamase found in Acinetobacter spp. PMID:22128805 OXA-215 OXA-259 is a beta-lactamase found in Acinetobacter spp. OXA-259 antibiotic_resistance ARO:3001715 OXA-259 ARO:3001715 OXA-259 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-259 OXA-260 is a beta-lactamase found in Acinetobacter spp. OXA-260 antibiotic_resistance ARO:3001716 OXA-260 ARO:3001716 OXA-260 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-260 OXA-261 is a beta-lactamase found in Acinetobacter spp. OXA-261 antibiotic_resistance ARO:3001717 OXA-261 ARO:3001717 OXA-261 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-261 OXA-262 is a beta-lactamase found in Acinetobacter spp. OXA-262 antibiotic_resistance ARO:3001718 OXA-262 ARO:3001718 OXA-262 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-262 OXA-263 is a beta-lactamase found in Acinetobacter spp. OXA-263 antibiotic_resistance ARO:3001719 OXA-263 ARO:3001719 OXA-263 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-263 OXA-264 is a beta-lactamase found in Acinetobacter spp. OXA-264 antibiotic_resistance ARO:3001720 OXA-264 ARO:3001720 OXA-264 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-264 OXA-265 is a beta-lactamase found in Acinetobacter spp. OXA-265 antibiotic_resistance ARO:3001721 OXA-265 ARO:3001721 OXA-265 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-265 OXA-266 is a beta-lactamase found in Acinetobacter spp. OXA-266 antibiotic_resistance ARO:3001722 OXA-266 ARO:3001722 OXA-266 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-266 OXA-267 is a beta-lactamase found in Acinetobacter spp. OXA-267 antibiotic_resistance ARO:3001723 OXA-267 ARO:3001723 OXA-267 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-267 OXA-268 is a beta-lactamase found in Acinetobacter spp. OXA-268 antibiotic_resistance ARO:3001724 OXA-268 ARO:3001724 OXA-268 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-268 OXA-269 is a beta-lactamase found in Acinetobacter spp. OXA-269 antibiotic_resistance ARO:3001725 OXA-269 ARO:3001725 OXA-269 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-269 OXA-270 is a beta-lactamase found in Acinetobacter spp. OXA-270 antibiotic_resistance ARO:3001726 OXA-270 ARO:3001726 OXA-270 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-270 OXA-271 is a beta-lactamase found in Acinetobacter spp. OXA-271 antibiotic_resistance ARO:3001727 OXA-271 ARO:3001727 OXA-271 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-271 OXA-272 is a beta-lactamase found in Acinetobacter spp. OXA-272 antibiotic_resistance ARO:3001728 OXA-272 ARO:3001728 OXA-272 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-272 OXA-273 is a beta-lactamase found in Acinetobacter spp. OXA-273 antibiotic_resistance ARO:3001729 OXA-273 ARO:3001729 OXA-273 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-273 OXA-274 is a beta-lactamase found in Acinetobacter spp. OXA-274 antibiotic_resistance ARO:3001730 OXA-274 ARO:3001730 OXA-274 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 PMID:30247543 OXA-274 OXA-275 is a beta-lactamase found in Acinetobacter spp. OXA-275 antibiotic_resistance ARO:3001731 OXA-275 ARO:3001731 OXA-275 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-275 OXA-276 is a beta-lactamase found in Acinetobacter spp. OXA-276 antibiotic_resistance ARO:3001732 OXA-276 ARO:3001732 OXA-276 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-276 OXA-277 is a beta-lactamase found in Acinetobacter spp. OXA-277 antibiotic_resistance ARO:3001733 OXA-277 ARO:3001733 OXA-277 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-277 OXA-279 is a beta-lactamase found in Acinetobacter spp. OXA-279 antibiotic_resistance ARO:3001734 OXA-279 ARO:3001734 OXA-279 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-279 OXA-280 is a beta-lactamase found in Acinetobacter spp. OXA-280 antibiotic_resistance ARO:3001735 OXA-280 ARO:3001735 OXA-280 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-280 OXA-281 is a beta-lactamase found in Acinetobacter spp. OXA-281 antibiotic_resistance ARO:3001736 OXA-281 ARO:3001736 OXA-281 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-281 OXA-282 is a beta-lactamase found in Acinetobacter spp. OXA-282 antibiotic_resistance ARO:3001737 OXA-282 ARO:3001737 OXA-282 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-282 OXA-283 is a beta-lactamase found in Acinetobacter spp. OXA-283 antibiotic_resistance ARO:3001738 OXA-283 ARO:3001738 OXA-283 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-283 OXA-284 is a beta-lactamase found in Acinetobacter spp. OXA-284 antibiotic_resistance ARO:3001739 OXA-284 ARO:3001739 OXA-284 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-284 OXA-285 is a beta-lactamase found in Acinetobacter spp. OXA-285 antibiotic_resistance ARO:3001740 OXA-285 ARO:3001740 OXA-285 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-285 OXA-286 is a beta-lactamase found in Acinetobacter spp. OXA-286 antibiotic_resistance ARO:3001741 OXA-286 ARO:3001741 OXA-286 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 PMID:30247543 OXA-286 OXA-287 is a beta-lactamase found in Acinetobacter spp. OXA-287 antibiotic_resistance ARO:3001742 OXA-287 ARO:3001742 OXA-287 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-287 OXA-288 is a beta-lactamase found in Acinetobacter spp. OXA-288 antibiotic_resistance ARO:3001743 OXA-288 ARO:3001743 OXA-288 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-288 OXA-289 is a beta-lactamase found in Acinetobacter spp. OXA-289 antibiotic_resistance ARO:3001744 OXA-289 ARO:3001744 OXA-289 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-289 OXA-290 is a beta-lactamase found in Acinetobacter spp. OXA-290 antibiotic_resistance ARO:3001745 OXA-290 ARO:3001745 OXA-290 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-290 OXA-291 is a beta-lactamase found in Acinetobacter spp. OXA-291 antibiotic_resistance ARO:3001746 OXA-291 ARO:3001746 OXA-291 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-291 OXA-292 is a beta-lactamase found in Acinetobacter spp. OXA-292 antibiotic_resistance ARO:3001747 OXA-292 ARO:3001747 OXA-292 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-292 OXA-293 is a beta-lactamase found in Acinetobacter spp. OXA-293 antibiotic_resistance ARO:3001748 OXA-293 ARO:3001748 OXA-293 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-293 OXA-294 is a beta-lactamase found in Acinetobacter spp. OXA-294 antibiotic_resistance ARO:3001749 OXA-294 ARO:3001749 OXA-294 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-294 OXA-295 is a beta-lactamase found in Acinetobacter spp. OXA-295 antibiotic_resistance ARO:3001750 OXA-295 ARO:3001750 OXA-295 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-295 OXA-296 is a beta-lactamase found in Acinetobacter spp. OXA-296 antibiotic_resistance ARO:3001751 OXA-296 ARO:3001751 OXA-296 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 PMID:30247543 OXA-296 OXA-297 is a beta-lactamase found in Acinetobacter spp. OXA-297 antibiotic_resistance ARO:3001752 OXA-297 ARO:3001752 OXA-297 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-297 OXA-298 is a beta-lactamase found in Acinetobacter spp. OXA-298 antibiotic_resistance ARO:3001753 OXA-298 ARO:3001753 OXA-298 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-298 OXA-299 is a beta-lactamase found in Acinetobacter spp. OXA-299 antibiotic_resistance ARO:3001754 OXA-299 ARO:3001754 OXA-299 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-299 OXA-300 is a beta-lactamase found in Acinetobacter spp. OXA-300 antibiotic_resistance ARO:3001755 OXA-300 ARO:3001755 OXA-300 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-300 OXA-301 is a beta-lactamase found in Acinetobacter spp. OXA-301 antibiotic_resistance ARO:3001756 OXA-301 ARO:3001756 OXA-301 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-301 OXA-302 is a beta-lactamase found in Acinetobacter spp. OXA-302 antibiotic_resistance ARO:3001757 OXA-302 ARO:3001757 OXA-302 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-302 OXA-303 is a beta-lactamase found in Acinetobacter spp. OXA-303 antibiotic_resistance ARO:3001758 OXA-303 ARO:3001758 OXA-303 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-303 OXA-304 is a beta-lactamase found in Acinetobacter spp. OXA-304 antibiotic_resistance ARO:3001759 OXA-304 ARO:3001759 OXA-304 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-304 OXA-305 is a beta-lactamase found in Acinetobacter spp. OXA-305 antibiotic_resistance ARO:3001760 OXA-305 ARO:3001760 OXA-305 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-305 OXA-306 is a beta-lactamase found in Acinetobacter spp. OXA-306 antibiotic_resistance ARO:3001761 OXA-306 ARO:3001761 OXA-306 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-306 OXA-307 is a beta-lactamase found in Acinetobacter spp. OXA-307 antibiotic_resistance ARO:3001762 OXA-307 ARO:3001762 OXA-307 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-307 OXA-308 is a beta-lactamase found in Acinetobacter spp. OXA-308 antibiotic_resistance ARO:3001763 OXA-308 ARO:3001763 OXA-308 is a beta-lactamase found in Acinetobacter spp. PMID:24277043 OXA-308 OXA-63 is a beta-lactamase found in Brachyspira spp. OXA-63 antibiotic_resistance ARO:3001764 OXA-63 ARO:3001764 OXA-63 is a beta-lactamase found in Brachyspira spp. PMID:18212108 OXA-63 OXA-136 is a beta-lactamase found in Brachyspira spp. OXA-136 antibiotic_resistance ARO:3001765 OXA-136 ARO:3001765 OXA-136 is a beta-lactamase found in Brachyspira spp. PMID:18719182 OXA-136 OXA-192 is a beta-lactamase found in Brachyspira spp. OXA-192 antibiotic_resistance ARO:3001766 OXA-192 ARO:3001766 OXA-192 is a beta-lactamase found in Brachyspira spp. PMID:21812718 OXA-192 OXA-137 is a beta-lactamase found in Brachyspira spp. OXA-137 antibiotic_resistance ARO:3001767 OXA-137 ARO:3001767 OXA-137 is a beta-lactamase found in Brachyspira spp. PMID:18719182 OXA-137 OXA-118 is a beta-lactamase found in Burkholderia cepacia. OXA-118 antibiotic_resistance ARO:3001768 OXA-118 ARO:3001768 OXA-118 is a beta-lactamase found in Burkholderia cepacia. PMID:11972706 OXA-118 OXA-42 is a beta-lactamase found in Burkholderia pseudomallei. OXA-42 antibiotic_resistance ARO:3001769 OXA-42 ARO:3001769 OXA-42 is a beta-lactamase found in Burkholderia pseudomallei. PMID:12356787 OXA-42 OXA-43 is a beta-lactamase found in Burkholderia pseudomallei. OXA-43 antibiotic_resistance ARO:3001770 OXA-43 ARO:3001770 OXA-43 is a beta-lactamase found in Burkholderia pseudomallei. PMID:12356787 OXA-43 OXA-57 is a beta-lactamase found in Burkholderia pseudomallei. OXA-57 antibiotic_resistance ARO:3001771 OXA-57 ARO:3001771 OXA-57 is a beta-lactamase found in Burkholderia pseudomallei. PMID:15793160 OXA-57 OXA-59 is a beta-lactamase found in Burkholderia pseudomallei. OXA-59 antibiotic_resistance ARO:3001772 OXA-59 ARO:3001772 OXA-59 is a beta-lactamase found in Burkholderia pseudomallei. PMID:15793160 OXA-59 OXA-61 is a beta-lactamase found in Campylobacter jejuni. OXA-61 antibiotic_resistance ARO:3001773 OXA-61 ARO:3001773 OXA-61 is a beta-lactamase found in Campylobacter jejuni. PMID:15917560 OXA-61 OXA-370 is a beta-lactamase found in Enterobacter hormaechei. OXA-370 antibiotic_resistance ARO:3001774 OXA-370 ARO:3001774 OXA-370 OXA-119 is a beta-lactamase found in Enterobacteriaceae. OXA-119 antibiotic_resistance ARO:3001775 OXA-119 ARO:3001775 OXA-119 is a beta-lactamase found in Enterobacteriaceae. PMID:19719593 OXA-119 OXA-162 is a beta-lactamase found in Enterobacteriaceae. OXA-162 antibiotic_resistance ARO:3001776 OXA-162 ARO:3001776 OXA-162 is a beta-lactamase found in Enterobacteriaceae. PMID:22290940 OXA-162 OXA-347 is a beta-lactamase found in Enterobacteriaceae. OXA-347 antibiotic_resistance ARO:3001777 OXA-347 ARO:3001777 OXA-347 is a beta-lactamase found in Enterobacteriaceae. PMID:22845886 OXA-347 OXA-232 is a beta-lactamase found in Enterobacteriaceae. OXA-232 antibiotic_resistance ARO:3001778 OXA-232 ARO:3001778 OXA-232 is a beta-lactamase found in Enterobacteriaceae. PMID:23305656 OXA-232 OXA-146 is a beta-lactamase found in Enterobacteriaceae. OXA-146 antibiotic_resistance ARO:3001779 OXA-146 ARO:3001779 OXA-146 is a beta-lactamase found in Enterobacteriaceae. PMID:23877677 OXA-146 OXA-85 is a beta-lactamase found in Fusobacterium nucleatum. OXA-85 antibiotic_resistance ARO:3001780 OXA-85 ARO:3001780 OXA-85 is a beta-lactamase found in Fusobacterium nucleatum. PMID:16870757 OXA-85 OXA-47 is a beta-lactamase found in Klebsiella pneumoniae. OXA-47 antibiotic_resistance ARO:3001781 OXA-47 ARO:3001781 OXA-47 is a beta-lactamase found in Klebsiella pneumoniae. PMID:14693513 OXA-47 OXA-48 is a beta-lactamase found in Klebsiella pneumoniae. OXA-48 antibiotic_resistance ARO:3001782 OXA-48 ARO:3001782 OXA-48 is a beta-lactamase found in Klebsiella pneumoniae. PMID:14693513 OXA-48 OXA-163 is a beta-lactamase found in Klebsiella pneumoniae. OXA-163 antibiotic_resistance ARO:3001783 OXA-163 ARO:3001783 OXA-163 is a beta-lactamase found in Klebsiella pneumoniae. PMID:21422200 OXA-163 OXA-181 is a beta-lactamase found in Klebsiella pneumoniae. OXA-181 antibiotic_resistance ARO:3001784 OXA-181 ARO:3001784 OXA-181 is a beta-lactamase found in Klebsiella pneumoniae. PMID:21768505 OXA-181 OXA-73 is a beta-lactamase found in Klebsiella pneumonia. OXA-73 antibiotic_resistance ARO:3001785 OXA-73 ARO:3001785 OXA-73 is a beta-lactamase found in Klebsiella pneumonia. PMID:22842601 OXA-73 OXA-244 is a beta-lactamase found in Klebsiella pneumoniae. OXA-244 antibiotic_resistance ARO:3001786 OXA-244 ARO:3001786 OXA-244 is a beta-lactamase found in Klebsiella pneumoniae. PMID:23034714 OXA-244 OXA-245 is a beta-lactamase found in Klebsiella pneumoniae. OXA-245 antibiotic_resistance ARO:3001787 OXA-245 ARO:3001787 OXA-245 is a beta-lactamase found in Klebsiella pneumoniae. PMID:23034714 OXA-245 OXA-204 is a beta-lactamase found in Klebsiella pneumoniae. OXA-204 antibiotic_resistance ARO:3001788 OXA-204 ARO:3001788 OXA-204 is a beta-lactamase found in Klebsiella pneumoniae. PMID:23114766 OXA-204 OXA-247 is a beta-lactamase found in Klebsiella pneumoniae. OXA-247 antibiotic_resistance ARO:3001791 OXA-247 ARO:3001791 OXA-247 is a beta-lactamase found in Klebsiella pneumoniae. PMID:23402333 OXA-247 OXA-62 is a beta-lactamase found in Pandoraea pnomenusa. OXA-62 antibiotic_resistance ARO:3001792 OXA-62 ARO:3001792 OXA-62 is a beta-lactamase found in Pandoraea pnomenusa. PMID:16569848 OXA-62 OXA-320 is a beta-lactamase found in Proteus mirabilis. OXA-320 antibiotic_resistance ARO:3001793 OXA-320 ARO:3001793 OXA-320 is a beta-lactamase found in Proteus mirabilis. PMID:24027220 OXA-320 OXA-45 is a beta-lactamase found in Pseudomonas aeruginosa. OXA-45 antibiotic_resistance ARO:3001794 OXA-45 ARO:3001794 OXA-45 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:12936985 OXA-45 OXA-56 is a beta-lactamase found in Pseudomonas aeruginosa. OXA-56 antibiotic_resistance ARO:3001795 OXA-56 ARO:3001795 OXA-56 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:15047554 OXA-56 OXA-50 is a beta-lactamase found in Pseudomonas aeruginosa. It confers decreased susceptibility to ampicillin and ticarcillin and, interestingly, to moxalactam and meropenem in P. aeruginosa but not in E. coli. Also confers resistance to piperacillin-tazobactam and cephalotin. OXA-50 antibiotic_resistance ARO:3001796 OXA-50 ARO:3001796 OXA-50 is a beta-lactamase found in Pseudomonas aeruginosa. It confers decreased susceptibility to ampicillin and ticarcillin and, interestingly, to moxalactam and meropenem in P. aeruginosa but not in E. coli. Also confers resistance to piperacillin-tazobactam and cephalotin. PMID:15155197 OXA-50 OXA-46 is a beta-lactamase found in Pseudomonas aeruginosa. OXA-46 OXA-81 antibiotic_resistance ARO:3001797 OXA-46 ARO:3001797 OXA-46 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:15855521 OXA-46 OXA-74 is a beta-lactamase found in Pseudomonas aeruginosa. OXA-74 antibiotic_resistance ARO:3001798 OXA-74 ARO:3001798 OXA-74 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:17634312 OXA-74 OXA-161 is a beta-lactamase found in Pseudomonas aeruginosa. OXA-161 antibiotic_resistance ARO:3001799 OXA-161 ARO:3001799 OXA-161 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:19770278 OXA-161 OXA-226 is a beta-lactamase found in Pseudomonas aeruginosa. OXA-226 antibiotic_resistance ARO:3001800 OXA-226 ARO:3001800 OXA-226 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:19933793 OXA-226 OXA-147 is a beta-lactamase found in Pseudomonas aeruginosa. OXA-147 antibiotic_resistance ARO:3001801 OXA-147 ARO:3001801 OXA-147 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:20008045 OXA-147 OXA-141 is a beta-lactamase found in Pseudomonas aeruginosa. OXA-141 antibiotic_resistance ARO:3001802 OXA-141 ARO:3001802 OXA-141 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:20482453 OXA-141 OXA-142 is a beta-lactamase found in Pseudomonas aeruginosa. OXA-142 antibiotic_resistance ARO:3001803 OXA-142 ARO:3001803 OXA-142 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:20482453 OXA-142 OXA-145 is a beta-lactamase found in Pseudomonas aeruginosa. OXA-145 antibiotic_resistance ARO:3001804 OXA-145 ARO:3001804 OXA-145 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:21665906 OXA-145 OXA-198 is a beta-lactamase found in Pseudomonas aeruginosa. OXA-198 antibiotic_resistance ARO:3001805 OXA-198 ARO:3001805 OXA-198 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:21788473 OXA-198 OXA-224 is a beta-lactamase found in Pseudomonas aeruginosa. OXA-224 antibiotic_resistance ARO:3001806 OXA-224 ARO:3001806 OXA-224 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:22290962 OXA-224 OXA-246 is a beta-lactamase found in Pseudomonas aeruginosa. OXA-246 antibiotic_resistance ARO:3001807 OXA-246 ARO:3001807 OXA-246 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:24398232 OXA-246 OXA-60 is a beta-lactamase found in Ralstonia pickettii. OXA-60 antibiotic_resistance ARO:3001808 OXA-60 ARO:3001808 OXA-60 is a beta-lactamase found in Ralstonia pickettii. PMID:15504844 OXA-60 OXA-209 is a beta-lactamase found in Riemerella anatipestifer. OXA-209 antibiotic_resistance ARO:3001809 OXA-209 ARO:3001809 OXA-209 is a beta-lactamase found in Riemerella anatipestifer. PMID:21820820 OXA-209 OXA-53 is a beta-lactamase found in Salmonella enterica. OXA-53 antibiotic_resistance ARO:3001810 OXA-53 ARO:3001810 OXA-53 is a beta-lactamase found in Salmonella enterica. PMID:15231768 OXA-53 OXA-129 is a beta-lactamase found in Salmonella enterica. OXA-129 antibiotic_resistance ARO:3001811 OXA-129 ARO:3001811 OXA-129 is a beta-lactamase found in Salmonella enterica. PMID:18571903 OXA-129 OXA-54 is a beta-lactamase found in Shewanella spp. OXA-54 antibiotic_resistance ARO:3001812 OXA-54 ARO:3001812 OXA-54 is a beta-lactamase found in Shewanella spp. PMID:14693565 OXA-54 OXA-55 is a beta-lactamase found in Shewanella spp. OXA-55 antibiotic_resistance ARO:3001813 OXA-55 ARO:3001813 OXA-55 is a beta-lactamase found in Shewanella spp. PMID:15105119 OXA-55 OXA-199 is a beta-lactamase found in Shewanella spp. OXA-199 antibiotic_resistance ARO:3001814 OXA-199 ARO:3001814 OXA-199 is a beta-lactamase found in Shewanella spp. PMID:23110226 OXA-199 ACC-1 is a beta-lactamase found in Klebsiella pneumoniae. ACC-1 antibiotic_resistance ARO:3001815 ACC-1 ARO:3001815 ACC-1 is a beta-lactamase found in Klebsiella pneumoniae. PMID:10428914 ACC-1 ACC-2 is a beta-lactamase found in Hafnia alvei. ACC-2 antibiotic_resistance ARO:3001816 ACC-2 ARO:3001816 ACC-2 is a beta-lactamase found in Hafnia alvei. PMID:10817695 ACC-2 ACC-3 is a beta-lactamase found in Hafnia alvei. ACC-3 antibiotic_resistance ARO:3001817 ACC-3 ARO:3001817 ACC-3 is a beta-lactamase found in Hafnia alvei. PMID:10817695 ACC-3 ACC-4 is a beta-lactamase found in Escherichia coli. ACC-4 antibiotic_resistance ARO:3001818 ACC-4 ARO:3001818 ACC-4 is a beta-lactamase found in Escherichia coli. PMID:17664321 ACC-4 ACC-5 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. ACC-5 antibiotic_resistance ARO:3001819 ACC-5 ARO:3001819 ACC-5 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. PMID:24267783 ACC-5 ACT-1 is a beta-lactamase found in Klebsiella pneumoniae. ACT-1 antibiotic_resistance ARO:3001821 ACT-1 ARO:3001821 ACT-1 is a beta-lactamase found in Klebsiella pneumoniae. PMID:9055993 ACT-1 ACT-2 is a beta-lactamase found in Klebsiella pneumoniae. ACT-2 antibiotic_resistance ARO:3001822 ACT-2 ARO:3001822 ACT-2 is a beta-lactamase found in Klebsiella pneumoniae. PMID:23093031 ACT-2 ACT-3 is a beta-lactamase found in Klebsiella pneumoniae. ACT-3 antibiotic_resistance ARO:3001823 ACT-3 ARO:3001823 ACT-3 is a beta-lactamase found in Klebsiella pneumoniae. PMID:18789849 ACT-3 ACT-5 is a beta-lactamase found in Escherichia coli. ACT-5 antibiotic_resistance ARO:3001824 ACT-5 ARO:3001824 ACT-5 is a beta-lactamase found in Escherichia coli. PMID:23643553 ACT-5 ACT-6 is a beta-lactamase found in Klebsiella pneumoniae. ACT-6 antibiotic_resistance ARO:3001825 ACT-6 ARO:3001825 ACT-6 is a beta-lactamase found in Klebsiella pneumoniae. PMID:21304534 ACT-6 ACT-9 is a beta-lactamase found in Pantoea agglomerans. This sequence and nomenclature has been superseded by ACT-143. ACT-9 antibiotic_resistance ARO:3001826 ACT-9 ARO:3001826 ACT-9 is a beta-lactamase found in Pantoea agglomerans. This sequence and nomenclature has been superseded by ACT-143. PMID:21690276 ACT-9 ACT-16 is a beta-lactamase found in Enterobacteriaceae. ACT-16 antibiotic_resistance ARO:3001827 ACT-16 ARO:3001827 ACT-16 is a beta-lactamase found in Enterobacteriaceae. PMID:24336426 ACT-16 ACT-23 is a beta-lactamase found in Escherichia coli. ACT-23 antibiotic_resistance ARO:3001828 ACT-23 ARO:3001828 ACT-23 is a beta-lactamase found in Escherichia coli. PMID:24629772 ACT-23 ACT-4 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. ACT-4 antibiotic_resistance ARO:3001829 ACT-4 ARO:3001829 ACT-4 ACT-7 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. ACT-7 antibiotic_resistance ARO:3001830 ACT-7 ARO:3001830 ACT-7 ACT-8 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. ACT-8 antibiotic_resistance ARO:3001831 ACT-8 ARO:3001831 ACT-8 ACT-10 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. ACT-10 antibiotic_resistance ARO:3001832 ACT-10 ARO:3001832 ACT-10 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. PMID:25312010 ACT-10 ACT-11 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001833 ACT-11 ARO:3001833 ACT-12 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. ACT-12 antibiotic_resistance ARO:3001834 ACT-12 ARO:3001834 ACT-12 ACT-13 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. ACT-13 antibiotic_resistance ARO:3001835 ACT-13 ARO:3001835 ACT-13 ACT-14 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. ACT-14 antibiotic_resistance ARO:3001836 ACT-14 ARO:3001836 ACT-14 ACT-15 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. ACT-15 antibiotic_resistance ARO:3001837 ACT-15 ARO:3001837 ACT-15 ACT-17 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. ACT-17 antibiotic_resistance ARO:3001838 ACT-17 ARO:3001838 ACT-17 ACT-18 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. ACT-18 antibiotic_resistance ARO:3001839 ACT-18 ARO:3001839 ACT-18 ACT-19 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. ACT-19 antibiotic_resistance ARO:3001840 ACT-19 ARO:3001840 ACT-19 ACT-20 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. ACT-20 antibiotic_resistance ARO:3001841 ACT-20 ARO:3001841 ACT-20 ACT-21 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. ACT-21 antibiotic_resistance ARO:3001842 ACT-21 ARO:3001842 ACT-21 ACT-22 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. ACT-22 antibiotic_resistance ARO:3001843 ACT-22 ARO:3001843 ACT-22 ACT-24 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. ACT-24 antibiotic_resistance ARO:3001844 ACT-24 ARO:3001844 ACT-24 ACT-25 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. ACT-25 antibiotic_resistance ARO:3001845 ACT-25 ARO:3001845 ACT-25 ACT-27 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. ACT-27 antibiotic_resistance ARO:3001847 ACT-27 ARO:3001847 ACT-27 ACT-28 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. ACT-28 antibiotic_resistance ARO:3001848 ACT-28 ARO:3001848 ACT-28 ACT-29 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. ACT-29 antibiotic_resistance ARO:3001849 ACT-29 ARO:3001849 ACT-29 ACT-30 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. ACT-30 antibiotic_resistance ARO:3001850 ACT-30 ARO:3001850 ACT-30 ACT-31 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. ACT-31 antibiotic_resistance ARO:3001851 ACT-31 ARO:3001851 ACT-31 ACT-32 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. ACT-32 antibiotic_resistance ARO:3001852 ACT-32 ARO:3001852 ACT-32 ACT-33 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. ACT-33 antibiotic_resistance ARO:3001853 ACT-33 ARO:3001853 ACT-33 ACT-34 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. ACT-34 antibiotic_resistance ARO:3001854 ACT-34 ARO:3001854 ACT-34 ACT-35 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. ACT-35 antibiotic_resistance ARO:3001855 ACT-35 ARO:3001855 ACT-35 CFE-1 is a beta-lactamase found in Escherichia coli. CFE-1 antibiotic_resistance ARO:3001856 CFE-1 ARO:3001856 CFE-1 is a beta-lactamase found in Escherichia coli. PMID:15047515 CFE-1 LAT-1 is a beta-lactamase found in Klebsiella pneumoniae. LAT-1 LAT-4 antibiotic_resistance ARO:3001857 LAT-1 ARO:3001857 LAT-1 is a beta-lactamase found in Klebsiella pneumoniae. PMID:7811049 LAT-1 IMI-1 is a beta-lactamase found in Enterobacter cloacae. IMI-1 antibiotic_resistance ARO:3001858 IMI-1 ARO:3001858 IMI-1 is a beta-lactamase found in Enterobacter cloacae. PMID:8878585 IMI-1 IMI-2 is a beta-lactamase found in Enterobacteriaceae. IMI-2 antibiotic_resistance ARO:3001859 IMI-2 ARO:3001859 IMI-2 is a beta-lactamase found in Enterobacteriaceae. PMID:15752444 PMID:21192875 IMI-2 IMI-3 is a beta-lactamase found in Enterobacteriaceae. IMI-3 antibiotic_resistance ARO:3001860 IMI-3 ARO:3001860 IMI-3 is a beta-lactamase found in Enterobacteriaceae. PMID:21192875 IMI-3 IMI-4 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. IMI-4 antibiotic_resistance ARO:3001861 IMI-4 ARO:3001861 IMI-4 IMI-5 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. IMI-5 antibiotic_resistance ARO:3001862 IMI-5 ARO:3001862 IMI-5 IMI-6 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. IMI-6 antibiotic_resistance ARO:3001863 IMI-6 ARO:3001863 IMI-6 CTX-M-1 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-1 MEN-1 antibiotic_resistance ARO:3001864 CTX-M-1 ARO:3001864 CTX-M-1 is a beta-lactamase found in the Enterobacteriaceae family. PMID:8834913 CTX-M-1 CTX-M-2 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-2 antibiotic_resistance ARO:3001865 CTX-M-2 ARO:3001865 CTX-M-2 is a beta-lactamase found in the Enterobacteriaceae family. PMID:8834913 CTX-M-2 CTX-M-3 is a beta-lactamase found in Citrobacter freundii. CTX-M-133 CTX-M-3 antibiotic_resistance ARO:3001866 CTX-M-3 ARO:3001866 CTX-M-3 is a beta-lactamase found in Citrobacter freundii. PMID:33416461 PMID:9559791 CTX-M-3 CTX-M-4 is a beta-lactamase found in Salmonella typhimurium. CTX-M-4 antibiotic_resistance ARO:3001867 CTX-M-4 ARO:3001867 CTX-M-4 is a beta-lactamase found in Salmonella typhimurium. PMID:9593162 CTX-M-4 CTX-M-5 is a beta-lactamase found in Salmonella typhimurium. CTX-M-5 antibiotic_resistance ARO:3001868 CTX-M-5 ARO:3001868 CTX-M-5 is a beta-lactamase found in Salmonella typhimurium. PMID:9687393 CTX-M-5 CTX-M-6 is a beta-lactamase found in Salmonella typhimurium. CTX-M-6 antibiotic_resistance ARO:3001869 CTX-M-6 ARO:3001869 CTX-M-6 is a beta-lactamase found in Salmonella typhimurium. PMID:9742701 CTX-M-6 CTX-M-7 is a beta-lactamase found in Salmonella typhimurium. CTX-M-7 antibiotic_resistance ARO:3001870 CTX-M-7 ARO:3001870 CTX-M-7 is a beta-lactamase found in Salmonella typhimurium. PMID:9742701 CTX-M-7 CTX-M-8 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-8 antibiotic_resistance ARO:3001871 CTX-M-8 ARO:3001871 CTX-M-8 is a beta-lactamase found in the Enterobacteriaceae family. PMID:10858358 CTX-M-8 CTX-M-9 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-9 antibiotic_resistance ARO:3001872 CTX-M-9 ARO:3001872 CTX-M-9 is a beta-lactamase found in the Enterobacteriaceae family. PMID:11850241 CTX-M-9 CTX-M-10 is a beta-lactamase found in Escherichia coli. CTX-M-10 antibiotic_resistance ARO:3001873 CTX-M-10 ARO:3001873 CTX-M-10 is a beta-lactamase found in Escherichia coli. PMID:11158766 CTX-M-10 CTX-M-11 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-11 antibiotic_resistance ARO:3001874 CTX-M-11 ARO:3001874 CTX-M-11 CTX-M-12 is a beta-lactamase found in Klebsiella pneumoniae. CTX-M-12 antibiotic_resistance ARO:3001875 CTX-M-12 ARO:3001875 CTX-M-12 is a beta-lactamase found in Klebsiella pneumoniae. PMID:11408239 CTX-M-12 CTX-M-13 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-13 antibiotic_resistance ARO:3001876 CTX-M-13 ARO:3001876 CTX-M-13 is a beta-lactamase found in the Enterobacteriaceae family. PMID:11850241 CTX-M-13 CTX-M-14 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-14 CTX-M-18 antibiotic_resistance ARO:3001877 CTX-M-14 ARO:3001877 CTX-M-14 is a beta-lactamase found in the Enterobacteriaceae family. PMID:11850241 CTX-M-14 CTX-M-15 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-15 UOE-1 antibiotic_resistance ARO:3001878 CTX-M-15 ARO:3001878 CTX-M-15 is a beta-lactamase found in the Enterobacteriaceae family. PMID:11470367 PMID:12461028 PMID:33416461 CTX-M-15 CTX-M-16 is a beta-lactamase found in Escherichia coli. CTX-M-16 antibiotic_resistance ARO:3001879 CTX-M-16 ARO:3001879 CTX-M-16 is a beta-lactamase found in Escherichia coli. PMID:11451684 CTX-M-16 CTX-M-17 is a beta-lactamase found in Klebsiella pneumoniae. CTX-M-17 antibiotic_resistance ARO:3001880 CTX-M-17 ARO:3001880 CTX-M-17 is a beta-lactamase found in Klebsiella pneumoniae. PMID:11959547 CTX-M-17 CTX-M-19 is a beta-lactamase found in Klebsiella pneumoniae. CTX-M-19 antibiotic_resistance ARO:3001881 CTX-M-19 ARO:3001881 CTX-M-19 is a beta-lactamase found in Klebsiella pneumoniae. PMID:11709308 CTX-M-19 CTX-M-20 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-20 antibiotic_resistance ARO:3001882 CTX-M-20 ARO:3001882 CTX-M-20 is a beta-lactamase found in the Enterobacteriaceae family. PMID:12007800 CTX-M-20 CTX-M-21 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-21 antibiotic_resistance ARO:3001883 CTX-M-21 ARO:3001883 CTX-M-21 is a beta-lactamase found in the Enterobacteriaceae family. PMID:12007800 CTX-M-21 CTX-M-22 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-22 antibiotic_resistance ARO:3001884 CTX-M-22 ARO:3001884 CTX-M-22 is a beta-lactamase found in the Enterobacteriaceae family. PMID:16533535 CTX-M-22 CTX-M-23 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-23 antibiotic_resistance ARO:3001885 CTX-M-23 ARO:3001885 CTX-M-23 is a beta-lactamase found in the Enterobacteriaceae family. PMID:15201232 CTX-M-23 CTX-M-24 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-24 antibiotic_resistance ARO:3001886 CTX-M-24 ARO:3001886 CTX-M-24 is a beta-lactamase found in the Enterobacteriaceae family. PMID:16291869 CTX-M-24 CTX-M-25 is a beta-lactamase found in Escherichia coli. CTX-M-25 antibiotic_resistance ARO:3001887 CTX-M-25 ARO:3001887 CTX-M-25 is a beta-lactamase found in Escherichia coli. PMID:15561863 CTX-M-25 CTX-M-26 is a beta-lactamase found in Klebsiella pneumoniae. CTX-M-26 antibiotic_resistance ARO:3001888 CTX-M-26 ARO:3001888 CTX-M-26 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15561863 CTX-M-26 CTX-M-27 is a beta-lactamase found in Escherichia coli. CTX-M-27 antibiotic_resistance ARO:3001889 CTX-M-27 ARO:3001889 CTX-M-27 is a beta-lactamase found in Escherichia coli. PMID:12775683 PMID:33416461 CTX-M-27 CTX-M-28 is a beta-lactamase found in Salmonella enterica. CTX-M-28 antibiotic_resistance ARO:3001890 CTX-M-28 ARO:3001890 CTX-M-28 is a beta-lactamase found in Salmonella enterica. PMID:15941775 CTX-M-28 CTX-M-29 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-29 antibiotic_resistance ARO:3001891 CTX-M-29 ARO:3001891 CTX-M-29 is a beta-lactamase found in the Enterobacteriaceae family. PMID:16533535 CTX-M-29 CTX-M-30 is a beta-lactamase found in Citrobacter freundii. CTX-M-30 antibiotic_resistance ARO:3001892 CTX-M-30 ARO:3001892 CTX-M-30 is a beta-lactamase found in Citrobacter freundii. PMID:15504875 CTX-M-30 CTX-M-31 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-31 antibiotic_resistance ARO:3001893 CTX-M-31 ARO:3001893 CTX-M-31 is a beta-lactamase found in the Enterobacteriaceae family. PMID:12936986 CTX-M-31 CTX-M-32 is a beta-lactamase found in Escherichia coli. CTX-M-32 antibiotic_resistance ARO:3001894 CTX-M-32 ARO:3001894 CTX-M-32 is a beta-lactamase found in Escherichia coli. PMID:15155242 CTX-M-32 CTX-M-33 is a beta-lactamase found in Salmonella enterica. CTX-M-33 antibiotic_resistance ARO:3001895 CTX-M-33 ARO:3001895 CTX-M-33 is a beta-lactamase found in Salmonella enterica. PMID:17234386 CTX-M-33 CTX-M-34 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-34 antibiotic_resistance ARO:3001896 CTX-M-34 ARO:3001896 CTX-M-34 is a beta-lactamase found in the Enterobacteriaceae family. PMID:16244084 CTX-M-34 CTX-M-35 is a beta-lactamase found in Citrobacter koseri. CTX-M-35 antibiotic_resistance ARO:3001897 CTX-M-35 ARO:3001897 CTX-M-35 is a beta-lactamase found in Citrobacter koseri. PMID:20138478 CTX-M-35 CTX-M-36 is a beta-lactamase found in Escherichia coli. CTX-M-36 antibiotic_resistance ARO:3001898 CTX-M-36 ARO:3001898 CTX-M-36 is a beta-lactamase found in Escherichia coli. PMID:21940649 CTX-M-36 CTX-M-37 is a beta-lactamase found in Salmonella enterica. CTX-M-37 antibiotic_resistance ARO:3001899 CTX-M-37 ARO:3001899 CTX-M-37 is a beta-lactamase found in Salmonella enterica. PMID:16949257 CTX-M-37 CTX-M-38 is a beta-lactamase found in Escherichia coli. CTX-M-38 antibiotic_resistance ARO:3001900 CTX-M-38 ARO:3001900 CTX-M-38 is a beta-lactamase found in Escherichia coli. PMID:19927355 CTX-M-38 CTX-M-39 is a beta-lactamase found in Escherichia coli. CTX-M-39 antibiotic_resistance ARO:3001901 CTX-M-39 ARO:3001901 CTX-M-39 is a beta-lactamase found in Escherichia coli. PMID:16251320 CTX-M-39 CTX-M-40 is a beta-lactamase found in Escherichia coli. CTX-M-40 antibiotic_resistance ARO:3001902 CTX-M-40 ARO:3001902 CTX-M-40 is a beta-lactamase found in Escherichia coli. PMID:16697557 CTX-M-40 CTX-M-41 is a beta-lactamase found in Proteus mirabilis. CTX-M-41 antibiotic_resistance ARO:3001903 CTX-M-41 ARO:3001903 CTX-M-41 is a beta-lactamase found in Proteus mirabilis. PMID:18487232 CTX-M-41 CTX-M-42 is a beta-lactamase found in Escherichia coli. CTX-M-42 antibiotic_resistance ARO:3001904 CTX-M-42 ARO:3001904 CTX-M-42 is a beta-lactamase found in Escherichia coli. PMID:18212109 CTX-M-42 CTX-M-43 is a beta-lactamase found in Pseudomonas aeruginosa and Acinetobacter spp. CTX-M-43 antibiotic_resistance ARO:3001905 CTX-M-43 ARO:3001905 CTX-M-43 is a beta-lactamase found in Pseudomonas aeruginosa and Acinetobacter spp. PMID:16510850 CTX-M-43 CTX-M-44 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-44 Toho-1 antibiotic_resistance ARO:3001906 CTX-M-44 ARO:3001906 CTX-M-44 is a beta-lactamase found in the Enterobacteriaceae family. PMID:21078949 CTX-M-44 CTX-M-45 is a beta-lactamase found in Escherichia coli. CTX-M-45 Toho-2 antibiotic_resistance ARO:3001907 CTX-M-45 ARO:3001907 CTX-M-45 is a beta-lactamase found in Escherichia coli. PMID:9593147 CTX-M-45 CTX-M-46 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-46 antibiotic_resistance ARO:3001908 CTX-M-46 ARO:3001908 CTX-M-46 is a beta-lactamase found in the Enterobacteriaceae family. PMID:16082008 CTX-M-46 CTX-M-47 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-47 antibiotic_resistance ARO:3001909 CTX-M-47 ARO:3001909 CTX-M-47 is a beta-lactamase found in the Enterobacteriaceae family. PMID:16082008 CTX-M-47 CTX-M-48 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-48 antibiotic_resistance ARO:3001910 CTX-M-48 ARO:3001910 CTX-M-48 is a beta-lactamase found in the Enterobacteriaceae family. PMID:16082008 CTX-M-48 CTX-M-49 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-49 antibiotic_resistance ARO:3001911 CTX-M-49 ARO:3001911 CTX-M-49 is a beta-lactamase found in the Enterobacteriaceae family. PMID:16082008 CTX-M-49 CTX-M-50 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-50 antibiotic_resistance ARO:3001912 CTX-M-50 ARO:3001912 CTX-M-50 is a beta-lactamase found in the Enterobacteriaceae family. PMID:16082008 CTX-M-50 CTX-M-51 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-51 antibiotic_resistance ARO:3001913 CTX-M-51 ARO:3001913 CTX-M-51 CTX-M-52 is a beta-lactamase found in Escherichia coli. CTX-M-52 antibiotic_resistance ARO:3001914 CTX-M-52 ARO:3001914 CTX-M-52 is a beta-lactamase found in Escherichia coli. PMID:15736704 CTX-M-52 CTX-M-53 is a beta-lactamase found in Salmonella enterica. CTX-M-53 antibiotic_resistance ARO:3001915 CTX-M-53 ARO:3001915 CTX-M-53 is a beta-lactamase found in Salmonella enterica. PMID:19273683 CTX-M-53 CTX-M-54 is a beta-lactamase found in Klebsiella pneumoniae. CTX-M-54 antibiotic_resistance ARO:3001916 CTX-M-54 ARO:3001916 CTX-M-54 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16785225 CTX-M-54 CTX-M-55 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-55 CTX-M-57 antibiotic_resistance ARO:3001917 CTX-M-55 ARO:3001917 CTX-M-55 is a beta-lactamase found in the Enterobacteriaceae family. PMID:17449211 CTX-M-55 CTX-M-56 is a beta-lactamase found in Escherichia coli. CTX-M-56 antibiotic_resistance ARO:3001918 CTX-M-56 ARO:3001918 CTX-M-56 is a beta-lactamase found in Escherichia coli. PMID:17548490 CTX-M-56 CTX-M-58 is a beta-lactamase found in Escherichia coli. CTX-M-58 antibiotic_resistance ARO:3001919 CTX-M-58 ARO:3001919 CTX-M-58 is a beta-lactamase found in Escherichia coli. PMID:21788458 CTX-M-58 CTX-M-59 is a beta-lactamase found in Klebsiella pneumoniae. CTX-M-59 antibiotic_resistance ARO:3001920 CTX-M-59 ARO:3001920 CTX-M-59 is a beta-lactamase found in Klebsiella pneumoniae. PMID:18347108 CTX-M-59 CTX-M-60 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-60 antibiotic_resistance ARO:3001921 CTX-M-60 ARO:3001921 CTX-M-60 CTX-M-61 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-61 antibiotic_resistance ARO:3001922 CTX-M-61 ARO:3001922 CTX-M-61 is a beta-lactamase found in the Enterobacteriaceae family. PMID:17804424 CTX-M-61 CTX-M-62 is a beta-lactamase found in Escherichia coli. CTX-M-62 antibiotic_resistance ARO:3001923 CTX-M-62 ARO:3001923 CTX-M-62 is a beta-lactamase found in Escherichia coli. PMID:18725449 CTX-M-62 CTX-M-63 is a beta-lactamase found in Salmonella enterica. CTX-M-63 antibiotic_resistance ARO:3001924 CTX-M-63 ARO:3001924 CTX-M-63 is a beta-lactamase found in Salmonella enterica. PMID:21034262 CTX-M-63 CTX-M-64 is a beta-lactamase found in Shigella sonnei. CTX-M-64 antibiotic_resistance ARO:3001925 CTX-M-64 ARO:3001925 CTX-M-64 is a beta-lactamase found in Shigella sonnei. PMID:18955524 CTX-M-64 CTX-M-65 is a beta-lactamase found in Escherichia coli. CTX-M-65 antibiotic_resistance ARO:3001926 CTX-M-65 ARO:3001926 CTX-M-65 is a beta-lactamase found in Escherichia coli. PMID:18195064 CTX-M-65 CTX-M-66 is a beta-lactamase found in Proteus mirabilis. CTX-M-66 antibiotic_resistance ARO:3001927 CTX-M-66 ARO:3001927 CTX-M-66 is a beta-lactamase found in Proteus mirabilis. PMID:17913434 CTX-M-66 CTX-M-67 is a beta-lactamase found in Escherichia coli. CTX-M-67 antibiotic_resistance ARO:3001928 CTX-M-67 ARO:3001928 CTX-M-67 is a beta-lactamase found in Escherichia coli. PMID:18775649 CTX-M-67 CTX-M-68 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-68 antibiotic_resistance ARO:3001929 CTX-M-68 ARO:3001929 CTX-M-68 is a beta-lactamase found in the Enterobacteriaceae family. PMID:19748232 CTX-M-68 CTX-M-69 is a beta-lactamase found in Escherichia coli. CTX-M-69 antibiotic_resistance ARO:3001930 CTX-M-69 ARO:3001930 CTX-M-69 is a beta-lactamase found in Escherichia coli. PMID:21940649 CTX-M-69 CTX-M-70 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001931 CTX-M-70 ARO:3001931 CTX-M-71 is a beta-lactamase found in Klebsiella pneumoniae. CTX-M-71 antibiotic_resistance ARO:3001932 CTX-M-71 ARO:3001932 CTX-M-71 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19620330 CTX-M-71 CTX-M-72 is a beta-lactamase found in Klebsiella pneumoniae. CTX-M-72 antibiotic_resistance ARO:3001933 CTX-M-72 ARO:3001933 CTX-M-72 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19590148 CTX-M-72 CTX-M-73 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-73 antibiotic_resistance ARO:3001934 CTX-M-73 ARO:3001934 CTX-M-73 CTX-M-74 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-74 antibiotic_resistance ARO:3001935 CTX-M-74 ARO:3001935 CTX-M-74 is a beta-lactamase found in the Enterobacteriaceae family. PMID:19748435 CTX-M-74 CTX-M-75 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-75 antibiotic_resistance ARO:3001936 CTX-M-75 ARO:3001936 CTX-M-75 is a beta-lactamase found in the Enterobacteriaceae family. PMID:19748435 CTX-M-75 CTX-M-76 is a beta-lactamase found in Kluyvera spp. CTX-M-76 antibiotic_resistance ARO:3001937 CTX-M-76 ARO:3001937 CTX-M-76 is a beta-lactamase found in Kluyvera spp. PMID:22697133 CTX-M-76 CTX-M-77 is a beta-lactamase found in Kluyvera spp. CTX-M-77 antibiotic_resistance ARO:3001938 CTX-M-77 ARO:3001938 CTX-M-77 is a beta-lactamase found in Kluyvera spp. PMID:22697133 CTX-M-77 CTX-M-78 is a beta-lactamase found in Kluyvera georgiana. CTX-M-78 antibiotic_resistance ARO:3001939 CTX-M-78 ARO:3001939 CTX-M-78 is a beta-lactamase found in Kluyvera georgiana. PMID:20421403 CTX-M-78 CTX-M-79 is a beta-lactamase found in Escherichia coli. CTX-M-79 antibiotic_resistance ARO:3001940 CTX-M-79 ARO:3001940 CTX-M-79 is a beta-lactamase found in Escherichia coli. PMID:18772941 CTX-M-79 CTX-M-80 is a beta-lactamase found in Klebsiella pneumoniae. CTX-M-80 antibiotic_resistance ARO:3001941 CTX-M-80 ARO:3001941 CTX-M-80 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19294528 CTX-M-80 CTX-M-81 is a beta-lactamase found in Klebsiella pneumoniae. CTX-M-81 antibiotic_resistance ARO:3001942 CTX-M-81 ARO:3001942 CTX-M-81 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19294528 CTX-M-81 CTX-M-82 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-82 antibiotic_resistance ARO:3001943 CTX-M-82 ARO:3001943 CTX-M-82 is a beta-lactamase found in the Enterobacteriaceae family. PMID:19297379 CTX-M-82 CTX-M-83 is a beta-lactamase found in Salmonella enterica. CTX-M-83 antibiotic_resistance ARO:3001944 CTX-M-83 ARO:3001944 CTX-M-83 is a beta-lactamase found in Salmonella enterica. PMID:18984647 CTX-M-83 CTX-M-84 is a beta-lactamase found in Salmonella enterica. CTX-M-84 antibiotic_resistance ARO:3001945 CTX-M-84 ARO:3001945 CTX-M-84 is a beta-lactamase found in Salmonella enterica. PMID:18984647 CTX-M-84 CTX-M-86 is a beta-lactamase found in Salmonella enterica. CTX-M-86 antibiotic_resistance ARO:3001946 CTX-M-86 ARO:3001946 CTX-M-86 is a beta-lactamase found in Salmonella enterica. PMID:18984647 CTX-M-86 CTX-M-87 is a beta-lactamase found in Escherichia coli. CTX-M-87 antibiotic_resistance ARO:3001947 CTX-M-87 ARO:3001947 CTX-M-87 is a beta-lactamase found in Escherichia coli. PMID:19429759 CTX-M-87 CTX-M-88 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-88 antibiotic_resistance ARO:3001948 CTX-M-88 ARO:3001948 CTX-M-88 CTX-M-89 is a beta-lactamase found in the Enterobacteriaceae family. CTX-M-89 antibiotic_resistance ARO:3001949 CTX-M-89 ARO:3001949 CTX-M-89 is a beta-lactamase found in the Enterobacteriaceae family. PMID:19587301 CTX-M-89 CTX-M-90 is a beta-lactamase found in Proteus mirabilis. CTX-M-90 antibiotic_resistance ARO:3001950 CTX-M-90 ARO:3001950 CTX-M-90 is a beta-lactamase found in Proteus mirabilis. PMID:21282448 CTX-M-90 CTX-M-91 is a beta-lactamase found in Escherichia coli. CTX-M-91 antibiotic_resistance ARO:3001951 CTX-M-91 ARO:3001951 CTX-M-91 is a beta-lactamase found in Escherichia coli. PMID:22450980 CTX-M-91 CTX-M-92 is a beta-lactamase found in Escherichia coli. CTX-M-92 antibiotic_resistance ARO:3001952 CTX-M-92 ARO:3001952 CTX-M-92 is a beta-lactamase found in Escherichia coli. PMID:24589574 CTX-M-92 CTX-M-93 is a beta-lactamase found in Escherichia coli. CTX-M-93 antibiotic_resistance ARO:3001953 CTX-M-93 ARO:3001953 CTX-M-93 is a beta-lactamase found in Escherichia coli. PMID:21343457 CTX-M-93 CTX-M-94 is a beta-lactamase found in Escherichia coli. CTX-M-94 antibiotic_resistance ARO:3001954 CTX-M-94 ARO:3001954 CTX-M-94 is a beta-lactamase found in Escherichia coli. PMID:23050014 CTX-M-94 CTX-M-95 is a beta-lactamase found in Kluyvera spp. CTX-M-95 antibiotic_resistance ARO:3001955 CTX-M-95 ARO:3001955 CTX-M-95 is a beta-lactamase found in Kluyvera spp. PMID:22697133 CTX-M-95 CTX-M-96 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-96 antibiotic_resistance ARO:3001956 CTX-M-96 ARO:3001956 CTX-M-96 CTX-M-98 is a beta-lactamase found in Escherichia coli. CTX-M-98 antibiotic_resistance ARO:3001957 CTX-M-98 ARO:3001957 CTX-M-98 is a beta-lactamase found in Escherichia coli. PMID:22325120 CTX-M-98 CTX-M-99 is a beta-lactamase found in Klebsiella pneumoniae. CTX-M-99 antibiotic_resistance ARO:3001958 CTX-M-99 ARO:3001958 CTX-M-99 is a beta-lactamase found in Klebsiella pneumoniae. PMID:23034125 CTX-M-99 CTX-M-100 is a beta-lactamase found in Escherichia coli. CTX-M-100 antibiotic_resistance ARO:3001959 CTX-M-100 ARO:3001959 CTX-M-100 is a beta-lactamase found in Escherichia coli. PMID:23050014 CTX-M-100 CTX-M-101 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-101 antibiotic_resistance ARO:3001960 CTX-M-101 ARO:3001960 CTX-M-101 CTX-M-102 is a beta-lactamase found in Escherichia coli. CTX-M-102 antibiotic_resistance ARO:3001961 CTX-M-102 ARO:3001961 CTX-M-102 is a beta-lactamase found in Escherichia coli. PMID:22325120 CTX-M-102 CTX-M-103 is a beta-lactamase found in Escherichia coli. CTX-M-103 antibiotic_resistance ARO:3001962 CTX-M-103 ARO:3001962 CTX-M-103 is a beta-lactamase found in Escherichia coli. PMID:23926164 CTX-M-103 CTX-M-104 is a beta-lactamase found in Escherichia coli. CTX-M-104 antibiotic_resistance ARO:3001963 CTX-M-104 ARO:3001963 CTX-M-104 is a beta-lactamase found in Escherichia coli. PMID:22325120 CTX-M-104 CTX-M-105 is a beta-lactamase found in Escherichia coli. CTX-M-105 antibiotic_resistance ARO:3001965 CTX-M-105 ARO:3001965 CTX-M-105 is a beta-lactamase found in Escherichia coli. PMID:22407683 CTX-M-105 CTX-M-106 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-106 antibiotic_resistance ARO:3001966 CTX-M-106 ARO:3001966 CTX-M-106 CTX-M-107 is a beta-lactamase found in Shigella spp. CTX-M-107 antibiotic_resistance ARO:3001967 CTX-M-107 ARO:3001967 CTX-M-107 is a beta-lactamase found in Shigella spp. PMID:21859815 CTX-M-107 CTX-M-108 is a beta-lactamase found in Shigella spp. CTX-M-108 antibiotic_resistance ARO:3001968 CTX-M-108 ARO:3001968 CTX-M-108 is a beta-lactamase found in Shigella spp. PMID:21859815 CTX-M-108 CTX-M-109 is a beta-lactamase found in Shigella spp. CTX-M-109 antibiotic_resistance ARO:3001969 CTX-M-109 ARO:3001969 CTX-M-109 is a beta-lactamase found in Shigella spp. PMID:21859815 CTX-M-109 CTX-M-110 is a beta-lactamase found in Shigella spp. CTX-M-110 antibiotic_resistance ARO:3001970 CTX-M-110 ARO:3001970 CTX-M-110 is a beta-lactamase found in Shigella spp. PMID:21859815 CTX-M-110 CTX-M-111 is a beta-lactamase found in Shigella spp. CTX-M-111 antibiotic_resistance ARO:3001971 CTX-M-111 ARO:3001971 CTX-M-111 is a beta-lactamase found in Shigella spp. PMID:21859815 CTX-M-111 CTX-M-112 is a beta-lactamase found in Shigella spp. CTX-M-112 antibiotic_resistance ARO:3001972 CTX-M-112 ARO:3001972 CTX-M-112 is a beta-lactamase found in Shigella spp. PMID:21859815 CTX-M-112 CTX-M-113 is a beta-lactamase found in Shigella spp. CTX-M-113 antibiotic_resistance ARO:3001973 CTX-M-113 ARO:3001973 CTX-M-113 is a beta-lactamase found in Shigella spp. PMID:21859815 CTX-M-113 CTX-M-114 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-114 antibiotic_resistance ARO:3001974 CTX-M-114 ARO:3001974 CTX-M-114 CTX-M-115 is a beta-lactamase found in Acinetobacter baumannii. CTX-M-115 antibiotic_resistance ARO:3001975 CTX-M-115 ARO:3001975 CTX-M-115 is a beta-lactamase found in Acinetobacter baumannii. PMID:23982021 CTX-M-115 CTX-M-116 is a beta-lactamase found in Proteus mirabilis. CTX-M-116 antibiotic_resistance ARO:3001976 CTX-M-116 ARO:3001976 CTX-M-116 is a beta-lactamase found in Proteus mirabilis. PMID:23318795 CTX-M-116 CTX-M-117 is a beta-lactamase found in Escherichia coli. CTX-M-117 antibiotic_resistance ARO:3001977 CTX-M-117 ARO:3001977 CTX-M-117 is a beta-lactamase found in Escherichia coli. PMID:23127481 CTX-M-117 CTX-M-119 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001978 CTX-M-119 ARO:3001978 CTX-M-120 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001979 CTX-M-120 ARO:3001979 CTX-M-121 is a beta-lactamase found in Escherichia coli. CTX-M-121 antibiotic_resistance ARO:3001980 CTX-M-121 ARO:3001980 CTX-M-121 is a beta-lactamase found in Escherichia coli. PMID:23892737 CTX-M-121 CTX-M-122 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-122 antibiotic_resistance ARO:3001981 CTX-M-122 ARO:3001981 CTX-M-122 CTX-M-123 is a beta-lactamase found in Escherichia coli. CTX-M-123 antibiotic_resistance ARO:3001982 CTX-M-123 ARO:3001982 CTX-M-123 is a beta-lactamase found in Escherichia coli. PMID:23752509 CTX-M-123 CTX-M-124 is a beta-lactamase found in Escherichia coli. CTX-M-124 antibiotic_resistance ARO:3001983 CTX-M-124 ARO:3001983 CTX-M-124 is a beta-lactamase found in Escherichia coli. PMID:22314536 CTX-M-124 CTX-M-125 is a beta-lactamase found in Escherichia coli. CTX-M-125 antibiotic_resistance ARO:3001984 CTX-M-125 ARO:3001984 CTX-M-125 is a beta-lactamase found in Escherichia coli. PMID:24040123 CTX-M-125 CTX-M-126 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-126 antibiotic_resistance ARO:3001985 CTX-M-126 ARO:3001985 CTX-M-126 CTX-M-127 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-127 antibiotic_resistance ARO:3001986 CTX-M-127 ARO:3001986 CTX-M-127 CTX-M-128 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3001987 CTX-M-128 ARO:3001987 CTX-M-129 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-129 antibiotic_resistance ARO:3001988 CTX-M-129 ARO:3001988 CTX-M-129 CTX-M-130 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-130 antibiotic_resistance ARO:3001989 CTX-M-130 ARO:3001989 CTX-M-130 CTX-M-131 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-131 antibiotic_resistance ARO:3001990 CTX-M-131 ARO:3001990 CTX-M-131 CTX-M-132 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-132 antibiotic_resistance ARO:3001991 CTX-M-132 ARO:3001991 CTX-M-132 CTX-M-134 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-134 antibiotic_resistance ARO:3001992 CTX-M-134 ARO:3001992 CTX-M-134 The beta-lactamase name CTX-M-135 has been depreciated. antibiotic_resistance ARO:3001993 CTX-M-135 ARO:3001993 CTX-M-137 is a beta-lactamase found in Escherichia coli. CTX-M-137 antibiotic_resistance ARO:3001994 CTX-M-137 ARO:3001994 CTX-M-137 CTX-M-136 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-136 antibiotic_resistance ARO:3001995 CTX-M-136 ARO:3001995 CTX-M-136 CTX-M-138 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-138 antibiotic_resistance ARO:3001996 CTX-M-138 ARO:3001996 CTX-M-138 CTX-M-139 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-139 antibiotic_resistance ARO:3001997 CTX-M-139 ARO:3001997 CTX-M-139 CTX-M-140 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-140 antibiotic_resistance ARO:3001998 CTX-M-140 ARO:3001998 CTX-M-140 CTX-M-141 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-141 antibiotic_resistance ARO:3001999 CTX-M-141 ARO:3001999 CTX-M-141 CTX-M-142 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-142 antibiotic_resistance ARO:3002000 CTX-M-142 ARO:3002000 CTX-M-142 CTX-M-143 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-143 antibiotic_resistance ARO:3002001 CTX-M-143 ARO:3002001 CTX-M-143 CTX-M-144 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-144 antibiotic_resistance ARO:3002002 CTX-M-144 ARO:3002002 CTX-M-144 CTX-M-145 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3002003 CTX-M-145 ARO:3002003 CTX-M-146 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-146 antibiotic_resistance ARO:3002004 CTX-M-146 ARO:3002004 CTX-M-146 CTX-M-147 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-147 antibiotic_resistance ARO:3002005 CTX-M-147 ARO:3002005 CTX-M-147 CTX-M-148 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-148 antibiotic_resistance ARO:3002006 CTX-M-148 ARO:3002006 CTX-M-148 CTX-M-150 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-150 antibiotic_resistance ARO:3002007 CTX-M-150 ARO:3002007 CTX-M-150 CTX-M-151 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-151 antibiotic_resistance ARO:3002008 CTX-M-151 ARO:3002008 CTX-M-151 CTX-M-152 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-152 antibiotic_resistance ARO:3002009 CTX-M-152 ARO:3002009 CTX-M-152 CTX-M-153 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-153 antibiotic_resistance ARO:3002010 CTX-M-153 ARO:3002010 CTX-M-153 CTX-M-154 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-154 antibiotic_resistance ARO:3002011 CTX-M-154 ARO:3002011 CTX-M-154 CMY-1 is a beta-lactamase found in the Enterobacteriaceae family. CMY-1 antibiotic_resistance ARO:3002012 CMY-1 ARO:3002012 CMY-1 is a beta-lactamase found in the Enterobacteriaceae family. PMID:8843306 CMY-1 CMY-2 is a beta-lactamase found in Klebsiella pneumoniae. BIL-1, LAT-2 CMY-2 antibiotic_resistance ARO:3002013 CMY-2 ARO:3002013 CMY-2 is a beta-lactamase found in Klebsiella pneumoniae. PMID:33416461 PMID:8787910 CMY-2 CMY-3 is a beta-lactamase found in Proteus mirabilis. Sequence data unavailable. antibiotic_resistance ARO:3002014 CMY-3 ARO:3002014 CMY-3 is a beta-lactamase found in Proteus mirabilis. Sequence data unavailable. PMID:9593136 CMY-4 is a beta-lactamase found in Proteus mirabilis. CMY-4 antibiotic_resistance ARO:3002015 CMY-4 ARO:3002015 CMY-4 is a beta-lactamase found in Proteus mirabilis. PMID:9868767 CMY-4 CMY-5 is a beta-lactamase found in Klebsiella oxytoca. CMY-5 antibiotic_resistance ARO:3002016 CMY-5 ARO:3002016 CMY-5 is a beta-lactamase found in Klebsiella oxytoca. PMID:10348751 CMY-5 CMY-6 is a beta-lactamase found in Escherichia coli. CMY-6 LAT-3 antibiotic_resistance ARO:3002017 CMY-6 ARO:3002017 CMY-6 is a beta-lactamase found in Escherichia coli. PMID:9818739 CMY-6 CMY-7 is a beta-lactamase found in Salmonella typhimurium. CMY-7 antibiotic_resistance ARO:3002018 CMY-7 ARO:3002018 CMY-7 is a beta-lactamase found in Salmonella typhimurium. PMID:12039894 CMY-7 CMY-8 is a beta-lactamase found in Klebsiella pneumoniae. CMY-8 antibiotic_resistance ARO:3002019 CMY-8 ARO:3002019 CMY-8 is a beta-lactamase found in Klebsiella pneumoniae. PMID:10817689 CMY-8 CMY-9 is a beta-lactamase found in Escherichia coli. CMY-9 antibiotic_resistance ARO:3002020 CMY-9 ARO:3002020 CMY-9 is a beta-lactamase found in Escherichia coli. PMID:12121914 CMY-9 CMY-10 is a beta-lactamase found in Klebsiella aerogenes. CMY-10 antibiotic_resistance ARO:3002021 CMY-10 ARO:3002021 CMY-10 is a beta-lactamase found in Klebsiella aerogenes. PMID:12969288 CMY-10 CMY-11 is a beta-lactamase found in Escherichia coli. CMY-11 antibiotic_resistance ARO:3002022 CMY-11 ARO:3002022 CMY-11 is a beta-lactamase found in Escherichia coli. PMID:11815567 CMY-11 CMY-12 is a beta-lactamase found in the Enterobacteriaceae family. CMY-12 antibiotic_resistance ARO:3002023 CMY-12 ARO:3002023 CMY-12 is a beta-lactamase found in the Enterobacteriaceae family. PMID:12407124 CMY-12 CMY-13 is a beta-lactamase found in Escherichia coli. CMY-13 antibiotic_resistance ARO:3002024 CMY-13 ARO:3002024 CMY-13 is a beta-lactamase found in Escherichia coli. PMID:15273143 CMY-13 CMY-14 is a beta-lactamase found in Proteus mirabilis. CMY-14 antibiotic_resistance ARO:3002025 CMY-14 ARO:3002025 CMY-14 is a beta-lactamase found in Proteus mirabilis. PMID:15504832 CMY-14 CMY-15 is a beta-lactamase found in Proteus mirabilis. CMY-15 antibiotic_resistance ARO:3002026 CMY-15 ARO:3002026 CMY-15 is a beta-lactamase found in Proteus mirabilis. PMID:15504832 CMY-15 CMY-16 is a beta-lactamase found in Proteus mirabilis. CMY-16 antibiotic_resistance ARO:3002027 CMY-16 ARO:3002027 CMY-16 is a beta-lactamase found in Proteus mirabilis. PMID:16436718 CMY-16 CMY-17 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-17 antibiotic_resistance ARO:3002028 CMY-17 ARO:3002028 CMY-17 CMY-18 is a beta-lactamase found in the Enterobacteriaceae family. CMY-18 antibiotic_resistance ARO:3002029 CMY-18 ARO:3002029 CMY-18 is a beta-lactamase found in the Enterobacteriaceae family. PMID:16584308 CMY-18 CMY-19 is a beta-lactamase found in Klebsiella pneumoniae. CMY-19 antibiotic_resistance ARO:3002030 CMY-19 ARO:3002030 CMY-19 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16436707 CMY-19 CMY-20 is a beta-lactamase found in Escherichia coli. CMY-20 antibiotic_resistance ARO:3002031 CMY-20 ARO:3002031 CMY-20 is a beta-lactamase found in Escherichia coli. PMID:18207348 CMY-20 CMY-21 is a beta-lactamase found in Escherichia coli. CMY-21 antibiotic_resistance ARO:3002032 CMY-21 ARO:3002032 CMY-21 is a beta-lactamase found in Escherichia coli. PMID:16716570 CMY-21 CMY-22 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-22 antibiotic_resistance ARO:3002033 CMY-22 ARO:3002033 CMY-22 CMY-23 is a beta-lactamase found in the Enterobacteriaceae family. CMY-23 antibiotic_resistance ARO:3002034 CMY-23 ARO:3002034 CMY-23 is a beta-lactamase found in the Enterobacteriaceae family. PMID:17110393 CMY-23 CMY-24 is a beta-lactamase found in the Enterobacteriaceae family. CMY-24 antibiotic_resistance ARO:3002035 CMY-24 ARO:3002035 CMY-24 is a beta-lactamase found in the Enterobacteriaceae family. PMID:17587551 CMY-24 CMY-25 is a beta-lactamase found in the Enterobacteriaceae family. CMY-25 antibiotic_resistance ARO:3002036 CMY-25 ARO:3002036 CMY-25 is a beta-lactamase found in the Enterobacteriaceae family. PMID:19523051 CMY-25 CMY-26 is a beta-lactamase found in the Enterobacteriaceae family. CMY-26 antibiotic_resistance ARO:3002037 CMY-26 ARO:3002037 CMY-26 is a beta-lactamase found in the Enterobacteriaceae family. PMID:17720829 CMY-26 CMY-27 is a beta-lactamase found in the Enterobacteriaceae family. CMY-27 antibiotic_resistance ARO:3002038 CMY-27 ARO:3002038 CMY-27 is a beta-lactamase found in the Enterobacteriaceae family. PMID:19523051 CMY-27 CMY-28 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-28 antibiotic_resistance ARO:3002039 CMY-28 ARO:3002039 CMY-28 CMY-29 is a beta-lactamase found in the Enterobacteriaceae family. CMY-29 antibiotic_resistance ARO:3002040 CMY-29 ARO:3002040 CMY-29 is a beta-lactamase found in the Enterobacteriaceae family. PMID:19414570 CMY-29 CMY-30 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-30 antibiotic_resistance ARO:3002041 CMY-30 ARO:3002041 CMY-30 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. PMID:19414570 CMY-30 CMY-31 is a beta-lactamase found in the Enterobacteriaceae family. CMY-31 antibiotic_resistance ARO:3002042 CMY-31 ARO:3002042 CMY-31 is a beta-lactamase found in the Enterobacteriaceae family. PMID:18065410 CMY-31 CMY-32 is a beta-lactamase found in Escherichia coli. CMY-32 antibiotic_resistance ARO:3002043 CMY-32 ARO:3002043 CMY-32 is a beta-lactamase found in Escherichia coli. PMID:19687234 CMY-32 CMY-33 is a beta-lactamase found in Escherichia coli. CMY-33 antibiotic_resistance ARO:3002044 CMY-33 ARO:3002044 CMY-33 is a beta-lactamase found in Escherichia coli. PMID:19414578 CMY-33 CMY-34 is a beta-lactamase found in Escherichia coli. CMY-34 antibiotic_resistance ARO:3002045 CMY-34 ARO:3002045 CMY-34 is a beta-lactamase found in Escherichia coli. PMID:21820821 CMY-34 CMY-35 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-35 antibiotic_resistance ARO:3002046 CMY-35 ARO:3002046 CMY-35 CMY-36 is a beta-lactamase found in Klebsiella pneumoniae. CMY-36 antibiotic_resistance ARO:3002047 CMY-36 ARO:3002047 CMY-36 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19104021 CMY-36 CMY-37 is a beta-lactamase found in Citrobacter freundii. CMY-37 antibiotic_resistance ARO:3002048 CMY-37 ARO:3002048 CMY-37 is a beta-lactamase found in Citrobacter freundii. PMID:18619820 CMY-37 CMY-38 is a beta-lactamase found in the Enterobacteriaceae family. CMY-38 antibiotic_resistance ARO:3002049 CMY-38 ARO:3002049 CMY-38 is a beta-lactamase found in the Enterobacteriaceae family. PMID:18458126 CMY-38 CMY-39 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-39 antibiotic_resistance ARO:3002050 CMY-39 ARO:3002050 CMY-39 CMY-40 is a beta-lactamase found in the Enterobacteriaceae family. CMY-40 antibiotic_resistance ARO:3002051 CMY-40 ARO:3002051 CMY-40 is a beta-lactamase found in the Enterobacteriaceae family. PMID:19523051 CMY-40 CMY-41 is a beta-lactamase found in the Enterobacteriaceae family. CMY-41 antibiotic_resistance ARO:3002052 CMY-41 ARO:3002052 CMY-41 is a beta-lactamase found in the Enterobacteriaceae family. PMID:19343954 CMY-41 CMY-42 is a plasmid-borne AmpC cephalosporinase gene found in Escherichia coli. CMY-42 antibiotic_resistance ARO:3002053 CMY-42 ARO:3002053 CMY-42 is a plasmid-borne AmpC cephalosporinase gene found in Escherichia coli. PMID:21388298 CMY-42 CMY-43 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-43 antibiotic_resistance ARO:3002054 CMY-43 ARO:3002054 CMY-43 CMY-44 is a beta-lactamase found in Escherichia coli. CMY-44 antibiotic_resistance ARO:3002055 CMY-44 ARO:3002055 CMY-44 is a beta-lactamase found in Escherichia coli. PMID:19414578 CMY-44 CMY-45 is a beta-lactamase found in Proteus mirabilis. CMY-45 antibiotic_resistance ARO:3002056 CMY-45 ARO:3002056 CMY-45 is a beta-lactamase found in Proteus mirabilis. PMID:21402851 CMY-45 CMY-46 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-46 antibiotic_resistance ARO:3002057 CMY-46 ARO:3002057 CMY-46 CMY-47 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-47 antibiotic_resistance ARO:3002058 CMY-47 ARO:3002058 CMY-47 CMY-48 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-48 antibiotic_resistance ARO:3002059 CMY-48 ARO:3002059 CMY-48 CMY-49 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-49 antibiotic_resistance ARO:3002060 CMY-49 ARO:3002060 CMY-49 CMY-50 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-50 antibiotic_resistance ARO:3002061 CMY-50 ARO:3002061 CMY-50 CMY-51 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-51 antibiotic_resistance ARO:3002062 CMY-51 ARO:3002062 CMY-51 CMY-52 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3002063 CMY-52 ARO:3002063 CMY-53 is a beta-lactamase found in Escherichia coli. CMY-53 antibiotic_resistance ARO:3002064 CMY-53 ARO:3002064 CMY-53 is a beta-lactamase found in Escherichia coli. PMID:21820821 CMY-53 CMY-54 is a beta-lactamase found in the Enterobacteriaceae family. CMY-54 antibiotic_resistance ARO:3002065 CMY-54 ARO:3002065 CMY-54 is a beta-lactamase found in the Enterobacteriaceae family. PMID:22956023 PMID:28665771 CMY-54 CMY-55 is a beta-lactamase found in the Enterobacteriaceae family. CMY-55 antibiotic_resistance ARO:3002066 CMY-55 ARO:3002066 CMY-55 is a beta-lactamase found in the Enterobacteriaceae family. PMID:22956023 CMY-55 CMY-56 is a beta-lactamase found in the Enterobacteriaceae family. CMY-56 antibiotic_resistance ARO:3002067 CMY-56 ARO:3002067 CMY-56 is a beta-lactamase found in the Enterobacteriaceae family. PMID:22956023 CMY-56 CMY-57 is a beta-lactamase found in the Enterobacteriaceae family. CMY-57 antibiotic_resistance ARO:3002068 CMY-57 ARO:3002068 CMY-57 is a beta-lactamase found in the Enterobacteriaceae family. PMID:22956023 CMY-57 CMY-59 is a beta-lactamase found in Shigella spp. CMY-59 antibiotic_resistance ARO:3002069 CMY-59 ARO:3002069 CMY-59 is a beta-lactamase found in Shigella spp. PMID:23825726 CMY-59 CMY-99 is a beta-lactamase found in Proteus mirabilis. CMY-99 antibiotic_resistance ARO:3002070 CMY-99 ARO:3002070 CMY-99 is a beta-lactamase found in Proteus mirabilis. PMID:24165184 CMY-99 CMY-110 is a beta-lactamase found in Escherichia coli. CMY-110 antibiotic_resistance ARO:3002071 CMY-110 ARO:3002071 CMY-110 is a beta-lactamase found in Escherichia coli. PMID:24709044 CMY-110 CMY-58 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-58 antibiotic_resistance ARO:3002072 CMY-58 ARO:3002072 CMY-58 CMY-60 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-60 antibiotic_resistance ARO:3002073 CMY-60 ARO:3002073 CMY-60 CMY-61 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-61 antibiotic_resistance ARO:3002074 CMY-61 ARO:3002074 CMY-61 CMY-62 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-62 antibiotic_resistance ARO:3002075 CMY-62 ARO:3002075 CMY-62 CMY-63 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-63 antibiotic_resistance ARO:3002076 CMY-63 ARO:3002076 CMY-63 CMY-64 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-64 antibiotic_resistance ARO:3002077 CMY-64 ARO:3002077 CMY-64 CMY-65 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-65 antibiotic_resistance ARO:3002078 CMY-65 ARO:3002078 CMY-65 CMY-66 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-66 antibiotic_resistance ARO:3002079 CMY-66 ARO:3002079 CMY-66 CMY-67 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-67 antibiotic_resistance ARO:3002080 CMY-67 ARO:3002080 CMY-67 CMY-68 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-68 antibiotic_resistance ARO:3002081 CMY-68 ARO:3002081 CMY-68 CMY-69 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-69 antibiotic_resistance ARO:3002082 CMY-69 ARO:3002082 CMY-69 CMY-70 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-70 antibiotic_resistance ARO:3002083 CMY-70 ARO:3002083 CMY-70 CMY-71 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-71 antibiotic_resistance ARO:3002084 CMY-71 ARO:3002084 CMY-71 CMY-72 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-72 antibiotic_resistance ARO:3002085 CMY-72 ARO:3002085 CMY-72 CMY-73 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-73 antibiotic_resistance ARO:3002086 CMY-73 ARO:3002086 CMY-73 CMY-74 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-74 antibiotic_resistance ARO:3002087 CMY-74 ARO:3002087 CMY-74 CMY-75 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-75 antibiotic_resistance ARO:3002088 CMY-75 ARO:3002088 CMY-75 CMY-76 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-76 antibiotic_resistance ARO:3002089 CMY-76 ARO:3002089 CMY-76 CMY-77 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-77 antibiotic_resistance ARO:3002090 CMY-77 ARO:3002090 CMY-77 CMY-78 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-78 antibiotic_resistance ARO:3002091 CMY-78 ARO:3002091 CMY-78 CMY-79 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-79 antibiotic_resistance ARO:3002092 CMY-79 ARO:3002092 CMY-79 CMY-80 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-80 antibiotic_resistance ARO:3002093 CMY-80 ARO:3002093 CMY-80 CMY-81 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-81 antibiotic_resistance ARO:3002094 CMY-81 ARO:3002094 CMY-81 CMY-82 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-82 antibiotic_resistance ARO:3002095 CMY-82 ARO:3002095 CMY-82 CMY-83 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-83 antibiotic_resistance ARO:3002096 CMY-83 ARO:3002096 CMY-83 CMY-84 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-84 antibiotic_resistance ARO:3002097 CMY-84 ARO:3002097 CMY-84 CMY-85 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-85 antibiotic_resistance ARO:3002098 CMY-85 ARO:3002098 CMY-85 CMY-86 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-86 antibiotic_resistance ARO:3002099 CMY-86 ARO:3002099 CMY-86 CMY-87 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-87 antibiotic_resistance ARO:3002100 CMY-87 ARO:3002100 CMY-87 CMY-88 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3002101 CMY-88 ARO:3002101 CMY-89 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. CMY-89 antibiotic_resistance ARO:3002102 CMY-89 ARO:3002102 CMY-89 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. PMID:24267783 CMY-89 CMY-90 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-90 antibiotic_resistance ARO:3002103 CMY-90 ARO:3002103 CMY-90 CMY-91 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3002104 CMY-91 ARO:3002104 CMY-92 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3002105 CMY-92 ARO:3002105 CMY-93 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-93 antibiotic_resistance ARO:3002106 CMY-93 ARO:3002106 CMY-93 CMY-94 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-94 antibiotic_resistance ARO:3002107 CMY-94 ARO:3002107 CMY-94 CMY-95 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-95 antibiotic_resistance ARO:3002108 CMY-95 ARO:3002108 CMY-95 CMY-96 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. CMY-96 antibiotic_resistance ARO:3002109 CMY-96 ARO:3002109 CMY-96 CMY-97 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. CMY-97 antibiotic_resistance ARO:3002110 CMY-97 ARO:3002110 CMY-97 CMY-98 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-98 antibiotic_resistance ARO:3002111 CMY-98 ARO:3002111 CMY-98 CMY-100 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-100 antibiotic_resistance ARO:3002112 CMY-100 ARO:3002112 CMY-100 CMY-101 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-101 antibiotic_resistance ARO:3002113 CMY-101 ARO:3002113 CMY-101 CMY-102 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-102 antibiotic_resistance ARO:3002114 CMY-102 ARO:3002114 CMY-102 CMY-103 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-103 antibiotic_resistance ARO:3002115 CMY-103 ARO:3002115 CMY-103 CMY-104 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-104 antibiotic_resistance ARO:3002116 CMY-104 ARO:3002116 CMY-104 CMY-105 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-105 antibiotic_resistance ARO:3002117 CMY-105 ARO:3002117 CMY-105 CMY-106 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-106 antibiotic_resistance ARO:3002118 CMY-106 ARO:3002118 CMY-106 CMY-107 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. CMY-107 antibiotic_resistance ARO:3002119 CMY-107 ARO:3002119 CMY-107 CMY-108 is a beta-lactamase present in plasmids of clinical Escherichia coli from humans and companion animals in the upper Midwestern USA . Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-108 antibiotic_resistance ARO:3002120 CMY-108 ARO:3002120 CMY-108 is a beta-lactamase present in plasmids of clinical Escherichia coli from humans and companion animals in the upper Midwestern USA . Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. PMID:24500191 CMY-108 CMY-109 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-109 antibiotic_resistance ARO:3002121 CMY-109 ARO:3002121 CMY-109 CMY-111 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-111 antibiotic_resistance ARO:3002122 CMY-111 ARO:3002122 CMY-111 CMY-112 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-112 antibiotic_resistance ARO:3002123 CMY-112 ARO:3002123 CMY-112 CMY-113 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-113 antibiotic_resistance ARO:3002124 CMY-113 ARO:3002124 CMY-113 CMY-114 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-114 antibiotic_resistance ARO:3002125 CMY-114 ARO:3002125 CMY-114 CMY-115 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-115 antibiotic_resistance ARO:3002126 CMY-115 ARO:3002126 CMY-115 CMY-116 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-116 antibiotic_resistance ARO:3002127 CMY-116 ARO:3002127 CMY-116 CMY-117 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-117 antibiotic_resistance ARO:3002128 CMY-117 ARO:3002128 CMY-117 CMY-118 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-118 antibiotic_resistance ARO:3002129 CMY-118 ARO:3002129 CMY-118 CMY-119 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-119 antibiotic_resistance ARO:3002130 CMY-119 ARO:3002130 CMY-119 CMY-120 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3002131 CMY-120 ARO:3002131 DHA-1 is a class C beta-lactamase found in Morganella morganii and Salmonella enterica. DHA-1 antibiotic_resistance ARO:3002132 DHA-1 ARO:3002132 DHA-1 is a class C beta-lactamase found in Morganella morganii and Salmonella enterica. PMID:9736562 DHA-1 DHA-2 is a beta-lactamase found in Klebsiella pneumoniae. DHA-2 antibiotic_resistance ARO:3002133 DHA-2 ARO:3002133 DHA-2 is a beta-lactamase found in Klebsiella pneumoniae. PMID:11157909 DHA-2 DHA-3 is a beta-lactamase found in Klebsiella pneumoniae. DHA-3 antibiotic_resistance ARO:3002134 DHA-3 ARO:3002134 DHA-3 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16216104 DHA-3 DHA-6 is a beta-lactamase found in the Enterobacteriaceae family. DHA-6 antibiotic_resistance ARO:3002135 DHA-6 ARO:3002135 DHA-6 DHA-7 is a beta-lactamase found in the Enterobacteriaceae family. DHA-7 antibiotic_resistance ARO:3002136 DHA-7 ARO:3002136 DHA-7 DHA-4 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. DHA-4 antibiotic_resistance ARO:3002137 DHA-4 ARO:3002137 DHA-4 DHA-5 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. DHA-5 antibiotic_resistance ARO:3002138 DHA-5 ARO:3002138 DHA-5 DHA-8 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3002139 DHA-8 ARO:3002139 DHA-9 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. DHA-9 antibiotic_resistance ARO:3002140 DHA-9 ARO:3002140 DHA-9 DHA-10 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. DHA-10 antibiotic_resistance ARO:3002141 DHA-10 ARO:3002141 DHA-10 DHA-11 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3002142 DHA-11 ARO:3002142 DHA-12 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. DHA-12 antibiotic_resistance ARO:3002143 DHA-12 ARO:3002143 DHA-12 DHA-13 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. DHA-13 antibiotic_resistance ARO:3002144 DHA-13 ARO:3002144 DHA-13 DHA-14 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. DHA-14 antibiotic_resistance ARO:3002145 DHA-14 ARO:3002145 DHA-14 DHA-15 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. DHA-15 antibiotic_resistance ARO:3002146 DHA-15 ARO:3002146 DHA-15 DHA-16 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. DHA-16 antibiotic_resistance ARO:3002147 DHA-16 ARO:3002147 DHA-16 DHA-17 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. DHA-17 antibiotic_resistance ARO:3002148 DHA-17 ARO:3002148 DHA-17 DHA-18 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. DHA-18 antibiotic_resistance ARO:3002149 DHA-18 ARO:3002149 DHA-18 DHA-19 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. DHA-19 antibiotic_resistance ARO:3002150 DHA-19 ARO:3002150 DHA-19 DHA-20 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. DHA-20 antibiotic_resistance ARO:3002151 DHA-20 ARO:3002151 DHA-20 DHA-21 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. DHA-21 antibiotic_resistance ARO:3002152 DHA-21 ARO:3002152 DHA-21 DHA-22 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. DHA-22 antibiotic_resistance ARO:3002153 DHA-22 ARO:3002153 DHA-22 DHA-23 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. DHA-23 antibiotic_resistance ARO:3002154 DHA-23 ARO:3002154 DHA-23 FOX-1 is a beta-lactamase found in Klebsiella pneumoniae. FOX-1 antibiotic_resistance ARO:3002155 FOX-1 ARO:3002155 FOX-1 is a beta-lactamase found in Klebsiella pneumoniae. PMID:7811034 FOX-1 FOX-2 is a beta-lactamase found in Escherichia coli. FOX-2 antibiotic_resistance ARO:3002156 FOX-2 ARO:3002156 FOX-2 is a beta-lactamase found in Escherichia coli. PMID:9303413 FOX-2 FOX-3 is a beta-lactamase found in Klebsiella oxytoca. FOX-3 antibiotic_resistance ARO:3002157 FOX-3 ARO:3002157 FOX-3 is a beta-lactamase found in Klebsiella oxytoca. PMID:9527810 FOX-3 FOX-4 is a beta-lactamase found in Escherichia coli. FOX-4 antibiotic_resistance ARO:3002158 FOX-4 ARO:3002158 FOX-4 is a beta-lactamase found in Escherichia coli. PMID:10952615 FOX-4 FOX-5 is a beta-lactamase found in Klebsiella pneumoniae. FOX-5 FOX-6 antibiotic_resistance ARO:3002159 FOX-5 ARO:3002159 FOX-5 is a beta-lactamase found in Klebsiella pneumoniae. PMID:11600376 FOX-5 FOX-7 is a beta-lactamase found in Klebsiella pneumoniae. FOX-7 antibiotic_resistance ARO:3002160 FOX-7 ARO:3002160 FOX-7 is a beta-lactamase found in Klebsiella pneumoniae. PMID:24088849 FOX-7 FOX-8 is a beta-lactamase found in the Enterobacteriaceae family. FOX-8 antibiotic_resistance ARO:3002161 FOX-8 ARO:3002161 FOX-8 is a beta-lactamase found in the Enterobacteriaceae family. PMID:22956023 FOX-8 FOX-10 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. FOX-10 antibiotic_resistance ARO:3002162 FOX-10 ARO:3002162 FOX-10 FOX-9 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. FOX-9 antibiotic_resistance ARO:3002163 FOX-9 ARO:3002163 FOX-9 FOX-11 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3002164 FOX-11 ARO:3002164 FOX-12 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. FOX-12 antibiotic_resistance ARO:3002165 FOX-12 ARO:3002165 FOX-12 MIR-1 is a beta-lactamase found in Klebsiella pneumoniae. MIR-1 antibiotic_resistance ARO:3002166 MIR-1 ARO:3002166 MIR-1 is a beta-lactamase found in Klebsiella pneumoniae. PMID:1963529 MIR-1 MIR-4 is a beta-lactamase found in Escherichia coli. MIR-4 antibiotic_resistance ARO:3002167 MIR-4 ARO:3002167 MIR-4 is a beta-lactamase found in Escherichia coli. PMID:18781358 MIR-4 MIR-2 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. MIR-2 antibiotic_resistance ARO:3002168 MIR-2 ARO:3002168 MIR-2 MIR-3 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. MIR-3 antibiotic_resistance ARO:3002169 MIR-3 ARO:3002169 MIR-3 MIR-5 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. MIR-5 MIR-8 antibiotic_resistance ARO:3002170 MIR-5 ARO:3002170 MIR-5 MIR-6 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. MIR-6 antibiotic_resistance ARO:3002171 MIR-6 ARO:3002171 MIR-6 MIR-7 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. MIR-7 antibiotic_resistance ARO:3002172 MIR-7 ARO:3002172 MIR-7 MIR-9 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. MIR-9 antibiotic_resistance ARO:3002174 MIR-9 ARO:3002174 MIR-9 MIR-10 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. MIR-10 antibiotic_resistance ARO:3002175 MIR-10 ARO:3002175 MIR-10 MIR-11 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. MIR-11 antibiotic_resistance ARO:3002176 MIR-11 ARO:3002176 MIR-11 MIR-12 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. MIR-12 antibiotic_resistance ARO:3002177 MIR-12 ARO:3002177 MIR-12 MIR-13 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. MIR-13 antibiotic_resistance ARO:3002178 MIR-13 ARO:3002178 MIR-13 MIR-14 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. MIR-14 antibiotic_resistance ARO:3002179 MIR-14 ARO:3002179 MIR-14 MIR-15 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. MIR-15 antibiotic_resistance ARO:3002180 MIR-15 ARO:3002180 MIR-15 MIR-16 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. MIR-16 antibiotic_resistance ARO:3002181 MIR-16 ARO:3002181 MIR-16 MOX-1 is a beta-lactamase found in Klebsiella pneumoniae. MOX-1 antibiotic_resistance ARO:3002182 MOX-1 ARO:3002182 MOX-1 is a beta-lactamase found in Klebsiella pneumoniae. PMID:8112596 MOX-1 MOX-2 is a beta-lactamase found in Klebsiella pneumoniae. MOX-2 antibiotic_resistance ARO:3002183 MOX-2 ARO:3002183 MOX-2 is a beta-lactamase found in Klebsiella pneumoniae. PMID:12069985 MOX-2 MOX-4 is a beta-lactamase found in Aeromonas caviae. MOX-4 antibiotic_resistance ARO:3002184 MOX-4 ARO:3002184 MOX-4 is a beta-lactamase found in Aeromonas caviae. PMID:20339022 MOX-4 MOX-6 is a beta-lactamase found in Klebsiella pneumoniae. MOX-6 antibiotic_resistance ARO:3002185 MOX-6 ARO:3002185 MOX-6 is a beta-lactamase found in Klebsiella pneumoniae. PMID:21968366 MOX-6 MOX-3 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. MOX-3 antibiotic_resistance ARO:3002186 MOX-3 ARO:3002186 MOX-3 MOX-5 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. MOX-5 antibiotic_resistance ARO:3002188 MOX-5 ARO:3002188 MOX-5 MOX-7 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. MOX-7 antibiotic_resistance ARO:3002189 MOX-7 ARO:3002189 MOX-7 MOX-8 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. MOX-8 antibiotic_resistance ARO:3002190 MOX-8 ARO:3002190 MOX-8 MOX-9 is a beta-lactamase found in Citrobacter freundii. MOX-9 antibiotic_resistance ARO:3002191 MOX-9 ARO:3002191 MOX-9 is a beta-lactamase found in Citrobacter freundii. PMID:26126492 MOX-9 IMP-1 is a beta-lactamase found in Serratia marcescens. IMP-1 antibiotic_resistance ARO:3002192 IMP-1 ARO:3002192 IMP-1 is a beta-lactamase found in Serratia marcescens. PMID:8141584 IMP-1 IMP-2 is a beta-lactamase found in Acinetobacter baumannii. IMP-2 antibiotic_resistance ARO:3002193 IMP-2 ARO:3002193 IMP-2 is a beta-lactamase found in Acinetobacter baumannii. PMID:10770756 IMP-2 IMP-3 is a beta-lactamase found in Acinetobacter baumannii. IMP-3 met-1 antibiotic_resistance ARO:3002194 IMP-3 ARO:3002194 IMP-3 is a beta-lactamase found in Acinetobacter baumannii. PMID:10898670 IMP-3 IMP-4 is a beta-lactamase found in Acinetobacter baumannii. IMP-4 antibiotic_resistance ARO:3002195 IMP-4 ARO:3002195 IMP-4 is a beta-lactamase found in Acinetobacter baumannii. PMID:17284537 IMP-4 IMP-5 is a beta-lactamase found in Acinetobacter baumannii. IMP-5 antibiotic_resistance ARO:3002196 IMP-5 ARO:3002196 IMP-5 is a beta-lactamase found in Acinetobacter baumannii. PMID:12393197 IMP-5 IMP-6 is a beta-lactamase found in Serratia marcescens. IMP-6 antibiotic_resistance ARO:3002197 IMP-6 ARO:3002197 IMP-6 is a beta-lactamase found in Serratia marcescens. PMID:11302793 IMP-6 IMP-7 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-7 antibiotic_resistance ARO:3002198 IMP-7 ARO:3002198 IMP-7 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:11751148 IMP-7 IMP-8 is a beta-lactamase found in Klebsiella pneumoniae. IMP-47 IMP-8 antibiotic_resistance ARO:3002199 IMP-8 ARO:3002199 IMP-8 is a beta-lactamase found in Klebsiella pneumoniae. PMID:11451699 IMP-8 IMP-9 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-9 antibiotic_resistance ARO:3002200 IMP-9 ARO:3002200 IMP-9 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:16377710 IMP-9 IMP-10 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-10 antibiotic_resistance ARO:3002201 IMP-10 ARO:3002201 IMP-10 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:12019129 IMP-10 IMP-11 is a beta-lactamase found in Pseudomonas and Acinetobacter spp. IMP-11 antibiotic_resistance ARO:3002202 IMP-11 ARO:3002202 IMP-11 is a beta-lactamase found in Pseudomonas and Acinetobacter spp. PMID:21707466 IMP-11 IMP-12 is a beta-lactamase found in Pseudomonas putida. IMP-12 antibiotic_resistance ARO:3002203 IMP-12 ARO:3002203 IMP-12 is a beta-lactamase found in Pseudomonas putida. PMID:12709317 IMP-12 IMP-13 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-13 antibiotic_resistance ARO:3002204 IMP-13 ARO:3002204 IMP-13 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:12951335 IMP-13 IMP-14 is a beta-lactamase found in Pseudomonas and Acinetobacter spp. IMP-14 antibiotic_resistance ARO:3002205 IMP-14 ARO:3002205 IMP-14 is a beta-lactamase found in Pseudomonas and Acinetobacter spp. PMID:21707466 IMP-14 IMP-15 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-15 antibiotic_resistance ARO:3002206 IMP-15 ARO:3002206 IMP-15 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:18362195 IMP-15 IMP-16 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-16 antibiotic_resistance ARO:3002207 IMP-16 ARO:3002207 IMP-16 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:15561846 IMP-16 IMP-17 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. IMP-17 antibiotic_resistance ARO:3002208 IMP-17 ARO:3002208 IMP-17 IMP-18 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-18 antibiotic_resistance ARO:3002209 IMP-18 ARO:3002209 IMP-18 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:16723605 IMP-18 IMP-19 is a beta-lactamase found in Aeromonas caviae. IMP-19 antibiotic_resistance ARO:3002210 IMP-19 ARO:3002210 IMP-19 is a beta-lactamase found in Aeromonas caviae. PMID:7938180 IMP-19 IMP-20 is a beta-lactamase found in Pseudomonas and Acinetobacter spp. IMP-20 antibiotic_resistance ARO:3002211 IMP-20 ARO:3002211 IMP-20 is a beta-lactamase found in Pseudomonas and Acinetobacter spp. PMID:21707466 IMP-20 IMP-21 is a beta-lactamase found in Pseudomonas and Acinetobacter spp. IMP-21 antibiotic_resistance ARO:3002212 IMP-21 ARO:3002212 IMP-21 is a beta-lactamase found in Pseudomonas and Acinetobacter spp. PMID:21707466 IMP-21 IMP-22 is a beta-lactamase found in Pseudomonas spp. IMP-22 antibiotic_resistance ARO:3002213 IMP-22 ARO:3002213 IMP-22 is a beta-lactamase found in Pseudomonas spp. PMID:19270313 IMP-22 IMP-23 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. IMP-23 antibiotic_resistance ARO:3002214 IMP-23 ARO:3002214 IMP-23 IMP-24 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-24 antibiotic_resistance ARO:3002215 IMP-24 ARO:3002215 IMP-24 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:18804966 IMP-24 IMP-25 is a beta-lactamase found in Serratia marcescens. IMP-25 antibiotic_resistance ARO:3002216 IMP-25 ARO:3002216 IMP-25 is a beta-lactamase found in Serratia marcescens. PMID:23006757 IMP-25 IMP-26 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-26 antibiotic_resistance ARO:3002217 IMP-26 ARO:3002217 IMP-26 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:20463166 IMP-26 IMP-27 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. IMP-27 antibiotic_resistance ARO:3002218 IMP-27 ARO:3002218 IMP-27 IMP-28 is a beta-lactamase found in Klebsiella oxytoca. IMP-28 antibiotic_resistance ARO:3002219 IMP-28 ARO:3002219 IMP-28 is a beta-lactamase found in Klebsiella oxytoca. PMID:22668859 IMP-28 IMP-29 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-29 antibiotic_resistance ARO:3002220 IMP-29 ARO:3002220 IMP-29 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:22290960 IMP-29 IMP-30 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-30 antibiotic_resistance ARO:3002221 IMP-30 ARO:3002221 IMP-30 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:23836186 IMP-30 IMP-31 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. IMP-31 antibiotic_resistance ARO:3002222 IMP-31 ARO:3002222 IMP-31 IMP-32 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. IMP-32 antibiotic_resistance ARO:3002223 IMP-32 ARO:3002223 IMP-32 IMP-33 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-33 antibiotic_resistance ARO:3002224 IMP-33 ARO:3002224 IMP-33 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:24041889 IMP-33 IMP-34 is a beta-lactamase found in Klebsiella spp. IMP-34 antibiotic_resistance ARO:3002225 IMP-34 ARO:3002225 IMP-34 is a beta-lactamase found in Klebsiella spp. PMID:23541689 IMP-34 IMP-35 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-35 antibiotic_resistance ARO:3002226 IMP-35 ARO:3002226 IMP-35 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:23341129 IMP-35 IMP-36 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3002227 IMP-36 ARO:3002227 IMP-37 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. IMP-37 antibiotic_resistance ARO:3002228 IMP-37 ARO:3002228 IMP-37 IMP-38 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. IMP-38 antibiotic_resistance ARO:3002229 IMP-38 ARO:3002229 IMP-38 IMP-39 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. IMP-39 antibiotic_resistance ARO:3002230 IMP-39 ARO:3002230 IMP-39 IMP-40 is a beta-lactamase found in Pseudomonas and Acinetobacter spp. IMP-40 antibiotic_resistance ARO:3002231 IMP-40 ARO:3002231 IMP-40 is a beta-lactamase found in Pseudomonas and Acinetobacter spp. PMID:23536409 IMP-40 IMP-41 is a beta-lactamase found in Pseudomonas and Acinetobacter spp. IMP-41 antibiotic_resistance ARO:3002232 IMP-41 ARO:3002232 IMP-41 is a beta-lactamase found in Pseudomonas and Acinetobacter spp. PMID:23536409 IMP-41 IMP-42 is a beta-lactamase found in Pseudomonas and Acinetobacter spp. IMP-42 antibiotic_resistance ARO:3002233 IMP-42 ARO:3002233 IMP-42 is a beta-lactamase found in Pseudomonas and Acinetobacter spp. PMID:23536409 IMP-42 IMP-43 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-43 antibiotic_resistance ARO:3002234 IMP-43 ARO:3002234 IMP-43 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:23836174 IMP-43 IMP-44 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-44 antibiotic_resistance ARO:3002235 IMP-44 ARO:3002235 IMP-44 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:23836174 IMP-44 IMP-45 is a beta-lactamase found in Pseudomonas aeruginosa. IMP-45 antibiotic_resistance ARO:3002236 IMP-45 ARO:3002236 IMP-45 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:24777897 IMP-45 IMP-46 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. IMP-46 antibiotic_resistance ARO:3002237 IMP-46 ARO:3002237 IMP-46 IMP-48 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. IMP-48 antibiotic_resistance ARO:3002239 IMP-48 ARO:3002239 IMP-48 CARB-1 is a beta-lactamase found in Pseudomonas aeruginosa. CARB-1 PSE-4, BlaP1a antibiotic_resistance ARO:3002240 CARB-1 ARO:3002240 CARB-1 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:11959558 CARB-1 CARB-2 is a beta-lactamase found in Pseudomonas aeruginosa. CARB-2 PSE-1 antibiotic_resistance ARO:3002241 CARB-2 ARO:3002241 CARB-2 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:1804019 CARB-2 CARB-3 is a beta-lactamase found in Pseudomonas aeruginosa. CARB-3 antibiotic_resistance ARO:3002242 CARB-3 ARO:3002242 CARB-3 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:1650733 CARB-3 CARB-4 is a beta-lactamase found in Pseudomonas aeruginosa. BlaP3 CARB-4 antibiotic_resistance ARO:3002243 CARB-4 ARO:3002243 CARB-4 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:9687391 CARB-4 CARB-5 is a beta-lactamase found in Acinetobacter calcoaceticus. BlaRTG-2 CARB-5 antibiotic_resistance ARO:3002244 CARB-5 ARO:3002244 CARB-5 is a beta-lactamase found in Acinetobacter calcoaceticus. PMID:10722515 CARB-5 CARB-6 is a beta-lactamase found in Vibrio cholerae. CARB-6 antibiotic_resistance ARO:3002245 CARB-6 ARO:3002245 CARB-6 is a beta-lactamase found in Vibrio cholerae. PMID:9925522 CARB-6 CARB-7 is a beta-lactamase found in Vibrio cholerae. CARB-11, PSE-5 CARB-7 antibiotic_resistance ARO:3002246 CARB-7 ARO:3002246 CARB-7 is a beta-lactamase found in Vibrio cholerae. PMID:12069969 CARB-7 CARB-8 is a beta-lactamase found in Oligella urethralis. BlaRTG-3 CARB-8 antibiotic_resistance ARO:3002247 CARB-8 ARO:3002247 CARB-8 is a beta-lactamase found in Oligella urethralis. PMID:12709319 CARB-8 CARB-9 is a beta-lactamase found in Vibrio cholerae. CARB-9 antibiotic_resistance ARO:3002248 CARB-9 ARO:3002248 CARB-9 is a beta-lactamase found in Vibrio cholerae. PMID:15388476 CARB-9 CARB-10 is a beta-lactamase found in Acinetobacter baumannii. BlaRTG-4 CARB-10 antibiotic_resistance ARO:3002249 CARB-10 ARO:3002249 CARB-10 is a beta-lactamase found in Acinetobacter baumannii. PMID:19380596 CARB-10 CARB-12 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CARB-12 antibiotic_resistance ARO:3002250 CARB-12 ARO:3002250 CARB-12 CARB-13 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3002251 CARB-13 ARO:3002251 CARB-14 is a beta-lactamase found in Acinetobacter baumannii. BlaRTG-5 CARB-14 antibiotic_resistance ARO:3002252 CARB-14 ARO:3002252 CARB-14 is a beta-lactamase found in Acinetobacter baumannii. PMID:22633451 CARB-14 CARB-15 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3002253 CARB-15 ARO:3002253 CARB-17 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CARB-17 antibiotic_resistance ARO:3002254 CARB-17 ARO:3002254 CARB-17 CARB-16 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. BlaRTG-6 CARB-16 antibiotic_resistance ARO:3002255 CARB-16 ARO:3002255 CARB-16 IND-1 is a beta-lactamase found in Chryseobacterium indologenes. IND-1 antibiotic_resistance ARO:3002256 IND-1 ARO:3002256 IND-1 is a beta-lactamase found in Chryseobacterium indologenes. PMID:10077836 IND-1 IND-2 is a beta-lactamase found in Chryseobacterium indologenes. IND-2 antibiotic_resistance ARO:3002257 IND-2 ARO:3002257 IND-2 is a beta-lactamase found in Chryseobacterium indologenes. PMID:11036018 IND-2 IND-2a is a beta-lactamase found in Chryseobacterium indologenes. IND-13 IND-2a antibiotic_resistance ARO:3002258 IND-2a ARO:3002258 IND-2a is a beta-lactamase found in Chryseobacterium indologenes. PMID:11036018 IND-2a IND-3 is a beta-lactamase found in Chryseobacterium indologenes. IND-3 antibiotic_resistance ARO:3002259 IND-3 ARO:3002259 IND-3 is a beta-lactamase found in Chryseobacterium indologenes. PMID:11036018 IND-3 IND-4 is a beta-lactamase found in Chryseobacterium indologenes. IND-4 antibiotic_resistance ARO:3002260 IND-4 ARO:3002260 IND-4 is a beta-lactamase found in Chryseobacterium indologenes. PMID:11036018 IND-4 IND-5 is a beta-lactamase found in Chryseobacterium indologenes. IND-5 antibiotic_resistance ARO:3002261 IND-5 ARO:3002261 IND-5 is a beta-lactamase found in Chryseobacterium indologenes. PMID:17470648 IND-5 IND-6 is a beta-lactamase found in Chryseobacterium indologenes. IND-6 antibiotic_resistance ARO:3002262 IND-6 ARO:3002262 IND-6 is a beta-lactamase found in Chryseobacterium indologenes. PMID:19651915 IND-6 IND-7 is a beta-lactamase found in Chryseobacterium indologenes. IND-7 antibiotic_resistance ARO:3002263 IND-7 ARO:3002263 IND-7 is a beta-lactamase found in Chryseobacterium indologenes. PMID:20305272 IND-7 IND-8 is a beta-lactamase found in Escherichia coli. IND-8 antibiotic_resistance ARO:3002264 IND-8 ARO:3002264 IND-8 is a beta-lactamase found in Escherichia coli. PMID:3876328 IND-8 IND-9 is a beta-lactamase found in Escherichia coli. IND-9 antibiotic_resistance ARO:3002265 IND-9 ARO:3002265 IND-9 is a beta-lactamase found in Escherichia coli. PMID:3876328 IND-9 IND-10 is a beta-lactamase found in Escherichia coli. IND-10 antibiotic_resistance ARO:3002266 IND-10 ARO:3002266 IND-10 is a beta-lactamase found in Escherichia coli. PMID:3876328 IND-10 IND-11 is a beta-lactamase found in Escherichia coli. IND-11 antibiotic_resistance ARO:3002267 IND-11 ARO:3002267 IND-11 is a beta-lactamase found in Escherichia coli. PMID:3876328 IND-11 IND-12 is a beta-lactamase found in Escherichia coli. IND-12 antibiotic_resistance ARO:3002268 IND-12 ARO:3002268 IND-12 is a beta-lactamase found in Escherichia coli. PMID:3876328 IND-12 IND-14 is a beta-lactamase found in Escherichia coli. IND-14 antibiotic_resistance ARO:3002269 IND-14 ARO:3002269 IND-14 is a beta-lactamase found in Escherichia coli. PMID:3876328 IND-14 IND-15 is a beta-lactamase found in Escherichia coli. IND-15 antibiotic_resistance ARO:3002270 IND-15 ARO:3002270 IND-15 is a beta-lactamase found in Escherichia coli. PMID:3876328 IND-15 VIM-1 is a beta-lactamase found in Pseudomonas spp. VIM-1 antibiotic_resistance ARO:3002271 VIM-1 ARO:3002271 VIM-1 is a beta-lactamase found in Pseudomonas spp. PMID:10390207 VIM-1 VIM-2 is a beta-lactamase found in Pseudomonas spp. PDB:1KO2 VIM-2 antibiotic_resistance ARO:3002272 VIM-2 ARO:3002272 VIM-2 is a beta-lactamase found in Pseudomonas spp. PMID:10722487 VIM-2 VIM-3 is a beta-lactamase found in Pseudomonas spp. VIM-3 antibiotic_resistance ARO:3002273 VIM-3 ARO:3002273 VIM-3 is a beta-lactamase found in Pseudomonas spp. PMID:11451678 VIM-3 VIM-4 is a beta-lactamase found in Pseudomonas aeruginosa. VIM-4 antibiotic_resistance ARO:3002274 VIM-4 ARO:3002274 VIM-4 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:12435718 VIM-4 VIM-5 is a beta-lactamase found in Pseudomonas aeruginosa. VIM-5 antibiotic_resistance ARO:3002275 VIM-5 ARO:3002275 VIM-5 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:15190017 VIM-5 VIM-6 is a beta-lactamase found in Pseudomonas spp. VIM-6 antibiotic_resistance ARO:3002276 VIM-6 ARO:3002276 VIM-6 is a beta-lactamase found in Pseudomonas spp. PMID:15155248 VIM-6 VIM-7 is a beta-lactamase found in Pseudomonas aeruginosa. VIM-7 antibiotic_resistance ARO:3002277 VIM-7 ARO:3002277 VIM-7 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:14693560 VIM-7 VIM-8 is a beta-lactamase found in Pseudomonas aeruginosa. VIM-8 antibiotic_resistance ARO:3002278 VIM-8 ARO:3002278 VIM-8 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:15528701 VIM-8 VIM-9 is a beta-lactamase found in Pseudomonas spp. VIM-9 antibiotic_resistance ARO:3002279 VIM-9 ARO:3002279 VIM-9 is a beta-lactamase found in Pseudomonas spp. PMID:18819973 VIM-9 VIM-10 is a beta-lactamase found in Pseudomonas spp. VIM-10 antibiotic_resistance ARO:3002280 VIM-10 ARO:3002280 VIM-10 is a beta-lactamase found in Pseudomonas spp. PMID:18819973 VIM-10 VIM-11 is a beta-lactamase found in Pseudomonas aeruginosa. VIM-11 antibiotic_resistance ARO:3002281 VIM-11 ARO:3002281 VIM-11 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:15616342 VIM-11 VIM-12 is a beta-lactamase found in Klebsiella pneumoniae. VIM-12 antibiotic_resistance ARO:3002282 VIM-12 ARO:3002282 VIM-12 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304191 VIM-12 VIM-13 is a beta-lactamase found in Pseudomonas aeruginosa. VIM-13 antibiotic_resistance ARO:3002283 VIM-13 ARO:3002283 VIM-13 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:18644957 VIM-13 VIM-14 is a beta-lactamase found in Pseudomonas aeruginosa. VIM-14 antibiotic_resistance ARO:3002284 VIM-14 ARO:3002284 VIM-14 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:21521413 VIM-14 VIM-15 is a beta-lactamase found in Pseudomonas aeruginosa. VIM-15 antibiotic_resistance ARO:3002285 VIM-15 ARO:3002285 VIM-15 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:18519714 VIM-15 VIM-16 is a beta-lactamase found in Pseudomonas aeruginosa. VIM-16 antibiotic_resistance ARO:3002286 VIM-16 ARO:3002286 VIM-16 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:18519714 VIM-16 VIM-17 is a beta-lactamase found in Pseudomonas aeruginosa. VIM-17 antibiotic_resistance ARO:3002287 VIM-17 ARO:3002287 VIM-17 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:19164147 VIM-17 VIM-18 is a beta-lactamase found in Pseudomonas aeruginosa. VIM-18 antibiotic_resistance ARO:3002288 VIM-18 ARO:3002288 VIM-18 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:19114677 VIM-18 VIM-19 is a beta-lactamase found in the Enterobacteriaceae family. VIM-19 antibiotic_resistance ARO:3002289 VIM-19 ARO:3002289 VIM-19 is a beta-lactamase found in the Enterobacteriaceae family. PMID:19917750 VIM-19 VIM-20 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. VIM-20 antibiotic_resistance ARO:3002290 VIM-20 ARO:3002290 VIM-20 VIM-21 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3002291 VIM-21 ARO:3002291 VIM-22 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3002292 VIM-22 ARO:3002292 VIM-23 is a beta-lactamase found in Enterobacter cloacae. VIM-23 antibiotic_resistance ARO:3002293 VIM-23 ARO:3002293 VIM-23 is a beta-lactamase found in Enterobacter cloacae. PMID:20961909 VIM-23 VIM-24 is a beta-lactamase found in Klebsiella pneumoniae. VIM-24 antibiotic_resistance ARO:3002294 VIM-24 ARO:3002294 VIM-24 is a beta-lactamase found in Klebsiella pneumoniae. PMID:21282438 VIM-24 VIM-25 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. VIM-25 antibiotic_resistance ARO:3002295 VIM-25 ARO:3002295 VIM-25 VIM-26 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. VIM-26 antibiotic_resistance ARO:3002296 VIM-26 ARO:3002296 VIM-26 VIM-27 is a beta-lactamase found in Klebsiella pneumoniae. VIM-27 antibiotic_resistance ARO:3002297 VIM-27 ARO:3002297 VIM-27 is a beta-lactamase found in Klebsiella pneumoniae. PMID:21518835 VIM-27 VIM-28 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. VIM-28 antibiotic_resistance ARO:3002298 VIM-28 ARO:3002298 VIM-28 VIM-29 is a beta-lactamase found in the Enterobacteriaceae family. VIM-29 antibiotic_resistance ARO:3002299 VIM-29 ARO:3002299 VIM-29 is a beta-lactamase found in the Enterobacteriaceae family. PMID:23954421 VIM-29 VIM-30 is a beta-lactamase found in the Enterobacteriaceae family. VIM-30 antibiotic_resistance ARO:3002300 VIM-30 ARO:3002300 VIM-30 is a beta-lactamase found in the Enterobacteriaceae family. PMID:23658259 VIM-30 VIM-31 is a beta-lactamase found in Enterobacter cloacae. VIM-31 antibiotic_resistance ARO:3002301 VIM-31 ARO:3002301 VIM-31 is a beta-lactamase found in Enterobacter cloacae. PMID:22391550 VIM-31 VIM-32 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. VIM-32 antibiotic_resistance ARO:3002302 VIM-32 ARO:3002302 VIM-32 VIM-33 is a beta-lactamase found in Klebsiella pneumoniae. VIM-33 antibiotic_resistance ARO:3002303 VIM-33 ARO:3002303 VIM-33 is a beta-lactamase found in Klebsiella pneumoniae. PMID:23070171 VIM-33 VIM-34 is a beta-lactamase found in Klebsiella pneumoniae. VIM-34 antibiotic_resistance ARO:3002304 VIM-34 ARO:3002304 VIM-34 is a beta-lactamase found in Klebsiella pneumoniae. PMID:23934739 VIM-34 VIM-35 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. VIM-35 antibiotic_resistance ARO:3002305 VIM-35 ARO:3002305 VIM-35 VIM-36 is a beta-lactamase found in Pseudomonas aeruginosa. VIM-36 antibiotic_resistance ARO:3002306 VIM-36 ARO:3002306 VIM-36 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:24603963 VIM-36 VIM-37 is a beta-lactamase found in Pseudomonas aeruginosa. VIM-37 antibiotic_resistance ARO:3002307 VIM-37 ARO:3002307 VIM-37 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:24603963 VIM-37 VIM-38 is a beta-lactamase found in Pseudomonas aeruginosa. VIM-38 antibiotic_resistance ARO:3002308 VIM-38 ARO:3002308 VIM-38 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:24428980 VIM-38 VIM-39 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. VIM-39 antibiotic_resistance ARO:3002309 VIM-39 ARO:3002309 VIM-39 VIM-40 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. VIM-40 antibiotic_resistance ARO:3002310 VIM-40 ARO:3002310 VIM-40 VIM-41 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. VIM-41 antibiotic_resistance ARO:3002311 VIM-41 ARO:3002311 VIM-41 KPC-2 is a beta-lactamase found in Klebsiella pneumoniae and Pseudomonas aeruginosa. PDB:2OV5 KPC-1 KPC-2 antibiotic_resistance ARO:3002312 KPC-2 ARO:3002312 KPC-2 is a beta-lactamase found in Klebsiella pneumoniae and Pseudomonas aeruginosa. PMID:12615876 PMID:17261621 KPC-2 KPC-3 is a beta-lactamase found in Klebsiella pneumoniae. KPC-3 antibiotic_resistance ARO:3002313 KPC-3 ARO:3002313 KPC-3 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19015357 KPC-3 KPC-4 is a beta-lactamase found in Klebsiella pneumoniae. KPC-4 antibiotic_resistance ARO:3002314 KPC-4 ARO:3002314 KPC-4 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19015357 KPC-4 KPC-5 is a beta-lactamase found in Klebsiella pneumoniae and Pseudomonas aeruginosa. KPC-5 antibiotic_resistance ARO:3002315 KPC-5 ARO:3002315 KPC-5 is a beta-lactamase found in Klebsiella pneumoniae and Pseudomonas aeruginosa. PMID:19015357 KPC-5 KPC-6 is a beta-lactamase found in Klebsiella pneumoniae. KPC-6 antibiotic_resistance ARO:3002316 KPC-6 ARO:3002316 KPC-6 is a beta-lactamase found in Klebsiella pneumoniae. PMID:22908150 KPC-6 KPC-7 is a beta-lactamase found in Klebsiella pneumoniae. KPC-7 antibiotic_resistance ARO:3002317 KPC-7 ARO:3002317 KPC-7 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19036932 KPC-7 KPC-8 is a beta-lactamase found in Klebsiella pneumoniae. KPC-8 antibiotic_resistance ARO:3002318 KPC-8 ARO:3002318 KPC-8 is a beta-lactamase found in Klebsiella pneumoniae. PMID:20334553 KPC-8 KPC-9 is a beta-lactamase found in Klebsiella pneumoniae. KPC-9 antibiotic_resistance ARO:3002319 KPC-9 ARO:3002319 KPC-9 is a beta-lactamase found in Klebsiella pneumoniae. PMID:22964247 KPC-9 KPC-10 is a beta-lactamase found in Klebsiella pneumoniae. KPC-10 antibiotic_resistance ARO:3002320 KPC-10 ARO:3002320 KPC-10 is a beta-lactamase found in Klebsiella pneumoniae. PMID:20038618 KPC-10 KPC-11 is a beta-lactamase found in Klebsiella pneumoniae. KPC-11 antibiotic_resistance ARO:3002321 KPC-11 ARO:3002321 KPC-11 is a beta-lactamase found in Klebsiella pneumoniae. PMID:22322349 KPC-11 KPC-12 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. KPC-12 antibiotic_resistance ARO:3002322 KPC-12 ARO:3002322 KPC-12 KPC-13 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. KPC-13 antibiotic_resistance ARO:3002323 KPC-13 ARO:3002323 KPC-13 KPC-14 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. KPC-14 antibiotic_resistance ARO:3002324 KPC-14 ARO:3002324 KPC-14 KPC-15 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. KPC-15 antibiotic_resistance ARO:3002325 KPC-15 ARO:3002325 KPC-15 KPC-16 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. KPC-16 antibiotic_resistance ARO:3002326 KPC-16 ARO:3002326 KPC-16 KPC-17 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. KPC-17 antibiotic_resistance ARO:3002327 KPC-17 ARO:3002327 KPC-17 KPC-18 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. KPC-18 antibiotic_resistance ARO:3002328 KPC-18 ARO:3002328 KPC-18 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. PMID:26719440 KPC-18 KPC-19 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. KPC-19 antibiotic_resistance ARO:3002329 KPC-19 ARO:3002329 KPC-19 GES-1 is a beta-lactamase found in Klebsiella pneumoniae. GES-1 antibiotic_resistance ARO:3002330 GES-1 ARO:3002330 GES-1 is a beta-lactamase found in Klebsiella pneumoniae. PMID:10681329 GES-1 GES-2 is a beta-lactamase found in Pseudomonas aeruginosa. GES-2 antibiotic_resistance ARO:3002331 GES-2 ARO:3002331 GES-2 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:11502535 GES-2 GES-3 is a beta-lactamase found in Klebsiella pneumoniae. GES-3 antibiotic_resistance ARO:3002332 GES-3 ARO:3002332 GES-3 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15155185 GES-3 GES-4 is a beta-lactamase found in Klebsiella pneumoniae. GES-4 antibiotic_resistance ARO:3002333 GES-4 ARO:3002333 GES-4 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15273099 GES-4 GES-5 is a beta-lactamase found in the Enterobacteriaceae family. GES-5 antibiotic_resistance ARO:3002334 GES-5 ARO:3002334 GES-5 is a beta-lactamase found in the Enterobacteriaceae family. PMID:15135524 GES-5 GES-6 is a beta-lactamase found in the Enterobacteriaceae family. GES-6 antibiotic_resistance ARO:3002335 GES-6 ARO:3002335 GES-6 is a beta-lactamase found in the Enterobacteriaceae family. PMID:15135524 GES-6 GES-7 is a beta-lactamase found in Enterobacter cloacae. GES-7 IBC-1 antibiotic_resistance ARO:3002336 GES-7 ARO:3002336 GES-7 is a beta-lactamase found in Enterobacter cloacae. PMID:10952563 GES-7 GES-8 is a beta-lactamase found in Pseudomonas aeruginosa. GES-8 IBC-2 antibiotic_resistance ARO:3002337 GES-8 ARO:3002337 GES-8 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:11679551 GES-8 GES-9 is a beta-lactamase found in Pseudomonas aeruginosa. GES-9 antibiotic_resistance ARO:3002338 GES-9 ARO:3002338 GES-9 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:16048994 GES-9 GES-10 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. GES-10 antibiotic_resistance ARO:3002339 GES-10 ARO:3002339 GES-10 GES-11 is a beta-lactamase found in Acinetobacter baumannii. GES-11 antibiotic_resistance ARO:3002340 GES-11 ARO:3002340 GES-11 is a beta-lactamase found in Acinetobacter baumannii. PMID:19451292 GES-11 GES-12 is a beta-lactamase found in Acinetobacter baumannii. GES-12 antibiotic_resistance ARO:3002341 GES-12 ARO:3002341 GES-12 is a beta-lactamase found in Acinetobacter baumannii. PMID:20805394 GES-12 GES-13 is a beta-lactamase found in Pseudomonas aeruginosa. GES-13 antibiotic_resistance ARO:3002342 GES-13 ARO:3002342 GES-13 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:20065056 GES-13 GES-14 is a beta-lactamase found in Acinetobacter baumannii. GES-14 antibiotic_resistance ARO:3002343 GES-14 ARO:3002343 GES-14 is a beta-lactamase found in Acinetobacter baumannii. PMID:20805394 GES-14 GES-15 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. GES-15 antibiotic_resistance ARO:3002344 GES-15 ARO:3002344 GES-15 GES-16 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. GES-16 antibiotic_resistance ARO:3002345 GES-16 ARO:3002345 GES-16 GES-17 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. GES-17 antibiotic_resistance ARO:3002346 GES-17 ARO:3002346 GES-17 GES-18 is a beta-lactamase found in Pseudomonas aeruginosa. GES-18 antibiotic_resistance ARO:3002347 GES-18 ARO:3002347 GES-18 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:23114760 GES-18 GES-19 is a beta-lactamase found in the Enterobacteriaceae family. GES-19 antibiotic_resistance ARO:3002348 GES-19 ARO:3002348 GES-19 is a beta-lactamase found in the Enterobacteriaceae family. PMID:22526300 GES-19 GES-20 is a beta-lactamase found in the Enterobacteriaceae family. GES-20 antibiotic_resistance ARO:3002349 GES-20 ARO:3002349 GES-20 is a beta-lactamase found in the Enterobacteriaceae family. PMID:22526300 GES-20 GES-21 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. GES-21 antibiotic_resistance ARO:3002350 GES-21 ARO:3002350 GES-21 GES-22 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. GES-22 antibiotic_resistance ARO:3002351 GES-22 ARO:3002351 GES-22 GES-23 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. GES-23 antibiotic_resistance ARO:3002352 GES-23 ARO:3002352 GES-23 GES-24 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. GES-24 antibiotic_resistance ARO:3002353 GES-24 ARO:3002353 GES-24 NDM-3 is a beta-lactamase found in the Enterobacteriaceae family. NDM-3 antibiotic_resistance ARO:3002354 NDM-3 ARO:3002354 NDM-3 is a beta-lactamase found in the Enterobacteriaceae family. PMID:23330550 NDM-3 NDM-4 is a beta-lactamase found in Escherichia coli. NDM-4 antibiotic_resistance ARO:3002355 NDM-4 ARO:3002355 NDM-4 is a beta-lactamase found in Escherichia coli. PMID:22252797 NDM-4 NDM-6 is a beta-lactamase found in the Enterobacteriaceae family. NDM-6 antibiotic_resistance ARO:3002356 NDM-6 ARO:3002356 NDM-6 is a beta-lactamase found in the Enterobacteriaceae family. PMID:22526013 NDM-6 NDM-7 is a beta-lactamase found in Escherichia coli. NDM-7 antibiotic_resistance ARO:3002357 NDM-7 ARO:3002357 NDM-7 is a beta-lactamase found in Escherichia coli. PMID:23557929 NDM-7 NDM-8 is a beta-lactamase found in Escherichia coli. NDM-8 antibiotic_resistance ARO:3002358 NDM-8 ARO:3002358 NDM-8 is a beta-lactamase found in Escherichia coli. PMID:23459485 NDM-8 NDM-9 is a beta-lactamase found in Klebsiella pneumoniae. NDM-9 antibiotic_resistance ARO:3002359 NDM-9 ARO:3002359 NDM-9 is a beta-lactamase found in Klebsiella pneumoniae. PMID:24913967 NDM-9 NDM-10 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. NDM-10 antibiotic_resistance ARO:3002360 NDM-10 ARO:3002360 NDM-10 NDM-11 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. NDM-11 antibiotic_resistance ARO:3002361 NDM-11 ARO:3002361 NDM-11 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. PMID:29656053 NDM-11 NDM-12 is a beta-lactamase found in Escherichia coli. NDM-12 antibiotic_resistance ARO:3002362 NDM-12 ARO:3002362 NDM-12 is a beta-lactamase found in Escherichia coli. PMID:25092693 NDM-12 PER-1 is a beta-lactamase found in Pseudomonas aeruginosa. PER-1 antibiotic_resistance ARO:3002363 PER-1 ARO:3002363 PER-1 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:8141562 PER-1 PER-2 is a beta-lactamase found in Salmonella typhimurium. PER-2 antibiotic_resistance ARO:3002364 PER-2 ARO:3002364 PER-2 is a beta-lactamase found in Salmonella typhimurium. PMID:8851581 PER-2 PER-3 is a beta-lactamase found in Aeromonas spp. PER-3 antibiotic_resistance ARO:3002365 PER-3 ARO:3002365 PER-3 is a beta-lactamase found in Aeromonas spp. PMID:21968366 PER-3 PER-4 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. PER-4 antibiotic_resistance ARO:3002366 PER-4 ARO:3002366 PER-4 PER-5 is a beta-lactamase found in the Enterobacteriaceae family. PER-5 antibiotic_resistance ARO:3002367 PER-5 ARO:3002367 PER-5 is a beta-lactamase found in the Enterobacteriaceae family. PMID:23284886 PER-5 PER-6 is a beta-lactamase found in Aeromonas allosaccharophila. PER-6 antibiotic_resistance ARO:3002368 PER-6 ARO:3002368 PER-6 is a beta-lactamase found in Aeromonas allosaccharophila. PMID:20145085 PER-6 PER-7 is a beta-lactamase found in Acinetobacter baumannii. PER-7 antibiotic_resistance ARO:3002369 PER-7 ARO:3002369 PER-7 is a beta-lactamase found in Acinetobacter baumannii. PMID:21383087 PER-7 VEB-1 is a beta-lactamase found in Escherichia coli and Pseudomonas aeruginosa. VEB-1 antibiotic_resistance ARO:3002370 VEB-1 ARO:3002370 VEB-1 is a beta-lactamase found in Escherichia coli and Pseudomonas aeruginosa. PMID:10049269 PMID:10427724 VEB-1 VEB-2 is a beta-lactamase found in Pseudomonas aeruginosa. VEB-2 antibiotic_resistance ARO:3002371 VEB-2 ARO:3002371 VEB-2 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:11807680 VEB-2 VEB-3 is a beta-lactamase found in Enterobacter cloacae. VEB-3 antibiotic_resistance ARO:3002372 VEB-3 ARO:3002372 VEB-3 is a beta-lactamase found in Enterobacter cloacae. PMID:15695687 VEB-3 VEB-4 is a beta-lactamase found in Proteus mirabilis. VEB-4 antibiotic_resistance ARO:3002373 VEB-4 ARO:3002373 VEB-4 is a beta-lactamase found in Proteus mirabilis. PMID:18292096 VEB-4 VEB-6 is a beta-lactamase found in Proteus mirabilis. VEB-6 antibiotic_resistance ARO:3002374 VEB-6 ARO:3002374 VEB-6 is a beta-lactamase found in Proteus mirabilis. PMID:18025117 VEB-6 VEB-5 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. VEB-5 antibiotic_resistance ARO:3002375 VEB-5 ARO:3002375 VEB-5 VEB-7 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. VEB-7 antibiotic_resistance ARO:3002376 VEB-7 ARO:3002376 VEB-7 VEB-8 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. VEB-8 antibiotic_resistance ARO:3002377 VEB-8 ARO:3002377 VEB-8 VEB-9 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. VEB-1a VEB-9 antibiotic_resistance ARO:3002378 VEB-9 ARO:3002378 VEB-9 SME-1 is a beta-lactamase found in Serratia marcescens. SME-1 antibiotic_resistance ARO:3002379 SME-1 ARO:3002379 SME-1 is a beta-lactamase found in Serratia marcescens. PMID:8092824 SME-1 SME-2 is a beta-lactamase found in Serratia marcescens. SME-2 antibiotic_resistance ARO:3002380 SME-2 ARO:3002380 SME-2 is a beta-lactamase found in Serratia marcescens. PMID:11036019 SME-2 SME-3 is a beta-lactamase found in Serratia marcescens. SME-3 antibiotic_resistance ARO:3002381 SME-3 ARO:3002381 SME-3 is a beta-lactamase found in Serratia marcescens. PMID:17005839 SME-3 SME-4 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. SME-4 antibiotic_resistance ARO:3002382 SME-4 ARO:3002382 SME-4 SME-5 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. SME-5 antibiotic_resistance ARO:3002383 SME-5 ARO:3002383 SME-5 BEL beta-lactamases are class A expanded-spectrum beta-lactamases that are inhibited by clavulanic acid. They are chromosomally encoded and hydrolyze most cephalosporins and aztreonam. antibiotic_resistance ARO:3002384 BEL beta-lactamase ARO:3002384 BEL beta-lactamases are class A expanded-spectrum beta-lactamases that are inhibited by clavulanic acid. They are chromosomally encoded and hydrolyze most cephalosporins and aztreonam. PMID:16127048 BEL-1 is a beta-lactamase found in Pseudomonas aeruginosa. BEL-1 antibiotic_resistance ARO:3002385 BEL-1 ARO:3002385 BEL-1 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:16127048 BEL-1 BEL-2 is a beta-lactamase found in Pseudomonas aeruginosa. BEL-2 antibiotic_resistance ARO:3002386 BEL-2 ARO:3002386 BEL-2 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:19884378 BEL-2 BEL-3 is a beta-lactamase found in Pseudomonas aeruginosa. BEL-3 antibiotic_resistance ARO:3002387 BEL-3 ARO:3002387 BEL-3 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:19933793 BEL-3 OXY beta-lactamases are chromosomal class A beta-lactamases that are found in Klebsiella oxytoca. At constitutive low levels, OXY beta-lactamases confer resistance to aminopenicillins and carboxypenicillins. At high induced levels, OXY beta-lactamases confer resistance to penicillins, cephalosporins and aztreonam. K1 KOXY antibiotic_resistance ARO:3002388 OXY beta-lactamase ARO:3002388 OXY beta-lactamases are chromosomal class A beta-lactamases that are found in Klebsiella oxytoca. At constitutive low levels, OXY beta-lactamases confer resistance to aminopenicillins and carboxypenicillins. At high induced levels, OXY beta-lactamases confer resistance to penicillins, cephalosporins and aztreonam. PMID:23090395 OXY-1-1 is a beta-lactamase found in Klebsiella oxytoca. OXY-1-1 antibiotic_resistance ARO:3002389 OXY-1-1 ARO:3002389 OXY-1-1 is a beta-lactamase found in Klebsiella oxytoca. PMID:23090395 OXY-1-1 OXY-1-2 is a beta-lactamase found in Klebsiella oxytoca. OXY-1-2 OXY-1-5 antibiotic_resistance ARO:3002390 OXY-1-2 ARO:3002390 OXY-1-2 is a beta-lactamase found in Klebsiella oxytoca. PMID:16048960 OXY-1-2 OXY-1-3 is a beta-lactamase found in Klebsiella oxytoca. OXY-1-3 antibiotic_resistance ARO:3002391 OXY-1-3 ARO:3002391 OXY-1-3 is a beta-lactamase found in Klebsiella oxytoca. PMID:12807183 OXY-1-3 OXY-1-4 is a beta-lactamase found in Klebsiella oxytoca. OXY-1-4 antibiotic_resistance ARO:3002392 OXY-1-4 ARO:3002392 OXY-1-4 is a beta-lactamase found in Klebsiella oxytoca. PMID:12807183 OXY-1-4 OXY-1-6 is a beta-lactamase found in Klebsiella oxytoca. OXY-1-6 antibiotic_resistance ARO:3002394 OXY-1-6 ARO:3002394 OXY-1-6 is a beta-lactamase found in Klebsiella oxytoca. PMID:10223957 OXY-1-6 OXY-2-1 is a beta-lactamase found in Klebsiella oxytoca. OXY-2-1 antibiotic_resistance ARO:3002396 OXY-2-1 ARO:3002396 OXY-2-1 is a beta-lactamase found in Klebsiella oxytoca. PMID:16048960 OXY-2-1 OXY-2-2 is a beta-lactamase found in Klebsiella oxytoca. OXY-2-2 antibiotic_resistance ARO:3002397 OXY-2-2 ARO:3002397 OXY-2-2 is a beta-lactamase found in Klebsiella oxytoca. PMID:16048960 OXY-2-2 OXY-2-3 is a beta-lactamase found in Klebsiella oxytoca. OXY-2-3 antibiotic_resistance ARO:3002398 OXY-2-3 ARO:3002398 OXY-2-3 is a beta-lactamase found in Klebsiella oxytoca. PMID:12807183 OXY-2-3 OXY-2-4 is a beta-lactamase found in Klebsiella oxytoca. OXY-2-4 antibiotic_resistance ARO:3002399 OXY-2-4 ARO:3002399 OXY-2-4 is a beta-lactamase found in Klebsiella oxytoca. PMID:10223957 OXY-2-4 OXY-2-5 is a beta-lactamase found in Klebsiella oxytoca. OXY-2-5 antibiotic_resistance ARO:3002400 OXY-2-5 ARO:3002400 OXY-2-5 is a beta-lactamase found in Klebsiella oxytoca. PMID:12807183 OXY-2-5 OXY-2-6 is a beta-lactamase found in Klebsiella oxytoca. OXY-2-6 antibiotic_resistance ARO:3002401 OXY-2-6 ARO:3002401 OXY-2-6 is a beta-lactamase found in Klebsiella oxytoca. PMID:12807183 OXY-2-6 OXY-2-7 is a beta-lactamase found in Klebsiella oxytoca. OXY-2-7 antibiotic_resistance ARO:3002402 OXY-2-7 ARO:3002402 OXY-2-7 is a beta-lactamase found in Klebsiella oxytoca. PMID:7574532 OXY-2-7 OXY-2-8 is a beta-lactamase found in Klebsiella oxytoca. OXY-2-8 antibiotic_resistance ARO:3002403 OXY-2-8 ARO:3002403 OXY-2-8 is a beta-lactamase found in Klebsiella oxytoca. PMID:12019142 OXY-2-8 OXY-2-9 is a beta-lactamase found in Klebsiella oxytoca. OXY-2-9 antibiotic_resistance ARO:3002404 OXY-2-9 ARO:3002404 OXY-2-9 is a beta-lactamase found in Klebsiella oxytoca. PMID:21555768 OXY-2-9 OXY-2-10 is a beta-lactamase. From the Pasteur Institute (Genopole) list of OXY beta-lactamases. OXY-2-10 antibiotic_resistance ARO:3002405 OXY-2-10 ARO:3002405 OXY-2-10 OXY-2-11 is a beta-lactamase. From the Pasteur Institute (Genopole) list of OXY beta-lactamases. OXY-2-11 antibiotic_resistance ARO:3002406 OXY-2-11 ARO:3002406 OXY-2-11 OXY-2-12 is a beta-lactamase. From the Pasteur Institute (Genopole) list of OXY beta-lactamases. OXY-2-12 antibiotic_resistance ARO:3002407 OXY-2-12 ARO:3002407 OXY-2-12 OXY-2-13 is a beta-lactamase. From the Pasteur Institute (Genopole) list of OXY beta-lactamases. OXY-2-13 antibiotic_resistance ARO:3002408 OXY-2-13 ARO:3002408 OXY-2-13 OXY-3-1 is a beta-lactamase found in Klebsiella oxytoca. OXY-3-1 antibiotic_resistance ARO:3002409 OXY-3-1 ARO:3002409 OXY-3-1 is a beta-lactamase found in Klebsiella oxytoca. PMID:12807183 OXY-3-1 OXY-4-1 is a beta-lactamase found in Klebsiella oxytoca. OXY-4-1 antibiotic_resistance ARO:3002410 OXY-4-1 ARO:3002410 OXY-4-1 is a beta-lactamase found in Klebsiella oxytoca. PMID:12807183 OXY-4-1 OXY-5-1 is a beta-lactamase found in Klebsiella oxytoca. OXY-5-1 antibiotic_resistance ARO:3002411 OXY-5-1 ARO:3002411 OXY-5-1 is a beta-lactamase found in Klebsiella oxytoca. PMID:16048960 OXY-5-1 OXY-5-2 is a beta-lactamase found in Klebsiella oxytoca. OXY-5-2 antibiotic_resistance ARO:3002412 OXY-5-2 ARO:3002412 OXY-5-2 is a beta-lactamase found in Klebsiella oxytoca. PMID:16048960 OXY-5-2 OXY-6-1 is a beta-lactamase found in Klebsiella oxytoca. OXY-6-1 antibiotic_resistance ARO:3002413 OXY-6-1 ARO:3002413 OXY-6-1 is a beta-lactamase found in Klebsiella oxytoca. PMID:16048960 OXY-6-1 OXY-6-2 is a beta-lactamase found in Klebsiella oxytoca. OXY-6-2 antibiotic_resistance ARO:3002414 OXY-6-2 ARO:3002414 OXY-6-2 is a beta-lactamase found in Klebsiella oxytoca. PMID:16048960 OXY-6-2 OXY-6-3 is a beta-lactamase found in Klebsiella oxytoca. OXY-6-3 antibiotic_resistance ARO:3002415 OXY-6-3 ARO:3002415 OXY-6-3 is a beta-lactamase found in Klebsiella oxytoca. PMID:16048960 OXY-6-3 OXY-6-4 is a beta-lactamase found in Klebsiella oxytoca. OXY-6-4 antibiotic_resistance ARO:3002416 OXY-6-4 ARO:3002416 OXY-6-4 is a beta-lactamase found in Klebsiella oxytoca. PMID:16048960 OXY-6-4 OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. antibiotic_resistance ARO:3002417 OKP beta-lactamase ARO:3002417 OKP beta-lactamases are chromosomal class A beta-lactamase that confer resistance to penicillins and early cephalosporins in Klebsiella pneumoniae. OKP beta-lactamases can be subdivided into two groups: OKP-A and OKP-B which diverge by about 4.2%. PMID:16304190 PMID:22143810 OKP-A-1 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-1 antibiotic_resistance ARO:3002418 OKP-A-1 ARO:3002418 OKP-A-1 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-A-1 OKP-A-2 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-2 antibiotic_resistance ARO:3002419 OKP-A-2 ARO:3002419 OKP-A-2 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-A-2 OKP-A-3 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-3 antibiotic_resistance ARO:3002420 OKP-A-3 ARO:3002420 OKP-A-3 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-A-3 OKP-A-4 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-4 antibiotic_resistance ARO:3002421 OKP-A-4 ARO:3002421 OKP-A-4 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-A-4 OKP-A-5 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-5 antibiotic_resistance ARO:3002422 OKP-A-5 ARO:3002422 OKP-A-5 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-A-5 OKP-A-6 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-6 antibiotic_resistance ARO:3002423 OKP-A-6 ARO:3002423 OKP-A-6 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-A-6 OKP-A-7 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-7 antibiotic_resistance ARO:3002424 OKP-A-7 ARO:3002424 OKP-A-7 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-A-7 OKP-A-8 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-8 antibiotic_resistance ARO:3002425 OKP-A-8 ARO:3002425 OKP-A-8 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-A-8 OKP-A-9 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-9 antibiotic_resistance ARO:3002426 OKP-A-9 ARO:3002426 OKP-A-9 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-A-9 OKP-A-10 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-10 antibiotic_resistance ARO:3002427 OKP-A-10 ARO:3002427 OKP-A-10 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-A-10 OKP-A-11 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-11 antibiotic_resistance ARO:3002428 OKP-A-11 ARO:3002428 OKP-A-11 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19128913 OKP-A-11 OKP-A-12 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-12 antibiotic_resistance ARO:3002429 OKP-A-12 ARO:3002429 OKP-A-12 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19128913 OKP-A-12 OKP-A-13 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-13 antibiotic_resistance ARO:3002430 OKP-A-13 ARO:3002430 OKP-A-13 is a beta-lactamase found in Klebsiella pneumoniae. PMID:22143810 OKP-A-13 OKP-A-14 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-14 antibiotic_resistance ARO:3002431 OKP-A-14 ARO:3002431 OKP-A-14 is a beta-lactamase found in Klebsiella pneumoniae. PMID:22143810 OKP-A-14 OKP-A-15 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-15 antibiotic_resistance ARO:3002432 OKP-A-15 ARO:3002432 OKP-A-15 is a beta-lactamase found in Klebsiella pneumoniae. PMID:22143810 OKP-A-15 OKP-A-16 is a beta-lactamase found in Klebsiella pneumoniae. OKP-A-16 antibiotic_resistance ARO:3002433 OKP-A-16 ARO:3002433 OKP-A-16 is a beta-lactamase found in Klebsiella pneumoniae. PMID:22143810 OKP-A-16 OKP-B-1 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-1 antibiotic_resistance ARO:3002434 OKP-B-1 ARO:3002434 OKP-B-1 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-B-1 OKP-B-2 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-2 antibiotic_resistance ARO:3002435 OKP-B-2 ARO:3002435 OKP-B-2 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-B-2 OKP-B-3 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-3 antibiotic_resistance ARO:3002436 OKP-B-3 ARO:3002436 OKP-B-3 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-B-3 OKP-B-4 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-4 antibiotic_resistance ARO:3002437 OKP-B-4 ARO:3002437 OKP-B-4 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-B-4 OKP-B-5 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-5 antibiotic_resistance ARO:3002438 OKP-B-5 ARO:3002438 OKP-B-5 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15980410 OKP-B-5 OKP-B-6 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-15 OKP-B-6 antibiotic_resistance ARO:3002439 OKP-B-6 ARO:3002439 OKP-B-6 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15980410 OKP-B-6 OKP-B-7 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-7 antibiotic_resistance ARO:3002440 OKP-B-7 ARO:3002440 OKP-B-7 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-B-7 OKP-B-8 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-8 antibiotic_resistance ARO:3002441 OKP-B-8 ARO:3002441 OKP-B-8 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-B-8 OKP-B-9 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-9 antibiotic_resistance ARO:3002442 OKP-B-9 ARO:3002442 OKP-B-9 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-B-9 OKP-B-10 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-10 antibiotic_resistance ARO:3002443 OKP-B-10 ARO:3002443 OKP-B-10 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-B-10 OKP-B-11 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-11 antibiotic_resistance ARO:3002444 OKP-B-11 ARO:3002444 OKP-B-11 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16304190 OKP-B-11 OKP-B-12 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-12 antibiotic_resistance ARO:3002445 OKP-B-12 ARO:3002445 OKP-B-12 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15215087 OKP-B-12 OKP-B-13 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-13 antibiotic_resistance ARO:3002446 OKP-B-13 ARO:3002446 OKP-B-13 is a beta-lactamase found in Klebsiella pneumoniae. PMID:16769193 OKP-B-13 OKP-B-14 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-14 antibiotic_resistance ARO:3002447 OKP-B-14 ARO:3002447 OKP-B-14 is a beta-lactamase found in Klebsiella pneumoniae. PMID:17442542 OKP-B-14 OKP-B-17 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-17 antibiotic_resistance ARO:3002450 OKP-B-17 ARO:3002450 OKP-B-17 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19128913 OKP-B-17 OKP-B-18 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-18 antibiotic_resistance ARO:3002451 OKP-B-18 ARO:3002451 OKP-B-18 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19128913 OKP-B-18 OKP-B-19 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-19 antibiotic_resistance ARO:3002452 OKP-B-19 ARO:3002452 OKP-B-19 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19128913 OKP-B-19 OKP-B-20 is a beta-lactamase found in Klebsiella pneumoniae. OKP-B-20 antibiotic_resistance ARO:3002453 OKP-B-20 ARO:3002453 OKP-B-20 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19128913 OKP-B-20 LEN-1 is a beta-lactamase found in Klebsiella pneumoniae. LEN-1 antibiotic_resistance ARO:3002454 LEN-1 ARO:3002454 LEN-1 is a beta-lactamase found in Klebsiella pneumoniae. PMID:3533626 LEN-1 LEN-2 is a beta-lactamase found in Klebsiella pneumoniae. LEN-2 antibiotic_resistance ARO:3002455 LEN-2 ARO:3002455 LEN-2 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15215087 LEN-2 LEN-5 is a beta-lactamase found in Klebsiella pneumoniae. LEN-5 antibiotic_resistance ARO:3002456 LEN-5 ARO:3002456 LEN-5 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15215087 LEN-5 LEN-7 is a beta-lactamase found in Klebsiella pneumoniae. LEN-7 antibiotic_resistance ARO:3002457 LEN-7 ARO:3002457 LEN-7 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15215087 LEN-7 LEN-8 is a beta-lactamase found in Klebsiella pneumoniae. LEN-8 antibiotic_resistance ARO:3002458 LEN-8 ARO:3002458 LEN-8 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15215087 LEN-8 LEN-9 is a beta-lactamase found in Klebsiella pneumoniae. LEN-9 antibiotic_resistance ARO:3002459 LEN-9 ARO:3002459 LEN-9 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15215087 LEN-9 LEN-10 is a beta-lactamase found in Klebsiella pneumoniae. LEN-10 antibiotic_resistance ARO:3002460 LEN-10 ARO:3002460 LEN-10 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15215087 LEN-10 LEN-11 is a beta-lactamase found in Klebsiella pneumoniae. LEN-11 antibiotic_resistance ARO:3002461 LEN-11 ARO:3002461 LEN-11 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15215087 LEN-11 LEN-12 is a beta-lactamase found in Klebsiella pneumoniae. LEN-12 antibiotic_resistance ARO:3002462 LEN-12 ARO:3002462 LEN-12 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15215087 LEN-12 LEN-13 is a beta-lactamase found in Klebsiella pneumoniae and Klebsiella variicola. LEN-13 antibiotic_resistance ARO:3002463 LEN-13 ARO:3002463 LEN-13 is a beta-lactamase found in Klebsiella pneumoniae and Klebsiella variicola. PMID:15215087 PMID:19965433 LEN-13 LEN-16 is a beta-lactamase found in Klebsiella pneumoniae. LEN-16 antibiotic_resistance ARO:3002464 LEN-16 ARO:3002464 LEN-16 is a beta-lactamase found in Klebsiella pneumoniae. PMID:15980410 LEN-16 LEN-18 is a beta-lactamase found in Klebsiella pneumoniae. LEN-18 antibiotic_resistance ARO:3002465 LEN-18 ARO:3002465 LEN-18 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19128913 LEN-18 LEN-19 is a beta-lactamase found in Klebsiella pneumoniae. LEN-19 antibiotic_resistance ARO:3002466 LEN-19 ARO:3002466 LEN-19 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19128913 LEN-19 LEN-20 is a beta-lactamase found in Klebsiella pneumoniae. LEN-20 antibiotic_resistance ARO:3002467 LEN-20 ARO:3002467 LEN-20 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19128913 LEN-20 LEN-21 is a beta-lactamase found in Klebsiella pneumoniae. LEN-21 antibiotic_resistance ARO:3002468 LEN-21 ARO:3002468 LEN-21 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19128913 LEN-21 LEN-22 is a beta-lactamase found in Klebsiella pneumoniae. LEN-22 antibiotic_resistance ARO:3002469 LEN-22 ARO:3002469 LEN-22 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19128913 LEN-22 LEN-23 is a beta-lactamase found in Klebsiella pneumoniae. LEN-23 antibiotic_resistance ARO:3002470 LEN-23 ARO:3002470 LEN-23 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19128913 LEN-23 LEN-24 is a beta-lactamase found in Klebsiella pneumoniae. LEN-24 antibiotic_resistance ARO:3002471 LEN-24 ARO:3002471 LEN-24 is a beta-lactamase found in Klebsiella pneumoniae. PMID:19128913 LEN-24 LEN-4 is a beta-lactamase found in Escherichia coli. LEN-4 antibiotic_resistance ARO:3002472 LEN-4 ARO:3002472 LEN-4 is a beta-lactamase found in Escherichia coli. PMID:22809702 LEN-4 LEN-17 is a beta-lactamase found in Escherichia coli. LEN-17 antibiotic_resistance ARO:3002473 LEN-17 ARO:3002473 LEN-17 is a beta-lactamase found in Escherichia coli. PMID:22809702 LEN-17 LEN-26 is a beta-lactamase found in Escherichia coli and Klebsiella pneumoniae. LEN-26 antibiotic_resistance ARO:3002474 LEN-26 ARO:3002474 LEN-26 is a beta-lactamase found in Escherichia coli and Klebsiella pneumoniae. PMID:22809702 LEN-26 LEN-3 is a beta-lactamase. From the Pasteur Institute list of LEN beta-lactamases. LEN-3 antibiotic_resistance ARO:3002475 LEN-3 ARO:3002475 LEN-3 LEN-6 is a beta-lactamase. From the Pasteur Institute list of LEN beta-lactamases. LEN-6 antibiotic_resistance ARO:3002476 LEN-6 ARO:3002476 LEN-6 LEN-14 is a beta-lactamase. From the Pasteur Institute list of LEN beta-lactamases. LEN-14 antibiotic_resistance ARO:3002477 LEN-14 ARO:3002477 LEN-14 LEN-15 is a beta-lactamase. From the Pasteur Institute list of LEN beta-lactamases. LEN-15 antibiotic_resistance ARO:3002478 LEN-15 ARO:3002478 LEN-15 LEN-25 is a beta-lactamase. From the Pasteur Institute list of LEN beta-lactamases. LEN-25 antibiotic_resistance ARO:3002479 LEN-25 ARO:3002479 LEN-25 OXA-144 is a beta-lactamase found in Pseudomonas aeruginosa. OXA-144 antibiotic_resistance ARO:3002480 OXA-144 ARO:3002480 OXA-144 AER-1 is a beta-lactamase found in Aeromonas hydrophila. AER-1 antibiotic_resistance ARO:3002481 AER-1 ARO:3002481 AER-1 is a beta-lactamase found in Aeromonas hydrophila. PMID:3890725 AER-1 LRA-1 is a beta-lactamase isolated from soil samples in Alaska. LRA-1 antibiotic_resistance ARO:3002482 LRA-1 ARO:3002482 LRA-1 is a beta-lactamase isolated from soil samples in Alaska. PMID:18843302 LRA-1 LRA-5 is a beta-lactamase isolated from soil samples in Alaska. LRA-5 antibiotic_resistance ARO:3002483 LRA-5 ARO:3002483 LRA-5 is a beta-lactamase isolated from soil samples in Alaska. PMID:18843302 LRA-5 LRA-13 is a class D/class C fusion bifunctional beta-lactamase isolated from soil samples in Alaska. LRA-13 antibiotic_resistance ARO:3002484 LRA-13 ARO:3002484 LRA-13 is a class D/class C fusion bifunctional beta-lactamase isolated from soil samples in Alaska. PMID:18843302 LRA-13 LRA-2 is a beta-lactamase isolated from soil samples in Alaska. LRA-2 antibiotic_resistance ARO:3002485 LRA-2 ARO:3002485 LRA-2 is a beta-lactamase isolated from soil samples in Alaska. PMID:18843302 LRA-2 LRA-7 is a beta-lactamase isolated from soil samples in Alaska. LRA-7 antibiotic_resistance ARO:3002486 LRA-7 ARO:3002486 LRA-7 is a beta-lactamase isolated from soil samples in Alaska. PMID:18843302 LRA-7 LRA-8 is a beta-lactamase isolated from soil samples in Alaska. LRA-8 antibiotic_resistance ARO:3002487 LRA-8 ARO:3002487 LRA-8 is a beta-lactamase isolated from soil samples in Alaska. PMID:18843302 LRA-8 LRA-9 is a beta-lactamase isolated from soil samples in Alaska. LRA-9 antibiotic_resistance ARO:3002488 LRA-9 ARO:3002488 LRA-9 is a beta-lactamase isolated from soil samples in Alaska. PMID:18843302 LRA-9 LRA-10 is a beta-lactamase isolated from soil samples in Alaska. LRA-10 antibiotic_resistance ARO:3002489 LRA-10 ARO:3002489 LRA-10 is a beta-lactamase isolated from soil samples in Alaska. PMID:18843302 LRA-10 LRA-18 is a beta-lactamase isolated from soil samples in Alaska. LRA-18 antibiotic_resistance ARO:3002492 LRA-18 ARO:3002492 LRA-18 is a beta-lactamase isolated from soil samples in Alaska. PMID:18843302 LRA-18 SRT-1, isolated from Serratia marcescens, confers resistance to cephalosporins but not carbapenems, penems and monobactams. SRT-1 antibiotic_resistance ARO:3002493 SRT-1 ARO:3002493 SRT-1, isolated from Serratia marcescens, confers resistance to cephalosporins but not carbapenems, penems and monobactams. PMID:8540730 SRT-1 SRT-2, isolated from Serratia marcescens, is a chromosomal beta-lactamase that confers resistance to cefotaxime. SRT-2 antibiotic_resistance ARO:3002494 SRT-2 ARO:3002494 SRT-2, isolated from Serratia marcescens, is a chromosomal beta-lactamase that confers resistance to cefotaxime. PMID:15183862 SRT-2 CTX-M-85 is a beta-lactamase found in Salmonella enterica. CTX-M-85 antibiotic_resistance ARO:3002495 CTX-M-85 ARO:3002495 CTX-M-85 is a beta-lactamase found in Salmonella enterica. PMID:18984647 CTX-M-85 OXA-418 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-418 antibiotic_resistance ARO:3002496 OXA-418 ARO:3002496 OXA-418 PDC-1 is a beta-lactamase found in Pseudomonas aeruginosa. PDC-1 antibiotic_resistance ARO:3002497 PDC-1 ARO:3002497 PDC-1 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:19258272 PDC-1 PDC-2 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PDC-2 antibiotic_resistance ARO:3002498 PDC-2 ARO:3002498 PDC-2 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PMID:19258272 PDC-2 PDC-3 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PDC-3 antibiotic_resistance ARO:3002500 PDC-3 ARO:3002500 PDC-3 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PMID:19258272 PMID:33416461 PDC-3 PDC-4 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PDC-4 antibiotic_resistance ARO:3002501 PDC-4 ARO:3002501 PDC-4 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PMID:19258272 PDC-4 PDC-5 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PDC-5 antibiotic_resistance ARO:3002502 PDC-5 ARO:3002502 PDC-5 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PMID:19258272 PMID:33416461 PDC-5 PDC-6 is a beta-lactamase found in Pseudomonas aeruginosa. PDC-6 antibiotic_resistance ARO:3002505 PDC-6 ARO:3002505 PDC-6 is a beta-lactamase found in Pseudomonas aeruginosa. PMID:19258272 PDC-6 PDC-7 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PDC-7 antibiotic_resistance ARO:3002506 PDC-7 ARO:3002506 PDC-7 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PMID:19258272 PDC-7 PDC-8 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PDC-8 antibiotic_resistance ARO:3002507 PDC-8 ARO:3002507 PDC-8 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PMID:19258272 PDC-8 PDC-9 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PDC-9 antibiotic_resistance ARO:3002508 PDC-9 ARO:3002508 PDC-9 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PMID:19258272 PDC-9 PDC-10 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PDC-10 antibiotic_resistance ARO:3002509 PDC-10 ARO:3002509 PDC-10 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. PMID:19258272 PDC-10 LRA-3 is a beta-lactamase isolated from soil samples in Alaska. LRA-3 antibiotic_resistance ARO:3002510 LRA-3 ARO:3002510 LRA-3 is a beta-lactamase isolated from soil samples in Alaska. PMID:18843302 LRA-3 LRA-12 is a beta-lactamase isolated from soil samples in Alaska. LRA-12 antibiotic_resistance ARO:3002511 LRA-12 ARO:3002511 LRA-12 is a beta-lactamase isolated from soil samples in Alaska. PMID:18843302 LRA-12 LRA-17 is a beta-lactamase isolated from soil samples in Alaska. LRA-17 antibiotic_resistance ARO:3002512 LRA-17 ARO:3002512 LRA-17 is a beta-lactamase isolated from soil samples in Alaska. PMID:18843302 LRA-17 LRA-19 is a beta-lactamase isolated from soil samples in Alaska. LRA-19 antibiotic_resistance ARO:3002513 LRA-19 ARO:3002513 LRA-19 is a beta-lactamase isolated from soil samples in Alaska. PMID:18843302 LRA-19 OCH-1 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. OCH-1 Ochrobactrum anthropi antibiotic_resistance ARO:3002514 OCH-1 ARO:3002514 OCH-1 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. PMID:11451692 OCH-1 OCH-2 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamase in Brucella anthropi. OCH-2 antibiotic_resistance ARO:3002515 OCH-2 ARO:3002515 OCH-2 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamase in Brucella anthropi. PMID:11451692 OCH-2 OCH-3 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. OCH-3 antibiotic_resistance ARO:3002516 OCH-3 ARO:3002516 OCH-3 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. PMID:11451692 OCH-3 OCH-4 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. OCH-4 antibiotic_resistance ARO:3002517 OCH-4 ARO:3002517 OCH-4 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. PMID:11451692 OCH-4 OCH-5 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. OCH-5 antibiotic_resistance ARO:3002518 OCH-5 ARO:3002518 OCH-5 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. PMID:11451692 OCH-5 OCH-6 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. OCH-6 antibiotic_resistance ARO:3002519 OCH-6 ARO:3002519 OCH-6 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. PMID:11451692 OCH-6 OCH-7 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamase in Brucella anthropi. OCH-7 antibiotic_resistance ARO:3002520 OCH-7 ARO:3002520 OCH-7 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamase in Brucella anthropi. PMID:11451692 OCH-7 OCH-8 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. OCH-8 antibiotic_resistance ARO:3002521 OCH-8 ARO:3002521 OCH-8 beta-lactamase is an Ambler class C chromosomal-encoded beta-lactamases in Brucella anthropi. PMID:11451692 OCH-8 A type III ABC transporter, identified on the novobiocin biosynthetic gene cluster, involved in the transport and resistance of novobiocin. novA antibiotic_resistance ARO:3002522 novA ARO:3002522 A type III ABC transporter, identified on the novobiocin biosynthetic gene cluster, involved in the transport and resistance of novobiocin. PMID:12604514 novA AAC(2')-Ia is a chromosomal-encoded aminoglycoside acetyltransferase in P. stuartii. AAC(2')-Ia antibiotic_resistance ARO:3002523 AAC(2')-Ia ARO:3002523 AAC(2')-Ia is a chromosomal-encoded aminoglycoside acetyltransferase in P. stuartii. PMID:8407825 AAC(2')-Ia AAC(2')-Ib is a chromosomal-encoded aminoglycoside acetyltransferase in Mycolicibacterium fortuitum and A. baumannii. AAC(2')-Ib antibiotic_resistance ARO:3002524 AAC(2')-Ib ARO:3002524 AAC(2')-Ib is a chromosomal-encoded aminoglycoside acetyltransferase in Mycolicibacterium fortuitum and A. baumannii. PMID:8891143 AAC(2')-Ib AAC(2')-Ic is a chromosomal-encoded aminoglycoside acetyltransferase in M. tuberculosis and Mycobacterium tuberculosis variant bovis. AAC(2')-Ic antibiotic_resistance ARO:3002525 AAC(2')-Ic ARO:3002525 AAC(2')-Ic is a chromosomal-encoded aminoglycoside acetyltransferase in M. tuberculosis and Mycobacterium tuberculosis variant bovis. PMID:9159528 AAC(2')-Ic AAC(2')-Id is a chromosomal-encoded aminoglycoside acetyltransferase in Mycolicibacterium smegmatis. AAC(2')-Id antibiotic_resistance ARO:3002526 AAC(2')-Id ARO:3002526 AAC(2')-Id is a chromosomal-encoded aminoglycoside acetyltransferase in Mycolicibacterium smegmatis. PMID:9159528 AAC(2')-Id AAC(2')-Ie is a chromosomal-encoded aminoglycoside acetyltransferase in M. leprae. AAC(2')-Ie antibiotic_resistance ARO:3002527 AAC(2')-Ie ARO:3002527 AAC(2')-Ie is a chromosomal-encoded aminoglycoside acetyltransferase in M. leprae. PMID:9159528 AAC(2')-Ie AAC(3)-Ia is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in S. marcescens, E. coli, Acinetobacter baumannii, Klebsiella pneumoniae, Klebsiella oxytoca, P. aeruginosa, Salmonella typhimurium and Proteus mirabilis. AAC(3)-Ia AAC(3)-Ia C aacC-A1 aacC1 antibiotic_resistance ARO:3002528 AAC(3)-Ia ARO:3002528 AAC(3)-Ia is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in S. marcescens, E. coli, Acinetobacter baumannii, Klebsiella pneumoniae, Klebsiella oxytoca, P. aeruginosa, Salmonella typhimurium and Proteus mirabilis. PMID:1960117 PMID:2549372 AAC(3)-Ia AAC(3)-Id is an aminoglycoside acetyltransferase encoded by genomic islands and integrons in S. enterica, P. mirabilis and Vibrio fluvialis. AAC(3)-Id AAC(3)-Ie aacCA5 antibiotic_resistance ARO:3002529 AAC(3)-Id ARO:3002529 AAC(3)-Id is an aminoglycoside acetyltransferase encoded by genomic islands and integrons in S. enterica, P. mirabilis and Vibrio fluvialis. PMID:15388438 PMID:15728939 PMID:18476779 AAC(3)-Id AAC(3)-Ib is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. AAC(3)-Ib aacCA2 antibiotic_resistance ARO:3002530 AAC(3)-Ib ARO:3002530 AAC(3)-Ib is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. PMID:7486920 AAC(3)-Ib AAC(3)-Ic is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. AAC(3)-Ic aacCA3 antibiotic_resistance ARO:3002531 AAC(3)-Ic ARO:3002531 AAC(3)-Ic is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. PMID:12709352 AAC(3)-Ic AAC(3)-IIa is a plasmid-encoded aminoglycoside acetyltransferase in K. pneumoniae, E. cloacae, Actinobacillus pleuropneumoniae, S. typhimurium, Citrobacter freundii, and P. aeruginosa. AAC(3)-IIa aaC3 aac(3)-Va aacC2 aacC5 antibiotic_resistance ARO:3002533 AAC(3)-IIa ARO:3002533 AAC(3)-IIa is a plasmid-encoded aminoglycoside acetyltransferase in K. pneumoniae, E. cloacae, Actinobacillus pleuropneumoniae, S. typhimurium, Citrobacter freundii, and P. aeruginosa. PMID:3892230 PMID:8385262 PMID:8913451 AAC(3)-IIa AAC(3)-IIb is an aminoglycoside acetyltransferase in E. coli, A. faecalis and S. marcescens. AAC(3)-IIb aac(3)-Vb antibiotic_resistance ARO:3002534 AAC(3)-IIb ARO:3002534 AAC(3)-IIb is an aminoglycoside acetyltransferase in E. coli, A. faecalis and S. marcescens. PMID:1444303 PMID:8385262 AAC(3)-IIb AAC(3)-IIc is a plasmid-encoded aminoglycoside acetyltransferase in E. coli and P. aeruginosa. AAC(3)-IIc aacC2 antibiotic_resistance ARO:3002535 AAC(3)-IIc ARO:3002535 AAC(3)-IIc is a plasmid-encoded aminoglycoside acetyltransferase in E. coli and P. aeruginosa. PMID:18467306 PMID:8385262 AAC(3)-IIc AAC(3)-IIIa is a chromosomal-encoded aminoglycoside acetyltransferase in P. aeruginosa. AAC(3)-IIIa aacC3 antibiotic_resistance ARO:3002536 AAC(3)-IIIa ARO:3002536 AAC(3)-IIIa is a chromosomal-encoded aminoglycoside acetyltransferase in P. aeruginosa. PMID:1649572 AAC(3)-IIIa AAC(3)-IIIb is an aminoglycoside acetyltransferase in P. aeruginosa. AAC(3)-IIIb antibiotic_resistance ARO:3002537 AAC(3)-IIIb ARO:3002537 AAC(3)-IIIb is an aminoglycoside acetyltransferase in P. aeruginosa. PMID:20387903 AAC(3)-IIIb AAC(3)-IIIc is an aminoglycoside acetyltransferase in P. aeruginosa. AAC(3)-IIIc ANT(2'')-Ib antibiotic_resistance ARO:3002538 AAC(3)-IIIc ARO:3002538 AAC(3)-IIIc is an aminoglycoside acetyltransferase in P. aeruginosa. PMID:8385262 AAC(3)-IIIc AAC(3)-IV is a plasmid-encoded aminoglycoside acetyltransferase in E. coli, C. jejuni and P. stutzeri. AAC(3)-IVa aacC4 antibiotic_resistance ARO:3002539 AAC(3)-IVa ARO:3002539 AAC(3)-IV is a plasmid-encoded aminoglycoside acetyltransferase in E. coli, C. jejuni and P. stutzeri. PMID:19709289 PMID:6318050 AAC(3)-IVa AAC(3)-VIa is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae, S. enterica and E. coli. AAC(3)-VIa antibiotic_resistance ARO:3002540 AAC(3)-VIa ARO:3002540 AAC(3)-VIa is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae, S. enterica and E. coli. PMID:19949054 PMID:8257126 AAC(3)-VIa AAC(3)-VIIa is a chromosomal-encoded aminoglycoside acetyltransferase in Streptomyces rimosus. AAC(3)-VIIa aacC7 antibiotic_resistance ARO:3002541 AAC(3)-VIIa ARO:3002541 AAC(3)-VIIa is a chromosomal-encoded aminoglycoside acetyltransferase in Streptomyces rimosus. PMID:2914849 AAC(3)-VIIa AAC(3)-VIIIa is a chromosomal-encoded aminoglycoside acetyltransferase in Streptomyces fradiae. AAC(3)-VIIIa aacC8 antibiotic_resistance ARO:3002542 AAC(3)-VIIIa ARO:3002542 AAC(3)-VIIIa is a chromosomal-encoded aminoglycoside acetyltransferase in Streptomyces fradiae. PMID:2060791 AAC(3)-VIIIa AAC(3)-IXa is a chromosomal-encoded aminoglycoside acetyltransferase in Micromonospora chalcea. AAC(3)-IXa aacC9 antibiotic_resistance ARO:3002543 AAC(3)-IXa ARO:3002543 AAC(3)-IXa is a chromosomal-encoded aminoglycoside acetyltransferase in Micromonospora chalcea. PMID:2060791 AAC(3)-IXa AAC(3)-Xa is a chromosomal-encoded aminoglycoside acetyltransferase in Streptomyces griseus. AAC(3)-Xa antibiotic_resistance ARO:3002544 AAC(3)-Xa ARO:3002544 AAC(3)-Xa is a chromosomal-encoded aminoglycoside acetyltransferase in Streptomyces griseus. PMID:10639379 AAC(3)-Xa AAC(6')-Ia is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in Citrobacter diversus, E. coli, K. pneumoniae, Shigella sonnei, and P. aeruginosa. AAC(6')-Ia aacA1 antibiotic_resistance ARO:3002545 AAC(6')-Ia ARO:3002545 AAC(6')-Ia is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in Citrobacter diversus, E. coli, K. pneumoniae, Shigella sonnei, and P. aeruginosa. PMID:1314803 PMID:2826403 AAC(6')-Ia AAC(6')-Ib is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in K. pneumoniae, P. mirabilis, P. aeruginosa, S. enterica, K. oxytoca, S. maltophilia, E. cloacae and V. cholerae. AAC(6')-4 AAC(6')-Ib aacA4 antibiotic_resistance ARO:3002546 AAC(6')-Ib ARO:3002546 AAC(6')-Ib is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in K. pneumoniae, P. mirabilis, P. aeruginosa, S. enterica, K. oxytoca, S. maltophilia, E. cloacae and V. cholerae. PMID:16641475 PMID:2824444 PMID:2841303 AAC(6')-Ib AAC(6')-Ib-cr is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in Enterobacteriaceae. The aac(6')-Ib-cr variant gene can induce resistance against aminoglycoside and fluoroquinolone simultaneously. PDB:1V0C AAC(6')-Ib-cr1 antibiotic_resistance ARO:3002547 AAC(6')-Ib-cr1 ARO:3002547 AAC(6')-Ib-cr is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in Enterobacteriaceae. The aac(6')-Ib-cr variant gene can induce resistance against aminoglycoside and fluoroquinolone simultaneously. PMID:16369542 PMID:18710261 PMID:18812424 AAC(6')-Ib-cr1 AAC(6')-Ic is a chromosomal-encoded aminoglycoside acetyltransferase in S. marcescens. AAC(6')-III AAC(6')-Ic antibiotic_resistance ARO:3002549 AAC(6')-Ic ARO:3002549 AAC(6')-Ic is a chromosomal-encoded aminoglycoside acetyltransferase in S. marcescens. PMID:1354954 AAC(6')-Ic AAC(6')-If is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae. AAC(6')-If antibiotic_resistance ARO:3002553 AAC(6')-If ARO:3002553 AAC(6')-If is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae. PMID:7695286 AAC(6')-If AAC(6')-Ig is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter haemolyticus. AAC(6')-Ig antibiotic_resistance ARO:3002554 AAC(6')-Ig ARO:3002554 AAC(6')-Ig is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter haemolyticus. PMID:7810994 PMID:8257129 AAC(6')-Ig AAC(6')-Ih is a plasmid-encoded aminoglycoside acetyltransferase in A. baumannii. AAC(6')-Ih antibiotic_resistance ARO:3002555 AAC(6')-Ih ARO:3002555 AAC(6')-Ih is a plasmid-encoded aminoglycoside acetyltransferase in A. baumannii. PMID:7810994 AAC(6')-Ih AAC(6')-Ii is a chromosomal-encoded aminoglycoside acetyltransferase in Enterococcus spp. AAC(6')-Ii antibiotic_resistance ARO:3002556 AAC(6')-Ii ARO:3002556 AAC(6')-Ii is a chromosomal-encoded aminoglycoside acetyltransferase in Enterococcus spp. PMID:10378269 PMID:12767240 PMID:8239603 AAC(6')-Ii AAC(6')-Ij is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter genomosp. 13. AAC(6')-Ij antibiotic_resistance ARO:3002557 AAC(6')-Ij ARO:3002557 AAC(6')-Ij is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter genomosp. 13. PMID:7810994 AAC(6')-Ij AAC(6')-Ik is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter sp. AAC(6')-Ik antibiotic_resistance ARO:3002558 AAC(6')-Ik ARO:3002558 AAC(6')-Ik is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter sp. PMID:8001769 AAC(6')-Ik AAC(6')-Ip is an aminoglycoside acetyltransferase encoded by plasmids and integrons in C. freundii, E. coli, E. faecium and Klebsiella aerogenes. AAC(6')-Ip aacA16 antibiotic_resistance ARO:3002559 AAC(6')-Ip ARO:3002559 AAC(6')-Ip is an aminoglycoside acetyltransferase encoded by plasmids and integrons in C. freundii, E. coli, E. faecium and Klebsiella aerogenes. PMID:11557456 PMID:7793874 PMID:9021185 AAC(6')-Ip AAC(6')-Iq is a aminoglycoside acetyltransferase encoded by plasmids and integrons in K. pneumoniae. AAC(6')-Iq antibiotic_resistance ARO:3002560 AAC(6')-Iq ARO:3002560 AAC(6')-Iq is a aminoglycoside acetyltransferase encoded by plasmids and integrons in K. pneumoniae. PMID:9624504 AAC(6')-Iq AAC(6')-Ir is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter colistiniresistens. AAC(6')-Ir antibiotic_resistance ARO:3002561 AAC(6')-Ir ARO:3002561 AAC(6')-Ir is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter colistiniresistens. PMID:10188279 AAC(6')-Ir AAC(6')-Is is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter variabilis. AAC(6')-Is antibiotic_resistance ARO:3002562 AAC(6')-Is ARO:3002562 AAC(6')-Is is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter variabilis. PMID:10188279 AAC(6')-Is AAC(6')-Isa is a plasmid-encoded aminoglycoside acetyltransferase in Streptomyces albulus. AAC(6')-Isa antibiotic_resistance ARO:3002563 AAC(6')-Isa ARO:3002563 AAC(6')-Isa is a plasmid-encoded aminoglycoside acetyltransferase in Streptomyces albulus. PMID:15625322 AAC(6')-Isa AAC(6')-It is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter genomosp. 16. AAC(6')-It antibiotic_resistance ARO:3002564 AAC(6')-It ARO:3002564 AAC(6')-It is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter genomosp. 16. PMID:10188279 AAC(6')-It AAC(6')-Iu is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter genomosp. 17. AAC(6')-Iu antibiotic_resistance ARO:3002565 AAC(6')-Iu ARO:3002565 AAC(6')-Iu is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter genomosp. 17. PMID:10188279 AAC(6')-Iu AAC(6')-Iv is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter sp. AAC(6')-Iv antibiotic_resistance ARO:3002566 AAC(6')-Iv ARO:3002566 AAC(6')-Iv is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter sp. PMID:10188279 AAC(6')-Iv AAC(6')-Iw is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter sp. AAC(6')-Iw antibiotic_resistance ARO:3002567 AAC(6')-Iw ARO:3002567 AAC(6')-Iw is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter sp. PMID:10188279 AAC(6')-Iw AAC(6')-Ix is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter sp. AAC(6')-Ix antibiotic_resistance ARO:3002568 AAC(6')-Ix ARO:3002568 AAC(6')-Ix is a chromosomal-encoded aminoglycoside acetyltransferase in Acinetobacter sp. PMID:10188279 AAC(6')-Ix AAC(6')-Iy is a chromosomal-encoded aminoglycoside acetyltransferase in S. enteritidis and S. enterica. Regulatory mutation required to increase expression of this chromosomally-encoded gene for resistance. In the specific system, aminoglycoside resistance was due to a transcriptional fusion secondary to a chromosomal deletion in which the downstream aac(6')-Iy gene was placed under the control of the upstream nmpC promoter. AAC(6')-Iy antibiotic_resistance ARO:3002569 AAC(6')-Iy ARO:3002569 AAC(6')-Iy is a chromosomal-encoded aminoglycoside acetyltransferase in S. enteritidis and S. enterica. Regulatory mutation required to increase expression of this chromosomally-encoded gene for resistance. In the specific system, aminoglycoside resistance was due to a transcriptional fusion secondary to a chromosomal deletion in which the downstream aac(6')-Iy gene was placed under the control of the upstream nmpC promoter. PMID:10542165 AAC(6')-Iy AAC(6')-Iz is a chromosomal-encoded aminoglycoside acetyltransferase in S. maltophilia. AAC(6')-Iz antibiotic_resistance ARO:3002570 AAC(6')-Iz ARO:3002570 AAC(6')-Iz is a chromosomal-encoded aminoglycoside acetyltransferase in S. maltophilia. PMID:10508008 AAC(6')-Iz AAC(6')-Iaa is a chromosomal-encoded aminoglycoside acetyltransferase in S. typhimurium. AAC(6')-Iaa antibiotic_resistance ARO:3002571 AAC(6')-Iaa ARO:3002571 AAC(6')-Iaa is a chromosomal-encoded aminoglycoside acetyltransferase in S. typhimurium. PMID:12679553 AAC(6')-Iaa AAC(6')-Iad is a plasmid-encoded aminoglycoside acetyltransferase in Acinetobacter genomosp. 3. AAC(6')-Iad antibiotic_resistance ARO:3002572 AAC(6')-Iad ARO:3002572 AAC(6')-Iad is a plasmid-encoded aminoglycoside acetyltransferase in Acinetobacter genomosp. 3. PMID:15155202 AAC(6')-Iad AAC(6')-Iae is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa and S. enterica. AAC(6')-Iae antibiotic_resistance ARO:3002573 AAC(6')-Iae ARO:3002573 AAC(6')-Iae is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa and S. enterica. PMID:16127047 AAC(6')-Iae AAC(6')-Iaf is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa. AAC(6')-Iaf antibiotic_resistance ARO:3002574 AAC(6')-Iaf ARO:3002574 AAC(6')-Iaf is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa. PMID:19349516 AAC(6')-Iaf AAC(6')-Iai is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa. AAC(6')-Iai antibiotic_resistance ARO:3002575 AAC(6')-Iai ARO:3002575 AAC(6')-Iai is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa. PMID:26270859 AAC(6')-Iai AAC(6')-Ib3 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. AAC(6')-Ib3 AAC(6')-Ib5 aacA4 antibiotic_resistance ARO:3002576 AAC(6')-Ib3 ARO:3002576 AAC(6')-Ib3 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. PMID:1331747 PMID:9527761 AAC(6')-Ib3 AAC(6')-Ib4 is an aminoglycoside acetyltransferase in Serratia spp. AAC(6')-Ib4 antibiotic_resistance ARO:3002577 AAC(6')-Ib4 ARO:3002577 AAC(6')-Ib4 is an aminoglycoside acetyltransferase in Serratia spp. PMID:1339319 AAC(6')-Ib4 AAC(6')-Ib7 is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae and C. freundii. AAC(6')-Ib7 antibiotic_resistance ARO:3002578 AAC(6')-Ib7 ARO:3002578 AAC(6')-Ib7 is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae and C. freundii. PMID:9527761 AAC(6')-Ib7 AAC(6')-Ib8 is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae. AAC(6')-Ib8 antibiotic_resistance ARO:3002579 AAC(6')-Ib8 ARO:3002579 AAC(6')-Ib8 is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae. PMID:9527761 AAC(6')-Ib8 AAC(6')-Ib9 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. AAC(6')-Ib9 antibiotic_resistance ARO:3002580 AAC(6')-Ib9 ARO:3002580 AAC(6')-Ib9 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. PMID:9835500 AAC(6')-Ib9 AAC(6')-Ib10 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. AAC(6')-Ib10 antibiotic_resistance ARO:3002581 AAC(6')-Ib10 ARO:3002581 AAC(6')-Ib10 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. PMID:9579076 AAC(6')-Ib10 AAC(6')-Ib11 is an integron-encoded aminoglycoside acetyltransferase in S. enterica. AAC(6')-Ib11 antibiotic_resistance ARO:3002582 AAC(6')-Ib11 ARO:3002582 AAC(6')-Ib11 is an integron-encoded aminoglycoside acetyltransferase in S. enterica. PMID:12543680 AAC(6')-Ib11 AAC(6')-29a is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. AAC(6')-29a antibiotic_resistance ARO:3002583 AAC(6')-29a ARO:3002583 AAC(6')-29a is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. PMID:11158753 AAC(6')-29a AAC(6')-29b is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. AAC(6')-29b antibiotic_resistance ARO:3002584 AAC(6')-29b ARO:3002584 AAC(6')-29b is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. PMID:11158753 AAC(6')-29b AAC(6')-31 is an integron-encoded aminoglycoside acetyltransferase in Pseudomonas putida, A. baumannii and K. pneumoniae. AAC(6')-31 antibiotic_resistance ARO:3002585 AAC(6')-31 ARO:3002585 AAC(6')-31 is an integron-encoded aminoglycoside acetyltransferase in Pseudomonas putida, A. baumannii and K. pneumoniae. PMID:17470660 AAC(6')-31 AAC(6')-32 is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa. AAC(6')-32 antibiotic_resistance ARO:3002586 AAC(6')-32 ARO:3002586 AAC(6')-32 is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa. PMID:17938181 AAC(6')-32 AAC(6')-I33 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. AAC(6')-I33 antibiotic_resistance ARO:3002587 AAC(6')-I33 ARO:3002587 AAC(6')-I33 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. PMID:19738007 AAC(6')-I33 AAC(6')-I30 is an integron-encoded aminoglycoside acetyltransferase in S. enterica. AAC(6')-I30 antibiotic_resistance ARO:3002588 AAC(6')-I30 ARO:3002588 AAC(6')-I30 is an integron-encoded aminoglycoside acetyltransferase in S. enterica. PMID:15231768 AAC(6')-I30 AAC(6')-Iid is a chromosomal-encoded aminoglycoside acetyltransferase in Enterococcus durans. AAC(6')-Iid antibiotic_resistance ARO:3002589 AAC(6')-Iid ARO:3002589 AAC(6')-Iid is a chromosomal-encoded aminoglycoside acetyltransferase in Enterococcus durans. PMID:15849260 AAC(6')-Iid AAC(6')-Iih is a chromosomal-encoded aminoglycoside acetyltransferase in Enterococcus hirae. AAC(6')-Iih antibiotic_resistance ARO:3002590 AAC(6')-Iih ARO:3002590 AAC(6')-Iih is a chromosomal-encoded aminoglycoside acetyltransferase in Enterococcus hirae. PMID:15849260 AAC(6')-Iih AAC(6')-Ib-Suzhou is an aminoglycoside acetyltransferase in E. cloacae and K. pneumoniae. AAC_6_IB_Su antibiotic_resistance ARO:3002591 AAC(6')-Ib-Suzhou ARO:3002591 AAC(6')-Ib-Suzhou is an aminoglycoside acetyltransferase in E. cloacae and K. pneumoniae. PMID:18843996 AAC_6_IB_Su AAC(6')-Ib-Hangzhou is an aminoglycoside acetyltransferase in A. baumannii. AAC6_IB_HZ antibiotic_resistance ARO:3002592 AAC(6')-Ib-Hangzhou ARO:3002592 AAC(6')-Ib-Hangzhou is an aminoglycoside acetyltransferase in A. baumannii. PMID:20833577 AAC6_IB_HZ AAC(6')-Ib-SK is a chromosomal-encoded aminoglycoside acetyltransferase in Streptomyces kanamyceticus. AAC(6')-Ib-SK AAC(6')-SK kac antibiotic_resistance ARO:3002593 AAC(6')-Ib-SK ARO:3002593 AAC(6')-Ib-SK is a chromosomal-encoded aminoglycoside acetyltransferase in Streptomyces kanamyceticus. PMID:3838980 AAC(6')-Ib-SK AAC(6')-IIa is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa and S. enterica. AAC(6')-IIa antibiotic_resistance ARO:3002594 AAC(6')-IIa ARO:3002594 AAC(6')-IIa is an aminoglycoside acetyltransferase encoded by plasmids and integrons in P. aeruginosa and S. enterica. PMID:2515793 AAC(6')-IIa AAC(6')-IIb is an integron-encoded aminoglycoside acetyltransferase in P. fluorescens. AAC(6')-IIb antibiotic_resistance ARO:3002595 AAC(6')-IIb ARO:3002595 AAC(6')-IIb is an integron-encoded aminoglycoside acetyltransferase in P. fluorescens. PMID:8385262 AAC(6')-IIb AAC(6')-IIc is an aminoglycoside acetyltransferase encoded by plasmids and integrons in E. cloacae. AAC(6')-IIc antibiotic_resistance ARO:3002596 AAC(6')-IIc ARO:3002596 AAC(6')-IIc is an aminoglycoside acetyltransferase encoded by plasmids and integrons in E. cloacae. PMID:15761066 AAC(6')-IIc AAC(6')-Ie-APH(2'')-Ia is an aminoglycoside acetyltransferase encoded by plasmids and transposons in S. aureus, E. faecalis, E. faecium and Staphylococcus warneri. AAC6_Ie_APH2_Ia APH(2''), aph(2'')-bifunctional, AAC(6')-APH(2'') aac(6')-bifunctional aacA-aphD antibiotic_resistance ARO:3002597 AAC(6')-Ie-APH(2'')-Ia bifunctional protein ARO:3002597 AAC(6')-Ie-APH(2'')-Ia is an aminoglycoside acetyltransferase encoded by plasmids and transposons in S. aureus, E. faecalis, E. faecium and Staphylococcus warneri. PMID:10021417 PMID:2833561 AAC6_Ie_APH2_Ia ANT(3'')-II-AAC(6')-IId is an integron-encoded aminoglycoside acetyltransferase in S. marcescens. ANT3II_ANT6II antibiotic_resistance ARO:3002598 ANT(3'')-II-AAC(6')-IId bifunctional protein ARO:3002598 ANT(3'')-II-AAC(6')-IId is an integron-encoded aminoglycoside acetyltransferase in S. marcescens. PMID:11959575 ANT3II_ANT6II AAC(6')-30/AAC(6')-Ib' is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. AAC6_30_AAC6_Ib antibiotic_resistance ARO:3002599 AAC(6')-30/AAC(6')-Ib' bifunctional protein ARO:3002599 AAC(6')-30/AAC(6')-Ib' is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. PMID:15561846 AAC6_30_AAC6_Ib AAC(3)-Ib/AAC(6')-Ib3 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. AAC_3Ib_AAC_6Ib antibiotic_resistance ARO:3002600 AAC(3)-Ib/AAC(6')-Ib3 bifunctional protein ARO:3002600 AAC(3)-Ib/AAC(6')-Ib3 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa. PMID:11850242 AAC_3Ib_AAC_6Ib ANT(3'')-Ia is an aminoglycoside nucleotidyltransferase gene encoded by plasmids, transposons, integrons in Enterobacteriaceae, A. baumannii, P. aeruginosa and Vibrio cholerae. aadA aadA, aadA1, aad(3'')(9) aadA1-pm antibiotic_resistance ARO:3002601 aadA ARO:3002601 ANT(3'')-Ia is an aminoglycoside nucleotidyltransferase gene encoded by plasmids, transposons, integrons in Enterobacteriaceae, A. baumannii, P. aeruginosa and Vibrio cholerae. PMID:2986186 aadA aadA2 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in K. pneumoniae, Salmonella spp., Corynebacterium glutamicum, C. freundii and Aeromonas spp. aadA2 antibiotic_resistance ARO:3002602 aadA2 ARO:3002602 aadA2 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in K. pneumoniae, Salmonella spp., Corynebacterium glutamicum, C. freundii and Aeromonas spp. PMID:17526756 aadA2 aadA3 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids, transposons and integrons in E. coli. aadA3 antibiotic_resistance ARO:3002603 aadA3 ARO:3002603 aadA3 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids, transposons and integrons in E. coli. PMID:1314803 aadA3 aadA4 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and chromosomes in Bordetella parapertussis and E. coli. aadA4 antibiotic_resistance ARO:3002604 aadA4 ARO:3002604 aadA4 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and chromosomes in Bordetella parapertussis and E. coli. PMID:12910271 PMID:18458128 aadA4 aadA5 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids, transposons and integrons in E. coli, K. pneumoniae, Kluyvera georgiana, P. aeruginosa and E. cloacae. aadA5 antibiotic_resistance ARO:3002605 aadA5 ARO:3002605 aadA5 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids, transposons and integrons in E. coli, K. pneumoniae, Kluyvera georgiana, P. aeruginosa and E. cloacae. PMID:10582907 aadA5 aadA6 is an integron-encoded aminoglycoside nucleotidyltransferase gene in P. aeruginosa. aadA6 antibiotic_resistance ARO:3002606 aadA6 ARO:3002606 aadA6 is an integron-encoded aminoglycoside nucleotidyltransferase gene in P. aeruginosa. PMID:10673049 aadA6 aadA7 is an integron-encoded aminoglycoside nucleotidyltransferase gene in V. fluvialis, P. aeruginosa, E. coli, V. cholerae and S. enterica. aadA7 antibiotic_resistance ARO:3002607 aadA7 ARO:3002607 aadA7 is an integron-encoded aminoglycoside nucleotidyltransferase gene in V. fluvialis, P. aeruginosa, E. coli, V. cholerae and S. enterica. PMID:15117923 aadA7 aadA8 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in V. cholerae, K. pneumoniae and Bacillus endophyticus. aadA8 antibiotic_resistance ARO:3002608 aadA8 ARO:3002608 aadA8 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in V. cholerae, K. pneumoniae and Bacillus endophyticus. PMID:19719593 aadA8 aadA9 is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in C. glutamicum. aadA9 antibiotic_resistance ARO:3002609 aadA9 ARO:3002609 aadA9 is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in C. glutamicum. PMID:12383729 aadA9 aadA11 is an integron-encoded aminoglycoside nucleotidyltransferase gene in E. coli and P. aeruginosa. aadA11 antibiotic_resistance ARO:3002611 aadA11 ARO:3002611 aadA11 is an integron-encoded aminoglycoside nucleotidyltransferase gene in E. coli and P. aeruginosa. PMID:16451415 aadA11 aadA12 is an integron-encoded aminoglycoside nucleotidyltransferase gene in E. coli, Yersinia enterocolitica and S. enterica. aadA12 antibiotic_resistance ARO:3002612 aadA12 ARO:3002612 aadA12 is an integron-encoded aminoglycoside nucleotidyltransferase gene in E. coli, Yersinia enterocolitica and S. enterica. PMID:19538087 aadA12 aadA13 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in Pseudomonas rettgeri, P. aeruginosa, Y. enterocolitica and E. coli. aadA13 antibiotic_resistance ARO:3002613 aadA13 ARO:3002613 aadA13 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in Pseudomonas rettgeri, P. aeruginosa, Y. enterocolitica and E. coli. PMID:18268088 aadA13 aadA14 is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in Pasteurella multocida. aadA14 antibiotic_resistance ARO:3002614 aadA14 ARO:3002614 aadA14 is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in Pasteurella multocida. PMID:15980396 aadA14 aadA15 is an integron-encoded aminoglycoside nucleotidyltransferase gene in P. aeruginosa. aadA15 antibiotic_resistance ARO:3002615 aadA15 ARO:3002615 aadA15 is an integron-encoded aminoglycoside nucleotidyltransferase gene in P. aeruginosa. PMID:16816399 aadA15 aadA16 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in E. coli, V. cholerae and K. pneumoniae. aadA16 antibiotic_resistance ARO:3002616 aadA16 ARO:3002616 aadA16 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in E. coli, V. cholerae and K. pneumoniae. PMID:19008256 aadA16 aadA17 is an integron-encoded aminoglycoside nucleotidyltransferase gene in Aeromonas media. aadA17 antibiotic_resistance ARO:3002617 aadA17 ARO:3002617 aadA17 is an integron-encoded aminoglycoside nucleotidyltransferase gene in Aeromonas media. PMID:22127350 aadA17 aadA21 is an integron-encoded aminoglycoside nucleotidyltransferase gene in Salmonella spp. aadA21 antibiotic_resistance ARO:3002618 aadA21 ARO:3002618 aadA21 is an integron-encoded aminoglycoside nucleotidyltransferase gene in Salmonella spp. PMID:12760885 aadA21 aadA22 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in S. enterica and E. coli. aadA22 antibiotic_resistance ARO:3002619 aadA22 ARO:3002619 aadA22 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in S. enterica and E. coli. PMID:17597002 aadA22 aadA23 is an integron-encoded aminoglycoside nucleotidyltransferase gene in S. enterica. aadA23 antibiotic_resistance ARO:3002620 aadA23 ARO:3002620 aadA23 is an integron-encoded aminoglycoside nucleotidyltransferase gene in S. enterica. PMID:15761062 aadA23 aadA24 is an integron-encoded aminoglycoside nucleotidyltransferase gene in Salmonella spp. aadA24 antibiotic_resistance ARO:3002621 aadA24 ARO:3002621 aadA24 is an integron-encoded aminoglycoside nucleotidyltransferase gene in Salmonella spp. PMID:17650961 aadA24 aadA6/aadA10 is an integron-encoded aminoglycoside nucleotidyltransferase gene cassette in P. aeruginosa. aadA6/aadA10 antibiotic_resistance ARO:3002622 aadA6/aadA10 ARO:3002622 aadA6/aadA10 is an integron-encoded aminoglycoside nucleotidyltransferase gene cassette in P. aeruginosa. PMID:16495246 aadA6/aadA10 ANT(4')-Ia is a plasmid-encoded aminoglycoside nucleotidyltransferase in S. epidermidis, S. aureus, Enterococcus spp. and Bacillus spp. ANT(4')-Ia aadD1 antibiotic_resistance ARO:3002623 ANT(4')-Ia ARO:3002623 ANT(4')-Ia is a plasmid-encoded aminoglycoside nucleotidyltransferase in S. epidermidis, S. aureus, Enterococcus spp. and Bacillus spp. PMID:3010356 PMID:659332 ANT(4')-Ia ANT(4')-IIa is a plasmid-encoded aminoglycoside nucleotidyltransferase in P. aeruginosa and Enterobacteriaceae. ANT(4')-IIa antibiotic_resistance ARO:3002624 ANT(4')-IIa ARO:3002624 ANT(4')-IIa is a plasmid-encoded aminoglycoside nucleotidyltransferase in P. aeruginosa and Enterobacteriaceae. PMID:1965106 PMID:8494365 ANT(4')-IIa ANT(4')-IIb is a transposon-encoded aminoglycoside nucleotidyltransferase in P. aeruginosa. ANT(4')-IIb antibiotic_resistance ARO:3002625 ANT(4')-IIb ARO:3002625 ANT(4')-IIb is a transposon-encoded aminoglycoside nucleotidyltransferase in P. aeruginosa. PMID:12709326 ANT(4')-IIb ANT(6)-Ia is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and chromosomes in Staphylococcus epidermidis, E. faecium, Streptococcus suis, S. aureus, E. faecalis and Streptococcus mitis. ANT(6)-Ia ant6, aadE antibiotic_resistance ARO:3002626 ANT(6)-Ia ARO:3002626 ANT(6)-Ia is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and chromosomes in Staphylococcus epidermidis, E. faecium, Streptococcus suis, S. aureus, E. faecalis and Streptococcus mitis. PMID:15774886 PMID:19603075 PMID:2168151 ANT(6)-Ia aadK is a chromosomal-encoded aminoglycoside nucleotidyltransferase gene in B. subtilis and Bacillus spp. This enzyme confers low-level resistance to streptomycin. aadK antibiotic_resistance ARO:3002627 aadK ARO:3002627 aadK is a chromosomal-encoded aminoglycoside nucleotidyltransferase gene in B. subtilis and Bacillus spp. This enzyme confers low-level resistance to streptomycin. PMID:2550327 PMID:8293959 aadK ANT(6)-Ia/aad(6) is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in E. faecalis and Streptococcus oralis. aac(6) aad(6) antibiotic_resistance ARO:3002628 aad(6) ARO:3002628 ANT(6)-Ia/aad(6) is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in E. faecalis and Streptococcus oralis. PMID:11735367 PMID:17407061 aad(6) ANT(6)-Ib is an aminoglycoside nucleotidyltransferase gene encoded by transferable pathogenicity islands in C. fetus subsp. fetus and B. subtilis. ANT(6)-Ib antibiotic_resistance ARO:3002629 ANT(6)-Ib ARO:3002629 ANT(6)-Ib is an aminoglycoside nucleotidyltransferase gene encoded by transferable pathogenicity islands in C. fetus subsp. fetus and B. subtilis. PMID:20479200 ANT(6)-Ib ANT(9)-Ia is an aminoglycoside nucleotidyltransferase encoded by plasmids and transposons in S. aureus, Enterococcus spp., Mammaliicoccus sciuri, and E. faecalis. ANT(9)-Ia aad(9) aad9 spc spw antibiotic_resistance ARO:3002630 ANT(9)-Ia ARO:3002630 ANT(9)-Ia is an aminoglycoside nucleotidyltransferase encoded by plasmids and transposons in S. aureus, Enterococcus spp., Mammaliicoccus sciuri, and E. faecalis. PMID:23511231 PMID:2993813 PMID:3004956 ANT(9)-Ia spd is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in S. aureus. spd antibiotic_resistance ARO:3002631 spd ARO:3002631 spd is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in S. aureus. PMID:24402501 spd APH(2'')-Ie is a plasmid or transposon-encoded aminoglycoside phosphotransferase in E. faecium and E. casseliflavus. APH(2'')-Ie antibiotic_resistance ARO:3002634 APH(2'')-Ie ARO:3002634 APH(2'')-Ie is a plasmid or transposon-encoded aminoglycoside phosphotransferase in E. faecium and E. casseliflavus. PMID:17030911 APH(2'')-Ie APH(2'')-IIa is a chromosomal-encoded aminoglycoside phosphotransferase in E. faecium and E. coli. PDB:3HAV APH(2'')-IIa aph(2'')-Ib antibiotic_resistance ARO:3002635 APH(2'')-IIa ARO:3002635 APH(2'')-IIa is a chromosomal-encoded aminoglycoside phosphotransferase in E. faecium and E. coli. PMID:10991878 APH(2'')-IIa APH(2'')-IIIa is a plasmid-encoded aminoglycoside phosphotransferase in Enterococcus gallinarum. APH(2'')-IIIa aph(2'')-Ic antibiotic_resistance ARO:3002636 APH(2'')-IIIa ARO:3002636 APH(2'')-IIIa is a plasmid-encoded aminoglycoside phosphotransferase in Enterococcus gallinarum. PMID:9055984 APH(2'')-IIIa APH(2'')-IVa is a chromosomal-encoded aminoglycoside phosphotransferase in E. casseliflavus. PDB:3N4T APH(2'')-IVa aph(2'')-Id antibiotic_resistance ARO:3002637 APH(2'')-IVa ARO:3002637 APH(2'')-IVa is a chromosomal-encoded aminoglycoside phosphotransferase in E. casseliflavus. PMID:9593155 APH(2'')-IVa APH(3'')-Ia is a chromosomal-encoded aminoglycoside phosphotransferase in S. griseus. APH(3'')-Ia aphD2 aphE antibiotic_resistance ARO:3002638 APH(3'')-Ia ARO:3002638 APH(3'')-Ia is a chromosomal-encoded aminoglycoside phosphotransferase in S. griseus. PMID:2167474 APH(3'')-Ia APH(3'')-Ib is an aminoglycoside phosphotransferase encoded by plasmids, transposons, integrative conjugative elements and chromosomes in Enterobacteriaceae and Pseudomonas spp. APH(3'')-Ib orfH strA antibiotic_resistance ARO:3002639 APH(3'')-Ib ARO:3002639 APH(3'')-Ib is an aminoglycoside phosphotransferase encoded by plasmids, transposons, integrative conjugative elements and chromosomes in Enterobacteriaceae and Pseudomonas spp. PMID:2653965 APH(3'')-Ib APH(3'')-Ic is a chromosomal-encoded aminoglycoside phosphotransferase in Mycolicibacterium fortuitum. APH(3'')-Ic antibiotic_resistance ARO:3002640 APH(3'')-Ic ARO:3002640 APH(3'')-Ic is a chromosomal-encoded aminoglycoside phosphotransferase in Mycolicibacterium fortuitum. PMID:16954315 APH(3'')-Ic APH(3')-Ia is a transposon-encoded aminoglycoside phosphotransferase in E. coli and S. enterica. It is identical at the protein sequence to APH(3')-Ic, an aminoglycoside phosphotransferase encoded by plasmids, transposons and genomic islands in K. pneumoniae, A. baumannii, S. marcescens, Corynebacterium spp., Photobacterium spp. and Citrobacter spp. APH(3')-Ia APH(3')-Ic aphA-1 apha1-1AB apha7 antibiotic_resistance ARO:3002641 APH(3')-Ia ARO:3002641 APH(3')-Ia is a transposon-encoded aminoglycoside phosphotransferase in E. coli and S. enterica. It is identical at the protein sequence to APH(3')-Ic, an aminoglycoside phosphotransferase encoded by plasmids, transposons and genomic islands in K. pneumoniae, A. baumannii, S. marcescens, Corynebacterium spp., Photobacterium spp. and Citrobacter spp. PMID:10732668 PMID:2160941 PMID:6270337 APH(3')-Ia APH(3')-Ib is a plasmid-encoded aminoglycoside phosphotransferase in E. coli. APH(3')-Ib aphA-like antibiotic_resistance ARO:3002642 APH(3')-Ib ARO:3002642 APH(3')-Ib is a plasmid-encoded aminoglycoside phosphotransferase in E. coli. PMID:2832861 APH(3')-Ib APH(3')-IIa is a transposon-encoded aminoglycoside phosphotransferase in E. coli. PDB:1ND4 APH(3')-IIa aphA-2 antibiotic_resistance ARO:3002644 APH(3')-IIa ARO:3002644 APH(3')-IIa is a transposon-encoded aminoglycoside phosphotransferase in E. coli. PMID:6295884 APH(3')-IIa APH(3')-IIb is a chromosomal-encoded aminoglycoside phosphotransferase in P. aeruginosa. APH(3')-IIb APH(3')-IIps antibiotic_resistance ARO:3002645 APH(3')-IIb ARO:3002645 APH(3')-IIb is a chromosomal-encoded aminoglycoside phosphotransferase in P. aeruginosa. PMID:10984043 PMID:14638496 APH(3')-IIb APH(3')-IIc is a chromosomal-encoded aminoglycoside phosphotransferase in S. maltophilia. APH(3')-IIc antibiotic_resistance ARO:3002646 APH(3')-IIc ARO:3002646 APH(3')-IIc is a chromosomal-encoded aminoglycoside phosphotransferase in S. maltophilia. PMID:17088477 APH(3')-IIc APH(3')-IIIa is a plasmid-encoded aminoglycoside phosphotransferase in S. aureus and Enterococcus spp. PDB:1L8T APH(3')-IIIa antibiotic_resistance ARO:3002647 APH(3')-IIIa ARO:3002647 APH(3')-IIIa is a plasmid-encoded aminoglycoside phosphotransferase in S. aureus and Enterococcus spp. PMID:6313476 APH(3')-IIIa APH(3')-IVa is a chromosomal-encoded aminoglycoside phosphotransferase in Niallia circulans. APH(3')-IVa aphA-4 antibiotic_resistance ARO:3002648 APH(3')-IVa ARO:3002648 APH(3')-IVa is a chromosomal-encoded aminoglycoside phosphotransferase in Niallia circulans. PMID:3006668 APH(3')-IVa APH(3')-Va is a chromosomal-encoded aminoglycoside phosphotransferase in Streptomyces fradiae. APH(3')-Va aphA-5a antibiotic_resistance ARO:3002649 APH(3')-Va ARO:3002649 APH(3')-Va is a chromosomal-encoded aminoglycoside phosphotransferase in Streptomyces fradiae. PMID:6310563 APH(3')-Va APH(3')-Vb is a chromosomal-encoded aminoglycoside phosphotransferase in Streptomyces ribosidificus. APH(3')-Vb aphA-5b, rph antibiotic_resistance ARO:3002650 APH(3')-Vb ARO:3002650 APH(3')-Vb is a chromosomal-encoded aminoglycoside phosphotransferase in Streptomyces ribosidificus. PMID:2851496 APH(3')-Vb APH(3')-Vc is a chromosomal-encoded aminoglycoside phosphotransferase in M. chalcea. APH(3')-Vc aphA-5c antibiotic_resistance ARO:3002651 APH(3')-Vc ARO:3002651 APH(3')-Vc is a chromosomal-encoded aminoglycoside phosphotransferase in M. chalcea. PMID:1663923 APH(3')-Vc APH(3')-VIa is a plasmid-encoded aminoglycoside phosphotransferase in A. baumannii. APH(3')-VIa aphA-6 antibiotic_resistance ARO:3002652 APH(3')-VIa ARO:3002652 APH(3')-VIa is a plasmid-encoded aminoglycoside phosphotransferase in A. baumannii. PMID:2846986 APH(3')-VIa APH(3')-VIb is a plasmid-encoded aminoglycoside phosphotransferase in K. pneumoniae and S. marcescens. APH(3')-VIb antibiotic_resistance ARO:3002653 APH(3')-VIb ARO:3002653 APH(3')-VIb is a plasmid-encoded aminoglycoside phosphotransferase in K. pneumoniae and S. marcescens. PMID:2848443 APH(3')-VIb APH(3')-VIIa is a plasmid-encoded aminoglycoside phosphotransferase in C. jejuni. APH(3')-VIIa aphA-7 antibiotic_resistance ARO:3002654 APH(3')-VIIa ARO:3002654 APH(3')-VIIa is a plasmid-encoded aminoglycoside phosphotransferase in C. jejuni. PMID:2550983 APH(3')-VIIa APH(4)-Ia is a plasmid-encoded aminoglycoside phosphotransferase in E. coli. PDB:3OVC APH(4)-Ia hph antibiotic_resistance ARO:3002655 APH(4)-Ia ARO:3002655 APH(4)-Ia is a plasmid-encoded aminoglycoside phosphotransferase in E. coli. PMID:6314265 APH(4)-Ia APH(4)-Ib is a chromosomal-encoded aminoglycoside phosphotransferase in Pseudomonas pseudomallei. APH(4)-Ib hyg antibiotic_resistance ARO:3002656 APH(4)-Ib ARO:3002656 APH(4)-Ib is a chromosomal-encoded aminoglycoside phosphotransferase in Pseudomonas pseudomallei. PMID:3005976 APH(4)-Ib APH(6)-Ia is a chromosomal-encoded aminoglycoside phosphotransferase in S. griseus. APH(6)-Ia aphD antibiotic_resistance ARO:3002657 APH(6)-Ia ARO:3002657 APH(6)-Ia is a chromosomal-encoded aminoglycoside phosphotransferase in S. griseus. PMID:3118332 APH(6)-Ia APH(6)-Ib is a chromosomal-encoded aminoglycoside phosphotransferase in S. glaucescens. APH(6)-Ib sph antibiotic_resistance ARO:3002658 APH(6)-Ib ARO:3002658 APH(6)-Ib is a chromosomal-encoded aminoglycoside phosphotransferase in S. glaucescens. PMID:3039305 APH(6)-Ib APH(6)-Ic is a transposon-encoded aminoglycoside phosphotransferase in S. enterica, P. aeruginosa and E. coli. APH(6)-Ic sph str antibiotic_resistance ARO:3002659 APH(6)-Ic ARO:3002659 APH(6)-Ic is a transposon-encoded aminoglycoside phosphotransferase in S. enterica, P. aeruginosa and E. coli. PMID:15102449 PMID:3889831 APH(6)-Ic APH(6)-Id is an aminoglycoside phosphotransferase encoded by plasmids, integrative conjugative elements and chromosomal genomic islands in K. pneumoniae, Salmonella spp., E. coli, Shigella flexneri, Providencia alcalifaciens, Pseudomonas spp., V. cholerae, Edwardsiella tarda, Pasteurella multocida and Aeromonas bestiarum. APH(6)-Id strB, orfI antibiotic_resistance ARO:3002660 APH(6)-Id ARO:3002660 APH(6)-Id is an aminoglycoside phosphotransferase encoded by plasmids, integrative conjugative elements and chromosomal genomic islands in K. pneumoniae, Salmonella spp., E. coli, Shigella flexneri, Providencia alcalifaciens, Pseudomonas spp., V. cholerae, Edwardsiella tarda, Pasteurella multocida and Aeromonas bestiarum. PMID:15722395 PMID:18413319 PMID:19465049 PMID:2653965 APH(6)-Id APH(7'')-Ia is a chromosomal-encoded aminoglycoside phosphotransferase in S. hygroscopicus. APH(7'')-Ia antibiotic_resistance ARO:3002661 APH(7'')-Ia ARO:3002661 APH(7'')-Ia is a chromosomal-encoded aminoglycoside phosphotransferase in S. hygroscopicus. PMID:12627869 APH(7'')-Ia APH(9)-Ia is a chromosomal-encoded aminoglycoside phosphotransferase in L. pneumophila. PDB:3I0O APH(9)-Ia antibiotic_resistance ARO:3002662 APH(9)-Ia ARO:3002662 APH(9)-Ia is a chromosomal-encoded aminoglycoside phosphotransferase in L. pneumophila. PMID:9174205 APH(9)-Ia APH(9)-Ib is a chromosomal-encoded aminoglycoside phosphotransferase in S. flavopersicus. APH(9)-Ib spcN antibiotic_resistance ARO:3002663 APH(9)-Ib ARO:3002663 APH(9)-Ib is a chromosomal-encoded aminoglycoside phosphotransferase in S. flavopersicus. PMID:9245803 APH(9)-Ib NpmA is a plasmid-mediated aminoglycoside-resistance 16S rRNA methyltransferase by interfering with aminoglycoside binding with the A site of 16S rRNA through N-1 methylation at position A1408. npmA antibiotic_resistance ARO:3002665 npmA ARO:3002665 NpmA is a plasmid-mediated aminoglycoside-resistance 16S rRNA methyltransferase by interfering with aminoglycoside binding with the A site of 16S rRNA through N-1 methylation at position A1408. PMID:17875999 npmA RmtF is a 16S rRNA methyltransferase found in Pseudomonas aeruginosa which methylates G1405 of the 16S rRNA. It confers high level resistance to many aminoglycosides. rmtF antibiotic_resistance ARO:3002666 rmtF ARO:3002666 RmtF is a 16S rRNA methyltransferase found in Pseudomonas aeruginosa which methylates G1405 of the 16S rRNA. It confers high level resistance to many aminoglycosides. PMID:22547620 PMID:26488937 rmtF RmtD is a 16S rRNA methyltransferase found in Pseudomonas aeruginosa which methylates G1405 of the 16S rRNA. It confers high level resistance to many aminoglycosides. rmtD antibiotic_resistance ARO:3002667 rmtD ARO:3002667 RmtD is a 16S rRNA methyltransferase found in Pseudomonas aeruginosa which methylates G1405 of the 16S rRNA. It confers high level resistance to many aminoglycosides. PMID:17158944 PMID:18222955 rmtD RmtG is a 16S rRNA methyltransferase found in Pseudomonas aeruginosa which methylates G1405 of the 16S rRNA. It confers high level resistance to many aminoglycosides. rmtG antibiotic_resistance ARO:3002668 rmtG ARO:3002668 RmtG is a 16S rRNA methyltransferase found in Pseudomonas aeruginosa which methylates G1405 of the 16S rRNA. It confers high level resistance to many aminoglycosides. PMID:23459483 rmtG APH('')-Ig is a plasmid-encoded aminoglycoside phosphotransferase in Campylobacter coli. APH(2'')-Ig antibiotic_resistance ARO:3002669 APH(2'')-Ig ARO:3002669 APH('')-Ig is a plasmid-encoded aminoglycoside phosphotransferase in Campylobacter coli. PMID:23959310 APH(2'')-Ig cat is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. cat antibiotic_resistance ARO:3002670 cat ARO:3002670 cat is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Alkalihalobacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini. PMID:11553538 PMID:11677608 PMID:11735367 PMID:11743194 PMID:12603745 PMID:12726767 PMID:12732947 PMID:1406372 PMID:1461942 PMID:1517170 PMID:1650008 PMID:1713259 PMID:1929282 PMID:1929326 PMID:19459958 PMID:2013403 PMID:2227449 PMID:2697637 PMID:2993795 PMID:3110008 PMID:3860383 PMID:3865770 PMID:3900035 PMID:6950931 PMID:9349809 cat cat-TC is a plasmid-encoded variant of the cat gene found in Limosilactobacillus reuteri. Lreu_cat-TC antibiotic_resistance ARO:3002671 Limosilactobacillus reuteri cat-TC ARO:3002671 cat-TC is a plasmid-encoded variant of the cat gene found in Limosilactobacillus reuteri. PMID:8954883 Lreu_cat-TC cat86 is a chromosome-encoded variant of the cat gene found in Bacillus pumilus. Bpum_cat86 antibiotic_resistance ARO:3002672 Bacillus pumilus cat86 ARO:3002672 cat86 is a chromosome-encoded variant of the cat gene found in Bacillus pumilus. PMID:6315534 Bpum_cat86 catB is a chromosome-encoded variant of the cat gene found in Clostridium butyricum. Cbut_catB antibiotic_resistance ARO:3002674 Clostridium butyricum catB ARO:3002674 catB is a chromosome-encoded variant of the cat gene found in Clostridium butyricum. PMID:1489203 Cbut_catB catB2 is a plasmid-encoded variant of the cat gene found in Escherichia coli, Salmonella enteritidis and Pasteurella multocida. catB2 antibiotic_resistance ARO:3002675 catB2 ARO:3002675 catB2 is a plasmid-encoded variant of the cat gene found in Escherichia coli, Salmonella enteritidis and Pasteurella multocida. PMID:12089302 PMID:1314803 PMID:19719593 catB2 catB3 is a plasmid or chromosome-encoded variant of the cat gene found in Salmonella typhimurium, Acinetobacter baumannii and Escherichia coli. catB3 catB4 antibiotic_resistance ARO:3002676 catB3 ARO:3002676 catB3 is a plasmid or chromosome-encoded variant of the cat gene found in Salmonella typhimurium, Acinetobacter baumannii and Escherichia coli. PMID:12654674 PMID:12821475 PMID:7793874 PMID:9835490 catB3 catB6 is a plasmid-encoded variant of the cat gene found in Pseudomonas aeruginosa. Paer_catB6 antibiotic_resistance ARO:3002678 Pseudomonas aeruginosa catB6 ARO:3002678 catB6 is a plasmid-encoded variant of the cat gene found in Pseudomonas aeruginosa. PMID:10103196 Paer_catB6 catB7 is a chromosome-encoded variant of the cat gene found in Pseudomonas aeruginosa. Paer_catB7 antibiotic_resistance ARO:3002679 Pseudomonas aeruginosa catB7 ARO:3002679 catB7 is a chromosome-encoded variant of the cat gene found in Pseudomonas aeruginosa. PMID:10361706 PMID:10984043 Paer_catB7 catB8 is a plasmid or integron-encoded variant of the cat gene found in Klebsiella pneumoniae, Salmonella typhi and Pseudomonas aeruginosa. catB8 antibiotic_resistance ARO:3002680 catB8 ARO:3002680 catB8 is a plasmid or integron-encoded variant of the cat gene found in Klebsiella pneumoniae, Salmonella typhi and Pseudomonas aeruginosa. PMID:12760886 catB8 catB9 is a chromosome-encoded variant of the cat gene found in Vibrio cholerae. catB9 antibiotic_resistance ARO:3002681 catB9 ARO:3002681 catB9 is a chromosome-encoded variant of the cat gene found in Vibrio cholerae. PMID:10952301 PMID:11952913 catB9 catD is a chromosome and transposon-encoded variant of the cat gene found in Clostridioides difficile. catD antibiotic_resistance ARO:3002682 catD ARO:3002682 catD is a chromosome and transposon-encoded variant of the cat gene found in Clostridioides difficile. PMID:11069682 catD catA1 (formerly in CARD as catI) is a chromosome and transposon-encoded variant of the cat gene found in Escherichia coli and Acinetobacter baumannii. cat1 catA1 catI antibiotic_resistance ARO:3002683 catA1 ARO:3002683 catA1 (formerly in CARD as catI) is a chromosome and transposon-encoded variant of the cat gene found in Escherichia coli and Acinetobacter baumannii. PMID:1650008 PMID:390403 catA1 catII is a plasmid-encoded variant of the cat gene found in Haemophilus influenzae, Agrobacterium tumefaciens and Escherichia coli. catII antibiotic_resistance ARO:3002684 catII ARO:3002684 catII is a plasmid-encoded variant of the cat gene found in Haemophilus influenzae, Agrobacterium tumefaciens and Escherichia coli. PMID:2268278 catII catIII is a plasmid-encoded variant of the cat gene found in Shigella flexneri. catA3 catIII antibiotic_resistance ARO:3002685 catIII ARO:3002685 catIII is a plasmid-encoded variant of the cat gene found in Shigella flexneri. PMID:3048245 catIII catP is a transposon and chromosome-encoded variant of the cat gene found in Clostridium perfringens and Neisseria meningitidis. catP antibiotic_resistance ARO:3002686 catP ARO:3002686 catP is a transposon and chromosome-encoded variant of the cat gene found in Clostridium perfringens and Neisseria meningitidis. PMID:7565113 PMID:9744970 catP catQ is a chromosome-encoded variant of the cat gene found in Clostridium perfringens. catQ antibiotic_resistance ARO:3002687 catQ ARO:3002687 catQ is a chromosome-encoded variant of the cat gene found in Clostridium perfringens. PMID:2039197 catQ catS is a chromosome-encoded variant of the cat gene found in Streptococcus pyogenes. catS antibiotic_resistance ARO:3002688 catS ARO:3002688 catS is a chromosome-encoded variant of the cat gene found in Streptococcus pyogenes. PMID:8109922 catS Plasmid-encoded cat, or pp-cat, is a plasmid-encoded variant of the cat gene found in Photobacterium damselae subsp. piscicida. pp_cat antibiotic_resistance ARO:3002689 Plasmid-encoded cat (pp-cat) ARO:3002689 Plasmid-encoded cat, or pp-cat, is a plasmid-encoded variant of the cat gene found in Photobacterium damselae subsp. piscicida. PMID:8271973 pp_cat cmlR is a plasmid or chromosome-encoded chloramphenicol resistance determinant (putative transmembrane protein) that is found in Escherichia coli and Streptomyces lividans. Sliv_cmlR antibiotic_resistance ARO:3002690 Streptomyces lividans cmlR ARO:3002690 cmlR is a plasmid or chromosome-encoded chloramphenicol resistance determinant (putative transmembrane protein) that is found in Escherichia coli and Streptomyces lividans. PMID:1779766 PMID:3011609 Sliv_cmlR cmlA is a plasmid-encoded chloramphenicol exporter that is found in Salmonella typhimurium. Sent_cmlA antibiotic_resistance ARO:3002691 Salmonella enterica cmlA ARO:3002691 cmlA is a plasmid-encoded chloramphenicol exporter that is found in Salmonella typhimurium. PMID:11959555 Sent_cmlA cmlA1 is a plasmid or transposon-encoded chloramphenicol exporter that is found in Pseudomonas aeruginosa and Klebsiella pneumoniae. cmlA1 antibiotic_resistance ARO:3002693 cmlA1 ARO:3002693 cmlA1 is a plasmid or transposon-encoded chloramphenicol exporter that is found in Pseudomonas aeruginosa and Klebsiella pneumoniae. PMID:11600350 PMID:12936998 PMID:1648560 PMID:1658833 cmlA1 cmlA4 is a plasmid-encoded chloramphenicol exporter that is found in Klebsiella pneumoniae. cmlA4 antibiotic_resistance ARO:3002694 cmlA4 ARO:3002694 cmlA4 is a plasmid-encoded chloramphenicol exporter that is found in Klebsiella pneumoniae. PMID:10681329 cmlA4 cmlA5 is a plasmid or transposon-encoded chloramphenicol exporter that is found in Escherichia coli. cmlA5 cmlA7 antibiotic_resistance ARO:3002695 cmlA5 ARO:3002695 cmlA5 is a plasmid or transposon-encoded chloramphenicol exporter that is found in Escherichia coli. PMID:10049269 PMID:19719593 cmlA5 cmlA6 is a plasmid-encoded chloramphenicol exporter that is found in Pseudomonas aeruginosa. cmlA6 antibiotic_resistance ARO:3002696 cmlA6 ARO:3002696 cmlA6 is a plasmid-encoded chloramphenicol exporter that is found in Pseudomonas aeruginosa. PMID:11353602 cmlA6 cmlB is a plasmid-encoded chloramphenicol exporter that is found in Klebsiella aerogenes. cmlA2 cmlB antibiotic_resistance ARO:3002698 cmlB ARO:3002698 cmlB is a plasmid-encoded chloramphenicol exporter that is found in Klebsiella aerogenes. PMID:9756755 cmlB cmlB1 is a plasmid-encoded chloramphenicol exporter that is found in Bordetella bronchiseptica. cmlB1 antibiotic_resistance ARO:3002699 cmlB1 ARO:3002699 cmlB1 is a plasmid-encoded chloramphenicol exporter that is found in Bordetella bronchiseptica. PMID:17224413 cmlB1 cmlv is a chromosome-encoded chloramphenicol phoshotransferase that is found in Streptomyces venezuelae. PDB:1QHN cmlv antibiotic_resistance ARO:3002700 cmlv ARO:3002700 cmlv is a chromosome-encoded chloramphenicol phoshotransferase that is found in Streptomyces venezuelae. PMID:7592948 cmlv cmr is a plasmid-encoded chloramphenicol exporter that is found in Rhodococcus fascians and Corynebacterium glutamicum. Rfas_cmr antibiotic_resistance ARO:3002701 Rhodococcus fascians cmr ARO:3002701 cmr is a plasmid-encoded chloramphenicol exporter that is found in Rhodococcus fascians and Corynebacterium glutamicum. PMID:1406276 Rfas_cmr cmrA is a transposon-encoded chloramphenicol exporter that is found in Rhodococcus rhodochrous. cmrA antibiotic_resistance ARO:3002702 cmrA ARO:3002702 cmrA is a transposon-encoded chloramphenicol exporter that is found in Rhodococcus rhodochrous. PMID:9226278 cmrA cmx is a plasmid or transposon-encoded chloramphenicol exporter that is found in Corynebacterium striatum and Pseudomonas aeruginosa. cmx antibiotic_resistance ARO:3002703 cmx ARO:3002703 cmx is a plasmid or transposon-encoded chloramphenicol exporter that is found in Corynebacterium striatum and Pseudomonas aeruginosa. PMID:8834878 PMID:9735314 cmx fexA is a plasmid-encoded chloramphenicol exporter that is found in Mammaliicoccus lentus. fexA antibiotic_resistance ARO:3002704 fexA ARO:3002704 fexA is a plasmid-encoded chloramphenicol exporter that is found in Mammaliicoccus lentus. PMID:14742219 fexA floR is a plasmid or chromosome-encoded chloramphenicol exporter that is found in Bordetella bronchiseptica, Escherichia coli, Klebsiella pneumoniae, Salmonella enterica subsp. enterica serovar Typhimurium str. DT104 and Vibrio cholerae. floR antibiotic_resistance ARO:3002705 floR ARO:3002705 floR is a plasmid or chromosome-encoded chloramphenicol exporter that is found in Bordetella bronchiseptica, Escherichia coli, Klebsiella pneumoniae, Salmonella enterica subsp. enterica serovar Typhimurium str. DT104 and Vibrio cholerae. PMID:10339826 PMID:10991873 PMID:11101601 PMID:11451703 PMID:11544236 PMID:11600347 PMID:12107144 PMID:12493808 PMID:14645321 PMID:17224413 PMID:19292580 floR Mycobacterium tuberculosis embC mutations at codon 270 confer resistance to ethambutol. antibiotic_resistance ARO:3002706 ethambutol resistant embC ARO:3002706 Mycobacterium tuberculosis embC mutations at codon 270 confer resistance to ethambutol. PMID:19112008 QnrA1 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. QnrA1 antibiotic_resistance ARO:3002707 QnrA1 ARO:3002707 QnrA1 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. PMID:11943863 QnrA1 QnrA2 is a plasmid-mediated quinolone resistance protein found in Klebsiella oxytoca. QnrA2 antibiotic_resistance ARO:3002708 QnrA2 ARO:3002708 QnrA2 is a plasmid-mediated quinolone resistance protein found in Klebsiella oxytoca. PMID:16020539 QnrA2 QnrA3 is a plasmid-mediated quinolone resistance protein found in Shewanella algae. QnrA3 antibiotic_resistance ARO:3002709 QnrA3 ARO:3002709 QnrA3 is a plasmid-mediated quinolone resistance protein found in Shewanella algae. PMID:16048974 QnrA3 QnrA4 is a plasmid-mediated quinolone resistance protein found in Shewanella algae. QnrA4 antibiotic_resistance ARO:3002710 QnrA4 ARO:3002710 QnrA4 is a plasmid-mediated quinolone resistance protein found in Shewanella algae. PMID:16048974 QnrA4 QnrA5 is a plasmid-mediated quinolone resistance protein found in Shewanella algae. QnrA5 antibiotic_resistance ARO:3002711 QnrA5 ARO:3002711 QnrA5 is a plasmid-mediated quinolone resistance protein found in Shewanella algae. PMID:16048974 QnrA5 QnrA6 is a plasmid-mediated quinolone resistance protein found in Proteus mirabilis. QnrA6 antibiotic_resistance ARO:3002712 QnrA6 ARO:3002712 QnrA6 is a plasmid-mediated quinolone resistance protein found in Proteus mirabilis. PMID:16961639 QnrA6 QnrA7 is a plasmid-mediated quinolone resistance protein found in Shewanella algae. QnrA7 antibiotic_resistance ARO:3002713 QnrA7 ARO:3002713 QnrA7 is a plasmid-mediated quinolone resistance protein found in Shewanella algae. PMID:34914577 QnrA7 QnrB1 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. QnrB1 antibiotic_resistance ARO:3002714 QnrB1 ARO:3002714 QnrB1 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. PMID:16569827 QnrB1 QnrB2 is a plasmid-mediated quinolone resistance protein found in Citrobacter koseri. QnrB2 antibiotic_resistance ARO:3002715 QnrB2 ARO:3002715 QnrB2 is a plasmid-mediated quinolone resistance protein found in Citrobacter koseri. PMID:16569827 QnrB2 QnrB3 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. QnrB3 antibiotic_resistance ARO:3002716 QnrB3 ARO:3002716 QnrB3 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. PMID:16870791 QnrB3 QnrB4 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. QnrB4 antibiotic_resistance ARO:3002718 QnrB4 ARO:3002718 QnrB4 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. PMID:16870791 QnrB4 QnrB5 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica. QnrB5 antibiotic_resistance ARO:3002719 QnrB5 ARO:3002719 QnrB5 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica. PMID:16804843 QnrB5 QnrB6 is a plasmid-mediated quinolone resistance protein found in Pantoea agglomerans. QnrB6 antibiotic_resistance ARO:3002720 QnrB6 ARO:3002720 QnrB6 is a plasmid-mediated quinolone resistance protein found in Pantoea agglomerans. PMID:19392890 QnrB6 QnrB7 is a plasmid-mediated quinolone resistance protein found in Enterobacter cloacae. QnrB7 antibiotic_resistance ARO:3002721 QnrB7 ARO:3002721 QnrB7 is a plasmid-mediated quinolone resistance protein found in Enterobacter cloacae. PMID:17561500 QnrB7 QnrB8 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB8 antibiotic_resistance ARO:3002722 QnrB8 ARO:3002722 QnrB8 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:17561500 QnrB8 QnrB9 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB9 antibiotic_resistance ARO:3002723 QnrB9 ARO:3002723 QnrB9 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:24093472 QnrB9 QnrB10 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB10 antibiotic_resistance ARO:3002724 QnrB10 ARO:3002724 QnrB10 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:17938184 QnrB10 QnrB11 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB11 antibiotic_resistance ARO:3002725 QnrB11 ARO:3002725 QnrB11 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:18426894 QnrB11 QnrB12 is a plasmid-mediated quinolone resistance protein found in Citrobacter werkmanii. QnrB12 antibiotic_resistance ARO:3002726 QnrB12 ARO:3002726 QnrB12 is a plasmid-mediated quinolone resistance protein found in Citrobacter werkmanii. PMID:18086833 QnrB12 QnrB13 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB13 antibiotic_resistance ARO:3002727 QnrB13 ARO:3002727 QnrB13 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:18725444 QnrB13 QnrB14 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB14 antibiotic_resistance ARO:3002728 QnrB14 ARO:3002728 QnrB14 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:18725444 QnrB14 QnrB15 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB15 antibiotic_resistance ARO:3002730 QnrB15 ARO:3002730 QnrB15 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:18725444 QnrB15 QnrB16 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB16 antibiotic_resistance ARO:3002731 QnrB16 ARO:3002731 QnrB16 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:19392890 QnrB16 QnrB17 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB17 antibiotic_resistance ARO:3002732 QnrB17 ARO:3002732 QnrB17 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:22850691 QnrB17 QnrB18 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB18 antibiotic_resistance ARO:3002733 QnrB18 ARO:3002733 QnrB18 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:22731858 QnrB18 QnrB19 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. QnrB19 antibiotic_resistance ARO:3002734 QnrB19 ARO:3002734 QnrB19 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. PMID:18519717 QnrB19 QnrB20 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. QnrB20 antibiotic_resistance ARO:3002735 QnrB20 ARO:3002735 QnrB20 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. PMID:18993034 QnrB20 QnrB21 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. QnrB21 antibiotic_resistance ARO:3002736 QnrB21 ARO:3002736 QnrB21 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. PMID:18426894 QnrB21 QnrB22 is a plasmid-mediated quinolone resistance protein found in Citrobacter werkmanii. QnrB22 antibiotic_resistance ARO:3002737 QnrB22 ARO:3002737 QnrB22 is a plasmid-mediated quinolone resistance protein found in Citrobacter werkmanii. PMID:20421404 QnrB22 QnrB23 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB23 antibiotic_resistance ARO:3002738 QnrB23 ARO:3002738 QnrB23 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:20421404 QnrB23 QnrB24 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB24 antibiotic_resistance ARO:3002739 QnrB24 ARO:3002739 QnrB24 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:21816943 QnrB24 QnrB25 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB25 antibiotic_resistance ARO:3002740 QnrB25 ARO:3002740 QnrB25 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:22850691 QnrB25 QnrB26 is a plasmid-mediated quinolone resistance protein found in Proteus vulgaris. QnrB26 antibiotic_resistance ARO:3002741 QnrB26 ARO:3002741 QnrB26 is a plasmid-mediated quinolone resistance protein found in Proteus vulgaris. PMID:23844849 QnrB26 QnrB27 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. QnrB27 antibiotic_resistance ARO:3002742 QnrB27 ARO:3002742 QnrB27 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. PMID:21830908 QnrB27 QnrB28 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB28 antibiotic_resistance ARO:3002743 QnrB28 ARO:3002743 QnrB28 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:21830908 QnrB28 QnrB29 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB29 antibiotic_resistance ARO:3002744 QnrB29 ARO:3002744 QnrB29 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:21830908 QnrB29 QnrB30 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. QnrB30 antibiotic_resistance ARO:3002745 QnrB30 ARO:3002745 QnrB30 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. PMID:21830908 QnrB30 QnrB31 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. QnrB31 antibiotic_resistance ARO:3002746 QnrB31 ARO:3002746 QnrB31 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. PMID:21816942 QnrB31 QnrB32 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB32 antibiotic_resistance ARO:3002747 QnrB32 ARO:3002747 QnrB32 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:21844311 QnrB32 QnrB33 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. QnrB33 antibiotic_resistance ARO:3002748 QnrB33 ARO:3002748 QnrB33 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. PMID:21844311 QnrB33 QnrB34 is a plasmid-mediated quinolone resistance protein found in Citrobacter werkmanii. QnrB34 antibiotic_resistance ARO:3002749 QnrB34 ARO:3002749 QnrB34 is a plasmid-mediated quinolone resistance protein found in Citrobacter werkmanii. PMID:21844311 QnrB34 QnrB35 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB35 antibiotic_resistance ARO:3002750 QnrB35 ARO:3002750 QnrB35 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:21844311 QnrB35 QnrB36 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB36 antibiotic_resistance ARO:3002751 QnrB36 ARO:3002751 QnrB36 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:21844311 QnrB36 QnrB37 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB37 antibiotic_resistance ARO:3002752 QnrB37 ARO:3002752 QnrB37 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:21844311 QnrB37 QnrB38 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB38 antibiotic_resistance ARO:3002753 QnrB38 ARO:3002753 QnrB38 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:21844311 QnrB38 QnrB39 is a chromosome-mediated quinolone resistance protein found in Citrobacter youngae. QnrB39 antibiotic_resistance ARO:3002754 QnrB39 ARO:3002754 QnrB39 is a chromosome-mediated quinolone resistance protein found in Citrobacter youngae. PMID:21844311 QnrB39 QnrB40 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. QnrB40 antibiotic_resistance ARO:3002755 QnrB40 ARO:3002755 QnrB40 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. PMID:21830908 QnrB40 QnrB41 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB41 antibiotic_resistance ARO:3002756 QnrB41 ARO:3002756 QnrB41 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:21830908 QnrB41 QnrB42 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. QnrB42 antibiotic_resistance ARO:3002757 QnrB42 ARO:3002757 QnrB42 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. PMID:22850691 QnrB42 QnrB43 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. QnrB43 antibiotic_resistance ARO:3002758 QnrB43 ARO:3002758 QnrB43 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. PMID:23162539 QnrB43 QnrB44 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. QnrB44 antibiotic_resistance ARO:3002759 QnrB44 ARO:3002759 QnrB44 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. PMID:26207437 QnrB44 QnrB45 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. QnrB45 antibiotic_resistance ARO:3002760 QnrB45 ARO:3002760 QnrB45 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. PMID:23162539 QnrB45 QnrB46 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. QnrB46 QnrB53 antibiotic_resistance ARO:3002761 QnrB46 ARO:3002761 QnrB46 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. PMID:21816942 QnrB46 QnrB47 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. QnrB47 QnrB51 antibiotic_resistance ARO:3002762 QnrB47 ARO:3002762 QnrB47 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. PMID:24247140 QnrB47 QnrB48 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB48 antibiotic_resistance ARO:3002763 QnrB48 ARO:3002763 QnrB48 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:23162539 QnrB48 QnrB49 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB49 antibiotic_resistance ARO:3002764 QnrB49 ARO:3002764 QnrB49 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:22731858 QnrB49 QnrB50 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB50 antibiotic_resistance ARO:3002765 QnrB50 ARO:3002765 QnrB50 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:23162539 QnrB50 QnrB54 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB54 antibiotic_resistance ARO:3002767 QnrB54 ARO:3002767 QnrB54 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:25512409 QnrB54 QnrB55 is a plasmid-mediated quinolone resistance protein found in Raoultella terrigena. QnrB55 antibiotic_resistance ARO:3002768 QnrB55 ARO:3002768 QnrB55 is a plasmid-mediated quinolone resistance protein found in Raoultella terrigena. PMID:27192164 QnrB55 QnrB56 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB56 antibiotic_resistance ARO:3002769 QnrB56 ARO:3002769 QnrB56 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:26169406 QnrB56 QnrB57 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB57 antibiotic_resistance ARO:3002770 QnrB57 ARO:3002770 QnrB57 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:26169406 QnrB57 QnrB58 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB58 antibiotic_resistance ARO:3002771 QnrB58 ARO:3002771 QnrB58 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:26169406 QnrB58 QnrB59 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB59 antibiotic_resistance ARO:3002772 QnrB59 ARO:3002772 QnrB59 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:18426894 QnrB59 QnrB60 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB60 antibiotic_resistance ARO:3002773 QnrB60 ARO:3002773 QnrB60 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:23529729 QnrB60 QnrB61 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. QnrB61 antibiotic_resistance ARO:3002774 QnrB61 ARO:3002774 QnrB61 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. PMID:23529729 QnrB61 QnrB62 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB62 antibiotic_resistance ARO:3002775 QnrB62 ARO:3002775 QnrB62 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:27572415 QnrB62 QnrB64 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB64 antibiotic_resistance ARO:3002776 QnrB64 ARO:3002776 QnrB64 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:24247140 QnrB64 QnrB65 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB65 antibiotic_resistance ARO:3002777 QnrB65 ARO:3002777 QnrB65 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:24247140 QnrB65 QnrB66 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB66 antibiotic_resistance ARO:3002778 QnrB66 ARO:3002778 QnrB66 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:24247140 QnrB66 QnrB67 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. QnrB67 antibiotic_resistance ARO:3002779 QnrB67 ARO:3002779 QnrB67 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. PMID:24247140 QnrB67 QnrB68 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. QnrB68 antibiotic_resistance ARO:3002780 QnrB68 ARO:3002780 QnrB68 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. PMID:24247140 QnrB68 QnrB69 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB69 antibiotic_resistance ARO:3002781 QnrB69 ARO:3002781 QnrB69 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:24247140 QnrB69 QnrB70 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB70 antibiotic_resistance ARO:3002782 QnrB70 ARO:3002782 QnrB70 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:24247140 QnrB70 QnrB71 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. QnrB71 antibiotic_resistance ARO:3002783 QnrB71 ARO:3002783 QnrB71 is a plasmid-mediated quinolone resistance protein found in Citrobacter braakii. PMID:24247140 QnrB71 QnrB72 is a plasmid-mediated quinolone resistance protein found in Citrobacter sp. TR21_24. QnrB72 antibiotic_resistance ARO:3002784 QnrB72 ARO:3002784 QnrB72 is a plasmid-mediated quinolone resistance protein found in Citrobacter sp. TR21_24. PMID:26169406 QnrB72 QnrB73 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. QnrB73 antibiotic_resistance ARO:3002785 QnrB73 ARO:3002785 QnrB73 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. PMID:26169406 QnrB73 QnrB74 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. QnrB74 antibiotic_resistance ARO:3002786 QnrB74 ARO:3002786 QnrB74 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. PMID:26259681 QnrB74 QnrC is a plasmid-mediated quinolone resistance protein found in Proteus mirabilis. QnrC antibiotic_resistance ARO:3002787 QnrC ARO:3002787 QnrC is a plasmid-mediated quinolone resistance protein found in Proteus mirabilis. PMID:19258263 QnrC QnrD1 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica. QnrD1 antibiotic_resistance ARO:3002788 QnrD1 ARO:3002788 QnrD1 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica. PMID:19029321 QnrD1 QnrD2 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica. QnrD2 antibiotic_resistance ARO:3002789 QnrD2 ARO:3002789 QnrD2 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica. PMID:24733466 QnrD2 QnrS1 is a plasmid-mediated quinolone resistance protein found in Shigella flexneri. QnrS1 antibiotic_resistance ARO:3002790 QnrS1 ARO:3002790 QnrS1 is a plasmid-mediated quinolone resistance protein found in Shigella flexneri. PMID:15673773 QnrS1 QnrS2 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica. QnrS2 antibiotic_resistance ARO:3002791 QnrS2 ARO:3002791 QnrS2 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica. PMID:16804843 QnrS2 QnrS3 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. QnrS3 antibiotic_resistance ARO:3002792 QnrS3 ARO:3002792 QnrS3 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. PMID:18573620 QnrS3 QnrS4 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica. QnrS4 antibiotic_resistance ARO:3002793 QnrS4 ARO:3002793 QnrS4 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica. PMID:19056747 QnrS4 QnrS5 is a plasmid-mediated quinolone resistance protein found in Aeromonas sobria. QnrS5 antibiotic_resistance ARO:3002794 QnrS5 ARO:3002794 QnrS5 is a plasmid-mediated quinolone resistance protein found in Aeromonas sobria. PMID:22024339 QnrS5 QnrS6 is a plasmid-mediated quinolone resistance protein found in Aeromonas hydrophila. QnrS6 antibiotic_resistance ARO:3002795 QnrS6 ARO:3002795 QnrS6 is a plasmid-mediated quinolone resistance protein found in Aeromonas hydrophila. PMID:22024339 QnrS6 QnrS7 is a plasmid-mediated quinolone resistance protein found in Escherichia coli. QnrS7 antibiotic_resistance ARO:3002796 QnrS7 ARO:3002796 QnrS7 QnrS8 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. QnrS8 antibiotic_resistance ARO:3002797 QnrS8 ARO:3002797 QnrS8 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. PMID:26618005 QnrS8 QnrS9 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. QnrS9 antibiotic_resistance ARO:3002798 QnrS9 ARO:3002798 QnrS9 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. PMID:24458509 QnrS9 QnrVC1 is an integron-mediated quinolone resistance protein found in Vibrio cholerae. QnrVC1 antibiotic_resistance ARO:3002799 QnrVC1 ARO:3002799 QnrVC1 is an integron-mediated quinolone resistance protein found in Vibrio cholerae. PMID:18598639 QnrVC1 QnrVC3 is an integron-mediated quinolone resistance protein found in Vibrio cholerae. QnrVC3 antibiotic_resistance ARO:3002800 QnrVC3 ARO:3002800 QnrVC3 is an integron-mediated quinolone resistance protein found in Vibrio cholerae. PMID:20516288 QnrVC3 QnrVC4 is an integron-mediated quinolone resistance protein found in Aeromonas punctata. QnrVC4 antibiotic_resistance ARO:3002801 QnrVC4 ARO:3002801 QnrVC4 is an integron-mediated quinolone resistance protein found in Aeromonas punctata. PMID:23098826 QnrVC4 QnrVC5 is an integron-mediated quinolone resistance protein found in Vibrio fluvialis. QnrVC5 antibiotic_resistance ARO:3002802 QnrVC5 ARO:3002802 QnrVC5 is an integron-mediated quinolone resistance protein found in Vibrio fluvialis. PMID:23800600 QnrVC5 QnrVC6 is an integron-mediated quinolone resistance protein found in Acinetobacter baumannii. QnrVC6 antibiotic_resistance ARO:3002803 QnrVC6 ARO:3002803 QnrVC6 is an integron-mediated quinolone resistance protein found in Acinetobacter baumannii. PMID:23800600 QnrVC6 An enzyme that confers resistance to fosfomycin in Enterobacter cloacae by breaking the epoxide ring of the molecule. It depends on the cofactors Manganese (II) and Potassium and uses Glutathione (GSH) as the nucleophilic molecule. FosA2 antibiotic_resistance ARO:3002804 FosA2 ARO:3002804 An enzyme that confers resistance to fosfomycin in Enterobacter cloacae by breaking the epoxide ring of the molecule. It depends on the cofactors Manganese (II) and Potassium and uses Glutathione (GSH) as the nucleophilic molecule. PMID:21392044 FosA2 murA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Overexpression of murA through mutations confers fosfomycin resistance. antibiotic_resistance ARO:3002811 antibiotic-resistant murA transferase ARO:3002811 murA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Overexpression of murA through mutations confers fosfomycin resistance. PMID:20071153 pp-flo is a plasmid chloramphenicol exporter that is found in Photobacterium damselae subsp. piscicida. pp-flo antibiotic_resistance ARO:3002812 pp-flo ARO:3002812 pp-flo is a plasmid chloramphenicol exporter that is found in Photobacterium damselae subsp. piscicida. PMID:8908612 pp-flo lmrB is a chromosomally-encoded efflux pump that confers resistance to lincosamides in Bacillus subtilis. lmrB antibiotic_resistance ARO:3002813 lmrB ARO:3002813 lmrB is a chromosomally-encoded efflux pump that confers resistance to lincosamides in Bacillus subtilis. PMID:15317768 lmrB clbA is a plasmid-encoded cfr gene found in Bacillus velezensis (Bacillus amyloliquefaciens subsp. plantarum). clbA antibiotic_resistance ARO:3002814 clbA ARO:3002814 clbA is a plasmid-encoded cfr gene found in Bacillus velezensis (Bacillus amyloliquefaciens subsp. plantarum). PMID:22547628 clbA clbB is a plasmid-encoded cfr gene found in Bacillus brevis. clbB antibiotic_resistance ARO:3002815 clbB ARO:3002815 clbB is a plasmid-encoded cfr gene found in Bacillus brevis. PMID:22547628 PMID:29259290 clbB clbC is a plasmid-encoded cfr gene found in Alkalihalobacillus clausii. clbC antibiotic_resistance ARO:3002816 clbC ARO:3002816 clbC is a plasmid-encoded cfr gene found in Alkalihalobacillus clausii. PMID:22547628 clbC carA is an ABC-F subfamily protein involved in macrolide resistance. It is found in Streptomyces thermotolerans. carA antibiotic_resistance ARO:3002817 carA ARO:3002817 carA is an ABC-F subfamily protein involved in macrolide resistance. It is found in Streptomyces thermotolerans. PMID:1612454 carA MsrB is an ABC-F subfamily protein expressed to Staphylococcus species that confers resistance to erythromycin and streptogramin B antibiotics. It is associated with plasmid DNA. msr(B) msrB antibiotic_resistance ARO:3002818 msrB ARO:3002818 MsrB is an ABC-F subfamily protein expressed to Staphylococcus species that confers resistance to erythromycin and streptogramin B antibiotics. It is associated with plasmid DNA. PMID:1426997 msrB msrC is a chromosomal-encoded ABC-F subfamily protein expressed in Enterococcus faecium that confers resistance to erythromycin and other macrolide and streptogramin B antibiotics. msr(C) msrC antibiotic_resistance ARO:3002819 msrC ARO:3002819 msrC is a chromosomal-encoded ABC-F subfamily protein expressed in Enterococcus faecium that confers resistance to erythromycin and other macrolide and streptogramin B antibiotics. PMID:11120975 msrC ErmH is a plasmid-mediated methyltransferase found in Streptomyces thermotolerans. ErmH carB antibiotic_resistance ARO:3002823 ErmH ARO:3002823 ErmH is a plasmid-mediated methyltransferase found in Streptomyces thermotolerans. PMID:3036668 ErmH ErmV is a plasmid-mediated methyltransferase found in Streptomyces viridochromogenes. ErmV ermSV antibiotic_resistance ARO:3002824 ErmV ARO:3002824 ErmV is a plasmid-mediated methyltransferase found in Streptomyces viridochromogenes. PMID:6163765 PMID:9055987 ErmV ErmY is a plasmid-mediated methyltransferase found in Staphylococcus aureus. ErmGM ErmY antibiotic_resistance ARO:3002825 ErmY ARO:3002825 ErmY is a plasmid-mediated methyltransferase found in Staphylococcus aureus. PMID:9809423 ErmY EreA2 is an integron-encoded erythromycin esterase that hydrolyses the drug's lactone ring. EreA2 is found in Providencia stuartii. Ere(A2) EreA2 antibiotic_resistance ARO:3002826 EreA2 ARO:3002826 EreA2 is an integron-encoded erythromycin esterase that hydrolyses the drug's lactone ring. EreA2 is found in Providencia stuartii. PMID:12654734 EreA2 tlrC is an ABC-F subfamily protein found in Streptomyces fradiae and confers resistance to mycinamicin, tylosin and lincosamides. tlrC is found in the tylosin biosynthetic cluster and is one mechanism by which S. fradiae protects itself from self-destruction when producing this macrolide. tlrC antibiotic_resistance ARO:3002827 tlrC ARO:3002827 tlrC is an ABC-F subfamily protein found in Streptomyces fradiae and confers resistance to mycinamicin, tylosin and lincosamides. tlrC is found in the tylosin biosynthetic cluster and is one mechanism by which S. fradiae protects itself from self-destruction when producing this macrolide. PMID:1864505 tlrC srmB is an ABC-F subfamily protein found in Streptomyces ambofaciens that confers resistance to spiramycin. srmB antibiotic_resistance ARO:3002828 srmB ARO:3002828 srmB is an ABC-F subfamily protein found in Streptomyces ambofaciens that confers resistance to spiramycin. PMID:1612454 srmB vgaA is an ABC-F subfamily protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA. vgaA antibiotic_resistance ARO:3002829 vgaA ARO:3002829 vgaA is an ABC-F subfamily protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA. PMID:23796922 vgaA vgaALC is an ABC-F subfamily protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA. vgaALC antibiotic_resistance ARO:3002830 vgaALC ARO:3002830 vgaALC is an ABC-F subfamily protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA. PMID:17015629 vgaALC vgaC is an ABC-F subfamily protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA. vgaC antibiotic_resistance ARO:3002831 vgaC ARO:3002831 vgaC is an ABC-F subfamily protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA. PMID:19470508 PMID:20876620 vgaC vgaD is an ABC-F subfamily protein expressed in Enterococcus faecium that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA. vgaD antibiotic_resistance ARO:3002832 vgaD ARO:3002832 vgaD is an ABC-F subfamily protein expressed in Enterococcus faecium that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA. PMID:20713681 vgaD vgaE is an ABC-F subfamily protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with transposon DNA. vgaE antibiotic_resistance ARO:3002833 vgaE ARO:3002833 vgaE is an ABC-F subfamily protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with transposon DNA. PMID:21768510 vgaE lnuA is a plasmid-mediated nucleotidyltransferase found in Staphylococcus chromogenes. linA lnuA antibiotic_resistance ARO:3002835 lnuA ARO:3002835 lnuA is a plasmid-mediated nucleotidyltransferase found in Staphylococcus chromogenes. PMID:17329268 lnuA lnuB is a plasmid-mediated nucleotidyltransferase found in Streptococcus lutetiensis. linB lnuB antibiotic_resistance ARO:3002836 lnuB ARO:3002836 lnuB is a plasmid-mediated nucleotidyltransferase found in Streptococcus lutetiensis. PMID:10103201 PMID:24048528 lnuB lnuC is a transposon-mediated nucleotidyltransferase found in Streptococcus agalactiae. linC lnuC antibiotic_resistance ARO:3002837 lnuC ARO:3002837 lnuC is a transposon-mediated nucleotidyltransferase found in Streptococcus agalactiae. PMID:15980341 lnuC lnuD is a plasmid-mediated nucleotidyltransferase found in Streptococcus uberis. linD lnuD antibiotic_resistance ARO:3002838 lnuD ARO:3002838 lnuD is a plasmid-mediated nucleotidyltransferase found in Streptococcus uberis. PMID:18086844 lnuD lnuF is an integron-mediated nucleotidyltransferase found in Escherichia coli. linF lnuF antibiotic_resistance ARO:3002839 lnuF ARO:3002839 lnuF is an integron-mediated nucleotidyltransferase found in Escherichia coli. PMID:15242512 lnuF vatA is a plasmid-mediated acetyltransferase found in Staphylococcus aureus. vat(A) vatA antibiotic_resistance ARO:3002840 vatA ARO:3002840 vatA is a plasmid-mediated acetyltransferase found in Staphylococcus aureus. PMID:8344533 vatA vatB is a plasmid-mediated acetyltransferase found in Staphylococcus aureus. vat(B) vatB antibiotic_resistance ARO:3002841 vatB ARO:3002841 vatB is a plasmid-mediated acetyltransferase found in Staphylococcus aureus. PMID:8540711 vatB vatC is a plasmid-mediated acetyltransferase found in Staphylococcus cohnii. vat(C) vatC antibiotic_resistance ARO:3002842 vatC ARO:3002842 vatC is a plasmid-mediated acetyltransferase found in Staphylococcus cohnii. PMID:9661023 vatC vatD is a transposon-mediated acetyltransferase found in Enterococcus faecium. vat(D) vatD antibiotic_resistance ARO:3002843 vatD ARO:3002843 vatD is a transposon-mediated acetyltransferase found in Enterococcus faecium. PMID:11600385 vatD vatE is a transposon-mediated acetyltransferase found in Enterococcus faecium. satG vat(E) vatE antibiotic_resistance ARO:3002844 vatE ARO:3002844 vatE is a transposon-mediated acetyltransferase found in Enterococcus faecium. PMID:11023445 vatE vatH is a plasmid-mediated acetyltransferase found in Enterococcus faecium. vatG vatH antibiotic_resistance ARO:3002845 vatH ARO:3002845 vatH is a plasmid-mediated acetyltransferase found in Enterococcus faecium. PMID:20713681 vatH arr-1 is a chromosome-encoded ribosyltransferase found in Mycolicibacterium smegmatis. arr-1 antibiotic_resistance ARO:3002846 arr-1 ARO:3002846 arr-1 is a chromosome-encoded ribosyltransferase found in Mycolicibacterium smegmatis. PMID:9371349 arr-1 arr-2 is an integron-encoded ribosyltransferase found in Pseudomonas aeruginosa. arr-2 antibiotic_resistance ARO:3002847 arr-2 ARO:3002847 arr-2 is an integron-encoded ribosyltransferase found in Pseudomonas aeruginosa. PMID:10103210 arr-2 arr-3 is a plasmid-encoded ribosyltransferase found in Vibrio fluvialis. arr-3 arr-6 antibiotic_resistance ARO:3002848 arr-3 ARO:3002848 arr-3 is a plasmid-encoded ribosyltransferase found in Vibrio fluvialis. PMID:21683552 arr-3 arr-4 is an integron-encoded ribosyltransferase found in Pseudomonas aeruginosa. arr-4 antibiotic_resistance ARO:3002849 arr-4 ARO:3002849 arr-4 is an integron-encoded ribosyltransferase found in Pseudomonas aeruginosa. PMID:18299416 arr-4 arr-5 is an integron-encoded ribosyltransferase found in Pseudomonas aeruginosa. arr-5 antibiotic_resistance ARO:3002850 arr-5 ARO:3002850 arr-5 is an integron-encoded ribosyltransferase found in Pseudomonas aeruginosa. PMID:18299416 arr-5 arr-7 is an integron-encoded ribosyltransferase found in Pseudomonas aeruginosa. arr-7 antibiotic_resistance ARO:3002852 arr-7 ARO:3002852 arr-7 is an integron-encoded ribosyltransferase found in Pseudomonas aeruginosa. PMID:19884381 arr-7 arr-8 is an integron-encoded ribosyltransferase found in Klebsiella oxytoca. arr-8 antibiotic_resistance ARO:3002853 arr-8 ARO:3002853 arr-8 is an integron-encoded ribosyltransferase found in Klebsiella oxytoca. PMID:23752512 arr-8 dfrA1 is an integron-encoded dihydrofolate reductase. dfr1 dfrA1 dhfrI antibiotic_resistance ARO:3002854 dfrA1 ARO:3002854 dfrA1 is an integron-encoded dihydrofolate reductase. PMID:15388464 dfrA1 dfrA24 is an integron-encoded dihydrofolate reductase found in Escherichia coli. dfrA24 antibiotic_resistance ARO:3002856 dfrA24 ARO:3002856 dfrA24 is an integron-encoded dihydrofolate reductase found in Escherichia coli. PMID:17307981 dfrA24 dfrA26 is an integron-encoded dihydrofolate reductase found in Escherichia coli. dfrA26 antibiotic_resistance ARO:3002857 dfrA26 ARO:3002857 dfrA26 is an integron-encoded dihydrofolate reductase found in Escherichia coli. PMID:17307981 dfrA26 dfrA12 is an integron-encoded dihydrofolate reductase found in Vibrio cholerae. dfrA12 antibiotic_resistance ARO:3002858 dfrA12 ARO:3002858 dfrA12 is an integron-encoded dihydrofolate reductase found in Vibrio cholerae. PMID:12183252 PMID:20660690 dfrA12 dfrA14 is an integron-encoded dihydrofolate reductase found in Escherichia coli. dfrA14 antibiotic_resistance ARO:3002859 dfrA14 ARO:3002859 dfrA14 is an integron-encoded dihydrofolate reductase found in Escherichia coli. PMID:18794381 dfrA14 dfrA17 is an integron-encoded dihydrofolate reductase found in Escherichia coli. dfrA17 antibiotic_resistance ARO:3002860 dfrA17 ARO:3002860 dfrA17 is an integron-encoded dihydrofolate reductase found in Escherichia coli. PMID:20236427 dfrA17 dfrA5 is an integron-encoded dihydrofolate reductase found in Vibrio cholerae. dfrA5 antibiotic_resistance ARO:3002861 dfrA5 ARO:3002861 dfrA5 is an integron-encoded dihydrofolate reductase found in Vibrio cholerae. PMID:12183252 dfrA5 dfrA7 is an integron-encoded dihydrofolate reductase found in Escherichia coli. dfrA7 antibiotic_resistance ARO:3002862 dfrA7 ARO:3002862 dfrA7 is an integron-encoded dihydrofolate reductase found in Escherichia coli. PMID:19229487 dfrA7 dfrA8 is a transposon-encoded dihydrofolate reductase found in Salmonella enterica. dfrA8 dhfrIIIc antibiotic_resistance ARO:3002863 dfrA8 ARO:3002863 dfrA8 is a transposon-encoded dihydrofolate reductase found in Salmonella enterica. PMID:32849452 dfrA8 A plasmid-associated trimethoprim-resistant dihydrofolate reductase detected in Bordetella bronchispetica on pKBB958. dfr2a dfrB1 dfrII antibiotic_resistance ARO:3002864 dfrB1 ARO:3002864 A plasmid-associated trimethoprim-resistant dihydrofolate reductase detected in Bordetella bronchispetica on pKBB958. PMID:16046466 dfrB1 dfrC is a chromosome-encoded dihydrofolate reductase found in Staphylococcus aureus. dfrC antibiotic_resistance ARO:3002865 dfrC ARO:3002865 dfrC is a chromosome-encoded dihydrofolate reductase found in Staphylococcus aureus. PMID:7768789 dfrC dfrD is a plasmid-encoded dihydrofolate reductase found in Listeria monocytogenes. dfrD antibiotic_resistance ARO:3002866 dfrD ARO:3002866 dfrD is a plasmid-encoded dihydrofolate reductase found in Listeria monocytogenes. PMID:9145882 dfrD dfrF is a chromosome-encoded dihydrofolate reductase found in Streptococcus pyogenes. dfrF antibiotic_resistance ARO:3002867 dfrF ARO:3002867 dfrF is a chromosome-encoded dihydrofolate reductase found in Streptococcus pyogenes. PMID:24492367 dfrF dfrG is a plasmid-encoded dihydrofolate reductase found in Staphylococcus aureus. dfrG antibiotic_resistance ARO:3002868 dfrG ARO:3002868 dfrG is a plasmid-encoded dihydrofolate reductase found in Staphylococcus aureus. PMID:16127079 dfrG dfrK is a plasmid-encoded dihydrofolate reductase found in Staphylococcus aureus. dfrK antibiotic_resistance ARO:3002869 dfrK ARO:3002869 dfrK is a plasmid-encoded dihydrofolate reductase found in Staphylococcus aureus. PMID:22718530 dfrK tet(34) causes the activation of Mg2+-dependent purine nucleotide synthesis, which protects the protein synthesis pathway. It is found in Gram-negative Vibrio. tet(34) tet34 antibiotic_resistance ARO:3002870 tet(34) ARO:3002870 tet(34) causes the activation of Mg2+-dependent purine nucleotide synthesis, which protects the protein synthesis pathway. It is found in Gram-negative Vibrio. PMID:11959596 tet(34) tet(37) is a chromosome-encoded oxidoreductase isolated from an uncultured bacterium that confers resistance to tetracycline. tet(37) tet37 antibiotic_resistance ARO:3002871 tet(37) ARO:3002871 tet(37) is a chromosome-encoded oxidoreductase isolated from an uncultured bacterium that confers resistance to tetracycline. PMID:12654685 tet(37) An enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule. It depends on the cofactors Manganese (II) and Potassium and uses Glutathione (GSH) as the nucleophilic molecule. FosA3 antibiotic_resistance ARO:3002872 FosA3 ARO:3002872 An enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule. It depends on the cofactors Manganese (II) and Potassium and uses Glutathione (GSH) as the nucleophilic molecule. PMID:26488485 FosA3 A thiol transferase that leads to the resistance of fosfomycin in Enterococcus faecium. Contrasting FosA, FosB is dependent on the cofactor Magnesium (II) and uses either bacillithiol to open up the epoxide ring of fosfomycin. FosB3 antibiotic_resistance ARO:3002873 FosB3 ARO:3002873 A thiol transferase that leads to the resistance of fosfomycin in Enterococcus faecium. Contrasting FosA, FosB is dependent on the cofactor Magnesium (II) and uses either bacillithiol to open up the epoxide ring of fosfomycin. PMID:24205114 FosB3 FosC2 is an enzyme that phosphorylates fosfomycin to confer resistance in Escherichia coli. FosC2 antibiotic_resistance ARO:3002874 FosC2 ARO:3002874 FosC2 is an enzyme that phosphorylates fosfomycin to confer resistance in Escherichia coli. PMID:20404116 FosC2 dfrE is a chromosome-encoded dihydrofolate reductase found in Enterococcus faecalis. dfrE antibiotic_resistance ARO:3002875 dfrE ARO:3002875 dfrE is a chromosome-encoded dihydrofolate reductase found in Enterococcus faecalis. PMID:9869579 dfrE Arabinofuranosyltransferases allow for the polymerization of arabinose to form arabinan. Arabinan is required for formation of mycobacterial cell walls and arabinosyltransferases are targets of the drug ethambutol. Mutations in these genes can confer resistance to ethambutol. antibiotic_resistance ARO:3002876 ethambutol resistant aftA ARO:3002876 Bacillus cereus beta-lactamase I is a class A beta-lactamase that breaks down a number of penicillins and cephalosporins in the Bacillus cereus strain 569/H/9. BcI antibiotic_resistance ARO:3002877 BcI ARO:3002877 Bacillus cereus beta-lactamase I is a class A beta-lactamase that breaks down a number of penicillins and cephalosporins in the Bacillus cereus strain 569/H/9. PMID:29551437 BcI Bacillus cereus beta-lactamase II is a zinc metallo-beta-lactamase that hydrolyzes a large number of penicillins and cephalosporins in the Bacillus cereus strain 5/B/6. BcII antibiotic_resistance ARO:3002878 BcII ARO:3002878 Bacillus cereus beta-lactamase II is a zinc metallo-beta-lactamase that hydrolyzes a large number of penicillins and cephalosporins in the Bacillus cereus strain 5/B/6. PMID:7588620 BcII linG is an integron-associated gene cassette, with aadA2, encoding a lincosomide nucleotidyltransferase found in Salmonella enterica. linG confers resistance to lincosomide antibiotics. linG antibiotic_resistance ARO:3002879 linG ARO:3002879 linG is an integron-associated gene cassette, with aadA2, encoding a lincosomide nucleotidyltransferase found in Salmonella enterica. linG confers resistance to lincosomide antibiotics. PMID:17005845 linG lmrC is an ABC-F subfamily protein that confers resistance to lincosamides in Streptomyces lincolnensis and Lactococcus lactis. It can dimerize with lmrD. lmrC ydaG antibiotic_resistance ARO:3002881 lmrC ARO:3002881 lmrC is an ABC-F subfamily protein that confers resistance to lincosamides in Streptomyces lincolnensis and Lactococcus lactis. It can dimerize with lmrD. PMID:16958846 lmrC lmrD is a chromosomally-encoded efflux pump that confers resistance to lincosamides in Streptomyces lincolnensis and Lactococcus lactis. It can dimerize with lmrC. lmrD ydbA antibiotic_resistance ARO:3002882 lmrD ARO:3002882 lmrD is a chromosomally-encoded efflux pump that confers resistance to lincosamides in Streptomyces lincolnensis and Lactococcus lactis. It can dimerize with lmrC. PMID:16958846 lmrD rgt1438 is a glycosyltransferase that confers rifampin resistance in Streptomyces. rgt1438 antibiotic_resistance ARO:3002883 rgt1438 ARO:3002883 rgt1438 is a glycosyltransferase that confers rifampin resistance in Streptomyces. PMID:22802246 rgt1438 iri is a monooxygenase that confers resistance to rifampin found in Rhodococcus hoagii. iri antibiotic_resistance ARO:3002884 iri ARO:3002884 iri is a monooxygenase that confers resistance to rifampin found in Rhodococcus hoagii. PMID:8980786 iri Streptomyces rimosus otr(A) is an oxytetracycline resistance ribosomal protection protein found in Streptomyces rimosus. otr(A)S.rim antibiotic_resistance ARO:3002891 Streptomyces rimosus otr(A) ARO:3002891 Streptomyces rimosus otr(A) is an oxytetracycline resistance ribosomal protection protein found in Streptomyces rimosus. PMID:1809836 otr(A)S.rim otr(B) is a tetracycline resistance efflux pump found in Streptomyces rimosus. otr(B) otrB tet347 antibiotic_resistance ARO:3002892 otr(B) ARO:3002892 otr(B) is a tetracycline resistance efflux pump found in Streptomyces rimosus. PMID:9867793 otr(B) tcr3 is a tetracycline efflux pump that confers self-resistance to Kitasatospora aureofaciens. tcr3 trcC antibiotic_resistance ARO:3002893 tcr3 ARO:3002893 tcr3 is a tetracycline efflux pump that confers self-resistance to Kitasatospora aureofaciens. PMID:8534971 tcr3 otr(C) is a tetracycline resistance efflux pump found in Streptomyces rimosus. otr(C) otrC antibiotic_resistance ARO:3002894 otr(C) ARO:3002894 otr(C) is a tetracycline resistance efflux pump found in Streptomyces rimosus. PMID:22906146 otr(C) SAT-2 is a plasmid-mediated streptothricin acetyltransferase, which confers resistance to streptothricin, a nucleoside antibiotic. Originally described from an E. coli plasmid sequence by Heim et al., 1989. SAT-2 antibiotic_resistance ARO:3002895 SAT-2 ARO:3002895 SAT-2 is a plasmid-mediated streptothricin acetyltransferase, which confers resistance to streptothricin, a nucleoside antibiotic. Originally described from an E. coli plasmid sequence by Heim et al., 1989. PMID:2157196 PMID:2550905 SAT-2 SAT-4 is a plasmid-mediated streptothricin acetyltransferase and streptothricin (a nucleoside antibiotic) resistant determinant. Originally described from a Campylobacter coli BE/G4 plasmid gene sequence by Jacob et al, 1994. SAT-4 antibiotic_resistance ARO:3002897 SAT-4 ARO:3002897 SAT-4 is a plasmid-mediated streptothricin acetyltransferase and streptothricin (a nucleoside antibiotic) resistant determinant. Originally described from a Campylobacter coli BE/G4 plasmid gene sequence by Jacob et al, 1994. PMID:8056285 SAT-4 SAT-3 is a plasmid-mediated streptothricin acetyltransferase and streptothricin resistance determinant. Originally described from an E. coli plasmid gene by Tietze and Brevet, 1995. SAT-3 antibiotic_resistance ARO:3002898 SAT-3 ARO:3002898 SAT-3 is a plasmid-mediated streptothricin acetyltransferase and streptothricin resistance determinant. Originally described from an E. coli plasmid gene by Tietze and Brevet, 1995. PMID:7640311 SAT-3 These genes are involved in activating and regulating transcription of gene clusters. antibiotic_resistance ARO:3002905 VanS-VanR two-component regulatory system ARO:3002905 These genes are involved in activating and regulating transcription of gene clusters. PMID:1556077 Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity. antibiotic_resistance ARO:3002906 Van ligase ARO:3002906 Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity. PMID:12019119 PMID:15980329 PMID:16323116 PMID:16723588 PMID:18458129 PMID:20733041 PMID:21807981 PMID:24342631 VanE is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis. vanE antibiotic_resistance ARO:3002907 vanE ARO:3002907 VanE is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis. PMID:12019119 vanE VanF is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance in Paenibacillus popilliae. vanF antibiotic_resistance ARO:3002908 vanF ARO:3002908 VanF is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance in Paenibacillus popilliae. PMID:15980329 vanF VanG is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis. vanG antibiotic_resistance ARO:3002909 vanG ARO:3002909 VanG is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis. PMID:12426332 PMID:16323116 vanG VanL is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis. vanL antibiotic_resistance ARO:3002910 vanL ARO:3002910 VanL is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis. PMID:18458129 vanL VanM is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance. vanM antibiotic_resistance ARO:3002911 vanM ARO:3002911 VanM is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance. PMID:20733041 vanM VanN is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecium. vanN antibiotic_resistance ARO:3002912 vanN ARO:3002912 VanN is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecium. PMID:21807981 vanN VanO is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance. vanO antibiotic_resistance ARO:3002913 vanO ARO:3002913 VanO is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance. PMID:24342631 vanO vanJ is a novel membrane protein that confers resistance to teicoplanin and its derivatives in Streptomyces coelicolor by recycling undecaprenol pyrophosphate during cell wall biosynthesis. vanJ antibiotic_resistance ARO:3002914 vanJ ARO:3002914 vanJ is a novel membrane protein that confers resistance to teicoplanin and its derivatives in Streptomyces coelicolor by recycling undecaprenol pyrophosphate during cell wall biosynthesis. PMID:15130128 PMID:22232274 vanJ VanK is a member of the Fem family of enzymes that add the cross-bridge amino acids to the stem pentapeptide of cell wall precursors in Streptomyces coelicolor that confers inducible, high-level vancomycin resistance. antibiotic_resistance ARO:3002915 vanK ARO:3002915 VanK is a member of the Fem family of enzymes that add the cross-bridge amino acids to the stem pentapeptide of cell wall precursors in Streptomyces coelicolor that confers inducible, high-level vancomycin resistance. PMID:15130128 PMID:15632111 vanV is an accessory protein of van operons, first identified in the vanB operon. It is not required for vancomycin resistance. antibiotic_resistance ARO:3002916 vanV ARO:3002916 vanV is an accessory protein of van operons, first identified in the vanB operon. It is not required for vancomycin resistance. PMID:21482081 Homologous to vanC, contains a D-Ala-D-Ser ligase. The plasmid-located vanM gene cluster is inducible and confers low resistance to vancomycin. vanN organisms remain susceptible to teicoplanin. Gene orientation: N(XY)TRS. vanN_cluster antibiotic_resistance ARO:3002917 glycopeptide resistance gene cluster VanN ARO:3002917 Homologous to vanC, contains a D-Ala-D-Ser ligase. The plasmid-located vanM gene cluster is inducible and confers low resistance to vancomycin. vanN organisms remain susceptible to teicoplanin. Gene orientation: N(XY)TRS. PMID:21807981 vanN_cluster Homologous to vanA, contains a D-Ala-D-Lac ligase. The chromosome-located vanO gene cluster is inducible. Not much is known about the biochemistry about the vanO gene cluster. Gene orientation: orf1 RS orf2 HOX. vanO_cluster antibiotic_resistance ARO:3002918 glycopeptide resistance gene cluster VanO ARO:3002918 Homologous to vanA, contains a D-Ala-D-Lac ligase. The chromosome-located vanO gene cluster is inducible. Not much is known about the biochemistry about the vanO gene cluster. Gene orientation: orf1 RS orf2 HOX. PMID:24342631 vanO_cluster Also known as vanRA, is a vanR variant found in the vanA gene cluster. vanR-A vanRA vanR_in_vanA_cl antibiotic_resistance ARO:3002919 vanR gene in vanA cluster ARO:3002919 Also known as vanRA, is a vanR variant found in the vanA gene cluster. PMID:16323116 PMID:8380148 vanR_in_vanA_cl Also known as vanRB, is a vanR variant found in the vanB gene cluster. vanR-B vanRB vanR_in_vanB_cl antibiotic_resistance ARO:3002921 vanR gene in vanB cluster ARO:3002921 Also known as vanRB, is a vanR variant found in the vanB gene cluster. PMID:16323116 PMID:8631706 vanR_in_vanB_cl Also known as vanRC, is a vanR variant found in the vanC gene cluster. vanR-C vanRC vanR_in_vanC_cl antibiotic_resistance ARO:3002922 vanR gene in vanC cluster ARO:3002922 Also known as vanRC, is a vanR variant found in the vanC gene cluster. PMID:10817725 PMID:16323116 vanR_in_vanC_cl Also known as vanRD, is a mutated vanR variant found in the vanD gene cluster that caused constitutive expression of vanD peptidoglycan synthesis. vanR-D vanRD vanR_in_vanD_cl antibiotic_resistance ARO:3002923 vanR gene in vanD cluster ARO:3002923 Also known as vanRD, is a mutated vanR variant found in the vanD gene cluster that caused constitutive expression of vanD peptidoglycan synthesis. PMID:12499162 PMID:16323116 vanR_in_vanD_cl Also known as vanRE, is a vanR variant found in the vanE gene cluster. vanR-E vanRE vanR_in_vanE_cl antibiotic_resistance ARO:3002924 vanR gene in vanE cluster ARO:3002924 Also known as vanRE, is a vanR variant found in the vanE gene cluster. PMID:12019119 vanR_in_vanE_cl Also known as vanRF, is a vanR variant found in the vanF gene cluster. vanR-F vanRF vanR_in_vanF_cl antibiotic_resistance ARO:3002925 vanR gene in vanF cluster ARO:3002925 Also known as vanRF, is a vanR variant found in the vanF gene cluster. PMID:15980329 vanR_in_vanF_cl Also known as vanRG, is a vanR variant found in the vanG gene cluster. vanR-G vanRG vanR_in_vanG_cl antibiotic_resistance ARO:3002926 vanR gene in vanG cluster ARO:3002926 Also known as vanRG, is a vanR variant found in the vanG gene cluster. PMID:16723588 vanR_in_vanG_cl Also known as vanRL, is a vanR variant found in the vanL gene cluster. vanR-L vanRL vanR_in_vanL_cl antibiotic_resistance ARO:3002927 vanR gene in vanL cluster ARO:3002927 Also known as vanRL, is a vanR variant found in the vanL gene cluster. PMID:18458129 vanR_in_vanL_cl Also known as vanRM, is a vanR variant found in the vanM gene cluster. vanR-M vanRM vanR_in_vanM_cl antibiotic_resistance ARO:3002928 vanR gene in vanM cluster ARO:3002928 Also known as vanRM, is a vanR variant found in the vanM gene cluster. PMID:20733041 vanR_in_vanM_cl Also known as vanRN, is a vanR variant found in the vanN gene cluster. vanR-N vanRN vanR_in_vanN_cl antibiotic_resistance ARO:3002929 vanR gene in vanN cluster ARO:3002929 Also known as vanRN, is a vanR variant found in the vanN gene cluster. PMID:21807981 vanR_in_vanN_cl Also known as vanRO, is a vanR variant found in the vanO gene cluster. vanR-O vanRO vanR_in_vanO_cl antibiotic_resistance ARO:3002930 vanR gene in vanO cluster ARO:3002930 Also known as vanRO, is a vanR variant found in the vanO gene cluster. PMID:24342631 vanR_in_vanO_cl Also known as vanSA, is a vanS variant found in the vanA gene cluster. vanS-A vanSA vanS_in_vanA_cl antibiotic_resistance ARO:3002931 vanS gene in vanA cluster ARO:3002931 Also known as vanSA, is a vanS variant found in the vanA gene cluster. PMID:16323116 PMID:28511809 PMID:8380148 vanS_in_vanA_cl Also known as vanSB, is a vanS variant found in the vanB gene cluster. vanS-B vanSB vanS_in_vanB_cl antibiotic_resistance ARO:3002932 vanS gene in vanB cluster ARO:3002932 Also known as vanSB, is a vanS variant found in the vanB gene cluster. PMID:16323116 PMID:8631706 vanS_in_vanB_cl Also known as vanSC, is a vanS variant found in the vanC gene cluster. vanS-C vanSC vanS_in_vanC_cl antibiotic_resistance ARO:3002933 vanS gene in vanC cluster ARO:3002933 Also known as vanSC, is a vanS variant found in the vanC gene cluster. PMID:10817725 PMID:16323116 vanS_in_vanC_cl Also known as vanSD, is a mutated vanS variant found in the vanD gene cluster that caused constitutive expression of vanD peptidoglycan synthesis. vanS-D vanSD vanS_in_vanD_cl antibiotic_resistance ARO:3002934 vanS gene in vanD cluster ARO:3002934 Also known as vanSD, is a mutated vanS variant found in the vanD gene cluster that caused constitutive expression of vanD peptidoglycan synthesis. PMID:16323116 PMID:19258279 vanS_in_vanD_cl Also known as vanSE, is a vanS variant found in the vanE gene cluster. vanS-E vanSE vanS_in_vanE_cl antibiotic_resistance ARO:3002935 vanS gene in vanE cluster ARO:3002935 Also known as vanSE, is a vanS variant found in the vanE gene cluster. PMID:12019119 vanS_in_vanE_cl Also known as vanSF, is a vanS variant found in the vanF gene cluster. vanS-F vanSF vanS_in_vanF_cl antibiotic_resistance ARO:3002936 vanS gene in vanF cluster ARO:3002936 Also known as vanSF, is a vanS variant found in the vanF gene cluster. PMID:15980329 vanS_in_vanF_cl Also known as vanSG, is a vanS variant found in the vanG gene cluster. vanS-G vanSG vanS_in_vanG_cl antibiotic_resistance ARO:3002937 vanS gene in vanG cluster ARO:3002937 Also known as vanSG, is a vanS variant found in the vanG gene cluster. PMID:16723588 vanS_in_vanG_cl Also known as vanSL, is a vanS variant found in the vanL gene cluster. vanS-L vanSL vanS_in_vanL_cl antibiotic_resistance ARO:3002938 vanS gene in vanL cluster ARO:3002938 Also known as vanSL, is a vanS variant found in the vanL gene cluster. PMID:18458129 vanS_in_vanL_cl Also known as vanSM, is a vanS variant found in the vanM gene cluster. vanS-M vanSM vanS_in_vanM_cl antibiotic_resistance ARO:3002939 vanS gene in vanM cluster ARO:3002939 Also known as vanSM, is a vanS variant found in the vanM gene cluster. PMID:20733041 vanS_in_vanM_cl Also known as vanSN, is a vanS variant found in the vanN gene cluster. vanS-N vanSN vanS_in_vanN_cl antibiotic_resistance ARO:3002940 vanS gene in vanN cluster ARO:3002940 Also known as vanSN, is a vanS variant found in the vanN gene cluster. PMID:21807981 vanS_in_vanN_cl Also known as vanSO, is a vanS variant found in the vanO gene cluster. vanS-O vanSO vanS_in_vanO_cl antibiotic_resistance ARO:3002941 vanS gene in vanO cluster ARO:3002941 Also known as vanSO, is a vanS variant found in the vanO gene cluster. PMID:24342631 vanS_in_vanO_cl Also known as vanHA, is a vanH variant in the vanA gene cluster. vanH-A vanHA vanH_in_vanA_cl antibiotic_resistance ARO:3002942 vanH gene in vanA cluster ARO:3002942 Also known as vanHA, is a vanH variant in the vanA gene cluster. PMID:16323116 PMID:8380148 vanH_in_vanA_cl Also known as vanHB, is a vanH variant in the vanB gene cluster. vanH-B vanHB vanH_in_vanB_cl antibiotic_resistance ARO:3002943 vanH gene in vanB cluster ARO:3002943 Also known as vanHB, is a vanH variant in the vanB gene cluster. PMID:16323116 PMID:8631706 vanH_in_vanB_cl Also known as vanHD, is a vanH variant in the vanD gene cluster. vanH-D vanHD vanH_in_vanD_cl antibiotic_resistance ARO:3002944 vanH gene in vanD cluster ARO:3002944 Also known as vanHD, is a vanH variant in the vanD gene cluster. PMID:12499162 PMID:16323116 vanH_in_vanD_cl Also known as vanHF, is a vanH variant in the vanF gene cluster. vanH-F vanHF vanH_in_vanF_cl antibiotic_resistance ARO:3002945 vanH gene in vanF cluster ARO:3002945 Also known as vanHF, is a vanH variant in the vanF gene cluster. PMID:15980329 vanH_in_vanF_cl Also known as vanHM, is a vanH variant in the vanM gene cluster. vanH-M vanHM vanH_in_vanM_cl antibiotic_resistance ARO:3002947 vanH gene in vanM cluster ARO:3002947 Also known as vanHM, is a vanH variant in the vanM gene cluster. PMID:20733041 vanH_in_vanM_cl Also known as vanHO, is a vanH variant in the vanO gene cluster. vanH-O vanHO vanH_in_vanO_cl antibiotic_resistance ARO:3002948 vanH gene in vanO cluster ARO:3002948 Also known as vanHO, is a vanH variant in the vanO gene cluster. PMID:24342631 vanH_in_vanO_cl Also known as vanXA, is a vanX variant found in the vanA gene cluster. vanX-A vanXA vanX_in_vanA_cl antibiotic_resistance ARO:3002949 vanX gene in vanA cluster ARO:3002949 Also known as vanXA, is a vanX variant found in the vanA gene cluster. PMID:16323116 PMID:8380148 vanX_in_vanA_cl Also known as vanXB, is a vanX variant found in the vanB gene cluster. vanX-B vanXB vanX_in_vanB_cl antibiotic_resistance ARO:3002950 vanX gene in vanB cluster ARO:3002950 Also known as vanXB, is a vanX variant found in the vanB gene cluster. PMID:16323116 PMID:8631706 vanX_in_vanB_cl Also known as vanXF, is a vanX variant found in the vanF gene cluster. vanX-F vanXF vanX_in_vanF_cl antibiotic_resistance ARO:3002952 vanX gene in vanF cluster ARO:3002952 Also known as vanXF, is a vanX variant found in the vanF gene cluster. PMID:15980329 vanX_in_vanF_cl Also known as vanXM, is a vanX variant found in the vanM gene cluster. vanX-M vanXM vanX_in_vanM_cl antibiotic_resistance ARO:3002953 vanX gene in vanM cluster ARO:3002953 Also known as vanXM, is a vanX variant found in the vanM gene cluster. PMID:20733041 vanX_in_vanM_cl Also known as vanXO, is a vanX variant found in the vanO gene cluster. vanX-O vanXO vanX_in_vanO_cl antibiotic_resistance ARO:3002954 vanX gene in vanO cluster ARO:3002954 Also known as vanXO, is a vanX variant found in the vanO gene cluster. PMID:24342631 vanX_in_vanO_cl Also known as vanYA, is a vanY variant found in the vanA gene cluster. vanY-A vanYA vanY_in_vanA_cl antibiotic_resistance ARO:3002955 vanY gene in vanA cluster ARO:3002955 Also known as vanYA, is a vanY variant found in the vanA gene cluster. PMID:16323116 PMID:8380148 vanY_in_vanA_cl Also known as vanYB, is a vanY variant found in the vanB gene cluster. vanY-B vanYB vanY_in_vanB_cl antibiotic_resistance ARO:3002956 vanY gene in vanB cluster ARO:3002956 Also known as vanYB, is a vanY variant found in the vanB gene cluster. PMID:16323116 PMID:8631706 vanY_in_vanB_cl Also known as vanYD, is a vanY variant found in the vanD gene cluster. vanY-D vanYD vanY_in_vanD_cl antibiotic_resistance ARO:3002957 vanY gene in vanD cluster ARO:3002957 Also known as vanYD, is a vanY variant found in the vanD gene cluster. PMID:12499162 PMID:16323116 vanY_in_vanD_cl Also known as vanYF, is a vanY variant found in the vanF gene cluster. vanY-F vanYF vanY_in_vanF_cl antibiotic_resistance ARO:3002958 vanY gene in vanF cluster ARO:3002958 Also known as vanYF, is a vanY variant found in the vanF gene cluster. PMID:15980329 vanY_in_vanF_cl Also known as vanYG, is a vanY variant found in the vanG gene cluster. vanY-G vanYG vanYG1 vanY_in_vanG_cl antibiotic_resistance ARO:3002959 vanY gene in vanG cluster ARO:3002959 Also known as vanYG, is a vanY variant found in the vanG gene cluster. PMID:16723588 vanY_in_vanG_cl Also known as vanYM, is a vanY variant found in the vanM gene cluster. vanY-M vanYM vanY_in_vanM_cl antibiotic_resistance ARO:3002961 vanY gene in vanM cluster ARO:3002961 Also known as vanYM, is a vanY variant found in the vanM gene cluster. PMID:20733041 vanY_in_vanM_cl Also known as vanZA, is a vanZ variant found in the vanA gene cluster. vanZ-A vanZA vanZ_in_vanA_cl antibiotic_resistance ARO:3002962 vanZ gene in vanA cluster ARO:3002962 Also known as vanZA, is a vanZ variant found in the vanA gene cluster. PMID:16323116 PMID:7867956 PMID:8380148 vanZ_in_vanA_cl Also known as vanZF, is a vanZ variant found in the vanF gene cluster. vanZ-F vanZF vanZ_in_vanF_cl antibiotic_resistance ARO:3002963 vanZ gene in vanF cluster ARO:3002963 Also known as vanZF, is a vanZ variant found in the vanF gene cluster. PMID:15980329 vanZ_in_vanF_cl Also known as vanWB, is a vanW variant found in the vanB gene cluster. vanW-B vanWB vanW_in_vanB_cl antibiotic_resistance ARO:3002964 vanW gene in vanB cluster ARO:3002964 Also known as vanWB, is a vanW variant found in the vanB gene cluster. PMID:16323116 PMID:8631706 vanW_in_vanB_cl Also known as vanWG, is a vanW variant found in the vanG gene cluster. vanW-G vanWG vanW_in_vanG_cl antibiotic_resistance ARO:3002965 vanW gene in vanG cluster ARO:3002965 Also known as vanWG, is a vanW variant found in the vanG gene cluster. PMID:16723588 vanW_in_vanG_cl Also known as vanXYC, is a vanXY variant found in the vanC gene cluster. vanXY-C vanXYC vanXY_in_vanC antibiotic_resistance ARO:3002966 vanXY gene in vanC cluster ARO:3002966 Also known as vanXYC, is a vanXY variant found in the vanC gene cluster. PMID:10564477 PMID:16323116 vanXY_in_vanC Also known as vanXY, is a vanXY variant found in the vanE gene cluster. vanXY-E vanXYE vanXY_in_vanE antibiotic_resistance ARO:3002967 vanXY gene in vanE cluster ARO:3002967 Also known as vanXY, is a vanXY variant found in the vanE gene cluster. PMID:12019119 vanXY_in_vanE Also known as vanXYL, is a vanXY variant found in the vanL gene cluster. vanXY-L vanXYL vanXY_in_vanL antibiotic_resistance ARO:3002968 vanXY gene in vanL cluster ARO:3002968 Also known as vanXYL, is a vanXY variant found in the vanL gene cluster. PMID:18458129 vanXY_in_vanL Also known as vanXYN, is a vanXY variant found in the vanN gene cluster. vanXY-N vanXYN vanXY_in_vanN antibiotic_resistance ARO:3002969 vanXY gene in vanN cluster ARO:3002969 Also known as vanXYN, is a vanXY variant found in the vanN gene cluster. PMID:21807981 vanXY_in_vanN Also known as vanTC, is a vanT variant found in the vanC gene cluster. vanT-C vanTC vanT_in_vanC_cl antibiotic_resistance ARO:3002970 vanT gene in vanC cluster ARO:3002970 Also known as vanTC, is a vanT variant found in the vanC gene cluster. PMID:10209740 PMID:16323116 vanT_in_vanC_cl Also known as vanTE, is a vanT variant found in the vanE gene cluster. vanT-E vanTE vanT_in_vanE_cl antibiotic_resistance ARO:3002971 vanT gene in vanE cluster ARO:3002971 Also known as vanTE, is a vanT variant found in the vanE gene cluster. PMID:12019119 vanT_in_vanE_cl Also known as vanTG, is a vanT variant found in the vanG gene cluster. vanT-G vanTG vanT_in_vanG_cl antibiotic_resistance ARO:3002972 vanT gene in vanG cluster ARO:3002972 Also known as vanTG, is a vanT variant found in the vanG gene cluster. PMID:16723588 vanT_in_vanG_cl Also known as vanTmL, is a vanT variant found in the vanL gene cluster. vanTmL codes for the membrane-binding domain of vanTL. vanTm-L vanTmL vanTm_in_vanL antibiotic_resistance ARO:3002973 vanTm gene in vanL cluster ARO:3002973 Also known as vanTmL, is a vanT variant found in the vanL gene cluster. vanTmL codes for the membrane-binding domain of vanTL. PMID:18458129 vanTm_in_vanL Also known as vanTrL, is a vanT variant found in the vanL gene cluster. vanTrL codes for the racemase component of vanT. vanTr-L vanTrL vanTr_in_vanL antibiotic_resistance ARO:3002974 vanTr gene in vanL cluster ARO:3002974 Also known as vanTrL, is a vanT variant found in the vanL gene cluster. vanTrL codes for the racemase component of vanT. PMID:18458129 vanTr_in_vanL Also known as vanTN, is a vanT variant found in the vanN gene cluster. vanT-N vanTN vanT_in_vanN_cl antibiotic_resistance ARO:3002975 vanT gene in vanN cluster ARO:3002975 Also known as vanTN, is a vanT variant found in the vanN gene cluster. PMID:21807981 vanT_in_vanN_cl Van genes encode for various proteins that are involved in conferring vancomycin and teicoplanin resistance. antibiotic_resistance ARO:3002976 gene(s) or protein(s) associated with a glycopeptide resistance cluster ARO:3002976 A van ligase that synthesizes D-Ala-D-Lac, an alternative peptidoglycan substrate that confers resistance to vancomycin. antibiotic_resistance ARO:3002978 D-Ala-D-Lac ligase ARO:3002978 A van ligase that synthesizes D-Ala-D-Lac, an alternative peptidoglycan substrate that confers resistance to vancomycin. PMID:15980329 PMID:16323116 PMID:20733041 PMID:24342631 A van ligase that synthesizes D-Ala-D-Ser, an alternative peptidoglycan substrate that confers resistance to vancomycin. antibiotic_resistance ARO:3002979 D-Ala-D-Ser ligase ARO:3002979 A van ligase that synthesizes D-Ala-D-Ser, an alternative peptidoglycan substrate that confers resistance to vancomycin. PMID:12019119 PMID:16323116 PMID:16723588 PMID:18458129 PMID:21807981 PMID:22969085 Aspergillomarasmine A, a fungal natural product, has been shown to inhibit the NDM-1 and VIM-2 enzymes, restoring of the activity of meropenem against carbapenem-resistant pathogens possessing either NDM-1 or VIM-2. ChEBI:180884 ChEMBL:CHEMBL4087144 PubChem:197028 BRN 2422056 Toxin C antibiotic_resistance ARO:3002980 aspergillomarasmine A ARO:3002980 Aspergillomarasmine A, a fungal natural product, has been shown to inhibit the NDM-1 and VIM-2 enzymes, restoring of the activity of meropenem against carbapenem-resistant pathogens possessing either NDM-1 or VIM-2. PMID:24965651 PMID:35155911 AmrAB is an RND efflux system that impairs aminoglycoside accumulation in clinical Burkholderia vietnamiensis strains. antibiotic_resistance ARO:3002981 AmrAB-OprM ARO:3002981 AmrAB is an RND efflux system that impairs aminoglycoside accumulation in clinical Burkholderia vietnamiensis strains. PMID:10582892 PMID:24393536 amrA is the efflux pump subunit of the AmrAB-OprM multidrug efflux complex. amrA corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. amrA antibiotic_resistance ARO:3002982 amrA ARO:3002982 amrA is the efflux pump subunit of the AmrAB-OprM multidrug efflux complex. amrA corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. PMID:10582892 PMID:24393536 amrA amrB is the membrane fusion protein of the AmrAB-OprM multidrug efflux complex. amrB antibiotic_resistance ARO:3002983 amrB ARO:3002983 amrB is the membrane fusion protein of the AmrAB-OprM multidrug efflux complex. PMID:10582892 PMID:24393536 amrB arnA modifies lipid A with 4-amino-4-deoxy-L-arabinose (Ara4N) which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. arnA is found in E. coli and P. aeruginosa. PmrL arnA antibiotic_resistance ARO:3002985 arnA ARO:3002985 arnA modifies lipid A with 4-amino-4-deoxy-L-arabinose (Ara4N) which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. arnA is found in E. coli and P. aeruginosa. PMID:11021929 PMID:15939024 arnA The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin. bacA antibiotic_resistance ARO:3002986 bacA ARO:3002986 The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin. PMID:23460607 bacA bcrA is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance. bcrA antibiotic_resistance ARO:3002987 bcrA ARO:3002987 bcrA is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance. PMID:7476193 bcrA bcrB is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance. bcrB antibiotic_resistance ARO:3002988 bcrB ARO:3002988 bcrB is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance. PMID:7476193 bcrB AQU beta-lactamases are chromosomal class C beta-lactamases that confer resistance to cephalosporins. antibiotic_resistance ARO:3002992 AQU beta-lactamase ARO:3002992 AQU beta-lactamases are chromosomal class C beta-lactamases that confer resistance to cephalosporins. PMID:24055254 AQU-1 is a chromosomal class C beta-lactamase found in clinical Aeromonas dhakensis isolates. AQU-1 antibiotic_resistance ARO:3002993 AQU-1 ARO:3002993 AQU-1 is a chromosomal class C beta-lactamase found in clinical Aeromonas dhakensis isolates. PMID:24055254 AQU-1 ROB beta-lactamases are a class A beta-lactamases. antibiotic_resistance ARO:3002994 ROB beta-lactamase ARO:3002994 ROB beta-lactamases are a class A beta-lactamases. PMID:2201253 ROB-1 is a beta-lactamase found in Pasteurella and Haemophilus. ROB-1 antibiotic_resistance ARO:3002995 ROB-1 ARO:3002995 ROB-1 is a beta-lactamase found in Pasteurella and Haemophilus. PMID:17438055 PMID:2024956 ROB-1 LCR beta-lactamases are a class D beta-lactamase that hydrolyze a variety of penams and some cephalosporins. antibiotic_resistance ARO:3002996 LCR beta-lactamase ARO:3002996 LCR-1 is a class D beta-lactamase found in Pseudomonas aeruginosa. LCR-1 antibiotic_resistance ARO:3002997 LCR-1 ARO:3002997 LCR-1 is a class D beta-lactamase found in Pseudomonas aeruginosa. PMID:1495394 LCR-1 CblA beta-lactamases are class A beta-lactamases that confer resistance to cephalosporins. antibiotic_resistance ARO:3002998 CblA beta-lactamase ARO:3002998 CblA beta-lactamases are class A beta-lactamases that confer resistance to cephalosporins. PMID:7985999 CblA-1 beta-lactamase is a class A beta-lactamase found in Bacteroides uniformis that is species-specific. CblA-1 antibiotic_resistance ARO:3002999 CblA-1 ARO:3002999 CblA-1 beta-lactamase is a class A beta-lactamase found in Bacteroides uniformis that is species-specific. PMID:7985999 CblA-1 CfxA beta-lactamases are class A beta-lactamases. antibiotic_resistance ARO:3003000 CfxA beta-lactamase ARO:3003000 CfxA beta-lactamases are class A beta-lactamases. PMID:8517690 CfxA beta-lactamase is a class A beta-lactamase found in Bacteroides vulgatus. CfxA antibiotic_resistance ARO:3003001 CfxA ARO:3003001 CfxA beta-lactamase is a class A beta-lactamase found in Bacteroides vulgatus. PMID:8517690 CfxA CfxA2 beta-lactamase is a class A beta-lactamase found in Prevotella intermedia. CfxA2 antibiotic_resistance ARO:3003002 CfxA2 ARO:3003002 CfxA2 beta-lactamase is a class A beta-lactamase found in Prevotella intermedia. PMID:11451705 CfxA2 CfxA3 beta-lactamase is a class A beta-lactamase found in Capnocytophaga ochracea. CfxA3 antibiotic_resistance ARO:3003003 CfxA3 ARO:3003003 CfxA3 beta-lactamase is a class A beta-lactamase found in Capnocytophaga ochracea. PMID:14766881 CfxA3 cfxA4 beta-lactamase is a class A beta-lactamase found in Bacteroides fragilis. CfxA4 antibiotic_resistance ARO:3003005 CfxA4 ARO:3003005 cfxA4 beta-lactamase is a class A beta-lactamase found in Bacteroides fragilis. PMID:25460195 CfxA4 blt is an MFS efflux pump that confers resistance to multiple drugs such as rhodamine and acridine dyes, and fluoroquinolone antibiotics. blt antibiotic_resistance ARO:3003006 blt ARO:3003006 blt is an MFS efflux pump that confers resistance to multiple drugs such as rhodamine and acridine dyes, and fluoroquinolone antibiotics. PMID:7608059 blt bmr is an MFS antibiotic efflux pump that confers resistance to multiple drugs including acridine dyes, fluoroquinolone antibiotics, chloramphenicol, and puromycin. bmr antibiotic_resistance ARO:3003007 bmr ARO:3003007 bmr is an MFS antibiotic efflux pump that confers resistance to multiple drugs including acridine dyes, fluoroquinolone antibiotics, chloramphenicol, and puromycin. PMID:1675788 PMID:9079903 bmr CeoAB is an RND efflux system that confers multidrug resistance in Burkholderia cenocepacia. antibiotic_resistance ARO:3003008 CeoAB-OpcM ARO:3003008 CeoAB is an RND efflux system that confers multidrug resistance in Burkholderia cenocepacia. PMID:16857052 ceoA is a periplasmic linker subunit of the CeoAB-OpcM efflux pump. ceoA antibiotic_resistance ARO:3003009 ceoA ARO:3003009 ceoA is a periplasmic linker subunit of the CeoAB-OpcM efflux pump. PMID:16857052 ceoA ceoB is a cytoplasmic membrane component of the CeoAB-OpcM efflux pump. ceoB antibiotic_resistance ARO:3003010 ceoB ARO:3003010 ceoB is a cytoplasmic membrane component of the CeoAB-OpcM efflux pump. PMID:16857052 ceoB dfrA10 is an integron-encoded dihydrofolate reductase found in Klebsiella pneumoniae. dfrA10 antibiotic_resistance ARO:3003011 dfrA10 ARO:3003011 dfrA10 is an integron-encoded dihydrofolate reductase found in Klebsiella pneumoniae. PMID:12499211 dfrA10 dfrA13 is an integron-encoded dihydrofolate reductase found in Escherichia coli. dfrA13 antibiotic_resistance ARO:3003012 dfrA13 ARO:3003012 dfrA13 is an integron-encoded dihydrofolate reductase found in Escherichia coli. PMID:15140390 PMID:20374640 PMID:21237262 dfrA13 dfrA15 is an integron-encoded dihydrofolate reductase found in Vibrio cholerae. dfrA15 antibiotic_resistance ARO:3003013 dfrA15 ARO:3003013 dfrA15 is an integron-encoded dihydrofolate reductase found in Vibrio cholerae. PMID:16980697 dfrA15 dfrA16 is an integron-encoded dihydrofolate reductase found in Salmonella enterica. dfrA16 antibiotic_resistance ARO:3003014 dfrA16 ARO:3003014 dfrA16 is an integron-encoded dihydrofolate reductase found in Salmonella enterica. PMID:17233727 dfrA16 dfrA19 is an integron-encoded dihydrofolate reductase found in Klebsiella pneumoniae. dfrA19 antibiotic_resistance ARO:3003015 dfrA19 ARO:3003015 dfrA19 is an integron-encoded dihydrofolate reductase found in Klebsiella pneumoniae. PMID:17368003 dfrA19 dfrA20 is a plasmid-encoded dihydrofolate reductase found in Pasteurella multocida. dfrA20 antibiotic_resistance ARO:3003016 dfrA20 ARO:3003016 dfrA20 is a plasmid-encoded dihydrofolate reductase found in Pasteurella multocida. PMID:15616323 dfrA20 dfrA21 is an integron-encoded dihydrofolate reductase found in Salmonella enterica. dfrA21 antibiotic_resistance ARO:3003017 dfrA21 ARO:3003017 dfrA21 is an integron-encoded dihydrofolate reductase found in Salmonella enterica. PMID:15750057 dfrA21 dfrA22 is an integron-encoded dihydrofolate reductase found in Salmonella enterica. dfrA22 antibiotic_resistance ARO:3003018 dfrA22 ARO:3003018 dfrA22 is an integron-encoded dihydrofolate reductase found in Salmonella enterica. PMID:16782743 PMID:24152716 dfrA22 dfrA23 is an integron-encoded dihydrofolate reductase found in Salmonella enterica. dfrA23 antibiotic_resistance ARO:3003019 dfrA23 ARO:3003019 dfrA23 is an integron-encoded dihydrofolate reductase found in Salmonella enterica. PMID:15728925 dfrA23 dfrA25 is an integron-encoded dihydrofolate reductase found in Salmonella agona. dfrA25 antibiotic_resistance ARO:3003020 dfrA25 ARO:3003020 dfrA25 is an integron-encoded dihydrofolate reductase found in Salmonella agona. PMID:16980698 dfrA25 dfrB2 is an integron-encoded dihydrofolate reductase found in an uncultured bacterium from a wastewater treatment plant. dfrB2 antibiotic_resistance ARO:3003021 dfrB2 ARO:3003021 dfrB2 is an integron-encoded dihydrofolate reductase found in an uncultured bacterium from a wastewater treatment plant. PMID:17261525 PMID:19719593 dfrB2 dfrB3 is an integron-encoded dihydrofolate reductase found in Klebsiella oxytoca. dfrB3 antibiotic_resistance ARO:3003022 dfrB3 ARO:3003022 dfrB3 is an integron-encoded dihydrofolate reductase found in Klebsiella oxytoca. PMID:22507248 dfrB3 dfrB6 is an integron-encoded dihydrofolate reductase found in Salmonella enterica. dfrB6 antibiotic_resistance ARO:3003023 dfrB6 ARO:3003023 dfrB6 is an integron-encoded dihydrofolate reductase found in Salmonella enterica. PMID:16870788 dfrB6 Enzymes that confer resistance to fusidic acid by inactivation. antibiotic_resistance ARO:3003025 fusidic acid inactivation enzyme ARO:3003025 fusH is a highly specific fusidic acid esterase found in Streptomyces lividans. fusH antibiotic_resistance ARO:3003026 fusH ARO:3003026 fusH is a highly specific fusidic acid esterase found in Streptomyces lividans. PMID:9084170 fusH lmrAB operon is involved in lincosamide resistance in Bacillus subtilis. antibiotic_resistance ARO:3003027 lmrAB Operon ARO:3003027 lmrAB operon is involved in lincosamide resistance in Bacillus subtilis. PMID:15317768 lmrA is the repressor to the lmrAB operon in Bacillus subtilis. lmrA mutations result in lincomycin resistance. lmrA antibiotic_resistance ARO:3003028 lmrA ARO:3003028 lmrA is the repressor to the lmrAB operon in Bacillus subtilis. lmrA mutations result in lincomycin resistance. PMID:15317768 PMID:9384377 lmrA MexVW-OprM is a multidrug efflux protein expressed in Pseudomonas aeruginosa. MexV is the membrane fusion protein; MexW is the RND-type membrane protein; and OprM is the outer membrane channel. MexVW-OprM is associated with resistance to fluoroquinolones, tetracycline, chloramphenicol, erythromycin and acriflavine. MexVW-OprM antibiotic_resistance ARO:3003029 MexVW-OprM ARO:3003029 MexVW-OprM is a multidrug efflux protein expressed in Pseudomonas aeruginosa. MexV is the membrane fusion protein; MexW is the RND-type membrane protein; and OprM is the outer membrane channel. MexVW-OprM is associated with resistance to fluoroquinolones, tetracycline, chloramphenicol, erythromycin and acriflavine. PMID:12951344 MexVW-OprM MexV is the membrane fusion protein of the MexVW-OprM multidrug efflux complex. MexV antibiotic_resistance ARO:3003030 MexV ARO:3003030 MexV is the membrane fusion protein of the MexVW-OprM multidrug efflux complex. PMID:12951344 MexV MexW is the RND-type membrane protein of the efflux complex MexVW-OprM. MexW antibiotic_resistance ARO:3003031 MexW ARO:3003031 MexW is the RND-type membrane protein of the efflux complex MexVW-OprM. PMID:12951344 MexW MexXY-OprM is a multidrug efflux protein expressed in Pseudomonas aeruginosa. MexY is the membrane fusion protein; MexX is the RND-type membrane protein; and OprM is the outer membrane channel. MexXY-OprM is associated with resistance to acriflavine, erythromycin, norfloxacin and ofloxacin. The efflux system may also be involved in acquisition of higher resistance, in particular when bacteria are repeatedly exposed to subinhibitory doses of AGs. MexXY-OprM antibiotic_resistance ARO:3003032 MexXY-OprM ARO:3003032 MexXY-OprM is a multidrug efflux protein expressed in Pseudomonas aeruginosa. MexY is the membrane fusion protein; MexX is the RND-type membrane protein; and OprM is the outer membrane channel. MexXY-OprM is associated with resistance to acriflavine, erythromycin, norfloxacin and ofloxacin. The efflux system may also be involved in acquisition of higher resistance, in particular when bacteria are repeatedly exposed to subinhibitory doses of AGs. PMID:12654672 PMID:21149619 PMID:23233851 PMID:9925549 MexXY-OprM MexY is the RND-type membrane protein of the efflux complex MexXY-OprM. mexY antibiotic_resistance ARO:3003033 mexY ARO:3003033 MexY is the RND-type membrane protein of the efflux complex MexXY-OprM. PMID:9925549 mexY MexX is the membrane fusion protein of the MexXY-OprM multidrug efflux complex. mexX antibiotic_resistance ARO:3003034 mexX ARO:3003034 MexX is the membrane fusion protein of the MexXY-OprM multidrug efflux complex. PMID:9925549 mexX mfpA is a qnr homolog and a pentapeptide repeat protein that confers resistance to fluoroquinolones in Mycolicibacterium smegmatis. PDB:2BM7 mfpA antibiotic_resistance ARO:3003035 mfpA ARO:3003035 mfpA is a qnr homolog and a pentapeptide repeat protein that confers resistance to fluoroquinolones in Mycolicibacterium smegmatis. PMID:15933203 mfpA oleB is an ABC-F subfamily protein in Streptomyces antibioticus and is involved in oleandomycin secretion. oleB antibiotic_resistance ARO:3003036 oleB ARO:3003036 oleB is an ABC-F subfamily protein in Streptomyces antibioticus and is involved in oleandomycin secretion. PMID:9003412 oleB OpcM is an outer membrane factor protein found in Burkholderia cepacia. It is part of the CeoAB-OpcM complex. opcM antibiotic_resistance ARO:3003037 opcM ARO:3003037 OpcM is an outer membrane factor protein found in Burkholderia cepacia. It is part of the CeoAB-OpcM complex. PMID:8834871 opcM MexXY-OprA is a multidrug efflux protein expressed in Pseudomonas aeruginosa. MexY is the membrane fusion protein; MexX is the RND-type membrane protein; and OprA is the outer membrane channel. MexXY-OprA is associated with resistance to aminoglycosides. MexXY-OprA antibiotic_resistance ARO:3003038 MexXY-OprA ARO:3003038 MexXY-OprA is a multidrug efflux protein expressed in Pseudomonas aeruginosa. MexY is the membrane fusion protein; MexX is the RND-type membrane protein; and OprA is the outer membrane channel. MexXY-OprA is associated with resistance to aminoglycosides. PMID:22282519 MexXY-OprA OprA is an outer membrane factor protein found in Pseudomonas aeruginosa. It is part of the MexXY-OprA complex. OprA antibiotic_resistance ARO:3003039 OprA ARO:3003039 OprA is an outer membrane factor protein found in Pseudomonas aeruginosa. It is part of the MexXY-OprA complex. PMID:22282519 OprA Pencillin-binding proteins are transpeptidase proteins essential for cell wall synthesis. PBPs bind to penicillin antibiotics, which inactivates the enzyme and therefore disrupts cell wall synthesis. Multiple mechanisms and determinants are implicated in antibiotic resistant PBP. antibiotic_resistance ARO:3003040 beta-lactam resistant penicillin-binding proteins ARO:3003040 PBP1a is a penicillin-binding protein found in Streptococcus pneumoniae. Spne_PBP1a_AMX antibiotic_resistance ARO:3003041 Streptococcus pneumoniae PBP1a conferring resistance to amoxicillin ARO:3003041 PBP1a is a penicillin-binding protein found in Streptococcus pneumoniae. PMID:18394970 Spne_PBP1a_AMX PBP2b is a penicillin-binding protein found in Streptococcus pneumoniae. Spne_PBP2b_AMX antibiotic_resistance ARO:3003042 Streptococcus pneumoniae PBP2b conferring resistance to amoxicillin ARO:3003042 PBP2b is a penicillin-binding protein found in Streptococcus pneumoniae. PMID:18394970 Spne_PBP2b_AMX PBP2x is a penicillin-binding protein found in Streptococcus pneumoniae. Spne_PBP2x_AMX antibiotic_resistance ARO:3003043 Streptococcus pneumoniae PBP2x conferring resistance to amoxicillin ARO:3003043 PBP2x is a penicillin-binding protein found in Streptococcus pneumoniae. PMID:18394970 Spne_PBP2x_AMX qacA is a subunit of the qac multidrug efflux pump. qacA antibiotic_resistance ARO:3003046 qacA ARO:3003046 qacA is a subunit of the qac multidrug efflux pump. PMID:12820795 qacA qacB is a subunit of the qac multidrug efflux pump. qacB antibiotic_resistance ARO:3003047 qacB ARO:3003047 qacB is a subunit of the qac multidrug efflux pump. PMID:12820795 qacB rosA is part of an efflux pump/potassium antiporter system (RosAB) in Yersinia that confers resistance to cationic antimicrobial peptides such as polymyxin B. rosA antibiotic_resistance ARO:3003048 rosA ARO:3003048 rosA is part of an efflux pump/potassium antiporter system (RosAB) in Yersinia that confers resistance to cationic antimicrobial peptides such as polymyxin B. PMID:10931306 rosA rosB is part of an efflux pump/potassium antiporter system (RosAB) in Yersinia that confers resistance to cationic antimicrobial peptides such as polymyxin B. rosB antibiotic_resistance ARO:3003049 rosB ARO:3003049 rosB is part of an efflux pump/potassium antiporter system (RosAB) in Yersinia that confers resistance to cationic antimicrobial peptides such as polymyxin B. PMID:10931306 rosB SmeABC is a multidrug resistance efflux pump that confers resistance to aminoglycosides, beta-lactams, and fluoroquinolones in Stenotrophomonas maltophilia. antibiotic_resistance ARO:3003050 SmeABC ARO:3003050 SmeABC is a multidrug resistance efflux pump that confers resistance to aminoglycosides, beta-lactams, and fluoroquinolones in Stenotrophomonas maltophilia. PMID:11796339 smeA is the membrane fusion protein of the smeABC multidrug efflux complex in Stenotrophomonas maltophilia. smeA antibiotic_resistance ARO:3003051 smeA ARO:3003051 smeA is the membrane fusion protein of the smeABC multidrug efflux complex in Stenotrophomonas maltophilia. PMID:11796339 smeA smeB is the inner membrane multidrug exporter of the efflux complex smeABC in Stenotrophomonas maltophilia. smeB antibiotic_resistance ARO:3003052 smeB ARO:3003052 smeB is the inner membrane multidrug exporter of the efflux complex smeABC in Stenotrophomonas maltophilia. PMID:11796339 smeB smeC is an outer membrane multidrug efflux protein of the smeABC complex in Stenotrophomonas maltophilia. smeC antibiotic_resistance ARO:3003053 smeC ARO:3003053 smeC is an outer membrane multidrug efflux protein of the smeABC complex in Stenotrophomonas maltophilia. PMID:11796339 smeC SmeDEF is a multidrug resistance efflux pump that confers resistance to quinolones, tetracyclines, macrolides, chloramphenicol, and novobiocin in Stenotrophomonas maltophilia. antibiotic_resistance ARO:3003054 SmeDEF ARO:3003054 SmeDEF is a multidrug resistance efflux pump that confers resistance to quinolones, tetracyclines, macrolides, chloramphenicol, and novobiocin in Stenotrophomonas maltophilia. PMID:11709330 smeD is the membrane fusion protein of the smeDEF multidrug efflux complex in Stenotrophomonas maltophilia. smeD antibiotic_resistance ARO:3003055 smeD ARO:3003055 smeD is the membrane fusion protein of the smeDEF multidrug efflux complex in Stenotrophomonas maltophilia. PMID:11709330 smeD smeE is the RND protein of the efflux complex smeDEF in Stenotrophomonas maltophilia. smeE antibiotic_resistance ARO:3003056 smeE ARO:3003056 smeE is the RND protein of the efflux complex smeDEF in Stenotrophomonas maltophilia. PMID:11709330 smeE smeF is an outer membrane multidrug efflux protein of the smeDEF complex in Stenotrophomonas maltophilia. smeF antibiotic_resistance ARO:3003057 smeF ARO:3003057 smeF is an outer membrane multidrug efflux protein of the smeDEF complex in Stenotrophomonas maltophilia. PMID:11709330 smeF tmrB is an ATP-binding tunicamycin resistance protein found in Bacillus subtilis. tmrB antibiotic_resistance ARO:3003059 tmrB ARO:3003059 tmrB is an ATP-binding tunicamycin resistance protein found in Bacillus subtilis. PMID:7766032 tmrB tsnR is a 23S ribosomal RNA methyltransferase that methylates adenosine-1067 to confer resistance to thiostrepton. tsnR antibiotic_resistance ARO:3003060 tsnR ARO:3003060 tsnR is a 23S ribosomal RNA methyltransferase that methylates adenosine-1067 to confer resistance to thiostrepton. PMID:7590303 tsnR vph is a phosphotransferase that confers resistance to viomycin in Streptomyces vinaceus. vph antibiotic_resistance ARO:3003061 vph ARO:3003061 vph is a phosphotransferase that confers resistance to viomycin in Streptomyces vinaceus. PMID:2987648 vph ykkCD is a multidrug efflux pump with two SMR-type protein subunits that confers resistance to cationic drugs, chloramphenicol, streptomycin and tetracycline. antibiotic_resistance ARO:3003062 ykkCD ARO:3003062 ykkCD is a multidrug efflux pump with two SMR-type protein subunits that confers resistance to cationic drugs, chloramphenicol, streptomycin and tetracycline. PMID:10735877 ykkC is an SMR-type protein that is a subunit of the ykkCD efflux pump. ykkC antibiotic_resistance ARO:3003063 ykkC ARO:3003063 ykkC is an SMR-type protein that is a subunit of the ykkCD efflux pump. PMID:10735877 ykkC ykkD is an SMR-type protein that is a subunit of the ykkCD efflux pump. ykkD antibiotic_resistance ARO:3003064 ykkD ARO:3003064 ykkD is an SMR-type protein that is a subunit of the ykkCD efflux pump. PMID:10735877 ykkD Non-erm 23S ribosomal RNA methyltransferases modify adenosine 1067 to confer resistance to peptide antibiotics. antibiotic_resistance ARO:3003065 non-erm 23S ribosomal RNA methyltransferase (A1067) ARO:3003065 smeR is the responder component of a two component signal transduction system that includes smeS. smeR antibiotic_resistance ARO:3003066 smeR ARO:3003066 smeR is the responder component of a two component signal transduction system that includes smeS. PMID:11796339 smeR smeS is the protein kinase sensor component of a two component signal transduction system that includes smeR. smeS antibiotic_resistance ARO:3003067 smeS ARO:3003067 smeS is the protein kinase sensor component of a two component signal transduction system that includes smeR. PMID:11796339 smeS smeRS is a two component regulatory system for smeABC where smeR is a response regulator, while smeS is a sensor kinase. antibiotic_resistance ARO:3003068 smeRS ARO:3003068 Also known as vanXYG, is a vanXY variant found in the vanG gene cluster. vanXY-G vanXYG vanXY_in_vanG vanYG2 antibiotic_resistance ARO:3003069 vanXY gene in vanG cluster ARO:3003069 Also known as vanXYG, is a vanXY variant found in the vanG gene cluster. PMID:16723588 vanXY_in_vanG Also known as vanXD, is a vanX variant found in the vanD gene cluster. vanX-D vanXD vanX_in_vanD_cl antibiotic_resistance ARO:3003070 vanX gene in vanD cluster ARO:3003070 Also known as vanXD, is a vanX variant found in the vanD gene cluster. PMID:12499162 vanX_in_vanD_cl mphF is a macrolide phosphotransferase and resistance gene identified on the IncP plasmid pRSB111. mphF antibiotic_resistance ARO:3003071 mphF ARO:3003071 mphF is a macrolide phosphotransferase and resistance gene identified on the IncP plasmid pRSB111. PMID:17101677 PMID:29317655 mphF mphL is a chromosomally-encoded macrolide phosphotransferases that inactivate 14- and 15-membered macrolides such as erythromycin, clarithromycin, azithromycin. mphL antibiotic_resistance ARO:3003072 mphL ARO:3003072 mphL is a chromosomally-encoded macrolide phosphotransferases that inactivate 14- and 15-membered macrolides such as erythromycin, clarithromycin, azithromycin. PMID:25059531 PMID:29317655 mphL Cardiolipin synthetase (cls) is an inner membrane protein that is involved in membrane synthesis. Specific mutations in S. aureus can confer resistance to daptomycin. Saur_cls_DAP cls1 cls2 antibiotic_resistance ARO:3003074 Staphylococcus aureus cls conferring resistance to daptomycin ARO:3003074 Cardiolipin synthetase (cls) is an inner membrane protein that is involved in membrane synthesis. Specific mutations in S. aureus can confer resistance to daptomycin. PMID:22238576 Saur_cls_DAP liaFSR is a two-component signal transduction pathway in B. subtilis that responds to peptide and lipopeptide antibiotics. The liaFSR two-component system consists of a histidine kinase liaS and the response regulator liaR as well as the accessory protein liaF, which acts as a negative regulator of liaRS-dependent signal transduction. Mutations confer resistance to daptomycin. antibiotic_resistance ARO:3003076 daptomycin resistant liaFSR ARO:3003076 liaFSR is a two-component signal transduction pathway in B. subtilis that responds to peptide and lipopeptide antibiotics. The liaFSR two-component system consists of a histidine kinase liaS and the response regulator liaR as well as the accessory protein liaF, which acts as a negative regulator of liaRS-dependent signal transduction. Mutations confer resistance to daptomycin. PMID:21899450 liaF is an accessory protein that acts as a negative regulator of liaRS signal transduction pathway. Mutations confer daptomycin resistance. Efae_liaF_DAP antibiotic_resistance ARO:3003077 Enterococcus faecalis liaF mutant conferring daptomycin resistance ARO:3003077 liaF is an accessory protein that acts as a negative regulator of liaRS signal transduction pathway. Mutations confer daptomycin resistance. PMID:21899450 PMID:23959318 Efae_liaF_DAP liaR is a response regulator found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance. Efac_liaR_DAP yvqE antibiotic_resistance ARO:3003078 Enterococcus faecium liaR mutant conferring daptomycin resistance ARO:3003078 liaR is a response regulator found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance. PMID:21899450 Efac_liaR_DAP liaS is a histidine kinase found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance. Efac_liaS_DAP yvqC antibiotic_resistance ARO:3003079 Enterococcus faecium liaS mutant conferring daptomycin resistance ARO:3003079 liaS is a histidine kinase found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance. PMID:21899450 PMID:22664970 Efac_liaS_DAP pgsA or phosphatidylglycerophosphate synthetase is an integral membrane protein involved in phospholipid biosynthesis. It is a CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase. Laboratory experiments have detected mutations conferring daptomycin resistance in Entercoccus. phosphatidylglycerophosphate synthetase antibiotic_resistance ARO:3003080 daptomycin resistant pgsA ARO:3003080 pgsA or phosphatidylglycerophosphate synthetase is an integral membrane protein involved in phospholipid biosynthesis. It is a CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase. Laboratory experiments have detected mutations conferring daptomycin resistance in Entercoccus. PMID:21709092 PMID:22238576 Daptomycin-resistant RNA polymerases include amino acids substitutions which alter expression of the dlt operon, which increases the cell surface positive charge. Known from S. aureus. antibiotic_resistance ARO:3003090 daptomycin-resistant beta-subunit of RNA polymerase (rpoB) ARO:3003090 Daptomycin-resistant RNA polymerases include amino acids substitutions which alter expression of the dlt operon, which increases the cell surface positive charge. Known from S. aureus. PMID:20837752 MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface of both Gram-positive and Gram-negative bacteria. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. Mutations in mprF can additionally confer resistance to daptomycin in S. aureus. antibiotic_resistance ARO:3003091 daptomycin resistant mprF ARO:3003091 MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface of both Gram-positive and Gram-negative bacteria. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. Mutations in mprF can additionally confer resistance to daptomycin in S. aureus. PMID:16723576 PMID:20498310 PMID:22238576 cls or cardiolipin synthetase is an inner membrane protein that is involved in membrane synthesis. Specific mutations in Enterococcus can confer resistance to daptomycin. Efac_cls_DAP cls1 cls2 antibiotic_resistance ARO:3003092 Enterococcus faecium cls conferring resistance to daptomycin ARO:3003092 cls or cardiolipin synthetase is an inner membrane protein that is involved in membrane synthesis. Specific mutations in Enterococcus can confer resistance to daptomycin. PMID:21899450 PMID:22948885 PMID:23114777 PMID:23580562 PMID:26454536 Efac_cls_DAP CEPH-A3 is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas veronii. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein. cphA3 antibiotic_resistance ARO:3003093 cphA3 ARO:3003093 cphA3 imiH is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas hydrophila. This enzyme has specific activity against carbapenems. imiH antibiotic_resistance ARO:3003094 imiH ARO:3003094 imiH is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas hydrophila. This enzyme has specific activity against carbapenems. PMID:12746371 imiH imiS is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas veronii. This enzyme has specific activity against carbapenems. imiS antibiotic_resistance ARO:3003095 imiS ARO:3003095 imiS is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas veronii. This enzyme has specific activity against carbapenems. PMID:9527802 imiS CfxA5 beta-lactamase is a class A beta-lactamase found in Bacteroides distasonis. CfxA5 antibiotic_resistance ARO:3003096 CfxA5 ARO:3003096 CfxA5 beta-lactamase is a class A beta-lactamase found in Bacteroides distasonis. PMID:24606061 CfxA5 CfxA6 beta-lactamase is a class A beta-lactamase found in an uncultured bacterium. CfxA6 antibiotic_resistance ARO:3003097 CfxA6 ARO:3003097 CfxA6 beta-lactamase is a class A beta-lactamase found in an uncultured bacterium. PMID:19713526 CfxA6 CphA2 is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas hydrophila. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein. PDB:2QDS cphA2 antibiotic_resistance ARO:3003099 cphA2 ARO:3003099 CphA2 is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas hydrophila. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein. PMID:22009263 PMID:9021171 cphA2 CphA4 is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas allosaccharophila. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein. cphA4 antibiotic_resistance ARO:3003100 cphA4 ARO:3003100 cphA4 cphA5 is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas salmonicida. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein. cphA5 antibiotic_resistance ARO:3003101 cphA5 ARO:3003101 cphA5 cphA6 is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas veronii. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein. cphA6 antibiotic_resistance ARO:3003102 cphA6 ARO:3003102 cphA6 cphA7 is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas jandaei. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein. cphA7 antibiotic_resistance ARO:3003103 cphA7 ARO:3003103 cphA7 cphA8 is an Ambler Class B MBL; subclass B2 originally isolated from Aeromonas sobria. This enzyme has specific activity against carbapenems and is active as a mono-zinc protein. cphA8 antibiotic_resistance ARO:3003104 cphA8 ARO:3003104 cphA8 dfrA3 is an integron-encoded dihydrofolate reductase found in Escherichia coli. dfrA3 antibiotic_resistance ARO:3003105 dfrA3 ARO:3003105 dfrA3 is an integron-encoded dihydrofolate reductase found in Escherichia coli. PMID:20169085 dfrA3 Erm42 confers MLSb phenotype in Pasteurella multocida. Erm(42) Erm42 antibiotic_resistance ARO:3003106 Erm(42) ARO:3003106 Erm42 confers MLSb phenotype in Pasteurella multocida. PMID:21402855 Erm(42) mef(B) is a macrolide efflux gene located in the vicinity of sul3 in Escherichia coli. There is also a mefB found in Streptococcus agalactiae that confers resistance to macrolides. mef(B) mefB antibiotic_resistance ARO:3003107 mef(B) ARO:3003107 mef(B) is a macrolide efflux gene located in the vicinity of sul3 in Escherichia coli. There is also a mefB found in Streptococcus agalactiae that confers resistance to macrolides. PMID:19131424 PMID:27052334 mef(B) MsrE is an ABC-F subfamily protein expressed to Klebsiella pneumoniae that confers resistance to erythromycin and streptogramin B antibiotics. It is associated with plasmid DNA. It is also 100% identical to ABC-F type ribosomal protection protein Msr(E) which is in multiple species. msr(E) msrE antibiotic_resistance ARO:3003109 msrE ARO:3003109 MsrE is an ABC-F subfamily protein expressed to Klebsiella pneumoniae that confers resistance to erythromycin and streptogramin B antibiotics. It is associated with plasmid DNA. It is also 100% identical to ABC-F type ribosomal protection protein Msr(E) which is in multiple species. PMID:23114767 msrE catB10 is an integron-encoded variant of the cat gene found in P. aeruginosa. catB10 antibiotic_resistance ARO:3003110 catB10 ARO:3003110 catB10 is an integron-encoded variant of the cat gene found in P. aeruginosa. PMID:20735174 catB10 LsaB is an ABC-F subfamily protein expressed in Mammaliicoccus sciuri. It confers resistance to clindamycin. lsaB antibiotic_resistance ARO:3003111 lsaB ARO:3003111 LsaB is an ABC-F subfamily protein expressed in Mammaliicoccus sciuri. It confers resistance to clindamycin. PMID:15471995 PMID:21245447 lsaB LsaC is an ABC-F subfamily protein expressed in Streptococcus agalactiae. It confers resistance to lincomycin, clindamycin, dalfopristin, and tiamulin. lsaC antibiotic_resistance ARO:3003112 lsaC ARO:3003112 LsaC is an ABC-F subfamily protein expressed in Streptococcus agalactiae. It confers resistance to lincomycin, clindamycin, dalfopristin, and tiamulin. PMID:21245447 lsaC TEM-221 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3003113 TEM-221 ARO:3003113 TEM-222 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3003114 TEM-222 ARO:3003114 OXA-427 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-427 antibiotic_resistance ARO:3003115 OXA-427 ARO:3003115 OXA-427 OXA-420 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-420 antibiotic_resistance ARO:3003116 OXA-420 ARO:3003116 OXA-420 OXA-421 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-421 antibiotic_resistance ARO:3003117 OXA-421 ARO:3003117 OXA-421 OXA-428 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3003119 OXA-428 ARO:3003119 OXA-429 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-429 antibiotic_resistance ARO:3003120 OXA-429 ARO:3003120 OXA-429 OXA-430 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-430 antibiotic_resistance ARO:3003121 OXA-430 ARO:3003121 OXA-430 OXA-431 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-431 antibiotic_resistance ARO:3003124 OXA-431 ARO:3003124 OXA-431 OXA-432 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-432 antibiotic_resistance ARO:3003125 OXA-432 ARO:3003125 OXA-432 OXA-433 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-433 antibiotic_resistance ARO:3003126 OXA-433 ARO:3003126 OXA-433 OXA-434 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3003127 OXA-434 ARO:3003127 An OXA-48-like plasmid-encoded beta-lactamase shown to confer resistance to carbapenems through hydrolysis. Identified in multiple Enterobacteriaceae isolates from several patients in Denmark. Beta-lactamase activity against carbapenems and penicillins but little to no activity against cephalosporin antibiotics. Described by Samuelsen et al. 2017. OXA-436 antibiotic_resistance ARO:3003128 OXA-436 ARO:3003128 An OXA-48-like plasmid-encoded beta-lactamase shown to confer resistance to carbapenems through hydrolysis. Identified in multiple Enterobacteriaceae isolates from several patients in Denmark. Beta-lactamase activity against carbapenems and penicillins but little to no activity against cephalosporin antibiotics. Described by Samuelsen et al. 2017. PMID:29061750 OXA-436 CMY-121 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. CMY-121 antibiotic_resistance ARO:3003129 CMY-121 ARO:3003129 CMY-121 CMY-122 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. CMY-122 antibiotic_resistance ARO:3003130 CMY-122 ARO:3003130 CMY-122 CMY-123 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3003131 CMY-123 ARO:3003131 CMY-124 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. CMY-124 antibiotic_resistance ARO:3003132 CMY-124 ARO:3003132 CMY-124 CMY-125 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. CMY-125 antibiotic_resistance ARO:3003133 CMY-125 ARO:3003133 CMY-125 CMY-126 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3003134 CMY-126 ARO:3003134 CMY-127 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. CMY-127 antibiotic_resistance ARO:3003135 CMY-127 ARO:3003135 CMY-127 CMY-128 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. CMY-128 antibiotic_resistance ARO:3003136 CMY-128 ARO:3003136 CMY-128 CMY-129 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. CMY-129 antibiotic_resistance ARO:3003137 CMY-129 ARO:3003137 CMY-129 CMY-130 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. CMY-130 antibiotic_resistance ARO:3003138 CMY-130 ARO:3003138 CMY-130 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. PMID:26048440 CMY-130 MIR-18 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. MIR-18 antibiotic_resistance ARO:3003139 MIR-18 ARO:3003139 MIR-18 MOX-10 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. MOX-10 antibiotic_resistance ARO:3003140 MOX-10 ARO:3003140 MOX-10 MOX-11 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. MOX-11 antibiotic_resistance ARO:3003141 MOX-11 ARO:3003141 MOX-11 IMI-8 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. IMI-8 antibiotic_resistance ARO:3003142 IMI-8 ARO:3003142 IMI-8 IMI-9 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. IMI-9 antibiotic_resistance ARO:3003143 IMI-9 ARO:3003143 IMI-9 KPC-20 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3003144 KPC-20 ARO:3003144 KPC-21 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. KPC-21 antibiotic_resistance ARO:3003145 KPC-21 ARO:3003145 KPC-21 VEB-10 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. VEB-10 antibiotic_resistance ARO:3003146 VEB-10 ARO:3003146 VEB-10 OXA-424 is a beta-lactamase found in clinical isolates of Acinetobacter baumannii found in China. It is carbapenem resistant. OXA-424 antibiotic_resistance ARO:3003147 OXA-424 ARO:3003147 OXA-424 is a beta-lactamase found in clinical isolates of Acinetobacter baumannii found in China. It is carbapenem resistant. PMID:25487793 OXA-424 OXA-425 is a beta-lactamase found in clinical isolates of Acinetobacter baumannii. It is carbapenem-resistant. OXA-425 antibiotic_resistance ARO:3003148 OXA-425 ARO:3003148 OXA-425 is a beta-lactamase found in clinical isolates of Acinetobacter baumannii. It is carbapenem-resistant. PMID:25487793 OXA-425 OXA-426 is a beta-lactamase found in clinical isolates of Acinetobacter baumannii. It is carbapenem resistant. OXA-426 antibiotic_resistance ARO:3003149 OXA-426 ARO:3003149 OXA-426 is a beta-lactamase found in clinical isolates of Acinetobacter baumannii. It is carbapenem resistant. PMID:25487793 OXA-426 CARB-20 is a beta-lactamase found worldwide in Vibrio parahaemolyticus. CARB-20 antibiotic_resistance ARO:3003150 CARB-20 ARO:3003150 CARB-20 is a beta-lactamase found worldwide in Vibrio parahaemolyticus. PMID:23469330 CARB-20 CARB-22 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CARB-22 antibiotic_resistance ARO:3003151 CARB-22 ARO:3003151 CARB-22 SHV-185 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. SHV-185 antibiotic_resistance ARO:3003152 SHV-185 ARO:3003152 SHV-185 SHV-186 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. SHV-186 antibiotic_resistance ARO:3003153 SHV-186 ARO:3003153 SHV-186 SHV-187 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. SHV-187 antibiotic_resistance ARO:3003154 SHV-187 ARO:3003154 SHV-187 SHV-188 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. SHV-188 antibiotic_resistance ARO:3003155 SHV-188 ARO:3003155 SHV-188 SHV-189 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. SHV-189 antibiotic_resistance ARO:3003156 SHV-189 ARO:3003156 SHV-189 TEM-219 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. TEM-219 antibiotic_resistance ARO:3003157 TEM-219 ARO:3003157 TEM-219 TEM-220 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. TEM-220 antibiotic_resistance ARO:3003158 TEM-220 ARO:3003158 TEM-220 OXA-419 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3003159 OXA-419 ARO:3003159 OXA-422 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-422 antibiotic_resistance ARO:3003160 OXA-422 ARO:3003160 OXA-422 OXA-423 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-423 antibiotic_resistance ARO:3003161 OXA-423 ARO:3003161 OXA-423 OXA-435 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-435 antibiotic_resistance ARO:3003162 OXA-435 ARO:3003162 OXA-435 CTX-M-155 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-155 antibiotic_resistance ARO:3003163 CTX-M-155 ARO:3003163 CTX-M-155 CTX-M-156 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-156 antibiotic_resistance ARO:3003164 CTX-M-156 ARO:3003164 CTX-M-156 CTX-M-157 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-157 antibiotic_resistance ARO:3003165 CTX-M-157 ARO:3003165 CTX-M-157 CTX-M-158 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-158 antibiotic_resistance ARO:3003166 CTX-M-158 ARO:3003166 CTX-M-158 CTX-M-159 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-159 antibiotic_resistance ARO:3003167 CTX-M-159 ARO:3003167 CTX-M-159 CTX-M-160 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-160 antibiotic_resistance ARO:3003168 CTX-M-160 ARO:3003168 CTX-M-160 CTX-M-161 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-161 antibiotic_resistance ARO:3003169 CTX-M-161 ARO:3003169 CTX-M-161 CMY-131 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-131 antibiotic_resistance ARO:3003170 CMY-131 ARO:3003170 CMY-131 ACT-36 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. ACT-36 antibiotic_resistance ARO:3003171 ACT-36 ARO:3003171 ACT-36 ACT-37 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. ACT-37 antibiotic_resistance ARO:3003172 ACT-37 ARO:3003172 ACT-37 MIR-17 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. MIR-17 antibiotic_resistance ARO:3003173 MIR-17 ARO:3003173 MIR-17 CARB-18 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CARB-18 antibiotic_resistance ARO:3003174 CARB-18 ARO:3003174 CARB-18 CARB-19 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CARB-19 antibiotic_resistance ARO:3003175 CARB-19 ARO:3003175 CARB-19 CARB-21 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CARB-21 antibiotic_resistance ARO:3003176 CARB-21 ARO:3003176 CARB-21 IMI-7 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. IMI-7 antibiotic_resistance ARO:3003177 IMI-7 ARO:3003177 IMI-7 VIM-42 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. VIM-42 antibiotic_resistance ARO:3003178 VIM-42 ARO:3003178 VIM-42 VIM-43 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. VIM-43 antibiotic_resistance ARO:3003179 VIM-43 ARO:3003179 VIM-43 KPC-22 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. KPC-22 antibiotic_resistance ARO:3003180 KPC-22 ARO:3003180 KPC-22 GES-26 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. GES-26 antibiotic_resistance ARO:3003181 GES-26 ARO:3003181 GES-26 Beta-lactamase found in Escherichia coli clinical isolates in Nepal. NDM-13 antibiotic_resistance ARO:3003182 NDM-13 ARO:3003182 Beta-lactamase found in Escherichia coli clinical isolates in Nepal. PMID:26169399 NDM-13 NDM-14 is a beta-lactamase found in Acinetobacter lwoffii. NDM-14 antibiotic_resistance ARO:3003183 NDM-14 ARO:3003183 NDM-14 is a beta-lactamase found in Acinetobacter lwoffii. PMID:25645836 NDM-14 PER-8 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. PER-8 antibiotic_resistance ARO:3003184 PER-8 ARO:3003184 PER-8 GES-25 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. GES-25 antibiotic_resistance ARO:3003185 GES-25 ARO:3003185 GES-25 CARB-23 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CARB-23 antibiotic_resistance ARO:3003186 CARB-23 ARO:3003186 CARB-23 QnrB75 is a fluoroquinolone resistance gene in Lahey's list of qnr genes. QnrB75 antibiotic_resistance ARO:3003187 QnrB75 ARO:3003187 QnrB75 QnrB76 is a fluoroquinolone resistance gene in Lahey's list of qnr genes. QnrB76 antibiotic_resistance ARO:3003188 QnrB76 ARO:3003188 QnrB76 QnrB77 is a fluoroquinolone resistance gene in Lahey's list of qnr genes. QnrB77 antibiotic_resistance ARO:3003189 QnrB77 ARO:3003189 QnrB77 QnrB78 is a fluoroquinolone resistance gene in Lahey's list of qnr genes. QnrB78 antibiotic_resistance ARO:3003190 QnrB78 ARO:3003190 QnrB78 QnrB80 is a fluoroquinolone resistance gene in Lahey's list of qnr genes. QnrB80 antibiotic_resistance ARO:3003192 QnrB80 ARO:3003192 QnrB80 QnrVC7 is a fluoroquinolone resistance gene in Lahey's list of qnr genes. QnrVC7 antibiotic_resistance ARO:3003193 QnrVC7 ARO:3003193 QnrVC7 is a fluoroquinolone resistance gene in Lahey's list of qnr genes. PMID:23595824 QnrVC7 GIM-2 is a metallo-beta-lactamase present on an integron found in clinical isolates of Enterobacter cloacae in Germany. GIM-2 antibiotic_resistance ARO:3003194 GIM-2 ARO:3003194 GIM-2 GIM beta-lactamase enzymes isolated from Pseudomonas aeruginosa, and found to confer broad-spectrum resistance to beta-lactam antibiotics. blaGIM-1 antibiotic_resistance ARO:3003195 GIM beta-lactamase ARO:3003195 GIM beta-lactamase enzymes isolated from Pseudomonas aeruginosa, and found to confer broad-spectrum resistance to beta-lactam antibiotics. PMID:15561840 Tet45 is a tetracycline efflux pump found in Bhargavaea cecembensis strain previously isolated from a poultry-litter-impacted soil. tet(45) tet45 antibiotic_resistance ARO:3003196 tet(45) ARO:3003196 Tet45 is a tetracycline efflux pump found in Bhargavaea cecembensis strain previously isolated from a poultry-litter-impacted soil. PMID:22001175 PMID:23595824 tet(45) Streptomycin/spectinomycin resistance gene found in Pasteurella multocida isolated from bovine respiratory tract. aadA25 antibiotic_resistance ARO:3003197 aadA25 ARO:3003197 Streptomycin/spectinomycin resistance gene found in Pasteurella multocida isolated from bovine respiratory tract. PMID:22001175 aadA25 rmtH is a 16s ribosomal RNA methyltransferase found in Klebsiella pneumoniae strain MRSN2404 that was isolated from the chronic wound of a soldier wounded in Iraq in 2006. It confers high resistance to aminoglycosides. rmtH antibiotic_resistance ARO:3003198 rmtH ARO:3003198 rmtH is a 16s ribosomal RNA methyltransferase found in Klebsiella pneumoniae strain MRSN2404 that was isolated from the chronic wound of a soldier wounded in Iraq in 2006. It confers high resistance to aminoglycosides. PMID:23478957 rmtH AAC(6')-Iak is a 6'-N-aminoglycoside acetyltransferase-encoding gene isolated from a multidrug-resistant clinical isolate of Stenotrophomonas maltophilia. AAC(6')-Iak antibiotic_resistance ARO:3003199 AAC(6')-Iak ARO:3003199 AAC(6')-Iak is a 6'-N-aminoglycoside acetyltransferase-encoding gene isolated from a multidrug-resistant clinical isolate of Stenotrophomonas maltophilia. PMID:25092711 AAC(6')-Iak AAC(6')-Ian is an amikacin acetyltransferase gene found on a transferable plasmid of the Serratia marcescens strain NUBL-11663. It catalyzes the transfer of an acetyl group from acetyl coenzyme A onto an amine at the 6'-position of various aminoglycosides. AAC(6')-Ian antibiotic_resistance ARO:3003200 AAC(6')-Ian ARO:3003200 AAC(6')-Ian is an amikacin acetyltransferase gene found on a transferable plasmid of the Serratia marcescens strain NUBL-11663. It catalyzes the transfer of an acetyl group from acetyl coenzyme A onto an amine at the 6'-position of various aminoglycosides. PMID:25576529 AAC(6')-Ian The TLA beta-lactamases are resistant to expanded-spectrum cephalosporins, and aztreonam but was susceptible to amikacin, cefotetan, and imipenem. antibiotic_resistance ARO:3003201 TLA beta-lactamase ARO:3003201 TLA-1 is a beta-lactamase found in plasmids of clinical isolates of Escherichia coli strain R170 in Latin America. It preferentially hydrolyzed cephaloridine, cefotaxime, cephalothin, benzylpenicillin, and ceftazidime. The enzyme was markedly inhibited by sulbactam, tazobactam, and clavulanic acid. TLA-1 antibiotic_resistance ARO:3003202 TLA-1 ARO:3003202 TLA-1 is a beta-lactamase found in plasmids of clinical isolates of Escherichia coli strain R170 in Latin America. It preferentially hydrolyzed cephaloridine, cefotaxime, cephalothin, benzylpenicillin, and ceftazidime. The enzyme was markedly inhibited by sulbactam, tazobactam, and clavulanic acid. PMID:15095209 TLA-1 TLA-2 is a beta-lactamase is present on a plasmid isolated from an unidentified bacterial strain from a waste water treatment plant. The enzyme mostly hydrolyzes cephalosporins. TLA-2 antibiotic_resistance ARO:3003203 TLA-2 ARO:3003203 TLA-2 is a beta-lactamase is present on a plasmid isolated from an unidentified bacterial strain from a waste water treatment plant. The enzyme mostly hydrolyzes cephalosporins. PMID:16251326 TLA-2 TLA-3 is a beta-lactamase found in a transferable plasmid of Serratia marcescens clinical isolate. It confers resistance to ceftazidime, cefotaxime and cefepime, but not to cefmetazole and meropenem. TLA-3 antibiotic_resistance ARO:3003204 TLA-3 ARO:3003204 TLA-3 is a beta-lactamase found in a transferable plasmid of Serratia marcescens clinical isolate. It confers resistance to ceftazidime, cefotaxime and cefepime, but not to cefmetazole and meropenem. PMID:25576529 TLA-3 Erm(43) is a macrolide, lincosamide, and streptogramin B resistance gene found in Mammaliicoccus lentus chromosome isolated from human, dog and chicken. Erm(43) antibiotic_resistance ARO:3003205 Erm(43) ARO:3003205 Erm(43) is a macrolide, lincosamide, and streptogramin B resistance gene found in Mammaliicoccus lentus chromosome isolated from human, dog and chicken. PMID:22733067 Erm(43) lsaE is an ABC-F subfamily protein found in porcine MRSA isolates. It confers resistance to pleuromutilin, lincosamide, and streptogramin A. lsaE antibiotic_resistance ARO:3003206 lsaE ARO:3003206 lsaE is an ABC-F subfamily protein found in porcine MRSA isolates. It confers resistance to pleuromutilin, lincosamide, and streptogramin A. PMID:21245447 PMID:23386262 lsaE FosK is a fosfomycin thiol transferase isolated from Acinetobacter soli. It is integrin-mediated. It confers a high level of resistance to fosfomycin. FosK antibiotic_resistance ARO:3003207 FosK ARO:3003207 FosK is a fosfomycin thiol transferase isolated from Acinetobacter soli. It is integrin-mediated. It confers a high level of resistance to fosfomycin. PMID:24841262 FosK fosXCC is a fosfomycin resistance gene that modifies MurA isolated from Campylobacter species. It is highly resistant to fosfomycin. FosXCC antibiotic_resistance ARO:3003208 FosXCC ARO:3003208 fosXCC is a fosfomycin resistance gene that modifies MurA isolated from Campylobacter species. It is highly resistant to fosfomycin. PMID:25433007 FosXCC fosA5 is a fosfomycin resistance gene isolated from clinical strain of Escherichia coli E265. It is susceptible to amikacin, tetracycline and imipenem, and resistant to sulphonamide, cephalosporins, gentamicin, ciprofloxacin, chloramphenicol and streptomycin. fosA5 antibiotic_resistance ARO:3003209 fosA5 ARO:3003209 fosA5 is a fosfomycin resistance gene isolated from clinical strain of Escherichia coli E265. It is susceptible to amikacin, tetracycline and imipenem, and resistant to sulphonamide, cephalosporins, gentamicin, ciprofloxacin, chloramphenicol and streptomycin. PMID:25441705 fosA5 FosA4 is an enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule. FosA4 antibiotic_resistance ARO:3003210 FosA4 ARO:3003210 FosA4 is an enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule. PMID:24951800 FosA4 Many antibiotics inhibit the growth of bacteria by blocking protein synthesis on the ribosome. The antibiotic-binding sites are located within functionally important structures in the ribosomal RNA. Antibiotic resistance is often conferred by base substitutions or methylations at these sites in the rRNA. Point mutations in the bacterial 16S ribosomal RNA in the small 30S subunit can confer resistance to antibiotics. antibiotic_resistance ARO:3003211 16S rRNA with mutation conferring antibiotic resistance ARO:3003211 Many antibiotics inhibit the growth of bacteria by blocking protein synthesis on the ribosome. The antibiotic-binding sites are located within functionally important structures in the ribosomal RNA. Antibiotic resistance is often conferred by base substitutions or methylations at these sites in the rRNA. Point mutations in the bacterial 16S ribosomal RNA in the small 30S subunit can confer resistance to antibiotics. PMID:16261170 PMID:16269538 PMID:8065453 Point mutations in the 3' minor domain of the 16S rRNA in Escherichia coli can confer resistance to edeine. Ecol_16S_EDN antibiotic_resistance ARO:3003223 Escherichia coli 16S rRNA mutation conferring resistance to edeine ARO:3003223 Point mutations in the 3' minor domain of the 16S rRNA in Escherichia coli can confer resistance to edeine. PMID:16269538 Ecol_16S_EDN Precursor molecule during the synthesis of bacterial cell wall. Lipid II anchors itself onto the cell and it's disaccharide-peptide subunit is used in PG polymer assembly by peptidoglycan glycosyltransferases. Due to it's importance in cell wall synthesis, it is the target of antibiotics. antibiotic_resistance ARO:3003231 Lipid II ARO:3003231 Precursor molecule during the synthesis of bacterial cell wall. Lipid II anchors itself onto the cell and it's disaccharide-peptide subunit is used in PG polymer assembly by peptidoglycan glycosyltransferases. Due to it's importance in cell wall synthesis, it is the target of antibiotics. PMID:25291014 Lipid III is the precursor to the wall teichoic acid. It's inhibition leads to bacterial death as teichoic acid is required to anchor autolysins which control the hydrolysis of peptidoglycan cell wall. Undecaprenyl Pyrophosphate N-Acetylglucosamine Undecaprenyl-PP-GlcNAc antibiotic_resistance ARO:3003232 Lipid III ARO:3003232 Lipid III is the precursor to the wall teichoic acid. It's inhibition leads to bacterial death as teichoic acid is required to anchor autolysins which control the hydrolysis of peptidoglycan cell wall. PMID:25561178 Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to kanamycin. Mabs_16S_KAN antibiotic_resistance ARO:3003236 Mycobacteroides abscessus 16S rRNA mutation conferring resistance to kanamycin ARO:3003236 Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to kanamycin. PMID:21652621 PMID:9607835 Mabs_16S_KAN Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to tobramycin. Mabs_16S_TOB antibiotic_resistance ARO:3003237 Mycobacteroides abscessus 16S rRNA mutation conferring resistance to tobramycin ARO:3003237 Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to tobramycin. PMID:21652621 PMID:9607835 Mabs_16S_TOB Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to neomycin. Mabs_16S_NEO antibiotic_resistance ARO:3003238 Mycobacteroides abscessus 16S rRNA mutation conferring resistance to neomycin ARO:3003238 Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to neomycin. PMID:9607835 Mabs_16S_NEO Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to amikacin. Mabs_16S_AMK antibiotic_resistance ARO:3003239 Mycobacteroides abscessus 16S rRNA mutation conferring resistance to amikacin ARO:3003239 Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to amikacin. PMID:21652621 PMID:9607835 Mabs_16S_AMK Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to gentamicin. Mabs_16S_GEN antibiotic_resistance ARO:3003240 Mycobacteroides abscessus 16S rRNA mutation conferring resistance to gentamicin ARO:3003240 Point mutations in the 16S rRNA of Mycobacteroides abscessus conferring resistance to gentamicin. PMID:21652621 PMID:9607835 Mabs_16S_GEN Teixobactin is a peptide antibiotic isolated from the Gram-negative bacteria, Eleftheria terrae. It inhibits the synthesis of peptidoglycan by interacting with peptidoglycan precursor, Lipid II and Lipid III. ChEBI:84192 ChEMBL:CHEMBL3977597 PubChem:86341926 antibiotic_resistance ARO:3003241 teixobactin ARO:3003241 Teixobactin is a peptide antibiotic isolated from the Gram-negative bacteria, Eleftheria terrae. It inhibits the synthesis of peptidoglycan by interacting with peptidoglycan precursor, Lipid II and Lipid III. PMID:25561178 The bcrC gene product (BcrC) is an undecaprenyl pyrophosphate phosphatase originally isolated from Bacillus subtilis. When overexpressed it can confer resistance to bacitracin. bcrC antibiotic_resistance ARO:3003250 bcrC ARO:3003250 The bcrC gene product (BcrC) is an undecaprenyl pyrophosphate phosphatase originally isolated from Bacillus subtilis. When overexpressed it can confer resistance to bacitracin. PMID:15946938 bcrC Undecaprenyl pyrophosphate is a precursor to a cell wall polymer carrier. It's activation requires a phosphatase. antibiotic_resistance ARO:3003251 undecaprenyl pyrophosphate ARO:3003251 Subunit of topoisomerase IV sensitive to aminocourmarins. antibiotic_resistance ARO:3003253 aminocoumarin sensitive parY ARO:3003253 Subunit of topoisomerase IV sensitive to aminocourmarins. PMID:1260451 DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Binding the alpha-subunit is sufficient to inhibit DNA supercoiling. antibiotic_resistance ARO:3003254 antibiotic sensitive DNA topoisomerase subunit gyrA ARO:3003254 DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Binding the alpha-subunit is sufficient to inhibit DNA supercoiling. PMID:1657531 ParC is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Targeting topoisomerase IV inhibits DNA synthesis, and may also lead to double-stranded cell breaks. antibiotic_resistance ARO:3003256 antibiotic sensitive DNA topoisomerase subunit parC ARO:3003256 ParC is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Targeting topoisomerase IV inhibits DNA synthesis, and may also lead to double-stranded cell breaks. PMID:1657531 parY is a subunit of the topoisomerase IV. It decatenates and relaxes DNA to allow for transcription or translation. antibiotic_resistance ARO:3003258 Antibiotic sensitive DNA topoisomerase subunit parY ARO:3003258 ParE is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Targeting topoisomerase IV inhibits DNA synthesis, and may also lead to double-stranded cell breaks. antibiotic_resistance ARO:3003259 antibiotic sensitive DNA topoisomerase subunit parE ARO:3003259 ParE is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Targeting topoisomerase IV inhibits DNA synthesis, and may also lead to double-stranded cell breaks. PMID:12604514 Beta-subunit of DNA gyrase sensitive to inhibition by aminocoumarins. antibiotic_resistance ARO:3003260 aminocoumarin sensitive gyrB ARO:3003260 Beta-subunit of DNA gyrase sensitive to inhibition by fluoroquinolones. antibiotic_resistance ARO:3003261 fluoroquinolone sensitive gyrB ARO:3003261 Sensitive form of 16s susceptable to antibiotics. antibiotic_resistance ARO:3003262 Antibiotic sensitive Escherichia coli 16S rRNA ARO:3003262 Sensitive form of 16s susceptible to antibiotics. antibiotic_resistance ARO:3003263 Antibiotic sensitive Mycobacteroides abscessus 16S rRNA ARO:3003263 Sensitive form of 16s susceptible to antibiotics. antibiotic_resistance ARO:3003264 Aminoglycosides sensitive Mycobacteroides abscessus 16S rRNA ARO:3003264 Sensitive form of 16s susceptible to antibiotics. antibiotic_resistance ARO:3003265 Amikacin sensitive Mycobacteroides abscessus 16S rRNA mutation ARO:3003265 Cardiolipin synthetase catalyzes the formation of cardiolipin from two phosphatidylglycerol molecules. Cardiolipin is important in membrane translocation and permeabilization. Current known mutations on the enzyme confer resistance to daptomycin. cardiolipin synthetase antibiotic_resistance ARO:3003272 daptomycin resistant cls ARO:3003272 Cardiolipin synthetase catalyzes the formation of cardiolipin from two phosphatidylglycerol molecules. Cardiolipin is important in membrane translocation and permeabilization. Current known mutations on the enzyme confer resistance to daptomycin. PMID:23114777 PMID:9370333 Interaction with the cell membrane phospholipids interferes with membrane permeability and integrity, leading to the leakage of cell contents. The outer membrane of Gram-negative bacteria is particularly sensitive. antibiotic_resistance ARO:3003273 cell membrane component enzymes targeted by antibiotic ARO:3003273 Cardiolipin synthetase catalyzes the formation of cardiolipin from two phosphatidylglycerol molecules. Cardiolipin is important in membrane translocation and permeabilization. The inactivation of this enzyme by antibiotics leads to cell death. antibiotic_resistance ARO:3003274 antibiotic sensitive cls ARO:3003274 Cardiolipin synthetase catalyzes the formation of cardiolipin from two phosphatidylglycerol molecules. Cardiolipin is important in membrane translocation and permeabilization. Mutations on the enzyme confers resistance to Daptomycin. antibiotic_resistance ARO:3003275 Daptomycin sensitive cardiolipin synthetase ARO:3003275 Cardiolipin synthetase catalyzes the formation of cardiolipin from two phosphatidylglycerol molecules. Cardiolipin is important in membrane translocation and permeabilization. Mutations on the enzyme confers resistance to Daptomycin. PMID:21899450 RNA polymerase is a multisubunit enzyme that is necessary for transcription. The beta-subunit of RNA polymerase forms the active center of the enzyme and template/transcript binding sites. Mutations in rpoB gene confers antibiotic resistance. RNA polymerase beta subunit antibiotic_resistance ARO:3003276 antibiotic resistant rpoB ARO:3003276 RNA polymerase is a multisubunit enzyme that is necessary for transcription. The beta-subunit of RNA polymerase forms the active center of the enzyme and template/transcript binding sites. This enzyme can be inactivated by antibiotics leading to cell death. antibiotic_resistance ARO:3003277 antibiotic sensitive beta-subunit of RNA polymerase (rpoB) ARO:3003277 Daptomycin binds to the cytoplasmic membrane of Gram-positive. It's lipopeptide tail servers as a ion channel for potassium. This causes a rapid depolarization that result in failures in DNA/RNA/Protein synthesis. Eventually cell death. antibiotic_resistance ARO:3003278 daptomycin sensitive beta-subunit of RNA polymerase (rpoB) ARO:3003278 Daptomycin binds to the cytoplasmic membrane of Gram-positive. It's lipopeptide tail servers as a ion channel for potassium. This causes a rapid depolarization that result in failures in DNA/RNA/Protein synthesis. Eventually cell death. PMID:20837752 The liaFSR system regulates the cell envelope stress response. It is transcriptionally activated by exposure to alkaline shock, detergents, and particularly antibiotics with lipid II inhibition properties. antibiotic_resistance ARO:3003279 antibiotic resistant liaFSR system ARO:3003279 The liaFSR system regulates the cell envelope stress response. It is transcriptionally activated by exposure to alkaline shock, detergents, and particularly antibiotics with lipid II inhibition properties. PMID:19251860 MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface of both Gram-positive and Gram-negative bacteria. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. Mutations in this enzyme can confer additional resistances. antibiotic_resistance ARO:3003280 antibiotic sensitive mprF ARO:3003280 MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface of both Gram-positive and Gram-negative bacteria. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. Mutations in this enzyme can confer additional resistances. PMID:16723576 PMID:20498310 pgsA or phosphatidylglycerophosphate synthetase is an integral membrane protein involved in phospholipid biosynthesis. Inhibition of this enzyme leads to cell death via the inability to form the plasma membrane. antibiotic_resistance ARO:3003281 antibiotic sensitive pgsA ARO:3003281 pgsA or phosphatidylglycerophosphate synthetase is an integral membrane protein involved in phospholipid biosynthesis. Inhibition of this enzyme leads to cell death via the inability to form the plasma membrane. PMID:21709092 Point mutations that occurs in Mycobacterium tuberculosis rpoB resulting in resistance to rifampicin. Mtub_rpoB_RIF Rv0667 antibiotic_resistance ARO:3003283 Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin ARO:3003283 Point mutations that occurs in Mycobacterium tuberculosis rpoB resulting in resistance to rifampicin. ISBN:978-92-4-008241-0 PMID:10074552 PMID:10423225 PMID:10645439 PMID:10722516 PMID:10921994 PMID:11136757 PMID:11474030 PMID:11796356 PMID:12454132 PMID:15047531 PMID:15184414 PMID:15728936 PMID:15814606 PMID:17108078 PMID:17360809 PMID:17970586 PMID:18294243 PMID:18600483 PMID:18653964 PMID:19520715 PMID:19547874 PMID:19721079 PMID:21300839 PMID:22708343 PMID:25427352 PMID:28904673 PMID:30337678 PMID:31100498 PMID:35944069 PMID:7840574 PMID:7914261 PMID:8027320 PMID:8095569 PMID:8870258 PMID:9003625 Mtub_rpoB_RIF Point mutations that occurs in Mycobacterium leprae rpoB resulting in resistance to rifampicin. Mlep_rpoB_RIF antibiotic_resistance ARO:3003284 Mycobacterium leprae rpoB mutations conferring resistance to rifampicin ARO:3003284 Point mutations that occurs in Mycobacterium leprae rpoB resulting in resistance to rifampicin. PMID:15603834 Mlep_rpoB_RIF Point mutations that occurs in Staphylococcus aureus rpoB resulting in resistance to rifampicin. Saur_rpoB_RIF antibiotic_resistance ARO:3003285 Staphylococcus aureus rpoB mutants conferring resistance to rifampicin ARO:3003285 Point mutations that occurs in Staphylococcus aureus rpoB resulting in resistance to rifampicin. PMID:10543773 Saur_rpoB_RIF Point mutations that occurs in Staphylococcus aureus rpoB resulting in resistance to daptomycin. Saur_rpoB_DAP antibiotic_resistance ARO:3003287 Staphylococcus aureus rpoB mutants conferring resistance to daptomycin ARO:3003287 Point mutations that occurs in Staphylococcus aureus rpoB resulting in resistance to daptomycin. PMID:16723576 PMID:20837752 Saur_rpoB_DAP Point mutations that occurs in Escherichia coli rpoB resulting in resistance to rifampicin. Ecol_rpoB_RIF antibiotic_resistance ARO:3003288 Escherichia coli rpoB mutants conferring resistance to rifampicin ARO:3003288 Point mutations that occurs in Escherichia coli rpoB resulting in resistance to rifampicin. PMID:3050121 PMID:31992637 Ecol_rpoB_RIF RNA polymerase is a multisubunit enzyme that is necessary for transcription. The beta prime subunit of RNA polymerase forms the active center of the enzyme and template/transcript binding sites. Mutations in rpoC gene confers antibiotic resistance. RNA polymerase beta-prime subunit antibiotic_resistance ARO:3003289 antibiotic resistant rpoC ARO:3003289 Daptomycin resistant RNA polymerases include amino acids substitutions which alter the binding affinity of daptomycin to the protein, resulting in antibiotic resistance. antibiotic_resistance ARO:3003290 daptomycin-resistant beta prime subunit of RNA polymerase (rpoC) ARO:3003290 Point mutations that occurs in Staphylococcus aureus rpoC resulting in resistance to daptomycin. Saur_rpoC_DAP antibiotic_resistance ARO:3003291 Staphylococcus aureus rpoC conferring resistance to daptomycin ARO:3003291 Point mutations that occurs in Staphylococcus aureus rpoC resulting in resistance to daptomycin. PMID:16723576 Saur_rpoC_DAP DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. GyrA point mutations confer resistance by preventing fluoroquinolone antibiotics from binding the alpha-subunit. antibiotic_resistance ARO:3003292 fluoroquinolone resistant gyrA ARO:3003292 DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. GyrA point mutations confer resistance by preventing fluoroquinolone antibiotics from binding the alpha-subunit. PMID:12499219 PMID:1850972 PMID:22279180 PMID:22371897 PMID:9293187 Point mutation of Escherichia coli gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance. Ecol_gyrA_FLO antibiotic_resistance ARO:3003294 Escherichia coli gyrA conferring resistance to fluoroquinolones ARO:3003294 Point mutation of Escherichia coli gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance. PMID:1850972 PMID:2168148 PMID:2548439 PMID:25631675 PMID:7840592 PMID:8388197 Ecol_gyrA_FLO Point mutation of Mycobacterium tuberculosis gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance. Mtub_gyrA_FLO Rv0006 antibiotic_resistance ARO:3003295 Mycobacterium tuberculosis gyrA conferring resistance to fluoroquinolones ARO:3003295 Point mutation of Mycobacterium tuberculosis gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance. ISBN:978-92-4-008241-0 PMID:16377674 PMID:16584301 PMID:17015625 PMID:17035499 PMID:17434825 PMID:19687244 PMID:21300839 PMID:27847014 PMID:30337678 PMID:35944069 PMID:8031045 Mtub_gyrA_FLO Point mutation of Staphylococcus aureus gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance. Saur_gyrA_FLO antibiotic_resistance ARO:3003296 Staphylococcus aureus gyrA conferring resistance to fluoroquinolones ARO:3003296 Point mutation of Staphylococcus aureus gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance. PMID:21996946 Saur_gyrA_FLO Point mutation of Bartonella bacilliformis gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance. Bbac_gyrA_FLO antibiotic_resistance ARO:3003297 Bartonella bacilliformis gyrA conferring resistance to fluoroquinolones ARO:3003297 Point mutation of Bartonella bacilliformis gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance. PMID:12499219 Bbac_gyrA_FLO Point mutation of Mycobacterium leprae gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance. Mlep_gyrA_FLO antibiotic_resistance ARO:3003298 Mycobacterium leprae gyrA conferring resistance to fluoroquinolones ARO:3003298 Point mutation of Mycobacterium leprae gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance. PMID:15603834 Mlep_gyrA_FLO Point mutation in Staphylococcus aureus resulting in aminocoumarin resistance. Saur_gyrB_AMU antibiotic_resistance ARO:3003301 Staphylococcus aureus gyrB conferring resistance to aminocoumarin ARO:3003301 Point mutation in Staphylococcus aureus resulting in aminocoumarin resistance. PMID:16127057 Saur_gyrB_AMU Point mutation in Bartonella bacilliformis resulting in aminocoumarin resistance. Bbac_gyrA_AMU antibiotic_resistance ARO:3003302 Bartonella bacilliformis gyrB conferring resistance to aminocoumarin ARO:3003302 Point mutation in Bartonella bacilliformis resulting in aminocoumarin resistance. PMID:9797224 Bbac_gyrA_AMU Point mutation in Escherichia coli resulting in aminocoumarin resistance. Ecol_gyrB_AMU antibiotic_resistance ARO:3003303 Escherichia coli gyrB conferring resistance to aminocoumarin ARO:3003303 Point mutation in Escherichia coli resulting in aminocoumarin resistance. PMID:1323022 Ecol_gyrB_AMU Point mutation in Mycobacterium leprae gyrB resulting in fluoroquinolone resistance. Mlep_gyrB_FLO antibiotic_resistance ARO:3003304 Mycobacterium leprae gyrB conferring resistance to fluoroquinolones ARO:3003304 Point mutation in Mycobacterium leprae gyrB resulting in fluoroquinolone resistance. PMID:23071850 Mlep_gyrB_FLO Point mutation in Ureaplasma urealyticum resulting in fluoroquinolone resistance. Uure_gyrB_FLO antibiotic_resistance ARO:3003305 Ureaplasma urealyticum gyrB conferring resistance to fluoroquinolones ARO:3003305 Point mutation in Ureaplasma urealyticum resulting in fluoroquinolone resistance. PMID:25645833 PMID:27884651 Uure_gyrB_FLO Point mutation in Morganella morganii resulting in fluoroquinolone resistance. Mmor_gyrB_FLO antibiotic_resistance ARO:3003306 Morganella morganii gyrB conferring resistance to fluoroquinolones ARO:3003306 Point mutation in Morganella morganii resulting in fluoroquinolone resistance. PMID:25106550 Mmor_gyrB_FLO Point mutation in Salmonella serovars resulting in fluoroquinolone resistance. Sser_gyrB_FLO antibiotic_resistance ARO:3003307 Salmonella serovars gyrB conferring resistance to fluoroquinolones ARO:3003307 Point mutation in Salmonella serovars resulting in fluoroquinolone resistance. PMID:19104017 Sser_gyrB_FLO Point mutation in Escherichia coli parC resulting in fluoroquinolone resistance. Ecol_parC_FLO antibiotic_resistance ARO:3003308 Escherichia coli parC conferring resistance to fluoroquinolones ARO:3003308 Point mutation in Escherichia coli parC resulting in fluoroquinolone resistance. PMID:25631675 Ecol_parC_FLO Point mutation in Ureaplasma urealyticum parC resulting in fluoroquinolone resistance. Uure_parC_FLO antibiotic_resistance ARO:3003309 Ureaplasma urealyticum parC conferring resistance to fluoroquinolones ARO:3003309 Point mutation in Ureaplasma urealyticum parC resulting in fluoroquinolone resistance. PMID:25645833 PMID:27884651 Uure_parC_FLO Point mutation in Mycoplasma hominis parC resulting in fluoroquinolone resistance. Mhom_23S_FLO antibiotic_resistance ARO:3003310 Mycoplasma hominis parC conferring resistance to fluoroquinolones ARO:3003310 Point mutation in Mycoplasma hominis parC resulting in fluoroquinolone resistance. PMID:24948939 Mhom_23S_FLO Point mutation in Streptococcus pneumoniae parC resulting in fluoroquinolone resistance. Spne_parC_FLO antibiotic_resistance ARO:3003311 Streptococcus pneumoniae parC conferring resistance to fluoroquinolones ARO:3003311 Point mutation in Streptococcus pneumoniae parC resulting in fluoroquinolone resistance. PMID:8913454 Spne_parC_FLO Point mutation in Staphylococcus aureus parC resulting in fluoroquinolone resistance. Saur_parC_FLO antibiotic_resistance ARO:3003312 Staphylococcus aureus parC conferring resistance to fluoroquinolones ARO:3003312 Point mutation in Staphylococcus aureus parC resulting in fluoroquinolone resistance. PMID:21996946 Saur_parC_FLO ParE is a subunit of topoisomerase IV, necessary for cell survival. Point mutations in ParE prevent fluoroquinolones from inhibiting DNA synthesis, thus conferring resistance. antibiotic_resistance ARO:3003313 fluoroquinolone resistant parE ARO:3003313 Point mutation in Staphylococcus aureus parE resulting in aminocoumarin resistance. Saur_parE_AMU grlB antibiotic_resistance ARO:3003314 Staphylococcus aureus parE conferring resistance to aminocoumarin ARO:3003314 Point mutation in Staphylococcus aureus parE resulting in aminocoumarin resistance. PMID:16127057 Saur_parE_AMU Point mutation in Staphylococcus aureus parE resulting in fluoroquinolones resistance. Saur_parE_FLO antibiotic_resistance ARO:3003315 Staphylococcus aureus parE conferring resistance to fluoroquinolones ARO:3003315 Point mutation in Staphylococcus aureus parE resulting in fluoroquinolones resistance. PMID:21996946 Saur_parE_FLO Point mutation in Escherichia coli parE resulting in fluoroquinolones resistance. Ecol_parE_FLO antibiotic_resistance ARO:3003316 Escherichia coli parE conferring resistance to fluoroquinolones ARO:3003316 Point mutation in Escherichia coli parE resulting in fluoroquinolones resistance. PMID:25631675 Ecol_parE_FLO Point mutation in Salmonella serovars parE resulting in fluoroquinolones resistance. Sser_parE_FLO antibiotic_resistance ARO:3003317 Salmonella serovars parE conferring resistance to fluoroquinolones ARO:3003317 Point mutation in Salmonella serovars parE resulting in fluoroquinolones resistance. PMID:19104017 Sser_parE_FLO Intrinsically aminocoumarin-resistant parY variant found in Streptomyces, an aminocoumarin-producing genus. Sris_parY_AMU antibiotic_resistance ARO:3003318 Streptomyces rishiriensis parY mutant conferring resistance to aminocoumarin ARO:3003318 Intrinsically aminocoumarin-resistant parY variant found in Streptomyces, an aminocoumarin-producing genus. PMID:14993313 Sris_parY_AMU Point mutations that occur within Staphylococcus aureus mprF gene resulting in resistance to daptomycin. Saur_mprF_DAP antibiotic_resistance ARO:3003319 Staphylococcus aureus mprF with mutation conferring resistance to daptomycin ARO:3003319 Point mutations that occur within Staphylococcus aureus mprF gene resulting in resistance to daptomycin. PMID:16723576 PMID:20498310 PMID:22238576 PMID:26055370 Saur_mprF_DAP Point mutations that occur within Staphylococcus aureus pgsA gene resulting in resistance to daptomycin. Saur_pgsA_DAP antibiotic_resistance ARO:3003323 Staphylococcus aureus pgsA mutations conferring resistance to daptomycin ARO:3003323 Point mutations that occur within Staphylococcus aureus pgsA gene resulting in resistance to daptomycin. PMID:22238576 Saur_pgsA_DAP MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. Additionally, large-scale mutations causing loss of function of the gene result in increased susceptibility to daptomycin. Bsub_mprF antibiotic_resistance ARO:3003324 Bacillus subtilis mprF ARO:3003324 MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. Additionally, large-scale mutations causing loss of function of the gene result in increased susceptibility to daptomycin. PMID:19164152 PMID:19915718 PMID:21709092 Bsub_mprF Point mutations that occur within Mycobacterium tuberculosis variant bovis embB gene resulting in resistance to ethambutol. Mbov_embB_EMB Rv3795 antibiotic_resistance ARO:3003325 Mycobacterium tuberculosis variant bovis embB with mutation conferring resistance to ethambutol ARO:3003325 Point mutations that occur within Mycobacterium tuberculosis variant bovis embB gene resulting in resistance to ethambutol. PMID:25554388 Mbov_embB_EMB Point mutations that occur within Mycobacterium tuberculosis embB gene resulting in resistance to ethambutol. Mtub_embB_EMB Rv3795 antibiotic_resistance ARO:3003326 Mycobacterium tuberculosis embB mutant conferring resistance to ethambutol ARO:3003326 Point mutations that occur within Mycobacterium tuberculosis embB gene resulting in resistance to ethambutol. ISBN:978-92-4-008241-0 PMID:10639358 PMID:11854934 PMID:16377878 PMID:16641474 PMID:16972132 PMID:17360809 PMID:21300839 PMID:21778195 PMID:24392447 PMID:30337678 PMID:35944069 PMID:9142129 PMID:9257740 Mtub_embB_EMB Point mutations in Mycobacterium tuberculosis embC that result in lower affinity between ethambutol and EmbC, resulting in resistance. Mtub_embC_EMB Rv3793 antibiotic_resistance ARO:3003327 Mycobacterium tuberculosis embC mutant conferring resistance to ethambutol ARO:3003327 Point mutations in Mycobacterium tuberculosis embC that result in lower affinity between ethambutol and EmbC, resulting in resistance. PMID:10639358 PMID:16972132 PMID:19010731 PMID:19112008 PMID:20427375 PMID:23995136 PMID:26417605 PMID:30337678 Mtub_embC_EMB Point mutations in the 3' minor, 3' major, and central domains in the rrsC 16S rRNA gene of Escherichia coli can confer resistance to kasugamicin. Ecol_16rrsC_KAS antibiotic_resistance ARO:3003333 Escherichia coli 16S rRNA (rrsC) mutation conferring resistance to kasugamicin ARO:3003333 Point mutations in the 3' minor, 3' major, and central domains in the rrsC 16S rRNA gene of Escherichia coli can confer resistance to kasugamicin. PMID:10512710 Ecol_16rrsC_KAS Sequence variants of elongation factor Tu that confer resistance to different classes of antibiotics. antibiotic_resistance ARO:3003356 Antibiotic resistant EF-Tu ARO:3003356 Sequence variants of Clostridioides difficile elongation factor Tu that confer resistance to elfamycin antibiotics. Cdif_EFTu_ELF antibiotic_resistance ARO:3003357 Clostridioides difficile EF-Tu mutants conferring resistance to elfamycin ARO:3003357 Sequence variants of Clostridioides difficile elongation factor Tu that confer resistance to elfamycin antibiotics. PMID:22644023 Cdif_EFTu_ELF Sequence variants of Escherichia coli elongation factor Tu that confer resistance to elfamycin antibiotics. antibiotic_resistance ARO:3003358 Escherichia coli EF-Tu mutants conferring resistance to elfamycin ARO:3003358 Sequence variants of Streptomyces cinnamoneus elongation factor Tu that confer resistance to elfamycin antibiotics. Scin_EFTu_ELF antibiotic_resistance ARO:3003359 Streptomyces cinnamoneus EF-Tu mutants conferring resistance to elfamycin ARO:3003359 Sequence variants of Streptomyces cinnamoneus elongation factor Tu that confer resistance to elfamycin antibiotics. PMID:9043138 Scin_EFTu_ELF Sequence variants of Planobispora rosea elongation factor Tu that confer resistance to elfamycin antibiotics. antibiotic_resistance ARO:3003360 Planobispora rosea EF-Tu mutants conferring resistance to elfamycin ARO:3003360 Sequence variants of Planobispora rosea elongation factor Tu that confer resistance to elfamycin antibiotics. PMID:8899707 Sequence variants of Planobispora rosea elongation factor Tu that confer resistance to inhibitor GE2270A. Pros_EFTu_GE2A antibiotic_resistance ARO:3003361 Planobispora rosea EF-Tu mutants conferring resistance to inhibitor GE2270A ARO:3003361 Sequence variants of Planobispora rosea elongation factor Tu that confer resistance to inhibitor GE2270A. PMID:12370016 PMID:8899707 Pros_EFTu_GE2A Sequence variants of Escherichia coli elongation factor Tu that confer resistance to kirromycin. Ecol_EFTu_KIR antibiotic_resistance ARO:3003368 Escherichia coli EF-Tu mutants conferring resistance to kirromycin ARO:3003368 Sequence variants of Escherichia coli elongation factor Tu that confer resistance to kirromycin. PMID:12370016 PMID:1552908 PMID:7525272 Ecol_EFTu_KIR Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Pulvomycin. Ecol_EFTu_PLV antibiotic_resistance ARO:3003369 Escherichia coli EF-Tu mutants conferring resistance to Pulvomycin ARO:3003369 Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Pulvomycin. PMID:7957075 Ecol_EFTu_PLV Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Enacyloxin IIa. Ecol_EFTu_ENC antibiotic_resistance ARO:3003370 Escherichia coli EF-Tu mutants conferring resistance to Enacyloxin IIa ARO:3003370 Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Enacyloxin IIa. PMID:10610785 Ecol_EFTu_ENC Point mutations in the 3' major domain of the rrsH 16S rRNA gene of Escherichia coli can confer resistance to spectinomycin. Ecol_16rrsH_SPT antibiotic_resistance ARO:3003372 Escherichia coli 16S rRNA (rrsH) mutation conferring resistance to spectinomycin ARO:3003372 Point mutations in the 3' major domain of the rrsH 16S rRNA gene of Escherichia coli can confer resistance to spectinomycin. PMID:6330677 Ecol_16rrsH_SPT AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance. Kpne_acrR_MULT antibiotic_resistance ARO:3003373 Klebsiella pneumoniae acrR with mutation conferring multidrug antibiotic resistance ARO:3003373 AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance. PMID:12936981 PMID:25182649 Kpne_acrR_MULT AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance. Kaer_acrR_MULT antibiotic_resistance ARO:3003374 Enterobacter aerogenes acrR with mutation conferring multidrug antibiotic resistance ARO:3003374 AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance. PMID:12121946 Kaer_acrR_MULT Point mutations in the 3' major domain of the rrsB 16S rRNA gene of Escherichia coli can confer resistance to spectinomycin. Ecol_16rrsB_SPT antibiotic_resistance ARO:3003376 Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to spectinomycin ARO:3003376 Point mutations in the 3' major domain of the rrsB 16S rRNA gene of Escherichia coli can confer resistance to spectinomycin. PMID:2447957 PMID:7885842 PMID:8127669 Ecol_16rrsB_SPT Point mutations in the 3' major domain of helix 35, in the rrnB gene operon for 16S rRNA of Escherichia coli can confer resistance to spectinomycin. Ecol_16S_SPT antibiotic_resistance ARO:3003377 Escherichia coli 16S rRNA (rrnB) mutation conferring resistance to spectinomycin ARO:3003377 Point mutations in the 3' major domain of helix 35, in the rrnB gene operon for 16S rRNA of Escherichia coli can confer resistance to spectinomycin. PMID:16269538 Ecol_16S_SPT MarR is a repressor of the mar operon marRAB, thus regulating the expression of marA, the activator of multidrug efflux pump AcrAB. Ecol_MarR_MULT antibiotic_resistance ARO:3003378 Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline ARO:3003378 MarR is a repressor of the mar operon marRAB, thus regulating the expression of marA, the activator of multidrug efflux pump AcrAB. PMID:10760140 PMID:11302826 PMID:12027588 PMID:8550435 PMID:8807064 PMID:9333027 PMID:9687412 Ecol_MarR_MULT RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA. Sent_ramR antibiotic_resistance ARO:3003379 Salmonella enterica ramR mutants ARO:3003379 RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA. PMID:18443112 PMID:19104017 PMID:19270312 PMID:19778917 Sent_ramR RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA. Kpne_ramR antibiotic_resistance ARO:3003380 Klebsiella pneumoniae ramR mutants ARO:3003380 RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA. PMID:25182649 Kpne_ramR SoxR is a sensory protein that upregulates soxS expression in the presence of redox-cycling drugs. This stress response leads to the expression many multidrug efflux pumps. Ecol_soxR_MULT antibiotic_resistance ARO:3003381 Escherichia coli soxR with mutation conferring antibiotic resistance ARO:3003381 SoxR is a sensory protein that upregulates soxS expression in the presence of redox-cycling drugs. This stress response leads to the expression many multidrug efflux pumps. PMID:11302826 PMID:15980345 PMID:21226770 Ecol_soxR_MULT SoxR is a sensory protein that upregulates soxS expression in the presence of redox-cycling drugs. This stress response leads to the expression of many multidrug efflux pumps. Sent_soxR_MULT antibiotic_resistance ARO:3003382 Salmonella enterica soxR with mutation conferring antibiotic resistance ARO:3003382 SoxR is a sensory protein that upregulates soxS expression in the presence of redox-cycling drugs. This stress response leads to the expression of many multidrug efflux pumps. PMID:11302826 PMID:19104017 Sent_soxR_MULT SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability. Sent_soxS_MULT antibiotic_resistance ARO:3003383 Salmonella serovars soxS with mutation conferring antibiotic resistance ARO:3003383 SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability. PMID:19104017 Sent_soxS_MULT Mutant forms of the porin Omp36 result in reduced permeability to antibiotics. Kaer_Omp36 antibiotic_resistance ARO:3003385 Klebsiella aerogenes Omp36 ARO:3003385 Mutant forms of the porin Omp36 result in reduced permeability to antibiotics. PMID:15081418 Kaer_Omp36 Point mutations in Escherichia coli dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance. Ecol_folP_SLF antibiotic_resistance ARO:3003386 Escherichia coli folP with mutation conferring resistance to sulfonamides ARO:3003386 Point mutations in Escherichia coli dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance. PMID:9449266 Ecol_folP_SLF Point mutations in Streptococcus pyogenes dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance. Spyo_folP_SLF antibiotic_resistance ARO:3003387 Streptococcus pyogenes folP with mutation conferring resistance to sulfonamides ARO:3003387 Point mutations in Streptococcus pyogenes dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance. PMID:9593127 Spyo_folP_SLF Dapsone inhibits bacterial synthesis of dihydrofolic acid by competing with with para-aminobenzoate for the active site of dihydropteroate synthetase. Thus acts as a competitive inhibitor of folP. Point mutation within the folP gene results in lowered affinity of dapsone for folP. antibiotic_resistance ARO:3003388 dapsone resistant dihydropteroate synthase folP ARO:3003388 Dapsone inhibits bacterial synthesis of dihydrofolic acid by competing with with para-aminobenzoate for the active site of dihydropteroate synthetase. Point mutation within the Mycobacterium leprae folP gene results in lowered affinity of dapsone for folP. Mlep_folP_DAO antibiotic_resistance ARO:3003389 Mycobacterium leprae folP with mutation conferring resistance to dapsone ARO:3003389 Dapsone inhibits bacterial synthesis of dihydrofolic acid by competing with with para-aminobenzoate for the active site of dihydropteroate synthetase. Point mutation within the Mycobacterium leprae folP gene results in lowered affinity of dapsone for folP. PMID:11709358 PMID:15603834 PMID:21115799 Mlep_folP_DAO The Escherichia coli ompF (oprF) is a nonspecific porin channel involved in the membrane translocation of small hydrophilic molecules, including and especially beta-lactam antibiotics. Mutations in ompF can decrease diffusion of antibiotics across the cellular membrane, thereby decreasing overall susceptibility through absence of porin function. Ecol_ompF_BLA antibiotic_resistance ARO:3003390 Escherichia coli ompF with mutation conferring resistance to beta-lactam antibiotics ARO:3003390 The Escherichia coli ompF (oprF) is a nonspecific porin channel involved in the membrane translocation of small hydrophilic molecules, including and especially beta-lactam antibiotics. Mutations in ompF can decrease diffusion of antibiotics across the cellular membrane, thereby decreasing overall susceptibility through absence of porin function. PMID:10639355 Ecol_ompF_BLA katG is a catalase-peroxidase that catalyzes the activation of isoniazid. Isoniazid inhibits mycolic acid synthesis, which prevents cell wall synthesis in mycobacteria. Mutations in katG results in inability to activate isoniazid. Over 280 different mutations have been documented in PubMed for katG, with mutations to Ser315 being the most prevalent. Mtub_katG_INH Rv1908c antibiotic_resistance ARO:3003392 Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid ARO:3003392 katG is a catalase-peroxidase that catalyzes the activation of isoniazid. Isoniazid inhibits mycolic acid synthesis, which prevents cell wall synthesis in mycobacteria. Mutations in katG results in inability to activate isoniazid. Over 280 different mutations have been documented in PubMed for katG, with mutations to Ser315 being the most prevalent. ISBN:978-92-4-008241-0 PMID:10645439 PMID:14638486 PMID:16870753 PMID:18508939 PMID:19520719 PMID:20054829 PMID:20211896 PMID:21330112 PMID:22808802 PMID:23744165 PMID:24184004 PMID:24468786 PMID:24626681 PMID:25093512 PMID:26092854 PMID:26157154 PMID:26251830 PMID:28904673 PMID:30337678 PMID:30583053 PMID:31100498 PMID:34642828 PMID:35944069 PMID:36635309 PMID:7798673 PMID:8585728 Mtub_katG_INH inhA is a enoyl-acyl carrier reductase used in lipid metabolism and farry acid biosynthesis. It is inhibited by isoniazid. mutations in the promoter region or multiple copies of the inhA shows marked resistance to isoniazid mediated inhibition of mycolic acid biosynthesis. Mtub_inhA_INH Rv1484 antibiotic_resistance ARO:3003393 Mycobacterium tuberculosis inhA mutations conferring resistance to isoniazid ARO:3003393 inhA is a enoyl-acyl carrier reductase used in lipid metabolism and farry acid biosynthesis. It is inhibited by isoniazid. mutations in the promoter region or multiple copies of the inhA shows marked resistance to isoniazid mediated inhibition of mycolic acid biosynthesis. ISBN:978-92-4-008241-0 PMID:14638486 PMID:16495272 PMID:16870753 PMID:21300839 PMID:22808802 PMID:23539241 PMID:30337678 PMID:30583053 PMID:35944069 PMID:7637495 PMID:8284673 PMID:9728546 Mtub_inhA_INH pncA is a pyrazinamidase/nicotinamidase. It catalyzes the activation of pyrazinamide. Some mutation within pncA are associated with loss of enzyme activity, resulting in pyrazinamide resistance. Mtub_pncA_PZA Rv2043c antibiotic_resistance ARO:3003394 Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide ARO:3003394 pncA is a pyrazinamidase/nicotinamidase. It catalyzes the activation of pyrazinamide. Some mutation within pncA are associated with loss of enzyme activity, resulting in pyrazinamide resistance. ISBN:978-92-4-008241-0 PMID:10390238 PMID:10390239 PMID:10471589 PMID:10681313 PMID:10813147 PMID:11083630 PMID:11158123 PMID:11429043 PMID:11641519 PMID:17360809 PMID:17596354 PMID:19234602 PMID:21300839 PMID:25336456 PMID:30337678 PMID:31910878 PMID:35944069 PMID:36209317 PMID:9055989 PMID:9056006 PMID:9692180 Mtub_pncA_PZA Ribosomal protein S12 stabilizes the highly conserved pseudoknot structure formed by 16S rRNA. Amino acid substitutions in RpsL affect the higher-order structure of 16S rRNA and confer streptomycin resistance by disrupting interactions between 16S rRNA and streptomycin. Mtub_rpsL_STR Rv0682 antibiotic_resistance ARO:3003395 Mycobacterium tuberculosis rpsL mutations conferring resistance to Streptomycin ARO:3003395 Ribosomal protein S12 stabilizes the highly conserved pseudoknot structure formed by 16S rRNA. Amino acid substitutions in RpsL affect the higher-order structure of 16S rRNA and confer streptomycin resistance by disrupting interactions between 16S rRNA and streptomycin. ISBN:978-92-4-008241-0 PMID:15305490 PMID:17238915 PMID:22943573 PMID:30337678 PMID:35944069 PMID:7934937 PMID:7968530 PMID:8849220 Mtub_rpsL_STR Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to gentamicin C. Ecol_16S_GENC antibiotic_resistance ARO:3003396 Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to gentamicin C ARO:3003396 Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to gentamicin C. PMID:11502507 Ecol_16S_GENC Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to G418. Ecol_16S_G418 antibiotic_resistance ARO:3003397 Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to G418 ARO:3003397 Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to G418. PMID:11502507 Ecol_16S_G418 Undecaprenyl phosphate is a universal lipid carrier of glycan biosynthetic intermediates for carbohydrate polymers that are exported to the bacterial cell envelope. Antibiotics that targets this compound or proteins associated with the production of this compound leads to cell death. antibiotic_resistance ARO:3003398 undecaprenyl pyrophosphate related proteins ARO:3003398 Undecaprenyl phosphate is a universal lipid carrier of glycan biosynthetic intermediates for carbohydrate polymers that are exported to the bacterial cell envelope. Antibiotics that targets this compound or proteins associated with the production of this compound leads to cell death. PMID:17660416 Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to kanamycin A. Ecol_16rrsB_KAN antibiotic_resistance ARO:3003399 Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to kanamycin A ARO:3003399 Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to kanamycin A. PMID:11502507 Ecol_16rrsB_KAN A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium laprae. Its mechanism of action involves inhibition of folic acid synthesis in susceptible organisms. antibiotic_resistance ARO:3003401 sulfone antibiotic ARO:3003401 Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to neomycin. Ecol_16rrsB_NEO antibiotic_resistance ARO:3003402 Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to neomycin ARO:3003402 Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to neomycin. PMID:11502507 Ecol_16rrsB_NEO Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to paromomycin. Ecol_16rrsB_PAR antibiotic_resistance ARO:3003403 Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to paromomycin ARO:3003403 Point mutations in the 3' minor domain of helix 44, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to paromomycin. PMID:11502507 Ecol_16rrsB_PAR Point mutations in the 5' domain of helix 18, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to streptomycin. Ecol_16rrsB_STR antibiotic_resistance ARO:3003405 Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to streptomycin ARO:3003405 Point mutations in the 5' domain of helix 18, in the rrsB 16S rRNA gene of Escherichia coli can confer resistance to streptomycin. PMID:3054810 Ecol_16rrsB_STR Point mutations in the 5' domain of helix 18, in the rrnB 16S rRNA gene of Escherichia coli can confer resistance to streptomycin. Ecol_16S_STR antibiotic_resistance ARO:3003406 Escherichia coli 16S rRNA (rrnB) mutation conferring resistance to streptomycin ARO:3003406 Point mutations in the 5' domain of helix 18, in the rrnB 16S rRNA gene of Escherichia coli can confer resistance to streptomycin. PMID:16269538 Ecol_16S_STR Point mutations in the 3' minor domain of the rrnB 16S rRNA gene of Escherichia coli can confer resistance to tobramycin. Ecol_16rrsB_TOB antibiotic_resistance ARO:3003408 Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to tobramycin ARO:3003408 Point mutations in the 3' minor domain of the rrnB 16S rRNA gene of Escherichia coli can confer resistance to tobramycin. PMID:11502507 Ecol_16rrsB_TOB Point mutations in the 3' major domain of the rrsB 16S rRNA gene of Escherichia coli can confer resistance to tetracycline. Ecol_16rrsB_TET antibiotic_resistance ARO:3003410 Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to tetracycline ARO:3003410 Point mutations in the 3' major domain of the rrsB 16S rRNA gene of Escherichia coli can confer resistance to tetracycline. PMID:9661007 Ecol_16rrsB_TET Point mutations in the 3' major domain of the rrnB 16S rRNA gene of Escherichia coli can confer resistance to tetracycline. Ecol_16S_TET antibiotic_resistance ARO:3003411 Escherichia coli 16S rRNA (rrnB) mutation conferring resistance to tetracycline ARO:3003411 Point mutations in the 3' major domain of the rrnB 16S rRNA gene of Escherichia coli can confer resistance to tetracycline. PMID:16269538 Ecol_16S_TET Dapsone is a sulfone in which it inhibits folic acid synthesis, such as the dihydropteroate synthase. CAS:80-08-0 ChEBI:4325 ChEMBL:CHEMBL1043 PubChem:2955 diaminodiphenyl sulfone antibiotic_resistance ARO:3003412 dapsone ARO:3003412 Pyrazinamide is an antimycobacterial. It is highly specific and active only against Mycobacterium tuberculosis. This compound is a prodrug and needs to be activated inside the cell. It interferes with the bacterium's ability to synthesize new fatty acids, causing cell death. CAS:98-96-4 ChEMBL:CHEMBL614 PubChem:1046 antibiotic_resistance ARO:3003413 pyrazinamide ARO:3003413 Pyrazinamide is an antimycobacterial. It is highly specific and active only against Mycobacterium tuberculosis. This compound is a prodrug and needs to be activated inside the cell. It interferes with the bacterium's ability to synthesize new fatty acids, causing cell death. PMID:26104205 LFF571 is a novel semi-synthetic thiopeptide antibiotic derived from GE2270. It has been shown to possess potent in vitro and in vivo activity against Gram-positive bacteria. It is hypothesized that it a translation inhibitor leading to cell death. ChEMBL:CHEMBL2063705 PubChem:42638236 antibiotic_resistance ARO:3003414 LFF571 ARO:3003414 LFF571 is a novel semi-synthetic thiopeptide antibiotic derived from GE2270. It has been shown to possess potent in vitro and in vivo activity against Gram-positive bacteria. It is hypothesized that it a translation inhibitor leading to cell death. PMID:22644023 Point mutations in dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance. antibiotic_resistance ARO:3003415 sulfonamide resistant dihydropteroate synthase folP ARO:3003415 Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. It is a catalase-peroxidases that catalyzes the activation of isoniazid. Mutations that arises within this protein cause changes that results in the inability for katG to activate antibiotics, conferring resistance. catalase-peroxidases antibiotic_resistance ARO:3003416 isoniazid resistant katG ARO:3003416 inhA is a enoyl-acyl carrier reductase used in lipid metabolism and fatty acid biosynthesis. It is inhibited by isoniazid. Mutations in the promoter region or multiple copies of the inhA shows marked resistance to isoniazid mediated inhibition of mycolic acid biosynthesis. enoyl-acyl carrier reductase antibiotic_resistance ARO:3003417 antibiotic resistant inhA ARO:3003417 inhA is a enoyl-acyl carrier reductase used in lipid metabolism and fatty acid biosynthesis. It is inhibited by isoniazid. Mutations in the promoter region or multiple copies of the inhA shows marked resistance to isoniazid mediated inhibition of mycolic acid biosynthesis. PMID:8284673 pncA is a pyrazinamidase/nicotinamidase. It catalyzes the activation of pyrazinamide to pyrazinoic acid. Mutations arise within the pncA gene that caused the loss of pyrazinamidase activity is the major mechanism of antibiotic resistance. nicotinamidase antibiotic_resistance ARO:3003418 Pyrazinamide resistant pncA ARO:3003418 pncA is a pyrazinamidase/nicotinamidase. It catalyzes the activation of pyrazinamide to pyrazinoic acid. Mutations arise within the pncA gene that caused the loss of pyrazinamidase activity is the major mechanism of antibiotic resistance. PMID:9055989 Ribosomal protein S12 stabilizes the highly conserved pseudoknot structure formed by 16S rRNA. Amino acid substitutions in RpsL affect the higher-order structure of 16S rRNA and confer antibiotic resistance. Ribosomal protein S12 antibiotic_resistance ARO:3003419 antibiotic-resistant rpsL ARO:3003419 pgsA or phosphatidylglycerophosphate synthetase is an integral membrane protein involved in phospholipid biosynthesis. It is a CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase. phosphatidylglycerophosphate synthetase antibiotic_resistance ARO:3003420 antibiotic resistant pgsA ARO:3003420 Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms (bacteriocins). Phosphatidylglycerol lysyltransferase antibiotic_resistance ARO:3003421 antibiotic resistant mprF ARO:3003421 Arabinofuranosyltransferase is involved in the biosynthesis of the arabinogalactan region of the mAGP complex, an essential component of the mycobacterial cell wall. antibiotic_resistance ARO:3003422 antibiotic resistant aftA ARO:3003422 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. antibiotic_resistance ARO:3003425 antibiotic resistant dihydrofolate reductase ARO:3003425 inhA is a enoyl-acyl carrier reductase used in lipid metabolism and fatty acid biosynthesis. antibiotic_resistance ARO:3003426 antibiotic sensitive inhA ARO:3003426 Porin proteins permeable to antibiotics. antibiotic_resistance ARO:3003428 porin proteins permeable to antibiotics ARO:3003428 RNA polymerase is a multisubunit enzyme that is necessary for transcription. The beta-prime subunit of RNA polymerase forms the active center of the enzyme and template/transcript binding sites. This enzyme can be inactivated by antibiotics leading to cell death. antibiotic_resistance ARO:3003429 antibiotic sensitive beta-prime subunit of RNA polymerase (rpoC) ARO:3003429 ParE is a subunit of topoisomerase IV, necessary for cell survival. Point mutations in ParE prevent fluoroquinolones from inhibiting DNA synthesis, thus conferring resistance. antibiotic_resistance ARO:3003430 fluoroquinolone sensitive parE ARO:3003430 Ribosomal protein S12 stabilizes the highly conserved pseudoknot structure formed by 16S rRNA. It is targeted and inhibited by streptomycin. antibiotic_resistance ARO:3003431 antibiotic sensitive Ribosomal protein S12 (rpsL) ARO:3003431 Point mutations in the 3' domain of 16S rRNA of Mycobacterium tuberculosis can confer resistance to kanamycin. Mtub_16S_KAN rrs antibiotic_resistance ARO:3003436 Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to kanamycin ARO:3003436 Point mutations in the 3' domain of 16S rRNA of Mycobacterium tuberculosis can confer resistance to kanamycin. ISBN:978-92-4-008241-0 PMID:30337678 PMID:35944069 PMID:9244267 PMID:9574680 Mtub_16S_KAN Peptide antibiotics inhibit protein synthesis. Resistance to viomycin can be caused by an altered RNA molecule in the 16S ribosomal subunit. Mtub_16S_VIO rrs antibiotic_resistance ARO:3003437 Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to viomycin ARO:3003437 Peptide antibiotics inhibit protein synthesis. Resistance to viomycin can be caused by an altered RNA molecule in the 16S ribosomal subunit. PMID:9244267 Mtub_16S_VIO Sequence variants of Enterococcus faecium elongation factor Tu that confer resistance to GE2270A. Efac_EFTu_GE2A antibiotic_resistance ARO:3003438 Enterococcus faecium EF-Tu mutants conferring resistance to GE2270A ARO:3003438 Sequence variants of Enterococcus faecium elongation factor Tu that confer resistance to GE2270A. PMID:7989561 Efac_EFTu_GE2A The switch region is a structural element that mediates conformational changes and contacts required for RNAP to load DNA into the RNAP active-center cleft during transcription initiation. The switch region is located at the base of the RNAP clamp and serves as the hinge that mediates opening of the RNAP clamp to load DNA into the RNAP active-center cleft and mediates closing of the RNAP clamp to retain DNA in the RNAP active-center cleft. antibiotic_resistance ARO:3003439 antibiotic sensitive RNA polymerase switch region ARO:3003439 The switch region is a structural element that mediates conformational changes and contacts required for RNAP to load DNA into the RNAP active-center cleft during transcription initiation. The switch region is located at the base of the RNAP clamp and serves as the hinge that mediates opening of the RNAP clamp to load DNA into the RNAP active-center cleft and mediates closing of the RNAP clamp to retain DNA in the RNAP active-center cleft. PMID:21862392 A foreign PBP2 acquired by lateral gene transfer that able to perform peptidoglycan synthesis in the presence of beta-lactams. PBP2B mecB antibiotic_resistance ARO:3003440 mecB ARO:3003440 A foreign PBP2 acquired by lateral gene transfer that able to perform peptidoglycan synthesis in the presence of beta-lactams. PMID:24302651 mecB CfrA is a chloramphenicol-florfenicol resistance gene and methyltransferase enzyme. Methylation of position 8 of A2503 in 23S rRNA confers resistance to chloramphenicol antibiotics first identified by Schwarz 2000 as cfr from Mammaliicoccus sciuri. Additional Oxazolidinone resistance mediated by the cfr gene in a human isolated was first reported from Colombia in linezolid- and methicillin-resistant Staphylococcus aureus. cfr cfr(A) cfrA antibiotic_resistance ARO:3003441 cfrA ARO:3003441 CfrA is a chloramphenicol-florfenicol resistance gene and methyltransferase enzyme. Methylation of position 8 of A2503 in 23S rRNA confers resistance to chloramphenicol antibiotics first identified by Schwarz 2000 as cfr from Mammaliicoccus sciuri. Additional Oxazolidinone resistance mediated by the cfr gene in a human isolated was first reported from Colombia in linezolid- and methicillin-resistant Staphylococcus aureus. PMID:10952608 PMID:15700955 PMID:17145796 PMID:18174304 PMID:28663118 cfrA tlyA encodes for hemolysin. It Catalyzes the 2'-O-methylation at nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA. Mutation that arise within this gene reduces the binding affinity of aminoglycosides to rRNA. antibiotic_resistance ARO:3003443 Antibiotic resistant tlyA ARO:3003443 tlyA encodes for hemolysin. It Catalyzes the 2'-O-methylation at nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA. Mutation that arise within this gene reduces the binding affinity of aminoglycosides to rRNA. PMID:15673735 Specific mutations that arise in Mycobacterium tuberculosis tlyA resulting in aminoglycosides resistance. Mtub_tlyA_AMG Rv1694 antibiotic_resistance ARO:3003445 Mycobacterium tuberculosis tlyA mutations conferring resistance to aminoglycosides ARO:3003445 Specific mutations that arise in Mycobacterium tuberculosis tlyA resulting in aminoglycosides resistance. PMID:15673735 PMID:30337678 Mtub_tlyA_AMG iniA, an isoniazid-induced protein, is part of the iniBAC operon that participates in the development of tolerance to both isoniazid and ethambutol. May function through a MDR-pump like mechanism, although it does not appear to directly transport isoniazid from the cell. antibiotic_resistance ARO:3003446 antibiotic resistant iniA ARO:3003446 iniA, an isoniazid-induced protein, is part of the iniBAC operon that participates in the development of tolerance to both isoniazid and ethambutol. May function through a MDR-pump like mechanism, although it does not appear to directly transport isoniazid from the cell. PMID:15752203 Mutations that occurs on the iniA genes resulting in the resistance to ethambutol. antibiotic_resistance ARO:3003447 ethambutol resistant iniA ARO:3003447 Specific mutations in Mycobacterium tuberculosis iniA resulting in resistance to ethambutol. Mtub_iniA_EMB Rv0342 antibiotic_resistance ARO:3003448 Mycobacterium tuberculosis iniA mutant conferring resistance to ethambutol ARO:3003448 Specific mutations in Mycobacterium tuberculosis iniA resulting in resistance to ethambutol. PMID:10639358 PMID:12654653 Mtub_iniA_EMB iniC, an isoniazid-induced protein, is part of the iniBAC operon that participates in the development of tolerance to both isoniazid and ethambutol. May function through a MDR-pump like mechanism, although it does not appear to directly transport isoniazid from the cell. antibiotic_resistance ARO:3003449 Antibiotic resistant iniC ARO:3003449 iniC, an isoniazid-induced protein, is part of the iniBAC operon that participates in the development of tolerance to both isoniazid and ethambutol. May function through a MDR-pump like mechanism, although it does not appear to directly transport isoniazid from the cell. PMID:15752203 Mutations that occurs on the iniC genes resulting in the resistance to ethambutol. antibiotic_resistance ARO:3003450 Ethambutol resistant iniC ARO:3003450 Specific mutations that occurs on Mycobacterium tuberculosis iniC causing it to be ethambutol resistant. Mtub_iniC_EMB Rv0343 antibiotic_resistance ARO:3003451 Mycobacterium tuberculosis iniC mutant conferring resistance to ethambutol ARO:3003451 Specific mutations that occurs on Mycobacterium tuberculosis iniC causing it to be ethambutol resistant. PMID:10639358 PMID:12654653 PMID:16272473 Mtub_iniC_EMB Mutations that occurs on the embA genes resulting in the resistance to ethambutol. antibiotic_resistance ARO:3003452 ethambutol resistant embA ARO:3003452 Specific mutations that occurs on Mycobacterium tuberculosis embA leading to the lowered affinity of ethambutol to embA. Mtub_embA_EMB Rv3794 antibiotic_resistance ARO:3003453 Mycobacterium tuberculosis embA mutant conferring resistance to ethambutol ARO:3003453 Specific mutations that occurs on Mycobacterium tuberculosis embA leading to the lowered affinity of ethambutol to embA. PMID:10639358 PMID:30337678 PMID:35944069 Mtub_embA_EMB Mutations that occurs on the embR genes resulting in the resistance to ethambutol. antibiotic_resistance ARO:3003454 ethambutol resistant embR ARO:3003454 Point mutation in the M.tuberculosis embR results in increased resistance to ethambutol. Mtub_embR_EMB Rv1267c antibiotic_resistance ARO:3003455 Mycobacterium tuberculosis embR mutant conferring resistance to ethambutol ARO:3003455 Point mutation in the M.tuberculosis embR results in increased resistance to ethambutol. PMID:10639358 PMID:30337678 Mtub_embR_EMB Monooxygenase able to convert a wide range of ketones to the corresponding esters or lactones via a Baeyer-Villiger oxidation reaction. It is responsible for the activation of several thiocarbamide-containing pro-drugs into cytotoxic species. FAD-containing monooxygenase antibiotic_resistance ARO:3003456 antibiotic resistant ethA ARO:3003456 Monooxygenase able to convert a wide range of ketones to the corresponding esters or lactones via a Baeyer-Villiger oxidation reaction. It is responsible for the activation of several thiocarbamide-containing pro-drugs into cytotoxic species. PMID:10869356 Mutations that occurs on the ethA genes resulting in the inability to catalyzes the oxidation of ethionamide (ETH) to the corresponding sulfoxide (the active drug). antibiotic_resistance ARO:3003457 ethionamide resistant ethA ARO:3003457 Mycobacterium tuberculosis ethA (Rv3854c) is a mono-oxygenase enzyme which activates the antibiotic ethionamide in vivo. Mutations in ethA confer resistance to ethionamide by modulating the activation and activity of the ethionamide prodrug. Mtub_ethA_ETO Rv3854c antibiotic_resistance ARO:3003458 Mycobacterium tuberculosis ethA with mutation conferring resistance to ethionamide ARO:3003458 Mycobacterium tuberculosis ethA (Rv3854c) is a mono-oxygenase enzyme which activates the antibiotic ethionamide in vivo. Mutations in ethA confer resistance to ethionamide by modulating the activation and activity of the ethionamide prodrug. ISBN:978-92-4-008241-0 PMID:10944230 PMID:14638486 PMID:28993337 PMID:30337678 Mtub_ethA_ETO Point mutation in Mycobacterium tuberculosis gyrB resulting in fluoroquinolone resistance. Mtub_gyrB_FLO Rv0005 antibiotic_resistance ARO:3003459 Mycobacterium tuberculosis gyrB mutant conferring resistance to fluoroquinolones ARO:3003459 Point mutation in Mycobacterium tuberculosis gyrB resulting in fluoroquinolone resistance. ISBN:978-92-4-008241-0 PMID:16377674 PMID:22761889 PMID:30337678 PMID:35944069 Mtub_gyrB_FLO ndh is a NADH oxidase. It participates in antibiotic resistance by diminishing NADH oxidation and consequently causes an increase in NADH concentration and depletion of NAD+. This alteration of the NADH/NAD+ ratio prevents the peroxidation reactions required for the activation of INH, as well as the displacement of the NADH-isonicotinic acyl complex from InhA enzyme binding site. antibiotic_resistance ARO:3003460 antibiotic resistant ndh ARO:3003460 ndh is a NADH oxidase. It participates in antibiotic resistance by diminishing NADH oxidation and consequently causes an increase in NADH concentration and depletion of NAD+. This alteration of the NADH/NAD+ ratio prevents the peroxidation reactions required for the activation of INH, as well as the displacement of the NADH-isonicotinic acyl complex from InhA enzyme binding site. PMID:17294000 Point mutations in the Mycobacterium tuberculosis ndh gene shown clinically to confer resistance to isoniazid. Mtub_ndh_INH Rv1854c antibiotic_resistance ARO:3003461 Mycobacterium tuberculosis ndh with mutation conferring resistance to isoniazid ARO:3003461 Point mutations in the Mycobacterium tuberculosis ndh gene shown clinically to confer resistance to isoniazid. PMID:17294000 PMID:24855126 PMID:26104204 PMID:26311839 PMID:26369965 PMID:30337678 PMID:30583053 Mtub_ndh_INH kasA is a ketoacyl acyl carrier protein synthase that catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. It is involved in elongation of fatty acids intermediate in the biosynthetic pathway of mycolic acids. antibiotic_resistance ARO:3003462 antibiotic resistant kasA ARO:3003462 kasA is a ketoacyl acyl carrier protein synthase that catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. It is involved in elongation of fatty acids intermediate in the biosynthetic pathway of mycolic acids. PMID:10428945 Specific mutations on the Mycobacterium tuberculosis kasA gene resulting in lowered affinity of isoniazid, resulting in resistance. Mtub_kasA_INH Rv2245 antibiotic_resistance ARO:3003463 Mycobacterium tuberculosis kasA mutant conferring resistance to isoniazid ARO:3003463 Specific mutations on the Mycobacterium tuberculosis kasA gene resulting in lowered affinity of isoniazid, resulting in resistance. PMID:10428945 PMID:30337678 PMID:9616124 Mtub_kasA_INH Arabinosyl transferases allow for the polymerization of arabinose to form arabinan. Arabanan is required for formation of mycobacterial cell walls and arabinosyltransferases are targets of the drug ethambutol. Mutations in these genes can confer resistance to rifampicin. antibiotic_resistance ARO:3003464 rifamycin-resistant arabinosyltransferase ARO:3003464 Arabinosyl transferases allow for the polymerization of arabinose to form arabinan. Arabanan is required for formation of mycobacterial cell walls and arabinosyltransferases are targets of the drug ethambutol. Mutations in these genes can confer resistance to rifampicin. PMID:17846128 Specific mutations that occurs on Mycobacterium tuberculosis embB causing it to be rifampicin resistant. Mtub_embB_RIF Rv3795 antibiotic_resistance ARO:3003465 Mycobacterium tuberculosis embB with mutation conferring resistance to rifampicin ARO:3003465 Specific mutations that occurs on Mycobacterium tuberculosis embB causing it to be rifampicin resistant. PMID:17846128 Mtub_embB_RIF GidB is a m7G methyltransferase specific for 16S rRNA. Mutations within the gidB gene causes changes in the structure or 16s rRNA, leading to resistance to aminoglycosides. rsmG antibiotic_resistance ARO:3003466 antibiotic resistant gidB ARO:3003466 Specific mutations that occurs on Mycobacterium tuberculosis gidB causing it to be streptomycin resistant. Mtub_gidB_STR Rv3919c antibiotic_resistance ARO:3003470 Mycobacterium tuberculosis gidB mutation conferring resistance to streptomycin ARO:3003470 Specific mutations that occurs on Mycobacterium tuberculosis gidB causing it to be streptomycin resistant. ISBN:978-92-4-008241-0 PMID:17238915 PMID:18541729 PMID:21444711 PMID:21593257 PMID:30337678 PMID:31100498 PMID:31934102 PMID:32014024 Mtub_gidB_STR Wildtype embR is sensitive to antibiotics. It is an arabinosyltransferase involved in lipoarabinomannan synthesis. antibiotic_resistance ARO:3003473 Antibiotic sensitive embR ARO:3003473 Ethionamide is a second-line antitubercular agent that inhibits mycolic acid synthesis. CAS:536-33-4 ChEBI:4885 ChEMBL:CHEMBL1441 PubChem:2761171 antibiotic_resistance ARO:3003474 ethionamide ARO:3003474 ethA is a monooxygenase that is able to convert a wide range of ketones to the corresponding esters or lactones via a Baeyer-Villiger oxidation reaction. Is responsible for the activation of several thiocarbamide-containing pro-drugs into cytotoxic species. antibiotic_resistance ARO:3003475 Antibiotic sensitive ethA ARO:3003475 It Catalyzes the 2'-O-methylation at nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA. antibiotic_resistance ARO:3003476 antibiotic sensitive tlyA ARO:3003476 GidB is a m7G methyltransferase specific for 16S rRNA. rsmG antibiotic_resistance ARO:3003477 antibiotic sensitive gidB ARO:3003477 GidB is a m7G methyltransferase specific for 16S rRNA. PMID:17238915 kasA is a ketoacyl acyl carrier protein synthase that catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. It is involved in elongation of fatty acids intermediate in the biosynthetic pathway of mycolic acids. antibiotic_resistance ARO:3003478 antibiotic sensitive kasA ARO:3003478 TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites. Mutations arise within tetR results in lower affinity for tetracyclin. tetR antibiotic_resistance ARO:3003479 tetR ARO:3003479 TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites. Mutations arise within tetR results in lower affinity for tetracyclin. PMID:3062183 tetR Point mutations within the 530 loop of the 16S rRNA of Mycobacterium tuberculosis can result in resistance against streptomycin. These mutations do not directly inhibit the binding of streptomycin, but is hypothesized that they interfere with conformational perturbations that account for streptomycin's action on the ribosome. Mtub_16S_STR rrs antibiotic_resistance ARO:3003480 Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to streptomycin ARO:3003480 Point mutations within the 530 loop of the 16S rRNA of Mycobacterium tuberculosis can result in resistance against streptomycin. These mutations do not directly inhibit the binding of streptomycin, but is hypothesized that they interfere with conformational perturbations that account for streptomycin's action on the ribosome. ISBN:978-92-4-008241-0 PMID:18541729 PMID:30337678 PMID:35072512 PMID:35944069 PMID:7934937 PMID:8192448 PMID:8913445 PMID:9244267 Mtub_16S_STR Point mutations in the 3' domain of 16S rRNA of Mycobacterium tuberculosis can confer resistance to amikacin. Mtub_16S_AMK rrs antibiotic_resistance ARO:3003481 Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to amikacin ARO:3003481 Point mutations in the 3' domain of 16S rRNA of Mycobacterium tuberculosis can confer resistance to amikacin. ISBN:978-92-4-008241-0 PMID:30337678 PMID:35944069 PMID:9593173 Mtub_16S_AMK Point mutation in the 16S rRNA helix 34 region of Chlamydophila psittaci can confer resistance against spectinomycin. Cpsi_16S_SPT antibiotic_resistance ARO:3003485 Chlamydophila psittaci 16S rRNA mutation conferring resistance to spectinomycin ARO:3003485 Point mutation in the 16S rRNA helix 34 region of Chlamydophila psittaci can confer resistance against spectinomycin. PMID:15980362 Cpsi_16S_SPT Point mutations in the helix 34 region of 16S rRNA of Pasteurella multocida can confer resistance to spectinomycin. Pmul_16S_SPT antibiotic_resistance ARO:3003493 Pasteurella multocida 16S rRNA mutation conferring resistance to spectinomycin ARO:3003493 Point mutations in the helix 34 region of 16S rRNA of Pasteurella multocida can confer resistance to spectinomycin. PMID:17371823 Pmul_16S_SPT Point mutations in the helix 34 region of 16S rRNA of Neisseria gonorrhoeae can confer resistance against spectinomycin. Ngon_16S_SPT antibiotic_resistance ARO:3003495 Neisseria gonorrhoeae 16S rRNA mutation conferring resistance to spectinomycin ARO:3003495 Point mutations in the helix 34 region of 16S rRNA of Neisseria gonorrhoeae can confer resistance against spectinomycin. PMID:10770780 Ngon_16S_SPT Point mutations in the 16S rRNA of Neisseria meningitidis can confer resistance to spectinomycin. Nmen_16S_SPT antibiotic_resistance ARO:3003497 Neisseria meningitidis 16S rRNA mutation conferring resistance to spectinomycin ARO:3003497 Point mutations in the 16S rRNA of Neisseria meningitidis can confer resistance to spectinomycin. PMID:10770780 Nmen_16S_SPT Tetracycline binds tightly to the helix 34 domain in 16S rRNA, where it interferes sterically with the binding of aminoacyl-tRNA to the ribosome A site to block protein synthesis. Mutations in the nucleotide sequence in this domain for Cutibacterium acnes can result in resistance against tetracycline. Cacn_16S_TET antibiotic_resistance ARO:3003499 Cutibacterium acnes 16S rRNA mutation conferring resistance to tetracycline ARO:3003499 Tetracycline binds tightly to the helix 34 domain in 16S rRNA, where it interferes sterically with the binding of aminoacyl-tRNA to the ribosome A site to block protein synthesis. Mutations in the nucleotide sequence in this domain for Cutibacterium acnes can result in resistance against tetracycline. PMID:9661007 Cacn_16S_TET Point mutations in the 3' major domain of the 16S rRNA gene of Borreliella burgdorferi can confer resistance to spectinomycin. Bbur_16S_SPT antibiotic_resistance ARO:3003502 Borreliella burgdorferi 16S rRNA mutation conferring resistance to spectinomycin ARO:3003502 Point mutations in the 3' major domain of the 16S rRNA gene of Borreliella burgdorferi can confer resistance to spectinomycin. PMID:16436695 Bbur_16S_SPT Point mutations in the 3' minor domain of the 16S rRNA gene of Borreliella burgdorferi can confer resistance to kanamycin. Bbur_16S_KAN antibiotic_resistance ARO:3003503 Borreliella burgdorferi 16S rRNA mutation conferring resistance to kanamycin ARO:3003503 Point mutations in the 3' minor domain of the 16S rRNA gene of Borreliella burgdorferi can confer resistance to kanamycin. PMID:16436695 Bbur_16S_KAN Point mutations in the 3' minor domain of the 16S rRNA gene of Borreliella burgdorferi can confer resistance to gentamicin. Bbur_16S_GEN antibiotic_resistance ARO:3003504 Borreliella burgdorferi 16S rRNA mutation conferring resistance to gentamicin ARO:3003504 Point mutations in the 3' minor domain of the 16S rRNA gene of Borreliella burgdorferi can confer resistance to gentamicin. PMID:16436695 Bbur_16S_GEN Tetracycline binds tightly to the helix 34 domain in 16S rRNA, where it interferes sterically with the binding of aminoacyl-tRNA to the ribosome A site to block protein synthesis. Mutations in the nucleotide sequence in this domain of Helicobacter pylori can result in resistance against tetracycline. Hpyl_16S_TET antibiotic_resistance ARO:3003510 Helicobacter pylori 16S rRNA mutation conferring resistance to tetracycline ARO:3003510 Tetracycline binds tightly to the helix 34 domain in 16S rRNA, where it interferes sterically with the binding of aminoacyl-tRNA to the ribosome A site to block protein synthesis. Mutations in the nucleotide sequence in this domain of Helicobacter pylori can result in resistance against tetracycline. PMID:11914344 PMID:12183259 PMID:12435699 PMID:20035020 Hpyl_16S_TET SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability. Ecol_soxS_MULT antibiotic_resistance ARO:3003511 Escherichia coli soxS with mutation conferring antibiotic resistance ARO:3003511 SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability. PMID:25921515 Ecol_soxS_MULT Point mutations in the helix 34 region of the rrsD 16S rRNA gene of Salmonella enterica serovar Typhimurium can confer resistance to spectinomycin. Sent_16S_SPT antibiotic_resistance ARO:3003512 Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin ARO:3003512 Point mutations in the helix 34 region of the rrsD 16S rRNA gene of Salmonella enterica serovar Typhimurium can confer resistance to spectinomycin. PMID:12402084 Sent_16S_SPT Point mutations in the 16S rRNA of Mycobacteroides chelonae can cause resistance to amikacin. Mche_16S_AMK antibiotic_resistance ARO:3003514 Mycobacteroides chelonae 16S rRNA mutation conferring resistance to amikacin ARO:3003514 Point mutations in the 16S rRNA of Mycobacteroides chelonae can cause resistance to amikacin. PMID:9607835 Mche_16S_AMK Point mutations in the 16S rRNA of Mycobacteroides chelonae can cause resistance to kanamycin A. Mche_16S_KAN antibiotic_resistance ARO:3003515 Mycobacteroides chelonae 16S rRNA mutation conferring resistance to kanamycin A ARO:3003515 Point mutations in the 16S rRNA of Mycobacteroides chelonae can cause resistance to kanamycin A. PMID:9607835 Mche_16S_KAN Point mutations in the 16S rRNA of Mycobacteroides chelonae can cause resistance to tobramycin. Mche_16S_TOB antibiotic_resistance ARO:3003516 Mycobacteroides chelonae 16S rRNA mutation conferring resistance to tobramycin ARO:3003516 Point mutations in the 16S rRNA of Mycobacteroides chelonae can cause resistance to tobramycin. PMID:9607835 Mche_16S_TOB Point mutations in the 16S rRNA of Mycobacteroides chelonae can confer resistance to gentamicin C. Mche_16S_GENC antibiotic_resistance ARO:3003517 Mycobacteroides chelonae 16S rRNA mutation conferring resistance to gentamicin C ARO:3003517 Point mutations in the 16S rRNA of Mycobacteroides chelonae can confer resistance to gentamicin C. PMID:9607835 Mche_16S_GENC Point mutations in the 16S rRNA of Mycobacteroides chelonae can cause resistance to neomycin. Mche_16S_NEO antibiotic_resistance ARO:3003518 Mycobacteroides chelonae 16S rRNA mutation conferring resistance to neomycin ARO:3003518 Point mutations in the 16S rRNA of Mycobacteroides chelonae can cause resistance to neomycin. PMID:9607835 Mche_16S_NEO Sensitive form of 16s susceptable to antibiotics. antibiotic_resistance ARO:3003520 Antibiotic sensitive Borreliella burgdorferi 16S rRNA ARO:3003520 Sensitive form of 16s susceptable to antibiotics. antibiotic_resistance ARO:3003521 Antibiotic sensitive Chlamydophila psittaci 16S rRNA ARO:3003521 Sensitive form of 16s susceptable to antibiotics. antibiotic_resistance ARO:3003522 Antibiotic sensitive Helicobacter pylori 16S rRNA ARO:3003522 Sensitive form of 16s susceptable to antibiotics. antibiotic_resistance ARO:3003523 Antibiotic sensitive Mycobacteroides chelonae 16S rRNA ARO:3003523 Sensitive form of 16s susceptable to antibiotics. antibiotic_resistance ARO:3003524 Antibiotic sensitive Mycolicibacterium smegmatis 16S rRNA ARO:3003524 Sensitive form of 16s susceptable to antibiotics. antibiotic_resistance ARO:3003525 Antibiotic sensitive Neisseria gonorrhoeae 16S rRNA ARO:3003525 Sensitive form of 16s susceptable to antibiotics. antibiotic_resistance ARO:3003526 Antibiotic sensitive Neisseria meningitidis 16S rRNA ARO:3003526 Sensitive form of 16s susceptable to antibiotics. antibiotic_resistance ARO:3003527 Antibiotic sensitive Pasteurella multocida 16S rRNA ARO:3003527 Sensitive form of 16s susceptable to antibiotics. antibiotic_resistance ARO:3003528 Antibiotic sensitive Cutibacterium acnes 16S rRNA ARO:3003528 Sensitive form of 16s susceptable to antibiotics. antibiotic_resistance ARO:3003529 Antibiotic sensitive Salmonella enterica serovar Typhimurium 16S rRNA ARO:3003529 Sensitive form of 16s susceptable to antibiotics. antibiotic_resistance ARO:3003530 Antibiotic sensitive Mycobacterium tuberculosis 16S rRNA ARO:3003530 Point mutations in the highly conserved helix 44 of the 16S rrsA rRNA gene of Mycolicibacterium smegmatis can confer resistance to hygromycin B. Resistance against hygromycin B is the result of conformational alterations that distorts a strong hydrogen bond leading to a change in the local geometry of the hygromycin B binding site. Msme_16rrsA_HGM antibiotic_resistance ARO:3003539 Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to hygromycin B ARO:3003539 Point mutations in the highly conserved helix 44 of the 16S rrsA rRNA gene of Mycolicibacterium smegmatis can confer resistance to hygromycin B. Resistance against hygromycin B is the result of conformational alterations that distorts a strong hydrogen bond leading to a change in the local geometry of the hygromycin B binding site. PMID:12709313 Msme_16rrsA_HGM Point mutations in the highly conserved helix 44 of the 16S rrsB rRNA gene of Mycolicibacterium smegmatis can confer resistance to hygromycin B. Resistance against hygromycin B is the result of conformational alterations that distorts a strong hydrogen bond leading to a change in the local geometry of the hygromycin B binding site. Msme_16rrsB_HGM antibiotic_resistance ARO:3003540 Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to hygromycin B ARO:3003540 Point mutations in the highly conserved helix 44 of the 16S rrsB rRNA gene of Mycolicibacterium smegmatis can confer resistance to hygromycin B. Resistance against hygromycin B is the result of conformational alterations that distorts a strong hydrogen bond leading to a change in the local geometry of the hygromycin B binding site. PMID:12709313 Msme_16rrsB_HGM Point mutations in the helix 44 region of the 16S rRNA rrsB gene of Mycolicibacterium smegmatis can confer resistance to streptomycin. Msme_16rrsB_STR antibiotic_resistance ARO:3003541 Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to streptomycin ARO:3003541 Point mutations in the helix 44 region of the 16S rRNA rrsB gene of Mycolicibacterium smegmatis can confer resistance to streptomycin. PMID:11557484 Msme_16rrsB_STR Point mutations in the helix 44 region of the 16S rRNA rrsB gene of Mycolicibacterium smegmatis can confer resistance to kanamycin A. Msme_16rrsB_KAN antibiotic_resistance ARO:3003542 Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to kanamycin A ARO:3003542 Point mutations in the helix 44 region of the 16S rRNA rrsB gene of Mycolicibacterium smegmatis can confer resistance to kanamycin A. PMID:9244267 Msme_16rrsB_KAN Point mutations in the helix 44 region of the 16S rRNA rrsA gene of Mycolicibacterium smegmatis can confer resistance to kanamycin A. Msme_16rrsA_KAN antibiotic_resistance ARO:3003543 Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to kanamycin A ARO:3003543 Point mutations in the helix 44 region of the 16S rRNA rrsA gene of Mycolicibacterium smegmatis can confer resistance to kanamycin A. PMID:9244267 Msme_16rrsA_KAN Point mutations in the helix 44 region of the 16S rRNA rrsA gene of Mycolicibacterium smegmatis can confer resistance to neomycin. Msme_16rrsA_NEO antibiotic_resistance ARO:3003544 Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to neomycin ARO:3003544 Point mutations in the helix 44 region of the 16S rRNA rrsA gene of Mycolicibacterium smegmatis can confer resistance to neomycin. PMID:9244267 Msme_16rrsA_NEO Point mutations in the helix 44 region of the 16S rRNA rrsB gene of Mycolicibacterium smegmatis can confer resistance to neomycin. Msme_16rrsB_NEO antibiotic_resistance ARO:3003545 Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to neomycin ARO:3003545 Point mutations in the helix 44 region of the 16S rRNA rrsB gene of Mycolicibacterium smegmatis can confer resistance to neomycin. PMID:9244267 Msme_16rrsB_NEO Point mutations in the helix 44 region of the 16S rRNA rrsA gene of Mycolicibacterium smegmatis can confer resistance to viomycin. Msme_16rrsA_VIO antibiotic_resistance ARO:3003546 Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to viomycin ARO:3003546 Point mutations in the helix 44 region of the 16S rRNA rrsA gene of Mycolicibacterium smegmatis can confer resistance to viomycin. PMID:9244267 Msme_16rrsA_VIO Point mutations in the helix 44 region of the 16S rRNA rrsB gene of Mycolicibacterium smegmatis can confer resistance to viomycin. Msme_16rrsB_VIO antibiotic_resistance ARO:3003547 Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to viomycin ARO:3003547 Point mutations in the helix 44 region of the 16S rRNA rrsB gene of Mycolicibacterium smegmatis can confer resistance to viomycin. PMID:9244267 Msme_16rrsB_VIO Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride. mdtN sdsR yjcR antibiotic_resistance ARO:3003548 mdtN ARO:3003548 Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride. PMID:11257026 PMID:19429622 PMID:8021163 mdtN Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride. mdtO sdsQ yjcQ antibiotic_resistance ARO:3003549 mdtO ARO:3003549 Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride. PMID:11257026 PMID:19429622 mdtO Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride. mdtP sdsP yjcP antibiotic_resistance ARO:3003550 mdtP ARO:3003550 Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride. PMID:11257026 PMID:19429622 mdtP A multidrug efflux pump from Enterococcus faecalis. There exist efflux activity of several antimicrobial agents such as DAPI, Hoechst 33342 and acriflavine. Efflux of DAPI via EmeA was strongly inhibited by reserpine. emeA antibiotic_resistance ARO:3003551 emeA ARO:3003551 A multidrug efflux pump from Enterococcus faecalis. There exist efflux activity of several antimicrobial agents such as DAPI, Hoechst 33342 and acriflavine. Efflux of DAPI via EmeA was strongly inhibited by reserpine. PMID:12576692 emeA FusB encodes a 2-domain zinc-binding protein that binds the ribosomal translocase EF-G, causing it to dissociate from the ribosome. This action increases the ribosomal turnover rate and confers resistance to fusidic acid. This protein is considered a FusB-type protein. fusB antibiotic_resistance ARO:3003552 fusB ARO:3003552 FusB encodes a 2-domain zinc-binding protein that binds the ribosomal translocase EF-G, causing it to dissociate from the ribosome. This action increases the ribosomal turnover rate and confers resistance to fusidic acid. This protein is considered a FusB-type protein. PMID:16390458 PMID:22308410 fusB CEPS is a typical class C cephalosporinase found in Aeromonas sobria, first isolated from strain 163a. CepS antibiotic_resistance ARO:3003553 CepS ARO:3003553 CEPS is a typical class C cephalosporinase found in Aeromonas sobria, first isolated from strain 163a. PMID:11062187 CepS Major facilitator superfamily transporter. Resistance to tetracenomycin C by an active tetracenomycin C efflux system which is probably energized by transmembrane electrochemical gradients. tcmA antibiotic_resistance ARO:3003554 tcmA ARO:3003554 Major facilitator superfamily transporter. Resistance to tetracenomycin C by an active tetracenomycin C efflux system which is probably energized by transmembrane electrochemical gradients. PMID:1592819 tcmA This family of sublcass B1 beta-lactamases were discovered in species of the Shewanella genus. antibiotic_resistance ARO:3003555 SHW beta-lactamase ARO:3003555 This family of sublcass B1 beta-lactamases were discovered in species of the Shewanella genus. PMID:15772146 This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properties. SLB-1 antibiotic_resistance ARO:3003556 SLB-1 ARO:3003556 This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properties. PMID:15772146 SLB-1 This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properties. SFB-1 antibiotic_resistance ARO:3003557 SFB-1 ARO:3003557 This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properties. PMID:15772146 SFB-1 Class A beta-lactamase found in Yersinia enterocolitica biovar 1A. Yent_y56 antibiotic_resistance ARO:3003558 y56 beta-lactamase ARO:3003558 Class A beta-lactamase found in Yersinia enterocolitica biovar 1A. PMID:16553870 Yent_y56 A beta-lactamase found in Bacteroides fragilis producing either low or high levels of the endogenous cephalosporinase activity. cepA antibiotic_resistance ARO:3003559 cepA ARO:3003559 A beta-lactamase found in Bacteroides fragilis producing either low or high levels of the endogenous cephalosporinase activity. PMID:7517394 cepA SED-1 is a chromosomal-encoded class A beta-lactamase identified in Citrobacter sedlakii. SED-1 antibiotic_resistance ARO:3003561 SED-1 ARO:3003561 SED-1 is a chromosomal-encoded class A beta-lactamase identified in Citrobacter sedlakii. PMID:11451687 SED-1 Class A beta-lactamase found in Mycolicibacterium fortuitum. blaF antibiotic_resistance ARO:3003562 blaF ARO:3003562 Class A beta-lactamase found in Mycolicibacterium fortuitum. PMID:8065266 blaF RCP is a class A beta-lactamase found in Rhodopseudomonas capsulata. RCP-1 antibiotic_resistance ARO:3003563 RCP-1 ARO:3003563 RCP is a class A beta-lactamase found in Rhodopseudomonas capsulata. PMID:2788410 RCP-1 Class A beta-lactamase found in Streptomyces albus G. ALBUS EXO-1 antibiotic_resistance ARO:3003564 EXO-1 ARO:3003564 Class A beta-lactamase found in Streptomyces albus G. PMID:1540134 EXO-1 Class A beta-lactamase found in Actinomadura R39. R39 antibiotic_resistance ARO:3003565 R39 ARO:3003565 Class A beta-lactamase found in Actinomadura R39. PMID:2515104 R39 Magainins A are antimicrobial peptides produced by amphibians as part of their innate immune system. PubChem:16132424 antibiotic_resistance ARO:3003567 magainin A ARO:3003567 Magainins A are antimicrobial peptides produced by amphibians as part of their innate immune system. PMID:2285300 Magainin B is is a synthetic analog of magainin 1, an antimicrobial peptide. PubChem:16131332 antibiotic_resistance ARO:3003568 Magainin B ARO:3003568 Magainin B is is a synthetic analog of magainin 1, an antimicrobial peptide. PMID:2285300 Magainin G is is a synthetic analog of magainin 1, an antimicrobial peptide. It differs from magainin B by the addition of an beta-alanine at the N terminal. PubChem:16132425 antibiotic_resistance ARO:3003569 Magainin G ARO:3003569 Magainin G is is a synthetic analog of magainin 1, an antimicrobial peptide. It differs from magainin B by the addition of an beta-alanine at the N terminal. PMID:2285300 Magainin H is is a synthetic analog of magainin 1, an antimicrobial peptide. It differs from magainin B with the substitution of D-alanine instead of L-alanine. PubChem:16132431 antibiotic_resistance ARO:3003570 Magainin H ARO:3003570 Magainin H is is a synthetic analog of magainin 1, an antimicrobial peptide. It differs from magainin B with the substitution of D-alanine instead of L-alanine. PMID:2285300 Magainin1 is an antimicrobial peptides produced by amphibians as part of their innate immune system. It is derived from the Xenopus laevis. ChEBI:201898 ChEMBL:CHEMBL437357 PubChem:16132169 antibiotic_resistance ARO:3003571 magainin 1 ARO:3003571 Magainin1 is an antimicrobial peptides produced by amphibians as part of their innate immune system. It is derived from the Xenopus laevis. PMID:3277183 Magainin 2 is an antimicrobial peptides produced from Xenopus laevis skin. It induce osmotic lysis of bacteria. ChEBI:201476 ChEMBL:CHEMBL414933 PubChem:16130189 antibiotic_resistance ARO:3003572 magainin 2 ARO:3003572 Magainin 2 is an antimicrobial peptides produced from Xenopus laevis skin. It induce osmotic lysis of bacteria. PMID:3277183 The LpxA gene is widely known to be involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane. LpxA antibiotic_resistance ARO:3003573 LpxA ARO:3003573 The LpxA gene is widely known to be involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane. PMID:20855724 PMID:24189257 LpxA The LpxC gene is widely known to be involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane. LpxC antibiotic_resistance ARO:3003574 LpxC ARO:3003574 The LpxC gene is widely known to be involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane. PMID:20855724 PMID:24189257 LpxC The LpxD gene is widely known to be involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane. LpxD antibiotic_resistance ARO:3003575 LpxD ARO:3003575 The LpxD gene is widely known to be involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane. PMID:20855724 PMID:24189257 LpxD PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine, resulting in a less negative cell membrane and decreased binding of polymyxin B. PmrC eptA antibiotic_resistance ARO:3003576 eptA ARO:3003576 PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine, resulting in a less negative cell membrane and decreased binding of polymyxin B. PMID:15205413 eptA PmrE is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A, which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. ECK2023 JW2010 pagA pmrE udg ugd yefA antibiotic_resistance ARO:3003577 ugd ARO:3003577 PmrE is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A, which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. PMID:15205413 PMID:9570402 ugd PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A, which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. PmrF arnC antibiotic_resistance ARO:3003578 PmrF ARO:3003578 PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A, which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58. PMID:9570402 PmrF BasRS is a two-component regulatory system. BasR is phosphorylated by BasS at high[Fe3+] levels. The BasRS system regulates the expression of pmrE, pmrF and pmrC, leading to antibiotic resistance. pmrAB antibiotic_resistance ARO:3003579 basRS ARO:3003579 BasRS is a two-component regulatory system. BasR is phosphorylated by BasS at high[Fe3+] levels. The BasRS system regulates the expression of pmrE, pmrF and pmrC, leading to antibiotic resistance. PMID:24412662 Genes involved in alteration of the cell wall overall charge, leading to antimicrobial resistance due to reduced binding. antibiotic_resistance ARO:3003580 gene altering cell wall charge ARO:3003580 These genes are involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane. Mutation by absence or insertion of ISAba11 sequence is a known cause of resistance in Acinetobacter baumannii▿. antibiotic_resistance ARO:3003581 Acinetobacter mutant Lpx gene conferring resistance to colistin ARO:3003581 These genes are involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane. Mutation by absence or insertion of ISAba11 sequence is a known cause of resistance in Acinetobacter baumannii▿. PMID:21402838 PMID:24189257 Response regulator for Lipid A modification genes; two-component system involved in polymyxin resistance that senses high extracellular Fe(2+). basR antibiotic_resistance ARO:3003582 basR ARO:3003582 Response regulator for Lipid A modification genes; two-component system involved in polymyxin resistance that senses high extracellular Fe(2+). PMID:24412662 PMID:25006521 basR Histidine protein kinase sensor Lipid A modification gene; part of a two-component system involved in polymyxin resistance that senses high extracellular Fe(2+). basS pmrB antibiotic_resistance ARO:3003583 basS ARO:3003583 Histidine protein kinase sensor Lipid A modification gene; part of a two-component system involved in polymyxin resistance that senses high extracellular Fe(2+). PMID:14507375 PMID:25006521 basS A mutant phoP activates pmrHFIJKLM expression responsible for L-aminoarabinose synthesis and polymyxin resistance, by way of alteration of negative charge. Kleb_PhoP_CST antibiotic_resistance ARO:3003585 Klebsiella mutant PhoP conferring antibiotic resistance to colistin ARO:3003585 A mutant phoP activates pmrHFIJKLM expression responsible for L-aminoarabinose synthesis and polymyxin resistance, by way of alteration of negative charge. PMID:25733503 Kleb_PhoP_CST The loss or reduction of the net negative charge within the cell wall of gram negative bacteria is a mechanism of resistance for cationic antimicrobials that depend on the negative charge for binding to the surface. antibiotic_resistance ARO:3003588 charge alteration conferring antibiotic resistance ARO:3003588 NmcA is a class A serine beta-lactamase isolated from Enterobacter cloacae. NmcA blaNMC-A antibiotic_resistance ARO:3003589 NmcA ARO:3003589 NmcA is a class A serine beta-lactamase isolated from Enterobacter cloacae. PMID:8052644 NmcA SHV-190 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. SHV-190 antibiotic_resistance ARO:3003590 SHV-190 ARO:3003590 SHV-190 SHV-191 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. SHV-191 antibiotic_resistance ARO:3003591 SHV-191 ARO:3003591 SHV-191 TEM-223 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3003592 TEM-223 ARO:3003592 OXA-437 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-437 antibiotic_resistance ARO:3003593 OXA-437 ARO:3003593 OXA-437 OXA-438 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-438 antibiotic_resistance ARO:3003594 OXA-438 ARO:3003594 OXA-438 OXA-439 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-439 antibiotic_resistance ARO:3003595 OXA-439 ARO:3003595 OXA-439 OXA-440 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-440 antibiotic_resistance ARO:3003596 OXA-440 ARO:3003596 OXA-440 OXA-441 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-441 antibiotic_resistance ARO:3003597 OXA-441 ARO:3003597 OXA-441 OXA-442 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-442 antibiotic_resistance ARO:3003598 OXA-442 ARO:3003598 OXA-442 OXA-443 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-443 antibiotic_resistance ARO:3003599 OXA-443 ARO:3003599 OXA-443 OXA-444 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-444 antibiotic_resistance ARO:3003600 OXA-444 ARO:3003600 OXA-444 OXA-445 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3003601 OXA-445 ARO:3003601 OXA-446 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-446 antibiotic_resistance ARO:3003602 OXA-446 ARO:3003602 OXA-446 OXA-447 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-447 antibiotic_resistance ARO:3003603 OXA-447 ARO:3003603 OXA-447 OXA-448 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-448 antibiotic_resistance ARO:3003604 OXA-448 ARO:3003604 OXA-448 OXA-449 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-449 antibiotic_resistance ARO:3003605 OXA-449 ARO:3003605 OXA-449 OXA-450 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-450 antibiotic_resistance ARO:3003606 OXA-450 ARO:3003606 OXA-450 OXA-451 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-451 antibiotic_resistance ARO:3003607 OXA-451 ARO:3003607 OXA-451 OXA-452 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-452 antibiotic_resistance ARO:3003608 OXA-452 ARO:3003608 OXA-452 OXA-453 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-453 antibiotic_resistance ARO:3003609 OXA-453 ARO:3003609 OXA-453 OXA-454 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-454 antibiotic_resistance ARO:3003610 OXA-454 ARO:3003610 OXA-454 OXA-455 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-455 antibiotic_resistance ARO:3003611 OXA-455 ARO:3003611 OXA-455 OXA-456 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3003612 OXA-456 ARO:3003612 OXA-457 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-457 antibiotic_resistance ARO:3003613 OXA-457 ARO:3003613 OXA-457 OXA-458 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-458 antibiotic_resistance ARO:3003614 OXA-458 ARO:3003614 OXA-458 OXA-459 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-459 antibiotic_resistance ARO:3003615 OXA-459 ARO:3003615 OXA-459 OXA-460 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-460 antibiotic_resistance ARO:3003616 OXA-460 ARO:3003616 OXA-460 OXA-461 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-461 antibiotic_resistance ARO:3003617 OXA-461 ARO:3003617 OXA-461 OXA-462 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3003618 OXA-462 ARO:3003618 OXA-463 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3003619 OXA-463 ARO:3003619 OXA-464 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-464 antibiotic_resistance ARO:3003620 OXA-464 ARO:3003620 OXA-464 OXA-465 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-465 antibiotic_resistance ARO:3003621 OXA-465 ARO:3003621 OXA-465 OXA-466 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-466 antibiotic_resistance ARO:3003622 OXA-466 ARO:3003622 OXA-466 OXA-467 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3003623 OXA-467 ARO:3003623 OXA-468 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3003624 OXA-468 ARO:3003624 OXA-469 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3003625 OXA-469 ARO:3003625 OXA-470 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-470 antibiotic_resistance ARO:3003626 OXA-470 ARO:3003626 OXA-470 OXA-471 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-471 antibiotic_resistance ARO:3003627 OXA-471 ARO:3003627 OXA-471 OXA-472 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-472 antibiotic_resistance ARO:3003628 OXA-472 ARO:3003628 OXA-472 OXA-473 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-473 antibiotic_resistance ARO:3003629 OXA-473 ARO:3003629 OXA-473 OXA-474 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-474 antibiotic_resistance ARO:3003631 OXA-474 ARO:3003631 OXA-474 OXA-475 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-475 antibiotic_resistance ARO:3003632 OXA-475 ARO:3003632 OXA-475 OXA-476 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-476 antibiotic_resistance ARO:3003633 OXA-476 ARO:3003633 OXA-476 OXA-477 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-477 antibiotic_resistance ARO:3003634 OXA-477 ARO:3003634 OXA-477 OXA-478 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-478 antibiotic_resistance ARO:3003635 OXA-478 ARO:3003635 OXA-478 OXA-479 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-479 antibiotic_resistance ARO:3003636 OXA-479 ARO:3003636 OXA-479 OXA-480 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-480 antibiotic_resistance ARO:3003637 OXA-480 ARO:3003637 OXA-480 OXA-481 is a carbapenem-hydrolyzing class D beta-lactamase. OXA-481 antibiotic_resistance ARO:3003638 OXA-481 ARO:3003638 OXA-481 OXA-482 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-482 antibiotic_resistance ARO:3003639 OXA-482 ARO:3003639 OXA-482 OXA-483 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-483 antibiotic_resistance ARO:3003640 OXA-483 ARO:3003640 OXA-483 OXA-484 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-484 antibiotic_resistance ARO:3003641 OXA-484 ARO:3003641 OXA-484 OXA-485 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-485 antibiotic_resistance ARO:3003642 OXA-485 ARO:3003642 OXA-485 OXA-486 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-486 antibiotic_resistance ARO:3003643 OXA-486 ARO:3003643 OXA-486 OXA-487 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3003644 OXA-487 ARO:3003644 OXA-488 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. OXA-488 antibiotic_resistance ARO:3003645 OXA-488 ARO:3003645 OXA-488 CTX-M-162 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-162 antibiotic_resistance ARO:3003646 CTX-M-162 ARO:3003646 CTX-M-162 CTX-M-163 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-163 antibiotic_resistance ARO:3003647 CTX-M-163 ARO:3003647 CTX-M-163 CTX-M-164 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-164 antibiotic_resistance ARO:3003648 CTX-M-164 ARO:3003648 CTX-M-164 CTX-M-165 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-165 antibiotic_resistance ARO:3003649 CTX-M-165 ARO:3003649 CTX-M-165 CTX-M-166 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CTX-M-166 antibiotic_resistance ARO:3003650 CTX-M-166 ARO:3003650 CTX-M-166 CMY-132 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-132 antibiotic_resistance ARO:3003652 CMY-132 ARO:3003652 CMY-132 CMY-133 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. CMY-133 antibiotic_resistance ARO:3003653 CMY-133 ARO:3003653 CMY-133 CMY-134 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. CMY-134 antibiotic_resistance ARO:3003654 CMY-134 ARO:3003654 CMY-134 A class C beta-lactamase from Citrobacter freundii. ACT-38 antibiotic_resistance ARO:3003655 ACT-38 ARO:3003655 ACT-38 IMP-49 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. IMP-49 antibiotic_resistance ARO:3003657 IMP-49 ARO:3003657 IMP-49 IMP-50 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. antibiotic_resistance ARO:3003658 IMP-50 ARO:3003658 IMP-51 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. IMP-51 antibiotic_resistance ARO:3003659 IMP-51 ARO:3003659 IMP-51 VIM-44 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. VIM-44 antibiotic_resistance ARO:3003660 VIM-44 ARO:3003660 VIM-44 VIM-45 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. VIM-45 antibiotic_resistance ARO:3003661 VIM-45 ARO:3003661 VIM-45 VIM-46 is a beta-lactamase. Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. VIM-46 antibiotic_resistance ARO:3003662 VIM-46 ARO:3003662 VIM-46 New Delhi metallo-beta-lactamase-15 variant of NDM-1. NDM-15 antibiotic_resistance ARO:3003663 NDM-15 ARO:3003663 NDM-15 New Delhi class B metallo-beta-lactamase-16a variant of NDM-1. NDM-16 NDM-16a antibiotic_resistance ARO:3003664 NDM-16a ARO:3003664 NDM-16a NmcR is a homolog of the LysR regulator found in Enterobacter cloacae that contribute to the regulation of NmcA beta-lactamase. NmcR antibiotic_resistance ARO:3003665 NmcR ARO:3003665 NmcR is a homolog of the LysR regulator found in Enterobacter cloacae that contribute to the regulation of NmcA beta-lactamase. PMID:8052644 NmcR Point mutations in the 16S rRNA of bacteria can confer resistance to aminoglycosides. antibiotic_resistance ARO:3003666 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics ARO:3003666 Point mutations in the 16S rRNA of bacteria can confer resistance to peptide antibiotics. antibiotic_resistance ARO:3003667 16s rRNA with mutation conferring resistance to peptide antibiotics ARO:3003667 Point mutations in the 16S rRNA of bacteria can confer resistance to polyamine antibiotics. antibiotic_resistance ARO:3003668 16s rRNA with mutation conferring resistance to polyamine antibiotics ARO:3003668 Point mutations in the bacterial 16S rRNA region shown clinically to confer resistance to tetracycline and tetracycline derivatives (polyketide antibiotics). antibiotic_resistance ARO:3003669 16S rRNA with mutation conferring resistance to tetracycline derivatives ARO:3003669 PEDO-1 is a subclass B3 metallo-beta lactamase isolated from Pedobacter roseus exhibiting resistance to carbapenems. PEDO-1 antibiotic_resistance ARO:3003670 PEDO-1 ARO:3003670 PEDO-1 is a subclass B3 metallo-beta lactamase isolated from Pedobacter roseus exhibiting resistance to carbapenems. PMID:26482314 PEDO-1 Plazomicin is a neoglycoside, or next-generation, aminoglycoside, that has been identified as a potentially useful agent to combat drug-resistant bacteria, such as Acinetobacter baumannii and Pseudomonas aeruginosa. ChEMBL:CHEMBL1650559 PubChem:42613186 ACHN-490 antibiotic_resistance ARO:3003675 plazomicin ARO:3003675 Plazomicin is a neoglycoside, or next-generation, aminoglycoside, that has been identified as a potentially useful agent to combat drug-resistant bacteria, such as Acinetobacter baumannii and Pseudomonas aeruginosa. PMID:21131322 AAC(6')-Ib' is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in P. aeruginosa and P. fluorescens. AAC(6')-Ib' antibiotic_resistance ARO:3003676 AAC(6')-Ib' ARO:3003676 AAC(6')-Ib' is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in P. aeruginosa and P. fluorescens. PMID:10720551 PMID:8138142 AAC(6')-Ib' AAC(6')-Iaj is a functional acetyltransferase that modifies the amino groups at the 6' positions of aminoglycosides and contributes to aminoglycoside resistance of P. aeruginosa. AAC(6')-Iaj antibiotic_resistance ARO:3003677 AAC(6')-Iaj ARO:3003677 AAC(6')-Iaj is a functional acetyltransferase that modifies the amino groups at the 6' positions of aminoglycosides and contributes to aminoglycoside resistance of P. aeruginosa. PMID:23070167 AAC(6')-Iaj TriABC-OpmH is a triclosan-specific efflux pump expressed in the Gram-negative Pseudomonas aeruginosa. TriABC is the only P. aeruginosa resistance nodulation cell division (RND) pump which contains two membrane fusion proteins, TriA and TriB, and both are required for efflux pump function. TriABC associated with OpmH assemble a functional triclosan efflux pump. TriABC-OpmH antibiotic_resistance ARO:3003678 TriABC-OpmH ARO:3003678 TriABC-OpmH is a triclosan-specific efflux pump expressed in the Gram-negative Pseudomonas aeruginosa. TriABC is the only P. aeruginosa resistance nodulation cell division (RND) pump which contains two membrane fusion proteins, TriA and TriB, and both are required for efflux pump function. TriABC associated with OpmH assemble a functional triclosan efflux pump. PMID:17720796 TriABC-OpmH TriA is a membrane protein that is fused to TriB and both are required for the triclosan efflux pump function of TriABC-OpmH in P. aeruginosa. TriA antibiotic_resistance ARO:3003679 TriA ARO:3003679 TriA is a membrane protein that is fused to TriB and both are required for the triclosan efflux pump function of TriABC-OpmH in P. aeruginosa. PMID:17720796 TriA TriB is a membrane protein that is fused to TriA and both are required for the triclosan efflux pump function of TriABC-OpmH in P. aeruginosa. TriB antibiotic_resistance ARO:3003680 TriB ARO:3003680 TriB is a membrane protein that is fused to TriA and both are required for the triclosan efflux pump function of TriABC-OpmH in P. aeruginosa. PMID:17720796 TriB TriC is a resistance nodulation cell division (RND) transporter that is a part of TriABC-OpmH, a triclosan-specific efflux protein. TriC antibiotic_resistance ARO:3003681 TriC ARO:3003681 TriC is a resistance nodulation cell division (RND) transporter that is a part of TriABC-OpmH, a triclosan-specific efflux protein. PMID:17720796 TriC OpmH is an outer membrane efflux protein required for triclosan-specific efflux pump function. OpmH antibiotic_resistance ARO:3003682 OpmH ARO:3003682 OpmH is an outer membrane efflux protein required for triclosan-specific efflux pump function. PMID:15855547 PMID:17720796 OpmH Point mutation of Pseudomonas aeruginosa gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance. Paer_gyrA_FLO antibiotic_resistance ARO:3003684 Pseudomonas aeruginosa gyrA conferring resistance to fluoroquinolones ARO:3003684 Point mutation of Pseudomonas aeruginosa gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance. PMID:22821356 PMID:8540700 Paer_gyrA_FLO Point mutation in Pseudomonas aeruginosa parE resulting in sensitivity to fluoroquinolones (ciprofloxacin). In combination with a gyrase mutation (gyrA or gyrB), it confers a high level of resistance to ciprofloxacin. Paer_parE_FLO antibiotic_resistance ARO:3003685 Pseudomonas aeruginosa parE conferring resistance to fluoroquinolones ARO:3003685 Point mutation in Pseudomonas aeruginosa parE resulting in sensitivity to fluoroquinolones (ciprofloxacin). In combination with a gyrase mutation (gyrA or gyrB), it confers a high level of resistance to ciprofloxacin. PMID:23274661 Paer_parE_FLO oprD is an outer membrane porin which facilitates the uptake of basic amino acids and imipenem in Pseudomonas aeruginosa. Paer_oprD_IPM antibiotic_resistance ARO:3003686 Pseudomonas aeruginosa oprD with mutation conferring resistance to imipenem ARO:3003686 oprD is an outer membrane porin which facilitates the uptake of basic amino acids and imipenem in Pseudomonas aeruginosa. PMID:12534469 PMID:23045355 PMID:25297323 Paer_oprD_IPM PvrR is a response regulator that controls the conversion between antibiotic-resistant and antibiotic-susceptible forms of Pseudomonas aeruginosa biofilms through porin deletion/gene absence. PvrR antibiotic_resistance ARO:3003688 PvrR ARO:3003688 PvrR is a response regulator that controls the conversion between antibiotic-resistant and antibiotic-susceptible forms of Pseudomonas aeruginosa biofilms through porin deletion/gene absence. PMID:11961556 PvrR MCR-1 is a plasmid-borne phosphoethanolamine transferase that interferes with binding of colistin to the cell membrane via addition of phosphoethanolamine to lipid A, resulting reduction in negative charge of the cell membrane. MCR-1 MCR-1.1 antibiotic_resistance ARO:3003689 MCR-1.1 ARO:3003689 MCR-1 is a plasmid-borne phosphoethanolamine transferase that interferes with binding of colistin to the cell membrane via addition of phosphoethanolamine to lipid A, resulting reduction in negative charge of the cell membrane. PMID:26603172 MCR-1.1 Sitafloxacin is a fluoroquinolone active against multi-resistant Gram-positive and negative pathogens. Sitafloxacin shows inhibitory activity against DNA gyrase and topoisomerase IV, which blocks bacterial DNA replication, thereby causing double-stranded breaks in the bacterial chromosome. CAS:127254-12-0 ChEBI:4304 ChEMBL:CHEMBL3989504 PubChem:461399 Gracevit antibiotic_resistance ARO:3003690 sitafloxacin ARO:3003690 Sitafloxacin is a fluoroquinolone active against multi-resistant Gram-positive and negative pathogens. Sitafloxacin shows inhibitory activity against DNA gyrase and topoisomerase IV, which blocks bacterial DNA replication, thereby causing double-stranded breaks in the bacterial chromosome. PMID:21504249 MexJK-OpmH is a triclosan efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexJ is the membrane fusion protein, MexK is the inner membrane resistance-nodulation-cell division (RND) transporter, and OpmH is the outer membrane efflux protein. MexJK is constitutively expressed in mexL mutants. MexJK-OpmH antibiotic_resistance ARO:3003691 MexJK-OpmH ARO:3003691 MexJK-OpmH is a triclosan efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexJ is the membrane fusion protein, MexK is the inner membrane resistance-nodulation-cell division (RND) transporter, and OpmH is the outer membrane efflux protein. MexJK is constitutively expressed in mexL mutants. PMID:12193619 PMID:15855505 PMID:15855547 MexJK-OpmH MexJ is the membrane fusion protein of the MexJK multidrug efflux protein. MexJ antibiotic_resistance ARO:3003692 MexJ ARO:3003692 MexJ is the membrane fusion protein of the MexJK multidrug efflux protein. PMID:12193619 MexJ MexK is the inner membrane resistance-nodulation-cell division (RND) transporter in the MexJK multidrug efflux protein. MexK antibiotic_resistance ARO:3003693 MexK ARO:3003693 MexK is the inner membrane resistance-nodulation-cell division (RND) transporter in the MexJK multidrug efflux protein. PMID:12193619 MexK MexJK-OprM is a multidrug efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexJ is the membrane fusion protein, MexK is the inner membrane resistance-nodulation-cell division (RND) transporter, and OprM is the outer membrane factor protein. MexJK-OprM antibiotic_resistance ARO:3003694 MexJK-OprM ARO:3003694 MexJK-OprM is a multidrug efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexJ is the membrane fusion protein, MexK is the inner membrane resistance-nodulation-cell division (RND) transporter, and OprM is the outer membrane factor protein. PMID:15855547 MexJK-OprM MexPQ-OpmE multidrug efflux pump expressed in Pseudomonas aeruginosa. MexP is the membrane fusion protein; MexQ is the inner membrane transporter; and OpmE is the outer membrane channel. MexPQ-OpmE antibiotic_resistance ARO:3003697 MexPQ-OpmE ARO:3003697 MexPQ-OpmE multidrug efflux pump expressed in Pseudomonas aeruginosa. MexP is the membrane fusion protein; MexQ is the inner membrane transporter; and OpmE is the outer membrane channel. PMID:16301811 MexPQ-OpmE MexP is the membrane fusion protein of the MexPQ-OpmE multidrug efflux complex. mexP antibiotic_resistance ARO:3003698 mexP ARO:3003698 MexP is the membrane fusion protein of the MexPQ-OpmE multidrug efflux complex. PMID:16301811 mexP MexQ is the inner membrane transporter of the multidrug efflux pump MexPQ-OpmE. mexQ antibiotic_resistance ARO:3003699 mexQ ARO:3003699 MexQ is the inner membrane transporter of the multidrug efflux pump MexPQ-OpmE. PMID:16301811 mexQ opmE is an outer membrane factor protein that is part of the multidrug efflux pump MexPQ-OpmE. opmE antibiotic_resistance ARO:3003700 opmE ARO:3003700 opmE is an outer membrane factor protein that is part of the multidrug efflux pump MexPQ-OpmE. PMID:16301811 opmE Rokitamycin is a macrolide antibiotic. Synthesized from strains of Streptomyces kitasatoensis. CAS:74014-51-0 ChEBI:32103 ChEMBL:CHEMBL1908350 PubChem:5282211 antibiotic_resistance ARO:3003701 rokitamycin ARO:3003701 Rokitamycin is a macrolide antibiotic. Synthesized from strains of Streptomyces kitasatoensis. PMID:1779258 Point mutation in Pseudomonas aeruginosa parC resulting in fluoroquinolone resistance also requiring a gyrA mutation. Paer_ParC_FLO antibiotic_resistance ARO:3003702 Pseudomonas aeruginosa gyrA and parC conferring resistance to fluoroquinolones ARO:3003702 Point mutation in Pseudomonas aeruginosa parC resulting in fluoroquinolone resistance also requiring a gyrA mutation. PMID:11451683 PMID:22821356 Paer_ParC_FLO MexMN-OprM is a multidrug efflux pump expressed in Pseudomonas aeruginosa. MexM is the membrane fusion protein; MexN is the inner membrane transporter; and OprM is the outer membrane channel. MexMN-OprM antibiotic_resistance ARO:3003703 MexMN-OprM ARO:3003703 MexMN-OprM is a multidrug efflux pump expressed in Pseudomonas aeruginosa. MexM is the membrane fusion protein; MexN is the inner membrane transporter; and OprM is the outer membrane channel. PMID:19713238 MexMN-OprM mexM is the membrane fusion protein of the MexMN-OprM multidrug efflux complex. mexM antibiotic_resistance ARO:3003704 mexM ARO:3003704 mexM is the membrane fusion protein of the MexMN-OprM multidrug efflux complex. PMID:19713238 mexM MexN is the inner membrane transporter of the MexMN-OprM multidrug efflux complex. mexN antibiotic_resistance ARO:3003705 mexN ARO:3003705 MexN is the inner membrane transporter of the MexMN-OprM multidrug efflux complex. PMID:19713238 mexN Faropenem is an orally active beta-lactam antibiotic belonging to the penem group. ChEBI:51788 ChEMBL:CHEMBL556262 PubChem:65894 antibiotic_resistance ARO:3003707 faropenem ARO:3003707 Faropenem is an orally active beta-lactam antibiotic belonging to the penem group. PMID:12615878 Panipenem is a carbapenem antibacterial agent with a broad spectrum of in vitro activity covering a wide range of Gram-negative and Gram-positive aerobic and anaerobic bacterial. It is used in combination with betamipron to inhibit panipenem uptake into the renal tubule and prevent nephrotoxicity. CAS:87726-17-8 ChEBI:7911 ChEMBL:CHEMBL339323 PubChem:72015 antibiotic_resistance ARO:3003708 panipenem ARO:3003708 Panipenem is a carbapenem antibacterial agent with a broad spectrum of in vitro activity covering a wide range of Gram-negative and Gram-positive aerobic and anaerobic bacterial. It is used in combination with betamipron to inhibit panipenem uptake into the renal tubule and prevent nephrotoxicity. PMID:12678575 MexZ is a transcriptional regulator that downregulates the mexXY multidrug transporter operon, which confers to aminoglycoside resistance on Pseudomonas aeruginosa. MexZ antibiotic_resistance ARO:3003709 MexZ ARO:3003709 MexZ is a transcriptional regulator that downregulates the mexXY multidrug transporter operon, which confers to aminoglycoside resistance on Pseudomonas aeruginosa. PMID:15336398 MexZ MexL is a specific repressor of mexJK transcription and autoregulates its own expression. MexL antibiotic_resistance ARO:3003710 MexL ARO:3003710 MexL is a specific repressor of mexJK transcription and autoregulates its own expression. PMID:15855505 MexL VEB-16 (VEB-1b) is a beta-lactamase that is found in Pseudomonas aeruginosa. VEB-16 VEB-1b antibiotic_resistance ARO:3003712 VEB-16 ARO:3003712 VEB-16 (VEB-1b) is a beta-lactamase that is found in Pseudomonas aeruginosa. PMID:11384532 VEB-16 VCC-1 is a Class A carbapenemase isolated from Vibrio cholerae and exhibits resistance to penicillins, carbapenems and monobactam antibiotics. VCC-1 antibiotic_resistance ARO:3003713 VCC-1 ARO:3003713 VCC-1 is a Class A carbapenemase isolated from Vibrio cholerae and exhibits resistance to penicillins, carbapenems and monobactam antibiotics. PMID:26824956 VCC-1 PEDO-2 is a subclass B3 metallo-beta lactamase isolated from Pedobacter borealis exhibiting carbapenem resistance. PEDO-2 antibiotic_resistance ARO:3003714 PEDO-2 ARO:3003714 PEDO-2 is a subclass B3 metallo-beta lactamase isolated from Pedobacter borealis exhibiting carbapenem resistance. PMID:26482314 PEDO-2 PEDO-3 is a class B1 metallo-beta lactamase isolated from Pedobacter kyungheensis exhibiting resistance to carbapenems. PEDO-3 antibiotic_resistance ARO:3003715 PEDO-3 ARO:3003715 PEDO-3 is a class B1 metallo-beta lactamase isolated from Pedobacter kyungheensis exhibiting resistance to carbapenems. PMID:26482314 PEDO-3 CPS-1 is a subclass B3 metallo-beta lactamase isolated from Chyseobacterium piscium exhibiting carbapenem resistance. B3CSP-1 CPS-1 antibiotic_resistance ARO:3003716 CPS-1 ARO:3003716 CPS-1 is a subclass B3 metallo-beta lactamase isolated from Chyseobacterium piscium exhibiting carbapenem resistance. PMID:26666948 CPS-1 ESP-1 is a subclass B3 metallo-beta lactamase isolated from Epilithonimonas tenax conferring resistance to carbapenems. ESP-1 antibiotic_resistance ARO:3003717 ESP-1 ARO:3003717 ESP-1 is a subclass B3 metallo-beta lactamase isolated from Epilithonimonas tenax conferring resistance to carbapenems. PMID:26482314 ESP-1 MSI-1 is a subclass B3 metallo-beta lactamase isolated from Massilia oculi conferring resistance to carbapenems. MSI-1 antibiotic_resistance ARO:3003718 MSI-1 ARO:3003718 MSI-1 is a subclass B3 metallo-beta lactamase isolated from Massilia oculi conferring resistance to carbapenems. PMID:26482314 MSI-1 MSI-OXA is an OXA-85-like class D beta lactamase isolated from Massilia oculi. MSI-OXA antibiotic_resistance ARO:3003719 MSI-OXA ARO:3003719 MSI-OXA is an OXA-85-like class D beta lactamase isolated from Massilia oculi. PMID:26482314 MSI-OXA SPG-1 is a subclass B3 metallo-beta lactamase isolated from Sphingomonas sp. SPG-1 antibiotic_resistance ARO:3003720 SPG-1 ARO:3003720 SPG-1 is a subclass B3 metallo-beta lactamase isolated from Sphingomonas sp. PMID:26482314 SPG-1 This inducible cluster confers high resistance to vancomycin and intermediate resistance to teicoplanin. It achieves this through peptidoglycan restructuring with its VanA ligase homologue, VanI, causing the precursurs to end in D-Ala-D-Lac. The cluster uniquely contains murF, the final enzyme in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. The VanI gene cluster has been found in chromosomal DNA. Gene orientation: vanSRIWK-murFvanX. vanI_cluster antibiotic_resistance ARO:3003722 glycopeptide resistance gene cluster VanI ARO:3003722 This inducible cluster confers high resistance to vancomycin and intermediate resistance to teicoplanin. It achieves this through peptidoglycan restructuring with its VanA ligase homologue, VanI, causing the precursurs to end in D-Ala-D-Lac. The cluster uniquely contains murF, the final enzyme in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. The VanI gene cluster has been found in chromosomal DNA. Gene orientation: vanSRIWK-murFvanX. PMID:16513756 PMID:19414574 PMID:25042042 vanI_cluster VanI is a D-Ala-D-Lac ligase that reduces vancomycin binding affinity, helping to confer vancomycin resistance as part of the VanI resistance gene cluster in Desulfitobacterium spp. and Desulfosporosinus spp. vanI antibiotic_resistance ARO:3003723 vanI ARO:3003723 VanI is a D-Ala-D-Lac ligase that reduces vancomycin binding affinity, helping to confer vancomycin resistance as part of the VanI resistance gene cluster in Desulfitobacterium spp. and Desulfosporosinus spp. PMID:19414574 PMID:25042042 vanI Also known as vanWI, is a vanW variant found in the vanI gene cluster. vanW-I vanWI vanW_in_vanI_cl antibiotic_resistance ARO:3003724 vanW gene in vanI cluster ARO:3003724 Also known as vanWI, is a vanW variant found in the vanI gene cluster. PMID:16513756 PMID:19414574 vanW_in_vanI_cl Also known as vanXI, is a vanX variant found in the vanI glycopeptide resistance gene cluster. It is a D-Ala-D-Ala dipeptidase. vanX-I vanXI vanX_in_vanI_cl antibiotic_resistance ARO:3003725 vanX gene in vanI cluster ARO:3003725 Also known as vanXI, is a vanX variant found in the vanI glycopeptide resistance gene cluster. It is a D-Ala-D-Ala dipeptidase. PMID:25042042 vanX_in_vanI_cl Also known as vanSI, is a vanS variant found in the vanI gene cluster; it is a histidine kinase. vanS-I vanSI vanS_in_vanI_cl antibiotic_resistance ARO:3003726 vanS gene in vanI cluster ARO:3003726 Also known as vanSI, is a vanS variant found in the vanI gene cluster; it is a histidine kinase. PMID:16513756 PMID:19414574 vanS_in_vanI_cl Also known as vanKI, is a peptidoglycan bridge formation protein also known as FemAB that is part of the vanI glycopeptide resistance gene cluster. vanK-I vanKI vanK_in_vanI_cl antibiotic_resistance ARO:3003727 vanK gene in vanI cluster ARO:3003727 Also known as vanKI, is a peptidoglycan bridge formation protein also known as FemAB that is part of the vanI glycopeptide resistance gene cluster. PMID:19414574 PMID:25042042 vanK_in_vanI_cl Also known as vanRI, is the regulatory transcriptional activator in the vanSR regulator within the vanI glycopeptide resistance gene cluster. vanR-I vanRI vanR_in_vanI_cl antibiotic_resistance ARO:3003728 vanR gene in vanI cluster ARO:3003728 Also known as vanRI, is the regulatory transcriptional activator in the vanSR regulator within the vanI glycopeptide resistance gene cluster. PMID:19414574 PMID:25042042 vanR_in_vanI_cl Point mutations to the isoleucyl-tRNA synthetase (ileS) in Staphylococcus aureus that confer resistance to mupirocin. Saur_ileS_MUP antibiotic_resistance ARO:3003729 Staphylococcus aureus ileS with mutation conferring resistance to mupirocin ARO:3003729 Point mutations to the isoleucyl-tRNA synthetase (ileS) in Staphylococcus aureus that confer resistance to mupirocin. PMID:11796355 Saur_ileS_MUP Bifidobacteria have an intrinsically resistant form of ileS (isoleucyl-tRNA synthetase) that confers resistance to mupirocin. Bbif_ileS_MUP antibiotic_resistance ARO:3003730 Bifidobacterium bifidum ileS conferring resistance to mupirocin ARO:3003730 Bifidobacteria have an intrinsically resistant form of ileS (isoleucyl-tRNA synthetase) that confers resistance to mupirocin. PMID:21421794 Bbif_ileS_MUP A specific fusidic acid resistance gene conferring intrinsic resistance in the bacteria Staphylococcus saprophyticus. FusD behaves by causing dissociation of EF-G from the ribosome thus counteracting the action of Fusidic acid. It is considered a FusB-type protein. fusD antibiotic_resistance ARO:3003731 fusD ARO:3003731 A specific fusidic acid resistance gene conferring intrinsic resistance in the bacteria Staphylococcus saprophyticus. FusD behaves by causing dissociation of EF-G from the ribosome thus counteracting the action of Fusidic acid. It is considered a FusB-type protein. PMID:17325218 fusD FusC is a fusidic acid resistance gene enabling ribosomal translocase EF-G dissociation from the ribosome that has been detected in Staphylococcus aureus and Staphylococcus intermedius. Its mechanism is believed to be similar to fusB due to its high level of sequence homology. It is considered a FusB-type protein. fusC antibiotic_resistance ARO:3003733 fusC ARO:3003733 FusC is a fusidic acid resistance gene enabling ribosomal translocase EF-G dissociation from the ribosome that has been detected in Staphylococcus aureus and Staphylococcus intermedius. Its mechanism is believed to be similar to fusB due to its high level of sequence homology. It is considered a FusB-type protein. PMID:17325218 fusC Antibiotic resistant fusA is caused by mutations to the elongation factor G (EF-G) and confers resistance to fusidic acid. antibiotic_resistance ARO:3003734 antibiotic resistant fusA ARO:3003734 Antibiotic resistant fusA is caused by mutations to the elongation factor G (EF-G) and confers resistance to fusidic acid. PMID:19289529 The mutations to this gene are involved in altering the translation elongation factor G (EF-G) in association with the ribosome to prevent fusidic acid from binding EF-G and preventing translation. Saur_fusA_FA antibiotic_resistance ARO:3003735 Staphylococcus aureus fusA with mutation conferring resistance to fusidic acid ARO:3003735 The mutations to this gene are involved in altering the translation elongation factor G (EF-G) in association with the ribosome to prevent fusidic acid from binding EF-G and preventing translation. PMID:11309125 PMID:12519196 PMID:19289529 PMID:20430787 PMID:20566766 PMID:33353175 Saur_fusA_FA Antibiotic resistant fusE is caused by mutations in a region of the rplF gene encoding riboprotein L6, and confers resistance to fusidic acid. antibiotic_resistance ARO:3003736 antibiotic resistant fusE ARO:3003736 Antibiotic resistant fusE is caused by mutations in a region of the rplF gene encoding riboprotein L6, and confers resistance to fusidic acid. PMID:19289529 The mutations to the rplF gene encoding riboprotein L6 have been shown to cause fusidic acid resistance, demonstrating a potential secondary site of action of the antibiotic that is blocked through these mutations. Several types of mutations have been identified that cause resistance, including SNPs, frameshift mutations and early stop codons. 50S ribosomal subunit protein L6 Saur_fusE_FA rplF antibiotic_resistance ARO:3003737 Staphylococcus aureus fusE with mutation conferring resistance to fusidic acid ARO:3003737 The mutations to the rplF gene encoding riboprotein L6 have been shown to cause fusidic acid resistance, demonstrating a potential secondary site of action of the antibiotic that is blocked through these mutations. Several types of mutations have been identified that cause resistance, including SNPs, frameshift mutations and early stop codons. PMID:17923494 PMID:19289529 PMID:20430787 PMID:20729356 Saur_fusE_FA mphE is a macrolide phosphotransferase and resistance gene identified on a plasmid, pRSB105. mphE antibiotic_resistance ARO:3003741 mphE ARO:3003741 mphE is a macrolide phosphotransferase and resistance gene identified on a plasmid, pRSB105. PMID:17261525 PMID:29317655 mphE The mphG gene encodes a macrolide 2'-phosphotransferase found in Photobacterium damselae sharing sequence similarity to mphA in E. coli. mphG antibiotic_resistance ARO:3003742 mphG ARO:3003742 The mphG gene encodes a macrolide 2'-phosphotransferase found in Photobacterium damselae sharing sequence similarity to mphA in E. coli. PMID:25765542 PMID:29317655 mphG vatF is a streptogramin A acetyl transferase gene isolated from the chromosome of Yersinia enterocolitica. vatF antibiotic_resistance ARO:3003744 vatF ARO:3003744 vatF is a streptogramin A acetyl transferase gene isolated from the chromosome of Yersinia enterocolitica. PMID:10722489 vatF mef(C) is a macrolide efflux gene isolated from a plasmid in Photobacterium damselae. mef(C) mefC antibiotic_resistance ARO:3003745 mef(C) ARO:3003745 mef(C) is a macrolide efflux gene isolated from a plasmid in Photobacterium damselae. PMID:22446310 mef(C) OptrA is a member of the ABC-F protein subfamily that confers resistance to oxazolidinones. The gene encoding the protein was originally isolated from a plasmid in Enterococcus faecalis and Enterococcus faecium. optrA antibiotic_resistance ARO:3003746 optrA ARO:3003746 OptrA is a member of the ABC-F protein subfamily that confers resistance to oxazolidinones. The gene encoding the protein was originally isolated from a plasmid in Enterococcus faecalis and Enterococcus faecium. PMID:25977397 optrA oleC is an ABC transporter isolated from Streptomyces antibioticus and is involved in oleandomycin secretion. oleC antibiotic_resistance ARO:3003748 oleC ARO:3003748 oleC is an ABC transporter isolated from Streptomyces antibioticus and is involved in oleandomycin secretion. PMID:8326867 oleC salA is an ABC-F subfamily protein gene isolated from the chromosome of Mammaliicoccus sciuri conferring resistance to lincosamides and streptogramins. sal(A) salA antibiotic_resistance ARO:3003749 salA ARO:3003749 salA is an ABC-F subfamily protein gene isolated from the chromosome of Mammaliicoccus sciuri conferring resistance to lincosamides and streptogramins. PMID:24687494 PMID:25891423 salA nfsA encodes the major oxygen-insesitive nitroreductase in E. coli. The first step of resistance to nitrofurazone is mutation of nfsA. Ecol_nfsA_NIT antibiotic_resistance ARO:3003751 Escherichia coli nfsA mutations conferring resistance to nitrofurantoin ARO:3003751 nfsA encodes the major oxygen-insesitive nitroreductase in E. coli. The first step of resistance to nitrofurazone is mutation of nfsA. PMID:15684426 PMID:18544599 PMID:26552976 Ecol_nfsA_NIT The nfsA-encoded nitroreductase is the major oxygen-insensitive nitroreductase present in E. coli. NfsA uses only NADPH and has broad electron acceptor specificity. Mutations in nfsA cause resistance to nitrofurazone and furazolidone. Resistance to nitrofurantoin via mutation of nfsA reduces the fitness of clinical isolates of E. coli. antibiotic_resistance ARO:3003754 antibiotic resistant nfsA ARO:3003754 The nfsA-encoded nitroreductase is the major oxygen-insensitive nitroreductase present in E. coli. NfsA uses only NADPH and has broad electron acceptor specificity. Mutations in nfsA cause resistance to nitrofurazone and furazolidone. Resistance to nitrofurantoin via mutation of nfsA reduces the fitness of clinical isolates of E. coli. PMID:15684426 PMID:18544599 PMID:338576 PMID:9791100 The nsfB gene encodes a minor oxygen-insensitive nitroreductase. NfsB reduces a broad range of nitroaromatic compounds including the antibiotics nitrofurazone and nitrofurantoin. NfsB is a flavin mononucleotide (FMN)-containing protein and uses both NADH and NADPH as a source of reducing equivalents. Mutations in nfsB lead to increased resistance to nitrofurazone and furazolidone in an nfsA mutant background. antibiotic_resistance ARO:3003755 Antibiotic resistant nfsB ARO:3003755 The nsfB gene encodes a minor oxygen-insensitive nitroreductase. NfsB reduces a broad range of nitroaromatic compounds including the antibiotics nitrofurazone and nitrofurantoin. NfsB is a flavin mononucleotide (FMN)-containing protein and uses both NADH and NADPH as a source of reducing equivalents. Mutations in nfsB lead to increased resistance to nitrofurazone and furazolidone in an nfsA mutant background. PMID:338576 PMID:7011517 PMID:8947835 PMID:9791100 nfsB encodes the minor oxygen-insesitive nitroreductase in E. coli. The first step of resistance to nitrofurazone is mutation of nfsA, while the increased resistance associated with second step mutants is a consequence of nfsB mutation. Ecol_nfsB_NIT antibiotic_resistance ARO:3003756 Escherichia coli nfsB with mutation conferring resistance to nitrofurantoin ARO:3003756 nfsB encodes the minor oxygen-insesitive nitroreductase in E. coli. The first step of resistance to nitrofurazone is mutation of nfsA, while the increased resistance associated with second step mutants is a consequence of nfsB mutation. PMID:18544599 PMID:26552976 PMID:9791100 Ecol_nfsB_NIT Cardiolipin synthase (cls) is an inner membrane protein involved in membrane synthesis and phosopholipid metabolism, with mutations to the gene being capable of conferring daptomycin resistance. Efae_cls_DAP antibiotic_resistance ARO:3003760 Enterococcus faecalis cls with mutation conferring resistance to daptomycin ARO:3003760 Cardiolipin synthase (cls) is an inner membrane protein involved in membrane synthesis and phosopholipid metabolism, with mutations to the gene being capable of conferring daptomycin resistance. PMID:23114777 PMID:23959318 PMID:24957825 Efae_cls_DAP eatAv is a mutated form of the wildtype eatA ABC-F subfamily protein isolated from Enterococcus faecium conferring resistance to lincosamides, streptogramin A's and pleuromutilins (LSaP phenotype). eatAv antibiotic_resistance ARO:3003761 eatAv ARO:3003761 eatAv is a mutated form of the wildtype eatA ABC-F subfamily protein isolated from Enterococcus faecium conferring resistance to lincosamides, streptogramin A's and pleuromutilins (LSaP phenotype). PMID:22366422 PMID:23836170 eatAv lnuE encodes a lincosamide resistance gene isolated from Streptococcus suis that was truncated by an ISEnfa5-cfr-ISEnfa5 segment insertion. It shares the closest sequence similarity to lnuA. linE lnuE antibiotic_resistance ARO:3003762 lnuE ARO:3003762 lnuE encodes a lincosamide resistance gene isolated from Streptococcus suis that was truncated by an ISEnfa5-cfr-ISEnfa5 segment insertion. It shares the closest sequence similarity to lnuA. PMID:24366733 lnuE Mechanism of antibiotic resistance conferred by deletion of gene (usually a porin). antibiotic_resistance ARO:3003764 resistance by absence ARO:3003764 mphM is a chromosomally-encoded macrolide phosphotransferases that inactivate 14-, 15- and 16-membered macrolides. mphM antibiotic_resistance ARO:3003767 mphM ARO:3003767 mphM is a chromosomally-encoded macrolide phosphotransferases that inactivate 14-, 15- and 16-membered macrolides. PMID:25059531 PMID:29317655 mphM Deletion of gene or gene product results in resistance. For example, deletion of a porin gene blocks drug from entering the cell. antibiotic_resistance ARO:3003768 gene conferring resistance via absence ARO:3003768 MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. A point mutation in the putative mprF synthase domain is associated with enhanced expression, increased synthesis and reduced daptomycin surface binding. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. Saur_mprF antibiotic_resistance ARO:3003769 Staphylococcus aureus mprF ARO:3003769 MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. A point mutation in the putative mprF synthase domain is associated with enhanced expression, increased synthesis and reduced daptomycin surface binding. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. PMID:14769468 PMID:19915718 PMID:20498310 Saur_mprF MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. Lmon_mprF antibiotic_resistance ARO:3003770 Listeria monocytogenes mprF ARO:3003770 MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. PMID:17042784 PMID:19915718 Lmon_mprF MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. Bsui_mprF antibiotic_resistance ARO:3003772 Brucella suis mprF ARO:3003772 MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. PMID:19915718 Bsui_mprF MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. Cper_mprF antibiotic_resistance ARO:3003773 Clostridium perfringens mprF ARO:3003773 MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. PMID:19915718 Cper_mprF MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. Saga_mprF antibiotic_resistance ARO:3003774 Streptococcus agalactiae mprF ARO:3003774 MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. PMID:19915718 Saga_mprF murA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Overexpression of murA through mutations such as Asp369Asn and Leu370Ile confers fosfomycin resistance. Extensive evidence has shown the significance of C115 mutations in conferring fosfomycin resistance since this residue represents a primary binding site for the antibiotic across many species. Ecol_murA_FOF antibiotic_resistance ARO:3003775 Escherichia coli murA with mutation conferring resistance to fosfomycin ARO:3003775 murA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Overexpression of murA through mutations such as Asp369Asn and Leu370Ile confers fosfomycin resistance. Extensive evidence has shown the significance of C115 mutations in conferring fosfomycin resistance since this residue represents a primary binding site for the antibiotic across many species. PMID:20071153 PMID:23143172 PMID:8281938 PMID:8664284 Ecol_murA_FOF murA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Overexpression of murA through mutations confers fosfomycin resistance. Saur_murA_FOF antibiotic_resistance ARO:3003776 Staphylococcus aureus murA with mutation conferring resistance to fosfomycin ARO:3003776 murA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Overexpression of murA through mutations confers fosfomycin resistance. PMID:26793179 Saur_murA_FOF murA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Mutations to the murA enzyme confers resistance to the antibiotic. Bbur_mur_FOF antibiotic_resistance ARO:3003777 Borreliella burgdorferi murA with mutation conferring resistance to fosfomycin ARO:3003777 murA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Mutations to the murA enzyme confers resistance to the antibiotic. PMID:21294548 Bbur_mur_FOF Mutations in the Mycolicibacterium smegmatis ndh gene that results in increased resistance to isoniazid. Msme_ndh_INH antibiotic_resistance ARO:3003778 Mycolicibacterium smegmatis ndh with mutation conferring resistance to isoniazid ARO:3003778 Mutations in the Mycolicibacterium smegmatis ndh gene that results in increased resistance to isoniazid. PMID:15673755 Msme_ndh_INH Mutations in the Mycobacterium tuberculosis variant bovis ndh gene that results in increased resistance to isoniazid. Mbov_ndh_INH Rv1854c antibiotic_resistance ARO:3003779 Mycobacterium tuberculosis variant bovis ndh with mutation conferring resistance to isoniazid ARO:3003779 Mutations in the Mycobacterium tuberculosis variant bovis ndh gene that results in increased resistance to isoniazid. PMID:15673755 Mbov_ndh_INH A heterocyclic antibiotic that targets mutant gyrA (type II topoisomerase) containing an S84L substitution, counteracting acquired quinolone resistance. It is effective against quinolone-resistant Gram-positive bacteria including S. aureus and E. faecalis. Due to its ability to counteract quinolone resistance by targeting the mutant form of the gyrA protein, it is classified as a reverse antibiotic (RA). ChEBI:203472 ChEMBL:CHEMBL1999880 PubChem:169159 antibiotic_resistance ARO:3003780 nybomycin ARO:3003780 A heterocyclic antibiotic that targets mutant gyrA (type II topoisomerase) containing an S84L substitution, counteracting acquired quinolone resistance. It is effective against quinolone-resistant Gram-positive bacteria including S. aureus and E. faecalis. Due to its ability to counteract quinolone resistance by targeting the mutant form of the gyrA protein, it is classified as a reverse antibiotic (RA). PMID:16589716 PMID:22534508 Mycobacterium tuberculosis murA confers intrinsic resistance to fosfomycin. The presence of an aspartic acid residue in place of the critical cysteine at position 117 that enables fosfomycin binding is believed to be responsible for this intrinsic resistance. Mtub_murA_FOF Rv1315 antibiotic_resistance ARO:3003784 Mycobacterium tuberculosis intrinsic murA conferring resistance to fosfomycin ARO:3003784 Mycobacterium tuberculosis murA confers intrinsic resistance to fosfomycin. The presence of an aspartic acid residue in place of the critical cysteine at position 117 that enables fosfomycin binding is believed to be responsible for this intrinsic resistance. PMID:10589726 PMID:22404577 Mtub_murA_FOF Chlamydia murA confers intrinsic resistance to fosfomycin. The presence of an aspartic acid residue in place of the critical cysteine at position 119 that enables fosfomycin binding is believed to be responsible for this intrinsic resistance. Ctra_murA_FOF antibiotic_resistance ARO:3003785 Chlamydia trachomatis intrinsic murA conferring resistance to fosfomycin ARO:3003785 Chlamydia murA confers intrinsic resistance to fosfomycin. The presence of an aspartic acid residue in place of the critical cysteine at position 119 that enables fosfomycin binding is believed to be responsible for this intrinsic resistance. PMID:12562791 Ctra_murA_FOF Inherent parC resistance to fluoroquinolone from an antibiotic producer. The presence of these genes confers self-resistance to the antibiotic it produces. antibiotic_resistance ARO:3003786 fluoroquinolone self resistant parC ARO:3003786 Inherent ParY resistant to aminocoumarin from an antibiotic producer. The presence of these genes confers self resistance to the antibiotic it produces. antibiotic_resistance ARO:3003787 aminocoumarin self resistant parY ARO:3003787 Point mutations that occur within the Bacillus subtilis pgsA gene resulting in resistance to daptomycin. Bsub_pgsA_DAP antibiotic_resistance ARO:3003788 Bacillus subtilis pgsA with mutation conferring resistance to daptomycin ARO:3003788 Point mutations that occur within the Bacillus subtilis pgsA gene resulting in resistance to daptomycin. PMID:12044378 PMID:21709092 Bsub_pgsA_DAP Campylobacter jejuni is a major bacterial infectious agent associated with gastroenteritis. Quinolone resistance is reportedly conferred by a single C-257-T nucleotide substitution in the gyrA gene. Cjej_gyrA_FLO antibiotic_resistance ARO:3003789 Campylobacter jejuni gyrA conferring resistance to fluoroquinolones ARO:3003789 Campylobacter jejuni is a major bacterial infectious agent associated with gastroenteritis. Quinolone resistance is reportedly conferred by a single C-257-T nucleotide substitution in the gyrA gene. PMID:26658311 Cjej_gyrA_FLO liaF is an accessory protein that acts as a negative regulator of liaRS signal transduction pathway. Mutations confer daptomycin resistance. Efac_liaF_DAP antibiotic_resistance ARO:3003790 Enterococcus faecium liaF mutant conferring daptomycin resistance ARO:3003790 liaF is an accessory protein that acts as a negative regulator of liaRS signal transduction pathway. Mutations confer daptomycin resistance. PMID:15793168 PMID:21899450 Efac_liaF_DAP liaS is a histidine kinase found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance. Efae_liaS_DAP antibiotic_resistance ARO:3003791 Enterococcus faecalis liaS mutant conferring daptomycin resistance ARO:3003791 liaS is a histidine kinase found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance. PMID:21899450 Efae_liaS_DAP liaR is a response regulator found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance. Efae_liaR_DAP antibiotic_resistance ARO:3003792 Enterococcus faecalis liaR mutant conferring daptomycin resistance ARO:3003792 liaR is a response regulator found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance. PMID:23959318 Efae_liaR_DAP Plasmid-mediated SPM metallo-beta-lactamase conferring resistance to carbapenem. Originally isolated from Pseudomonas aeruginosa. Responsible for carbapenem-resistant Pseudomonas aeruginosa (CRPA) outbreaks in Brazil. SPM-1 antibiotic_resistance ARO:3003793 SPM-1 ARO:3003793 Plasmid-mediated SPM metallo-beta-lactamase conferring resistance to carbapenem. Originally isolated from Pseudomonas aeruginosa. Responsible for carbapenem-resistant Pseudomonas aeruginosa (CRPA) outbreaks in Brazil. PMID:12407123 PMID:16239284 SPM-1 walK is the histidine kinase sensor of a two-component regulatory system controlling peptidoglycan metabolism through regulation of the expression of most of the peptidoglycan hydrolase genes. Mutations in the gene have been found that confer daptomycin resistance. Saur_walK_DAP vicK yycG antibiotic_resistance ARO:3003794 Staphylococcus aureus walK with mutation conferring resistance to daptomycin ARO:3003794 walK is the histidine kinase sensor of a two-component regulatory system controlling peptidoglycan metabolism through regulation of the expression of most of the peptidoglycan hydrolase genes. Mutations in the gene have been found that confer daptomycin resistance. PMID:16723576 PMID:23554895 Saur_walK_DAP Mutations to the walK gene, part of a cell wall metabolism 2-component regulatory system, confers resistance to antibiotics, specifically daptomycin. antibiotic_resistance ARO:3003795 daptomycin resistant walK ARO:3003795 Mutations to the walK gene, part of a cell wall metabolism 2-component regulatory system, confers resistance to antibiotics, specifically daptomycin. PMID:23554895 A class C beta-lactamase found in Acinetobacter baumannii that confers resistance to piperacillin and cefepime. Abau_ampC_BLA antibiotic_resistance ARO:3003796 Acinetobacter baumannii ampC beta-lactamase ARO:3003796 A class C beta-lactamase found in Acinetobacter baumannii that confers resistance to piperacillin and cefepime. PMID:21304033 Abau_ampC_BLA YybT has phosphodiesterase activity towards cyclic dinucleotides using a c-di-GMP hydrolyzing phosphodiesterase domain. Mutations to the gene confer resistance to daptomycin. Efae_YybT_DAP antibiotic_resistance ARO:3003797 Enterococcus faecalis YybT with mutation conferring daptomycin resistance ARO:3003797 YybT has phosphodiesterase activity towards cyclic dinucleotides using a c-di-GMP hydrolyzing phosphodiesterase domain. Mutations to the gene confer resistance to daptomycin. PMID:19901023 PMID:23959318 Efae_YybT_DAP Mutations to the YybT gene confers daptomycin resistance. antibiotic_resistance ARO:3003798 daptomycin resistant YybT ARO:3003798 Mutations to the YybT gene confers daptomycin resistance. PMID:19901023 PMID:23959318 gdpD is a glycerolphosphodiesterase whose mutations confer resistance to daptomycin. Efae_gdpD_DAP antibiotic_resistance ARO:3003800 Enterococcus faecalis gdpD with mutation conferring daptomycin resistance ARO:3003800 gdpD is a glycerolphosphodiesterase whose mutations confer resistance to daptomycin. PMID:23959318 Efae_gdpD_DAP Transmembrane protein which expels bicyclomycin from the cell, leading to bicyclomycin resistance. Identified in Pseudomonas aeruginosa strains responsible for outbreaks in Brazil, often appearing with blaSPM-1, another bicyclomycin resistance gene. bcr-1 antibiotic_resistance ARO:3003801 bcr-1 ARO:3003801 Transmembrane protein which expels bicyclomycin from the cell, leading to bicyclomycin resistance. Identified in Pseudomonas aeruginosa strains responsible for outbreaks in Brazil, often appearing with blaSPM-1, another bicyclomycin resistance gene. PMID:25085655 PMID:26093374 bcr-1 Mutations to the gdpD glycerolphosphodiesterase confer resistance to daptomycin. antibiotic_resistance ARO:3003802 daptomycin resistant gdpD ARO:3003802 Mutations to the gdpD glycerolphosphodiesterase confer resistance to daptomycin. PMID:23959318 agrA is an autoinducer in a peptide-quorum two-component regulatory system whose mutations confer daptomycin resistance. Saur_agrA_DAP accessory gene regulator protein A antibiotic_resistance ARO:3003803 Staphylococcus aureus agrA with mutation conferring resistance to daptomycin ARO:3003803 agrA is an autoinducer in a peptide-quorum two-component regulatory system whose mutations confer daptomycin resistance. PMID:22685286 PMID:23554895 Saur_agrA_DAP Mutations to the regulatory gene agrA confer daptomycin resistance. antibiotic_resistance ARO:3003804 daptomycin resistant agrA ARO:3003804 Mutations to the regulatory gene agrA confer daptomycin resistance. PMID:22685286 PMID:23554895 gshF is a bifunctional glutamate-cysteine ligase/ glutathione synthetase that when mutated, confers daptomycin resistance. Efae_gshF_DAP antibiotic_resistance ARO:3003805 Enterococcus faecalis gshF with mutation conferring daptomycin resistance ARO:3003805 gshF is a bifunctional glutamate-cysteine ligase/ glutathione synthetase that when mutated, confers daptomycin resistance. PMID:23959318 Efae_gshF_DAP Mutations to the glutathione synthetase gshF confers daptomycin resistance. antibiotic_resistance ARO:3003806 daptomycin resistant gshF ARO:3003806 Mutations to the glutathione synthetase gshF confers daptomycin resistance. PMID:23959318 AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance. The mutations associated with this model are specific to E. coli. Ecol_AcrR_MULT antibiotic_resistance ARO:3003807 Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime ARO:3003807 AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance. The mutations associated with this model are specific to E. coli. PMID:16189130 Ecol_AcrR_MULT carO is a transmembrane beta-barrel involved in the influx of carbapenem antibiotics in Acinetobacter baumannii. Disruption of the carO gene by distinct insertion elements results in a loss of carO expression causing resistance to carbapenem antibiotics. Homologs of carO have been identified in genera Acinetobacter, Moraxella and Psychrobacter. carO antibiotic_resistance ARO:3003808 carO ARO:3003808 carO is a transmembrane beta-barrel involved in the influx of carbapenem antibiotics in Acinetobacter baumannii. Disruption of the carO gene by distinct insertion elements results in a loss of carO expression causing resistance to carbapenem antibiotics. Homologs of carO have been identified in genera Acinetobacter, Moraxella and Psychrobacter. PMID:15793123 carO An outer member protein (OMP) found in Acinetobacter baumannii involved in the uptake of imipenem and basic amino acids. This porin is homologous to Pseudomonas aeruginosa OprD, which performs an identical function. Abau_OprD_IPM antibiotic_resistance ARO:3003809 Acinetobacter baumannii OprD conferring resistance to imipenem ARO:3003809 An outer member protein (OMP) found in Acinetobacter baumannii involved in the uptake of imipenem and basic amino acids. This porin is homologous to Pseudomonas aeruginosa OprD, which performs an identical function. PMID:16335991 Abau_OprD_IPM Natural producers of kirromycin and kirromycin-like antibiotics (i.e., kirrothrycin) possess self-resistance, which is classified here. antibiotic_resistance ARO:3003810 kirromycin self resistant EF-Tu ARO:3003810 Natural producers of kirromycin and kirromycin-like antibiotics (i.e., kirrothrycin) possess self-resistance, which is classified here. PMID:9043138 AdeC is the outer membrane factor of the AdeABC multidrug efflux complex. It can be replaced by other outer membrane channels, and is not essential for antibiotic resistance. adeC antibiotic_resistance ARO:3003811 adeC ARO:3003811 AdeC is the outer membrane factor of the AdeABC multidrug efflux complex. It can be replaced by other outer membrane channels, and is not essential for antibiotic resistance. PMID:21173183 adeC drmA is an uncharacterized 6-pass membrane protein, with mutations to the protein causing modest resistance to daptomycin. Efae_drmA_DAP antibiotic_resistance ARO:3003813 Enterococcus faecalis drmA with mutation conferring daptomycin resistance ARO:3003813 drmA is an uncharacterized 6-pass membrane protein, with mutations to the protein causing modest resistance to daptomycin. PMID:23959318 Efae_drmA_DAP Mutations to drmA confer daptomycin resistance. antibiotic_resistance ARO:3003814 daptomycin resistant drmA ARO:3003814 Mutations to drmA confer daptomycin resistance. PMID:23959318 YvlB is a putative target of the liaFSR signalling pathway, whose mutations confer daptomycin resistance. Efae_YvlB_DAP antibiotic_resistance ARO:3003815 Enterococcus faecalis YvlB with mutation conferring daptomycin resistance ARO:3003815 YvlB is a putative target of the liaFSR signalling pathway, whose mutations confer daptomycin resistance. PMID:23959318 Efae_YvlB_DAP Mutations to the putative liaFSR target YvlB confer daptomycin resistance. antibiotic_resistance ARO:3003816 daptomycin resistant YvlB ARO:3003816 Mutations to the putative liaFSR target YvlB confer daptomycin resistance. PMID:23959318 Mutations in the A subunit of DNA gyrase reduce its affinity for fluoroquinolones, thereby conferring resistance. Abau_gyrA_FLO antibiotic_resistance ARO:3003817 Acinetobacter baumannii gyrA conferring resistance to fluoroquinolones ARO:3003817 Mutations in the A subunit of DNA gyrase reduce its affinity for fluoroquinolones, thereby conferring resistance. PMID:15282231 PMID:21304033 Abau_gyrA_FLO Mutations in Acinetobacter baumannii parC that result in resistance to fluoroquinolones. Abau_parC_FLO antibiotic_resistance ARO:3003818 Acinetobacter baumannii parC conferring resistance to fluoroquinolones ARO:3003818 Mutations in Acinetobacter baumannii parC that result in resistance to fluoroquinolones. PMID:27175500 PMID:36010006 Abau_parC_FLO mgrB is a small transmembrane protein produced in the PhoPQ signalling system. It acts as a negative regulator in this system. Inactivation or down-regulation of mgrB confers colistin resistance by absence as shown in Klebsiella pneumoniae. YobG mgrB antibiotic_resistance ARO:3003820 mgrB ARO:3003820 mgrB is a small transmembrane protein produced in the PhoPQ signalling system. It acts as a negative regulator in this system. Inactivation or down-regulation of mgrB confers colistin resistance by absence as shown in Klebsiella pneumoniae. PMID:25190723 mgrB BAL30072 is a monocyclic beta-lactam antibiotic belonging to the sulfactams. BAL30072 was found to trigger the spheroplasting and lysis of Escherichia coli rather than the formation of extensive filaments. ChEMBL:CHEMBL1256967 PubChem:52942440 antibiotic_resistance ARO:3003821 BAL30072 ARO:3003821 BAL30072 is a monocyclic beta-lactam antibiotic belonging to the sulfactams. BAL30072 was found to trigger the spheroplasting and lysis of Escherichia coli rather than the formation of extensive filaments. PMID:20308379 PMID:23449829 Battacin is a cationic lipopeptide antibiotic produced from a Paenibacillus tianmuensis soil isolate. Battacin kills bacteria in vitro and has potent activity against Gram-negative bacteria, including multidrug-resistant and extremely drug-resistant clinical isolates. The bactericidal kinetics of battacin correlate with the depolarization of the cell membrane, suggesting that battacin kills bacteria by disrupting the cytoplasmic membrane. octapeptin B5 antibiotic_resistance ARO:3003822 battacin ARO:3003822 Battacin is a cationic lipopeptide antibiotic produced from a Paenibacillus tianmuensis soil isolate. Battacin kills bacteria in vitro and has potent activity against Gram-negative bacteria, including multidrug-resistant and extremely drug-resistant clinical isolates. The bactericidal kinetics of battacin correlate with the depolarization of the cell membrane, suggesting that battacin kills bacteria by disrupting the cytoplasmic membrane. PMID:22183171 Benzalkonium chloride is a type of cationic surfactant. It is an organic salt called a quaternary ammonium compound. It has three main categories of use: as a biocide, a cationic surfactant, and as a phase transfer agent. CAS:8001-54-5 ChEBI:3020 ChEMBL:CHEMBL502109 PubChem:2330 8001-54-5 Benzalkonium D00857 Zephiran chloride antibiotic_resistance ARO:3003823 benzalkonium chloride ARO:3003823 Benzalkonium chloride is a type of cationic surfactant. It is an organic salt called a quaternary ammonium compound. It has three main categories of use: as a biocide, a cationic surfactant, and as a phase transfer agent. PMID:9079913 An alanyl-tRNA synthetase conferring resistance to novobiocin in Escherichia coli. Sequence data unavailable. antibiotic_resistance ARO:3003830 Aminocoumarin resistant alaS ARO:3003830 An alanyl-tRNA synthetase conferring resistance to novobiocin in Escherichia coli. Sequence data unavailable. PMID:10217798 Temocillin is a beta-lactamase resistant carboxypenicillin. It is primarily used for the treatment of multiple drug resistant, Gram-negative bacteria, specifically Enterobacteriaceae. CAS:66148-78-5 ChEBI:51817 ChEMBL:CHEMBL1276310 PubChem:171758 BRL 17421 Temocilline Temocillinum antibiotic_resistance ARO:3003831 temocillin ARO:3003831 Temocillin is a beta-lactamase resistant carboxypenicillin. It is primarily used for the treatment of multiple drug resistant, Gram-negative bacteria, specifically Enterobacteriaceae. PMID:22115539 PMID:22294983 Ticarcillin is a carboxypenicillin used for the treatment of Gram-negative bacteria, particularly P. aeruginosa. Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis, when the bacteria try to divide, causing cell death. CAS:34787-01-4 ChEBI:9587 ChEMBL:CHEMBL1449 PubChem:36921 Ticarcilina Ticarcilline Ticarcillinum antibiotic_resistance ARO:3003832 ticarcillin ARO:3003832 Ticarcillin is a carboxypenicillin used for the treatment of Gram-negative bacteria, particularly P. aeruginosa. Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis, when the bacteria try to divide, causing cell death. PMID:21504594 PMID:22252797 Clostridioides difficile and Escherichia coli multidrug efflux transporter with antiporter function. Confers resistance to fluoroquinolones in E. coli and acriflavin in Clostridioides difficile. cdeA antibiotic_resistance ARO:3003835 cdeA ARO:3003835 Clostridioides difficile and Escherichia coli multidrug efflux transporter with antiporter function. Confers resistance to fluoroquinolones in E. coli and acriflavin in Clostridioides difficile. PMID:15383161 cdeA qacH is a subunit of the qac multidrug efflux pump in Staphylococcus saprophyticus. qacH antibiotic_resistance ARO:3003836 qacH ARO:3003836 qacH is a subunit of the qac multidrug efflux pump in Staphylococcus saprophyticus. PMID:9631545 qacH GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and, in situations where GadX is missing, activates gadA and gadBC. YhiW gadW antibiotic_resistance ARO:3003838 gadW ARO:3003838 GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and, in situations where GadX is missing, activates gadA and gadBC. PMID:12446650 PMID:16980449 gadW Mrx is part of the macrolide inactivation gene cluster in Aeromonas hydrophila. Mrx antibiotic_resistance ARO:3003839 Mrx ARO:3003839 Mrx is part of the macrolide inactivation gene cluster in Aeromonas hydrophila. PMID:16339607 Mrx Positive regulator of gene expression in the cysteine regulon. cysB mutants confer resistance to novobiocin, an aminocoumarin antibiotic, in Escherichia coli. Sequence data unavailable. antibiotic_resistance ARO:3003840 aminocoumarin resistant cysB ARO:3003840 Positive regulator of gene expression in the cysteine regulon. cysB mutants confer resistance to novobiocin, an aminocoumarin antibiotic, in Escherichia coli. Sequence data unavailable. PMID:1886615 kdpE is a transcriptional activator that is part of the two-component system KdpD/KdpE that is studied for its regulatory role in potassium transport and has been identified as an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. kdpE regulates a range of virulence loci through direct promoter binding. kdpE antibiotic_resistance ARO:3003841 kdpE ARO:3003841 kdpE is a transcriptional activator that is part of the two-component system KdpD/KdpE that is studied for its regulatory role in potassium transport and has been identified as an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. kdpE regulates a range of virulence loci through direct promoter binding. PMID:12618449 PMID:23555240 kdpE MUS-2 is a chromosome-encoded beta-lactamase from Myroides odoratimimus. MUS-2 antibiotic_resistance ARO:3003842 MUS-2 ARO:3003842 MUS-2 is a chromosome-encoded beta-lactamase from Myroides odoratimimus. PMID:26257915 MUS-2 leuO, a LysR family transcription factor, exists in a wide variety of bacteria of the family Enterobacteriaceae and is involved in the regulation of as yet unidentified genes affecting the stress response and pathogenesis expression. LeuO is also an activator of the MdtNOP efflux pump. leuO antibiotic_resistance ARO:3003843 leuO ARO:3003843 leuO, a LysR family transcription factor, exists in a wide variety of bacteria of the family Enterobacteriaceae and is involved in the regulation of as yet unidentified genes affecting the stress response and pathogenesis expression. LeuO is also an activator of the MdtNOP efflux pump. PMID:19429622 PMID:21883529 leuO mfd dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. The Mfd (mutation frequency decline) protein, also known as transcription-repair coupling factor, is responsible for ATP-dependent removal of stalled RNA polymerase from DNA lesions by inducing forward movement of the RNA polymerase and subsequent recruitment of nucleotide excision repair machinery to the sites of the lesions. mfd antibiotic_resistance ARO:3003844 mfd ARO:3003844 mfd dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. The Mfd (mutation frequency decline) protein, also known as transcription-repair coupling factor, is responsible for ATP-dependent removal of stalled RNA polymerase from DNA lesions by inducing forward movement of the RNA polymerase and subsequent recruitment of nucleotide excision repair machinery to the sites of the lesions. PMID:17239578 PMID:18535657 mfd ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis. antibiotic_resistance ARO:3003846 ADC beta-lactamase without carbapenemase activity ARO:3003846 ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis. PMID:15980372 ADC-1 is a beta-lactamase found in Acinetobacter baumannii. ADC-1 antibiotic_resistance ARO:3003847 ADC-1 ARO:3003847 ADC-1 is a beta-lactamase found in Acinetobacter baumannii. PMID:10639377 ADC-1 ADC-2 is a beta-lactamase found in Oligella urethralis. ADC-2 antibiotic_resistance ARO:3003848 ADC-2 ARO:3003848 ADC-2 is a beta-lactamase found in Oligella urethralis. PMID:12709319 ADC-2 ADC-3 is a beta-lactamase found in Acinetobacter baumannii. ADC-3 antibiotic_resistance ARO:3003849 ADC-3 ARO:3003849 ADC-3 is a beta-lactamase found in Acinetobacter baumannii. PMID:12709319 ADC-3 ADC-4 is a beta-lactamase found in Acinetobacter baumannii. ADC-4 antibiotic_resistance ARO:3003850 ADC-4 ARO:3003850 ADC-4 is a beta-lactamase found in Acinetobacter baumannii. PMID:12709319 ADC-4 ADC-5 is a beta-lactamase found in Acinetobacter pittii. ADC-5 antibiotic_resistance ARO:3003851 ADC-5 ARO:3003851 ADC-5 is a beta-lactamase found in Acinetobacter pittii. PMID:15047547 ADC-5 ADC-6 is a beta-lactamase found in Acinetobacter baumannii. ADC-6 antibiotic_resistance ARO:3003852 ADC-6 ARO:3003852 ADC-6 is a beta-lactamase found in Acinetobacter baumannii. PMID:14742218 ADC-6 ADC-7 is a beta-lactamase that is found in Acinetobacter baumannii. ADC-7 antibiotic_resistance ARO:3003853 ADC-7 ARO:3003853 ADC-7 is a beta-lactamase that is found in Acinetobacter baumannii. PMID:15980372 ADC-7 ADC-8 is a beta-lactamase found in Acinetobacter sp. ADC-8 antibiotic_resistance ARO:3003854 ADC-8 ARO:3003854 ADC-8 is a beta-lactamase found in Acinetobacter sp. PMID:17403709 ADC-8 ADC-10 is a beta-lactamase found in Acinetobacter baumannii. ADC-10 antibiotic_resistance ARO:3003855 ADC-10 ARO:3003855 ADC-10 ADC-12 is a beta-lactamase found in Acinetobacter pittii. ADC-12 antibiotic_resistance ARO:3003856 ADC-12 ARO:3003856 ADC-12 is a beta-lactamase found in Acinetobacter pittii. PMID:19029333 ADC-12 ADC-13 is a beta-lactamase found in Acinetobacter pittii. ADC-13 antibiotic_resistance ARO:3003857 ADC-13 ARO:3003857 ADC-13 is a beta-lactamase found in Acinetobacter pittii. PMID:19029333 ADC-13 ADC-14 is a beta-lactamase found in Acinetobacter pittii. ADC-14 antibiotic_resistance ARO:3003858 ADC-14 ARO:3003858 ADC-14 is a beta-lactamase found in Acinetobacter pittii. PMID:18065824 PMID:19029333 ADC-14 ADC-15 is a beta-lactamase found in Acinetobacter pittii. ADC-15 antibiotic_resistance ARO:3003859 ADC-15 ARO:3003859 ADC-15 is a beta-lactamase found in Acinetobacter pittii. PMID:19029333 ADC-15 ADC-16 is a beta-lactamase found in Acinetobacter pittii. ADC-16 antibiotic_resistance ARO:3003860 ADC-16 ARO:3003860 ADC-16 is a beta-lactamase found in Acinetobacter pittii. PMID:19029333 ADC-16 ADC-17 is a beta-lactamase found in Acinetobacter pittii. ADC-17 antibiotic_resistance ARO:3003861 ADC-17 ARO:3003861 ADC-17 is a beta-lactamase found in Acinetobacter pittii. PMID:19029333 ADC-17 ADC-18 is a beta-lactamase found in Acinetobacter pittii. ADC-18 antibiotic_resistance ARO:3003862 ADC-18 ARO:3003862 ADC-18 is a beta-lactamase found in Acinetobacter pittii. PMID:19029333 ADC-18 ADC-19 is a beta-lactamase found in Acinetobacter pittii. ADC-19 antibiotic_resistance ARO:3003863 ADC-19 ARO:3003863 ADC-19 is a beta-lactamase found in Acinetobacter pittii. PMID:19029333 ADC-19 ADC-20 is a beta-lactamase found in Acinetobacter pittii. ADC-20 antibiotic_resistance ARO:3003864 ADC-20 ARO:3003864 ADC-20 is a beta-lactamase found in Acinetobacter pittii. PMID:19029333 ADC-20 ADC-21 is a beta-lactamase found in Acinetobacter pittii. ADC-21 antibiotic_resistance ARO:3003865 ADC-21 ARO:3003865 ADC-21 is a beta-lactamase found in Acinetobacter pittii. PMID:19029333 ADC-21 ADC-22 is a beta-lactamase found in Acinetobacter pittii. ADC-22 antibiotic_resistance ARO:3003866 ADC-22 ARO:3003866 ADC-22 is a beta-lactamase found in Acinetobacter pittii. PMID:19029333 ADC-22 ADC-23 is a beta-lactamase found in Acinetobacter pittii. ADC-23 antibiotic_resistance ARO:3003867 ADC-23 ARO:3003867 ADC-23 is a beta-lactamase found in Acinetobacter pittii. PMID:19029333 ADC-23 ADC-25 is a beta-lactamase found in Acinetobacter baumannii. ADC-25 antibiotic_resistance ARO:3003868 ADC-25 ARO:3003868 ADC-25 is a beta-lactamase found in Acinetobacter baumannii. PMID:18077141 ADC-25 ADC-31 is a beta-lactamase found in Acinetobacter baumannii. ADC-31 antibiotic_resistance ARO:3003870 ADC-31 ARO:3003870 ADC-31 is a beta-lactamase found in Acinetobacter baumannii. PMID:22038960 ADC-31 ADC-39 is a beta-lactamase found in Acinetobacter baumannii. ADC-39 antibiotic_resistance ARO:3003871 ADC-39 ARO:3003871 ADC-39 is a beta-lactamase found in Acinetobacter baumannii. PMID:18765689 ADC-39 ADC-41 is a beta-lactamase found in Acinetobacter pittii. ADC-41 antibiotic_resistance ARO:3003872 ADC-41 ARO:3003872 ADC-41 is a beta-lactamase found in Acinetobacter pittii. PMID:20368407 ADC-41 ADC-42 is a beta-lactamase found in Acinetobacter pittii. ADC-42 antibiotic_resistance ARO:3003873 ADC-42 ARO:3003873 ADC-42 is a beta-lactamase found in Acinetobacter pittii. PMID:20368407 ADC-42 ADC-43 is a beta-lactamase found in Acinetobacter pittii. ADC-43 antibiotic_resistance ARO:3003874 ADC-43 ARO:3003874 ADC-43 is a beta-lactamase found in Acinetobacter pittii. PMID:20368407 ADC-43 Sequence variants of Enterococcus faecium elongation factor Tu that confer resistance to elfamycin antibiotics. antibiotic_resistance ARO:3003875 Enterococcus faecium EF-Tu mutants conferring resistance to elfamycin ARO:3003875 Sequence variants of Enterococcus faecium elongation factor Tu that confer resistance to elfamycin antibiotics. PMID:7989561 ADC-44 is a beta-lactamase found in Acinetobacter pittii. ADC-44 antibiotic_resistance ARO:3003876 ADC-44 ARO:3003876 ADC-44 is a beta-lactamase found in Acinetobacter pittii. PMID:20368407 ADC-44 ADC-56 is a beta-lactamase found in Acinetobacter baumannii. ADC-56 antibiotic_resistance ARO:3003878 ADC-56 ARO:3003878 ADC-56 is a beta-lactamase found in Acinetobacter baumannii. PMID:21788456 ADC-56 ADC-61 is a beta-lactamase found in Acinetobacter baumannii. ADC-61 antibiotic_resistance ARO:3003879 ADC-61 ARO:3003879 ADC-61 is a beta-lactamase found in Acinetobacter baumannii. PMID:26125919 ADC-61 ADC-74 is a beta-lactamase found in Acinetobacter baumannii. ADC-74 antibiotic_resistance ARO:3003880 ADC-74 ARO:3003880 ADC-74 is a beta-lactamase found in Acinetobacter baumannii. PMID:26824943 ADC-74 ADC-75 is a beta-lactamase found in Acinetobacter baumannii. ADC-75 antibiotic_resistance ARO:3003881 ADC-75 ARO:3003881 ADC-75 is a beta-lactamase found in Acinetobacter baumannii. PMID:26824943 ADC-75 ADC-76 is a beta-lactamase found in Acinetobacter baumannii. ADC-76 antibiotic_resistance ARO:3003882 ADC-76 ARO:3003882 ADC-76 is a beta-lactamase found in Acinetobacter baumannii. PMID:26824943 ADC-76 ADC-77 is a beta-lactamase found in Acinetobacter baumannii. ADC-77 antibiotic_resistance ARO:3003883 ADC-77 ARO:3003883 ADC-77 is a beta-lactamase found in Acinetobacter baumannii. PMID:26824943 ADC-77 ADC-78 is a beta-lactamase found in Acinetobacter baumannii. ADC-78 antibiotic_resistance ARO:3003884 ADC-78 ARO:3003884 ADC-78 is a beta-lactamase found in Acinetobacter baumannii. PMID:26824943 ADC-78 ADC-79 is a beta-lactamase found in Acinetobacter baumannii. ADC-79 antibiotic_resistance ARO:3003885 ADC-79 ARO:3003885 ADC-79 is a beta-lactamase found in Acinetobacter baumannii. PMID:26824943 ADC-79 ADC-80 is a beta-lactamase found in Acinetobacter baumannii. ADC-80 antibiotic_resistance ARO:3003886 ADC-80 ARO:3003886 ADC-80 is a beta-lactamase found in Acinetobacter baumannii. PMID:26824943 ADC-80 ADC-81 is a beta-lactamase found in Acinetobacter baumannii. ADC-81 antibiotic_resistance ARO:3003887 ADC-81 ARO:3003887 ADC-81 is a beta-lactamase found in Acinetobacter baumannii. PMID:26824943 ADC-81 ADC-82 is a beta-lactamase found in Acinetobacter baumannii. ADC-82 antibiotic_resistance ARO:3003888 ADC-82 ARO:3003888 ADC-82 is a beta-lactamase found in Acinetobacter baumannii. PMID:21398552 PMID:22952140 ADC-82 Point mutations to the active importer GlpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria. Ecol_GlpT_FOF antibiotic_resistance ARO:3003889 Escherichia coli GlpT with mutation conferring resistance to fosfomycin ARO:3003889 Point mutations to the active importer GlpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria. PMID:12936984 PMID:20071153 Ecol_GlpT_FOF Mutations to the active importer UhpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria. Ecol_UhpT_FOF antibiotic_resistance ARO:3003890 Escherichia coli UhpT with mutation conferring resistance to fosfomycin ARO:3003890 Mutations to the active importer UhpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria. PMID:20071153 Ecol_UhpT_FOF uhpA is a positive activator of the fosfomycin importer uhpT, thus mutations to uhpA confer fosfomycin resistance by reducing uhpT expression. Both knockout and amino acid substitution mutations have been found that confer resistance, with the Protein Knockout model describing the large, knockout mutations causing loss of function of the gene, and the Protein Variant model describing the amino acid substitutions. Ecol_uhpA_FOF antibiotic_resistance ARO:3003893 Escherichia coli uhpA with mutation conferring resistance to fosfomycin ARO:3003893 uhpA is a positive activator of the fosfomycin importer uhpT, thus mutations to uhpA confer fosfomycin resistance by reducing uhpT expression. Both knockout and amino acid substitution mutations have been found that confer resistance, with the Protein Knockout model describing the large, knockout mutations causing loss of function of the gene, and the Protein Variant model describing the amino acid substitutions. PMID:20071153 Ecol_uhpA_FOF Rm3 is a class B3 metallo-beta-lactamase isolated from a metagenomic soil sample in Yorkshire, United Kingdom, shown to confer resistance to clinically used penicillins, cephalosporins, and carbapenems. Rm3 antibiotic_resistance ARO:3003894 Rm3 ARO:3003894 Rm3 is a class B3 metallo-beta-lactamase isolated from a metagenomic soil sample in Yorkshire, United Kingdom, shown to confer resistance to clinically used penicillins, cephalosporins, and carbapenems. PMID:27431213 Rm3 Mutations in Pseudomonas aeruginosa PhoP of the two-component PhoPQ regulatory system. Presence of mutation confers resistance to colistin. Paer_PhoP_CST antibiotic_resistance ARO:3003895 Pseudomonas mutant PhoP conferring resistance to colistin ARO:3003895 Mutations in Pseudomonas aeruginosa PhoP of the two-component PhoPQ regulatory system. Presence of mutation confers resistance to colistin. PMID:24412662 Paer_PhoP_CST Mutations in Pseudomonas aeruginosa PhoQ of the two-component PhoPQ regulatory system. Presence of mutation confers resistance to colistin. Paer_PhoQ_CST antibiotic_resistance ARO:3003896 Pseudomonas mutant PhoQ conferring resistance to colistin ARO:3003896 Mutations in Pseudomonas aeruginosa PhoQ of the two-component PhoPQ regulatory system. Presence of mutation confers resistance to colistin. PMID:24412662 Paer_PhoQ_CST Tedizolid is a synthetic oxazolidinone antibiotic that is administered to the patient as a prodrug that is activated in vivo. It acts as an inhibitor of protein synthesis by binding the 50S subunit of the ribosome and preventing formation of the 70S initiation complex. It is active against Gram-positive pathogens. CAS:856866-72-3 ChEBI:82717 ChEMBL:CHEMBL1257051 PubChem:11234049 antibiotic_resistance ARO:3003897 tedizolid ARO:3003897 Tedizolid is a synthetic oxazolidinone antibiotic that is administered to the patient as a prodrug that is activated in vivo. It acts as an inhibitor of protein synthesis by binding the 50S subunit of the ribosome and preventing formation of the 70S initiation complex. It is active against Gram-positive pathogens. PMID:22324973 PMID:27904526 Lugdunin is a thiazolidine-containing cyclic peptide antibiotic isolated from nasal Staphylococcus lugnunensis that prohibits Staphylococcus aureus colony formation. It is a human commensal bacteria, indicating the potential for further antibiotic discoveries from human microbiota. ChEBI:133127 ChEMBL:CHEMBL5267022 PubChem:121596231 antibiotic_resistance ARO:3003898 lugdunin ARO:3003898 Lugdunin is a thiazolidine-containing cyclic peptide antibiotic isolated from nasal Staphylococcus lugnunensis that prohibits Staphylococcus aureus colony formation. It is a human commensal bacteria, indicating the potential for further antibiotic discoveries from human microbiota. PMID:27466123 PtsI (phosphoenolpyruvate-protein phosphotransferase) is involved in cyclic AMP synthesis, which regulates glpT expression. As a result, mutations to ptsI confer resistance to fosfomycin by affecting the regulation of fosfomycin import. Ecol_PtsI_FOF phosphoenolpyruvate-protein phosphotransferase antibiotic_resistance ARO:3003899 Escherichia coli PtsI with mutation conferring resistance to fosfomycin ARO:3003899 PtsI (phosphoenolpyruvate-protein phosphotransferase) is involved in cyclic AMP synthesis, which regulates glpT expression. As a result, mutations to ptsI confer resistance to fosfomycin by affecting the regulation of fosfomycin import. PMID:20071153 Ecol_PtsI_FOF CyaA (adenylate cyclase) is involved with the synthesis of cyclic AMP which regulates the fosfomycin transporter glpT. As a result, mutations to cyaA confer resistance to fosfomycin. Ecol_cyaA_FOF adenylate cyclase antibiotic_resistance ARO:3003900 Escherichia coli cyaA with mutation conferring resistance to fosfomycin ARO:3003900 CyaA (adenylate cyclase) is involved with the synthesis of cyclic AMP which regulates the fosfomycin transporter glpT. As a result, mutations to cyaA confer resistance to fosfomycin. PMID:14519998 PMID:20071153 Ecol_cyaA_FOF Mutations to the active importer GlpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria. Saur_GlpT_FOF antibiotic_resistance ARO:3003901 Staphylococcus aureus GlpT with mutation conferring resistance to fosfomycin ARO:3003901 Mutations to the active importer GlpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria. PMID:26793179 Saur_GlpT_FOF Mutations to the active importer UhpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria. Saur_UhpT_FOF antibiotic_resistance ARO:3003902 Staphylococcus aureus UhpT with mutation conferring resistance to fosfomycin ARO:3003902 Mutations to the active importer UhpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria. PMID:26793179 Saur_UhpT_FOF Thusin is a two-component lantibiotic isolated from B. thuringiensis strain BGSC 4BT1, exhibiting antimicrobial activity against several Gram-positive pathogens. Bacillus cereus, Listeria monocytogenes, Staphylococcus aureus (MRSA), Mammaliicoccus sciuri, Enterococcus faecalis, and Streptococcus pneumoniae have all shown susceptibility to Thusin, with inhibition activities greater than Vancomycin or other lantibiotics. antibiotic_resistance ARO:3003903 thusin ARO:3003903 Thusin is a two-component lantibiotic isolated from B. thuringiensis strain BGSC 4BT1, exhibiting antimicrobial activity against several Gram-positive pathogens. Bacillus cereus, Listeria monocytogenes, Staphylococcus aureus (MRSA), Mammaliicoccus sciuri, Enterococcus faecalis, and Streptococcus pneumoniae have all shown susceptibility to Thusin, with inhibition activities greater than Vancomycin or other lantibiotics. PMID:27486447 Formicin is a two-component broad-spectrum lantibiotic produced by Bacillus paralicheniformis APC 1576, exhibiting antimicrobial activity against several Gram-positive species, including Staphylococcus aureus, Clostridioides difficile and Listeria monocytogenes. CAS:50667-69-1 ChEBI:192837 ChEMBL:CHEMBL471524 PubChem:69365 antibiotic_resistance ARO:3003904 formicin ARO:3003904 Formicin is a two-component broad-spectrum lantibiotic produced by Bacillus paralicheniformis APC 1576, exhibiting antimicrobial activity against several Gram-positive species, including Staphylococcus aureus, Clostridioides difficile and Listeria monocytogenes. PMID:27450592 Aminoglycoside nucleotidyltransferase sequence from Staphylococcus aureus plasmid. ANT(4')-Ib aadD2 antibiotic_resistance ARO:3003905 ANT(4')-Ib ARO:3003905 Aminoglycoside nucleotidyltransferase sequence from Staphylococcus aureus plasmid. PMID:12654668 PMID:20585117 ANT(4')-Ib Cfr-like methyltransferase enzyme conferring resistance to multiple clinically relevant antibiotic classes. cipA antibiotic_resistance ARO:3003907 cipA ARO:3003907 Cfr-like methyltransferase enzyme conferring resistance to multiple clinically relevant antibiotic classes. PMID:23752511 cipA Chromosome-encoded gene conferring MLSB resistance. Identified from Helcococcus kunzii. Erm(47) antibiotic_resistance ARO:3003908 Erm(47) ARO:3003908 Chromosome-encoded gene conferring MLSB resistance. Identified from Helcococcus kunzii. PMID:27494920 Erm(47) A drug which binds to menaquinone in the bacterial cell membrane. Binding of Lysocin to menaquinone facilitates lysis of the cell. ChEBI:220095 PubChem:53373747 antibiotic_resistance ARO:3003915 Lysocin E ARO:3003915 A drug which binds to menaquinone in the bacterial cell membrane. Binding of Lysocin to menaquinone facilitates lysis of the cell. PMID:25485686 A molecule involved in electron transport in bacterial cell membrane. CAS:11032-49-8 ChEBI:16374 ChEMBL:CHEMBL4297659 PubChem:5287554 Vitamin K2 antibiotic_resistance ARO:3003916 menaquinone ARO:3003916 A molecule involved in electron transport in bacterial cell membrane. PMID:25485686 menA encodes a 1,4-dihydroxy-2-naphthoate octaprenyltransferase, with mutations to the protein conferring resistance to lysocin E. Saur_menA_LYS antibiotic_resistance ARO:3003917 Staphylococcus aureus menA with mutation conferring resistance to lysocin ARO:3003917 menA encodes a 1,4-dihydroxy-2-naphthoate octaprenyltransferase, with mutations to the protein conferring resistance to lysocin E. PMID:25485686 Saur_menA_LYS Plasmid-borne apramycin-resistant aminocyclitol acetyltransferase gene identified from bovine MRSA. apmA antibiotic_resistance ARO:3003918 apmA ARO:3003918 Plasmid-borne apramycin-resistant aminocyclitol acetyltransferase gene identified from bovine MRSA. PMID:20876371 PMID:33563840 PMID:37973888 apmA Lysocin family of peptide antibiotics isolated from Lysobacter spp. antibiotic_resistance ARO:3003919 lysocin ARO:3003919 Lysocin family of peptide antibiotics isolated from Lysobacter spp. PMID:25485686 A gene that produces the protein lipid A 4'-phosphatase. PGN-0524 pgpB antibiotic_resistance ARO:3003920 pgpB ARO:3003920 A gene that produces the protein lipid A 4'-phosphatase. PMID:20657724 pgpB oqxAB encodes for OqxAB, a plasmid-encoded efflux pump, which confer resistance to multiple agents including fluoroquinolones. oqxAB antibiotic_resistance ARO:3003921 oqxAB ARO:3003921 oqxAB encodes for OqxAB, a plasmid-encoded efflux pump, which confer resistance to multiple agents including fluoroquinolones. PMID:19528276 oqxAB RND efflux pump conferring resistance to fluoroquinolone. oqxA antibiotic_resistance ARO:3003922 oqxA ARO:3003922 RND efflux pump conferring resistance to fluoroquinolone. PMID:19528276 oqxA RND efflux pump conferring resistance to fluoroquinolone. oqxB antibiotic_resistance ARO:3003923 oqxB ARO:3003923 RND efflux pump conferring resistance to fluoroquinolone. PMID:19528276 oqxB Point mutation of Haemophilus parainfluenzae gyrA resulted in the lowered affinity between fluoroquinolones and GyrA. Thus, conferring resistance. Both Ser and Tyr are hydrophilic amino acids, however Tyr has an additional bulky hydrophobic group which could affect the interaction between the DNA gyrase with quinolones. Hpin_gyrA_FLO antibiotic_resistance ARO:3003924 Haemophilus parainfluenzae gyrA conferring resistance to fluoroquinolones ARO:3003924 Point mutation of Haemophilus parainfluenzae gyrA resulted in the lowered affinity between fluoroquinolones and GyrA. Thus, conferring resistance. Both Ser and Tyr are hydrophilic amino acids, however Tyr has an additional bulky hydrophobic group which could affect the interaction between the DNA gyrase with quinolones. PMID:27497656 Hpin_gyrA_FLO Point mutation of Haemophilus parainfluenzae parC resulted in the lowered affinity between fluoroquinolones and ParC. Thus, conferring resistance. Hpin_parC_FLO antibiotic_resistance ARO:3003925 Haemophilus parainfluenzae parC conferring resistance to fluoroquinolones ARO:3003925 Point mutation of Haemophilus parainfluenzae parC resulted in the lowered affinity between fluoroquinolones and ParC. Thus, conferring resistance. PMID:27497656 Hpin_parC_FLO Point mutations in Salmonella gyrA that confer resistance to Nalidixic acid, a fluoroquinolone antibiotic. These mutations have also been shown to reduce susceptibility to ciprofloxacin. Sent_gyrA_FLO antibiotic_resistance ARO:3003926 Salmonella enterica gyrA conferring resistance to fluoroquinolones ARO:3003926 Point mutations in Salmonella gyrA that confer resistance to Nalidixic acid, a fluoroquinolone antibiotic. These mutations have also been shown to reduce susceptibility to ciprofloxacin. PMID:27559761 PMID:27630841 Sent_gyrA_FLO Ceftolozane is a fifth-generation cephalosporin antibiotic developed for the treatment of infections with gram-negative bacteria that have become resistant to conventional antibiotics. CAS:689293-68-3 ChEBI:134719 ChEMBL:CHEMBL2103872 PubChem:53234134 Zerbaxa antibiotic_resistance ARO:3003927 ceftolozane ARO:3003927 Ceftolozane is a fifth-generation cephalosporin antibiotic developed for the treatment of infections with gram-negative bacteria that have become resistant to conventional antibiotics. PMID:27522066 Point mutation in Neisseria gonorrhoeae DNA gyrase subunit A. Decreases affinity between fluoroquinolone antibiotic molecule and gyrA, thereby conferring resistance to fluoroquinolone. Ngon_gyrA_FLO antibiotic_resistance ARO:3003928 Neisseria gonorrhoeae gyrA with mutations conferring resistance to fluoroquinolones ARO:3003928 Point mutation in Neisseria gonorrhoeae DNA gyrase subunit A. Decreases affinity between fluoroquinolone antibiotic molecule and gyrA, thereby conferring resistance to fluoroquinolone. PMID:27506605 PMID:30961546 PMID:38786196 Ngon_gyrA_FLO Point mutations in Neisseria gonorrhoeae parC protein that confer resistance to fluoroquinolone by reducing affinity to antibiotic binding site. Ngon_parC_FLO antibiotic_resistance ARO:3003929 Neisseria gonorrhoeae parC conferring resistance to fluoroquinolones ARO:3003929 Point mutations in Neisseria gonorrhoeae parC protein that confer resistance to fluoroquinolone by reducing affinity to antibiotic binding site. PMID:27506605 PMID:30961546 PMID:38786196 Ngon_parC_FLO rpsJ is a tetracycline resistance protein identified in Neisseria gonorrhoeae. Tetracycline resistance is conferred by binding to the ribosome as a 30S ribosomal protection protein. nusE rpsJ antibiotic_resistance ARO:3003930 rpsJ ARO:3003930 rpsJ is a tetracycline resistance protein identified in Neisseria gonorrhoeae. Tetracycline resistance is conferred by binding to the ribosome as a 30S ribosomal protection protein. PMID:27506605 rpsJ Point mutation in Capnocytophaga gingivalis that decreases binding affinity of fluoroquinolone antibiotics to gyrA, thereby conferring resistance. Cgin_gyrA_FLO antibiotic_resistance ARO:3003931 Capnocytophaga gingivalis gyrA conferring resistance to fluoroquinolones ARO:3003931 Point mutation in Capnocytophaga gingivalis that decreases binding affinity of fluoroquinolone antibiotics to gyrA, thereby conferring resistance. PMID:27531625 Cgin_gyrA_FLO Compounds and molecules that inhibit the action of antibiotic efflux proteins, thereby decreasing resistance caused by efflux pumps. antibiotic_resistance ARO:3003932 antibiotic efflux inhibitor ARO:3003932 Berberine is a benzylisoquinoline alkaloid shown to reduce MexXY-dependent antibiotic resistance of cephalosporins, macrolides, lincosamides and aminoglycosides in Pseudomonas, Burkholderia and Achromobacter. CAS:2086-83-1 ChEBI:16118 ChEMBL:CHEMBL295124 PubChem:2353 antibiotic_resistance ARO:3003933 Berberine ARO:3003933 Berberine is a benzylisoquinoline alkaloid shown to reduce MexXY-dependent antibiotic resistance of cephalosporins, macrolides, lincosamides and aminoglycosides in Pseudomonas, Burkholderia and Achromobacter. PMID:27547203 An aminomethylcycline antibiotic that targets 16s rRNA in gram positive and gram negative bacteria. ChEBI:177758 ChEMBL:CHEMBL1689772 PubChem:54697325 antibiotic_resistance ARO:3003936 Omadacycline ARO:3003936 An aminomethylcycline antibiotic that targets 16s rRNA in gram positive and gram negative bacteria. PMID:27669321 Point mutation in Neisseria meningititis PBP2 (penA) decreases affinity between beta-lactam antibiotic molecule and PBP2, thereby conferring resistance to beta-lactam. Nmen_PBP2_BLA antibiotic_resistance ARO:3003937 Neisseria meningititis PBP2 conferring resistance to beta-lactam ARO:3003937 Point mutation in Neisseria meningititis PBP2 (penA) decreases affinity between beta-lactam antibiotic molecule and PBP2, thereby conferring resistance to beta-lactam. PMID:16940068 PMID:18986991 PMID:25199775 PMID:25987627 PMID:26787702 PMID:27690121 Nmen_PBP2_BLA Mutations in PBP transpeptidases that change the affinity for penicillin thereby conferring resistance to penicillin antibiotics. antibiotic_resistance ARO:3003938 Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics ARO:3003938 Point mutations in Salmonella parC gene implicated in decreased susceptibility to fluoroquinolone antibiotics, primarily ciprofloxacin and nalidixic acid. Sent_parC_FLO antibiotic_resistance ARO:3003939 Salmonella enterica parC conferring resistance to fluoroquinolones ARO:3003939 Point mutations in Salmonella parC gene implicated in decreased susceptibility to fluoroquinolone antibiotics, primarily ciprofloxacin and nalidixic acid. PMID:27630841 Sent_parC_FLO Point mutations in Shigella flexneri gyrA observed to confer resistance to fluoroquinolone antibiotics. Sfle_gyrA_FLO antibiotic_resistance ARO:3003940 Shigella flexneri gyrA conferring resistance to fluoroquinolones ARO:3003940 Point mutations in Shigella flexneri gyrA observed to confer resistance to fluoroquinolone antibiotics. PMID:27620866 Sfle_gyrA_FLO Point mutation in parC conferring resistance to fluoroquinolone antibiotics in Shigella flexneri,. Sfle_parC_FLO antibiotic_resistance ARO:3003941 Shigella flexneri parC conferring resistance to fluoroquinolones ARO:3003941 Point mutation in parC conferring resistance to fluoroquinolone antibiotics in Shigella flexneri,. PMID:27620866 Sfle_parC_FLO AbcA is a multidrug resistant ABC transporter that confers resistance to methicillin, daptomycin, cefotaxime, and moenomycin. abcA antibiotic_resistance ARO:3003942 abcA ARO:3003942 AbcA is a multidrug resistant ABC transporter that confers resistance to methicillin, daptomycin, cefotaxime, and moenomycin. PMID:19800843 PMID:24509312 PMID:26160745 abcA EfrAB is a heterodimeric ABC transporter efflux pump found in Enterococcus faecalis and Enterococcus faecium that confers resistance to ciprofloxacin, erythromycin, rifampicin, quinupristine. antibiotic_resistance ARO:3003947 EfrAB ARO:3003947 EfrAB is a heterodimeric ABC transporter efflux pump found in Enterococcus faecalis and Enterococcus faecium that confers resistance to ciprofloxacin, erythromycin, rifampicin, quinupristine. PMID:14638474 PMID:25084670 efrA is a part of the EfrAB efflux pump, and both efrA and efrB are necessary to confer drug resistance. efrA antibiotic_resistance ARO:3003948 efrA ARO:3003948 efrA is a part of the EfrAB efflux pump, and both efrA and efrB are necessary to confer drug resistance. PMID:14638474 PMID:25084670 efrA efrB is a part of the EfrAB efflux pump, and both efrA and efrB are necessary to confer multidrug resistance. efrB antibiotic_resistance ARO:3003949 efrB ARO:3003949 efrB is a part of the EfrAB efflux pump, and both efrA and efrB are necessary to confer multidrug resistance. PMID:14638474 PMID:25084670 efrB MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A, a major component of the bacterial outer cell membrane, and is the only bacterial ABC transporter that is essential for cell viability. msbA antibiotic_resistance ARO:3003950 msbA ARO:3003950 MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A, a major component of the bacterial outer cell membrane, and is the only bacterial ABC transporter that is essential for cell viability. PMID:12195740 PMID:12358070 PMID:19678712 PMID:27499013 msbA Microcin J25 is a peptide antibiotic that inhibits transcription by bacterial RNA polymerase. MccJ25 is produced by Escherichia coli strains that harbor a plasmid-borne antibiotic-synthesis and antibiotic-export cassette, consisting of a gene for MccJ25 precursor (a 58 residue linear peptide), two genes for factors that process MccJ25 precursor into MccJ25, and one gene for export of MccJ25. ChEBI:203056 ChEMBL:CHEMBL1945674 PubChem:10793809 MccJ25 antibiotic_resistance ARO:3003951 microcin J25 ARO:3003951 Microcin J25 is a peptide antibiotic that inhibits transcription by bacterial RNA polymerase. MccJ25 is produced by Escherichia coli strains that harbor a plasmid-borne antibiotic-synthesis and antibiotic-export cassette, consisting of a gene for MccJ25 precursor (a 58 residue linear peptide), two genes for factors that process MccJ25 precursor into MccJ25, and one gene for export of MccJ25. PMID:15200952 YojI mediates resistance to the peptide antibiotic microcin J25 when it is expressed from a multicopy vector. YojI is capable of pumping out microcin molecules. The outer membrane protein TolC in addition to YojI is required for export of microcin J25 out of the cell. Microcin J25 is thus the first known substrate for YojI. YojI antibiotic_resistance ARO:3003952 YojI ARO:3003952 YojI mediates resistance to the peptide antibiotic microcin J25 when it is expressed from a multicopy vector. YojI is capable of pumping out microcin molecules. The outer membrane protein TolC in addition to YojI is required for export of microcin J25 out of the cell. Microcin J25 is thus the first known substrate for YojI. PMID:15866933 YojI hmrM is a multidrug efflux pump belonging to the MATE family and functions as a Na+/drug antiporter. hmrM antibiotic_resistance ARO:3003953 hmrM ARO:3003953 hmrM is a multidrug efflux pump belonging to the MATE family and functions as a Na+/drug antiporter. PMID:14695443 PMID:16614254 hmrM efmA is an MFS transporter permease in E. faecium. efmA antibiotic_resistance ARO:3003954 efmA ARO:3003954 efmA is an MFS transporter permease in E. faecium. PMID:19252300 efmA efpA is an MFS transporter found in Mycobacterium tuberculosis. efpA antibiotic_resistance ARO:3003955 efpA ARO:3003955 efpA is an MFS transporter found in Mycobacterium tuberculosis. PMID:15215089 PMID:21871582 PMID:9008277 efpA Amongst the diverse and potent biological activities of free fatty acids (FFAs) is the ability to kill or inhibit the growth of bacteria. The antibacterial properties of FFAs are used by many organisms to defend against parasitic or pathogenic bacteria. The prime target of FFA action is the cell membrane, where FFAs disrupt the electron transport chain and oxidative phosphorylation. Besides interfering with cellular energy production, FFA action may also result from the inhibition of enzyme activity, impairment of nutrient uptake, generation of peroxidation and auto-oxidation degradation products or direct lysis of bacterial cells. antibiotic_resistance ARO:3003956 antibacterial free fatty acids ARO:3003956 Amongst the diverse and potent biological activities of free fatty acids (FFAs) is the ability to kill or inhibit the growth of bacteria. The antibacterial properties of FFAs are used by many organisms to defend against parasitic or pathogenic bacteria. The prime target of FFA action is the cell membrane, where FFAs disrupt the electron transport chain and oxidative phosphorylation. Besides interfering with cellular energy production, FFA action may also result from the inhibition of enzyme activity, impairment of nutrient uptake, generation of peroxidation and auto-oxidation degradation products or direct lysis of bacterial cells. PMID:19956944 Palmitic acid is the most common saturated fatty acid found in animals, plants, and microorganisms. Palmitic acid is found to have antibacterial properties. CAS:57-10-3 ChEBI:15756 ChEMBL:CHEMBL82293 PubChem:985 Cetylic acid Hexadecanoic acid N-Hexadecanoic acid Palmitate antibiotic_resistance ARO:3003957 palmitic acid ARO:3003957 Palmitic acid is the most common saturated fatty acid found in animals, plants, and microorganisms. Palmitic acid is found to have antibacterial properties. PMID:10447892 PMID:11744302 PMID:19956944 Oleic acid is a fatty acid that occurs naturally in various animal and vegetable fats and oils. Oleic acid is found to have antibacterial activity, particularly in inhibiting the growth of several Gram-positive bacterial species. CAS:112-80-1 ChEBI:16196 ChEMBL:CHEMBL8659 PubChem:445639 Cis-9-Octadecenoic acid Cis-Oleic acid Elaidoic acid Oleate antibiotic_resistance ARO:3003958 oleic acid ARO:3003958 Oleic acid is a fatty acid that occurs naturally in various animal and vegetable fats and oils. Oleic acid is found to have antibacterial activity, particularly in inhibiting the growth of several Gram-positive bacterial species. PMID:10447892 PMID:10925024 PMID:18754790 PMID:19956944 PMID:393631 Linoleic acid is a polyunsaturated omega-6 fatty acid. Linoleic acid has been found to have antibacterial activity, particularly in inhibiting the growth of Gram-positive bacterial species. CAS:60-33-3 ChEBI:17351 ChEMBL:CHEMBL267476 PubChem:5280450 Linoleate Linolic acid Telfairic acid antibiotic_resistance ARO:3003959 linoleic acid ARO:3003959 Linoleic acid is a polyunsaturated omega-6 fatty acid. Linoleic acid has been found to have antibacterial activity, particularly in inhibiting the growth of Gram-positive bacterial species. PMID:10447892 PMID:10925024 PMID:19956944 PMID:93615 farAB is an MFS efflux pump found in gonococci that is involved in antibacterial fatty acid resistance. Moreover, expression of the tandemly linked farA and farB genes was positively associated with the presence of the MtrR transcriptional regulatory protein that normally downregulates the expression of mtrCDE. antibiotic_resistance ARO:3003960 farAB ARO:3003960 farAB is an MFS efflux pump found in gonococci that is involved in antibacterial fatty acid resistance. Moreover, expression of the tandemly linked farA and farB genes was positively associated with the presence of the MtrR transcriptional regulatory protein that normally downregulates the expression of mtrCDE. PMID:10447892 farA is the membrane fusion protein that is part of the farAB efflux pump. farA antibiotic_resistance ARO:3003961 farA ARO:3003961 farA is the membrane fusion protein that is part of the farAB efflux pump. PMID:10447892 farA farB is the cytoplasmic transporter protein that is part of the farAB efflux pump. farB corresponds to 3 loci in Pseudomonas aeruginosa PAO1 and 3 loci in Pseudomonas aeruginosa LESB58. farB antibiotic_resistance ARO:3003962 farB ARO:3003962 farB is the cytoplasmic transporter protein that is part of the farAB efflux pump. farB corresponds to 3 loci in Pseudomonas aeruginosa PAO1 and 3 loci in Pseudomonas aeruginosa LESB58. PMID:10447892 farB The Flo transporters can be plasmid- or chromosome-encoded. flo is an important determinant of florfenicol resistance in animal isolates of E. coli but is also found in human pathogens (e.g. Salmonella enterica and V. cholerae). antibiotic_resistance ARO:3003963 flo ARO:3003963 The Flo transporters can be plasmid- or chromosome-encoded. flo is an important determinant of florfenicol resistance in animal isolates of E. coli but is also found in human pathogens (e.g. Salmonella enterica and V. cholerae). PMID:10639375 PMID:11101601 PMID:15914491 hp1181 is a translocase that is part of the MFS efflux pump family. It is found in H. pylori and has role in the active efflux of antibiotics. hp1181 antibiotic_resistance ARO:3003964 hp1181 ARO:3003964 hp1181 is a translocase that is part of the MFS efflux pump family. It is found in H. pylori and has role in the active efflux of antibiotics. PMID:27303615 hp1181 hp1184 is a translocase that belongs to the MATE efflux pump family. It is found in H. pylori and is involved in the active efflux of antibiotics. hp1184 antibiotic_resistance ARO:3003965 hp1184 ARO:3003965 hp1184 is a translocase that belongs to the MATE efflux pump family. It is found in H. pylori and is involved in the active efflux of antibiotics. PMID:15793129 PMID:27303615 hp1184 Klebsiella pneumoniae outer membrane porin protein. In beta-lactam-resistant Klebsiella, this porin is often deleted, limiting diffusion of the antibiotic into the cell. Klebsiella strains expressing OmpK35 are often beta-lactam sensitive even in the presence of beta-lactamases because of an inefficient mechanism. Kpne_OmpK35 antibiotic_resistance ARO:3003966 Klebsiella pneumoniae OmpK35 ARO:3003966 Klebsiella pneumoniae outer membrane porin protein. In beta-lactam-resistant Klebsiella, this porin is often deleted, limiting diffusion of the antibiotic into the cell. Klebsiella strains expressing OmpK35 are often beta-lactam sensitive even in the presence of beta-lactamases because of an inefficient mechanism. PMID:27645385 Kpne_OmpK35 lfrA is involved in the active efflux of quinolones and is found in Mycobacteroides abscessus. lfrA antibiotic_resistance ARO:3003967 lfrA ARO:3003967 lfrA is involved in the active efflux of quinolones and is found in Mycobacteroides abscessus. PMID:8682782 lfrA Klebsiella pneumoniae outer membrane porin protein. In beta-lactam-resistant Klebsiella, this porin is often deleted, limiting diffusion of the antibiotic into the cell. Klebsiella strains expressing OmpK36 are often beta-lactam sensitive even in the presence of beta-lactamases because of an inefficient mechanism. Kpne_OmpK36 antibiotic_resistance ARO:3003968 Klebsiella pneumoniae OmpK36 ARO:3003968 Klebsiella pneumoniae outer membrane porin protein. In beta-lactam-resistant Klebsiella, this porin is often deleted, limiting diffusion of the antibiotic into the cell. Klebsiella strains expressing OmpK36 are often beta-lactam sensitive even in the presence of beta-lactamases because of an inefficient mechanism. PMID:27645385 Kpne_OmpK36 lmrP is a proton motive force-dependent drug transporter that is part of the MFS efflux pump family. lmrP antibiotic_resistance ARO:3003969 lmrP ARO:3003969 lmrP is a proton motive force-dependent drug transporter that is part of the MFS efflux pump family. PMID:10532389 PMID:11577166 PMID:7592810 lmrP Non-van ligases that synthesize D-Ala-D-Ala, the default cell wall precursor that makes a cell vulnerable to glycopeptide antibiotics. Mutations in the ddl gene can cause the production of nonfunctional/inactivated D-Ala-D-Ala ligases, which can render bacteria glycopeptide dependent depending on the presence of vancomycin resistance clusters. ddl antibiotic_resistance ARO:3003970 D-Ala-D-Ala ligase ARO:3003970 Non-van ligases that synthesize D-Ala-D-Ala, the default cell wall precursor that makes a cell vulnerable to glycopeptide antibiotics. Mutations in the ddl gene can cause the production of nonfunctional/inactivated D-Ala-D-Ala ligases, which can render bacteria glycopeptide dependent depending on the presence of vancomycin resistance clusters. PMID:11274474 PMID:16323116 ddl Variant of Erm(44)v isolated from Staphylococcus saprophyticus, confers resistance to lincosamide and macrolide antibiotics but not streptogramins. Erm(44)v antibiotic_resistance ARO:3003971 Erm(44)v ARO:3003971 Variant of Erm(44)v isolated from Staphylococcus saprophyticus, confers resistance to lincosamide and macrolide antibiotics but not streptogramins. PMID:27799208 Erm(44)v A clinically developed Macrolide antibiotic targeting gram positive and gram negative bacteria. ChEBI:230261 ChEMBL:CHEMBL1232510 PubChem:72734351 CEM-101 antibiotic_resistance ARO:3003972 Solithromycin ARO:3003972 A clinically developed Macrolide antibiotic targeting gram positive and gram negative bacteria. PMID:27909995 Point mutations in Cutibacterium acnes gyrA protein known to confer resistance to fluoroquinolone antibiotics. Cacn_gyrA_FLO antibiotic_resistance ARO:3003974 Cutibacterium acnes gyrA conferring resistance to fluoroquinolones ARO:3003974 Point mutations in Cutibacterium acnes gyrA protein known to confer resistance to fluoroquinolone antibiotics. PMID:27793740 Cacn_gyrA_FLO Antibiotic produced by Streptomyces pactum, considered a universal translation inhibitor. ChEBI:198890 ChEMBL:CHEMBL458512 PubChem:5289124 antibiotic_resistance ARO:3003975 pactamycin ARO:3003975 Antibiotic produced by Streptomyces pactum, considered a universal translation inhibitor. PMID:9398510 Point mutations in bacterial 16S rRNA that confer resistance to antibiotic pactamycin. antibiotic_resistance ARO:3003976 16S rRNA with mutation conferring resistance to pactamycin ARO:3003976 Point mutations in bacterial 16S rRNA that confer resistance to antibiotic pactamycin. PMID:9398510 Point mutations in Halobacterium 16S rRNA that confer resistance to pactamycin antibiotic. Hsal_16S_PAC antibiotic_resistance ARO:3003977 Halobacterium salinarum 16S rRNA mutation conferring resistance to pactamycin ARO:3003977 Point mutations in Halobacterium 16S rRNA that confer resistance to pactamycin antibiotic. PMID:9398510 Hsal_16S_PAC Point mutation in C. reinhardtii rrnS conferring resistance to streptomycin antibiotic. Crei_16rrnS_STR antibiotic_resistance ARO:3003978 Chlamydomonas reinhardtii 16S rRNA (rrnS) mutation conferring resistance to streptomycin ARO:3003978 Point mutation in C. reinhardtii rrnS conferring resistance to streptomycin antibiotic. PMID:2583478 Crei_16rrnS_STR A fluorocycline that acts to inhibit the bacterial ribosome. ChEBI:177804 ChEMBL:CHEMBL1951095 PubChem:54726192 7-fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline TP-434 antibiotic_resistance ARO:3003979 Eravacycline ARO:3003979 A fluorocycline that acts to inhibit the bacterial ribosome. PMID:23979750 TetA(58) is a Tetracycline efflux pump described in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Described by Pawlowski et al. 2016. tetA(58) antibiotic_resistance ARO:3003980 tetA(58) ARO:3003980 TetA(58) is a Tetracycline efflux pump described in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Described by Pawlowski et al. 2016. PMID:27929110 tetA(58) Tetracycline resistant TetB(58) efflux pump found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Described by Pawlowski et al. 2016. tetB(58) antibiotic_resistance ARO:3003981 tetB(58) ARO:3003981 Tetracycline resistant TetB(58) efflux pump found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Described by Pawlowski et al. 2016. PMID:27929110 tetB(58) Lincosamide (Clindamycin) resistant (putative) ribosomal methyltransferase related to the RlmK 23S rRNA methyltransferase COG family. Detected in Paenibacillus sp. LC231, an isolated strain of Paenibacillus found in Lechuguilla Cave, NM, USA. Described by Pawlowski et al. 2016. LlmA_23S_CLI antibiotic_resistance ARO:3003982 LlmA 23S ribosomal RNA methyltransferase ARO:3003982 Lincosamide (Clindamycin) resistant (putative) ribosomal methyltransferase related to the RlmK 23S rRNA methyltransferase COG family. Detected in Paenibacillus sp. LC231, an isolated strain of Paenibacillus found in Lechuguilla Cave, NM, USA. Described by Pawlowski et al. 2016. PMID:27929110 LlmA_23S_CLI Chloramphenicol acetyltransferase conferring resistance to phenicol antibiotics detected in Paenibacillus sp. LC231, an isolated strain of Paenibacillus from Lechuguilla Cave, NM, USA. Described by Pawlowski et al. 2016. CatU antibiotic_resistance ARO:3003983 CatU ARO:3003983 Chloramphenicol acetyltransferase conferring resistance to phenicol antibiotics detected in Paenibacillus sp. LC231, an isolated strain of Paenibacillus from Lechuguilla Cave, NM, USA. Described by Pawlowski et al. 2016. PMID:27929110 CatU Bacitracin amidohydrolase found in Paenibacillus sp. LC231, an isolated strain of Paenibacillus from Lechuguilla Cave, NM, USA. Confers resistance by bacitracin inactivation through amidohydrolysis. Described by Pawlowski et al. 2016. BahA antibiotic_resistance ARO:3003984 BahA ARO:3003984 Bacitracin amidohydrolase found in Paenibacillus sp. LC231, an isolated strain of Paenibacillus from Lechuguilla Cave, NM, USA. Confers resistance by bacitracin inactivation through amidohydrolysis. Described by Pawlowski et al. 2016. PMID:27929110 BahA Hydrolysis of amido side-chain of asparagine-12 forming hydrogen bond with undecaprenyl pyrophosphate in bacitracin leading to antibiotic inactivation. antibiotic_resistance ARO:3003985 amidohydrolysis of bacitracin undecaprenyl pyrophosphate ARO:3003985 Pleuromutilin (Tiamulin) ABC efflux pump found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to pleuromutilin antibiotics. Described by Pawlowski et al. 2016. TaeA antibiotic_resistance ARO:3003986 TaeA ARO:3003986 Pleuromutilin (Tiamulin) ABC efflux pump found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to pleuromutilin antibiotics. Described by Pawlowski et al. 2016. PMID:27929110 TaeA Streptogramin A acetyltransferase found in Paenibacillus sp. LC231, isolated from Lechuguilla Cave, NM, USA. Confers resistance to streptogramin A antibiotics. Described by Pawlowski et al. 2016. VatI antibiotic_resistance ARO:3003987 VatI ARO:3003987 Streptogramin A acetyltransferase found in Paenibacillus sp. LC231, isolated from Lechuguilla Cave, NM, USA. Confers resistance to streptogramin A antibiotics. Described by Pawlowski et al. 2016. PMID:27929110 VatI AAC(2')-IIb is an intrinsic Kasugamycin 2' acetyltransferase protein found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to aminoglycoside antibiotics, including kasugamycin. Described by Pawlowski et al. 2016. AAC(2')-IIb antibiotic_resistance ARO:3003988 AAC(2')-IIb ARO:3003988 AAC(2')-IIb is an intrinsic Kasugamycin 2' acetyltransferase protein found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to aminoglycoside antibiotics, including kasugamycin. Described by Pawlowski et al. 2016. PMID:27929110 AAC(2')-IIb AAC(6')-34 is an aminoglycoside 6'-phosphotransferase found in Paenibacillus sp. LC231, a strain of Paenibacillus from Lechuguilla Cave, NM, USA. Confers resistance to aminoglycoside antibiotics. Described by Pawlowski et al. 2016. AAC(6')-34 antibiotic_resistance ARO:3003989 AAC(6')-34 ARO:3003989 AAC(6')-34 is an aminoglycoside 6'-phosphotransferase found in Paenibacillus sp. LC231, a strain of Paenibacillus from Lechuguilla Cave, NM, USA. Confers resistance to aminoglycoside antibiotics. Described by Pawlowski et al. 2016. PMID:27929110 AAC(6')-34 VgbC is a streptogramin B-type lyase found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to streptogramin B-type antibiotics by linearization of the lactone ring on an ester bond, resulting in antibiotic inactivation. Described by Pawlowski et al. 2016. vgbC antibiotic_resistance ARO:3003990 vgbC ARO:3003990 VgbC is a streptogramin B-type lyase found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to streptogramin B-type antibiotics by linearization of the lactone ring on an ester bond, resulting in antibiotic inactivation. Described by Pawlowski et al. 2016. PMID:27929110 vgbC mphI is a macrolide phosphotransferase protein found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to macrolide antibiotics. Described by Pawlowski et al. 2016. mphI antibiotic_resistance ARO:3003991 mphI ARO:3003991 mphI is a macrolide phosphotransferase protein found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to macrolide antibiotics. Described by Pawlowski et al. 2016. PMID:27929110 PMID:29317655 mphI rphB is a rifampin phosphotransferase protein found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to rifamycin antibiotics, specifically rifampin, through rifampin inactivation. Described by Pawlowski et al. 2016. rphB antibiotic_resistance ARO:3003992 rphB ARO:3003992 rphB is a rifampin phosphotransferase protein found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Confers resistance to rifamycin antibiotics, specifically rifampin, through rifampin inactivation. Described by Pawlowski et al. 2016. PMID:27929110 rphB Capreomycin is an aminoglycoside antibiotic, capable of treating a large number of infections but in particular used for killing bacteria causing tuberculosis. CAS:11003-38-6 ChEBI:3371 ChEMBL:CHEMBL2221250 PubChem:122130878 antibiotic_resistance ARO:3003993 capreomycin ARO:3003993 Capreomycin is an aminoglycoside antibiotic, capable of treating a large number of infections but in particular used for killing bacteria causing tuberculosis. PMID:73540 cpaA is a capreomycin acetyltransferase protein found in Paenibacillus sp. LC231, an isolated strain of Paenibacillus in Lechuguilla Cave, NM, USA. Confers resistance to capreomycin, an aminoglycoside antibiotic. Described by Pawlowski et al. 2016. cpaA antibiotic_resistance ARO:3003994 cpaA ARO:3003994 cpaA is a capreomycin acetyltransferase protein found in Paenibacillus sp. LC231, an isolated strain of Paenibacillus in Lechuguilla Cave, NM, USA. Confers resistance to capreomycin, an aminoglycoside antibiotic. Described by Pawlowski et al. 2016. PMID:27929110 cpaA Amino acid substitutions in Clostridioides difficile gyrase subunit A which when present confer functional resistance to fluoroquinolone antibiotics. Cdif_gyrA_FLO antibiotic_resistance ARO:3003995 Clostridioides difficile gyrA conferring resistance to fluoroquinolones ARO:3003995 Amino acid substitutions in Clostridioides difficile gyrase subunit A which when present confer functional resistance to fluoroquinolone antibiotics. PMID:11451695 PMID:12384345 PMID:12848728 PMID:18480338 PMID:19364867 PMID:19818865 PMID:20226332 PMID:22508299 PMID:27842877 Cdif_gyrA_FLO An antibiotic cocktail containing the beta-lactam antibiotic Amoxicillin and the beta-lactamase inhibitor Clavulanic Acid (potassium clavulanate). ChEBI:201491 ChEMBL:CHEMBL1697738 PubChem:23665637 AMC amoxicillin-clavulanate clavamox co-amoxiclav antibiotic_resistance ARO:3003997 amoxicillin-clavulanic acid ARO:3003997 An antibiotic mixture containing the penicillin-derived beta-lactam antibiotic Ampicillin and the beta-lactamase inhibitor Sulbactam. Also known as Unasyn and/or Ampictam. Ampictam SAM Unasyn antibiotic_resistance ARO:3003998 ampicillin-sulbactam ARO:3003998 Cefamandole is a second-generation cephalosporin-class beta-lactam antibiotic. CAS:34444-01-4 ChEBI:3480 ChEMBL:CHEMBL1146 PubChem:456255 FAM antibiotic_resistance ARO:3003999 cefamandole ARO:3003999 Cefetamet is a third-generation semi-synthetic beta-lactam antibiotic that inactivates inner cell wall PBPs through targeting binding, resulting in cell lysis. ChEBI:135629 ChEMBL:CHEMBL2103764 PubChem:5487888 FET cefetametum antibiotic_resistance ARO:3004000 cefetamet ARO:3004000 Cefetamet is a third-generation semi-synthetic beta-lactam antibiotic that inactivates inner cell wall PBPs through targeting binding, resulting in cell lysis. PMID:2504597 Cefmetazole is a semi-synthetic cephamycin antibiotic with broad spectrum antibiotic activity against both gram-positive and gram-negative bacteria, that disrupt cell wall synthesis through binding to PBPs causing cell lysis. CAS:56796-20-4 ChEBI:3489 ChEMBL:CHEMBL1201195 PubChem:42008 CMZ antibiotic_resistance ARO:3004001 cefmetazole ARO:3004001 Cefonicid is a second-generation cephalosporin-class beta-lactam antibiotic with broad spectrum activity. Particularly used against urinary tract infections and lower respiratory infections. Causes cell lysis by inactivation of PBPs through binding, inhibiting peptidoglycan synthesis. CAS:61270-58-4 ChEBI:3491 ChEMBL:CHEMBL1601 PubChem:43594 CID cefonicide antibiotic_resistance ARO:3004002 cefonicid ARO:3004002 Cefoperazone is a semi-synthetic cephalosporin containing a tetrazolyl moiety that is resistant to beta-lactamases. Particularly used for treatment of Pseudomonas spp. infections. CAS:62893-19-0 ChEBI:3493 ChEMBL:CHEMBL507674 PubChem:44187 CFP cefoperazine antibiotic_resistance ARO:3004003 cefoperazone ARO:3004003 Cefoperazone is a semi-synthetic cephalosporin containing a tetrazolyl moiety that is resistant to beta-lactamases. Particularly used for treatment of Pseudomonas spp. infections. PMID:6221381 Cefotetan is a cephamycin-class beta-lactam antibiotic that is highly resistant to beta-lactamases and effective against a wide range of gram-negative and gram-positive bacteria. CAS:69712-56-7 ChEBI:3499 ChEMBL:CHEMBL474579 PubChem:53025 CTT Cefotetanum antibiotic_resistance ARO:3004004 cefotetan ARO:3004004 Cefprozil is a cephalosporin and beta-lactam antibiotic with bactericidal activity. It selectively binds to PBPs and inhibits peptidoglycan synthesis, a major cell wall component, resulting in cell lysis. CAS:92665-29-7 ChEBI:3506 ChEMBL:CHEMBL3301800 PubChem:5281006 Brisoral CPR Cefzil antibiotic_resistance ARO:3004005 cefprozil ARO:3004005 Cefprozil is a cephalosporin and beta-lactam antibiotic with bactericidal activity. It selectively binds to PBPs and inhibits peptidoglycan synthesis, a major cell wall component, resulting in cell lysis. PMID:12841400 Ceftiofur is a third-generation broad spectrum cephalosporin and beta-lactam antibiotic predominantly used in veterinary medicine. It causes cell lysis by disrupting peptidoglycan cross-linkage and cell wall formation by binding to PBPs. CAS:104010-37-9 ChEBI:31383 ChEMBL:CHEMBL222913 PubChem:6328657 Excenel Naxcel antibiotic_resistance ARO:3004006 ceftiofur ARO:3004006 Ceftiofur is a third-generation broad spectrum cephalosporin and beta-lactam antibiotic predominantly used in veterinary medicine. It causes cell lysis by disrupting peptidoglycan cross-linkage and cell wall formation by binding to PBPs. PMID:3631686 Ceftizoxime is a third-generation cephalosporin and broad spectrum beta-lactam antibiotic. Ceftizoxime causes bacterial cell lysis through peptidoglycan cross-linking inhibition by binding to PBPs. CAS:68401-81-0 ChEBI:553473 ChEMBL:CHEMBL528 PubChem:6533629 ZOX antibiotic_resistance ARO:3004007 ceftizoxime ARO:3004007 Ceftizoxime is a third-generation cephalosporin and broad spectrum beta-lactam antibiotic. Ceftizoxime causes bacterial cell lysis through peptidoglycan cross-linking inhibition by binding to PBPs. PMID:6326062 Cephapirin is a first-generation cephalosporin and broad spectrum beta-lactam antibiotic. Inactivation of penicillin-binding proteins through cephapirin binding disrupts peptidoglycan cross-linking, resulting in cell lysis. CAS:21593-23-7 ChEBI:554446 ChEMBL:CHEMBL1599 PubChem:30699 HAP cefadyl cefapirin antibiotic_resistance ARO:3004008 cephapirin ARO:3004008 Cefradine is a first-generation cephalosporin and broad spectrum beta-lactam antibiotic. Cefradine binding to penicillin-binding proteins disrupts cell wall peptidoglycan cross-linkage, resulting in cell lysis. CAS:38821-53-3 ChEBI:3547 ChEMBL:CHEMBL1604 PubChem:38103 Cephradine RAD antibiotic_resistance ARO:3004009 cefradine ARO:3004009 Cefradine is a first-generation cephalosporin and broad spectrum beta-lactam antibiotic. Cefradine binding to penicillin-binding proteins disrupts cell wall peptidoglycan cross-linkage, resulting in cell lysis. PMID:4572639 Cinoxacin is a fluoroquinolone antibiotic primarily used for the treatment of urinary tract infections in adults. Cinoxacin binds to DNA gyrase, resulting in double-stranded DNA breaks and cell death. CAS:28657-80-9 ChEBI:3716 ChEMBL:CHEMBL1208 PubChem:2762 Azolinic acid CIN antibiotic_resistance ARO:3004010 cinoxacin ARO:3004010 Cinoxacin is a fluoroquinolone antibiotic primarily used for the treatment of urinary tract infections in adults. Cinoxacin binds to DNA gyrase, resulting in double-stranded DNA breaks and cell death. PMID:7017171 Clinafloxacin is a fluoroquinolone antibiotic and gyrase (DNA topoisomerase II) inhibitor. It binds to DNA gyrase and disrupts replication by causing double-stranded DNA breaks, resulting in cell death. ChEMBL:CHEMBL278255 PubChem:60063 CLX antibiotic_resistance ARO:3004011 clinafloxacin ARO:3004011 Clinafloxacin is a fluoroquinolone antibiotic and gyrase (DNA topoisomerase II) inhibitor. It binds to DNA gyrase and disrupts replication by causing double-stranded DNA breaks, resulting in cell death. PMID:3142350 Clofazimine is a fluoroquinolone-class phenazine dye used for the treatment of leprosy. Clofazimine binds to DNA and disrupts bacterial DNA gyrase, thereby causing double-stranded DNA breaks, and subsequent cell death. CAS:2030-63-9 ChEBI:3749 ChEMBL:CHEMBL1292 PubChem:2794 Lampren Lamprene antibiotic_resistance ARO:3004012 clofazimine ARO:3004012 Clofazimine is a fluoroquinolone-class phenazine dye used for the treatment of leprosy. Clofazimine binds to DNA and disrupts bacterial DNA gyrase, thereby causing double-stranded DNA breaks, and subsequent cell death. PMID:7829710 Fleroxacin is a broad spectrum fluoroquinolone antibiotic that inhibits the DNA supercoiling activity of bacterial DNA gyrase, resulting in double-stranded DNA breaks and subsequent cell death. CAS:79660-72-3 ChEBI:31810 ChEMBL:CHEMBL6273 PubChem:3357 Megalocin Quinodis antibiotic_resistance ARO:3004013 fleroxacin ARO:3004013 Fleroxacin is a broad spectrum fluoroquinolone antibiotic that inhibits the DNA supercoiling activity of bacterial DNA gyrase, resulting in double-stranded DNA breaks and subsequent cell death. PMID:2112571 Flomoxef is an oxacephem antibiotic which was effective in preventing the growth of all ESBL-producing strains and is widely active against Gram-positive, Gram-negative, and anaerobic bacteria. It is sometimes classified as a second-generation or fourth-generation cephalosporin. CAS:99665-00-6 ChEBI:135813 ChEMBL:CHEMBL15413 PubChem:65864 antibiotic_resistance ARO:3004014 flomoxef ARO:3004014 Flomoxef is an oxacephem antibiotic which was effective in preventing the growth of all ESBL-producing strains and is widely active against Gram-positive, Gram-negative, and anaerobic bacteria. It is sometimes classified as a second-generation or fourth-generation cephalosporin. PMID:37610203 PMID:4008339 Gentamicin A is part of a complex of broad spectrum aminoglycoside antibiotics. Gentamicin inhibits protein synthesis, resulting in bacterial cell death. CAS:13291-74-2 ChEBI:28418 ChEMBL:CHEMBL7225 PubChem:12810388 Garamycin antibiotic_resistance ARO:3004015 gentamicin A ARO:3004015 Gentamicin A is part of a complex of broad spectrum aminoglycoside antibiotics. Gentamicin inhibits protein synthesis, resulting in bacterial cell death. PMID:10103173 PMID:11083623 Loracarbef is a second-generation cephalosporin (carbacephem) and broad spectrum beta-lactam antibiotic. Loracarbef inhibits PBPs through binding, disrupting peptidoglycan cell wall cross-linkage and resulting in cell death. CAS:76470-66-1 ChEBI:47544 ChEMBL:CHEMBL1200610 PubChem:5284585 Lorabid Loracarbefum antibiotic_resistance ARO:3004016 loracarbef ARO:3004016 Loracarbef is a second-generation cephalosporin (carbacephem) and broad spectrum beta-lactam antibiotic. Loracarbef inhibits PBPs through binding, disrupting peptidoglycan cell wall cross-linkage and resulting in cell death. PMID:3501757 PMID:8453172 Moxalactam (Latamoxef) is a broad spectrum cephalosporin (oxacephem) and beta-lactam antibiotic. Moxalactam binding to PBPs inhibits peptidoglycan cross-linkage in the cell wall, resulting in cell death. Moxalactam is proposed to be effective against meningitides as it passes the blood-brain barrier. CAS:64952-97-2 ChEBI:599928 ChEMBL:CHEMBL74632 PubChem:47499 Latamoxef antibiotic_resistance ARO:3004017 moxalactam ARO:3004017 Moxalactam (Latamoxef) is a broad spectrum cephalosporin (oxacephem) and beta-lactam antibiotic. Moxalactam binding to PBPs inhibits peptidoglycan cross-linkage in the cell wall, resulting in cell death. Moxalactam is proposed to be effective against meningitides as it passes the blood-brain barrier. PMID:315938 PMID:6218558 Nafcillin is a penicillin-class narrow-spectrum beta-lactam antibiotic. It inhibits cell wall synthesis and peptidoglycan cross-linkage through binding to PBPs, similarly to other penicillin-like antibiotics. CAS:147-52-4 ChEBI:7447 ChEMBL:CHEMBL1443 PubChem:8982 Nafcil antibiotic_resistance ARO:3004018 nafcillin ARO:3004018 Para-aminosalicylic acid (PAS) is an anti-tubercular antibiotic agent, often used in conjunction with Isoniazid for treatment of M. tuberculosis infections. PAS diminishes bacterial cell growth by limiting folic acid production. CAS:65-49-6 ChEBI:27565 ChEMBL:CHEMBL1169 PubChem:4649 4-aminosalicylic acid antibiotic_resistance ARO:3004019 para-aminosalicylic acid ARO:3004019 An antibiotic cocktail containing the beta-lactam penam antibiotic Piperacillin and the beta-lactamase inhibitor sulbactam. antibiotic_resistance ARO:3004020 piperacillin-sulbactam ARO:3004020 An antibiotic cocktail containing the penam beta-lactam antibiotic Piperacillin and the beta-lactamase inhibitor Tazobactam. PubChem:23724843 Tazocin Zosyn antibiotic_resistance ARO:3004021 piperacillin-tazobactam ARO:3004021 An antibiotic cocktail of the streptogramin A dalfopristin and the streptogramin B quinupristin antibiotics. Used particularly to treat MRSA and vancomycin-resistant Enterococcus. ChEBI:8733 ChEMBL:CHEMBL3137691 PubChem:25199981 Synercid antibiotic_resistance ARO:3004022 quinupristin-dalfopristin ARO:3004022 An antibiotic cocktail containing the beta-lactam antibiotic ticarcillin and the beta-lactamase inhibitor clavulanic acid (clavulanate). PubChem:6437075 co-ticarclav antibiotic_resistance ARO:3004023 ticarcillin-clavulanic acid ARO:3004023 An antibiotic cocktail containing the diaminopyrimidine antibiotic Trimethoprim and the sulfonamide antibiotic sulfamethoxazole (1 TMP:5 SMX). CAS:8064-90-2 ChEBI:3770 PubChem:358641 cotrimoxazole antibiotic_resistance ARO:3004024 trimethoprim-sulfamethoxazole ARO:3004024 Prothionamide is a thioamide derivative with antibacterial properties. It increases cell wall permeability and decreases cell wall damage resistance by inhibition of mycolic acid synthesis, resulting in cell death. It is particularly used to treat M. tuberculosis and M. leprae infections. CAS:14222-60-7 ChEBI:32066 ChEMBL:CHEMBL1378024 PubChem:666418 protionamide antibiotic_resistance ARO:3004025 prothionamide ARO:3004025 Prothionamide is a thioamide derivative with antibacterial properties. It increases cell wall permeability and decreases cell wall damage resistance by inhibition of mycolic acid synthesis, resulting in cell death. It is particularly used to treat M. tuberculosis and M. leprae infections. PMID:6459296 Tinidazole is a nitroimidazole anti-parasitic drug. It is used in the treatment of protozoan infections. ChEBI:63627 ChEMBL:CHEMBL1220 PubChem:5479 Fasigyn Simplotan Sporinex Tindamax antibiotic_resistance ARO:3004026 tinidazole ARO:3004026 Tinidazole is a nitroimidazole anti-parasitic drug. It is used in the treatment of protozoan infections. PMID:3733593 An efflux pump/potassium antiporter system (RosAB) formed by the RosA and RosB proteins found in Yersinia. antibiotic_resistance ARO:3004030 RosAB ARO:3004030 An efflux pump/potassium antiporter system (RosAB) formed by the RosA and RosB proteins found in Yersinia. PMID:10931306 PMID:12010497 tetAB(46) is a heterodimeric ABC transporter conferring tetracycline resistance in Streptococcus australis isolated from the oral cavity. Both tetA(46) and tetB(46) genes are required for resistance. antibiotic_resistance ARO:3004031 tetAB(46) ARO:3004031 tetAB(46) is a heterodimeric ABC transporter conferring tetracycline resistance in Streptococcus australis isolated from the oral cavity. Both tetA(46) and tetB(46) genes are required for resistance. PMID:22941900 tetA(46) is a subunit of tetAB(46), a heterodimeric ABC transporter, that is required for conferring tetracycline resistance in Streptococcus australis isolated from the oral cavity. tetA(46) antibiotic_resistance ARO:3004032 tetA(46) ARO:3004032 tetA(46) is a subunit of tetAB(46), a heterodimeric ABC transporter, that is required for conferring tetracycline resistance in Streptococcus australis isolated from the oral cavity. PMID:22941900 tetA(46) tetB(46) is a subunit of tetAB(46), a heterodimeric ABC transporter, that is required for conferring tetracycline resistance in Streptococcus australis isolated from the oral cavity. tetB(46) antibiotic_resistance ARO:3004033 tetB(46) ARO:3004033 tetB(46) is a subunit of tetAB(46), a heterodimeric ABC transporter, that is required for conferring tetracycline resistance in Streptococcus australis isolated from the oral cavity. PMID:22941900 tetB(46) tetAB(60) is an ABC transporter that confers resistance to tetracycline and tigercycline identified by screening a human saliva metagenomic library in Escherichia coli. Both tetA(60) and tetB(60) are required for resistance. antibiotic_resistance ARO:3004034 tetAB(60) ARO:3004034 tetAB(60) is an ABC transporter that confers resistance to tetracycline and tigercycline identified by screening a human saliva metagenomic library in Escherichia coli. Both tetA(60) and tetB(60) are required for resistance. PMID:27999567 tetA(60) is a subunit of tetAB(60), an ABC transporter that confers resistance to tetracycline and tigercycline identified by screening a human saliva metagenomic library in Escherichia coli, which is required for resistance. tetA(60) antibiotic_resistance ARO:3004035 tetA(60) ARO:3004035 tetA(60) is a subunit of tetAB(60), an ABC transporter that confers resistance to tetracycline and tigercycline identified by screening a human saliva metagenomic library in Escherichia coli, which is required for resistance. PMID:27999567 tetA(60) tetB(60) is a subunit of tetAB(60), an ABC transporter that confers resistance to tetracycline and tigercycline identified by screening a human saliva metagenomic library in Escherichia coli, which is required for resistance. tetB(60) antibiotic_resistance ARO:3004036 tetB(60) ARO:3004036 tetB(60) is a subunit of tetAB(60), an ABC transporter that confers resistance to tetracycline and tigercycline identified by screening a human saliva metagenomic library in Escherichia coli, which is required for resistance. PMID:27999567 tetB(60) EmrE is a small multidrug transporter that functions as a homodimer and that couples the efflux of small polyaromatic cations from the cell with the import of protons down an electrochemical gradient. Confers resistance to tetraphenylphosphonium, methyl viologen, gentamicin, kanamycin, and neomycin. PDB:3B61 PAsmr Pae-Emre Paer_emrE antibiotic_resistance ARO:3004038 Pseudomonas aeruginosa emrE ARO:3004038 EmrE is a small multidrug transporter that functions as a homodimer and that couples the efflux of small polyaromatic cations from the cell with the import of protons down an electrochemical gradient. Confers resistance to tetraphenylphosphonium, methyl viologen, gentamicin, kanamycin, and neomycin. PMID:12499164 Paer_emrE Member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation. PDB:3B61 Ecol_emrE antibiotic_resistance ARO:3004039 Escherichia coli emrE ARO:3004039 Member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation. PMID:1936950 Ecol_emrE Enzymes, protein or other gene products that inactivate rifampin (rifamycin) antibiotics through phosphorylation of the antibiotic at the 21-OH position. rph antibiotic_resistance ARO:3004040 rifampin phosphotransferase ARO:3004040 AcrA is a subunit of the AcrAB multidrug efflux system that is found in K. pneumoniae, which is encoded by the acrRAB operon. PDB:2F1M Kpne_acrA antibiotic_resistance ARO:3004041 Klebsiella pneumoniae acrA ARO:3004041 AcrA is a subunit of the AcrAB multidrug efflux system that is found in K. pneumoniae, which is encoded by the acrRAB operon. PMID:19858254 PMID:24327941 Kpne_acrA AcrA is a subunit of the AcrAB-TolC multidrug efflux system in E. cloacae. PDB:2F1M Eclo_acrA antibiotic_resistance ARO:3004042 Enterobacter cloacae acrA ARO:3004042 AcrA is a subunit of the AcrAB-TolC multidrug efflux system in E. cloacae. PMID:12121946 PMID:17536927 Eclo_acrA AcrA is a subunit of the AcrAB-TolC multidrug efflux system found in E. coli. PDB:2F1M Ecol_acrA antibiotic_resistance ARO:3004043 Escherichia coli acrA ARO:3004043 AcrA is a subunit of the AcrAB-TolC multidrug efflux system found in E. coli. PMID:11321576 PMID:12363006 PMID:24747401 Ecol_acrA fabI is a bacterial enoyl-acyl carrier reductase (ENR) isozyme. As with other ENRs, mutations in fabI can confer resistance to the biocide triclosan. antibiotic_resistance ARO:3004044 antibiotic sensitive fabI ARO:3004044 fabI is a enoyl-acyl carrier reductase used in lipid metabolism and fatty acid biosynthesis. The bacterial biocide Triclosan blocks the final reduction step in fatty acid elongation, inhibiting biosynthesis. Point mutations in fabI can confer resistance to Triclosan and Isoniazid. Ecol_fabI_MULT antibiotic_resistance ARO:3004045 Escherichia coli fabI mutations conferring resistance to isoniazid and triclosan ARO:3004045 fabI is a enoyl-acyl carrier reductase used in lipid metabolism and fatty acid biosynthesis. The bacterial biocide Triclosan blocks the final reduction step in fatty acid elongation, inhibiting biosynthesis. Point mutations in fabI can confer resistance to Triclosan and Isoniazid. PMID:27577999 Ecol_fabI_MULT kdpDE is a two-component regulatory system in Escherichia coli, well studied for its role in potassium transport and homeostasis. kdpE is also implicated in virulence loci regulation and overexpression of kdpE is shown to confer resistance to aminoglycoside antibiotics. antibiotic_resistance ARO:3004046 kdpDE ARO:3004046 kdpDE is a two-component regulatory system in Escherichia coli, well studied for its role in potassium transport and homeostasis. kdpE is also implicated in virulence loci regulation and overexpression of kdpE is shown to confer resistance to aminoglycoside antibiotics. PMID:23555240 kdpD is a component of the two-component regulatory system, kdpDE. This system is involved in potassium transport and homeostasis, and has been implicated in virulence factor regulation along with kdpE. kdpD antibiotic_resistance ARO:3004047 kdpD ARO:3004047 kdpD is a component of the two-component regulatory system, kdpDE. This system is involved in potassium transport and homeostasis, and has been implicated in virulence factor regulation along with kdpE. PMID:23555240 kdpD fabG is a 3-oxoacyl-acyl carrier protein reductase involved in lipid metabolism and fatty acid biosynthesis.The bacterial biocide Triclosan blocks the final reduction step in fatty acid elongation, inhibiting biosynthesis. Point mutations in fabG can confer resistance to Triclosan. Ecol_fabG_TRC antibiotic_resistance ARO:3004049 Escherichia coli fabG mutations conferring resistance to triclosan ARO:3004049 fabG is a 3-oxoacyl-acyl carrier protein reductase involved in lipid metabolism and fatty acid biosynthesis.The bacterial biocide Triclosan blocks the final reduction step in fatty acid elongation, inhibiting biosynthesis. Point mutations in fabG can confer resistance to Triclosan. PMID:27577999 Ecol_fabG_TRC fabG is a bacterial 3-oxoacyl enoyl-acyl carrier reductase (ENR) isozyme. As with other ENRs, mutations in fabG are shown to confer resistance to the biocide triclosan. antibiotic_resistance ARO:3004050 antibiotic sensitive fabG ARO:3004050 fabG is a bacterial 3-oxoacyl enoyl-acyl carrier reductase (ENR) isozyme. As with other ENRs, mutations in fabG are shown to confer resistance to the biocide triclosan. PMID:27577999 CpxR is directly involved in activation of expression of RND efflux pump MexAB-OprM in P. aeruginosa. CpxR is required to enhance mexAB-oprM expression and drug resistance, in the absence of repressor MexR. Paer_CpxR antibiotic_resistance ARO:3004054 Pseudomonas aeruginosa CpxR ARO:3004054 CpxR is directly involved in activation of expression of RND efflux pump MexAB-OprM in P. aeruginosa. CpxR is required to enhance mexAB-oprM expression and drug resistance, in the absence of repressor MexR. PMID:27736975 Paer_CpxR The Escherichia coli CpxR/CpxA system responds to general periplasmic stress and has been used as a model two-component system for transcription regulation in bacteria. CpxR/CpxA system facilitates Salmonella and E. coli resistance to cationic antimicrobial peptides.The CpxR/CpxA system can activate transcription of marRAB operon, thus facilitating multidrug-resistant regulator to enhance expression of TolC-dependent tripartite multidrug transporters. Ecol_CpxR antibiotic_resistance ARO:3004055 Escherichia coli CpxR ARO:3004055 The Escherichia coli CpxR/CpxA system responds to general periplasmic stress and has been used as a model two-component system for transcription regulation in bacteria. CpxR/CpxA system facilitates Salmonella and E. coli resistance to cationic antimicrobial peptides.The CpxR/CpxA system can activate transcription of marRAB operon, thus facilitating multidrug-resistant regulator to enhance expression of TolC-dependent tripartite multidrug transporters. PMID:25294881 Ecol_CpxR ArmR, a 53-amino-acid antirepressor, allosterically inhibits MexR dimer-DNA binding by occupying a hydrophobic binding cavity within the center of the MexR dimer. ArmR up-regulation and MexR-ArmR complex formation have previously been shown to upregulate MexAB-OprM. ArmR antibiotic_resistance ARO:3004056 ArmR ARO:3004056 ArmR, a 53-amino-acid antirepressor, allosterically inhibits MexR dimer-DNA binding by occupying a hydrophobic binding cavity within the center of the MexR dimer. ArmR up-regulation and MexR-ArmR complex formation have previously been shown to upregulate MexAB-OprM. PMID:17545281 PMID:18812515 ArmR Point mutations in the 23S rRNA subunit may confer resistance to linezolid and other oxazolidinone antibiotics. antibiotic_resistance ARO:3004057 23S rRNA with mutation conferring resistance to linezolid antibiotics ARO:3004057 Point mutations in the 23S rRNA subunit may confer resistance to linezolid and other oxazolidinone antibiotics. PMID:27727405 Point mutations in the 23S rRNA subunit of the large ribosomal bacterial subunit in Staphylococcus aureus, which confer resistance to linezolid by disrupting antibiotic target binding. Saur_23S_LZD antibiotic_resistance ARO:3004058 Staphylococcus aureus 23S rRNA with mutation conferring resistance to linezolid ARO:3004058 Point mutations in the 23S rRNA subunit of the large ribosomal bacterial subunit in Staphylococcus aureus, which confer resistance to linezolid by disrupting antibiotic target binding. PMID:27727405 Saur_23S_LZD Type A NfxB mutants are four to eight times more resistant to ofloxacin, erythromycin, and new zwitterionic cephems, i.e., cefpirome, cefclidin, cefozopran, and cefoselis, than the parent strain, PAO1. nfxB corresponds to 2 loci in Pseudomonas aeruginosa PAO1 (gene name: esrC/nfxB) and 2 loci in Pseudomonas aeruginosa LESB58 (gene name: nfxB). Type_A_NfxB esrC antibiotic_resistance ARO:3004059 Type A NfxB ARO:3004059 Type A NfxB mutants are four to eight times more resistant to ofloxacin, erythromycin, and new zwitterionic cephems, i.e., cefpirome, cefclidin, cefozopran, and cefoselis, than the parent strain, PAO1. nfxB corresponds to 2 loci in Pseudomonas aeruginosa PAO1 (gene name: esrC/nfxB) and 2 loci in Pseudomonas aeruginosa LESB58 (gene name: nfxB). PMID:1330820 PMID:8849250 PMID:8878035 Type_A_NfxB Type B NfxB mutants are more resistant to tetracycline and chloramphenicol, as well as ofloxacin, erythromycin, and the new zwitterionic cephems, than was PAO1, and they are four to eight times more susceptible to carbenicillin, sulbenicillin, imipenem, panipenem, biapenem, moxalactam, aztreonam, gentamicin, and kanamycin than PAO1. The mutation at the 46th amino acid position is sufficient for overproduction of OprJ and the multidrug resistance. nfxB corresponds to 2 loci in Pseudomonas aeruginosa PAO1 (gene name: esrC/nfxB) and 2 loci in Pseudomonas aeruginosa LESB58 (gene name: nfxB). Type_B_NfxB esrC antibiotic_resistance ARO:3004060 Type B NfxB ARO:3004060 Type B NfxB mutants are more resistant to tetracycline and chloramphenicol, as well as ofloxacin, erythromycin, and the new zwitterionic cephems, than was PAO1, and they are four to eight times more susceptible to carbenicillin, sulbenicillin, imipenem, panipenem, biapenem, moxalactam, aztreonam, gentamicin, and kanamycin than PAO1. The mutation at the 46th amino acid position is sufficient for overproduction of OprJ and the multidrug resistance. nfxB corresponds to 2 loci in Pseudomonas aeruginosa PAO1 (gene name: esrC/nfxB) and 2 loci in Pseudomonas aeruginosa LESB58 (gene name: nfxB). PMID:8849250 PMID:8878035 PMID:9449262 Type_B_NfxB MexCD–OprJ with type A NfxB phenotype are four to eight times more resistant to ofloxacin, erythromycin, and new zwitterionic cephems, i.e., cefpirome, cefclidin, cefozopran, and cefoselis, than the parent strain, PAO1. Paer_NfxBa_MULT antibiotic_resistance ARO:3004061 MexCD-OprJ with type A NfxB mutation ARO:3004061 MexCD–OprJ with type A NfxB phenotype are four to eight times more resistant to ofloxacin, erythromycin, and new zwitterionic cephems, i.e., cefpirome, cefclidin, cefozopran, and cefoselis, than the parent strain, PAO1. PMID:8849250 Paer_NfxBa_MULT MexCD-OprJ with Type B NfxB mutions are more resistant to tetracycline and chloramphenicol, as well as ofloxacin, erythromycin, and the new zwitterionic cephems, than was PAO1, and they are four to eight times more susceptible to carbenicillin, sulbenicillin, imipenem, panipenem, biapenem, moxalactam, aztreonam, gentamicin, and kanamycin than PAO1. Paer_NfxBb_MULT antibiotic_resistance ARO:3004062 MexCD-OprJ with type B NfxB mutation ARO:3004062 MexCD-OprJ with Type B NfxB mutions are more resistant to tetracycline and chloramphenicol, as well as ofloxacin, erythromycin, and the new zwitterionic cephems, than was PAO1, and they are four to eight times more susceptible to carbenicillin, sulbenicillin, imipenem, panipenem, biapenem, moxalactam, aztreonam, gentamicin, and kanamycin than PAO1. PMID:8849250 Paer_NfxBb_MULT EdeQ is an N-acetyltransferase enzyme that confers high-level self-resistance to edeine in Brevibacillus brevis, a natural edeine producer. EdeQ converts active edeine to N-acetyledeine, which is ineffective in vivo. EdeQ antibiotic_resistance ARO:3004063 EdeQ ARO:3004063 EdeQ is an N-acetyltransferase enzyme that confers high-level self-resistance to edeine in Brevibacillus brevis, a natural edeine producer. EdeQ converts active edeine to N-acetyledeine, which is ineffective in vivo. PMID:23891151 EdeQ Edeine acetyltransferase enzymes catalyze the transfer of an acetyl group to active edeine, converting it to an inactive form in vivo. This mechanism is used for high-level self-resistance in edeine-producing Brevibacillus spp. antibiotic_resistance ARO:3004064 Edeine acetyltransferase ARO:3004064 Edeine acetyltransferase enzymes catalyze the transfer of an acetyl group to active edeine, converting it to an inactive form in vivo. This mechanism is used for high-level self-resistance in edeine-producing Brevibacillus spp. PMID:23891151 The MexEF–OprN efflux pump in P. aeruginosa is overexpressed with MexT mutation conferring resistance to chloramphenicol and ciprofloxacin. Paer_MexT_MULT antibiotic_resistance ARO:3004066 MexEF-OprN with MexT mutation conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim ARO:3004066 The MexEF–OprN efflux pump in P. aeruginosa is overexpressed with MexT mutation conferring resistance to chloramphenicol and ciprofloxacin. PMID:26833155 Paer_MexT_MULT Subclass B1 (metallo-) beta-lactamases found in Myroides spp., which confer resistance to carbapenam class beta-lactamase antibiotics. antibiotic_resistance ARO:3004067 MUS beta-lactamase ARO:3004067 The MexEF–OprN efflux pump with MexS mutations conferring resistance to chloramphenicol and ciprofloxacin. The model includes the MexT regulator, as MexS is suggested to inactivate MexT. Paer_MexS_MULT antibiotic_resistance ARO:3004068 MexEF-OprN with MexS mutations conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim ARO:3004068 The MexEF–OprN efflux pump with MexS mutations conferring resistance to chloramphenicol and ciprofloxacin. The model includes the MexT regulator, as MexS is suggested to inactivate MexT. PMID:26833155 Paer_MexS_MULT MvaT, a global regulator of virulence genes in P. aeruginosa, has also shown to be able to repress the expression of the MexEF-OprN pump. MvaT antibiotic_resistance ARO:3004069 MvaT ARO:3004069 MvaT, a global regulator of virulence genes in P. aeruginosa, has also shown to be able to repress the expression of the MexEF-OprN pump. PMID:16448502 MvaT A deletion of MvaT results in the overexpression of MexEF-OprN conferring resistance to chloramphenicol and norfloxacin. Paer_MvaT_MULT antibiotic_resistance ARO:3004070 MexEF-OprN with MvaT deletion conferring resistance to chloramphenicol and norfloxacin ARO:3004070 A deletion of MvaT results in the overexpression of MexEF-OprN conferring resistance to chloramphenicol and norfloxacin. PMID:16448502 PMID:21911574 Paer_MvaT_MULT OpmB is an outer membrane efflux protein in Pseudomonas aeruginosa that shows functional cooperation with MuxABC, to form the efflux pump system MuxABC-OpmB. OpmB PA2525 antibiotic_resistance ARO:3004072 OpmB ARO:3004072 OpmB is an outer membrane efflux protein in Pseudomonas aeruginosa that shows functional cooperation with MuxABC, to form the efflux pump system MuxABC-OpmB. PMID:12445646 OpmB MuxA is a membrane fusion protein component of the efflux pump system MuxABC-OpmB in Pseudomonas aeruginosa. MuxA PA2528 antibiotic_resistance ARO:3004073 MuxA ARO:3004073 MuxA is a membrane fusion protein component of the efflux pump system MuxABC-OpmB in Pseudomonas aeruginosa. PMID:19713238 MuxA MuxB is one of the two necessary RND components in the Pseudomonas aeruginosa efflux pump system MuxABC-OpmB. MuxB PA2527 antibiotic_resistance ARO:3004074 MuxB ARO:3004074 MuxB is one of the two necessary RND components in the Pseudomonas aeruginosa efflux pump system MuxABC-OpmB. PMID:19713238 MuxB MuxC is one of the two necessary RND components of the MuxABC-OpmB efflux pumps system in Pseudomonas aeruginosa. MuxC PA2526 antibiotic_resistance ARO:3004075 MuxC ARO:3004075 MuxC is one of the two necessary RND components of the MuxABC-OpmB efflux pumps system in Pseudomonas aeruginosa. PMID:19713238 MuxC MuxABC-OpmB is an RND-type multidrug efflux pump in Pseudomonas aeruginosa. This efflux pump confers resistance to aztreonam, novobiocin, tetracycline, erythromycin, kitasamycin and rokitamycin. MuxABC-OpmB antibiotic_resistance ARO:3004076 MuxABC-OpmB ARO:3004076 MuxABC-OpmB is an RND-type multidrug efflux pump in Pseudomonas aeruginosa. This efflux pump confers resistance to aztreonam, novobiocin, tetracycline, erythromycin, kitasamycin and rokitamycin. PMID:19713238 MuxABC-OpmB PmpM is a multidrug efflux pump belonging to the MATE family of Pseudomonas aeruginosa. PmpM is an H+ drug antiporter and is the first reported case of an H+ coupled efflux pump in the MATE family. PmpM confers resistance to fluoroquinolones, fradiomycin, benzalkonium chloride, chlorhexidine gluconate, ethidium bromide, tetraphenylphosphonium chloride (TPPCl), and rhodamine 6G. PA1361 PmpM antibiotic_resistance ARO:3004077 PmpM ARO:3004077 PmpM is a multidrug efflux pump belonging to the MATE family of Pseudomonas aeruginosa. PmpM is an H+ drug antiporter and is the first reported case of an H+ coupled efflux pump in the MATE family. PmpM confers resistance to fluoroquinolones, fradiomycin, benzalkonium chloride, chlorhexidine gluconate, ethidium bromide, tetraphenylphosphonium chloride (TPPCl), and rhodamine 6G. PMID:14679249 PmpM AcrAD-TolC efflux pump system in E. coli from the resistance-nodulation-division family, was shown to participate in the efflux of aminoglycosides. AcrAD-TolC antibiotic_resistance ARO:3004082 AcrAD-TolC ARO:3004082 AcrAD-TolC efflux pump system in E. coli from the resistance-nodulation-division family, was shown to participate in the efflux of aminoglycosides. PMID:10692383 PMID:14706082 AcrAD-TolC AcrEF-TolC efflux pump system of E. coli confers resistance to fluoroquinolones (ciprofloxacin). AcrEF_TolC_CIP antibiotic_resistance ARO:3004083 AcrEF-TolC confers resistance to ciprofloxacin ARO:3004083 AcrEF-TolC efflux pump system of E. coli confers resistance to fluoroquinolones (ciprofloxacin). PMID:10952561 PMID:16267305 AcrEF_TolC_CIP lnuG is a transposon-mediated lincosamide nucleotidyltransferase found in Enterococcus faecalis on Tn6260. lnuG antibiotic_resistance ARO:3004085 lnuG ARO:3004085 lnuG is a transposon-mediated lincosamide nucleotidyltransferase found in Enterococcus faecalis on Tn6260. PMID:28039271 lnuG APH(3')-VIIIb is an aminoglycoside phosphoryltransferase that acts on the 3-OH target of aminoglycosides found in Acinetobacter rudis. APH(3')-VIIIb antibiotic_resistance ARO:3004086 APH(3')-VIIIb ARO:3004086 APH(3')-VIIIb is an aminoglycoside phosphoryltransferase that acts on the 3-OH target of aminoglycosides found in Acinetobacter rudis. PMID:27965516 APH(3')-VIIIb APH(3')-IXa is an aminoglycoside phosphoryltransferase that acts on the 3-OH target of aminoglycosides. APH(3')-IXa antibiotic_resistance ARO:3004087 APH(3')-IXa ARO:3004087 APH(3')-IXa is an aminoglycoside phosphoryltransferase that acts on the 3-OH target of aminoglycosides. PMID:27965516 APH(3')-IXa Lefamulin is a semi-synthetic pleuromutilin compound highly active against multi-resistant pathogens. ChEMBL:CHEMBL3291398 PubChem:25185057 antibiotic_resistance ARO:3004088 lefamulin ARO:3004088 Lefamulin is a semi-synthetic pleuromutilin compound highly active against multi-resistant pathogens. PMID:27958389 PMID:32493034 ANT(3'')-IIa is a aminoglycoside nucleotidyltransferase identified in Acinetobacter spp. via horizontal gene transfer mechanisms. ANT(3'')-IIa ANT(9)(3'') aadA1-pm antibiotic_resistance ARO:3004089 ANT(3'')-IIa ARO:3004089 ANT(3'')-IIa is a aminoglycoside nucleotidyltransferase identified in Acinetobacter spp. via horizontal gene transfer mechanisms. PMID:28152054 ANT(3'')-IIa ANT(3'')-IIb is a aminoglycoside nucleotidyltransferase identified in Acinetobacter spp. via horizontal gene transfer mechanisms. ANT(3'')-IIb antibiotic_resistance ARO:3004090 ANT(3'')-IIb ARO:3004090 ANT(3'')-IIb is a aminoglycoside nucleotidyltransferase identified in Acinetobacter spp. via horizontal gene transfer mechanisms. PMID:28152054 ANT(3'')-IIb ANT(3'')-IIc is a aminoglycoside nucleotidyltransferase identified in Acinetobacter spp. via horizontal gene transfer mechanisms. ANT(3'')-IIc antibiotic_resistance ARO:3004091 ANT(3'')-IIc ARO:3004091 ANT(3'')-IIc is a aminoglycoside nucleotidyltransferase identified in Acinetobacter spp. via horizontal gene transfer mechanisms. PMID:28152054 ANT(3'')-IIc Shotgun cloning of beta-lactam resistant P. aeruginosa NRZ-03096 yielded a clone producing a novel subclass B1 enzyme with only 74.3% identity to the next nearest relative, KHM-1. The novel MBL was named HMB-1 (for Hamburg MBL). HMB-1 gene was chromosomally located as part of a Tn 3 family transposon that was named Tn 6345, where expression of bla HMB-1 in E. coli TOP10 led to increased resistance to beta-lactams. HMB-1 antibiotic_resistance ARO:3004092 HMB-1 ARO:3004092 Shotgun cloning of beta-lactam resistant P. aeruginosa NRZ-03096 yielded a clone producing a novel subclass B1 enzyme with only 74.3% identity to the next nearest relative, KHM-1. The novel MBL was named HMB-1 (for Hamburg MBL). HMB-1 gene was chromosomally located as part of a Tn 3 family transposon that was named Tn 6345, where expression of bla HMB-1 in E. coli TOP10 led to increased resistance to beta-lactams. PMID:28065891 HMB-1 NDM-17 is a metallo-beta-lactamase isolated from Escherichia coli with enhanced carbapenemase activity compared to NDM-1. NDM-17 antibiotic_resistance ARO:3004093 NDM-17 ARO:3004093 NDM-17 is a metallo-beta-lactamase isolated from Escherichia coli with enhanced carbapenemase activity compared to NDM-1. PMID:28242668 NDM-17 Erm(48) is a macrolide-lincosamide-streptogramin resistance gene identified on resistance plasmid pJW2311. Erm(48) antibiotic_resistance ARO:3004094 Erm(48) ARO:3004094 Erm(48) is a macrolide-lincosamide-streptogramin resistance gene identified on resistance plasmid pJW2311. PMID:28438941 Erm(48) Mutations to the CdsA phosphatidate cytidylyltransferase conferring resistance to daptomycin. antibiotic_resistance ARO:3004096 daptomycin resistant CdsA ARO:3004096 Mutations to the CdsA phosphatidate cytidylyltransferase conferring resistance to daptomycin. PMID:28115347 CdsA is a phosphatidate cytidylyltransferase which plays a role in the production of membrane phosphatidylglycerol and cardiolipin. Smit_CdsA_DAP antibiotic_resistance ARO:3004097 Streptococcus mitis CdsA with mutation conferring daptomycin resistance ARO:3004097 CdsA is a phosphatidate cytidylyltransferase which plays a role in the production of membrane phosphatidylglycerol and cardiolipin. PMID:28115347 Smit_CdsA_DAP LpeAB are components of an efflux pump, which is a macrolide resistance determinant in L. pneumophila Paris strain. Mutations observed in the upstream sequence of lpeAB operon in resistant lineages led to an overexpression of this efflux pump. Sub-inhibitory concentrations of macrolides themselves participated in upregulating this efflux and could constitute a first step in the acquisition of a high macrolide resistance level. As Lpp2879–Lpp2880 is homologous to Escherichia coli AcrAB, lpp2879–lpp2880 was renamed to lpeAB. lpp2879-lpp2880 antibiotic_resistance ARO:3004098 LpeAB ARO:3004098 LpeAB are components of an efflux pump, which is a macrolide resistance determinant in L. pneumophila Paris strain. Mutations observed in the upstream sequence of lpeAB operon in resistant lineages led to an overexpression of this efflux pump. Sub-inhibitory concentrations of macrolides themselves participated in upregulating this efflux and could constitute a first step in the acquisition of a high macrolide resistance level. As Lpp2879–Lpp2880 is homologous to Escherichia coli AcrAB, lpp2879–lpp2880 was renamed to lpeAB. PMID:28137939 LpeA is a subunit of the LpeAB efflux pump in Legionella pneumophila, which is homologous to AcrA in E. coli. LpeA lpp2879 antibiotic_resistance ARO:3004099 LpeA ARO:3004099 LpeA is a subunit of the LpeAB efflux pump in Legionella pneumophila, which is homologous to AcrA in E. coli. PMID:28137939 LpeA LpeB is a subunit of the LpeAB efflux pump in Legionella pneumophila, which is homologous to AcrB in E. coli. LpeB lpp2880 antibiotic_resistance ARO:3004100 LpeB ARO:3004100 LpeB is a subunit of the LpeAB efflux pump in Legionella pneumophila, which is homologous to AcrB in E. coli. PMID:28137939 LpeB MdtNOP is a MFS efflux pump protein found in E. coli. The deletion of mdtP from strain W3110 resulted in increased susceptibility to acriflavin, puromycin, and tetraphenylarsonium chloride. An E. coli mdtN null mutant is more sensitive to sulfur drugs than wild type. MdtNOP sdsRQP ycjRQP antibiotic_resistance ARO:3004101 MdtNOP ARO:3004101 MdtNOP is a MFS efflux pump protein found in E. coli. The deletion of mdtP from strain W3110 resulted in increased susceptibility to acriflavin, puromycin, and tetraphenylarsonium chloride. An E. coli mdtN null mutant is more sensitive to sulfur drugs than wild type. PMID:19429622 PMID:8021163 MdtNOP Methyltransferase enzyme first described in Streptoalloteichus tenebrarius. Confers resistance to aminoglycoside antibiotics (esp. apramycin) through methylation of the 16S rRNA at A1408, thereby modifying the antibiotic target. kamB antibiotic_resistance ARO:3004102 kamB ARO:3004102 Methyltransferase enzyme first described in Streptoalloteichus tenebrarius. Confers resistance to aminoglycoside antibiotics (esp. apramycin) through methylation of the 16S rRNA at A1408, thereby modifying the antibiotic target. PMID:19589804 PMID:24963996 kamB QepA2 is a plasmid-mediated quinolone resistance pump found in an Escherichia coli isolate from France. QepA2 antibiotic_resistance ARO:3004103 QepA2 ARO:3004103 QepA2 is a plasmid-mediated quinolone resistance pump found in an Escherichia coli isolate from France. PMID:18644958 QepA2 TMB-1, the first known member of the Tripoli metallo-beta-lactamase family (TMB) was isolated from Achromobacter xylosoxidans in a Tripoli central hospital. TMB-1 was located on a class 1 integron and is a chromosomally-encoded beta-lactamase capable of hydrolyzing multiple antibiotics. antibiotic_resistance ARO:3004104 TMB beta-lactamase ARO:3004104 TMB-1, the first known member of the Tripoli metallo-beta-lactamase family (TMB) was isolated from Achromobacter xylosoxidans in a Tripoli central hospital. TMB-1 was located on a class 1 integron and is a chromosomally-encoded beta-lactamase capable of hydrolyzing multiple antibiotics. PMID:22290947 TMB-1 is a TMB metallo-beta-lactamase found in Achromobacter sp. TMB-1 antibiotic_resistance ARO:3004105 TMB-1 ARO:3004105 TMB-1 is a TMB metallo-beta-lactamase found in Achromobacter sp. PMID:22290947 TMB-1 TMB-2 is a TMB metallo-beta-lactamase found in Acinetobacter sp. TMB-2 antibiotic_resistance ARO:3004106 TMB-2 ARO:3004106 TMB-2 is a TMB metallo-beta-lactamase found in Acinetobacter sp. PMID:23390208 TMB-2 SoxR is a redox-sensitive transcriptional activator that induces expression of a small regulon that includes the RND efflux pump-encoding operon mexGHI-opmD. SoxR was shown to be activated by pyocyanin. Paer_soxR antibiotic_resistance ARO:3004107 Pseudomonas aeruginosa soxR ARO:3004107 SoxR is a redox-sensitive transcriptional activator that induces expression of a small regulon that includes the RND efflux pump-encoding operon mexGHI-opmD. SoxR was shown to be activated by pyocyanin. PMID:15845502 PMID:16879411 PMID:27274079 Paer_soxR rob is a positive regulator for the acrAB efflux genes, and is structurally similar to SoxS and MarA. Eclo_rob robA antibiotic_resistance ARO:3004108 Enterobacter cloacae rob ARO:3004108 rob is a positive regulator for the acrAB efflux genes, and is structurally similar to SoxS and MarA. PMID:23006750 Eclo_rob rob is a positive regulator for the acrAB efflux genes, and is structurally similar to SoxS and MarA. Ecol_rob robA antibiotic_resistance ARO:3004109 Escherichia coli rob ARO:3004109 rob is a positive regulator for the acrAB efflux genes, and is structurally similar to SoxS and MarA. PMID:12791142 PMID:9324261 Ecol_rob MCR-2 is a plasmid-borne phosphoethanolamine transferase that interferes with binding of colistin to the cell membrane via addition of phosphoethanolamine to lipid A, resulting in reduction of the negative charge of the cell membrane. Originally identified in a Belgian sample of Escherichia coli by Xavier et al, (2016). MCR-2 MCR-2.1 antibiotic_resistance ARO:3004110 MCR-2.1 ARO:3004110 MCR-2 is a plasmid-borne phosphoethanolamine transferase that interferes with binding of colistin to the cell membrane via addition of phosphoethanolamine to lipid A, resulting in reduction of the negative charge of the cell membrane. Originally identified in a Belgian sample of Escherichia coli by Xavier et al, (2016). PMID:27416987 PMID:28487432 PMID:30053115 MCR-2.1 FosA6 is a plasmid-encoded enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule. FosA6 antibiotic_resistance ARO:3004111 FosA6 ARO:3004111 FosA6 is a plasmid-encoded enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule. PMID:27261267 FosA6 This group of enzymes catalyzes the addition of a phosphoethanolamine group to another molecule. The addition of this moiety to lipid A in bacterial species is often associated with polymyxin (otherwise known as colistin) resistance. PEtN transferase antibiotic_resistance ARO:3004112 phosphoethanolamine transferase conferring colistin resistance ARO:3004112 This group of enzymes catalyzes the addition of a phosphoethanolamine group to another molecule. The addition of this moiety to lipid A in bacterial species is often associated with polymyxin (otherwise known as colistin) resistance. PMID:26603172 PMID:28487432 FosA7 is an enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule. FosA7 antibiotic_resistance ARO:3004113 FosA7 ARO:3004113 FosA7 is an enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule. PMID:28533247 FosA7 In the presence of antibiotic stress, there is a coupled down-regulation of the porin OmpC with the OmpF. Mutants both lacking both OmpC and OmpF proteins are resistant to cephaloridine and cefazolin. Analyses of genes involved in the increased resistance to tetracycline suggest that the up-regulation of efflux pump genes is accompanied by a decrease of OmpF and OmpC synthesis. Homologs of OmpC have been identified in Escherichia coli, Salmonella enterica, Klebsiella aerogenes and Serratia marcescens. porin_OmpC antibiotic_resistance ARO:3004114 porin OmpC ARO:3004114 In the presence of antibiotic stress, there is a coupled down-regulation of the porin OmpC with the OmpF. Mutants both lacking both OmpC and OmpF proteins are resistant to cephaloridine and cefazolin. Analyses of genes involved in the increased resistance to tetracycline suggest that the up-regulation of efflux pump genes is accompanied by a decrease of OmpF and OmpC synthesis. Homologs of OmpC have been identified in Escherichia coli, Salmonella enterica, Klebsiella aerogenes and Serratia marcescens. PMID:17426813 PMID:23034325 PMID:6760806 porin_OmpC Nitroimidazoles are a group of drugs that have both antiprotozoal and antibacterial activity, classified with respect to the location of the nitro functional group. antibiotic_resistance ARO:3004115 nitroimidazole antibiotic ARO:3004115 Nitrofurans are chemotherapeutic agents with antibacterial and antiprotozoal activity. antibiotic_resistance ARO:3004116 nitrofuran antibiotic ARO:3004116 A ToxR-Regulated outer membrane porin. In Vibrio cholerae, ToxR controls resistance to P2 (a BPI-derived antimicrobial peptide) by regulating the production of OmpU. OmpU also confers resistance to polymyxin B sulfate. Vcho_OmpU antibiotic_resistance ARO:3004117 Vibrio cholerae OmpU ARO:3004117 A ToxR-Regulated outer membrane porin. In Vibrio cholerae, ToxR controls resistance to P2 (a BPI-derived antimicrobial peptide) by regulating the production of OmpU. OmpU also confers resistance to polymyxin B sulfate. PMID:15155667 PMID:24943244 Vcho_OmpU A ToxR negatively regulated outer membrane porin. In Vibrio cholerae, ToxR controls resistance to P2 (a BPI-derived antimicrobial peptide) by regulating the production of OmpT, especially in the absence of OmpU. Vcho_OmpT antibiotic_resistance ARO:3004118 Vibrio cholerae OmpT ARO:3004118 A ToxR negatively regulated outer membrane porin. In Vibrio cholerae, ToxR controls resistance to P2 (a BPI-derived antimicrobial peptide) by regulating the production of OmpT, especially in the absence of OmpU. PMID:10632889 PMID:15155667 Vcho_OmpT CBP C1-aminomethylene vancomycin is a synthetic vancomycin derivative which exhibits multiple synergistic mechanisms of action, allowing it to effectively inhibit otherwise-glycopeptide resistant Gram-positive bacteria (notably those with functioning VanA clusters). antibiotic_resistance ARO:3004120 CBP C1-aminomethylene vancomycin ARO:3004120 CBP C1-aminomethylene vancomycin is a synthetic vancomycin derivative which exhibits multiple synergistic mechanisms of action, allowing it to effectively inhibit otherwise-glycopeptide resistant Gram-positive bacteria (notably those with functioning VanA clusters). PMID:28559345 Bactericidal/permeability-increasing (BPI) protein is a member of a new generation of proteins known as super-antibiotics that are implicated as endotoxin neutralising agents. The potent (nM) cytotoxicity of BPI is limited to gram-negative bacteria (GNB), reflecting the high affinity (<10 nM) of BPI for bacterial lipopolysaccharides (LPS). Binding of BPI to live bacteria via LPS causes immediate growth arrest, actual killing coincides with later damage to the inner membrane. PDB:1EWF antibiotic_resistance ARO:3004121 BPI ARO:3004121 Bactericidal/permeability-increasing (BPI) protein is a member of a new generation of proteins known as super-antibiotics that are implicated as endotoxin neutralising agents. The potent (nM) cytotoxicity of BPI is limited to gram-negative bacteria (GNB), reflecting the high affinity (<10 nM) of BPI for bacterial lipopolysaccharides (LPS). Binding of BPI to live bacteria via LPS causes immediate growth arrest, actual killing coincides with later damage to the inner membrane. PMID:28336464 PMID:9665269 Klebsiella pneumoniae outer membrane porin protein. Is preferentially detected in porin-deficient strains. Functional characterization of this new porin revealed a narrower pore than those of porins OmpK35 and OmpK36, which did not allow penetration by certain beta-lactams. Also, when a resistant strain expresses porin OmpK37 is less susceptible to cefotaxime and cefoxitin than when it is expressing either OmpK36 or OmpK35. Kpne_OmpK37 antibiotic_resistance ARO:3004122 Klebsiella pneumoniae OmpK37 ARO:3004122 Klebsiella pneumoniae outer membrane porin protein. Is preferentially detected in porin-deficient strains. Functional characterization of this new porin revealed a narrower pore than those of porins OmpK35 and OmpK36, which did not allow penetration by certain beta-lactams. Also, when a resistant strain expresses porin OmpK37 is less susceptible to cefotaxime and cefoxitin than when it is expressing either OmpK36 or OmpK35. PMID:10217760 Kpne_OmpK37 Heterologous expression of Burkholderia pseudomallei Omp38 (BpsOmp38) in Omp-deficient E. coli host cells lowers their permeability and in consequence, their antimicrobial susceptibility to penicillin G, cefoxitin, ceftazidime and imipenem. Bpse_Omp38 antibiotic_resistance ARO:3004123 Burkholderia pseudomallei Omp38 ARO:3004123 Heterologous expression of Burkholderia pseudomallei Omp38 (BpsOmp38) in Omp-deficient E. coli host cells lowers their permeability and in consequence, their antimicrobial susceptibility to penicillin G, cefoxitin, ceftazidime and imipenem. PMID:14567756 PMID:24788109 Bpse_Omp38 The outer membrane protein M35 of Moraxella catarrhalis is an antigenically conserved porin. Down-regulation of M35 significantly increases the MICs of aminopenicillins, specifically amoxicillin. Mcat_M35_AMX antibiotic_resistance ARO:3004124 Moraxella catarrhalis M35 ARO:3004124 The outer membrane protein M35 of Moraxella catarrhalis is an antigenically conserved porin. Down-regulation of M35 significantly increases the MICs of aminopenicillins, specifically amoxicillin. PMID:16159786 PMID:20801781 Mcat_M35_AMX Nucleotide point mutations in the 23S rRNA subunit may confer resistance to macrolide antibiotics. antibiotic_resistance ARO:3004125 23S rRNA with mutation conferring resistance to macrolide antibiotics ARO:3004125 Nucleotide point mutations in the 23S rRNA subunit may confer resistance to macrolide antibiotics. PMID:11120937 LamB is a negative regulator for antibiotic resistance, it serves as a porin to influx antibiotic. When down-regulated, it increases resistance to chlortetracycline, ciprofloxacin, balofloxacin and nalidixic acid. It also interacts with Odp1, an energy metabolic enzyme, creating a complex that decreases in antibiotic-resistant strains. Ecol_LamB antibiotic_resistance ARO:3004126 Escherichia coli LamB ARO:3004126 LamB is a negative regulator for antibiotic resistance, it serves as a porin to influx antibiotic. When down-regulated, it increases resistance to chlortetracycline, ciprofloxacin, balofloxacin and nalidixic acid. It also interacts with Odp1, an energy metabolic enzyme, creating a complex that decreases in antibiotic-resistant strains. PMID:10734605 PMID:18620846 PMID:24412198 Ecol_LamB MltA-interacting protein (mipA), is an antibiotic resistance-related outer membrane protein. Deletion of mipA increases kanamycin, nalidixic acid and streptomycin resistance. Ecol_mipA antibiotic_resistance ARO:3004127 Escherichia coli mipA ARO:3004127 MltA-interacting protein (mipA), is an antibiotic resistance-related outer membrane protein. Deletion of mipA increases kanamycin, nalidixic acid and streptomycin resistance. PMID:25940639 Ecol_mipA Omp1 is an outer membrane porin that confers resistance by absence in S. marcescens. Knockout, deletion or other inhibition of the omp1 gene confers resistance to certain beta-lactamase antibiotics - including Cefoxitin, Ceftriaxone, Cefotaxime, and Moxalactam - as well as Ciprofloxacin, Tetracycline, and Chloramphenicol, by preventing passage of the antibiotic into the cell. Smar_Omp1 antibiotic_resistance ARO:3004128 Serratia marcescens Omp1 ARO:3004128 Omp1 is an outer membrane porin that confers resistance by absence in S. marcescens. Knockout, deletion or other inhibition of the omp1 gene confers resistance to certain beta-lactamase antibiotics - including Cefoxitin, Ceftriaxone, Cefotaxime, and Moxalactam - as well as Ciprofloxacin, Tetracycline, and Chloramphenicol, by preventing passage of the antibiotic into the cell. PMID:25856195 PMID:9353750 Smar_Omp1 Cephaloridine is a semisynthetic, broad-spectrum, first-generation cephalosporin with antibacterial activity. Cephaloridine binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. CAS:50-59-9 ChEBI:3537 ChEMBL:CHEMBL316157 PubChem:5773 Cefaloridin Cefaloridine Cefalorizin Cephalomycine Cephaloridin Cephaloridinum Ceporin antibiotic_resistance ARO:3004129 cephaloridine ARO:3004129 Cephaloridine is a semisynthetic, broad-spectrum, first-generation cephalosporin with antibacterial activity. Cephaloridine binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. PMID:2907014 PMID:5175748 Balofloxacin is an 8-methoxy fluoroquinolone antibiotic. It shows potent bactericidal activity and inhibits the supercoiling activity of DNA gyrase of S. aureus, E. coli, and P. aeruginosa. CAS:127294-70-6 ChEBI:34553 ChEMBL:CHEMBL1210954 PubChem:65958 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methylaminopiperidine-1-yl)-4-oxoquinoline-3-carboxylic acid Q 35 Q-35 antibiotic_resistance ARO:3004130 balofloxacin ARO:3004130 Balofloxacin is an 8-methoxy fluoroquinolone antibiotic. It shows potent bactericidal activity and inhibits the supercoiling activity of DNA gyrase of S. aureus, E. coli, and P. aeruginosa. PMID:1329626 PMID:7492097 Point mutation in the 23S rRNA of Escherichia coli shown clinically to confer resistance to the macrolide-class antibiotics erythromycin and telithromycin. Ecol_23S_MULT antibiotic_resistance ARO:3004131 Escherichia coli 23S rRNA with mutation conferring resistance to erythromycin and telithromycin ARO:3004131 Point mutation in the 23S rRNA of Escherichia coli shown clinically to confer resistance to the macrolide-class antibiotics erythromycin and telithromycin. PMID:10027979 PMID:11120937 PMID:1569089 PMID:3886627 PMID:6330677 Ecol_23S_MULT Point mutation in 23S rRNA of C. reinhardtii chloroplast shown clinically to confer resistance to Erythromycin, a macrolide antibiotic. Crei_23S_ERY antibiotic_resistance ARO:3004132 Chlamydomonas reinhardtii 23S rRNA with mutation conferring resistance to erythromycin ARO:3004132 Point mutation in 23S rRNA of C. reinhardtii chloroplast shown clinically to confer resistance to Erythromycin, a macrolide antibiotic. PMID:11120937 PMID:2583478 Crei_23S_ERY Point mutation in B. hyodysenteriae 23S rRNA shown to confer resistance to tylosin and erythromycin. Bhyo_23S_TYL antibiotic_resistance ARO:3004133 Brachyspira hyodysenteriae 23S rRNA with mutation conferring resistance to tylosin ARO:3004133 Point mutation in B. hyodysenteriae 23S rRNA shown to confer resistance to tylosin and erythromycin. PMID:11120937 Bhyo_23S_TYL Point mutations in Helicobacter pylori shown to confer resistance to clarithromycin, a macrolide antibiotic. Hpyl_23S_CLR antibiotic_resistance ARO:3004134 Helicobacter pylori 23S rRNA with mutation conferring resistance to clarithromycin ARO:3004134 Point mutations in Helicobacter pylori shown to confer resistance to clarithromycin, a macrolide antibiotic. PMID:11120937 PMID:32708761 PMID:35002447 PMID:37485536 Hpyl_23S_CLR Point mutations in M. tuberculosis iniB shown to confer resistance to ethambutol. Mtub_iniB_EMB Rv0341 antibiotic_resistance ARO:3004135 Mycobacterium tuberculosis iniB with mutation conferring resistance to ethambutol ARO:3004135 Point mutations in M. tuberculosis iniB shown to confer resistance to ethambutol. PMID:10639358 Mtub_iniB_EMB Point mutations occurring in the iniB region of the iniBAC operon shown to confer resistance to ethambutol. antibiotic_resistance ARO:3004136 Ethambutol resistant iniB ARO:3004136 Point mutations occurring in the iniB region of the iniBAC operon shown to confer resistance to ethambutol. PMID:10639358 iniB, an isoniazid-induced protein, is part of the iniBAC operon that participates in the development of tolerance to both isoniazid and ethambutol. May function through a MDR-pump like mechanism, although it does not appear to directly transport isoniazid from the cell. antibiotic_resistance ARO:3004137 Antibiotic resistant iniB ARO:3004137 Point mutations in the 23S ribosomal RNA subunit of M. catarrhalis shown clinically to confer resistance to macrolide class antibiotics. Mcat_23S_MAC antibiotic_resistance ARO:3004138 Moraxella catarrhalis 23S rRNA with mutation conferring resistance to macrolide antibiotics ARO:3004138 Point mutations in the 23S ribosomal RNA subunit of M. catarrhalis shown clinically to confer resistance to macrolide class antibiotics. PMID:25923017 Mcat_23S_MAC MCR-3 is a plasmid-borne phosphoethanolamine transferase that interferes with binding of colistin to the cell membrane via addition of phosphoethanolamine to lipid A, resulting reduction in negative charge of the cell membrane. Originally described by Yin et al. 2017, from a porcine Escherichia coli plasmid pWJ1. MCR-3.1 antibiotic_resistance ARO:3004139 MCR-3.1 ARO:3004139 MCR-3 is a plasmid-borne phosphoethanolamine transferase that interferes with binding of colistin to the cell membrane via addition of phosphoethanolamine to lipid A, resulting reduction in negative charge of the cell membrane. Originally described by Yin et al. 2017, from a porcine Escherichia coli plasmid pWJ1. PMID:28655818 MCR-3.1 Enzymes shown to inactivate fusidic acid by hydrolytic cleavage from the 16 beta-position of fusidic acid and its derivatives. This converts fusidic acid to an inactivate lactone derivative, thus conferring resistance to fusidic acid. antibiotic_resistance ARO:3004140 hydrolysis of fusidic acid to inactive lactone derivative ARO:3004140 An RND-type efflux system that confers innate aminoglycoside resistance to Achromobacter spp. It has a transcriptional regulator encoded by the axyZ gene located upstream of axyXY-oprZ. In-frame axyZ gene deletion assay led to increased MICs of antibiotic substrates of the efflux system: aminoglycosides, cefepime, fluoroquinolones, tetracyclines and erythromycin, indicating that the product of axyZ negatively regulates expression of axyXY-oprZ. Moreover a 45 amino-acid substitution at position 29 of AxyZ (V29G) was identified in a clinical Achromobacter strain that occurred during the course of chronic respiratory tract colonization in a cystic fibrosis (CF) patient. This substitution, also detected in 3 other strains exposed in vitro to tobramycin, led to the increase in axyY transcription level (5 to 17-fold) together with the increase in antibiotic resistance level. antibiotic_resistance ARO:3004141 AxyXY-OprZ ARO:3004141 An RND-type efflux system that confers innate aminoglycoside resistance to Achromobacter spp. It has a transcriptional regulator encoded by the axyZ gene located upstream of axyXY-oprZ. In-frame axyZ gene deletion assay led to increased MICs of antibiotic substrates of the efflux system: aminoglycosides, cefepime, fluoroquinolones, tetracyclines and erythromycin, indicating that the product of axyZ negatively regulates expression of axyXY-oprZ. Moreover a 45 amino-acid substitution at position 29 of AxyZ (V29G) was identified in a clinical Achromobacter strain that occurred during the course of chronic respiratory tract colonization in a cystic fibrosis (CF) patient. This substitution, also detected in 3 other strains exposed in vitro to tobramycin, led to the increase in axyY transcription level (5 to 17-fold) together with the increase in antibiotic resistance level. PMID:28584156 OprZ is the outer membrane component of the AxyXY-OprZ efflux pump system in Achromobacter spp. OprZ antibiotic_resistance ARO:3004142 OprZ ARO:3004142 OprZ is the outer membrane component of the AxyXY-OprZ efflux pump system in Achromobacter spp. PMID:28584156 OprZ AxyX is the inner membrane transporter of the AxyXY-OprZ efflux pump system in Achromobacter spp. AxyX antibiotic_resistance ARO:3004143 AxyX ARO:3004143 AxyX is the inner membrane transporter of the AxyXY-OprZ efflux pump system in Achromobacter spp. PMID:28584156 AxyX AxyY is the periplasmic adaptor protein of the AxyXY-OprZ efflux pump system in Achromobacter spp. AxyY antibiotic_resistance ARO:3004144 AxyY ARO:3004144 AxyY is the periplasmic adaptor protein of the AxyXY-OprZ efflux pump system in Achromobacter spp. PMID:28584156 AxyY AxyZ is a transcriptional regulator of the AxyXY-OprZ efflux pump system. AxyZ antibiotic_resistance ARO:3004145 AxyZ ARO:3004145 AxyZ is a transcriptional regulator of the AxyXY-OprZ efflux pump system. PMID:28584156 AxyZ A cfr-like 23S rRNA methyltransferase shown to confer resistance to linezolid and phenicol antibiotics, including florfenicol and chloramphenicol, in Clostridium. cfr(C) cfrC antibiotic_resistance ARO:3004146 cfrC ARO:3004146 A cfr-like 23S rRNA methyltransferase shown to confer resistance to linezolid and phenicol antibiotics, including florfenicol and chloramphenicol, in Clostridium. PMID:28663118 cfrC Point mutation in the 23S rRNA of Escherichia coli shown clinically to confer resistance to clindamycin, a lincosamide antibiotic. Ecol_23S_CLI antibiotic_resistance ARO:3004149 Escherichia coli 23S rRNA with mutation conferring resistance to clindamycin ARO:3004149 Point mutation in the 23S rRNA of Escherichia coli shown clinically to confer resistance to clindamycin, a lincosamide antibiotic. PMID:1531223 Ecol_23S_CLI Point mutation in the 23S rRNA of Escherichia coli shown clinically to confer resistance to chloramphenicol. Ecol_23S_CHL antibiotic_resistance ARO:3004150 Escherichia coli 23S rRNA with mutation conferring resistance to chloramphenicol ARO:3004150 Point mutation in the 23S rRNA of Escherichia coli shown clinically to confer resistance to chloramphenicol. PMID:3886627 Ecol_23S_CHL Antibiotic resistant form of thymidylate synthase (synthetase), an enzyme that catalyzes the conversion of dUMP to dTMP in nucleotide biosynthesis. Loss-of-function mutations in thymidylate synthase confer resistance to p-aminosalicylic acid by disrupting the substrate-binding affinity and catalytic activity. antibiotic_resistance ARO:3004152 aminosalicylate resistant thymidylate synthase ARO:3004152 Point mutations in the thymidylate synthetase thyA gene shown clinically to confer resistance to para-aminosalicylic acid. Loss-of-function mutations in thyA disrupt the catalytic activity and substrate-binding affinity, thus conferring resistance. Mtub_thyA_PAS Rv2764c antibiotic_resistance ARO:3004153 Mycobacterium tuberculosis thyA with mutation conferring resistance to para-aminosalicylic acid ARO:3004153 Point mutations in the thymidylate synthetase thyA gene shown clinically to confer resistance to para-aminosalicylic acid. Loss-of-function mutations in thyA disrupt the catalytic activity and substrate-binding affinity, thus conferring resistance. PMID:25421465 PMID:35944069 Mtub_thyA_PAS Thymidylate synthase (synthetase) catalyzes the conversion of dUMP to dTMP in the nucleic acid biosynthesis pathway. Inhibition of thyA imbalances the cellular concentration of dUMP causing DNA damage. antibiotic sensitive thyA antibiotic_resistance ARO:3004154 antibiotic sensitive thymidylate synthase ARO:3004154 Thymidylate synthase (synthetase) catalyzes the conversion of dUMP to dTMP in the nucleic acid biosynthesis pathway. Inhibition of thyA imbalances the cellular concentration of dUMP causing DNA damage. PMID:25421465 Dihydrofolate synthase (synthetase) enzymes resistant to aminosalicylates (inc. para-aminosalicylic acid) caused by mutation. Dihydrofolate synthase is required for bioactivation of p-aminosalicylic acid, and mutation in dihydrofolate synthase inhibits production of the dihydrofolate analog hydroxyl-dihydrofolate, thus preventing activation and conferring resistance. antibiotic_resistance ARO:3004155 aminosalicylate resistant dihydrofolate synthase ARO:3004155 Wild-type form of dihydrofolate synthase (synthetase) enzymes. Bioactivation of p-aminosalicylic acid occurs during the folate pathway when dihydrofolate and its analog hydroxyl-dihydrofolate are produced by dihydrofolate synthase. Disruption of this pathway by PAS results in cell damage and death. antibiotic_resistance ARO:3004156 antibiotic sensitive dihydrofolate synthase ARO:3004156 Point mutations in the dihydrofolate synthetase folC gene shown clinically to confer resistance to p-aminosalicylic acid or other aminosalicylates. Mutations in folC inhibit bioactivation of PAS and thus confer resistance. Mtub_folC_PAS Rv2447c antibiotic_resistance ARO:3004157 Mycobacterium tuberculosis folC with mutation conferring resistance to para-aminosalicylic acid ARO:3004157 Point mutations in the dihydrofolate synthetase folC gene shown clinically to confer resistance to p-aminosalicylic acid or other aminosalicylates. Mutations in folC inhibit bioactivation of PAS and thus confer resistance. PMID:25421465 Mtub_folC_PAS Point mutations in the 23S rRNA (domain V) of Mycoplasma gallisepticum can confer resistance to pleuromutilin antibiotics (tiamulin and valnemulin). The mutants also show cross-resistance to lincomycin, chloramphenicol and florfenicol. Mgal_23S_PLM antibiotic_resistance ARO:3004159 Mycoplasma gallisepticum 23S rRNA mutation conferring resistance to pleuromutilin antibiotics ARO:3004159 Point mutations in the 23S rRNA (domain V) of Mycoplasma gallisepticum can confer resistance to pleuromutilin antibiotics (tiamulin and valnemulin). The mutants also show cross-resistance to lincomycin, chloramphenicol and florfenicol. PMID:19154331 PMID:20487023 Mgal_23S_PLM Point mutation in the 23S rRNA of Escherichia coli shown clinically to confer resistance to clarithromycin, a macrolide antibiotic. Ecol_23S_CLR antibiotic_resistance ARO:3004160 Escherichia coli 23S rRNA with mutation conferring resistance to clarithromycin ARO:3004160 Point mutation in the 23S rRNA of Escherichia coli shown clinically to confer resistance to clarithromycin, a macrolide antibiotic. PMID:1531223 Ecol_23S_CLR Point mutation in the 23S rRNA of Propionibacteria shown clinically to confer resistance to macrolides. Prop_23S_MAC antibiotic_resistance ARO:3004161 Propionibacteria 23S rRNA with mutation conferring resistance to macrolide antibiotics ARO:3004161 Point mutation in the 23S rRNA of Propionibacteria shown clinically to confer resistance to macrolides. PMID:9145890 Prop_23S_MAC Point mutation in the 23S rRNA of Mycobacteroides abscessus shown to confer resistance to clarithromycin, a macrolide type antibiotic. Mabs_23S_CLR antibiotic_resistance ARO:3004163 Mycobacteroides abscessus 23S rRNA with mutation conferring resistance to clarithromycin ARO:3004163 Point mutation in the 23S rRNA of Mycobacteroides abscessus shown to confer resistance to clarithromycin, a macrolide type antibiotic. PMID:27799212 PMID:8807061 Mabs_23S_CLR Point mutation in the 23S rRNA of Mycobacterium avium shown to confer resistance to clarithromycin, a macrolide type antibiotic. Mavi_23S_CLR antibiotic_resistance ARO:3004164 Mycobacterium avium 23S rRNA with mutation conferring resistance to clarithromycin ARO:3004164 Point mutation in the 23S rRNA of Mycobacterium avium shown to confer resistance to clarithromycin, a macrolide type antibiotic. PMID:8592991 Mavi_23S_CLR Point mutation in the 23S rRNA of Mycobacteroides chelonae shown to confer resistance to clarithromycin, a macrolide type antibiotic. Mche_23S_CLR antibiotic_resistance ARO:3004165 Mycobacteroides chelonae 23S rRNA with mutation conferring resistance to clarithromycin ARO:3004165 Point mutation in the 23S rRNA of Mycobacteroides chelonae shown to confer resistance to clarithromycin, a macrolide type antibiotic. PMID:11120937 PMID:8807061 Mche_23S_CLR Point mutation in the 23S rRNA of Mycobacterium intracellulare shown to confer resistance to clarithromycin, a macrolide type antibiotic. Mint_23S_CLR antibiotic_resistance ARO:3004166 Mycobacterium intracellulare 23S rRNA with mutation conferring resistance to clarithromycin ARO:3004166 Point mutation in the 23S rRNA of Mycobacterium intracellulare shown to confer resistance to clarithromycin, a macrolide type antibiotic. PMID:8192472 Mint_23S_CLR Point mutation in the 23S rRNA of Mycobaccterium avium shown to confer resistance to azithromycin, a macrolide type antibiotic. Mint_23S_AZM antibiotic_resistance ARO:3004167 Mycobacterium intracellulare 23S rRNA with mutation conferring resistance to azithromycin ARO:3004167 Point mutation in the 23S rRNA of Mycobaccterium avium shown to confer resistance to azithromycin, a macrolide type antibiotic. PMID:8192472 Mint_23S_AZM Point mutation in the 23S rRNA of Mycobacterium kansasii shown to confer resistance to clarithromycin, a macrolide type antibiotic. Mkan_23S_CLR antibiotic_resistance ARO:3004168 Mycobacterium kansasii 23S rRNA with mutation conferring resistance to clarithromycin ARO:3004168 Point mutation in the 23S rRNA of Mycobacterium kansasii shown to confer resistance to clarithromycin, a macrolide type antibiotic. PMID:9635911 Mkan_23S_CLR Point mutation in the 23S rRNA of Mycolicibacterium smegmatis shown to confer resistance to clarithromycin, a macrolide type antibiotic. Msme_23S_CLR antibiotic_resistance ARO:3004169 Mycolicibacterium smegmatis 23S rRNA with mutation conferring resistance to clarithromycin ARO:3004169 Point mutation in the 23S rRNA of Mycolicibacterium smegmatis shown to confer resistance to clarithromycin, a macrolide type antibiotic. PMID:9402018 Msme_23S_CLR Point mutation in the 23S rRNA of Streptococcus pneumoniae shown to confer resistance to macrolide type antibiotics. Spne_23S_MAC antibiotic_resistance ARO:3004170 Streptococcus pneumoniae 23S rRNA with mutation conferring resistance to macrolide antibiotics ARO:3004170 Point mutation in the 23S rRNA of Streptococcus pneumoniae shown to confer resistance to macrolide type antibiotics. PMID:10898684 Spne_23S_MAC Point mutation in the 23S rRNA of Streptomyces ambofaciens shown to confer resistance to macrolide type antibiotics. Samb_23S_MAC antibiotic_resistance ARO:3004171 Streptomyces ambofaciens 23S rRNA with mutation conferring resistance to macrolide antibiotics ARO:3004171 Point mutation in the 23S rRNA of Streptomyces ambofaciens shown to confer resistance to macrolide type antibiotics. PMID:2834204 Samb_23S_MAC Point mutations in the 23S rRNA subunit may confer resistance to oxazolidinone antibiotics. antibiotic_resistance ARO:3004172 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics ARO:3004172 Point mutations in the 23S rRNA subunit may confer resistance to oxazolidinone antibiotics. PMID:10986233 Point mutation in the 23S rRNA of Escherichia coli shown to confer resistance to oxazolidinone type antibiotics. Ecol_23S_OXZ antibiotic_resistance ARO:3004173 Escherichia coli 23S rRNA with mutation conferring resistance to oxazolidinone antibiotics ARO:3004173 Point mutation in the 23S rRNA of Escherichia coli shown to confer resistance to oxazolidinone type antibiotics. PMID:10986233 Ecol_23S_OXZ Point mutation in the 23S rRNA of Chlamydia trachomatis shown to confer resistance to macrolide type antibiotics. Ctra_23S_MAC antibiotic_resistance ARO:3004174 Chlamydia trachomatis 23S rRNA with mutation conferring resistance to macrolide antibiotics ARO:3004174 Point mutation in the 23S rRNA of Chlamydia trachomatis shown to confer resistance to macrolide type antibiotics. PMID:15047540 PMID:17908942 PMID:26622462 Ctra_23S_MAC Point mutation in the 23S rRNA of Mycoplasma hominis shown to confer resistance to macrolide type antibiotics. Mhom_23S_MAC antibiotic_resistance ARO:3004176 Mycoplasma hominis 23S rRNA with mutation conferring resistance to macrolide antibiotics ARO:3004176 Point mutation in the 23S rRNA of Mycoplasma hominis shown to confer resistance to macrolide type antibiotics. PMID:12234836 Mhom_23S_MAC Point mutation in the 23S rRNA of Mycoplasmopsis fermentans shown to confer resistance to macrolide type antibiotics. Mfer_23S_MAC antibiotic_resistance ARO:3004177 Mycoplasmopsis fermentans 23S rRNA with mutation conferring resistance to macrolide antibiotics ARO:3004177 Point mutation in the 23S rRNA of Mycoplasmopsis fermentans shown to confer resistance to macrolide type antibiotics. PMID:12234836 Mfer_23S_MAC Point mutations in the 23S rRNA subunit may confer resistance to pleuromutilin antibiotics. antibiotic_resistance ARO:3004178 23S rRNA with mutation conferring resistance to pleuromutilin antibiotics ARO:3004178 Point mutations in the 23S rRNA subunit may confer resistance to pleuromutilin antibiotics. PMID:19154331 PMID:20487023 Point mutation in the 23S rRNA of Mycoplasma pneumoniae shown to confer resistance to erythromycin. Mpne_23S_ERY antibiotic_resistance ARO:3004179 Mycoplasma pneumoniae 23S rRNA mutation conferring resistance to erythromycin ARO:3004179 Point mutation in the 23S rRNA of Mycoplasma pneumoniae shown to confer resistance to erythromycin. PMID:8593017 Mpne_23S_ERY Point mutation in the 23S rRNA of Halobacterium halobium shown to confer resistance to chloramphenicol. Hhal_23S_CHL antibiotic_resistance ARO:3004180 Halobacterium halobium 23S rRNA mutation conferring resistance to chloramphenicol ARO:3004180 Point mutation in the 23S rRNA of Halobacterium halobium shown to confer resistance to chloramphenicol. PMID:2045374 Hhal_23S_CHL Point mutation in the 23S rRNA of Streptococcus pneumoniae shown to confer resistance to macrolides and streptogramins types of antibiotics. Spne_23S_MULT antibiotic_resistance ARO:3004181 Streptococcus pneumoniae 23S rRNA mutation conferring resistance to macrolides and streptogramins antibiotics ARO:3004181 Point mutation in the 23S rRNA of Streptococcus pneumoniae shown to confer resistance to macrolides and streptogramins types of antibiotics. PMID:11120988 Spne_23S_MULT Nucleotide point mutations in the 23S rRNA subunit may confer resistance to streptogramins antibiotics. antibiotic_resistance ARO:3004182 23S rRNA with mutation conferring resistance to streptogramins antibiotics ARO:3004182 Nucleotide point mutations in the 23S rRNA subunit may confer resistance to streptogramins antibiotics. PMID:11120988 Antibiotic target replacement dihydrofolate reductase enzymes or domains with catalytic activity that confer resistance to aminosalicylates, esp. p-aminosalicylic acid. antibiotic_resistance ARO:3004183 aminosalicylate resistant dihydrofolate reductase ARO:3004183 ribD is a Mycobacterium tuberculosis riboflavin biosynthesis enzyme. Point mutations in ribD cause enzyme overexpression, which allows the C-terminal reductase domain to act as an alternative dihydrofolate reductase. Thus, mutations in ribD confer resistance to DHFR inhibitors such as para-aminosalicylic acid. Mtub_ribD_PAS Rv2671 antibiotic_resistance ARO:3004184 Mycobacterium tuberculosis ribD with mutation conferring resistance to para-aminosalicylic acid ARO:3004184 ribD is a Mycobacterium tuberculosis riboflavin biosynthesis enzyme. Point mutations in ribD cause enzyme overexpression, which allows the C-terminal reductase domain to act as an alternative dihydrofolate reductase. Thus, mutations in ribD confer resistance to DHFR inhibitors such as para-aminosalicylic acid. PMID:25421465 Mtub_ribD_PAS mecD is a PBP2a variant identified on a genomic resistance island in Macrococcus caseolyticus. MecD confers resistance to methicillin and other beta-lactam antibiotics through the production of an alternative low-affinity PBP. First described by Schwendener et al. 2017 and identified from canine and bovine sources. mecD antibiotic_resistance ARO:3004185 mecD ARO:3004185 mecD is a PBP2a variant identified on a genomic resistance island in Macrococcus caseolyticus. MecD confers resistance to methicillin and other beta-lactam antibiotics through the production of an alternative low-affinity PBP. First described by Schwendener et al. 2017 and identified from canine and bovine sources. PMID:28272476 mecD Point mutations in the 23S rRNA subunit may confer resistance to lincosamide antibiotics by reducing antibiotic binding-site affinity. antibiotic_resistance ARO:3004187 23S rRNA with mutation conferring resistance to lincosamide antibiotics ARO:3004187 Point mutations in the 23S rRNA subunit shown clinically to confer resistance to phenicol class antibiotics, including chloramphenicol and florfenicol, by disrupting antibiotic binding-site affinity. antibiotic_resistance ARO:3004188 23S rRNA with mutation conferring resistance to phenicol antibiotics ARO:3004188 Bla2 is a chromosomal-encoded beta-lactamase, found in Bacillus anthracis, which has penicillin, cephalosporin, and carbapenem-hydrolizing abilities. Bla2 antibiotic_resistance ARO:3004189 Bla2 ARO:3004189 Bla2 is a chromosomal-encoded beta-lactamase, found in Bacillus anthracis, which has penicillin, cephalosporin, and carbapenem-hydrolizing abilities. PMID:12533457 PMID:12760895 PMID:27557855 Bla2 BlaA beta-lactamases are Class A beta-lactamases first identified in Yersinia enterocolitica and have the ability to hydrolize penicilins and cephalosporins. antibiotic_resistance ARO:3004190 BlaA beta-lactamase ARO:3004190 BlaA beta-lactamases are Class A beta-lactamases first identified in Yersinia enterocolitica and have the ability to hydrolize penicilins and cephalosporins. PMID:11897607 PMID:16553870 PMID:1756974 PMID:237976 Aminoglycoside 2''-phosphotransferase identified from the gram-negative pathogen Campylobacter jejuni. APH(2'')-If was shown to confer resistance to 4,6-disubstituted antibiotics kanamycin, tobramycin, dibekacin, gentamicin and sisomicin through antibiotic phosphorylation. Described by Toth et al. 2013. APH(2'')-If antibiotic_resistance ARO:3004191 APH(2'')-If ARO:3004191 Aminoglycoside 2''-phosphotransferase identified from the gram-negative pathogen Campylobacter jejuni. APH(2'')-If was shown to confer resistance to 4,6-disubstituted antibiotics kanamycin, tobramycin, dibekacin, gentamicin and sisomicin through antibiotic phosphorylation. Described by Toth et al. 2013. PMID:23129050 APH(2'')-If CepA beta-lactamases are Class A beta-lactamases found in Bateroides fragilis and have the ability to hydrolyze cephalosporin. antibiotic_resistance ARO:3004192 CepA beta-lactamase ARO:3004192 CepA beta-lactamases are Class A beta-lactamases found in Bateroides fragilis and have the ability to hydrolyze cephalosporin. PMID:7517394 PMID:8285623 A plasmid-borne novel MCR-1 functional variant detected in a Klebsiella pneumoniae isolate collected from a rectal swab in Italy. MCR-1.2 differs from MCR-1 by a single amino acid substitution from Glutamine to Leucine at position 3 in the N-terminal region. Described by DiPilato et al. 2016. MCR-1.2 antibiotic_resistance ARO:3004194 MCR-1.2 ARO:3004194 A plasmid-borne novel MCR-1 functional variant detected in a Klebsiella pneumoniae isolate collected from a rectal swab in Italy. MCR-1.2 differs from MCR-1 by a single amino acid substitution from Glutamine to Leucine at position 3 in the N-terminal region. Described by DiPilato et al. 2016. PMID:27401575 MCR-1.2 VCC beta-lactamases are Class A beta-lactamases. antibiotic_resistance ARO:3004196 VCC beta-lactamase ARO:3004196 VCC beta-lactamases are Class A beta-lactamases. PMID:26824956 BlaZ beta-lactamases are Class A beta-lactamases. These beta-lactamases are responsible for penicillin resistance in Staphylococcus aureus. antibiotic_resistance ARO:3004197 BlaZ beta-lactamase ARO:3004197 BlaZ beta-lactamases are Class A beta-lactamases. These beta-lactamases are responsible for penicillin resistance in Staphylococcus aureus. PMID:26305782 PMID:6793593 R39 beta-lactamases are Class A beta-lactamases encoded in Actinomadura R39 with the ability to hydrolyze penicillins. antibiotic_resistance ARO:3004198 R39 beta-lactamase ARO:3004198 R39 beta-lactamases are Class A beta-lactamases encoded in Actinomadura R39 with the ability to hydrolyze penicillins. PMID:2515104 CepS beta-lactamases are Class C beta-lactamases capable of hydrolyzing cephalosporin. antibiotic_resistance ARO:3004199 CepS beta-lactamase ARO:3004199 CepS beta-lactamases are Class C beta-lactamases capable of hydrolyzing cephalosporin. PMID:8537283 CfiA beta-lactamases are chromosomal-encoded carbapenemase commonly found in Bacteroides fragilis isolates. antibiotic_resistance ARO:3004200 CfiA beta-lactamase ARO:3004200 CfiA beta-lactamases are chromosomal-encoded carbapenemase commonly found in Bacteroides fragilis isolates. PMID:1510410 BlaB beta-lactamases are class B beta-lactamases that are found in a variety of species and have the ability to hydrolyze penams and carbapenems. antibiotic_resistance ARO:3004201 BlaB beta-lactamase ARO:3004201 JOHN beta-lactamases hydrolyse penicillins, narrow- and expanded-spectrum cephalosporins, and carbapenems. antibiotic_resistance ARO:3004202 JOHN beta-lactamase ARO:3004202 JOHN beta-lactamases hydrolyse penicillins, narrow- and expanded-spectrum cephalosporins, and carbapenems. PMID:12562690 CGB beta-lactamases are Class B beta-lactamases found in Chryseobacterium gleu that can hydrolyze penicillins; narrow- and expanded-spectrum cephalosporins; and carbapenems. antibiotic_resistance ARO:3004203 CGB beta-lactamase ARO:3004203 CGB beta-lactamases are Class B beta-lactamases found in Chryseobacterium gleu that can hydrolyze penicillins; narrow- and expanded-spectrum cephalosporins; and carbapenems. PMID:12183230 EBR beta-lactamases are Class B beta-lactamases first isolated from Empedobacter brevis and are able to hydrolyze penicillins, cephalosporins, and carbapenems. antibiotic_resistance ARO:3004204 EBR beta-lactamase ARO:3004204 EBR beta-lactamases are Class B beta-lactamases first isolated from Empedobacter brevis and are able to hydrolyze penicillins, cephalosporins, and carbapenems. PMID:12234848 TUS beta-lactamases are Class B beta-lactamases that can hydrolyze a variety of beta-lactams, such as cephems and carbapenems. antibiotic_resistance ARO:3004205 TUS beta-lactamase ARO:3004205 TUS beta-lactamases are Class B beta-lactamases that can hydrolyze a variety of beta-lactams, such as cephems and carbapenems. PMID:12384365 PMID:24031236 SIM beta-lactamases are Class B beta-lactamases that are capable of hydrolyzing a wide variety of beta-lactams, including penicillins, narrow- to expanded-spectrum cephalosporins, and carbapenem. The SIM family of beta-lactamases appear to be transferable through integrons. antibiotic_resistance ARO:3004206 SIM beta-lactamase ARO:3004206 SIM beta-lactamases are Class B beta-lactamases that are capable of hydrolyzing a wide variety of beta-lactams, including penicillins, narrow- to expanded-spectrum cephalosporins, and carbapenem. The SIM family of beta-lactamases appear to be transferable through integrons. PMID:16251286 PMID:20498315 KHM beta-lactamases are Class B beta-lactamases that can confer resistance to all classes of beta-lactams, except the monobactams. antibiotic_resistance ARO:3004207 KHM beta-lactamase ARO:3004207 DIM type beta-lactamases were first identified from a carbapenem-resistant Pseudomonas stutzeri strain isolated from a Dutch patient. Encoded in mobile elements, these MBLs significantly hydrolyze broad-spectrum cephalosporins and carbapenems. antibiotic_resistance ARO:3004208 DIM beta-lactamase ARO:3004208 DIM type beta-lactamases were first identified from a carbapenem-resistant Pseudomonas stutzeri strain isolated from a Dutch patient. Encoded in mobile elements, these MBLs significantly hydrolyze broad-spectrum cephalosporins and carbapenems. PMID:20308383 First identified from a multi-drug resistant Pseudomonas aeruginosa clinical isolate in 2012, HMB type beta-lactamases can be encoded in transposons and hydrolyze carbapenems. antibiotic_resistance ARO:3004209 HMB beta-lactamase ARO:3004209 First identified from a multi-drug resistant Pseudomonas aeruginosa clinical isolate in 2012, HMB type beta-lactamases can be encoded in transposons and hydrolyze carbapenems. PMID:28065891 This type of Subclass B2 beta-lactamases was first identified from a Serratia fonticola environmental isolate. antibiotic_resistance ARO:3004210 SFH beta-lactamase ARO:3004210 This type of Subclass B2 beta-lactamases was first identified from a Serratia fonticola environmental isolate. PMID:12821491 The FEZ family of beta-lactamases are subclass B3 beta-lactamases that hydrolyze penicillins, cephalosporins, and carbapenems. antibiotic_resistance ARO:3004211 FEZ beta-lactamase ARO:3004211 The FEZ family of beta-lactamases are subclass B3 beta-lactamases that hydrolyze penicillins, cephalosporins, and carbapenems. PMID:18563261 The GOB family of beta-lactamases have been discovered in the Elizabethkingia meningoseptica and are classified as subclass B3 beta-lactamase. They confer resistance to cephalosporins, penicillins, and carbapenems. antibiotic_resistance ARO:3004212 GOB beta-lactamase ARO:3004212 The GOB family of beta-lactamases have been discovered in the Elizabethkingia meningoseptica and are classified as subclass B3 beta-lactamase. They confer resistance to cephalosporins, penicillins, and carbapenems. PMID:10858348 PMID:17403673 PMID:27458232 GOB-18 is a member of subclass B3 GOB family of beta-lactamases isolated from Elizabethkingia meningoseptica. GOB-18 is unlike other subclass B3 beta-lactamases as it is fully active against a broad range of beta-lactam substrates using a single Zn(II) ion in its active site. GOB-18 antibiotic_resistance ARO:3004213 GOB-18 ARO:3004213 GOB-18 is a member of subclass B3 GOB family of beta-lactamases isolated from Elizabethkingia meningoseptica. GOB-18 is unlike other subclass B3 beta-lactamases as it is fully active against a broad range of beta-lactam substrates using a single Zn(II) ion in its active site. PMID:17403673 PMID:27458232 GOB-18 Beta-lactamases that are part of the THIN-B family, which is a subclass B3 beta-lactamase family and hydrolyze a broad spectrum of beta-lactams including penicillins, cephalosporins, and carbapenems. antibiotic_resistance ARO:3004214 THIN-B beta-lactamase ARO:3004214 Beta-lactamases that are part of the THIN-B family, which is a subclass B3 beta-lactamase family and hydrolyze a broad spectrum of beta-lactams including penicillins, cephalosporins, and carbapenems. PMID:11181369 PMID:15561856 This subclass B3 of beta-lactamses have the ability to hydrolyze cephalosporins. antibiotic_resistance ARO:3004215 L1 family beta-lactamase ARO:3004215 This subclass B3 of beta-lactamses have the ability to hydrolyze cephalosporins. PMID:9811546 A subclass B3 family of beta-lactamases that confer resistance to a range of beta-lactam antibiotics including penams, cephamycins, and cephalosporins. antibiotic_resistance ARO:3004216 AIM beta-lactamase ARO:3004216 A subclass B3 family of beta-lactamases that confer resistance to a range of beta-lactam antibiotics including penams, cephamycins, and cephalosporins. PMID:22664968 SMB beta-lactamases are a subclass B3 beta-lactamases that hydrolyze a variety of beta-lactams, including penicillins, cephalosporins, and carbapenems. antibiotic_resistance ARO:3004217 SMB beta-lactamase ARO:3004217 SMB beta-lactamases are a subclass B3 beta-lactamases that hydrolyze a variety of beta-lactams, including penicillins, cephalosporins, and carbapenems. PMID:22442240 CAU beta-lactamases are a subclass B3 family. antibiotic_resistance ARO:3004218 CAU beta-lactamase ARO:3004218 CAU beta-lactamases are a subclass B3 family. PMID:12019096 BJP beta-lactamases are a subclass B3 family. antibiotic_resistance ARO:3004219 BJP beta-lactamase ARO:3004219 BJP beta-lactamases are a subclass B3 family. PMID:16723554 PEDO family enzymes that are classified under subclass B3 (metallo-) beta-lactamases. antibiotic_resistance ARO:3004220 subclass B3 PEDO beta-lactamase ARO:3004220 CPS beta-lactamases are a subclass B3 family. antibiotic_resistance ARO:3004221 CPS beta-lactamase ARO:3004221 ESP family beta-lactamases are subclass B3 (metallo-) beta-lactamases. antibiotic_resistance ARO:3004222 ESP beta-lactamase ARO:3004222 ESP family beta-lactamases are subclass B3 (metallo-) beta-lactamases. PMID:26482314 MSI beta-lactamases are a family of subclass B3 (metallo-) beta-lactamases. antibiotic_resistance ARO:3004223 MSI beta-lactamase ARO:3004223 MSI beta-lactamases are a family of subclass B3 (metallo-) beta-lactamases. PMID:26482314 SPG beta-lactamases are a family of subclass B3 (metallo-) beta-lactamases. antibiotic_resistance ARO:3004224 SPG beta-lactamase ARO:3004224 SPG beta-lactamases are a family of subclass B3 (metallo-) beta-lactamases. PMID:26482314 A family encompassing subclass B3 Rm3-like beta-lactamases. antibiotic_resistance ARO:3004225 Rm3 family beta-lactamase ARO:3004225 A family encompassing subclass B3 Rm3-like beta-lactamases. PMID:27431213 Beta-lactamases that are part of the LRA gene family and are classified as B3 (metallo-) beta-lactamases. antibiotic_resistance ARO:3004226 subclass B3 LRA beta-lactamase ARO:3004226 Beta-lactamases that are part of the LRA gene family and are classified as B3 (metallo-) beta-lactamases. PMID:18843302 Beta-lactamases that are part of the PEDO gene family and are classified as subclass B1 (metallo-) beta-lactamases. antibiotic_resistance ARO:3004227 subclass B1 PEDO beta-lactamase ARO:3004227 Beta-lactamases that are part of the PEDO gene family and are classified as subclass B1 (metallo-) beta-lactamases. PMID:26482314 Beta-lactamases that are part of the LRA gene family and are classified as Class A beta-lactamases. antibiotic_resistance ARO:3004228 class A LRA beta-lactamase ARO:3004228 Beta-lactamases that are part of the LRA gene family and are classified as Class A beta-lactamases. PMID:18843302 Beta-lactamases belonging to the Bla genes from Bacillus anthracis that are classified as class A beta-lactamases. antibiotic_resistance ARO:3004229 class A Bacillus anthracis Bla beta-lactamase ARO:3004229 Beta-lactamases belonging to the Bla genes from Bacillus anthracis that are classified as class A beta-lactamases. PMID:12760895 Beta-lactamases belonging to the Bla genes from Bacillus anthracis that are classified as subclass B1 beta-lactamases. antibiotic_resistance ARO:3004230 subclass B1 Bacillus anthracis Bla beta-lactamase ARO:3004230 Beta-lactamases belonging to the Bla genes from Bacillus anthracis that are classified as subclass B1 beta-lactamases. PMID:12760895 Beta-lactamases that are part of the LRA gene family and are classified as Class C beta-lactamases. antibiotic_resistance ARO:3004231 class C LRA beta-lactamase ARO:3004231 Beta-lactamases that are part of the LRA gene family and are classified as Class C beta-lactamases. PMID:18843302 AmpC beta-lactamases are clinically important class C beta-lactamase enzymes which confer resistance to cephalosporins and penicillin-like antibiotics. AmpC beta-lactamases are typically found in Enterobacteriaceae, and were described in Escherichia coli in 1940 as the first reported enzymatic deactivation of penicillin. The name AmpC connects these enzymes functionally across many species, however these enzymes are generally unnamed and not phylogenetically related. antibiotic_resistance ARO:3004232 ampC-type beta-lactamase ARO:3004232 AmpC beta-lactamases are clinically important class C beta-lactamase enzymes which confer resistance to cephalosporins and penicillin-like antibiotics. AmpC beta-lactamases are typically found in Enterobacteriaceae, and were described in Escherichia coli in 1940 as the first reported enzymatic deactivation of penicillin. The name AmpC connects these enzymes functionally across many species, however these enzymes are generally unnamed and not phylogenetically related. PMID:21304033 Class A Beta-lactamases first isolated from Mycolicibacterium fortuitum. antibiotic_resistance ARO:3004233 blaF family beta-lactamase ARO:3004233 Class A Beta-lactamases first isolated from Mycolicibacterium fortuitum. PMID:8065266 Beta-lactamases part of this family discovered in Streptomyces albus G. antibiotic_resistance ARO:3004234 EXO beta-lactamase ARO:3004234 Beta-lactamases part of this family discovered in Streptomyces albus G. PMID:2658780 A family of class A beta-lactamases that have been discovered in the Rhodobacter genus. antibiotic_resistance ARO:3004235 RCP beta-lactamase ARO:3004235 A family of class A beta-lactamases that have been discovered in the Rhodobacter genus. PMID:2783689 PMID:2788410 This family of macrolide glycosyltransferases derive from gimA, which was discovered in Streptomyces ambofaciens. antibiotic_resistance ARO:3004236 gimA family macrolide glycosyltransferase ARO:3004236 This family of macrolide glycosyltransferases derive from gimA, which was discovered in Streptomyces ambofaciens. PMID:9756764 The mgt family encompasses macrolide glycotransferases of the Streptomyces genus. antibiotic_resistance ARO:3004237 mgt macrolide glycotransferase ARO:3004237 The mgt family encompasses macrolide glycotransferases of the Streptomyces genus. PMID:1605601 PMID:1612452 The sul genes encode forms of dihydropteroate synthase that confer resistance to sulfonamide. antibiotic_resistance ARO:3004238 sulfonamide resistant sul ARO:3004238 The sul genes encode forms of dihydropteroate synthase that confer resistance to sulfonamide. PMID:15673783 NPS-1 is a plasmid-encoded class D beta-lactamases identified from two Pseudomonas aeruginosa isolates in 1986. NPS-1 antibiotic_resistance ARO:3004239 NPS-1 ARO:3004239 NPS-1 is a plasmid-encoded class D beta-lactamases identified from two Pseudomonas aeruginosa isolates in 1986. PMID:11557499 PMID:3089139 NPS-1 NPS beta-lactamases are class D beta-lactamases that have partial hydrolyzing abilities against penicillins and cephalosporin. antibiotic_resistance ARO:3004240 NPS beta-lactamase ARO:3004240 Beta-lactamases that are part of the LRA gene family and are classified as Class D beta-lactamases. antibiotic_resistance ARO:3004241 class D LRA beta-lactamase ARO:3004241 Beta-lactamases that are part of the LRA gene family and are classified as Class D beta-lactamases. PMID:18843302 Members of the MSI-OXA family are class D beta-lactamases that encompass hybrids of MSI-1 and putative OXA homologues. antibiotic_resistance ARO:3004242 MSI-OXA family beta-lactamase ARO:3004242 Members of the MSI-OXA family are class D beta-lactamases that encompass hybrids of MSI-1 and putative OXA homologues. PMID:26482314 RbpA is a family of bacterial RNA polymerase-binding proteins, which acts as a transcription factor and binds to the sigma subunit of RNA polymerase. antibiotic_resistance ARO:3004243 RbpA bacterial RNA polymerase-binding protein ARO:3004243 RbpA is a family of bacterial RNA polymerase-binding proteins, which acts as a transcription factor and binds to the sigma subunit of RNA polymerase. PMID:16629670 PMID:22570422 The DnaA family of replication initiation proteins interact with RNA polymerase to confer resistance against rifampicin anitibiotics. antibiotic_resistance ARO:3004244 DnaA chromosomal replication initiation protein ARO:3004244 The DnaA family of replication initiation proteins interact with RNA polymerase to confer resistance against rifampicin anitibiotics. PMID:19170875 PMID:21527473 The fosC family of phosphotransferases phosphorylate fosfomycin to confer resistance and have been found in various bacterial isolates. antibiotic_resistance ARO:3004245 fosC phosphotransferase family ARO:3004245 The fosC family of phosphotransferases phosphorylate fosfomycin to confer resistance and have been found in various bacterial isolates. PMID:20404116 PMID:7492106 Two members of the Fom family have been identified, FomA and FomB. FomB must interact with FomA confer resistance to fosfomycin, however FomA is capable of conferring resistance alone. antibiotic_resistance ARO:3004246 Fom phosphotransferase family ARO:3004246 Fosfomycin is transported bacterial cells through transporters, one of them being glycerol-3-phosphate, which is encoded by the GlpT gene. Mutations in the GlpT gene can confer resistance to fosfomycin. antibiotic_resistance ARO:3004247 antibiotic-resistant GlpT ARO:3004247 UhpT encodes a transporter that can import fosfomycin-type drugs into bacterial cells. Mutations to UhpT confer resistance. antibiotic_resistance ARO:3004248 antibiotic-resistant UhpT ARO:3004248 UhpT encodes a transporter that can import fosfomycin-type drugs into bacterial cells. Mutations to UhpT confer resistance. PMID:28579984 UhpA acts as a positive regulator of UhpT, which is a transporter to bring fosfomycin drugs into bacterial cells. Mutations in UhpA that negatively impact the expression of UhpT can confer resistance. antibiotic_resistance ARO:3004249 UhpA ARO:3004249 UhpA acts as a positive regulator of UhpT, which is a transporter to bring fosfomycin drugs into bacterial cells. Mutations in UhpA that negatively impact the expression of UhpT can confer resistance. PMID:19671590 PMID:20071153 PtsI family phosphotransferases are involved in cyclic AMP synthesis, which regulates glpT expression. Mutations in PtsI family genes can negatively affect expression of UhpT, which is needed for fosfomycin import. antibiotic_resistance ARO:3004250 antibiotic-resistant ptsI phosphotransferase ARO:3004250 PtsI family phosphotransferases are involved in cyclic AMP synthesis, which regulates glpT expression. Mutations in PtsI family genes can negatively affect expression of UhpT, which is needed for fosfomycin import. PMID:20071153 Adenylate cyclases encoded by cya genes, which are involved in the synthesis cyclic AMP which regulates the fosfomycin transporter glpT. Mutations in cya genes can confer resistance to fosfomycin. antibiotic_resistance ARO:3004251 antibiotic-resistant cya adenylate cyclase ARO:3004251 Adenylate cyclases encoded by cya genes, which are involved in the synthesis cyclic AMP which regulates the fosfomycin transporter glpT. Mutations in cya genes can confer resistance to fosfomycin. PMID:14519998 Also known as vanUG, is a vanG variant found in the vanG gene cluster. vanU-G vanUG vanU_in_vanG_cl antibiotic_resistance ARO:3004253 vanU gene in vanG cluster ARO:3004253 Also known as vanUG, is a vanG variant found in the vanG gene cluster. PMID:11036060 PMID:14617152 PMID:16723588 vanU_in_vanG_cl Also known as vanVB, is a vanV variant found in the vanB gene cluster. It is found in some but not all vanB operons in E. faecalis, suggesting the existence of varied gene compositions in vanB operons. vanV-B vanVB vanV_in_vanB_cl antibiotic_resistance ARO:3004254 vanV gene in vanB cluster ARO:3004254 Also known as vanVB, is a vanV variant found in the vanB gene cluster. It is found in some but not all vanB operons in E. faecalis, suggesting the existence of varied gene compositions in vanB operons. PMID:21482081 vanV_in_vanB_cl vanJ and vanJ homologue proteins confer resistance to teicoplanin. antibiotic_resistance ARO:3004255 vanJ membrane protein ARO:3004255 vanJ and vanJ homologue proteins confer resistance to teicoplanin. PMID:22232274 Bleomycin resistant proteins (BRP) confer resistance to bleomycin and to bleomycin-like molecules. antibiotic_resistance ARO:3004256 Bleomycin resistant protein ARO:3004256 Bleomycin resistant proteins (BRP) confer resistance to bleomycin and to bleomycin-like molecules. PMID:18791008 PMID:22290943 Acetyltransferases of the cpa family confer resistance to capreomycin, an aminoglycoside antibiotic. antibiotic_resistance ARO:3004257 cpa acetyltransferase ARO:3004257 Acetyltransferases of the cpa family confer resistance to capreomycin, an aminoglycoside antibiotic. PMID:27929110 Bah amidohydrolases are membrane proteins that inactivate bacitracin. antibiotic_resistance ARO:3004260 Bah amidohydrolase ARO:3004260 Bah amidohydrolases are membrane proteins that inactivate bacitracin. PMID:27929110 Viomycin family of phosphotransferases confer resistance to viomycin antibiotics. antibiotic_resistance ARO:3004261 viomycin phosphotransferase ARO:3004261 Viomycin family of phosphotransferases confer resistance to viomycin antibiotics. PMID:2987648 Mutations to the liaF accessory protein that confer resistance to daptomycin. antibiotic_resistance ARO:3004262 daptomycin resistant liaF ARO:3004262 Mutations to the liaF accessory protein that confer resistance to daptomycin. PMID:21899450 Mutations to the liaR response regulator that confer resistance to daptomycin. antibiotic_resistance ARO:3004263 daptomycin resistant liaR ARO:3004263 Mutations in the liaS histidine kinase that confer daptomycin resistance. antibiotic_resistance ARO:3004264 daptomycin resistant liaS ARO:3004264 Mutations in the liaS histidine kinase that confer daptomycin resistance. PMID:21899450 Mutations to demA confer lycosin resistance. antibiotic_resistance ARO:3004265 lysocin resistant menA ARO:3004265 Mutations to demA confer lycosin resistance. PMID:25485686 Point mutations in katG confer antibiotic resistance by preventing katG from catalyzing the activation of antibiotics. antibiotic_resistance ARO:3004266 antibiotic resistant katG ARO:3004266 Point mutations in katG confer antibiotic resistance by preventing katG from catalyzing the activation of antibiotics. PMID:23744165 Point mutations in pncA prevent the enzyme from activating antibiotics, such as pyrazinamide. antibiotic_resistance ARO:3004267 antibiotic resistant pncA ARO:3004267 Point mutations in pncA prevent the enzyme from activating antibiotics, such as pyrazinamide. PMID:9055989 A group of mobile colistin resistance genes encode the MCR family of phosphoethanolamine transferases, which catalyze the addition of phosphoethanolamine onto lipid A, thus interfering with the binding of colistin to the cell membrane. antibiotic_resistance ARO:3004268 MCR phosphoethanolamine transferase ARO:3004268 A group of mobile colistin resistance genes encode the MCR family of phosphoethanolamine transferases, which catalyze the addition of phosphoethanolamine onto lipid A, thus interfering with the binding of colistin to the cell membrane. PMID:26603172 PMID:27401575 PMID:28487432 PMID:28655818 This family of phosphoethanolamine transferase catalyze the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine to lipid A, which impedes the binding of colistin to the cell membrane. antibiotic_resistance ARO:3004269 pmr phosphoethanolamine transferase ARO:3004269 This family of phosphoethanolamine transferase catalyze the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine to lipid A, which impedes the binding of colistin to the cell membrane. PMID:15205413 PMID:9570402 fabI is a enoyl-acyl carrier reductase used in lipid metabolism and fatty acid biosynthesis. The bacterial biocide Triclosan blocks the final reduction step in fatty acid elongation, inhibiting biosynthesis. Point mutations in fabI can confer resistance to Triclosan and Isoniazid. antibiotic_resistance ARO:3004270 antibiotic resistant fabI ARO:3004270 fabI is a enoyl-acyl carrier reductase used in lipid metabolism and fatty acid biosynthesis. The bacterial biocide Triclosan blocks the final reduction step in fatty acid elongation, inhibiting biosynthesis. Point mutations in fabI can confer resistance to Triclosan and Isoniazid. PMID:27577999 Methyltransferases that methylate the G1405 position of 16S rRNA, which is part of an aminoglycoside binding site. antibiotic_resistance ARO:3004271 16S rRNA methyltransferase (G1405) ARO:3004271 Methyltransferases that methylate the G1405 position of 16S rRNA, which is part of an aminoglycoside binding site. PMID:21177880 Methyltransferases that methylate the A1408 position of 16S rRNA, which is part of an aminoglycoside binding site. antibiotic_resistance ARO:3004272 16S rRNA methyltransferase (A1408) ARO:3004272 Methyltransferases that methylate the A1408 position of 16S rRNA, which is part of an aminoglycoside binding site. PMID:17875999 PMID:19589804 A family of lincosamide resistant 23S rRNA methyltransferases. The only member of the family discovered so far was isolated from Paenibacillus sp. LC231, a strain found in Lechuguilla Cave, NM, USA. antibiotic_resistance ARO:3004273 Llm 23S ribosomal RNA methyltransferase ARO:3004273 A family of lincosamide resistant 23S rRNA methyltransferases. The only member of the family discovered so far was isolated from Paenibacillus sp. LC231, a strain found in Lechuguilla Cave, NM, USA. PMID:27929110 Methyltransferases that modify the 23S rRNA of the 50S subunit of bacterial ribosomes, conferring resistance to drugs that target 23S rRNA. antibiotic_resistance ARO:3004274 23S ribosomal RNA methyltransferase ARO:3004274 Methyltransferases that modify the 23S rRNA of the 50S subunit of bacterial ribosomes, conferring resistance to drugs that target 23S rRNA. PMID:20144045 PMID:20618865 PMID:7590303 A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 3''-hydroxyl group of the compound. antibiotic_resistance ARO:3004275 ANT(3'') ARO:3004275 A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 3''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 3''-hydroxyl group of the compound. PMID:20833577 A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 2''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 2''-hydroxyl group of the compound. antibiotic_resistance ARO:3004276 ANT(2'') ARO:3004276 A category of aminoglycoside O-nucleotidyltransferase enzymes with modification regiospecificity based at the 2''-hydroxyl group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics by transfer of an AMP group from an ATP substrate to the 2''-hydroxyl group of the compound. PMID:25564464 General bacterial porins are a family of porins found in the outer membrane of Gram-negative bacteria. They catalyze the energy-independent transport of small molecules across the outer membranes of bacteria. Most of the porins of these family are homotrimeric and have variable selectivity, ranging from being cation-selective, anion-selective or selective for different compounds. The most well characterized members of this family are the OmpF and OmpC porins of Escherichia coli. This family is also known as the classical porins. antibiotic_resistance ARO:3004277 General Bacterial Porin (GBP) ARO:3004277 General bacterial porins are a family of porins found in the outer membrane of Gram-negative bacteria. They catalyze the energy-independent transport of small molecules across the outer membranes of bacteria. Most of the porins of these family are homotrimeric and have variable selectivity, ranging from being cation-selective, anion-selective or selective for different compounds. The most well characterized members of this family are the OmpF and OmpC porins of Escherichia coli. This family is also known as the classical porins. PMID:18997824 The Opr family consists of porins in Pseudomonas species, and other Gram-negative bacteria, that exhibit a variety of substrate selectivities. antibiotic_resistance ARO:3004278 Outer Membrane Porin (Opr) ARO:3004278 The Opr family consists of porins in Pseudomonas species, and other Gram-negative bacteria, that exhibit a variety of substrate selectivities. PMID:18997824 Members of the Sugar Porin family tend to facilitate the transport of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. These porins form a homotrimeric structure. antibiotic_resistance ARO:3004279 Sugar Porin (SP) ARO:3004279 The MltA-interacting Protein (MipA) family consists mainly of homologs to MipA and OmpV proteins. Proteins of this family, are predicted to form a beta-barrel. antibiotic_resistance ARO:3004280 MipA-interacting Protein ARO:3004280 These are GBPs that are associated with decreased susceptibility to beta-lactams either through mutations in the porin protein, absence of the porin protein, or expression of the porin protein. antibiotic_resistance ARO:3004281 General Bacterial Porin with reduced permeability to beta-lactams ARO:3004281 These are GBPs that are associated with decreased susceptibility to peptide antibiotics either through mutations in the porin protein, absence of the porin protein, or expression of the porin protein. antibiotic_resistance ARO:3004282 General Bacterial Porin with reduced permeability to peptide antibiotics ARO:3004282 The imipenum resistance-associated CarO porin family is composed of the CarO porin originally identified in Acinetobacter baumannii. The loss of these porins is associated with imipenem and meropenem multi-drug resistance. The channels formed by CarO porins show slight cation selectivity. antibiotic_resistance ARO:3004283 CarO porin ARO:3004283 fabG is a 3-oxoacyl-acyl carrier protein reductase involved in lipid metabolism and fatty acid biosynthesis. The bacterial biocide Triclosan blocks the final reduction step in fatty acid elongation, inhibiting biosynthesis. Point mutations in fabG can confer resistance to Triclosan. antibiotic_resistance ARO:3004284 antibiotic resistant fabG ARO:3004284 A grouping of tunicamycin resistance proteins that are homologous to tmrB found in Bacillus subtilis. antibiotic_resistance ARO:3004285 tunicamycin resistance protein ARO:3004285 A grouping of tunicamycin resistance proteins that are homologous to tmrB found in Bacillus subtilis. PMID:1624425 Phenotypic variant regulator proteins play a role in controlling the switch between antibiotic-susceptible and antibiotic-resistant forms of bacteria. The characterized member of this family is the PvrR protein in Pseudomonas aeruginosa, which when absent, confers antibiotic resistance. antibiotic_resistance ARO:3004286 phenotypic variant regulator ARO:3004286 Phenotypic variant regulator proteins play a role in controlling the switch between antibiotic-susceptible and antibiotic-resistant forms of bacteria. The characterized member of this family is the PvrR protein in Pseudomonas aeruginosa, which when absent, confers antibiotic resistance. PMID:22195037 The antimicrobial activity of certain antibiotics, such as peptide antibiotics, is proposed to be initiated through binding to the lipid A moiety of lipopolysaccharides. Thus, covalent modification of Gram-negative bacterial lipid A by phosphatases is a mechanism to reduce the susceptibility of the bacteria to antibiotics. antibiotic_resistance ARO:3004287 lipid A phosphatase ARO:3004287 varG is an Ambler class B metallo-beta-lactamase found on the antibiotic resistance var regulon in Vibrio cholerae, along with an antibiotic efflux pump varABCDEF. These genes are organized as a regulon under the control of VarR transcriptional activator. VarG was shown to have beta-lactamase activity against penicillins, carbapenems and cephalosporins in-vitro. antibiotic_resistance ARO:3004288 Subclass B1 Vibrio cholerae varG beta-lactamase ARO:3004288 varG is an Ambler class B metallo-beta-lactamase found on the antibiotic resistance var regulon in Vibrio cholerae, along with an antibiotic efflux pump varABCDEF. These genes are organized as a regulon under the control of VarR transcriptional activator. VarG was shown to have beta-lactamase activity against penicillins, carbapenems and cephalosporins in-vitro. PMID:28898293 varG is an Ambler class B metallo-beta-lactamase found on the antibiotic resistance var regulon in Vibrio cholerae, along with an antibiotic efflux pump varABCDEF. These genes are organized as a regulon under the control of VarR transcriptional activator. VarG was shown to have beta-lactamase activity against penicillins, carbapenems and cephalosporins in-vitro. Described by Lin HV et al. 2017. Vcho_varG antibiotic_resistance ARO:3004289 Vibrio cholerae varG ARO:3004289 varG is an Ambler class B metallo-beta-lactamase found on the antibiotic resistance var regulon in Vibrio cholerae, along with an antibiotic efflux pump varABCDEF. These genes are organized as a regulon under the control of VarR transcriptional activator. VarG was shown to have beta-lactamase activity against penicillins, carbapenems and cephalosporins in-vitro. Described by Lin HV et al. 2017. PMID:28898293 Vcho_varG A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. Ecol_ampC_BLA antibiotic_resistance ARO:3004290 Escherichia coli ampC beta-lactamase ARO:3004290 A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics. PMID:19136439 PMID:3055168 Ecol_ampC_BLA A periplasmic cephalosporinase described in Rhodobacter sphaeroides shown to contribute to resistance of beta-lactam antibiotics. Rsph_ampC_BLA antibiotic_resistance ARO:3004291 Rhodobacter sphaeroides ampC beta-lactamase ARO:3004291 A periplasmic cephalosporinase described in Rhodobacter sphaeroides shown to contribute to resistance of beta-lactam antibiotics. PMID:2783689 Rsph_ampC_BLA A class C beta-lactamase family of chromosome-encoded antibiotic resistance genes originally described from Buttiauxella spp. antibiotic_resistance ARO:3004293 BUT beta-lactamase ARO:3004293 A class C beta-lactamase family of chromosome-encoded antibiotic resistance genes originally described from Buttiauxella spp. PMID:12127496 A chromosome-encoded class C cephalosporinase and penicillinase from Buttiauxella spp. shown clinically to confer resistance to beta-lactam antibiotics. Described by Fihman et al. 2002. BUT-1 antibiotic_resistance ARO:3004294 BUT-1 ARO:3004294 A chromosome-encoded class C cephalosporinase and penicillinase from Buttiauxella spp. shown clinically to confer resistance to beta-lactam antibiotics. Described by Fihman et al. 2002. PMID:12127496 BUT-1 A ribosomally synthesized cyclic peptide antibiotic. Lassomycin has been shown to be effective against drug-resistant mycobacteria but shows little activity against other bacteria. Lassomycin targets and binds to a region of the ClpC1 ATPase complex and uncouples ATPase from proteolytic activity, an essential function for mycobacterial viability, causing cell death. PubChem:132528125 antibiotic_resistance ARO:3004295 lassomycin ARO:3004295 A ribosomally synthesized cyclic peptide antibiotic. Lassomycin has been shown to be effective against drug-resistant mycobacteria but shows little activity against other bacteria. Lassomycin targets and binds to a region of the ClpC1 ATPase complex and uncouples ATPase from proteolytic activity, an essential function for mycobacterial viability, causing cell death. PMID:24684906 Bulgecin A is a lytic transglycosylase inhibitor and antibiotic potentiator produced from Pseudomonas mesoacidophila. In the presence of some beta-lactam antibiotics, including ampicillin and meropenem, bulgecin A has been shown to restore susceptibility to carbapenems in carbapenem-resistant pathogens. ChEMBL:CHEMBL1231509 PubChem:444940 antibiotic_resistance ARO:3004296 bulgecin A ARO:3004296 Bulgecin A is a lytic transglycosylase inhibitor and antibiotic potentiator produced from Pseudomonas mesoacidophila. In the presence of some beta-lactam antibiotics, including ampicillin and meropenem, bulgecin A has been shown to restore susceptibility to carbapenems in carbapenem-resistant pathogens. PMID:27703329 Qualitative description of a microbial response to antimicrobial agents and the expected clinical outcome. Bacteria may be susceptible or resistant to a broad range of antibiotic drugs or drug classes, with several intermediate states or phases. antibiotic_resistance ARO:3004299 antimicrobial phenotype ARO:3004299 Intermediate sensitivity of a bacterial strain to a given antibiotic occurs when it is inhibited by a concentration of the drug that is associated with uncertain therapeutic effect. The elimination of intermediate phenotype bacteria may depend on the site of infection and/or the concentration of the administered drug. Definition from https://clsi.org. antibiotic_resistance ARO:3004300 intermediate antimicrobial phenotype ARO:3004300 A bacterial strain is said to be resistant to a given antibiotic when it is inhibited in vitro by a concentration of this drug that is associated with a high likelihood of therapeutic failure. antibiotic_resistance ARO:3004301 resistant antimicrobial phenotype ARO:3004301 A bacterial strain is said to be resistant to a given antibiotic when it is inhibited in vitro by a concentration of this drug that is associated with a high likelihood of therapeutic failure. PMID:19626213 A bacterial strain is said to be susceptible to a given antibiotic when it is inhibited in vitro by a concentration of a drug that is associated with a high likelihood of therapeutic success. antibiotic_resistance ARO:3004302 susceptible antimicrobial phenotype ARO:3004302 A bacterial strain is said to be susceptible to a given antibiotic when it is inhibited in vitro by a concentration of a drug that is associated with a high likelihood of therapeutic success. PMID:19626213 A bacterial strain is said to be nonsusceptible to a given antibiotic drug if it demonstrates either an intermediate or resistant phenotype when exposed to a concentration of a drug that is associated with a high likelihood of therapeutic failure, i.e. if the bacterial strain is not susceptible to the antibiotic drug but not necessarily totally resistant under all conditions. Definition from https://clsi.org. nonsensitive antimicrobial phenotype antibiotic_resistance ARO:3004303 nonsusceptible antimicrobial phenotype ARO:3004303 A bacterial strain is said to be susceptible-dose dependent (SDD) to a given antibiotic when growth is inhibited with a high likelihood of therapeutic success, but when multiple approved dosing options exist. When a higher or more frequent dose is used, the predicted therapeutic result is the same as for susceptible individuals. SDD Sensitive dose dependent antimicrobial phenotype antibiotic_resistance ARO:3004304 susceptible dose dependent antimicrobial phenotype ARO:3004304 Multidrug-resistant organisms are defined as bacterial strains that have become resistant to multiple classes of antibacterial drugs or other agents. The phenotype of these organisms is defined by the spectrum of antibiotic drug classes to which that organism is resistant. Often, these organisms are susceptible to a narrow range of available drugs, making treatment difficult and urgent. MDRO antibiotic_resistance ARO:3004305 multidrug resistance antimicrobial phenotype ARO:3004305 Multidrug-resistant organisms are defined as bacterial strains that have become resistant to multiple classes of antibacterial drugs or other agents. The phenotype of these organisms is defined by the spectrum of antibiotic drug classes to which that organism is resistant. Often, these organisms are susceptible to a narrow range of available drugs, making treatment difficult and urgent. PMID:19626213 Any strain of Staphylococcus aureus that has tested resistant (R) to at least one of methicillin, oxacillin or cefoxitin by standard susceptibility testing methods. MRSA antibiotic_resistance ARO:3004306 methicillin-resistant Staphylococcus aureus ARO:3004306 Methicillin-resistant Staphylococcus aureus that has additionally tested resistant to the antibiotic drug linezolid. antibiotic_resistance ARO:3004307 Linezolid-resistant MRSA ARO:3004307 Methicillin-resistant Staphylococcus aureus that has additionally tested resistant to the fluoroquinolone antibiotics ciprofloxacin and/or levofloxacin. antibiotic_resistance ARO:3004308 Fluoroquinolone-resistant MRSA ARO:3004308 Methicillin-resistant Staphylococcus aureus that has additionally tested intermediate to vancomycin antibiotics. antibiotic_resistance ARO:3004309 Vancomycin-intermediate MRSA ARO:3004309 Methicillin-resistant Staphylococcus aureus that has additionally tested non-susceptible (NS, resistant or intermediate) to daptomycin antibiotics. antibiotic_resistance ARO:3004310 Daptomycin-resistant MRSA ARO:3004310 Any strain of Acinetobacter spp. that has tested either Intermediate or Resistant to at least one of the following carbapenem-class antibiotics by standard testing using approved breakpoints: imipenem, meropenem, doripenem. antibiotic_resistance ARO:3004311 carbapenem-resistant Acinetobacter ARO:3004311 Any strain of an Acinetobacter spp. that has either tested Intermediate or Resistant to at least one antibiotic drug in at least 3 of the 6 following categories: 1) Extended-spectrum cephalosporins, 2) Fluoroquinolone, 3) Aminoglycosides, 4) Carbapenems, 5) Piperacillin group, and 6) Ampicillin/sulbactam. antibiotic_resistance ARO:3004312 multidrug-resistant Acinetobacter ARO:3004312 Any strain of E. coli that has tested resistant to one of the following carbapenem antibiotics: imipenem, meropenem, doripenem, ertapenem. antibiotic_resistance ARO:3004313 carbapenem-resistant Escherichia coli ARO:3004313 Any E.coli that has tested resistant (R) to at least one of the following: ceftriaxone, ceftazidime, cefepime, and cefotaxime. antibiotic_resistance ARO:3004314 extended-spectrum cephalosporin-resistant Escherichia coli ARO:3004314 Any E.coli that has tested resistant (R) to at least one of the following: ciprofloxacin, levofloxacin, and moxifloxacin. antibiotic_resistance ARO:3004315 fluoroquinolone-resistant Escherichia coli ARO:3004315 Any E.coli that has tested either intermediate (I) or resistant (R) to at least one drug in at least 3 of the following 5 categories: 1) Extended-spectrum cephalosporins, 2) Fluoroquinolones (ciprofloxacin, levofloxacin, moxifloxacin), 3) Aminoglycosides (amikacin, gentamicin, tobramycin), 4) Carbapenems (imipenem, meropenem, doripenem, ertapenem), 5) Piperacillin Group (piperacillin, piperacillin/tazobactam). antibiotic_resistance ARO:3004316 multidrug-resistant Escherichia coli ARO:3004316 Any Enterobacter spp. that has tested resistant to at least one of the following antibiotic drugs: imipenem, meropenem, doripenem, ertapenem. antibiotic_resistance ARO:3004317 carbapenem-resistant Enterobacter ARO:3004317 Any Enterobacter spp. that has tested resistant to at least one of the following antibiotics: ceftriaxone, ceftazidime, cefepime, and/or cefotaxime. antibiotic_resistance ARO:3004318 extended-spectrum cephalosporin-resistant Enterobacter ARO:3004318 Any Enterobacter spp. that has tested either Intermediate or Resistant to at least one drug in at least 3 of the following categories: extended-spectrum cephalosporins, fluoroquinolones, aminoglycosides, carbapenems, and/or pipericillin/tazobactam. antibiotic_resistance ARO:3004319 multidrug-resistant Enterobacter ARO:3004319 Any Klebsiella oxytoca or Klebsiella pneumoniae that has tested resistant to at least one of the following antibiotics: imipenem, meropenem, doripenem, ertapenem. antibiotic_resistance ARO:3004320 carbapenem-resistant Klebsiella ARO:3004320 Any Klebsiella oxytoca or Klebsiella pneumoniae that has tested resistant to at least one of the following antibiotics: ceftriaxone, ceftazidime, cefepime, and/or cefotaxime. antibiotic_resistance ARO:3004321 extended-spectrum cephalosporin-resistant Klebsiella ARO:3004321 Any Klebsiella oxytoca or Klebsiella pneumoniae that has tested Intermediate or Resistant in at least 3 of the following categories: extended-spectrum cephalosporins, fluoroquinolones, aminoglycosides, carbapenems, or pipericillin/tazobactam. antibiotic_resistance ARO:3004322 multidrug-resistant Klebsiella ARO:3004322 Any strain of Pseudomonas aeruginosa that has tested either Intermediate or Resistant to at least one of the following antibiotics: imipenem, meropenem and/or doripenem. antibiotic_resistance ARO:3004323 carbapenem-resistant Pseudomonas aeruginosa ARO:3004323 Any strain of Pseudomonas aeruginosa that has tested Resistant to at least one of the following antibiotics: cefepime and/or ceftazidime. antibiotic_resistance ARO:3004324 extended-spectrum cephalosporin-resistant Pseudomonas aeruginosa ARO:3004324 MCR-4 is a plasmid-borne phosphoethanolamine transferase variant of MCR-1, isolated from Salmonella enterica serovar Typhimurium of porcine origin in Italy, Spain and Belgium through 2013 and 2015-2016. MCR-4 confers resistance to collistin via addition of a phosphoethanolamine group to lipid A, reducing the negative charge of the cell membrane. Described by Carattoli et al. 2017. MCR-4 MCR-4.1 antibiotic_resistance ARO:3004325 MCR-4.1 ARO:3004325 MCR-4 is a plasmid-borne phosphoethanolamine transferase variant of MCR-1, isolated from Salmonella enterica serovar Typhimurium of porcine origin in Italy, Spain and Belgium through 2013 and 2015-2016. MCR-4 confers resistance to collistin via addition of a phosphoethanolamine group to lipid A, reducing the negative charge of the cell membrane. Described by Carattoli et al. 2017. PMID:28797329 MCR-4.1 Any Pseudomonas aeruginosa that has tested resistant (R) to at least one of the following: ciprofloxacin, levofloxacin. antibiotic_resistance ARO:3004326 fluoroquinolone-resistant Pseudomonas aeruginosa ARO:3004326 Any Pseudomonas aeruginosa that has tested resistant (R) to at least one of the following: amikacin, gentamicin, tobramycin. antibiotic_resistance ARO:3004327 aminoglycoside-resistant Pseudomonas aeruginosa ARO:3004327 Any Pseudomonas aeruginosa that has tested resistant (R) to at least one of the following: piperacillin, piperacillin/tazobactam. antibiotic_resistance ARO:3004328 pipericillin-resistant Pseudomonas aeruginosa ARO:3004328 Any Enterococcus faecium or Enterococcus faecalis that has tested resistant (R) to vancomycin. VRE antibiotic_resistance ARO:3004329 vancomycin-resistant Enterococcus ARO:3004329 Any Enterococcus faecium or Enterococcus faecalis that has tested non-susceptible (NS) to daptomycin. antibiotic_resistance ARO:3004330 daptomycin-resistant Enterococcus ARO:3004330 Coagulase-Negative Staphylococci that has tested resistant(R) or intermediate(I) to vancomycin. antibiotic_resistance ARO:3004331 vancomycin-resistant coagulase-negative Staphylococci ARO:3004331 MCR-5 is a transposon-associated phosphoethanolamine transferase gene, identified in Salmonella Paratyphi B dTa+ (d-tartrate fermenting Salmonella enterica subsp. enterica serovar Paratyphi B) isolates from food-producing animals. The isolates were collected between 2011 and 2013, and retrieved from the German National Reference Laboratory for Salmonella. MCR-5 confers resistance to collistin through the addition of a phosphoethanolamine group to lipid A, causing a reduction in negative charge of the cell membrane. Described by Borowiak et al, 2017. MCR-5.1 antibiotic_resistance ARO:3004332 MCR-5.1 ARO:3004332 MCR-5 is a transposon-associated phosphoethanolamine transferase gene, identified in Salmonella Paratyphi B dTa+ (d-tartrate fermenting Salmonella enterica subsp. enterica serovar Paratyphi B) isolates from food-producing animals. The isolates were collected between 2011 and 2013, and retrieved from the German National Reference Laboratory for Salmonella. MCR-5 confers resistance to collistin through the addition of a phosphoethanolamine group to lipid A, causing a reduction in negative charge of the cell membrane. Described by Borowiak et al, 2017. PMID:28962028 PMID:30053115 MCR-5.1 DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Point mutations in gyrA have been shown to decrease susceptibility to the antibiotic triclosan. Although the mechanism is unclear, it is hypothesized that changes in supercoiling activity of mutant DNA gyrase proteins alters expression of stress response pathways thereby indirectly decreasing triclosan susceptibility. It has been shown that triclosan does not interact directly with gyrA. antibiotic_resistance ARO:3004333 triclosan resistant gyrA ARO:3004333 DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Point mutations in gyrA have been shown to decrease susceptibility to the antibiotic triclosan. Although the mechanism is unclear, it is hypothesized that changes in supercoiling activity of mutant DNA gyrase proteins alters expression of stress response pathways thereby indirectly decreasing triclosan susceptibility. It has been shown that triclosan does not interact directly with gyrA. PMID:29091182 Point mutations in Salmonella enterica serovar Typhimurium which have been shown to increase the minimum inhibitory concentration of the antibiotic triclosan. It is hypothesized that decreased susceptibility to triclosan in Salmonella gyrA mutants occurs indirectly due to alterations in the stress response pathways. Sent_gyrA_TRC antibiotic_resistance ARO:3004334 Salmonella enterica gyrA with mutation conferring resistance to triclosan ARO:3004334 Point mutations in Salmonella enterica serovar Typhimurium which have been shown to increase the minimum inhibitory concentration of the antibiotic triclosan. It is hypothesized that decreased susceptibility to triclosan in Salmonella gyrA mutants occurs indirectly due to alterations in the stress response pathways. PMID:29091182 Sent_gyrA_TRC Point mutations in Escherichia coli which have been shown to increase the minimum inhibitory concentration of the antibiotic triclosan. It is hypothesized that decreased susceptibility to triclosan in E. coli gyrA mutants occurs indirectly due to alterations in the stress response pathways. Ecol_gyrA_TRC antibiotic_resistance ARO:3004335 Escherichia coli gyrA with mutation conferring resistance to triclosan ARO:3004335 Point mutations in Escherichia coli which have been shown to increase the minimum inhibitory concentration of the antibiotic triclosan. It is hypothesized that decreased susceptibility to triclosan in E. coli gyrA mutants occurs indirectly due to alterations in the stress response pathways. PMID:29091182 Ecol_gyrA_TRC An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-73 antibiotic_resistance ARO:3004336 PDC-73 ARO:3004336 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-73 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-74 antibiotic_resistance ARO:3004337 PDC-74 ARO:3004337 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-74 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-75 antibiotic_resistance ARO:3004338 PDC-75 ARO:3004338 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-75 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-76 antibiotic_resistance ARO:3004339 PDC-76 ARO:3004339 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-76 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-77 antibiotic_resistance ARO:3004340 PDC-77 ARO:3004340 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-77 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-78 antibiotic_resistance ARO:3004341 PDC-78 ARO:3004341 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-78 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-79 antibiotic_resistance ARO:3004342 PDC-79 ARO:3004342 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-79 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-80 antibiotic_resistance ARO:3004343 PDC-80 ARO:3004343 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-80 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-81 antibiotic_resistance ARO:3004344 PDC-81 ARO:3004344 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-81 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-82 antibiotic_resistance ARO:3004345 PDC-82 ARO:3004345 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-82 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-83 antibiotic_resistance ARO:3004346 PDC-83 ARO:3004346 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-83 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-84 antibiotic_resistance ARO:3004347 PDC-84 ARO:3004347 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-84 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-85 antibiotic_resistance ARO:3004348 PDC-85 ARO:3004348 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-85 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-86 antibiotic_resistance ARO:3004349 PDC-86 ARO:3004349 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-86 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-87 antibiotic_resistance ARO:3004350 PDC-87 ARO:3004350 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-87 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-88 antibiotic_resistance ARO:3004351 PDC-88 ARO:3004351 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-88 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-89 antibiotic_resistance ARO:3004352 PDC-89 ARO:3004352 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-89 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-90 antibiotic_resistance ARO:3004353 PDC-90 ARO:3004353 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-90 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-91 antibiotic_resistance ARO:3004354 PDC-91 ARO:3004354 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-91 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-92 antibiotic_resistance ARO:3004355 PDC-92 ARO:3004355 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-92 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PDC-93 antibiotic_resistance ARO:3004356 PDC-93 ARO:3004356 An AmpC-like beta-lactamase found in Pseudomonas aeruginosa. PMID:26248364 PDC-93 A chloramphenicol acetyltransferase identified in Brevibacillus brevis and shown to confer resistance to chloramphenicol antibiotics. Described by Pawlowski et al. 2017. catV antibiotic_resistance ARO:3004357 catV ARO:3004357 A chloramphenicol acetyltransferase identified in Brevibacillus brevis and shown to confer resistance to chloramphenicol antibiotics. Described by Pawlowski et al. 2017. PMID:29259290 catV A family of class A beta-lactamase enzymes described in the gram-negative cocci Acidaminococcus fermentans. antibiotic_resistance ARO:3004358 ACI beta-lactamase ARO:3004358 A family of class A beta-lactamase enzymes described in the gram-negative cocci Acidaminococcus fermentans. PMID:11036038 A class A beta-lactamase described in Acidaminococcus fermentans. ACI-1 was the first description of a beta-lactamase enzyme in a gram-negative anaerobic cocci. Described by Galan et al 2000. ACI-1 antibiotic_resistance ARO:3004359 ACI-1 ARO:3004359 A class A beta-lactamase described in Acidaminococcus fermentans. ACI-1 was the first description of a beta-lactamase enzyme in a gram-negative anaerobic cocci. Described by Galan et al 2000. PMID:11036038 PMID:30014616 ACI-1 Uses breakpoints to create standards for interpreting the clinical outcome of an MIC value for a particular microbial species and antimicrobial agent. antibiotic_resistance ARO:3004360 antimicrobial resistance testing reference standard ARO:3004360 sul4 is a dihydropteroate synthase gene and mobile sulfonamide resistance gene shown to confer resistance when expressed in E. coli. sul4 antibiotic_resistance ARO:3004361 sul4 ARO:3004361 sul4 is a dihydropteroate synthase gene and mobile sulfonamide resistance gene shown to confer resistance when expressed in E. coli. PMID:29246178 sul4 A chromosome-carried OXA-48-like beta-lactamase, OXA-535, identified in Shewanella spp. JAB-1. Likely the progenitor to the plasmid-carried OXA-436. Expression of OXA-535 in E. coli demonstrated carbapenem-hydrolyzing activity. Described by Jousset et al. 2017. OXA-535 antibiotic_resistance ARO:3004362 OXA-535 ARO:3004362 OXA-535 Lipid A acyltransferase genes confer resistance to certain types of peptide antibiotics such as polymyxins through the aminoacylation of lipopolysaccharide, thereby decreasing the negative charge of the outer membrane surface. antibiotic_resistance ARO:3004363 lipid A acyltransferase ARO:3004363 Lipid A acyltransferase genes confer resistance to certain types of peptide antibiotics such as polymyxins through the aminoacylation of lipopolysaccharide, thereby decreasing the negative charge of the outer membrane surface. PMID:29101229 A member of the AlmEFG operon, responsible for polymyxin resistance in Vibrio cholerae. AlmG is a glycyltransferase closely related to lipid A acyltransferases. Described by Henderson JC et al. 2017. almG antibiotic_resistance ARO:3004364 almG ARO:3004364 A member of the AlmEFG operon, responsible for polymyxin resistance in Vibrio cholerae. AlmG is a glycyltransferase closely related to lipid A acyltransferases. Described by Henderson JC et al. 2017. PMID:29101229 almG BSAC is a British inter-professional organisation involved in antibiotic education, research and leadership. Baquero F. found that the BSAC system recommends lower breakpoints than the consensus standard of all systems for antimicrobial susceptibility testing used in Europe (BSAC, DIN, SFM, SIR, NCCLS and WRG). antibiotic_resistance ARO:3004365 British Society for Antimicrobial Chemotherapy (BSAC) ARO:3004365 BSAC is a British inter-professional organisation involved in antibiotic education, research and leadership. Baquero F. found that the BSAC system recommends lower breakpoints than the consensus standard of all systems for antimicrobial susceptibility testing used in Europe (BSAC, DIN, SFM, SIR, NCCLS and WRG). PMID:2226478 The Clinical and Laboratory Standards Institute develops and implements clinical laboratory testing standards. National Committee for Clinical Laboratory Standards (NCCLS) antibiotic_resistance ARO:3004366 Clinical and Laboratory Standards Institute (CLSI) ARO:3004366 The Clinical and Laboratory Standards Institute develops and implements clinical laboratory testing standards. PMID:11977864 DIN is recognized by the Federal Government of Germany as the competent standards organization for Germany and as the national standards body representing Germany in non-governmental international standards organizations. Baquero F. found that the DIN system recommends lower breakpoints than the consensus standard of all systems for antimicrobial susceptibility testing used in Europe (BSAC, DIN, SFM, SIR, NCCLS and WRG). antibiotic_resistance ARO:3004367 Deutsches Institut für Normung (DIN) ARO:3004367 DIN is recognized by the Federal Government of Germany as the competent standards organization for Germany and as the national standards body representing Germany in non-governmental international standards organizations. Baquero F. found that the DIN system recommends lower breakpoints than the consensus standard of all systems for antimicrobial susceptibility testing used in Europe (BSAC, DIN, SFM, SIR, NCCLS and WRG). PMID:2226478 EUCAST is a standing committee jointly organized by ESCMID, ECDC and European national breakpoint committees; it deals with breakpoints and technical aspects of phenotypic in-vitro antimicrobial susceptibility testing. antibiotic_resistance ARO:3004368 European Committee on Antimicrobial Susceptibility Testing (EUCAST) ARO:3004368 The French Society of Microbiology (SFM) is a non-profit association which aims to bring together microbiologists from French-speaking countries, working in the domains of bacteria, viruses, Fungi and parasites, and related medical, industrial and environmental microbiology, physiology, genetics, taxonomy, hygiene, and antimicrobial agents. Baquero F. found that the SFM system recommends higher breakpoints than the consensus standard of all systems for antimicrobial susceptibility testing used in Europe (BSAC, DIN, SFM, SIR, NCCLS and WRG). antibiotic_resistance ARO:3004369 Société Française de Microbiologie (SFM) ARO:3004369 The French Society of Microbiology (SFM) is a non-profit association which aims to bring together microbiologists from French-speaking countries, working in the domains of bacteria, viruses, Fungi and parasites, and related medical, industrial and environmental microbiology, physiology, genetics, taxonomy, hygiene, and antimicrobial agents. Baquero F. found that the SFM system recommends higher breakpoints than the consensus standard of all systems for antimicrobial susceptibility testing used in Europe (BSAC, DIN, SFM, SIR, NCCLS and WRG). PMID:2226478 Minimum inhibitory concentration (MIC), in microbiology, is the lowest concentration of an antimicrobial that will inhibit the visible growth of a microorganism after overnight incubation. antibiotic_resistance ARO:3004370 minimum inhibitory concentration (MIC) ARO:3004370 Minimum inhibitory concentration (MIC), in microbiology, is the lowest concentration of an antimicrobial that will inhibit the visible growth of a microorganism after overnight incubation. PMID:19626213 The measured or quantified MIC. antibiotic_resistance ARO:3004371 MIC value ARO:3004371 The measured or quantified MIC. PMID:19626213 Unit for measurement of minimum inhibitory concentration (MIC). antibiotic_resistance ARO:3004372 MIC unit ARO:3004372 Unit for measurement of minimum inhibitory concentration (MIC). PMID:19626213 A calcium-dependent cyclic lipopeptide found to be effective against multidrug-resistant Staphylococcus aureus in cutaneous wound infections. ChEBI:140173 PubChem:132274667 antibiotic_resistance ARO:3004374 malacidin A ARO:3004374 A calcium-dependent cyclic lipopeptide found to be effective against multidrug-resistant Staphylococcus aureus in cutaneous wound infections. PMID:29434326 Biosynthesis of malacidin A and malacidin B calcium-dependent cyclic lipopeptide antibiotics from uncultured soil bacteria. antibiotic_resistance ARO:3004375 malacidin biosynthesis ARO:3004375 Biosynthesis of malacidin A and malacidin B calcium-dependent cyclic lipopeptide antibiotics from uncultured soil bacteria. PMID:29434326 Biosynthesis of the broad-spectrum Rho transcription factor inhibitor bicyclomycin by hydroxylation of a tRNA-dependent cyclodipeptide synthase core. antibiotic_resistance ARO:3004376 bicyclomycin biosynthesis ARO:3004376 Biosynthesis of the broad-spectrum Rho transcription factor inhibitor bicyclomycin by hydroxylation of a tRNA-dependent cyclodipeptide synthase core. PMID:29053243 A plasmid-mediate quinolone efflux pump described in Klebsiella aerogenes and Escherichia coli. QepA3 confers resistance to fluoroquinolone antibiotics by expelling the antibiotic molecules from the cell. This is distinct from the usual chromosomal mutation mechanism of quinolone resistance. Described by Wang et al. 2017. QepA3 antibiotic_resistance ARO:3004378 QepA3 ARO:3004378 A plasmid-mediate quinolone efflux pump described in Klebsiella aerogenes and Escherichia coli. QepA3 confers resistance to fluoroquinolone antibiotics by expelling the antibiotic molecules from the cell. This is distinct from the usual chromosomal mutation mechanism of quinolone resistance. Described by Wang et al. 2017. PMID:26947590 QepA3 A plasmid-mediated quinolone efflux pump variant described in Escherichia coli. QepA4 confers resistance to quinolone and fluoroquinolone antibiotics by expulsion from the cell. Described by Manageiro et al. 2017. QepA4 antibiotic_resistance ARO:3004379 QepA4 ARO:3004379 A plasmid-mediated quinolone efflux pump variant described in Escherichia coli. QepA4 confers resistance to quinolone and fluoroquinolone antibiotics by expulsion from the cell. Described by Manageiro et al. 2017. PMID:29062302 QepA4 Antibiotic adjuvant and serine beta-lactamase inhibitor, often paired with meropenem for clinical use. ChEMBL:CHEMBL3317857 PubChem:56649692 antibiotic_resistance ARO:3004380 vaborbactam ARO:3004380 Antibiotic adjuvant and serine beta-lactamase inhibitor, often paired with meropenem for clinical use. PMID:29232103 An experimental test conducted inside of a living organism, none of which currently exist for antimicrobial resistance testing. antibiotic_resistance ARO:3004387 in-vivo microbial susceptibility test ARO:3004387 An experimental test conducted outside of a living organism, usually in a tube or plate. antibiotic_resistance ARO:3004388 in-vitro microbial susceptibility test ARO:3004388 Reagents and procedures used during microbial susceptibility testing. antibiotic_resistance ARO:3004389 reagent or protocol used for testing AMR ARO:3004389 System of analysis for determining antimicrobial susceptibility. antibiotic_resistance ARO:3004390 antimicrobial resistance test platform ARO:3004390 Microbial species are inoculated in a growth medium onto which antimicrobial agents are transferred by diffusion. antibiotic_resistance ARO:3004391 diffusion method ARO:3004391 Microbial species are inoculated in a growth medium onto which antimicrobial agents are transferred by diffusion. PMID:29403965 Components of complex mixtures such as plant extracts are separated across a TLC plate and tested for anti-microbial activity. antibiotic_resistance ARO:3004392 thin-layer chromatography (TLC)-bioautography ARO:3004392 Components of complex mixtures such as plant extracts are separated across a TLC plate and tested for anti-microbial activity. PMID:29403965 Allows for time-dependent or concentration-dependent analysis of antimicrobial effects. Several tubes of broth culture medium containing a suspension of the test microbe are treated with varying concentrations of the antimicrobial agent and the percentage of dead cells determined at various time points. time kill curve antibiotic_resistance ARO:3004393 time-kill test ARO:3004393 Allows for time-dependent or concentration-dependent analysis of antimicrobial effects. Several tubes of broth culture medium containing a suspension of the test microbe are treated with varying concentrations of the antimicrobial agent and the percentage of dead cells determined at various time points. PMID:29403965 Relies on the indirect measurement of microbe populations by quantifying microbial ATP production. antibiotic_resistance ARO:3004394 ATP bioluminescence assay ARO:3004394 Relies on the indirect measurement of microbe populations by quantifying microbial ATP production. PMID:29403965 Microbes exposed to antimicrobial agents are then stained with the intercalating agent propidium iodide. Damaged cells emit a positive signal that is detected by flow cytometry analysis. Flow cytometry can also be used to discriminate between dead, damaged and live cells. antibiotic_resistance ARO:3004395 flow cytofluorometric method ARO:3004395 Microbes exposed to antimicrobial agents are then stained with the intercalating agent propidium iodide. Damaged cells emit a positive signal that is detected by flow cytometry analysis. Flow cytometry can also be used to discriminate between dead, damaged and live cells. PMID:29403965 Test that directly detect the presence of a particular resistance mechanism. antibiotic_resistance ARO:3004396 mechanism-specific test ARO:3004396 The microbial species are inoculated in liquid growth medium containing incremental dilutions (usually 2-fold) of the antimicrobial agent. antibiotic_resistance ARO:3004397 broth dilution method ARO:3004397 The microbial species are inoculated in liquid growth medium containing incremental dilutions (usually 2-fold) of the antimicrobial agent. PMID:29403965 Automated system of analysis for determining antimicrobial susceptibility. antibiotic_resistance ARO:3004398 automated testing platform ARO:3004398 Non-automated system of analysis for determining antimicrobial susceptibility. noncommercial testing platform antibiotic_resistance ARO:3004399 manual testing platform ARO:3004399 Specific automated system of analysis for determining antimicrobial susceptibility developed by Omron. antibiotic_resistance ARO:3004400 MicroScan ARO:3004400 Specific automated system of analysis for determining antimicrobial susceptibility developed by Becton Dickinson. antibiotic_resistance ARO:3004401 Phoenix ARO:3004401 Specific automated system of analysis for determining antimicrobial susceptibility developed by Trek, Thermo Fisher Scientific. antibiotic_resistance ARO:3004402 Sensitire ARO:3004402 Specific automated system of analysis for determining antimicrobial susceptibility developed by bioMérieux. antibiotic_resistance ARO:3004403 Vitek System ARO:3004403 Vendor of automated system of analysis for determining antimicrobial susceptibility. antibiotic_resistance ARO:3004404 automated testing platform vendor ARO:3004404 Specific vendor of automated system of analysis for determining antimicrobial susceptibility headquartered in New Jersey, USA. Becton Dickinson is the developer of the Phoenix automated testing platform. antibiotic_resistance ARO:3004405 Becton Dickinson ARO:3004405 Specific vendor of automated system of analysis for determining antimicrobial susceptibility headquartered in France. bioMérieux is the developer of the Vitek automated testing platform. antibiotic_resistance ARO:3004406 bioMérieux ARO:3004406 Specific vendor of automated system of analysis for determining antimicrobial susceptibility headquartered in Berlin and Munich. antibiotic_resistance ARO:3004407 Siemens ARO:3004407 Specific vendor of automated system of analysis for determining antimicrobial susceptibility based in Japan. Omron is the developer of the MicroScan automated testing platform. antibiotic_resistance ARO:3004408 Omron ARO:3004408 Specific vendor of automated system of analysis for determining antimicrobial susceptibility that was acquired by Thermo Fisher Scientific Inc. Thermo Fisher Scienfiic Inc. is headquartered in Massachusetts, USA. Trek is the developer of the Sensitire automated testing platform. Thermo Fisher Scientific antibiotic_resistance ARO:3004409 Trek ARO:3004409 Broth dilution conducted on 96-well microtiter plates (≤200 µL per well). antibiotic_resistance ARO:3004410 micro broth dilution method ARO:3004410 Broth dilution conducted on 96-well microtiter plates (≤200 µL per well). PMID:29403965 This test is a common method of evaluating the antimicrobial activity of plants or microbial extracts. In this method, bacteria are inoculated onto agar plates and the antimicrobial agent is injected into the plate and allowed to diffuse. antibiotic_resistance ARO:3004411 agar well diffusion method ARO:3004411 This test is a common method of evaluating the antimicrobial activity of plants or microbial extracts. In this method, bacteria are inoculated onto agar plates and the antimicrobial agent is injected into the plate and allowed to diffuse. PMID:29403965 This method is commonly used to study the antagonism between microorganisms. The first bacterial strain is inoculated onto agar plates in tight streaks. The bacteria will secrete molecules that diffuse in the agar medium; this medium is cut and placed on another agar plate inoculated with another microorganism. antibiotic_resistance ARO:3004412 agar plug diffusion method ARO:3004412 This method is commonly used to study the antagonism between microorganisms. The first bacterial strain is inoculated onto agar plates in tight streaks. The bacteria will secrete molecules that diffuse in the agar medium; this medium is cut and placed on another agar plate inoculated with another microorganism. PMID:29403965 This method is commonly used to study the antagonism between microorganisms. The microbial strain of interest is seeded by a single streak in the center of the agar plate. After incubation, the plate is seeded with the second microorganism by single streak perpendicular to the central streak. antibiotic_resistance ARO:3004413 cross streak method ARO:3004413 This method is commonly used to study the antagonism between microorganisms. The microbial strain of interest is seeded by a single streak in the center of the agar plate. After incubation, the plate is seeded with the second microorganism by single streak perpendicular to the central streak. PMID:29403965 The antimicrobial agent is transferred from a chromatogram to an agar plate previously inoculated with the test microorganism. antibiotic_resistance ARO:3004414 agar diffusion bioautography ARO:3004414 The antimicrobial agent is transferred from a chromatogram to an agar plate previously inoculated with the test microorganism. PMID:29403965 A developed TLC plate is dipped into or sprayed with a microbial suspension and then incubated. Live microbial cells are visualized using tetrazolium salts. antibiotic_resistance ARO:3004415 direct bioautography ARO:3004415 A developed TLC plate is dipped into or sprayed with a microbial suspension and then incubated. Live microbial cells are visualized using tetrazolium salts. PMID:29403965 The TLC plate is covered with a molten agar medium seeded with the test microbe and the antimicrobial compounds are allowed to diffuse onto the agar medium. Tetrazolium dye staining allows for visualization. agar overlay bioassay antibiotic_resistance ARO:3004416 agar overlay bioautography ARO:3004416 The TLC plate is covered with a molten agar medium seeded with the test microbe and the antimicrobial compounds are allowed to diffuse onto the agar medium. Tetrazolium dye staining allows for visualization. PMID:29403965 Concentration at which bacterial cells in suspension, calculated with respect to final volume (colony forming units/milliliter (cfu/mL)). The standard for broth dilution is 5 x 105cfu/mL. The standard for agar dilution is 104cfu/mL. antibiotic_resistance ARO:3004417 inoculum ARO:3004417 Concentration at which bacterial cells in suspension, calculated with respect to final volume (colony forming units/milliliter (cfu/mL)). The standard for broth dilution is 5 x 105cfu/mL. The standard for agar dilution is 104cfu/mL. PMID:18274517 Medium that supports microorganism growth. antibiotic_resistance ARO:3004418 growth medium ARO:3004418 Assay for beta lactamase detection. antibiotic_resistance ARO:3004419 chromogenic cephalosporinase test ARO:3004419 Assay for beta lactamase detection. PMID:34624 Commercial colorimetric assay for detection of chloramphenicol modifying enzyme chloramphenicol acetyltransferase. antibiotic_resistance ARO:3004420 chloramphenicol acetyltransferase assay (CAT) ARO:3004420 Commercial colorimetric assay for detection of chloramphenicol modifying enzyme chloramphenicol acetyltransferase. PMID:20439409 Greater than 5 x 105 cfu/mL for broth dilution and 104 cfu/mL for agar dilution. antibiotic_resistance ARO:3004421 greater than standard inoculum ARO:3004421 Greater than 5 x 105 cfu/mL for broth dilution and 104 cfu/mL for agar dilution. PMID:18274517 Less than 5 x 105 cfu/mL for broth dilution and 104 cfu/mL for agar dilution. antibiotic_resistance ARO:3004422 less than standard inoculum ARO:3004422 Less than 5 x 105 cfu/mL for broth dilution and 104 cfu/mL for agar dilution. PMID:18274517 Around equal to 5 x 105 cfu/mL for broth dilution and 104 cfu/mL for agar dilution. antibiotic_resistance ARO:3004423 = standard inoculum ARO:3004423 Around equal to 5 x 105 cfu/mL for broth dilution and 104 cfu/mL for agar dilution. PMID:18274517 General purpose medium used for culture of nonfastidious microorganisms. antibiotic_resistance ARO:3004424 Mueller-Hinton Broth ARO:3004424 Incubation atmosphere supplemented with CO2. antibiotic_resistance ARO:3004425 CO2 supplemented medium ARO:3004425 Medium supplementation with 20–25 mg Ca2+ and 10–12.5 mg Mg2+ per liter, which is representative of the divalent cation concentration in blood. Divalent cation supplemented medium is correct to use for susceptibility testing of tetracyclines, daptomycin for gram-positive bacteria and aminoglycosides for Pseudomonas aeruginosarequires. antibiotic_resistance ARO:3004426 divalent cation supplemented medium ARO:3004426 Medium supplementation with 20–25 mg Ca2+ and 10–12.5 mg Mg2+ per liter, which is representative of the divalent cation concentration in blood. Divalent cation supplemented medium is correct to use for susceptibility testing of tetracyclines, daptomycin for gram-positive bacteria and aminoglycosides for Pseudomonas aeruginosarequires. PMID:1551973 Growth medium supplemented with 2% (wt/vol) sodium chloride for testing susceptibility of Staphylococcus aureus to methicillin, oxacillin and nafcillin. antibiotic_resistance ARO:3004427 NaCl supplemented medium ARO:3004427 Growth medium supplemented with 2% (wt/vol) sodium chloride for testing susceptibility of Staphylococcus aureus to methicillin, oxacillin and nafcillin. PMID:12691545 Low thymine and thymidine content. antibiotic_resistance ARO:3004428 Difco Mueller-Hinton Broth ARO:3004428 High thymine and thymidine content. antibiotic_resistance ARO:3004429 BBL Mueller-Hinton Broth ARO:3004429 The tissue type used to select breakpoints from a particular standard, for the interpretation of MIC results. antibiotic_resistance ARO:3004430 antimicrobial resistance tissue specificity ARO:3004430 Qualitative description of a microbial response to antimicrobial agents as described by EUCAST using breakpoints determined through in-vitro testing. These breakpoints are determined irrespective of tissue specificity of infection. antibiotic_resistance ARO:3004431 EUCAST antimicrobial phenotype ARO:3004431 A microbe whose susceptibility to antibiotics is comparable to that of a reference susceptible microbe, meaning that the microbe is sensitive to the particular antibiotic. antibiotic_resistance ARO:3004432 wild-type ARO:3004432 A microbe whose susceptibility to antibiotics differs from that of a reference susceptible microbe, meaning that the microbe is resistant to the particular antibiotic. antibiotic_resistance ARO:3004433 non wild-type ARO:3004433 Vendor of AMR testing equipment and reagents. antibiotic_resistance ARO:3004438 AMR testing vendor ARO:3004438 Details required in reporting antimicrobial resistance. antibiotic_resistance ARO:3004439 component of AMR phenotype measurement ARO:3004439 Qualitative description of a microbial response to antimicrobial agents as described by CLSI using breakpoints that take into consideration tissue specificity of infection. antibiotic_resistance ARO:3004440 CLSI antimicrobial phenotype ARO:3004440 Tet(59) is a chromosome-encoded tetracycline efflux pump described from a Chinese pig manure sample. tet(59) tet59 antibiotic_resistance ARO:3004441 tet(59) ARO:3004441 Tet(59) is a chromosome-encoded tetracycline efflux pump described from a Chinese pig manure sample. PMID:27565618 tet(59) tet(W/N/W) is a mosaic tetracycline resistance gene and ribosomal protection protein. tet(W/N/W) tetWNW antibiotic_resistance ARO:3004442 tet(W/N/W) ARO:3004442 tet(W/N/W) is a mosaic tetracycline resistance gene and ribosomal protection protein. PMID:27565618 tet(W/N/W) A family of class A beta-lactamase enzymes, RSA beta-lactamases show carbapenemase and cephalosporinase activity. antibiotic_resistance ARO:3004443 RSA beta-lactamase ARO:3004443 A family of class A beta-lactamase enzymes, RSA beta-lactamases show carbapenemase and cephalosporinase activity. PMID:29316517 RSA1-1 is a class A beta-lactamase resistance enzyme identified from a functional metagenomic study of contaminated river sediments. RSA1-1 antibiotic_resistance ARO:3004444 RSA1-1 ARO:3004444 RSA1-1 is a class A beta-lactamase resistance enzyme identified from a functional metagenomic study of contaminated river sediments. PMID:29316517 RSA1-1 PBP3 is a penicillin-binding protein and beta-lactam resistance enzyme encoded by the ftsI gene in Haemophilus influenzae. Mutations in ftsI confer resistance to beta-lactam antibiotics. Hinf_PBP3_BLA antibiotic_resistance ARO:3004446 Haemophilus influenzae PBP3 conferring resistance to beta-lactam antibiotics ARO:3004446 PBP3 is a penicillin-binding protein and beta-lactam resistance enzyme encoded by the ftsI gene in Haemophilus influenzae. Mutations in ftsI confer resistance to beta-lactam antibiotics. PMID:29352811 Hinf_PBP3_BLA A class C beta-lactamase endogenous to Aeromonas enteropelogenes (tructi). antibiotic_resistance ARO:3004449 TRU beta-lactamase ARO:3004449 A class C beta-lactamase endogenous to Aeromonas enteropelogenes (tructi). PMID:20124004 A class C beta-lactamase enzyme identified from Aeromonas enteropelogenes. TRU-1 confers resistance to penicillin and cephalosporin antibiotics. TRU-1 antibiotic_resistance ARO:3004450 TRU-1 ARO:3004450 A class C beta-lactamase enzyme identified from Aeromonas enteropelogenes. TRU-1 confers resistance to penicillin and cephalosporin antibiotics. PMID:20124004 TRU-1 A chloramphenicol resistance determinant described in the Gram-negative bacterium Agrobacterium fabrum. Afab_ACT_CHL antibiotic_resistance ARO:3004451 Agrobacterium fabrum chloramphenicol acetyltransferase ARO:3004451 A chloramphenicol resistance determinant described in the Gram-negative bacterium Agrobacterium fabrum. PMID:2013403 Afab_ACT_CHL A chloramphenicol resistance determinant described in Alkalihalobacillus clausii. Acla_ACT_CHL antibiotic_resistance ARO:3004452 Alkalihalobacillus clausii chloramphenicol acetyltransferase ARO:3004452 A chloramphenicol resistance determinant described in Alkalihalobacillus clausii. PMID:19459958 Acla_ACT_CHL A chloramphenicol resistance determinant described in Campylobacter coli. Ccol_ACT_CHL antibiotic_resistance ARO:3004454 Campylobacter coli chloramphenicol acetyltransferase ARO:3004454 A chloramphenicol resistance determinant described in Campylobacter coli. PMID:2227449 Ccol_ACT_CHL A chloramphenicol resistance determinant described in Streptococcus suis. Ssui_ACT_CHL antibiotic_resistance ARO:3004455 Streptococcus suis chloramphenicol acetyltransferase ARO:3004455 A chloramphenicol resistance determinant described in Streptococcus suis. PMID:12726767 Ssui_ACT_CHL A chloramphenicol resistance determinant described in an Enterococcus faecium plasmid. Efac_ACT_CHL antibiotic_resistance ARO:3004456 Enterococcus faecium chloramphenicol acetyltransferase ARO:3004456 A chloramphenicol resistance determinant described in an Enterococcus faecium plasmid. PMID:12603745 Efac_ACT_CHL A chloramphenicol resistance determinant described in Staphylococcus intermedius. Sint_ACT_CHL antibiotic_resistance ARO:3004457 Staphylococcus intermedius chloramphenicol acetyltransferase ARO:3004457 A chloramphenicol resistance determinant described in Staphylococcus intermedius. PMID:1713259 Sint_ACT_CHL A chloramphenicol acetyltransferase and resistance determinant described in Enterococcus faecalis. Efae_ACT_CHL antibiotic_resistance ARO:3004458 Enterococcus faecalis chloramphenicol acetyltransferase ARO:3004458 A chloramphenicol acetyltransferase and resistance determinant described in Enterococcus faecalis. PMID:11735367 Efae_ACT_CHL A chloramphenicol resistance determinant described in a Vibrio anguillarum plasmid sequence. Vang_ACT_CHL antibiotic_resistance ARO:3004460 Vibrio anguillarum chloramphenicol acetyltransferase ARO:3004460 A chloramphenicol resistance determinant described in a Vibrio anguillarum plasmid sequence. PMID:1406372 Vang_ACT_CHL Delafloxacin is a novel fluoroquinolone antibiotic, differentiated from other on-market fluoroquinolones by the absence of a protonatable substituent conferring a weakly acidic character to the molecule. This property results in increased intracellular penetration and enhanced bactericidal activity under acidic conditions. ChEMBL:CHEMBL2105637 PubChem:487101 antibiotic_resistance ARO:3004462 delafloxacin ARO:3004462 Delafloxacin is a novel fluoroquinolone antibiotic, differentiated from other on-market fluoroquinolones by the absence of a protonatable substituent conferring a weakly acidic character to the molecule. This property results in increased intracellular penetration and enhanced bactericidal activity under acidic conditions. PMID:29605887 EBR-2 is a novel EBR-like class B beta-lactamase isolated from an extensively drug-resistant strain of Empedobacter falsenii. EBR-2 antibiotic_resistance ARO:3004463 EBR-2 ARO:3004463 EBR-2 is a novel EBR-like class B beta-lactamase isolated from an extensively drug-resistant strain of Empedobacter falsenii. PMID:29687150 EBR-2 CFE-2 is a plasmid-encoded AmpC beta-lactamase first described from Citrobacter freundii by Chen et al. 2018. CFE-2 antibiotic_resistance ARO:3004464 CFE-2 ARO:3004464 CFE-2 is a plasmid-encoded AmpC beta-lactamase first described from Citrobacter freundii by Chen et al. 2018. PMID:29944954 CFE-2 Chromosomally-encoded phosphoethanolamine (PEtN) transferases shown to confer resistance to polymyxin antibiotics, including colistin. antibiotic_resistance ARO:3004465 intrinsic colistin resistant phosphoethanolamine transferase ARO:3004465 A chromosomally-encoded colistin resistance phosphoethanolamine (PEtN) transferase of Moraxella catarrhalis. ICR-Mc is the protein that represents the closest known ortholog to the colistin resistance MCR-1 and MCR-2 PEtN transferases. ICR-Mc antibiotic_resistance ARO:3004466 ICR-Mc ARO:3004466 A chromosomally-encoded colistin resistance phosphoethanolamine (PEtN) transferase of Moraxella catarrhalis. ICR-Mc is the protein that represents the closest known ortholog to the colistin resistance MCR-1 and MCR-2 PEtN transferases. PMID:29631403 ICR-Mc A class of phosphotransferase enzymes shown to confer resistance to ciprofloxacin by antibiotic inactivation through phosphorylation. The sole example, CrpP, was thought to confer resistance to ciprofloxacin by antibiotic inactivation through phosphorylation, however in the paper by Zubyk & Wright (2021) this was discovered to not be the case. There are no known experimentally validated examples of enzymes with this function. CrpP antibiotic_resistance ARO:3004467 ciprofloxacin phosphotransferase ARO:3004467 A class of phosphotransferase enzymes shown to confer resistance to ciprofloxacin by antibiotic inactivation through phosphorylation. The sole example, CrpP, was thought to confer resistance to ciprofloxacin by antibiotic inactivation through phosphorylation, however in the paper by Zubyk & Wright (2021) this was discovered to not be the case. There are no known experimentally validated examples of enzymes with this function. PMID:29581123 PMID:34001507 A subfamily of the ATP-binding cassette protein superfamily. Unlike other ABC proteins, ABC-F genes are not fused to a transmembrane domain nor associated with transport. It has been shown that ABC-F proteins confer antibiotic resistance via ribosomal protection and not antibiotic efflux as in other ABC proteins. antibiotic_resistance ARO:3004469 ABC-F ATP-binding cassette ribosomal protection protein ARO:3004469 A subfamily of the ATP-binding cassette protein superfamily. Unlike other ABC proteins, ABC-F genes are not fused to a transmembrane domain nor associated with transport. It has been shown that ABC-F proteins confer antibiotic resistance via ribosomal protection and not antibiotic efflux as in other ABC proteins. PMID:27006457 PMID:29376318 PoxtA is an ABC-F subfamily ATP-binding cassette protein that confers resistance to tetracycline, -phenicol, and oxazolidinone via modification of the bacterial ribosome. The encoding gene was isolated from a methicillin-resistant Staphylococcus aureus strain. poxtA antibiotic_resistance ARO:3004470 poxtA ARO:3004470 PoxtA is an ABC-F subfamily ATP-binding cassette protein that confers resistance to tetracycline, -phenicol, and oxazolidinone via modification of the bacterial ribosome. The encoding gene was isolated from a methicillin-resistant Staphylococcus aureus strain. PMID:29635422 poxtA msr-type ABC-F subfamily ribosomal protection proteins expression in Staphylococci species and confer resistance to erythromycin and streptogramin B antibiotics through antibiotic target protection mechanisms. antibiotic_resistance ARO:3004471 msr-type ABC-F protein ARO:3004471 A subgroup of the ABC-F protein subfamily of ATP-binding cassette proteins. lsa-type ABC-F proteins confer resistance to streptogramin, lincosamide and pleuromutilin antibiotics through antibiotic target protection of the ribosome. antibiotic_resistance ARO:3004472 lsa-type ABC-F protein ARO:3004472 A carbapenem antibiotic, administered as the oral drug tebipenem-pivoxil, shown to be effective at treating bacterial infections. ChEMBL:CHEMBL576981 PubChem:9800194 antibiotic_resistance ARO:3004473 tebipenem ARO:3004473 A carbapenem antibiotic, administered as the oral drug tebipenem-pivoxil, shown to be effective at treating bacterial infections. PMID:30014729 A siderophore cephalosporin with antibiotic activity against Gram-negative pathogens including and specifically Pseudomonas aeruginosa. CAS:1225208-94-5 ChEBI:140376 ChEMBL:CHEMBL3989974 PubChem:77843966 antibiotic_resistance ARO:3004474 cefiderocol ARO:3004474 A siderophore cephalosporin with antibiotic activity against Gram-negative pathogens including and specifically Pseudomonas aeruginosa. PMID:29960205 vmlR is an ABC-F ATPase ribosomal protection protein identified in Bacillus subtilus. Shown to confer resistance to lincomycin and streptogramin A virginiamycin. Described by Crowe-McAuliffe et al. 2018. vmlR antibiotic_resistance ARO:3004476 vmlR ARO:3004476 vmlR is an ABC-F ATPase ribosomal protection protein identified in Bacillus subtilus. Shown to confer resistance to lincomycin and streptogramin A virginiamycin. Described by Crowe-McAuliffe et al. 2018. PMID:30126986 PMID:36951104 vmlR Eremomycin pyrrolidide 3, 4, 5, and 6 are semisynthetic glycopeptide derived from vancomycin or eremomycin. There have high activity against staphylococci and enterococci, including vancomycin-resistant strains. antibiotic_resistance ARO:3004477 eremomycin pyrrolidide ARO:3004477 Eremomycin pyrrolidide 3, 4, 5, and 6 are semisynthetic glycopeptide derived from vancomycin or eremomycin. There have high activity against staphylococci and enterococci, including vancomycin-resistant strains. PMID:30237697 Beta-lactamase found in Acinetobacter rudis efficiently inactivating carbapenems and amoxicillin conferring resistance to cephalosporins. OXA-665 antibiotic_resistance ARO:3004478 OXA-665 ARO:3004478 Beta-lactamase found in Acinetobacter rudis efficiently inactivating carbapenems and amoxicillin conferring resistance to cephalosporins. PMID:30247543 OXA-665 Beta-lactamase found in Acinetobacter spp. efficiently inactivating carbapenems and amoxicillin conferring resistance to cephalosporins. OXA-664 antibiotic_resistance ARO:3004479 OXA-664 ARO:3004479 Beta-lactamase found in Acinetobacter spp. efficiently inactivating carbapenems and amoxicillin conferring resistance to cephalosporins. PMID:30247543 OXA-664 Bifidobacterium are antibiotic resistant probiotics are prescribed to upkeep the population beneficial bacteria in the gut microbiome. However, horizontal gene transfer among gut microbes could create harmful antibiotic-resistant pathogenic bacteria, such as Mycobacterium tuberculosis. Lokesh et al. analyzed Bifidobacterium antitubercular drug resistance and mutations in rpoB. They found that B. animalis, B. longum and B. adolescentis showed considerable resistance to pyrazinamide, isoniazid, and streptomycin, while B. adolescentis had mutations both in the rifampicin (RIF) pocket and in regions outside the pockets, and also showed considerable resistance to RIF. Bado_rpoB_RIF antibiotic_resistance ARO:3004480 Bifidobacterium adolescentis rpoB mutants conferring resistance to rifampicin ARO:3004480 Bifidobacterium are antibiotic resistant probiotics are prescribed to upkeep the population beneficial bacteria in the gut microbiome. However, horizontal gene transfer among gut microbes could create harmful antibiotic-resistant pathogenic bacteria, such as Mycobacterium tuberculosis. Lokesh et al. analyzed Bifidobacterium antitubercular drug resistance and mutations in rpoB. They found that B. animalis, B. longum and B. adolescentis showed considerable resistance to pyrazinamide, isoniazid, and streptomycin, while B. adolescentis had mutations both in the rifampicin (RIF) pocket and in regions outside the pockets, and also showed considerable resistance to RIF. PMID:30093677 Bado_rpoB_RIF An OXA-10 family class beta-lactamase identified from a Klebsiella pneumoniae BIDMC 35 isolate. OXA-663 antibiotic_resistance ARO:3004489 OXA-663 ARO:3004489 An OXA-10 family class beta-lactamase identified from a Klebsiella pneumoniae BIDMC 35 isolate. PMID:30126962 OXA-663 A novel nitroimidazole antibiotic for treating Mycobacterium tuberculosis infection. Delamanid inhibits bacterial cell wall growth by mycolic acid synthesis disruption and is particularly effective in combination therapies against multidrug-resistant tuberculosis. CAS:681492-22-8 ChEBI:134742 ChEMBL:CHEMBL218650 PubChem:6480466 deltyba antibiotic_resistance ARO:3004490 delamanid ARO:3004490 A novel nitroimidazole antibiotic for treating Mycobacterium tuberculosis infection. Delamanid inhibits bacterial cell wall growth by mycolic acid synthesis disruption and is particularly effective in combination therapies against multidrug-resistant tuberculosis. PMID:25210407 A class of antibiotics used to treat specifically Mycobacterium tuberculosis infection; therefore, referred to as an antimycobacterial. Diarylquinoline antibiotics inhibit ATP synthesis in tuberculosis cells by disruption of mycobacterial ATP synthase. antibiotic_resistance ARO:3004491 diarylquinoline antibiotic ARO:3004491 A class of antibiotics used to treat specifically Mycobacterium tuberculosis infection; therefore, referred to as an antimycobacterial. Diarylquinoline antibiotics inhibit ATP synthesis in tuberculosis cells by disruption of mycobacterial ATP synthase. PMID:24130398 A diarylquinoline antibiotic drug sold under the brand name Sirturo, used to treat infection from Mycobacterium spp., particularly multidrug-resistant tuberculosis. Bedaquiline disrupts ATP synthase by proton pump blockage, inhibiting ATP synthesis. CAS:843663-66-1 ChEBI:72292 ChEMBL:CHEMBL376488 PubChem:5388906 Sirturo antibiotic_resistance ARO:3004492 bedaquiline ARO:3004492 A diarylquinoline antibiotic drug sold under the brand name Sirturo, used to treat infection from Mycobacterium spp., particularly multidrug-resistant tuberculosis. Bedaquiline disrupts ATP synthase by proton pump blockage, inhibiting ATP synthesis. PMID:24130398 A class C carbapenemase and extended-spectrum beta-lactamase identified from Acinetobacter baumannii. ADC-68 antibiotic_resistance ARO:3004493 ADC-68 ARO:3004493 A class C carbapenemase and extended-spectrum beta-lactamase identified from Acinetobacter baumannii. PMID:25372683 ADC-68 An IMP class B metallo-beta-lactamase enzyme identified from Acinetobacter baumannii. IMP-55 antibiotic_resistance ARO:3004494 IMP-55 ARO:3004494 An IMP class B metallo-beta-lactamase enzyme identified from Acinetobacter baumannii. PMID:28336429 IMP-55 An IMP class B metallo-beta-lactamase enzyme identified from carbapenem-resistant Pseudomonas aeruginosa. IMP-56 antibiotic_resistance ARO:3004495 IMP-56 ARO:3004495 IMP-56 A KPC class A beta-lactamase and carbapenemase identified from Chilean isolates of Klebsiella pneumoniae. KPC-24 antibiotic_resistance ARO:3004496 KPC-24 ARO:3004496 A KPC class A beta-lactamase and carbapenemase identified from Chilean isolates of Klebsiella pneumoniae. PMID:27436389 KPC-24 A trimethoprim-resistant dihydrofolate reductase characterized on a class I integron from an E. coli isolate. dfrA2d dfrB4 antibiotic_resistance ARO:3004498 dfrB4 ARO:3004498 A trimethoprim-resistant dihydrofolate reductase characterized on a class I integron from an E. coli isolate. PMID:28242670 dfrB4 Tosufloxacin is a fluoroquinolone antibiotic with an extended spectrum of activity. CAS:100490-36-6 ChEBI:77573 ChEMBL:CHEMBL273348 PubChem:5517 antibiotic_resistance ARO:3004499 Tosufloxacin ARO:3004499 Tosufloxacin is a fluoroquinolone antibiotic with an extended spectrum of activity. PMID:1906696 An MCR-3 phosphoethanolamine transferase and polymyxin resistance gene variant differing by 2 amino acid substitutions, identified from an Escherichia coli isolate. MCR-3.11 antibiotic_resistance ARO:3004500 MCR-3.11 ARO:3004500 An MCR-3 phosphoethanolamine transferase and polymyxin resistance gene variant differing by 2 amino acid substitutions, identified from an Escherichia coli isolate. PMID:29760138 MCR-3.11 An MCR-2 phosphoethanolamine transferase and polymyxin resistance gene variant identified in Moraxella isolated from pigs in the United Kingdom. MCR-6.1 antibiotic_resistance ARO:3004501 MCR-6.1 ARO:3004501 An MCR-2 phosphoethanolamine transferase and polymyxin resistance gene variant identified in Moraxella isolated from pigs in the United Kingdom. PMID:30053008 MCR-6.1 An MCR-2 phosphoethanolamine transferase and polymyxin resistance gene variant identified in Moraxella isolated from pigs in Great Britain. MCR-2.2 antibiotic_resistance ARO:3004502 MCR-2.2 ARO:3004502 An MCR-2 phosphoethanolamine transferase and polymyxin resistance gene variant identified in Moraxella isolated from pigs in Great Britain. PMID:29091193 PMID:29091227 MCR-2.2 An MCR-3 phosphoethanolamine transferase and polymyxin resistance gene variant identified in Aeromonas. MCR-3.6 antibiotic_resistance ARO:3004503 MCR-3.6 ARO:3004503 An MCR-3 phosphoethanolamine transferase and polymyxin resistance gene variant identified in Aeromonas. PMID:29394397 MCR-3.6 An MCR-3 phosphoethanolamine transferase and polymyxin (colistin) resistance gene variant identified from Aeromonas, Proteus and Escherichia coli. MCR-3.10 antibiotic_resistance ARO:3004504 MCR-3.10 ARO:3004504 An MCR-3 phosphoethanolamine transferase and polymyxin (colistin) resistance gene variant identified from Aeromonas, Proteus and Escherichia coli. PMID:29203482 MCR-3.10 An MCR-3 phosphoethanolamine transferase and polymyxin (colistin) resistance gene variant identified from an extensively-resistant Escherichia coli clinical isolate. MCR-3.5 antibiotic_resistance ARO:3004505 MCR-3.5 ARO:3004505 An MCR-3 phosphoethanolamine transferase and polymyxin (colistin) resistance gene variant identified from an extensively-resistant Escherichia coli clinical isolate. PMID:28971871 PMID:30053115 MCR-3.5 An MCR-1 phosphoethanolamine transferase and polymyxin (colistin) resistance gene variant identified from an Escherichia porcine isolate in Great Britain. MCR-1.10 antibiotic_resistance ARO:3004506 MCR-1.10 ARO:3004506 An MCR-1 phosphoethanolamine transferase and polymyxin (colistin) resistance gene variant identified from an Escherichia porcine isolate in Great Britain. PMID:29091227 MCR-1.10 An MCR-1 phosphoethanolamine transferase and polymyxin resistance gene variant identified from an enterotoxigenic Escherichia coli clinical isolate. MCR-1.9 antibiotic_resistance ARO:3004507 MCR-1.9 ARO:3004507 An MCR-1 phosphoethanolamine transferase and polymyxin resistance gene variant identified from an enterotoxigenic Escherichia coli clinical isolate. PMID:29922243 MCR-1.9 An MCR-3 polymyxin (incl. colistin) resistance gene variant isolated from an Aeromonas isolate. MCR-3.9 antibiotic_resistance ARO:3004508 MCR-3.9 ARO:3004508 An MCR-3 polymyxin (incl. colistin) resistance gene variant isolated from an Aeromonas isolate. PMID:29394397 MCR-3.9 An MCR-3 polymyxin (incl. colistin) resistance gene variant identified from an Aeromonas isolate. MCR-3.8 antibiotic_resistance ARO:3004509 MCR-3.8 ARO:3004509 An MCR-3 polymyxin (incl. colistin) resistance gene variant identified from an Aeromonas isolate. PMID:29394397 MCR-3.8 An MCR polymyxin (colistin) resistance gene variant identified in Aeromonas. MCR-3.7 antibiotic_resistance ARO:3004510 MCR-3.7 ARO:3004510 An MCR polymyxin (colistin) resistance gene variant identified in Aeromonas. PMID:29394397 MCR-3.7 An MCR-3 polymyxin resistance gene variant identified in a colistin-resistant Salmonella isolate from Canada, located on an IncHI-2 plasmid. MCR-3.2 antibiotic_resistance ARO:3004511 MCR-3.2 ARO:3004511 An MCR-3 polymyxin resistance gene variant identified in a colistin-resistant Salmonella isolate from Canada, located on an IncHI-2 plasmid. PMID:30351266 MCR-3.2 An MCR-1 polymyxin resistance gene variant identified from colistin-resistant Salmonella enterica (serovar typhimurium) isolate, carried by an IncP plasmid. MCR-1.6 antibiotic_resistance ARO:3004513 MCR-1.6 ARO:3004513 An MCR-1 polymyxin resistance gene variant identified from colistin-resistant Salmonella enterica (serovar typhimurium) isolate, carried by an IncP plasmid. PMID:28264851 MCR-1.6 An MCR-1 polymyxin resistance gene variant identified from a poultry Raoultella planticola isolate. MCR-1.3 antibiotic_resistance ARO:3004514 MCR-1.3 ARO:3004514 An MCR-1 polymyxin resistance gene variant identified from a poultry Raoultella planticola isolate. PMID:28242671 PMID:29778190 MCR-1.3 An MCR-1 polymyxin resistance gene variant identified from a colistin-resistant Escherichia coli isolate. MCR-1.4 antibiotic_resistance ARO:3004515 MCR-1.4 ARO:3004515 An MCR-1 polymyxin resistance gene variant identified from a colistin-resistant Escherichia coli isolate. PMID:29118748 MCR-1.4 A novel phosphoethanolamine transferase and mobile colistin resistance gene identified from carbapenem-resistant NDM-1-producing Klebsiella pneumoniae. MCR-8.1 antibiotic_resistance ARO:3004516 MCR-8.1 ARO:3004516 A novel phosphoethanolamine transferase and mobile colistin resistance gene identified from carbapenem-resistant NDM-1-producing Klebsiella pneumoniae. PMID:29970891 MCR-8.1 A novel plasmid-mediated colistin-resistant phosphoethanolamine transferase identified from a poultry isolate of Klebsiella pneumoniae. MCR-7.1 antibiotic_resistance ARO:3004517 MCR-7.1 ARO:3004517 A novel plasmid-mediated colistin-resistant phosphoethanolamine transferase identified from a poultry isolate of Klebsiella pneumoniae. PMID:29912417 MCR-7.1 MIC sign (>, <, =) of the MIC value. antibiotic_resistance ARO:3004519 MIC sign ARO:3004519 Greater than MIC value. antibiotic_resistance ARO:3004520 > ARO:3004520 Less than MIC value. antibiotic_resistance ARO:3004521 < ARO:3004521 Equal to MIC value. antibiotic_resistance ARO:3004522 = ARO:3004522 MIC is a range of two MIC values (e.g., given 10 clinical isolates with a resistance determinant, there are 5 that have an MIC of 25ug/mL and 5 that have an MIC of 100ug/mL agaisnt tobramycin). antibiotic_resistance ARO:3004523 MIC range ARO:3004523 Strain type used for antibiotic susceptibility testing. antibiotic_resistance ARO:3004524 strain type ARO:3004524 Resistant determinant is identified in strain without any experimental methods. antibiotic_resistance ARO:3004525 resistance determinant in strain ARO:3004525 Experimental deletion of resistance determinant in the chromosome of the strain initially with this resistance determinant. antibiotic_resistance ARO:3004526 deletion of resistance determinant ARO:3004526 Experimental protocol where there is a deletion of resistance determinant and the transformation of a plasmid harbouring resistance determinant into the same strain. antibiotic_resistance ARO:3004527 deletion of resistance determinant with plasmid harbouring resistance determinant ARO:3004527 Experimental procedure where plasmid harbouring a resistance determinant is transformed into a strain. antibiotic_resistance ARO:3004528 plasmid harbouring resistance determinant ARO:3004528 Without any experimental protocol, the resistance determinant is absent from the strain. antibiotic_resistance ARO:3004529 resistance determinant not in strain ARO:3004529 Experimental insertion of resistance determinant in the chromosome of the strain initially without this resistance determinant. antibiotic_resistance ARO:3004530 insertion of resistance determinant ARO:3004530 Specific strain of bacteria that was used to perform the antibiotic susceptibility test. antibiotic_resistance ARO:3004531 strain ARO:3004531 Source of the strain used in the antibiotic susceptibility test (e.g., clinical, environmental, agriculture). antibiotic_resistance ARO:3004532 strain source ARO:3004532 Strain isolated in a clinical setting (e.g., from a patient). antibiotic_resistance ARO:3004533 clinical source ARO:3004533 Strain collected from environment (e.g., soil, water). antibiotic_resistance ARO:3004534 environmental source ARO:3004534 Strain collected from agricultural setting (e.g., chicken, pig). antibiotic_resistance ARO:3004535 agricultural source ARO:3004535 The control of the antibiotic susceptibility testing, whether there was an experimental control (same strain, with and without resistance determinant) or if there was a group of clinical isolates found to have a resistance determinant compared against a strain without that resistance determinant. antibiotic_resistance ARO:3004536 antimicrobial susceptibility test control ARO:3004536 Antimicrobial susceptibility testing was performed on the same strain with and without a resistance determinant. antibiotic_resistance ARO:3004537 experimental control ARO:3004537 Antibiotic susceptibility testing is performed on a group of clinical isolates with a resistance determinant compared to different strains that do not have this resistance determinant. No experiment was performed to delete / insert the resistance determinant to determine antibiotic susceptibility using the same genetic background. antibiotic_resistance ARO:3004538 correlative control ARO:3004538 A chromosomal macrolide 2'-phosphotransferase and resistance gene identified from a Brachybacterium faecium cave isolate. mphH antibiotic_resistance ARO:3004539 mphH ARO:3004539 A chromosomal macrolide 2'-phosphotransferase and resistance gene identified from a Brachybacterium faecium cave isolate. PMID:22509370 PMID:29317655 mphH Source is an experimental, commonly used lab strain (e.g., P. aeruginosa PAO1). antibiotic_resistance ARO:3004540 experimental source ARO:3004540 A chromosomal macrolide phosphotransferase identified from Bacillus subtilis. mphK antibiotic_resistance ARO:3004541 mphK ARO:3004541 A chromosomal macrolide phosphotransferase identified from Bacillus subtilis. PMID:29317655 mphK A macrolide phosphotransferase identified on a plasmid in Exiguobacterium. mphN antibiotic_resistance ARO:3004542 mphN ARO:3004542 A macrolide phosphotransferase identified on a plasmid in Exiguobacterium. PMID:24362420 PMID:29317655 mphN A chromosomal macrolide phosphostransferase identified in Brachybacterium paraconglomeratum. mphO antibiotic_resistance ARO:3004543 mphO ARO:3004543 A chromosomal macrolide phosphostransferase identified in Brachybacterium paraconglomeratum. PMID:22509370 PMID:29317655 mphO A chromosomal macrolide phosphotransferase identified in Brevibacillus brevis VM4. mphJ antibiotic_resistance ARO:3004544 mphJ ARO:3004544 A chromosomal macrolide phosphotransferase identified in Brevibacillus brevis VM4. PMID:29259290 PMID:29317655 mphJ ADC beta-lactamase enzymes with demonstrable carbapenemase activity, an exception amongst these enzymes. antibiotic_resistance ARO:3004545 ADC beta-lactamase with carbapenemase activity ARO:3004545 ADC beta-lactamase enzymes with demonstrable carbapenemase activity, an exception amongst these enzymes. PMID:25372683 Point mutations in the 23S ribosomal RNA domain of Campylobacter jejuni which confer resistance to macrolide antibiotics, including erythromycin. Cjej_23S_ERY antibiotic_resistance ARO:3004546 Campylobacter jejuni 23S rRNA with mutation conferring resistance to erythromycin ARO:3004546 Point mutations in the 23S ribosomal RNA domain of Campylobacter jejuni which confer resistance to macrolide antibiotics, including erythromycin. PMID:12604552 Cjej_23S_ERY A dihydrofolate reductase and antibiotic resistance gene identified from an integron in Vibrio cholerae. dfr6 dfrA6 antibiotic_resistance ARO:3004547 dfrA6 ARO:3004547 A dihydrofolate reductase and antibiotic resistance gene identified from an integron in Vibrio cholerae. PMID:19704128 dfrA6 A dihydrofolate reductase and trimethoprim resistance gene identified from porcine isolates of Esherichia coli. dfr9 dfrA9 dfrIX antibiotic_resistance ARO:3004548 dfrA9 ARO:3004548 A dihydrofolate reductase and trimethoprim resistance gene identified from porcine isolates of Esherichia coli. PMID:1659308 dfrA9 A dihydrofolate reductase and trimethoprim resistance gene identified from an integron in Pseudomonas aeruginosa. dfr-lie dfrB5 antibiotic_resistance ARO:3004549 dfrB5 ARO:3004549 A dihydrofolate reductase and trimethoprim resistance gene identified from an integron in Pseudomonas aeruginosa. PMID:16048978 dfrB5 A dihydrofolate reductase and trimethoprim resistance gene from non-O1, non-O139 Vibrio cholerae. dfrA27 antibiotic_resistance ARO:3004550 dfrA27 ARO:3004550 A dihydrofolate reductase and trimethoprim resistance gene from non-O1, non-O139 Vibrio cholerae. PMID:25870070 dfrA27 A dihydrofolate reductase and trimethoprim resistance gene from Aeromonas hydrophilia. dfrA28 antibiotic_resistance ARO:3004551 dfrA28 ARO:3004551 A dihydrofolate reductase and trimethoprim resistance gene from Aeromonas hydrophilia. PMID:21764945 dfrA28 A dihydrofolate reductase and trimethoprim resistance gene from Klebsiella pneumoniae. dfrA30 antibiotic_resistance ARO:3004552 dfrA30 ARO:3004552 A dihydrofolate reductase and trimethoprim resistance gene from Klebsiella pneumoniae. PMID:21595893 dfrA30 A dihydrofolate reductase and trimethoprim resistance gene isolated from canine Escherichia coli infection. dfrA29 antibiotic_resistance ARO:3004554 dfrA29 ARO:3004554 A dihydrofolate reductase and trimethoprim resistance gene isolated from canine Escherichia coli infection. PMID:27302904 dfrA29 A dihydrofolate reductase and trimethoprim resistance gene identified from non-typhoidal multidrug-resistant Salmonella enterica. dfrA32 antibiotic_resistance ARO:3004555 dfrA32 ARO:3004555 A dihydrofolate reductase and trimethoprim resistance gene identified from non-typhoidal multidrug-resistant Salmonella enterica. PMID:19921331 dfrA32 A dihydrofolate reductase and trimethoprim resistance gene identified on an integron in multidrug-resistant gram-negative bacteria. dfrB7 dfrB8 antibiotic_resistance ARO:3004556 dfrB7 ARO:3004556 A dihydrofolate reductase and trimethoprim resistance gene identified on an integron in multidrug-resistant gram-negative bacteria. PMID:21627486 dfrB7 CAM (Central Alberta Metallo) beta-lactamases are class B metallo-beta-lactamases and carbapenemases found to confer resistance to broad spectrum antibiotics in Pseudomonas aeruginosa. antibiotic_resistance ARO:3004558 CAM beta-lactamase ARO:3004558 CAM (Central Alberta Metallo) beta-lactamases are class B metallo-beta-lactamases and carbapenemases found to confer resistance to broad spectrum antibiotics in Pseudomonas aeruginosa. PMID:30789204 CAM-1 is a CAM (Central Alberta Metallo) beta-lactamase and carbapenemase identified from 4 clinical isolates of Pseudomonas aeruginosa from a Canadian hospital. CAM-1 antibiotic_resistance ARO:3004559 CAM-1 ARO:3004559 CAM-1 is a CAM (Central Alberta Metallo) beta-lactamase and carbapenemase identified from 4 clinical isolates of Pseudomonas aeruginosa from a Canadian hospital. PMID:30789204 CAM-1 murG acetylglucosaminyltransferase enzymes inhibited by vancomycin. Mutations in murG confer resistance to vancomycin through antibiotic target alteration. antibiotic_resistance ARO:3004560 murG transferase ARO:3004560 murG acetylglucosaminyltransferase enzymes inhibited by vancomycin. Mutations in murG confer resistance to vancomycin through antibiotic target alteration. PMID:23887866 Mutations in murG which confer resistance to vancomycin in Clostridioides difficile. Cdif_murG_VAN antibiotic_resistance ARO:3004561 Clostridioides difficile murG with mutation conferring resistance to vancomycin ARO:3004561 Mutations in murG which confer resistance to vancomycin in Clostridioides difficile. PMID:23887866 Cdif_murG_VAN Point mutations in gyrB of Clostridioides difficile conferring resistance to fluoroquinolone antibiotics. Cdif_gyrB_FLO antibiotic_resistance ARO:3004562 Clostridioides difficile gyrB conferring resistance to fluoroquinolones ARO:3004562 Point mutations in gyrB of Clostridioides difficile conferring resistance to fluoroquinolone antibiotics. PMID:12384345 PMID:18480338 PMID:20226332 PMID:22508299 PMID:27842877 Cdif_gyrB_FLO Point mutations in the rpoB region of Clostridioides difficile which confer resistance to rifampin and rifampicin antibiotics. Cdif_rpoB_RIF antibiotic_resistance ARO:3004563 Clostridioides difficile rpoB with mutation conferring resistance to rifampicin ARO:3004563 Point mutations in the rpoB region of Clostridioides difficile which confer resistance to rifampin and rifampicin antibiotics. PMID:18559647 PMID:19140738 PMID:21998414 PMID:22361457 PMID:22908175 PMID:23887866 PMID:29383668 Cdif_rpoB_RIF Resistance-modifying agent (RMA) without characterized mechanism which do not exhibit antibiotic activity on their own, but improve the performance of antibiotic drugs. antibiotic_resistance ARO:3004564 unclassified resistance-modifying agents ARO:3004564 Resistance-modifying agent (RMA) without characterized mechanism which do not exhibit antibiotic activity on their own, but improve the performance of antibiotic drugs. PMID:27657810 PMID:29264917 A class of resistance-modifying agents and beta-lactam potentiators which selectively potentiate beta-lactam antibiotics, specifically Amoxicillin-clavulanic acid, in methicillin-resistant Staphylococcus aureus (MRSA) without their own antimicrobial activity. antibiotic_resistance ARO:3004565 tetracyclic indoline ARO:3004565 A class of resistance-modifying agents and beta-lactam potentiators which selectively potentiate beta-lactam antibiotics, specifically Amoxicillin-clavulanic acid, in methicillin-resistant Staphylococcus aureus (MRSA) without their own antimicrobial activity. PMID:27657810 Rifalazil is a rifamycin derivative antibiotic, sometimes used for treating Clostridioides difficile infections. ChEBI:188526 ChEMBL:CHEMBL236297 PubChem:135431094 antibiotic_resistance ARO:3004566 Rifalazil ARO:3004566 Rifalazil is a rifamycin derivative antibiotic, sometimes used for treating Clostridioides difficile infections. PMID:12556219 Ramoplanin is a glycolipodepsipeptide antibiotic derived from gram-positive Actinoplanes used to treat infection with Clostridioides difficile. ChEBI:29670 ChEMBL:CHEMBL2368737 PubChem:16132338 antibiotic_resistance ARO:3004567 Ramoplanin ARO:3004567 Ramoplanin is a glycolipodepsipeptide antibiotic derived from gram-positive Actinoplanes used to treat infection with Clostridioides difficile. PMID:25182650 A trimethoprim-resistant dihydrofolate reductase identified from Vibrio cholerae. dfr18 dfrA18 antibiotic_resistance ARO:3004568 dfrA18 ARO:3004568 A trimethoprim-resistant dihydrofolate reductase identified from Vibrio cholerae. PMID:11600347 dfrA18 A chromosomally-encoded colistin resistance phosphoethanolamine (PEtN) transferase of Moraxella osloensis. ICR-Mo represents the closest known ortholog to the colistin resistance MCR-1 and MCR-2 PEtN transferases. ICR-Mo antibiotic_resistance ARO:3004569 ICR-Mo ARO:3004569 A chromosomally-encoded colistin resistance phosphoethanolamine (PEtN) transferase of Moraxella osloensis. ICR-Mo represents the closest known ortholog to the colistin resistance MCR-1 and MCR-2 PEtN transferases. PMID:29758020 ICR-Mo PNGM is a family of metallo-beta-lactamases first identified from a deep-sea sediment metagenome and shown to reduce antibiotic susceptibility by hydrolysis of penicillins, carbapenems and extended- and broad-spectrum cephalosporins. antibiotic_resistance ARO:3004570 PNGM beta-lactamase ARO:3004570 PNGM is a family of metallo-beta-lactamases first identified from a deep-sea sediment metagenome and shown to reduce antibiotic susceptibility by hydrolysis of penicillins, carbapenems and extended- and broad-spectrum cephalosporins. PMID:29842976 PNGM-1 is a subclass B3 metallo-beta-lactamase first identified from a deep-sea sediment meta-genome. PNGM-1 is shown to reduce susceptibility to extended- and broad-spectrum cephalosporins, carbapenems, and penicillins. PNGM-1 is a novel metallo-beta-lactamase which predates the current antibiotic era. PNGM-1 antibiotic_resistance ARO:3004571 PNGM-1 ARO:3004571 PNGM-1 is a subclass B3 metallo-beta-lactamase first identified from a deep-sea sediment meta-genome. PNGM-1 is shown to reduce susceptibility to extended- and broad-spectrum cephalosporins, carbapenems, and penicillins. PNGM-1 is a novel metallo-beta-lactamase which predates the current antibiotic era. PMID:29842976 PNGM-1 MFS transporters are secondary active transporters with single-polypeptide chains containing 400-600 amino acids that transport small solutes across the membrane by using electrochemical gradients. LmrS has 14 transmembrane helices and, when expressed in E. coli, is capable of extruding a variety of antibiotics inclinding linezolid, trimethoprim, florfenicol, chlorampheniocol, erythromycin, streptomycin, kanamycin, and fusidic acid. A0A3M7YRP9 A0A3P0BBR7 F6MF49 Saur_LmrS antibiotic_resistance ARO:3004572 Staphylococcus aureus LmrS ARO:3004572 MFS transporters are secondary active transporters with single-polypeptide chains containing 400-600 amino acids that transport small solutes across the membrane by using electrochemical gradients. LmrS has 14 transmembrane helices and, when expressed in E. coli, is capable of extruding a variety of antibiotics inclinding linezolid, trimethoprim, florfenicol, chlorampheniocol, erythromycin, streptomycin, kanamycin, and fusidic acid. PMID:20855745 Saur_LmrS Expression of abaF in E. coli resulted in increased resistance to fosfomycin. Abau_AbaF P0DPR5 antibiotic_resistance ARO:3004573 Acinetobacter baumannii AbaF ARO:3004573 Expression of abaF in E. coli resulted in increased resistance to fosfomycin. PMID:27650185 Abau_AbaF AbaQ is an MFS transporter mainly involved in the extrusion of quinolone-type drugs in A. baumannii. Abau_AbaQ P0DPR4 antibiotic_resistance ARO:3004574 Acinetobacter baumannii AbaQ ARO:3004574 AbaQ is an MFS transporter mainly involved in the extrusion of quinolone-type drugs in A. baumannii. PMID:29941648 Abau_AbaQ Members of the radical SAM superfamily are involved in a wide variety of reactions, including unusual methylations, isomerization, sulfur insertion, ring formation, anaerobic oxidation, and protein radical formation. antibiotic_resistance ARO:3004575 S-adenosylmethionine (SAM) superfamily ARO:3004575 A tetracycline-resistance ribosomal protection protein. tet(61) antibiotic_resistance ARO:3004576 tet(61) ARO:3004576 A tetracycline-resistance ribosomal protection protein. PMID:33866063 tet(61) AmvA has 14 alpha-helical transmembrane segments, qualifying it as a member of the DHA2 transporter family of the major facilitator superfamily (MFS). When AmvA was expressed in E. coli, the cells had at least four-fold decreased susceptibility to erythromycin, acridine orange, acriflavine, deoxycholate and methyl viologen. AmvA from the AC0037 strain of A. baumannii was tested. Abau_AmvA B0V737 antibiotic_resistance ARO:3004577 Acinetobacter baumannii AmvA ARO:3004577 AmvA has 14 alpha-helical transmembrane segments, qualifying it as a member of the DHA2 transporter family of the major facilitator superfamily (MFS). When AmvA was expressed in E. coli, the cells had at least four-fold decreased susceptibility to erythromycin, acridine orange, acriflavine, deoxycholate and methyl viologen. AmvA from the AC0037 strain of A. baumannii was tested. PMID:20573661 Abau_AmvA AbuO is akin to the TolC outer membrane efflux protein. Deletion in A. baumannii results in increased susceptibility to antibiotics including amikacin, carbenicillin, ceftriaxone, meropenem, streptomycin, and tigecycline as well as disinfectants benzyalkonium chloride and chlorhexidine. A0A225SC95 Abau_AbuO Q2FD57 antibiotic_resistance ARO:3004578 Acinetobacter baumannii AbuO ARO:3004578 AbuO is akin to the TolC outer membrane efflux protein. Deletion in A. baumannii results in increased susceptibility to antibiotics including amikacin, carbenicillin, ceftriaxone, meropenem, streptomycin, and tigecycline as well as disinfectants benzyalkonium chloride and chlorhexidine. PMID:25512405 Abau_AbuO KpnE subunit of KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan. A6T8S5 Kpne_KpnE antibiotic_resistance ARO:3004580 Klebsiella pneumoniae KpnE ARO:3004580 KpnE subunit of KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan. PMID:23836167 Kpne_KpnE A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. tet(48) antibiotic_resistance ARO:3004581 tet(48) ARO:3004581 A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. PMID:26097034 tet(48) A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. tet(49) antibiotic_resistance ARO:3004582 tet(49) ARO:3004582 A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. PMID:26097034 tet(49) KpnF subunit of KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan. A6T8S6 Kpne_KpnF antibiotic_resistance ARO:3004583 Klebsiella pneumoniae KpnF ARO:3004583 KpnF subunit of KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan. PMID:23836167 Kpne_KpnF A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. tet(50) antibiotic_resistance ARO:3004584 tet(50) ARO:3004584 A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. PMID:26097034 tet(50) KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan. antibiotic_resistance ARO:3004585 Klebsiella pneumoniae KpnEF ARO:3004585 KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan. PMID:23836167 A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. tet(51) antibiotic_resistance ARO:3004586 tet(51) ARO:3004586 A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. PMID:26097034 tet(51) A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. tet(52) antibiotic_resistance ARO:3004587 tet(52) ARO:3004587 A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. PMID:26097034 tet(52) KpnG consists of ~390 residues and resembles EmrA of E. coli. Disruption of the pump components KpnG-KpnH signficantly decrease resistance to azithromycin, ceftazidime, ciprofloxacin, ertapenem, erythromycin, gentamicin, imipenem, ticarcillin, norfloxacin, polymyxin-B, piperacillin, spectinomycin, tobramycin, and streptomycin. C8T8U1 Kpne_KpnG antibiotic_resistance ARO:3004588 Klebsiella pneumoniae KpnG ARO:3004588 KpnG consists of ~390 residues and resembles EmrA of E. coli. Disruption of the pump components KpnG-KpnH signficantly decrease resistance to azithromycin, ceftazidime, ciprofloxacin, ertapenem, erythromycin, gentamicin, imipenem, ticarcillin, norfloxacin, polymyxin-B, piperacillin, spectinomycin, tobramycin, and streptomycin. PMID:24823362 Kpne_KpnG A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. tet(53) antibiotic_resistance ARO:3004589 tet(53) ARO:3004589 A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. PMID:26097034 tet(53) A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. tet(54) antibiotic_resistance ARO:3004590 tet(54) ARO:3004590 A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. PMID:26097034 tet(54) A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. tet(55) antibiotic_resistance ARO:3004591 tet(55) ARO:3004591 A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. PMID:26097034 tet(55) erm(32) is a rRNA methyltransferase. Encodes methyltransferases that modify 23S rRNA. erm(32) antibiotic_resistance ARO:3004592 erm(32) ARO:3004592 erm(32) is a rRNA methyltransferase. Encodes methyltransferases that modify 23S rRNA. PMID:10348045 erm(32) Erm45 is an rRNA methylase that confers resistances to macrolide, lincosamide, and streptogramin B. erm(45) antibiotic_resistance ARO:3004595 erm(45) ARO:3004595 Erm45 is an rRNA methylase that confers resistances to macrolide, lincosamide, and streptogramin B. PMID:25779586 erm(45) erm(46) is transferable determinant that confers resistance to macrolides. ErmREQ erm(46) antibiotic_resistance ARO:3004596 erm(46) ARO:3004596 erm(46) is transferable determinant that confers resistance to macrolides. PMID:26377866 erm(46) KpnH consists of ~511 residues, resembles EmrB of E. coli, and is probably a translocase in the KpnGH-TolC efflux protein in K. pneumoniae. Disruption of the pump components KpnG-KpnH signficantly decrease resistance to azithromycin, ceftazidime, ciprofloxacin, ertapenem, erythromycin, gentamicin, imipenem, ticarcillin, norfloxacin, polymyxin-B, piperacillin, spectinomycin, tobramycin, and streptomycin. A0A3F3BH25 Kpne_KpnH antibiotic_resistance ARO:3004597 Klebsiella pneumoniae KpnH ARO:3004597 KpnH consists of ~511 residues, resembles EmrB of E. coli, and is probably a translocase in the KpnGH-TolC efflux protein in K. pneumoniae. Disruption of the pump components KpnG-KpnH signficantly decrease resistance to azithromycin, ceftazidime, ciprofloxacin, ertapenem, erythromycin, gentamicin, imipenem, ticarcillin, norfloxacin, polymyxin-B, piperacillin, spectinomycin, tobramycin, and streptomycin. PMID:24823362 Kpne_KpnH Disruption of the pump components KpnGH signficantly decrease resistance to azithromycin, ceftazidime, ciprofloxacin, ertapenem, erythromycin, gentamicin, imipenem, ticarcillin, norfloxacin, polymyxin-B, piperacillin, spectinomycin, tobramycin, and streptomycin. antibiotic_resistance ARO:3004598 Klebsiella pneumoniae KpnGH-TolC ARO:3004598 Disruption of the pump components KpnGH signficantly decrease resistance to azithromycin, ceftazidime, ciprofloxacin, ertapenem, erythromycin, gentamicin, imipenem, ticarcillin, norfloxacin, polymyxin-B, piperacillin, spectinomycin, tobramycin, and streptomycin. PMID:24823362 clcD gene can provide resistance to representatives of five of the six antibiotic groups previously shown to be affected by Cfr. clcD was originally found in Clostridioides difficile and is cfr-like. clcD antibiotic_resistance ARO:3004599 clcD ARO:3004599 clcD gene can provide resistance to representatives of five of the six antibiotic groups previously shown to be affected by Cfr. clcD was originally found in Clostridioides difficile and is cfr-like. PMID:26149991 clcD LnuH is a lincosamide nucleotidyltransferase transferase. LnuH antibiotic_resistance ARO:3004600 LnuH ARO:3004600 LnuH is a lincosamide nucleotidyltransferase transferase. PMID:28843817 LnuH LnuP is a lincosamide nucleotidyltransferase major efflux facilitator. LnuP antibiotic_resistance ARO:3004601 LnuP ARO:3004601 LnuP is a lincosamide nucleotidyltransferase major efflux facilitator. PMID:19684139 LnuP A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. tet(56) antibiotic_resistance ARO:3004603 tet(56) ARO:3004603 A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. PMID:26097034 tet(56) ermZ is an methyltransferase modifying 23S rRNA conferring resistance to Spiramycin. ermZ srm7 srmD antibiotic_resistance ARO:3004605 ermZ ARO:3004605 ermZ is an methyltransferase modifying 23S rRNA conferring resistance to Spiramycin. PMID:18048924 ermZ erm(40) is an adenine RNA methylase and confers intrinsic resistance in Mycobacteria. erm(40) antibiotic_resistance ARO:3004606 erm(40) ARO:3004606 erm(40) is an adenine RNA methylase and confers intrinsic resistance in Mycobacteria. PMID:17005837 erm(40) The cfr groups were determined by Candela et al (2017) by determining the phylogenetic relationship using the neighbour-joining method to compare the cfr-like proteins to cfr. cfr(A) Group antibiotic_resistance ARO:3004607 Cfr Group ARO:3004607 The cfr groups were determined by Candela et al (2017) by determining the phylogenetic relationship using the neighbour-joining method to compare the cfr-like proteins to cfr. PMID:28663118 EreD is an erythromycin esterase protein. Ere(D) EreD antibiotic_resistance ARO:3004608 EreD ARO:3004608 EreD is an erythromycin esterase protein. PMID:26107936 EreD The cfr groups were determined by Candela et al (2017) by determining the phylogenetic relationship using the neighbour-joining method to compare the cfr-like proteins to cfr. antibiotic_resistance ARO:3004609 cfr(B) Group ARO:3004609 The cfr groups were determined by Candela et al (2017) by determining the phylogenetic relationship using the neighbour-joining method to compare the cfr-like proteins to cfr. PMID:28663118 The cfr groups were determined by Candela et al (2017) by determining the phylogenetic relationship using the neighbour-joining method to compare the cfr-like proteins to cfr. antibiotic_resistance ARO:3004610 cfr(C) Group ARO:3004610 The cfr groups were determined by Candela et al (2017) by determining the phylogenetic relationship using the neighbour-joining method to compare the cfr-like proteins to cfr. PMID:28663118 A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. tet(47) tet47 antibiotic_resistance ARO:3004613 tet(47) ARO:3004613 A tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics. PMID:26097034 tet(47) ADC-11 is a class C beta-lactamase found in Acinetobacter baumannii. ADC-11 antibiotic_resistance ARO:3004615 ADC-11 ARO:3004615 ADC-11 Mycoplasma genitalium strain M6320 contains mutations that lead to resistance to fluoroquinolone and macrolide antibiotics. Mgen_23S_MULT antibiotic_resistance ARO:3004616 Mycoplasma genitalium 23S rRNA mutations confers resistance to fluoroquinolone and macrolide antibiotics ARO:3004616 Mycoplasma genitalium strain M6320 contains mutations that lead to resistance to fluoroquinolone and macrolide antibiotics. PMID:18990060 PMID:22532861 PMID:23658265 Mgen_23S_MULT An ADC beta-lactamase and cephalosporinase from Acinetobacter baumannii. ADC-30 antibiotic_resistance ARO:3004617 ADC-30 ARO:3004617 ADC-30 An ADC beta-lactamase and cephalosporinase from Acinetobacter baumannii. ADC-58 antibiotic_resistance ARO:3004618 ADC-58 ARO:3004618 ADC-58 An ADC beta-lactamase and cephalosporinase from Acinetobacter baumannii. ADC-59 antibiotic_resistance ARO:3004619 ADC-59 ARO:3004619 ADC-59 An ADC beta-lactamase and cephalosporinase from Acinetobacter baumannii. ADC-60 antibiotic_resistance ARO:3004620 ADC-60 ARO:3004620 ADC-60 AAC(3)-IIe is a plasmid-encoded aminoglycoside acetyltransferase in E. coli. AAC(3)-IIe aacC2e antibiotic_resistance ARO:3004621 AAC(3)-IIe ARO:3004621 AAC(3)-IIe is a plasmid-encoded aminoglycoside acetyltransferase in E. coli. PMID:20185552 AAC(3)-IIe QnrS10 is a plasmid-mediated quinolone resistance protein. QnrS10 antibiotic_resistance ARO:3004622 QnrS10 ARO:3004622 QnrS10 is a plasmid-mediated quinolone resistance protein. PMID:23648253 QnrS10 AAC(3)-IId is a plasmid-encoded aminoglycoside acetyltransferase in E. coli. AAC(3)-IId aacC2d antibiotic_resistance ARO:3004623 AAC(3)-IId ARO:3004623 AAC(3)-IId is a plasmid-encoded aminoglycoside acetyltransferase in E. coli. PMID:20185552 AAC(3)-IId QnrS11 is a plasmid-mediated quinolone resistance protein. QnrS11 antibiotic_resistance ARO:3004624 QnrS11 ARO:3004624 QnrS11 is a plasmid-mediated quinolone resistance protein. PMID:22470007 QnrS11 QnrS12 is a plasmid-mediated quinolone resistance protein. QnrS12 antibiotic_resistance ARO:3004625 QnrS12 ARO:3004625 QnrS12 is a plasmid-mediated quinolone resistance protein. PMID:29415140 QnrS12 Erm(49) is an rRNA methylase gene. Erm(49) antibiotic_resistance ARO:3004626 Erm(49) ARO:3004626 Erm(49) is an rRNA methylase gene. PMID:23882264 PMID:29500262 Erm(49) QnrS15 is a plasmid-mediated quinolone resistance protein. QnrS15 antibiotic_resistance ARO:3004627 QnrS15 ARO:3004627 QnrS15 is a plasmid-mediated quinolone resistance protein. PMID:29415140 QnrS15 AAC(2')-IIa is a kasugamycin 2' N-acetyltransferase protein found in Burkholderia glumae and Acidovorax avenae isolates. AAC(2')-IIa antibiotic_resistance ARO:3004628 AAC(2')-IIa ARO:3004628 AAC(2')-IIa is a kasugamycin 2' N-acetyltransferase protein found in Burkholderia glumae and Acidovorax avenae isolates. PMID:22660700 AAC(2')-IIa AAC(6')-Im is an aminoglycoside acetyltransferase encoded by plasmids in E. coli, and E. faecium. AAC(6')-Im antibiotic_resistance ARO:3004629 AAC(6')-Im ARO:3004629 AAC(6')-Im is an aminoglycoside acetyltransferase encoded by plasmids in E. coli, and E. faecium. PMID:11557456 AAC(6')-Im Mycoplasma genitalium exhibits multiple mutations in parC which confers resistance to Moxifloxacin. Mgen_parC_MXF antibiotic_resistance ARO:3004630 Mycoplasma genitalium parC mutations confers resistance to Moxifloxacin ARO:3004630 Mycoplasma genitalium exhibits multiple mutations in parC which confers resistance to Moxifloxacin. PMID:15728924 PMID:19567408 PMID:20580532 PMID:23658265 PMID:29883482 Mgen_parC_MXF Mycoplasma Genitalium GyrA mutations confers resistance to fluoroquinolones such as Moxifloxacin. Mgen_gyrA_FLO antibiotic_resistance ARO:3004631 Mycoplasma genitalium gyrA mutation confers resistance to fluoroquinolones ARO:3004631 Mycoplasma Genitalium GyrA mutations confers resistance to fluoroquinolones such as Moxifloxacin. PMID:14506049 PMID:15728924 PMID:23658265 PMID:29883482 Mgen_gyrA_FLO A class ADC beta-lactamase and cephalosporinase from Acinetobacter baumannii. ADC-62 antibiotic_resistance ARO:3004632 ADC-62 ARO:3004632 ADC-62 A class C beta-lactamase and cephalosporinase from Acinetobacter baumannii. ADC-67 antibiotic_resistance ARO:3004633 ADC-67 ARO:3004633 ADC-67 A class C ADC beta-lactamase and cephalosporinase found in Acinetobacter baumannii. ADC-73 antibiotic_resistance ARO:3004634 ADC-73 ARO:3004634 ADC-73 AAC(6')-Il is an aminoglycoside acetyltransferase encoded by plasmids and integrons in Enterobacter cloaecae and Klebsiella aerogenes. AAC(6')-Il aacA7 antibiotic_resistance ARO:3004635 AAC(6')-Il ARO:3004635 AAC(6')-Il is an aminoglycoside acetyltransferase encoded by plasmids and integrons in Enterobacter cloaecae and Klebsiella aerogenes. PMID:7793874 AAC(6')-Il qnrE1 is a member of the qnrE family of plasmid-borne (fluoro)quinolone-resistance genes, with chromosomal origins from Enterobacter spp. qnrE1 antibiotic_resistance ARO:3004636 qnrE1 ARO:3004636 qnrE1 is a member of the qnrE family of plasmid-borne (fluoro)quinolone-resistance genes, with chromosomal origins from Enterobacter spp. PMID:28193666 qnrE1 qnrE2 is a qnrE-member of plasmid-borne (fluoro)quinolone-resistance genes. qnrE2 antibiotic_resistance ARO:3004637 qnrE2 ARO:3004637 qnrE2 is a qnrE-member of plasmid-borne (fluoro)quinolone-resistance genes. PMID:34097486 qnrE2 AAC(6')-I-48 (AAC(6')-Iag) is an aminoglycoside acetyltransferase encoded by integrons in Pseudomonas aeruginosa. AAC(6')-I-48 AAC(6')-Iag aacA48 antibiotic_resistance ARO:3004638 AAC(6')-I-48 ARO:3004638 AAC(6')-I-48 (AAC(6')-Iag) is an aminoglycoside acetyltransferase encoded by integrons in Pseudomonas aeruginosa. PMID:23950962 AAC(6')-I-48 The tetAB genes of the Corynebacterium striatum R-plasmid encode an ABC transporter and confer tetracycline, oxytetracycline, and oxalic resistance. Cstr_tetA antibiotic_resistance ARO:3004639 Corynebacterium striatum tetA ARO:3004639 The tetAB genes of the Corynebacterium striatum R-plasmid encode an ABC transporter and confer tetracycline, oxytetracycline, and oxalic resistance. PMID:10732668 Cstr_tetA A dihydrofolate reductase found in Salmonella Enterica. dfrA15b antibiotic_resistance ARO:3004640 dfrA15b ARO:3004640 A dihydrofolate reductase found in Salmonella Enterica. PMID:15761062 dfrA15b AAC(6')-I-43 (aacA43) is an aminoglycoside acetyltransferase encoded by integrons found in Klebsiella pneumoniae, Escherichia coli, and Enterobacter cloaecae. AAC(6')-I-43 antibiotic_resistance ARO:3004641 AAC(6')-I-43 ARO:3004641 AAC(6')-I-43 (aacA43) is an aminoglycoside acetyltransferase encoded by integrons found in Klebsiella pneumoniae, Escherichia coli, and Enterobacter cloaecae. PMID:21422220 AAC(6')-I-43 A dihydrofolate reductase that confers resistance to trimethoprim. dfrA3b antibiotic_resistance ARO:3004642 dfrA3b ARO:3004642 A dihydrofolate reductase that confers resistance to trimethoprim. PMID:14638506 dfrA3b A 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(K) [Alkalihalobacillus halodurans]. Erm(K) antibiotic_resistance ARO:3004643 Erm(K) ARO:3004643 A 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(K) [Alkalihalobacillus halodurans]. PMID:1713206 Erm(K) dfrA6 is a dihydrofolate reductase that confers resistance to trimethoprim. Found in Proteus mirabilis. Pmir_dfrA6 antibiotic_resistance ARO:3004644 dfrA6 from Proteus mirabilis ARO:3004644 dfrA6 is a dihydrofolate reductase that confers resistance to trimethoprim. Found in Proteus mirabilis. PMID:1941991 Pmir_dfrA6 dfrI is a dihydrofolate reductase that is resistant to trimethoprim. dfrI antibiotic_resistance ARO:3004645 dfrI ARO:3004645 dfrI is a dihydrofolate reductase that is resistant to trimethoprim. PMID:17375195 dfrI AQU-2 is a chromosomally-encoded AQU class C beta-lactamase and cephalosporinase from Aeromonas. AQU-2 antibiotic_resistance ARO:3004647 AQU-2 ARO:3004647 AQU-2 AQU-3 is a chromosomally-encoded AQU class C beta-lactamase and cephalosporinase from. AQU-3 antibiotic_resistance ARO:3004648 AQU-3 ARO:3004648 AQU-3 cfr(B) has been observed in mobile genetic elements in E. faecium and Clostridioides difficile and confers resistance to linezolid, clindamycin, erythromycin, chloramphenicol, and retapamulin. cfr(B) antibiotic_resistance ARO:3004649 cfr(B) ARO:3004649 cfr(B) has been observed in mobile genetic elements in E. faecium and Clostridioides difficile and confers resistance to linezolid, clindamycin, erythromycin, chloramphenicol, and retapamulin. PMID:26248384 cfr(B) Initially reported as a tetracycline-resistant determinant encoded on the plasmid pKQ10 in Enterococcus faecium, tet(U) has since been determined to be a misannotation of a gene product not involved in tetracycline resistance. tetU antibiotic_resistance ARO:3004650 tet(U) ARO:3004650 Initially reported as a tetracycline-resistant determinant encoded on the plasmid pKQ10 in Enterococcus faecium, tet(U) has since been determined to be a misannotation of a gene product not involved in tetracycline resistance. PMID:22491689 PMID:8700968 Listeria monocytogenes EGD-e lin gene for lincomycin resistance ABC-F type ribosomal protection protein, complete CDS. lin antibiotic_resistance ARO:3004651 lin ARO:3004651 Listeria monocytogenes EGD-e lin gene for lincomycin resistance ABC-F type ribosomal protection protein, complete CDS. PMID:32615922 lin ErmO (gene lrm) lincomycin resistance methylase [Streptomyces lividans]. Erm(O)-lrm lrm antibiotic_resistance ARO:3004652 Erm(O)-lrm ARO:3004652 ErmO (gene lrm) lincomycin resistance methylase [Streptomyces lividans]. PMID:1761231 Erm(O)-lrm Class G tetracycline resistance determinant from Vibrio anguillarum. tetR(G) antibiotic_resistance ARO:3004653 tetR(G) ARO:3004653 Class G tetracycline resistance determinant from Vibrio anguillarum. PMID:1479961 tetR(G) SNP causing high-level ERY resistance and low-level CLI resistance. Cdif_23S_MULT antibiotic_resistance ARO:3004654 Clostridioides difficile 23S rRNA with mutation conferring resistance to erythromycin and clindamycin ARO:3004654 SNP causing high-level ERY resistance and low-level CLI resistance. PMID:17509804 Cdif_23S_MULT nimB is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. nimB antibiotic_resistance ARO:3004655 nimB ARO:3004655 nimB is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. PMID:10970359 PMID:8067736 nimB catII is a chloramphenicol acetyltransferase. This particular catII is found in E.coli K-12. Confers resistance to chloramphenicol. Ecol_catII antibiotic_resistance ARO:3004656 catII from Escherichia coli K-12 ARO:3004656 catII is a chloramphenicol acetyltransferase. This particular catII is found in E.coli K-12. Confers resistance to chloramphenicol. PMID:2268278 Ecol_catII catA4 is a chloramphenicol acetyltransferase that confers resistance to chloramphenicol. catA4 antibiotic_resistance ARO:3004657 catA4 ARO:3004657 catA4 is a chloramphenicol acetyltransferase that confers resistance to chloramphenicol. PMID:3900035 catA4 catA8 is a chloramphenicol acetyltransferase that confers resistance to chloramphenicol. catA8 antibiotic_resistance ARO:3004658 catA8 ARO:3004658 catA8 is a chloramphenicol acetyltransferase that confers resistance to chloramphenicol. PMID:11257023 PMID:11735367 PMID:9349809 catA8 NBU2-encoded resistance gene. An MefE homolog in Bacteroides species. Macrolide efflux MFS transporter. Mef(En2) antibiotic_resistance ARO:3004659 Mef(En2) ARO:3004659 NBU2-encoded resistance gene. An MefE homolog in Bacteroides species. Macrolide efflux MFS transporter. PMID:10852890 Mef(En2) catB11 is a chloramphenicol acetyltransferase that confers resistance to chloramphenicol. catB11 antibiotic_resistance ARO:3004660 catB11 ARO:3004660 catB11 is a chloramphenicol acetyltransferase that confers resistance to chloramphenicol. PMID:19416365 catB11 The Bacillus subtilis fosB gene encodes a fosfomycin resistance protein. Saur_FosB antibiotic_resistance ARO:3004661 Staphylococcus aureus FosB ARO:3004661 The Bacillus subtilis fosB gene encodes a fosfomycin resistance protein. PMID:11244082 Saur_FosB MCR-3.3 is a colistin resistance gene variant in the chromosome of an Aeromonas veronii. Conferred polymyxin resistance in both E. Coli and Aeromonas salmonicida. MCR-3.3 antibiotic_resistance ARO:3004662 MCR-3.3 ARO:3004662 MCR-3.3 is a colistin resistance gene variant in the chromosome of an Aeromonas veronii. Conferred polymyxin resistance in both E. Coli and Aeromonas salmonicida. PMID:28848017 MCR-3.3 A fusidic acid resistance determinant in Staphylococcus cohnii. This protein behaves akin to FusB as it is a FusB-type protein. It mediates dissociation of EF-G from the ribosome thus counteracting the action of Fusidic acid. FusF antibiotic_resistance ARO:3004663 FusF ARO:3004663 A fusidic acid resistance determinant in Staphylococcus cohnii. This protein behaves akin to FusB as it is a FusB-type protein. It mediates dissociation of EF-G from the ribosome thus counteracting the action of Fusidic acid. PMID:25313205 FusF cmlA8 is a plasmid that confers resistance to chloramphenicol. cmlA8 antibiotic_resistance ARO:3004665 cmlA8 ARO:3004665 cmlA8 is a plasmid that confers resistance to chloramphenicol. PMID:19107398 cmlA8 pexA is a florfenicol and chloramphenicol resistance gene discovered in Alaskan soil. pexA antibiotic_resistance ARO:3004666 pexA ARO:3004666 pexA is a florfenicol and chloramphenicol resistance gene discovered in Alaskan soil. PMID:20543056 pexA NorA gene cloned from Staphylococcus aureus conferred relatively high resistance to hydrophilic quinolones such as norfloxacin, enoxacin, ofloxacin, and ciprofloxacin in S. aureus and Escherichia coli. Had low or no resistance at all to hydrophobic ones such as nalidixic acid, oxolinic acid, and sparfloxacin in S. aureus and Escherichia coli. Saur_norA antibiotic_resistance ARO:3004667 Staphylococcus aureus norA ARO:3004667 NorA gene cloned from Staphylococcus aureus conferred relatively high resistance to hydrophilic quinolones such as norfloxacin, enoxacin, ofloxacin, and ciprofloxacin in S. aureus and Escherichia coli. Had low or no resistance at all to hydrophobic ones such as nalidixic acid, oxolinic acid, and sparfloxacin in S. aureus and Escherichia coli. PMID:2174864 Saur_norA Located on the chromosome of Aliivibrio salmonicida. Provides low-level resistance to quinolones. QnrAS antibiotic_resistance ARO:3004668 QnrAS ARO:3004668 Located on the chromosome of Aliivibrio salmonicida. Provides low-level resistance to quinolones. PMID:20947314 QnrAS A rRNA methyltransferase conferring high-level evernimicin resistance. emtA antibiotic_resistance ARO:3004669 emtA ARO:3004669 A rRNA methyltransferase conferring high-level evernimicin resistance. PMID:11580839 emtA Subtype of FosB, fosfomycin resistant. S.aureus SA1129 carried a FosB1 identical to S. haemolyticus. FosB1 antibiotic_resistance ARO:3004670 FosB1 ARO:3004670 Subtype of FosB, fosfomycin resistant. S.aureus SA1129 carried a FosB1 identical to S. haemolyticus. PMID:27144405 FosB1 Fosfomycin resistance gene. Shares a high homology with FosB1 and FosB3. FosB4 antibiotic_resistance ARO:3004671 FosB4 ARO:3004671 Fosfomycin resistance gene. Shares a high homology with FosB1 and FosB3. PMID:27144405 FosB4 Fosfomycin resistance gene. High homology with FosB1 and FosB3. FosB5 antibiotic_resistance ARO:3004672 FosB5 ARO:3004672 Fosfomycin resistance gene. High homology with FosB1 and FosB3. PMID:27144405 FosB5 Fosfomycin resistance gene. High homology with FosB1 and FosB3. FosB6 antibiotic_resistance ARO:3004673 FosB6 ARO:3004673 Fosfomycin resistance gene. High homology with FosB1 and FosB3. PMID:27144405 FosB6 A fosfomycin resistance gene. FosD antibiotic_resistance ARO:3004674 FosD ARO:3004674 A fosfomycin resistance gene. PMID:18539327 FosD Expression of cloned aphA15 gene in Escherichia coli reduced the susceptibility to kanamycin and neomycin, as well as to amikacin, netilmicin, and streptomycin. aphA15 antibiotic_resistance ARO:3004675 aphA15 ARO:3004675 Expression of cloned aphA15 gene in Escherichia coli reduced the susceptibility to kanamycin and neomycin, as well as to amikacin, netilmicin, and streptomycin. PMID:11257042 aphA15 The first allele of a 16S rRNA methyltransferase gene, rmtD2, confers a high resistance to all clinically available aminoglycosides. rmtD2 antibiotic_resistance ARO:3004677 rmtD2 ARO:3004677 The first allele of a 16S rRNA methyltransferase gene, rmtD2, confers a high resistance to all clinically available aminoglycosides. PMID:21078935 rmtD2 Aminoglycoside-resistance gene. rmtE antibiotic_resistance ARO:3004678 rmtE ARO:3004678 Aminoglycoside-resistance gene. PMID:20368404 rmtE A 16S rRNA mathyltransferase gene with a single nucleotide mutation compared to rmtE. rmtE2 antibiotic_resistance ARO:3004679 rmtE2 ARO:3004679 A 16S rRNA mathyltransferase gene with a single nucleotide mutation compared to rmtE. PMID:26392485 rmtE2 APH(3')-VIIIa is an aminoglycoside phosphoryltransferase that acts on the 3-OH target of aminoglycosides found in Streptomyces rimosus. APH(3')-VIIIa antibiotic_resistance ARO:3004680 APH(3')-VIIIa ARO:3004680 APH(3')-VIIIa is an aminoglycoside phosphoryltransferase that acts on the 3-OH target of aminoglycosides found in Streptomyces rimosus. PMID:23240563 APH(3')-VIIIa Point mutations in the rpoC region of Clostridioides difficile which confer resistance to vancomycin. Cdif_rpoC_VAN antibiotic_resistance ARO:3004681 Clostridioides difficile rpoC with mutation conferring resistance to vancomycin ARO:3004681 Point mutations in the rpoC region of Clostridioides difficile which confer resistance to vancomycin. PMID:23887866 Cdif_rpoC_VAN Small mobilizable plasmid pALWED1.8 containing a novel variant of the streptomycin/spectinomycin resistance gene. aadA27 antibiotic_resistance ARO:3004682 aadA27 ARO:3004682 Small mobilizable plasmid pALWED1.8 containing a novel variant of the streptomycin/spectinomycin resistance gene. PMID:26896789 aadA27 A novel Tn4551 streptomycin-resistance gene that was phenotypically silent in wild-type Bacteroides; expression could be activated by a trans-acting chromosomal mutation. aadS antibiotic_resistance ARO:3004683 aadS ARO:3004683 A novel Tn4551 streptomycin-resistance gene that was phenotypically silent in wild-type Bacteroides; expression could be activated by a trans-acting chromosomal mutation. PMID:1328814 aadS A mobilized and plasmid-mediated colistin resistance gene and phosphoethanolamine transferase identified from a Salmonella enterica isolate. MCR-9 MCR-9.1 antibiotic_resistance ARO:3004684 MCR-9.1 ARO:3004684 A mobilized and plasmid-mediated colistin resistance gene and phosphoethanolamine transferase identified from a Salmonella enterica isolate. PMID:31064835 MCR-9.1 A plasmid-mediated MCR-1 variant identified from polyclonal clinical Escherichia coli. MCR-1.5 antibiotic_resistance ARO:3004685 MCR-1.5 ARO:3004685 A plasmid-mediated MCR-1 variant identified from polyclonal clinical Escherichia coli. PMID:28678874 MCR-1.5 A plasmid-mediated MCR-1 variant identified from Escherichia coli. MCR-1.7 antibiotic_resistance ARO:3004686 MCR-1.7 ARO:3004686 A plasmid-mediated MCR-1 variant identified from Escherichia coli. PMID:29118748 MCR-1.7 An unpublished MCR-1 variant. MCR-1.8 antibiotic_resistance ARO:3004687 MCR-1.8 ARO:3004687 An unpublished MCR-1 variant. PMID:30053115 MCR-1.8 A plasmid-mediated phosphoethanolamine transferase and MCR-1 variant identified from Escherichia coli as conferring resistance to colistin antibiotics. MCR-1.11 antibiotic_resistance ARO:3004688 MCR-1.11 ARO:3004688 A plasmid-mediated phosphoethanolamine transferase and MCR-1 variant identified from Escherichia coli as conferring resistance to colistin antibiotics. PMID:30053115 MCR-1.11 A plasmid-mediated phosphoethanolamine transferase and MCR-1 variant identified from Escherichia coli and conferring resistance to colistin antibiotics. MCR-1.12 antibiotic_resistance ARO:3004689 MCR-1.12 ARO:3004689 A plasmid-mediated phosphoethanolamine transferase and MCR-1 variant identified from Escherichia coli and conferring resistance to colistin antibiotics. PMID:29052266 PMID:30053115 MCR-1.12 A plasmid-mediated phosphoethanolamine transferase and MCR-1 variant identified from Escherichia coli. MCR-1.13 antibiotic_resistance ARO:3004690 MCR-1.13 ARO:3004690 A plasmid-mediated phosphoethanolamine transferase and MCR-1 variant identified from Escherichia coli. PMID:30053115 MCR-1.13 A plasmid-mediated MCR-3.1 variant. MCR-3.4 antibiotic_resistance ARO:3004691 MCR-3.4 ARO:3004691 A plasmid-mediated MCR-3.1 variant. PMID:30053115 MCR-3.4 aadA10 is a aminoglycoside nucleotidyltransferase gene encoded by plasmids in P. aeruginosa. aadA10 antibiotic_resistance ARO:3004692 aadA10 ARO:3004692 aadA10 is a aminoglycoside nucleotidyltransferase gene encoded by plasmids in P. aeruginosa. PMID:12121911 aadA10 A plasmid-mediated phosphoethanolamine transferase and MCR-3 variant conferring resistance to colistin antibiotics. MCR-3.12 antibiotic_resistance ARO:3004693 MCR-3.12 ARO:3004693 A plasmid-mediated phosphoethanolamine transferase and MCR-3 variant conferring resistance to colistin antibiotics. PMID:29712655 PMID:30053115 MCR-3.12 A plasmid-mediated MCR-4 variant which confers resistance to colistin antibiotics. MCR-4.2 antibiotic_resistance ARO:3004694 MCR-4.2 ARO:3004694 A plasmid-mediated MCR-4 variant which confers resistance to colistin antibiotics. PMID:29635007 PMID:30053115 MCR-4.2 A plasmid-mediated MCR-4 variant and colistin resistance gene from clinical Enterobacteriaceae. MCR-4.3 antibiotic_resistance ARO:3004695 MCR-4.3 ARO:3004695 A plasmid-mediated MCR-4 variant and colistin resistance gene from clinical Enterobacteriaceae. PMID:29237785 PMID:30053115 MCR-4.3 A plasmid-mediated MCR-4 variant and colistin resistance gene. MCR-4.4 antibiotic_resistance ARO:3004696 MCR-4.4 ARO:3004696 A plasmid-mediated MCR-4 variant and colistin resistance gene. PMID:29635007 PMID:30053115 MCR-4.4 A plasmid-mediated MCR-4 variant and colistin resistance gene. MCR-4.5 antibiotic_resistance ARO:3004697 MCR-4.5 ARO:3004697 A plasmid-mediated MCR-4 variant and colistin resistance gene. PMID:29635007 PMID:30053115 MCR-4.5 A plasmid-mediated MCR-5 variant from Escheichia coli which confers resistance to colistin antibiotics. MCR-5.2 antibiotic_resistance ARO:3004698 MCR-5.2 ARO:3004698 A plasmid-mediated MCR-5 variant from Escheichia coli which confers resistance to colistin antibiotics. PMID:29444245 PMID:30053115 MCR-5.2 Streptothricin acetyltransferase gene (STAT gene) that confers streptothricin resistance on Escherichia coli and Bacillus subtilis. sta antibiotic_resistance ARO:3004699 sta ARO:3004699 Streptothricin acetyltransferase gene (STAT gene) that confers streptothricin resistance on Escherichia coli and Bacillus subtilis. PMID:3106324 sta Mutation in a resistance determinant rendering it non-functional. antibiotic_resistance ARO:3004700 mutation in resistance determinant ARO:3004700 An antibiotic cocktail containing beta-lactam penam antibiotic cloxacillin and the cephalosporin ceftazidime. antibiotic_resistance ARO:3004701 ceftazidime-cloxacillin ARO:3004701 An antibiotic cocktail containing the cephalosporin cefepime and the penicillin cloxacillin. antibiotic_resistance ARO:3004702 cefepime-cloxacillin ARO:3004702 An antibiotic cocktail containing beta-lactam penam antibiotic cloxacillin and the beta-lactam carbapenam antibiotic imipenam. antibiotic_resistance ARO:3004703 imipenem-cloxacillin ARO:3004703 aadA8b is an aminoglycoside nucleotidyltransferase gene encoded by plasmids in E. coli; can be created by a recombination event between aadA1 and aadA2. aadA8b antibiotic_resistance ARO:3004704 aadA8b ARO:3004704 aadA8b is an aminoglycoside nucleotidyltransferase gene encoded by plasmids in E. coli; can be created by a recombination event between aadA1 and aadA2. PMID:16291869 aadA8b An antibiotic cocktail containing the cephalosporin antibiotic ceftazidime and the beta-lactamase inhibitor clavulanic acid. PubChem:9575352 ceftazidime-clavulanate antibiotic_resistance ARO:3004705 ceftazidime-clavulanic acid ARO:3004705 Experimental protocol where there is a mutation of resistance determinant and the transformation of a plasmid harbouring resistance determinant into the same strain. antibiotic_resistance ARO:3004706 mutation in resistance determinant with plasmid harbouring resistance determinant ARO:3004706 An antibiotic cocktail containing the cephamycin antibiotic cefoxitin and the beta-lactamase inhibitor clavulanate. antibiotic_resistance ARO:3004707 cefoxitin-clavulanate ARO:3004707 An antibiotic cocktail containing the cephamycin antibiotic cefoxitin and the beta-lactamase inhibitor sulbactam. antibiotic_resistance ARO:3004708 cefoxitin-sulbactam ARO:3004708 An antibiotic cocktail containing the cephamycin antibiotic cefoxitin and the beta-lactamase inhibitor tazobactam. antibiotic_resistance ARO:3004709 cefoxitin-tazobactam ARO:3004709 An antibiotic cocktail containing the cephalosporin antibiotic cefotaxime and the beta-lactamase inhibitor clavulanic acid. cefotaxime-clavulante antibiotic_resistance ARO:3004710 cefotaxime-clavulanic acid ARO:3004710 An antibiotic cocktail containing the cephalosporin antibiotic cefotaxime and the beta-lactamase inhibitor Tazobactam. antibiotic_resistance ARO:3004711 cefotaxime-tazobactam ARO:3004711 An antibiotic cocktail containing the cephalosporin antibiotic ceftazidime and the beta-lactamase inhibitor tazobactam. antibiotic_resistance ARO:3004712 ceftazidime-tazobactam ARO:3004712 An antibiotic cocktail containing the beta-lactam antibiotic aztreonam and the conjugate base of the beta-lactamase inhibitor clavulanic acid (clavulanate). aztreonam-clavulanic acid antibiotic_resistance ARO:3004713 aztreonam-clavulanate ARO:3004713 An antibiotic cocktail containing the beta-lactam antibiotic aztreonam and the beta-lactamase inhibitor tazobactam. antibiotic_resistance ARO:3004714 aztreonam-tazobactam ARO:3004714 vga(E) gene variant that confers resistance to pleuromutilins, lincosamides and streptogramin A antibiotics in staphylococci. Scoh_vga(E) antibiotic_resistance ARO:3004715 vga(E) Staphylococcus cohnii ARO:3004715 vga(E) gene variant that confers resistance to pleuromutilins, lincosamides and streptogramin A antibiotics in staphylococci. PMID:24324222 Scoh_vga(E) Antibiotic similar to clorobiocin, but with vanillic acid as the acyl component instead of crenelated 4-hydroxybenzoic acid. antibiotic_resistance ARO:3004716 Vanillobiocin ARO:3004716 Antibiotic similar to clorobiocin, but with vanillic acid as the acyl component instead of crenelated 4-hydroxybenzoic acid. PMID:15152806 Antibiotic similar to clorobiocin, but with vanillic acid as the acyl component instead of crenelated 4-hydroxybenzoic acid. different from vanillobiocin by the [psition of the pyrrole unit attached to the sugar moiety of the antibiotic. antibiotic_resistance ARO:3004717 Isovanillobiocin ARO:3004717 Antibiotic similar to clorobiocin, but with vanillic acid as the acyl component instead of crenelated 4-hydroxybenzoic acid. different from vanillobiocin by the [psition of the pyrrole unit attached to the sugar moiety of the antibiotic. PMID:15152806 Antibiotic similar to clorobiocin, but with vanillic acid as the acyl component instead of crenelated 4-hydroxybenzoic acid. Declovanillobiocin lacks the chlorine atom at the aminocoumarin ring compared to vanillobiocin. antibiotic_resistance ARO:3004718 Declovanillobiocin ARO:3004718 Antibiotic similar to clorobiocin, but with vanillic acid as the acyl component instead of crenelated 4-hydroxybenzoic acid. Declovanillobiocin lacks the chlorine atom at the aminocoumarin ring compared to vanillobiocin. PMID:15152806 A tetracyline resistance gene located on an approximately 300-kb plasmid, designated p47AB. It inactivates all tetracyclines, including tigecycline, eravacycline, and omadacycline.Adjacent to insertion sequence ISVsa3 on the conjugative plasmid. tet(X3) tetX3 antibiotic_resistance ARO:3004719 tet(X3) ARO:3004719 A tetracyline resistance gene located on an approximately 300-kb plasmid, designated p47AB. It inactivates all tetracyclines, including tigecycline, eravacycline, and omadacycline.Adjacent to insertion sequence ISVsa3 on the conjugative plasmid. PMID:31133751 tet(X3) A tetracyline resistance gene located on an approximately 180-kb plasmid, designated p47EC. It inactivates all tetracyclines, including tigecycline, eravacycline, and omadacycline.Adjacent to insertion sequence ISVsa3 on the conjugative plasmid. tet(X4) tetX4 antibiotic_resistance ARO:3004720 tet(X4) ARO:3004720 A tetracyline resistance gene located on an approximately 180-kb plasmid, designated p47EC. It inactivates all tetracyclines, including tigecycline, eravacycline, and omadacycline.Adjacent to insertion sequence ISVsa3 on the conjugative plasmid. PMID:31133751 tet(X4) RpsA, the 30S ribosomal protein S1 of Mycobacterium tuberculosis, is involved in trans-translation and is targeted by pyrazinonic acid, the active form of the antibiotic pyrazinamide, which disrupts the initiation of mRNA translation. Mutations in the amino acid sequence of rpsA can confer resistance to pyrazinamide maintaining rpsA function. Mtub_rpsA_PZA Rv1630 antibiotic_resistance ARO:3004721 Mycobacterium tuberculosis rpsA mutations conferring resistance to pyrazinamide ARO:3004721 RpsA, the 30S ribosomal protein S1 of Mycobacterium tuberculosis, is involved in trans-translation and is targeted by pyrazinonic acid, the active form of the antibiotic pyrazinamide, which disrupts the initiation of mRNA translation. Mutations in the amino acid sequence of rpsA can confer resistance to pyrazinamide maintaining rpsA function. PMID:29921403 PMID:30337678 PMID:30402208 PMID:30858213 PMID:31097767 Mtub_rpsA_PZA The 30S ribosomal protein S1 of Mycobacterium tuberculosis is required for mRNA translation initiation, playing a particular role in trans-translation. Mutations to rpsA prevent pyrazinoic acid, the active form of pyrazinamide catalyzed by pncA, from targeting RpsA to inhibit translation. Ribosomal protein S1 antibiotic_resistance ARO:3004722 pyrazinamide resistant rpsA ARO:3004722 The 30S ribosomal protein S1 of Mycobacterium tuberculosis is required for mRNA translation initiation, playing a particular role in trans-translation. Mutations to rpsA prevent pyrazinoic acid, the active form of pyrazinamide catalyzed by pncA, from targeting RpsA to inhibit translation. PMID:21835980 PMID:29921403 A method to determine microbial susceptibility to antibiotics in which test bacteria is inoculated onto an agar plate that contains a concentration gradient of antibiotic. The minimum inhibitory concentration of antibiotic is assessed. antibiotic_resistance ARO:3004723 gradient plate method ARO:3004723 A method to determine microbial susceptibility to antibiotics in which test bacteria is inoculated onto an agar plate that contains a concentration gradient of antibiotic. The minimum inhibitory concentration of antibiotic is assessed. PMID:12999676 An antibiotic cocktail containing the cephalosporin antibiotic ceftolozane and the beta-lactamase inhibitor tazobactam. antibiotic_resistance ARO:3004724 ceftolozane-tazobactam ARO:3004724 Point mutations in rpoC, an RNA polymerase subunit, which confer resistance to vancomycin. antibiotic_resistance ARO:3004725 vancomycin-resistant beta prime subunit of RNA polymerase (rpoC) ARO:3004725 Cefpirome is a fourth generation cephalosporin with activity against methicillin-susceptible Staphylococcus aureus, coagulase-negative staphylococci and viridans group streptococci, and in vitro activity towards Streptococcus pneumoniae. CAS:84957-29-9 ChEBI:3503 ChEMBL:CHEMBL65794 PubChem:5479539 antibiotic_resistance ARO:3004726 cefpirome ARO:3004726 Cefpirome is a fourth generation cephalosporin with activity against methicillin-susceptible Staphylococcus aureus, coagulase-negative staphylococci and viridans group streptococci, and in vitro activity towards Streptococcus pneumoniae. PMID:9211085 Cefsulodin is a third generation cephalosporin with with activity against Pseudomonas spp., but little activity against other Gram-negative bacteria. CAS:62587-73-9 ChEBI:3507 ChEMBL:CHEMBL3351077 PubChem:5284530 antibiotic_resistance ARO:3004727 cefsulodin ARO:3004727 Cefsulodin is a third generation cephalosporin with with activity against Pseudomonas spp., but little activity against other Gram-negative bacteria. PMID:119787 Carumonam is a monobactam antibiotic. It has activity towards Gram-negative bacteria with negligible activity towards Gram-postitive bacteria. CAS:87638-04-8 ChEBI:55486 ChEMBL:CHEMBL1614658 PubChem:6540466 antibiotic_resistance ARO:3004728 carumonam ARO:3004728 Carumonam is a monobactam antibiotic. It has activity towards Gram-negative bacteria with negligible activity towards Gram-postitive bacteria. PMID:4073864 A monobactam with potent activity against Enterobacteriaceae. Stable to metallo-B-lactamases and serine carbapenemases resulting in potency against the majority of extended-spectrum B-lactamase-producing and carbapenem-resistant Enterobacteriaceae strains tested. PubChem:118380292 antibiotic_resistance ARO:3004729 LYS228 ARO:3004729 A monobactam with potent activity against Enterobacteriaceae. Stable to metallo-B-lactamases and serine carbapenemases resulting in potency against the majority of extended-spectrum B-lactamase-producing and carbapenem-resistant Enterobacteriaceae strains tested. PMID:30038040 A pleuromutilin resistance gene encoding a predicted ABC-F transporter. The presence of inhibitory or sub-inhibitory concentrations of tiamulin showed that tva(A) confers reduced pleuromutilin susceptibility that does not lead to clinical resistance but facilitates the development of higher-level resistance via mutations in genes encoding ribosome-associated functions. tva(A) antibiotic_resistance ARO:3004730 tva(A) ARO:3004730 A pleuromutilin resistance gene encoding a predicted ABC-F transporter. The presence of inhibitory or sub-inhibitory concentrations of tiamulin showed that tva(A) confers reduced pleuromutilin susceptibility that does not lead to clinical resistance but facilitates the development of higher-level resistance via mutations in genes encoding ribosome-associated functions. PMID:29971045 tva(A) A fluoroquinolone with potent activity against Gram-positive pathogens. Showed the most potent in vitro and in vivo activities against drug-resistant Streptococcus pneumoniae. One of the most potent antibacterial agent against penicillin-resistant S. pneumoniae in a murine systemic infection model. ChEMBL:CHEMBL2107811 PubChem:54556623 antibiotic_resistance ARO:3004731 Zabofloxacin ARO:3004731 A fluoroquinolone with potent activity against Gram-positive pathogens. Showed the most potent in vitro and in vivo activities against drug-resistant Streptococcus pneumoniae. One of the most potent antibacterial agent against penicillin-resistant S. pneumoniae in a murine systemic infection model. PMID:16873394 PMID:27869677 An 8-cyano-substituted fluoroquinolone with increased antibacterial activity in acidic conditions in contrast to other fluoroquinolones which demonstrate reduced activity in lower pH. Finafloxacin showed increased bactericidal activity at pH 5 in comparison to pH 7 and ciprofloxacin at pH 5 in vitro. CAS:209342-40-5 ChEBI:85176 ChEMBL:CHEMBL1908370 PubChem:11567473 antibiotic_resistance ARO:3004732 Finafloxacin ARO:3004732 An 8-cyano-substituted fluoroquinolone with increased antibacterial activity in acidic conditions in contrast to other fluoroquinolones which demonstrate reduced activity in lower pH. Finafloxacin showed increased bactericidal activity at pH 5 in comparison to pH 7 and ciprofloxacin at pH 5 in vitro. PMID:21596526 PMID:28438936 A C-8-methoxy non-fluorinated quinolone exhibiting potent antibacterial activities against Gram-positive, including MRSA and fluoroquinolone-resistant MRSA, Gram-negative, and atypical pathogens, especially methicillin-resistant Staphylococcus aureus. CAS:378746-64-6 ChEBI:136053 ChEMBL:CHEMBL1213456 PubChem:11993740 antibiotic_resistance ARO:3004733 Nemonoxacin ARO:3004733 A C-8-methoxy non-fluorinated quinolone exhibiting potent antibacterial activities against Gram-positive, including MRSA and fluoroquinolone-resistant MRSA, Gram-negative, and atypical pathogens, especially methicillin-resistant Staphylococcus aureus. PMID:22650326 PMID:25529577 ARL-1 is a beta-lactamase gene found in Staphylococcus Arlettae. ARL-1 antibiotic_resistance ARO:3004734 ARL-1 ARO:3004734 ARL-1 is a beta-lactamase gene found in Staphylococcus Arlettae. PMID:28497118 ARL-1 ARL-2 is a beta-lactamase gene found in Staphylococcus Arlettae. ARL-2 antibiotic_resistance ARO:3004735 ARL-2 ARO:3004735 ARL-2 is a beta-lactamase gene found in Staphylococcus Arlettae. PMID:28497118 ARL-2 ARL-3 is a beta-lactamase gene found in Staphylococcus arlettae. ARL-3 antibiotic_resistance ARO:3004736 ARL-3 ARO:3004736 ARL-3 is a beta-lactamase gene found in Staphylococcus arlettae. PMID:28497118 ARL-3 ARL-4 is a beta-lactamase gene found in Staphylococcus arlettae. ARL-4 antibiotic_resistance ARO:3004737 ARL-4 ARO:3004737 ARL-4 is a beta-lactamase gene found in Staphylococcus arlettae. PMID:28497118 ARL-4 ARL-5 is a beta-lactamase gene found in Staphylococcus arlettae. ARL-5 antibiotic_resistance ARO:3004738 ARL-5 ARO:3004738 ARL-5 is a beta-lactamase gene found in Staphylococcus arlettae. PMID:28497118 ARL-5 ARL-6 is a beta-lactamase gene found in Staphylococcus arlettae. ARL-6 antibiotic_resistance ARO:3004739 ARL-6 ARO:3004739 ARL-6 is a beta-lactamase gene found in Staphylococcus arlettae. PMID:28497118 ARL-6 AST-1 is a broad-spectrum beta-lactamase gene found in Nocardia asteroides. AST-1 antibiotic_resistance ARO:3004740 AST-1 ARO:3004740 AST-1 is a broad-spectrum beta-lactamase gene found in Nocardia asteroides. PMID:11181374 AST-1 A family of beta-lactamase known for their broad spectrum resistance profile. antibiotic_resistance ARO:3004741 AST Beta-lactamase ARO:3004741 A family of beta-lactamase known for their broad spectrum resistance profile. PMID:11181374 ARL beta-lactamase is an AMR Gene Family associated with Staphylococcus arlettae. antibiotic_resistance ARO:3004742 ARL Beta-lactamase ARO:3004742 ARL beta-lactamase is an AMR Gene Family associated with Staphylococcus arlettae. PMID:28497118 MIR-23, originally described as AZECL-25, is a class C beta-lactamase that is found in Enterobacter cloacae. AZECL-25 MIR-23 antibiotic_resistance ARO:3004745 MIR-23 ARO:3004745 MIR-23, originally described as AZECL-25, is a class C beta-lactamase that is found in Enterobacter cloacae. PMID:25022578 MIR-23 BAT is a class D beta-lactamase. antibiotic_resistance ARO:3004746 BAT Beta-lactamase ARO:3004746 BAT is a class D beta-lactamase. PMID:21464989 BAT-1 is a class D beta-lactamase found in Bacillus atrophaeus. BAT-1 antibiotic_resistance ARO:3004747 BAT-1 ARO:3004747 BAT-1 is a class D beta-lactamase found in Bacillus atrophaeus. PMID:21464989 PMID:22843588 BAT-1 BCL beta-lactamase is a class A beta-lactamase. antibiotic_resistance ARO:3004748 BCL Beta-lactamase ARO:3004748 BCL beta-lactamase is a class A beta-lactamase. PMID:12654668 PMID:17846134 BCL-1 is a class A beta-lactamase found in Alkalihalobacillus clausii. BCL-1 antibiotic_resistance ARO:3004749 BCL-1 ARO:3004749 BCL-1 is a class A beta-lactamase found in Alkalihalobacillus clausii. PMID:12654668 PMID:17846134 BCL-1 BES beta-lactamase is a class A beta-lactamase family. antibiotic_resistance ARO:3004750 BES Beta-lactamase ARO:3004750 BES beta-lactamase is a class A beta-lactamase family. PMID:11036023 BES-1 is a class A beta-lactamase that is found in Serratia marcescens. BES-1 antibiotic_resistance ARO:3004751 BES-1 ARO:3004751 BES-1 is a class A beta-lactamase that is found in Serratia marcescens. PMID:11036023 BES-1 BIC is a class A beta-lactamase conferring resistance to carbapenem. antibiotic_resistance ARO:3004752 BIC Beta-lactamase ARO:3004752 BIC is a class A beta-lactamase conferring resistance to carbapenem. PMID:19901091 BIC-1 is a beta-lactamase conferring resistance to carbapenems that is found in Pseudomonas fluorescens. BIC-1 antibiotic_resistance ARO:3004753 BIC-1 ARO:3004753 BIC-1 is a beta-lactamase conferring resistance to carbapenems that is found in Pseudomonas fluorescens. PMID:19901091 BIC-1 BIL beta-lactamase is plasmid-borne and is a class C beta-lactamase. antibiotic_resistance ARO:3004754 BIL Beta-lactamase ARO:3004754 BIL beta-lactamase is plasmid-borne and is a class C beta-lactamase. PMID:8067761 BIL-1 is a plasmid-borne beta-lactamase that is also a class C beta-lactamase. BIL-1 antibiotic_resistance ARO:3004755 BIL-1 ARO:3004755 BIL-1 is a plasmid-borne beta-lactamase that is also a class C beta-lactamase. PMID:8067761 BIL-1 BKC beta-lactamase is a class A beta-lactamase. antibiotic_resistance ARO:3004756 BKC Beta-lactamase ARO:3004756 BKC beta-lactamase is a class A beta-lactamase. PMID:26055384 BKC-1 is a beta-lactamase conferring resistance to carbapenem and is found in Brazilian Klebsiella. BKC-1 antibiotic_resistance ARO:3004757 BKC-1 ARO:3004757 BKC-1 is a beta-lactamase conferring resistance to carbapenem and is found in Brazilian Klebsiella. PMID:26055384 BKC-1 BPU is a class D beta lactamase gene family. antibiotic_resistance ARO:3004758 BPU Beta-lactamase ARO:3004758 BPU is a class D beta lactamase gene family. PMID:17895969 PMID:23799069 PMID:23812891 BPU-1 is a class D beta-lactamase found in Bacillus pumilus. BPU-1 antibiotic_resistance ARO:3004759 BPU-1 ARO:3004759 BPU-1 is a class D beta-lactamase found in Bacillus pumilus. PMID:17895969 PMID:23799069 PMID:23812891 PMID:27351589 PMID:29884123 BPU-1 BRO is a class A beta-lactamase that is found in M.catarrhalis. antibiotic_resistance ARO:3004760 BRO Beta-lactamase ARO:3004760 BRO is a class A beta-lactamase that is found in M.catarrhalis. PMID:8849261 BRO-1 is a class A beta-lactamase found in M.catarrhalis. BRO-1 antibiotic_resistance ARO:3004761 BRO-1 ARO:3004761 BRO-1 is a class A beta-lactamase found in M.catarrhalis. PMID:8849261 BRO-1 BRO-2 is a class A beta-lactamase found in M.catarrhalis. BRO-2 antibiotic_resistance ARO:3004762 BRO-2 ARO:3004762 BRO-2 is a class A beta-lactamase found in M.catarrhalis. PMID:8849261 BRO-2 CBP is a class A beta-lactamase family found in C. botulinum. antibiotic_resistance ARO:3004763 CBP beta-lactamase ARO:3004763 CBP-1 is a class A beta-lactamase gene found in C. botulinum. CBP-1 antibiotic_resistance ARO:3004764 CBP-1 ARO:3004764 CBP-1 CGA is a class A beta-lactamase family that is found in Chryseobacterium gleum. antibiotic_resistance ARO:3004765 CGA beta-lactamase ARO:3004765 CGA is a class A beta-lactamase family that is found in Chryseobacterium gleum. PMID:11897576 CGA-1 is a class A beta-lactamase gene found in Chryseobacterium gleum. CGA-1 antibiotic_resistance ARO:3004766 CGA-1 ARO:3004766 CGA-1 is a class A beta-lactamase gene found in Chryseobacterium gleum. PMID:11897576 CGA-1 CIA is a class A beta-lactamase gene family found in Chryseobacterium indologenes. antibiotic_resistance ARO:3004767 CIA beta-lactamase ARO:3004767 CIA is a class A beta-lactamase gene family found in Chryseobacterium indologenes. PMID:22083470 CIA-1 is a class A beta-lactamase gene found in Chryseobacterium indologenes. CIA-1 antibiotic_resistance ARO:3004768 CIA-1 ARO:3004768 CIA-1 is a class A beta-lactamase gene found in Chryseobacterium indologenes. PMID:22083470 CIA-1 CIA-2 is a class A beta-lactamase gene found in Chryseobacterium indologenes. CIA-2 antibiotic_resistance ARO:3004769 CIA-2 ARO:3004769 CIA-2 is a class A beta-lactamase gene found in Chryseobacterium indologenes. PMID:22083470 CIA-2 CIA-3 is a class A beta-lactamase gene found in Chryseobacterium indologenes. CIA-3 antibiotic_resistance ARO:3004770 CIA-3 ARO:3004770 CIA-3 is a class A beta-lactamase gene found in Chryseobacterium indologenes. PMID:22083470 CIA-3 CIA-4 is a class A beta-lactamase gene found in Chryseobacterium indologenes. CIA-4 antibiotic_resistance ARO:3004771 CIA-4 ARO:3004771 CIA-4 is a class A beta-lactamase gene found in Chryseobacterium indologenes. PMID:22083470 CIA-4 CKO is a class A beta-lactamase gene family found in Citrobacter koseri. antibiotic_resistance ARO:3004772 CKO beta-lactamase ARO:3004772 CKO is a class A beta-lactamase gene family found in Citrobacter koseri. PMID:16445758 CKO-1 is a class A beta-lactamase gene found in Citrobacter koseri. CKO-1 antibiotic_resistance ARO:3004773 CKO-1 ARO:3004773 CKO-1 is a class A beta-lactamase gene found in Citrobacter koseri. PMID:16445758 CKO-1 CME is a class A beta-lactamase gene family belonging to Chryseobacterium meningosepticum. antibiotic_resistance ARO:3004774 CME beta-lactamase ARO:3004774 CME is a class A beta-lactamase gene family belonging to Chryseobacterium meningosepticum. PMID:10471563 CME-1 is a class A beta-lactamase gene belonging to Chryseobacterium meningosepticum. CME-1 antibiotic_resistance ARO:3004775 CME-1 ARO:3004775 CME-1 is a class A beta-lactamase gene belonging to Chryseobacterium meningosepticum. PMID:10471563 CME-1 CMH is a class C beta-lactamase gene family belonging to Enterobacter cloacae. antibiotic_resistance ARO:3004776 CMH beta-lactamase ARO:3004776 CMH-1 is a class C beta-lactamase gene found in Enterobacter cloacae. CMH-1 antibiotic_resistance ARO:3004777 CMH-1 ARO:3004777 CMH-1 CMY-135 is a class C beta-lactamase that confers resistance to cephamycin. CMY-135 antibiotic_resistance ARO:3004778 CMY-135 ARO:3004778 CMY-135 is a class C beta-lactamase that confers resistance to cephamycin. PMID:26126492 CMY-135 DES is a class A beta-lactamase gene family found in Desulfovibrio desulfuricans. antibiotic_resistance ARO:3004779 DES beta-lactamase ARO:3004779 DES is a class A beta-lactamase gene family found in Desulfovibrio desulfuricans. PMID:12234847 DES-1 is a class A beta-lactamase gene found in Desulfovibrio desulfuricans. DES-1 antibiotic_resistance ARO:3004780 DES-1 ARO:3004780 DES-1 is a class A beta-lactamase gene found in Desulfovibrio desulfuricans. PMID:12234847 DES-1 ERP is a class A beta-lactamase gene family found in Erwinia persicina. antibiotic_resistance ARO:3004781 ERP beta-lactamase ARO:3004781 ERP is a class A beta-lactamase gene family found in Erwinia persicina. PMID:12384342 ERP-1 is a class A beta-lactamase gene found in Erwinia persicina. ERP-1 antibiotic_resistance ARO:3004782 ERP-1 ARO:3004782 ERP-1 is a class A beta-lactamase gene found in Erwinia persicina. PMID:12384342 ERP-1 FAR is a class A extended spectrum beta-lactamase gene family found in Nocardia farcinica. antibiotic_resistance ARO:3004783 FAR beta-lactamase ARO:3004783 FAR-1 is a class A beta-lactamase gene found in Nocardia farcinica. FAR-1 antibiotic_resistance ARO:3004784 FAR-1 ARO:3004784 FAR-1 FIM is a metallo-beta-lactamase gene family found in Pseudomonas aeruginosa. antibiotic_resistance ARO:3004785 FIM beta-lactamase ARO:3004785 FIM is a metallo-beta-lactamase gene family found in Pseudomonas aeruginosa. PMID:23114762 FIM-1 is a metallo-beta-lactamase gene found in Pseudomonas aeruginosa from isolates in Italy. FIM-1 antibiotic_resistance ARO:3004786 FIM-1 ARO:3004786 FIM-1 is a metallo-beta-lactamase gene found in Pseudomonas aeruginosa from isolates in Italy. PMID:23114762 FIM-1 FONA is a class A beta-lactamase gene family found in Serratia fonticola. antibiotic_resistance ARO:3004787 FONA beta-lactamase ARO:3004787 FONA-1 is a class A beta-lactamase gene found in Serratia fonticola. FONA-1 antibiotic_resistance ARO:3004788 FONA-1 ARO:3004788 FONA-1 FONA-2 is a class A beta-lactamase gene found in Serratia fonticola. FONA-2 antibiotic_resistance ARO:3004789 FONA-2 ARO:3004789 FONA-2 FONA-3 is a class A beta-lactamase gene found in Serratia fonticola. FONA-3 antibiotic_resistance ARO:3004790 FONA-3 ARO:3004790 FONA-3 FONA-4 is a class A beta-lactamase gene found in Serratia fonticola. FONA-4 antibiotic_resistance ARO:3004791 FONA-4 ARO:3004791 FONA-4 FONA-5 is a class A beta-lactamase gene found in Serratia fonticola. FONA-5 antibiotic_resistance ARO:3004792 FONA-5 ARO:3004792 FONA-5 FONA-6 is a class A beta-lactamase gene found in Serratia fonticola. FONA-6 antibiotic_resistance ARO:3004793 FONA-6 ARO:3004793 FONA-6 FPH is a carbapenem-hydrolyzing class A beta-lactamase found in Francisella philomiragia. antibiotic_resistance ARO:3004794 FPH beta-lactamase ARO:3004794 FPH is a carbapenem-hydrolyzing class A beta-lactamase found in Francisella philomiragia. PMID:25931589 FPH-1 is a carbapenem-hydrolyzing class A beta-lactamase gene found in Francisella philomiragia. FPH-1 antibiotic_resistance ARO:3004795 FPH-1 ARO:3004795 FPH-1 is a carbapenem-hydrolyzing class A beta-lactamase gene found in Francisella philomiragia. PMID:25931589 FPH-1 FRI is a carbapenem-Hydrolyzing Class A beta-Lactamase from Enterobacter cloacae. antibiotic_resistance ARO:3004796 FRI beta-lactamase ARO:3004796 FRI is a carbapenem-Hydrolyzing Class A beta-Lactamase from Enterobacter cloacae. PMID:26392482 FRI-1 is a carbapenem-hydrolyzing Class A beta-lactamase found in Enterobacter cloacae. FRI-1 antibiotic_resistance ARO:3004797 FRI-1 ARO:3004797 FRI-1 is a carbapenem-hydrolyzing Class A beta-lactamase found in Enterobacter cloacae. PMID:26392482 FRI-1 FRI-2 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter asburiae. FRI-2 antibiotic_resistance ARO:3004798 FRI-2 ARO:3004798 FRI-2 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter asburiae. PMID:30060114 FRI-2 FRI-3 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter cloacae. FRI-3 antibiotic_resistance ARO:3004799 FRI-3 ARO:3004799 FRI-3 FTU is a class A beta-lactamase gene family found in Francisella tularensis. antibiotic_resistance ARO:3004800 FTU beta-lactamase ARO:3004800 FTU is a class A beta-lactamase gene family found in Francisella tularensis. PMID:15640799 FTU-1 is a class A beta-lactamase gene found in Francisella tularensis. It causes Tularemia. FTU-1 antibiotic_resistance ARO:3004801 FTU-1 ARO:3004801 FTU-1 is a class A beta-lactamase gene found in Francisella tularensis. It causes Tularemia. PMID:15640799 PMID:20140244 FTU-1 GOB-10 is a class B beta-lactamase gene found in Chryseobacterium meningosepticum. GOB-10 antibiotic_resistance ARO:3004802 GOB-10 ARO:3004802 GOB-10 is a class B beta-lactamase gene found in Chryseobacterium meningosepticum. PMID:20571954 GOB-10 GOB-11 is a class B beta-lactamase gene found in Chryseobacterium meningosepticum. GOB-11 antibiotic_resistance ARO:3004803 GOB-11 ARO:3004803 GOB-11 is a class B beta-lactamase gene found in Chryseobacterium meningosepticum. PMID:20571954 GOB-11 GOB-12 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. GOB-12 antibiotic_resistance ARO:3004804 GOB-12 ARO:3004804 GOB-12 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. PMID:20571954 GOB-12 GOB-13 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. GOB-13 antibiotic_resistance ARO:3004805 GOB-13 ARO:3004805 GOB-13 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. PMID:20571954 GOB-13 GOB-14 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. GOB-14 antibiotic_resistance ARO:3004806 GOB-14 ARO:3004806 GOB-14 GOB-15 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. GOB-15 antibiotic_resistance ARO:3004807 GOB-15 ARO:3004807 GOB-15 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. PMID:20571954 GOB-15 GOB-16 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. GOB-16 antibiotic_resistance ARO:3004808 GOB-16 ARO:3004808 GOB-16 GOB-2 is class B beta-lactamase gene found in Elizabethkingia meningoseptica. GOB-2 antibiotic_resistance ARO:3004809 GOB-2 ARO:3004809 GOB-2 is class B beta-lactamase gene found in Elizabethkingia meningoseptica. PMID:10858348 GOB-2 GOB-3 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. GOB-3 antibiotic_resistance ARO:3004810 GOB-3 ARO:3004810 GOB-3 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. PMID:10858348 GOB-3 GOB-4 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. GOB-4 antibiotic_resistance ARO:3004811 GOB-4 ARO:3004811 GOB-4 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. PMID:10858348 GOB-4 GOB-5 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. GOB-5 antibiotic_resistance ARO:3004812 GOB-5 ARO:3004812 GOB-5 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. PMID:10858348 GOB-5 GOB-6 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. GOB-6 antibiotic_resistance ARO:3004813 GOB-6 ARO:3004813 GOB-6 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. PMID:10858348 GOB-6 GOB-7 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. GOB-7 antibiotic_resistance ARO:3004814 GOB-7 ARO:3004814 GOB-7 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. PMID:10858348 GOB-7 GOB-8 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. GOB-8 antibiotic_resistance ARO:3004815 GOB-8 ARO:3004815 GOB-8 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. PMID:20571954 GOB-8 GOB-9 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. GOB-9 antibiotic_resistance ARO:3004816 GOB-9 ARO:3004816 GOB-9 is a class B beta-lactamase gene found in Elizabethkingia meningoseptica. PMID:20571954 GOB-9 IMP-52 is a class B metallo-beta-lactamase found in Escherichia coli. IMP-52 antibiotic_resistance ARO:3004823 IMP-52 ARO:3004823 IMP-52 LAP is a Ambler Class A beta-lactamase gene family that confers resistance to beta-lactams. antibiotic_resistance ARO:3004824 LAP beta-lactamase ARO:3004824 LAP is a Ambler Class A beta-lactamase gene family that confers resistance to beta-lactams. PMID:16982792 PMID:17116662 LAP-1 is an Ambler Class A beta-lactamase gene. LAP-1 antibiotic_resistance ARO:3004825 LAP-1 ARO:3004825 LAP-1 is an Ambler Class A beta-lactamase gene. PMID:16982792 PMID:17116662 LAP-1 LAP-2 is an Ambler Class A beta-lactamase gene. LAP-2 antibiotic_resistance ARO:3004826 LAP-2 ARO:3004826 LAP-2 is an Ambler Class A beta-lactamase gene. PMID:18550213 LAP-2 LEN-35 is a Class A beta-lactamase gene found in Klebsiella variicola. LEN-35 antibiotic_resistance ARO:3004827 LEN-35 ARO:3004827 LEN-35 LEN-36 is a class A beta-lactamase gene found in Klebsiella variicola. LEN-36 antibiotic_resistance ARO:3004828 LEN-36 ARO:3004828 LEN-36 LEN-37 is a Class A beta-lactamase gene found in Klebsiella variicola. LEN-37 antibiotic_resistance ARO:3004829 LEN-37 ARO:3004829 LEN-37 PBP2 is a penicillin-binding protein and beta-lactam resistance enzyme encoded by the penA gene, due to mutations can cause resistance to various drugs such as Penicillin and Ceftriaxone. Ngon_PBP2_BLA penA antibiotic_resistance ARO:3004832 Neisseria gonorrhoeae PBP2 conferring resistance to beta-lactam antibiotics ARO:3004832 PBP2 is a penicillin-binding protein and beta-lactam resistance enzyme encoded by the penA gene, due to mutations can cause resistance to various drugs such as Penicillin and Ceftriaxone. PMID:20511367 PMID:22155830 PMID:23587946 PMID:25403720 PMID:25845238 PMID:34013864 Ngon_PBP2_BLA Point mutation in Neisseria gonorrhoea PBP1 (ponA) decreases affinity between beta-lactam antibiotic molecule and PBP1, thereby conferring resistance to beta-lactam antibiotics. Ngon_PBP1_BLA ponA antibiotic_resistance ARO:3004833 Neisseria gonorrhoeae PBP1 conferring resistance to beta-lactam antibiotics ARO:3004833 Point mutation in Neisseria gonorrhoea PBP1 (ponA) decreases affinity between beta-lactam antibiotic molecule and PBP1, thereby conferring resistance to beta-lactam antibiotics. PMID:11850260 Ngon_PBP1_BLA PilQ is an important gonococcal outer membrane component, member of secretin protein family, and involved in Type IV pilus formation. Ngon_pilQ_BLA penC mutation antibiotic_resistance ARO:3004835 Neisseria gonorrhoeae pilQ gene conferring resistance to beta-lactam ARO:3004835 PilQ is an important gonococcal outer membrane component, member of secretin protein family, and involved in Type IV pilus formation. PMID:16101998 Ngon_pilQ_BLA Point mutation in the 23S rRNA of Neisseria gonorrhoea shown to confer resistance to azithromycin, a macrolide type antibiotic. Ngon_23S_AZM antibiotic_resistance ARO:3004836 Neisseria gonorrhoeae 23S rRNA with mutation conferring resistance to azithromycin ARO:3004836 Point mutation in the 23S rRNA of Neisseria gonorrhoea shown to confer resistance to azithromycin, a macrolide type antibiotic. PMID:10508026 PMID:20585125 PMID:25394255 PMID:26601852 PMID:30917979 PMID:34013864 Ngon_23S_AZM An OXA-12-family class D beta-lactamase identified from Aeromonas hydrophila. Aeromonas ampH OXA-724 antibiotic_resistance ARO:3004837 OXA-724 ARO:3004837 An OXA-12-family class D beta-lactamase identified from Aeromonas hydrophila. PMID:11062187 OXA-724 A class-A beta-lactamase from Klebsiella pneumoniae. LEN-30 antibiotic_resistance ARO:3004838 LEN-30 ARO:3004838 LEN-30 A class-A beta-lactamase from Klebsiella variicola. LEN-32 antibiotic_resistance ARO:3004839 LEN-32 ARO:3004839 LEN-32 A class-A beta-lactamase from Klebsiella variicola. LEN-34 antibiotic_resistance ARO:3004840 LEN-34 ARO:3004840 LEN-34 A class-A beta-lactamase from Klebsiella. LEN-38 antibiotic_resistance ARO:3004841 LEN-38 ARO:3004841 LEN-38 A class-A broad-spectrum beta-lactamase identified from Klebsiella sp. LEN-39 antibiotic_resistance ARO:3004842 LEN-39 ARO:3004842 LEN-39 A class-A broad-spectrum beta-lactamase identified from Klebsiella sp. LEN-40 antibiotic_resistance ARO:3004843 LEN-40 ARO:3004843 LEN-40 A class-A broad-spectrum beta-lactamase identified from Klebsiella. LEN-41 antibiotic_resistance ARO:3004844 LEN-41 ARO:3004844 LEN-41 A class-A broad-spectrum beta-lactamase from Klebsiella. LEN-42 antibiotic_resistance ARO:3004845 LEN-42 ARO:3004845 LEN-42 A class-A broad-spectrum beta-lactamase from Klebsiella. LEN-43 antibiotic_resistance ARO:3004846 LEN-43 ARO:3004846 LEN-43 A class-A broad-spectrum beta-lactamase from Klebsiella. LEN-51 antibiotic_resistance ARO:3004847 LEN-51 ARO:3004847 LEN-51 A class-A broad-spectrum beta-lactamase from Klebsiella. LEN-55 antibiotic_resistance ARO:3004848 LEN-55 ARO:3004848 LEN-55 A class-A broad-spectrum beta-lactamase from Klebsiella. LEN-58 antibiotic_resistance ARO:3004849 LEN-58 ARO:3004849 LEN-58 MtrR is a repressor of mtrCDE efflux pump expression, point mutations in mtrR confer resistance to azithromycin and other drugs. Ngon_mtrR_AZM antibiotic_resistance ARO:3004851 Neisseria gonorrhoeae mtrR with mutation conferring resistance ARO:3004851 MtrR is a repressor of mtrCDE efflux pump expression, point mutations in mtrR confer resistance to azithromycin and other drugs. PMID:10508026 PMID:18761689 Ngon_mtrR_AZM An experimental serine beta-lactamase inhibitor comparable to clavulanic acid, tazobactam and sulbactam. PubChem:23676494 antibiotic_resistance ARO:3004852 SYN-1012 ARO:3004852 Point mutations in the 3' domain of 16S rRNA of Mycobacterium tuberculosis can confer resistance to capreomycin. Mtub_16S_CAP rrs antibiotic_resistance ARO:3004853 Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to capreomycin ARO:3004853 Point mutations in the 3' domain of 16S rRNA of Mycobacterium tuberculosis can confer resistance to capreomycin. ISBN:978-92-4-008241-0 PMID:24953243 PMID:30337678 PMID:35944069 Mtub_16S_CAP A CMY-2-like beta-lactamase which confers resistance to cephalosporin antibiotics, and is also capable of hydrolyzing the CMY-2 inhibitors ticarcillin and cloxacillin. CMY-136 antibiotic_resistance ARO:3004854 CMY-136 ARO:3004854 A CMY-2-like beta-lactamase which confers resistance to cephalosporin antibiotics, and is also capable of hydrolyzing the CMY-2 inhibitors ticarcillin and cloxacillin. PMID:30788955 CMY-136 SCOs are Class A beta-lactamases that confer resistance to a narrow range of penams, with some minor activity on cephalosporins and carbapenems. antibiotic_resistance ARO:3004855 SCO beta-lactamase ARO:3004855 SCOs are Class A beta-lactamases that confer resistance to a narrow range of penams, with some minor activity on cephalosporins and carbapenems. PMID:17353248 PMID:17420213 PMID:20956594 Narrow-spectrum beta-lactamase isolated from several Acinetobacter spp. isolates from Argentina, as well as E. Coli. Hydrolyzes penicillins at a high level and cephalosporins and carbapenems at a very low level. A1E3K9 SCO-1 blaSCO-1 antibiotic_resistance ARO:3004856 SCO-1 ARO:3004856 Narrow-spectrum beta-lactamase isolated from several Acinetobacter spp. isolates from Argentina, as well as E. Coli. Hydrolyzes penicillins at a high level and cephalosporins and carbapenems at a very low level. PMID:17353248 PMID:17420213 PMID:20956594 SCO-1 Experimental antibiotic in phase two trial for Neisseria gonorrhoeae treatment. ChEMBL:CHEMBL3544978 PubChem:76685216 antibiotic_resistance ARO:3004858 Zoliflodacin ARO:3004858 Experimental antibiotic in phase two trial for Neisseria gonorrhoeae treatment. PMID:31730160 Point mutation in Neisseria gonorrhoea gyrase B decreases affinity to zoliflodacin antibiotic. Ngon_gyrB_ZOL antibiotic_resistance ARO:3004859 Neisseria gonorrhoeae gyrB conferring resistance to zoliflodacin ARO:3004859 Point mutation in Neisseria gonorrhoea gyrase B decreases affinity to zoliflodacin antibiotic. PMID:31730160 Ngon_gyrB_ZOL Point mutations in Burkholderia gyrA that confer resistance to ciprofloxacin, a fluoroquinolone antibiotic. Bdol_gyrA_FLO antibiotic_resistance ARO:3004860 Burkholderia dolosa gyrA conferring resistance to fluoroquinolones ARO:3004860 Point mutations in Burkholderia gyrA that confer resistance to ciprofloxacin, a fluoroquinolone antibiotic. PMID:25153194 PMID:25931592 Bdol_gyrA_FLO A class B New Delhi metallo-beta-lactamase and NDM-1 variant. NDM-18 antibiotic_resistance ARO:3004861 NDM-18 ARO:3004861 NDM-18 A class B New Delhi metallo-beta-lactamase and NDM-1 variant. NDM-19 antibiotic_resistance ARO:3004862 NDM-19 ARO:3004862 NDM-19 A class B New Delhi metallo-beta-lactamase. NDM-20 antibiotic_resistance ARO:3004863 NDM-20 ARO:3004863 NDM-20 A class B New Delhi metallo-beta-lactamase and NDM-1 variant. NDM-21 antibiotic_resistance ARO:3004864 NDM-21 ARO:3004864 NDM-21 A class B New Delhi metallo-beta-lactamase and NDM-1 variant. NDM-22 antibiotic_resistance ARO:3004865 NDM-22 ARO:3004865 NDM-22 A class B New Delhi metallo-beta-lactamase. NDM-23 antibiotic_resistance ARO:3004866 NDM-23 ARO:3004866 NDM-23 A class B New Delhi metallo-beta-lactamase. NDM-24 antibiotic_resistance ARO:3004867 NDM-24 ARO:3004867 NDM-24 A class B New Delhi metallo-beta-lactamase. NDM-25 antibiotic_resistance ARO:3004868 NDM-25 ARO:3004868 NDM-25 A class B New Delhi metallo-beta-lactamase and NDM-1 variant. NDM-26 antibiotic_resistance ARO:3004869 NDM-26 ARO:3004869 NDM-26 A class B New Delhi metallo-beta-lactamase and NDM-1 variant. NDM-27 antibiotic_resistance ARO:3004870 NDM-27 ARO:3004870 NDM-27 A class B New Delhi metallo-beta-lactamase and NDM-1 variant. NDM-28 antibiotic_resistance ARO:3004871 NDM-28 ARO:3004871 NDM-28 Point mutations in Neisseria gonorrhoeae dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance. Ngon_folP_SLF antibiotic_resistance ARO:3004873 Neisseria gonorrhoeae folP with mutation conferring resistance to sulfonamides ARO:3004873 Point mutations in Neisseria gonorrhoeae dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance. PMID:31358980 Ngon_folP_SLF Genes with mutations in inhA which confer resistance to isoniazid class antibiotics. antibiotic_resistance ARO:3004874 isoniazid resistant inhA ARO:3004874 Genes with mutations in inhA which confer resistance to ethionamide class antibiotics. antibiotic_resistance ARO:3004875 inhA with mutations with conferring resistance to ethionamide ARO:3004875 inhA is a enoyl-acyl carrier reductase used in lipid metabolism and farry acid biosynthesis. It is inhibited by ethionamide. Mutations in the promoter region or multiple copies of the inhA show marked resistance to ethionamide mediated inhibition of mycolic acid biosynthesis. Mtub_inhA_ETO Rv1484 antibiotic_resistance ARO:3004876 Mycobacterium tuberculosis inhA mutations conferring resistance to ethionamide ARO:3004876 inhA is a enoyl-acyl carrier reductase used in lipid metabolism and farry acid biosynthesis. It is inhibited by ethionamide. Mutations in the promoter region or multiple copies of the inhA show marked resistance to ethionamide mediated inhibition of mycolic acid biosynthesis. ISBN:978-92-4-008241-0 PMID:14623976 PMID:19581462 PMID:25568071 PMID:30337678 Mtub_inhA_ETO Mutations that occur in the clp protease subunit clpC1 that increases resistance to antibiotics. antibiotic_resistance ARO:3004877 antibiotic resistant clpC1 ARO:3004877 clpC1 is a subunit of the clp protease that is ATP-dependent. It functions to direct the clp protease to specific substrates. In the presence of ATP it hydrolyses proteins and may be involved in the degradation of denatured proteins. antibiotic_resistance ARO:3004878 pyrazinamide resistant clpC1 ARO:3004878 Mutations that occur in gpsI that increases resistance to antibiotics. antibiotic_resistance ARO:3004879 antibiotic resistant gpsI ARO:3004879 gpsI codes for polyribonucleotide nucleotidyltransferase which is a protein involved in mRNA degradation. It catalyzes the phosphorolysis of single-stranded polyribonucleotides in the 3'- to 5'-direction. antibiotic_resistance ARO:3004880 pyrazinamide resistant gpsI ARO:3004880 Mutations that occur in the mas that increases resistance to antibiotics. antibiotic_resistance ARO:3004881 antibiotic resistant mas ARO:3004881 Mas is a multifunctional mycocerosic acid synthase membrane-associated mas. It catalyzes the elongation of N-fatty acyl-CoA with methylamalonyl-CoA as the elongating agent to form mycocerosyl fatty acids present in mycobacterium. antibiotic_resistance ARO:3004882 pyrazinamide resistant mas ARO:3004882 Mutations that occur in the ppsC that increases resistance to antibiotics. antibiotic_resistance ARO:3004883 antibiotic resistant ppsC ARO:3004883 ppsC codes for the phthiocerol synthesis polyketide synthase type 1. It is involved in the elongation of C22-24 fatty acids by the addition of methylmalonyl-CoA extender units to yield phthiocerol derivatives in a complete reduction. Research has pointed towards this protein to be a high confidence drug target. antibiotic_resistance ARO:3004884 pyrazinamide resistant ppsC ARO:3004884 Mutations that occur in the ppsD that increases resistance to antibiotics. antibiotic_resistance ARO:3004885 antibiotic resistant ppsD ARO:3004885 ppsD codes for the phthiocerol synthesis polyketide synthase type 1. It is involved in the elongation of C22-24 fatty acids by the addition of malonyl-CoA extender units to yield phthiocerol derivatives in a partial reduction. antibiotic_resistance ARO:3004886 pyrazinamide resistant ppsD ARO:3004886 Mutations that occur in the fabg1 gene resulting in the inability for the antibiotic to inhibit mycolic acid biosynthesis. antibiotic_resistance ARO:3004887 antibiotic resistant fabG1 ARO:3004887 fabG1 is involved in the fatty acid synthesis pathway, acting in the first reduction step for mycolic acid. It is associated with ethionamide resistance. antibiotic_resistance ARO:3004888 ethionamide resistant fabG1 ARO:3004888 Mutations that occur on the mshC gene resulting in the inability for antibiotic to function. antibiotic_resistance ARO:3004889 antibiotic resistant mshC ARO:3004889 Mutations that occur in mshC which is involved in the third step of mycothiol biosynthesis. It catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins. The gene exhibits resistance to ethionamide. antibiotic_resistance ARO:3004890 ethionamide resistant mshC ARO:3004890 Mutations that occur on the nudC gene resulting in the inability for antibiotic to function. antibiotic_resistance ARO:3004891 antibiotic resistant nudC ARO:3004891 nudC is a NADH pyrophosphatase that is involved in nicotinate and nicotinamide metabolism. Mutations that occur on the nudC gene resulting in the inability for ethionamide to function. antibiotic_resistance ARO:3004892 ethionamide resistant nudC ARO:3004892 Mutations in ahpC that contribute to antibiotic resistance by preventing ahpC from activating antibiotics. antibiotic_resistance ARO:3004893 antibiotic resistant ahpC ARO:3004893 An alkyl hydroperoxide reductase that catalyzes the reduction of organic hydrogen peroxide to water and organic alcohols. Plays a role in protecting oxidative stress. antibiotic_resistance ARO:3004894 Isoniazid resistant ahpC ARO:3004894 fabG1 is involved in the fatty acid synthesis pathway, acting in the first reduction step for mycolic acid. It is associated with isoniazid resistance. antibiotic_resistance ARO:3004895 isoniazid resistant fabG1 ARO:3004895 Mutations that occur in furA which is in the regulatory region of katG. Mutations within the gene contribute to antibiotic resistance. antibiotic_resistance ARO:3004896 antibiotic resistant furA ARO:3004896 Transcriptional regulator furA, represses the transcription of the catalase-peroxidase gene katG and its own transcription by binding to the promoter region. antibiotic_resistance ARO:3004897 isoniazid resistant furA ARO:3004897 Mutations in inbR that contribute to antibiotic resistance by preventing antibiotic activation. antibiotic_resistance ARO:3004898 antibiotic resistant inbR ARO:3004898 inbR is part of the transcriptional factor family TetR. It acts as a repressor to regulate efflux pumps involved in antibiotic resistance. Rv0275c antibiotic_resistance ARO:3004899 isoniazid resistant inbR ARO:3004899 Mutations that occur in the mshA gene resulting in the inability for antibiotic to activate. antibiotic_resistance ARO:3004900 antibiotic resistant mshA ARO:3004900 mshA is a glycosyltransferase and is involved in the first step of mycothiol biosynthesis. This is a step that is required for growth in mycobacterium tuberculosis. Resistance has been shown in the gene to isoniazid. antibiotic_resistance ARO:3004901 isoniazid resistant mshA ARO:3004901 Mutations that occur in the mshB gene that results in antibiotic resistance. antibiotic_resistance ARO:3004902 antibiotic resistant mshB ARO:3004902 mshB is a deacetylase that is involved in the second step of mycothiol synthesis. GlcNAc-Ins is deacetylated by MshB to produce GlcN-Ins. antibiotic_resistance ARO:3004903 isoniazid resistant mshB ARO:3004903 Mutations that occur on the mshC gene resulting in the inability for isoniazid to function. It catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins. antibiotic_resistance ARO:3004904 isoniazid resistant mshC ARO:3004904 Mutations that occur within the coding region of mymA that prevent effective antibiotic function. antibiotic_resistance ARO:3004905 antibiotic resistant mymA ARO:3004905 mymA is an operon that begins at Rv3083 and ends at Rv3089 and is required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. It has shown to be resistant to isoniazid. antibiotic_resistance ARO:3004906 isoniazid resistant mymA ARO:3004906 Mutations that occur in mmaA3 which decreases effective functioning of antibiotics. antibiotic_resistance ARO:3004907 antibiotic resistant mmaA3 ARO:3004907 Methoxy mycolic acid synthase 3 is involved in the modification of mycolic acids. It represents a major part of the mycobacterial cell wall complex. antibiotic_resistance ARO:3004908 isoniazid resistant mmaA3 ARO:3004908 Mutations that occur in nat inactivate antibiotic functioning and contribute to antibiotic resistance. antibiotic_resistance ARO:3004909 Antibiotic resistant nat ARO:3004909 Arylamine N-acetyltransferase catalyzes the transfer of the acetyl group from acetyl coenzyme A to the free amino group of arylamines and hydrazines. Reports have shown that overexpression of this enzyme may be responsible for increased resistance to isoniazid. antibiotic_resistance ARO:3004910 isoniazid resistant nat ARO:3004910 nudC is a NADH pyrophosphatase that is involved in nicotinate and nicotinamide metabolism. Mutations that occur on the nudC gene resulting in the inability for isoniazid to function. antibiotic_resistance ARO:3004911 isoniazid resistant nudC ARO:3004911 Mutations that occur in SigI sigma factor that increase resistance to antibiotics. antibiotic_resistance ARO:3004912 antibiotic resistant sigI ARO:3004912 A sigma factor that acts as an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released. Transcriptional analyses indicate that katG is also regulated by the sigma factor sigl and indicate resistance to isoniaizd. antibiotic_resistance ARO:3004913 isoniazid resistant sigI ARO:3004913 ESX-5 secretion system is are important for virulence of mycobacteria and is required for mycobacterial cell wall stability and host cell lysis. The system is comprised of genes that encode the structural components of the secretion system. The system secrets mycobacterial proteins involved in virulence and pathogenicity and important for mycobacterium viability. Resistance has been shown to specific antibiotics. antibiotic_resistance ARO:3004915 fluoroquinolone-resistant ESX5 secretion system ARO:3004915 Subunits of the secretion system complex that secretes proteins that contribute to resistance. antibiotic_resistance ARO:3004916 subunits of secretion system conferring antibiotic resistance ARO:3004916 Mutations in the eccB5 gene contributing to antibiotic resistance to fluoroquinolone. antibiotic_resistance ARO:3004917 fluoroquinolone resistant eccB5 ARO:3004917 eccB5 is a transmembrane protein within the ESX-5 secretion system complex. The complex is critical for mycobacterium viability and virulence in the host cell and mutations contribute to a decreased uptake of antibiotic in the outer membrane. Mtub_eccB5_FLO antibiotic_resistance ARO:3004918 Mycobacterium tuberculosis eccB5 conferring resistance to fluoroquinolones ARO:3004918 eccB5 is a transmembrane protein within the ESX-5 secretion system complex. The complex is critical for mycobacterium viability and virulence in the host cell and mutations contribute to a decreased uptake of antibiotic in the outer membrane. PMID:30337678 PMID:34161790 Mtub_eccB5_FLO eccC5 is a membrane-bound ATPase within the ESX-5 secretion system complex. The complex is critical for mycobacterium viability and virulence in the host cell and mutations contribute to a decreased uptake of antibiotic in the outer membrane, yet the Relational Sequencing Tuberculosis Data platform (ReSeqTB, https://platform.reseqtb.org) finds no evidence of an association between eccC5 mutations and drug resistance. Mtub_eccC5_FLO antibiotic_resistance ARO:3004919 Mycobacterium tuberculosis eccC5 conferring resistance to fluoroquinolones ARO:3004919 eccC5 is a membrane-bound ATPase within the ESX-5 secretion system complex. The complex is critical for mycobacterium viability and virulence in the host cell and mutations contribute to a decreased uptake of antibiotic in the outer membrane, yet the Relational Sequencing Tuberculosis Data platform (ReSeqTB, https://platform.reseqtb.org) finds no evidence of an association between eccC5 mutations and drug resistance. PMID:30337678 Mtub_eccC5_FLO Mutations in the eccC5 gene contributing to antibiotic resistance to fluoroquinolone. antibiotic_resistance ARO:3004920 fluoroquinolone resistant eccC5 ARO:3004920 Mutations that occur in ahpC that result in ahpC overexpression thus conferring or contributing to resistance to isoniazid. Mtub_ahpC_INH Rv2428 antibiotic_resistance ARO:3004921 Mycobacterium tuberculosis ahpC mutations confer resistance to isoniazid ARO:3004921 Mutations that occur in ahpC that result in ahpC overexpression thus conferring or contributing to resistance to isoniazid. PMID:30337678 PMID:35944069 PMID:8830260 Mtub_ahpC_INH Mutations that occur in fabG1 resulting in or contributing to resistance in isoniazid. Mtub_fabG1_INH Rv1483 antibiotic_resistance ARO:3004922 Mycobacterium tuberculosis fabG1 mutations confer resistance to isoniazid ARO:3004922 Mutations that occur in fabG1 resulting in or contributing to resistance in isoniazid. ISBN:978-92-4-008241-0 PMID:16189082 PMID:30337678 PMID:35944069 Mtub_fabG1_INH Mutations that occur in furA that result in or contribute to antibiotic resistance to isoniazid. Mtub_furA_INH Rv1909c antibiotic_resistance ARO:3004923 Mycobacterium tuberculosis furA mutations confer resistance to isoniazid ARO:3004923 Mutations that occur in furA that result in or contribute to antibiotic resistance to isoniazid. PMID:24055765 PMID:25092698 PMID:30337678 Mtub_furA_INH Mutations that occur in inbR that result in or contribute to antibiotic resistance to isoniazid. Mtub_inbR_INH Rv0275c antibiotic_resistance ARO:3004924 Mycobacterium tuberculosis inbR mutations conferring resistance to isoniazid ARO:3004924 Mutations that occur in inbR that result in or contribute to antibiotic resistance to isoniazid. PMID:26353937 PMID:30337678 Mtub_inbR_INH Mutations that occur in Mycobacterium tuberculosis mshA that result in or contribute to antibiotic resistance to isoniazid. Mtub_mshA_INH Rv0486 antibiotic_resistance ARO:3004925 Mycobacterium tuberculosis mshA mutations conferring resistance to isoniazid ARO:3004925 Mutations that occur in Mycobacterium tuberculosis mshA that result in or contribute to antibiotic resistance to isoniazid. PMID:30337678 PMID:30583053 Mtub_mshA_INH Mutations that occur in mshC that result in or contribute to antibiotic resistance to isoniazid. Mtub_mshC_INH Rv2130c antibiotic_resistance ARO:3004927 Mycobacterium tuberculosis mshC mutations conferring resistance to isoniazid ARO:3004927 Mutations that occur in mshC that result in or contribute to antibiotic resistance to isoniazid. PMID:26104204 PMID:30337678 Mtub_mshC_INH Mutations that occur in the mymA operon that result in or contribute to antibiotic resistance to isoniazid. Mtub_mymA_INH Rv3083 antibiotic_resistance ARO:3004928 Mycobacterium tuberculosis mymA mutations conferring resistance to isoniazid ARO:3004928 Mutations that occur in the mymA operon that result in or contribute to antibiotic resistance to isoniazid. PMID:30082293 PMID:30337678 Mtub_mymA_INH Mutations that occur in mmaA3 that result in or contribute to antibiotic resistance to isoniazid. Mtub_mmaA3_INH Rv0643c antibiotic_resistance ARO:3004929 Mycobacterium tuberculosis mmaA3 mutations conferring resistance to isoniazid ARO:3004929 Mutations that occur in mmaA3 that result in or contribute to antibiotic resistance to isoniazid. PMID:21426023 PMID:30337678 PMID:33055230 Mtub_mmaA3_INH Mutations that occur in nat which through overexpression of the enzyme can result in or contribute to antibiotic resistance to isoniazid. Mtub_nat_INH Rv3566c antibiotic_resistance ARO:3004930 Mycobacterium tuberculosis nat mutations conferring resistance to isoniazid ARO:3004930 Mutations that occur in nat which through overexpression of the enzyme can result in or contribute to antibiotic resistance to isoniazid. PMID:26104204 PMID:30337678 Mtub_nat_INH Mutations that occur in nudC which through overexpression of the enzyme can result in or contribute to antibiotic resistance to isoniazid. Mtub_nudC_INH Rv3199c antibiotic_resistance ARO:3004931 Mycobacterium tuberculosis nudC mutations conferring resistance to isoniazid ARO:3004931 Mutations that occur in nudC which through overexpression of the enzyme can result in or contribute to antibiotic resistance to isoniazid. PMID:26104204 PMID:30337678 Mtub_nudC_INH Mycobacterium tuberculosis sigI mutations conferring resistance to isoniazid. Mtub_sigI_INH Rv0735 antibiotic_resistance ARO:3004932 Mycobacterium tuberculosis sigI mutations conferring resistance to isoniazid ARO:3004932 Mycobacterium tuberculosis sigI mutations conferring resistance to isoniazid. PMID:26104204 PMID:30337678 Mtub_sigI_INH Mutations that occur in Mycobacterium tuberculosis fabG1 resulting in or contributing to resistance in ethionamide. Mtub_fabG1_ETO Rv1483 antibiotic_resistance ARO:3004933 Mycobacterium tuberculosis fabG1 mutation conferring resistance to ethionamide ARO:3004933 Mutations that occur in Mycobacterium tuberculosis fabG1 resulting in or contributing to resistance in ethionamide. ISBN:978-92-4-008241-0 PMID:16189082 PMID:30337678 PMID:35944069 Mtub_fabG1_ETO Mutations that occur in mshC resulting in or contributing to conferring resistance to ethionamide. Mtub_mshC_ETO Rv2130c antibiotic_resistance ARO:3004934 Mycobacterium tuberculosis mshC mutations conferring resistance to ethionamide ARO:3004934 Mutations that occur in mshC resulting in or contributing to conferring resistance to ethionamide. PMID:26104204 PMID:30337678 Mtub_mshC_ETO Mutations that occur in nudC resulting in or contributing to conferring resistance to ethionamide. Mtub_nudC_ETO Rv3199c antibiotic_resistance ARO:3004935 Mycobacterium tuberculosis nudC mutations conferring resistance to ethionamide ARO:3004935 Mutations that occur in nudC resulting in or contributing to conferring resistance to ethionamide. PMID:26104204 PMID:30337678 Mtub_nudC_ETO Point mutations in the 23S rRNA of bacteria can confer resistance to aminoglycosides. antibiotic_resistance ARO:3004936 23s rRNA with mutation conferring resistance to aminoglycoside antibiotics ARO:3004936 Point mutations in 23S rRNA of Mycobacterium tuberculosis can confer resistance to capreomycin. Mtub_23S_CAP rrl antibiotic_resistance ARO:3004937 Mycobacterium tuberculosis 23S rRNA mutation conferring resistance to capreomycin ARO:3004937 Point mutations in 23S rRNA of Mycobacterium tuberculosis can confer resistance to capreomycin. PMID:16857584 PMID:30337678 Mtub_23S_CAP Mutations in the D-alanine synthase of Mycobacterium tuberculosis can confer resistance to antibiotics. antibiotic_resistance ARO:3004938 antibiotic resistant ddlA ARO:3004938 ddlA catalyzes the ATP-driven ligation of two D-alanine molecules to form the D-alanyl-D-alanine dipeptide, key in forming the cell wall. Cycloserine has a similar structure to d-alanine and inhibits the growth of the cell wall. antibiotic_resistance ARO:3004939 cycloserine resistant ddlA ARO:3004939 Point mutations that occur within Mycobacterium tuberculosis ddlA gene resulting in resistance to cycloserine. Mtub_ddlA_DCS antibiotic_resistance ARO:3004941 Mycobacterium tuberculosis ddlA mutations confer resistance to cycloserine ARO:3004941 Point mutations that occur within Mycobacterium tuberculosis ddlA gene resulting in resistance to cycloserine. PMID:28231674 PMID:30337678 Mtub_ddlA_DCS Mutations that occur in ald which decreases effective functioning of antibiotics. antibiotic_resistance ARO:3004942 antibiotic resistant ald ARO:3004942 ald plays a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer. Resistance due to mutations in ald can cause cycloserine to not function. antibiotic_resistance ARO:3004943 cycloserine resistant ald ARO:3004943 Mutations that occur in alr which decreases effective functioning of antibiotics. antibiotic_resistance ARO:3004944 antibiotic resistant alr ARO:3004944 Mutations in the ald gene that contribute to or confer resistance to cycloserine. Mtub_ald_DCS antibiotic_resistance ARO:3004945 Mycobacterium tuberculosis ald mutations confer resistance to cycloserine ARO:3004945 Mutations in the ald gene that contribute to or confer resistance to cycloserine. PMID:27064254 PMID:30337678 Mtub_ald_DCS Provides the D-alanine required for cell wall biosynthesis. Transforms L-alanine to D-alanine. Can confer resistance to cycloserine. antibiotic_resistance ARO:3004946 cycloserine resistant alr ARO:3004946 Mutations in the alr mutation contribute to or confer resistance to cycloserine. Mtub_alr_DCS antibiotic_resistance ARO:3004947 Mycobacterium tuberculosis alr with mutation conferring resistance to cycloserine ARO:3004947 Mutations in the alr mutation contribute to or confer resistance to cycloserine. PMID:28971867 PMID:30337678 Mtub_alr_DCS Decaprenylphosphoryl-5-phosphoribose (DPPR) synthase involved in arabinogalactan synthesis. antibiotic_resistance ARO:3004948 antibiotic resistant ubiA ARO:3004948 DDPR synthase involved in arabinogalactan synthesis. Mutations can confer resistance to ethambutol. antibiotic_resistance ARO:3004949 ethambutol resistant ubiA ARO:3004949 Mutations in the ubiA gene contribute to or confer resistance to ethambutol. Mtub_ubiA_EMB Rv3806c antibiotic_resistance ARO:3004950 Mycobacterium tuberculosis ubiA mutations confer resistance to ethambutol ARO:3004950 Mutations in the ubiA gene contribute to or confer resistance to ethambutol. PMID:30337678 PMID:30711156 Mtub_ubiA_EMB Mutations in aftA gene contribute to or confer resistance to ethamutol. Mtub_aftA_EMB Rv3792 antibiotic_resistance ARO:3004951 Mycobacterium tuberculosis aftA mutations confer resistance to ethambutol ARO:3004951 Mutations in aftA gene contribute to or confer resistance to ethamutol. PMID:23995136 PMID:29084750 PMID:30337678 Mtub_aftA_EMB Thioacetazone is an inexpensive, antitubercular, bacteriostatic drug that has been widely used in combination with isoniazid in Africa and South America. This drug is rarely in use. CAS:104-06-3 ChEBI:134958 ChEMBL:CHEMBL375492 PubChem:9568512 amithiozone thiacetazone antibiotic_resistance ARO:3004952 thioacetazone ARO:3004952 Thioacetazone is an inexpensive, antitubercular, bacteriostatic drug that has been widely used in combination with isoniazid in Africa and South America. This drug is rarely in use. PMID:18094751 Rv0565c is a bacterial monoxygenase that has been newly uncovered in recent literature to show resistance to antibiotic. antibiotic_resistance ARO:3004953 antibiotic resistant Rv0565c ARO:3004953 Mycobacterial monoxygenase has been shown to confer resistance to ethionamide in recent literature. antibiotic_resistance ARO:3004954 Ethionamide resistant Rv0565c ARO:3004954 Mutations in a bacterial monooxygenase, Rv0565c, are significantly associated with ethionamide resistance as an activator of ethionamide. Mtub_Rv0565_ETO Rv0565c antibiotic_resistance ARO:3004955 Mycobacterium tuberculosis Rv0565c mutation conferring resistance to ethionamide ARO:3004955 Mutations in a bacterial monooxygenase, Rv0565c, are significantly associated with ethionamide resistance as an activator of ethionamide. PMID:30337678 PMID:31015328 Mtub_Rv0565_ETO rpld encodes for the 50S L4 ribosomal protein, is a macrolide resistance protein identified in Neisseria gonorrhoeae. Ngon_rpld antibiotic_resistance ARO:3004956 Neisseria gonorrhoeae rpld ARO:3004956 rpld encodes for the 50S L4 ribosomal protein, is a macrolide resistance protein identified in Neisseria gonorrhoeae. PMID:26935729 PMID:27638945 Ngon_rpld Mutations that occur in clpC1 that result in or contribute to antibiotic resistance to pyrazinamide. Mtub_clpC1_PZA antibiotic_resistance ARO:3004957 Mycobacterium tuberculosis clpC1 with mutation conferring resistance to pyrazinamide ARO:3004957 Mutations that occur in clpC1 that result in or contribute to antibiotic resistance to pyrazinamide. PMID:28271875 PMID:30337678 PMID:33722890 Mtub_clpC1_PZA A probable bifunctional penicillin-binding protein that is involved in the final stages of peptidoglycan synthesis. It has been shown to cause resistance to antibiotics. antibiotic_resistance ARO:3004958 antibiotic resistant ponA1 ARO:3004958 Mutations in the ponA1 gene that can contribute to or confer resistance to rifamycin-class antibiotics. antibiotic_resistance ARO:3004959 rifamycin resistant ponA1 ARO:3004959 Mutations in ponA1 that contribute to or confer resistance to rifabutin antibiotic. Mtub_ponA1_RFB Rv0050 antibiotic_resistance ARO:3004960 Mycobacterium tuberculosis ponA1 mutations conferring resistance to rifabutin ARO:3004960 Mutations in ponA1 that contribute to or confer resistance to rifabutin antibiotic. PMID:23995135 PMID:24962424 PMID:30337678 Mtub_ponA1_RFB Mutations in the eis gene that can contribute to antibiotic resistance. antibiotic_resistance ARO:3004961 antibiotic resistant eis ARO:3004961 Involved in acetylation and intracellular survival. Associated with the cell surface and secretion proteins. antibiotic_resistance ARO:3004962 kanamycin resistant eis ARO:3004962 Mutations in eis that contribute to or confer resistance to kanamycin. Mtub_eis_KAN antibiotic_resistance ARO:3004963 Mycobacterium tuberculosis eis mutations confer resistance to kanamycin ARO:3004963 Mutations in eis that contribute to or confer resistance to kanamycin. ISBN:978-92-4-008241-0 PMID:19906990 PMID:30337678 PMID:35944069 Mtub_eis_KAN Mutations in the whib7 gene that cause antibiotic resistance. antibiotic_resistance ARO:3004964 antibiotic resistant whib7 ARO:3004964 A protein involved in transcriptional mechanisms. Mutations in the gene can cause resistance to streptomycin. antibiotic_resistance ARO:3004965 streptomycin resistant whib7 ARO:3004965 whib7 is a protein involved in transcriptional mechanisms. Mutations in the gene can cause resistance to kanamycin. antibiotic_resistance ARO:3004966 Kanamycin resistant whib7 ARO:3004966 Mutations in whib7 that can contribute to or confer resistance to kanamycin. Mtub_whib7_KAN Rv3197A antibiotic_resistance ARO:3004967 Mycobacterium tuberculosis whib7 mutations confer resistance to kanamycin ARO:3004967 Mutations in whib7 that can contribute to or confer resistance to kanamycin. PMID:23380727 PMID:30337678 Mtub_whib7_KAN Mutations in whib7 that can contribute to or confer resistance to streptomycin. Mtub_whib7_STR Rv3197A whmC antibiotic_resistance ARO:3004968 Mycobacterium tuberculosis whib7 mutation conferring resistance to streptomycin ARO:3004968 Mutations in whib7 that can contribute to or confer resistance to streptomycin. PMID:23380727 PMID:30337678 Mtub_whib7_STR An efflux pump in mycobacterium that contributes to intrinsic antibiotic resistance. The pump uses the electrochemical gradient as a source of energy. antibiotic_resistance ARO:3004970 streptomycin resistant Rv1258c ARO:3004970 Mutations in the Rv1258c (Tap) gene that can contribute to or confer resistance to streptomycin. Mtub_tap_STR Rv1258c antibiotic_resistance ARO:3004971 Mycobacterium tuberculosis Rv1258c mutations confer resistance to streptomycin ARO:3004971 Mutations in the Rv1258c (Tap) gene that can contribute to or confer resistance to streptomycin. PMID:30337678 PMID:30837962 Mtub_tap_STR Mutations in ppsA can result in antibiotic resistance. antibiotic_resistance ARO:3004972 antibiotic resistant ppsA ARO:3004972 Involved in the elongation of either C22-24 fatty acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield phthiocerol derivatives. Mutations in the gene may confer resistance to pyrazinamide. antibiotic_resistance ARO:3004973 pyrazinamide resistant ppsA ARO:3004973 Mutations in ppsC can contribute to or confer resistance to pyrazinamide. Mtub_ppsC_PZA Rv2933 antibiotic_resistance ARO:3004975 Mycobacterium tuberculosis ppsC mutations confer resistance to pyrazinamide ARO:3004975 Mutations in ppsC can contribute to or confer resistance to pyrazinamide. PMID:29686155 PMID:30337678 Mtub_ppsC_PZA Mutations in ppsD can contribute to or confer resistance to pyrazinamide. Mtub_ppsD_PZA Rv2934 antibiotic_resistance ARO:3004976 Mycobacterium tuberculosis ppsD mutations confer resistance to pyrazinamide ARO:3004976 Mutations in ppsD can contribute to or confer resistance to pyrazinamide. PMID:30333483 PMID:30337678 Mtub_ppsD_PZA Mutations in gpsI that can contribute to or confer resistance to pyrazinamide. Mtub_gpsI_PZA Rv2783c antibiotic_resistance ARO:3004977 Mycobacterium tuberculosis gpsI with mutations conferring resistance to pyrazinamide ARO:3004977 Mutations in gpsI that can contribute to or confer resistance to pyrazinamide. PMID:29020922 PMID:30337678 Mtub_gpsI_PZA Mutations in mas that can contribute to or confer resistance to pyrazinamide. Mtub_mas_PZA Rv2940c antibiotic_resistance ARO:3004978 Mycobacterium tuberculosis mas mutations confer resistance to pyrazinamide ARO:3004978 Mutations in mas that can contribute to or confer resistance to pyrazinamide. PMID:27759369 PMID:30337678 Mtub_mas_PZA Mutations in the gene can contribute to antibiotic resistance. Chloramphenicol efflux pump Rv0191 antibiotic_resistance ARO:3004979 antibiotic resistant Rv0191 ARO:3004979 A probable conserved integral membrane protein that acts as an active efflux pump. Overexpression causes pyrazinamide resistance. antibiotic_resistance ARO:3004980 pyrazinamide resistant Rv0191 ARO:3004980 Mutations in the Rv0191 gene contribute to or confer resistance to pyrazinamide. Mtub_Rv0191_PZA Rv0191 antibiotic_resistance ARO:3004981 Mycobacterium tuberculosis Rv0191 mutations confer resistance to pyrazinamide ARO:3004981 Mutations in the Rv0191 gene contribute to or confer resistance to pyrazinamide. PMID:28584158 PMID:30337678 Mtub_Rv0191_PZA Mutations in the Rv1667 gene can contribute or confer resistance to antibiotics. antibiotic_resistance ARO:3004982 antibiotic resistant Rv1667 ARO:3004982 A probable transport protein thought to be involved in the active transport of macrolide across the membrane in mycobacterium. antibiotic_resistance ARO:3004983 pyrazinamide resistant Rv1667 ARO:3004983 Mutations in the Rv1667 gene that can contribute to or confer resistance to pyrazinamide. Resistance may be due to an antibiotic export mechanism. Mtub_Rv1667_PZA Rv1667 antibiotic_resistance ARO:3004984 Mycobacterium tuberculosis Rv1667 mutations confer resistance to pyrazinamide ARO:3004984 Mutations in the Rv1667 gene that can contribute to or confer resistance to pyrazinamide. Resistance may be due to an antibiotic export mechanism. PMID:28584158 PMID:30337678 Mtub_Rv1667_PZA Mutations in the Rv2731 gene that contribute to antibiotic resistance. antibiotic_resistance ARO:3004985 antibiotic resistant Rv2731 ARO:3004985 A conserved alanine and arginine-rich protein with an unknown function. The protein has shown to contribute to or confer resistance to pyrazinamide. antibiotic_resistance ARO:3004986 pyrazinamide resistant Rv2731 ARO:3004986 Mutations in the Rv2731 gene that contribute to or confer resistance to pyrazinamide. Mtub_Rv2731_PZA Rv2731 antibiotic_resistance ARO:3004987 Mycobacterium tuberculosis Rv2731 mutations confer resistance to pyrazinamide ARO:3004987 Mutations in the Rv2731 gene that contribute to or confer resistance to pyrazinamide. PMID:29020922 PMID:30337678 Mtub_Rv2731_PZA Mutations in Rv3008 can contribute to or confer resistance to antibiotics. antibiotic_resistance ARO:3004988 antibiotic resistant Rv3008 ARO:3004988 A hypothetical protein for which it has been predicted but no experimental evidence exists to determine its function. May contribute to pyrazinamide resistance. antibiotic_resistance ARO:3004989 pyrazinamide resistant Rv3008 ARO:3004989 Mutations in the Rv3169 gene contribute to or confer resistance to antibiotics. antibiotic_resistance ARO:3004991 antibiotic resistant Rv3169 ARO:3004991 A conserved protein with an unknown function determined through proteomics study. May contribute or confer resistance to pyrazinamide resistance. antibiotic_resistance ARO:3004992 pyrazinamide resistant Rv3169 ARO:3004992 Mutations in the Rv3169 gene that can contribute to or confer resistance to pyrazinamide resistance. Mtub_Rv3169_PZA Rv3169 antibiotic_resistance ARO:3004993 Mycobacterium tuberculosis Rv3169 mutations confer resistance to pyrazinamide ARO:3004993 Mutations in the Rv3169 gene that can contribute to or confer resistance to pyrazinamide resistance. PMID:29020922 PMID:30337678 Mtub_Rv3169_PZA Mutations in rpoC that contribute to or confer resistance to rifampicin antibiotic. Mtub_rpoC_RIF Rv0668 antibiotic_resistance ARO:3004994 Mycobacterium tuberculosis rpoC mutations confer resistance to rifampicin ARO:3004994 Mutations in rpoC that contribute to or confer resistance to rifampicin antibiotic. PMID:23208709 PMID:30337678 Mtub_rpoC_RIF rpoC catalyzes the transcription of DNA into RNA and mutations confer resistance to rifampicin. antibiotic_resistance ARO:3004995 rifampicin resistant rpoC ARO:3004995 RNA polymerase is a multisubunit enzyme that is necessary for transcription. Catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. antibiotic_resistance ARO:3004996 antibiotic sensitive beta-prime subunit of RNA polymerase (rpoA) ARO:3004996 RNA polymerase is a multisubunit enzyme that is necessary for transcription. Mutations in rpoA gene confer antibiotic resistance. antibiotic_resistance ARO:3004997 antibiotic resistant rpoA ARO:3004997 rpoA catalyzes the transcription of DNA into RNA and mutations confer resistance to rifampicin. antibiotic_resistance ARO:3004998 rifampicin resistant rpoA ARO:3004998 Mutations in rpoA that contribute to or confer resistance to rifampicin antibiotic. Mtub_rpoA_RIF Rv3457c antibiotic_resistance ARO:3004999 Mycobacterium tuberculosis rpoA mutations confer resistance to rifampicin ARO:3004999 Mutations in rpoA that contribute to or confer resistance to rifampicin antibiotic. PMID:23208709 PMID:30337678 Mtub_rpoA_RIF Point mutations in DNA gyrase subunit B (gyrB) of Neisseria gonorrhoeae can result in resistance to Zoliflodacin. antibiotic_resistance ARO:3005000 Zoliflodacin resistant gyrB ARO:3005000 Nucleotide point mutations in the 50S rRNA subunit (not in the 23s rRNA range) may confer resistance to macrolide antibiotics. antibiotic_resistance ARO:3005001 50S rRNA with mutation conferring resistance to macrolide antibiotics ARO:3005001 Genes ppsA-E constitute an operon encoding enzymes involved in the biosynthesis of phthiocerol dimycocerosate and other lipids in Mycobacterium tuberculosis. Mutations within this region can result in resistance to pyrazinamide. antibiotic_resistance ARO:3005002 antibiotic resistant polyketide synthase genes ARO:3005002 Mutations in the prokaryotic 50S ribosomal RNA subunit which disrupt binding sites and thereby reduce antibiotic efficacy. antibiotic_resistance ARO:3005003 50S rRNA with mutation conferring antibiotic resistance ARO:3005003 Mutation in the mtrC efflux pump of Neisseria gonorrhoea shown to confer resistance to azithromycin, a macrolide type antibiotic. Ngon_mtrC_AZM antibiotic_resistance ARO:3005004 Neisseria gonorrhoeae mtrC with mutation conferring resistance to azithromycin ARO:3005004 Mutation in the mtrC efflux pump of Neisseria gonorrhoea shown to confer resistance to azithromycin, a macrolide type antibiotic. PMID:21933917 Ngon_mtrC_AZM Known antibiotic-resistant variants of emb arabinosyltransferases, primarily in Mycobacterium and conferring resistance to ethambutol through point mutation. antibiotic_resistance ARO:3005005 antibiotic-resistant emb arabinosyltransferase ARO:3005005 Known antibiotic-resistant variants of emb arabinosyltransferases, primarily in Mycobacterium and conferring resistance to ethambutol through point mutation. PMID:18174142 A tetracycline efflux MFS Transporter from Providencia sp. Y14. tet(57) antibiotic_resistance ARO:3005006 tet(57) ARO:3005006 A tetracycline efflux MFS Transporter from Providencia sp. Y14. PMID:11381101 tet(57) QnrVC2 is a class 1 integron found in Ciprofloxacin-resistant Vibro choleraeO1. QnrVC2 antibiotic_resistance ARO:3005007 QnrVC2 ARO:3005007 QnrVC2 is a class 1 integron found in Ciprofloxacin-resistant Vibro choleraeO1. PMID:18598639 QnrVC2 TxR is a putative transcription regulator that plays a role in conferring tetracycline resistance. It is required for proper functioning of Tet35. TxR antibiotic_resistance ARO:3005008 TxR ARO:3005008 TxR is a putative transcription regulator that plays a role in conferring tetracycline resistance. It is required for proper functioning of Tet35. PMID:11897587 TxR QacE is a resistance gene conferring resistance to antiseptics. qacE antibiotic_resistance ARO:3005009 qacE ARO:3005009 QacE is a resistance gene conferring resistance to antiseptics. PMID:10339831 qacE QacEdelta1 is a resistance gene conferring resistance to antiseptics. It is different from QacE only at the 3'-terminus. qacEdelta1 antibiotic_resistance ARO:3005010 qacEdelta1 ARO:3005010 QacEdelta1 is a resistance gene conferring resistance to antiseptics. It is different from QacE only at the 3'-terminus. PMID:10339831 qacEdelta1 IDC beta-lactamases are class C beta-lactamases inc. cephalosporinases and carbapenemases. antibiotic_resistance ARO:3005011 IDC beta-lactamase ARO:3005011 IDC beta-lactamases are class C beta-lactamases inc. cephalosporinases and carbapenemases. PMID:32183280 IDC-2 is an IDC beta-lactamase and an integron cephalosprinase. IDC-1 antibiotic_resistance ARO:3005012 IDC-1 ARO:3005012 IDC-2 is an IDC beta-lactamase and an integron cephalosprinase. PMID:32183280 IDC-1 IDC-2 is an IDC beta-lactamase and an integron cephalosprinase. IDC-2 antibiotic_resistance ARO:3005013 IDC-2 ARO:3005013 IDC-2 is an IDC beta-lactamase and an integron cephalosprinase. PMID:32183280 IDC-2 Vibro metallo-B-lactamase, also known as VMB is a carbapenemase beta-lactamase gene family. antibiotic_resistance ARO:3005014 VMB beta-lactamase ARO:3005014 Vibro metallo-B-lactamase, also known as VMB is a carbapenemase beta-lactamase gene family. PMID:32293144 Vibrio metallo-B-lactamase 1, also known as VMB-1, is carbapenemase beta-lactamase that is found in plasmid pVB1796 from Vibrio alginolyticus. VMB-1 antibiotic_resistance ARO:3005015 VMB-1 ARO:3005015 Vibrio metallo-B-lactamase 1, also known as VMB-1, is carbapenemase beta-lactamase that is found in plasmid pVB1796 from Vibrio alginolyticus. PMID:32293144 VMB-1 CMY-150 is a CMY-2 variant differing by 15 amino-acid substitutions. It confers higher resistance levels to ceftazidime and aztreonam compared to CMY-2. CMY-150 antibiotic_resistance ARO:3005016 CMY-150 ARO:3005016 CMY-150 is a CMY-2 variant differing by 15 amino-acid substitutions. It confers higher resistance levels to ceftazidime and aztreonam compared to CMY-2. PMID:31785341 CMY-150 LMB is an AMR Gene family belonging to subclass B3 metallo-beta-lactamases. antibiotic_resistance ARO:3005017 LMB beta-lactamase ARO:3005017 LMB is an AMR Gene family belonging to subclass B3 metallo-beta-lactamases. PMID:31785341 LMB-1 is a subclass B3 metallo-beta-lactamase that confers resistance to penams, cephalosporins, and carbapenems. LMB-1 antibiotic_resistance ARO:3005018 LMB-1 ARO:3005018 LMB-1 is a subclass B3 metallo-beta-lactamase that confers resistance to penams, cephalosporins, and carbapenems. PMID:31785341 LMB-1 IMP-68 is a subclass B1 metallo-beta-lactamase that confers resistance to carbapenems. IMP-68 antibiotic_resistance ARO:3005019 IMP-68 ARO:3005019 IMP-68 is a subclass B1 metallo-beta-lactamase that confers resistance to carbapenems. PMID:31666316 IMP-68 The cfr(D) group are cfr(D) genes found in Enterococcus faecium that confer resistance to vancomycin, teicoplanin and linezolid. antibiotic_resistance ARO:3005020 cfr(D) Group ARO:3005020 The cfr(D) group are cfr(D) genes found in Enterococcus faecium that confer resistance to vancomycin, teicoplanin and linezolid. PMID:31685464 PMID:32277823 cfr(D) is found in Enterococcus faecium. It confers resistance to vancomycin, teicoplanin, and linezolid. cfr(D) antibiotic_resistance ARO:3005021 cfr(D) ARO:3005021 cfr(D) is found in Enterococcus faecium. It confers resistance to vancomycin, teicoplanin, and linezolid. PMID:31685464 PMID:32277823 cfr(D) cfr(E) is a cfr-like gene described by (Stojkovic et al, 2019). It is found on transposon Tn6218 and found in Clostridioides difficile. antibiotic_resistance ARO:3005022 cfr(E) Group ARO:3005022 cfr(E) is a cfr-like gene described by (Stojkovic et al, 2019). It is found on transposon Tn6218 and found in Clostridioides difficile. PMID:31685464 The gene cfr(E) is a cfr-like gene found in Clostridioides difficile isolate DF11. It confers resistance to antibiotics targeting to the 23s rRNA through hypermethylation of nucleotide A2503. cfr(E) cfrE antibiotic_resistance ARO:3005023 cfrE ARO:3005023 The gene cfr(E) is a cfr-like gene found in Clostridioides difficile isolate DF11. It confers resistance to antibiotics targeting to the 23s rRNA through hypermethylation of nucleotide A2503. PMID:31685464 cfrE FosL1 is related to FosA-like genes. It is a plasmid-encoded fosfomycin resistant gene found in E. coli. FosL1 antibiotic_resistance ARO:3005024 FosL1 ARO:3005024 FosL1 is related to FosA-like genes. It is a plasmid-encoded fosfomycin resistant gene found in E. coli. PMID:31932373 FosL1 Antibiotic adjuvants shown to inhibit the action of ATP synthase, restoring antibiotic activity by depolarizing the bacterial membrane. antibiotic_resistance ARO:3005025 ATP synthase inhibitor ARO:3005025 Venturicidin A is an ATP synthase inhibitor and antibiotic adjuvant produced in actinomycetes. In the presence of aminoglycoside antibiotics such as gentamicin, Venturicidin A showed to restore susceptibility to aminoglycosides in resistant bacteria. ChEBI:184114 PubChem:6438066 VentA antibiotic_resistance ARO:3005026 venturicidin A ARO:3005026 Venturicidin A is an ATP synthase inhibitor and antibiotic adjuvant produced in actinomycetes. In the presence of aminoglycoside antibiotics such as gentamicin, Venturicidin A showed to restore susceptibility to aminoglycosides in resistant bacteria. PMID:32424122 FRI-4 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter asburiae. FRI-4 antibiotic_resistance ARO:3005027 FRI-4 ARO:3005027 FRI-4 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter asburiae. PMID:30060114 FRI-4 FRI-5 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter cloacae. FRI-5 antibiotic_resistance ARO:3005028 FRI-5 ARO:3005028 FRI-5 FRI-6 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter cloacae. FRI-6 antibiotic_resistance ARO:3005029 FRI-6 ARO:3005029 FRI-6 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter cloacae. PMID:31725164 FRI-6 FRI-7 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter asburiae. FRI-7 antibiotic_resistance ARO:3005030 FRI-7 ARO:3005030 FRI-7 FRI-8 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter sp. 18A13. It is from a plasmid. FRI-8 antibiotic_resistance ARO:3005031 FRI-8 ARO:3005031 FRI-8 FRI-9 is a carbapenem-hydrolyzing Class A beta-lactamase gene found in Enterobacter asburiae. FRI-9 antibiotic_resistance ARO:3005032 FRI-9 ARO:3005032 FRI-9 FLC-1 is part of the FRI beta-lactamase family. It is a class A carbapenem-hydrolyzing beta-lactamase from Enterobacter cloacae. FLC-1 antibiotic_resistance ARO:3005033 FLC-1 ARO:3005033 FLC-1 YRC is a ambler class C beta-lactamase from Yersinia ruckeri. It confers resistance penams and cephalosporins. antibiotic_resistance ARO:3005034 YRC beta-lactamase ARO:3005034 YRC is a ambler class C beta-lactamase from Yersinia ruckeri. It confers resistance penams and cephalosporins. PMID:16553832 YRC-1 is a ampC-like beta-lactamase that confers resistance to penams and cephalosporins. It is an ambler class C beta-lactamase. YRC-1 antibiotic_resistance ARO:3005035 YRC-1 ARO:3005035 YRC-1 is a ampC-like beta-lactamase that confers resistance to penams and cephalosporins. It is an ambler class C beta-lactamase. PMID:16553832 YRC-1 BLMT is a bleomycin (Bm) resistance protein, encoded by the ble gene on the transposon Tn5. This protein confers a survival advantage to Escherichia coli host cells. BLMT confers resistance to bleomycin. BLMT antibiotic_resistance ARO:3005036 BLMT ARO:3005036 BLMT is a bleomycin (Bm) resistance protein, encoded by the ble gene on the transposon Tn5. This protein confers a survival advantage to Escherichia coli host cells. BLMT confers resistance to bleomycin. PMID:9923599 BLMT ADC-159 is an ADC beta-lactamase and a ambler class C beta-lactamase. ADC-159 antibiotic_resistance ARO:3005037 ADC-159 ARO:3005037 ADC-159 PDC-65 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-65 antibiotic_resistance ARO:3005038 PDC-65 ARO:3005038 PDC-65 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-65 PDC-55 is an ambler class C beta-lactamase from Pseudomonas aeruginosa. PDC-55 antibiotic_resistance ARO:3005039 PDC-55 ARO:3005039 PDC-55 is an ambler class C beta-lactamase from Pseudomonas aeruginosa. PMID:25022578 PDC-55 YajC interacts with the AcrAB-TolC efflux pump in a way that in uncharacterized but is shown to grant increased fitness in the presence of linezolid, rifampicin, and vancomycin. YajC antibiotic_resistance ARO:3005040 YajC ARO:3005040 YajC interacts with the AcrAB-TolC efflux pump in a way that in uncharacterized but is shown to grant increased fitness in the presence of linezolid, rifampicin, and vancomycin. PMID:31871033 YajC mlaF from the mla system is a gene proposed to play a part in the transport of phospholipids to the outer membrane. Insertions in mlaF are shown to confer resistance to linezolid. mlaF antibiotic_resistance ARO:3005041 mlaF ARO:3005041 mlaF from the mla system is a gene proposed to play a part in the transport of phospholipids to the outer membrane. Insertions in mlaF are shown to confer resistance to linezolid. PMID:31871033 mlaF mlaD from the mla system is a gene proposed to play a part in the transport of phospholipids to the outer membrane. Insertions in mlaD are shown to confer resistance to linezolid. mlaD antibiotic_resistance ARO:3005042 mlaD ARO:3005042 mlaD from the mla system is a gene proposed to play a part in the transport of phospholipids to the outer membrane. Insertions in mlaD are shown to confer resistance to linezolid. PMID:31871033 mlaD cmlA9 is a Major Facilitator Superfamily efflux gene that is found in Salmonella enterica. FloR2 cmlA9 antibiotic_resistance ARO:3005043 cmlA9 ARO:3005043 cmlA9 is a Major Facilitator Superfamily efflux gene that is found in Salmonella enterica. PMID:25315365 cmlA9 OmpA is a porin that confers resistance to beta-lactam antibiotics. OmpA antibiotic_resistance ARO:3005044 OmpA ARO:3005044 OmpA is a porin that confers resistance to beta-lactam antibiotics. PMID:25341126 OmpA SatA is part of the Streptothricin acetyltransferase gene family. It confers resistance to nucleoside antibiotics. SatA antibiotic_resistance ARO:3005045 SatA ARO:3005045 SatA is part of the Streptothricin acetyltransferase gene family. It confers resistance to nucleoside antibiotics. PMID:12721629 SatA This MecI is a methicillin-resistant repressor resembling MecC. It confers resistance to penams. MecI_rep antibiotic_resistance ARO:3005046 MecC-type methicillin resistance repressor MecI ARO:3005046 This MecI is a methicillin-resistant repressor resembling MecC. It confers resistance to penams. PMID:21641281 MecI_rep eptB is a phosphoethanolamine transferase. It confers resistance to peptide antibiotics. eptB antibiotic_resistance ARO:3005047 eptB ARO:3005047 eptB is a phosphoethanolamine transferase. It confers resistance to peptide antibiotics. PMID:21629720 eptB CrcB is part of the Camphor Resistance Protein Family. It confers resistance to aminoglycoside antibiotics. CrcB antibiotic_resistance ARO:3005049 CrcB ARO:3005049 CrcB is part of the Camphor Resistance Protein Family. It confers resistance to aminoglycoside antibiotics. PMID:23405357 PMID:35631066 CrcB LpsB is involved in lipopolysaccharide synthesis. It provides intrinsic resistance to colistin and other peptide antibiotics such as polymyxins. antibiotic_resistance ARO:3005050 Intrinsic peptide antibiotic resistant Lps ARO:3005050 LpsB is involved in lipopolysaccharide synthesis. It provides intrinsic resistance to colistin and other peptide antibiotics such as polymyxins. PMID:23230287 LpsB is involved in lipopolysaccharide synthesis. It confers intrinsic resistance to colistin and other peptide antibiotics. LpsB antibiotic_resistance ARO:3005051 LpsB ARO:3005051 LpsB is involved in lipopolysaccharide synthesis. It confers intrinsic resistance to colistin and other peptide antibiotics. PMID:23230287 LpsB LpsA plays a role in Lipooligosaccharide biosynthesis. LpsA confers resistance to polymyxin antibiotics. LpsA antibiotic_resistance ARO:3005052 LpsA ARO:3005052 LpsA plays a role in Lipooligosaccharide biosynthesis. LpsA confers resistance to polymyxin antibiotics. PMID:16847057 PMID:23980106 PMID:32284036 LpsA ArnT is involved in Cell Wall Biosynthesis, specifically 4-amino-4-deoxy-L-arabinose (Ara4N). It confers resistance to peptide antibiotics. ArnT antibiotic_resistance ARO:3005053 ArnT ARO:3005053 ArnT is involved in Cell Wall Biosynthesis, specifically 4-amino-4-deoxy-L-arabinose (Ara4N). It confers resistance to peptide antibiotics. PMID:25341126 ArnT Tet(X6) is a tetracycline inactivating enzyme. It is a tet(X) variant. tet(X6) tetX6 antibiotic_resistance ARO:3005056 tet(X6) ARO:3005056 Tet(X6) is a tetracycline inactivating enzyme. It is a tet(X) variant. PMID:32068864 tet(X6) Tet(X5) is a tetracycline inactivating enzyme. It is a variant of tet(X). tet(X5) tetX5 antibiotic_resistance ARO:3005057 tet(X5) ARO:3005057 Tet(X5) is a tetracycline inactivating enzyme. It is a variant of tet(X). PMID:31611352 tet(X5) ABC transporter complex which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. antibiotic_resistance ARO:3005058 mlaFEDB ARO:3005058 ABC transporter complex which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. PMID:19383799 PMID:27529189 PMID:31871033 LptD is involved in LPS transport in a ABC Transporter efflux system. It confers resistance to rifamycin, aminocoumarin, and peptide antibiotics. LptD antibiotic_resistance ARO:3005059 LptD ARO:3005059 LptD is involved in LPS transport in a ABC Transporter efflux system. It confers resistance to rifamycin, aminocoumarin, and peptide antibiotics. PMID:22914622 PMID:31281307 LptD A class D OXA-like beta-lactamase described in the emerging pathogen Cupriavidus gilardii. OXA-837 antibiotic_resistance ARO:3005060 OXA-837 ARO:3005060 A class D OXA-like beta-lactamase described in the emerging pathogen Cupriavidus gilardii. PMID:31578249 OXA-837 A novel aminoglycoside resistance gene identified from Cupriavidus gilardii; AAC(3)-IVb / aacC10 is an aminoglycoside-3-N-acetyltransferase gene which confers resistance to gentamicin and tobramycin. AAC(3)-IVb aacC10 antibiotic_resistance ARO:3005061 AAC(3)-IVb ARO:3005061 A novel aminoglycoside resistance gene identified from Cupriavidus gilardii; AAC(3)-IVb / aacC10 is an aminoglycoside-3-N-acetyltransferase gene which confers resistance to gentamicin and tobramycin. PMID:31578249 AAC(3)-IVb A novel aminoglycoside 3''-adenyltransferase gene and aminoglycoside resistance gene identified from Cupriavidus gilardii. ANT(3'')-Ib / aadA32 confers resistance to spectinomycin and streptomycin. ANT(3'')-Ib aadA32 antibiotic_resistance ARO:3005062 ANT(3'')-Ib ARO:3005062 A novel aminoglycoside 3''-adenyltransferase gene and aminoglycoside resistance gene identified from Cupriavidus gilardii. ANT(3'')-Ib / aadA32 confers resistance to spectinomycin and streptomycin. PMID:31578249 ANT(3'')-Ib cprR is one part of a two-component regulatory system. It with its counterpart cprS induce the Arn operon to confer resistance to peptide antibiotics. cprR antibiotic_resistance ARO:3005063 cprR ARO:3005063 cprR is one part of a two-component regulatory system. It with its counterpart cprS induce the Arn operon to confer resistance to peptide antibiotics. PMID:23006746 cprR cprS is part of a two-component regulatory system that, with its counterpart cprR, induces the Arn operon in the presence of cationic peptides to confer resistance. cprS antibiotic_resistance ARO:3005064 cprS ARO:3005064 cprS is part of a two-component regulatory system that, with its counterpart cprR, induces the Arn operon in the presence of cationic peptides to confer resistance. PMID:23006746 cprS cprRS is a two-component regulatory system. In the presence of cationic peptides, it induces the Arn operon to confer resistance. antibiotic_resistance ARO:3005065 cprRS ARO:3005065 cprRS is a two-component regulatory system. In the presence of cationic peptides, it induces the Arn operon to confer resistance. PMID:10984043 PMID:15608211 PMID:18978025 PMID:23006746 parRS is a two-component sensor that mediates MexXY/OprM and porin OprD to confer resistance to polycationic antibiotics. It has multiple mechanisms of resistance such as LPS modification, efflux mediation and reduced porin pathway. antibiotic_resistance ARO:3005066 parRS ARO:3005066 parRS is a two-component sensor that mediates MexXY/OprM and porin OprD to confer resistance to polycationic antibiotics. It has multiple mechanisms of resistance such as LPS modification, efflux mediation and reduced porin pathway. PMID:10984043 PMID:15608211 PMID:18978025 PMID:21149619 ParS is the sensor component of the two-component ParRS system. Alongside its counterpart ParR, it confers resistance to polycationic antibiotics though regulation of efflux pumps and porins. ParS antibiotic_resistance ARO:3005067 ParS ARO:3005067 ParS is the sensor component of the two-component ParRS system. Alongside its counterpart ParR, it confers resistance to polycationic antibiotics though regulation of efflux pumps and porins. PMID:10984043 PMID:15608211 PMID:18978025 PMID:21149619 ParS ParR is a component of the two-component sensor ParRS. Alongside its counterpart ParS, it confers resistance to polycationic antibiotics through the regulation of efflux components and porins. ParR antibiotic_resistance ARO:3005068 ParR ARO:3005068 ParR is a component of the two-component sensor ParRS. Alongside its counterpart ParS, it confers resistance to polycationic antibiotics through the regulation of efflux components and porins. PMID:10984043 PMID:15608211 PMID:18978025 PMID:21149619 ParR rsmA is a gene that regulates virulence of Pseudomonas aeruginosa. However, its negative effect on MexEF-OprN overexpression has been noted to confer resistance to various antibiotics. It's Escherichia coli homolog is csrA. csrA rsmA antibiotic_resistance ARO:3005069 rsmA ARO:3005069 rsmA is a gene that regulates virulence of Pseudomonas aeruginosa. However, its negative effect on MexEF-OprN overexpression has been noted to confer resistance to various antibiotics. It's Escherichia coli homolog is csrA. PMID:11673439 PMID:16622241 rsmA A glycopeptide antibiotic which binds to essential peptidoglycan hydrolases, thereby preventing autolysis and inhibited cell wall remodelling during growth. ChEBI:66093 ChEMBL:CHEMBL506605 PubChem:16134403 antibiotic_resistance ARO:3005070 complestatin ARO:3005070 A glycopeptide antibiotic which binds to essential peptidoglycan hydrolases, thereby preventing autolysis and inhibited cell wall remodelling during growth. PMID:32051588 A glycopeptide antibiotic which binds to essential peptidoglycan hydrolases, thereby preventing autolysis and cell wall remodelling. ChEBI:221137 PubChem:163285731 antibiotic_resistance ARO:3005071 corbomycin ARO:3005071 A glycopeptide antibiotic which binds to essential peptidoglycan hydrolases, thereby preventing autolysis and cell wall remodelling. PMID:32051588 ROB-13 is a beta-lactamase from the blaROB AMR gene family. It was found in Bibersteinia trehalosi. ROB-13 antibiotic_resistance ARO:3005072 ROB-13 ARO:3005072 ROB-13 ROB-3 is a beta-lactamase from the blaROB AMR gene family. It was found in Moraxella pluranimalium. ROB-3 antibiotic_resistance ARO:3005073 ROB-3 ARO:3005073 ROB-3 ROB-4 is a beta-lactamase from the blaROB AMR gene family. It was found in Moraxella porci. ROB-4 antibiotic_resistance ARO:3005074 ROB-4 ARO:3005074 ROB-4 ROB-5 is a class A beta-lactamase from the blaROB AMR gene family. It was found in Moraxella sp. RCAD0137. ROB-5 antibiotic_resistance ARO:3005075 ROB-5 ARO:3005075 ROB-5 ROB-6 is a class A beta-lactamase from the blaROB AMR gene family. It was first described by Clemente et al. ROB-6 antibiotic_resistance ARO:3005076 ROB-6 ARO:3005076 ROB-6 is a class A beta-lactamase from the blaROB AMR gene family. It was first described by Clemente et al. PMID:26229982 ROB-6 ROB-7 is a class A beta-lactamase from the blaROB AMR gene family. It was first described by Clemente et al. ROB-7 antibiotic_resistance ARO:3005077 ROB-7 ARO:3005077 ROB-7 is a class A beta-lactamase from the blaROB AMR gene family. It was first described by Clemente et al. PMID:26229982 ROB-7 ROB-8 is a class A beta-lactamase from the blaROB AMR gene family. It was first described by Clemente et al. ROB-8 antibiotic_resistance ARO:3005078 ROB-8 ARO:3005078 ROB-8 is a class A beta-lactamase from the blaROB AMR gene family. It was first described by Clemente et al. PMID:26229982 ROB-8 ROB-2 is an extended spectrum class A beta-lactamase from the blaROB AMR gene family It is described by Kadlec et al. ROB-2 antibiotic_resistance ARO:3005079 ROB-2 ARO:3005079 ROB-2 is an extended spectrum class A beta-lactamase from the blaROB AMR gene family It is described by Kadlec et al. PMID:30561662 ROB-2 ROB-10 is a class A beta-lactamase from the blaROB AMR gene family. It was found in Glaesserella parasuis. ROB-10 antibiotic_resistance ARO:3005080 ROB-10 ARO:3005080 ROB-10 Thermus thermophilus ribosomal protein uL3 containing various mutations conferring resistance to tiamulin. Mutations in the ribosomal protein of uL3 acts by interfering with local rRNA conformation thus conferring resistance. Tthe_uL3_PLM antibiotic_resistance ARO:3005081 Thermus thermophilus uL3 mutations conferring resistance to pleuromutilin antibiotics ARO:3005081 Thermus thermophilus ribosomal protein uL3 containing various mutations conferring resistance to tiamulin. Mutations in the ribosomal protein of uL3 acts by interfering with local rRNA conformation thus conferring resistance. PMID:32526926 Tthe_uL3_PLM Ribosomal protein mutations that interfere with the rRNA conformation at the active site thus conferring antibiotic resistance. antibiotic_resistance ARO:3005082 Ribosomal protein mutation conferring resistance to pleuromutilin antibiotics ARO:3005082 Ribosomal protein mutations that interfere with the rRNA conformation at the active site thus conferring antibiotic resistance. PMID:32526926 Mutations in the 23s rRNA of Thermus thermophilus confers resistance to pleuromutilin antibiotics such as tiamulin. Tthe_23S_PLM antibiotic_resistance ARO:3005083 Thermus thermophilus 23s rRNA conferring resistance to pleuromutilin antibiotics ARO:3005083 Mutations in the 23s rRNA of Thermus thermophilus confers resistance to pleuromutilin antibiotics such as tiamulin. PMID:32526926 Tthe_23S_PLM dfrA31 is an antibiotic resistance dihydrofolate reductase from an integron found from Vibrio cholerae. dfrA31 antibiotic_resistance ARO:3005084 dfrA31 ARO:3005084 dfrA31 is an antibiotic resistance dihydrofolate reductase from an integron found from Vibrio cholerae. PMID:22782487 PMID:23162539 dfrA31 AAC(3)-IIg is part of the AAC(3) family. It was initially found in clinical isolates of Enterobacter cloacae. AAC(3)-IIg antibiotic_resistance ARO:3005085 AAC(3)-IIg ARO:3005085 AAC(3)-IIg is part of the AAC(3) family. It was initially found in clinical isolates of Enterobacter cloacae. PMID:32571822 AAC(3)-IIg Fusidic acid resistance determinants through the mediation of target protection. These protein drive the dissociation of EF-G from the ribosome thus counteracting the action of Fusidic acid. antibiotic_resistance ARO:3005086 Target protecting FusB-type protein conferring resistance to Fusidic acid ARO:3005086 Fusidic acid resistance determinants through the mediation of target protection. These protein drive the dissociation of EF-G from the ribosome thus counteracting the action of Fusidic acid. PMID:21968364 PMID:22308410 PMID:26781961 msrF is an ABC-F binding cassette ribosomal protection protein. It confers resistance to macrolide antibiotics. msrF antibiotic_resistance ARO:3005087 msrF ARO:3005087 msrF is an ABC-F binding cassette ribosomal protection protein. It confers resistance to macrolide antibiotics. PMID:32122903 msrF msrH is a ABC-F binding cassette ribosomal protection protein. It confers resistance to macrolide antibiotics. msrH antibiotic_resistance ARO:3005088 msrH ARO:3005088 msrH is a ABC-F binding cassette ribosomal protection protein. It confers resistance to macrolide antibiotics. PMID:32122903 msrH mef(D) is a major facilitator superfamily efflux pump protein. It works together with the msr proteins to confer resistance to macrolide antibiotics. mef(D) antibiotic_resistance ARO:3005089 mef(D) ARO:3005089 mef(D) is a major facilitator superfamily efflux pump protein. It works together with the msr proteins to confer resistance to macrolide antibiotics. PMID:32122903 mef(D) RanB is the determinant of antibiotic resistance within the RanARanB ABC-type efflux system. It confers resistance to aminoglycoside antibiotics. RanB antibiotic_resistance ARO:3005090 RanB ARO:3005090 RanB is the determinant of antibiotic resistance within the RanARanB ABC-type efflux system. It confers resistance to aminoglycoside antibiotics. PMID:32273020 RanB RanA is a part of the RanARanB ABC-type efflux system. Alongside RanB, it confers resistance to aminoglycoside antibiotics. RanA antibiotic_resistance ARO:3005091 RanA ARO:3005091 RanA is a part of the RanARanB ABC-type efflux system. Alongside RanB, it confers resistance to aminoglycoside antibiotics. PMID:32273020 RanA RanARanB is the combination of both RanA and RanB to form an ABC-type efflux system. RanB confers resistance to aminoglycoside antibiotics. antibiotic_resistance ARO:3005092 RanARanB ARO:3005092 RanARanB is the combination of both RanA and RanB to form an ABC-type efflux system. RanB confers resistance to aminoglycoside antibiotics. PMID:32273020 OXA-899 is a class D beta-lactamase and part of the OXA family. It confers resistance to B-lactams and was originally found in Ralstonia pikettii. OXA-899 antibiotic_resistance ARO:3005093 OXA-899 ARO:3005093 OXA-899 is a class D beta-lactamase and part of the OXA family. It confers resistance to B-lactams and was originally found in Ralstonia pikettii. PMID:32169680 OXA-899 OXA-898 is a class D beta-lactamase from the OXA family. It confers resistance to B-lactams and was originally found in Ralstonia pikettii. OXA-898 antibiotic_resistance ARO:3005094 OXA-898 ARO:3005094 OXA-898 is a class D beta-lactamase from the OXA family. It confers resistance to B-lactams and was originally found in Ralstonia pikettii. PMID:32169680 OXA-898 GPC is a class A beta-lactamase family. It is found initially in Pseudomonas aeruginosa. It confers resistance to B-lactams. antibiotic_resistance ARO:3005095 GPC beta-lactamase ARO:3005095 GPC is a class A beta-lactamase family. It is found initially in Pseudomonas aeruginosa. It confers resistance to B-lactams. PMID:31960033 GPC-1 is a class A beta-lactamase. It is part of the GPC beta-lactamase gene family. Originally found in Pseudomonas aeruginosa. Confers resistance to B-lactams. GPC-1 antibiotic_resistance ARO:3005096 GPC-1 ARO:3005096 GPC-1 is a class A beta-lactamase. It is part of the GPC beta-lactamase gene family. Originally found in Pseudomonas aeruginosa. Confers resistance to B-lactams. PMID:31960033 GPC-1 A blaZ-like beta-lactamase found in S. Aureus. mecC-type_BlaZ antibiotic_resistance ARO:3005097 mecC-type BlaZ ARO:3005097 A blaZ-like beta-lactamase found in S. Aureus. PMID:21636525 mecC-type_BlaZ A subunit of the qac multidrug efflux pump in Vibrio cholerae. qacL antibiotic_resistance ARO:3005098 qacL ARO:3005098 A subunit of the qac multidrug efflux pump in Vibrio cholerae. PMID:16801431 qacL Variant of ErmA (ARO:3000347) found in Streptococcus pyogenes. Confers the MLSb phenotype. Spyo_ErmA_MLSb ermTR antibiotic_resistance ARO:3005099 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) ARO:3005099 Variant of ErmA (ARO:3000347) found in Streptococcus pyogenes. Confers the MLSb phenotype. PMID:9527769 Spyo_ErmA_MLSb Subtype of FosB (ARO:3000172). Present in multiple species. FosB2 antibiotic_resistance ARO:3005100 FosB2 ARO:3005100 Subtype of FosB (ARO:3000172). Present in multiple species. PMID:12721629 FosB2 Mutations associated with katG conferring resistance to prothionamide, an analogue of isoniazid. Like isoniazid, prothionamide targets lnhA. antibiotic_resistance ARO:3005101 prothionamide resistant katG ARO:3005101 Mutations associated with katG conferring resistance to prothionamide, an analogue of isoniazid. Like isoniazid, prothionamide targets lnhA. PMID:30583053 Mutations in Mycobacterium tuberculosis katG conferring resistance to prothionamide, an analogue of isoniazid. Mtub_katG_PTO Rv1908c antibiotic_resistance ARO:3005102 Mycobacterium tuberculosis katG mutations conferring resistance to prothionamide ARO:3005102 Mutations in Mycobacterium tuberculosis katG conferring resistance to prothionamide, an analogue of isoniazid. PMID:30583053 Mtub_katG_PTO Mutations in ethA conferring resistance to isoniazid. antibiotic_resistance ARO:3005103 isoniazid resistant ethA ARO:3005103 Mutations in ethA conferring resistance to isoniazid. PMID:30583053 Mutations in ethA conferring resistance to prothionamide, an analogue of isoniazid. antibiotic_resistance ARO:3005104 prothionamide resistant ethA ARO:3005104 Mutations in ethA conferring resistance to prothionamide, an analogue of isoniazid. PMID:30583053 Mutations in Mycobacterium tuberculosis ethA conferring resistance to isoniazid. Mtub_ethA_INH Rv3854c antibiotic_resistance ARO:3005105 Mycobacterium tuberculosis ethA mutations conferring resistance to isoniazid ARO:3005105 Mutations in Mycobacterium tuberculosis ethA conferring resistance to isoniazid. PMID:19486070 PMID:30583053 Mtub_ethA_INH Mutations in Mycobacterium tuberculosis ethA conferring resistance to prothionamide, an analogue to isoniazid. Mtub_ethA_PTO Rv3854c antibiotic_resistance ARO:3005106 Mycobacterium tuberculosis ethA mutations conferring resistance to prothionamide ARO:3005106 Mutations in Mycobacterium tuberculosis ethA conferring resistance to prothionamide, an analogue to isoniazid. PMID:30337678 PMID:30583053 Mtub_ethA_PTO Mutations in mshA conferring resistance to prothionamide, an analogue of isoniazid. antibiotic_resistance ARO:3005107 prothionamide resistant mshA ARO:3005107 Mutations in Mycobacterium tuberculosis mshA conferring resistance to prothionamide, an analogue to isoniazid. Mtub_mshA_PTO Rv0486 antibiotic_resistance ARO:3005108 Mycobacterium tuberculosis mshA mutations conferring resistance to prothionamide ARO:3005108 Mutations in Mycobacterium tuberculosis mshA conferring resistance to prothionamide, an analogue to isoniazid. PMID:30583053 Mtub_mshA_PTO A class A beta-lactamase in Mycolicibacterium smegmatis. antibiotic_resistance ARO:3005110 blaS ARO:3005110 A class A beta-lactamase in Mycolicibacterium smegmatis. PMID:15699201 PMID:9103972 Predominant beta-lactamase in Mycolicibacterium smegmatis. blaS1 antibiotic_resistance ARO:3005111 blaS1 ARO:3005111 Predominant beta-lactamase in Mycolicibacterium smegmatis. PMID:15699201 PMID:9103972 blaS1 A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Aeromonas. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics. AAC(6')-Ib-cr3 antibiotic_resistance ARO:3005112 AAC(6')-Ib-cr3 ARO:3005112 A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Aeromonas. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics. PMID:22127350 AAC(6')-Ib-cr3 A subfamily of aminoglycoside 6'-N-acetyltransferases, AAC(6'), which doubly confer resistance to aminoglycoside and fluoroquinolone antibiotics through fluoroquinolone-acetylating activity. antibiotic_resistance ARO:3005113 AAC(6')-Ib-cr ARO:3005113 A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Enterobacter. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics. AAC(6')-Ib-cr4 antibiotic_resistance ARO:3005114 AAC(6')-Ib-cr4 ARO:3005114 A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Enterobacter. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics. PMID:23361643 AAC(6')-Ib-cr4 A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Pseudomonas. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics. AAC(6')-Ib-cr5 antibiotic_resistance ARO:3005115 AAC(6')-Ib-cr5 ARO:3005115 A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Pseudomonas. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics. PMID:34909689 AAC(6')-Ib-cr5 A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Escherichia coli. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics. AAC(6')-Ib-cr6 antibiotic_resistance ARO:3005116 AAC(6')-Ib-cr6 ARO:3005116 A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Escherichia coli. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics. PMID:33295867 AAC(6')-Ib-cr6 A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Klebsiella. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics. AAC(6')-Ib-cr7 antibiotic_resistance ARO:3005117 AAC(6')-Ib-cr7 ARO:3005117 A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Klebsiella. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics. PMID:25691640 AAC(6')-Ib-cr7 A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant, identified from Salmonella. These variants confers resistance to both aminoglycoside and fluoroquinolone antibiotics. AAC(6')-Ib-cr8 antibiotic_resistance ARO:3005118 AAC(6')-Ib-cr8 ARO:3005118 AAC(6')-Ib-cr8 A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant, identified from Serratia. These variants confers resistance to both aminoglycoside and fluoroquinolone antibiotics. AAC(6')-Ib-cr9 antibiotic_resistance ARO:3005119 AAC(6')-Ib-cr9 ARO:3005119 AAC(6')-Ib-cr9 A novel broad-spectrum anti-MRSA benzoquinolizine antibiotic effective against gram-positive and gram-negative pathogens. PubChem:9850038 antibiotic_resistance ARO:3005120 levonadifloxacin ARO:3005120 A novel broad-spectrum anti-MRSA benzoquinolizine antibiotic effective against gram-positive and gram-negative pathogens. PMID:31920285 The lsa(D) gene represents an ABC-F subfamily protein expressed in Lactococcus garvieae. It confers resistance to Streptogramins A, Pleuromutilins and Lincosamides. lsa(D) lsaD antibiotic_resistance ARO:3005121 lsaD ARO:3005121 The lsa(D) gene represents an ABC-F subfamily protein expressed in Lactococcus garvieae. It confers resistance to Streptogramins A, Pleuromutilins and Lincosamides. PMID:32706619 lsaD PDC-68 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-68 antibiotic_resistance ARO:3005122 PDC-68 ARO:3005122 PDC-68 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-68 PDC-70 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-70 antibiotic_resistance ARO:3005123 PDC-70 ARO:3005123 PDC-70 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-70 PDC-63 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-63 antibiotic_resistance ARO:3005124 PDC-63 ARO:3005124 PDC-63 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-63 PDC-57 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-57 antibiotic_resistance ARO:3005125 PDC-57 ARO:3005125 PDC-57 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-57 PDC-66 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-66 antibiotic_resistance ARO:3005126 PDC-66 ARO:3005126 PDC-66 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-66 PDC-14 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-14 antibiotic_resistance ARO:3005127 PDC-14 ARO:3005127 PDC-14 PDC-47 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-47 antibiotic_resistance ARO:3005128 PDC-47 ARO:3005128 PDC-47 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-47 PDC-51 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-51 antibiotic_resistance ARO:3005129 PDC-51 ARO:3005129 PDC-51 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-51 OXA-846 is a class D beta-lactamase found in Pseudomonas aeruginosa. It is part of the OXA-50 family of oxacillin-hydrolyzing beta-lactamase. OXA-846 antibiotic_resistance ARO:3005130 OXA-846 ARO:3005130 OXA-846 An NDM metallo-beta-lactamase variant reported in Klebsiella pneumoniae. NDM-29 antibiotic_resistance ARO:3005131 NDM-29 ARO:3005131 NDM-29 PDC-11 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-11 antibiotic_resistance ARO:3005132 PDC-11 ARO:3005132 PDC-11 PDC-62 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-62 antibiotic_resistance ARO:3005133 PDC-62 ARO:3005133 PDC-62 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-62 PDC-43 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-43 antibiotic_resistance ARO:3005134 PDC-43 ARO:3005134 PDC-43 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-43 PDC-54 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-54 antibiotic_resistance ARO:3005135 PDC-54 ARO:3005135 PDC-54 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-54 OXA-906 is a class D beta-lactamase from the OXA-50 family found in Pseudomonas aeruginosa. OXA-906 antibiotic_resistance ARO:3005136 OXA-906 ARO:3005136 OXA-906 PDC-59 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-59 antibiotic_resistance ARO:3005137 PDC-59 ARO:3005137 PDC-59 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-59 Pseudomonas aeruginosa strain OXA-50 family oxacillin-hydrolyzing class D beta-lactamase. OXA-850 antibiotic_resistance ARO:3005138 OXA-850 ARO:3005138 OXA-850 PDC-67 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa strain 5065. PDC-67 antibiotic_resistance ARO:3005139 PDC-67 ARO:3005139 PDC-67 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa strain 5065. PMID:25022578 PDC-67 PDC-56 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa strain 4883. PDC-56 antibiotic_resistance ARO:3005140 PDC-56 ARO:3005140 PDC-56 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa strain 4883. PMID:25022578 PDC-56 PDC-52 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-52 antibiotic_resistance ARO:3005141 PDC-52 ARO:3005141 PDC-52 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-52 PDC-44 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-44 antibiotic_resistance ARO:3005142 PDC-44 ARO:3005142 PDC-44 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-44 PDC-240 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-240 antibiotic_resistance ARO:3005143 PDC-240 ARO:3005143 PDC-240 PDC-61 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-61 antibiotic_resistance ARO:3005144 PDC-61 ARO:3005144 PDC-61 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-61 PDC-45 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-45 antibiotic_resistance ARO:3005145 PDC-45 ARO:3005145 PDC-45 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-45 PDC-49 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-49 antibiotic_resistance ARO:3005146 PDC-49 ARO:3005146 PDC-49 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-49 PDC-50 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-50 antibiotic_resistance ARO:3005147 PDC-50 ARO:3005147 PDC-50 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-50 PDC-48 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-48 antibiotic_resistance ARO:3005148 PDC-48 ARO:3005148 PDC-48 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-48 PAC beta-lactamase is an inhibitior-resistant cephalosporin-hydrolyzing class C beta-lactamase. antibiotic_resistance ARO:3005149 PAC beta-lactamase ARO:3005149 PAC-1 is an ambler class C beta-lactamase from the PAC beta-lactamase family. It is found in Pseudomonas aeruginosa. PAC-1 antibiotic_resistance ARO:3005150 PAC-1 ARO:3005150 PAC-1 PDC-53 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-53 antibiotic_resistance ARO:3005151 PDC-53 ARO:3005151 PDC-53 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-53 PDC-72 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-72 antibiotic_resistance ARO:3005152 PDC-72 ARO:3005152 PDC-72 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-72 PDC-69 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-69 antibiotic_resistance ARO:3005153 PDC-69 ARO:3005153 PDC-69 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-69 PDC-23 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-23 antibiotic_resistance ARO:3005155 PDC-23 ARO:3005155 PDC-23 PDC-28 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-28 antibiotic_resistance ARO:3005156 PDC-28 ARO:3005156 PDC-28 PDC-41 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PDC-41 antibiotic_resistance ARO:3005157 PDC-41 ARO:3005157 PDC-41 is an ambler class C beta-lactamase found in Pseudomonas aeruginosa. PMID:25022578 PDC-41 OXA-668 is a class D beta-lactamase from the OXA-274 family of OXA beta-lactamases. OXA-668 antibiotic_resistance ARO:3005158 OXA-668 ARO:3005158 OXA-668 OXA-818 is a class D beta-lactamase from the OXA-23 family of OXA beta-lactamases. OXA-818 antibiotic_resistance ARO:3005159 OXA-818 ARO:3005159 OXA-818 OXA-812 is a class D beta-lactamase from the OXA-23 family of OXA beta-lactamases. OXA-812 antibiotic_resistance ARO:3005160 OXA-812 ARO:3005160 OXA-812 FosA7.5 is a variant of the FosA7 gene. This gene is unique from FosA7 in that it is found in Escherichia coli as opposed to Salmonella enterica. It confers resistance to fosfomycin. FosA7.5 antibiotic_resistance ARO:3005162 FosA7.5 ARO:3005162 FosA7.5 is a variant of the FosA7 gene. This gene is unique from FosA7 in that it is found in Escherichia coli as opposed to Salmonella enterica. It confers resistance to fosfomycin. PMID:33077665 FosA7.5 Ionophores are chemical entities which reversibly bind ions. Many ionophores display antibacterial and antifungal properties. An ionophore will bind and transport ions through a cell membrane, thereby potentially disrupting membrane potential and modifying permeability. antibiotic_resistance ARO:3005163 ionophore with antibiotic activity ARO:3005163 Ionophores are chemical entities which reversibly bind ions. Many ionophores display antibacterial and antifungal properties. An ionophore will bind and transport ions through a cell membrane, thereby potentially disrupting membrane potential and modifying permeability. PMID:22849267 dfrA35 is a trimethoprim resistant dihydrofolate reductase gene found in the lncC plasmid pEc158 from E.coli. dfrA35 antibiotic_resistance ARO:3005164 dfrA35 ARO:3005164 dfrA35 is a trimethoprim resistant dihydrofolate reductase gene found in the lncC plasmid pEc158 from E.coli. PMID:30989199 dfrA35 In an antimicrobial context, a drug class is a set of antibiotic molecules, including antibiotic/adjuvant combination medications, with similar chemical structures, molecular targets, and/or modes and mechanisms of action. antibiotic_resistance ARO:3005165 antibiotic drug class ARO:3005165 Tetracycline resistance gene tet(X) ortholog described by Fang et al. 2020. tet(X1) tetX1 antibiotic_resistance ARO:3005166 tet(X1) ARO:3005166 Tetracycline resistance gene tet(X) ortholog described by Fang et al. 2020. PMID:32567703 tet(X1) A class of organic compounds derived from aromatic compounds and exhibiting antibiotic activity. antibiotic_resistance ARO:3005167 quinone with antibiotic activity ARO:3005167 A class of compounds containing an aromatic moiety and an aliphatic chain, produced as a bacterial metabolite and exhibiting antibiotic properties to many gram-positive pathogens. antibiotic_resistance ARO:3005168 ansamycin antibiotic ARO:3005168 Alkaloids are naturally occurring organic compounds containing the element nitrogen. Some alkaloid compounds exhibit specific antibacterial activity. antibiotic_resistance ARO:3005169 alkaloids with antibiotic activity ARO:3005169 A metallophore is any organic substance capable of carrying a metallic element such as zinc or iron, typically through chelation. Some metallophores exhibit specific antibiotic activity. antibiotic_resistance ARO:3005170 metallophores with antibiotic activity ARO:3005170 Polyketides are a large group of secondary metabolites. Some polyketide compounds have been shown to possess antibiotic activity and qualities. antibiotic_resistance ARO:3005171 polyketide with antibiotic activity ARO:3005171 Terpenes are a large class of naturally produced organic compounds, predominantly produced by plants such as conifers. Some terpenes have been shown to possess antibiotic qualities or activity. antibiotic_resistance ARO:3005172 terpene with antibiotic activity ARO:3005172 Derivatives of thiacalixarene exhibit antiseptic and antibacterial activity. PubChem:335377 antibiotic_resistance ARO:3005174 thiacalixarene derivatives ARO:3005174 Derivatives of thiacalixarene exhibit antiseptic and antibacterial activity. PMID:33310546 Perchlozone is a novel thiosemicarbazone used for the treatment of multidrug-resistant tuberculosis. It is similar to thiacetazone with only a different side chain attached to the thiosemicarbazone moiety. Perchlozone is a prodrug that is activated by ethA and inhibits the HadABC complex. PubChem:5374694 4-thioureido-iminomethylpyridinium perchlorate antibiotic_resistance ARO:3005175 perchlozone ARO:3005175 Perchlozone is a novel thiosemicarbazone used for the treatment of multidrug-resistant tuberculosis. It is similar to thiacetazone with only a different side chain attached to the thiosemicarbazone moiety. Perchlozone is a prodrug that is activated by ethA and inhibits the HadABC complex. PMID:25704063 PMID:33022959 CMY-158 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. CMY-158 antibiotic_resistance ARO:3005176 CMY-158 ARO:3005176 CMY-158 CMY-173 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. CMY-173 antibiotic_resistance ARO:3005177 CMY-173 ARO:3005177 CMY-173 Mutations in ethA conferring resistance to perchlozone, a novel thiosemicarbazone. Mtub_ethA_PCL Rv3854c antibiotic_resistance ARO:3005178 Mycobacterium tuberculosis ethA mutations conferring resistance to perchlozone ARO:3005178 Mutations in ethA conferring resistance to perchlozone, a novel thiosemicarbazone. PMID:33022959 Mtub_ethA_PCL CMY-147 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. CMY-147 antibiotic_resistance ARO:3005180 CMY-147 ARO:3005180 CMY-147 CMY-146 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. CMY-146 antibiotic_resistance ARO:3005181 CMY-146 ARO:3005181 CMY-146 CMY-156 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. CMY-156 antibiotic_resistance ARO:3005182 CMY-156 ARO:3005182 CMY-156 CMY-160 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. CMY-160 antibiotic_resistance ARO:3005183 CMY-160 ARO:3005183 CMY-160 CMY-162 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. CMY-162 antibiotic_resistance ARO:3005184 CMY-162 ARO:3005184 CMY-162 CMY-140 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. CMY-140 antibiotic_resistance ARO:3005185 CMY-140 ARO:3005185 CMY-140 CMY-164 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. CMY-164 antibiotic_resistance ARO:3005186 CMY-164 ARO:3005186 CMY-164 CMY-161 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. CMY-161 antibiotic_resistance ARO:3005187 CMY-161 ARO:3005187 CMY-161 CMY-165 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. CMY-165 antibiotic_resistance ARO:3005188 CMY-165 ARO:3005188 CMY-165 CMY-166 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. CMY-166 antibiotic_resistance ARO:3005189 CMY-166 ARO:3005189 CMY-166 CMY-149 is a beta-lactamase found in Proteus mirabilis. It confers resistance to cephamycin. CMY-149 antibiotic_resistance ARO:3005190 CMY-149 ARO:3005190 CMY-149 CMY-139 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. CMY-139 antibiotic_resistance ARO:3005191 CMY-139 ARO:3005191 CMY-139 CMY-148 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. CMY-148 antibiotic_resistance ARO:3005192 CMY-148 ARO:3005192 CMY-148 CMY-163 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. CMY-163 antibiotic_resistance ARO:3005193 CMY-163 ARO:3005193 CMY-163 CMY-154 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. CMY-154 antibiotic_resistance ARO:3005194 CMY-154 ARO:3005194 CMY-154 CMY-142 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. CMY-142 antibiotic_resistance ARO:3005195 CMY-142 ARO:3005195 CMY-142 CMY-141 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. CMY-141 antibiotic_resistance ARO:3005196 CMY-141 ARO:3005196 CMY-141 CMY-145 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. CMY-145 antibiotic_resistance ARO:3005197 CMY-145 ARO:3005197 CMY-145 CMY-96 is a beta-lactamase found in Citrobacter sp. It confers resistance to cephamycin. CMY-157 antibiotic_resistance ARO:3005198 CMY-157 ARO:3005198 CMY-157 CMY-171 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. CMY-171 antibiotic_resistance ARO:3005199 CMY-171 ARO:3005199 CMY-171 CMY-155 is a beta-lactamase found in Klebsiella sp. KF07. It confers resistance to cephamycin. CMY-155 antibiotic_resistance ARO:3005200 CMY-155 ARO:3005200 CMY-155 An experimental polypyridine ligand used as a metallo-beta-lactamase inhibitor. PubChem:10890081 N,N'-bis(2-pyridylmethyl)-ethylenediamine antibiotic_resistance ARO:3005201 bispicen ARO:3005201 An experimental polypyridine ligand used as a metallo-beta-lactamase inhibitor. PMID:33285370 An experimental polypyridine ligand used as a metallo-beta-lactamase inhibitor. PubChem:15845745 N,N,N'-tris(2-pyridylmethyl)-ethylenediamine antibiotic_resistance ARO:3005202 trispicen ARO:3005202 An experimental polypyridine ligand used as a metallo-beta-lactamase inhibitor. PMID:33285370 CMY-143 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. CMY-143 antibiotic_resistance ARO:3005204 CMY-143 ARO:3005204 CMY-143 Genetic variants of ethA from Mycobacterium spp. including tuberculosis, which confer resistance to the antibiotic perchlozone. antibiotic_resistance ARO:3005205 perchlozone resistant ethA ARO:3005205 A beta-lactamase gene found in Klebsiella pneumoniae. SHV-205 antibiotic_resistance ARO:3005207 SHV-205 ARO:3005207 SHV-205 A beta-lactamase gene from Klebsiella pneumoniae. SHV-222 antibiotic_resistance ARO:3005208 SHV-222 ARO:3005208 SHV-222 A beta-lactamase gene from Klebsiella pneumoniae. SHV-198 antibiotic_resistance ARO:3005209 SHV-198 ARO:3005209 SHV-198 Beta-lactamase gene from Klebsiella pneumoniae. SHV-195 antibiotic_resistance ARO:3005210 SHV-195 ARO:3005210 SHV-195 Beta-lactamase gene from Klebsiella pneumoniae. SHV-201 antibiotic_resistance ARO:3005211 SHV-201 ARO:3005211 SHV-201 A beta-lactamase gene from Klebsiella pneumoniae. SHV-212 antibiotic_resistance ARO:3005212 SHV-212 ARO:3005212 SHV-212 A beta-lactamase gene from Klebsiella pneumoniae. SHV-204 antibiotic_resistance ARO:3005213 SHV-204 ARO:3005213 SHV-204 A beta-lactamase gene from Escherichia coli. SHV-197 antibiotic_resistance ARO:3005214 SHV-197 ARO:3005214 SHV-197 A beta-lactamase gene from Klebsiella pneumoniae. SHV-216 antibiotic_resistance ARO:3005215 SHV-216 ARO:3005215 SHV-216 CMY-152 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. CMY-152 antibiotic_resistance ARO:3005216 CMY-152 ARO:3005216 CMY-152 CMY-151 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. CMY-151 antibiotic_resistance ARO:3005217 CMY-151 ARO:3005217 CMY-151 CMY-89 is a beta-lactamase found in Escherichia coli. It confers resistance to cephamycin. CMY-153 antibiotic_resistance ARO:3005218 CMY-153 ARO:3005218 CMY-153 CMY-144 is a beta-lactamase found in Citrobacter freundii. It confers resistance to cephamycin. CMY-144 antibiotic_resistance ARO:3005219 CMY-144 ARO:3005219 CMY-144 CMY-138 is a beta-lactamase found in Proteus mirabilis. It confers resistance to cephamycin. CMY-138 antibiotic_resistance ARO:3005220 CMY-138 ARO:3005220 CMY-138 Novel mcr-3.41 gene identified in an Aeromonas veronii C198 isolate from a patient with Septicemia in Thailand by Hatrongjit et. al. MCR-3.41 antibiotic_resistance ARO:3005221 MCR-3.41 ARO:3005221 Novel mcr-3.41 gene identified in an Aeromonas veronii C198 isolate from a patient with Septicemia in Thailand by Hatrongjit et. al. PMID:33317051 MCR-3.41 OXA-544 is a beta-lactamase in the OXA-2 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-544 antibiotic_resistance ARO:3005222 OXA-544 ARO:3005222 OXA-544 Beta-lactamase gene from Klebsiella pneumoniae. SHV-194 antibiotic_resistance ARO:3005223 SHV-194 ARO:3005223 SHV-194 Beta-lactamase gene from Klebsiella pneumoniae. SHV-220 antibiotic_resistance ARO:3005224 SHV-220 ARO:3005224 SHV-220 Beta-lactamase gene from Klebsiella pneumoniae. SHV-210 antibiotic_resistance ARO:3005225 SHV-210 ARO:3005225 SHV-210 A beta-lactamase gene found in Klebsiella pneumoniae. SHV-208 antibiotic_resistance ARO:3005226 SHV-208 ARO:3005226 SHV-208 A beta-lactamase gene from Klebsiella pneumoniae. SHV-206 antibiotic_resistance ARO:3005227 SHV-206 ARO:3005227 SHV-206 A beta-lactamase gene found in Klebsiella pneumoniae. SHV-226 antibiotic_resistance ARO:3005228 SHV-226 ARO:3005228 SHV-226 A beta-lactamase gene found in Klebsiella pneumoniae. SHV-196 antibiotic_resistance ARO:3005229 SHV-196 ARO:3005229 SHV-196 A beta-lactamase gene found in Klebsiella pneumoniae. SHV-211 antibiotic_resistance ARO:3005230 SHV-211 ARO:3005230 SHV-211 Beta-lactamase gene from Klebsiella pneumoniae. SHV-219 antibiotic_resistance ARO:3005231 SHV-219 ARO:3005231 SHV-219 A beta-lactamase gene found in Escherichia coli. SHV-199 antibiotic_resistance ARO:3005232 SHV-199 ARO:3005232 SHV-199 Beta-lactamase gene from Klebsiella pneumoniae. SHV-227 antibiotic_resistance ARO:3005233 SHV-227 ARO:3005233 SHV-227 A beta-lactamase gene found in Klebsiella pneumonia. SHV-223 antibiotic_resistance ARO:3005234 SHV-223 ARO:3005234 SHV-223 A beta-lactamase gene found in Klebsiella pneumoniae. SHV-214 antibiotic_resistance ARO:3005235 SHV-214 ARO:3005235 SHV-214 A beta-lactamase gene found in Klebsiella penumoniae. SHV-207 antibiotic_resistance ARO:3005236 SHV-207 ARO:3005236 SHV-207 A beta-lactamase gene found in Klebsiella pneumoniae. SHV-1b-b antibiotic_resistance ARO:3005237 SHV-1b-b ARO:3005237 SHV-1b-b A beta-lactamase gene found in Klebsiella pneumoniae. SHV-218 antibiotic_resistance ARO:3005238 SHV-218 ARO:3005238 SHV-218 A beta-lactamase gene found in Klebsiella pneumoniae. SHV-193 antibiotic_resistance ARO:3005239 SHV-193 ARO:3005239 SHV-193 A beta-lactamase gene found in Klebsiella pneumoniae. SHV-224 antibiotic_resistance ARO:3005240 SHV-224 ARO:3005240 SHV-224 A beta-lactamase gene found in Klebsiella pneumoniae. SHV-225 antibiotic_resistance ARO:3005241 SHV-225 ARO:3005241 SHV-225 A beta-lactamase gene found in Klebsiella pneumoniae. SHV-209 antibiotic_resistance ARO:3005242 SHV-209 ARO:3005242 SHV-209 A beta-lactamase gene found in Klebsiella pneumoniae. SHV-215 antibiotic_resistance ARO:3005243 SHV-215 ARO:3005243 SHV-215 ADC ortholog described by Nodari et al. 2020. ADC 181 ADC-181 antibiotic_resistance ARO:3005244 ADC-181 ARO:3005244 ADC ortholog described by Nodari et al. 2020. PMID:33329450 ADC-181 ADC ortholog described by Nodari et al. 2020. ADC 182 ADC-182 antibiotic_resistance ARO:3005245 ADC-182 ARO:3005245 ADC ortholog described by Nodari et al. 2020. PMID:33329450 ADC-182 ADC ortholog described by Nodari et al. 2020. ADC 183 ADC-183 antibiotic_resistance ARO:3005246 ADC-183 ARO:3005246 ADC ortholog described by Nodari et al. 2020. PMID:33329450 ADC-183 A beta-lactamase gene found in Klebsiella pneumoniae. SHV-228 antibiotic_resistance ARO:3005247 SHV-228 ARO:3005247 SHV-228 A beta-lactamase gene found in Klebsiella pneumoniae. SHV-200 antibiotic_resistance ARO:3005248 SHV-200 ARO:3005248 SHV-200 A beta-lactamase gene found in Klebsiella pneumoniae. SHV-203 antibiotic_resistance ARO:3005249 SHV-203 ARO:3005249 SHV-203 A beta-lactamase gene found in Klebsiella pneumoniae. SHV-217 antibiotic_resistance ARO:3005250 SHV-217 ARO:3005250 SHV-217 A beta-lactamase gene found in Klebsiella pneumoniae. SHV-213 antibiotic_resistance ARO:3005251 SHV-213 ARO:3005251 SHV-213 A beta-lactamase gene found in Klebsiella pneumonia. SHV-221 antibiotic_resistance ARO:3005252 SHV-221 ARO:3005252 SHV-221 A beta-lactamase gene found in Klebsiella pneumoniae. SHV-202 antibiotic_resistance ARO:3005253 SHV-202 ARO:3005253 SHV-202 TEM-224 is a beta-lactamase. TEM-224 antibiotic_resistance ARO:3005255 TEM-224 ARO:3005255 TEM-224 TEM-225 is a beta-lactamase. TEM-225 antibiotic_resistance ARO:3005256 TEM-225 ARO:3005256 TEM-225 TEM-226 is a beta lactamase. TEM-226 antibiotic_resistance ARO:3005257 TEM-226 ARO:3005257 TEM-226 TEM-227 is a beta-lactamase. TEM-227 antibiotic_resistance ARO:3005258 TEM-227 ARO:3005258 TEM-227 TEM-228 is a beta lactamase. TEM-228 antibiotic_resistance ARO:3005259 TEM-228 ARO:3005259 TEM-228 TEM-229 is a beta-lactamase. TEM-229 antibiotic_resistance ARO:3005260 TEM-229 ARO:3005260 TEM-229 TEM-230 is a beta-lactamase. TEM-230 antibiotic_resistance ARO:3005261 TEM-230 ARO:3005261 TEM-230 TEM-231 is a beta-lactamase. TEM-231 antibiotic_resistance ARO:3005262 TEM-231 ARO:3005262 TEM-231 TEM-232 is a beta-lactamase. TEM-232 antibiotic_resistance ARO:3005263 TEM-232 ARO:3005263 TEM-232 TEM-233 is a beta-lactamase. TEM-233 antibiotic_resistance ARO:3005264 TEM-233 ARO:3005264 TEM-233 TEM-234 is a beta-lactamase. TEM-234 antibiotic_resistance ARO:3005265 TEM-234 ARO:3005265 TEM-234 TEM-235 is a beta-lactamase. TEM-235 antibiotic_resistance ARO:3005266 TEM-235 ARO:3005266 TEM-235 is a beta-lactamase. PMID:19713526 TEM-235 TEM-236 is a beta-lactamase. TEM-236 antibiotic_resistance ARO:3005267 TEM-236 ARO:3005267 TEM-236 TEM-237 is a beta-lactamase. TEM-237 antibiotic_resistance ARO:3005268 TEM-237 ARO:3005268 TEM-237 TEM-238 is a beta-lactamase. TEM-238 antibiotic_resistance ARO:3005269 TEM-238 ARO:3005269 TEM-238 TEM-240 is a beta-lactamase. TEM-240 antibiotic_resistance ARO:3005270 TEM-240 ARO:3005270 TEM-240 TEM-241 is a beta-lactamase. TEM-241 antibiotic_resistance ARO:3005271 TEM-241 ARO:3005271 TEM-241 TEM-242 is a beta-lactamase. TEM-242 antibiotic_resistance ARO:3005272 TEM-242 ARO:3005272 TEM-242 TEM-243 is a beta-lactamase. TEM-243 antibiotic_resistance ARO:3005273 TEM-243 ARO:3005273 TEM-243 PDC-225 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-225 antibiotic_resistance ARO:3005274 PDC-225 ARO:3005274 PDC-225 PDC-438 is class C beta-lactamase found in Pseudomonas aeruginosa. PDC-438 antibiotic_resistance ARO:3005275 PDC-438 ARO:3005275 PDC-438 PDC-284 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-284 antibiotic_resistance ARO:3005276 PDC-284 ARO:3005276 PDC-284 PDC-105 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-105 antibiotic_resistance ARO:3005277 PDC-105 ARO:3005277 PDC-105 PDC-118 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-118 antibiotic_resistance ARO:3005278 PDC-118 ARO:3005278 PDC-118 PDC-324 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-324 antibiotic_resistance ARO:3005279 PDC-324 ARO:3005279 PDC-324 PDC-323 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-323 antibiotic_resistance ARO:3005280 PDC-323 ARO:3005280 PDC-323 PDC-258 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-258 antibiotic_resistance ARO:3005281 PDC-258 ARO:3005281 PDC-258 PDC-413 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-413 antibiotic_resistance ARO:3005282 PDC-413 ARO:3005282 PDC-413 PDC-384 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-384 antibiotic_resistance ARO:3005283 PDC-384 ARO:3005283 PDC-384 PDC-264 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-264 antibiotic_resistance ARO:3005284 PDC-264 ARO:3005284 PDC-264 PDC-201 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-201 antibiotic_resistance ARO:3005285 PDC-201 ARO:3005285 PDC-201 PDC-346 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-346 antibiotic_resistance ARO:3005286 PDC-346 ARO:3005286 PDC-346 PDC-285 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-285 antibiotic_resistance ARO:3005287 PDC-285 ARO:3005287 PDC-285 PDC-337 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-337 antibiotic_resistance ARO:3005288 PDC-337 ARO:3005288 PDC-337 PDC-212 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-212 antibiotic_resistance ARO:3005289 PDC-212 ARO:3005289 PDC-212 PDC-352 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-352 antibiotic_resistance ARO:3005290 PDC-352 ARO:3005290 PDC-352 PDC-464 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-464 antibiotic_resistance ARO:3005291 PDC-464 ARO:3005291 PDC-464 PDC-19b is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-19b antibiotic_resistance ARO:3005292 PDC-19b ARO:3005292 PDC-19b PDC-380 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-380 antibiotic_resistance ARO:3005293 PDC-380 ARO:3005293 PDC-380 PDC-461 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-461 antibiotic_resistance ARO:3005294 PDC-461 ARO:3005294 PDC-461 PDC-19a is a class C beta-lactamase found in Pseudomonas (multispecies). PDC-19a antibiotic_resistance ARO:3005295 PDC-19a ARO:3005295 PDC-19a PDC-272 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-272 antibiotic_resistance ARO:3005296 PDC-272 ARO:3005296 PDC-272 PDC-255 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-255 antibiotic_resistance ARO:3005297 PDC-255 ARO:3005297 PDC-255 PDC-293 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-293 antibiotic_resistance ARO:3005298 PDC-293 ARO:3005298 PDC-293 PDC-183 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-183 antibiotic_resistance ARO:3005299 PDC-183 ARO:3005299 PDC-183 PDC-207 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-207 antibiotic_resistance ARO:3005300 PDC-207 ARO:3005300 PDC-207 PDC-306 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-306 antibiotic_resistance ARO:3005301 PDC-306 ARO:3005301 PDC-306 PDC-376 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-376 antibiotic_resistance ARO:3005302 PDC-376 ARO:3005302 PDC-376 PDC-117 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-117 antibiotic_resistance ARO:3005303 PDC-117 ARO:3005303 PDC-117 PDC-231 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-231 antibiotic_resistance ARO:3005304 PDC-231 ARO:3005304 PDC-231 PDC-104 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-104 antibiotic_resistance ARO:3005305 PDC-104 ARO:3005305 PDC-104 PDC-173 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-173 antibiotic_resistance ARO:3005306 PDC-173 ARO:3005306 PDC-173 PDC-292 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-292 antibiotic_resistance ARO:3005307 PDC-292 ARO:3005307 PDC-292 PDC-393 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-393 antibiotic_resistance ARO:3005308 PDC-393 ARO:3005308 PDC-393 PDC-119 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-119 antibiotic_resistance ARO:3005309 PDC-119 ARO:3005309 PDC-119 PDC-313 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-313 antibiotic_resistance ARO:3005310 PDC-313 ARO:3005310 PDC-313 PDC-257 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-257 antibiotic_resistance ARO:3005311 PDC-257 ARO:3005311 PDC-257 PDC-429 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-429 antibiotic_resistance ARO:3005312 PDC-429 ARO:3005312 PDC-429 PDC-449 is a class C beta-lactamase found in Pseudomonas aeruginosa. PDC-449 antibiotic_resistance ARO:3005313 PDC-449 ARO:3005313 PDC-449 OXA-540 is a beta-lactamase in the OXA-2 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-540 antibiotic_resistance ARO:3005314 OXA-540 ARO:3005314 OXA-540 OXA-779 is a beta-lactamase in the OXA-46 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-779 antibiotic_resistance ARO:3005315 OXA-779 ARO:3005315 OXA-779 OXA-838 is a beta-lactamase in the OXA-2 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-838 antibiotic_resistance ARO:3005316 OXA-838 ARO:3005316 OXA-838 OXA-539 is a beta-lactamase in the OXA-2 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-539 antibiotic_resistance ARO:3005317 OXA-539 ARO:3005317 OXA-539 is a beta-lactamase in the OXA-2 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. PMID:28674059 OXA-539 OXA-543 is a beta-lactamase in the OXA-2 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-543 antibiotic_resistance ARO:3005318 OXA-543 ARO:3005318 OXA-543 OXA-681 is a beta-lactamase in the OXA-2 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-681 antibiotic_resistance ARO:3005319 OXA-681 ARO:3005319 OXA-681 OXA-737 is a beta-lactamase in the OXA-2 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-737 antibiotic_resistance ARO:3005320 OXA-737 ARO:3005320 OXA-737 OXA-541 is a beta-lactamase in the OXA-2 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-541 antibiotic_resistance ARO:3005321 OXA-541 ARO:3005321 OXA-541 OXA-835 is a beta-lactamase in the OXA-46 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-835 antibiotic_resistance ARO:3005322 OXA-835 ARO:3005322 OXA-835 OXA-926 is a class D beta-lactamase in the family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-926 antibiotic_resistance ARO:3005323 OXA-926 ARO:3005323 OXA-926 OXA-570 is a beta-lactamase in the OXA-60 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-570 antibiotic_resistance ARO:3005324 OXA-570 ARO:3005324 OXA-570 OXA-573 is a beta-lactamase in the OXA-60 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-573 antibiotic_resistance ARO:3005325 OXA-573 ARO:3005325 OXA-573 OXA-571 is a beta-lactamase in the OXA-60 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-571 antibiotic_resistance ARO:3005326 OXA-571 ARO:3005326 OXA-571 OXA-672 is a beta-lactamase in the OXA-286 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-672 antibiotic_resistance ARO:3005327 OXA-672 ARO:3005327 OXA-672 OXA-671 is a beta-lactamase in the OXA-286 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-671 antibiotic_resistance ARO:3005328 OXA-671 ARO:3005328 OXA-671 OXA-673 is a beta-lactamase in the OXA-286 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-673 antibiotic_resistance ARO:3005329 OXA-673 ARO:3005329 OXA-673 OXA-931 is a beta-lactamase in the OXA-229 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-931 antibiotic_resistance ARO:3005330 OXA-931 ARO:3005330 OXA-931 OXA-930 is a beta-lactamase in the OXA-229 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-930 antibiotic_resistance ARO:3005331 OXA-930 ARO:3005331 OXA-930 OXA-895 is a beta-lactamase in the OXA-229 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-895 antibiotic_resistance ARO:3005332 OXA-895 ARO:3005332 OXA-895 OXA-641 is a beta-lactamase in the OXA-372 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-641 antibiotic_resistance ARO:3005333 OXA-641 ARO:3005333 OXA-641 DfrA42 is a dihydrofolate reductase that confers resistant to Trimethoprim. DfrA42 DfrA42_TMP antibiotic_resistance ARO:3005334 Trimethoprim-resistant dihydrofolate reductase DfrA42 ARO:3005334 DfrA42 is a dihydrofolate reductase that confers resistant to Trimethoprim. PMID:33593833 DfrA42_TMP OXA-496 is a beta-lactamase in the OXA-134 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-496 antibiotic_resistance ARO:3005335 OXA-496 ARO:3005335 OXA-496 is a beta-lactamase in the OXA-134 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. PMID:30150791 OXA-496 OXA-915 is a beta-lactamase in the OXA-134 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-915 antibiotic_resistance ARO:3005336 OXA-915 ARO:3005336 OXA-915 OXA-647 is a beta-lactamase in the OXA-134 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-647 antibiotic_resistance ARO:3005337 OXA-647 ARO:3005337 OXA-647 OXA-648 is a beta-lactamase in the OXA-134 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-648 antibiotic_resistance ARO:3005338 OXA-648 ARO:3005338 OXA-648 OXA-646 is a beta-lactamase in the OXA-134 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-646 antibiotic_resistance ARO:3005339 OXA-646 ARO:3005339 OXA-646 OXA-649 is a beta-lactamase in the OXA-143 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-649 antibiotic_resistance ARO:3005340 OXA-649 ARO:3005340 OXA-649 OXA-897 is a beta-lactamase in the OXA-24 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-897 antibiotic_resistance ARO:3005341 OXA-897 ARO:3005341 OXA-897 OXA-653 is a beta-lactamase in the OXA-24 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-653 antibiotic_resistance ARO:3005342 OXA-653 ARO:3005342 OXA-653 OXA-499 is a beta-lactamase in the OXA-143 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-499 antibiotic_resistance ARO:3005343 OXA-499 ARO:3005343 OXA-499 is a beta-lactamase in the OXA-143 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. PMID:28264850 OXA-499 OXA-825 is a beta-lactamase in the OXA-143 family of OXA beta-lactamases that confers resistance to ampicillin and cephalothin. OXA-825 antibiotic_resistance ARO:3005344 OXA-825 ARO:3005344 OXA-825 DfrA43 is a dihydrofolate reductase that confers resistance to Trimethoprim. Originially described by Shi YZ et al, 2016, and isolated from Proteus penneri. DfrA43 DfrA43_TMP antibiotic_resistance ARO:3005345 Trimethoprim-resistant dihydrofolate reductase DfrA43 ARO:3005345 DfrA43 is a dihydrofolate reductase that confers resistance to Trimethoprim. Originially described by Shi YZ et al, 2016, and isolated from Proteus penneri. PMID:33593833 DfrA43_TMP DfrA34 is a dihydrofolate reductase that confers resistant to Trimethoprim. DfrA34 trimethoprim resistant dfra34 antibiotic_resistance ARO:3005346 DfrA34 ARO:3005346 DfrA34 is a dihydrofolate reductase that confers resistant to Trimethoprim. PMID:30202900 DfrA34 DfrA37 is a dihydrofolate reductase that confers resistant to Trimethoprim. DfrA37 trimethoprim resistant dihydrofolate reductase dfra37 antibiotic_resistance ARO:3005347 DfrA37 ARO:3005347 DfrA37 is a dihydrofolate reductase that confers resistant to Trimethoprim. PMID:32318052 DfrA37 DfrA36 is a dihydrofolate reductase that confers resistant to Trimethoprim. Originally described by Wuthrich et al., 2019, and isolated from Escherichia coli. DfrA36 trimethoprim-resistant dihydrofolate reductase DfrA36 antibiotic_resistance ARO:3005348 DfrA36 ARO:3005348 DfrA36 is a dihydrofolate reductase that confers resistant to Trimethoprim. Originally described by Wuthrich et al., 2019, and isolated from Escherichia coli. PMID:31068437 DfrA36 DfrA38 is a dihydrofolate reductase that confers resistant to Trimethoprim. DfrA38 trimethoprim-resistant dihydrofolate reductase DfrA38 antibiotic_resistance ARO:3005349 DfrA38 ARO:3005349 DfrA38 is a dihydrofolate reductase that confers resistant to Trimethoprim. PMID:32929451 DfrA38 DfrB9 is a dihydrofolate reductase that confers resistant to Trimethoprim. DfrB9 trimethoprim-resistant dihydrofolate reductase DfrB9 antibiotic_resistance ARO:3005350 DfrB9 ARO:3005350 DfrB9 is a dihydrofolate reductase that confers resistant to Trimethoprim. PMID:33214838 PMID:33924456 DfrB9 DfrA39 is a dihydrofolate reductase that confers resistant to Trimethoprim. DfrA39 trimethoprim-resistant dihydrofolate reductase DfrA39 antibiotic_resistance ARO:3005351 DfrA39 ARO:3005351 DfrA39 is a dihydrofolate reductase that confers resistant to Trimethoprim. PMID:34180526 DfrA39 Dfr22 is a dihydrofolate reductase that confers resistant to Trimethoprim. Originally detected by Grape et al., (2005) and isolated from Escherichia coli. dfr22 trimethoprim-resistance dihydrofolate reductase type 22 antibiotic_resistance ARO:3005354 dfr22 ARO:3005354 Dfr22 is a dihydrofolate reductase that confers resistant to Trimethoprim. Originally detected by Grape et al., (2005) and isolated from Escherichia coli. PMID:15715715 dfr22 Carbapenem-hydrolyzing class A beta-lactamase kpc-23 [Klebsiella pneumoniae] Accession: WP_111672911.1. KPC-23 antibiotic_resistance ARO:3005356 KPC-23 ARO:3005356 Carbapenem-hydrolyzing class A beta-lactamase kpc-23 [Klebsiella pneumoniae] Accession: WP_111672911.1. PMID:30928562 KPC-23 Carbapenem-hydrolyzing class A beta-lactamase kpc-25 [Klebsiella pneumoniae] Accession: WP_065419571.1. KPC-25 antibiotic_resistance ARO:3005357 KPC-25 ARO:3005357 KPC-25 Carbapenem-hydrolyzing class A beta-lactamase kpc-26 [Klebsiella pneumoniae] Accession: WP_068981634.1. KPC-26 antibiotic_resistance ARO:3005358 KPC-26 ARO:3005358 KPC-26 Carbapenem-hydrolyzing class A beta-lactamase kpc-27 [Klebsiella pneumoniae] Accession: WP_077064886.1. KPC-27 antibiotic_resistance ARO:3005359 KPC-27 ARO:3005359 KPC-27 Carbapenem-hydrolyzing class A beta-lactamase kpc-29 [Klebsiella pneumoniae] Accession: WP_096807439.1. KPC-29 antibiotic_resistance ARO:3005360 KPC-29 ARO:3005360 KPC-29 Inhibitor-resistant class A extended-spectrum beta-lactamase kpc-28 [Escherichia coli] Accession: WP_072081992.1. KPC-28 antibiotic_resistance ARO:3005361 KPC-28 ARO:3005361 Inhibitor-resistant class A extended-spectrum beta-lactamase kpc-28 [Escherichia coli] Accession: WP_072081992.1. PMID:31127297 KPC-28 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-31 [Klebsiella] Accession: WP_073668892.1. KPC-31 antibiotic_resistance ARO:3005362 KPC-31 ARO:3005362 KPC-31 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-32 [Klebsiella pneumoniae] Accession: WP_073800284.1. KPC-32 antibiotic_resistance ARO:3005363 KPC-32 ARO:3005363 KPC-32 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-30 [Klebsiella pneumoniae] Accession: WP_085562399.1. KPC-30 antibiotic_resistance ARO:3005364 KPC-30 ARO:3005364 KPC-30 Inhibitor-resistant class A extended-spectrum beta-lactamase kpc-33 [Klebsiella pneumoniae] Accession: WP_101140102.1. KPC-33 antibiotic_resistance ARO:3005365 KPC-33 ARO:3005365 KPC-33 Carbapenem-hydrolyzing class A beta-lactamase kpc-34 [Klebsiella pneumoniae] Accession: WP_109545044.1. KPC-34 antibiotic_resistance ARO:3005366 KPC-34 ARO:3005366 KPC-34 Carbapenem-hydrolyzing class A beta-lactamase kpc-35 [Klebsiella pneumoniae] Accession: WP_111273852.1. KPC-35 antibiotic_resistance ARO:3005367 KPC-35 ARO:3005367 KPC-35 Carbapenem-hydrolyzing class A beta-lactamase kpc-36 [Klebsiella pneumoniae] Accession: WP_114699267.1. KPC-36 antibiotic_resistance ARO:3005368 KPC-36 ARO:3005368 KPC-36 Carbapenem-hydrolyzing class A beta-lactamase kpc-37 [Klebsiella pneumoniae] Accession: WP_116786832.1. KPC-37 antibiotic_resistance ARO:3005369 KPC-37 ARO:3005369 KPC-37 Carbapenem-hydrolyzing class A beta-lactamase kpc-38 [Klebsiella pneumoniae] Accession: WP_123002101.1. KPC-38 antibiotic_resistance ARO:3005370 KPC-38 ARO:3005370 KPC-38 Carbapenem-hydrolyzing class A beta-lactamase kpc-39 [Klebsiella pneumoniae] Accession: WP_128268237.1. KPC-39 antibiotic_resistance ARO:3005371 KPC-39 ARO:3005371 KPC-39 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-40 [Enterobacter hormaechei] Accession: WP_115470049.1. KPC-40 antibiotic_resistance ARO:3005372 KPC-40 ARO:3005372 KPC-40 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-41 [Klebsiella pneumoniae] Accession: WP_148044419.1. KPC-41 antibiotic_resistance ARO:3005373 KPC-41 ARO:3005373 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-41 [Klebsiella pneumoniae] Accession: WP_148044419.1. PMID:31527032 KPC-41 Carbapenem-hydrolyzing class A beta-lactamase kpc-42 [Klebsiella pneumoniae] Accession: WP_136512070.1. KPC-42 antibiotic_resistance ARO:3005374 KPC-42 ARO:3005374 KPC-42 Carbapenem-hydrolyzing class A beta-lactamase kpc-43 [Klebsiella pneumoniae] Accession: WP_136512071.1. KPC-43 antibiotic_resistance ARO:3005375 KPC-43 ARO:3005375 KPC-43 Carbapenem-hydrolyzing class A beta-lactamase kpc-45 [Enterobacter cloacae] Accession: WP_148044420.1. KPC-45 antibiotic_resistance ARO:3005376 KPC-45 ARO:3005376 KPC-45 Inhibitor-resistant class A extended-spectrum beta-lactamase kpc-46 [Klebsiella pneumoniae] Accession: WP_148044421.1. KPC-46 antibiotic_resistance ARO:3005377 KPC-46 ARO:3005377 KPC-46 Carbapenem-hydrolyzing class A beta-lactamase kpc-49 [Escherichia coli] Accession: WP_197749402.1. KPC-49 antibiotic_resistance ARO:3005378 KPC-49 ARO:3005378 KPC-49 Inhibitor-resistant class A beta-lactamase kpc-50 [Klebsiella pneumoniae] Accession: WP_171476788.1. KPC-50 antibiotic_resistance ARO:3005379 KPC-50 ARO:3005379 KPC-50 Inhibitor-resistant class A extended-spectrum beta-lactamase kpc-51 [Klebsiella pneumoniae] Accession: WP_158208923.1. KPC-51 antibiotic_resistance ARO:3005380 KPC-51 ARO:3005380 KPC-51 Inhibitor-resistant class A extended-spectrum beta-lactamase kpc-52 [Klebsiella pneumoniae] Accession: WP_158208806.1. KPC-52 antibiotic_resistance ARO:3005381 KPC-52 ARO:3005381 KPC-52 Carbapenem-hydrolyzing class A beta-lactamase kpc-54 [Klebsiella pneumoniae] Accession: WP_160164839.1. KPC-54 antibiotic_resistance ARO:3005382 KPC-54 ARO:3005382 KPC-54 Carbapenem-hydrolyzing class A beta-lactamase kpc-55 [Klebsiella pneumoniae] Accession: WP_168247883.1. KPC-55 antibiotic_resistance ARO:3005383 KPC-55 ARO:3005383 KPC-55 Carbapenem-hydrolyzing class A beta-lactamase kpc-56 [Klebsiella pneumoniae] Accession: WP_087744800.1. KPC-56 antibiotic_resistance ARO:3005384 KPC-56 ARO:3005384 KPC-56 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase kpc-57 [Klebsiella pneumoniae] Accession: WP_171476789.1. KPC-57 antibiotic_resistance ARO:3005385 KPC-57 ARO:3005385 KPC-57 Disinfectants that can also interact with antimicrobial resistance mechanisms, e.g. molecule efflux, and thus are the targets of disinfectant resistance. antibiotic_resistance ARO:3005386 disinfecting agents and antiseptics ARO:3005386 AAK beta-lactamases are a group of class A beta-lactamases found in Klebsiella pneumoniae. antibiotic_resistance ARO:3005387 AAK beta-lactamase ARO:3005387 AFM beta-lactamases are class B1 beta-lactamases found in proteobacteria like Pseudomonas aeruginosa. antibiotic_resistance ARO:3005388 AFM beta-lactamase ARO:3005388 ALG11 beta-lactamases are class B3 beta-lactamases. antibiotic_resistance ARO:3005389 ALG11 beta-lactamase ARO:3005389 ALG6 beta-lactamases are class B3 beta-lactamases. antibiotic_resistance ARO:3005390 ALG6 beta-lactamases ARO:3005390 ALI beta-lactamases are class B1 beta-lactamases found in species of the Aliivibrio genus. antibiotic_resistance ARO:3005391 ALI beta-lactamase ARO:3005391 ANA beta-lactamases are class B1 beta-lactamases found in Anaeromyxobacter. antibiotic_resistance ARO:3005392 ANA beta-lactamase ARO:3005392 AXC beta-lactamases are class A beta-lactamase found in the Anaeromyxobacter genus. antibiotic_resistance ARO:3005393 AXC beta-lactamase ARO:3005393 BSU beta-lactamases are class D beta-lactamases found in Bacillus inaquosorum. antibiotic_resistance ARO:3005394 BSU beta-lactamase ARO:3005394 CAR beta-lactamases are class B3 beta-lactamases found in Pectobacterium atrosepticum. antibiotic_resistance ARO:3005395 CAR beta-lactamase ARO:3005395 CDD beta-lactamases are class D beta-lactamases found in Clostridioides difficile. antibiotic_resistance ARO:3005396 CDD beta-lactamase ARO:3005396 CMA beta-lactamases are class C beta-lactamases found in Cronobacter malonaticus. antibiotic_resistance ARO:3005397 CMA beta-lactamase ARO:3005397 CRD3 beta-lactamases are class B3 beta-lactamases. antibiotic_resistance ARO:3005398 CRD3 beta-lactamase ARO:3005398 CRH beta-lactamases are class A beta-lactamases found in Chromobacterium haemolyticum. antibiotic_resistance ARO:3005399 CRH beta-lactamase ARO:3005399 CRP beta-lactamases are class A beta-lactamase found in Chromobacterium piscinae. antibiotic_resistance ARO:3005400 CRP beta-lactamase ARO:3005400 CSA beta-lactamases are class C beta-lactamases found in Cronobacter sakazakii. antibiotic_resistance ARO:3005401 CSA beta-lactamase ARO:3005401 CSP beta-lactamases are class A beta-lactamases found in Capnocytophaga sputigena. antibiotic_resistance ARO:3005402 CSP beta-lactamase ARO:3005402 CVI beta-lactamases are a class B2 beta-lactamase found in Chromobacterium violaceum. antibiotic_resistance ARO:3005403 CVI beta-lactamase ARO:3005403 DHT2 beta-lactamases are class B3 beta-lactamases. antibiotic_resistance ARO:3005404 DHT2 beta-lactamase ARO:3005404 EAM beta-lactamase are class B3 beta-lactamases found in Qipengyuania aquimaris. antibiotic_resistance ARO:3005405 EAM beta-lactamase ARO:3005405 EC beta-lactamases are class C beta-lactamases found in Escherichia coli. antibiotic_resistance ARO:3005406 EC beta-lactamase ARO:3005406 ECM beta-lactamases are class B3 beta-lactamases found in Qipengyuania citrea. antibiotic_resistance ARO:3005407 ECM beta-lactamase ARO:3005407 ECV beta-lactamases are class B1 beta-lactamases found in Echinicola vietnamensis. antibiotic_resistance ARO:3005408 ECV beta-lactamase ARO:3005408 EFM beta-lactamases are class B3 beta-lactamase found in Qipengyuania flava. antibiotic_resistance ARO:3005409 EFM beta-lactamase ARO:3005409 ELM beta-lactamases are class B3 beta-lactamases found in Erythrobacter longus. antibiotic_resistance ARO:3005410 ELM beta-lactamase ARO:3005410 EVM beta-lactamases are class B3 beta-lactamases found in Qipengyuania vulgaris. antibiotic_resistance ARO:3005411 EVM beta-lactamase ARO:3005411 FIA beta-lactamases are class B1 beta-lactamases found in Fibrella aestuarina. antibiotic_resistance ARO:3005412 FIA beta-lactamase ARO:3005412 GIL-beta-lactamases are class A beta-lactamases found in Citrobacter gillenii. antibiotic_resistance ARO:3005413 GIL beta-lactamase ARO:3005413 GMB beta-lactamases are class B1 beta-lactamases found in Citrobacter freundii. antibiotic_resistance ARO:3005414 GMB beta-lactamase ARO:3005414 GRD23 beta-lactamases are class B1 beta-lactamases. antibiotic_resistance ARO:3005415 GRD23 beta-lactamase ARO:3005415 GRD33 beta-lactamases are class B3 beta-lactamase. antibiotic_resistance ARO:3005416 GRD33 beta-lactamase ARO:3005416 KLUC beta-lactamases are class A beta-lactamases found in Kluyvera cryocrescens, Escherichia coli and Enterobacteriaceae. antibiotic_resistance ARO:3005417 KLUC beta-lactamase ARO:3005417 LHK beta-lactamases are class C beta-lactamases found in Laribacter hongkongensis. antibiotic_resistance ARO:3005418 LHK beta-lactamase ARO:3005418 LRG beta-lactamases are class A beta-lactamases. antibiotic_resistance ARO:3005419 LRG beta-lactamase ARO:3005419 LUS beta-lactamases are class A beta-lactamases found in Pedobacter lusitanus. antibiotic_resistance ARO:3005420 LUS beta-lactamase ARO:3005420 LUT beta-lactamases are class A beta lactamases found in Pseudomonas luteola. antibiotic_resistance ARO:3005421 LUT beta-lactamase ARO:3005421 MAL beta-lactamase are class A beta-lactamases found in Citrobacter koseri. antibiotic_resistance ARO:3005422 MAL beta-lactamase ARO:3005422 MBL beta-lactamases are class B3 beta-lactamases found in Caulobacter vibrioides. antibiotic_resistance ARO:3005423 MBL beta-lactamase ARO:3005423 MOC beta-lactamases are class B1 beta-lactamase found in Myroides odoratus. antibiotic_resistance ARO:3005424 MOC beta-lactamase ARO:3005424 MOR beta-lactamases are class C beta-lactamases found in Morganella morganii. antibiotic_resistance ARO:3005425 MOR beta-lactamase ARO:3005425 MYO beta-lactamases are class B1 beta-lactamases found in Myroides odoratimimus. antibiotic_resistance ARO:3005426 MYO beta-lactamase ARO:3005426 MYX beta-lactamases are class B1 beta-lactamases found in Myxococcus. antibiotic_resistance ARO:3005427 MYX beta-lactamase ARO:3005427 OHIO beta-lactamases are class A beta-lactamases. antibiotic_resistance ARO:3005428 OHIO beta-lactamase ARO:3005428 ORN beta-lactamases are class A beta-lactamases found in Raoultella ornithinolytica. antibiotic_resistance ARO:3005429 ORN beta-lactamase ARO:3005429 ORR beta-lactamases are class B1 beta-lactamases found in Ornithobacterium rhinotracheale. antibiotic_resistance ARO:3005430 ORR beta-lactamase ARO:3005430 PAU beta-lactamases are class A beta-lactamases found in Pseudomonas aeruginosa. antibiotic_resistance ARO:3005431 PAU beta-lactamase ARO:3005431 PFM beta-lactamases are class B2 beta-lactamases found in Pseudomonas fluorescens. antibiotic_resistance ARO:3005432 PFM beta-lactamase ARO:3005432 PLA beta-lactamases are class A beta-lactamase found in Raoultella planticola. antibiotic_resistance ARO:3005433 PLA beta-lactamase ARO:3005433 PLN beta-lactamases are class B3 beta-lactamases found in Pedobacter lusitanus. antibiotic_resistance ARO:3005434 PLN beta-lactamase ARO:3005434 PME beta-lactamases are class A beta-lactamases found in Gammaproteobacteria. antibiotic_resistance ARO:3005435 PME beta-lactamase ARO:3005435 POM beta-lactamases are class B3 beta-lactamases found in Pseudomonas otitidis. antibiotic_resistance ARO:3005436 POM beta-lactamase ARO:3005436 PST bea-lactamases are class B1 beta-lactamases found in Pseudomonas stutzeri. antibiotic_resistance ARO:3005437 PST beta-lactamase ARO:3005437 PSV beta-lactamases are class A beta-lactamases found in Pseudovibrio. antibiotic_resistance ARO:3005438 PSV beta-lactamase ARO:3005438 RAHN beta-lactamases are class A beta-lactamases found in Rahnella aquatilis. antibiotic_resistance ARO:3005439 RAHN beta-lactamase ARO:3005439 RSA2 beta-lactamases are class A beta-lactamases. antibiotic_resistance ARO:3005440 RSA2 beta-lactamase ARO:3005440 RSD2 beta-lactamases are class D beta-lactamases. antibiotic_resistance ARO:3005441 RSD2 beta-lactamase ARO:3005441 RUB beta-lactamases are class A beta-lactamases found in Serratia rubidaea. antibiotic_resistance ARO:3005442 RUB beta-lactamase ARO:3005442 SFC beta-lactamases are class A beta-lactamases found in Serratia fonticola. antibiotic_resistance ARO:3005443 SFC beta-lactamase ARO:3005443 SFO beta-lactamases are class A beta-lactamases found in Gammaproteobacteria. antibiotic_resistance ARO:3005444 SFO beta-lactamase ARO:3005444 SGM beta-lactamases are class A beta-lactamases found in members of the Sphingobium genus. antibiotic_resistance ARO:3005445 SGM beta-lactamase ARO:3005445 SHN beta-lactamases are class B1 beta-lactamases found in Shewanella denitrificans. antibiotic_resistance ARO:3005446 SHN beta-lactamase ARO:3005446 SPN beta-lactamases are class B1 beta-lactamases. antibiotic_resistance ARO:3005447 SPN79 beta-lactamase ARO:3005447 SPR beta-lactamases are class B beta-lactamases found in Serratia proteamaculans. antibiotic_resistance ARO:3005448 SPR beta-lactamase ARO:3005448 SPS beta-lactamases are class B1 beta lactamases found in Sediminispirochaeta smaragdinae. antibiotic_resistance ARO:3005449 SPS beta-lactamase ARO:3005449 SPU beta-lactamases are class A beta-lactamases found in Capnocytophaga sputigena. antibiotic_resistance ARO:3005450 SPU beta-lactamase ARO:3005450 SST beta-lactamases are class C beta-lactamases found in Serratia marcescens. antibiotic_resistance ARO:3005451 SST beta-lactamase ARO:3005451 STA beta-lactamases are class B1 beta-lactamases found in Stigmatella aurantiaca. antibiotic_resistance ARO:3005452 STA beta-lactamase ARO:3005452 TER beta-lactamases are class A beta-lactamases found in Raoultella terrigena. antibiotic_resistance ARO:3005453 TER beta-lactamase ARO:3005453 TTU beta-lactamases are class B1 beta-lactamases found in Teredinibacter turnerae. antibiotic_resistance ARO:3005454 TTU beta-lactamase ARO:3005454 VHH beta-lactamases are class A beta-lactamases found in Vibrio harveyi. antibiotic_resistance ARO:3005455 VHH beta-lactamase ARO:3005455 VHW beta-lactamases are class A beta-lactamases found Vibrio harveyi. antibiotic_resistance ARO:3005456 VHW beta-lactamase ARO:3005456 YEM beta-lactamases are class B2 beta-lactamases found in Yersinia mollaretii. antibiotic_resistance ARO:3005457 YEM beta-lactamase ARO:3005457 ZOG beta-lactamases are class B1 beta-lactamases found in Zobellia galactanivorans. antibiotic_resistance ARO:3005458 ZOG beta-lactamase ARO:3005458 ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins and may or may not cause resistance to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis. antibiotic_resistance ARO:3005459 ADC beta-lactamase ARO:3005459 ADC beta-lactamases with undetermined carbapenemase activity. antibiotic_resistance ARO:3005460 ADC beta-lactamases pending classification for carbapenemase activity ARO:3005460 EBR-3 is a EBR beta-lactamase. EBR-3 antibiotic_resistance ARO:3005461 EBR-3 ARO:3005461 EBR-3 EBR-4 is a EBR beta-lactamase. EBR-4 antibiotic_resistance ARO:3005462 EBR-4 ARO:3005462 EBR-4 IMP-53 is a IMP beta-lactamase. IMP-53 antibiotic_resistance ARO:3005463 IMP-53 ARO:3005463 IMP-53 IMP-54 is a IMP beta-lactamase. IMP-54 antibiotic_resistance ARO:3005464 IMP-54 ARO:3005464 IMP-54 IMP-58 is a IMP beta-lactamase. IMP-58 antibiotic_resistance ARO:3005465 IMP-58 ARO:3005465 IMP-58 IMP-59 is a IMP beta-lactamase. IMP-59 antibiotic_resistance ARO:3005466 IMP-59 ARO:3005466 IMP-59 IMP-60 is a IMP beta-lactamase. IMP-60 antibiotic_resistance ARO:3005467 IMP-60 ARO:3005467 IMP-60 IMP-61 is a IMP beta-lactamase. IMP-61 antibiotic_resistance ARO:3005468 IMP-61 ARO:3005468 IMP-61 IMP-62 is a IMP beta-lactamase. IMP-62 antibiotic_resistance ARO:3005469 IMP-62 ARO:3005469 IMP-62 IMP-63 is a IMP beta-lactamase. IMP-63 antibiotic_resistance ARO:3005470 IMP-63 ARO:3005470 IMP-63 IMP-64 is a IMP beta-lactamase. IMP-64 antibiotic_resistance ARO:3005471 IMP-64 ARO:3005471 IMP-64 IMP-65 is a IMP beta-lactamase. IMP-65 antibiotic_resistance ARO:3005472 IMP-65 ARO:3005472 IMP-65 IMP-66 is a IMP beta-lactamase. IMP-66 antibiotic_resistance ARO:3005473 IMP-66 ARO:3005473 IMP-66 IMP-67 is a IMP beta-lactamase. IMP-67 antibiotic_resistance ARO:3005474 IMP-67 ARO:3005474 IMP-67 IMP-69 is a IMP beta-lactamase. IMP-69 antibiotic_resistance ARO:3005475 IMP-69 ARO:3005475 IMP-69 IMP-70 is a IMP beta-lactamase. IMP-70 antibiotic_resistance ARO:3005476 IMP-70 ARO:3005476 IMP-70 IMP-71 is a IMP beta-lactamase. IMP-71 antibiotic_resistance ARO:3005477 IMP-71 ARO:3005477 IMP-71 IMP-73 is a IMP beta-lactamase. IMP-73 antibiotic_resistance ARO:3005478 IMP-73 ARO:3005478 IMP-73 IMP-74 is a IMP beta-lactamase. IMP-74 antibiotic_resistance ARO:3005479 IMP-74 ARO:3005479 IMP-74 IMP-75 is a IMP beta-lactamase. IMP-75 antibiotic_resistance ARO:3005480 IMP-75 ARO:3005480 IMP-75 IMP-76 is a IMP beta-lactamase. IMP-76 antibiotic_resistance ARO:3005481 IMP-76 ARO:3005481 IMP-76 IMP-77 is a IMP beta-lactamase. IMP-77 antibiotic_resistance ARO:3005482 IMP-77 ARO:3005482 IMP-77 IMP-78 is a IMP beta-lactamase. IMP-78 antibiotic_resistance ARO:3005483 IMP-78 ARO:3005483 IMP-78 IMP-79 is a IMP beta-lactamase. IMP-79 antibiotic_resistance ARO:3005484 IMP-79 ARO:3005484 IMP-79 IMP-80 is a IMP beta-lactamase. IMP-80 antibiotic_resistance ARO:3005485 IMP-80 ARO:3005485 IMP-80 IMP-81 is a IMP beta-lactamase. IMP-81 antibiotic_resistance ARO:3005486 IMP-81 ARO:3005486 IMP-81 IMP-82 is a IMP beta-lactamase. IMP-82 antibiotic_resistance ARO:3005487 IMP-82 ARO:3005487 IMP-82 IMP-83 is a IMP beta-lactamase. IMP-83 antibiotic_resistance ARO:3005488 IMP-83 ARO:3005488 IMP-83 IMP-84 is a IMP beta-lactamase. IMP-84 antibiotic_resistance ARO:3005489 IMP-84 ARO:3005489 IMP-84 IMP-85 is a IMP beta-lactamase. IMP-85 antibiotic_resistance ARO:3005490 IMP-85 ARO:3005490 IMP-85 IMP-88 is a IMP beta-lactamase. IMP-88 antibiotic_resistance ARO:3005491 IMP-88 ARO:3005491 IMP-88 IMP-89 is a IMP beta-lactamase. IMP-89 antibiotic_resistance ARO:3005492 IMP-89 ARO:3005492 IMP-89 IND-16 is a IND beta-lactamase. IND-16 antibiotic_resistance ARO:3005493 IND-16 ARO:3005493 IND-16 SIM-2 is a SIM beta-lactamase. SIM-2 antibiotic_resistance ARO:3005494 SIM-2 ARO:3005494 SIM-2 VIM-47 is a VIM beta-lactamase. VIM-47 antibiotic_resistance ARO:3005495 VIM-47 ARO:3005495 VIM-47 VIM-48 is a VIM beta-lactamase. VIM-48 antibiotic_resistance ARO:3005496 VIM-48 ARO:3005496 VIM-48 VIM-49 is a VIM beta-lactamase. VIM-49 antibiotic_resistance ARO:3005497 VIM-49 ARO:3005497 VIM-49 VIM-50 is a VIM beta-lactamase. VIM-50 antibiotic_resistance ARO:3005498 VIM-50 ARO:3005498 VIM-50 VIM-51 is a VIM beta-lactamase. VIM-51 antibiotic_resistance ARO:3005499 VIM-51 ARO:3005499 VIM-51 VIM-52 is a VIM beta-lactamase. VIM-52 antibiotic_resistance ARO:3005500 VIM-52 ARO:3005500 VIM-52 VIM-53 is a VIM beta-lactamase. VIM-53 antibiotic_resistance ARO:3005501 VIM-53 ARO:3005501 VIM-53 VIM-54 is a VIM beta-lactamase. VIM-54 antibiotic_resistance ARO:3005502 VIM-54 ARO:3005502 VIM-54 VIM-55 is a VIM beta-lactamase. VIM-55 antibiotic_resistance ARO:3005503 VIM-55 ARO:3005503 VIM-55 VIM-56 is a VIM beta-lactamase. VIM-56 antibiotic_resistance ARO:3005504 VIM-56 ARO:3005504 VIM-56 VIM-57 is a VIM beta-lactamase. VIM-57 antibiotic_resistance ARO:3005505 VIM-57 ARO:3005505 VIM-57 VIM-58 is a VIM beta-lactamase. VIM-58 antibiotic_resistance ARO:3005506 VIM-58 ARO:3005506 VIM-58 VIM-59 is a VIM beta-lactamase. VIM-59 antibiotic_resistance ARO:3005507 VIM-59 ARO:3005507 VIM-59 VIM-60 is a VIM beta-lactamase. VIM-60 antibiotic_resistance ARO:3005508 VIM-60 ARO:3005508 VIM-60 VIM-61 is a VIM beta-lactamase. VIM-61 antibiotic_resistance ARO:3005509 VIM-61 ARO:3005509 VIM-61 VIM-62 is a VIM beta-lactamase. VIM-62 antibiotic_resistance ARO:3005510 VIM-62 ARO:3005510 VIM-62 VIM-63 is a VIM beta-lactamase. VIM-63 antibiotic_resistance ARO:3005511 VIM-63 ARO:3005511 VIM-63 VIM-64 is a VIM beta-lactamase. VIM-64 antibiotic_resistance ARO:3005512 VIM-64 ARO:3005512 VIM-64 VIM-65 is a VIM beta-lactamase. VIM-65 antibiotic_resistance ARO:3005513 VIM-65 ARO:3005513 VIM-65 VIM-66 is a VIM beta-lactamase. VIM-66 antibiotic_resistance ARO:3005514 VIM-66 ARO:3005514 VIM-66 VIM-67 is a VIM beta-lactamase. VIM-67 antibiotic_resistance ARO:3005515 VIM-67 ARO:3005515 VIM-67 VIM-68 is a VIM beta-lactamase. VIM-68 antibiotic_resistance ARO:3005516 VIM-68 ARO:3005516 VIM-68 VIM-69 is a VIM beta-lactamase. VIM-69 antibiotic_resistance ARO:3005517 VIM-69 ARO:3005517 VIM-69 VIM-70 is a VIM beta-lactamase. VIM-70 antibiotic_resistance ARO:3005518 VIM-70 ARO:3005518 VIM-70 VIM-71 is a VIM beta-lactamase. VIM-71 antibiotic_resistance ARO:3005519 VIM-71 ARO:3005519 VIM-71 VIM-72 is a VIM beta-lactamase. VIM-72 antibiotic_resistance ARO:3005520 VIM-72 ARO:3005520 VIM-72 VIM-73 is a VIM beta-lactamase. VIM-73 antibiotic_resistance ARO:3005521 VIM-73 ARO:3005521 VIM-73 BlaB-1 is a BlaB beta-lactamase. BlaB-1 antibiotic_resistance ARO:3005522 BlaB-1 ARO:3005522 BlaB-1 BlaB-10 is a BlaB beta-lactamase. BlaB-10 antibiotic_resistance ARO:3005523 BlaB-10 ARO:3005523 BlaB-10 BlaB-11 is a BlaB beta-lactamase. BlaB-11 antibiotic_resistance ARO:3005524 BlaB-11 ARO:3005524 BlaB-11 BlaB-12 is a BlaB beta-lactamase. BlaB-12 antibiotic_resistance ARO:3005525 BlaB-12 ARO:3005525 BlaB-12 BlaB-13 is a BlaB beta-lactamase. BlaB-13 antibiotic_resistance ARO:3005526 BlaB-13 ARO:3005526 BlaB-13 BlaB-14 is a BlaB beta-lactamase. BlaB-14 antibiotic_resistance ARO:3005527 BlaB-14 ARO:3005527 BlaB-14 BlaB-15 is a BlaB beta-lactamase. BlaB-15 antibiotic_resistance ARO:3005528 BlaB-15 ARO:3005528 BlaB-15 BlaB-16 is a BlaB beta-lactamase. BlaB-16 antibiotic_resistance ARO:3005529 BlaB-16 ARO:3005529 BlaB-16 BlaB-17 is a BlaB beta-lactamase. BlaB-17 antibiotic_resistance ARO:3005530 BlaB-17 ARO:3005530 BlaB-17 BlaB-18 is a BlaB beta-lactamase. BlaB-18 antibiotic_resistance ARO:3005531 BlaB-18 ARO:3005531 BlaB-18 BlaB-19 is a BlaB beta-lactamase. BlaB-19 antibiotic_resistance ARO:3005532 BlaB-19 ARO:3005532 BlaB-19 BlaB-2 is a BlaB beta-lactamase. BlaB-2 antibiotic_resistance ARO:3005533 BlaB-2 ARO:3005533 BlaB-2 BlaB-20 is a BlaB beta-lactamase. BlaB-20 antibiotic_resistance ARO:3005534 BlaB-20 ARO:3005534 BlaB-20 BlaB-22 is a BlaB beta-lactamase. BlaB-22 antibiotic_resistance ARO:3005535 BlaB-22 ARO:3005535 BlaB-22 BlaB-23 is a BlaB beta-lactamase. BlaB-23 antibiotic_resistance ARO:3005536 BlaB-23 ARO:3005536 BlaB-23 BlaB-24 is a BlaB beta-lactamase. BlaB-24 antibiotic_resistance ARO:3005537 BlaB-24 ARO:3005537 BlaB-24 BlaB-25 is a BlaB beta-lactamase. BlaB-25 antibiotic_resistance ARO:3005538 BlaB-25 ARO:3005538 BlaB-25 BlaB-26 is a BlaB beta-lactamase. BlaB-26 antibiotic_resistance ARO:3005539 BlaB-26 ARO:3005539 BlaB-26 BlaB-27 is a BlaB beta-lactamase. BlaB-27 antibiotic_resistance ARO:3005540 BlaB-27 ARO:3005540 BlaB-27 BlaB-28 is a BlaB beta-lactamase. BlaB-28 antibiotic_resistance ARO:3005541 BlaB-28 ARO:3005541 BlaB-28 BlaB-29 is a BlaB beta-lactamase. BlaB-29 antibiotic_resistance ARO:3005542 BlaB-29 ARO:3005542 BlaB-29 BlaB-3 is a BlaB beta-lactamase. BlaB-3 antibiotic_resistance ARO:3005543 BlaB-3 ARO:3005543 BlaB-3 BlaB-30 is a BlaB beta-lactamase. BlaB-30 antibiotic_resistance ARO:3005544 BlaB-30 ARO:3005544 BlaB-30 BlaB-31 is a BlaB beta-lactamase. BlaB-31 antibiotic_resistance ARO:3005545 BlaB-31 ARO:3005545 BlaB-31 BlaB-32 is a BlaB beta-lactamase. BlaB-32 antibiotic_resistance ARO:3005546 BlaB-32 ARO:3005546 BlaB-32 BlaB-33 is a BlaB beta-lactamase. BlaB-33 antibiotic_resistance ARO:3005547 BlaB-33 ARO:3005547 BlaB-33 BlaB-34 is a BlaB beta-lactamase. BlaB-34 antibiotic_resistance ARO:3005548 BlaB-34 ARO:3005548 BlaB-34 BlaB-35 is a BlaB beta-lactamase. BlaB-35 antibiotic_resistance ARO:3005549 BlaB-35 ARO:3005549 BlaB-35 BlaB-36 is a BlaB beta-lactamase. BlaB-36 antibiotic_resistance ARO:3005550 BlaB-36 ARO:3005550 BlaB-36 BlaB-38 is a BlaB beta-lactamase. BlaB-38 antibiotic_resistance ARO:3005551 BlaB-38 ARO:3005551 BlaB-38 BlaB-39 is a BlaB beta-lactamase. BlaB-39 antibiotic_resistance ARO:3005552 BlaB-39 ARO:3005552 BlaB-39 BlaB-5 is a BlaB beta-lactamase. BlaB-5 antibiotic_resistance ARO:3005553 BlaB-5 ARO:3005553 BlaB-5 BlaB-6 is a BlaB beta-lactamase. BlaB-6 antibiotic_resistance ARO:3005554 BlaB-6 ARO:3005554 BlaB-6 BlaB-7 is a BlaB beta-lactamase. BlaB-7 antibiotic_resistance ARO:3005555 BlaB-7 ARO:3005555 BlaB-7 BlaB-8 is a BlaB beta-lactamase. BlaB-8 antibiotic_resistance ARO:3005556 BlaB-8 ARO:3005556 BlaB-8 BlaB-9 is a BlaB beta-lactamase. BlaB-9 antibiotic_resistance ARO:3005557 BlaB-9 ARO:3005557 BlaB-9 BUT-2 is a BUT beta-lactamase. BUT-2 antibiotic_resistance ARO:3005558 BUT-2 ARO:3005558 BUT-2 CARB-11 is a CARB beta-lactamase. CARB-11 antibiotic_resistance ARO:3005559 CARB-11 ARO:3005559 CARB-11 CARB-24 is a CARB beta-lactamase. CARB-24 antibiotic_resistance ARO:3005560 CARB-24 ARO:3005560 CARB-24 CARB-25 is a CARB beta-lactamase. CARB-25 antibiotic_resistance ARO:3005561 CARB-25 ARO:3005561 CARB-25 CARB-26 is a CARB beta-lactamase. CARB-26 antibiotic_resistance ARO:3005562 CARB-26 ARO:3005562 CARB-26 CARB-27 is a CARB beta-lactamase. CARB-27 antibiotic_resistance ARO:3005563 CARB-27 ARO:3005563 CARB-27 CARB-28 is a CARB beta-lactamase. CARB-28 antibiotic_resistance ARO:3005564 CARB-28 ARO:3005564 CARB-28 CARB-29 is a CARB beta-lactamase. CARB-29 antibiotic_resistance ARO:3005565 CARB-29 ARO:3005565 CARB-29 CARB-30 is a CARB beta-lactamase. CARB-30 antibiotic_resistance ARO:3005566 CARB-30 ARO:3005566 CARB-30 CARB-31 is a CARB beta-lactamase. CARB-31 antibiotic_resistance ARO:3005567 CARB-31 ARO:3005567 CARB-31 CARB-32 is a CARB beta-lactamase. CARB-32 antibiotic_resistance ARO:3005568 CARB-32 ARO:3005568 CARB-32 CARB-33 is a CARB beta-lactamase. CARB-33 antibiotic_resistance ARO:3005569 CARB-33 ARO:3005569 CARB-33 CARB-34 is a CARB beta-lactamase. CARB-34 antibiotic_resistance ARO:3005570 CARB-34 ARO:3005570 CARB-34 CARB-35 is a CARB beta-lactamase. CARB-35 antibiotic_resistance ARO:3005571 CARB-35 ARO:3005571 CARB-35 CARB-36 is a CARB beta-lactamase. CARB-36 antibiotic_resistance ARO:3005572 CARB-36 ARO:3005572 CARB-36 CARB-38 is a CARB beta-lactamase. CARB-38 antibiotic_resistance ARO:3005573 CARB-38 ARO:3005573 CARB-38 CARB-40 is a CARB beta-lactamase. CARB-40 antibiotic_resistance ARO:3005574 CARB-40 ARO:3005574 CARB-40 CARB-41 is a CARB beta-lactamase. CARB-41 antibiotic_resistance ARO:3005575 CARB-41 ARO:3005575 CARB-41 CARB-42 is a CARB beta-lactamase. CARB-42 antibiotic_resistance ARO:3005576 CARB-42 ARO:3005576 CARB-42 CARB-43 is a CARB beta-lactamase. CARB-43 antibiotic_resistance ARO:3005577 CARB-43 ARO:3005577 CARB-43 CARB-44 is a CARB beta-lactamase. CARB-44 antibiotic_resistance ARO:3005578 CARB-44 ARO:3005578 CARB-44 CARB-45 is a CARB beta-lactamase. CARB-45 antibiotic_resistance ARO:3005579 CARB-45 ARO:3005579 CARB-45 CARB-46 is a CARB beta-lactamase. CARB-46 antibiotic_resistance ARO:3005580 CARB-46 ARO:3005580 CARB-46 CARB-47 is a CARB beta-lactamase. CARB-47 antibiotic_resistance ARO:3005581 CARB-47 ARO:3005581 CARB-47 CARB-48 is a CARB beta-lactamase. CARB-48 antibiotic_resistance ARO:3005582 CARB-48 ARO:3005582 CARB-48 CARB-49 is a CARB beta-lactamase. CARB-49 antibiotic_resistance ARO:3005583 CARB-49 ARO:3005583 CARB-49 CARB-50 is a CARB beta-lactamase. CARB-50 antibiotic_resistance ARO:3005584 CARB-50 ARO:3005584 CARB-50 CARB-51 is a CARB beta-lactamase. CARB-51 antibiotic_resistance ARO:3005585 CARB-51 ARO:3005585 CARB-51 CARB-52 is a CARB beta-lactamase. CARB-52 antibiotic_resistance ARO:3005586 CARB-52 ARO:3005586 CARB-52 CARB-53 is a CARB beta-lactamase. CARB-53 antibiotic_resistance ARO:3005587 CARB-53 ARO:3005587 CARB-53 CARB-54 is a CARB beta-lactamase. CARB-54 antibiotic_resistance ARO:3005588 CARB-54 ARO:3005588 CARB-54 CARB-55 is a CARB beta-lactamase. CARB-55 antibiotic_resistance ARO:3005589 CARB-55 ARO:3005589 CARB-55 CTX-M-167 is a CTX-M beta-lactamase. CTX-M-167 antibiotic_resistance ARO:3005590 CTX-M-167 ARO:3005590 CTX-M-167 CTX-M-168 is a CTX-M beta-lactamase. CTX-M-168 antibiotic_resistance ARO:3005591 CTX-M-168 ARO:3005591 CTX-M-168 CTX-M-169 is a CTX-M beta-lactamase. CTX-M-169 antibiotic_resistance ARO:3005592 CTX-M-169 ARO:3005592 CTX-M-169 CTX-M-170 is a CTX-M beta-lactamase. CTX-M-170 antibiotic_resistance ARO:3005593 CTX-M-170 ARO:3005593 CTX-M-170 CTX-M-171 is a CTX-M beta-lactamase. CTX-M-171 antibiotic_resistance ARO:3005594 CTX-M-171 ARO:3005594 CTX-M-171 CTX-M-172 is a CTX-M beta-lactamase. CTX-M-172 antibiotic_resistance ARO:3005595 CTX-M-172 ARO:3005595 CTX-M-172 CTX-M-173 is a CTX-M beta-lactamase. CTX-M-173 antibiotic_resistance ARO:3005596 CTX-M-173 ARO:3005596 CTX-M-173 CTX-M-174 is a CTX-M beta-lactamase. CTX-M-174 antibiotic_resistance ARO:3005597 CTX-M-174 ARO:3005597 CTX-M-174 CTX-M-175 is a CTX-M beta-lactamase. CTX-M-175 antibiotic_resistance ARO:3005598 CTX-M-175 ARO:3005598 CTX-M-175 CTX-M-176 is a CTX-M beta-lactamase. CTX-M-176 antibiotic_resistance ARO:3005599 CTX-M-176 ARO:3005599 CTX-M-176 CTX-M-177 is a CTX-M beta-lactamase. CTX-M-177 antibiotic_resistance ARO:3005600 CTX-M-177 ARO:3005600 CTX-M-177 CTX-M-178 is a CTX-M beta-lactamase. CTX-M-178 antibiotic_resistance ARO:3005601 CTX-M-178 ARO:3005601 CTX-M-178 CTX-M-179 is a CTX-M beta-lactamase. CTX-M-179 antibiotic_resistance ARO:3005602 CTX-M-179 ARO:3005602 CTX-M-179 CTX-M-180 is a CTX-M beta-lactamase. CTX-M-180 antibiotic_resistance ARO:3005603 CTX-M-180 ARO:3005603 CTX-M-180 CTX-M-181 is a CTX-M beta-lactamase. CTX-M-181 antibiotic_resistance ARO:3005604 CTX-M-181 ARO:3005604 CTX-M-181 CTX-M-182 is a CTX-M beta-lactamase. CTX-M-182 antibiotic_resistance ARO:3005605 CTX-M-182 ARO:3005605 CTX-M-182 CTX-M-183 is a CTX-M beta-lactamase. CTX-M-183 antibiotic_resistance ARO:3005606 CTX-M-183 ARO:3005606 CTX-M-183 CTX-M-184 is a CTX-M beta-lactamase. CTX-M-184 antibiotic_resistance ARO:3005607 CTX-M-184 ARO:3005607 CTX-M-184 CTX-M-185 is a CTX-M beta-lactamase. CTX-M-185 antibiotic_resistance ARO:3005608 CTX-M-185 ARO:3005608 CTX-M-185 CTX-M-186 is a CTX-M beta-lactamase. CTX-M-186 antibiotic_resistance ARO:3005609 CTX-M-186 ARO:3005609 CTX-M-186 CTX-M-187 is a CTX-M beta-lactamase. CTX-M-187 antibiotic_resistance ARO:3005610 CTX-M-187 ARO:3005610 CTX-M-187 CTX-M-188 is a CTX-M beta-lactamase. CTX-M-188 antibiotic_resistance ARO:3005611 CTX-M-188 ARO:3005611 CTX-M-188 CTX-M-189 is a CTX-M beta-lactamase. CTX-M-189 antibiotic_resistance ARO:3005612 CTX-M-189 ARO:3005612 CTX-M-189 CTX-M-190 is a CTX-M beta-lactamase. CTX-M-190 antibiotic_resistance ARO:3005613 CTX-M-190 ARO:3005613 CTX-M-190 CTX-M-191 is a CTX-M beta-lactamase. CTX-M-191 antibiotic_resistance ARO:3005614 CTX-M-191 ARO:3005614 CTX-M-191 CTX-M-192 is a CTX-M beta-lactamase. CTX-M-192 antibiotic_resistance ARO:3005615 CTX-M-192 ARO:3005615 CTX-M-192 CTX-M-193 is a CTX-M beta-lactamase. CTX-M-193 antibiotic_resistance ARO:3005616 CTX-M-193 ARO:3005616 CTX-M-193 CTX-M-194 is a CTX-M beta-lactamase. CTX-M-194 antibiotic_resistance ARO:3005617 CTX-M-194 ARO:3005617 CTX-M-194 CTX-M-195 is a CTX-M beta-lactamase. CTX-M-195 antibiotic_resistance ARO:3005618 CTX-M-195 ARO:3005618 CTX-M-195 CTX-M-196 is a CTX-M beta-lactamase. CTX-M-196 antibiotic_resistance ARO:3005619 CTX-M-196 ARO:3005619 CTX-M-196 CTX-M-197 is a CTX-M beta-lactamase. CTX-M-197 antibiotic_resistance ARO:3005620 CTX-M-197 ARO:3005620 CTX-M-197 CTX-M-198 is a CTX-M beta-lactamase. CTX-M-198 antibiotic_resistance ARO:3005621 CTX-M-198 ARO:3005621 CTX-M-198 CTX-M-199 is a CTX-M beta-lactamase. CTX-M-199 antibiotic_resistance ARO:3005622 CTX-M-199 ARO:3005622 CTX-M-199 CTX-M-200 is a CTX-M beta-lactamase. CTX-M-200 antibiotic_resistance ARO:3005623 CTX-M-200 ARO:3005623 CTX-M-200 CTX-M-201 is a CTX-M beta-lactamase. CTX-M-201 antibiotic_resistance ARO:3005624 CTX-M-201 ARO:3005624 CTX-M-201 CTX-M-202 is a CTX-M beta-lactamase. CTX-M-202 antibiotic_resistance ARO:3005625 CTX-M-202 ARO:3005625 CTX-M-202 CTX-M-203 is a CTX-M beta-lactamase. CTX-M-203 antibiotic_resistance ARO:3005626 CTX-M-203 ARO:3005626 CTX-M-203 CTX-M-204 is a CTX-M beta-lactamase. CTX-M-204 antibiotic_resistance ARO:3005627 CTX-M-204 ARO:3005627 CTX-M-204 CTX-M-205 is a CTX-M beta-lactamase. CTX-M-205 antibiotic_resistance ARO:3005628 CTX-M-205 ARO:3005628 CTX-M-205 CTX-M-206 is a CTX-M beta-lactamase. CTX-M-206 antibiotic_resistance ARO:3005629 CTX-M-206 ARO:3005629 CTX-M-206 CTX-M-207 is a CTX-M beta-lactamase. CTX-M-207 antibiotic_resistance ARO:3005630 CTX-M-207 ARO:3005630 CTX-M-207 CTX-M-208 is a CTX-M beta-lactamase. CTX-M-208 antibiotic_resistance ARO:3005631 CTX-M-208 ARO:3005631 CTX-M-208 CTX-M-209 is a CTX-M beta-lactamase. CTX-M-209 antibiotic_resistance ARO:3005632 CTX-M-209 ARO:3005632 CTX-M-209 CTX-M-210 is a CTX-M beta-lactamase. CTX-M-210 antibiotic_resistance ARO:3005633 CTX-M-210 ARO:3005633 CTX-M-210 CTX-M-211 is a CTX-M beta-lactamase. CTX-M-211 antibiotic_resistance ARO:3005634 CTX-M-211 ARO:3005634 CTX-M-211 CTX-M-212 is a CTX-M beta-lactamase. CTX-M-212 antibiotic_resistance ARO:3005635 CTX-M-212 ARO:3005635 CTX-M-212 CTX-M-213 is a CTX-M beta-lactamase. CTX-M-213 antibiotic_resistance ARO:3005636 CTX-M-213 ARO:3005636 CTX-M-213 CTX-M-214 is a CTX-M beta-lactamase. CTX-M-214 antibiotic_resistance ARO:3005637 CTX-M-214 ARO:3005637 CTX-M-214 CTX-M-215 is a CTX-M beta-lactamase. CTX-M-215 antibiotic_resistance ARO:3005638 CTX-M-215 ARO:3005638 CTX-M-215 CTX-M-216 is a CTX-M beta-lactamase. CTX-M-216 antibiotic_resistance ARO:3005639 CTX-M-216 ARO:3005639 CTX-M-216 CTX-M-217 is a CTX-M beta-lactamase. CTX-M-217 antibiotic_resistance ARO:3005640 CTX-M-217 ARO:3005640 CTX-M-217 CTX-M-218 is a CTX-M beta-lactamase. CTX-M-218 antibiotic_resistance ARO:3005641 CTX-M-218 ARO:3005641 CTX-M-218 CTX-M-219 is a CTX-M beta-lactamase. CTX-M-219 antibiotic_resistance ARO:3005642 CTX-M-219 ARO:3005642 CTX-M-219 CTX-M-220 is a CTX-M beta-lactamase. CTX-M-220 antibiotic_resistance ARO:3005643 CTX-M-220 ARO:3005643 CTX-M-220 CTX-M-221 is a CTX-M beta-lactamase. CTX-M-221 antibiotic_resistance ARO:3005644 CTX-M-221 ARO:3005644 CTX-M-221 CTX-M-222 is a CTX-M beta-lactamase. CTX-M-222 antibiotic_resistance ARO:3005645 CTX-M-222 ARO:3005645 CTX-M-222 CTX-M-223 is a CTX-M beta-lactamase. CTX-M-223 antibiotic_resistance ARO:3005646 CTX-M-223 ARO:3005646 CTX-M-223 CTX-M-224 is a CTX-M beta-lactamase. CTX-M-224 antibiotic_resistance ARO:3005647 CTX-M-224 ARO:3005647 CTX-M-224 CTX-M-225 is a CTX-M beta-lactamase. CTX-M-225 antibiotic_resistance ARO:3005648 CTX-M-225 ARO:3005648 CTX-M-225 CTX-M-226 is a CTX-M beta-lactamase. CTX-M-226 antibiotic_resistance ARO:3005649 CTX-M-226 ARO:3005649 CTX-M-226 CTX-M-227 is a CTX-M beta-lactamase. CTX-M-227 antibiotic_resistance ARO:3005650 CTX-M-227 ARO:3005650 CTX-M-227 CTX-M-228 is a CTX-M beta-lactamase. CTX-M-228 antibiotic_resistance ARO:3005651 CTX-M-228 ARO:3005651 CTX-M-228 CTX-M-229 is a CTX-M beta-lactamase. CTX-M-229 antibiotic_resistance ARO:3005652 CTX-M-229 ARO:3005652 CTX-M-229 CTX-M-230 is a CTX-M beta-lactamase. CTX-M-230 antibiotic_resistance ARO:3005653 CTX-M-230 ARO:3005653 CTX-M-230 CTX-M-231 is a CTX-M beta-lactamase. CTX-M-231 antibiotic_resistance ARO:3005654 CTX-M-231 ARO:3005654 CTX-M-231 CTX-M-232 is a CTX-M beta-lactamase. CTX-M-232 antibiotic_resistance ARO:3005655 CTX-M-232 ARO:3005655 CTX-M-232 CTX-M-233 is a CTX-M beta-lactamase. CTX-M-233 antibiotic_resistance ARO:3005656 CTX-M-233 ARO:3005656 CTX-M-233 CTX-M-234 is a CTX-M beta-lactamase. CTX-M-234 antibiotic_resistance ARO:3005657 CTX-M-234 ARO:3005657 CTX-M-234 CTX-M-235 is a CTX-M beta-lactamase. CTX-M-235 antibiotic_resistance ARO:3005658 CTX-M-235 ARO:3005658 CTX-M-235 CTX-M-236 is a CTX-M beta-lactamase. CTX-M-236 antibiotic_resistance ARO:3005659 CTX-M-236 ARO:3005659 CTX-M-236 CTX-M-237 is a CTX-M beta-lactamase. CTX-M-237 antibiotic_resistance ARO:3005660 CTX-M-237 ARO:3005660 CTX-M-237 CTX-M-238 is a CTX-M beta-lactamase. CTX-M-238 antibiotic_resistance ARO:3005661 CTX-M-238 ARO:3005661 CTX-M-238 CTX-M-239 is a CTX-M beta-lactamase. CTX-M-239 antibiotic_resistance ARO:3005662 CTX-M-239 ARO:3005662 CTX-M-239 CTX-M-240 is a CTX-M beta-lactamase. CTX-M-240 antibiotic_resistance ARO:3005663 CTX-M-240 ARO:3005663 CTX-M-240 CTX-M-241 is a CTX-M beta-lactamase. CTX-M-241 antibiotic_resistance ARO:3005664 CTX-M-241 ARO:3005664 CTX-M-241 CTX-M-242 is a CTX-M beta-lactamase. CTX-M-242 antibiotic_resistance ARO:3005665 CTX-M-242 ARO:3005665 CTX-M-242 CTX-M-244 is a CTX-M beta-lactamase. CTX-M-244 antibiotic_resistance ARO:3005666 CTX-M-244 ARO:3005666 CTX-M-244 CTX-M-97 is a CTX-M beta-lactamase. CTX-M-97 antibiotic_resistance ARO:3005667 CTX-M-97 ARO:3005667 CTX-M-97 GOB-19 is a GOB beta-lactamase. GOB-19 antibiotic_resistance ARO:3005668 GOB-19 ARO:3005668 GOB-19 GOB-20 is a GOB beta-lactamase. GOB-20 antibiotic_resistance ARO:3005669 GOB-20 ARO:3005669 GOB-20 GOB-21 is a GOB beta-lactamase. GOB-21 antibiotic_resistance ARO:3005670 GOB-21 ARO:3005670 GOB-21 GOB-22 is a GOB beta-lactamase. GOB-22 antibiotic_resistance ARO:3005671 GOB-22 ARO:3005671 GOB-22 GOB-23 is a GOB beta-lactamase. GOB-23 antibiotic_resistance ARO:3005672 GOB-23 ARO:3005672 GOB-23 GOB-24 is a GOB beta-lactamase. GOB-24 antibiotic_resistance ARO:3005673 GOB-24 ARO:3005673 GOB-24 GOB-25 is a GOB beta-lactamase. GOB-25 antibiotic_resistance ARO:3005674 GOB-25 ARO:3005674 GOB-25 GOB-26 is a GOB beta-lactamase. GOB-26 antibiotic_resistance ARO:3005675 GOB-26 ARO:3005675 GOB-26 GOB-27 is a GOB beta-lactamase. GOB-27 antibiotic_resistance ARO:3005676 GOB-27 ARO:3005676 GOB-27 GOB-28 is a GOB beta-lactamase. GOB-28 antibiotic_resistance ARO:3005677 GOB-28 ARO:3005677 GOB-28 GOB-29 is a GOB beta-lactamase. GOB-29 antibiotic_resistance ARO:3005678 GOB-29 ARO:3005678 GOB-29 GOB-30 is a GOB beta-lactamase. GOB-30 antibiotic_resistance ARO:3005679 GOB-30 ARO:3005679 GOB-30 GOB-31 is a GOB beta-lactamase. GOB-31 antibiotic_resistance ARO:3005680 GOB-31 ARO:3005680 GOB-31 GOB-32 is a GOB beta-lactamase. GOB-32 antibiotic_resistance ARO:3005681 GOB-32 ARO:3005681 GOB-32 GOB-33 is a GOB beta-lactamase. GOB-33 antibiotic_resistance ARO:3005682 GOB-33 ARO:3005682 GOB-33 GOB-34 is a GOB beta-lactamase. GOB-34 antibiotic_resistance ARO:3005683 GOB-34 ARO:3005683 GOB-34 GOB-35 is a GOB beta-lactamase. GOB-35 antibiotic_resistance ARO:3005684 GOB-35 ARO:3005684 GOB-35 GOB-36 is a GOB beta-lactamase. GOB-36 antibiotic_resistance ARO:3005685 GOB-36 ARO:3005685 GOB-36 GOB-37 is a GOB beta-lactamase. GOB-37 antibiotic_resistance ARO:3005686 GOB-37 ARO:3005686 GOB-37 GOB-38 is a GOB beta-lactamase. GOB-38 antibiotic_resistance ARO:3005687 GOB-38 ARO:3005687 GOB-38 GOB-39 is a GOB beta-lactamase. GOB-39 antibiotic_resistance ARO:3005688 GOB-39 ARO:3005688 GOB-39 GOB-40 is a GOB beta-lactamase. GOB-40 antibiotic_resistance ARO:3005689 GOB-40 ARO:3005689 GOB-40 GOB-41 is a GOB beta-lactamase. GOB-41 antibiotic_resistance ARO:3005690 GOB-41 ARO:3005690 GOB-41 GOB-42 is a GOB beta-lactamase. GOB-42 antibiotic_resistance ARO:3005691 GOB-42 ARO:3005691 GOB-42 GOB-43 is a GOB beta-lactamase. GOB-43 antibiotic_resistance ARO:3005692 GOB-43 ARO:3005692 GOB-43 GOB-44 is a GOB beta-lactamase. GOB-44 antibiotic_resistance ARO:3005693 GOB-44 ARO:3005693 GOB-44 GOB-45 is a GOB beta-lactamase. GOB-45 antibiotic_resistance ARO:3005694 GOB-45 ARO:3005694 GOB-45 GOB-46 is a GOB beta-lactamase. GOB-46 antibiotic_resistance ARO:3005695 GOB-46 ARO:3005695 GOB-46 GOB-48 is a GOB beta-lactamase. GOB-48 antibiotic_resistance ARO:3005696 GOB-48 ARO:3005696 GOB-48 GOB-49 is a GOB beta-lactamase. GOB-49 antibiotic_resistance ARO:3005697 GOB-49 ARO:3005697 GOB-49 GOB-50 is a GOB beta-lactamase. GOB-50 antibiotic_resistance ARO:3005698 GOB-50 ARO:3005698 GOB-50 GOB-51 is a GOB beta-lactamase. GOB-51 antibiotic_resistance ARO:3005699 GOB-51 ARO:3005699 GOB-51 NDM-30 is a NDM beta-lactamase. NDM-30 antibiotic_resistance ARO:3005700 NDM-30 ARO:3005700 NDM-30 NDM-31 is a NDM beta-lactamase. NDM-31 antibiotic_resistance ARO:3005701 NDM-31 ARO:3005701 NDM-31 OXA-114b is a OXA beta-lactamase. OXA-114b antibiotic_resistance ARO:3005702 OXA-114b ARO:3005702 OXA-114b OXA-114c is a OXA beta-lactamase. OXA-114c antibiotic_resistance ARO:3005703 OXA-114c ARO:3005703 OXA-114c OXA-114d is a OXA beta-lactamase. OXA-114d antibiotic_resistance ARO:3005704 OXA-114d ARO:3005704 OXA-114d OXA-114e is a OXA beta-lactamase. OXA-114e antibiotic_resistance ARO:3005705 OXA-114e ARO:3005705 OXA-114e OXA-114f is a OXA beta-lactamase. OXA-114f antibiotic_resistance ARO:3005706 OXA-114f ARO:3005706 OXA-114f OXA-114g is a OXA beta-lactamase. OXA-114g antibiotic_resistance ARO:3005707 OXA-114g ARO:3005707 OXA-114g OXA-114h is a OXA beta-lactamase. OXA-114h antibiotic_resistance ARO:3005708 OXA-114h ARO:3005708 OXA-114h OXA-114i is a OXA beta-lactamase. OXA-114i antibiotic_resistance ARO:3005709 OXA-114i ARO:3005709 OXA-114i OXA-114j is a OXA beta-lactamase. OXA-114j antibiotic_resistance ARO:3005710 OXA-114j ARO:3005710 OXA-114j OXA-114k is a OXA beta-lactamase. OXA-114k antibiotic_resistance ARO:3005711 OXA-114k ARO:3005711 OXA-114k OXA-114l is a OXA beta-lactamase. OXA-114l antibiotic_resistance ARO:3005712 OXA-114l ARO:3005712 OXA-114l OXA-114m is a OXA beta-lactamase. OXA-114m antibiotic_resistance ARO:3005713 OXA-114m ARO:3005713 OXA-114m OXA-114n is a OXA beta-lactamase. OXA-114n antibiotic_resistance ARO:3005714 OXA-114n ARO:3005714 OXA-114n OXA-114p is a OXA beta-lactamase. OXA-114p antibiotic_resistance ARO:3005715 OXA-114p ARO:3005715 OXA-114p OXA-114q is a OXA beta-lactamase. OXA-114q antibiotic_resistance ARO:3005716 OXA-114q ARO:3005716 OXA-114q OXA-114r is a OXA beta-lactamase. OXA-114r antibiotic_resistance ARO:3005717 OXA-114r ARO:3005717 OXA-114r OXA-114s is a OXA beta-lactamase. OXA-114s antibiotic_resistance ARO:3005718 OXA-114s ARO:3005718 OXA-114s OXA-114t is a OXA beta-lactamase. OXA-114t antibiotic_resistance ARO:3005719 OXA-114t ARO:3005719 OXA-114t OXA-114u is a OXA beta-lactamase. OXA-114u antibiotic_resistance ARO:3005720 OXA-114u ARO:3005720 OXA-114u OXA-114v is a OXA beta-lactamase. OXA-114v antibiotic_resistance ARO:3005721 OXA-114v ARO:3005721 OXA-114v OXA-114w is a OXA beta-lactamase. OXA-114w antibiotic_resistance ARO:3005722 OXA-114w ARO:3005722 OXA-114w OXA-114x is a OXA beta-lactamase. OXA-114x antibiotic_resistance ARO:3005723 OXA-114x ARO:3005723 OXA-114x OXA-489 is a OXA beta-lactamase. OXA-489 antibiotic_resistance ARO:3005724 OXA-489 ARO:3005724 OXA-489 OXA-491 is a OXA beta-lactamase. OXA-491 antibiotic_resistance ARO:3005725 OXA-491 ARO:3005725 OXA-491 OXA-493 is a OXA beta-lactamase. OXA-493 antibiotic_resistance ARO:3005726 OXA-493 ARO:3005726 OXA-493 OXA-494 is a OXA beta-lactamase. OXA-494 antibiotic_resistance ARO:3005727 OXA-494 ARO:3005727 OXA-494 OXA-497 is a OXA beta-lactamase. OXA-497 antibiotic_resistance ARO:3005728 OXA-497 ARO:3005728 OXA-497 OXA-498 is a OXA beta-lactamase. OXA-498 antibiotic_resistance ARO:3005729 OXA-498 ARO:3005729 OXA-498 OXA-500 is a OXA beta-lactamase. OXA-500 antibiotic_resistance ARO:3005730 OXA-500 ARO:3005730 OXA-500 OXA-501 is a OXA beta-lactamase. OXA-501 antibiotic_resistance ARO:3005731 OXA-501 ARO:3005731 OXA-501 OXA-502 is a OXA beta-lactamase. OXA-502 antibiotic_resistance ARO:3005732 OXA-502 ARO:3005732 OXA-502 OXA-503 is a OXA beta-lactamase. OXA-503 antibiotic_resistance ARO:3005733 OXA-503 ARO:3005733 OXA-503 OXA-504 is a OXA beta-lactamase. OXA-504 antibiotic_resistance ARO:3005734 OXA-504 ARO:3005734 OXA-504 OXA-505 is a OXA beta-lactamase. OXA-505 antibiotic_resistance ARO:3005735 OXA-505 ARO:3005735 OXA-505 OXA-506 is a OXA beta-lactamase. OXA-506 antibiotic_resistance ARO:3005736 OXA-506 ARO:3005736 OXA-506 OXA-507 is a OXA beta-lactamase. OXA-507 antibiotic_resistance ARO:3005737 OXA-507 ARO:3005737 OXA-507 OXA-508 is a OXA beta-lactamase. OXA-508 antibiotic_resistance ARO:3005738 OXA-508 ARO:3005738 OXA-508 OXA-509 is a OXA beta-lactamase. OXA-509 antibiotic_resistance ARO:3005739 OXA-509 ARO:3005739 OXA-509 OXA-510 is a OXA beta-lactamase. OXA-510 antibiotic_resistance ARO:3005740 OXA-510 ARO:3005740 OXA-510 OXA-511 is a OXA beta-lactamase. OXA-511 antibiotic_resistance ARO:3005741 OXA-511 ARO:3005741 OXA-511 OXA-512 is a OXA beta-lactamase. OXA-512 antibiotic_resistance ARO:3005742 OXA-512 ARO:3005742 OXA-512 OXA-513 is a OXA beta-lactamase. OXA-513 antibiotic_resistance ARO:3005743 OXA-513 ARO:3005743 OXA-513 OXA-514 is a OXA beta-lactamase. OXA-514 antibiotic_resistance ARO:3005744 OXA-514 ARO:3005744 OXA-514 OXA-515 is a OXA beta-lactamase. OXA-515 antibiotic_resistance ARO:3005745 OXA-515 ARO:3005745 OXA-515 OXA-516 is a OXA beta-lactamase. OXA-516 antibiotic_resistance ARO:3005746 OXA-516 ARO:3005746 OXA-516 OXA-517 is a OXA beta-lactamase. OXA-517 antibiotic_resistance ARO:3005747 OXA-517 ARO:3005747 OXA-517 OXA-518 is a OXA beta-lactamase. OXA-518 antibiotic_resistance ARO:3005748 OXA-518 ARO:3005748 OXA-518 OXA-519 is a OXA beta-lactamase. OXA-519 antibiotic_resistance ARO:3005749 OXA-519 ARO:3005749 OXA-519 OXA-520 is a OXA beta-lactamase. OXA-520 antibiotic_resistance ARO:3005750 OXA-520 ARO:3005750 OXA-520 OXA-521 is a OXA beta-lactamase. OXA-521 antibiotic_resistance ARO:3005751 OXA-521 ARO:3005751 OXA-521 OXA-522 is a OXA beta-lactamase. OXA-522 antibiotic_resistance ARO:3005752 OXA-522 ARO:3005752 OXA-522 OXA-523 is a OXA beta-lactamase. OXA-523 antibiotic_resistance ARO:3005753 OXA-523 ARO:3005753 OXA-523 OXA-524 is a OXA beta-lactamase. OXA-524 antibiotic_resistance ARO:3005754 OXA-524 ARO:3005754 OXA-524 OXA-525 is a OXA beta-lactamase. OXA-525 antibiotic_resistance ARO:3005755 OXA-525 ARO:3005755 OXA-525 OXA-526 is a OXA beta-lactamase. OXA-526 antibiotic_resistance ARO:3005756 OXA-526 ARO:3005756 OXA-526 OXA-527 is a OXA beta-lactamase. OXA-527 antibiotic_resistance ARO:3005757 OXA-527 ARO:3005757 OXA-527 OXA-528 is a OXA beta-lactamase. OXA-528 antibiotic_resistance ARO:3005758 OXA-528 ARO:3005758 OXA-528 OXA-529 is a OXA beta-lactamase. OXA-529 antibiotic_resistance ARO:3005759 OXA-529 ARO:3005759 OXA-529 OXA-530 is a OXA beta-lactamase. OXA-530 antibiotic_resistance ARO:3005760 OXA-530 ARO:3005760 OXA-530 OXA-531 is a OXA beta-lactamase. OXA-531 antibiotic_resistance ARO:3005761 OXA-531 ARO:3005761 OXA-531 OXA-532 is a OXA beta-lactamase. OXA-532 antibiotic_resistance ARO:3005762 OXA-532 ARO:3005762 OXA-532 OXA-533 is a OXA beta-lactamase. OXA-533 antibiotic_resistance ARO:3005763 OXA-533 ARO:3005763 OXA-533 OXA-534 is a OXA beta-lactamase. OXA-534 antibiotic_resistance ARO:3005764 OXA-534 ARO:3005764 OXA-534 OXA-536 is a OXA beta-lactamase. OXA-536 antibiotic_resistance ARO:3005765 OXA-536 ARO:3005765 OXA-536 OXA-537 is a OXA beta-lactamase. OXA-537 antibiotic_resistance ARO:3005766 OXA-537 ARO:3005766 OXA-537 OXA-538 is a OXA beta-lactamase. OXA-538 antibiotic_resistance ARO:3005767 OXA-538 ARO:3005767 OXA-538 OXA-542 is a OXA beta-lactamase. OXA-542 antibiotic_resistance ARO:3005768 OXA-542 ARO:3005768 OXA-542 OXA-545 is a OXA beta-lactamase. OXA-545 antibiotic_resistance ARO:3005769 OXA-545 ARO:3005769 OXA-545 OXA-546 is a OXA beta-lactamase. OXA-546 antibiotic_resistance ARO:3005770 OXA-546 ARO:3005770 OXA-546 OXA-547 is a OXA beta-lactamase. OXA-547 antibiotic_resistance ARO:3005771 OXA-547 ARO:3005771 OXA-547 OXA-548 is a OXA beta-lactamase. OXA-548 antibiotic_resistance ARO:3005772 OXA-548 ARO:3005772 OXA-548 OXA-549 is a OXA beta-lactamase. OXA-549 antibiotic_resistance ARO:3005773 OXA-549 ARO:3005773 OXA-549 OXA-550 is a OXA beta-lactamase. OXA-550 antibiotic_resistance ARO:3005774 OXA-550 ARO:3005774 OXA-550 OXA-551 is a OXA beta-lactamase. OXA-551 antibiotic_resistance ARO:3005775 OXA-551 ARO:3005775 OXA-551 OXA-552 is a OXA beta-lactamase. OXA-552 antibiotic_resistance ARO:3005776 OXA-552 ARO:3005776 OXA-552 OXA-553 is a OXA beta-lactamase. OXA-553 antibiotic_resistance ARO:3005777 OXA-553 ARO:3005777 OXA-553 OXA-554 is a OXA beta-lactamase. OXA-554 antibiotic_resistance ARO:3005778 OXA-554 ARO:3005778 OXA-554 OXA-555 is a OXA beta-lactamase. OXA-555 antibiotic_resistance ARO:3005779 OXA-555 ARO:3005779 OXA-555 OXA-556 is a OXA beta-lactamase. OXA-556 antibiotic_resistance ARO:3005780 OXA-556 ARO:3005780 OXA-556 OXA-557 is a OXA beta-lactamase. OXA-557 antibiotic_resistance ARO:3005781 OXA-557 ARO:3005781 OXA-557 OXA-558 is a OXA beta-lactamase. OXA-558 antibiotic_resistance ARO:3005782 OXA-558 ARO:3005782 OXA-558 OXA-559 is a OXA beta-lactamase. OXA-559 antibiotic_resistance ARO:3005783 OXA-559 ARO:3005783 OXA-559 OXA-560 is a OXA beta-lactamase. OXA-560 antibiotic_resistance ARO:3005784 OXA-560 ARO:3005784 OXA-560 OXA-561 is a OXA beta-lactamase. OXA-561 antibiotic_resistance ARO:3005785 OXA-561 ARO:3005785 OXA-561 OXA-562 is a OXA beta-lactamase. OXA-562 antibiotic_resistance ARO:3005786 OXA-562 ARO:3005786 OXA-562 OXA-563 is a OXA beta-lactamase. OXA-563 antibiotic_resistance ARO:3005787 OXA-563 ARO:3005787 OXA-563 OXA-564 is a OXA beta-lactamase. OXA-564 antibiotic_resistance ARO:3005788 OXA-564 ARO:3005788 OXA-564 OXA-565 is a OXA beta-lactamase. OXA-565 antibiotic_resistance ARO:3005789 OXA-565 ARO:3005789 OXA-565 OXA-566 is a OXA beta-lactamase. OXA-566 antibiotic_resistance ARO:3005790 OXA-566 ARO:3005790 OXA-566 OXA-567 is a OXA beta-lactamase. OXA-567 antibiotic_resistance ARO:3005791 OXA-567 ARO:3005791 OXA-567 OXA-568 is a OXA beta-lactamase. OXA-568 antibiotic_resistance ARO:3005792 OXA-568 ARO:3005792 OXA-568 OXA-569 is a OXA beta-lactamase. OXA-569 antibiotic_resistance ARO:3005793 OXA-569 ARO:3005793 OXA-569 OXA-572 is a OXA beta-lactamase. OXA-572 antibiotic_resistance ARO:3005794 OXA-572 ARO:3005794 OXA-572 OXA-574 is a OXA beta-lactamase. OXA-574 antibiotic_resistance ARO:3005795 OXA-574 ARO:3005795 OXA-574 OXA-575 is a OXA beta-lactamase. OXA-575 antibiotic_resistance ARO:3005796 OXA-575 ARO:3005796 OXA-575 OXA-576 is a OXA beta-lactamase. OXA-576 antibiotic_resistance ARO:3005797 OXA-576 ARO:3005797 OXA-576 OXA-577 is a OXA beta-lactamase. OXA-577 antibiotic_resistance ARO:3005798 OXA-577 ARO:3005798 OXA-577 OXA-578 is a OXA beta-lactamase. OXA-578 antibiotic_resistance ARO:3005799 OXA-578 ARO:3005799 OXA-578 OXA-579 is a OXA beta-lactamase. OXA-579 antibiotic_resistance ARO:3005800 OXA-579 ARO:3005800 OXA-579 OXA-580 is a OXA beta-lactamase. OXA-580 antibiotic_resistance ARO:3005801 OXA-580 ARO:3005801 OXA-580 OXA-581 is a OXA beta-lactamase. OXA-581 antibiotic_resistance ARO:3005802 OXA-581 ARO:3005802 OXA-581 OXA-582 is a OXA beta-lactamase. OXA-582 antibiotic_resistance ARO:3005803 OXA-582 ARO:3005803 OXA-582 OXA-583 is a OXA beta-lactamase. OXA-583 antibiotic_resistance ARO:3005804 OXA-583 ARO:3005804 OXA-583 OXA-584 is a OXA beta-lactamase. OXA-584 antibiotic_resistance ARO:3005805 OXA-584 ARO:3005805 OXA-584 OXA-585 is a OXA beta-lactamase. OXA-585 antibiotic_resistance ARO:3005806 OXA-585 ARO:3005806 OXA-585 OXA-586 is a OXA beta-lactamase. OXA-586 antibiotic_resistance ARO:3005807 OXA-586 ARO:3005807 OXA-586 OXA-587 is a OXA beta-lactamase. OXA-587 antibiotic_resistance ARO:3005808 OXA-587 ARO:3005808 OXA-587 OXA-588 is a OXA beta-lactamase. OXA-588 antibiotic_resistance ARO:3005809 OXA-588 ARO:3005809 OXA-588 OXA-589 is a OXA beta-lactamase. OXA-589 antibiotic_resistance ARO:3005810 OXA-589 ARO:3005810 OXA-589 OXA-590 is a OXA beta-lactamase. OXA-590 antibiotic_resistance ARO:3005811 OXA-590 ARO:3005811 OXA-590 OXA-591 is a OXA beta-lactamase. OXA-591 antibiotic_resistance ARO:3005812 OXA-591 ARO:3005812 OXA-591 OXA-592 is a OXA beta-lactamase. OXA-592 antibiotic_resistance ARO:3005813 OXA-592 ARO:3005813 OXA-592 OXA-593 is a OXA beta-lactamase. OXA-593 antibiotic_resistance ARO:3005814 OXA-593 ARO:3005814 OXA-593 OXA-594 is a OXA beta-lactamase. OXA-594 antibiotic_resistance ARO:3005815 OXA-594 ARO:3005815 OXA-594 OXA-595 is a OXA beta-lactamase. OXA-595 antibiotic_resistance ARO:3005816 OXA-595 ARO:3005816 OXA-595 OXA-596 is a OXA beta-lactamase. OXA-596 antibiotic_resistance ARO:3005817 OXA-596 ARO:3005817 OXA-596 OXA-597 is a OXA beta-lactamase. OXA-597 antibiotic_resistance ARO:3005818 OXA-597 ARO:3005818 OXA-597 OXA-598 is a OXA beta-lactamase. OXA-598 antibiotic_resistance ARO:3005819 OXA-598 ARO:3005819 OXA-598 OXA-599 is a OXA beta-lactamase. OXA-599 antibiotic_resistance ARO:3005820 OXA-599 ARO:3005820 OXA-599 OXA-600 is a OXA beta-lactamase. OXA-600 antibiotic_resistance ARO:3005821 OXA-600 ARO:3005821 OXA-600 OXA-601 is a OXA beta-lactamase. OXA-601 antibiotic_resistance ARO:3005822 OXA-601 ARO:3005822 OXA-601 OXA-602 is a OXA beta-lactamase. OXA-602 antibiotic_resistance ARO:3005823 OXA-602 ARO:3005823 OXA-602 OXA-603 is a OXA beta-lactamase. OXA-603 antibiotic_resistance ARO:3005824 OXA-603 ARO:3005824 OXA-603 OXA-604 is a OXA beta-lactamase. OXA-604 antibiotic_resistance ARO:3005825 OXA-604 ARO:3005825 OXA-604 OXA-605 is a OXA beta-lactamase. OXA-605 antibiotic_resistance ARO:3005826 OXA-605 ARO:3005826 OXA-605 OXA-606 is a OXA beta-lactamase. OXA-606 antibiotic_resistance ARO:3005827 OXA-606 ARO:3005827 OXA-606 OXA-607 is a OXA beta-lactamase. OXA-607 antibiotic_resistance ARO:3005828 OXA-607 ARO:3005828 OXA-607 OXA-608 is a OXA beta-lactamase. OXA-608 antibiotic_resistance ARO:3005829 OXA-608 ARO:3005829 OXA-608 OXA-609 is a OXA beta-lactamase. OXA-609 antibiotic_resistance ARO:3005830 OXA-609 ARO:3005830 OXA-609 OXA-610 is a OXA beta-lactamase. OXA-610 antibiotic_resistance ARO:3005831 OXA-610 ARO:3005831 OXA-610 OXA-611 is a OXA beta-lactamase. OXA-611 antibiotic_resistance ARO:3005832 OXA-611 ARO:3005832 OXA-611 OXA-612 is a OXA beta-lactamase. OXA-612 antibiotic_resistance ARO:3005833 OXA-612 ARO:3005833 OXA-612 OXA-613 is a OXA beta-lactamase. OXA-613 antibiotic_resistance ARO:3005834 OXA-613 ARO:3005834 OXA-613 OXA-614 is a OXA beta-lactamase. OXA-614 antibiotic_resistance ARO:3005835 OXA-614 ARO:3005835 OXA-614 OXA-615 is a OXA beta-lactamase. OXA-615 antibiotic_resistance ARO:3005836 OXA-615 ARO:3005836 OXA-615 OXA-616 is a OXA beta-lactamase. OXA-616 antibiotic_resistance ARO:3005837 OXA-616 ARO:3005837 OXA-616 OXA-617 is a OXA beta-lactamase. OXA-617 antibiotic_resistance ARO:3005838 OXA-617 ARO:3005838 OXA-617 OXA-618 is a OXA beta-lactamase. OXA-618 antibiotic_resistance ARO:3005839 OXA-618 ARO:3005839 OXA-618 OXA-619 is a OXA beta-lactamase. OXA-619 antibiotic_resistance ARO:3005840 OXA-619 ARO:3005840 OXA-619 OXA-620 is a OXA beta-lactamase. OXA-620 antibiotic_resistance ARO:3005841 OXA-620 ARO:3005841 OXA-620 OXA-621 is a OXA beta-lactamase. OXA-621 antibiotic_resistance ARO:3005842 OXA-621 ARO:3005842 OXA-621 OXA-622 is a OXA beta-lactamase. OXA-622 antibiotic_resistance ARO:3005843 OXA-622 ARO:3005843 OXA-622 OXA-623 is a OXA beta-lactamase. OXA-623 antibiotic_resistance ARO:3005844 OXA-623 ARO:3005844 OXA-623 OXA-624 is a OXA beta-lactamase. OXA-624 antibiotic_resistance ARO:3005845 OXA-624 ARO:3005845 OXA-624 OXA-625 is a OXA beta-lactamase. OXA-625 antibiotic_resistance ARO:3005846 OXA-625 ARO:3005846 OXA-625 OXA-626 is a OXA beta-lactamase. OXA-626 antibiotic_resistance ARO:3005847 OXA-626 ARO:3005847 OXA-626 OXA-627 is a OXA beta-lactamase. OXA-627 antibiotic_resistance ARO:3005848 OXA-627 ARO:3005848 OXA-627 OXA-628 is a OXA beta-lactamase. OXA-628 antibiotic_resistance ARO:3005849 OXA-628 ARO:3005849 OXA-628 OXA-629 is a OXA beta-lactamase. OXA-629 antibiotic_resistance ARO:3005850 OXA-629 ARO:3005850 OXA-629 OXA-630 is a OXA beta-lactamase. OXA-630 antibiotic_resistance ARO:3005851 OXA-630 ARO:3005851 OXA-630 OXA-631 is a OXA beta-lactamase. OXA-631 antibiotic_resistance ARO:3005852 OXA-631 ARO:3005852 OXA-631 OXA-632 is a OXA beta-lactamase. OXA-632 antibiotic_resistance ARO:3005853 OXA-632 ARO:3005853 OXA-632 OXA-633 is a OXA beta-lactamase. OXA-633 antibiotic_resistance ARO:3005854 OXA-633 ARO:3005854 OXA-633 OXA-634 is a OXA beta-lactamase. OXA-634 antibiotic_resistance ARO:3005855 OXA-634 ARO:3005855 OXA-634 OXA-635 is a OXA beta-lactamase. OXA-635 antibiotic_resistance ARO:3005856 OXA-635 ARO:3005856 OXA-635 OXA-636 is a OXA beta-lactamase. OXA-636 antibiotic_resistance ARO:3005857 OXA-636 ARO:3005857 OXA-636 OXA-637 is a OXA beta-lactamase. OXA-637 antibiotic_resistance ARO:3005858 OXA-637 ARO:3005858 OXA-637 OXA-638 is a OXA beta-lactamase. OXA-638 antibiotic_resistance ARO:3005859 OXA-638 ARO:3005859 OXA-638 OXA-639 is a OXA beta-lactamase. OXA-639 antibiotic_resistance ARO:3005860 OXA-639 ARO:3005860 OXA-639 OXA-640 is a OXA beta-lactamase. OXA-640 antibiotic_resistance ARO:3005861 OXA-640 ARO:3005861 OXA-640 OXA-642 is a OXA beta-lactamase. OXA-642 antibiotic_resistance ARO:3005862 OXA-642 ARO:3005862 OXA-642 OXA-643 is a OXA beta-lactamase. OXA-643 antibiotic_resistance ARO:3005863 OXA-643 ARO:3005863 OXA-643 OXA-644 is a OXA beta-lactamase. OXA-644 antibiotic_resistance ARO:3005864 OXA-644 ARO:3005864 OXA-644 OXA-645 is a OXA beta-lactamase. OXA-645 antibiotic_resistance ARO:3005865 OXA-645 ARO:3005865 OXA-645 OXA-650 is a OXA beta-lactamase. OXA-650 antibiotic_resistance ARO:3005866 OXA-650 ARO:3005866 OXA-650 OXA-651 is a OXA beta-lactamase. OXA-651 antibiotic_resistance ARO:3005867 OXA-651 ARO:3005867 OXA-651 OXA-652 is a OXA beta-lactamase. OXA-652 antibiotic_resistance ARO:3005868 OXA-652 ARO:3005868 OXA-652 OXA-654 is a OXA beta-lactamase. OXA-654 antibiotic_resistance ARO:3005869 OXA-654 ARO:3005869 OXA-654 OXA-655 is a OXA beta-lactamase. OXA-655 antibiotic_resistance ARO:3005870 OXA-655 ARO:3005870 OXA-655 OXA-656 is a OXA beta-lactamase. OXA-656 antibiotic_resistance ARO:3005871 OXA-656 ARO:3005871 OXA-656 OXA-657 is a OXA beta-lactamase. OXA-657 antibiotic_resistance ARO:3005872 OXA-657 ARO:3005872 OXA-657 OXA-658 is a OXA beta-lactamase. OXA-658 antibiotic_resistance ARO:3005873 OXA-658 ARO:3005873 OXA-658 OXA-659 is a OXA beta-lactamase. OXA-659 antibiotic_resistance ARO:3005874 OXA-659 ARO:3005874 OXA-659 OXA-660 is a OXA beta-lactamase. OXA-660 antibiotic_resistance ARO:3005875 OXA-660 ARO:3005875 OXA-660 OXA-661 is a OXA beta-lactamase. OXA-661 antibiotic_resistance ARO:3005876 OXA-661 ARO:3005876 OXA-661 OXA-662 is a OXA beta-lactamase. OXA-662 antibiotic_resistance ARO:3005877 OXA-662 ARO:3005877 OXA-662 OXA-666 is a OXA beta-lactamase. OXA-666 antibiotic_resistance ARO:3005878 OXA-666 ARO:3005878 OXA-666 OXA-667 is a OXA beta-lactamase. OXA-667 antibiotic_resistance ARO:3005879 OXA-667 ARO:3005879 OXA-667 OXA-669 is a OXA beta-lactamase. OXA-669 antibiotic_resistance ARO:3005880 OXA-669 ARO:3005880 OXA-669 OXA-670 is a OXA beta-lactamase. OXA-670 antibiotic_resistance ARO:3005881 OXA-670 ARO:3005881 OXA-670 OXA-674 is a OXA beta-lactamase. OXA-674 antibiotic_resistance ARO:3005882 OXA-674 ARO:3005882 OXA-674 OXA-675 is a OXA beta-lactamase. OXA-675 antibiotic_resistance ARO:3005883 OXA-675 ARO:3005883 OXA-675 OXA-676 is a OXA beta-lactamase. OXA-676 antibiotic_resistance ARO:3005884 OXA-676 ARO:3005884 OXA-676 OXA-677 is a OXA beta-lactamase. OXA-677 antibiotic_resistance ARO:3005885 OXA-677 ARO:3005885 OXA-677 OXA-678 is a OXA beta-lactamase. OXA-678 antibiotic_resistance ARO:3005886 OXA-678 ARO:3005886 OXA-678 OXA-679 is a OXA beta-lactamase. OXA-679 antibiotic_resistance ARO:3005887 OXA-679 ARO:3005887 OXA-679 OXA-680 is a OXA beta-lactamase. OXA-680 antibiotic_resistance ARO:3005888 OXA-680 ARO:3005888 OXA-680 OXA-682 is a OXA beta-lactamase. OXA-682 antibiotic_resistance ARO:3005889 OXA-682 ARO:3005889 OXA-682 OXA-683 is a OXA beta-lactamase. OXA-683 antibiotic_resistance ARO:3005890 OXA-683 ARO:3005890 OXA-683 OXA-684 is a OXA beta-lactamase. OXA-684 antibiotic_resistance ARO:3005891 OXA-684 ARO:3005891 OXA-684 OXA-685 is a OXA beta-lactamase. OXA-685 antibiotic_resistance ARO:3005892 OXA-685 ARO:3005892 OXA-685 OXA-686 is a OXA beta-lactamase. OXA-686 antibiotic_resistance ARO:3005893 OXA-686 ARO:3005893 OXA-686 OXA-687 is a OXA beta-lactamase. OXA-687 antibiotic_resistance ARO:3005894 OXA-687 ARO:3005894 OXA-687 OXA-688 is a OXA beta-lactamase. OXA-688 antibiotic_resistance ARO:3005895 OXA-688 ARO:3005895 OXA-688 OXA-689 is a OXA beta-lactamase. OXA-689 antibiotic_resistance ARO:3005896 OXA-689 ARO:3005896 OXA-689 OXA-690 is a OXA beta-lactamase. OXA-690 antibiotic_resistance ARO:3005897 OXA-690 ARO:3005897 OXA-690 OXA-691 is a OXA beta-lactamase. OXA-691 antibiotic_resistance ARO:3005898 OXA-691 ARO:3005898 OXA-691 OXA-692 is a OXA beta-lactamase. OXA-692 antibiotic_resistance ARO:3005899 OXA-692 ARO:3005899 OXA-692 OXA-693 is a OXA beta-lactamase. OXA-693 antibiotic_resistance ARO:3005900 OXA-693 ARO:3005900 OXA-693 OXA-694 is a OXA beta-lactamase. OXA-694 antibiotic_resistance ARO:3005901 OXA-694 ARO:3005901 OXA-694 OXA-695 is a OXA beta-lactamase. OXA-695 antibiotic_resistance ARO:3005902 OXA-695 ARO:3005902 OXA-695 OXA-696 is a OXA beta-lactamase. OXA-696 antibiotic_resistance ARO:3005903 OXA-696 ARO:3005903 OXA-696 OXA-697 is a OXA beta-lactamase. OXA-697 antibiotic_resistance ARO:3005904 OXA-697 ARO:3005904 OXA-697 OXA-698 is a OXA beta-lactamase. OXA-698 antibiotic_resistance ARO:3005905 OXA-698 ARO:3005905 OXA-698 OXA-699 is a OXA beta-lactamase. OXA-699 antibiotic_resistance ARO:3005906 OXA-699 ARO:3005906 OXA-699 OXA-700 is a OXA beta-lactamase. OXA-700 antibiotic_resistance ARO:3005907 OXA-700 ARO:3005907 OXA-700 OXA-701 is a OXA beta-lactamase. OXA-701 antibiotic_resistance ARO:3005908 OXA-701 ARO:3005908 OXA-701 OXA-702 is a OXA beta-lactamase. OXA-702 antibiotic_resistance ARO:3005909 OXA-702 ARO:3005909 OXA-702 OXA-703 is a OXA beta-lactamase. OXA-703 antibiotic_resistance ARO:3005910 OXA-703 ARO:3005910 OXA-703 OXA-704 is a OXA beta-lactamase. OXA-704 antibiotic_resistance ARO:3005911 OXA-704 ARO:3005911 OXA-704 OXA-705 is a OXA beta-lactamase. OXA-705 antibiotic_resistance ARO:3005912 OXA-705 ARO:3005912 OXA-705 OXA-706 is a OXA beta-lactamase. OXA-706 antibiotic_resistance ARO:3005913 OXA-706 ARO:3005913 OXA-706 OXA-707 is a OXA beta-lactamase. OXA-707 antibiotic_resistance ARO:3005914 OXA-707 ARO:3005914 OXA-707 OXA-708 is a OXA beta-lactamase. OXA-708 antibiotic_resistance ARO:3005915 OXA-708 ARO:3005915 OXA-708 OXA-709 is a OXA beta-lactamase. OXA-709 antibiotic_resistance ARO:3005916 OXA-709 ARO:3005916 OXA-709 OXA-710 is a OXA beta-lactamase. OXA-710 antibiotic_resistance ARO:3005917 OXA-710 ARO:3005917 OXA-710 OXA-711 is a OXA beta-lactamase. OXA-711 antibiotic_resistance ARO:3005918 OXA-711 ARO:3005918 OXA-711 OXA-712 is a OXA beta-lactamase. OXA-712 antibiotic_resistance ARO:3005919 OXA-712 ARO:3005919 OXA-712 OXA-713 is a OXA beta-lactamase. OXA-713 antibiotic_resistance ARO:3005920 OXA-713 ARO:3005920 OXA-713 OXA-714 is a OXA beta-lactamase. OXA-714 antibiotic_resistance ARO:3005921 OXA-714 ARO:3005921 OXA-714 OXA-715 is a OXA beta-lactamase. OXA-715 antibiotic_resistance ARO:3005922 OXA-715 ARO:3005922 OXA-715 OXA-716 is a OXA beta-lactamase. OXA-716 antibiotic_resistance ARO:3005923 OXA-716 ARO:3005923 OXA-716 OXA-717 is a OXA beta-lactamase. OXA-717 antibiotic_resistance ARO:3005924 OXA-717 ARO:3005924 OXA-717 OXA-718 is a OXA beta-lactamase. OXA-718 antibiotic_resistance ARO:3005925 OXA-718 ARO:3005925 OXA-718 OXA-719 is a OXA beta-lactamase. OXA-719 antibiotic_resistance ARO:3005926 OXA-719 ARO:3005926 OXA-719 OXA-720 is a OXA beta-lactamase. OXA-720 antibiotic_resistance ARO:3005927 OXA-720 ARO:3005927 OXA-720 OXA-721 is a OXA beta-lactamase. OXA-721 antibiotic_resistance ARO:3005928 OXA-721 ARO:3005928 OXA-721 OXA-722 is a OXA beta-lactamase. OXA-722 antibiotic_resistance ARO:3005929 OXA-722 ARO:3005929 OXA-722 OXA-723 is a OXA beta-lactamase. OXA-723 antibiotic_resistance ARO:3005930 OXA-723 ARO:3005930 OXA-723 OXA-726 is a OXA beta-lactamase. OXA-726 antibiotic_resistance ARO:3005931 OXA-726 ARO:3005931 OXA-726 OXA-727 is a OXA beta-lactamase. OXA-727 antibiotic_resistance ARO:3005932 OXA-727 ARO:3005932 OXA-727 OXA-728 is a OXA beta-lactamase. OXA-728 antibiotic_resistance ARO:3005933 OXA-728 ARO:3005933 OXA-728 OXA-729 is a OXA beta-lactamase. OXA-729 antibiotic_resistance ARO:3005934 OXA-729 ARO:3005934 OXA-729 OXA-730 is a OXA beta-lactamase. OXA-730 antibiotic_resistance ARO:3005935 OXA-730 ARO:3005935 OXA-730 OXA-731 is a OXA beta-lactamase. OXA-731 antibiotic_resistance ARO:3005936 OXA-731 ARO:3005936 OXA-731 OXA-732 is a OXA beta-lactamase. OXA-732 antibiotic_resistance ARO:3005937 OXA-732 ARO:3005937 OXA-732 OXA-733 is a OXA beta-lactamase. OXA-733 antibiotic_resistance ARO:3005938 OXA-733 ARO:3005938 OXA-733 OXA-734 is a OXA beta-lactamase. OXA-734 antibiotic_resistance ARO:3005939 OXA-734 ARO:3005939 OXA-734 OXA-735 is a OXA beta-lactamase. OXA-735 antibiotic_resistance ARO:3005940 OXA-735 ARO:3005940 OXA-735 OXA-736 is a OXA beta-lactamase. OXA-736 antibiotic_resistance ARO:3005941 OXA-736 ARO:3005941 OXA-736 OXA-738 is a OXA beta-lactamase. OXA-738 antibiotic_resistance ARO:3005942 OXA-738 ARO:3005942 OXA-738 OXA-739 is a OXA beta-lactamase. OXA-739 antibiotic_resistance ARO:3005943 OXA-739 ARO:3005943 OXA-739 OXA-740 is a OXA beta-lactamase. OXA-740 antibiotic_resistance ARO:3005944 OXA-740 ARO:3005944 OXA-740 OXA-741 is a OXA beta-lactamase. OXA-741 antibiotic_resistance ARO:3005945 OXA-741 ARO:3005945 OXA-741 OXA-742 is a OXA beta-lactamase. OXA-742 antibiotic_resistance ARO:3005946 OXA-742 ARO:3005946 OXA-742 OXA-743 is a OXA beta-lactamase. OXA-743 antibiotic_resistance ARO:3005947 OXA-743 ARO:3005947 OXA-743 OXA-744 is a OXA beta-lactamase. OXA-744 antibiotic_resistance ARO:3005948 OXA-744 ARO:3005948 OXA-744 OXA-745 is a OXA beta-lactamase. OXA-745 antibiotic_resistance ARO:3005949 OXA-745 ARO:3005949 OXA-745 OXA-746 is a OXA beta-lactamase. OXA-746 antibiotic_resistance ARO:3005950 OXA-746 ARO:3005950 OXA-746 OXA-747 is a OXA beta-lactamase. OXA-747 antibiotic_resistance ARO:3005951 OXA-747 ARO:3005951 OXA-747 OXA-748 is a OXA beta-lactamase. OXA-748 antibiotic_resistance ARO:3005952 OXA-748 ARO:3005952 OXA-748 OXA-749 is a OXA beta-lactamase. OXA-749 antibiotic_resistance ARO:3005953 OXA-749 ARO:3005953 OXA-749 OXA-750 is a OXA beta-lactamase. OXA-750 antibiotic_resistance ARO:3005954 OXA-750 ARO:3005954 OXA-750 OXA-751 is a OXA beta-lactamase. OXA-751 antibiotic_resistance ARO:3005955 OXA-751 ARO:3005955 OXA-751 OXA-752 is a OXA beta-lactamase. OXA-752 antibiotic_resistance ARO:3005956 OXA-752 ARO:3005956 OXA-752 OXA-753 is a OXA beta-lactamase. OXA-753 antibiotic_resistance ARO:3005957 OXA-753 ARO:3005957 OXA-753 OXA-754 is a OXA beta-lactamase. OXA-754 antibiotic_resistance ARO:3005958 OXA-754 ARO:3005958 OXA-754 OXA-755 is a OXA beta-lactamase. OXA-755 antibiotic_resistance ARO:3005959 OXA-755 ARO:3005959 OXA-755 OXA-756 is a OXA beta-lactamase. OXA-756 antibiotic_resistance ARO:3005960 OXA-756 ARO:3005960 OXA-756 OXA-757 is a OXA beta-lactamase. OXA-757 antibiotic_resistance ARO:3005961 OXA-757 ARO:3005961 OXA-757 OXA-758 is a OXA beta-lactamase. OXA-758 antibiotic_resistance ARO:3005962 OXA-758 ARO:3005962 OXA-758 OXA-759 is a OXA beta-lactamase. OXA-759 antibiotic_resistance ARO:3005963 OXA-759 ARO:3005963 OXA-759 OXA-760 is a OXA beta-lactamase. OXA-760 antibiotic_resistance ARO:3005964 OXA-760 ARO:3005964 OXA-760 OXA-761 is a OXA beta-lactamase. OXA-761 antibiotic_resistance ARO:3005965 OXA-761 ARO:3005965 OXA-761 OXA-762 is a OXA beta-lactamase. OXA-762 antibiotic_resistance ARO:3005966 OXA-762 ARO:3005966 OXA-762 OXA-763 is a OXA beta-lactamase. OXA-763 antibiotic_resistance ARO:3005967 OXA-763 ARO:3005967 OXA-763 OXA-764 is a OXA beta-lactamase. OXA-764 antibiotic_resistance ARO:3005968 OXA-764 ARO:3005968 OXA-764 OXA-765 is a OXA beta-lactamase. OXA-765 antibiotic_resistance ARO:3005969 OXA-765 ARO:3005969 OXA-765 OXA-766 is a OXA beta-lactamase. OXA-766 antibiotic_resistance ARO:3005970 OXA-766 ARO:3005970 OXA-766 OXA-767 is a OXA beta-lactamase. OXA-767 antibiotic_resistance ARO:3005971 OXA-767 ARO:3005971 OXA-767 OXA-768 is a OXA beta-lactamase. OXA-768 antibiotic_resistance ARO:3005972 OXA-768 ARO:3005972 OXA-768 OXA-769 is a OXA beta-lactamase. OXA-769 antibiotic_resistance ARO:3005973 OXA-769 ARO:3005973 OXA-769 OXA-770 is a OXA beta-lactamase. OXA-770 antibiotic_resistance ARO:3005974 OXA-770 ARO:3005974 OXA-770 OXA-771 is a OXA beta-lactamase. OXA-771 antibiotic_resistance ARO:3005975 OXA-771 ARO:3005975 OXA-771 OXA-772 is a OXA beta-lactamase. OXA-772 antibiotic_resistance ARO:3005976 OXA-772 ARO:3005976 OXA-772 OXA-773 is a OXA beta-lactamase. OXA-773 antibiotic_resistance ARO:3005977 OXA-773 ARO:3005977 OXA-773 OXA-774 is a OXA beta-lactamase. OXA-774 antibiotic_resistance ARO:3005978 OXA-774 ARO:3005978 OXA-774 OXA-775 is a OXA beta-lactamase. OXA-775 antibiotic_resistance ARO:3005979 OXA-775 ARO:3005979 OXA-775 OXA-776 is a OXA beta-lactamase. OXA-776 antibiotic_resistance ARO:3005980 OXA-776 ARO:3005980 OXA-776 OXA-777 is a OXA beta-lactamase. OXA-777 antibiotic_resistance ARO:3005981 OXA-777 ARO:3005981 OXA-777 OXA-778 is a OXA beta-lactamase. OXA-778 antibiotic_resistance ARO:3005982 OXA-778 ARO:3005982 OXA-778 OXA-780 is a OXA beta-lactamase. OXA-780 antibiotic_resistance ARO:3005983 OXA-780 ARO:3005983 OXA-780 OXA-781 is a OXA beta-lactamase. OXA-781 antibiotic_resistance ARO:3005984 OXA-781 ARO:3005984 OXA-781 OXA-782 is a OXA beta-lactamase. OXA-782 antibiotic_resistance ARO:3005985 OXA-782 ARO:3005985 OXA-782 OXA-783 is a OXA beta-lactamase. OXA-783 antibiotic_resistance ARO:3005986 OXA-783 ARO:3005986 OXA-783 OXA-784 is a OXA beta-lactamase. OXA-784 antibiotic_resistance ARO:3005987 OXA-784 ARO:3005987 OXA-784 OXA-785 is a OXA beta-lactamase. OXA-785 antibiotic_resistance ARO:3005988 OXA-785 ARO:3005988 OXA-785 OXA-786 is a OXA beta-lactamase. OXA-786 antibiotic_resistance ARO:3005989 OXA-786 ARO:3005989 OXA-786 OXA-787 is a OXA beta-lactamase. OXA-787 antibiotic_resistance ARO:3005990 OXA-787 ARO:3005990 OXA-787 OXA-788 is a OXA beta-lactamase. OXA-788 antibiotic_resistance ARO:3005991 OXA-788 ARO:3005991 OXA-788 OXA-789 is a OXA beta-lactamase. OXA-789 antibiotic_resistance ARO:3005992 OXA-789 ARO:3005992 OXA-789 OXA-793 is a OXA beta-lactamase. OXA-793 antibiotic_resistance ARO:3005993 OXA-793 ARO:3005993 OXA-793 OXA-794 is a OXA beta-lactamase. OXA-794 antibiotic_resistance ARO:3005994 OXA-794 ARO:3005994 OXA-794 OXA-795 is a OXA beta-lactamase. OXA-795 antibiotic_resistance ARO:3005995 OXA-795 ARO:3005995 OXA-795 OXA-796 is a OXA beta-lactamase. OXA-796 antibiotic_resistance ARO:3005996 OXA-796 ARO:3005996 OXA-796 OXA-797 is a OXA beta-lactamase. OXA-797 antibiotic_resistance ARO:3005997 OXA-797 ARO:3005997 OXA-797 OXA-798 is a OXA beta-lactamase. OXA-798 antibiotic_resistance ARO:3005998 OXA-798 ARO:3005998 OXA-798 OXA-799 is a OXA beta-lactamase. OXA-799 antibiotic_resistance ARO:3005999 OXA-799 ARO:3005999 OXA-799 OXA-800 is a OXA beta-lactamase. OXA-800 antibiotic_resistance ARO:3006000 OXA-800 ARO:3006000 OXA-800 OXA-801 is a OXA beta-lactamase. OXA-801 antibiotic_resistance ARO:3006001 OXA-801 ARO:3006001 OXA-801 OXA-802 is a OXA beta-lactamase. OXA-802 antibiotic_resistance ARO:3006002 OXA-802 ARO:3006002 OXA-802 OXA-803 is a OXA beta-lactamase. OXA-803 antibiotic_resistance ARO:3006003 OXA-803 ARO:3006003 OXA-803 OXA-804 is a OXA beta-lactamase. OXA-804 antibiotic_resistance ARO:3006004 OXA-804 ARO:3006004 OXA-804 OXA-805 is a OXA beta-lactamase. OXA-805 antibiotic_resistance ARO:3006005 OXA-805 ARO:3006005 OXA-805 OXA-806 is a OXA beta-lactamase. OXA-806 antibiotic_resistance ARO:3006006 OXA-806 ARO:3006006 OXA-806 OXA-807 is a OXA beta-lactamase. OXA-807 antibiotic_resistance ARO:3006007 OXA-807 ARO:3006007 OXA-807 OXA-808 is a OXA beta-lactamase. OXA-808 antibiotic_resistance ARO:3006008 OXA-808 ARO:3006008 OXA-808 OXA-809 is a OXA beta-lactamase. OXA-809 antibiotic_resistance ARO:3006009 OXA-809 ARO:3006009 OXA-809 OXA-810 is a OXA beta-lactamase. OXA-810 antibiotic_resistance ARO:3006010 OXA-810 ARO:3006010 OXA-810 OXA-811 is a OXA beta-lactamase. OXA-811 antibiotic_resistance ARO:3006011 OXA-811 ARO:3006011 OXA-811 OXA-813 is a OXA beta-lactamase. OXA-813 antibiotic_resistance ARO:3006012 OXA-813 ARO:3006012 OXA-813 OXA-814 is a OXA beta-lactamase. OXA-814 antibiotic_resistance ARO:3006013 OXA-814 ARO:3006013 OXA-814 OXA-815 is a OXA beta-lactamase. OXA-815 antibiotic_resistance ARO:3006014 OXA-815 ARO:3006014 OXA-815 OXA-816 is a OXA beta-lactamase. OXA-816 antibiotic_resistance ARO:3006015 OXA-816 ARO:3006015 OXA-816 OXA-817 is a OXA beta-lactamase. OXA-817 antibiotic_resistance ARO:3006016 OXA-817 ARO:3006016 OXA-817 OXA-819 is a OXA beta-lactamase. OXA-819 antibiotic_resistance ARO:3006017 OXA-819 ARO:3006017 OXA-819 OXA-820 is a OXA beta-lactamase. OXA-820 antibiotic_resistance ARO:3006018 OXA-820 ARO:3006018 OXA-820 OXA-821 is a OXA beta-lactamase. OXA-821 antibiotic_resistance ARO:3006019 OXA-821 ARO:3006019 OXA-821 OXA-822 is a OXA beta-lactamase. OXA-822 antibiotic_resistance ARO:3006020 OXA-822 ARO:3006020 OXA-822 OXA-823 is a OXA beta-lactamase. OXA-823 antibiotic_resistance ARO:3006021 OXA-823 ARO:3006021 OXA-823 OXA-824 is a OXA beta-lactamase. OXA-824 antibiotic_resistance ARO:3006022 OXA-824 ARO:3006022 OXA-824 OXA-826 is a OXA beta-lactamase. OXA-826 antibiotic_resistance ARO:3006023 OXA-826 ARO:3006023 OXA-826 OXA-827 is a OXA beta-lactamase. OXA-827 antibiotic_resistance ARO:3006024 OXA-827 ARO:3006024 OXA-827 OXA-828 is a OXA beta-lactamase. OXA-828 antibiotic_resistance ARO:3006025 OXA-828 ARO:3006025 OXA-828 OXA-829 is a OXA beta-lactamase. OXA-829 antibiotic_resistance ARO:3006026 OXA-829 ARO:3006026 OXA-829 OXA-830 is a OXA beta-lactamase. OXA-830 antibiotic_resistance ARO:3006027 OXA-830 ARO:3006027 OXA-830 OXA-831 is a OXA beta-lactamase. OXA-831 antibiotic_resistance ARO:3006028 OXA-831 ARO:3006028 OXA-831 OXA-832 is a OXA beta-lactamase. OXA-832 antibiotic_resistance ARO:3006029 OXA-832 ARO:3006029 OXA-832 OXA-833 is a OXA beta-lactamase. OXA-833 antibiotic_resistance ARO:3006030 OXA-833 ARO:3006030 OXA-833 OXA-834 is a OXA beta-lactamase. OXA-834 antibiotic_resistance ARO:3006031 OXA-834 ARO:3006031 OXA-834 OXA-836 is a OXA beta-lactamase. OXA-836 antibiotic_resistance ARO:3006032 OXA-836 ARO:3006032 OXA-836 OXA-839 is a OXA beta-lactamase. OXA-839 antibiotic_resistance ARO:3006033 OXA-839 ARO:3006033 OXA-839 OXA-840 is a OXA beta-lactamase. OXA-840 antibiotic_resistance ARO:3006034 OXA-840 ARO:3006034 OXA-840 OXA-841 is a OXA beta-lactamase. OXA-841 antibiotic_resistance ARO:3006035 OXA-841 ARO:3006035 OXA-841 OXA-842 is a OXA beta-lactamase. OXA-842 antibiotic_resistance ARO:3006036 OXA-842 ARO:3006036 OXA-842 OXA-843 is a OXA beta-lactamase. OXA-843 antibiotic_resistance ARO:3006037 OXA-843 ARO:3006037 OXA-843 OXA-844 is a OXA beta-lactamase. OXA-844 antibiotic_resistance ARO:3006038 OXA-844 ARO:3006038 OXA-844 OXA-845 is a OXA beta-lactamase. OXA-845 antibiotic_resistance ARO:3006039 OXA-845 ARO:3006039 OXA-845 OXA-847 is a OXA beta-lactamase. OXA-847 antibiotic_resistance ARO:3006040 OXA-847 ARO:3006040 OXA-847 OXA-848 is a OXA beta-lactamase. OXA-848 antibiotic_resistance ARO:3006041 OXA-848 ARO:3006041 OXA-848 OXA-849 is a OXA beta-lactamase. OXA-849 antibiotic_resistance ARO:3006042 OXA-849 ARO:3006042 OXA-849 OXA-851 is a OXA beta-lactamase. OXA-851 antibiotic_resistance ARO:3006043 OXA-851 ARO:3006043 OXA-851 OXA-852 is a OXA beta-lactamase. OXA-852 antibiotic_resistance ARO:3006044 OXA-852 ARO:3006044 OXA-852 OXA-853 is a OXA beta-lactamase. OXA-853 antibiotic_resistance ARO:3006045 OXA-853 ARO:3006045 OXA-853 OXA-854 is a OXA beta-lactamase. OXA-854 antibiotic_resistance ARO:3006046 OXA-854 ARO:3006046 OXA-854 OXA-855 is a OXA beta-lactamase. OXA-855 antibiotic_resistance ARO:3006047 OXA-855 ARO:3006047 OXA-855 OXA-856 is a OXA beta-lactamase. OXA-856 antibiotic_resistance ARO:3006048 OXA-856 ARO:3006048 OXA-856 OXA-857 is a OXA beta-lactamase. OXA-857 antibiotic_resistance ARO:3006049 OXA-857 ARO:3006049 OXA-857 OXA-858 is a OXA beta-lactamase. OXA-858 antibiotic_resistance ARO:3006050 OXA-858 ARO:3006050 OXA-858 OXA-859 is a OXA beta-lactamase. OXA-859 antibiotic_resistance ARO:3006051 OXA-859 ARO:3006051 OXA-859 OXA-860 is a OXA beta-lactamase. OXA-860 antibiotic_resistance ARO:3006052 OXA-860 ARO:3006052 OXA-860 OXA-861 is a OXA beta-lactamase. OXA-861 antibiotic_resistance ARO:3006053 OXA-861 ARO:3006053 OXA-861 OXA-862 is a OXA beta-lactamase. OXA-862 antibiotic_resistance ARO:3006054 OXA-862 ARO:3006054 OXA-862 OXA-863 is a OXA beta-lactamase. OXA-863 antibiotic_resistance ARO:3006055 OXA-863 ARO:3006055 OXA-863 OXA-864 is a OXA beta-lactamase. OXA-864 antibiotic_resistance ARO:3006056 OXA-864 ARO:3006056 OXA-864 OXA-865 is a OXA beta-lactamase. OXA-865 antibiotic_resistance ARO:3006057 OXA-865 ARO:3006057 OXA-865 OXA-866 is a OXA beta-lactamase. OXA-866 antibiotic_resistance ARO:3006058 OXA-866 ARO:3006058 OXA-866 OXA-867 is a OXA beta-lactamase. OXA-867 antibiotic_resistance ARO:3006059 OXA-867 ARO:3006059 OXA-867 OXA-868 is a OXA beta-lactamase. OXA-868 antibiotic_resistance ARO:3006060 OXA-868 ARO:3006060 OXA-868 OXA-869 is a OXA beta-lactamase. OXA-869 antibiotic_resistance ARO:3006061 OXA-869 ARO:3006061 OXA-869 OXA-870 is a OXA beta-lactamase. OXA-870 antibiotic_resistance ARO:3006062 OXA-870 ARO:3006062 OXA-870 OXA-871 is a OXA beta-lactamase. OXA-871 antibiotic_resistance ARO:3006063 OXA-871 ARO:3006063 OXA-871 OXA-872 is a OXA beta-lactamase. OXA-872 antibiotic_resistance ARO:3006064 OXA-872 ARO:3006064 OXA-872 OXA-873 is a OXA beta-lactamase. OXA-873 antibiotic_resistance ARO:3006065 OXA-873 ARO:3006065 OXA-873 OXA-874 is a OXA beta-lactamase. OXA-874 antibiotic_resistance ARO:3006066 OXA-874 ARO:3006066 OXA-874 OXA-875 is a OXA beta-lactamase. OXA-875 antibiotic_resistance ARO:3006067 OXA-875 ARO:3006067 OXA-875 OXA-876 is a OXA beta-lactamase. OXA-876 antibiotic_resistance ARO:3006068 OXA-876 ARO:3006068 OXA-876 OXA-877 is a OXA beta-lactamase. OXA-877 antibiotic_resistance ARO:3006069 OXA-877 ARO:3006069 OXA-877 OXA-878 is a OXA beta-lactamase. OXA-878 antibiotic_resistance ARO:3006070 OXA-878 ARO:3006070 OXA-878 OXA-879 is a OXA beta-lactamase. OXA-879 antibiotic_resistance ARO:3006071 OXA-879 ARO:3006071 OXA-879 OXA-880 is a OXA beta-lactamase. OXA-880 antibiotic_resistance ARO:3006072 OXA-880 ARO:3006072 OXA-880 OXA-881 is a OXA beta-lactamase. OXA-881 antibiotic_resistance ARO:3006073 OXA-881 ARO:3006073 OXA-881 OXA-882 is a OXA beta-lactamase. OXA-882 antibiotic_resistance ARO:3006074 OXA-882 ARO:3006074 OXA-882 OXA-883 is a OXA beta-lactamase. OXA-883 antibiotic_resistance ARO:3006075 OXA-883 ARO:3006075 OXA-883 OXA-884 is a OXA beta-lactamase. OXA-884 antibiotic_resistance ARO:3006076 OXA-884 ARO:3006076 OXA-884 OXA-885 is a OXA beta-lactamase. OXA-885 antibiotic_resistance ARO:3006077 OXA-885 ARO:3006077 OXA-885 OXA-886 is a OXA beta-lactamase. OXA-886 antibiotic_resistance ARO:3006078 OXA-886 ARO:3006078 OXA-886 OXA-887 is a OXA beta-lactamase. OXA-887 antibiotic_resistance ARO:3006079 OXA-887 ARO:3006079 OXA-887 OXA-888 is a OXA beta-lactamase. OXA-888 antibiotic_resistance ARO:3006080 OXA-888 ARO:3006080 OXA-888 OXA-889 is a OXA beta-lactamase. OXA-889 antibiotic_resistance ARO:3006081 OXA-889 ARO:3006081 OXA-889 OXA-890 is a OXA beta-lactamase. OXA-890 antibiotic_resistance ARO:3006082 OXA-890 ARO:3006082 OXA-890 OXA-891 is a OXA beta-lactamase. OXA-891 antibiotic_resistance ARO:3006083 OXA-891 ARO:3006083 OXA-891 OXA-892 is a OXA beta-lactamase. OXA-892 antibiotic_resistance ARO:3006084 OXA-892 ARO:3006084 OXA-892 OXA-893 is a OXA beta-lactamase. OXA-893 antibiotic_resistance ARO:3006085 OXA-893 ARO:3006085 OXA-893 OXA-894 is a OXA beta-lactamase. OXA-894 antibiotic_resistance ARO:3006086 OXA-894 ARO:3006086 OXA-894 OXA-896 is a OXA beta-lactamase. OXA-896 antibiotic_resistance ARO:3006087 OXA-896 ARO:3006087 OXA-896 OXA-900 is a OXA beta-lactamase. OXA-900 antibiotic_resistance ARO:3006088 OXA-900 ARO:3006088 OXA-900 OXA-901 is a OXA beta-lactamase. OXA-901 antibiotic_resistance ARO:3006089 OXA-901 ARO:3006089 OXA-901 OXA-902 is a OXA beta-lactamase. OXA-902 antibiotic_resistance ARO:3006090 OXA-902 ARO:3006090 OXA-902 OXA-903 is a OXA beta-lactamase. OXA-903 antibiotic_resistance ARO:3006091 OXA-903 ARO:3006091 OXA-903 OXA-904 is a OXA beta-lactamase. OXA-904 antibiotic_resistance ARO:3006092 OXA-904 ARO:3006092 OXA-904 OXA-905 is a OXA beta-lactamase. OXA-905 antibiotic_resistance ARO:3006093 OXA-905 ARO:3006093 OXA-905 OXA-907 is a OXA beta-lactamase. OXA-907 antibiotic_resistance ARO:3006094 OXA-907 ARO:3006094 OXA-907 OXA-908 is a OXA beta-lactamase. OXA-908 antibiotic_resistance ARO:3006095 OXA-908 ARO:3006095 OXA-908 OXA-909 is a OXA beta-lactamase. OXA-909 antibiotic_resistance ARO:3006096 OXA-909 ARO:3006096 OXA-909 OXA-910 is a OXA beta-lactamase. OXA-910 antibiotic_resistance ARO:3006097 OXA-910 ARO:3006097 OXA-910 OXA-911 is a OXA beta-lactamase. OXA-911 antibiotic_resistance ARO:3006098 OXA-911 ARO:3006098 OXA-911 OXA-912 is a OXA beta-lactamase. OXA-912 antibiotic_resistance ARO:3006099 OXA-912 ARO:3006099 OXA-912 OXA-913 is a OXA beta-lactamase. OXA-913 antibiotic_resistance ARO:3006100 OXA-913 ARO:3006100 OXA-913 OXA-914 is a OXA beta-lactamase. OXA-914 antibiotic_resistance ARO:3006101 OXA-914 ARO:3006101 OXA-914 OXA-916 is a OXA beta-lactamase. OXA-916 antibiotic_resistance ARO:3006102 OXA-916 ARO:3006102 OXA-916 OXA-917 is a OXA beta-lactamase. OXA-917 antibiotic_resistance ARO:3006103 OXA-917 ARO:3006103 OXA-917 OXA-918 is a OXA beta-lactamase. OXA-918 antibiotic_resistance ARO:3006104 OXA-918 ARO:3006104 OXA-918 OXA-919 is a OXA beta-lactamase. OXA-919 antibiotic_resistance ARO:3006105 OXA-919 ARO:3006105 OXA-919 OXA-920 is a OXA beta-lactamase. OXA-920 antibiotic_resistance ARO:3006106 OXA-920 ARO:3006106 OXA-920 OXA-921 is a OXA beta-lactamase. OXA-921 antibiotic_resistance ARO:3006107 OXA-921 ARO:3006107 OXA-921 OXA-922 is a OXA beta-lactamase. OXA-922 antibiotic_resistance ARO:3006108 OXA-922 ARO:3006108 OXA-922 OXA-923 is a OXA beta-lactamase. OXA-923 antibiotic_resistance ARO:3006109 OXA-923 ARO:3006109 OXA-923 OXA-924 is a OXA beta-lactamase. OXA-924 antibiotic_resistance ARO:3006110 OXA-924 ARO:3006110 OXA-924 OXA-925 is a OXA beta-lactamase. OXA-925 antibiotic_resistance ARO:3006111 OXA-925 ARO:3006111 OXA-925 OXA-927 is a OXA beta-lactamase. OXA-927 antibiotic_resistance ARO:3006112 OXA-927 ARO:3006112 OXA-927 OXA-928 is a OXA beta-lactamase. OXA-928 antibiotic_resistance ARO:3006113 OXA-928 ARO:3006113 OXA-928 OXA-929 is a OXA beta-lactamase. OXA-929 antibiotic_resistance ARO:3006114 OXA-929 ARO:3006114 OXA-929 OXA-932 is a OXA beta-lactamase. OXA-932 antibiotic_resistance ARO:3006115 OXA-932 ARO:3006115 OXA-932 OXA-935 is a OXA beta-lactamase. OXA-935 antibiotic_resistance ARO:3006116 OXA-935 ARO:3006116 OXA-935 OXA-937 is a OXA beta-lactamase. OXA-937 antibiotic_resistance ARO:3006117 OXA-937 ARO:3006117 OXA-937 OXA-938 is a OXA beta-lactamase. OXA-938 antibiotic_resistance ARO:3006118 OXA-938 ARO:3006118 OXA-938 OXA-939 is a OXA beta-lactamase. OXA-939 antibiotic_resistance ARO:3006119 OXA-939 ARO:3006119 OXA-939 OXA-940 is a OXA beta-lactamase. OXA-940 antibiotic_resistance ARO:3006120 OXA-940 ARO:3006120 OXA-940 OXA-941 is a OXA beta-lactamase. OXA-941 antibiotic_resistance ARO:3006121 OXA-941 ARO:3006121 OXA-941 OXA-942 is a OXA beta-lactamase. OXA-942 antibiotic_resistance ARO:3006122 OXA-942 ARO:3006122 OXA-942 OXA-943 is a OXA beta-lactamase. OXA-943 antibiotic_resistance ARO:3006123 OXA-943 ARO:3006123 OXA-943 OXA-945 is a OXA beta-lactamase. OXA-945 antibiotic_resistance ARO:3006124 OXA-945 ARO:3006124 OXA-945 OXA-946 is a OXA beta-lactamase. OXA-946 antibiotic_resistance ARO:3006125 OXA-946 ARO:3006125 OXA-946 OXA-947 is a OXA beta-lactamase. OXA-947 antibiotic_resistance ARO:3006126 OXA-947 ARO:3006126 OXA-947 OXA-948 is a OXA beta-lactamase. OXA-948 antibiotic_resistance ARO:3006127 OXA-948 ARO:3006127 OXA-948 OXA-949 is a OXA beta-lactamase. OXA-949 antibiotic_resistance ARO:3006128 OXA-949 ARO:3006128 OXA-949 OXY-2-14 is a OXY beta-lactamase. OXY-2-14 antibiotic_resistance ARO:3006129 OXY-2-14 ARO:3006129 OXY-2-14 OXY-2-15 is a OXY beta-lactamase. OXY-2-15 antibiotic_resistance ARO:3006130 OXY-2-15 ARO:3006130 OXY-2-15 PER-10 is a PER beta-lactamase. PER-10 antibiotic_resistance ARO:3006131 PER-10 ARO:3006131 PER-10 PER-11 is a PER beta-lactamase. PER-11 antibiotic_resistance ARO:3006132 PER-11 ARO:3006132 PER-11 PER-12 is a PER beta-lactamase. PER-12 antibiotic_resistance ARO:3006133 PER-12 ARO:3006133 PER-12 PER-13 is a PER beta-lactamase. PER-13 antibiotic_resistance ARO:3006134 PER-13 ARO:3006134 PER-13 PER-14 is a PER beta-lactamase. PER-14 antibiotic_resistance ARO:3006135 PER-14 ARO:3006135 PER-14 PER-15 is a PER beta-lactamase. PER-15 antibiotic_resistance ARO:3006136 PER-15 ARO:3006136 PER-15 PER-16 is a PER beta-lactamase. PER-16 antibiotic_resistance ARO:3006137 PER-16 ARO:3006137 PER-16 PER-9 is a PER beta-lactamase. PER-9 antibiotic_resistance ARO:3006138 PER-9 ARO:3006138 PER-9 TEM-98 is a TEM beta-lactamase. TEM-98 antibiotic_resistance ARO:3006139 TEM-98 ARO:3006139 TEM-98 TEM-99 is a TEM beta-lactamase. TEM-99 antibiotic_resistance ARO:3006140 TEM-99 ARO:3006140 TEM-99 OKP-A-17 is a OKP beta-lactamase. OKP-A-17 antibiotic_resistance ARO:3006141 OKP-A-17 ARO:3006141 OKP-A-17 OKP-B-16 is a OKP beta-lactamase. OKP-B-16 antibiotic_resistance ARO:3006142 OKP-B-16 ARO:3006142 OKP-B-16 OKP-B-21 is a OKP beta-lactamase. OKP-B-21 antibiotic_resistance ARO:3006143 OKP-B-21 ARO:3006143 OKP-B-21 OKP-B-22 is a OKP beta-lactamase. OKP-B-22 antibiotic_resistance ARO:3006144 OKP-B-22 ARO:3006144 OKP-B-22 OKP-B-23 is a OKP beta-lactamase. OKP-B-23 antibiotic_resistance ARO:3006145 OKP-B-23 ARO:3006145 OKP-B-23 OKP-B-24 is a OKP beta-lactamase. OKP-B-24 antibiotic_resistance ARO:3006146 OKP-B-24 ARO:3006146 OKP-B-24 OKP-B-34 is a OKP beta-lactamase. OKP-B-34 antibiotic_resistance ARO:3006147 OKP-B-34 ARO:3006147 OKP-B-34 OKP-B-36 is a OKP beta-lactamase. OKP-B-36 antibiotic_resistance ARO:3006148 OKP-B-36 ARO:3006148 OKP-B-36 OKP-B-40 is a OKP beta-lactamase. OKP-B-40 antibiotic_resistance ARO:3006149 OKP-B-40 ARO:3006149 OKP-B-40 OKP-B-41 is a OKP beta-lactamase. OKP-B-41 antibiotic_resistance ARO:3006150 OKP-B-41 ARO:3006150 OKP-B-41 OKP-B-45 is a OKP beta-lactamase. OKP-B-45 antibiotic_resistance ARO:3006151 OKP-B-45 ARO:3006151 OKP-B-45 OKP-C-1 is a OKP beta-lactamase. OKP-C-1 antibiotic_resistance ARO:3006152 OKP-C-1 ARO:3006152 OKP-C-1 OKP-D-1 is a OKP beta-lactamase. OKP-D-1 antibiotic_resistance ARO:3006153 OKP-D-1 ARO:3006153 OKP-D-1 BEL-4 is a BEL beta-lactamase. BEL-4 antibiotic_resistance ARO:3006154 BEL-4 ARO:3006154 BEL-4 CME-2 is a CME beta-lactamase. CME-2 antibiotic_resistance ARO:3006155 CME-2 ARO:3006155 CME-2 GES-27 is a GES beta-lactamase. GES-27 antibiotic_resistance ARO:3006156 GES-27 ARO:3006156 GES-27 GES-28 is a GES beta-lactamase. GES-28 antibiotic_resistance ARO:3006157 GES-28 ARO:3006157 GES-28 GES-29 is a GES beta-lactamase. GES-29 antibiotic_resistance ARO:3006158 GES-29 ARO:3006158 GES-29 GES-30 is a GES beta-lactamase. GES-30 antibiotic_resistance ARO:3006159 GES-30 ARO:3006159 GES-30 GES-31 is a GES beta-lactamase. GES-31 antibiotic_resistance ARO:3006160 GES-31 ARO:3006160 GES-31 GES-32 is a GES beta-lactamase. GES-32 antibiotic_resistance ARO:3006161 GES-32 ARO:3006161 GES-32 GES-33 is a GES beta-lactamase. GES-33 antibiotic_resistance ARO:3006162 GES-33 ARO:3006162 GES-33 GES-34 is a GES beta-lactamase. GES-34 antibiotic_resistance ARO:3006163 GES-34 ARO:3006163 GES-34 GES-35 is a GES beta-lactamase. GES-35 antibiotic_resistance ARO:3006164 GES-35 ARO:3006164 GES-35 GES-36 is a GES beta-lactamase. GES-36 antibiotic_resistance ARO:3006165 GES-36 ARO:3006165 GES-36 GES-37 is a GES beta-lactamase. GES-37 antibiotic_resistance ARO:3006166 GES-37 ARO:3006166 GES-37 GES-38 is a GES beta-lactamase. GES-38 antibiotic_resistance ARO:3006167 GES-38 ARO:3006167 GES-38 GES-39 is a GES beta-lactamase. GES-39 antibiotic_resistance ARO:3006168 GES-39 ARO:3006168 GES-39 GES-40 is a GES beta-lactamase. GES-40 antibiotic_resistance ARO:3006169 GES-40 ARO:3006169 GES-40 GES-41 is a GES beta-lactamase. GES-41 antibiotic_resistance ARO:3006170 GES-41 ARO:3006170 GES-41 GES-42 is a GES beta-lactamase. GES-42 antibiotic_resistance ARO:3006171 GES-42 ARO:3006171 GES-42 GES-43 is a GES beta-lactamase. GES-43 antibiotic_resistance ARO:3006172 GES-43 ARO:3006172 GES-43 GES-44 is a GES beta-lactamase. GES-44 antibiotic_resistance ARO:3006173 GES-44 ARO:3006173 GES-44 GES-45 is a GES beta-lactamase. GES-45 antibiotic_resistance ARO:3006174 GES-45 ARO:3006174 GES-45 GES-46 is a GES beta-lactamase. GES-46 antibiotic_resistance ARO:3006175 GES-46 ARO:3006175 GES-46 IMI-12 is a IMI beta-lactamase. IMI-12 antibiotic_resistance ARO:3006176 IMI-12 ARO:3006176 IMI-12 IMI-13 is a IMI beta-lactamase. IMI-13 antibiotic_resistance ARO:3006177 IMI-13 ARO:3006177 IMI-13 IMI-14 is a IMI beta-lactamase. IMI-14 antibiotic_resistance ARO:3006178 IMI-14 ARO:3006178 IMI-14 IMI-15 is a IMI beta-lactamase. IMI-15 antibiotic_resistance ARO:3006179 IMI-15 ARO:3006179 IMI-15 IMI-16 is a IMI beta-lactamase. IMI-16 antibiotic_resistance ARO:3006180 IMI-16 ARO:3006180 IMI-16 IMI-17 is a IMI beta-lactamase. IMI-17 antibiotic_resistance ARO:3006181 IMI-17 ARO:3006181 IMI-17 IMI-18 is a IMI beta-lactamase. IMI-18 antibiotic_resistance ARO:3006182 IMI-18 ARO:3006182 IMI-18 IMI-19 is a IMI beta-lactamase. IMI-19 antibiotic_resistance ARO:3006183 IMI-19 ARO:3006183 IMI-19 IMI-20 is a IMI beta-lactamase. IMI-20 antibiotic_resistance ARO:3006184 IMI-20 ARO:3006184 IMI-20 IMI-21 is a IMI beta-lactamase. IMI-21 antibiotic_resistance ARO:3006185 IMI-21 ARO:3006185 IMI-21 KPC-44 is a KPC beta-lactamase. KPC-44 antibiotic_resistance ARO:3006186 KPC-44 ARO:3006186 KPC-44 KPC-58 is a KPC beta-lactamase. KPC-58 antibiotic_resistance ARO:3006187 KPC-58 ARO:3006187 KPC-58 KPC-59 is a KPC beta-lactamase. KPC-59 antibiotic_resistance ARO:3006188 KPC-59 ARO:3006188 KPC-59 KPC-60 is a KPC beta-lactamase. KPC-60 antibiotic_resistance ARO:3006189 KPC-60 ARO:3006189 KPC-60 KPC-61 is a KPC beta-lactamase. KPC-61 antibiotic_resistance ARO:3006190 KPC-61 ARO:3006190 KPC-61 KPC-62 is a KPC beta-lactamase. KPC-62 antibiotic_resistance ARO:3006191 KPC-62 ARO:3006191 KPC-62 KPC-63 is a KPC beta-lactamase. KPC-63 antibiotic_resistance ARO:3006192 KPC-63 ARO:3006192 KPC-63 KPC-64 is a KPC beta-lactamase. KPC-64 antibiotic_resistance ARO:3006193 KPC-64 ARO:3006193 KPC-64 KPC-65 is a KPC beta-lactamase. KPC-65 antibiotic_resistance ARO:3006194 KPC-65 ARO:3006194 KPC-65 KPC-66 is a KPC beta-lactamase. KPC-66 antibiotic_resistance ARO:3006195 KPC-66 ARO:3006195 KPC-66 KPC-71 is a KPC beta-lactamase. KPC-71 antibiotic_resistance ARO:3006196 KPC-71 ARO:3006196 KPC-71 KPC-72 is a KPC beta-lactamase. KPC-72 antibiotic_resistance ARO:3006197 KPC-72 ARO:3006197 KPC-72 KPC-73 is a KPC beta-lactamase. KPC-73 antibiotic_resistance ARO:3006198 KPC-73 ARO:3006198 KPC-73 KPC-74 is a KPC beta-lactamase. KPC-74 antibiotic_resistance ARO:3006199 KPC-74 ARO:3006199 KPC-74 KPC-75 is a KPC beta-lactamase. KPC-75 antibiotic_resistance ARO:3006200 KPC-75 ARO:3006200 KPC-75 KPC-76 is a KPC beta-lactamase. KPC-76 antibiotic_resistance ARO:3006201 KPC-76 ARO:3006201 KPC-76 KPC-77 is a KPC beta-lactamase. KPC-77 antibiotic_resistance ARO:3006202 KPC-77 ARO:3006202 KPC-77 KPC-78 is a KPC beta-lactamase. KPC-78 antibiotic_resistance ARO:3006203 KPC-78 ARO:3006203 KPC-78 KPC-79 is a KPC beta-lactamase. KPC-79 antibiotic_resistance ARO:3006204 KPC-79 ARO:3006204 KPC-79 KPC-80 is a KPC beta-lactamase. KPC-80 antibiotic_resistance ARO:3006205 KPC-80 ARO:3006205 KPC-80 KPC-81 is a KPC beta-lactamase. KPC-81 antibiotic_resistance ARO:3006206 KPC-81 ARO:3006206 KPC-81 KPC-82 is a KPC beta-lactamase. KPC-82 antibiotic_resistance ARO:3006207 KPC-82 ARO:3006207 KPC-82 VEB-11 is a VEB beta-lactamase. VEB-11 antibiotic_resistance ARO:3006208 VEB-11 ARO:3006208 VEB-11 VEB-12 is a VEB beta-lactamase. VEB-12 antibiotic_resistance ARO:3006209 VEB-12 ARO:3006209 VEB-12 VEB-13 is a VEB beta-lactamase. VEB-13 antibiotic_resistance ARO:3006210 VEB-13 ARO:3006210 VEB-13 VEB-14 is a VEB beta-lactamase. VEB-14 antibiotic_resistance ARO:3006211 VEB-14 ARO:3006211 VEB-14 VEB-15 is a VEB beta-lactamase. VEB-15 antibiotic_resistance ARO:3006212 VEB-15 ARO:3006212 VEB-15 VEB-17 is a VEB beta-lactamase. VEB-17 antibiotic_resistance ARO:3006213 VEB-17 ARO:3006213 VEB-17 VEB-19 is a VEB beta-lactamase. VEB-19 antibiotic_resistance ARO:3006214 VEB-19 ARO:3006214 VEB-19 VEB-20 is a VEB beta-lactamase. VEB-20 antibiotic_resistance ARO:3006215 VEB-20 ARO:3006215 VEB-20 VEB-21 is a VEB beta-lactamase. VEB-21 antibiotic_resistance ARO:3006216 VEB-21 ARO:3006216 VEB-21 VEB-22 is a VEB beta-lactamase. VEB-22 antibiotic_resistance ARO:3006217 VEB-22 ARO:3006217 VEB-22 VEB-23 is a VEB beta-lactamase. VEB-23 antibiotic_resistance ARO:3006218 VEB-23 ARO:3006218 VEB-23 VEB-24 is a VEB beta-lactamase. VEB-24 antibiotic_resistance ARO:3006219 VEB-24 ARO:3006219 VEB-24 VEB-25 is a VEB beta-lactamase. VEB-25 antibiotic_resistance ARO:3006220 VEB-25 ARO:3006220 VEB-25 VEB-26 is a VEB beta-lactamase. VEB-26 antibiotic_resistance ARO:3006221 VEB-26 ARO:3006221 VEB-26 VEB-27 is a VEB beta-lactamase. VEB-27 antibiotic_resistance ARO:3006222 VEB-27 ARO:3006222 VEB-27 BKC-2 is a BKC beta-lactamase. BKC-2 antibiotic_resistance ARO:3006223 BKC-2 ARO:3006223 BKC-2 CepA-29 is a CepA beta-lactamase. CepA-29 antibiotic_resistance ARO:3006224 CepA-29 ARO:3006224 CepA-29 CepA-44 is a CepA beta-lactamase. CepA-44 antibiotic_resistance ARO:3006225 CepA-44 ARO:3006225 CepA-44 CepA-49 is a CepA beta-lactamase. CepA-49 antibiotic_resistance ARO:3006226 CepA-49 ARO:3006226 CepA-49 FRI-10 is a FRI beta-lactamase. FRI-10 antibiotic_resistance ARO:3006227 FRI-10 ARO:3006227 FRI-10 ACC-1a is a ACC beta-lactamase. ACC-1a antibiotic_resistance ARO:3006228 ACC-1a ARO:3006228 ACC-1a ACC-1b is a ACC beta-lactamase. ACC-1b antibiotic_resistance ARO:3006229 ACC-1b ARO:3006229 ACC-1b ACC-1c is a ACC beta-lactamase. ACC-1c antibiotic_resistance ARO:3006230 ACC-1c ARO:3006230 ACC-1c ACC-1d is a ACC beta-lactamase. ACC-1d antibiotic_resistance ARO:3006231 ACC-1d ARO:3006231 ACC-1d ACC-7 is a ACC beta-lactamase. ACC-7 antibiotic_resistance ARO:3006232 ACC-7 ARO:3006232 ACC-7 ACC-8 is a ACC beta-lactamase. ACC-8 antibiotic_resistance ARO:3006233 ACC-8 ARO:3006233 ACC-8 ACT-39 is a ACT beta-lactamase. ACT-39 antibiotic_resistance ARO:3006234 ACT-39 ARO:3006234 ACT-39 ACT-40 is a ACT beta-lactamase. ACT-40 antibiotic_resistance ARO:3006235 ACT-40 ARO:3006235 ACT-40 ACT-41 is a ACT beta-lactamase. ACT-41 antibiotic_resistance ARO:3006236 ACT-41 ARO:3006236 ACT-41 ACT-42 is a ACT beta-lactamase. ACT-42 antibiotic_resistance ARO:3006237 ACT-42 ARO:3006237 ACT-42 ACT-43 is a ACT beta-lactamase. ACT-43 antibiotic_resistance ARO:3006238 ACT-43 ARO:3006238 ACT-43 ACT-44 is a ACT beta-lactamase. ACT-44 antibiotic_resistance ARO:3006239 ACT-44 ARO:3006239 ACT-44 ACT-45 is a ACT beta-lactamase. ACT-45 antibiotic_resistance ARO:3006240 ACT-45 ARO:3006240 ACT-45 ACT-46 is a ACT beta-lactamase. ACT-46 antibiotic_resistance ARO:3006241 ACT-46 ARO:3006241 ACT-46 ACT-47 is a ACT beta-lactamase. ACT-47 antibiotic_resistance ARO:3006242 ACT-47 ARO:3006242 ACT-47 ACT-48 is a ACT beta-lactamase. ACT-48 antibiotic_resistance ARO:3006243 ACT-48 ARO:3006243 ACT-48 ACT-49 is a ACT beta-lactamase. ACT-49 antibiotic_resistance ARO:3006244 ACT-49 ARO:3006244 ACT-49 ACT-50 is a ACT beta-lactamase. ACT-50 antibiotic_resistance ARO:3006245 ACT-50 ARO:3006245 ACT-50 ACT-51 is a ACT beta-lactamase. ACT-51 antibiotic_resistance ARO:3006246 ACT-51 ARO:3006246 ACT-51 ACT-52 is a ACT beta-lactamase. ACT-52 antibiotic_resistance ARO:3006247 ACT-52 ARO:3006247 ACT-52 ACT-53 is a ACT beta-lactamase. ACT-53 antibiotic_resistance ARO:3006248 ACT-53 ARO:3006248 ACT-53 ACT-54 is a ACT beta-lactamase. ACT-54 antibiotic_resistance ARO:3006249 ACT-54 ARO:3006249 ACT-54 ACT-55 is a ACT beta-lactamase. ACT-55 antibiotic_resistance ARO:3006250 ACT-55 ARO:3006250 ACT-55 ACT-56 is a ACT beta-lactamase. ACT-56 antibiotic_resistance ARO:3006251 ACT-56 ARO:3006251 ACT-56 ACT-57 is a ACT beta-lactamase. ACT-57 antibiotic_resistance ARO:3006252 ACT-57 ARO:3006252 ACT-57 ACT-58 is a ACT beta-lactamase. ACT-58 antibiotic_resistance ARO:3006253 ACT-58 ARO:3006253 ACT-58 ACT-59 is a ACT beta-lactamase. ACT-59 antibiotic_resistance ARO:3006254 ACT-59 ARO:3006254 ACT-59 ACT-60 is a ACT beta-lactamase. ACT-60 antibiotic_resistance ARO:3006255 ACT-60 ARO:3006255 ACT-60 ACT-61 is a ACT beta-lactamase. ACT-61 antibiotic_resistance ARO:3006256 ACT-61 ARO:3006256 ACT-61 ACT-62 is a ACT beta-lactamase. ACT-62 antibiotic_resistance ARO:3006257 ACT-62 ARO:3006257 ACT-62 ACT-63 is a ACT beta-lactamase. ACT-63 antibiotic_resistance ARO:3006258 ACT-63 ARO:3006258 ACT-63 ACT-64 is a ACT beta-lactamase. ACT-64 antibiotic_resistance ARO:3006259 ACT-64 ARO:3006259 ACT-64 ACT-65 is a ACT beta-lactamase. ACT-65 antibiotic_resistance ARO:3006260 ACT-65 ARO:3006260 ACT-65 ACT-66 is a ACT beta-lactamase. ACT-66 antibiotic_resistance ARO:3006261 ACT-66 ARO:3006261 ACT-66 ACT-67 is a ACT beta-lactamase. ACT-67 antibiotic_resistance ARO:3006262 ACT-67 ARO:3006262 ACT-67 ACT-68 is a ACT beta-lactamase. ACT-68 antibiotic_resistance ARO:3006263 ACT-68 ARO:3006263 ACT-68 ACT-69 is a ACT beta-lactamase. ACT-69 antibiotic_resistance ARO:3006264 ACT-69 ARO:3006264 ACT-69 ACT-70 is a ACT beta-lactamase. ACT-70 antibiotic_resistance ARO:3006265 ACT-70 ARO:3006265 ACT-70 ACT-72 is a ACT beta-lactamase. ACT-72 antibiotic_resistance ARO:3006266 ACT-72 ARO:3006266 ACT-72 ACT-73 is a ACT beta-lactamase. ACT-73 antibiotic_resistance ARO:3006267 ACT-73 ARO:3006267 ACT-73 ACT-74 is a ACT beta-lactamase. ACT-74 antibiotic_resistance ARO:3006268 ACT-74 ARO:3006268 ACT-74 ACT-75 is a ACT beta-lactamase. ACT-75 antibiotic_resistance ARO:3006269 ACT-75 ARO:3006269 ACT-75 ACT-76 is a ACT beta-lactamase. ACT-76 antibiotic_resistance ARO:3006270 ACT-76 ARO:3006270 ACT-76 ACT-77 is a ACT beta-lactamase. ACT-77 antibiotic_resistance ARO:3006271 ACT-77 ARO:3006271 ACT-77 ACT-78 is a ACT beta-lactamase. ACT-78 antibiotic_resistance ARO:3006272 ACT-78 ARO:3006272 ACT-78 ACT-79 is a ACT beta-lactamase. ACT-79 antibiotic_resistance ARO:3006273 ACT-79 ARO:3006273 ACT-79 ACT-80 is a ACT beta-lactamase. ACT-80 antibiotic_resistance ARO:3006274 ACT-80 ARO:3006274 ACT-80 ACT-81 is a ACT beta-lactamase. ACT-81 antibiotic_resistance ARO:3006275 ACT-81 ARO:3006275 ACT-81 ACT-82 is a ACT beta-lactamase. ACT-82 antibiotic_resistance ARO:3006276 ACT-82 ARO:3006276 ACT-82 ACT-83 is a ACT beta-lactamase. ACT-83 antibiotic_resistance ARO:3006277 ACT-83 ARO:3006277 ACT-83 ACT-84 is a ACT beta-lactamase. ACT-84 antibiotic_resistance ARO:3006278 ACT-84 ARO:3006278 ACT-84 ACT-87 is a ACT beta-lactamase. ACT-87 antibiotic_resistance ARO:3006279 ACT-87 ARO:3006279 ACT-87 ADC-100 is a ADC beta-lactamase. ADC-100 antibiotic_resistance ARO:3006280 ADC-100 ARO:3006280 ADC-100 ADC-101 is a ADC beta-lactamase. ADC-101 antibiotic_resistance ARO:3006281 ADC-101 ARO:3006281 ADC-101 ADC-102 is a ADC beta-lactamase. ADC-102 antibiotic_resistance ARO:3006282 ADC-102 ARO:3006282 ADC-102 ADC-103 is a ADC beta-lactamase. ADC-103 antibiotic_resistance ARO:3006283 ADC-103 ARO:3006283 ADC-103 ADC-104 is a ADC beta-lactamase. ADC-104 antibiotic_resistance ARO:3006284 ADC-104 ARO:3006284 ADC-104 ADC-105 is a ADC beta-lactamase. ADC-105 antibiotic_resistance ARO:3006285 ADC-105 ARO:3006285 ADC-105 ADC-106 is a ADC beta-lactamase. ADC-106 antibiotic_resistance ARO:3006286 ADC-106 ARO:3006286 ADC-106 ADC-107 is a ADC beta-lactamase. ADC-107 antibiotic_resistance ARO:3006287 ADC-107 ARO:3006287 ADC-107 ADC-109 is a ADC beta-lactamase. ADC-109 antibiotic_resistance ARO:3006288 ADC-109 ARO:3006288 ADC-109 ADC-110 is a ADC beta-lactamase. ADC-110 antibiotic_resistance ARO:3006289 ADC-110 ARO:3006289 ADC-110 ADC-112 is a ADC beta-lactamase. ADC-112 antibiotic_resistance ARO:3006290 ADC-112 ARO:3006290 ADC-112 ADC-113 is a ADC beta-lactamase. ADC-113 antibiotic_resistance ARO:3006291 ADC-113 ARO:3006291 ADC-113 ADC-114 is a ADC beta-lactamase. ADC-114 antibiotic_resistance ARO:3006292 ADC-114 ARO:3006292 ADC-114 ADC-115 is a ADC beta-lactamase. ADC-115 antibiotic_resistance ARO:3006293 ADC-115 ARO:3006293 ADC-115 ADC-116 is a ADC beta-lactamase. ADC-116 antibiotic_resistance ARO:3006294 ADC-116 ARO:3006294 ADC-116 ADC-117 is a ADC beta-lactamase. ADC-117 antibiotic_resistance ARO:3006295 ADC-117 ARO:3006295 ADC-117 ADC-119 is a ADC beta-lactamase. ADC-119 antibiotic_resistance ARO:3006296 ADC-119 ARO:3006296 ADC-119 ADC-120 is a ADC beta-lactamase. ADC-120 antibiotic_resistance ARO:3006297 ADC-120 ARO:3006297 ADC-120 ADC-121 is a ADC beta-lactamase. ADC-121 antibiotic_resistance ARO:3006298 ADC-121 ARO:3006298 ADC-121 ADC-122 is a ADC beta-lactamase. ADC-122 antibiotic_resistance ARO:3006299 ADC-122 ARO:3006299 ADC-122 ADC-123 is a ADC beta-lactamase. ADC-123 antibiotic_resistance ARO:3006300 ADC-123 ARO:3006300 ADC-123 ADC-125 is a ADC beta-lactamase. ADC-125 antibiotic_resistance ARO:3006301 ADC-125 ARO:3006301 ADC-125 ADC-127 is a ADC beta-lactamase. ADC-127 antibiotic_resistance ARO:3006302 ADC-127 ARO:3006302 ADC-127 ADC-128 is a ADC beta-lactamase. ADC-128 antibiotic_resistance ARO:3006303 ADC-128 ARO:3006303 ADC-128 ADC-129 is a ADC beta-lactamase. ADC-129 antibiotic_resistance ARO:3006304 ADC-129 ARO:3006304 ADC-129 ADC-130 is a ADC beta-lactamase. ADC-130 antibiotic_resistance ARO:3006305 ADC-130 ARO:3006305 ADC-130 ADC-131 is a ADC beta-lactamase. ADC-131 antibiotic_resistance ARO:3006306 ADC-131 ARO:3006306 ADC-131 ADC-132 is a ADC beta-lactamase. ADC-132 antibiotic_resistance ARO:3006307 ADC-132 ARO:3006307 ADC-132 ADC-133 is a ADC beta-lactamase. ADC-133 antibiotic_resistance ARO:3006308 ADC-133 ARO:3006308 ADC-133 ADC-134 is a ADC beta-lactamase. ADC-134 antibiotic_resistance ARO:3006309 ADC-134 ARO:3006309 ADC-134 ADC-135 is a ADC beta-lactamase. ADC-135 antibiotic_resistance ARO:3006310 ADC-135 ARO:3006310 ADC-135 ADC-136 is a ADC beta-lactamase. ADC-136 antibiotic_resistance ARO:3006311 ADC-136 ARO:3006311 ADC-136 ADC-137 is a ADC beta-lactamase. ADC-137 antibiotic_resistance ARO:3006312 ADC-137 ARO:3006312 ADC-137 ADC-138 is a ADC beta-lactamase. ADC-138 antibiotic_resistance ARO:3006313 ADC-138 ARO:3006313 ADC-138 ADC-139 is a ADC beta-lactamase. ADC-139 antibiotic_resistance ARO:3006314 ADC-139 ARO:3006314 ADC-139 ADC-140 is a ADC beta-lactamase. ADC-140 antibiotic_resistance ARO:3006315 ADC-140 ARO:3006315 ADC-140 ADC-141 is a ADC beta-lactamase. ADC-141 antibiotic_resistance ARO:3006316 ADC-141 ARO:3006316 ADC-141 ADC-143 is a ADC beta-lactamase. ADC-143 antibiotic_resistance ARO:3006317 ADC-143 ARO:3006317 ADC-143 ADC-144 is a ADC beta-lactamase. ADC-144 antibiotic_resistance ARO:3006318 ADC-144 ARO:3006318 ADC-144 ADC-145 is a ADC beta-lactamase. ADC-145 antibiotic_resistance ARO:3006319 ADC-145 ARO:3006319 ADC-145 ADC-146 is a ADC beta-lactamase. ADC-146 antibiotic_resistance ARO:3006320 ADC-146 ARO:3006320 ADC-146 ADC-147 is a ADC beta-lactamase. ADC-147 antibiotic_resistance ARO:3006321 ADC-147 ARO:3006321 ADC-147 ADC-148 is a ADC beta-lactamase. ADC-148 antibiotic_resistance ARO:3006322 ADC-148 ARO:3006322 ADC-148 ADC-149 is a ADC beta-lactamase. ADC-149 antibiotic_resistance ARO:3006323 ADC-149 ARO:3006323 ADC-149 ADC-150 is a ADC beta-lactamase. ADC-150 antibiotic_resistance ARO:3006324 ADC-150 ARO:3006324 ADC-150 ADC-151 is a ADC beta-lactamase. ADC-151 antibiotic_resistance ARO:3006325 ADC-151 ARO:3006325 ADC-151 ADC-152 is a ADC beta-lactamase. ADC-152 antibiotic_resistance ARO:3006326 ADC-152 ARO:3006326 ADC-152 ADC-153 is a ADC beta-lactamase. ADC-153 antibiotic_resistance ARO:3006327 ADC-153 ARO:3006327 ADC-153 ADC-154 is a ADC beta-lactamase. ADC-154 antibiotic_resistance ARO:3006328 ADC-154 ARO:3006328 ADC-154 ADC-155 is a ADC beta-lactamase. ADC-155 antibiotic_resistance ARO:3006329 ADC-155 ARO:3006329 ADC-155 ADC-156 is a ADC beta-lactamase. ADC-156 antibiotic_resistance ARO:3006330 ADC-156 ARO:3006330 ADC-156 ADC-157 is a ADC beta-lactamase. ADC-157 antibiotic_resistance ARO:3006331 ADC-157 ARO:3006331 ADC-157 ADC-158 is a ADC beta-lactamase. ADC-158 antibiotic_resistance ARO:3006332 ADC-158 ARO:3006332 ADC-158 ADC-160 is a ADC beta-lactamase. ADC-160 antibiotic_resistance ARO:3006333 ADC-160 ARO:3006333 ADC-160 ADC-162 is a ADC beta-lactamase. ADC-162 antibiotic_resistance ARO:3006334 ADC-162 ARO:3006334 ADC-162 ADC-163 is a ADC beta-lactamase. ADC-163 antibiotic_resistance ARO:3006335 ADC-163 ARO:3006335 ADC-163 ADC-164 is a ADC beta-lactamase. ADC-164 antibiotic_resistance ARO:3006336 ADC-164 ARO:3006336 ADC-164 ADC-165 is a ADC beta-lactamase. ADC-165 antibiotic_resistance ARO:3006337 ADC-165 ARO:3006337 ADC-165 ADC-166 is a ADC beta-lactamase. ADC-166 antibiotic_resistance ARO:3006338 ADC-166 ARO:3006338 ADC-166 ADC-167 is a ADC beta-lactamase. ADC-167 antibiotic_resistance ARO:3006339 ADC-167 ARO:3006339 ADC-167 ADC-168 is a ADC beta-lactamase. ADC-168 antibiotic_resistance ARO:3006340 ADC-168 ARO:3006340 ADC-168 ADC-169 is a ADC beta-lactamase. ADC-169 antibiotic_resistance ARO:3006341 ADC-169 ARO:3006341 ADC-169 ADC-170 is a ADC beta-lactamase. ADC-170 antibiotic_resistance ARO:3006342 ADC-170 ARO:3006342 ADC-170 ADC-171 is a ADC beta-lactamase. ADC-171 antibiotic_resistance ARO:3006343 ADC-171 ARO:3006343 ADC-171 ADC-172 is a ADC beta-lactamase. ADC-172 antibiotic_resistance ARO:3006344 ADC-172 ARO:3006344 ADC-172 ADC-173 is a ADC beta-lactamase. ADC-173 antibiotic_resistance ARO:3006345 ADC-173 ARO:3006345 ADC-173 ADC-174 is a ADC beta-lactamase. ADC-174 antibiotic_resistance ARO:3006346 ADC-174 ARO:3006346 ADC-174 ADC-175 is a ADC beta-lactamase. ADC-175 antibiotic_resistance ARO:3006347 ADC-175 ARO:3006347 ADC-175 ADC-176 is a ADC beta-lactamase. ADC-176 antibiotic_resistance ARO:3006348 ADC-176 ARO:3006348 ADC-176 ADC-177 is a ADC beta-lactamase. ADC-177 antibiotic_resistance ARO:3006349 ADC-177 ARO:3006349 ADC-177 ADC-178 is a ADC beta-lactamase. ADC-178 antibiotic_resistance ARO:3006350 ADC-178 ARO:3006350 ADC-178 ADC-179 is a ADC beta-lactamase. ADC-179 antibiotic_resistance ARO:3006351 ADC-179 ARO:3006351 ADC-179 ADC-180 is a ADC beta-lactamase. ADC-180 antibiotic_resistance ARO:3006352 ADC-180 ARO:3006352 ADC-180 ADC-184 is a ADC beta-lactamase. ADC-184 antibiotic_resistance ARO:3006353 ADC-184 ARO:3006353 ADC-184 ADC-185 is a ADC beta-lactamase. ADC-185 antibiotic_resistance ARO:3006354 ADC-185 ARO:3006354 ADC-185 ADC-186 is a ADC beta-lactamase. ADC-186 antibiotic_resistance ARO:3006355 ADC-186 ARO:3006355 ADC-186 ADC-187 is a ADC beta-lactamase. ADC-187 antibiotic_resistance ARO:3006356 ADC-187 ARO:3006356 ADC-187 ADC-188 is a ADC beta-lactamase. ADC-188 antibiotic_resistance ARO:3006357 ADC-188 ARO:3006357 ADC-188 ADC-189 is a ADC beta-lactamase. ADC-189 antibiotic_resistance ARO:3006358 ADC-189 ARO:3006358 ADC-189 ADC-190 is a ADC beta-lactamase. ADC-190 antibiotic_resistance ARO:3006359 ADC-190 ARO:3006359 ADC-190 ADC-191 is a ADC beta-lactamase. ADC-191 antibiotic_resistance ARO:3006360 ADC-191 ARO:3006360 ADC-191 ADC-192 is a ADC beta-lactamase. ADC-192 antibiotic_resistance ARO:3006361 ADC-192 ARO:3006361 ADC-192 ADC-193 is a ADC beta-lactamase. ADC-193 antibiotic_resistance ARO:3006362 ADC-193 ARO:3006362 ADC-193 ADC-194 is a ADC beta-lactamase. ADC-194 antibiotic_resistance ARO:3006363 ADC-194 ARO:3006363 ADC-194 ADC-195 is a ADC beta-lactamase. ADC-195 antibiotic_resistance ARO:3006364 ADC-195 ARO:3006364 ADC-195 ADC-196 is a ADC beta-lactamase. ADC-196 antibiotic_resistance ARO:3006365 ADC-196 ARO:3006365 ADC-196 ADC-197 is a ADC beta-lactamase. ADC-197 antibiotic_resistance ARO:3006366 ADC-197 ARO:3006366 ADC-197 ADC-198 is a ADC beta-lactamase. ADC-198 antibiotic_resistance ARO:3006367 ADC-198 ARO:3006367 ADC-198 ADC-199 is a ADC beta-lactamase. ADC-199 antibiotic_resistance ARO:3006368 ADC-199 ARO:3006368 ADC-199 ADC-200 is a ADC beta-lactamase. ADC-200 antibiotic_resistance ARO:3006369 ADC-200 ARO:3006369 ADC-200 ADC-201 is a ADC beta-lactamase. ADC-201 antibiotic_resistance ARO:3006370 ADC-201 ARO:3006370 ADC-201 ADC-202 is a ADC beta-lactamase. ADC-202 antibiotic_resistance ARO:3006371 ADC-202 ARO:3006371 ADC-202 ADC-203 is a ADC beta-lactamase. ADC-203 antibiotic_resistance ARO:3006372 ADC-203 ARO:3006372 ADC-203 ADC-204 is a ADC beta-lactamase. ADC-204 antibiotic_resistance ARO:3006373 ADC-204 ARO:3006373 ADC-204 ADC-205 is a ADC beta-lactamase. ADC-205 antibiotic_resistance ARO:3006374 ADC-205 ARO:3006374 ADC-205 ADC-206 is a ADC beta-lactamase. ADC-206 antibiotic_resistance ARO:3006375 ADC-206 ARO:3006375 ADC-206 ADC-207 is a ADC beta-lactamase. ADC-207 antibiotic_resistance ARO:3006376 ADC-207 ARO:3006376 ADC-207 ADC-208 is a ADC beta-lactamase. ADC-208 antibiotic_resistance ARO:3006377 ADC-208 ARO:3006377 ADC-208 ADC-209 is a ADC beta-lactamase. ADC-209 antibiotic_resistance ARO:3006378 ADC-209 ARO:3006378 ADC-209 ADC-210 is a ADC beta-lactamase. ADC-210 antibiotic_resistance ARO:3006379 ADC-210 ARO:3006379 ADC-210 ADC-211 is a ADC beta-lactamase. ADC-211 antibiotic_resistance ARO:3006380 ADC-211 ARO:3006380 ADC-211 ADC-212 is a ADC beta-lactamase. ADC-212 antibiotic_resistance ARO:3006381 ADC-212 ARO:3006381 ADC-212 ADC-213 is a ADC beta-lactamase. ADC-213 antibiotic_resistance ARO:3006382 ADC-213 ARO:3006382 ADC-213 ADC-214 is a ADC beta-lactamase. ADC-214 antibiotic_resistance ARO:3006383 ADC-214 ARO:3006383 ADC-214 ADC-215 is a ADC beta-lactamase. ADC-215 antibiotic_resistance ARO:3006384 ADC-215 ARO:3006384 ADC-215 ADC-216 is a ADC beta-lactamase. ADC-216 antibiotic_resistance ARO:3006385 ADC-216 ARO:3006385 ADC-216 ADC-217 is a ADC beta-lactamase. ADC-217 antibiotic_resistance ARO:3006386 ADC-217 ARO:3006386 ADC-217 ADC-218 is a ADC beta-lactamase. ADC-218 antibiotic_resistance ARO:3006387 ADC-218 ARO:3006387 ADC-218 ADC-219 is a ADC beta-lactamase. ADC-219 antibiotic_resistance ARO:3006388 ADC-219 ARO:3006388 ADC-219 ADC-220 is a ADC beta-lactamase. ADC-220 antibiotic_resistance ARO:3006389 ADC-220 ARO:3006389 ADC-220 ADC-221 is a ADC beta-lactamase. ADC-221 antibiotic_resistance ARO:3006390 ADC-221 ARO:3006390 ADC-221 ADC-222 is a ADC beta-lactamase. ADC-222 antibiotic_resistance ARO:3006391 ADC-222 ARO:3006391 ADC-222 ADC-223 is a ADC beta-lactamase. ADC-223 antibiotic_resistance ARO:3006392 ADC-223 ARO:3006392 ADC-223 ADC-224 is a ADC beta-lactamase. ADC-224 antibiotic_resistance ARO:3006393 ADC-224 ARO:3006393 ADC-224 ADC-225 is a ADC beta-lactamase. ADC-225 antibiotic_resistance ARO:3006394 ADC-225 ARO:3006394 ADC-225 ADC-226 is a ADC beta-lactamase. ADC-226 antibiotic_resistance ARO:3006395 ADC-226 ARO:3006395 ADC-226 ADC-227 is a ADC beta-lactamase. ADC-227 antibiotic_resistance ARO:3006396 ADC-227 ARO:3006396 ADC-227 ADC-228 is a ADC beta-lactamase. ADC-228 antibiotic_resistance ARO:3006397 ADC-228 ARO:3006397 ADC-228 ADC-229 is a ADC beta-lactamase. ADC-229 antibiotic_resistance ARO:3006398 ADC-229 ARO:3006398 ADC-229 ADC-230 is a ADC beta-lactamase. ADC-230 antibiotic_resistance ARO:3006399 ADC-230 ARO:3006399 ADC-230 ADC-231 is a ADC beta-lactamase. ADC-231 antibiotic_resistance ARO:3006400 ADC-231 ARO:3006400 ADC-231 ADC-232 is a ADC beta-lactamase. ADC-232 antibiotic_resistance ARO:3006401 ADC-232 ARO:3006401 ADC-232 ADC-233 is a ADC beta-lactamase. ADC-233 antibiotic_resistance ARO:3006402 ADC-233 ARO:3006402 ADC-233 ADC-234 is a ADC beta-lactamase. ADC-234 antibiotic_resistance ARO:3006403 ADC-234 ARO:3006403 ADC-234 ADC-235 is a ADC beta-lactamase. ADC-235 antibiotic_resistance ARO:3006404 ADC-235 ARO:3006404 ADC-235 ADC-236 is a ADC beta-lactamase. ADC-236 antibiotic_resistance ARO:3006405 ADC-236 ARO:3006405 ADC-236 ADC-237 is a ADC beta-lactamase. ADC-237 antibiotic_resistance ARO:3006406 ADC-237 ARO:3006406 ADC-237 ADC-238 is a ADC beta-lactamase. ADC-238 antibiotic_resistance ARO:3006407 ADC-238 ARO:3006407 ADC-238 ADC-239 is a ADC beta-lactamase. ADC-239 antibiotic_resistance ARO:3006408 ADC-239 ARO:3006408 ADC-239 ADC-24 is a ADC beta-lactamase. ADC-24 antibiotic_resistance ARO:3006409 ADC-24 ARO:3006409 ADC-24 ADC-240 is a ADC beta-lactamase. ADC-240 antibiotic_resistance ARO:3006410 ADC-240 ARO:3006410 ADC-240 ADC-241 is a ADC beta-lactamase. ADC-241 antibiotic_resistance ARO:3006411 ADC-241 ARO:3006411 ADC-241 ADC-242 is a ADC beta-lactamase. ADC-242 antibiotic_resistance ARO:3006412 ADC-242 ARO:3006412 ADC-242 ADC-243 is a ADC beta-lactamase. ADC-243 antibiotic_resistance ARO:3006413 ADC-243 ARO:3006413 ADC-243 ADC-244 is a ADC beta-lactamase. ADC-244 antibiotic_resistance ARO:3006414 ADC-244 ARO:3006414 ADC-244 ADC-245 is a ADC beta-lactamase. ADC-245 antibiotic_resistance ARO:3006415 ADC-245 ARO:3006415 ADC-245 ADC-246 is a ADC beta-lactamase. ADC-246 antibiotic_resistance ARO:3006416 ADC-246 ARO:3006416 ADC-246 ADC-247 is a ADC beta-lactamase. ADC-247 antibiotic_resistance ARO:3006417 ADC-247 ARO:3006417 ADC-247 ADC-248 is a ADC beta-lactamase. ADC-248 antibiotic_resistance ARO:3006418 ADC-248 ARO:3006418 ADC-248 ADC-249 is a ADC beta-lactamase. ADC-249 antibiotic_resistance ARO:3006419 ADC-249 ARO:3006419 ADC-249 ADC-250 is a ADC beta-lactamase. ADC-250 antibiotic_resistance ARO:3006420 ADC-250 ARO:3006420 ADC-250 ADC-251 is a ADC beta-lactamase. ADC-251 antibiotic_resistance ARO:3006421 ADC-251 ARO:3006421 ADC-251 ADC-252 is a ADC beta-lactamase. ADC-252 antibiotic_resistance ARO:3006422 ADC-252 ARO:3006422 ADC-252 ADC-253 is a ADC beta-lactamase. ADC-253 antibiotic_resistance ARO:3006423 ADC-253 ARO:3006423 ADC-253 ADC-254 is a ADC beta-lactamase. ADC-254 antibiotic_resistance ARO:3006424 ADC-254 ARO:3006424 ADC-254 ADC-255 is a ADC beta-lactamase. ADC-255 antibiotic_resistance ARO:3006425 ADC-255 ARO:3006425 ADC-255 ADC-256 is a ADC beta-lactamase. ADC-256 antibiotic_resistance ARO:3006426 ADC-256 ARO:3006426 ADC-256 ADC-29 is a ADC beta-lactamase. ADC-29 antibiotic_resistance ARO:3006427 ADC-29 ARO:3006427 ADC-29 ADC-32 is a ADC beta-lactamase. ADC-32 antibiotic_resistance ARO:3006428 ADC-32 ARO:3006428 ADC-32 ADC-33 is a ADC beta-lactamase. ADC-33 antibiotic_resistance ARO:3006429 ADC-33 ARO:3006429 ADC-33 ADC-38 is a ADC beta-lactamase. ADC-38 antibiotic_resistance ARO:3006430 ADC-38 ARO:3006430 ADC-38 ADC-51 is a ADC beta-lactamase. ADC-51 antibiotic_resistance ARO:3006431 ADC-51 ARO:3006431 ADC-51 ADC-52 is a ADC beta-lactamase. ADC-52 antibiotic_resistance ARO:3006432 ADC-52 ARO:3006432 ADC-52 ADC-53 is a ADC beta-lactamase. ADC-53 antibiotic_resistance ARO:3006433 ADC-53 ARO:3006433 ADC-53 ADC-54 is a ADC beta-lactamase. ADC-54 antibiotic_resistance ARO:3006434 ADC-54 ARO:3006434 ADC-54 ADC-57 is a ADC beta-lactamase. ADC-57 antibiotic_resistance ARO:3006435 ADC-57 ARO:3006435 ADC-57 ADC-63 is a ADC beta-lactamase. ADC-63 antibiotic_resistance ARO:3006436 ADC-63 ARO:3006436 ADC-63 ADC-65 is a ADC beta-lactamase. ADC-65 antibiotic_resistance ARO:3006437 ADC-65 ARO:3006437 ADC-65 ADC-66 is a ADC beta-lactamase. ADC-66 antibiotic_resistance ARO:3006438 ADC-66 ARO:3006438 ADC-66 ADC-70 is a ADC beta-lactamase. ADC-70 antibiotic_resistance ARO:3006439 ADC-70 ARO:3006439 ADC-70 ADC-83 is a ADC beta-lactamase. ADC-83 antibiotic_resistance ARO:3006440 ADC-83 ARO:3006440 ADC-83 ADC-84 is a ADC beta-lactamase. ADC-84 antibiotic_resistance ARO:3006441 ADC-84 ARO:3006441 ADC-84 ADC-85 is a ADC beta-lactamase. ADC-85 antibiotic_resistance ARO:3006442 ADC-85 ARO:3006442 ADC-85 ADC-86 is a ADC beta-lactamase. ADC-86 antibiotic_resistance ARO:3006443 ADC-86 ARO:3006443 ADC-86 ADC-87 is a ADC beta-lactamase. ADC-87 antibiotic_resistance ARO:3006444 ADC-87 ARO:3006444 ADC-87 ADC-88 is a ADC beta-lactamase. ADC-88 antibiotic_resistance ARO:3006445 ADC-88 ARO:3006445 ADC-88 ADC-89 is a ADC beta-lactamase. ADC-89 antibiotic_resistance ARO:3006446 ADC-89 ARO:3006446 ADC-89 ADC-90 is a ADC beta-lactamase. ADC-90 antibiotic_resistance ARO:3006447 ADC-90 ARO:3006447 ADC-90 ADC-91 is a ADC beta-lactamase. ADC-91 antibiotic_resistance ARO:3006448 ADC-91 ARO:3006448 ADC-91 ADC-92 is a ADC beta-lactamase. ADC-92 antibiotic_resistance ARO:3006449 ADC-92 ARO:3006449 ADC-92 ADC-93 is a ADC beta-lactamase. ADC-93 antibiotic_resistance ARO:3006450 ADC-93 ARO:3006450 ADC-93 ADC-94 is a ADC beta-lactamase. ADC-94 antibiotic_resistance ARO:3006451 ADC-94 ARO:3006451 ADC-94 ADC-95 is a ADC beta-lactamase. ADC-95 antibiotic_resistance ARO:3006452 ADC-95 ARO:3006452 ADC-95 ADC-96 is a ADC beta-lactamase. ADC-96 antibiotic_resistance ARO:3006453 ADC-96 ARO:3006453 ADC-96 ADC-97 is a ADC beta-lactamase. ADC-97 antibiotic_resistance ARO:3006454 ADC-97 ARO:3006454 ADC-97 ADC-98 is a ADC beta-lactamase. ADC-98 antibiotic_resistance ARO:3006455 ADC-98 ARO:3006455 ADC-98 ADC-99 is a ADC beta-lactamase. ADC-99 antibiotic_resistance ARO:3006456 ADC-99 ARO:3006456 ADC-99 CMY-137 is a CMY beta-lactamase. CMY-137 antibiotic_resistance ARO:3006457 CMY-137 ARO:3006457 CMY-137 CMY-159 is a CMY beta-lactamase. CMY-159 antibiotic_resistance ARO:3006458 CMY-159 ARO:3006458 CMY-159 CMY-167 is a CMY beta-lactamase. CMY-167 antibiotic_resistance ARO:3006459 CMY-167 ARO:3006459 CMY-167 CMY-168 is a CMY beta-lactamase. CMY-168 antibiotic_resistance ARO:3006460 CMY-168 ARO:3006460 CMY-168 CMY-169 is a CMY beta-lactamase. CMY-169 antibiotic_resistance ARO:3006461 CMY-169 ARO:3006461 CMY-169 CMY-170 is a CMY beta-lactamase. CMY-170 antibiotic_resistance ARO:3006462 CMY-170 ARO:3006462 CMY-170 CMY-174 is a CMY beta-lactamase. CMY-174 antibiotic_resistance ARO:3006463 CMY-174 ARO:3006463 CMY-174 CMY-8b is a CMY beta-lactamase. CMY-8b antibiotic_resistance ARO:3006464 CMY-8b ARO:3006464 CMY-8b DHA-24 is a DHA beta-lactamase. DHA-24 antibiotic_resistance ARO:3006465 DHA-24 ARO:3006465 DHA-24 DHA-25 is a DHA beta-lactamase. DHA-25 antibiotic_resistance ARO:3006466 DHA-25 ARO:3006466 DHA-25 DHA-26 is a DHA beta-lactamase. DHA-26 antibiotic_resistance ARO:3006467 DHA-26 ARO:3006467 DHA-26 DHA-27 is a DHA beta-lactamase. DHA-27 antibiotic_resistance ARO:3006468 DHA-27 ARO:3006468 DHA-27 DHA-28 is a DHA beta-lactamase. DHA-28 antibiotic_resistance ARO:3006469 DHA-28 ARO:3006469 DHA-28 DHA-29 is a DHA beta-lactamase. DHA-29 antibiotic_resistance ARO:3006470 DHA-29 ARO:3006470 DHA-29 FOX-13 is a FOX beta-lactamase. FOX-13 antibiotic_resistance ARO:3006471 FOX-13 ARO:3006471 FOX-13 FOX-14 is a FOX beta-lactamase. FOX-14 antibiotic_resistance ARO:3006472 FOX-14 ARO:3006472 FOX-14 FOX-15 is a FOX beta-lactamase. FOX-15 antibiotic_resistance ARO:3006473 FOX-15 ARO:3006473 FOX-15 FOX-16 is a FOX beta-lactamase. FOX-16 antibiotic_resistance ARO:3006474 FOX-16 ARO:3006474 FOX-16 FOX-17 is a FOX beta-lactamase. FOX-17 antibiotic_resistance ARO:3006475 FOX-17 ARO:3006475 FOX-17 MOX-12 is a MOX beta-lactamase. MOX-12 antibiotic_resistance ARO:3006477 MOX-12 ARO:3006477 MOX-12 MOX-13 is a MOX beta-lactamase. MOX-13 antibiotic_resistance ARO:3006478 MOX-13 ARO:3006478 MOX-13 MOX-14 is a MOX beta-lactamase. MOX-14 antibiotic_resistance ARO:3006479 MOX-14 ARO:3006479 MOX-14 PDC-100 is a PDC beta-lactamase. PDC-100 antibiotic_resistance ARO:3006480 PDC-100 ARO:3006480 PDC-100 PDC-101 is a PDC beta-lactamase. PDC-101 antibiotic_resistance ARO:3006481 PDC-101 ARO:3006481 PDC-101 PDC-102 is a PDC beta-lactamase. PDC-102 antibiotic_resistance ARO:3006482 PDC-102 ARO:3006482 PDC-102 PDC-103 is a PDC beta-lactamase. PDC-103 antibiotic_resistance ARO:3006483 PDC-103 ARO:3006483 PDC-103 PDC-106 is a PDC beta-lactamase. PDC-106 antibiotic_resistance ARO:3006484 PDC-106 ARO:3006484 PDC-106 PDC-107 is a PDC beta-lactamase. PDC-107 antibiotic_resistance ARO:3006485 PDC-107 ARO:3006485 PDC-107 PDC-108 is a PDC beta-lactamase. PDC-108 antibiotic_resistance ARO:3006486 PDC-108 ARO:3006486 PDC-108 PDC-109 is a PDC beta-lactamase. PDC-109 antibiotic_resistance ARO:3006487 PDC-109 ARO:3006487 PDC-109 PDC-110 is a PDC beta-lactamase. PDC-110 antibiotic_resistance ARO:3006488 PDC-110 ARO:3006488 PDC-110 PDC-111 is a PDC beta-lactamase. PDC-111 antibiotic_resistance ARO:3006489 PDC-111 ARO:3006489 PDC-111 PDC-112 is a PDC beta-lactamase. PDC-112 antibiotic_resistance ARO:3006490 PDC-112 ARO:3006490 PDC-112 PDC-113 is a PDC beta-lactamase. PDC-113 antibiotic_resistance ARO:3006491 PDC-113 ARO:3006491 PDC-113 PDC-114 is a PDC beta-lactamase. PDC-114 antibiotic_resistance ARO:3006492 PDC-114 ARO:3006492 PDC-114 PDC-115 is a PDC beta-lactamase. PDC-115 antibiotic_resistance ARO:3006493 PDC-115 ARO:3006493 PDC-115 PDC-116 is a PDC beta-lactamase. PDC-116 antibiotic_resistance ARO:3006494 PDC-116 ARO:3006494 PDC-116 PDC-12 is a PDC beta-lactamase. PDC-12 antibiotic_resistance ARO:3006495 PDC-12 ARO:3006495 PDC-12 PDC-120 is a PDC beta-lactamase. PDC-120 antibiotic_resistance ARO:3006496 PDC-120 ARO:3006496 PDC-120 PDC-121 is a PDC beta-lactamase. PDC-121 antibiotic_resistance ARO:3006497 PDC-121 ARO:3006497 PDC-121 PDC-122 is a PDC beta-lactamase. PDC-122 antibiotic_resistance ARO:3006498 PDC-122 ARO:3006498 PDC-122 PDC-123 is a PDC beta-lactamase. PDC-123 antibiotic_resistance ARO:3006499 PDC-123 ARO:3006499 PDC-123 PDC-124 is a PDC beta-lactamase. PDC-124 antibiotic_resistance ARO:3006500 PDC-124 ARO:3006500 PDC-124 PDC-125 is a PDC beta-lactamase. PDC-125 antibiotic_resistance ARO:3006501 PDC-125 ARO:3006501 PDC-125 PDC-126 is a PDC beta-lactamase. PDC-126 antibiotic_resistance ARO:3006502 PDC-126 ARO:3006502 PDC-126 PDC-127 is a PDC beta-lactamase. PDC-127 antibiotic_resistance ARO:3006503 PDC-127 ARO:3006503 PDC-127 PDC-128 is a PDC beta-lactamase. PDC-128 antibiotic_resistance ARO:3006504 PDC-128 ARO:3006504 PDC-128 PDC-129 is a PDC beta-lactamase. PDC-129 antibiotic_resistance ARO:3006505 PDC-129 ARO:3006505 PDC-129 PDC-13 is a PDC beta-lactamase. PDC-13 antibiotic_resistance ARO:3006506 PDC-13 ARO:3006506 PDC-13 PDC-130 is a PDC beta-lactamase. PDC-130 antibiotic_resistance ARO:3006507 PDC-130 ARO:3006507 PDC-130 PDC-131 is a PDC beta-lactamase. PDC-131 antibiotic_resistance ARO:3006508 PDC-131 ARO:3006508 PDC-131 PDC-132 is a PDC beta-lactamase. PDC-132 antibiotic_resistance ARO:3006509 PDC-132 ARO:3006509 PDC-132 PDC-133 is a PDC beta-lactamase. PDC-133 antibiotic_resistance ARO:3006510 PDC-133 ARO:3006510 PDC-133 PDC-134 is a PDC beta-lactamase. PDC-134 antibiotic_resistance ARO:3006511 PDC-134 ARO:3006511 PDC-134 PDC-135 is a PDC beta-lactamase. PDC-135 antibiotic_resistance ARO:3006512 PDC-135 ARO:3006512 PDC-135 PDC-136 is a PDC beta-lactamase. PDC-136 antibiotic_resistance ARO:3006513 PDC-136 ARO:3006513 PDC-136 PDC-137 is a PDC beta-lactamase. PDC-137 antibiotic_resistance ARO:3006514 PDC-137 ARO:3006514 PDC-137 PDC-138 is a PDC beta-lactamase. PDC-138 antibiotic_resistance ARO:3006515 PDC-138 ARO:3006515 PDC-138 PDC-139 is a PDC beta-lactamase. PDC-139 antibiotic_resistance ARO:3006516 PDC-139 ARO:3006516 PDC-139 PDC-140 is a PDC beta-lactamase. PDC-140 antibiotic_resistance ARO:3006517 PDC-140 ARO:3006517 PDC-140 PDC-141 is a PDC beta-lactamase. PDC-141 antibiotic_resistance ARO:3006518 PDC-141 ARO:3006518 PDC-141 PDC-142 is a PDC beta-lactamase. PDC-142 antibiotic_resistance ARO:3006519 PDC-142 ARO:3006519 PDC-142 PDC-143 is a PDC beta-lactamase. PDC-143 antibiotic_resistance ARO:3006520 PDC-143 ARO:3006520 PDC-143 PDC-144 is a PDC beta-lactamase. PDC-144 antibiotic_resistance ARO:3006521 PDC-144 ARO:3006521 PDC-144 PDC-145 is a PDC beta-lactamase. PDC-145 antibiotic_resistance ARO:3006522 PDC-145 ARO:3006522 PDC-145 PDC-146 is a PDC beta-lactamase. PDC-146 antibiotic_resistance ARO:3006523 PDC-146 ARO:3006523 PDC-146 PDC-147 is a PDC beta-lactamase. PDC-147 antibiotic_resistance ARO:3006524 PDC-147 ARO:3006524 PDC-147 PDC-148 is a PDC beta-lactamase. PDC-148 antibiotic_resistance ARO:3006525 PDC-148 ARO:3006525 PDC-148 PDC-149 is a PDC beta-lactamase. PDC-149 antibiotic_resistance ARO:3006526 PDC-149 ARO:3006526 PDC-149 PDC-15 is a PDC beta-lactamase. PDC-15 antibiotic_resistance ARO:3006527 PDC-15 ARO:3006527 PDC-15 PDC-150 is a PDC beta-lactamase. PDC-150 antibiotic_resistance ARO:3006528 PDC-150 ARO:3006528 PDC-150 PDC-151 is a PDC beta-lactamase. PDC-151 antibiotic_resistance ARO:3006529 PDC-151 ARO:3006529 PDC-151 PDC-152 is a PDC beta-lactamase. PDC-152 antibiotic_resistance ARO:3006530 PDC-152 ARO:3006530 PDC-152 PDC-153 is a PDC beta-lactamase. PDC-153 antibiotic_resistance ARO:3006531 PDC-153 ARO:3006531 PDC-153 PDC-154 is a PDC beta-lactamase. PDC-154 antibiotic_resistance ARO:3006532 PDC-154 ARO:3006532 PDC-154 PDC-155 is a PDC beta-lactamase. PDC-155 antibiotic_resistance ARO:3006533 PDC-155 ARO:3006533 PDC-155 PDC-156 is a PDC beta-lactamase. PDC-156 antibiotic_resistance ARO:3006534 PDC-156 ARO:3006534 PDC-156 PDC-157 is a PDC beta-lactamase. PDC-157 antibiotic_resistance ARO:3006535 PDC-157 ARO:3006535 PDC-157 PDC-158 is a PDC beta-lactamase. PDC-158 antibiotic_resistance ARO:3006536 PDC-158 ARO:3006536 PDC-158 PDC-159 is a PDC beta-lactamase. PDC-159 antibiotic_resistance ARO:3006537 PDC-159 ARO:3006537 PDC-159 PDC-16 is a PDC beta-lactamase. PDC-16 antibiotic_resistance ARO:3006538 PDC-16 ARO:3006538 PDC-16 PDC-160 is a PDC beta-lactamase. PDC-160 antibiotic_resistance ARO:3006539 PDC-160 ARO:3006539 PDC-160 PDC-161 is a PDC beta-lactamase. PDC-161 antibiotic_resistance ARO:3006540 PDC-161 ARO:3006540 PDC-161 PDC-162 is a PDC beta-lactamase. PDC-162 antibiotic_resistance ARO:3006541 PDC-162 ARO:3006541 PDC-162 PDC-163 is a PDC beta-lactamase. PDC-163 antibiotic_resistance ARO:3006542 PDC-163 ARO:3006542 PDC-163 PDC-164 is a PDC beta-lactamase. PDC-164 antibiotic_resistance ARO:3006543 PDC-164 ARO:3006543 PDC-164 PDC-165 is a PDC beta-lactamase. PDC-165 antibiotic_resistance ARO:3006544 PDC-165 ARO:3006544 PDC-165 PDC-166 is a PDC beta-lactamase. PDC-166 antibiotic_resistance ARO:3006545 PDC-166 ARO:3006545 PDC-166 PDC-167 is a PDC beta-lactamase. PDC-167 antibiotic_resistance ARO:3006546 PDC-167 ARO:3006546 PDC-167 PDC-168 is a PDC beta-lactamase. PDC-168 antibiotic_resistance ARO:3006547 PDC-168 ARO:3006547 PDC-168 PDC-169 is a PDC beta-lactamase. PDC-169 antibiotic_resistance ARO:3006548 PDC-169 ARO:3006548 PDC-169 PDC-17 is a PDC beta-lactamase. PDC-17 antibiotic_resistance ARO:3006549 PDC-17 ARO:3006549 PDC-17 PDC-170 is a PDC beta-lactamase. PDC-170 antibiotic_resistance ARO:3006550 PDC-170 ARO:3006550 PDC-170 PDC-171 is a PDC beta-lactamase. PDC-171 antibiotic_resistance ARO:3006551 PDC-171 ARO:3006551 PDC-171 PDC-172 is a PDC beta-lactamase. PDC-172 antibiotic_resistance ARO:3006552 PDC-172 ARO:3006552 PDC-172 PDC-174 is a PDC beta-lactamase. PDC-174 antibiotic_resistance ARO:3006553 PDC-174 ARO:3006553 PDC-174 PDC-175 is a PDC beta-lactamase. PDC-175 antibiotic_resistance ARO:3006554 PDC-175 ARO:3006554 PDC-175 PDC-176 is a PDC beta-lactamase. PDC-176 antibiotic_resistance ARO:3006555 PDC-176 ARO:3006555 PDC-176 PDC-177 is a PDC beta-lactamase. PDC-177 antibiotic_resistance ARO:3006556 PDC-177 ARO:3006556 PDC-177 PDC-178 is a PDC beta-lactamase. PDC-178 antibiotic_resistance ARO:3006557 PDC-178 ARO:3006557 PDC-178 PDC-179 is a PDC beta-lactamase. PDC-179 antibiotic_resistance ARO:3006558 PDC-179 ARO:3006558 PDC-179 PDC-18 is a PDC beta-lactamase. PDC-18 antibiotic_resistance ARO:3006559 PDC-18 ARO:3006559 PDC-18 PDC-180 is a PDC beta-lactamase. PDC-180 antibiotic_resistance ARO:3006560 PDC-180 ARO:3006560 PDC-180 PDC-181 is a PDC beta-lactamase. PDC-181 antibiotic_resistance ARO:3006561 PDC-181 ARO:3006561 PDC-181 PDC-182 is a PDC beta-lactamase. PDC-182 antibiotic_resistance ARO:3006562 PDC-182 ARO:3006562 PDC-182 PDC-184 is a PDC beta-lactamase. PDC-184 antibiotic_resistance ARO:3006563 PDC-184 ARO:3006563 PDC-184 PDC-185 is a PDC beta-lactamase. PDC-185 antibiotic_resistance ARO:3006564 PDC-185 ARO:3006564 PDC-185 PDC-186 is a PDC beta-lactamase. PDC-186 antibiotic_resistance ARO:3006565 PDC-186 ARO:3006565 PDC-186 PDC-187 is a PDC beta-lactamase. PDC-187 antibiotic_resistance ARO:3006566 PDC-187 ARO:3006566 PDC-187 PDC-188 is a PDC beta-lactamase. PDC-188 antibiotic_resistance ARO:3006567 PDC-188 ARO:3006567 PDC-188 PDC-189 is a PDC beta-lactamase. PDC-189 antibiotic_resistance ARO:3006568 PDC-189 ARO:3006568 PDC-189 PDC-190 is a PDC beta-lactamase. PDC-190 antibiotic_resistance ARO:3006569 PDC-190 ARO:3006569 PDC-190 PDC-191 is a PDC beta-lactamase. PDC-191 antibiotic_resistance ARO:3006570 PDC-191 ARO:3006570 PDC-191 PDC-192 is a PDC beta-lactamase. PDC-192 antibiotic_resistance ARO:3006571 PDC-192 ARO:3006571 PDC-192 PDC-193 is a PDC beta-lactamase. PDC-193 antibiotic_resistance ARO:3006572 PDC-193 ARO:3006572 PDC-193 PDC-194 is a PDC beta-lactamase. PDC-194 antibiotic_resistance ARO:3006573 PDC-194 ARO:3006573 PDC-194 PDC-195 is a PDC beta-lactamase. PDC-195 antibiotic_resistance ARO:3006574 PDC-195 ARO:3006574 PDC-195 PDC-196 is a PDC beta-lactamase. PDC-196 antibiotic_resistance ARO:3006575 PDC-196 ARO:3006575 PDC-196 PDC-197 is a PDC beta-lactamase. PDC-197 antibiotic_resistance ARO:3006576 PDC-197 ARO:3006576 PDC-197 PDC-198 is a PDC beta-lactamase. PDC-198 antibiotic_resistance ARO:3006577 PDC-198 ARO:3006577 PDC-198 PDC-199 is a PDC beta-lactamase. PDC-199 antibiotic_resistance ARO:3006578 PDC-199 ARO:3006578 PDC-199 PDC-20 is a PDC beta-lactamase. PDC-20 antibiotic_resistance ARO:3006579 PDC-20 ARO:3006579 PDC-20 PDC-200 is a PDC beta-lactamase. PDC-200 antibiotic_resistance ARO:3006580 PDC-200 ARO:3006580 PDC-200 PDC-202 is a PDC beta-lactamase. PDC-202 antibiotic_resistance ARO:3006581 PDC-202 ARO:3006581 PDC-202 PDC-203 is a PDC beta-lactamase. PDC-203 antibiotic_resistance ARO:3006582 PDC-203 ARO:3006582 PDC-203 PDC-204 is a PDC beta-lactamase. PDC-204 antibiotic_resistance ARO:3006583 PDC-204 ARO:3006583 PDC-204 PDC-205 is a PDC beta-lactamase. PDC-205 antibiotic_resistance ARO:3006584 PDC-205 ARO:3006584 PDC-205 PDC-206 is a PDC beta-lactamase. PDC-206 antibiotic_resistance ARO:3006585 PDC-206 ARO:3006585 PDC-206 PDC-208 is a PDC beta-lactamase. PDC-208 antibiotic_resistance ARO:3006586 PDC-208 ARO:3006586 PDC-208 PDC-209 is a PDC beta-lactamase. PDC-209 antibiotic_resistance ARO:3006587 PDC-209 ARO:3006587 PDC-209 PDC-210 is a PDC beta-lactamase. PDC-210 antibiotic_resistance ARO:3006588 PDC-210 ARO:3006588 PDC-210 PDC-211 is a PDC beta-lactamase. PDC-211 antibiotic_resistance ARO:3006589 PDC-211 ARO:3006589 PDC-211 PDC-213 is a PDC beta-lactamase. PDC-213 antibiotic_resistance ARO:3006590 PDC-213 ARO:3006590 PDC-213 PDC-214 is a PDC beta-lactamase. PDC-214 antibiotic_resistance ARO:3006591 PDC-214 ARO:3006591 PDC-214 PDC-215 is a PDC beta-lactamase. PDC-215 antibiotic_resistance ARO:3006592 PDC-215 ARO:3006592 PDC-215 PDC-216 is a PDC beta-lactamase. PDC-216 antibiotic_resistance ARO:3006593 PDC-216 ARO:3006593 PDC-216 PDC-217 is a PDC beta-lactamase. PDC-217 antibiotic_resistance ARO:3006594 PDC-217 ARO:3006594 PDC-217 PDC-218 is a PDC beta-lactamase. PDC-218 antibiotic_resistance ARO:3006595 PDC-218 ARO:3006595 PDC-218 PDC-219 is a PDC beta-lactamase. PDC-219 antibiotic_resistance ARO:3006596 PDC-219 ARO:3006596 PDC-219 PDC-21a is a PDC beta-lactamase. PDC-21a antibiotic_resistance ARO:3006597 PDC-21a ARO:3006597 PDC-21a PDC-21b is a PDC beta-lactamase. PDC-21b antibiotic_resistance ARO:3006598 PDC-21b ARO:3006598 PDC-21b PDC-22 is a PDC beta-lactamase. PDC-22 antibiotic_resistance ARO:3006599 PDC-22 ARO:3006599 PDC-22 PDC-220 is a PDC beta-lactamase. PDC-220 antibiotic_resistance ARO:3006600 PDC-220 ARO:3006600 PDC-220 PDC-221 is a PDC beta-lactamase. PDC-221 antibiotic_resistance ARO:3006601 PDC-221 ARO:3006601 PDC-221 PDC-222 is a PDC beta-lactamase. PDC-222 antibiotic_resistance ARO:3006602 PDC-222 ARO:3006602 PDC-222 PDC-223 is a PDC beta-lactamase. PDC-223 antibiotic_resistance ARO:3006603 PDC-223 ARO:3006603 PDC-223 PDC-224 is a PDC beta-lactamase. PDC-224 antibiotic_resistance ARO:3006604 PDC-224 ARO:3006604 PDC-224 PDC-226 is a PDC beta-lactamase. PDC-226 antibiotic_resistance ARO:3006605 PDC-226 ARO:3006605 PDC-226 PDC-227 is a PDC beta-lactamase. PDC-227 antibiotic_resistance ARO:3006606 PDC-227 ARO:3006606 PDC-227 PDC-228 is a PDC beta-lactamase. PDC-228 antibiotic_resistance ARO:3006607 PDC-228 ARO:3006607 PDC-228 PDC-229 is a PDC beta-lactamase. PDC-229 antibiotic_resistance ARO:3006608 PDC-229 ARO:3006608 PDC-229 PDC-230 is a PDC beta-lactamase. PDC-230 antibiotic_resistance ARO:3006609 PDC-230 ARO:3006609 PDC-230 PDC-232 is a PDC beta-lactamase. PDC-232 antibiotic_resistance ARO:3006610 PDC-232 ARO:3006610 PDC-232 PDC-233 is a PDC beta-lactamase. PDC-233 antibiotic_resistance ARO:3006611 PDC-233 ARO:3006611 PDC-233 PDC-234 is a PDC beta-lactamase. PDC-234 antibiotic_resistance ARO:3006612 PDC-234 ARO:3006612 PDC-234 PDC-235 is a PDC beta-lactamase. PDC-235 antibiotic_resistance ARO:3006613 PDC-235 ARO:3006613 PDC-235 PDC-236 is a PDC beta-lactamase. PDC-236 antibiotic_resistance ARO:3006614 PDC-236 ARO:3006614 PDC-236 PDC-237 is a PDC beta-lactamase. PDC-237 antibiotic_resistance ARO:3006615 PDC-237 ARO:3006615 PDC-237 PDC-238 is a PDC beta-lactamase. PDC-238 antibiotic_resistance ARO:3006616 PDC-238 ARO:3006616 PDC-238 PDC-239 is a PDC beta-lactamase. PDC-239 antibiotic_resistance ARO:3006617 PDC-239 ARO:3006617 PDC-239 PDC-24 is a PDC beta-lactamase. PDC-24 antibiotic_resistance ARO:3006618 PDC-24 ARO:3006618 PDC-24 PDC-241 is a PDC beta-lactamase. PDC-241 antibiotic_resistance ARO:3006619 PDC-241 ARO:3006619 PDC-241 PDC-242 is a PDC beta-lactamase. PDC-242 antibiotic_resistance ARO:3006620 PDC-242 ARO:3006620 PDC-242 PDC-243 is a PDC beta-lactamase. PDC-243 antibiotic_resistance ARO:3006621 PDC-243 ARO:3006621 PDC-243 PDC-244 is a PDC beta-lactamase. PDC-244 antibiotic_resistance ARO:3006622 PDC-244 ARO:3006622 PDC-244 PDC-245 is a PDC beta-lactamase. PDC-245 antibiotic_resistance ARO:3006623 PDC-245 ARO:3006623 PDC-245 PDC-246 is a PDC beta-lactamase. PDC-246 antibiotic_resistance ARO:3006624 PDC-246 ARO:3006624 PDC-246 PDC-247 is a PDC beta-lactamase. PDC-247 antibiotic_resistance ARO:3006625 PDC-247 ARO:3006625 PDC-247 PDC-248 is a PDC beta-lactamase. PDC-248 antibiotic_resistance ARO:3006626 PDC-248 ARO:3006626 PDC-248 PDC-249 is a PDC beta-lactamase. PDC-249 antibiotic_resistance ARO:3006627 PDC-249 ARO:3006627 PDC-249 PDC-25 is a PDC beta-lactamase. PDC-25 antibiotic_resistance ARO:3006628 PDC-25 ARO:3006628 PDC-25 PDC-250 is a PDC beta-lactamase. PDC-250 antibiotic_resistance ARO:3006629 PDC-250 ARO:3006629 PDC-250 PDC-251 is a PDC beta-lactamase. PDC-251 antibiotic_resistance ARO:3006630 PDC-251 ARO:3006630 PDC-251 PDC-252 is a PDC beta-lactamase. PDC-252 antibiotic_resistance ARO:3006631 PDC-252 ARO:3006631 PDC-252 PDC-253 is a PDC beta-lactamase. PDC-253 antibiotic_resistance ARO:3006632 PDC-253 ARO:3006632 PDC-253 PDC-254 is a PDC beta-lactamase. PDC-254 antibiotic_resistance ARO:3006633 PDC-254 ARO:3006633 PDC-254 PDC-256 is a PDC beta-lactamase. PDC-256 antibiotic_resistance ARO:3006634 PDC-256 ARO:3006634 PDC-256 PDC-259 is a PDC beta-lactamase. PDC-259 antibiotic_resistance ARO:3006635 PDC-259 ARO:3006635 PDC-259 PDC-26 is a PDC beta-lactamase. PDC-26 antibiotic_resistance ARO:3006636 PDC-26 ARO:3006636 PDC-26 PDC-260 is a PDC beta-lactamase. PDC-260 antibiotic_resistance ARO:3006637 PDC-260 ARO:3006637 PDC-260 PDC-261 is a PDC beta-lactamase. PDC-261 antibiotic_resistance ARO:3006638 PDC-261 ARO:3006638 PDC-261 PDC-262 is a PDC beta-lactamase. PDC-262 antibiotic_resistance ARO:3006639 PDC-262 ARO:3006639 PDC-262 PDC-263 is a PDC beta-lactamase. PDC-263 antibiotic_resistance ARO:3006640 PDC-263 ARO:3006640 PDC-263 PDC-265 is a PDC beta-lactamase. PDC-265 antibiotic_resistance ARO:3006641 PDC-265 ARO:3006641 PDC-265 PDC-266 is a PDC beta-lactamase. PDC-266 antibiotic_resistance ARO:3006642 PDC-266 ARO:3006642 PDC-266 PDC-267 is a PDC beta-lactamase. PDC-267 antibiotic_resistance ARO:3006643 PDC-267 ARO:3006643 PDC-267 PDC-268 is a PDC beta-lactamase. PDC-268 antibiotic_resistance ARO:3006644 PDC-268 ARO:3006644 PDC-268 PDC-270 is a PDC beta-lactamase. PDC-270 antibiotic_resistance ARO:3006645 PDC-270 ARO:3006645 PDC-270 PDC-271 is a PDC beta-lactamase. PDC-271 antibiotic_resistance ARO:3006646 PDC-271 ARO:3006646 PDC-271 PDC-273 is a PDC beta-lactamase. PDC-273 antibiotic_resistance ARO:3006647 PDC-273 ARO:3006647 PDC-273 PDC-274 is a PDC beta-lactamase. PDC-274 antibiotic_resistance ARO:3006648 PDC-274 ARO:3006648 PDC-274 PDC-275 is a PDC beta-lactamase. PDC-275 antibiotic_resistance ARO:3006649 PDC-275 ARO:3006649 PDC-275 PDC-276 is a PDC beta-lactamase. PDC-276 antibiotic_resistance ARO:3006650 PDC-276 ARO:3006650 PDC-276 PDC-277 is a PDC beta-lactamase. PDC-277 antibiotic_resistance ARO:3006651 PDC-277 ARO:3006651 PDC-277 PDC-278 is a PDC beta-lactamase. PDC-278 antibiotic_resistance ARO:3006652 PDC-278 ARO:3006652 PDC-278 PDC-279 is a PDC beta-lactamase. PDC-279 antibiotic_resistance ARO:3006653 PDC-279 ARO:3006653 PDC-279 PDC-280 is a PDC beta-lactamase. PDC-280 antibiotic_resistance ARO:3006654 PDC-280 ARO:3006654 PDC-280 PDC-281 is a PDC beta-lactamase. PDC-281 antibiotic_resistance ARO:3006655 PDC-281 ARO:3006655 PDC-281 PDC-282 is a PDC beta-lactamase. PDC-282 antibiotic_resistance ARO:3006656 PDC-282 ARO:3006656 PDC-282 PDC-283 is a PDC beta-lactamase. PDC-283 antibiotic_resistance ARO:3006657 PDC-283 ARO:3006657 PDC-283 PDC-286 is a PDC beta-lactamase. PDC-286 antibiotic_resistance ARO:3006658 PDC-286 ARO:3006658 PDC-286 PDC-287 is a PDC beta-lactamase. PDC-287 antibiotic_resistance ARO:3006659 PDC-287 ARO:3006659 PDC-287 PDC-288 is a PDC beta-lactamase. PDC-288 antibiotic_resistance ARO:3006660 PDC-288 ARO:3006660 PDC-288 PDC-289 is a PDC beta-lactamase. PDC-289 antibiotic_resistance ARO:3006661 PDC-289 ARO:3006661 PDC-289 PDC-290 is a PDC beta-lactamase. PDC-290 antibiotic_resistance ARO:3006662 PDC-290 ARO:3006662 PDC-290 PDC-291 is a PDC beta-lactamase. PDC-291 antibiotic_resistance ARO:3006663 PDC-291 ARO:3006663 PDC-291 PDC-294 is a PDC beta-lactamase. PDC-294 antibiotic_resistance ARO:3006664 PDC-294 ARO:3006664 PDC-294 PDC-295 is a PDC beta-lactamase. PDC-295 antibiotic_resistance ARO:3006665 PDC-295 ARO:3006665 PDC-295 PDC-296 is a PDC beta-lactamase. PDC-296 antibiotic_resistance ARO:3006666 PDC-296 ARO:3006666 PDC-296 PDC-297 is a PDC beta-lactamase. PDC-297 antibiotic_resistance ARO:3006667 PDC-297 ARO:3006667 PDC-297 PDC-298 is a PDC beta-lactamase. PDC-298 antibiotic_resistance ARO:3006668 PDC-298 ARO:3006668 PDC-298 PDC-299 is a PDC beta-lactamase. PDC-299 antibiotic_resistance ARO:3006669 PDC-299 ARO:3006669 PDC-299 PDC-30 is a PDC beta-lactamase. PDC-30 antibiotic_resistance ARO:3006670 PDC-30 ARO:3006670 PDC-30 PDC-300 is a PDC beta-lactamase. PDC-300 antibiotic_resistance ARO:3006671 PDC-300 ARO:3006671 PDC-300 PDC-301 is a PDC beta-lactamase. PDC-301 antibiotic_resistance ARO:3006672 PDC-301 ARO:3006672 PDC-301 PDC-302 is a PDC beta-lactamase. PDC-302 antibiotic_resistance ARO:3006673 PDC-302 ARO:3006673 PDC-302 PDC-303 is a PDC beta-lactamase. PDC-303 antibiotic_resistance ARO:3006674 PDC-303 ARO:3006674 PDC-303 PDC-304 is a PDC beta-lactamase. PDC-304 antibiotic_resistance ARO:3006675 PDC-304 ARO:3006675 PDC-304 PDC-305 is a PDC beta-lactamase. PDC-305 antibiotic_resistance ARO:3006676 PDC-305 ARO:3006676 PDC-305 PDC-307 is a PDC beta-lactamase. PDC-307 antibiotic_resistance ARO:3006677 PDC-307 ARO:3006677 PDC-307 PDC-308 is a PDC beta-lactamase. PDC-308 antibiotic_resistance ARO:3006678 PDC-308 ARO:3006678 PDC-308 PDC-309 is a PDC beta-lactamase. PDC-309 antibiotic_resistance ARO:3006679 PDC-309 ARO:3006679 PDC-309 PDC-31 is a PDC beta-lactamase. PDC-31 antibiotic_resistance ARO:3006680 PDC-31 ARO:3006680 PDC-31 PDC-310 is a PDC beta-lactamase. PDC-310 antibiotic_resistance ARO:3006681 PDC-310 ARO:3006681 PDC-310 PDC-311 is a PDC beta-lactamase. PDC-311 antibiotic_resistance ARO:3006682 PDC-311 ARO:3006682 PDC-311 PDC-312 is a PDC beta-lactamase. PDC-312 antibiotic_resistance ARO:3006683 PDC-312 ARO:3006683 PDC-312 PDC-314 is a PDC beta-lactamase. PDC-314 antibiotic_resistance ARO:3006684 PDC-314 ARO:3006684 PDC-314 PDC-315 is a PDC beta-lactamase. PDC-315 antibiotic_resistance ARO:3006685 PDC-315 ARO:3006685 PDC-315 PDC-316 is a PDC beta-lactamase. PDC-316 antibiotic_resistance ARO:3006686 PDC-316 ARO:3006686 PDC-316 PDC-317 is a PDC beta-lactamase. PDC-317 antibiotic_resistance ARO:3006687 PDC-317 ARO:3006687 PDC-317 PDC-318 is a PDC beta-lactamase. PDC-318 antibiotic_resistance ARO:3006688 PDC-318 ARO:3006688 PDC-318 PDC-319 is a PDC beta-lactamase. PDC-319 antibiotic_resistance ARO:3006689 PDC-319 ARO:3006689 PDC-319 PDC-32 is a PDC beta-lactamase. PDC-32 antibiotic_resistance ARO:3006690 PDC-32 ARO:3006690 PDC-32 PDC-320 is a PDC beta-lactamase. PDC-320 antibiotic_resistance ARO:3006691 PDC-320 ARO:3006691 PDC-320 PDC-321 is a PDC beta-lactamase. PDC-321 antibiotic_resistance ARO:3006692 PDC-321 ARO:3006692 PDC-321 PDC-322 is a PDC beta-lactamase. PDC-322 antibiotic_resistance ARO:3006693 PDC-322 ARO:3006693 PDC-322 PDC-325 is a PDC beta-lactamase. PDC-325 antibiotic_resistance ARO:3006694 PDC-325 ARO:3006694 PDC-325 PDC-326 is a PDC beta-lactamase. PDC-326 antibiotic_resistance ARO:3006695 PDC-326 ARO:3006695 PDC-326 PDC-327 is a PDC beta-lactamase. PDC-327 antibiotic_resistance ARO:3006696 PDC-327 ARO:3006696 PDC-327 PDC-328 is a PDC beta-lactamase. PDC-328 antibiotic_resistance ARO:3006697 PDC-328 ARO:3006697 PDC-328 PDC-329 is a PDC beta-lactamase. PDC-329 antibiotic_resistance ARO:3006698 PDC-329 ARO:3006698 PDC-329 PDC-33 is a PDC beta-lactamase. PDC-33 antibiotic_resistance ARO:3006699 PDC-33 ARO:3006699 PDC-33 PDC-330 is a PDC beta-lactamase. PDC-330 antibiotic_resistance ARO:3006700 PDC-330 ARO:3006700 PDC-330 PDC-331 is a PDC beta-lactamase. PDC-331 antibiotic_resistance ARO:3006701 PDC-331 ARO:3006701 PDC-331 PDC-332 is a PDC beta-lactamase. PDC-332 antibiotic_resistance ARO:3006702 PDC-332 ARO:3006702 PDC-332 PDC-333 is a PDC beta-lactamase. PDC-333 antibiotic_resistance ARO:3006703 PDC-333 ARO:3006703 PDC-333 PDC-334 is a PDC beta-lactamase. PDC-334 antibiotic_resistance ARO:3006704 PDC-334 ARO:3006704 PDC-334 PDC-335 is a PDC beta-lactamase. PDC-335 antibiotic_resistance ARO:3006705 PDC-335 ARO:3006705 PDC-335 PDC-336 is a PDC beta-lactamase. PDC-336 antibiotic_resistance ARO:3006706 PDC-336 ARO:3006706 PDC-336 PDC-338 is a PDC beta-lactamase. PDC-338 antibiotic_resistance ARO:3006707 PDC-338 ARO:3006707 PDC-338 PDC-339 is a PDC beta-lactamase. PDC-339 antibiotic_resistance ARO:3006708 PDC-339 ARO:3006708 PDC-339 PDC-34 is a PDC beta-lactamase. PDC-34 antibiotic_resistance ARO:3006709 PDC-34 ARO:3006709 PDC-34 PDC-340 is a PDC beta-lactamase. PDC-340 antibiotic_resistance ARO:3006710 PDC-340 ARO:3006710 PDC-340 PDC-341 is a PDC beta-lactamase. PDC-341 antibiotic_resistance ARO:3006711 PDC-341 ARO:3006711 PDC-341 PDC-342 is a PDC beta-lactamase. PDC-342 antibiotic_resistance ARO:3006712 PDC-342 ARO:3006712 PDC-342 PDC-343 is a PDC beta-lactamase. PDC-343 antibiotic_resistance ARO:3006713 PDC-343 ARO:3006713 PDC-343 PDC-344 is a PDC beta-lactamase. PDC-344 antibiotic_resistance ARO:3006714 PDC-344 ARO:3006714 PDC-344 PDC-345 is a PDC beta-lactamase. PDC-345 antibiotic_resistance ARO:3006715 PDC-345 ARO:3006715 PDC-345 PDC-347 is a PDC beta-lactamase. PDC-347 antibiotic_resistance ARO:3006716 PDC-347 ARO:3006716 PDC-347 PDC-348 is a PDC beta-lactamase. PDC-348 antibiotic_resistance ARO:3006717 PDC-348 ARO:3006717 PDC-348 PDC-349 is a PDC beta-lactamase. PDC-349 antibiotic_resistance ARO:3006718 PDC-349 ARO:3006718 PDC-349 PDC-35 is a PDC beta-lactamase. PDC-35 antibiotic_resistance ARO:3006719 PDC-35 ARO:3006719 PDC-35 PDC-350 is a PDC beta-lactamase. PDC-350 antibiotic_resistance ARO:3006720 PDC-350 ARO:3006720 PDC-350 PDC-351 is a PDC beta-lactamase. PDC-351 antibiotic_resistance ARO:3006721 PDC-351 ARO:3006721 PDC-351 PDC-353 is a PDC beta-lactamase. PDC-353 antibiotic_resistance ARO:3006722 PDC-353 ARO:3006722 PDC-353 PDC-354 is a PDC beta-lactamase. PDC-354 antibiotic_resistance ARO:3006723 PDC-354 ARO:3006723 PDC-354 PDC-355 is a PDC beta-lactamase. PDC-355 antibiotic_resistance ARO:3006724 PDC-355 ARO:3006724 PDC-355 PDC-356 is a PDC beta-lactamase. PDC-356 antibiotic_resistance ARO:3006725 PDC-356 ARO:3006725 PDC-356 PDC-357 is a PDC beta-lactamase. PDC-357 antibiotic_resistance ARO:3006726 PDC-357 ARO:3006726 PDC-357 PDC-358 is a PDC beta-lactamase. PDC-358 antibiotic_resistance ARO:3006727 PDC-358 ARO:3006727 PDC-358 PDC-359 is a PDC beta-lactamase. PDC-359 antibiotic_resistance ARO:3006728 PDC-359 ARO:3006728 PDC-359 PDC-36 is a PDC beta-lactamase. PDC-36 antibiotic_resistance ARO:3006729 PDC-36 ARO:3006729 PDC-36 PDC-360 is a PDC beta-lactamase. PDC-360 antibiotic_resistance ARO:3006730 PDC-360 ARO:3006730 PDC-360 PDC-361 is a PDC beta-lactamase. PDC-361 antibiotic_resistance ARO:3006731 PDC-361 ARO:3006731 PDC-361 PDC-362 is a PDC beta-lactamase. PDC-362 antibiotic_resistance ARO:3006732 PDC-362 ARO:3006732 PDC-362 PDC-363 is a PDC beta-lactamase. PDC-363 antibiotic_resistance ARO:3006733 PDC-363 ARO:3006733 PDC-363 PDC-364 is a PDC beta-lactamase. PDC-364 antibiotic_resistance ARO:3006734 PDC-364 ARO:3006734 PDC-364 PDC-365 is a PDC beta-lactamase. PDC-365 antibiotic_resistance ARO:3006735 PDC-365 ARO:3006735 PDC-365 PDC-366 is a PDC beta-lactamase. PDC-366 antibiotic_resistance ARO:3006736 PDC-366 ARO:3006736 PDC-366 PDC-367 is a PDC beta-lactamase. PDC-367 antibiotic_resistance ARO:3006737 PDC-367 ARO:3006737 PDC-367 PDC-368 is a PDC beta-lactamase. PDC-368 antibiotic_resistance ARO:3006738 PDC-368 ARO:3006738 PDC-368 PDC-369 is a PDC beta-lactamase. PDC-369 antibiotic_resistance ARO:3006739 PDC-369 ARO:3006739 PDC-369 PDC-37 is a PDC beta-lactamase. PDC-37 antibiotic_resistance ARO:3006740 PDC-37 ARO:3006740 PDC-37 PDC-370 is a PDC beta-lactamase. PDC-370 antibiotic_resistance ARO:3006741 PDC-370 ARO:3006741 PDC-370 PDC-371 is a PDC beta-lactamase. PDC-371 antibiotic_resistance ARO:3006742 PDC-371 ARO:3006742 PDC-371 PDC-372 is a PDC beta-lactamase. PDC-372 antibiotic_resistance ARO:3006743 PDC-372 ARO:3006743 PDC-372 PDC-373 is a PDC beta-lactamase. PDC-373 antibiotic_resistance ARO:3006744 PDC-373 ARO:3006744 PDC-373 PDC-374 is a PDC beta-lactamase. PDC-374 antibiotic_resistance ARO:3006745 PDC-374 ARO:3006745 PDC-374 PDC-375 is a PDC beta-lactamase. PDC-375 antibiotic_resistance ARO:3006746 PDC-375 ARO:3006746 PDC-375 PDC-377 is a PDC beta-lactamase. PDC-377 antibiotic_resistance ARO:3006747 PDC-377 ARO:3006747 PDC-377 PDC-378 is a PDC beta-lactamase. PDC-378 antibiotic_resistance ARO:3006748 PDC-378 ARO:3006748 PDC-378 PDC-379 is a PDC beta-lactamase. PDC-379 antibiotic_resistance ARO:3006749 PDC-379 ARO:3006749 PDC-379 PDC-38 is a PDC beta-lactamase. PDC-38 antibiotic_resistance ARO:3006750 PDC-38 ARO:3006750 PDC-38 PDC-381 is a PDC beta-lactamase. PDC-381 antibiotic_resistance ARO:3006751 PDC-381 ARO:3006751 PDC-381 PDC-382 is a PDC beta-lactamase. PDC-382 antibiotic_resistance ARO:3006752 PDC-382 ARO:3006752 PDC-382 PDC-383 is a PDC beta-lactamase. PDC-383 antibiotic_resistance ARO:3006753 PDC-383 ARO:3006753 PDC-383 PDC-385 is a PDC beta-lactamase. PDC-385 antibiotic_resistance ARO:3006754 PDC-385 ARO:3006754 PDC-385 PDC-386 is a PDC beta-lactamase. PDC-386 antibiotic_resistance ARO:3006755 PDC-386 ARO:3006755 PDC-386 PDC-387 is a PDC beta-lactamase. PDC-387 antibiotic_resistance ARO:3006756 PDC-387 ARO:3006756 PDC-387 PDC-388 is a PDC beta-lactamase. PDC-388 antibiotic_resistance ARO:3006757 PDC-388 ARO:3006757 PDC-388 PDC-389 is a PDC beta-lactamase. PDC-389 antibiotic_resistance ARO:3006758 PDC-389 ARO:3006758 PDC-389 PDC-39 is a PDC beta-lactamase. PDC-39 antibiotic_resistance ARO:3006759 PDC-39 ARO:3006759 PDC-39 PDC-390 is a PDC beta-lactamase. PDC-390 antibiotic_resistance ARO:3006760 PDC-390 ARO:3006760 PDC-390 PDC-391 is a PDC beta-lactamase. PDC-391 antibiotic_resistance ARO:3006761 PDC-391 ARO:3006761 PDC-391 PDC-392 is a PDC beta-lactamase. PDC-392 antibiotic_resistance ARO:3006762 PDC-392 ARO:3006762 PDC-392 PDC-394 is a PDC beta-lactamase. PDC-394 antibiotic_resistance ARO:3006763 PDC-394 ARO:3006763 PDC-394 PDC-395 is a PDC beta-lactamase. PDC-395 antibiotic_resistance ARO:3006764 PDC-395 ARO:3006764 PDC-395 PDC-396 is a PDC beta-lactamase. PDC-396 antibiotic_resistance ARO:3006765 PDC-396 ARO:3006765 PDC-396 PDC-397 is a PDC beta-lactamase. PDC-397 antibiotic_resistance ARO:3006766 PDC-397 ARO:3006766 PDC-397 PDC-398 is a PDC beta-lactamase. PDC-398 antibiotic_resistance ARO:3006767 PDC-398 ARO:3006767 PDC-398 PDC-399 is a PDC beta-lactamase. PDC-399 antibiotic_resistance ARO:3006768 PDC-399 ARO:3006768 PDC-399 PDC-40 is a PDC beta-lactamase. PDC-40 antibiotic_resistance ARO:3006769 PDC-40 ARO:3006769 PDC-40 PDC-400 is a PDC beta-lactamase. PDC-400 antibiotic_resistance ARO:3006770 PDC-400 ARO:3006770 PDC-400 PDC-401 is a PDC beta-lactamase. PDC-401 antibiotic_resistance ARO:3006771 PDC-401 ARO:3006771 PDC-401 PDC-402 is a PDC beta-lactamase. PDC-402 antibiotic_resistance ARO:3006772 PDC-402 ARO:3006772 PDC-402 PDC-403 is a PDC beta-lactamase. PDC-403 antibiotic_resistance ARO:3006773 PDC-403 ARO:3006773 PDC-403 PDC-404 is a PDC beta-lactamase. PDC-404 antibiotic_resistance ARO:3006774 PDC-404 ARO:3006774 PDC-404 PDC-405 is a PDC beta-lactamase. PDC-405 antibiotic_resistance ARO:3006775 PDC-405 ARO:3006775 PDC-405 PDC-406 is a PDC beta-lactamase. PDC-406 antibiotic_resistance ARO:3006776 PDC-406 ARO:3006776 PDC-406 PDC-407 is a PDC beta-lactamase. PDC-407 antibiotic_resistance ARO:3006777 PDC-407 ARO:3006777 PDC-407 PDC-408 is a PDC beta-lactamase. PDC-408 antibiotic_resistance ARO:3006778 PDC-408 ARO:3006778 PDC-408 PDC-409 is a PDC beta-lactamase. PDC-409 antibiotic_resistance ARO:3006779 PDC-409 ARO:3006779 PDC-409 PDC-410 is a PDC beta-lactamase. PDC-410 antibiotic_resistance ARO:3006780 PDC-410 ARO:3006780 PDC-410 PDC-411 is a PDC beta-lactamase. PDC-411 antibiotic_resistance ARO:3006781 PDC-411 ARO:3006781 PDC-411 PDC-412 is a PDC beta-lactamase. PDC-412 antibiotic_resistance ARO:3006782 PDC-412 ARO:3006782 PDC-412 PDC-414 is a PDC beta-lactamase. PDC-414 antibiotic_resistance ARO:3006783 PDC-414 ARO:3006783 PDC-414 PDC-415 is a PDC beta-lactamase. PDC-415 antibiotic_resistance ARO:3006784 PDC-415 ARO:3006784 PDC-415 PDC-416 is a PDC beta-lactamase. PDC-416 antibiotic_resistance ARO:3006785 PDC-416 ARO:3006785 PDC-416 PDC-417 is a PDC beta-lactamase. PDC-417 antibiotic_resistance ARO:3006786 PDC-417 ARO:3006786 PDC-417 PDC-418 is a PDC beta-lactamase. PDC-418 antibiotic_resistance ARO:3006787 PDC-418 ARO:3006787 PDC-418 PDC-419 is a PDC beta-lactamase. PDC-419 antibiotic_resistance ARO:3006788 PDC-419 ARO:3006788 PDC-419 PDC-42 is a PDC beta-lactamase. PDC-42 antibiotic_resistance ARO:3006789 PDC-42 ARO:3006789 PDC-42 PDC-420 is a PDC beta-lactamase. PDC-420 antibiotic_resistance ARO:3006790 PDC-420 ARO:3006790 PDC-420 PDC-421 is a PDC beta-lactamase. PDC-421 antibiotic_resistance ARO:3006791 PDC-421 ARO:3006791 PDC-421 PDC-422 is a PDC beta-lactamase. PDC-422 antibiotic_resistance ARO:3006792 PDC-422 ARO:3006792 PDC-422 PDC-423 is a PDC beta-lactamase. PDC-423 antibiotic_resistance ARO:3006793 PDC-423 ARO:3006793 PDC-423 PDC-424 is a PDC beta-lactamase. PDC-424 antibiotic_resistance ARO:3006794 PDC-424 ARO:3006794 PDC-424 PDC-425 is a PDC beta-lactamase. PDC-425 antibiotic_resistance ARO:3006795 PDC-425 ARO:3006795 PDC-425 PDC-426 is a PDC beta-lactamase. PDC-426 antibiotic_resistance ARO:3006796 PDC-426 ARO:3006796 PDC-426 PDC-427 is a PDC beta-lactamase. PDC-427 antibiotic_resistance ARO:3006797 PDC-427 ARO:3006797 PDC-427 PDC-428 is a PDC beta-lactamase. PDC-428 antibiotic_resistance ARO:3006798 PDC-428 ARO:3006798 PDC-428 PDC-430 is a PDC beta-lactamase. PDC-430 antibiotic_resistance ARO:3006799 PDC-430 ARO:3006799 PDC-430 PDC-431 is a PDC beta-lactamase. PDC-431 antibiotic_resistance ARO:3006800 PDC-431 ARO:3006800 PDC-431 PDC-432 is a PDC beta-lactamase. PDC-432 antibiotic_resistance ARO:3006801 PDC-432 ARO:3006801 PDC-432 PDC-433 is a PDC beta-lactamase. PDC-433 antibiotic_resistance ARO:3006802 PDC-433 ARO:3006802 PDC-433 PDC-434 is a PDC beta-lactamase. PDC-434 antibiotic_resistance ARO:3006803 PDC-434 ARO:3006803 PDC-434 PDC-435 is a PDC beta-lactamase. PDC-435 antibiotic_resistance ARO:3006804 PDC-435 ARO:3006804 PDC-435 PDC-436 is a PDC beta-lactamase. PDC-436 antibiotic_resistance ARO:3006805 PDC-436 ARO:3006805 PDC-436 PDC-437 is a PDC beta-lactamase. PDC-437 antibiotic_resistance ARO:3006806 PDC-437 ARO:3006806 PDC-437 PDC-439 is a PDC beta-lactamase. PDC-439 antibiotic_resistance ARO:3006807 PDC-439 ARO:3006807 PDC-439 PDC-440 is a PDC beta-lactamase. PDC-440 antibiotic_resistance ARO:3006808 PDC-440 ARO:3006808 PDC-440 PDC-441 is a PDC beta-lactamase. PDC-441 antibiotic_resistance ARO:3006809 PDC-441 ARO:3006809 PDC-441 PDC-442 is a PDC beta-lactamase. PDC-442 antibiotic_resistance ARO:3006810 PDC-442 ARO:3006810 PDC-442 PDC-443 is a PDC beta-lactamase. PDC-443 antibiotic_resistance ARO:3006811 PDC-443 ARO:3006811 PDC-443 PDC-444 is a PDC beta-lactamase. PDC-444 antibiotic_resistance ARO:3006812 PDC-444 ARO:3006812 PDC-444 PDC-445 is a PDC beta-lactamase. PDC-445 antibiotic_resistance ARO:3006813 PDC-445 ARO:3006813 PDC-445 PDC-446 is a PDC beta-lactamase. PDC-446 antibiotic_resistance ARO:3006814 PDC-446 ARO:3006814 PDC-446 PDC-447 is a PDC beta-lactamase. PDC-447 antibiotic_resistance ARO:3006815 PDC-447 ARO:3006815 PDC-447 PDC-448 is a PDC beta-lactamase. PDC-448 antibiotic_resistance ARO:3006816 PDC-448 ARO:3006816 PDC-448 PDC-450 is a PDC beta-lactamase. PDC-450 antibiotic_resistance ARO:3006817 PDC-450 ARO:3006817 PDC-450 PDC-451 is a PDC beta-lactamase. PDC-451 antibiotic_resistance ARO:3006818 PDC-451 ARO:3006818 PDC-451 PDC-452 is a PDC beta-lactamase. PDC-452 antibiotic_resistance ARO:3006819 PDC-452 ARO:3006819 PDC-452 PDC-453 is a PDC beta-lactamase. PDC-453 antibiotic_resistance ARO:3006820 PDC-453 ARO:3006820 PDC-453 PDC-454 is a PDC beta-lactamase. PDC-454 antibiotic_resistance ARO:3006821 PDC-454 ARO:3006821 PDC-454 PDC-455 is a PDC beta-lactamase. PDC-455 antibiotic_resistance ARO:3006822 PDC-455 ARO:3006822 PDC-455 PDC-456 is a PDC beta-lactamase. PDC-456 antibiotic_resistance ARO:3006823 PDC-456 ARO:3006823 PDC-456 PDC-457 is a PDC beta-lactamase. PDC-457 antibiotic_resistance ARO:3006824 PDC-457 ARO:3006824 PDC-457 PDC-458 is a PDC beta-lactamase. PDC-458 antibiotic_resistance ARO:3006825 PDC-458 ARO:3006825 PDC-458 PDC-459 is a PDC beta-lactamase. PDC-459 antibiotic_resistance ARO:3006826 PDC-459 ARO:3006826 PDC-459 PDC-46 is a PDC beta-lactamase. PDC-46 antibiotic_resistance ARO:3006827 PDC-46 ARO:3006827 PDC-46 PDC-460 is a PDC beta-lactamase. PDC-460 antibiotic_resistance ARO:3006828 PDC-460 ARO:3006828 PDC-460 PDC-462 is a PDC beta-lactamase. PDC-462 antibiotic_resistance ARO:3006829 PDC-462 ARO:3006829 PDC-462 PDC-463 is a PDC beta-lactamase. PDC-463 antibiotic_resistance ARO:3006830 PDC-463 ARO:3006830 PDC-463 PDC-465 is a PDC beta-lactamase. PDC-465 antibiotic_resistance ARO:3006831 PDC-465 ARO:3006831 PDC-465 PDC-466 is a PDC beta-lactamase. PDC-466 antibiotic_resistance ARO:3006832 PDC-466 ARO:3006832 PDC-466 PDC-467 is a PDC beta-lactamase. PDC-467 antibiotic_resistance ARO:3006833 PDC-467 ARO:3006833 PDC-467 PDC-468 is a PDC beta-lactamase. PDC-468 antibiotic_resistance ARO:3006834 PDC-468 ARO:3006834 PDC-468 PDC-469 is a PDC beta-lactamase. PDC-469 antibiotic_resistance ARO:3006835 PDC-469 ARO:3006835 PDC-469 PDC-470 is a PDC beta-lactamase. PDC-470 antibiotic_resistance ARO:3006836 PDC-470 ARO:3006836 PDC-470 PDC-471 is a PDC beta-lactamase. PDC-471 antibiotic_resistance ARO:3006837 PDC-471 ARO:3006837 PDC-471 PDC-472 is a PDC beta-lactamase. PDC-472 antibiotic_resistance ARO:3006838 PDC-472 ARO:3006838 PDC-472 PDC-473 is a PDC beta-lactamase. PDC-473 antibiotic_resistance ARO:3006839 PDC-473 ARO:3006839 PDC-473 PDC-474 is a PDC beta-lactamase. PDC-474 antibiotic_resistance ARO:3006840 PDC-474 ARO:3006840 PDC-474 PDC-475 is a PDC beta-lactamase. PDC-475 antibiotic_resistance ARO:3006841 PDC-475 ARO:3006841 PDC-475 PDC-476 is a PDC beta-lactamase. PDC-476 antibiotic_resistance ARO:3006842 PDC-476 ARO:3006842 PDC-476 PDC-58 is a PDC beta-lactamase. PDC-58 antibiotic_resistance ARO:3006843 PDC-58 ARO:3006843 PDC-58 PDC-60 is a PDC beta-lactamase. PDC-60 antibiotic_resistance ARO:3006844 PDC-60 ARO:3006844 PDC-60 PDC-64 is a PDC beta-lactamase. PDC-64 antibiotic_resistance ARO:3006845 PDC-64 ARO:3006845 PDC-64 PDC-71 is a PDC beta-lactamase. PDC-71 antibiotic_resistance ARO:3006846 PDC-71 ARO:3006846 PDC-71 PDC-94 is a PDC beta-lactamase. PDC-94 antibiotic_resistance ARO:3006847 PDC-94 ARO:3006847 PDC-94 PDC-95 is a PDC beta-lactamase. PDC-95 antibiotic_resistance ARO:3006848 PDC-95 ARO:3006848 PDC-95 PDC-96 is a PDC beta-lactamase. PDC-96 antibiotic_resistance ARO:3006849 PDC-96 ARO:3006849 PDC-96 PDC-97 is a PDC beta-lactamase. PDC-97 antibiotic_resistance ARO:3006850 PDC-97 ARO:3006850 PDC-97 PDC-98 is a PDC beta-lactamase. PDC-98 antibiotic_resistance ARO:3006851 PDC-98 ARO:3006851 PDC-98 PDC-99 is a PDC beta-lactamase. PDC-99 antibiotic_resistance ARO:3006852 PDC-99 ARO:3006852 PDC-99 SRT-3 is a SRT beta-lactamase. SRT-3 antibiotic_resistance ARO:3006853 SRT-3 ARO:3006853 SRT-3 CMH-2 is a CMH beta-lactamase. CMH-2 antibiotic_resistance ARO:3006854 CMH-2 ARO:3006854 CMH-2 CMH-3 is a CMH beta-lactamase. CMH-3 antibiotic_resistance ARO:3006855 CMH-3 ARO:3006855 CMH-3 CMH-4 is a CMH beta-lactamase. CMH-4 antibiotic_resistance ARO:3006856 CMH-4 ARO:3006856 CMH-4 CMH-5 is a CMH beta-lactamase. CMH-5 antibiotic_resistance ARO:3006857 CMH-5 ARO:3006857 CMH-5 CMH-6 is a CMH beta-lactamase. CMH-6 antibiotic_resistance ARO:3006858 CMH-6 ARO:3006858 CMH-6 MIR-19 is a MIR beta-lactamase. MIR-19 antibiotic_resistance ARO:3006859 MIR-19 ARO:3006859 MIR-19 MIR-20 is a MIR beta-lactamase. MIR-20 antibiotic_resistance ARO:3006860 MIR-20 ARO:3006860 MIR-20 MIR-21 is a MIR beta-lactamase. MIR-21 antibiotic_resistance ARO:3006861 MIR-21 ARO:3006861 MIR-21 MIR-22 is a MIR beta-lactamase. MIR-22 antibiotic_resistance ARO:3006862 MIR-22 ARO:3006862 MIR-22 AAK-1 is a AAK beta-lactamase. AAK-1 antibiotic_resistance ARO:3006863 AAK-1 ARO:3006863 AAK-1 CRD3-1 is a CRD3 beta-lactamase. CRD3-1 antibiotic_resistance ARO:3006864 CRD3-1 ARO:3006864 CRD3-1 CRH-1 is a CRH beta-lactamase. CRH-1 antibiotic_resistance ARO:3006865 CRH-1 ARO:3006865 CRH-1 CRH-2 is a CRH beta-lactamase. CRH-2 antibiotic_resistance ARO:3006866 CRH-2 ARO:3006866 CRH-2 CRH-3 is a CRH beta-lactamase. CRH-3 antibiotic_resistance ARO:3006867 CRH-3 ARO:3006867 CRH-3 CRP-1 is a CRP beta-lactamase. CRP-1 antibiotic_resistance ARO:3006868 CRP-1 ARO:3006868 CRP-1 CSA-1 is a CSA beta-lactamase. CSA-1 antibiotic_resistance ARO:3006869 CSA-1 ARO:3006869 CSA-1 CSA-2 is a CSA beta-lactamase. CSA-2 antibiotic_resistance ARO:3006870 CSA-2 ARO:3006870 CSA-2 CSP-1 is a CSP beta-lactamase. CSP-1 antibiotic_resistance ARO:3006871 CSP-1 ARO:3006871 CSP-1 DHT2-1 is a DHT2 beta-lactamase. DHT2-1 antibiotic_resistance ARO:3006872 DHT2-1 ARO:3006872 DHT2-1 EAM-1 is a EAM beta-lactamase. EAM-1 antibiotic_resistance ARO:3006873 EAM-1 ARO:3006873 EAM-1 EC-13 is a EC beta-lactamase. EC-13 antibiotic_resistance ARO:3006874 EC-13 ARO:3006874 EC-13 EC-14 is a EC beta-lactamase. EC-14 antibiotic_resistance ARO:3006875 EC-14 ARO:3006875 EC-14 EC-15 is a EC beta-lactamase. EC-15 antibiotic_resistance ARO:3006876 EC-15 ARO:3006876 EC-15 EC-16 is a EC beta-lactamase. EC-16 antibiotic_resistance ARO:3006877 EC-16 ARO:3006877 EC-16 EC-18 is a EC beta-lactamase. EC-18 antibiotic_resistance ARO:3006878 EC-18 ARO:3006878 EC-18 EC-19 is a EC beta-lactamase. EC-19 antibiotic_resistance ARO:3006879 EC-19 ARO:3006879 EC-19 EC-5 is a EC beta-lactamase. EC-5 antibiotic_resistance ARO:3006880 EC-5 ARO:3006880 EC-5 EC-8 is a EC beta-lactamase. EC-8 antibiotic_resistance ARO:3006881 EC-8 ARO:3006881 EC-8 ECM-1 is a ECM beta-lactamase. ECM-1 antibiotic_resistance ARO:3006882 ECM-1 ARO:3006882 ECM-1 ECV-1 is a ECV beta-lactamase. ECV-1 antibiotic_resistance ARO:3006883 ECV-1 ARO:3006883 ECV-1 EFM-1 is a EFM beta-lactamase. EFM-1 antibiotic_resistance ARO:3006884 EFM-1 ARO:3006884 EFM-1 ELM-1 is a ELM beta-lactamase. ELM-1 antibiotic_resistance ARO:3006885 ELM-1 ARO:3006885 ELM-1 EVM-1 is a EVM beta-lactamase. EVM-1 antibiotic_resistance ARO:3006886 EVM-1 ARO:3006886 EVM-1 FIA-1 is a FIA beta-lactamase. FIA-1 antibiotic_resistance ARO:3006887 FIA-1 ARO:3006887 FIA-1 GIL-1 is a GIL beta-lactamase. GIL-1 antibiotic_resistance ARO:3006888 GIL-1 ARO:3006888 GIL-1 GMB-1 is a GMB beta-lactamase. GMB-1 antibiotic_resistance ARO:3006889 GMB-1 ARO:3006889 GMB-1 is a GMB beta-lactamase. PMID:35257174 GMB-1 AFM-1 is a AFM beta-lactamase. AFM-1 antibiotic_resistance ARO:3006890 AFM-1 ARO:3006890 AFM-1 AFM-2 is a AFM beta-lactamase. AFM-2 antibiotic_resistance ARO:3006891 AFM-2 ARO:3006891 AFM-2 ALG11-1 is a ALG11 beta-lactamase. ALG11-1 antibiotic_resistance ARO:3006892 ALG11-1 ARO:3006892 ALG11-1 ALG6-1 is a ALG6 beta-lactamase. ALG6-1 antibiotic_resistance ARO:3006893 ALG6-1 ARO:3006893 ALG6-1 ALI-1 is a ALI beta-lactamase. ALI-1 antibiotic_resistance ARO:3006894 ALI-1 ARO:3006894 ALI-1 ALI-2 is a ALI beta-lactamase. ALI-2 antibiotic_resistance ARO:3006895 ALI-2 ARO:3006895 ALI-2 ANA-1 is a ANA beta-lactamase. ANA-1 antibiotic_resistance ARO:3006896 ANA-1 ARO:3006896 ANA-1 AXC-1 is a AXC beta-lactamase. AXC-1 antibiotic_resistance ARO:3006897 AXC-1 ARO:3006897 AXC-1 AXC-2 is a AXC beta-lactamase. AXC-2 antibiotic_resistance ARO:3006898 AXC-2 ARO:3006898 AXC-2 AXC-3 is a AXC beta-lactamase. AXC-3 antibiotic_resistance ARO:3006899 AXC-3 ARO:3006899 AXC-3 AXC-4 is a AXC beta-lactamase. AXC-4 antibiotic_resistance ARO:3006900 AXC-4 ARO:3006900 AXC-4 AXC-5 is a AXC beta-lactamase. AXC-5 antibiotic_resistance ARO:3006901 AXC-5 ARO:3006901 AXC-5 BSU-1 is a BSU beta-lactamase. BSU-1 antibiotic_resistance ARO:3006902 BSU-1 ARO:3006902 BSU-1 CAR-1 is a CAR beta-lactamase. CAR-1 antibiotic_resistance ARO:3006903 CAR-1 ARO:3006903 CAR-1 CDD-1 is a CDD beta-lactamase. CDD-1 antibiotic_resistance ARO:3006904 CDD-1 ARO:3006904 CDD-1 CDD-2 is a CDD beta-lactamase. CDD-2 antibiotic_resistance ARO:3006905 CDD-2 ARO:3006905 CDD-2 CfiA10 is a CfiA beta-lactamase. CfiA10 antibiotic_resistance ARO:3006906 CfiA10 ARO:3006906 CfiA10 CfiA11 is a CfiA beta-lactamase. CfiA11 antibiotic_resistance ARO:3006907 CfiA11 ARO:3006907 CfiA11 CfiA14 is a CfiA beta-lactamase. CfiA14 antibiotic_resistance ARO:3006908 CfiA14 ARO:3006908 CfiA14 CfiA17 is a CfiA beta-lactamase. CfiA17 antibiotic_resistance ARO:3006909 CfiA17 ARO:3006909 CfiA17 CfiA18 is a CfiA beta-lactamase. CfiA18 antibiotic_resistance ARO:3006910 CfiA18 ARO:3006910 CfiA18 CfiA19 is a CfiA beta-lactamase. CfiA19 antibiotic_resistance ARO:3006911 CfiA19 ARO:3006911 CfiA19 CfiA2 is a CfiA beta-lactamase. CfiA2 antibiotic_resistance ARO:3006912 CfiA2 ARO:3006912 CfiA2 CfiA21 is a CfiA beta-lactamase. CfiA21 antibiotic_resistance ARO:3006913 CfiA21 ARO:3006913 CfiA21 CfiA22 is a CfiA beta-lactamase. CfiA22 antibiotic_resistance ARO:3006914 CfiA22 ARO:3006914 CfiA22 CfiA23 is a CfiA beta-lactamase. CfiA23 antibiotic_resistance ARO:3006915 CfiA23 ARO:3006915 CfiA23 CfiA24 is a CfiA beta-lactamase. CfiA24 antibiotic_resistance ARO:3006916 CfiA24 ARO:3006916 CfiA24 CfiA26 is a CfiA beta-lactamase. CfiA26 antibiotic_resistance ARO:3006917 CfiA26 ARO:3006917 CfiA26 CfiA27 is a CfiA beta-lactamase. CfiA27 antibiotic_resistance ARO:3006918 CfiA27 ARO:3006918 CfiA27 CfiA4 is a CfiA beta-lactamase. CfiA4 antibiotic_resistance ARO:3006919 CfiA4 ARO:3006919 CfiA4 CfiA8 is a CfiA beta-lactamase. CfiA8 antibiotic_resistance ARO:3006920 CfiA8 ARO:3006920 CfiA8 CfiA9 is a CfiA beta-lactamase. CfiA9 antibiotic_resistance ARO:3006921 CfiA9 ARO:3006921 CfiA9 CMA-1 is a CMA beta-lactamase. CMA-1 antibiotic_resistance ARO:3006922 CMA-1 ARO:3006922 CMA-1 CMA-2 is a CMA beta-lactamase. CMA-2 antibiotic_resistance ARO:3006923 CMA-2 ARO:3006923 CMA-2 CVI-1 is a CVI beta-lactamase. CVI-1 antibiotic_resistance ARO:3006924 CVI-1 ARO:3006924 CVI-1 GRD23-1 is a GRD23 beta-lactamase. GRD23-1 antibiotic_resistance ARO:3006925 GRD23-1 ARO:3006925 GRD23-1 GRD33-1 is a GRD33 beta-lactamase. GRD33-1 antibiotic_resistance ARO:3006926 GRD33-1 ARO:3006926 GRD33-1 KLUC-1 is a KLUC beta-lactamase. KLUC-1 antibiotic_resistance ARO:3006927 KLUC-1 ARO:3006927 KLUC-1 KLUC-2 is a KLUC beta-lactamase. KLUC-2 antibiotic_resistance ARO:3006928 KLUC-2 ARO:3006928 KLUC-2 KLUC-3 is a KLUC beta-lactamase. KLUC-3 antibiotic_resistance ARO:3006929 KLUC-3 ARO:3006929 KLUC-3 KLUC-4 is a KLUC beta-lactamase. KLUC-4 antibiotic_resistance ARO:3006930 KLUC-4 ARO:3006930 KLUC-4 KLUC-5 is a KLUC beta-lactamase. KLUC-5 antibiotic_resistance ARO:3006931 KLUC-5 ARO:3006931 KLUC-5 LEN-27 is a LEN beta-lactamase. LEN-27 antibiotic_resistance ARO:3006932 LEN-27 ARO:3006932 LEN-27 LEN-28 is a LEN beta-lactamase. LEN-28 antibiotic_resistance ARO:3006933 LEN-28 ARO:3006933 LEN-28 LEN-31 is a LEN beta-lactamase. LEN-31 antibiotic_resistance ARO:3006934 LEN-31 ARO:3006934 LEN-31 LHK-1 is a LHK beta-lactamase. LHK-1 antibiotic_resistance ARO:3006935 LHK-1 ARO:3006935 LHK-1 LHK-2 is a LHK beta-lactamase. LHK-2 antibiotic_resistance ARO:3006936 LHK-2 ARO:3006936 LHK-2 LHK-3 is a LHK beta-lactamase. LHK-3 antibiotic_resistance ARO:3006937 LHK-3 ARO:3006937 LHK-3 LHK-4 is a LHK beta-lactamase. LHK-4 antibiotic_resistance ARO:3006938 LHK-4 ARO:3006938 LHK-4 LHK-5 is a LHK beta-lactamase. LHK-5 antibiotic_resistance ARO:3006939 LHK-5 ARO:3006939 LHK-5 LHK-6 is a LHK beta-lactamase. LHK-6 antibiotic_resistance ARO:3006940 LHK-6 ARO:3006940 LHK-6 LRG-1 is a LRG beta-lactamase. LRG-1 antibiotic_resistance ARO:3006941 LRG-1 ARO:3006941 LRG-1 LUS-1 is a LUS beta-lactamase. LUS-1 antibiotic_resistance ARO:3006942 LUS-1 ARO:3006942 LUS-1 LUT-1 is a LUT beta-lactamase. LUT-1 antibiotic_resistance ARO:3006943 LUT-1 ARO:3006943 LUT-1 LUT-2 is a LUT beta-lactamase. LUT-2 antibiotic_resistance ARO:3006944 LUT-2 ARO:3006944 LUT-2 LUT-3 is a LUT beta-lactamase. LUT-3 antibiotic_resistance ARO:3006945 LUT-3 ARO:3006945 LUT-3 LUT-4 is a LUT beta-lactamase. LUT-4 antibiotic_resistance ARO:3006946 LUT-4 ARO:3006946 LUT-4 LUT-5 is a LUT beta-lactamase. LUT-5 antibiotic_resistance ARO:3006947 LUT-5 ARO:3006947 LUT-5 LUT-6 is a LUT beta-lactamase. LUT-6 antibiotic_resistance ARO:3006948 LUT-6 ARO:3006948 LUT-6 MAL-1 is a MAL beta-lactamase. MAL-1 antibiotic_resistance ARO:3006949 MAL-1 ARO:3006949 MAL-1 MAL-2 is a MAL beta-lactamase. MAL-2 antibiotic_resistance ARO:3006950 MAL-2 ARO:3006950 MAL-2 MBL1b is a MBL beta-lactamase. MBL1b antibiotic_resistance ARO:3006951 MBL1b ARO:3006951 MBL1b MOC-1 is a MOC beta-lactamase. MOC-1 antibiotic_resistance ARO:3006952 MOC-1 ARO:3006952 MOC-1 MOR-2 is a MOR beta-lactamase. MOR-2 antibiotic_resistance ARO:3006953 MOR-2 ARO:3006953 MOR-2 MYO-1 is a MYO beta-lactamase. MYO-1 antibiotic_resistance ARO:3006954 MYO-1 ARO:3006954 MYO-1 MYX-1 is a MYX beta-lactamase. MYX-1 antibiotic_resistance ARO:3006955 MYX-1 ARO:3006955 MYX-1 OHIO-1 is a OHIO beta-lactamase. OHIO-1 antibiotic_resistance ARO:3006956 OHIO-1 ARO:3006956 OHIO-1 ORN-1 is a ORN beta-lactamase. ORN-1 antibiotic_resistance ARO:3006957 ORN-1 ARO:3006957 ORN-1 ORN-2 is a ORN beta-lactamase. ORN-2 antibiotic_resistance ARO:3006958 ORN-2 ARO:3006958 ORN-2 ORN-3 is a ORN beta-lactamase. ORN-3 antibiotic_resistance ARO:3006959 ORN-3 ARO:3006959 ORN-3 ORN-4 is a ORN beta-lactamase. ORN-4 antibiotic_resistance ARO:3006960 ORN-4 ARO:3006960 ORN-4 ORN-5 is a ORN beta-lactamase. ORN-5 antibiotic_resistance ARO:3006961 ORN-5 ARO:3006961 ORN-5 ORN-6 is a ORN beta-lactamase. ORN-6 antibiotic_resistance ARO:3006962 ORN-6 ARO:3006962 ORN-6 ORR-1 is a ORR beta-lactamase. ORR-1 antibiotic_resistance ARO:3006963 ORR-1 ARO:3006963 ORR-1 PAU-1 is a PAU beta-lactamase. PAU-1 antibiotic_resistance ARO:3006964 PAU-1 ARO:3006964 PAU-1 PFM-1 is a PFM beta-lactamase. PFM-1 antibiotic_resistance ARO:3006965 PFM-1 ARO:3006965 PFM-1 PFM-2 is a PFM beta-lactamase. PFM-2 antibiotic_resistance ARO:3006966 PFM-2 ARO:3006966 PFM-2 PFM-3 is a PFM beta-lactamase. PFM-3 antibiotic_resistance ARO:3006967 PFM-3 ARO:3006967 PFM-3 PLA-1 is a PLA beta-lactamase. PLA-1 antibiotic_resistance ARO:3006968 PLA-1 ARO:3006968 PLA-1 PLA-2a is a PLA beta-lactamase. PLA-2a antibiotic_resistance ARO:3006969 PLA-2a ARO:3006969 PLA-2a PLA-3 is a PLA beta-lactamase. PLA-3 antibiotic_resistance ARO:3006970 PLA-3 ARO:3006970 PLA-3 PLA-6 is a PLA beta-lactamase. PLA-6 antibiotic_resistance ARO:3006971 PLA-6 ARO:3006971 PLA-6 PLN-1 is a PLN beta-lactamase. PLN-1 antibiotic_resistance ARO:3006972 PLN-1 ARO:3006972 PLN-1 PME-1 is a PME beta-lactamase. PME-1 antibiotic_resistance ARO:3006973 PME-1 ARO:3006973 PME-1 POM-1 is a POM beta-lactamase. POM-1 antibiotic_resistance ARO:3006974 POM-1 ARO:3006974 POM-1 POM-2 is a POM beta-lactamase. POM-2 antibiotic_resistance ARO:3006975 POM-2 ARO:3006975 POM-2 PST-1 is a PST beta-lactamase. PST-1 antibiotic_resistance ARO:3006976 PST-1 ARO:3006976 PST-1 PST-2 is a PST beta-lactamase. PST-2 antibiotic_resistance ARO:3006977 PST-2 ARO:3006977 PST-2 PSV-1 is a PSV beta-lactamase. PSV-1 antibiotic_resistance ARO:3006978 PSV-1 ARO:3006978 PSV-1 RAHN-1 is a RAHN beta-lactamase. RAHN-1 antibiotic_resistance ARO:3006979 RAHN-1 ARO:3006979 RAHN-1 RAHN-2 is a RAHN beta-lactamase. RAHN-2 antibiotic_resistance ARO:3006980 RAHN-2 ARO:3006980 RAHN-2 RSA2-1 is a RSA2 beta-lactamase. RSA2-1 antibiotic_resistance ARO:3006981 RSA2-1 ARO:3006981 RSA2-1 is a RSA2 beta-lactamase. PMID:29316517 RSA2-1 RSD2-1 is a RSD2 beta-lactamase. RSD2-1 antibiotic_resistance ARO:3006982 RSD2-1 ARO:3006982 RSD2-1 RSD2-2 is a RSD2 beta-lactamase. RSD2-2 antibiotic_resistance ARO:3006983 RSD2-2 ARO:3006983 RSD2-2 RUB-1 is a RUB beta-lactamase. RUB-1 antibiotic_resistance ARO:3006984 RUB-1 ARO:3006984 RUB-1 SFC-1 is a SFC beta-lactamase. SFC-1 antibiotic_resistance ARO:3006985 SFC-1 ARO:3006985 SFC-1 SFO-1 is a SFO beta-lactamase. SFO-1 antibiotic_resistance ARO:3006986 SFO-1 ARO:3006986 SFO-1 SGM-1 is a SGM beta-lactamase. SGM-1 antibiotic_resistance ARO:3006987 SGM-1 ARO:3006987 SGM-1 SGM-2 is a SGM beta-lactamase. SGM-2 antibiotic_resistance ARO:3006988 SGM-2 ARO:3006988 SGM-2 SGM-3 is a SGM beta-lactamase. SGM-3 antibiotic_resistance ARO:3006989 SGM-3 ARO:3006989 SGM-3 SGM-4 is a SGM beta-lactamase. SGM-4 antibiotic_resistance ARO:3006990 SGM-4 ARO:3006990 SGM-4 SGM-5 is a SGM beta-lactamase. SGM-5 antibiotic_resistance ARO:3006991 SGM-5 ARO:3006991 SGM-5 SGM-6 is a SGM beta-lactamase. SGM-6 antibiotic_resistance ARO:3006992 SGM-6 ARO:3006992 SGM-6 SGM-7 is a SGM beta-lactamase. SGM-7 antibiotic_resistance ARO:3006993 SGM-7 ARO:3006993 SGM-7 SHN-1 is a SHN beta-lactamase. SHN-1 antibiotic_resistance ARO:3006994 SHN-1 ARO:3006994 SHN-1 SPN79-1 is a SPN79 beta-lactamase. SPN79-1 antibiotic_resistance ARO:3006995 SPN79-1 ARO:3006995 SPN79-1 SPR-1 is a SPR beta-lactamase. SPR-1 antibiotic_resistance ARO:3006996 SPR-1 ARO:3006996 SPR-1 SPS-1 is a SPS beta-lactamase. SPS-1 antibiotic_resistance ARO:3006997 SPS-1 ARO:3006997 SPS-1 SPU-1 is a SPU beta-lactamase. SPU-1 antibiotic_resistance ARO:3006998 SPU-1 ARO:3006998 SPU-1 SST-1 is a SST beta-lactamase. SST-1 antibiotic_resistance ARO:3006999 SST-1 ARO:3006999 SST-1 STA-1 is a STA beta-lactamase. STA-1 antibiotic_resistance ARO:3007000 STA-1 ARO:3007000 STA-1 TER-1 is a TER beta-lactamase. TER-1 antibiotic_resistance ARO:3007001 TER-1 ARO:3007001 TER-1 TTU-1 is a TTU beta-lactamase. TTU-1 antibiotic_resistance ARO:3007002 TTU-1 ARO:3007002 TTU-1 VHH-1 is a VHH beta-lactamase. VHH-1 antibiotic_resistance ARO:3007003 VHH-1 ARO:3007003 VHH-1 VHW-1 is a VHW beta-lactamase. VHW-1 antibiotic_resistance ARO:3007004 VHW-1 ARO:3007004 VHW-1 YEM-1 is a YEM beta-lactamase. YEM-1 antibiotic_resistance ARO:3007005 YEM-1 ARO:3007005 YEM-1 ZOG-1 is a ZOG beta-lactamase. ZOG-1 antibiotic_resistance ARO:3007006 ZOG-1 ARO:3007006 ZOG-1 TER-2 is a TER beta-lactamase. TER-2 antibiotic_resistance ARO:3007007 TER-2 ARO:3007007 TER-2 A class of serine beta-lactamase inhibitors. antibiotic_resistance ARO:3007008 diazabicyclooctane ARO:3007008 An experimental diazabicyclooctane beta-lactamase inhibitor that contains a fluorine atom in place of the carboxamide. PubChem:153516440 antibiotic_resistance ARO:3007009 ANT3310 ARO:3007009 An experimental diazabicyclooctane beta-lactamase inhibitor that contains a fluorine atom in place of the carboxamide. PMID:33306385 NorC is a multidrug efflux pump in Staphylococcus aureus that confers resistance to fluoroquinolones and other structurally unrelated antibiotics like tetracycline. It shares 61% similarity with NorB, and is a structural homolog of Blt of Bacillus subtilis. Like NorA and NorB, NorC is regulated by mgrA, also known as NorR. norC antibiotic_resistance ARO:3007010 norC ARO:3007010 NorC is a multidrug efflux pump in Staphylococcus aureus that confers resistance to fluoroquinolones and other structurally unrelated antibiotics like tetracycline. It shares 61% similarity with NorB, and is a structural homolog of Blt of Bacillus subtilis. Like NorA and NorB, NorC is regulated by mgrA, also known as NorR. PMID:16495280 PMID:23929475 norC mdeA is a multidrug efflux pump that confers resistance in varying degrees to several unrelated antibiotics, including kanamycin, tetracycline, ampicillin, oxacillin, ciprofloxacin, nalidixic acid, acriflavine, and ethidium bromide. mdeA antibiotic_resistance ARO:3007011 mdeA ARO:3007011 mdeA is a multidrug efflux pump that confers resistance in varying degrees to several unrelated antibiotics, including kanamycin, tetracycline, ampicillin, oxacillin, ciprofloxacin, nalidixic acid, acriflavine, and ethidium bromide. PMID:23462018 mdeA sepA is a multidrug efflux pump that confers resistance to disinfecting agents and dyes. sepA antibiotic_resistance ARO:3007012 sepA ARO:3007012 sepA is a multidrug efflux pump that confers resistance to disinfecting agents and dyes. PMID:12499635 sepA sdrM encodes an efflux pump that confers resistance to norfloxacin and ethidium bromide, making this a multidrug resistance gene. SA1972 sdrM antibiotic_resistance ARO:3007013 sdrM ARO:3007013 sdrM encodes an efflux pump that confers resistance to norfloxacin and ethidium bromide, making this a multidrug resistance gene. PMID:16508166 sdrM qacJ is a small multidrug resistance (SMR) efflux pump that confers resistance to quaternary ammonium compounds. qacJ antibiotic_resistance ARO:3007014 qacJ ARO:3007014 qacJ is a small multidrug resistance (SMR) efflux pump that confers resistance to quaternary ammonium compounds. PMID:14506007 qacJ qacG is a small multidrug resistance efflux pump that confers resistance to benzalkonium chloride and ethidium bromide. qacG antibiotic_resistance ARO:3007015 qacG ARO:3007015 qacG is a small multidrug resistance efflux pump that confers resistance to benzalkonium chloride and ethidium bromide. PMID:10196743 qacG SHD beta-lactamases are class B1 beta-lactamases found in Shewanella denitrificans. antibiotic_resistance ARO:3007016 SHD beta-lactamase ARO:3007016 SHD-1 is a SHD beta-lactamase. SHD-1 antibiotic_resistance ARO:3007017 SHD-1 ARO:3007017 SHD-1 is a SHD beta-lactamase. PMID:29020980 SHD-1 A CARD-specific abbreviation for AMR gene names associated with Antibiotic Resistance Ontology terms, often not based on the literature. This is used for programmatic and compatibility purposes and is not ontologically relevant. Each ontology term with an associated AMR detection model has a CARD Short Name that appears in CARD data files and output generated by RGI. If the original gene name is less than 15 characters, the CARD short name is identical; if the gene name is greater than 15 characters, the CARD Short Name has been abbreviated by CARD curators specifically to identify the proper gene or protein name. All CARD Short Names are unique and have whitespace characters replaced by underscore characters. The convention for pathogen names is capitalized first letter of the genus followed by the lowercase first three letters of the species name. The antibiotic abbreviations are from https://journals.asm.org/journal/aac/abbreviations plus some custom abbreviations by the CARD curators. Simple CARD Short Names often do not involve either, e.g. CTX-M-15, but where applicable the CARD Short Names follow pathogen_gene or pathogen_gene_drug. The full lists of abbreviations can be found in the CARD Downloads: https://card.mcmaster.ca/latest/data. antibiotic_resistance ARO:3007018 CARD Short Name ARO:3007018 FexB is a plasmid-encoded exporter gene which confers resistance to florfenicol. Originally identified in Enterococcus sp. isolated from swine by Liu et al. 2012. fexB antibiotic_resistance ARO:3007019 fexB ARO:3007019 FexB is a plasmid-encoded exporter gene which confers resistance to florfenicol. Originally identified in Enterococcus sp. isolated from swine by Liu et al. 2012. PMID:22096043 fexB PFM-4 (BioF) is a class B2 metallo-beta-lactamase first identified in Pseudomonas. It belongs to the PFM-like beta-lactamase gene family. It confers resistance to carbapenems and some cephalosporins. BioF PFM-4 antibiotic_resistance ARO:3007021 PFM-4 ARO:3007021 PFM-4 (BioF) is a class B2 metallo-beta-lactamase first identified in Pseudomonas. It belongs to the PFM-like beta-lactamase gene family. It confers resistance to carbapenems and some cephalosporins. PMID:34725905 PFM-4 Prulifloxacin is a 6-fluoroquinolone antibiotic with a C-2 sulfur atom. It is hydrolyzed by esterases to produce the active compound Ulifloxacin. The active compound has broad spectrum activity against most Gram-negative bacteria. Prulifloxacin displays strong bactericidal activity against Pseudomonas aeruginosa biofilms and persister cells. CAS:123447-62-1 ChEBI:32071 ChEMBL:CHEMBL422648 PubChem:65947 antibiotic_resistance ARO:3007022 Prulifloxacin ARO:3007022 Prulifloxacin is a 6-fluoroquinolone antibiotic with a C-2 sulfur atom. It is hydrolyzed by esterases to produce the active compound Ulifloxacin. The active compound has broad spectrum activity against most Gram-negative bacteria. Prulifloxacin displays strong bactericidal activity against Pseudomonas aeruginosa biofilms and persister cells. PMID:1667252 PMID:34905092 PMID:9531524 NDM-33 confers resistance to all beta-lactam antibiotics except aztreonam. It was first identified in an E. coli strain isolated from hospital sewage. It differs from NDM-5 by a single amino acid substitution (A72T). NDM-33 antibiotic_resistance ARO:3007023 NDM-33 ARO:3007023 NDM-33 confers resistance to all beta-lactam antibiotics except aztreonam. It was first identified in an E. coli strain isolated from hospital sewage. It differs from NDM-5 by a single amino acid substitution (A72T). PMID:34643418 NDM-33 Lascufloxacin is a fluoroquinolone antibiotic. PubChem:71528768 antibiotic_resistance ARO:3007024 Lascufloxacin ARO:3007024 Lascufloxacin is a fluoroquinolone antibiotic. PMID:28320717 Sarecycline is a tetracycline derivative. ChEBI:201449 ChEMBL:CHEMBL2364632 PubChem:54681908 antibiotic_resistance ARO:3007025 Sarecycline ARO:3007025 Sarecycline is a tetracycline derivative. PMID:30397052 salB is a ABC-F subfamily protein gene that confers resistance to lincosamides and class A streptogramins. sal(B) salB antibiotic_resistance ARO:3007026 salB ARO:3007026 salB is a ABC-F subfamily protein gene that confers resistance to lincosamides and class A streptogramins. PMID:35137182 salB salC is a ABC-F subfamily protein gene that confers resistance to lincosamides and class A streptogramins. sal(C) salC antibiotic_resistance ARO:3007027 salC ARO:3007027 salC is a ABC-F subfamily protein gene that confers resistance to lincosamides and class A streptogramins. PMID:35137182 salC salD is a ABC-F subfamily protein gene that confers resistance to lincosamides and class A streptogramins. salD antibiotic_resistance ARO:3007028 salD ARO:3007028 salD is a ABC-F subfamily protein gene that confers resistance to lincosamides and class A streptogramins. PMID:35137182 salD salE is a ABC-F subfamily protein gene that confers resistance to lincosamides and class A streptogramins. sal(E) salE antibiotic_resistance ARO:3007029 salE ARO:3007029 salE is a ABC-F subfamily protein gene that confers resistance to lincosamides and class A streptogramins. PMID:35137182 salE Sal proteins are a part of the ABC-F proteins, expressed in staphylococci that confer resistance to group A streptogramin, lincosamide, and pleuromutilin antibiotics through ribosomal protection. antibiotic_resistance ARO:3007030 sal-type ABC-F protein ARO:3007030 Sal proteins are a part of the ABC-F proteins, expressed in staphylococci that confer resistance to group A streptogramin, lincosamide, and pleuromutilin antibiotics through ribosomal protection. PMID:35137182 A serine beta-lactamase inhibitor that prevents the degradation of imipenem in the body. ChEMBL:CHEMBL3301605 PubChem:44129647 antibiotic_resistance ARO:3007031 relebactam ARO:3007031 Erm(50) is an Erm ribosomal RNA methyltransferase. Erm(50) antibiotic_resistance ARO:3007032 Erm(50) ARO:3007032 Erm(50) is an Erm ribosomal RNA methyltransferase. PMID:31844016 Erm(50) Erm(51) is an Erm ribosomal RNA methyltransferase. Erm(51) antibiotic_resistance ARO:3007033 Erm(51) ARO:3007033 Erm(51) is an Erm ribosomal RNA methyltransferase. PMID:32291839 Erm(51) Tetracenomycin antibiotics are aromatic polyketides that inhibit translation by binding to the large ribosomal subunit within the polypeptide exit tunnel. antibiotic_resistance ARO:3007034 tetracenomycin antibiotic ARO:3007034 Tetracenomycin C is a tetracenomycin antibiotic, a methyl ester and a tertiary alpha-hydroxy ketone. CAS:71135-22-3 ChEBI:9470 PubChem:73632 antibiotic_resistance ARO:3007035 tetracenomycin C ARO:3007035 Tetracenomycin C is a tetracenomycin antibiotic, a methyl ester and a tertiary alpha-hydroxy ketone. PMID:11851469 Tetracenomycin X is a tetracenomycin antibiotic, a methyl ester and a tertiary alpha-hydroxy ketone. CAS:121245-07-6 ChEBI:32209 PubChem:129395 antibiotic_resistance ARO:3007036 tetracenomycin X ARO:3007036 Tetracenomycin X is a tetracenomycin antibiotic, a methyl ester and a tertiary alpha-hydroxy ketone. PMID:32601485 Tetracenomycin A2 is a tetracenomycin antibiotic, a methyl ester and a tertiary alpha-hydroxy ketone. CAS:82277-62-1 ChEBI:32197 PubChem:134024 antibiotic_resistance ARO:3007037 tetracenomycin A2 ARO:3007037 Chlorhexidine is a disinfectant and antiseptic that is used for skin disinfection, including mouthwashes (chlorhexidine gluconate). CAS:55-56-1 ChEBI:3614 ChEMBL:CHEMBL790 PubChem:9552079 chlorhexidine acetate chlorhexidine digluconate chlorhexidine gluconate antibiotic_resistance ARO:3007039 chlorhexidine ARO:3007039 A combination therapy for multidrug resistant pathogens consisting of two cephalosporin antibiotics (cefotaxime and ceftiofur) with two beta-lactamase inhibitors (tazobactam and clavulanate) encapsulated in a nanoparticle. They were shown to have efficient antimicrobial activity against multidrug resistant extended-spectrum beta-lactamase producing Enterobacteriaceae. antibiotic_resistance ARO:3007040 cefotaxime-ceftiofur-tazobactam-clavulanate ARO:3007040 A combination therapy for multidrug resistant pathogens consisting of two cephalosporin antibiotics (cefotaxime and ceftiofur) with two beta-lactamase inhibitors (tazobactam and clavulanate) encapsulated in a nanoparticle. They were shown to have efficient antimicrobial activity against multidrug resistant extended-spectrum beta-lactamase producing Enterobacteriaceae. PMID:34920071 Erm(52) is an Erm ribosomal RNA methyltransferase. Erm(52) antibiotic_resistance ARO:3007041 Erm(52) ARO:3007041 Erm(52) is an Erm ribosomal RNA methyltransferase. PMID:33956520 Erm(52) msr(G) is a part of the msr subfamily of ABC-F ribosomal protection proteins. msr(G) msrG antibiotic_resistance ARO:3007042 msr(G) ARO:3007042 msr(G) is a part of the msr subfamily of ABC-F ribosomal protection proteins. PMID:33118027 msr(G) msr(I) is part of the msr subfamily of ABC-F ribosomal protection proteins. msr(I) msrI antibiotic_resistance ARO:3007043 msr(I) ARO:3007043 msr(I) mef(F) is an mef efflux pump protein. mef(F) mefF antibiotic_resistance ARO:3007044 mef(F) ARO:3007044 mef(F) is an mef efflux pump protein. PMID:33118027 mef(F) Enrofloxacin is a broad-spectrum fluoroquinolone antibiotic. It is used in veterinary medicine predominately for dogs and cats but is sometimes used for other animals. CAS:93106-60-6 ChEBI:35720 ChEMBL:CHEMBL15511 PubChem:71188 antibiotic_resistance ARO:3007045 enrofloxacin ARO:3007045 Enrofloxacin is a broad-spectrum fluoroquinolone antibiotic. It is used in veterinary medicine predominately for dogs and cats but is sometimes used for other animals. PMID:9278889 Marbofloxacin is a broad-spectrum fluoroquinolone antibiotic. It is used in veterinary medicine predominately for dogs and cats. CAS:115550-35-1 ChEBI:132230 ChEMBL:CHEMBL478120 PubChem:60651 antibiotic_resistance ARO:3007046 marbofloxacin ARO:3007046 mef(H) is an mef efflux pump protein. mef(H) mefH antibiotic_resistance ARO:3007047 mef(H) ARO:3007047 mef(H) is an mef efflux pump protein. PMID:33956520 mef(H) Xeruborbactam is an experimental cyclic boronate ultrabroad-spectrum beta-lactamase inhibitor, with potent activity against both serine beta-lactamases and metallo-beta-lactamases. ChEMBL:CHEMBL4633785 PubChem:140830474 QPX7728 antibiotic_resistance ARO:3007048 Xeruborbactam ARO:3007048 Xeruborbactam is an experimental cyclic boronate ultrabroad-spectrum beta-lactamase inhibitor, with potent activity against both serine beta-lactamases and metallo-beta-lactamases. PMID:34902261 mef(J) is an mef efflux pump protein. mef(J) mefJ antibiotic_resistance ARO:3007049 mef(J) ARO:3007049 mef(J) mreA is a macrolide efflux pump. mreA antibiotic_resistance ARO:3007050 mreA ARO:3007050 mreA is a macrolide efflux pump. PMID:9420045 mreA Rifampicin inhibits transcription by binding the beta subunit of RNA polymerase. Helicobacter pylori mutations associated with rifampicin resistance typically occur in the rifampicin resistance determining region of rpoB between codons 525 and 586. Hpyl_rpoB_RIF antibiotic_resistance ARO:3007051 Helicobacter pylori rpoB mutation conferring resistance to rifampicin ARO:3007051 Rifampicin inhibits transcription by binding the beta subunit of RNA polymerase. Helicobacter pylori mutations associated with rifampicin resistance typically occur in the rifampicin resistance determining region of rpoB between codons 525 and 586. PMID:10348780 PMID:10817737 PMID:17350989 PMID:30774400 PMID:30815255 Hpyl_rpoB_RIF Point mutations in the quinolone resistance-determining regions of Helicobacter pylori observed to confer resistance to fluoroquinolone antibiotics. Hpyl_gyrA_FLO antibiotic_resistance ARO:3007052 Helicobacter pylori gyrA conferring resistance to fluoroquinolones ARO:3007052 Point mutations in the quinolone resistance-determining regions of Helicobacter pylori observed to confer resistance to fluoroquinolone antibiotics. PMID:21762270 PMID:22064536 PMID:22515359 PMID:25003707 PMID:25499186 PMID:27809767 PMID:27906990 PMID:28018334 PMID:30774400 PMID:32471292 PMID:38089809 Hpyl_gyrA_FLO Point mutations in Helicobacter pylori conferring resistance to fluoroquinolone antibiotics. Hpyl_gyrB_FLO antibiotic_resistance ARO:3007053 Helicobacter pylori gyrB conferring resistance to fluoroquinolones ARO:3007053 Point mutations in Helicobacter pylori conferring resistance to fluoroquinolone antibiotics. PMID:21793912 PMID:22221614 PMID:25003707 PMID:30774400 Hpyl_gyrB_FLO The rdxA gene in Helicobacter pylori encodes an NADPH nitroreductase. Mutations in this gene are associated with metronidazole resistance. Hpyl_rdxA_MTZ antibiotic_resistance ARO:3007055 Helicobacter pylori rdxA mutation conferring resistance to metronidazole ARO:3007055 The rdxA gene in Helicobacter pylori encodes an NADPH nitroreductase. Mutations in this gene are associated with metronidazole resistance. PMID:10681326 PMID:21801504 PMID:24827414 PMID:27809767 PMID:30621024 PMID:31744181 PMID:32099422 PMID:33593015 PMID:37485536 PMID:9622362 Hpyl_rdxA_MTZ Inactivation of the oxygen-insensitive NADPH nitroreductases in Helicobacter pylori play a role in metronidazole resistance. antibiotic_resistance ARO:3007056 Antibiotic resistant Helicobacter pylori nitroreductase ARO:3007056 Inactivation of the oxygen-insensitive NADPH nitroreductases in Helicobacter pylori play a role in metronidazole resistance. PMID:11489869 Point mutations in Helicobacter pylori pbp3 observed to confer resistance to amoxicillin. Hpyl_pbp3_AMX antibiotic_resistance ARO:3007057 Helicobacter pylori pbp3 conferring resistance to amoxicillin ARO:3007057 Point mutations in Helicobacter pylori pbp3 observed to confer resistance to amoxicillin. PMID:18276599 PMID:31801839 Hpyl_pbp3_AMX Point mutations in Helicobacter pylori pbp2 observed to confer resistance to amoxicillin. Hpyl_pbp2_AMX antibiotic_resistance ARO:3007058 Helicobacter pylori pbp2 mutants conferring resistance to amoxicillin ARO:3007058 Point mutations in Helicobacter pylori pbp2 observed to confer resistance to amoxicillin. PMID:18276599 PMID:31801839 Hpyl_pbp2_AMX FrxA encodes an NADH-flavin oxidoreductase in Helicobacter pylori. Mutations in this gene confer resistance to nitrofuran antibiotics and metronidazole. Hpyl_fxrA_MTZ antibiotic_resistance ARO:3007059 Helicobacter pylori frxA mutation conferring resistance to metronidazole ARO:3007059 FrxA encodes an NADH-flavin oxidoreductase in Helicobacter pylori. Mutations in this gene confer resistance to nitrofuran antibiotics and metronidazole. PMID:21801504 PMID:25132107 PMID:27809767 PMID:30621024 PMID:32099422 PMID:33593015 Hpyl_fxrA_MTZ Point mutations in Helicobacter pylori pbp1 observed to confer resistance to amoxicillin. Hpyl_pbp1_AMX antibiotic_resistance ARO:3007060 Helicobacter pylori pbp1 mutants conferring resistance to amoxicillin ARO:3007060 Point mutations in Helicobacter pylori pbp1 observed to confer resistance to amoxicillin. PMID:17951983 PMID:18192681 PMID:31801839 PMID:32545318 PMID:32708761 PMID:35114945 PMID:37485536 Hpyl_pbp1_AMX Hp1165 is a homolog of the Clostridium perfringes tetP gene and is part of the MFS efflux family but is not considered a true tetracycline resistance gene. Hp1165 confers low level resistance to tetracycline, however cessation of antibiotic treatment results in the host cell reverting to susceptibility. antibiotic_resistance ARO:3007061 hp1165 ARO:3007061 Hp1165 is a homolog of the Clostridium perfringes tetP gene and is part of the MFS efflux family but is not considered a true tetracycline resistance gene. Hp1165 confers low level resistance to tetracycline, however cessation of antibiotic treatment results in the host cell reverting to susceptibility. PMID:16482431 VAM-1 is a subclass B1 metallo-beta-lactamase, conferring resistance to beta-lactam antibiotics such as carbapenems and cephalosporins. VAM-1 VAM1 antibiotic_resistance ARO:3007062 VAM-1 ARO:3007062 VAM-1 is a subclass B1 metallo-beta-lactamase, conferring resistance to beta-lactam antibiotics such as carbapenems and cephalosporins. PMID:34424042 VAM-1 Cilastatin is often prescribed with imipenem as a beta-lactam potentiator. Cilastatin inhibits enzymatic renal dehydropeptidase, which hydrolyzes imipenem, thereby preventing the metabolism of imipenem in vivo and maintaining longer antibiotic exposure and effect. CAS:82009-34-5 ChEBI:3697 ChEMBL:CHEMBL766 PubChem:6435415 antibiotic_resistance ARO:3007063 cilastatin ARO:3007063 VAM beta-lactamases are class B1 beta-lactamases found in Vibrio alginolyticus. antibiotic_resistance ARO:3007065 VAM beta-lactamase ARO:3007065 Milligrams per Litre (mg/L). antibiotic_resistance ARO:3007066 mg/L ARO:3007066 Millimeters (mm). antibiotic_resistance ARO:3007067 mm ARO:3007067 ABC-F subfamily ATP-binding cassette ribosomal protection proteins of unknown, unclear or miscellaneous classification which nevertheless confer resistance to antibiotics through ribosomal protection and not through antibiotic efflux. These proteins should be further reviewed to elucidate associated genes, their function, origin and classification. antibiotic_resistance ARO:3007068 Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins ARO:3007068 A thiol transferase isolated in Staphylococcus aureus that leads to resistance of fosfomycin. FosY antibiotic_resistance ARO:3007069 FosY ARO:3007069 A thiol transferase isolated in Staphylococcus aureus that leads to resistance of fosfomycin. PMID:35332834 FosY An MCR-1-type colistin resistance gene variant, first described in a multi-drug-resistant Escherichia coli isolate recovered from a urinary tract infection, and co-occurring with the carbapenemase NDM-5. MCR-1.33 antibiotic_resistance ARO:3007070 MCR-1.33 ARO:3007070 An MCR-1-type colistin resistance gene variant, first described in a multi-drug-resistant Escherichia coli isolate recovered from a urinary tract infection, and co-occurring with the carbapenemase NDM-5. PMID:35411158 MCR-1.33 An antibiotic-adjuvant admixture of the beta-lactam antibiotic ceftazidime and the non-beta-lactam beta-lactamase inhibitor avibactam. CAS:1393723-27-7 ChEBI:85989 PubChem:77050660 antibiotic_resistance ARO:3007072 ceftazidime-avibactam ARO:3007072 An antibiotic-adjuvant admixture of the beta-lactam antibiotic ceftazidime and the non-beta-lactam beta-lactamase inhibitor avibactam. PMID:23371303 PMID:29671219 Point mutations that occur within the Bacillus subtilis rpoB gene resulting in resistance to rifampin. Bsub_rpoB_RIF antibiotic_resistance ARO:3007073 Bacillus subtilis rpoB mutants conferring resistance to rifampin ARO:3007073 Point mutations that occur within the Bacillus subtilis rpoB gene resulting in resistance to rifampin. PMID:11101662 PMID:12169622 PMID:7657605 Bsub_rpoB_RIF Capreomycin family of phosphotransferases confer resistance to capreomycin antibiotics. antibiotic_resistance ARO:3007074 capreomycin phosphotransferase ARO:3007074 Capreomycin family of phosphotransferases confer resistance to capreomycin antibiotics. PMID:6163840 cph is a phosphotransferase that confers resistance to capreomycin. cph antibiotic_resistance ARO:3007075 cph ARO:3007075 cph is a phosphotransferase that confers resistance to capreomycin. PMID:34994196 PMID:6163840 cph A fungal secondary metabolite which inhibits the action of New Delhi metallo-beta-lactamase 1. ChEBI:209829 PubChem:146683214 antibiotic_resistance ARO:3007076 emerione A ARO:3007076 A fungal secondary metabolite which inhibits the action of New Delhi metallo-beta-lactamase 1. PMID:35017068 Molecules and compounds that decrease resistance by inhibiting the action of the MrsA efflux pump. antibiotic_resistance ARO:3007077 inhibitors of MsrA efflux pump ARO:3007077 Luteolin is a flavonoid produced by a variety of plants that features a wide range of biological effects. It has been shown to inhibit the action of the MsrA drug efflux pump. CAS:491-70-3 ChEBI:15864 ChEMBL:CHEMBL151 PubChem:5280445 3',4',5,7-Tetrahydroxyflavone Digitoflavone Luteolol antibiotic_resistance ARO:3007078 Luteolin ARO:3007078 Luteolin is a flavonoid produced by a variety of plants that features a wide range of biological effects. It has been shown to inhibit the action of the MsrA drug efflux pump. PMID:18991571 PMID:35012652 Pellitorine is a metabolite produced mainly in members of the Zanthoxylum, Tetradium, and Piper genera. It has been shown to inhibit the action of the MsrA drug efflux pump. CAS:18836-52-7 ChEBI:69686 ChEMBL:CHEMBL271242 PubChem:5318516 Pellitorin antibiotic_resistance ARO:3007079 Pellitorine ARO:3007079 Pellitorine is a metabolite produced mainly in members of the Zanthoxylum, Tetradium, and Piper genera. It has been shown to inhibit the action of the MsrA drug efflux pump. PMID:32449250 Piperic acid is a compound produced by members of the Piper genus. It has been shown to inhibit the action of the MsrA drug efflux pump. CAS:136-72-1 ChEBI:37316 ChEMBL:CHEMBL332122 PubChem:5370536 Piperonic acid antibiotic_resistance ARO:3007080 Piperic acid ARO:3007080 Piperic acid is a compound produced by members of the Piper genus. It has been shown to inhibit the action of the MsrA drug efflux pump. PMID:32449250 Tetraydropiperine is a derivative of piperine produced by members of the Piper genus. It has been shown to inhibit the action of the MsrA drug efflux pump. ChEBI:184110 ChEMBL:CHEMBL332479 PubChem:581676 Cosmoperine Tetrahydropiperin antibiotic_resistance ARO:3007081 Tetrahydropiperine ARO:3007081 Tetraydropiperine is a derivative of piperine produced by members of the Piper genus. It has been shown to inhibit the action of the MsrA drug efflux pump. PMID:32449250 Sesamin is a compound isolated from sesame oil and bark from plants in the Zanthoxylum genus. It has been shown to inhibit the action of the MsrA drug efflux pump. CAS:607-80-7 ChEBI:66470 ChEMBL:CHEMBL252915 PubChem:72307 Asarinin Episesamin Fagarol Fsesamin Pseudocubebin Sezamin antibiotic_resistance ARO:3007082 Sesamin ARO:3007082 Sesamin is a compound isolated from sesame oil and bark from plants in the Zanthoxylum genus. It has been shown to inhibit the action of the MsrA drug efflux pump. PMID:32449250 Biapenem is a broad spectrum injectable antibiotic belonging to the carbapenem subgroup of beta-lactams. CAS:120410-24-4 ChEBI:3089 ChEMBL:CHEMBL285347 PubChem:71339 Biapenern Bipenem Omegacin antibiotic_resistance ARO:3007083 biapenem ARO:3007083 Biapenem is a broad spectrum injectable antibiotic belonging to the carbapenem subgroup of beta-lactams. PMID:12381221 PMID:8031067 PRC beta-lactamases are class C beta-lactamases. antibiotic_resistance ARO:3007084 PRC beta-lactamase ARO:3007084 PRC beta-lactamases are class C beta-lactamases. PMID:34975778 PRC-1 is a beta-lactamase that confers resistance to certain cephalosporins and penicillins. PRC-1 antibiotic_resistance ARO:3007085 PRC-1 ARO:3007085 PRC-1 is a beta-lactamase that confers resistance to certain cephalosporins and penicillins. PMID:34975778 PRC-1 Epinecidin-1 is a peptide antibiotic derived from Epinephelus coioides with broad spectrum activity against a range or Gram positive and Gram negative bacteria. PubChem:49769423 antibiotic_resistance ARO:3007086 epinecidin-1 ARO:3007086 Epinecidin-1 is a peptide antibiotic derived from Epinephelus coioides with broad spectrum activity against a range or Gram positive and Gram negative bacteria. PMID:17570764 KPC-90 is a KPC beta-lactamase. KPC-90 antibiotic_resistance ARO:3007087 KPC-90 ARO:3007087 KPC-90 is a KPC beta-lactamase. PMID:35019766 KPC-90 A peptidomimetic antibiotic with specific, potent action against members of the Pseudomonas genus. Murepavadin disrupts lipopolysaccharide biosynthesis by binding to lypopolysaccharide transport protein D. ChEMBL:CHEMBL3946483 PubChem:91824766 POL7080 antibiotic_resistance ARO:3007088 murepavadin ARO:3007088 A peptidomimetic antibiotic with specific, potent action against members of the Pseudomonas genus. Murepavadin disrupts lipopolysaccharide biosynthesis by binding to lypopolysaccharide transport protein D. PMID:20167788 PMID:33367642 KPC-83 is a KPC beta-lactamase. KPC-83 antibiotic_resistance ARO:3007089 KPC-83 ARO:3007089 KPC-83 Albendazole is a compound used in the treatment of parasitic worm infestations. It has been shown to exhibit antibiotic activity against Escherichia coli by inhibiting MurA (MurZ), thereby disrupting cell wall synthesis. CAS:54965-21-8 ChEBI:16664 ChEMBL:CHEMBL1483 PubChem:2082 Albendazol Albendazolum Albenza Bilutac Eskazole Proftril Valbazen Zentel antibiotic_resistance ARO:3007090 albendazole ARO:3007090 Albendazole is a compound used in the treatment of parasitic worm infestations. It has been shown to exhibit antibiotic activity against Escherichia coli by inhibiting MurA (MurZ), thereby disrupting cell wall synthesis. PMID:35453279 Diflunisal is a salicylic acid derivative and aspirin analogue typically used as a nonsteroidal anti-inflammatory drug. It has been shown to exhibit antibiotic activity against Escherichia coli by inhibiting MurA (MurZ), thereby disrupting cell wall synthesis. CAS:22494-42-4 ChEBI:39669 ChEMBL:CHEMBL898 PubChem:3059 Adomal Dolobid Dolobis Flovacil Fluniget Fluodonil Flustar antibiotic_resistance ARO:3007091 diflunisal ARO:3007091 Diflunisal is a salicylic acid derivative and aspirin analogue typically used as a nonsteroidal anti-inflammatory drug. It has been shown to exhibit antibiotic activity against Escherichia coli by inhibiting MurA (MurZ), thereby disrupting cell wall synthesis. PMID:35453279 Gepotidacin is a triazaacenaphthylene bacterial type II topoisomerase inhibitor used experimentally. It has been in phase III of clinical trials since 2019 for the treatment of gonorrhea, however gepotidacin has demonstrated antibiotic activity against a variety of bacteria. ChEMBL:CHEMBL3317856 PubChem:25101874 antibiotic_resistance ARO:3007092 gepotidacin ARO:3007092 Gepotidacin is a triazaacenaphthylene bacterial type II topoisomerase inhibitor used experimentally. It has been in phase III of clinical trials since 2019 for the treatment of gonorrhea, however gepotidacin has demonstrated antibiotic activity against a variety of bacteria. PMID:26729499 Klebsidin is a peptide antibiotic derived from Klebsiella pneumoniae that exhibits activity against members of the Enterobacteriaceae family of Gram-negative bacteria, including Escherichia and Salmonella species. Klebsidin acts by accumulating in the target cell and inhibiting RNA polymerase. ChEBI:219023 PubChem:146684527 antibiotic_resistance ARO:3007093 klebsidin ARO:3007093 Klebsidin is a peptide antibiotic derived from Klebsiella pneumoniae that exhibits activity against members of the Enterobacteriaceae family of Gram-negative bacteria, including Escherichia and Salmonella species. Klebsidin acts by accumulating in the target cell and inhibiting RNA polymerase. PMID:35315272 Fisetin is a flavonoid produced mainly by plants in the Eudicotidae clade. It exhibits a range of biological activities such as anti-inflammatory and antioxidant properties, and fisetin has been shown to inhibit the action of metallo-beta-lactamases. CAS:528-48-3 ChEBI:42567 ChEMBL:CHEMBL31574 PubChem:5281614 Cotinin Fustel Viset antibiotic_resistance ARO:3007094 fisetin ARO:3007094 Fisetin is a flavonoid produced mainly by plants in the Eudicotidae clade. It exhibits a range of biological activities such as anti-inflammatory and antioxidant properties, and fisetin has been shown to inhibit the action of metallo-beta-lactamases. PMID:35101651 Risedronate is a bisphosphonate used as an oral medication to treat osteoperosis and Paget's disease of bone. It has been shown to inhibit the action of New Delhi metallo-beta-lactamase-1. CAS:105462-24-6 ChEBI:8869 ChEMBL:CHEMBL923 PubChem:5245 Actonel Atelvia Benet Risedronic acid antibiotic_resistance ARO:3007095 risedronate ARO:3007095 Risedronate is a bisphosphonate used as an oral medication to treat osteoperosis and Paget's disease of bone. It has been shown to inhibit the action of New Delhi metallo-beta-lactamase-1. PMID:35209073 Methotrexate is an antifolate chemotherapeutic and immune suppressant used to treat a wide variety of cancers and autoimmune diseases. It has been shown to inhibit the action of New Delhi metallo-beta-lactamase-1. CAS:59-05-2 ChEBI:44185 ChEMBL:CHEMBL34259 PubChem:126941 Otrexup Rheumatrex Trexall antibiotic_resistance ARO:3007096 methotrexate ARO:3007096 Methotrexate is an antifolate chemotherapeutic and immune suppressant used to treat a wide variety of cancers and autoimmune diseases. It has been shown to inhibit the action of New Delhi metallo-beta-lactamase-1. PMID:35209073 FosM1 is a thiol transferase discovered in human gut microflora that leads to the resistance of fosfomycin. FosM1 antibiotic_resistance ARO:3007097 FosM1 ARO:3007097 FosM1 is a thiol transferase discovered in human gut microflora that leads to the resistance of fosfomycin. PMID:33199384 FosM1 FosM2 is a thiol transferase discovered in human gut microflora that leads to the resistance of fosfomycin. FosM2 antibiotic_resistance ARO:3007098 FosM2 ARO:3007098 FosM2 is a thiol transferase discovered in human gut microflora that leads to the resistance of fosfomycin. PMID:33199384 FosM2 FosM3 is a thiol transferase discovered in human gut microflora that leads to the resistance of fosfomycin. FosM3 antibiotic_resistance ARO:3007099 FosM3 ARO:3007099 FosM3 is a thiol transferase discovered in human gut microflora that leads to the resistance of fosfomycin. PMID:33199384 FosM3 Class A Bacillus cereus Bc beta-lactamases are enzymes that break down beta-lactam antibiotics, particularly penicillins. antibiotic_resistance ARO:3007100 class A Bacillus cereus Bc beta-lactamase ARO:3007100 Class A Bacillus cereus Bc beta-lactamases are enzymes that break down beta-lactam antibiotics, particularly penicillins. PMID:29551437 Bacillus cereus beta-lactamase III is a class A beta-lactamase that breaks down a number of penicillins and cephalosporins in Bacillus cereus. BcIII antibiotic_resistance ARO:3007101 BcIII ARO:3007101 Bacillus cereus beta-lactamase III is a class A beta-lactamase that breaks down a number of penicillins and cephalosporins in Bacillus cereus. PMID:29551437 BcIII KPC-93 is a KPC beta-lactamase. KPC-93 antibiotic_resistance ARO:3007102 KPC-93 ARO:3007102 KPC-93 Nitroimidazole reductases are a group of enzymes that deactivate nitroimidazole antibiotics by reducing their nitro functional group to an amino group. These enzymes are associated with resistance to nitroimidazole derivatives in Bacteroides fragilis but have also been reported in a variety of anaerobic Gram-negative and Gram-positive genera. The minimum inhibitory concentrations for these enzymes vary greatly depending on species, strain, and precise nitroimidazole treatment used. antibiotic_resistance ARO:3007103 nitroimidazole reductase ARO:3007103 Nitroimidazole reductases are a group of enzymes that deactivate nitroimidazole antibiotics by reducing their nitro functional group to an amino group. These enzymes are associated with resistance to nitroimidazole derivatives in Bacteroides fragilis but have also been reported in a variety of anaerobic Gram-negative and Gram-positive genera. The minimum inhibitory concentrations for these enzymes vary greatly depending on species, strain, and precise nitroimidazole treatment used. PMID:10970359 PMID:30316817 nimA is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. nimA antibiotic_resistance ARO:3007104 nimA ARO:3007104 nimA is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. PMID:10970359 PMID:8067736 nimA nimC is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. nimC antibiotic_resistance ARO:3007105 nimC ARO:3007105 nimC is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. PMID:10970359 PMID:7773395 nimC nimD is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. nimD antibiotic_resistance ARO:3007106 nimD ARO:3007106 nimD is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. PMID:10970359 PMID:7773395 nimD nimE is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. nimE antibiotic_resistance ARO:3007107 nimE ARO:3007107 nimE is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. PMID:10970359 PMID:15273153 nimE nimF is a nitroimidazole reductase that shares significant identity with other nim genes which are associated with the deactivation of nitroimidazole antibiotics. nimF antibiotic_resistance ARO:3007108 nimF ARO:3007108 nimF is a nitroimidazole reductase that shares significant identity with other nim genes which are associated with the deactivation of nitroimidazole antibiotics. PMID:15728943 nimF nimG is a nitroimidazole reductase that shares significant identity with other nim genes which are associated with the deactivation of nitroimidazole antibiotics. nimG antibiotic_resistance ARO:3007109 nimG ARO:3007109 nimG is a nitroimidazole reductase that shares significant identity with other nim genes which are associated with the deactivation of nitroimidazole antibiotics. PMID:15190033 nimG nimH is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. nimH antibiotic_resistance ARO:3007110 nimH ARO:3007110 nimH is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. PMID:28535278 nimH nimI is a nitroimidazole reductase discovered in the Prevotella baroniae that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Although not found in Bacteroids fragilis, the source organism of most nim genes, nimI shares significant similarity with other nitroimidazole reductases. nimI is chromosomally encoded in P. baroniae, suggesting that it is intrinsic to this species. nimI antibiotic_resistance ARO:3007111 nimI ARO:3007111 nimI is a nitroimidazole reductase discovered in the Prevotella baroniae that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Although not found in Bacteroids fragilis, the source organism of most nim genes, nimI shares significant similarity with other nitroimidazole reductases. nimI is chromosomally encoded in P. baroniae, suggesting that it is intrinsic to this species. PMID:19805556 nimI nimJ is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. nimJ antibiotic_resistance ARO:3007112 nimJ ARO:3007112 nimJ is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. PMID:23716049 nimJ nimK is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. nimK antibiotic_resistance ARO:3007113 nimK ARO:3007113 nimK is a nitroimidazole reductase mainly found in Bacteroides fragilis that is associated with the deactivation of nitroimidazole antibiotics such as metronidazole. Minimum inhibitory concentrations observed in isolates vary greatly depending on species, strain, and nitroimidazole treatment. PMID:29982676 nimK Ornidazole is a synthetic nitroimidazole derivative mainly used to treat parasitic infections but has also demonstrated antibiotic activity against anaerobic bacteria. CAS:16773-42-5 ChEBI:75176 ChEMBL:CHEMBL1449676 PubChem:28061 antibiotic_resistance ARO:3007114 ornidazole ARO:3007114 Ornidazole is a synthetic nitroimidazole derivative mainly used to treat parasitic infections but has also demonstrated antibiotic activity against anaerobic bacteria. PMID:18220342 PMID:1863621 Antibiotic-induced changes to cell morphology, including shape, volume and surface area, which decrease antibiotic susceptibility. antibiotic_resistance ARO:3007115 modification to cell morphology ARO:3007115 Antibiotic-induced changes to cell morphology, including shape, volume and surface area, which decrease antibiotic susceptibility. PMID:35616332 Changes to cell morphology by activated growth response in the presence of an antibiotic, leading to a decreased surface-to-volume ratio. Such changes decrease antibiotic influx and increase antibiotic dilution in the cell, thereby increasing survivability, particularly in nutrient-poor environments. antibiotic_resistance ARO:3007116 Reduction in surface-to-volume ratio of cell ARO:3007116 Changes to cell morphology by activated growth response in the presence of an antibiotic, leading to a decreased surface-to-volume ratio. Such changes decrease antibiotic influx and increase antibiotic dilution in the cell, thereby increasing survivability, particularly in nutrient-poor environments. PMID:35616332 Subclass B1 Bacteroides xylanisolvens crx beta-lactamases are zinc metallo-beta-lactamases that hydrolyze carbapenems. antibiotic_resistance ARO:3007117 subclass B1 Bacteroides xylanisolvens crx beta-lactamase ARO:3007117 Subclass B1 Bacteroides xylanisolvens crx beta-lactamases are zinc metallo-beta-lactamases that hydrolyze carbapenems. PMID:35296904 crxA is a subclass B1 metallo-betal-lactamase from Bacteroides xylanisolvens that hydrolyzes carbapenems such as imipenem and meropenem. crxA antibiotic_resistance ARO:3007118 crxA ARO:3007118 crxA is a subclass B1 metallo-betal-lactamase from Bacteroides xylanisolvens that hydrolyzes carbapenems such as imipenem and meropenem. PMID:35296904 crxA Tet(O/32/O) is a mosaic tetracycline resistance gene and ribosomal protection protein. tet(O/32/O) antibiotic_resistance ARO:3007119 tet(O/32/O) ARO:3007119 Tet(O/32/O) is a mosaic tetracycline resistance gene and ribosomal protection protein. PMID:11600392 tet(O/32/O) Tet(O/M/O) is a mosaic tetracycline resistance gene and ribosomal protection protein. tet(O/M/O) antibiotic_resistance ARO:3007120 tet(O/M/O) ARO:3007120 Tet(O/M/O) is a mosaic tetracycline resistance gene and ribosomal protection protein. PMID:15470128 tet(O/M/O) Tet(O/W) is a mosaic tetracycline resistance gene and ribosomal protection protein. tet(O/W) antibiotic_resistance ARO:3007121 tet(O/W) ARO:3007121 Tet(O/W) is a mosaic tetracycline resistance gene and ribosomal protection protein. PMID:15184185 tet(O/W) Tet(O/W/32/O) is a mosaic tetracycline resistance gene and ribosomal protection protein. tet(O/W/32/O) antibiotic_resistance ARO:3007122 tet(O/W/32/O) ARO:3007122 Tet(O/W/32/O) is a mosaic tetracycline resistance gene and ribosomal protection protein. PMID:17967912 tet(O/W/32/O) Tet(O/W/O) is a mosaic tetracycline resistance gene and ribosomal protection protein. tet(O/W/O) antibiotic_resistance ARO:3007123 tet(O/W/O) ARO:3007123 Tet(O/W/O) is a mosaic tetracycline resistance gene and ribosomal protection protein. PMID:12839756 tet(O/W/O) Tet(W/32/O) is a mosaic tetracycline resistance gene and ribosomal protection protein. tet(W/32/O) antibiotic_resistance ARO:3007124 tet(W/32/O) ARO:3007124 Tet(W/32/O) is a mosaic tetracycline resistance gene and ribosomal protection protein. PMID:11959557 tet(W/32/O) ROB-11 is a class A beta-lactamase from the blaROB AMR gene family. ROB-11 antibiotic_resistance ARO:3007125 ROB-11 ARO:3007125 ROB-11 ROB-12 is a class A beta-lactamase from the blaROB AMR gene family. ROB-12 antibiotic_resistance ARO:3007126 ROB-12 ARO:3007126 ROB-12 Streptomyces lividans otr(A) is an oxytetracycline resistance ribosomal protection protein found in Streptomyces lividans. otr(A)S.liv tet antibiotic_resistance ARO:3007127 Streptomyces lividans otr(A) ARO:3007127 Streptomyces lividans otr(A) is an oxytetracycline resistance ribosomal protection protein found in Streptomyces lividans. PMID:1510403 otr(A)S.liv Serine beta-lactamase inhibitors are molecules that inhibit the function of Ambler class A, C, and D beta-lactamases, preventing the inactivation of beta-lactam antibiotics by these enzymes. antibiotic_resistance ARO:3007128 serine beta-lactamase inhibitor ARO:3007128 Metallo-beta-lactamase inhibitors are molecules that inhibit the function of Ambler class B (metallo-) beta-lactamases, preventing the inactivation of beta-lactam antibiotics by these enzymes. antibiotic_resistance ARO:3007129 metallo-beta-lactamase inhibitor ARO:3007129 Beta-lactam derived beta-lactamase inhibitors are molecules possessing structural similarity to beta-lactam antibiotics (i.e. beta-lactam ring) that inhibit the function of serine beta-lactamases. antibiotic_resistance ARO:3007130 beta-lactam derived beta-lactamase inhibitor ARO:3007130 A class of serine beta-lactamase inhibitors. antibiotic_resistance ARO:3007131 boronic acid beta-lactamase inhibitor ARO:3007131 Serine beta-lactamase inhibitors with unknown or undefined classification. antibiotic_resistance ARO:3007132 unclassified serine beta-lactamase inhibitor ARO:3007132 A class of metallo-beta-lactamase inhibitors. antibiotic_resistance ARO:3007133 polypyridine metallo-beta-lactamase inhibitor ARO:3007133 A class of metallo-beta-lactamase inhibitors. antibiotic_resistance ARO:3007134 phosphonate metallo-beta-lactamase inhibitor ARO:3007134 A class of metallo-beta-lactamase inhibitors. antibiotic_resistance ARO:3007135 bisthiazolidine metallo-beta-lactamase inhibitor ARO:3007135 Metallo-beta-lactamase inhibitors with unknown or undefined classification. antibiotic_resistance ARO:3007136 unclassified metallo-beta-lactamase inhibitor ARO:3007136 An MCR-10-type colistin resistance gene variant. mcr-10.1 antibiotic_resistance ARO:3007137 mcr-10.1 ARO:3007137 An MCR-10-type colistin resistance gene variant. PMID:35695522 mcr-10.1 S02030 is an experimental metallo-beta-lactamase inhibitor that exhibits activity against MOX-1. PubChem:71519576 1-{(2r)-2-(Dihydroxyboranyl)-2-[(Thiophen-2-Ylacetyl)amino]ethyl}-1h-1,2,3-Triazole-4-Carboxylic Acid antibiotic_resistance ARO:3007138 S02030 ARO:3007138 S02030 is an experimental metallo-beta-lactamase inhibitor that exhibits activity against MOX-1. PMID:34970229 Cordycepin is an experimental nucleoside antibiotic which has been shown to exhibit activity against H. pylori. It is produced by the Cordyceps fungus, which is used in traditional Chinese medicine. CAS:73-03-0 ChEBI:29014 ChEMBL:CHEMBL305686 PubChem:6303 3'-deoxyadenosine cordycepine antibiotic_resistance ARO:3007139 cordycepin ARO:3007139 Cordycepin is an experimental nucleoside antibiotic which has been shown to exhibit activity against H. pylori. It is produced by the Cordyceps fungus, which is used in traditional Chinese medicine. PMID:35191475 Unithiol is an experimental chelating agent that forms complexes with heavy metals. It has been shown to inhibit the action of the metallo-beta-lactamases NDM-1 and VIM-2. CAS:74-61-3 ChEBI:888 ChEMBL:CHEMBL1569746 PubChem:2724039 DMPS antibiotic_resistance ARO:3007140 unithiol ARO:3007140 Unithiol is an experimental chelating agent that forms complexes with heavy metals. It has been shown to inhibit the action of the metallo-beta-lactamases NDM-1 and VIM-2. PMID:35163756 BLI-489 is an experimental beta-lactamase inhibitor that exhibits broad spectrum activity against class A, B, and D carbapenemases. ChEMBL:CHEMBL4297265 PubChem:9972353 antibiotic_resistance ARO:3007141 BLI-489 ARO:3007141 BLI-489 is an experimental beta-lactamase inhibitor that exhibits broad spectrum activity against class A, B, and D carbapenemases. PMID:35165715 Plantacirin A is a short cationic bacteriocin that increases permeability of the bacterial outer membrane, thus enhancing the effect of accompanying antibiotics. It is derived from Lactiplantibacillus plantarum. PlnA antibiotic_resistance ARO:3007142 plantacirin A ARO:3007142 Plantacirin A is a short cationic bacteriocin that increases permeability of the bacterial outer membrane, thus enhancing the effect of accompanying antibiotics. It is derived from Lactiplantibacillus plantarum. PMID:35499329 Sulopenem is a carbapenem derivative in phase III clinical trials (2022) for the treatment of various gram-positive and gram-negative infections. ChEBI:201412 ChEMBL:CHEMBL1908305 PubChem:9950244 antibiotic_resistance ARO:3007143 sulopenem ARO:3007143 Sulopenem is a carbapenem derivative in phase III clinical trials (2022) for the treatment of various gram-positive and gram-negative infections. PMID:35294769 PBT2 is a former Alzheimer's and Huntington's disease candidate drug that has since been shown to increase susceptibility to colistin, polymyxin B, and tetracycline in N. gonorrhoeae. It is thought to inactivate lipooligosaccharide phosphoethanolamine transferase A, resulting in alteration of cell membrane charge. PubChem:10016012 antibiotic_resistance ARO:3007144 PBT2 ARO:3007144 PBT2 is a former Alzheimer's and Huntington's disease candidate drug that has since been shown to increase susceptibility to colistin, polymyxin B, and tetracycline in N. gonorrhoeae. It is thought to inactivate lipooligosaccharide phosphoethanolamine transferase A, resulting in alteration of cell membrane charge. PMID:34450628 An antibiotic-adjuvant admixture of the beta-lactam antibiotic imipenem, beta-lactam potentiator cilastatin, and beta-lactamase inhibitor relebactam. antibiotic_resistance ARO:3007145 imipenem-cilastatin-relebactam ARO:3007145 An antibiotic-adjuvant admixture of the beta-lactam antibiotic imipenem, beta-lactam potentiator cilastatin, and beta-lactamase inhibitor relebactam. PMID:29230684 PMID:33580649 An antibiotic-adjuvant admixture of the beta-lactam antibiotic meropenem and the beta-lactamase inhibitor vaborbactam. PubChem:86298703 Carbavance Vabomere antibiotic_resistance ARO:3007146 meropenem-vaborbactam ARO:3007146 An antibiotic-adjuvant admixture of the beta-lactam antibiotic meropenem and the beta-lactamase inhibitor vaborbactam. PMID:29230684 PMID:29692218 Taniborbactam is a broad-spectrum beta-lactamase inhibitor. As of 2022, it is in phase III clinical trials in combination with cefepime and is the only beta-lactamase inhibitor exhibiting activity against all four classes of beta-lactamase. ChEMBL:CHEMBL4584705 PubChem:76902493 VNRX-5133 antibiotic_resistance ARO:3007147 taniborbactam ARO:3007147 Taniborbactam is a broad-spectrum beta-lactamase inhibitor. As of 2022, it is in phase III clinical trials in combination with cefepime and is the only beta-lactamase inhibitor exhibiting activity against all four classes of beta-lactamase. PMID:31871094 An antibiotic cocktail containing the beta-lactam antibiotic cefepime and the beta-lactamase inhibitor taniborbactam. As of 2022, this antibiotic-adjuvant mixture is in phase III clinical trials for the treatment of various bacterial infections. antibiotic_resistance ARO:3007148 cefepime-taniborbactam ARO:3007148 An antibiotic cocktail containing the beta-lactam antibiotic cefepime and the beta-lactamase inhibitor taniborbactam. As of 2022, this antibiotic-adjuvant mixture is in phase III clinical trials for the treatment of various bacterial infections. PMID:31871094 A group of antibiotics derived from phosphonic acids. antibiotic_resistance ARO:3007149 phosphonic acid antibiotic ARO:3007149 A group of antibiotics derived from phosphonic acids. PMID:10477522 PMID:5809587 A group of antibiotics including bicyclomycin and its analogues. antibiotic_resistance ARO:3007150 bicyclomycin-like antibiotic ARO:3007150 A group of antibiotics including bicyclomycin and its analogues. PMID:7487110 A group of antibiotics including mupirocin and similar mixtures (such as those including pseudomonic acid A). antibiotic_resistance ARO:3007151 mupirocin-like antibiotic ARO:3007151 A group of antibiotics including mupirocin and similar mixtures (such as those including pseudomonic acid A). PMID:21336932 A group of antibiotics containing isoniazid and its derivatives. antibiotic_resistance ARO:3007152 isoniazid-like antibiotic ARO:3007152 A group of antibiotics containing isoniazid and its derivatives. PMID:8143118 A group of antibiotics possessing steroid rings or steroid-like structures. antibiotic_resistance ARO:3007153 fusidane antibiotic ARO:3007153 A group of antibiotics possessing steroid rings or steroid-like structures. PMID:32915993 A group of antibiotics including cycloserine and its derivatives. antibiotic_resistance ARO:3007154 cycloserine-like antibiotic ARO:3007154 A group of antibiotics including cycloserine and its derivatives. PMID:4555420 A group of antibiotics derived from pyrazine. antibiotic_resistance ARO:3007155 pyrazine antibiotic ARO:3007155 A group of antibiotics derived from pyrazine. PMID:26104205 A group of antibiotics possessing the thioamide functional group. antibiotic_resistance ARO:3007156 thioamide antibiotic ARO:3007156 A group of antibiotics possessing the thioamide functional group. PMID:26586647 A group of antibiotics including nybomycin and its derivatives. antibiotic_resistance ARO:3007157 nybomycin-like antibiotic ARO:3007157 A group of antibiotics including pactamycin and its derivatives. antibiotic_resistance ARO:3007158 pactamycin-like antibiotic ARO:3007158 A group of antibiotics derived from salicylic acid. antibiotic_resistance ARO:3007159 salicylic acid antibiotic ARO:3007159 A group of antibiotics including the experimental compound zoliflodacin and its derivatives. antibiotic_resistance ARO:3007160 zoliflodacin-like antibiotic ARO:3007160 A group of antibiotics including the experimental compound zoliflodacin and its derivatives. PMID:31730160 A group of antibiotics derived from thiosemicarbazide (possessing the thiosemicarbazone functional group). antibiotic_resistance ARO:3007161 thiosemicarbazone antibiotic ARO:3007161 A group of antibiotics derived from thiosemicarbazide (possessing the thiosemicarbazone functional group). PMID:18094751 PMID:33022959 A group of peptidomimetic antibiotics based on the peptide protegrin-1. antibiotic_resistance ARO:3007162 protegrin-1-like antibiotic ARO:3007162 A group of peptidomimetic antibiotics based on the peptide protegrin-1. PMID:20167788 A group of antibiotics including albendazole and similar antiparasitic compounds that exhibit antibacterial activity. antibiotic_resistance ARO:3007163 albendazole-like antibiotic ARO:3007163 A group of antibiotics including albendazole and similar antiparasitic compounds that exhibit antibacterial activity. PMID:35453279 A group of antibiotics derived from triazaacenaphthylene. antibiotic_resistance ARO:3007164 triazaacenaphthylene antibiotic ARO:3007164 Gemifloxacin is a broad-spectrum, fourth generation, oral fluoroquinolone antibiotic used in the treatment of various bacterial infections, primarily in the lungs. It has been discontinued for therapeutic use in the US over concerns of tendon and peripheral neuron toxicity, although it is still available for experimental application and elsewhere for therapeutic use. It is usually administered as a mesylate salt, gemifloxacin mesylate. CAS:175463-14-6 ChEBI:101853 ChEMBL:CHEMBL430 PubChem:9571107 Factive antibiotic_resistance ARO:3007165 gemifloxacin ARO:3007165 Gemifloxacin is a broad-spectrum, fourth generation, oral fluoroquinolone antibiotic used in the treatment of various bacterial infections, primarily in the lungs. It has been discontinued for therapeutic use in the US over concerns of tendon and peripheral neuron toxicity, although it is still available for experimental application and elsewhere for therapeutic use. It is usually administered as a mesylate salt, gemifloxacin mesylate. PMID:12764426 Orthosomycins are a group of experimental/veterinary orthoester and oligosaccharide antibiotics that target the 70s ribosomal subunit. They are generally no longer considered potential clinical antibiotics, but continue to be used in livestock feed and for experimental purposes. antibiotic_resistance ARO:3007166 orthosomycin antibiotic ARO:3007166 Orthosomycins are a group of experimental/veterinary orthoester and oligosaccharide antibiotics that target the 70s ribosomal subunit. They are generally no longer considered potential clinical antibiotics, but continue to be used in livestock feed and for experimental purposes. PMID:27330110 Evernimicin is a veterinary oligosaccharide antibiotic of the orthosomycin group of orthoester antibiotics. Along with avilamycin, it exhibits activity against a variety of Gram-positive and -negative bacteria and is primarily used in livestock feed. ChEMBL:CHEMBL5283245 PubChem:6917933 everninomicin antibiotic_resistance ARO:3007167 evernimicin ARO:3007167 Evernimicin is a veterinary oligosaccharide antibiotic of the orthosomycin group of orthoester antibiotics. Along with avilamycin, it exhibits activity against a variety of Gram-positive and -negative bacteria and is primarily used in livestock feed. PMID:27330110 Avilamycin is an experimental oligosaccharide antibiotic of the orthosomycin group of orthoester antibiotics. Along with evernimicin, it exhibits activity against a variety of Gram-positive and -negative bacteria. PubChem:76959299 antibiotic_resistance ARO:3007168 avalimycin ARO:3007168 Avilamycin is an experimental oligosaccharide antibiotic of the orthosomycin group of orthoester antibiotics. Along with evernimicin, it exhibits activity against a variety of Gram-positive and -negative bacteria. PMID:27330110 Pirlimycin is an experimental/veterinary lincosamide antibiotic. Although not approved for use in humans, pirlimycin is commonly used to treat mammary gland infections in cattle. ChEBI:201427 ChEMBL:CHEMBL1652611 PubChem:157385 Pirsue antibiotic_resistance ARO:3007169 pirlimycin ARO:3007169 Pirlimycin is an experimental/veterinary lincosamide antibiotic. Although not approved for use in humans, pirlimycin is commonly used to treat mammary gland infections in cattle. PMID:12584673 Enmetazobactam is a beta-lactamase inhibitor which exhibits activity against class A extended spectrum beta-lactamases. It is currently in clinical trials in combination with cefepine for the treatment of urinary tract infections and acute pyelonephritis. ChEMBL:CHEMBL4458276 PubChem:23653540 antibiotic_resistance ARO:3007171 enmetazobactam ARO:3007171 Enmetazobactam is a beta-lactamase inhibitor which exhibits activity against class A extended spectrum beta-lactamases. It is currently in clinical trials in combination with cefepine for the treatment of urinary tract infections and acute pyelonephritis. PMID:32253212 PMID:35486701 Methimazole is thiamide usually used to treat hyperthyroidism. It has also demonstrated potent inhibition of NDM-1 and synergistic effects against other metallo-beta-lactamases when paired with meropenem. CAS:60-56-0 ChEBI:50673 ChEMBL:CHEMBL1515 PubChem:1349907 Tapazole thiamazole antibiotic_resistance ARO:3007172 methimazole ARO:3007172 Methimazole is thiamide usually used to treat hyperthyroidism. It has also demonstrated potent inhibition of NDM-1 and synergistic effects against other metallo-beta-lactamases when paired with meropenem. PMID:35197545 Lipoic acid is a compound used for diabetic neuropathy and as a nutritional supplement. It has also demonstrated potent inhibition of NDM-1 and synergistic effects against other metallo-beta-lactamases when paired with meropenem. ChEBI:16494 ChEMBL:CHEMBL33864 PubChem:864 alpha-lipoic acid antibiotic_resistance ARO:3007173 lipoic acid ARO:3007173 Lipoic acid is a compound used for diabetic neuropathy and as a nutritional supplement. It has also demonstrated potent inhibition of NDM-1 and synergistic effects against other metallo-beta-lactamases when paired with meropenem. PMID:35197545 Scutellarin is an experimental antibiotic potentiator that inhibits bacterial sortase A and caseinolytic peptidase P. When used in combination with vancomycin against methicillin-resistant Staphylococcus aureus, scutellarin improves activity of the antibiotic, making it an effective adjuvant in the treatment of such infections. CAS:27740-01-8 ChEBI:61278 ChEMBL:CHEMBL487805 PubChem:185617 antibiotic_resistance ARO:3007174 scutellarin ARO:3007174 Scutellarin is an experimental antibiotic potentiator that inhibits bacterial sortase A and caseinolytic peptidase P. When used in combination with vancomycin against methicillin-resistant Staphylococcus aureus, scutellarin improves activity of the antibiotic, making it an effective adjuvant in the treatment of such infections. PMID:35247333 TP0586532 is an antibiotic potentiator that acts by inhibiting bacterial LpxC, interfering with the production of lipopolysaccharides. It has been shown to increase the effects of several antibiotics, such as meropenem, amikacin, cefepime, and tigecycline. The disruption of lipopolysaccharide synthesis is suspected to lead to increased membrane permeability. PubChem:155294517 antibiotic_resistance ARO:3007175 TP0586532 ARO:3007175 TP0586532 is an antibiotic potentiator that acts by inhibiting bacterial LpxC, interfering with the production of lipopolysaccharides. It has been shown to increase the effects of several antibiotics, such as meropenem, amikacin, cefepime, and tigecycline. The disruption of lipopolysaccharide synthesis is suspected to lead to increased membrane permeability. PMID:35647694 TNP-2198 is an experimental rifamycin-nitroimidazole conjugate currently in development for treatment of several bacterial infections. It exhibits greater activity than rifamycin and nitroimidazole antibiotics administered together and is effective against bacteria resistant to both drug classes. ChEMBL:CHEMBL5314439 PubChem:136014272 antibiotic_resistance ARO:3007176 TNP-2198 ARO:3007176 TNP-2198 is an experimental rifamycin-nitroimidazole conjugate currently in development for treatment of several bacterial infections. It exhibits greater activity than rifamycin and nitroimidazole antibiotics administered together and is effective against bacteria resistant to both drug classes. PMID:35175750 Antibiotics belonging to the thiazolide group. Note that many thiazolides are used as antiviral compounds, however some have also exhibited antibacterial activity. antibiotic_resistance ARO:3007177 thiazolide antibiotic ARO:3007177 Nitazoxanide is a thiazolide antiparatasitic and antiviral drug that has demonstrated antibacterial activity against Helicobacter pylori. It is well tolerated and exhibits a synergistic effect with other antibiotics, such as clarithromycin. ChEMBL:CHEMBL1401 PubChem:41684 Alinia Nizonide nitazoxamide antibiotic_resistance ARO:3007178 nitazoxanide ARO:3007178 Nitazoxanide is a thiazolide antiparatasitic and antiviral drug that has demonstrated antibacterial activity against Helicobacter pylori. It is well tolerated and exhibits a synergistic effect with other antibiotics, such as clarithromycin. PMID:35587063 Class A beta-lactamse from M. abscessus. antibiotic_resistance ARO:3007179 class A Mycobacterium abscessus beta-lactamase ARO:3007179 Class A beta-lactamse from M. abscessus. PMID:24132992 PMID:28096155 MAB is a broad-spectrum class A beta-lactamase produced by Mycobacterium abscessus that has been shown to hydrolyze a large number of beta-lactam antibiotics. MAB antibiotic_resistance ARO:3007180 MAB ARO:3007180 MAB is a broad-spectrum class A beta-lactamase produced by Mycobacterium abscessus that has been shown to hydrolyze a large number of beta-lactam antibiotics. PMID:24132992 PMID:28096155 MAB Class A beta-lactamase from M. tuberculosis. antibiotic_resistance ARO:3007181 class A Mycobacterium tuberculosis bla beta-lactamase ARO:3007181 Class A beta-lactamase from M. tuberculosis. PMID:20353175 PMID:24132992 blaC is a broad-spectrum class A beta-lactamase coded in the chromosome of Mycobacterium tuberculosis. It has been shown to hydrolyze a large number of beta-lactam antibiotics and is a major obstacle in the treatment of tuberculosis with such drugs. blaC antibiotic_resistance ARO:3007182 blaC ARO:3007182 blaC is a broad-spectrum class A beta-lactamase coded in the chromosome of Mycobacterium tuberculosis. It has been shown to hydrolyze a large number of beta-lactam antibiotics and is a major obstacle in the treatment of tuberculosis with such drugs. PMID:20353175 PMID:24132992 blaC Mutations in the Rv1258c (Tap) efflux pump contributing to antibiotic resistance. antibiotic_resistance ARO:3007183 antibiotic resistant Rv1258c ARO:3007183 Mutations in the Rv1258c efflux pump contributing to resistance to multiple antibiotics. antibiotic_resistance ARO:3007184 multidrug resistant Rv1258c ARO:3007184 Mutations in the Rv1258c efflux pump contributing to resistance to multiple antibiotics. PMID:30837962 PMID:35158297 Mutations in the M. tuberculosis efflux pump Rv1258c (Tap) conferring resistance to multiple ethambutol and capreomycin. Mtub_tap_EMCM Rv1258c antibiotic_resistance ARO:3007185 Mycobacterium tuberculosis Rv1258c mutations confer resistance to ethambutol and capreomycin ARO:3007185 Mutations in the M. tuberculosis efflux pump Rv1258c (Tap) conferring resistance to multiple ethambutol and capreomycin. PMID:35158297 Mtub_tap_EMCM Mutations in the M. tuberculosis efflux pump Rv1258c (Tap) conferring resistance to pyrazinamide, isoniazid, and streptomycin. Mtub_tap_MULT Rv1258c antibiotic_resistance ARO:3007186 Mycobacterium tuberculosis Rv1258c mutations confer resistance to pyrazinamide, isoniazid, and streptomycin ARO:3007186 Mutations in the M. tuberculosis efflux pump Rv1258c (Tap) conferring resistance to pyrazinamide, isoniazid, and streptomycin. PMID:30837962 Mtub_tap_MULT This cluster confers resistance to both vancomycin and teicoplanin by allowing restructuring of peptidoglycan precursors to end in D-Ala-D-Lac. Resistance is acquired after multiple treatments with sub-minimum inhibitory concentrations of vancomycin. Gene orientation: vanHPXRS. vanP_cluster antibiotic_resistance ARO:3007187 glycopeptide resistance gene cluster vanP ARO:3007187 This cluster confers resistance to both vancomycin and teicoplanin by allowing restructuring of peptidoglycan precursors to end in D-Ala-D-Lac. Resistance is acquired after multiple treatments with sub-minimum inhibitory concentrations of vancomycin. Gene orientation: vanHPXRS. PMID:34505571 vanP_cluster vanH variant in the vanP cluster. vanH-P vanHP vanH_in_vanP_cl antibiotic_resistance ARO:3007188 vanH gene in vanP cluster ARO:3007188 vanH variant in the vanP cluster. PMID:34505571 vanH_in_vanP_cl vanP is a D-Ala-D-Ala ligase homolog that synthesizes D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance. vanP antibiotic_resistance ARO:3007189 vanP ARO:3007189 vanP is a D-Ala-D-Ala ligase homolog that synthesizes D-Ala-D-Lac, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity. It is associated with both vancomycin and teicoplanin resistance. PMID:34505571 vanP vanX variant in the vanP cluster. vanX-P vanXP vanX_in_vanP_cl antibiotic_resistance ARO:3007190 vanX gene in vanP cluster ARO:3007190 vanX variant in the vanP cluster. PMID:34505571 vanX_in_vanP_cl vanR variant in the vanP cluster. vanR-P vanRP vanR_in_vanP_cl antibiotic_resistance ARO:3007191 vanR gene in vanP cluster ARO:3007191 vanR variant in the vanP cluster. PMID:34505571 vanR_in_vanP_cl vanS variant in the vanP cluster. vanS-P vanSP vanS_in_vanP_cl antibiotic_resistance ARO:3007192 vanS gene in vanP cluster ARO:3007192 vanS variant in the vanP cluster. PMID:34505571 vanS_in_vanP_cl Groups, organizations, and government bodies dedicated to the surveillance of antimicrobial resistance. antibiotic_resistance ARO:3007194 antimicrobial resistance surveillance systems ARO:3007194 The National Antimicrobial Resistance Monitoring System for Enteric Bacteria (NARMS) is a US public health surveillance system that tracks antimicrobial resistance in foodborne and other enteric bacteria. antibiotic_resistance ARO:3007195 National Antimicrobial Resistance Monitoring System (NARMS) ARO:3007195 The National Antimicrobial Resistance Monitoring System for Enteric Bacteria (NARMS) is a US public health surveillance system that tracks antimicrobial resistance in foodborne and other enteric bacteria. PMID:17927472 KPC-123 is a KPC beta-lactamase. KPC-123 antibiotic_resistance ARO:3007196 KPC-123 ARO:3007196 KPC-123 is a KPC beta-lactamase. PMID:35794918 KPC-123 Enramycin is a polypeptide antibiotic commonly used as a feed additive for livestock. It is produced by species of the Streptomyces genus and is used to prevent necrotic enteritis in poultry and pigs. Enramycin disrupts cell wall synthesis by inhibiting MurG. ChEMBL:CHEMBL2109091 PubChem:56842192 antibiotic_resistance ARO:3007197 enramycin ARO:3007197 Enramycin is a polypeptide antibiotic commonly used as a feed additive for livestock. It is produced by species of the Streptomyces genus and is used to prevent necrotic enteritis in poultry and pigs. Enramycin disrupts cell wall synthesis by inhibiting MurG. PMID:35841645 A family of subclass B3 metallo-beta-lactamases discovered in Pseudomonas alcaligenes and found in other members of the Pseudomonas genus. PAM beta-lactamases hydrolyze cephalosporins and carbenems. antibiotic_resistance ARO:3007198 PAM beta-lactamase ARO:3007198 A family of subclass B3 metallo-beta-lactamases discovered in Pseudomonas alcaligenes and found in other members of the Pseudomonas genus. PAM beta-lactamases hydrolyze cephalosporins and carbenems. PMID:24356301 PMID:33577996 PAM-1 is a member of the PAM family of subclass B3 metallo-beta-lactamases found in members of the Psuedomonas genus. PAM-1 antibiotic_resistance ARO:3007199 PAM-1 ARO:3007199 PAM-1 is a member of the PAM family of subclass B3 metallo-beta-lactamases found in members of the Psuedomonas genus. PMID:24356301 PAM-1 PAM-2 is a member of the PAM family of subclass B3 metallo-beta-lactamases found in members of the Pseudomonas genus. PAM-2 antibiotic_resistance ARO:3007200 PAM-2 ARO:3007200 PAM-2 is a member of the PAM family of subclass B3 metallo-beta-lactamases found in members of the Pseudomonas genus. PMID:33577996 PAM-2 PAM-3 is a member of the PAM family of subclass B3 metallo-beta-lactamases found in members of the Pseudomonas genus. PAM-3 antibiotic_resistance ARO:3007201 PAM-3 ARO:3007201 PAM-3 New Delhi class B metallo-beta-lactamase 16b variant. NDM-16b antibiotic_resistance ARO:3007202 NDM-16b ARO:3007202 New Delhi class B metallo-beta-lactamase 16b variant. PMID:35867355 NDM-16b Mutations in Klebsiella pneumoniae PhoQ of the two-component PhoPQ regulatory system conferring resistance to colistin. Kpne_PhoQ_CST antibiotic_resistance ARO:3007203 Klebsiella pneumoniae mutant PhoQ conferring resistance to colistin ARO:3007203 Mutations in Klebsiella pneumoniae PhoQ of the two-component PhoPQ regulatory system conferring resistance to colistin. PMID:35920875 Kpne_PhoQ_CST AAC(6')-Iap is an aminoglycoside acetyltransferase that confers resistance to a number of aminoglycoside antibiotics. AAC(6')-Iap antibiotic_resistance ARO:3007204 AAC(6')-Iap ARO:3007204 AAC(6')-Iap is an aminoglycoside acetyltransferase that confers resistance to a number of aminoglycoside antibiotics. PMID:35862995 AAC(6')-Iap Kathmandu beta-lactamases are a group of class A beta-lactamases that hydrolyze penicillin antibiotics. antibiotic_resistance ARO:3007205 KBL beta-lactamase ARO:3007205 Kathmandu beta-lactamases are a group of class A beta-lactamases that hydrolyze penicillin antibiotics. PMID:35862995 KBL-1 is a KBL class A beta-lactamase that confers resistance to a number of penicillin antibiotics. KBL-1 antibiotic_resistance ARO:3007206 KBL-1 ARO:3007206 KBL-1 is a KBL class A beta-lactamase that confers resistance to a number of penicillin antibiotics. PMID:35862995 KBL-1 Helicase-like proteins that confer resistance to antibiotics such as rifamycins by preventing or disrupting their binding to RNA polymerase. antibiotic_resistance ARO:3007207 helicase-like RNA polymerase protection protein ARO:3007207 Helicase-like proteins that confer resistance to antibiotics such as rifamycins by preventing or disrupting their binding to RNA polymerase. PMID:35907401 HelR is a helicase-like protein that confers resistance to rifamycins by displacing them from the RNA polymerase complex. The protein forces the antibiotic away from the polymerase by binding in its place. It then ejects itself from the complex, allowing the polymerase to resume normal function. HelR antibiotic_resistance ARO:3007208 HelR ARO:3007208 HelR is a helicase-like protein that confers resistance to rifamycins by displacing them from the RNA polymerase complex. The protein forces the antibiotic away from the polymerase by binding in its place. It then ejects itself from the complex, allowing the polymerase to resume normal function. PMID:35907401 HelR Streptomyces venezuelae rox is a class A flavoprotein monooxygenase that confers resistance to rifamycin antibiotics. It acts by oxygenating the naphthyl group of the antibiotic, leading to a ring opening event and linearization of the molecule. Rox-sv Sven_rox antibiotic_resistance ARO:3007209 Streptomyces venezuelae rox ARO:3007209 Streptomyces venezuelae rox is a class A flavoprotein monooxygenase that confers resistance to rifamycin antibiotics. It acts by oxygenating the naphthyl group of the antibiotic, leading to a ring opening event and linearization of the molecule. PMID:29398560 Sven_rox Nocardia farcinica rox is a rifampin monooxygenase that inactivates rifampin. Nfar_rox Rox-nf antibiotic_resistance ARO:3007210 Nocardia farcinica rox ARO:3007210 Nocardia farcinica rox is a rifampin monooxygenase that inactivates rifampin. PMID:19942945 Nfar_rox NDM-34 is a NDM beta-lactamase. NDM-34 antibiotic_resistance ARO:3007211 NDM-34 ARO:3007211 NDM-34 NDM-35 is a NDM beta-lactamase. NDM-35 antibiotic_resistance ARO:3007212 NDM-35 ARO:3007212 NDM-35 NDM-36 is a NDM beta-lactamase. NDM-36 antibiotic_resistance ARO:3007213 NDM-36 ARO:3007213 NDM-36 NDM-37 is a NDM beta-lactamase. NDM-37 antibiotic_resistance ARO:3007214 NDM-37 ARO:3007214 NDM-37 NDM-38 is a NDM beta-lactamase. NDM-38 antibiotic_resistance ARO:3007215 NDM-38 ARO:3007215 NDM-38 NDM-39 is a NDM beta-lactamase. NDM-39 antibiotic_resistance ARO:3007216 NDM-39 ARO:3007216 NDM-39 NDM-40 is a NDM beta-lactamase. NDM-40 antibiotic_resistance ARO:3007217 NDM-40 ARO:3007217 NDM-40 NDM-41 is a NDM beta-lactamase. NDM-41 antibiotic_resistance ARO:3007218 NDM-41 ARO:3007218 NDM-41 NDM-42 is a NDM beta-lactamase. NDM-42 antibiotic_resistance ARO:3007219 NDM-42 ARO:3007219 NDM-42 NDM-43 is a NDM beta-lactamase. NDM-43 antibiotic_resistance ARO:3007220 NDM-43 ARO:3007220 NDM-43 An experimental polypyridine ligand used as a metallo-beta-lactamase inhibitor. N,N,N'-tris(2-pyridylmethyl)-ethylenediamine-N'-acetic acid antibiotic_resistance ARO:3007221 trispicen A ARO:3007221 An experimental polypyridine ligand used as a metallo-beta-lactamase inhibitor. PMID:33285370 A class of antibiotic adjuvant in which the adjuvant directly or indirectly inhibits the mechanism of resistance, restoring antibiotic susceptibility or decreasing the minimum inhibitory concentration. antibiotic_resistance ARO:3007222 inhibitor of antibiotic resistance mechanism ARO:3007222 A class of antibiotic adjuvants which enhance the antibiotic capability to enter the cell through passive or active membrane transport. antibiotic_resistance ARO:3007223 adjuvants enhancing antibiotic entry ARO:3007223 A class of adjuvants which inhibit or prevent the cellular removal of an antibiotic through mechanisms including antibiotic efflux. antibiotic_resistance ARO:3007224 adjuvants inhibiting antibiotic removal ARO:3007224 A class of antibiotic adjuvants which indirectly increase antibiotic susceptibility through alterations to cellular physiology, for example those adjuvants which inhibit biofilm formation. antibiotic_resistance ARO:3007225 adjuvants which alter physiology ARO:3007225 A class of antibiotic adjuvants which indirectly improve antibiotic susceptibility or retention through alterations to host physiology or metabolism. antibiotic_resistance ARO:3007226 host-related antibiotic adjuvants ARO:3007226 An MCR-8-type colistin resistance gene variant. MCR-8.3 antibiotic_resistance ARO:3007227 MCR-8.3 ARO:3007227 An MCR-8-type colistin resistance gene variant. PMID:31849875 MCR-8.3 An MCR-8-type colistin resistance gene variant. MCR-8.4 antibiotic_resistance ARO:3007228 MCR-8.4 ARO:3007228 An MCR-8-type colistin resistance gene variant. PMID:30828324 MCR-8.4 An MCR-8-type colistin resistance gene variant. MCR-8.2 antibiotic_resistance ARO:3007229 MCR-8.2 ARO:3007229 An MCR-8-type colistin resistance gene variant. PMID:30864883 MCR-8.2 An MCR-1-type colistin resistance gene variant. MCR-1.34 antibiotic_resistance ARO:3007230 MCR-1.34 ARO:3007230 MCR-1.34 An MCR-4-type colistin resistance gene variant. MCR-4.6 antibiotic_resistance ARO:3007231 MCR-4.6 ARO:3007231 MCR-4.6 An MCR-1-type colistin resistance gene variant. MCR-1.27 antibiotic_resistance ARO:3007232 MCR-1.27 ARO:3007232 MCR-1.27 An MCR-1-type colistin resistance gene variant. MCR-1.18 antibiotic_resistance ARO:3007233 MCR-1.18 ARO:3007233 MCR-1.18 An MCR-1-type colistin resistance gene variant. MCR-1.23 antibiotic_resistance ARO:3007234 MCR-1.23 ARO:3007234 MCR-1.23 An MCR-1-type colistin resistance gene variant. MCR-1.20 antibiotic_resistance ARO:3007235 MCR-1.20 ARO:3007235 MCR-1.20 An MCR-1-type colistin resistance gene variant. MCR-1.28 antibiotic_resistance ARO:3007236 MCR-1.28 ARO:3007236 MCR-1.28 An MCR-1-type colistin resistance gene variant. MCR-1.21 antibiotic_resistance ARO:3007237 MCR-1.21 ARO:3007237 MCR-1.21 An MCR-1-type colistin resistance gene variant. MCR-1.16 antibiotic_resistance ARO:3007238 MCR-1.16 ARO:3007238 MCR-1.16 An MCR-1-type colistin resistance gene variant. MCR-1.22 antibiotic_resistance ARO:3007239 MCR-1.22 ARO:3007239 An MCR-1-type colistin resistance gene variant. PMID:34091039 MCR-1.22 An MCR-1-type colistin resistance gene variant. MCR-1.19 antibiotic_resistance ARO:3007240 MCR-1.19 ARO:3007240 MCR-1.19 An MCR-1-type colistin resistance gene variant. MCR-1.29 antibiotic_resistance ARO:3007241 MCR-1.29 ARO:3007241 MCR-1.29 An MCR-1-type colistin resistance gene variant. MCR-1.30 antibiotic_resistance ARO:3007242 MCR-1.30 ARO:3007242 MCR-1.30 An MCR-1-type colistin resistance gene variant. MCR-1.24 antibiotic_resistance ARO:3007243 MCR-1.24 ARO:3007243 MCR-1.24 An MCR-1-type colistin resistance gene variant. MCR-1.17 antibiotic_resistance ARO:3007244 MCR-1.17 ARO:3007244 MCR-1.17 An MCR-1-type colistin resistance gene variant. MCR-1.31 antibiotic_resistance ARO:3007245 MCR-1.31 ARO:3007245 MCR-1.31 An MCR-1-type colistin resistance gene variant. MCR-1.14 antibiotic_resistance ARO:3007246 MCR-1.14 ARO:3007246 MCR-1.14 An MCR-1-type colistin resistance gene variant. MCR-1.25 antibiotic_resistance ARO:3007247 MCR-1.25 ARO:3007247 MCR-1.25 An MCR-3-type colistin resistance gene variant. MCR-3.33 antibiotic_resistance ARO:3007248 MCR-3.33 ARO:3007248 An MCR-3-type colistin resistance gene variant. PMID:34187559 MCR-3.33 An MCR-3-type colistin resistance gene variant. MCR-3.14 antibiotic_resistance ARO:3007249 MCR-3.14 ARO:3007249 MCR-3.14 An MCR-3-type colistin resistance gene variant. MCR-3.37 antibiotic_resistance ARO:3007250 MCR-3.37 ARO:3007250 An MCR-3-type colistin resistance gene variant. PMID:34187559 MCR-3.37 An MCR-3-type colistin resistance gene variant. MCR-3.38 antibiotic_resistance ARO:3007251 MCR-3.38 ARO:3007251 MCR-3.38 An MCR-3-type colistin resistance gene variant. MCR-3.15 antibiotic_resistance ARO:3007252 MCR-3.15 ARO:3007252 MCR-3.15 An MCR-3-type colistin resistance gene variant. MCR-3.27 antibiotic_resistance ARO:3007253 MCR-3.27 ARO:3007253 MCR-3.27 An MCR-3-type colistin resistance gene variant. MCR-3.32 antibiotic_resistance ARO:3007254 MCR-3.32 ARO:3007254 MCR-3.32 An MCR-3-type colistin resistance gene variant. MCR-3.31 antibiotic_resistance ARO:3007255 MCR-3.31 ARO:3007255 MCR-3.31 An MCR-3-type colistin resistance gene variant. MCR-3.23 antibiotic_resistance ARO:3007256 MCR-3.23 ARO:3007256 MCR-3.23 An MCR-3-type colistin resistance gene variant. MCR-3.36 antibiotic_resistance ARO:3007257 MCR-3.36 ARO:3007257 An MCR-3-type colistin resistance gene variant. PMID:34187559 MCR-3.36 An MCR-3-type colistin resistance gene variant. MCR-3.25 antibiotic_resistance ARO:3007258 MCR-3.25 ARO:3007258 MCR-3.25 An MCR-3-type colistin resistance gene variant. MCR-3.22 antibiotic_resistance ARO:3007259 MCR-3.22 ARO:3007259 MCR-3.22 An MCR-3-type colistin resistance gene variant. MCR-3.16 antibiotic_resistance ARO:3007260 MCR-3.16 ARO:3007260 MCR-3.16 An MCR-3-type colistin resistance gene variant. MCR-3.26 antibiotic_resistance ARO:3007261 MCR-3.26 ARO:3007261 MCR-3.26 An MCR-3-type colistin resistance gene variant. MCR-3.21 antibiotic_resistance ARO:3007262 MCR-3.21 ARO:3007262 MCR-3.21 An MCR-3-type colistin resistance gene variant. MCR-3.18 antibiotic_resistance ARO:3007263 MCR-3.18 ARO:3007263 MCR-3.18 An MCR-3-type colistin resistance gene variant. MCR-3.40 antibiotic_resistance ARO:3007264 MCR-3.40 ARO:3007264 MCR-3.40 An MCR-3-type colistin resistance gene variant. MCR-3.24 antibiotic_resistance ARO:3007265 MCR-3.24 ARO:3007265 MCR-3.24 An MCR-3-type colistin resistance gene variant. MCR-3.20 antibiotic_resistance ARO:3007266 MCR-3.20 ARO:3007266 MCR-3.20 An MCR-3-type colistin resistance gene variant. MCR-3.35 antibiotic_resistance ARO:3007267 MCR-3.35 ARO:3007267 An MCR-3-type colistin resistance gene variant. PMID:34187559 MCR-3.35 An MCR-3-type colistin resistance gene variant. MCR-3.34 antibiotic_resistance ARO:3007268 MCR-3.34 ARO:3007268 An MCR-3-type colistin resistance gene variant. PMID:34187559 MCR-3.34 An MCR-3-type colistin resistance gene variant. MCR-3.13 antibiotic_resistance ARO:3007269 MCR-3.13 ARO:3007269 MCR-3.13 An MCR-3-type colistin resistance gene variant. MCR-3.28 antibiotic_resistance ARO:3007270 MCR-3.28 ARO:3007270 MCR-3.28 An MCR-3-type colistin resistance gene variant. MCR-3.39 antibiotic_resistance ARO:3007271 MCR-3.39 ARO:3007271 MCR-3.39 An MCR-3-type colistin resistance gene variant. MCR-3.29 antibiotic_resistance ARO:3007272 MCR-3.29 ARO:3007272 MCR-3.29 An MCR-3-type colistin resistance gene variant. MCR-3.19 antibiotic_resistance ARO:3007273 MCR-3.19 ARO:3007273 MCR-3.19 An MCR-10-type colistin resistance gene variant. MCR-10.5 antibiotic_resistance ARO:3007274 MCR-10.5 ARO:3007274 MCR-10.5 An MCR-10-type colistin resistance gene variant. MCR-10.3 antibiotic_resistance ARO:3007275 MCR-10.3 ARO:3007275 MCR-10.3 An MCR-10-type colistin resistance gene variant. MCR-10.4 antibiotic_resistance ARO:3007276 MCR-10.4 ARO:3007276 MCR-10.4 An MCR-10-type colistin resistance gene variant. MCR-10.2 antibiotic_resistance ARO:3007277 MCR-10.2 ARO:3007277 MCR-10.2 An MCR-3-type colistin resistance gene variant. MCR-3.17 antibiotic_resistance ARO:3007278 MCR-3.17 ARO:3007278 MCR-3.17 An MCR-1-type colistin resistance gene variant. MCR-1.15 antibiotic_resistance ARO:3007279 MCR-1.15 ARO:3007279 MCR-1.15 An MCR-1-type colistin resistance gene variant. MCR-1.26 antibiotic_resistance ARO:3007280 MCR-1.26 ARO:3007280 MCR-1.26 An MCR-5-type colistin resistance gene variant. MCR-5.4 antibiotic_resistance ARO:3007281 MCR-5.4 ARO:3007281 MCR-5.4 An MCR-5-type colistin resistance gene variant. MCR-5.3 antibiotic_resistance ARO:3007282 MCR-5.3 ARO:3007282 An MCR-5-type colistin resistance gene variant. PMID:30864883 MCR-5.3 An MCR-2-type colistin resistance gene variant. MCR-2.4 antibiotic_resistance ARO:3007283 MCR-2.4 ARO:3007283 MCR-2.4 An MCR-2-type colistin resistance gene variant. MCR-2.3 antibiotic_resistance ARO:3007284 MCR-2.3 ARO:3007284 MCR-2.3 An MCR-2-type colistin resistance gene variant. MCR-2.8 antibiotic_resistance ARO:3007285 MCR-2.8 ARO:3007285 MCR-2.8 An MCR-2-type colistin resistance gene variant. MCR-2.5 antibiotic_resistance ARO:3007286 MCR-2.5 ARO:3007286 MCR-2.5 An MCR-2-type colistin resistance gene variant. MCR-2.7 antibiotic_resistance ARO:3007287 MCR-2.7 ARO:3007287 MCR-2.7 An MCR-2-type colistin resistance gene variant. MCR-2.6 antibiotic_resistance ARO:3007288 MCR-2.6 ARO:3007288 MCR-2.6 An MCR-1-type colistin resistance gene variant. MCR-1.32 antibiotic_resistance ARO:3007289 MCR-1.32 ARO:3007289 MCR-1.32 Adjuvants shown to inhibit the action of fosfomycin thiol transferases. antibiotic_resistance ARO:3007290 fosfomycin thiol transferase inhibitor ARO:3007290 Adjuvants shown to inhibit the action of fosfomycin thiol transferases. PMID:15504029 Adjuvants shown to inhibit the action of aminoglycoside inactivating enzymes, such as the APH and AAC enzyme families. antibiotic_resistance ARO:3007291 inhibitor of aminoglycoside inactivation enzyme ARO:3007291 Adjuvants shown to inhibit the action of aminoglycoside inactivating enzymes, such as the APH and AAC enzyme families. PMID:22760297 PMID:23758273 Adjuvants shown to inhibit the action of mobile colistin resistance phosphoethanolamine transferase genes. antibiotic_resistance ARO:3007292 MCR phosphoethanolamine transferase inhibitor ARO:3007292 Adjuvants shown to inhibit the action of mobile colistin resistance phosphoethanolamine transferase genes. PMID:29339386 Durlobactam is a broad-spectrum diazabicyclooctane beta-lactamase inhibitor capable to inhibiting class A, C, and D beta-lactamases. ChEBI:229539 ChEMBL:CHEMBL4298137 PubChem:89851852 ETX-2514 antibiotic_resistance ARO:3007293 durlobactam ARO:3007293 Durlobactam is a broad-spectrum diazabicyclooctane beta-lactamase inhibitor capable to inhibiting class A, C, and D beta-lactamases. PMID:34349751 ANT-431 is an experimental beta-lactamase inhibitor shown to inhibit the action of NDM-1 and VIM-2. PubChem:86566878 antibiotic_resistance ARO:3007294 ANT-431 ARO:3007294 ANT-431 is an experimental beta-lactamase inhibitor shown to inhibit the action of NDM-1 and VIM-2. PMID:29530861 Nacubactam is a diazabicyclooctane that inhibits a variety of class A and C beta-lactamases. ChEMBL:CHEMBL3989959 PubChem:73386748 antibiotic_resistance ARO:3007295 nacubactam ARO:3007295 Nacubactam is a diazabicyclooctane that inhibits a variety of class A and C beta-lactamases. PMID:31182530 Zidebactam is a diazabicyclooctane that inhibitors a variety of class A and C beta-lactamases. ChEMBL:CHEMBL4533605 PubChem:77846445 antibiotic_resistance ARO:3007296 zidebactam ARO:3007296 Zidebactam is a diazabicyclooctane that inhibitors a variety of class A and C beta-lactamases. PMID:30670419 ARX1796 is an orally bioavailable prodrug of avibactam. ChEMBL:CHEMBL4284604 PubChem:135339165 antibiotic_resistance ARO:3007297 ARX1796 ARO:3007297 ARX1796 is an orally bioavailable prodrug of avibactam. PMID:34357517 Ledaborbactam is an experimental boronic acid beta-lactamase inhibitor that has shown been show to inhibitor several serine beta-lactamases. ChEMBL:CHEMBL5093566 PubChem:138455079 VNRX-5236 antibiotic_resistance ARO:3007298 ledaborbactam ARO:3007298 Ledaborbactam is an experimental boronic acid beta-lactamase inhibitor that has shown been show to inhibitor several serine beta-lactamases. PMID:34001510 Ledaborbactam Etzadroxil is an orally bioavailable prodrug of ledaborbactam. ChEMBL:CHEMBL4594425 PubChem:138455030 VNRX-7145 antibiotic_resistance ARO:3007299 ledaborbactam etzadroxil ARO:3007299 Ledaborbactam Etzadroxil is an orally bioavailable prodrug of ledaborbactam. PMID:34191513 L-captopril is a drug used to treat hypertension that has been shown to chelate certain metallo-beta-lactamases. CAS:62571-86-2 ChEBI:3380 ChEMBL:CHEMBL1560 PubChem:44093 antibiotic_resistance ARO:3007300 L-captopril ARO:3007300 L-captopril is a drug used to treat hypertension that has been shown to chelate certain metallo-beta-lactamases. PMID:26482303 D-captopril is an isomer of L-captopril and is able to chelate certain metallo-beta-lactamases. ChEMBL:CHEMBL434965 PubChem:447055 antibiotic_resistance ARO:3007301 D-captopril ARO:3007301 D-captopril is an isomer of L-captopril and is able to chelate certain metallo-beta-lactamases. PMID:26482303 Thiorphan is the active metabolite of the antidieuretic drug racecadotril. It has shown inhibitory activity against various metallo-beta-lactamases. CAS:76721-89-6 ChEBI:9568 ChEMBL:CHEMBL10247 PubChem:3132 antibiotic_resistance ARO:3007302 thiorphan ARO:3007302 Thiorphan is the active metabolite of the antidieuretic drug racecadotril. It has shown inhibitory activity against various metallo-beta-lactamases. PMID:31663735 Tiopronin is a drug used to prevent and manage kidney stones in cystinuria patients. It has shown inhibitory activity against various metallo-beta-lactamases. CAS:1953-02-2 ChEBI:32229 ChEMBL:CHEMBL1314 PubChem:5483 antibiotic_resistance ARO:3007303 tiopronin ARO:3007303 Tiopronin is a drug used to prevent and manage kidney stones in cystinuria patients. It has shown inhibitory activity against various metallo-beta-lactamases. PMID:31663735 Dimercaprol is a compound used to treat acute arsenic poisoning, as well as poisoning of other metals such as mercury, gold, and antimony. It has shown inhibitory activity against various metallo-beta-lactamases. CAS:59-52-9 ChEBI:64198 ChEMBL:CHEMBL1597 PubChem:3080 antibiotic_resistance ARO:3007304 dimercaprol ARO:3007304 Dimercaprol is a compound used to treat acute arsenic poisoning, as well as poisoning of other metals such as mercury, gold, and antimony. It has shown inhibitory activity against various metallo-beta-lactamases. PMID:31663735 ME1071 is an experimental metallo-beta-lactamase inhibitor. ChEMBL:CHEMBL1673299 PubChem:16064853 antibiotic_resistance ARO:3007305 ME1071 ARO:3007305 ME1071 is an experimental metallo-beta-lactamase inhibitor. PMID:23891525 Phosphonoformate, also known as Forscarnet or Foscavir, is an antiviral drug used to treat Herpesviridae infections. It has also been shown to inhibit the fosfomycin thiol transferase fosA. CAS:4428-95-9 ChEBI:127780 ChEMBL:CHEMBL666 PubChem:3415 Foscarnet Foscavir antibiotic_resistance ARO:3007306 phosphonoformate ARO:3007306 Phosphonoformate, also known as Forscarnet or Foscavir, is an antiviral drug used to treat Herpesviridae infections. It has also been shown to inhibit the fosfomycin thiol transferase fosA. PMID:15504029 PMID:28993329 Phosphonoacetate is an experimental inhibitor of the fosfomycin thiol transferase fosA. CAS:4408-78-0 ChEBI:15732 ChEMBL:CHEMBL50300 PubChem:546 antibiotic_resistance ARO:3007307 phosphonoacetate ARO:3007307 Phosphonoacetate is an experimental inhibitor of the fosfomycin thiol transferase fosA. PMID:15504029 Phosphonoacetate is an experimental inhibitor of the fosfomycin thiol transferase fosA. ChEBI:18124 PubChem:490 antibiotic_resistance ARO:3007308 acetylphosphonate ARO:3007308 Phosphonoacetate is an experimental inhibitor of the fosfomycin thiol transferase fosA. PMID:15504029 Quercetin is a common plant flavonoid that has shown inhibitory activity against certain aminoglycoside inactivation enzymes. Quercetin is also able to inhibit antbiotic efflux pumps such as AcrAB-TolC. CAS:117-39-5 ChEBI:16243 ChEMBL:CHEMBL50 PubChem:5280343 antibiotic_resistance ARO:3007309 quercetin ARO:3007309 Quercetin is a common plant flavonoid that has shown inhibitory activity against certain aminoglycoside inactivation enzymes. Quercetin is also able to inhibit antbiotic efflux pumps such as AcrAB-TolC. PMID:23758273 PMID:31755586 Aranorosin is a plant derived compound that has shown inhibitory activity against certain aminoglycoside inactivation enzymes. ChEBI:221931 ChEMBL:CHEMBL4646330 PubChem:6444217 antibiotic_resistance ARO:3007310 aranorosin ARO:3007310 Aranorosin is a plant derived compound that has shown inhibitory activity against certain aminoglycoside inactivation enzymes. PMID:22760297 Pterostilbene is a stilbenoid compound with antioxidant effects found in members of the genus Vaccinium (blueberries). It has also been shown to partially inhibit the mobile colistin resistance gene MCR-1. CAS:537-42-8 ChEBI:8630 ChEMBL:CHEMBL83527 PubChem:5281727 antibiotic_resistance ARO:3007311 pterostilbene ARO:3007311 Pterostilbene is a stilbenoid compound with antioxidant effects found in members of the genus Vaccinium (blueberries). It has also been shown to partially inhibit the mobile colistin resistance gene MCR-1. PMID:29339386 SPR741 is an experimental cationic peptide used to increase permeability of the outer membrane of Gram-negative bacteria. It is currently in clinical trials in combination with a variety of antibiotics. PubChem:53323381 antibiotic_resistance ARO:3007312 SPR741 ARO:3007312 SPR741 is an experimental cationic peptide used to increase permeability of the outer membrane of Gram-negative bacteria. It is currently in clinical trials in combination with a variety of antibiotics. PMID:28947471 KL-L9P is an experimental peptide used to increase the permeability of Gram-negative bacterial membranes to enhance the entry of antibiotics such as linezolid, rifampicin, and clarithromycin. ChEMBL:CHEMBL4741469 PubChem:162646782 antibiotic_resistance ARO:3007313 KL-L9P ARO:3007313 KL-L9P is an experimental peptide used to increase the permeability of Gram-negative bacterial membranes to enhance the entry of antibiotics such as linezolid, rifampicin, and clarithromycin. PMID:33205989 Pentamidine is an antiparasitic compound used to treat a variety of infections such as African trypanosomiasis and leishamaniasis. It has also been shown to increase Gram-negative membrane permeability and enhance the entry of certain antibiotics. Pentamidine combined with linezolid had significant synergistic antibacterial effects against carbapenem-resistant Enterobacteriaceae pentamidine. The antimicrobial disrupts the outer membranes, dissipates the membrane potentials, and devitalizes the efflux pumps of CRE, thereby facilitating the intracellular accumulation of linezolid and reactive oxygen species (ROS), which ultimately kills the bacteria. CAS:100-33-4 ChEBI:45081 ChEMBL:CHEMBL55 PubChem:4735 Nebupent Pentam antibiotic_resistance ARO:3007314 pentamidine ARO:3007314 Pentamidine is an antiparasitic compound used to treat a variety of infections such as African trypanosomiasis and leishamaniasis. It has also been shown to increase Gram-negative membrane permeability and enhance the entry of certain antibiotics. Pentamidine combined with linezolid had significant synergistic antibacterial effects against carbapenem-resistant Enterobacteriaceae pentamidine. The antimicrobial disrupts the outer membranes, dissipates the membrane potentials, and devitalizes the efflux pumps of CRE, thereby facilitating the intracellular accumulation of linezolid and reactive oxygen species (ROS), which ultimately kills the bacteria. PMID:28263303 MAC-0568743 is an experimental compound that has been shown to increase the permeability of Gram-negative membranes and enhance the entry of large-scaffold antibiotics. PubChem:2977394 antibiotic_resistance ARO:3007315 MAC-0568743 ARO:3007315 MAC-0568743 is an experimental compound that has been shown to increase the permeability of Gram-negative membranes and enhance the entry of large-scaffold antibiotics. PMID:33974796 Liproxstatin-1 is a ferroptosis inhibitor that has been shown to increase the permeability of Gram-negative membranes and enhance the entry of large-scaffold antibiotics. ChEBI:173097 ChEMBL:CHEMBL2094750 PubChem:135735917 antibiotic_resistance ARO:3007316 liproxstatin-1 ARO:3007316 Liproxstatin-1 is a ferroptosis inhibitor that has been shown to increase the permeability of Gram-negative membranes and enhance the entry of large-scaffold antibiotics. PMID:33974796 D-LANA-14 is a d-lysine conjugated aliphatic norspermidine analogue that has been shown to increase the permeability of Gram-negative membranes and enhance the entry of antibiotics. It is also able to inhibit the formation of bacterial biofilms. PubChem:140787320 antibiotic_resistance ARO:3007317 D-LANA14 ARO:3007317 D-LANA-14 is a d-lysine conjugated aliphatic norspermidine analogue that has been shown to increase the permeability of Gram-negative membranes and enhance the entry of antibiotics. It is also able to inhibit the formation of bacterial biofilms. PMID:28225264 PMID:31646866 Metformin is a first-line medication for type 2 diabetes. It has been shown to increase Gram-negative membrane permeability and enhance the entry of certain antibiotics, such as tetracyclines, beta-lactams, and rifampicin. Metformin is also able to inhibit antibiotic efflux pumps such as AcrAB-TolC and MdtK. CAS:657-24-9 ChEBI:6801 ChEMBL:CHEMBL1431 PubChem:4091 Glucophage antibiotic_resistance ARO:3007318 metformin ARO:3007318 Metformin is a first-line medication for type 2 diabetes. It has been shown to increase Gram-negative membrane permeability and enhance the entry of certain antibiotics, such as tetracyclines, beta-lactams, and rifampicin. Metformin is also able to inhibit antibiotic efflux pumps such as AcrAB-TolC and MdtK. PMID:32596101 PMID:34007223 Bicarbonate is an ion capable of increasing bacterial membrane permeability by altering the proton motive force. This enhances the entry of antibiotics. CAS:71-52-3 ChEBI:17544 ChEMBL:CHEMBL1161632 PubChem:769 antibiotic_resistance ARO:3007319 bicarbonate ARO:3007319 Bicarbonate is an ion capable of increasing bacterial membrane permeability by altering the proton motive force. This enhances the entry of antibiotics. PMID:29264917 PMID:32898415 Phenylalanine-arginine beta-naphthylamide is a widely-used experimental efflux pump inhibitor. It has also been shown to increase Gram-negative membrane permeability and enhance the entry of antibiotics, even in efflux pump deficient strains. It is also able to inhibit the formation of bacterial biofilms and disrupt quorum sensing. ChEMBL:CHEMBL56252 PubChem:443301 antibiotic_resistance ARO:3007320 phenylalanine-arginine beta-naphthylamide ARO:3007320 Phenylalanine-arginine beta-naphthylamide is a widely-used experimental efflux pump inhibitor. It has also been shown to increase Gram-negative membrane permeability and enhance the entry of antibiotics, even in efflux pump deficient strains. It is also able to inhibit the formation of bacterial biofilms and disrupt quorum sensing. PMID:23544160 PMID:33889361 Compounds which inhibit the removal of antibiotics by the tetK efflux pump. antibiotic_resistance ARO:3007321 inhibitors of tetK efflux pump ARO:3007321 Compounds which inhibit the removal of antibiotics by the AcrAB-TolC efflux pump. antibiotic_resistance ARO:3007322 inhibitors of AcrAB-TolC efflux pump ARO:3007322 Compounds which inhibit the removal of antibiotics by the MdeA efflux pump. antibiotic_resistance ARO:3007323 inhibitors of MdeA efflux pump ARO:3007323 Compounds which inhibit the removal of antibiotics by the Rv1258c (Tap) efflux pump. antibiotic_resistance ARO:3007324 inhibitors of Rv1258c efflux pump ARO:3007324 Compounds which inhibit the removal of antibiotics by the NorA efflux pump. antibiotic_resistance ARO:3007325 inhibitors of NorA efflux pump ARO:3007325 Compounds which inhibit the removal of antibiotics by the CmeABC efflux pump. antibiotic_resistance ARO:3007326 inhibitors of CmeABC efflux pump ARO:3007326 Compounds which inhibit the removal of antibiotics by the MexAB-OprM efflux pump. antibiotic_resistance ARO:3007327 inhibitors of MexAB-OprM efflux pump ARO:3007327 Compounds which inhibit the removal of antibiotics by the MdtK efflux pump. antibiotic_resistance ARO:3007328 inhibitors of MdtK efflux pump ARO:3007328 Baicalin is a flavonoid compound that is able to inhibit the activity of tetK and MsrA antibiotic efflux pumps. It is also able to inhibit the formation of bacterial biofilms and disrupt quorum sensing. CAS:21967-41-9 ChEBI:2981 ChEMBL:CHEMBL485818 PubChem:5281605 baicalein antibiotic_resistance ARO:3007329 baicalin ARO:3007329 Baicalin is a flavonoid compound that is able to inhibit the activity of tetK and MsrA antibiotic efflux pumps. It is also able to inhibit the formation of bacterial biofilms and disrupt quorum sensing. PMID:28453568 PMID:31921008 Reserpine is an alkaloid compound that is able to inhibit the activity of the AcrAB-TolC antibiotic efflux system. CAS:50-55-5 ChEBI:28487 ChEMBL:CHEMBL772 PubChem:5770 antibiotic_resistance ARO:3007330 reserpine ARO:3007330 Reserpine is an alkaloid compound that is able to inhibit the activity of the AcrAB-TolC antibiotic efflux system. PMID:31397441 Piperine is an alkaloid compound that is able to inhibit the activity of NorA, MdeA, and Rv1258c (Tap) antibiotic efflux pumps. CAS:94-62-2 ChEBI:28821 ChEMBL:CHEMBL43185 PubChem:638024 antibiotic_resistance ARO:3007331 piperine ARO:3007331 Piperine is an alkaloid compound that is able to inhibit the activity of NorA, MdeA, and Rv1258c (Tap) antibiotic efflux pumps. PMID:18848780 PMID:21680766 Piperidine is an alkaloid compound that is able to inhibit the activity of the NorA antibiotic efflux pump. CAS:110-89-4 ChEBI:18049 ChEMBL:CHEMBL15487 PubChem:8082 antibiotic_resistance ARO:3007332 piperidine ARO:3007332 Piperidine is an alkaloid compound that is able to inhibit the activity of the NorA antibiotic efflux pump. PMID:18848780 Verapamil is a blood-pressure medication that acts by blocking calcium channels. It is also able to inhibit the antibiotic efflux pump Rv1258c (Tap). CAS:52-53-9 ChEBI:9948 ChEMBL:CHEMBL6966 PubChem:2520 antibiotic_resistance ARO:3007333 verapamil ARO:3007333 Verapamil is a blood-pressure medication that acts by blocking calcium channels. It is also able to inhibit the antibiotic efflux pump Rv1258c (Tap). PMID:24532601 Norverapamil is a metabolite of verapamil that is able to inhibit the antibiotic efflux pump Rv1258c (Tap). CAS:67018-85-3 ChEBI:132050 ChEMBL:CHEMBL1298 PubChem:104972 antibiotic_resistance ARO:3007334 norverapamil ARO:3007334 Norverapamil is a metabolite of verapamil that is able to inhibit the antibiotic efflux pump Rv1258c (Tap). PMID:24532601 Chlorpromazine is a medication used to treat disorders such as schizophrenia. It is also able to inhibit bacterial antibiotic efflux pumps such as AcrAB-TolC. CAS:50-53-3 ChEBI:3647 ChEMBL:CHEMBL71 PubChem:2726 Largactil Thorazine antibiotic_resistance ARO:3007335 chlorpromazine ARO:3007335 Chlorpromazine is a medication used to treat disorders such as schizophrenia. It is also able to inhibit bacterial antibiotic efflux pumps such as AcrAB-TolC. PMID:32487753 Amitriptyline is an antidepressant used to treat a variety of conditions such as cyclic vomiting syndrome, major depressive disorder, fibromyalgia. Is is also able to inhibit bacterial antibiotic efflux pumps such as AcrAB-TolC. CAS:50-48-6 ChEBI:2666 ChEMBL:CHEMBL629 PubChem:2160 Elavil antibiotic_resistance ARO:3007336 amitriptyline ARO:3007336 Amitriptyline is an antidepressant used to treat a variety of conditions such as cyclic vomiting syndrome, major depressive disorder, fibromyalgia. Is is also able to inhibit bacterial antibiotic efflux pumps such as AcrAB-TolC. PMID:32487753 Thioridazine is a phenothiazine drug used in the treatment of schizophrenia and psychosis. It is also able to inhibit mycobacterial antibiotic efflux pumps and the formation of bacterial biofilms. CAS:50-52-2 ChEBI:9566 ChEMBL:CHEMBL479 PubChem:5452 antibiotic_resistance ARO:3007337 thioridazine ARO:3007337 Thioridazine is a phenothiazine drug used in the treatment of schizophrenia and psychosis. It is also able to inhibit mycobacterial antibiotic efflux pumps and the formation of bacterial biofilms. PMID:18836028 PMID:32312774 Biochanin A is a flavonoid compound that is able to inhibit mycobacterial antibiotic efflux pumps. CAS:491-80-5 ChEBI:17574 ChEMBL:CHEMBL131921 PubChem:5280373 antibiotic_resistance ARO:3007338 biochanin A ARO:3007338 Biochanin A is a flavonoid compound that is able to inhibit mycobacterial antibiotic efflux pumps. PMID:28964936 Phloretin is a plant-derived phenol that is able to inhibit the antibiotic efflux pump NorA. CAS:60-82-2 ChEBI:17276 ChEMBL:CHEMBL45068 PubChem:4788 antibiotic_resistance ARO:3007339 phloretin ARO:3007339 Phloretin is a plant-derived phenol that is able to inhibit the antibiotic efflux pump NorA. PMID:34833994 Epigallocatechin gallate is a flavonol that is able to inhibit antibiotic efflux pumps such as CmeABC, NorA, and tetK. CAS:989-51-5 ChEBI:4806 ChEMBL:CHEMBL297453 PubChem:65064 antibiotic_resistance ARO:3007340 epigallocatechin gallate ARO:3007340 Epigallocatechin gallate is a flavonol that is able to inhibit antibiotic efflux pumps such as CmeABC, NorA, and tetK. PMID:15155186 PMID:15643566 Hesperetin is a flavonoid compound that is able to inhibit antibiotic efflux pumps such as NorA. CAS:520-33-2 ChEBI:28230 ChEMBL:CHEMBL399121 PubChem:72281 antibiotic_resistance ARO:3007341 hesperetin ARO:3007341 Hesperetin is a flavonoid compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:34833994 Naringenin is a flavonoid compound that is able to inhibit antibiotic efflux pumps such as NorA. ChEBI:50202 ChEMBL:CHEMBL9352 PubChem:932 antibiotic_resistance ARO:3007342 naringenin ARO:3007342 Naringenin is a flavonoid compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:34833994 Sophoraflavanone G is a phytoncide derived from members of the Sophora genus. It is able to inhibit antibiotic efflux pumps such as NorA. CAS:97938-30-2 ChEBI:50209 ChEMBL:CHEMBL243148 PubChem:72936 antibiotic_resistance ARO:3007343 sophoraflavanone G ARO:3007343 Sophoraflavanone G is a phytoncide derived from members of the Sophora genus. It is able to inhibit antibiotic efflux pumps such as NorA. PMID:34833994 Chrysoeriol is a derivative of the flavone luteolin. It has been shown to inhibit antibiotic efflux pumps such as NorA. CAS:491-71-4 ChEBI:16514 ChEMBL:CHEMBL214321 PubChem:5280666 antibiotic_resistance ARO:3007344 chrysoeriol ARO:3007344 Chrysoeriol is a derivative of the flavone luteolin. It has been shown to inhibit antibiotic efflux pumps such as NorA. PMID:34833994 Sideroxylin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. ChEBI:69916 ChEMBL:CHEMBL1819400 PubChem:3083788 antibiotic_resistance ARO:3007345 sideroxylin ARO:3007345 Sideroxylin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:22814821 6-desmethylsideroxylin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. ChEBI:69918 ChEMBL:CHEMBL1819402 PubChem:56665369 antibiotic_resistance ARO:3007346 6-desmethylsideroxylin ARO:3007346 6-desmethylsideroxylin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:22814821 8-desmethylsideroxylin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. ChEBI:69917 ChEMBL:CHEMBL1819401 PubChem:44258359 antibiotic_resistance ARO:3007347 8-desmethylsideroxylin ARO:3007347 8-desmethylsideroxylin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:22814821 Diosmetin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. CAS:520-34-3 ChEBI:4630 ChEMBL:CHEMBL90568 PubChem:5281612 antibiotic_resistance ARO:3007348 diosmetin ARO:3007348 Diosmetin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:34833994 Chrysoplenetin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. CAS:603-56-5 ChEBI:3689 ChEMBL:CHEMBL33256 PubChem:5281608 antibiotic_resistance ARO:3007349 chrysosplenetin ARO:3007349 Chrysoplenetin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:34833994 Galangin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. CAS:548-83-4 ChEBI:5262 ChEMBL:CHEMBL309490 PubChem:5281616 antibiotic_resistance ARO:3007350 galangin ARO:3007350 Galangin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:34833994 Kaempferol is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. CAS:520-18-3 ChEBI:28499 ChEMBL:CHEMBL150 PubChem:5280863 antibiotic_resistance ARO:3007351 kaempferol ARO:3007351 Kaempferol is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:34833994 Kaempferol rhamnoside is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. ChEBI:184178 PubChem:44259088 antibiotic_resistance ARO:3007352 kaempferol rhamnoside ARO:3007352 Kaempferol rhamnoside is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:34833994 Myricitrin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. CAS:17912-87-7 ChEBI:70082 ChEMBL:CHEMBL454576 PubChem:5281673 antibiotic_resistance ARO:3007353 myricitrin ARO:3007353 Myricitrin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:34833994 Pendeuletin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. ChEMBL:CHEMBL165509 PubChem:5320462 antibiotic_resistance ARO:3007354 penduletin ARO:3007354 Pendeuletin is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:34833994 Tiliroside is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. ChEMBL:CHEMBL266564 PubChem:5320686 antibiotic_resistance ARO:3007355 tiliroside ARO:3007355 Tiliroside is a flavone compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:34833994 Daidzein is a flavonolignan compound found in soybeans and other legumes. It has been shown to inhibit antibiotic efflux pumps such as AcrAB-TolC and MexAB-OprM. CAS:486-66-8 ChEBI:28197 ChEMBL:CHEMBL8145 PubChem:5281708 antibiotic_resistance ARO:3007356 daidzein ARO:3007356 Daidzein is a flavonolignan compound found in soybeans and other legumes. It has been shown to inhibit antibiotic efflux pumps such as AcrAB-TolC and MexAB-OprM. PMID:34833994 Genistein is a flavonolignan compound that is able to inhibit antibiotic efflux pumps such as NorA. CAS:446-72-0 ChEBI:28088 ChEMBL:CHEMBL44 PubChem:5280961 antibiotic_resistance ARO:3007357 genistein ARO:3007357 Genistein is a flavonolignan compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:32923005 Orobol is a flavonolignan compound that is able to inhibit antibiotic efflux pumps such as NorA. CAS:480-23-9 ChEBI:69437 ChEMBL:CHEMBL241609 PubChem:5281801 antibiotic_resistance ARO:3007358 orobol ARO:3007358 Orobol is a flavonolignan compound that is able to inhibit antibiotic efflux pumps such as NorA. PMID:32923005 MBX-2319 is an experimental compound used to inhibit the AcrAB-TolC antibiotic efflux system. ChEMBL:CHEMBL3401827 PubChem:1289417 antibiotic_resistance ARO:3007359 MBX-2319 ARO:3007359 MBX-2319 is an experimental compound used to inhibit the AcrAB-TolC antibiotic efflux system. PMID:25114133 Capsaicin is a compound found in chili peppers and is used to treat nerve pain. It is also able to inhibit antibiotic efflux pumps such as NorA. CAS:404-86-4 ChEBI:3374 ChEMBL:CHEMBL294199 PubChem:1548943 antibiotic_resistance ARO:3007360 capsaicin ARO:3007360 Capsaicin is a compound found in chili peppers and is used to treat nerve pain. It is also able to inhibit antibiotic efflux pumps such as NorA. PMID:22807321 Rutin is a plant pigment that is able to inhibit bacterial biofilm formation. CAS:153-18-4 ChEBI:28527 ChEMBL:CHEMBL226335 PubChem:5280805 antibiotic_resistance ARO:3007361 rutin ARO:3007361 Rutin is a plant pigment that is able to inhibit bacterial biofilm formation. PMID:34456739 Citral is a monoterpene aldehyde derived from a variety of plant oils that is able to inhibit bacterial biofilm formation and quorum sensing. CAS:5392-40-5 ChEBI:23316 ChEMBL:CHEMBL1080997 PubChem:638011 antibiotic_resistance ARO:3007362 citral ARO:3007362 Citral is a monoterpene aldehyde derived from a variety of plant oils that is able to inhibit bacterial biofilm formation and quorum sensing. PMID:33392626 Furanone is a heterocyclic organic compound that disrupts bacterial quorum sensing. PubChem:140765 antibiotic_resistance ARO:3007363 furanone ARO:3007363 Furanone is a heterocyclic organic compound that disrupts bacterial quorum sensing. PMID:31971503 A mixture of the beta-lactam antibiotic cefepime and the beta-lactamase inhibitor tazobactam. PubChem:9567558 antibiotic_resistance ARO:3007364 cefepime-tazobactam ARO:3007364 A mixture of the beta-lactam antibiotic cefepime and the beta-lactamase inhibitor tazobactam. PMID:33716176 A mixture of the beta-lactam antibiotic cepefime and the beta-lactamase inhibitor enmetazobactam. antibiotic_resistance ARO:3007365 cefepime-enmetazobactam ARO:3007365 A mixture of the beta-lactam antibiotic cepefime and the beta-lactamase inhibitor enmetazobactam. PMID:35471043 A mixture of the beta-lactam antibiotic aztreonam and the beta-lactamase inhibitor avibactam. antibiotic_resistance ARO:3007366 aztreonam-avibactam ARO:3007366 A mixture of the beta-lactam antibiotic aztreonam and the beta-lactamase inhibitor avibactam. PMID:35760303 L-CS319 is an experimental bisthiazolidine metallo-beta-lactamase inhibitor capable of inhibiting the action of NDM-1. ChEMBL:CHEMBL4639950 PubChem:76936796 antibiotic_resistance ARO:3007367 L-CS319 ARO:3007367 L-CS319 is an experimental bisthiazolidine metallo-beta-lactamase inhibitor capable of inhibiting the action of NDM-1. PMID:27623409 FosG is a glutathione transferase that confers resistance to fosfomycin. FosG antibiotic_resistance ARO:3007368 FosG ARO:3007368 FosG is a glutathione transferase that confers resistance to fosfomycin. PMID:33199384 FosG FosH is a hydrolase that confers resistance to fosfomycin. FosH antibiotic_resistance ARO:3007369 FosH ARO:3007369 FosH is a hydrolase that confers resistance to fosfomycin. PMID:33199384 FosH FosI is a fosfomycin resistance gene. FosI antibiotic_resistance ARO:3007370 FosI ARO:3007370 FosI is a fosfomycin resistance gene. PMID:26552984 FosI FosA8 is a plasmid-located fosfomycin resistance gene. FosA8 antibiotic_resistance ARO:3007371 FosA8 ARO:3007371 FosA8 is a plasmid-located fosfomycin resistance gene. PMID:31481445 FosA8 FosBx1 is a fosfomycin resistance gene. FosBx1 antibiotic_resistance ARO:3007372 FosBx1 ARO:3007372 FosBx1 is a fosfomycin resistance gene. PMID:33199384 FosBx1 A family of subclass B3 metallo-beta-lactamases with activity against a range of beta-lactam antibiotics. antibiotic_resistance ARO:3007373 PJM beta-lactamase ARO:3007373 A family of subclass B3 metallo-beta-lactamases with activity against a range of beta-lactam antibiotics. PMID:35943258 PJM-1 is a chromosomally-encoded subclass B3 metallo-beta-lactamase found in P. japonensis confering resistance to a range of antibiotics including ampicillin, cefalotin, and cefoxitin. PJM-1 antibiotic_resistance ARO:3007374 PJM-1 ARO:3007374 PJM-1 is a chromosomally-encoded subclass B3 metallo-beta-lactamase found in P. japonensis confering resistance to a range of antibiotics including ampicillin, cefalotin, and cefoxitin. PMID:35943258 PJM-1 KPC-87 is a chromosome-encoded carbapenemase found in Klebsiella pneumonia. KPC-87 antibiotic_resistance ARO:3007375 KPC-87 ARO:3007375 KPC-87 is a chromosome-encoded carbapenemase found in Klebsiella pneumonia. PMID:36003991 KPC-87 Gentamicin X is an aminoglycoside antibiotic. It is a precursor of gentamicin C and a minor component of the gentamicin antibiotic mixture. ChEMBL:CHEMBL4465498 PubChem:15574862 gentamicin X2 antibiotic_resistance ARO:3007376 gentamicin X ARO:3007376 Gentamicin X is an aminoglycoside antibiotic. It is a precursor of gentamicin C and a minor component of the gentamicin antibiotic mixture. PMID:25641167 6'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. PubChem:15344654 antibiotic_resistance ARO:3007377 6'-N-ethylnetilmicin ARO:3007377 6'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. PMID:8385262 2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. PubChem:101649392 antibiotic_resistance ARO:3007378 2'-N-ethylnetilmicin ARO:3007378 2'-N-ethylnetilmicin is an aminoglycoside antibiotic and a derivative of netilmicin. PMID:8385262 5-episosomicin is a semisynthetic aminoglycoside antibiotic similar to sisomicin. PubChem:65453 pentisomicin antibiotic_resistance ARO:3007379 5-episisomicin ARO:3007379 5-episosomicin is a semisynthetic aminoglycoside antibiotic similar to sisomicin. PMID:697347 Resistance-conferring genetic elements encoding proteins involved in the enzymatic inactivation of aminoglycoside antibiotics through chemical modification. antibiotic_resistance ARO:3007380 aminoglycoside modifying enzyme ARO:3007380 KPC-86 is a chromosome-encoded carbapenemase found in Klebsiella pneumonia. KPC-86 antibiotic_resistance ARO:3007381 KPC-86 ARO:3007381 KPC-86 is a chromosome-encoded carbapenemase found in Klebsiella pneumonia. PMID:36003991 KPC-86 Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). ChEMBL:CHEMBL3039597 PubChem:3467 Cidomycin Garamycin Gentacycol Gentamicins Gentamicinum Gentavet antibiotic_resistance ARO:3007382 gentamicin ARO:3007382 Gentamicin is a commonly used aminoglycoside antibiotic derived from members of the Micromonospora genus of bacteria. It acts by binding the 30S ribosomal subunit, thus inhibiting protein synthesis. Gentamicin is typically used to treat Gram-negative infections of the repiratory and urinary tract, as well as infections of the bone and soft tissue. It also exhibits considerable nephrotoxicity and ototoxicity. Gentamicin is administered as a mixture of gentamicin type C (which makes about around 80% of the complex) and types A, B, and X (distributed in the remaining 20% of the complex). PMID:28507482 KPC-95 is a chromosome-encoded carbapenemase found in Klebsiella pneumonia. KPC-95 antibiotic_resistance ARO:3007383 KPC-95 ARO:3007383 KPC-95 is a chromosome-encoded carbapenemase found in Klebsiella pneumonia. PMID:35038557 KPC-95 A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate gentamicin through enzymatic acetylation, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007384 AAC(3)-I ARO:3007384 A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate gentamicin through enzymatic acetylation, thereby conferring resistance to these compounds. PMID:8385262 A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate gentamicin and tobramycin through enzymatic acetylation, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007385 AAC(3)-II ARO:3007385 A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate gentamicin and tobramycin through enzymatic acetylation, thereby conferring resistance to these compounds. PMID:8385262 A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate gentamicin, tobramycin and kanamycin through enzymatic acetylation, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007386 AAC(3)-III ARO:3007386 A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate gentamicin, tobramycin and kanamycin through enzymatic acetylation, thereby conferring resistance to these compounds. PMID:8385262 A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate gentamicin, tobramycin and apramycin through enzymatic acetylation, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007387 AAC(3)-IV ARO:3007387 A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate gentamicin, tobramycin and apramycin through enzymatic acetylation, thereby conferring resistance to these compounds. PMID:8385262 A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate gentamicin and ethylnetilmicin through enzymatic acetylation, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007388 AAC(3)-VI ARO:3007388 A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate gentamicin and ethylnetilmicin through enzymatic acetylation, thereby conferring resistance to these compounds. PMID:8385262 A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate paronomycin through enzymatic acetylation, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007389 AAC(3)-VII ARO:3007389 A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate neomycin through enzymatic acetylation, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007390 AAC(3)-VIII ARO:3007390 A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate neomycin through enzymatic acetylation, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007391 AAC(3)-IX ARO:3007391 A family of aminoglycoside 3-N-acetyltransferase enzymes which inactivate kanamycin through enzymatic acetylation, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007392 AAC(3)-X ARO:3007392 A family of aminoglycoside 2'-N-acetyltransferase enzymes which inactivate gentamicin and tobramycin through enzymatic acetylation, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007393 AAC(2')-I ARO:3007393 A family of aminoglycoside 2'-N-acetyltransferase enzymes which inactivate kasugamycin through enzymatic acetylation, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007394 AAC(2')-II ARO:3007394 A family of aminoglycoside 6'-N-acetyltransferase enzymes which inactivate amikacin and tobramycin through enzymatic acetylation, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007395 AAC(6')-I ARO:3007395 A family of aminoglycoside 6'-N-acetyltransferase enzymes which inactivate amikacin and tobramycin through enzymatic acetylation, thereby conferring resistance to these compounds. PMID:8385262 A family of aminoglycoside 6'-N-acetyltransferase enzymes which inactivate gentamicin and tobramycin through enzymatic acetylation, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007396 AAC(6')-II ARO:3007396 A family of aminoglycoside 6'-N-acetyltransferase enzymes which inactivate gentamicin and tobramycin through enzymatic acetylation, thereby conferring resistance to these compounds. PMID:8385262 SIR is a revised system for antibiotic sensitivity testing in Sweden that was proposed in 1977. The SIR system included two main changes: three sensitivity groups instead of the previous four and new breakpoints for the sensitivity groups. antibiotic_resistance ARO:3007397 Swedish Reference Group for Antibiotics (SIR) ARO:3007397 SIR is a revised system for antibiotic sensitivity testing in Sweden that was proposed in 1977. The SIR system included two main changes: three sensitivity groups instead of the previous four and new breakpoints for the sensitivity groups. DOI:10.3109/inf.1981.13.issue-2.13 The WRG is a standardized antimicrobial susceptibility testing methodology created by the Dutch Commissie Richtlijnen Gevoeligheidsbepalingen in 1981. Commissie Richtlijnen Gevoeligheidsbepalingen (CRG) Committee Guidelines Susceptibility Testing Working Group Guidelines Susceptibility Testing antibiotic_resistance ARO:3007398 Werkgroep Richtlijnen Gevoeligheidsbepalingen (WRG) ARO:3007398 The WRG is a standardized antimicrobial susceptibility testing methodology created by the Dutch Commissie Richtlijnen Gevoeligheidsbepalingen in 1981. DOI:10.1007/bf01964289 A family of aminoglycoside 6-O-nucleotidyltransferase enzymes which inactivate streptomycin by catalyzing the transfer of an AMP group from an ATP substrate, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007399 ANT(6)-I ARO:3007399 A family of aminoglycoside 6-O-nucleotidyltransferase enzymes which inactivate streptomycin by catalyzing the transfer of an AMP group from an ATP substrate, thereby conferring resistance to these compounds. PMID:20833577 PMID:8385262 A family of aminoglycoside 9-O-nucleotidyltransferase enzymes which inactivate spectinomycin by catalyzing the transfer of an AMP group from an ATP substrate, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007400 ANT(9)-I ARO:3007400 A family of aminoglycoside 9-O-nucleotidyltransferase enzymes which inactivate spectinomycin by catalyzing the transfer of an AMP group from an ATP substrate, thereby conferring resistance to these compounds. PMID:20833577 PMID:8385262 A plasmid-borne ANT(9)-I variant identified from Enterococcus faecalis. ANT(9)-Ib confers resistance to spectinomycin through enzymatic inactivation. ANT(9)-Ib antibiotic_resistance ARO:3007401 ANT(9)-Ib ARO:3007401 A plasmid-borne ANT(9)-I variant identified from Enterococcus faecalis. ANT(9)-Ib confers resistance to spectinomycin through enzymatic inactivation. PMID:1659306 ANT(9)-Ib KPC-94 is a mutated carbapenemase allele found in Klebsiella pneumoniae. KPC-94 antibiotic_resistance ARO:3007402 KPC-94 ARO:3007402 KPC-94 is a mutated carbapenemase allele found in Klebsiella pneumoniae. PMID:35038557 KPC-94 A family of aminoglycoside 4'-O-nucleotidyltransferase enzymes which inactivate amikacin, tobramycin & dibekacin by catalyzing the transfer of an AMP group from an ATP substrate, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007403 ANT(4')-I ARO:3007403 A family of aminoglycoside 4'-O-nucleotidyltransferase enzymes which inactivate amikacin & tobramycin, but not dibekacin, by catalyzing the transfer of an AMP group from an ATP substrate, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007404 ANT(4')-II ARO:3007404 A family of aminoglycoside 2''-O-nucleotidyltransferase enzymes which inactivate gentamicin, tobramycin & dibekacin by catalyzing the transfer of an AMP group from an ATP substrate, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007405 ANT(2'')-I ARO:3007405 A family of aminoglycoside 3'-O-phosphotransferase enzymes which inactivate kamamycin, neomycin & lividomycin by catalyzing the ATP-dependent phosphorylation of these antibiotics, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007406 APH(3')-I ARO:3007406 A family of aminoglycoside O-nucleotidyltransferase enzymes which inactivate streptomycin and spectinomycin by catalyzing the transfer of an AMP group from an ATP substrate, thereby conferring resistance to these compounds. These enzymes modify the 3''-hydroxyl position of streptomycin and the 9-hydroxyl position of spectinomycin. antibiotic_resistance ARO:3007407 ANT(3'')-I ARO:3007407 A family of aminoglycoside 3'-O-phosphotransferase enzymes which inactivate kanamycin, neomycin, paromomycin and butirosin by catalyzing the ATP-dependent phosphorylation of these antibiotics, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007408 APH(3')-II ARO:3007408 A family of aminoglycoside 3'-O-phosphotransferase enzymes which inactivate kanamycin, neomycin, paromomycin, butirosin and lividomycin by catalyzing the ATP-dependent phosphorylation of these antibiotics, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007409 APH(3')-III ARO:3007409 A family of aminoglycoside 3'-O-phosphotransferase enzymes which inactivate kanamycin, neomycin, paromomycin, ribostamycin and butirosin by catalyzing the ATP-dependent phosphorylation of these antibiotics, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007410 APH(3')-IV ARO:3007410 A family of aminoglycoside 3'-O-phosphotransferase enzymes which inactivate neomycin, paromomycin and ribostamycin by catalyzing the ATP-dependent phosphorylation of these antibiotics, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007411 APH(3')-V ARO:3007411 A family of aminoglycoside 3'-O-phosphotransferase enzymes which inactivate kanamycin, neomycin, paromomycin, ribostamycin and butirosin, as well as amikacin and isepomicin, by catalyzing the ATP-dependent phosphorylation of these antibiotics, thereby conferring resistance to these compounds. antibiotic_resistance ARO:3007412 APH(3')-VI ARO:3007412 A family of aminoglycoside 3'-O-phosphotransferase enzymes which inactivate kanamycin and neomycin by catalyzing the ATP-dependent phosphorylation of these antibiotics, thereby conferring resistance to these compounds. It is also possible to observe low-level sub-breakpoint amikacin resistance dependent on testing standards and breakpoint criteria. antibiotic_resistance ARO:3007413 APH(3')-VII ARO:3007413 A family of aminoglycoside 3''-O-phosphotransferase enzymes which inactivate streptomycin by catalyzing the ATP-dependent phosphorylation of the 3''-hydroxyl group, thereby conferring resistance. antibiotic_resistance ARO:3007414 APH(3'')-I ARO:3007414 A family of aminoglycoside 6-O-phosphotransferase enzymes which inactivate streptomycin by catalyzing the ATP-dependent phosphorylation of the 6-hydroxyl group, thereby conferring resistance. antibiotic_resistance ARO:3007415 APH(6)-I ARO:3007415 A family of aminoglycoside 9-O-phosphotransferase enzymes which inactivate spectinomycin by catalyzing the ATP-dependent phosphorylation of the 9-hydroxyl group, thereby conferring resistance. antibiotic_resistance ARO:3007416 APH(9)-I ARO:3007416 A family of aminoglycoside 7''-O-phosphotransferase enzymes which inactivate hygromycin by catalyzing the ATP-dependent phosphorylation of the 7''-hydroxyl group, thereby conferring resistance. antibiotic_resistance ARO:3007417 APH(7'')-I ARO:3007417 A family of aminoglycoside 4-O-phosphotransferase enzymes which inactivate hygromycin by catalyzing the ATP-dependent phosphorylation of the 4-hydroxyl group, thereby conferring resistance. antibiotic_resistance ARO:3007418 APH(4)-I ARO:3007418 Bifunctional aminoglycoside-inactivating enzymes composed of two separate functional domains. These proteins possess activity from both enzyme components, thereby conferring resistance to the combination of antibiotics from both domains, and may include acetylation, phosphorylation or nucleotidylation activity. antibiotic_resistance ARO:3007419 aminoglycoside bifunctional resistance protein ARO:3007419 LamB is a maltoporin that negatively regulates antibiotic resistance. Knockout strains of lamB are shown to exhibit higher levels of resistance than wild-type strains. Mutations in the lamB gene of Klebsiella are associated with resistance to ceftazidime-avibactam. Kpne_lamB_CZA antibiotic_resistance ARO:3007420 Klebsiella pneumoniae lamB with mutations conferring resistance to ceftazidime-avibactam ARO:3007420 LamB is a maltoporin that negatively regulates antibiotic resistance. Knockout strains of lamB are shown to exhibit higher levels of resistance than wild-type strains. Mutations in the lamB gene of Klebsiella are associated with resistance to ceftazidime-avibactam. PMID:34551677 Kpne_lamB_CZA Mutant PBP3 in Klebsiella pneumoniae conferring resistance to ceftazidime-avibactam. Kpne_PBP3_BLA antibiotic_resistance ARO:3007421 Klebsiella pneumoniae PBP3 mutants conferring resistance to ceftazidime-avibactam ARO:3007421 Mutant PBP3 in Klebsiella pneumoniae conferring resistance to ceftazidime-avibactam. PMID:34551677 Kpne_PBP3_BLA A combination of the beta-lactam antibiotic ceftaroline and the beta-lactamase inhibitor avibactam. antibiotic_resistance ARO:3007422 ceftaroline-avibactam ARO:3007422 A combination of the beta-lactam antibiotic ceftaroline and the beta-lactamase inhibitor avibactam. PMID:22441578 Mutant PBP3 in E. coli conferring resistance to beta-lactams, including beta-lactam/beta-lactamase inhibitor combinations. Ecol_PBP3_BLA antibiotic_resistance ARO:3007423 Escherichia coli PBP3 mutants conferring resistance to beta-lactam antibiotics ARO:3007423 Mutant PBP3 in E. coli conferring resistance to beta-lactams, including beta-lactam/beta-lactamase inhibitor combinations. PMID:25634992 PMID:28559260 Ecol_PBP3_BLA Resistance via uptake of host nutrients to bypass antibiotic mechanism. antibiotic_resistance ARO:3007424 resistance by host-dependent nutrient acquisition ARO:3007424 Resistance via uptake of host nutrients to bypass antibiotic mechanism. PMID:36450721 Proteins involved in the uptake of host-nutrients to bypass antibiotic resistance mechanisms. antibiotic_resistance ARO:3007425 protein(s) conferring resistance via host-dependent nutrient acquisition ARO:3007425 ECF transporter S component genes involved in host nutrient uptake. antibiotic_resistance ARO:3007426 ECF transporter S component ARO:3007426 ECF transporter S component genes involved in host nutrient uptake. PMID:36450721 ThfT is an ECF transporter S component that expands the substrate profile of endogenous ECF transporters to include folate biosynthesis end products. It confers resistance to the folate synthesis inhibitor sulfamethoxazole by allowing uptake of host folate. ThfT antibiotic_resistance ARO:3007427 ThfT ARO:3007427 ThfT is an ECF transporter S component that expands the substrate profile of endogenous ECF transporters to include folate biosynthesis end products. It confers resistance to the folate synthesis inhibitor sulfamethoxazole by allowing uptake of host folate. PMID:36450721 ThfT Operon or gene clusters confering resistance to polymyxin antibiotics. antibiotic_resistance ARO:3007428 polymyxin resistance operon ARO:3007428 Operon or gene clusters confering resistance to polymyxin antibiotics. PMID:25068415 Various genes and proteins involved in intrinsic polymyxin resistance operons. antibiotic_resistance ARO:3007429 gene(s) or protein(s) associated with polymyxin resistance operon ARO:3007429 Glycyl carrier proteins associated with polymixin resistance operons. antibiotic_resistance ARO:3007430 alm glycyl carrier protein ARO:3007430 Glycyl carrier proteins associated with polymixin resistance operons. PMID:25068415 almF is a glycine carrier protein associated with the almEFG operon in Vibrio cholerae. It is activated by almE and carries the glycyl molecule later added to lipid A by almG. almF antibiotic_resistance ARO:3007431 almF ARO:3007431 almF is a glycine carrier protein associated with the almEFG operon in Vibrio cholerae. It is activated by almE and carries the glycyl molecule later added to lipid A by almG. PMID:25068415 almF Glycyl transferase associated with polymyxin resistance operons not interacting with lipid A. antibiotic_resistance ARO:3007432 alm glycyltransferase ARO:3007432 Glycyl transferase associated with polymyxin resistance operons not interacting with lipid A. PMID:25068415 almE is a glycyltransferase found in Vibrio cholerae that transfers glycine to the carrier protein almF. almE is part of the almEFG polymyxin resistance operon. almE antibiotic_resistance ARO:3007433 almE ARO:3007433 almE is a glycyltransferase found in Vibrio cholerae that transfers glycine to the carrier protein almF. almE is part of the almEFG polymyxin resistance operon. PMID:25068415 almE The almEFG operon is responsible for glycylation of lipid A as a mechanism of colistin resistance in Vibrio cholerae. Its mechanism involves transfer of a glycyl molecule to the carrier protein almF by almE followed by glycylation of lipid A by almG. almEFG antibiotic_resistance ARO:3007434 almEFG ARO:3007434 The almEFG operon is responsible for glycylation of lipid A as a mechanism of colistin resistance in Vibrio cholerae. Its mechanism involves transfer of a glycyl molecule to the carrier protein almF by almE followed by glycylation of lipid A by almG. PMID:25068415 almEFG WUS-1 is a WUS beta-lactamase. WUS-1 antibiotic_resistance ARO:3007435 WUS-1 ARO:3007435 WUS-1 is a WUS beta-lactamase. PMID:36532482 WUS-1 KPC-96 is a KPC beta-lactamase. KPC-96 antibiotic_resistance ARO:3007436 KPC-96 ARO:3007436 KPC-96 EBR-5 is an EBR beta-lactamase. EBR-5 antibiotic_resistance ARO:3007437 EBR-5 ARO:3007437 EBR-5 is an EBR beta-lactamase. PMID:36719228 EBR-5 LAQ-1 beta lactamase is a class C beta lactamase. LAQ-1 antibiotic_resistance ARO:3007438 LAQ-1 ARO:3007438 LAQ-1 beta lactamase is a class C beta lactamase. PMID:36504772 LAQ-1 SSA beta-lactamases are a family of Class A beta-lactamases. antibiotic_resistance ARO:3007439 SSA beta-lactamase ARO:3007439 SSA beta-lactamases are a family of Class A beta-lactamases. PMID:36626997 WUS is a family of the metallo-beta-lactamases. antibiotic_resistance ARO:3007440 WUS beta-lactamase ARO:3007440 WUS is a family of the metallo-beta-lactamases. PMID:36532482 LAQ is a class C beta lactamase. antibiotic_resistance ARO:3007441 LAQ beta lactamase ARO:3007441 LAQ is a class C beta lactamase. PMID:36504772 SSA is an SSA beta lactamase. SSA antibiotic_resistance ARO:3007442 SSA ARO:3007442 SSA is an SSA beta lactamase. PMID:36626997 SSA NDM-44 is a subclass B1 NDM metallo-beta-lactamase. NDM-44 antibiotic_resistance ARO:3007443 NDM-44 ARO:3007443 NDM-44 NDM-45 is a NDM class B metallo beta-lactamase. NDM-45 antibiotic_resistance ARO:3007444 NDM-45 ARO:3007444 NDM-45 NDM-46 is an NDM metallo-beta-lactamase. NDM-46 antibiotic_resistance ARO:3007445 NDM-46 ARO:3007445 NDM-46 KPC-100 is an inhibitor-resistant carbapenem-hydrolyzing KPC beta-lactamase. KPC-100 antibiotic_resistance ARO:3007446 KPC-100 ARO:3007446 KPC-100 NDM-47 is a NDM metallo-beta-lactamase. NDM-47 antibiotic_resistance ARO:3007447 NDM-47 ARO:3007447 NDM-47 TEM-246 is a class A TEM beta-lactamase found in Neisseria gonorrhoeae. TEM-246 antibiotic_resistance ARO:3007448 TEM-246 ARO:3007448 TEM-246 KPC-97 is a KPC class A beta-lactamase. KPC-97 antibiotic_resistance ARO:3007449 KPC-97 ARO:3007449 KPC-97 KPC-98 is a KPC beta-lactamase. KPC-98 antibiotic_resistance ARO:3007450 KPC-98 ARO:3007450 KPC-98 TEM-247 is a TEM class A beta-lactamase. TEM-247 antibiotic_resistance ARO:3007451 TEM-247 ARO:3007451 TEM-247 KPC-99 is a KPC class A beta-lactamase. KPC-99 antibiotic_resistance ARO:3007452 KPC-99 ARO:3007452 KPC-99 TEM-244 is a TEM beta-lactamase. TEM-244 antibiotic_resistance ARO:3007453 TEM-244 ARO:3007453 TEM-244 TEM-245 is a TEM class A beta-lactamase. TEM-245 antibiotic_resistance ARO:3007454 TEM-245 ARO:3007454 TEM-245 Cethromycin is a ketolide (macrolide) antibiotic, with a similar mechanism to telithromycin, with activity against selected gram-positive, gram-negative, atypical bacteria, and even designed for tularemia, plague, and anthrax prophylaxis. CAS:205110-48-1 ChEBI:29506 ChEMBL:CHEMBL3989904 PubChem:447451 antibiotic_resistance ARO:3007455 cethromycin ARO:3007455 Cethromycin is a ketolide (macrolide) antibiotic, with a similar mechanism to telithromycin, with activity against selected gram-positive, gram-negative, atypical bacteria, and even designed for tularemia, plague, and anthrax prophylaxis. PMID:37081393 dfrL is a gene encoding a trimethoprim-resistant dihydrofolate reductase (DHFR) identified in Staphylococcus aureus. dfrL antibiotic_resistance ARO:3007456 dfrL ARO:3007456 dfrL is a gene encoding a trimethoprim-resistant dihydrofolate reductase (DHFR) identified in Staphylococcus aureus. PMID:36935372 dfrL Carrimycin is a macrolide antibiotic produced by genetically engineered Streptomyces spiramyceticus and may be active against some Gram-positive bacteria and Mycobacterium tuberculosis. ChEMBL:CHEMBL4650385 PubChem:101485377 bitespiramycin antibiotic_resistance ARO:3007457 carrimycin ARO:3007457 Carrimycin is a macrolide antibiotic produced by genetically engineered Streptomyces spiramyceticus and may be active against some Gram-positive bacteria and Mycobacterium tuberculosis. PMID:37113529 Cefovecin is a cephalosporin antibiotic used for the treatment of skin infections in cats and dogs. It is used for the treatment of skin infections caused by Pasturella multocida in cats, and Staphylococcus in dogs. ChEMBL:CHEMBL2110625 PubChem:6336480 antibiotic_resistance ARO:3007458 cefovecin ARO:3007458 Cefovecin is a cephalosporin antibiotic used for the treatment of skin infections in cats and dogs. It is used for the treatment of skin infections caused by Pasturella multocida in cats, and Staphylococcus in dogs. PMID:37107106 EstT is a gene encoding for a serine-dependent macrolide alpha/beta-hydrolase. EstT antibiotic_resistance ARO:3007459 EstT ARO:3007459 EstT is a gene encoding for a serine-dependent macrolide alpha/beta-hydrolase. PMID:36791107 EstT IMP-91 is an IMP beta-lactamase. IMP-91 antibiotic_resistance ARO:3007460 IMP-91 ARO:3007460 IMP-91 is an IMP beta-lactamase. PMID:37092959 IMP-91 IMP-96 is an IMP beta-lactamase. IMP-96 antibiotic_resistance ARO:3007461 IMP-96 ARO:3007461 IMP-96 is an IMP beta-lactamase. PMID:37092959 IMP-96 IMP-92 is an IMP beta-lactamase. IMP-92 antibiotic_resistance ARO:3007462 IMP-92 ARO:3007462 IMP-92 IMP-93 is an IMP beta-lactamase. IMP-93 antibiotic_resistance ARO:3007463 IMP-93 ARO:3007463 IMP-93 IMP-94 is an IMP beta-lactamase. IMP-94 antibiotic_resistance ARO:3007464 IMP-94 ARO:3007464 IMP-94 IMP-95 is an IMP beta-lactamase. IMP-95 antibiotic_resistance ARO:3007465 IMP-95 ARO:3007465 IMP-95 BP2 is a novel beta-lactam-derived beta-lactamase inhibitor, efficacious when co-administered with meropenem in K. pneumoniae. antibiotic_resistance ARO:3007466 BP2 ARO:3007466 BP2 is a novel beta-lactam-derived beta-lactamase inhibitor, efficacious when co-administered with meropenem in K. pneumoniae. PMID:37106995 SUL-DUR or sulbactam-durlobactam (formerly ETX2514SUL) is a novel beta-lactam-beta-lactamase inhibitor designed specifically for the treatment of carbapenem-resistant Acinetobacter baumannii (CRAB). ETX2514SUL antibiotic_resistance ARO:3007467 sulbactam-durlobactam ARO:3007467 SUL-DUR or sulbactam-durlobactam (formerly ETX2514SUL) is a novel beta-lactam-beta-lactamase inhibitor designed specifically for the treatment of carbapenem-resistant Acinetobacter baumannii (CRAB). PMID:37052117 Sulfanilamide is a sulfonamide anti-infective used to treat vulvovaginal candidiasis caused by Candida albicans. CAS:63-74-1 ChEBI:45373 ChEMBL:CHEMBL21 PubChem:5333 antibiotic_resistance ARO:3007468 sulfanilamide ARO:3007468 Sulfanilamide is a sulfonamide anti-infective used to treat vulvovaginal candidiasis caused by Candida albicans. PMID:37081146 Sulfamerazine is a sulfonamide anti-infective used to treat bacterial infections, such as bronchitis, prostatitis, and urinary tract infections. CAS:127-79-7 ChEBI:102130 ChEMBL:CHEMBL438 PubChem:5325 antibiotic_resistance ARO:3007469 sulfamerazine ARO:3007469 Sulfamerazine is a sulfonamide anti-infective used to treat bacterial infections, such as bronchitis, prostatitis, and urinary tract infections. PMID:37081146 IND-17 is an IND beta-lactamase and confers resistance to ampicillin, nitrocefin, cefazolin, cefuroxime, ceftazidime, imipenem, meropenem in Chryseobacterium spp. IND-17 antibiotic_resistance ARO:3007470 IND-17 ARO:3007470 IND-17 is an IND beta-lactamase and confers resistance to ampicillin, nitrocefin, cefazolin, cefuroxime, ceftazidime, imipenem, meropenem in Chryseobacterium spp. PMID:37047008 IND-17 Narasin is polyether ionophore antibiotic. It is a derivative of salinomycin with an additional methyl group. Narasin is produced by fermentation of a strain of Streptomyces aureofaciens. CAS:55134-13-9 ChEBI:183815 ChEMBL:CHEMBL2104423 PubChem:65452 antibiotic_resistance ARO:3007471 narasin ARO:3007471 Narasin is polyether ionophore antibiotic. It is a derivative of salinomycin with an additional methyl group. Narasin is produced by fermentation of a strain of Streptomyces aureofaciens. PMID:37119567 Tilmicosin is a macrolide antibiotic used for livestock and poultry synthesized from tylomycin. It is mainly used to treat common bacterial infections and diseases caused by mycoplasma infection in livestock and poultry breeding. Tilmicosin has broad-spectrum antibacterial properties and has a strong inhibitory effect on most Gram positive and negative bacteria. CAS:108050-54-0 ChEBI:195409 ChEMBL:CHEMBL1908333 PubChem:5282521 antibiotic_resistance ARO:3007472 tilmicosin ARO:3007472 Tilmicosin is a macrolide antibiotic used for livestock and poultry synthesized from tylomycin. It is mainly used to treat common bacterial infections and diseases caused by mycoplasma infection in livestock and poultry breeding. Tilmicosin has broad-spectrum antibacterial properties and has a strong inhibitory effect on most Gram positive and negative bacteria. PMID:37110187 Amino acid substitution mutations in Mycobacterium avium gyrA observed to confer resistance to fluoroquinolone antibiotics. Mavi_gyrA_FLO antibiotic_resistance ARO:3007473 Mycobacterium avium gyrA with mutation conferring resistance to fluoroquinolone ARO:3007473 Amino acid substitution mutations in Mycobacterium avium gyrA observed to confer resistance to fluoroquinolone antibiotics. PMID:37067420 Mavi_gyrA_FLO Contezolid is an oxazolidinone antimicrobial agent newly approved for treatment of multidrug-resistant (MDR) Gram-positive bacterial infections, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci. ChEMBL:CHEMBL3287379 PubChem:25184541 antibiotic_resistance ARO:3007474 contezolid ARO:3007474 Contezolid is an oxazolidinone antimicrobial agent newly approved for treatment of multidrug-resistant (MDR) Gram-positive bacterial infections, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci. PMID:36992830 Cefcapene is a third-generation cephalosporin in the beta-lactam class of antibiotics used to manage and treat gram-negative and gram-positive bacterial infections. CAS:135889-00-8 ChEBI:131729 ChEMBL:CHEMBL582912 PubChem:6436055 antibiotic_resistance ARO:3007475 cefcapene ARO:3007475 Cefcapene is a third-generation cephalosporin in the beta-lactam class of antibiotics used to manage and treat gram-negative and gram-positive bacterial infections. PMID:36872372 Mutations to the ATPase subunit C atpE gene, which is involved with the production of ATP, confer resistance to bedaquiline by altering the antibiotic's target. Mabs_atpE_BDQ antibiotic_resistance ARO:3007476 Mycobacterium abscessus atpE with mutation conferring resistance to bedaquiline ARO:3007476 Mutations to the ATPase subunit C atpE gene, which is involved with the production of ATP, confer resistance to bedaquiline by altering the antibiotic's target. PMID:36988496 Mabs_atpE_BDQ ATP synthase enzymes, specifically subunit C, resistant to diarylquinolone antibiotics including Bedaquiline. Mutations in ATP synthase confer antibiotic resistance by disrupting binding and blocking of ATP synthase reactions by Bedaquiline. antibiotic_resistance ARO:3007477 antibiotic resistant ATP synthase ARO:3007477 ATP synthase enzymes, specifically subunit C, resistant to diarylquinolone antibiotics including Bedaquiline. Mutations in ATP synthase confer antibiotic resistance by disrupting binding and blocking of ATP synthase reactions by Bedaquiline. PMID:36988496 Darobactin A, isolated from Photorhabdus bacteria, contains a macrocyclic peptide-based ring system and exhibits selective antibiotic activity against Gram-negative pathogens in both in vitro and animal infection models and functions. PubChem:155899183 antibiotic_resistance ARO:3007478 darobactin A ARO:3007478 Darobactin A, isolated from Photorhabdus bacteria, contains a macrocyclic peptide-based ring system and exhibits selective antibiotic activity against Gram-negative pathogens in both in vitro and animal infection models and functions. PMID:35926121 Caprazamycin is a potent anti-mycobacterial liponucleoside antibiotics isolated from Streptomyces sp. PubChem:11332272 antibiotic_resistance ARO:3007479 caprazamycin ARO:3007479 Caprazamycin is a potent anti-mycobacterial liponucleoside antibiotics isolated from Streptomyces sp. PMID:36697788 TBI-223 is a novel oxazolidinone with potentially reduced myelosuppression, compared to linezolid. TBI-223 may be considered an additional treatment against MRSA infections and potentially other Gram-positive bacteria in humans. ChEMBL:CHEMBL5201490 PubChem:126494519 antibiotic_resistance ARO:3007480 TBI-223 ARO:3007480 TBI-223 is a novel oxazolidinone with potentially reduced myelosuppression, compared to linezolid. TBI-223 may be considered an additional treatment against MRSA infections and potentially other Gram-positive bacteria in humans. PMID:36106881 Pseudouridimycin is a nucleoside analogue inhibitor discovered from the soil bacterium Streptomyces sp. which has proven to be effective against multidrug-resistant S. pyogenes. ChEBI:199549 ChEMBL:CHEMBL5170055 PubChem:72792467 antibiotic_resistance ARO:3007481 pseudouridimycin ARO:3007481 Pseudouridimycin is a nucleoside analogue inhibitor discovered from the soil bacterium Streptomyces sp. which has proven to be effective against multidrug-resistant S. pyogenes. PMID:36873015 RAD beta-lactamases are a class D beta-lactamase first identified in Riemerella anatipestifer. antibiotic_resistance ARO:3007482 RAD beta-lactamase ARO:3007482 RAD-1 is a class D RAD beta-lactamase found in Riemerella anatipestifer. RAD-1 antibiotic_resistance ARO:3007483 RAD-1 ARO:3007483 RAD-1 is a class D RAD beta-lactamase found in Riemerella anatipestifer. PMID:36883515 RAD-1 Monensin is an ionophore antibiotic isolated from Streptomyces cinnamonensis with very strong antibacterial and antiparasitic effects. ChEMBL:CHEMBL256105 PubChem:441145 antibiotic_resistance ARO:3007484 monensin ARO:3007484 Monensin is an ionophore antibiotic isolated from Streptomyces cinnamonensis with very strong antibacterial and antiparasitic effects. PMID:37219624 Nigericin is an antibiotic derived from Streptomyces hygroscopicus. It is described as a potassium ionophore, which facilitates H+/K+ anti-port across cell membranes, thereby activating NLRP3 by causing potassium efflux. CAS:28380-24-7 ChEBI:7569 ChEMBL:CHEMBL405862 PubChem:34230 antibiotic_resistance ARO:3007485 nigericin ARO:3007485 Nigericin is an antibiotic derived from Streptomyces hygroscopicus. It is described as a potassium ionophore, which facilitates H+/K+ anti-port across cell membranes, thereby activating NLRP3 by causing potassium efflux. PMID:37247906 Wychimicins are spirotetronates with activity against methicillin-resistant Staphylococcus aureus. antibiotic_resistance ARO:3007486 wychimicin ARO:3007486 Wychimicins are spirotetronates with activity against methicillin-resistant Staphylococcus aureus. PMID:36071214 Wychimicin A is a spirotetronate polyketides from Actinocrispum wychmicini MI503-A4. PubChem:165412942 antibiotic_resistance ARO:3007487 wychimicin A ARO:3007487 Wychimicin A is a spirotetronate polyketides from Actinocrispum wychmicini MI503-A4. PMID:36071214 Wychimicin C is a spirotetronate polyketides from Actinocrispum wychmicini MI503-A4. PubChem:165412941 antibiotic_resistance ARO:3007488 wychimicin C ARO:3007488 Wychimicin C is a spirotetronate polyketides from Actinocrispum wychmicini MI503-A4. PMID:36071214 A dihydrofolate reductase and trimethoprim resistance gene found on a mega-plasmid (0.4 Mb) from a Pseudomonas putida strain. dfrB10 antibiotic_resistance ARO:3007489 dfrB10 ARO:3007489 A dihydrofolate reductase and trimethoprim resistance gene found on a mega-plasmid (0.4 Mb) from a Pseudomonas putida strain. PMID:26679251 dfrB10 A dihydrofolate reductase and trimethoprim resistance gene found in a groundwater sample at the Horonobe Underground Research laboratory in Japan in 2017, in a Betaproteobacteria sequence. dfrB11 antibiotic_resistance ARO:3007490 dfrB11 ARO:3007490 A dihydrofolate reductase and trimethoprim resistance gene found in a groundwater sample at the Horonobe Underground Research laboratory in Japan in 2017, in a Betaproteobacteria sequence. PMID:28350393 dfrB11 ampR is a regulatory gene that plays an essential role in regulating antibiotic resistance in P. aeruginosa. Mutation in ampR leads to its loss of control over blaPDC-16, allowing overexpression of blaPDC-16 and further resistance to aztreonam. Paer_ampR_ATM antibiotic_resistance ARO:3007491 Pseudomonas aeruginosa ampR with mutation conferring resistance to aztreonam ARO:3007491 ampR is a regulatory gene that plays an essential role in regulating antibiotic resistance in P. aeruginosa. Mutation in ampR leads to its loss of control over blaPDC-16, allowing overexpression of blaPDC-16 and further resistance to aztreonam. PMID:37070974 Paer_ampR_ATM A novel tetA-type efflux pump. tet(62) antibiotic_resistance ARO:3007492 tet(62) ARO:3007492 A novel tetA-type efflux pump. PMID:33515651 tet(62) A tetracycline efflux MFS Transporter from Staphylococcus aureus. tet(63) antibiotic_resistance ARO:3007493 tet(63) ARO:3007493 A tetracycline efflux MFS Transporter from Staphylococcus aureus. PMID:33247717 tet(63) A tetracycline efflux MFS Transporter from Burkholderia ubonensis. tet(64) antibiotic_resistance ARO:3007494 tet(64) ARO:3007494 A tetracycline efflux MFS Transporter from Burkholderia ubonensis. PMID:33318011 tet(64) Azoles are a group of antibiotics, particularly antifungals, that target the cytochrome P450 enzyme sterol 14alpha-demethylase, which converts lanosterol to ergosterol. They are typically fungistatic in yeasts and fungicidal in molds. The two main groups of azoles are imidazoles and triazoles. antibiotic_resistance ARO:3007495 azole antibiotic ARO:3007495 Azoles are a group of antibiotics, particularly antifungals, that target the cytochrome P450 enzyme sterol 14alpha-demethylase, which converts lanosterol to ergosterol. They are typically fungistatic in yeasts and fungicidal in molds. The two main groups of azoles are imidazoles and triazoles. PMID:32906036 Echinocandins are a group of antibiotics, particularly antifungals, that target the target glucan synthase, an enzyme involved in the cell wall biosynthesis of fungi. They typically induce adaptive mechanisms that promote resistance such as heat shock protein 90, cell wall integrity pathway, high osmolarity glycerol pathway, and chitin biosynthesis. The three main echinocandins are caspofungin, micafungin and anidulafungin. antibiotic_resistance ARO:3007496 echinocandin antibiotic ARO:3007496 Echinocandins are a group of antibiotics, particularly antifungals, that target the target glucan synthase, an enzyme involved in the cell wall biosynthesis of fungi. They typically induce adaptive mechanisms that promote resistance such as heat shock protein 90, cell wall integrity pathway, high osmolarity glycerol pathway, and chitin biosynthesis. The three main echinocandins are caspofungin, micafungin and anidulafungin. PMID:4613708 Polyenes are a group of antibiotics, particularly antifungals, that bind ergosterol, a fungal-specific sterol in the plasma membrane of fungi, causing the efflux of potassium and cell death. They were discovered in the 1930s by Richard Kuhn. They are primarily used for therapy for invasive fungal infections like invasive aspergillosis, cryptococcosis blastomycosis, etc. The two main polyenes are amphotericin B and nystatin. antibiotic_resistance ARO:3007497 polyene antibiotic ARO:3007497 Polyenes are a group of antibiotics, particularly antifungals, that bind ergosterol, a fungal-specific sterol in the plasma membrane of fungi, causing the efflux of potassium and cell death. They were discovered in the 1930s by Richard Kuhn. They are primarily used for therapy for invasive fungal infections like invasive aspergillosis, cryptococcosis blastomycosis, etc. The two main polyenes are amphotericin B and nystatin. PMID:33261213 Allylamines are a group of antibiotics, particularly antifungals, that act as squalene epoxidase and ergosterol inhibitors. They have broad-spectrum activity against pathogenic fungi, especially dermatophytes. The two main allylamines are naftifine and terbinafine. antibiotic_resistance ARO:3007498 allylamine antibiotic ARO:3007498 Allylamines are a group of antibiotics, particularly antifungals, that act as squalene epoxidase and ergosterol inhibitors. They have broad-spectrum activity against pathogenic fungi, especially dermatophytes. The two main allylamines are naftifine and terbinafine. PMID:1822408 PMID:2229523 Triazoles are a group of antibiotics, particularly antifungals, derived from azoles. Triazoles include fluconazole, itraconazole, voriconazole, posaconazole, and isavuconazole. antibiotic_resistance ARO:3007499 triazole antibiotic ARO:3007499 Triazoles are a group of antibiotics, particularly antifungals, derived from azoles. Triazoles include fluconazole, itraconazole, voriconazole, posaconazole, and isavuconazole. PMID:35547394 Imidazoles are a group of antibiotics, particularly antifungals, derived from azoles. Imidazoles include imidazole derivatives clotrimazole, ketoconazole, miconazole, econazole and oxiconazole. antibiotic_resistance ARO:3007500 imidazole antibiotic ARO:3007500 Imidazoles are a group of antibiotics, particularly antifungals, derived from azoles. Imidazoles include imidazole derivatives clotrimazole, ketoconazole, miconazole, econazole and oxiconazole. PMID:18366001 PMID:7003674 Caspofungin is an antibiotic, particularly antifungal, derived from echinocandins. It has a wide range of activity against fungi and yeasts. ChEBI:474180 ChEMBL:CHEMBL1630575 PubChem:3035406 antibiotic_resistance ARO:3007501 caspofungin ARO:3007501 Caspofungin is an antibiotic, particularly antifungal, derived from echinocandins. It has a wide range of activity against fungi and yeasts. PMID:11465873 Micafungin is an antibiotic, particularly antifungal, derived from echinocandins. It was discovered at Fujisawa Pharmaceutical Co., Ltd. It is active against most Candida species. ChEBI:600520 ChEMBL:CHEMBL457547 PubChem:477468 antibiotic_resistance ARO:3007502 micafungin ARO:3007502 Micafungin is an antibiotic, particularly antifungal, derived from echinocandins. It was discovered at Fujisawa Pharmaceutical Co., Ltd. It is active against most Candida species. PMID:18424132 Anidulafungin is an antibiotic, particularly antifungal, derived from echinocandins. It exhibits strong antifungal action against a variety of Candida spp. and Aspergillus spp., including those that are resistant to amphotericin B and triazole. ChEBI:55346 ChEMBL:CHEMBL264241 PubChem:166548 antibiotic_resistance ARO:3007503 anidulafungin ARO:3007503 Anidulafungin is an antibiotic, particularly antifungal, derived from echinocandins. It exhibits strong antifungal action against a variety of Candida spp. and Aspergillus spp., including those that are resistant to amphotericin B and triazole. PMID:15456342 Amphotericin B is an antibiotic, particularly antifungal, derived from polyene. It exhibits strong antifungal action against a variety of fungi species and is typically considered the gold standard of antifungals. CAS:1397-89-3 ChEBI:2682 ChEMBL:CHEMBL267345 PubChem:5280965 antibiotic_resistance ARO:3007504 amphotericin B ARO:3007504 Amphotericin B is an antibiotic, particularly antifungal, derived from polyene. It exhibits strong antifungal action against a variety of fungi species and is typically considered the gold standard of antifungals. PMID:33523419 Nystatin is an antibiotic, particularly antifungal, derived from polyene. Nystatin is fungistatic in vitro against Candida albicans and certain other yeast-like fungi. CAS:1400-61-9 ChEBI:7660 ChEMBL:CHEMBL450895 PubChem:6433272 antibiotic_resistance ARO:3007505 nystatin ARO:3007505 Nystatin is an antibiotic, particularly antifungal, derived from polyene. Nystatin is fungistatic in vitro against Candida albicans and certain other yeast-like fungi. PMID:4919155 Naftifine is an antibiotic, particularly antifungal, derived from Allylamine. It was discovered in 19742 at the Sandoz Research Institute in Vienna, Austria. Naftifine is fungicidal against a broad spectrum of dermatophyte fungi and provides good against Candida and Aspergillus species. CAS:65472-88-0 ChEBI:7451 ChEMBL:CHEMBL626 PubChem:47641 antibiotic_resistance ARO:3007506 naftifine ARO:3007506 Naftifine is an antibiotic, particularly antifungal, derived from Allylamine. It was discovered in 19742 at the Sandoz Research Institute in Vienna, Austria. Naftifine is fungicidal against a broad spectrum of dermatophyte fungi and provides good against Candida and Aspergillus species. PMID:1723367 PMID:18346400 Terbinafine is an antibiotic, particularly antifungal, derived from allylamine. Terbinafine is active against a broad range of fungi and yeast. It was discovered in 1983. CAS:91161-71-6 ChEBI:9448 ChEMBL:CHEMBL822 PubChem:1549008 antibiotic_resistance ARO:3007507 terbinafine ARO:3007507 Terbinafine is an antibiotic, particularly antifungal, derived from allylamine. Terbinafine is active against a broad range of fungi and yeast. It was discovered in 1983. PMID:1372222 Fluconazole is a type of triazole antibiotic, particularly antifungal. It is used for the treatment of superficial and systemic fungal infections. CAS:86386-73-4 ChEBI:46081 ChEMBL:CHEMBL106 PubChem:3365 antibiotic_resistance ARO:3007508 fluconazole ARO:3007508 Fluconazole is a type of triazole antibiotic, particularly antifungal. It is used for the treatment of superficial and systemic fungal infections. PMID:10830059 PMID:8448970 AcrA is a subunit of the AcrAB multidrug efflux system found in Shigella flexneri, which is encoded by the acrRAB operon. Sfle_acrA antibiotic_resistance ARO:3007509 Shigella flexneri acrA ARO:3007509 AcrA is a subunit of the AcrAB multidrug efflux system found in Shigella flexneri, which is encoded by the acrRAB operon. PMID:19035770 Sfle_acrA Itraconazole is a type of triazole antibiotic, particularly antifungal. It has broad spectrum activity against Candida and Malassezia species and Dermatophytes. CAS:84625-61-6 ChEBI:6076 ChEMBL:CHEMBL64391 PubChem:55283 antibiotic_resistance ARO:3007511 itraconazole ARO:3007511 Itraconazole is a type of triazole antibiotic, particularly antifungal. It has broad spectrum activity against Candida and Malassezia species and Dermatophytes. PMID:2561187 Voriconazole is a type of triazole antibiotic, particularly antifungal. It is used for the treatment of invasive aspergillosis, candidaemia, and infections caused by Candida spp. CAS:137234-62-9 ChEBI:10023 ChEMBL:CHEMBL638 PubChem:71616 antibiotic_resistance ARO:3007512 voriconazole ARO:3007512 Voriconazole is a type of triazole antibiotic, particularly antifungal. It is used for the treatment of invasive aspergillosis, candidaemia, and infections caused by Candida spp. PMID:16278744 Posaconazole is a type of triazole antibiotic, particularly antifungal. It has broad spectrum activity against Candida albicans and Aspergillus fumigatus. CAS:171228-49-2 ChEBI:64355 ChEMBL:CHEMBL1397 PubChem:468595 antibiotic_resistance ARO:3007513 posaconazole ARO:3007513 Posaconazole is a type of triazole antibiotic, particularly antifungal. It has broad spectrum activity against Candida albicans and Aspergillus fumigatus. PMID:10898669 Isavuconazole is a type of triazole antibiotic, particularly antifungal. It has activity against yeasts, dimorphic fungi, and molds. CAS:241479-67-4 ChEBI:85979 ChEMBL:CHEMBL409153 PubChem:6918485 antibiotic_resistance ARO:3007514 isavuconazole ARO:3007514 Isavuconazole is a type of triazole antibiotic, particularly antifungal. It has activity against yeasts, dimorphic fungi, and molds. PMID:16284102 ANT(9)-Ic encodes an intrinsic, chromosomal aminoglycoside nucleotidyltransferase in Brucella intermedia. ANT(9)-Ic antibiotic_resistance ARO:3007515 ANT(9)-Ic ARO:3007515 ANT(9)-Ic encodes an intrinsic, chromosomal aminoglycoside nucleotidyltransferase in Brucella intermedia. PMID:37039640 ANT(9)-Ic Clotrimazole is a type of imidazole antibiotic, particularly antifungal. It is mostly used for the treatment of tinea pedis, vulvovaginal and oropharyngeal candidiasis. It has broad activity against Candida albicans and other fungal infections. CAS:23593-75-1 ChEBI:3764 ChEMBL:CHEMBL104 PubChem:2812 antibiotic_resistance ARO:3007516 clotrimazole ARO:3007516 Clotrimazole is a type of imidazole antibiotic, particularly antifungal. It is mostly used for the treatment of tinea pedis, vulvovaginal and oropharyngeal candidiasis. It has broad activity against Candida albicans and other fungal infections. PMID:4677595 PMID:5579860 Ketoconazole is a type of imidazole antibiotic, particularly antifungal. It was one of the first available oral broad-spectrum antifungals for the treatment of systemic and superficial mycoses. CAS:65277-42-1 ChEBI:47519 ChEMBL:CHEMBL157101 PubChem:456201 antibiotic_resistance ARO:3007517 ketoconazole ARO:3007517 Ketoconazole is a type of imidazole antibiotic, particularly antifungal. It was one of the first available oral broad-spectrum antifungals for the treatment of systemic and superficial mycoses. PMID:6276122 PMID:707893 Miconazole is a type of imidazole antibiotic, particularly antifungal. It is used to treat oral and vaginal yeast infections, as well as mucosal thrush. CAS:22916-47-8 ChEBI:6923 ChEMBL:CHEMBL91 PubChem:4189 antibiotic_resistance ARO:3007518 miconazole ARO:3007518 Miconazole is a type of imidazole antibiotic, particularly antifungal. It is used to treat oral and vaginal yeast infections, as well as mucosal thrush. PMID:4563141 PMID:4919243 Econazole is a type of imidazole antibiotic, particularly antifungal. It is often used to treat tinea cruris, tinea pedis, and tinea corporis. CAS:27220-47-9 ChEBI:4754 ChEMBL:CHEMBL808 PubChem:3198 antibiotic_resistance ARO:3007519 econazole ARO:3007519 Econazole is a type of imidazole antibiotic, particularly antifungal. It is often used to treat tinea cruris, tinea pedis, and tinea corporis. PMID:1173036 PMID:4417140 Oxiconazole is a type of imidazole antibiotic, particularly antifungal. It is primarily used to treat tinea pedis, tinea cruris, tinea corporis, and tinea versicolor. CAS:64211-45-6 ChEBI:7825 ChEMBL:CHEMBL1262 PubChem:5353853 antibiotic_resistance ARO:3007520 oxiconazole ARO:3007520 Oxiconazole is a type of imidazole antibiotic, particularly antifungal. It is primarily used to treat tinea pedis, tinea cruris, tinea corporis, and tinea versicolor. PMID:583212 PMID:7037014 Flumequine is a first generation fluoroquinolone antibiotic. It is used primarily for the treatment of enteric infections in domestic species. It has been removed from clinical use and is no longer being marketed. CAS:42835-25-6 ChEBI:85267 ChEMBL:CHEMBL370252 PubChem:3374 antibiotic_resistance ARO:3007521 flumequine ARO:3007521 Flumequine is a first generation fluoroquinolone antibiotic. It is used primarily for the treatment of enteric infections in domestic species. It has been removed from clinical use and is no longer being marketed. PMID:34729090 Fungal cytochrome P450 enzymes which include mutations or other modifications to confer resistance to antifungal drug compounds. antibiotic_resistance ARO:3007522 antifungal-resistant cytochrome P450 enzyme ARO:3007522 Fungal cytochrome P450 enzymes which include mutations or other modifications to confer resistance to antifungal drug compounds. PMID:28176517 Fungal cytochrome P450 enzymes which include mutations to confer resistance to triazole-class antibiotics. antibiotic_resistance ARO:3007523 triazole-resistant fungal cytochrome P450 enzyme ARO:3007523 Fungal cytochrome P450 enzymes which include mutations to confer resistance to triazole-class antibiotics. PMID:28176517 ERG11 is a cytochrome P450 enzyme in Candida spp. Mutations in ERG11 have been shown to confer resistance to azole antibiotics including fluconazole and itraconazole. antibiotic_resistance ARO:3007524 Candida spp. ERG11 with mutations conferring resistance to azole antibiotics ARO:3007524 ERG11 is a cytochrome P450 enzyme in Candida spp. Mutations in ERG11 have been shown to confer resistance to azole antibiotics including fluconazole and itraconazole. PMID:28176517 PMID:35163552 Norvancomycin differs from vancomycin by a single methyl group and is typically used to treat methicillin-resistant Staphylococcus aureus (MRSA) ventriculitis in patients. PubChem:10419027 antibiotic_resistance ARO:3007525 norvancomycin ARO:3007525 Norvancomycin differs from vancomycin by a single methyl group and is typically used to treat methicillin-resistant Staphylococcus aureus (MRSA) ventriculitis in patients. PMID:36823383 Amino acid substitutions in ribosomal protein S5, the product of the rpsE gene, is associated with resistance to spectinomycin (SpcR). This protein is located on the 30S subunit and interacts with 16S rRNA and other proteins. Ribosomal protein S5 antibiotic_resistance ARO:3007526 spectinomycin resistant rpsE ARO:3007526 Amino acid substitutions in ribosomal protein S5, rpsE, is associated with resistance to spectinomycin (SpcR). Bsub_rpsE_SPT antibiotic_resistance ARO:3007527 Bacillus subtilis rpsE mutations conferring resistance to spectinomycin ARO:3007527 Amino acid substitutions in ribosomal protein S5, rpsE, is associated with resistance to spectinomycin (SpcR). PMID:34339280 Bsub_rpsE_SPT Gallic acid was found to enhance sulfonamides against multidrug-resistant S. suis. Gallic acid effectively disrupts the integrity and function of the cytoplasmic membrane by dissipating the proton motive force of bacteria. It regulates the expression of dihydrofolate reductase, which then inhibits tetrahydrofolate synthesis. As a result of polypharmacology, gallic acid can fully restore sulfadiazine sodium activity in the animal infection model without any drug resistances. CAS:149-91-7 ChEBI:30778 ChEMBL:CHEMBL288114 PubChem:370 antibiotic_resistance ARO:3007528 gallic acid ARO:3007528 Gallic acid was found to enhance sulfonamides against multidrug-resistant S. suis. Gallic acid effectively disrupts the integrity and function of the cytoplasmic membrane by dissipating the proton motive force of bacteria. It regulates the expression of dihydrofolate reductase, which then inhibits tetrahydrofolate synthesis. As a result of polypharmacology, gallic acid can fully restore sulfadiazine sodium activity in the animal infection model without any drug resistances. PMID:37125728 Pivmecillinam, the oral prodrug of the antimicrobial active agent mecillinam, is a bona fide agent for uncomplicated lower urinary tract infections (UTIs), because of its selectivity and effect against several species of Enterobacteriaceae. CAS:32886-97-8 ChEBI:51210 ChEMBL:CHEMBL1650818 PubChem:115163 amdinocillin pivoxil antibiotic_resistance ARO:3007529 pivmecillinam ARO:3007529 Pivmecillinam, the oral prodrug of the antimicrobial active agent mecillinam, is a bona fide agent for uncomplicated lower urinary tract infections (UTIs), because of its selectivity and effect against several species of Enterobacteriaceae. PMID:31067667 PBP2x is a penicillin-binding protein and beta-lactam resistance enzyme. Mutations can cause resistance to some beta-lactam antibiotics. antibiotic_resistance ARO:3007530 Streptococcus pyogenes PBP2x with mutation conferring resistance to beta-lactam antibiotics ARO:3007530 PBP2x is a penicillin-binding protein and beta-lactam resistance enzyme. Mutations can cause resistance to some beta-lactam antibiotics. Spyo_PBP2x_BLA antibiotic_resistance ARO:3007531 Streptococcus pyogenes PBP2x conferring resistance to beta-lactam antibiotics ARO:3007531 PBP2x is a penicillin-binding protein and beta-lactam resistance enzyme. Mutations can cause resistance to some beta-lactam antibiotics. PMID:31630171 PMID:36374114 Spyo_PBP2x_BLA Proflavine, also called proflavin and diaminoacridine, is an acriflavine derivative, a disinfectant bacteriostatic against many gram-positive bacteria. CAS:92-62-6 ChEBI:8452 ChEMBL:CHEMBL55400 PubChem:7099 diaminoacridine proflavin antibiotic_resistance ARO:3007532 proflavine ARO:3007532 Proflavine, also called proflavin and diaminoacridine, is an acriflavine derivative, a disinfectant bacteriostatic against many gram-positive bacteria. PMID:36240541 An MCR-4-type colistin resistance gene variant. MCR-4.7 antibiotic_resistance ARO:3007533 MCR-4.7 ARO:3007533 An MCR-4-type colistin resistance gene variant. PMID:37171842 MCR-4.7 Arsinothricin is a natural product synthesized by the rhizosphere bacterium Burkholderia gladioli GSRB05 and is a broad-spectrum antibiotic effective against human pathogens such as carbapenem-resistant Enterobacter cloacae. It is a non-proteogenic amino acid and glutamate mimetic that inhibits bacterial glutamine synthetase. ChEBI:220158 PubChem:170988177 antibiotic_resistance ARO:3007534 arsinothricin ARO:3007534 Arsinothricin is a natural product synthesized by the rhizosphere bacterium Burkholderia gladioli GSRB05 and is a broad-spectrum antibiotic effective against human pathogens such as carbapenem-resistant Enterobacter cloacae. It is a non-proteogenic amino acid and glutamate mimetic that inhibits bacterial glutamine synthetase. PMID:36785875 Pretomanid is an antibiotic medication used for the treatment of multi-drug-resistant tuberculosis affecting the lungs. ChEMBL:CHEMBL227875 PubChem:456199 antibiotic_resistance ARO:3007535 pretomanid ARO:3007535 Pretomanid is an antibiotic medication used for the treatment of multi-drug-resistant tuberculosis affecting the lungs. PMID:36409105 Point mutation in M. tuberculosis rrnS conferring resistance to amikacin antibiotic. Mtub_16rrnS_AMK rrs antibiotic_resistance ARO:3007536 Mycobacterium tuberculosis 16S rRNA (rrnS) mutation conferring resistance to amikacin ARO:3007536 Point mutation in M. tuberculosis rrnS conferring resistance to amikacin antibiotic. PMID:35944069 PMID:37224060 Mtub_16rrnS_AMK Point mutation in M. tuberculosis rrnS conferring resistance to kanamycin antibiotic. Mtub_16rrnS_KAN rrs antibiotic_resistance ARO:3007537 Mycobacterium tuberculosis 16S rRNA (rrnS) mutation conferring resistance to kanamycin ARO:3007537 Point mutation in M. tuberculosis rrnS conferring resistance to kanamycin antibiotic. PMID:35944069 PMID:37224060 Mtub_16rrnS_KAN A cholic acid derivative of the traditional Chinese medicine (TCM) Tanreqing (TRQ), synergizes with amikacin against Staphylococcus aureus in vitro, and this synergistic killing was effective against diverse methicillin-resistant S. aureus (MRSA) variants. Mechanistically, chenodeoxycholic acid increases the uptake of aminoglycosides in a proton motive force-dependent manner by dissipating the chemical potential and potentiates reactive oxygen species (ROS) generation by inhibiting superoxide dismutase activity. CAS:474-25-9 ChEBI:16755 ChEMBL:CHEMBL240597 PubChem:10133 antibiotic_resistance ARO:3007538 chenodeoxycholic acid ARO:3007538 A cholic acid derivative of the traditional Chinese medicine (TCM) Tanreqing (TRQ), synergizes with amikacin against Staphylococcus aureus in vitro, and this synergistic killing was effective against diverse methicillin-resistant S. aureus (MRSA) variants. Mechanistically, chenodeoxycholic acid increases the uptake of aminoglycosides in a proton motive force-dependent manner by dissipating the chemical potential and potentiates reactive oxygen species (ROS) generation by inhibiting superoxide dismutase activity. PMID:36625660 APH(9)-Ic is a chromosomal-encoded aminoglycoside phosphotransferase in S. maltophilia. APH(9)-Ic antibiotic_resistance ARO:3007539 APH(9)-Ic ARO:3007539 APH(9)-Ic is a chromosomal-encoded aminoglycoside phosphotransferase in S. maltophilia. PMID:36699730 APH(9)-Ic Cyclomarins are cyclic heptapeptides containing four unusual amino acids. Cyclomarins target two different targets: Clp C1, a subunit of the caseinolytic protease of Mycobacterium tuberculosis (MTB), and PfAp3Ase of Plasmodium falciparum. Therefore, cyclomarins are interesting lead structures for the development of drugs against tuberculosis and malaria. antibiotic_resistance ARO:3007540 cyclomarin antibiotics ARO:3007540 Cyclomarins are cyclic heptapeptides containing four unusual amino acids. Cyclomarins target two different targets: Clp C1, a subunit of the caseinolytic protease of Mycobacterium tuberculosis (MTB), and PfAp3Ase of Plasmodium falciparum. Therefore, cyclomarins are interesting lead structures for the development of drugs against tuberculosis and malaria. PMID:27241518 PMID:36748577 Cyclomarin A was found to be bacteriocidal against bacteria replicating in culture broth and in human-derived macrophages and a series of multidrug resistant clinical isolates. It was identified as a potent antitubercular compound in a natural product whole cell screen. Importantly it kills both growing and dormant, non-replicating mycobacteria. ChEBI:182606 ChEMBL:CHEMBL1241238 PubChem:10772429 antibiotic_resistance ARO:3007541 cyclomarin A ARO:3007541 Cyclomarin A was found to be bacteriocidal against bacteria replicating in culture broth and in human-derived macrophages and a series of multidrug resistant clinical isolates. It was identified as a potent antitubercular compound in a natural product whole cell screen. Importantly it kills both growing and dormant, non-replicating mycobacteria. PMID:27241518 PMID:36748577 Cyclomarin B is a cyclomarin antibiotic. ChEBI:218852 PubChem:21593897 antibiotic_resistance ARO:3007542 cyclomarin B ARO:3007542 Cyclomarin B is a cyclomarin antibiotic. PMID:27241518 Cyclomarin C is a cyclomarin antibiotic. ChEBI:211272 PubChem:11205419 antibiotic_resistance ARO:3007543 cyclomarin C ARO:3007543 Cyclomarin C is a cyclomarin antibiotic. PMID:27241518 Sequence analysis of the gyrA gene showed that resistance of E. rhusiopathiae strains to enrofloxacin is due to a mutation at position 257. Erhu_gyrA_ENR antibiotic_resistance ARO:3007544 Erysipelothrix rhusiopathiae gyrA with mutation conferring resistance to enrofloxacin ARO:3007544 Sequence analysis of the gyrA gene showed that resistance of E. rhusiopathiae strains to enrofloxacin is due to a mutation at position 257. PMID:36986331 Erhu_gyrA_ENR Fungal beta-1,3-D-glucan synthase enzymes which include mutations to confer resistance to antifungal drug compounds. antibiotic_resistance ARO:3007545 antifungal-resistant beta-1,3-D-glucan synthase ARO:3007545 Fungal beta-1,3-D-glucan synthase enzymes which include mutations to confer resistance to antifungal drug compounds. PMID:19546367 Fungal beta-1,3-D-glucan synthases which include mutations to confer resistance to echinocandin-class antibiotics. antibiotic_resistance ARO:3007546 echinocandin antibiotic-resistant beta-1,3-D-glucan synthase ARO:3007546 Fungal beta-1,3-D-glucan synthases which include mutations to confer resistance to echinocandin-class antibiotics. PMID:19546367 Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug. CAS:53003-10-4 ChEBI:80025 ChEMBL:CHEMBL1208572 PubChem:3085092 antibiotic_resistance ARO:3007547 salinomycin ARO:3007547 Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug. PMID:37276926 Glucan synthase FKS2 is involved in the production of the fungal cell wall by the synthesis of the core component beta-1,3-glucan in Candida spp. Mutations in FKS2 have been shown to confer resistance to echinocandin antibiotic micafungin. antibiotic_resistance ARO:3007548 Candida spp. FKS2 with mutations conferring resistance to echinocandin antibiotics ARO:3007548 Glucan synthase FKS2 is involved in the production of the fungal cell wall by the synthesis of the core component beta-1,3-glucan in Candida spp. Mutations in FKS2 have been shown to confer resistance to echinocandin antibiotic micafungin. PMID:19546367 Fungal sterol regulatory element binding proteins are transcription factors that modulate antibiotic-susceptible genes. Mutations in these proteins confer resistance to antifungal drug compounds through differential gene regulation. antibiotic_resistance ARO:3007549 antibiotic resistant ergosterol biosynthesis pathway transcription factor ARO:3007549 Fungal sterol regulatory element binding proteins are transcription factors that modulate antibiotic-susceptible genes. Mutations in these proteins confer resistance to antifungal drug compounds through differential gene regulation. PMID:18487346 Upc2 is a sterol synthesis regulatory element binding protein in Candida spp. Mutations in Upc2 have been shown to confer resistance to azole antibiotics including fluconazole by upregulating ERG11 expression. antibiotic_resistance ARO:3007551 Candida spp. Upc2 with mutations conferring resistance to azole antibiotics ARO:3007551 Upc2 is a sterol synthesis regulatory element binding protein in Candida spp. Mutations in Upc2 have been shown to confer resistance to azole antibiotics including fluconazole by upregulating ERG11 expression. PMID:18487346 Pleiotropic Drug Resistance factors (PDR) are transcription factors in fungi that regulate the expression of genes encoding for efflux pumps causing multidrug resistance. antibiotic_resistance ARO:3007552 pleiotropic drug resistance transcription factors ARO:3007552 Pleiotropic Drug Resistance factors (PDR) are transcription factors in fungi that regulate the expression of genes encoding for efflux pumps causing multidrug resistance. PMID:15388433 PMID:7614555 PMID:9043118 CDR1 is a pleiotropic drug resistance gene encoding ABC transporters that contributes to multidrug antifungal resistance in Candida spp. antibiotic_resistance ARO:3007553 Candida spp. CDR1 ARO:3007553 CDR1 is a pleiotropic drug resistance gene encoding ABC transporters that contributes to multidrug antifungal resistance in Candida spp. PMID:7614555 CDR2 is a Pleiotropic drug resistance gene encoding ABC transporters that contributes to multidrug antifungal resistance in Candida spp. antibiotic_resistance ARO:3007554 Candida spp. CDR2 ARO:3007554 CDR2 is a Pleiotropic drug resistance gene encoding ABC transporters that contributes to multidrug antifungal resistance in Candida spp. PMID:9043118 Zn2Cys6 is a transcription factor family that includes mutations to confer resistance to azole-class antibiotics. antibiotic_resistance ARO:3007555 Zn2Cys6 transcription factors ARO:3007555 Zn2Cys6 is a transcription factor family that includes mutations to confer resistance to azole-class antibiotics. PMID:16452151 Fungal uracil phosphoribosyltransferases which include mutations to confer resistance to 5-flucytosine antibiotic. antibiotic_resistance ARO:3007556 fungal uracil phosphoribosyltransferase ARO:3007556 Fungal uracil phosphoribosyltransferases which include mutations to confer resistance to 5-flucytosine antibiotic. PMID:15504867 FUR1 is a fungal uracil phosphoribosyltransferase in Candida spp. It encodes the UPRT protein, also known as uracil pyrophosphorylase, which is a key regulating enzyme in pyrimidine salvage. Mutations in FUR1 have been shown to confer resistance to 5-flucytosine. antibiotic_resistance ARO:3007557 Candida spp. FUR1 with mutations conferring resistance to 5-flucytosine ARO:3007557 FUR1 is a fungal uracil phosphoribosyltransferase in Candida spp. It encodes the UPRT protein, also known as uracil pyrophosphorylase, which is a key regulating enzyme in pyrimidine salvage. Mutations in FUR1 have been shown to confer resistance to 5-flucytosine. PMID:15504867 5-Flucytosine is an antibiotic, particularly antifungal. It inhibits fungal RNA and DNA synthesis by changing the amino-acylation of tRNA, causing the amino acid pool to be altered and protein synthesis to be inhibited. PubChem:3366 antibiotic_resistance ARO:3007558 5-flucytosine ARO:3007558 5-Flucytosine is an antibiotic, particularly antifungal. It inhibits fungal RNA and DNA synthesis by changing the amino-acylation of tRNA, causing the amino acid pool to be altered and protein synthesis to be inhibited. PMID:37051439 FUR1 is a fungal uracil phosphoribosyltransferase in Saccharomyces spp. It encodes the UPRT protein, also known as uracil pyrophosphorylase, which is a key regulating enzyme in pyrimidine salvage. Mutations in FUR1 have been shown to confer resistance to 5-flucytosine. antibiotic_resistance ARO:3007559 Saccharomyces spp. FUR1 with mutations conferring resistance to 5-flucytosine ARO:3007559 FUR1 is a fungal uracil phosphoribosyltransferase in Saccharomyces spp. It encodes the UPRT protein, also known as uracil pyrophosphorylase, which is a key regulating enzyme in pyrimidine salvage. Mutations in FUR1 have been shown to confer resistance to 5-flucytosine. PMID:2189783 Any pyrimidine antifungal agent that has been used for the treatment of fungal infections in humans or animals. antibiotic_resistance ARO:3007560 pyrimidine antifungal drug ARO:3007560 The blaOXA-48-like enzyme demonstrated significant hydrolysis activity against meropenem, and the classical beta-lactamase inhibitor had no significant inhibitory effect. This is a novel OXA carbapenemases in S. xiamenensis. OXA-1038 antibiotic_resistance ARO:3007561 OXA-1038 ARO:3007561 The blaOXA-48-like enzyme demonstrated significant hydrolysis activity against meropenem, and the classical beta-lactamase inhibitor had no significant inhibitory effect. This is a novel OXA carbapenemases in S. xiamenensis. PMID:37317299 OXA-1038 The blaOXA-48-like enzyme demonstrated significant hydrolysis activity against meropenem, and the classical beta-lactamase inhibitor had no significant inhibitory effect. This is a novel OXA carbapenemases in S. xiamenensis. OXA-1039 antibiotic_resistance ARO:3007562 OXA-1039 ARO:3007562 The blaOXA-48-like enzyme demonstrated significant hydrolysis activity against meropenem, and the classical beta-lactamase inhibitor had no significant inhibitory effect. This is a novel OXA carbapenemases in S. xiamenensis. PMID:37317299 OXA-1039 TAC1 is a Zn2Cys6 transcription factor that transcriptionally activates efflux units CDR1 and CDR2. Mutations in TAC1 upregulate CDR1 and CDR2 causing increased resistance. antibiotic_resistance ARO:3007563 Candida spp. TAC1 with mutations conferring resistance to azole antibiotics ARO:3007563 TAC1 is a Zn2Cys6 transcription factor that transcriptionally activates efflux units CDR1 and CDR2. Mutations in TAC1 upregulate CDR1 and CDR2 causing increased resistance. PMID:16452151 The pH-dependant transcription factors regulate the expression of antifungal resistance-conferring genes based on the pH of the environment. antibiotic_resistance ARO:3007564 pH-responsive transcription factors ARO:3007564 The pH-dependant transcription factors regulate the expression of antifungal resistance-conferring genes based on the pH of the environment. PMID:29610197 Aspergillus spp. cyp51A is a fungal cytochrome P450 enzyme with mutations in the gene causing triazole resistance. antibiotic_resistance ARO:3007565 Aspergillus spp. cyp51A with mutations conferring resistance to triazoles antibiotics ARO:3007565 Aspergillus spp. cyp51A is a fungal cytochrome P450 enzyme with mutations in the gene causing triazole resistance. PMID:12604551 PMID:15215142 Cryptococcus spp. AFR1 gene is an ABC transporter gene that contributes to antifungal resistance through antibiotic efflux. antibiotic_resistance ARO:3007566 Cryptococcus spp. AFR1 ARO:3007566 Cryptococcus spp. AFR1 gene is an ABC transporter gene that contributes to antifungal resistance through antibiotic efflux. PMID:12519188 UDP-glucuronic acid decarboxylase catalyzes the decarboxylation of UDP-glucuronic acid. Accumulation of UDP-glucuronic acid mediates resistance to 5-flucytosine. antibiotic_resistance ARO:3007567 UDP-glucuronic acid decarboxylase ARO:3007567 UDP-glucuronic acid decarboxylase catalyzes the decarboxylation of UDP-glucuronic acid. Accumulation of UDP-glucuronic acid mediates resistance to 5-flucytosine. PMID:31913284 PMID:34103502 UXS1 is a UDP-glucuronic acid decarboxylase. Deletion of UXS1 confers resistance to 5-flucytosine by accumulation of UDP-glucoronic acid, thereby suppressing the cellular toxicity of 5-flucytosine. antibiotic_resistance ARO:3007568 Cryptococcus spp. UXS1 conferring resistance to 5-flucytosine via absence ARO:3007568 UXS1 is a UDP-glucuronic acid decarboxylase. Deletion of UXS1 confers resistance to 5-flucytosine by accumulation of UDP-glucoronic acid, thereby suppressing the cellular toxicity of 5-flucytosine. PMID:31913284 PMID:34103502 Specific automated system of analysis for determining antimicrobial susceptibility developed by Giles Scientific. antibiotic_resistance ARO:3007569 BIOMIC Microbiology System ARO:3007569 Mycaminosyltylonolide is a tylosin derivative with promising anti- P. aeruginosa activity, especially when combined with other antibiotics such as polymixin B. PubChem:6437420 5-O-mycaminosyltylonolide antibiotic_resistance ARO:3007570 Mycaminosyltylonolide ARO:3007570 Mycaminosyltylonolide is a tylosin derivative with promising anti- P. aeruginosa activity, especially when combined with other antibiotics such as polymixin B. PMID:37208456 Cefquinome is a fourth-generation cephalosporin with pharmacological and antibacterial properties valuable in the treatment of coliform mastitis and other infections. ChEMBL:CHEMBL1631107 PubChem:5464355 antibiotic_resistance ARO:3007571 cefquinome ARO:3007571 Cefquinome is a fourth-generation cephalosporin with pharmacological and antibacterial properties valuable in the treatment of coliform mastitis and other infections. PMID:37280708 Cinnamaldehyde was found to enhance the antibacterial activity of ceftriaxone sodium against MDR Salmonella in vitro by significantly reducing the expression of extended-spectrum beta-lactamase, inhibiting the development of drug resistance under ceftriaxone selective pressure in vitro, damaging the cell membrane, and affecting its basic metabolism. CAS:14371-10-9 ChEBI:16731 ChEMBL:CHEMBL293492 PubChem:637511 antibiotic_resistance ARO:3007572 cinnamaldehyde ARO:3007572 Cinnamaldehyde was found to enhance the antibacterial activity of ceftriaxone sodium against MDR Salmonella in vitro by significantly reducing the expression of extended-spectrum beta-lactamase, inhibiting the development of drug resistance under ceftriaxone selective pressure in vitro, damaging the cell membrane, and affecting its basic metabolism. PMID:37298240 Fasamycins and congeners are a class of rare aromatic polyketides possessing a partially reduced 1-phenyltetracene pentacyclic core. antibiotic_resistance ARO:3007573 fasamycin ARO:3007573 Fasamycins and congeners are a class of rare aromatic polyketides possessing a partially reduced 1-phenyltetracene pentacyclic core. PMID:37327570 The formicamycins are promising antibiotics first identified in Streptomyces formicae KY5, which produces the compounds at low levels. antibiotic_resistance ARO:3007574 formicamycin ARO:3007574 The formicamycins are promising antibiotics first identified in Streptomyces formicae KY5, which produces the compounds at low levels. PMID:33440167 Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. PubChem:57404528 antibiotic_resistance ARO:3007575 fasamycin A ARO:3007575 Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. PMID:37327570 Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. PubChem:57404257 antibiotic_resistance ARO:3007576 fasamycin B ARO:3007576 Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. PMID:37327570 Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. ChEBI:226604 PubChem:156016388 antibiotic_resistance ARO:3007577 fasamycin G ARO:3007577 Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. PMID:37327570 Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. ChEBI:226609 PubChem:156017923 antibiotic_resistance ARO:3007578 fasamycin H ARO:3007578 Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. PMID:37327570 Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. ChEBI:226614 PubChem:156012442 antibiotic_resistance ARO:3007579 fasamycin I ARO:3007579 Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. PMID:37327570 Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. ChEBI:226620 PubChem:156017733 antibiotic_resistance ARO:3007580 fasamycin J ARO:3007580 Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. PMID:37327570 Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. ChEBI:226626 PubChem:156581097 antibiotic_resistance ARO:3007581 fasamycin K ARO:3007581 Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. PMID:37327570 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. ChEBI:219437 ChEMBL:CHEMBL4647089 PubChem:146684581 antibiotic_resistance ARO:3007582 formicamycin A ARO:3007582 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. ChEBI:219443 ChEMBL:CHEMBL4642114 PubChem:146684582 antibiotic_resistance ARO:3007583 formicamycin B ARO:3007583 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. ChEBI:219450 ChEMBL:CHEMBL4646535 PubChem:146684583 antibiotic_resistance ARO:3007584 formicamycin C ARO:3007584 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. ChEBI:219460 ChEMBL:CHEMBL4647076 PubChem:146684585 antibiotic_resistance ARO:3007585 formicamycin E ARO:3007585 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. ChEBI:219506 PubChem:146684593 antibiotic_resistance ARO:3007586 formicamycin M ARO:3007586 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. ChEBI:226636 ChEMBL:CHEMBL4648236 PubChem:156020171 antibiotic_resistance ARO:3007587 formicamycin O ARO:3007587 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. ChEBI:219500 PubChem:146684592 antibiotic_resistance ARO:3007588 formicamycin L ARO:3007588 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. ChEBI:219466 ChEMBL:CHEMBL4641739 PubChem:146684586 antibiotic_resistance ARO:3007589 formicamycin F ARO:3007589 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. ChEBI:226642 ChEMBL:CHEMBL4637392 PubChem:156011794 antibiotic_resistance ARO:3007590 formicamycin P ARO:3007590 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. ChEBI:219470 ChEMBL:CHEMBL4645206 PubChem:146684587 antibiotic_resistance ARO:3007591 formicamycin G ARO:3007591 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. ChEBI:219455 PubChem:146684584 antibiotic_resistance ARO:3007592 formicamycin D ARO:3007592 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. ChEBI:226631 ChEMBL:CHEMBL4633735 PubChem:156010277 antibiotic_resistance ARO:3007593 formicamycin N ARO:3007593 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. ChEBI:219476 PubChem:146684588 antibiotic_resistance ARO:3007594 formicamycin H ARO:3007594 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. ChEBI:226647 ChEMBL:CHEMBL4643580 PubChem:156018422 antibiotic_resistance ARO:3007595 formicamycin Q ARO:3007595 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. ChEBI:219484 PubChem:146684589 antibiotic_resistance ARO:3007596 formicamycin I ARO:3007596 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. ChEBI:219490 PubChem:146684590 antibiotic_resistance ARO:3007597 formicamycin J ARO:3007597 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. ChEBI:219496 PubChem:146684591 antibiotic_resistance ARO:3007598 formicamycin K ARO:3007598 Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. PMID:33440167 Propolis has a significant synergistic effect in combination with ciprofloxacin, erythromycin, and gentamycin. It has a potent inhibitory activity toward the S. aureus (MRS USA300) pump system. ChEBI:66778 PubChem:11148893 antibiotic_resistance ARO:3007599 propolis ARO:3007599 Propolis has a significant synergistic effect in combination with ciprofloxacin, erythromycin, and gentamycin. It has a potent inhibitory activity toward the S. aureus (MRS USA300) pump system. PMID:36777436 The polyketide antibiotics cervimycins are natural products of Streptomyces tendae HKI 0179 with promising activity against multidrug-resistant staphylococci and vancomycin-resistant enterococci. antibiotic_resistance ARO:3007600 cervimycin ARO:3007600 The polyketide antibiotics cervimycins are natural products of Streptomyces tendae HKI 0179 with promising activity against multidrug-resistant staphylococci and vancomycin-resistant enterococci. PMID:36173303 Cervimycins are polyketide antibiotics. ChEBI:209712 PubChem:11557219 antibiotic_resistance ARO:3007601 cervimycin A ARO:3007601 Cervimycins are polyketide antibiotics. PMID:36173303 Cervimycins are polyketide antibiotics. ChEBI:206185 PubChem:11693822 antibiotic_resistance ARO:3007602 cervimycin B ARO:3007602 Cervimycins are polyketide antibiotics. PMID:36173303 Cervimycins are polyketide antibiotics. ChEBI:208953 PubChem:54687465 antibiotic_resistance ARO:3007603 cervimycin C ARO:3007603 Cervimycins are polyketide antibiotics. PMID:36173303 Cervimycins are polyketide antibiotics. ChEBI:198705 PubChem:54677926 antibiotic_resistance ARO:3007604 cervimycin D ARO:3007604 Cervimycins are polyketide antibiotics. PMID:36173303 Cervimycins are polyketide antibiotics. PubChem:54726226 antibiotic_resistance ARO:3007605 cervimycin K1 ARO:3007605 Cervimycins are polyketide antibiotics. PMID:36173303 Cervimycins are polyketide antibiotics. PubChem:54579611 antibiotic_resistance ARO:3007606 cervimycin K2 ARO:3007606 Cervimycins are polyketide antibiotics. PMID:36173303 Cervimycins are polyketide antibiotics. PubChem:54726225 antibiotic_resistance ARO:3007607 cervimycin N ARO:3007607 Cervimycins are polyketide antibiotics. PMID:36173303 ERG11 is a cytochrome P450 enzyme in Candida species that is not functional when bound by azole antibiotics including fluconazole and itraconazole. However, high levels of ERG11 expression can overcome effective azole doses. antibiotic_resistance ARO:3007608 antibiotic susceptible ERG11 ARO:3007608 ERG11 is a cytochrome P450 enzyme in Candida species that is not functional when bound by azole antibiotics including fluconazole and itraconazole. However, high levels of ERG11 expression can overcome effective azole doses. PMID:18487346 PMID:35163552 Increased expression of an antibiotic target protein can overcome effective dose of an antibiotic, leading to reduced susceptibility. antibiotic_resistance ARO:3007609 antibiotic target overexpression ARO:3007609 Genes that directly or indirectly modulate azole resistance. antibiotic_resistance ARO:3007610 gene modulating azole resistance ARO:3007610 Sarafloxacin is used for treatment and control of bacterial infections in poultry caused by Escherichia coli and Salmonella spp. It was removed from the market by manufacturers in 2001. ChEMBL:CHEMBL37858 PubChem:56208 antibiotic_resistance ARO:3007611 sarafloxacin ARO:3007611 Sarafloxacin is used for treatment and control of bacterial infections in poultry caused by Escherichia coli and Salmonella spp. It was removed from the market by manufacturers in 2001. PMID:37250042 Hinokitiol (beta-thujaplicin), a natural tropolone derivative found in the heartwood of cupressaceous plants, has been widely used in oral and skin care products as an antimicrobial agent, specifically to enhance tetracyclines against Staphylococcus aureus. CAS:499-44-5 ChEBI:10447 ChEMBL:CHEMBL48310 PubChem:3611 antibiotic_resistance ARO:3007612 hinokitiol ARO:3007612 Hinokitiol (beta-thujaplicin), a natural tropolone derivative found in the heartwood of cupressaceous plants, has been widely used in oral and skin care products as an antimicrobial agent, specifically to enhance tetracyclines against Staphylococcus aureus. PMID:36943047 The phenolic diterpene totarol had good antimicrobial activity against effluxing strains of Staphylococcus aureus. Totoral acts as a NorA efflux pump inhibitor as well as an antistaphylococcal antimicrobial agent. CAS:511-15-9 ChEBI:69241 ChEMBL:CHEMBL487602 PubChem:92783 antibiotic_resistance ARO:3007613 totarol ARO:3007613 The phenolic diterpene totarol had good antimicrobial activity against effluxing strains of Staphylococcus aureus. Totoral acts as a NorA efflux pump inhibitor as well as an antistaphylococcal antimicrobial agent. PMID:17664318 Resveratrol is a naturally occurring polyphenolic compound that is produced by many different plants, displays antioxidant properties, and protects macromolecules against damage by reactive oxygen species. ATP synthase inhibition with resveratrol can enhance the activity of aminoglycosides against S. aureus and potentially against other bacterial pathogens. CAS:501-36-0 ChEBI:27881 ChEMBL:CHEMBL165 PubChem:445154 antibiotic_resistance ARO:3007614 resveratrol ARO:3007614 Resveratrol is a naturally occurring polyphenolic compound that is produced by many different plants, displays antioxidant properties, and protects macromolecules against damage by reactive oxygen species. ATP synthase inhibition with resveratrol can enhance the activity of aminoglycosides against S. aureus and potentially against other bacterial pathogens. PMID:29906565 Pyrrolomycins are protonophore antibiotics produced by Actinosporangium and Streptomyces. The mechanism of their antimicrobial activity consists in depolarization of bacterial membrane, leading to the suppression of bacterial bioenergetics through the uncoupling of oxidative phosphorylation. antibiotic_resistance ARO:3007615 pyrrolomycin antibiotic ARO:3007615 Pyrrolomycins are protonophore antibiotics produced by Actinosporangium and Streptomyces. The mechanism of their antimicrobial activity consists in depolarization of bacterial membrane, leading to the suppression of bacterial bioenergetics through the uncoupling of oxidative phosphorylation. PMID:36171648 Pyrrolomycins are protonophores with antibiotic activity. ChEBI:156550 PubChem:133275 antibiotic_resistance ARO:3007616 pyrrolomycin A ARO:3007616 Pyrrolomycins are protonophores with antibiotic activity. PMID:36171648 Pyrrolomycins are protonophores with antibiotic activity. ChEBI:220052 PubChem:133274 antibiotic_resistance ARO:3007617 pyrrolomycin B ARO:3007617 Pyrrolomycins are protonophores with antibiotic activity. PMID:36171648 Pyrrolomycins are protonophores with antibiotic activity. ChEBI:210117 PubChem:133779 antibiotic_resistance ARO:3007618 pyrrolomycin C ARO:3007618 Pyrrolomycins are protonophores with antibiotic activity. PMID:36171648 Pyrrolomycins are protonophores with antibiotic activity. ChEBI:220079 ChEMBL:CHEMBL4101922 PubChem:133780 antibiotic_resistance ARO:3007619 pyrrolomycin D ARO:3007619 Pyrrolomycins are protonophores with antibiotic activity. PMID:36171648 Pyrrolomycins are protonophores with antibiotic activity. PubChem:5487782 antibiotic_resistance ARO:3007620 pyrrolomycin E ARO:3007620 Pyrrolomycins are protonophores with antibiotic activity. PMID:36171648 Pyrrolomycins are protonophores with antibiotic activity. PubChem:3086276 antibiotic_resistance ARO:3007621 pyrrolomycin F ARO:3007621 Pyrrolomycins are protonophores with antibiotic activity. PMID:36171648 Pyrrolomycins are protonophores with antibiotic activity. ChEBI:222909 ChEMBL:CHEMBL4069856 PubChem:181928 antibiotic_resistance ARO:3007622 pyrrolomycin F2a ARO:3007622 Pyrrolomycins are protonophores with antibiotic activity. PMID:36171648 Pyrrolomycins are protonophores with antibiotic activity. ChEBI:222903 ChEMBL:CHEMBL4087261 PubChem:102115511 antibiotic_resistance ARO:3007623 pyrrolomycin F2b ARO:3007623 Pyrrolomycins are protonophores with antibiotic activity. PMID:36171648 Pyrrolomycins are protonophores with antibiotic activity. ChEMBL:CHEMBL464559 PubChem:11360758 antibiotic_resistance ARO:3007624 pyrrolomycin G ARO:3007624 Pyrrolomycins are protonophores with antibiotic activity. PMID:36171648 Pyrrolomycins are protonophores with antibiotic activity. ChEMBL:CHEMBL513636 PubChem:11303705 antibiotic_resistance ARO:3007625 pyrrolomycin H ARO:3007625 Pyrrolomycins are protonophores with antibiotic activity. PMID:36171648 Pyrrolomycins are protonophores with antibiotic activity. ChEBI:222896 ChEMBL:CHEMBL4095323 PubChem:102115512 antibiotic_resistance ARO:3007626 pyrrolomycin F3 ARO:3007626 Pyrrolomycins are protonophores with antibiotic activity. PMID:36171648 Pyrrolomycins are protonophores with antibiotic activity. ChEBI:217964 PubChem:11772125 antibiotic_resistance ARO:3007627 pyrrolomycin I ARO:3007627 Pyrrolomycins are protonophores with antibiotic activity. PMID:36171648 Pyrrolomycins are protonophores with antibiotic activity. ChEBI:206255 ChEMBL:CHEMBL451925 PubChem:11337778 antibiotic_resistance ARO:3007628 pyrrolomycin J ARO:3007628 Pyrrolomycins are protonophores with antibiotic activity. PMID:36171648 The cadasides are calcium-dependent cyclic acidic lipopeptide antibiotics that disrupt cell wall biosynthesis and show activity against multiple drug-resistant Gram-positive pathogens. antibiotic_resistance ARO:3007629 cadaside antibiotic ARO:3007629 The cadasides are calcium-dependent cyclic acidic lipopeptide antibiotics that disrupt cell wall biosynthesis and show activity against multiple drug-resistant Gram-positive pathogens. PMID:36168660 Cadasides are lipopeptides with antibiotic activity. ChEBI:226051 PubChem:146682091 antibiotic_resistance ARO:3007630 cadaside A ARO:3007630 Cadasides are lipopeptides with antibiotic activity. PMID:36168660 Cadasides are lipopeptides with antibiotic activity. ChEBI:226057 PubChem:146682092 antibiotic_resistance ARO:3007631 cadaside B ARO:3007631 Cadasides are lipopeptides with antibiotic activity. PMID:36168660 FRI-11 is a FRI-type carbapenem-hydrolyzing class A beta-lactamase. FRI-11 antibiotic_resistance ARO:3007632 FRI-11 ARO:3007632 FRI-11 is a FRI-type carbapenem-hydrolyzing class A beta-lactamase. PMID:36773190 FRI-11 KPC-125 is a KPC-type class A beta-lactamase. KPC-125 is a variant of KPC-3, differing by a D179A polymorphism within the omega-loop region. KPC-125 antibiotic_resistance ARO:3007633 KPC-125 ARO:3007633 KPC-125 is a KPC-type class A beta-lactamase. KPC-125 is a variant of KPC-3, differing by a D179A polymorphism within the omega-loop region. PMID:36112395 KPC-125 CAE beta-lactamases are a novel class A serine beta-lactamase family first isolated from Comamonas aquatica. antibiotic_resistance ARO:3007634 CAE beta-lactamase ARO:3007634 CAE beta-lactamases are a novel class A serine beta-lactamase family first isolated from Comamonas aquatica. PMID:36869066 CAE-1 is a CAE beta-lactamase and confers resistance to ampicillin, piperacillin, cefazolin, cefuroxime, and ceftriaxone, and elevates the MIC of ampicillin-sulbactam two-fold in Escherichia coli DH5alpha, suggesting that CAE-1 functions as a broad-spectrum beta-lactamase. CAE-1 antibiotic_resistance ARO:3007635 CAE-1 ARO:3007635 CAE-1 is a CAE beta-lactamase and confers resistance to ampicillin, piperacillin, cefazolin, cefuroxime, and ceftriaxone, and elevates the MIC of ampicillin-sulbactam two-fold in Escherichia coli DH5alpha, suggesting that CAE-1 functions as a broad-spectrum beta-lactamase. PMID:36869066 CAE-1 Iboxamycin is a fully synthetic lincosamide antibiotic. Like other lincosamides, it selectively targets the bacterial ribosome and prevents elongation of the peptide chain. Iboxamycin has been shown to be effective against bacterial strains otherwise resistant to licosamide antibiotics. PubChem:156613433 antibiotic_resistance ARO:3007636 iboxamycin ARO:3007636 Iboxamycin is a fully synthetic lincosamide antibiotic. Like other lincosamides, it selectively targets the bacterial ribosome and prevents elongation of the peptide chain. Iboxamycin has been shown to be effective against bacterial strains otherwise resistant to licosamide antibiotics. PMID:34707295 CplR is an ABC-F ATPase ribosomal protection protein from Clostridioides difficile which confers resistance to pleuromutilins and lincosamides. Its resistance to these antibiotics increases in synergy with erythromcyin resistance methylases (e.g., ermB). cplR antibiotic_resistance ARO:3007637 Clostridioides difficile cplR ARO:3007637 CplR is an ABC-F ATPase ribosomal protection protein from Clostridioides difficile which confers resistance to pleuromutilins and lincosamides. Its resistance to these antibiotics increases in synergy with erythromcyin resistance methylases (e.g., ermB). PMID:36951104 cplR Hygromycin A is an antibiotic produced by Streptomyces hygroscopicus. It inhibits translation by binding to the peptidyl transferase center on the large ribosomal subunit. This prevents the binding of aminoacyl-tRNA to the A-site. Not to confused with Hygromycin B, which is structurally distinct. CAS:6379-56-2 ChEBI:69414 ChEMBL:CHEMBL7611 PubChem:6433481 totomycin antibiotic_resistance ARO:3007638 hygromycin A ARO:3007638 Hygromycin A is an antibiotic produced by Streptomyces hygroscopicus. It inhibits translation by binding to the peptidyl transferase center on the large ribosomal subunit. This prevents the binding of aminoacyl-tRNA to the A-site. Not to confused with Hygromycin B, which is structurally distinct. PMID:26028538 A201A is a nucleoside antibiotic. It inhibits translation by binding to the peptidyl transferase center on the large ribosomal subunit. This prevents the binding of aminoacyl-tRNA to the A-site. ChEBI:222171 ChEMBL:CHEMBL100042 PubChem:6441582 antibiotic_resistance ARO:3007639 A201A ARO:3007639 A201A is a nucleoside antibiotic. It inhibits translation by binding to the peptidyl transferase center on the large ribosomal subunit. This prevents the binding of aminoacyl-tRNA to the A-site. PMID:26028538 PDR1 is a transcription factor that regulates the expression of several genes encoding ABC transporters, contributing to multidrug resistance. antibiotic_resistance ARO:3007640 Candida spp. pleiotropic drug resistance factor 1 ARO:3007640 PDR1 is a transcription factor that regulates the expression of several genes encoding ABC transporters, contributing to multidrug resistance. PMID:15388433 Fungal nucleobase transporters facilitate the movement of nucleobases across the fungal cell membrane. The absence confers resistance to antibiotics by preventing antibiotic entry into the cell. antibiotic_resistance ARO:3007641 fungal nucleobase transporters ARO:3007641 Fungal nucleobase transporters facilitate the movement of nucleobases across the fungal cell membrane. The absence confers resistance to antibiotics by preventing antibiotic entry into the cell. PMID:17784857 FcyB encodes for purine-cytosine permease in fungal cells. Downregulation or absence of fcyB confers resistance to antibiotics by preventing entry into the cell. antibiotic_resistance ARO:3007642 Aspergillus spp. fcyB conferring resistance to 5-flucytosine via reduced permeability ARO:3007642 FcyB encodes for purine-cytosine permease in fungal cells. Downregulation or absence of fcyB confers resistance to antibiotics by preventing entry into the cell. PMID:29610197 PacC is a pH-responsive transcription factor. It regulates the expression of antibiotic susceptible genes whose absence confers resistance to antibiotics. antibiotic_resistance ARO:3007643 Aspergillus spp. transcription factor pacC ARO:3007643 PacC is a pH-responsive transcription factor. It regulates the expression of antibiotic susceptible genes whose absence confers resistance to antibiotics. PMID:29610197 CplR is an ABC-F ATPase ribosomal protection protein from Clostridium perfringes which confers resistance to pleuromutilins and lincosamides. Cper_cplR antibiotic_resistance ARO:3007644 Clostridium perfringes cplR ARO:3007644 CplR is an ABC-F ATPase ribosomal protection protein from Clostridium perfringes which confers resistance to pleuromutilins and lincosamides. PMID:36951104 Cper_cplR CplR is an ABC-F ATPase ribosomal protection protein from Clostridium sporogenes which confers resistance to pleuromutilins and lincosamides. Cspo_cplR antibiotic_resistance ARO:3007645 Clostridium sporogenes cplR ARO:3007645 CplR is an ABC-F ATPase ribosomal protection protein from Clostridium sporogenes which confers resistance to pleuromutilins and lincosamides. PMID:36951104 Cspo_cplR vmlR2 is an ABC-F ATPase ribosomal protection protein from Neobacillus vireti (formerly known as Bacillus vireti). This representative of the ARE2 subfamily has an unusually long linker domain. Confers resistance to some lincosamide and nucleoside antibiotics. antibiotic_resistance ARO:3007646 Neobacillus vireti vmlR2 ARO:3007646 vmlR2 is an ABC-F ATPase ribosomal protection protein from Neobacillus vireti (formerly known as Bacillus vireti). This representative of the ARE2 subfamily has an unusually long linker domain. Confers resistance to some lincosamide and nucleoside antibiotics. PMID:36951104 PSZ beta-lactamases are a novel AmpC enzyme gene family, which was found on a strain of Pantoea endophytica isolated from a rabbit in a livestock farm in China. It shows resistance to penicillins and several cephalosporins, and shares the highest amino acid similarity with the function-characterized AmpC enzyme ERH-1. antibiotic_resistance ARO:3007647 PSZ beta-lactamase ARO:3007647 PSZ beta-lactamases are a novel AmpC enzyme gene family, which was found on a strain of Pantoea endophytica isolated from a rabbit in a livestock farm in China. It shows resistance to penicillins and several cephalosporins, and shares the highest amino acid similarity with the function-characterized AmpC enzyme ERH-1. PMID:37529328 PSZ-1 is a PSZ beta-lactamase found in Pantoea endophytica. The gene showed resistance to penicillins and several first-, second-and third-generation cephalosporins as well as aztreonam. PSZ-1 antibiotic_resistance ARO:3007648 PSZ-1 ARO:3007648 PSZ-1 is a PSZ beta-lactamase found in Pantoea endophytica. The gene showed resistance to penicillins and several first-, second-and third-generation cephalosporins as well as aztreonam. PMID:37529328 PSZ-1 A CDA beta-lactamase was identified as a novel class C enzyme that was phylogenetically and biochemically close to the chromosome-borne beta-lactamases of the genera Enterobacter and Citrobacter. antibiotic_resistance ARO:3007649 CDA beta-lactamase ARO:3007649 A CDA beta-lactamase was identified as a novel class C enzyme that was phylogenetically and biochemically close to the chromosome-borne beta-lactamases of the genera Enterobacter and Citrobacter. PMID:25136020 CDA-1 was recovered from a urine sample and is intermediate or resistant to third-generation cephalosporins and carbapenems. Susceptibility testing, isoelectric focusing, and analysis of outer membrane proteins showed that AmpC beta-lactamase expression combined with porin deficiency accounted for the carbapenem resistance. CDA-1 antibiotic_resistance ARO:3007650 CDA-1 ARO:3007650 CDA-1 was recovered from a urine sample and is intermediate or resistant to third-generation cephalosporins and carbapenems. Susceptibility testing, isoelectric focusing, and analysis of outer membrane proteins showed that AmpC beta-lactamase expression combined with porin deficiency accounted for the carbapenem resistance. PMID:25136020 CDA-1 Carmoisine is widely used as a food coloring agent. Carmoisine-mediated reduction of biofilm in Pseudomonas aeruginosa is due to its interaction with LasR and interference with the QS system. ChEBI:82414 PubChem:19118 antibiotic_resistance ARO:3007651 carmoisine ARO:3007651 Carmoisine is widely used as a food coloring agent. Carmoisine-mediated reduction of biofilm in Pseudomonas aeruginosa is due to its interaction with LasR and interference with the QS system. PMID:37485898 Lipoxin A4 is a Specialized Pro-resolving Mediator and has direct effects on P. aeruginosa where it reduced biofilm formation and promoted ciprofloxacin antibiotic efficacy in a static biofilm-forming system. Further studies show lipoxin A4 can help antibiotic efficacy and promote monocyte activity against established P. aeruginosa biofilm formed under hydrodynamic conditions. ChEBI:6498 ChEMBL:CHEMBL4576804 PubChem:5280914 LxA4 antibiotic_resistance ARO:3007652 lipoxin A4 ARO:3007652 Lipoxin A4 is a Specialized Pro-resolving Mediator and has direct effects on P. aeruginosa where it reduced biofilm formation and promoted ciprofloxacin antibiotic efficacy in a static biofilm-forming system. Further studies show lipoxin A4 can help antibiotic efficacy and promote monocyte activity against established P. aeruginosa biofilm formed under hydrodynamic conditions. PMID:37462621 The production of pyocyanin by Pseudomonas aeruginosa increases its virulence, fitness and biofilm formation. Ascorbic acid combined with furanone-30 elevated quorum-sensing inhibition in P. aeruginosa, which was directly associated with significantly reduced virulence, adhesion, aggregation and biofilm formation and enhanced antibiotic-mediated bacterial killing. CAS:50-81-7 ChEBI:29073 ChEMBL:CHEMBL196 PubChem:54670067 antibiotic_resistance ARO:3007653 ascorbic acid ARO:3007653 The production of pyocyanin by Pseudomonas aeruginosa increases its virulence, fitness and biofilm formation. Ascorbic acid combined with furanone-30 elevated quorum-sensing inhibition in P. aeruginosa, which was directly associated with significantly reduced virulence, adhesion, aggregation and biofilm formation and enhanced antibiotic-mediated bacterial killing. PMID:37520362 Erm(56) is an Erm ribosomal RNA methyltransferase. Expression of the cloned erm(56) confers resistance to MLSB in T. pyogenes and Escherichia coli. erm(56) antibiotic_resistance ARO:3007654 erm(56) ARO:3007654 Erm(56) is an Erm ribosomal RNA methyltransferase. Expression of the cloned erm(56) confers resistance to MLSB in T. pyogenes and Escherichia coli. PMID:37417762 erm(56) Nifuroxazide is an oral nitrofuran antibiotic used to treat colitis and diarrhea in humans and non-humans. It has recently been explored to be repurposed for parasitic diseases. ChEBI:135136 ChEMBL:CHEMBL244888 PubChem:5337997 antibiotic_resistance ARO:3007655 nifuroxazide ARO:3007655 Nifuroxazide is an oral nitrofuran antibiotic used to treat colitis and diarrhea in humans and non-humans. It has recently been explored to be repurposed for parasitic diseases. PMID:37409934 Inactivation of the F420-dependent anti-oxidant mechanism that protects M.tuberculosis against oxidative stress and bactericidal agents plays a role in antibiotic resistance. antibiotic_resistance ARO:3007656 antibiotic resistant Mycobacterium tuberculosis nitroreductase ARO:3007656 Inactivation of the F420-dependent anti-oxidant mechanism that protects M.tuberculosis against oxidative stress and bactericidal agents plays a role in antibiotic resistance. PMID:36409105 Efflux pumps also regulate the level of metal ions in the cytoplasm but are toxic when in excess. Metals often act as a facilitator in the proliferation and persistence of antibiotic resistance. Therefore, metal contamination in natural environments could have an important role in maintaining and promoting antibiotic resistance. The presence of metals co-selects for antibiotic resistance and leads to the development of cross-resistance. Micro-organisms adopt various mechanisms that may confer resistance against more than one antimicrobial, of which multidrug efflux systems are the most common. antibiotic_resistance ARO:3007657 metal transporters with antibiotic efflux ARO:3007657 Efflux pumps also regulate the level of metal ions in the cytoplasm but are toxic when in excess. Metals often act as a facilitator in the proliferation and persistence of antibiotic resistance. Therefore, metal contamination in natural environments could have an important role in maintaining and promoting antibiotic resistance. The presence of metals co-selects for antibiotic resistance and leads to the development of cross-resistance. Micro-organisms adopt various mechanisms that may confer resistance against more than one antimicrobial, of which multidrug efflux systems are the most common. PMID:36282241 Albicidin phytotoxins produced by the sugarcane pathogen Xanthomonas albilineans is a potent DNA gyrase inhibitor with inhibitory effects significantly better than most DNA gyrase inhibitors. Albicidin acts primarily by inhibiting the religation of the cleaved DNA intermediate during the gyrase catalytic sequence similar to quinolones. ChEBI:218232 ChEMBL:CHEMBL5281137 PubChem:78322514 antibiotic_resistance ARO:3007658 albicidin ARO:3007658 Albicidin phytotoxins produced by the sugarcane pathogen Xanthomonas albilineans is a potent DNA gyrase inhibitor with inhibitory effects significantly better than most DNA gyrase inhibitors. Albicidin acts primarily by inhibiting the religation of the cleaved DNA intermediate during the gyrase catalytic sequence similar to quinolones. PMID:17074789 PMID:31451755 Ectopic expression of NiCoT in Escherichia coli CS109 resulted in the increase of intracellular nickel uptake with enhanced tolerance towards several antibiotics when NiCoT was overexpressed in E. coli and Mycobacterium smegmatis. The presence of a sub-inhibitory dose of nickel resulted in the manifestation of low-level tolerance towards these drugs. NiCoT NicT Rv2856 antibiotic_resistance ARO:3007659 putative nickel/cobalt transporter ARO:3007659 Ectopic expression of NiCoT in Escherichia coli CS109 resulted in the increase of intracellular nickel uptake with enhanced tolerance towards several antibiotics when NiCoT was overexpressed in E. coli and Mycobacterium smegmatis. The presence of a sub-inhibitory dose of nickel resulted in the manifestation of low-level tolerance towards these drugs. PMID:36282241 Rv2856 Clerocidin is a terpenoid antibiotic that inhibits bacterial DNA gyrase. It is a natural diterpenoid which has been shown to selectively react with single-stranded bases without targeting the double helix. ChEBI:199447 PubChem:9896400 antibiotic_resistance ARO:3007660 clerocidin ARO:3007660 Clerocidin is a terpenoid antibiotic that inhibits bacterial DNA gyrase. It is a natural diterpenoid which has been shown to selectively react with single-stranded bases without targeting the double helix. PMID:12930966 ddn is a protein-coding gene involved in the bioreductive activation of bicyclic 4-nitroimidazole prodrugs such as PA-824 and delamanid developed for anti-tuberculosis therapy against both replicating and persistent bacteria. Mtub_ddn_MULT antibiotic_resistance ARO:3007661 Mycobacterium tuberculosis ddn mutation conferring resistance to nitroimidazole antibiotics ARO:3007661 ddn is a protein-coding gene involved in the bioreductive activation of bicyclic 4-nitroimidazole prodrugs such as PA-824 and delamanid developed for anti-tuberculosis therapy against both replicating and persistent bacteria. ISBN:978-92-4-008241-0 PMID:35944069 PMID:36409105 Mtub_ddn_MULT Rv1877, a putative Major Facilitator Superfamily efflux pump from M. tuberculosis actively effluxes fluoroquinolones ofloxacin and levofloxacin. Rv1877 antibiotic_resistance ARO:3007662 Rv1877 ARO:3007662 Rv1877, a putative Major Facilitator Superfamily efflux pump from M. tuberculosis actively effluxes fluoroquinolones ofloxacin and levofloxacin. PMID:36125560 Rv1877 Stress-activated protein kinases (SAPK) are kinases involved in cellular response to stress whose absence confers resistance to antifungal drug compounds. antibiotic_resistance ARO:3007663 stress-activated protein kinases ARO:3007663 Stress-activated protein kinases (SAPK) are kinases involved in cellular response to stress whose absence confers resistance to antifungal drug compounds. PMID:30355673 Hog1 is a stress-activated protein kinase. Deletion of Hog1 confers resistance to caspofungin through increase in exposed chitin levels in the cell wall. antibiotic_resistance ARO:3007664 Candida spp. High Osmolarity Glycerol 1 conferring resistance to caspofungin via absence ARO:3007664 Hog1 is a stress-activated protein kinase. Deletion of Hog1 confers resistance to caspofungin through increase in exposed chitin levels in the cell wall. PMID:30355673 FCY2 encodes for purine-cytosine permease in fungal cells. Downregulation or absence of FCY2 confers resistance to antibiotics by preventing entry into the cell. antibiotic_resistance ARO:3007665 Candida spp. FCY2 conferring resistance to 5-flucytosine via reduced permeability ARO:3007665 Candida spp. cyp51A1 is a fungal cytochrome P450 enzyme with mutations in the gene causing triazole and imidazole resistance. antibiotic_resistance ARO:3007666 Candida spp. cyp51A1 with mutations conferring resistance to triazoles and imidazole antibiotics ARO:3007666 Candida spp. cyp51A1 is a fungal cytochrome P450 enzyme with mutations in the gene causing triazole and imidazole resistance. PMID:9527767 Fungal cytochrome P450 enzymes which include mutations to confer resistance to imidazole-class antibiotics. antibiotic_resistance ARO:3007667 imidazole-resistant fungal cytochrome P450 enzyme ARO:3007667 Fungal cytochrome P450 enzymes which include mutations to confer resistance to imidazole-class antibiotics. PMID:9527767 HMG-CoA reductase-encoding genes which include mutations to confer resistance to antifungal drug compounds. antibiotic_resistance ARO:3007668 HMG-CoA reductase-encoding genes ARO:3007668 HMG-CoA reductase-encoding genes which include mutations to confer resistance to antifungal drug compounds. PMID:30940706 The AadT pump is a novel multidrug efflux pump from the proton antiporter 2 (DHA2) family and was discovered in Acinetobacter multidrug resistance plasmids. The presence of AadT decreased bacterial susceptibility to antibiotics (erythromycin and tetracycline), biocides (chlorhexidine), and dyes (ethidium bromide and DAPI) and was able to mediate ethidium transport. aadT antibiotic_resistance ARO:3007669 aadT ARO:3007669 The AadT pump is a novel multidrug efflux pump from the proton antiporter 2 (DHA2) family and was discovered in Acinetobacter multidrug resistance plasmids. The presence of AadT decreased bacterial susceptibility to antibiotics (erythromycin and tetracycline), biocides (chlorhexidine), and dyes (ethidium bromide and DAPI) and was able to mediate ethidium transport. PMID:37252766 aadT Hmg1 is an HMG-CoA reductase-encoding gene with mutations in the gene causing triazole resistance. antibiotic_resistance ARO:3007670 Aspergillus spp. Hmg1 with mutations conferring resistance to triazoles antibiotics ARO:3007670 Hmg1 is an HMG-CoA reductase-encoding gene with mutations in the gene causing triazole resistance. PMID:30940706 Clostridioides difficile nimB is a heme-dependent flavin enzyme that degrades nitroimidazoles to amines lacking antimicrobial activity. NimB expression alone is not sufficient for nitroimidazole resistance. Constitutive transcription of nimB, which is driven by a mutation in the promoter PnimBG, is a mechanism of clinically-relevant heme-dependent metronidazole resistance in C. difficile. C. difficile nimB CdnimB antibiotic_resistance ARO:3007671 Clostridioides difficile nimB ARO:3007671 Clostridioides difficile nimB is a heme-dependent flavin enzyme that degrades nitroimidazoles to amines lacking antimicrobial activity. NimB expression alone is not sufficient for nitroimidazole resistance. Constitutive transcription of nimB, which is driven by a mutation in the promoter PnimBG, is a mechanism of clinically-relevant heme-dependent metronidazole resistance in C. difficile. PMID:37438331 CdnimB Rv0678 encodes a transcription factor which negatively regulates the expression of the mmpS5/L5 efflux pump. antibiotic_resistance ARO:3007672 antibiotic resistant Rv0678 ARO:3007672 Rv0678 encodes a transcription factor which negatively regulates the expression of the mmpS5/L5 efflux pump. PMID:37280265 Loss-of-function mutations in the Mycobacterium Rv0678 gene associated with bedaquiline resistance. antibiotic_resistance ARO:3007673 bedaquiline resistant Rv0678 ARO:3007673 Loss-of-function mutations in the Mycobacterium Rv0678 gene associated with bedaquiline resistance. PMID:37280265 Rv0678 encodes a transcription factor which negatively regulates the expression of the mmpS5/L5 efflux pump. Loss-of-function mutations in rv0678 are a common mechanism of resistance. Mtub_Rv0678_BDQ Rv0678 antibiotic_resistance ARO:3007674 Mycobacterium tuberculosis Rv0678 with mutation conferring resistance to bedaquiline ARO:3007674 Rv0678 encodes a transcription factor which negatively regulates the expression of the mmpS5/L5 efflux pump. Loss-of-function mutations in rv0678 are a common mechanism of resistance. ISBN:978-92-4-008241-0 PMID:35944069 PMID:37280265 Mtub_Rv0678_BDQ Famotidine enhances the antibacterial activity of rifamycin antibiotics, especially rifampicin, against Gram-negative bacteria and reverses drug resistance. Famotidine disrupts the cell membrane of A. baumannii and inhibits the expression of the outer membrane protein ompA gene, while causing a dissipation of the plasma membrane potential which increases the accumulation of reactive oxygen species leading to increased bacterial mortality. Famotidine also inhibited the efflux pump activity and the biofilm formation of A. baumannii. CAS:76824-35-6 ChEBI:4975 ChEMBL:CHEMBL902 PubChem:5702160 antibiotic_resistance ARO:3007675 famotidine ARO:3007675 Famotidine enhances the antibacterial activity of rifamycin antibiotics, especially rifampicin, against Gram-negative bacteria and reverses drug resistance. Famotidine disrupts the cell membrane of A. baumannii and inhibits the expression of the outer membrane protein ompA gene, while causing a dissipation of the plasma membrane potential which increases the accumulation of reactive oxygen species leading to increased bacterial mortality. Famotidine also inhibited the efflux pump activity and the biofilm formation of A. baumannii. PMID:37439688 Furazidin is a nitrofuran derivative, acting as an antibacterial medicine with bacteriostatic action. It is active against both gram-positive and gram-negative bacteria. It is used for the treatment of urinary tract, skin, and soft tissues infections. CAS:1672-88-4 ChEBI:131714 ChEMBL:CHEMBL3707254 PubChem:6870646 furagin furazidine antibiotic_resistance ARO:3007677 furazidin ARO:3007677 Furazidin is a nitrofuran derivative, acting as an antibacterial medicine with bacteriostatic action. It is active against both gram-positive and gram-negative bacteria. It is used for the treatment of urinary tract, skin, and soft tissues infections. PMID:37629208 E. faecalis IreK maintains cell wall integrity, possibly by regulating peptidoglycan biosynthesis and metabolism. Antibiotic-induced cell wall stress leads to activation of IreK-mediated phosphorylation signaling pathways to mitigate and repair the damage. Absence of IreK leads to cell envelope defects and increased susceptibility to a variety of cephalosporins, including ceftriaxone. Increased IreK phosphorylation in response to ceftriaxone treatment has been shown to correlate with antimicrobial resistance. IreK antibiotic_resistance ARO:3007678 IreK ARO:3007678 E. faecalis IreK maintains cell wall integrity, possibly by regulating peptidoglycan biosynthesis and metabolism. Antibiotic-induced cell wall stress leads to activation of IreK-mediated phosphorylation signaling pathways to mitigate and repair the damage. Absence of IreK leads to cell envelope defects and increased susceptibility to a variety of cephalosporins, including ceftriaxone. Increased IreK phosphorylation in response to ceftriaxone treatment has been shown to correlate with antimicrobial resistance. PMID:34672600 PMID:37517789 IreK Chrysomycin A (ChryA) is a benzonaphthopyranone glycoside with rapid bactericidal activity that is highly active against S. aureus persisters, robustly eradicates biofilms in vitro, and shows a sustainable killing efficacy in vivo. Chrysomycin A belongs to the coumarin class of antibiotics which are known to bind gyrase subunit B and inhibit the enzyme function. ChEBI:191084 PubChem:73468 ChryA antibiotic_resistance ARO:3007679 chrysomycin A ARO:3007679 Chrysomycin A (ChryA) is a benzonaphthopyranone glycoside with rapid bactericidal activity that is highly active against S. aureus persisters, robustly eradicates biofilms in vitro, and shows a sustainable killing efficacy in vivo. Chrysomycin A belongs to the coumarin class of antibiotics which are known to bind gyrase subunit B and inhibit the enzyme function. PMID:37540745 2,4-diacetylphloroglucinol (DAPG) is a broad-spectrum antibiotic that was originally isolated from a fluorescent Pseudomonas strain. DAPG is active against numerous organisms, including plants, fungi, viruses, bacteria, and nematodes, and production or increased production of DAPG has been associated with enhanced activity against plant pathogens. CAS:2161-86-6 ChEBI:78688 ChEMBL:CHEMBL276139 PubChem:16547 DAPG antibiotic_resistance ARO:3007680 2,4-diacetylphloroglucinol ARO:3007680 2,4-diacetylphloroglucinol (DAPG) is a broad-spectrum antibiotic that was originally isolated from a fluorescent Pseudomonas strain. DAPG is active against numerous organisms, including plants, fungi, viruses, bacteria, and nematodes, and production or increased production of DAPG has been associated with enhanced activity against plant pathogens. PMID:37653049 MdtQ is a putative multidrug resistance outer membrane protein found in carbapenem-resistant Klebsiella pneumoniae. MdtQ antibiotic_resistance ARO:3007682 MdtQ ARO:3007682 MdtQ is a putative multidrug resistance outer membrane protein found in carbapenem-resistant Klebsiella pneumoniae. PMID:37640276 MdtQ The eukaryotic-type Ser/Thr kinase (STKs) IreK (intrinsic resistance of enterococci kinase) belongs to a family of transmembrane kinases defined by the presence of multiple extracellular PASTA (penicillin-binding protein and serine/threonine kinase associated) domains. In prokaryotes, STKs modulate cellular functions such as growth, differentiation, and secondary metabolism. When the external environment changes, prokaryotes rely on signal transduction systems, including STKs that quickly sense these changes and alter gene expression to induce the appropriate metabolic changes. STK ser/thr kineases antibiotic_resistance ARO:3007683 Serine/threonine kinases ARO:3007683 The eukaryotic-type Ser/Thr kinase (STKs) IreK (intrinsic resistance of enterococci kinase) belongs to a family of transmembrane kinases defined by the presence of multiple extracellular PASTA (penicillin-binding protein and serine/threonine kinase associated) domains. In prokaryotes, STKs modulate cellular functions such as growth, differentiation, and secondary metabolism. When the external environment changes, prokaryotes rely on signal transduction systems, including STKs that quickly sense these changes and alter gene expression to induce the appropriate metabolic changes. PMID:22045988 PMID:28698584 PMID:34672600 Mutations in mgrB transmembrane proteins can confer resistance to the antibiotic colistin. antibiotic_resistance ARO:3007684 transmembrane protein conferring colistin resistance ARO:3007684 Mutations in mgrB transmembrane proteins can confer resistance to the antibiotic colistin. PMID:25190723 Nifuratel is a nitrofuran antibiotic already in use for parasitic infections. It was effective against different serovars, including multidrug-resistant strains of Salmonella Typhimurium, and in macrophages from different host species and against Listeria monocytogenes and Shigella flexneri. It reduced IL-10 and STAT3 production in infected macrophages which should increase the inflammatory response against Salmonella. CAS:4936-47-4 ChEBI:135180 ChEMBL:CHEMBL514315 PubChem:6433427 antibiotic_resistance ARO:3007685 nifuratel ARO:3007685 Nifuratel is a nitrofuran antibiotic already in use for parasitic infections. It was effective against different serovars, including multidrug-resistant strains of Salmonella Typhimurium, and in macrophages from different host species and against Listeria monocytogenes and Shigella flexneri. It reduced IL-10 and STAT3 production in infected macrophages which should increase the inflammatory response against Salmonella. PMID:37732770 Mutanobactin is produced by a polyketide synthase-nonribosomal peptide synthetase hybrid system encoded by the mub locus. Mutanobactin-producing S. mutans inhibits planktonic and biofilm growth of E. faecalis and is active against other Enterococcus species and Staphylococcus aureus. ChEBI:212062 PubChem:49850903 antibiotic_resistance ARO:3007686 mutanobactin ARO:3007686 Mutanobactin is produced by a polyketide synthase-nonribosomal peptide synthetase hybrid system encoded by the mub locus. Mutanobactin-producing S. mutans inhibits planktonic and biofilm growth of E. faecalis and is active against other Enterococcus species and Staphylococcus aureus. PMID:37745448 Zidovudine is an antibiotic used in the management and treatment of HIV-1. It is in the nucleoside reverse transcriptase inhibitor class of medications. CAS:30516-87-1 ChEBI:10110 ChEMBL:CHEMBL129 PubChem:35370 azidothymidine antibiotic_resistance ARO:3007687 zidovudine ARO:3007687 Zidovudine is an antibiotic used in the management and treatment of HIV-1. It is in the nucleoside reverse transcriptase inhibitor class of medications. PMID:37660210 Menadione exhibits antibacterial activity against methicillin-sensitive and methicillin-resistant S. aureus strains. When combined with oxacillin, it exhibited an additive and synergistic effect against the tested strains. Menadione demonstrated antibiofilm activity and effectively combated biofilms with reduced sensitivity to oxacillin alone. Its mechanism of action involves the production of reactive oxygen species (ROS) and DNA damage. It showed interactions with important targets, such as DNA gyrase and dehydroesqualene synthase. CAS:58-27-5 ChEBI:28869 ChEMBL:CHEMBL590 PubChem:4055 vitamin K3 antibiotic_resistance ARO:3007688 menadione ARO:3007688 Menadione exhibits antibacterial activity against methicillin-sensitive and methicillin-resistant S. aureus strains. When combined with oxacillin, it exhibited an additive and synergistic effect against the tested strains. Menadione demonstrated antibiofilm activity and effectively combated biofilms with reduced sensitivity to oxacillin alone. Its mechanism of action involves the production of reactive oxygen species (ROS) and DNA damage. It showed interactions with important targets, such as DNA gyrase and dehydroesqualene synthase. PMID:37707372 Selamectin is a topical antiparasitic medication for dogs and cats prescribed for various parasite infections. Exposure caused relevant cell surface alterations. A synergistic effect was observed between ampicillin and selamectin. Selamectin may represent a timely and promising macrocyclic lactone for the treatment of S. aureus infections. CAS:165108-07-6 ChEBI:177562 ChEMBL:CHEMBL1908325 PubChem:9578507 antibiotic_resistance ARO:3007689 selamectin ARO:3007689 Selamectin is a topical antiparasitic medication for dogs and cats prescribed for various parasite infections. Exposure caused relevant cell surface alterations. A synergistic effect was observed between ampicillin and selamectin. Selamectin may represent a timely and promising macrocyclic lactone for the treatment of S. aureus infections. PMID:37764086 Rv2535c or pepQ encodes a putative Xaa-Pro aminopeptidase and is a new genetic determinant of low-level bedaquiline and clofazimine cross-resistance in Mycobacterium tuberculosis when mutated. antibiotic_resistance ARO:3007690 antibiotic resistant Rv2535c ARO:3007690 Rv2535c or pepQ encodes a putative Xaa-Pro aminopeptidase and is a new genetic determinant of low-level bedaquiline and clofazimine cross-resistance in Mycobacterium tuberculosis when mutated. PMID:27185800 Loss-of-function mutations in Rv2535c are a common mechanism of resistance. antibiotic_resistance ARO:3007691 bedaquiline resistant Rv2535c ARO:3007691 Loss-of-function mutations in Rv2535c are a common mechanism of resistance. PMID:27185800 These pepQ/Rv2535c mutations increase efflux through the mmpL5-mmpS5 (Rv0676c-Rv0677c) transporter, such as preventing degradation of MmpL5, which leads to reduced susceptibility to bedaquiline and clofazimine. Mtub_Rv2535_BDQ Rv2535c pepQ antibiotic_resistance ARO:3007692 Mycobacterium tuberculosis Rv2535c with mutation conferring resistance to bedaquiline ARO:3007692 These pepQ/Rv2535c mutations increase efflux through the mmpL5-mmpS5 (Rv0676c-Rv0677c) transporter, such as preventing degradation of MmpL5, which leads to reduced susceptibility to bedaquiline and clofazimine. PMID:27185800 Mtub_Rv2535_BDQ The AMZ genes showed resistance against some beta-lactam antibiotics, including amoxicillin and cephalothin, and the beta-lactamase AMZ-1 exhibited a similar substrate spectrum response. Similar to other AmpC beta-lactamases, AMZ-1 is strongly inhibited by avibactam but much less strongly inhibited by tazobactam. antibiotic_resistance ARO:3007693 AMZ beta-lactamase ARO:3007693 The AMZ genes showed resistance against some beta-lactam antibiotics, including amoxicillin and cephalothin, and the beta-lactamase AMZ-1 exhibited a similar substrate spectrum response. Similar to other AmpC beta-lactamases, AMZ-1 is strongly inhibited by avibactam but much less strongly inhibited by tazobactam. PMID:37808287 Achromobacter mucicolens Y3, isolated from a goose on a farm in Wenzhou, showed resistance to multiple antibiotics, including penicillins and cephalosporins. AMZ-1 showed resistance to amoxicillin, penicillin G, ampicillin, cephalothin and cefoxitin, and the resistance activity could be inhibited by beta-lactamase inhibitors. AMZ-1 antibiotic_resistance ARO:3007694 AMZ-1 ARO:3007694 Achromobacter mucicolens Y3, isolated from a goose on a farm in Wenzhou, showed resistance to multiple antibiotics, including penicillins and cephalosporins. AMZ-1 showed resistance to amoxicillin, penicillin G, ampicillin, cephalothin and cefoxitin, and the resistance activity could be inhibited by beta-lactamase inhibitors. PMID:37808287 AMZ-1 We identified ceftazidime/avibactam resistance in E. coli associated with a novel CMY variant. Unlike other AmpC enzymes, CMY-185 appears to require an additional substitution on top of N346Y to confer ceftazidime/avibactam resistance. CMY-185 antibiotic_resistance ARO:3007695 CMY-185 ARO:3007695 We identified ceftazidime/avibactam resistance in E. coli associated with a novel CMY variant. Unlike other AmpC enzymes, CMY-185 appears to require an additional substitution on top of N346Y to confer ceftazidime/avibactam resistance. PMID:37574665 CMY-185 A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-1. antibiotic_resistance ARO:3007696 OXA-1-like beta-lactamase ARO:3007696 A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-10. antibiotic_resistance ARO:3007697 OXA-10-like beta-lactamase ARO:3007697 A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-114. antibiotic_resistance ARO:3007698 OXA-114-like beta-lactamase ARO:3007698 A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-12. antibiotic_resistance ARO:3007699 OXA-12-like beta-lactamase ARO:3007699 A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-134. antibiotic_resistance ARO:3007700 OXA-134-like beta-lactamase ARO:3007700 A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-143. antibiotic_resistance ARO:3007701 OXA-143-like beta-lactamase ARO:3007701 A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-184. antibiotic_resistance ARO:3007702 OXA-184-like beta-lactamase ARO:3007702 A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-198. antibiotic_resistance ARO:3007703 OXA-198-like beta-lactamase ARO:3007703 A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-2. antibiotic_resistance ARO:3007704 OXA-2-like beta-lactamase ARO:3007704 A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-211. antibiotic_resistance ARO:3007705 OXA-211-like beta-lactamase ARO:3007705 OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect. antibiotic_resistance ARO:3007706 OXA-213-like beta-lactamase ARO:3007706 OXA-213-like enzymes have been identified to be intrinsic to A. calcoaceticus and have been subsequently detected in A. pittii. Phylogenetic analysis of OXA-213-like proteins identified two distinct subgroups within the OXA family. The first group was linked to A. pittii and the second group to A. calcoaceticus. The carbapenemase activity of these OXAs may be related to the species-dependent effect. PMID:24696435 A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-214. antibiotic_resistance ARO:3007707 OXA-214-like beta-lactamase ARO:3007707 A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-22. antibiotic_resistance ARO:3007708 OXA-22-like beta-lactamase ARO:3007708 A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-229. antibiotic_resistance ARO:3007709 OXA-229-like beta-lactamase ARO:3007709 A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases, specifically imipenem, derived from OXA-23, first identified in Acinetobacter baumannii. antibiotic_resistance ARO:3007710 OXA-23-like beta-lactamase ARO:3007710 A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-24. antibiotic_resistance ARO:3007711 OXA-24-like beta-lactamase ARO:3007711 A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-266. antibiotic_resistance ARO:3007712 OXA-266-like beta-lactamase ARO:3007712 A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-274. antibiotic_resistance ARO:3007713 OXA-274-like beta-lactamase ARO:3007713 A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-286. antibiotic_resistance ARO:3007714 OXA-286-like beta-lactamase ARO:3007714 A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-294. antibiotic_resistance ARO:3007715 OXA-294-like beta-lactamase ARO:3007715 A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-364. antibiotic_resistance ARO:3007716 OXA-364-like beta-lactamase ARO:3007716 A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-372. antibiotic_resistance ARO:3007717 OXA-372-like beta-lactamase ARO:3007717 A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-42. antibiotic_resistance ARO:3007718 OXA-42-like beta-lactamase ARO:3007718 A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-427. antibiotic_resistance ARO:3007719 OXA-427-like beta-lactamase ARO:3007719 A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-46. antibiotic_resistance ARO:3007720 OXA-46-like beta-lactamase ARO:3007720 OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins. antibiotic_resistance ARO:3007721 OXA-48-like beta-lactamase ARO:3007721 OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins. PMID:33753332 A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-493. antibiotic_resistance ARO:3007722 OXA-493-like beta-lactamase ARO:3007722 A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-5. antibiotic_resistance ARO:3007723 OXA-5-like beta-lactamase ARO:3007723 A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-50. antibiotic_resistance ARO:3007724 OXA-50-like beta-lactamase ARO:3007724 The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance. antibiotic_resistance ARO:3007725 OXA-51-like beta-lactamase ARO:3007725 The maximum number of blaOXA belonged to the OXA-51-like subfamily. An earlier study had reported that OXA-51-like enzymes were present exclusively in A. baumannii. Similar to most of the other OXA-type carbapenemases, the OXA-51-like enzymes show weak carbapenemase activity; however, the presence of the insertion sequence ISAba1 upstream of the blaOXA-51-like gene may provide a promoter that allows the overproduction of carbapenemase, and this results in carbapenem resistance. PMID:17724156 PMID:24696435 A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-548. antibiotic_resistance ARO:3007726 OXA-548-like beta-lactamase ARO:3007726 A subfamily of carbapanem-hydrolyzing class D OXA beta-lactamases derived from OXA-55. antibiotic_resistance ARO:3007727 OXA-55-like beta-lactamase ARO:3007727 A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-58. antibiotic_resistance ARO:3007728 OXA-58-like beta-lactamase ARO:3007728 A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-60. antibiotic_resistance ARO:3007729 OXA-60-like beta-lactamase ARO:3007729 A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-61. antibiotic_resistance ARO:3007730 OXA-61-like beta-lactamase ARO:3007730 A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-62. antibiotic_resistance ARO:3007731 OXA-62-like beta-lactamase ARO:3007731 A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-63. antibiotic_resistance ARO:3007732 OXA-63-like beta-lactamase ARO:3007732 A subfamily of carbapenem-hydrolyzing class D OXA beta-lactamases derived from OXA-679. antibiotic_resistance ARO:3007733 OXA-679-like beta-lactamase ARO:3007733 A subfamily of extended-spectrum oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-727. antibiotic_resistance ARO:3007734 OXA-727-like beta-lactamase ARO:3007734 A subfamily of oxacillin-hydrolyzing class D OXA beta-lactamases derived from OXA-9. antibiotic_resistance ARO:3007735 OXA-9-like beta-lactamase ARO:3007735 Dexrazoxane is a medication used in the management and treatment of anthracycline-induced cardiotoxicity and extravasation injuries. It was demonstrated to inhibit all tested metallo-beta-lactamases and showed an in vitro synergistic bactericidal effect with meropenem against metallo-beta-lactamases-producing bacteria. Dexrazoxane is a metal ion chelating agent. CAS:24584-09-6 ChEBI:50223 ChEMBL:CHEMBL1738 PubChem:71384 antibiotic_resistance ARO:3007736 dexrazoxane ARO:3007736 Dexrazoxane is a medication used in the management and treatment of anthracycline-induced cardiotoxicity and extravasation injuries. It was demonstrated to inhibit all tested metallo-beta-lactamases and showed an in vitro synergistic bactericidal effect with meropenem against metallo-beta-lactamases-producing bacteria. Dexrazoxane is a metal ion chelating agent. PMID:37539785 Nordihydroguaiaretic acid (NDGA) is a phenolic lignan obtained from Larrea tridentata that has been used in traditional medicine for the treatment of diseases such as cancer, renal, cardiovascular, immunological, and neurological disorders, and even aging. The inhibition of NDM-1 by nordihydroguaiaretic acid involves its direct binding to the active region of NDM-1. CAS:500-38-9 ChEBI:7625 ChEMBL:CHEMBL52 PubChem:4534 antibiotic_resistance ARO:3007745 nordihydroguaiaretic acid ARO:3007745 Nordihydroguaiaretic acid (NDGA) is a phenolic lignan obtained from Larrea tridentata that has been used in traditional medicine for the treatment of diseases such as cancer, renal, cardiovascular, immunological, and neurological disorders, and even aging. The inhibition of NDM-1 by nordihydroguaiaretic acid involves its direct binding to the active region of NDM-1. PMID:37539785 Embelin is a naturally occurring para-benzoquinone isolated from dried berries of Embelia ribes plants. Embelin has a wide spectrum of biological activities, including antioxidant, antitumor, anti-inflammatory, analgesic, anthelmintic, antifertility and antimicrobial. It was demonstrated to inhibit all tested metallo-beta-lactamases and showed an in vitro synergistic bactericidal effect with meropenem against metallo-beta-lactamases-producing bacteria. Embelin is a metal ion chelating agent. CAS:550-24-3 ChEBI:4778 ChEMBL:CHEMBL221137 PubChem:3218 antibiotic_resistance ARO:3007746 embelin ARO:3007746 Embelin is a naturally occurring para-benzoquinone isolated from dried berries of Embelia ribes plants. Embelin has a wide spectrum of biological activities, including antioxidant, antitumor, anti-inflammatory, analgesic, anthelmintic, antifertility and antimicrobial. It was demonstrated to inhibit all tested metallo-beta-lactamases and showed an in vitro synergistic bactericidal effect with meropenem against metallo-beta-lactamases-producing bacteria. Embelin is a metal ion chelating agent. PMID:37539785 Candesartan is an anti-hypertensive drug that was found to have antibacterial activity against MDR S. aureus. It was demonstrated to inhibit all tested metallo-beta-lactamases and showed an in vitro synergistic bactericidal effect with meropenem against metallo-beta-lactamases-producing bacteria. Candesartan is a metal ion chelating agent. CAS:145040-37-5 ChEBI:3348 ChEMBL:CHEMBL1014 PubChem:2540 antibiotic_resistance ARO:3007747 candesartan cilexetil ARO:3007747 Candesartan is an anti-hypertensive drug that was found to have antibacterial activity against MDR S. aureus. It was demonstrated to inhibit all tested metallo-beta-lactamases and showed an in vitro synergistic bactericidal effect with meropenem against metallo-beta-lactamases-producing bacteria. Candesartan is a metal ion chelating agent. PMID:37539785 The small proline-rich antimicrobial peptide, oncocin, selectively targets Gram-negative bacteria through special transporters such as SmbA to enter cytoplasm. It presents low toxicity to mammalian cells, because they cannot effectively penetrate the mammalian cellular membrane or they are internalized through an endocytotic process to minimize interaction with cytosolic ribosomes. ChEMBL:CHEMBL1083466 PubChem:46889826 antibiotic_resistance ARO:3007748 oncocin ARO:3007748 The small proline-rich antimicrobial peptide, oncocin, selectively targets Gram-negative bacteria through special transporters such as SmbA to enter cytoplasm. It presents low toxicity to mammalian cells, because they cannot effectively penetrate the mammalian cellular membrane or they are internalized through an endocytotic process to minimize interaction with cytosolic ribosomes. PMID:29256010 PMID:37797458 Point mutations in Salmonella gallinarum dihydropteroate synthase folP altered the stability of the protein, thus conferring sulfonamide resistance. Sgal_folP_SLF antibiotic_resistance ARO:3007749 Salmonella gallinarum folP with mutation conferring resistance to sulfonamides ARO:3007749 Point mutations in Salmonella gallinarum dihydropteroate synthase folP altered the stability of the protein, thus conferring sulfonamide resistance. PMID:37906281 Sgal_folP_SLF Betaxolol is a selective beta1 receptor blocker used in the treatment of hypertension and angina, with a 50% inhibitory concentration (IC50) of 19.3 plus or minus 0.9 uM significantly inhibiting the hydrolytic activity of the NDM-1 enzyme and may represent a potential NDM-1 enzyme inhibitor. BET combined with meropenem (MEM) showed bactericidal synergism in vitro. BET inhibited NDM-1 by competitively binding to it and that it can be developed in combination with MEM as a new therapy. CAS:63659-18-7 ChEBI:3082 ChEMBL:CHEMBL423 PubChem:2369 antibiotic_resistance ARO:3007750 betaxolol ARO:3007750 Betaxolol is a selective beta1 receptor blocker used in the treatment of hypertension and angina, with a 50% inhibitory concentration (IC50) of 19.3 plus or minus 0.9 uM significantly inhibiting the hydrolytic activity of the NDM-1 enzyme and may represent a potential NDM-1 enzyme inhibitor. BET combined with meropenem (MEM) showed bactericidal synergism in vitro. BET inhibited NDM-1 by competitively binding to it and that it can be developed in combination with MEM as a new therapy. PMID:37686201 Point mutations in Salmonella gyrA that confer resistance to ciprofloxacin and nalidixic acid which are fluoroquinolone antibiotics. Sisa_gyrA_FLO antibiotic_resistance ARO:3007751 Salmonella isangi gyrA conferring resistance to fluoroquinolones ARO:3007751 Point mutations in Salmonella gyrA that confer resistance to ciprofloxacin and nalidixic acid which are fluoroquinolone antibiotics. PMID:37627729 Sisa_gyrA_FLO Point mutation in Salmonella isangi resulting in fluoroquinolone resistance. Sisa_gyrB_FLO antibiotic_resistance ARO:3007752 Salmonella isangi gyrB conferring resistance to fluoroquinolones ARO:3007752 Point mutation in Salmonella isangi resulting in fluoroquinolone resistance. PMID:37627729 Sisa_gyrB_FLO Lasalocid is an antibacterial agent and a coccidiostat, which is produced by strains of Streptomyces lasaliensis. Lasalocid is able to make neutral complexes with monovalent and divalent cations and transport them through apolar phase. CAS:25999-31-9 ChEBI:92181 ChEMBL:CHEMBL145347 PubChem:5360807 Lasalocid Lasalocide antibiotic_resistance ARO:3007754 Lasalocid A ARO:3007754 Lasalocid is an antibacterial agent and a coccidiostat, which is produced by strains of Streptomyces lasaliensis. Lasalocid is able to make neutral complexes with monovalent and divalent cations and transport them through apolar phase. PMID:38069118 Calcimycin (A23187) is a polyether antibiotic and divalent cation ionophore, extracted from Streptomyces chartrecensis. CAS:52665-69-7 ChEBI:3305 ChEMBL:CHEMBL1256686 PubChem:11957499 A23187 antibiotic_resistance ARO:3007755 Calcimycin ARO:3007755 Calcimycin (A23187) is a polyether antibiotic and divalent cation ionophore, extracted from Streptomyces chartrecensis. PMID:38103757 Ophiobolin A is a sesterterpene which was initially isolated as fungal phytotoxins and subsequently shown to possess other biological activities, including anticancer activities. CAS:4611-05-6 ChEBI:7777 ChEMBL:CHEMBL522808 PubChem:5281387 antibiotic_resistance ARO:3007756 ophiobolin A ARO:3007756 Ophiobolin A is a sesterterpene which was initially isolated as fungal phytotoxins and subsequently shown to possess other biological activities, including anticancer activities. PMID:38131643 Sphaeropsidin A is a tetracyclic pimarane diterpene, first isolated as the main phytotoxin produced by Diplodia cupressir, the causal agent of a severe canker disease of Italian cypress, Cupressus sempervirens L. ChEBI:69494 ChEMBL:CHEMBL1834675 PubChem:51361447 antibiotic_resistance ARO:3007757 sphaeropsidin A ARO:3007757 Sphaeropsidin A is a tetracyclic pimarane diterpene, first isolated as the main phytotoxin produced by Diplodia cupressir, the causal agent of a severe canker disease of Italian cypress, Cupressus sempervirens L. PMID:38131643 Fengycin is an antifungal lipopeptide complex produced by Bacillus subtilis strain F-29-3. It inhibits filamentous fungi and is used as an agricultural fungicide. CAS:102577-03-7 ChEBI:29583 PubChem:443591 antibiotic_resistance ARO:3007758 fengycin ARO:3007758 Fengycin is an antifungal lipopeptide complex produced by Bacillus subtilis strain F-29-3. It inhibits filamentous fungi and is used as an agricultural fungicide. PMID:29376372 PMID:38092837 Point mutations in 23S rRNA of Treponema pallidum subsp. pallidum (T. pallidum), the noncultivable agent of syphilis, shown clinically to confer resistance to erythromycin, a macrolide antibiotic. Tpal_23S_ERY antibiotic_resistance ARO:3007759 Treponema pallidum 23S rRNA with mutation conferring resistance to erythromycin ARO:3007759 Point mutations in 23S rRNA of Treponema pallidum subsp. pallidum (T. pallidum), the noncultivable agent of syphilis, shown clinically to confer resistance to erythromycin, a macrolide antibiotic. PMID:10755994 PMID:15247355 PMID:19429763 Tpal_23S_ERY Tulathromycin is an antibacterial of the macrolide class of drugs. It is a 15-membered macrolide structure and considered a triamilide macrolide with three charged nitrogens. It is derived from azalide macrolides, such as azithromycin. CAS:217500-96-4 ChEBI:182495 ChEMBL:CHEMBL5314550 PubChem:9832301 antibiotic_resistance ARO:3007760 tulathromycin ARO:3007760 Tulathromycin is an antibacterial of the macrolide class of drugs. It is a 15-membered macrolide structure and considered a triamilide macrolide with three charged nitrogens. It is derived from azalide macrolides, such as azithromycin. PMID:16094557 Gamithromycin, a novel semi-synthetic macrolide, is approved for the treatment and prevention of bovine respiratory disease. It plays a bacteriostatic and bactericidal role by inhibiting the ribosomal 50S subunit. CAS:145435-72-9 ChEBI:195437 ChEMBL:CHEMBL2107342 PubChem:59364992 antibiotic_resistance ARO:3007761 gamithromycin ARO:3007761 Gamithromycin, a novel semi-synthetic macrolide, is approved for the treatment and prevention of bovine respiratory disease. It plays a bacteriostatic and bactericidal role by inhibiting the ribosomal 50S subunit. PMID:31680940 Tildipirosin, a 16-membered-ring macrolide antimicrobial, has recently been approved for the treatment of swine respiratory disease and bovine respiratory disease. This macrolide is extensively distributed to the site of respiratory infection followed by slow elimination. ChEMBL:CHEMBL3039509 PubChem:24860548 antibiotic_resistance ARO:3007762 tildipirosin ARO:3007762 Tildipirosin, a 16-membered-ring macrolide antimicrobial, has recently been approved for the treatment of swine respiratory disease and bovine respiratory disease. This macrolide is extensively distributed to the site of respiratory infection followed by slow elimination. PMID:29867911 Four antitumor-antibiotics of a new structure class, the marinomycins A-D (1-4), were isolated from the saline culture of a new group of marine actinomycetes. The structures of the marinomycins are unusual macrodiolides composed of dimeric 2-hydroxy-6-alkenyl-benzoic acid lactones with conjugated tetraene-pentahydroxy polyketide chains. antibiotic_resistance ARO:3007763 Marinomycin ARO:3007763 Four antitumor-antibiotics of a new structure class, the marinomycins A-D (1-4), were isolated from the saline culture of a new group of marine actinomycetes. The structures of the marinomycins are unusual macrodiolides composed of dimeric 2-hydroxy-6-alkenyl-benzoic acid lactones with conjugated tetraene-pentahydroxy polyketide chains. PMID:16448135 Marinomycin A is a member of a new class of bis-salicylate-containing polyene macrodiolides, which have potent antibiotic activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium. ChEBI:213454 ChEMBL:CHEMBL1241387 PubChem:129700316 antibiotic_resistance ARO:3007764 Marinomycin A ARO:3007764 Marinomycin A is a member of a new class of bis-salicylate-containing polyene macrodiolides, which have potent antibiotic activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium. PMID:16448135 Marinomycin B is a member of a new class of bis-salicylate-containing polyene macrodiolides, which have potent antibiotic activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium. ChEBI:221380 PubChem:11557098 antibiotic_resistance ARO:3007765 Marinomycin B ARO:3007765 Marinomycin B is a member of a new class of bis-salicylate-containing polyene macrodiolides, which have potent antibiotic activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium. PMID:16448135 Marinomycin C is a member of a new class of bis-salicylate-containing polyene macrodiolides, which have potent antibiotic activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium. PubChem:11240121 antibiotic_resistance ARO:3007766 Marinomycin C ARO:3007766 Marinomycin C is a member of a new class of bis-salicylate-containing polyene macrodiolides, which have potent antibiotic activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium. PMID:16448135 Marinomycin D is a member of a new class of bis-salicylate-containing polyene macrodiolides, which have potent antibiotic activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium. ChEBI:212156 PubChem:42617892 antibiotic_resistance ARO:3007767 Marinomycin D ARO:3007767 Marinomycin D is a member of a new class of bis-salicylate-containing polyene macrodiolides, which have potent antibiotic activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium. PMID:16448135 Tetronomycin, C34H50O8, isolated from a strain of Streptomyces sp. nov. represents a novel polycyclic ionophore polyether. ChEBI:220058 PubChem:44472823 antibiotic_resistance ARO:3007768 tetronomycin ARO:3007768 Tetronomycin, C34H50O8, isolated from a strain of Streptomyces sp. nov. represents a novel polycyclic ionophore polyether. PMID:7076564 Cezomycin is a polyether divalent cation ionophore secondary metabolite produced by Streptomyces chartreusis. ChEBI:223155 PubChem:134368 antibiotic_resistance ARO:3007769 cezomycin ARO:3007769 Cezomycin is a polyether divalent cation ionophore secondary metabolite produced by Streptomyces chartreusis. PMID:29654174 A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant, identified from Escherichia coli. These variants confers resistance to both aminoglycoside and fluoroquinolone antibiotics. aac(6')-Ib-cr10 antibiotic_resistance ARO:3007770 aac(6')-Ib-cr10 ARO:3007770 aac(6')-Ib-cr10 A fluoroquinolone-acetylating aminoglycoside acetyltransferase variant identified from Proteus mirabilis. These proteins confer resistance to both fluoroquinolone and aminoglycoside antibiotics. aac(6')-Ib-cr11 antibiotic_resistance ARO:3007771 aac(6')-Ib-cr11 ARO:3007771 aac(6')-Ib-cr11 Valinomycin is a depsipeptide antibiotic which selectively translocates potassium across biologic membranes. This potassium ionophore was observed to inhibit phytohemagglutinin-stimulated blastogenesis and proliferation in human lymphocytes. ChEBI:28545 ChEMBL:CHEMBL223643 PubChem:3000706 antibiotic_resistance ARO:3007772 valinomycin ARO:3007772 Valinomycin is a depsipeptide antibiotic which selectively translocates potassium across biologic membranes. This potassium ionophore was observed to inhibit phytohemagglutinin-stimulated blastogenesis and proliferation in human lymphocytes. PMID:1068473 Bisindoles are structurally complex dimers and are intriguing targets for partial and total synthesis. They exhibit stronger biological activity than their corresponding monomeric units. antibiotic_resistance ARO:3007773 bis-indole alkaloid with antibiotic activity ARO:3007773 Bisindoles are structurally complex dimers and are intriguing targets for partial and total synthesis. They exhibit stronger biological activity than their corresponding monomeric units. PMID:34200196 Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines. PubChem:11260315 antibiotic_resistance ARO:3007774 dragmacidin A ARO:3007774 Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines. PMID:28085024 PMID:38206835 Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines. ChEMBL:CHEMBL4159271 PubChem:14467479 antibiotic_resistance ARO:3007775 dragmacidin B ARO:3007775 Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines. PMID:28085024 PMID:38206835 Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines. ChEMBL:CHEMBL513753 PubChem:15000037 antibiotic_resistance ARO:3007776 dragmacidin D ARO:3007776 Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines. PMID:28085024 PMID:38206835 Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines. ChEMBL:CHEMBL472439 PubChem:135475363 antibiotic_resistance ARO:3007777 dragmacidin E ARO:3007777 Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines. PMID:28085024 PMID:38206835 Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines. ChEMBL:CHEMBL4079851 PubChem:459934 antibiotic_resistance ARO:3007778 dragmacidin F ARO:3007778 Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines. PMID:28085024 PMID:38206835 Three new cyclopeptides, including halolitoralin A (a cyclic hexapeptide), halolitoralin B and C (two cyclic tetrapeptides), were isolated from Halobacillus litoralis YS3106. antibiotic_resistance ARO:3007779 halolitoralin ARO:3007779 Three new cyclopeptides, including halolitoralin A (a cyclic hexapeptide), halolitoralin B and C (two cyclic tetrapeptides), were isolated from Halobacillus litoralis YS3106. PMID:34677431 Halolitoralin A is an alanine-rich cyclic hexapeptide. It exhibits potent activity against the pathogenic fungi Candida albicans and Trichophyton mentagrophytes and the gram negative bacteria Pseudomonas aeruginosa and Escherichia coli. Gram negative bacteria were found to be more sensitive than gram positive bacteria. It was also found to exhibit moderate anthelmintic activity against the earthworms Megascoplex konkanensis and Eudrilus sp. ChEBI:207984 PubChem:139588131 antibiotic_resistance ARO:3007780 halolitoralin A ARO:3007780 Halolitoralin A is an alanine-rich cyclic hexapeptide. It exhibits potent activity against the pathogenic fungi Candida albicans and Trichophyton mentagrophytes and the gram negative bacteria Pseudomonas aeruginosa and Escherichia coli. Gram negative bacteria were found to be more sensitive than gram positive bacteria. It was also found to exhibit moderate anthelmintic activity against the earthworms Megascoplex konkanensis and Eudrilus sp. PMID:34677431 Halolitoralin B is an alanine-rich cyclic hexapeptide. It exhibits potent activity against the pathogenic fungi Candida albicans and Trichophyton mentagrophytes and the gram negative bacteria Pseudomonas aeruginosa and Escherichia coli. Gram negative bacteria were found to be more sensitive than gram positive bacteria. It was also found to exhibit moderate anthelmintic activity against the earthworms Megascoplex konkanensis and Eudrilus sp. ChEBI:198143 PubChem:132493269 antibiotic_resistance ARO:3007781 halolitoralin B ARO:3007781 Halolitoralin B is an alanine-rich cyclic hexapeptide. It exhibits potent activity against the pathogenic fungi Candida albicans and Trichophyton mentagrophytes and the gram negative bacteria Pseudomonas aeruginosa and Escherichia coli. Gram negative bacteria were found to be more sensitive than gram positive bacteria. It was also found to exhibit moderate anthelmintic activity against the earthworms Megascoplex konkanensis and Eudrilus sp. PMID:34677431 Halolitoralin C is an alanine-rich cyclic hexapeptide. It exhibits potent activity against the pathogenic fungi Candida albicans and Trichophyton mentagrophytes and the gram negative bacteria Pseudomonas aeruginosa and Escherichia coli. Gram negative bacteria were found to be more sensitive than gram positive bacteria. It was also found to exhibit moderate anthelmintic activity against the earthworms Megascoplex konkanensis and Eudrilus sp. ChEBI:221356 PubChem:11812205 antibiotic_resistance ARO:3007782 halolitoralin C ARO:3007782 Halolitoralin C is an alanine-rich cyclic hexapeptide. It exhibits potent activity against the pathogenic fungi Candida albicans and Trichophyton mentagrophytes and the gram negative bacteria Pseudomonas aeruginosa and Escherichia coli. Gram negative bacteria were found to be more sensitive than gram positive bacteria. It was also found to exhibit moderate anthelmintic activity against the earthworms Megascoplex konkanensis and Eudrilus sp. PMID:34677431 Macrocyclic peptides are predominantly peptide structures bearing one or more rings and spanning multiple amino acid residues. Macrocyclization has become a common approach for improving the pharmacological properties and bioactivity of peptides. antibiotic_resistance ARO:3007783 macrocyclic peptide antibiotics ARO:3007783 Macrocyclic peptides are predominantly peptide structures bearing one or more rings and spanning multiple amino acid residues. Macrocyclization has become a common approach for improving the pharmacological properties and bioactivity of peptides. PMID:34206124 Zosurabalpin is a macrocyclic peptide (MCP) antibiotic with potent antibacterial activity against Carbapenem-resistant Acinetobacter baumannii. The mechanism of action involves blocking the transport of bacterial lipopolysaccharide from the inner membrane to its destination on the outer membrane, through inhibition of the LptB2FGC complex. ChEMBL:CHEMBL5314563 PubChem:148636827 antibiotic_resistance ARO:3007784 zosurabalpin ARO:3007784 Zosurabalpin is a macrocyclic peptide (MCP) antibiotic with potent antibacterial activity against Carbapenem-resistant Acinetobacter baumannii. The mechanism of action involves blocking the transport of bacterial lipopolysaccharide from the inner membrane to its destination on the outer membrane, through inhibition of the LptB2FGC complex. PMID:38172634 PMID:38453528 Nocardamine is a cyclic trihydroxamate. It belongs to a group of microbial siderophores which form complexes with iron and aluminum ions. Nocardamine was described first as an antibiotic active against mycobacteria and proteus. It is produced by Nocardia species, several Streptomyces species, Chromobacterium and Pseudomonas. ChEBI:50437 ChEMBL:CHEMBL505734 PubChem:161532 Deferrioxamine E nocardamin antibiotic_resistance ARO:3007785 nocardamine ARO:3007785 Nocardamine is a cyclic trihydroxamate. It belongs to a group of microbial siderophores which form complexes with iron and aluminum ions. Nocardamine was described first as an antibiotic active against mycobacteria and proteus. It is produced by Nocardia species, several Streptomyces species, Chromobacterium and Pseudomonas. PMID:31395970 PMID:38338462 Tartrolons are a group of boron-containing macrolide antibiotics discovered in 1994 from the culture broth of the myxobacterium Sorangium cellulosum. antibiotic_resistance ARO:3007786 Tartrolon ARO:3007786 Tartrolons are a group of boron-containing macrolide antibiotics discovered in 1994 from the culture broth of the myxobacterium Sorangium cellulosum. PMID:37804169 Tartrolons are a group of boron-containing (excluding tartrolon A) macrolide antibiotics discovered in 1994 from the culture broth of the myxobacterium Sorangium cellulosum. ChEBI:189235 ChEMBL:CHEMBL1076752 PubChem:10440589 antibiotic_resistance ARO:3007787 tartrolon A ARO:3007787 Tartrolons are a group of boron-containing (excluding tartrolon A) macrolide antibiotics discovered in 1994 from the culture broth of the myxobacterium Sorangium cellulosum. PMID:7532644 Tartrolons are a group of boron-containing (excluding tartrolon A) macrolide antibiotics discovered in 1994 from the culture broth of the myxobacterium Sorangium cellulosum. PubChem:23685389 antibiotic_resistance ARO:3007788 tartrolon B ARO:3007788 Tartrolons are a group of boron-containing (excluding tartrolon A) macrolide antibiotics discovered in 1994 from the culture broth of the myxobacterium Sorangium cellulosum. PMID:7532644 Tartrolons are a group of boron-containing (excluding tartrolon A) macrolide antibiotics discovered in 1994 from the culture broth of the myxobacterium Sorangium cellulosum. ChEBI:206040 ChEMBL:CHEMBL1076753 PubChem:44614261 antibiotic_resistance ARO:3007789 tartrolon D ARO:3007789 Tartrolons are a group of boron-containing (excluding tartrolon A) macrolide antibiotics discovered in 1994 from the culture broth of the myxobacterium Sorangium cellulosum. PMID:7532644 Tartrolons are a group of boron-containing (excluding tartrolon A) macrolide antibiotics discovered in 1994 from the culture broth of the myxobacterium Sorangium cellulosum. ChEBI:212069 PubChem:138320073 antibiotic_resistance ARO:3007790 tartrolon F ARO:3007790 Tartrolons are a group of boron-containing (excluding tartrolon A) macrolide antibiotics discovered in 1994 from the culture broth of the myxobacterium Sorangium cellulosum. PMID:7532644 Tartrolons are a group of boron-containing (excluding tartrolon A) macrolide antibiotics discovered in 1994 from the culture broth of the myxobacterium Sorangium cellulosum. ChEBI:212075 PubChem:138320074 antibiotic_resistance ARO:3007791 tartrolon G ARO:3007791 Tartrolons are a group of boron-containing (excluding tartrolon A) macrolide antibiotics discovered in 1994 from the culture broth of the myxobacterium Sorangium cellulosum. PMID:7532644 Aplasmomycin was isolated from a broth cultivated with a marine isolate of actinomycete, and inhibits Gram-positive bacteria in vitro and Plasmodium berghei in vivo. It is a natural ionophore. CAS:61230-25-9 ChEBI:32617 PubChem:23697358 antibiotic_resistance ARO:3007792 aplasmomycin ARO:3007792 Aplasmomycin was isolated from a broth cultivated with a marine isolate of actinomycete, and inhibits Gram-positive bacteria in vitro and Plasmodium berghei in vivo. It is a natural ionophore. PMID:30089869 Boromycin is a bacteriocidal polyether-macrolide antibiotic initially isolated from the Streptomyces antibioticus. It is effective against most Gram-positive bacteria, but is ineffective against Gram-negative bacteria. CAS:34524-20-4 ChEBI:77880 PubChem:6436027 antibiotic_resistance ARO:3007793 boromycin ARO:3007793 Boromycin is a bacteriocidal polyether-macrolide antibiotic initially isolated from the Streptomyces antibioticus. It is effective against most Gram-positive bacteria, but is ineffective against Gram-negative bacteria. PMID:30089869 Point mutations that occur within the Vibrio vulnificus rpoB gene resulting in resistance to rifampin. Vvul_rpoB_RIF antibiotic_resistance ARO:3007794 Vibrio vulnificus rpoB mutants conferring resistance to rifampin ARO:3007794 Point mutations that occur within the Vibrio vulnificus rpoB gene resulting in resistance to rifampin. PMID:37877661 Vvul_rpoB_RIF Azalomycin F, a natural guanidyl-containing polyhydroxy macrolide produced by many streptomycete strains, can target the LTA of Staphylococcus aureus. ChEMBL:CHEMBL2103834 PubChem:6450216 antibiotic_resistance ARO:3007795 Azalomycin F ARO:3007795 Azalomycin F, a natural guanidyl-containing polyhydroxy macrolide produced by many streptomycete strains, can target the LTA of Staphylococcus aureus. PMID:34770873 PMID:38398608 Tylvalosin is indicated for the control of porcine proliferative enteropathy associated with Lawsonia intracellularis infection in groups of swine. PubChem:6441094 antibiotic_resistance ARO:3007796 tylvalosin ARO:3007796 Tylvalosin is indicated for the control of porcine proliferative enteropathy associated with Lawsonia intracellularis infection in groups of swine. PMID:34729086 ampR is a LysR-type transcriptional regulator for beta-lactamase-encoding gene expression. Mutations in ampR of certain organisms have been shown to confer resistance to antibiotics due to beta-lactamase overexpression. antibiotic_resistance ARO:3007797 ampR transcriptional regulator with mutation conferring resistance to monobactam antibiotics ARO:3007797 ampR is a LysR-type transcriptional regulator for beta-lactamase-encoding gene expression. Mutations in ampR of certain organisms have been shown to confer resistance to antibiotics due to beta-lactamase overexpression. PMID:37070974 Known mutations in Mycobacterium tuberculosis iniA which confer resistance to isoniazid. Mtub_iniA_INH antibiotic_resistance ARO:3007798 Mycobacterium tuberculosis iniA mutations conferring resistance to isoniazid ARO:3007798 Known mutations in Mycobacterium tuberculosis iniA which confer resistance to isoniazid. PMID:12654653 Mtub_iniA_INH Mutations that occurs on the iniA genes resulting in the resistance to isoniazid. antibiotic_resistance ARO:3007799 isoniazid resistant iniA ARO:3007799 RATA is a family of class A carbapenemases identified from the chromosome of Riemerella anatipestifer. antibiotic_resistance ARO:3007800 RATA beta-lactamase ARO:3007800 RATA is a family of class A carbapenemases identified from the chromosome of Riemerella anatipestifer. PMID:38692330 RATA-1 is a class A RATA-family carbapenemase. RATA-1 antibiotic_resistance ARO:3007801 RATA-1 ARO:3007801 RATA-1 is a class A RATA-family carbapenemase. PMID:38692330 RATA-1 RATA-2 is a class A RATA-family carbapenemase. RATA-2 antibiotic_resistance ARO:3007802 RATA-2 ARO:3007802 RATA-2 is a class A RATA-family carbapenemase. PMID:38692330 RATA-2 CARB-56 is a class A CARB-17-like beta-lactamase identified from Vibrio alginolyticus. CARB-56 antibiotic_resistance ARO:3007803 CARB-56 ARO:3007803 CARB-56 VIM-74 is a subclass B1 carbapenem-hydrolyzing metallo-beta-lactamase. VIM-74 antibiotic_resistance ARO:3007804 VIM-74 ARO:3007804 VIM-74 Specific mutations in Mycobacterium tuberculosis tlyA resulting in resistance to capreomycin. Mtub_tlyA_CAP Rv1694 antibiotic_resistance ARO:3007805 Mycobacterium tuberculosis tlyA mutations conferring resistance to capreomycin ARO:3007805 Specific mutations in Mycobacterium tuberculosis tlyA resulting in resistance to capreomycin. ISBN:978-92-4-008241-0 Mtub_tlyA_CAP Specific mutations in Mycobacterium tuberculosis gyrA resulting in resistance to moxifloxacin. Mtub_gyrA_MXF Rv0006 antibiotic_resistance ARO:3007806 Mycobacterium tuberculosis gyrA mutations conferring resistance to moxifloxacin ARO:3007806 Mtub_gyrA_MXF Specific mutations in Mycobacterium tuberculosis gyrA resulting in resistance to ofloxacin. Mtub_gyrA_OFX Rv0006 antibiotic_resistance ARO:3007807 Mycobacterium tuberculosis gyrA mutations conferring resistance to ofloxacin ARO:3007807 Mtub_gyrA_OFX Specific mutations in Mycobacterium tuberculosis gyrB resulting in resistance to ofloxacin. Mtub_gyrB_OFX Rv0005 antibiotic_resistance ARO:3007808 Mycobacterium tuberculosis gyrB mutations conferring resistance to ofloxacin ARO:3007808 Mtub_gyrB_OFX Specific mutations in Mycobacterium tuberculosis gyrA resulting in resistance to levofloxacin. Rv0006 antibiotic_resistance ARO:3007809 Mycobacterium tuberculosis gyrA mutations conferring resistance to levofloxacin ARO:3007809 Specific mutations in Mycobacterium tuberculosis gyrB resulting in resistance to levofloxacin. Mtub_gyrB_LEV Rv0005 antibiotic_resistance ARO:3007810 Mycobacterium tuberculosis gyrB mutations conferring resistance to levofloxacin ARO:3007810 Mtub_gyrB_LEV Specific mutations in Mycobacterium tuberculosis fabG1 resulting in resistance to prothionamide. Mtub_fabG1_PTO Rv1483 antibiotic_resistance ARO:3007811 Mycobacterium tuberculosis fabG1 with mutations conferring resistance to prothionamide ARO:3007811 Mtub_fabG1_PTO VIM-75 is a subclass B1 carbapenem-hydrolyzing metallo-beta-lactamase. VIM-75 antibiotic_resistance ARO:3007812 VIM-75 ARO:3007812 VIM-75 VIM-76 is a subclass B1 carbapenem-hydrolyzing metallo-beta-lactamase. VIM-76 antibiotic_resistance ARO:3007813 VIM-76 ARO:3007813 VIM-76 VIM-77 is a subclass B1 carbapenem-hydrolyzing metallo-beta-lactamase. VIM-77 antibiotic_resistance ARO:3007814 VIM-77 ARO:3007814 VIM-77 VIM-78 is a subclass B1 carbapenem-hydrolyzing metallo-beta-lactamase. VIM-78 antibiotic_resistance ARO:3007815 VIM-78 ARO:3007815 VIM-78 VIM-79 is a subclass B1 carbapenem-hydrolyzing metallo-beta-lactamase. VIM-79 antibiotic_resistance ARO:3007816 VIM-79 ARO:3007816 VIM-79 VIM-80 is a subclass B1 carbapenem-hydrolyzing metallo-beta-lactamase. VIM-80 antibiotic_resistance ARO:3007817 VIM-80 ARO:3007817 VIM-80 VIM-81 is a subclass B1 carbapenem-hydrolyzing metallo-beta-lactamase. VIM-81 antibiotic_resistance ARO:3007818 VIM-81 ARO:3007818 VIM-81 VIM-82 is a subclass B1 carbapenem-hydrolyzing metallo-beta-lactamase. VIM-82 antibiotic_resistance ARO:3007819 VIM-82 ARO:3007819 VIM-82 VIM-83 is a subclass B1 carbapenem-hydrolyzing metallo-beta-lactamase. VIM-83 antibiotic_resistance ARO:3007820 VIM-83 ARO:3007820 VIM-83 VIM-84 is a subclass B1 carbapenem-hydrolyzing metallo-beta-lactamase. VIM-84 antibiotic_resistance ARO:3007821 VIM-84 ARO:3007821 VIM-84 VIM-85 is a subclass B1 carbapenem-hydrolyzing metallo-beta-lactamase. VIM-85 antibiotic_resistance ARO:3007822 VIM-85 ARO:3007822 VIM-85 VIM-86 is a subclass B1 carbapenem-hydrolyzing metallo-beta-lactamase. VIM-86 antibiotic_resistance ARO:3007823 VIM-86 ARO:3007823 VIM-86 VIM-87 is a subclass B1 carbapenem-hydrolyzing metallo-beta-lactamase. VIM-87 antibiotic_resistance ARO:3007824 VIM-87 ARO:3007824 VIM-87 GES-47 is a class A carbapenem-hydrolyzing GES-like beta-lactamase. GES-47 antibiotic_resistance ARO:3007825 GES-47 ARO:3007825 GES-47 GES-48 is a class A carbapenem-hydrolyzing GES-like beta-lactamase. GES-48 antibiotic_resistance ARO:3007826 GES-48 ARO:3007826 GES-48 GES_49 is a class A carbapenem-hydrolyzing GES-like beta-lactamase. GES-49 antibiotic_resistance ARO:3007827 GES-49 ARO:3007827 GES-49 GES-50 is a class A carbapenem-hydrolyzing GES-like beta-lactamase. GES-50 antibiotic_resistance ARO:3007828 GES-50 ARO:3007828 GES-50 GES-51 is a class A carbapenem-hydrolyzing GES-like beta-lactamase. GES-51 antibiotic_resistance ARO:3007829 GES-51 ARO:3007829 GES-51 GES-52 is a class A GES-like extended-spectrum beta-lactamase. GES-52 antibiotic_resistance ARO:3007830 GES-52 ARO:3007830 GES-52 GES-53 is a class A carbapenem-hydrolyzing GES-like beta-lactamase. GES-53 antibiotic_resistance ARO:3007831 GES-53 ARO:3007831 GES-53 GES-54 is a class A carbapenem-hydrolyzing GES-like beta-lactamase. GES-54 antibiotic_resistance ARO:3007832 GES-54 ARO:3007832 GES-54 GES is a class A GES-like beta-lactamase. GES-55 antibiotic_resistance ARO:3007833 GES-55 ARO:3007833 GES-55 GES-56 is a class A GES-like beta-lactamase. GES-56 antibiotic_resistance ARO:3007834 GES-56 ARO:3007834 GES-56 GES-57 is a class A GES-like beta-lactamase. GES-57 antibiotic_resistance ARO:3007835 GES-57 ARO:3007835 GES-57 CARB-57 is a class A carbenicillin-hydrolyzing CARB-like beta-lactamase. CARB-57 antibiotic_resistance ARO:3007836 CARB-57 ARO:3007836 CARB-57 CARB-58 is a PSE family class A carbenicillin-hydrolyzing CARB-like beta-lactamase. CARB-58 antibiotic_resistance ARO:3007837 CARB-58 ARO:3007837 CARB-58 tet(65) is a tetracycline efflux gene identified from a Corynebacterium oculi plasmid. tet(65) antibiotic_resistance ARO:3007838 tet(65) ARO:3007838 tet(65) is a tetracycline efflux gene identified from a Corynebacterium oculi plasmid. PMID:38497972 tet(65) CIM (C. indologenes MBL) are a family of subclass B1 metallo-beta-lactamases originally identified from Chryseobacterium indologenes, and which exhibit carbapenem-hydrolyzing activity. antibiotic_resistance ARO:3007839 CIM beta-lactamase ARO:3007839 CIM (C. indologenes MBL) are a family of subclass B1 metallo-beta-lactamases originally identified from Chryseobacterium indologenes, and which exhibit carbapenem-hydrolyzing activity. PMID:38454015 CIM-1 is a CIM-like carbapenem-hydrolyzing metallo-beta-lactamase identified from Chryseobacterium indologenes. CIM-1 antibiotic_resistance ARO:3007840 CIM-1 ARO:3007840 CIM-1 is a CIM-like carbapenem-hydrolyzing metallo-beta-lactamase identified from Chryseobacterium indologenes. PMID:38454015 CIM-1 Antibiotic resistant gene variants of mycobacterial fabG1 which confer resistance to prothionamide antibiotics. antibiotic_resistance ARO:3007841 prothionamide resistant fabG1 ARO:3007841 A historical list of beta-lactamase names, a minority without public sequence data, maintained by Drs. Karen Bush, George Jacoby, and Timothy Palzkill. Since subsumed by curation efforts at the National Center for Biotechnology Information, https://www.ncbi.nlm.nih.gov/bioproject/305729. antibiotic_resistance ARO:3007842 Lahey list of beta-lactamases ARO:3007842 A historical list of beta-lactamase names, a minority without public sequence data, maintained by Drs. Karen Bush, George Jacoby, and Timothy Palzkill. Since subsumed by curation efforts at the National Center for Biotechnology Information, https://www.ncbi.nlm.nih.gov/bioproject/305729. PMID:35380458 PMID:36951174 VRA-F is an ABC transporter ATP-binding protein, or ATP-binding cassette. VRA-F antibiotic_resistance ARO:3007843 VRA-F ARO:3007843 VRA-F is an ABC transporter ATP-binding protein, or ATP-binding cassette. PMID:38838390 VRA-F KPC-135 is a KPC-type class A beta-lactamase. KPC-125 is a variant of KPC-44, differing by a 6 basepair deletion. KPC-135 antibiotic_resistance ARO:3007844 KPC-135 ARO:3007844 KPC-135 is a KPC-type class A beta-lactamase. KPC-125 is a variant of KPC-44, differing by a 6 basepair deletion. PMID:38952349 KPC-135 SIE is a subclass B3 metallo-beta-lactamase with enzymatic activity against cephalosporins and carbapanems, first identified from Sphingobium indicum. antibiotic_resistance ARO:3007845 SIE beta-lactamase ARO:3007845 SIE is a subclass B3 metallo-beta-lactamase with enzymatic activity against cephalosporins and carbapanems, first identified from Sphingobium indicum. PMID:34310207 SIE-1 is SIE beta-lactamase gene family variant. SIE-1 antibiotic_resistance ARO:3007846 SIE-1 ARO:3007846 SIE-1 is SIE beta-lactamase gene family variant. PMID:34310207 SIE-1 NWM is a subclass B3 metallo beta-lactamase with enzymatic activity against carbapenems, first identified in Pseudomonas aeruginosa. antibiotic_resistance ARO:3007847 NWM beta-lactamase ARO:3007847 NWM-1 is a NWM beta-lactamase gene family variant. NWM-1 antibiotic_resistance ARO:3007848 NWM-1 ARO:3007848 NWM-1 Mutations in the F420-dependent glucose-6-phosphate dehydrogenase fgd1 which confer resistance to the nitroimidazole antibiotic delamanid. Mtub_fgd1_DLM Rv0407 antibiotic_resistance ARO:3007849 Mycobacterium tuberculosis fgd1 with mutation conferring resistance to delamanid ARO:3007849 Mutations in the F420-dependent glucose-6-phosphate dehydrogenase fgd1 which confer resistance to the nitroimidazole antibiotic delamanid. ISBN:978-92-4-008241-0 PMID:32361756 Mtub_fgd1_DLM Genetic variants of F420-dependent glucose-6-phosphate dehydrogenase fgd1 with mutations associated with antibiotic resistance. antibiotic_resistance ARO:3007850 antibiotic resistant fgd1 ARO:3007850 Genetic variants of F420-dependent glucose-6-phosphate dehydrogenase Fgd1 with mutations associated with resistance to the nitroimidazole antibiotic delamanid. antibiotic_resistance ARO:3007851 delamanid-resistant fgd1 ARO:3007851 Genetic variants of F420-dependent glucose-6-phosphate dehydrogenase Fgd1 with mutations associated with resistance to the nitroimidazole antibiotic delamanid. PMID:32361756 Genetic variants of the transcription factor Rv0678, which regulates expression of the mmpS5/L5 efflux pump, that are associated with resistance to clofazimine antibiotics. Mtub_Rv0678_CFZ antibiotic_resistance ARO:3007852 Mycobacterium tuberculosis Rv0678 with mutation conferring resistance to clofazimine ARO:3007852 Genetic variants of the transcription factor Rv0678, which regulates expression of the mmpS5/L5 efflux pump, that are associated with resistance to clofazimine antibiotics. ISBN:978-92-4-008241-0 Mtub_Rv0678_CFZ Loss-of-function mutations in the Mycobacterium Rv0678 gene associated with clofazimine resistance. antibiotic_resistance ARO:3007853 clofazimine resistant Rv0678 ARO:3007853 Genetic variants of ATPase subunit C atpE with mutations associated with resistance to bedaquiline antibiotics. Mtub_atpE_BDQ antibiotic_resistance ARO:3007854 Mycobacterium tuberculosis atpE with mutation conferring resistance to bedaquiline ARO:3007854 Genetic variants of ATPase subunit C atpE with mutations associated with resistance to bedaquiline antibiotics. ISBN:978-92-4-008241-0 Mtub_atpE_BDQ CHM is a subclass B1 metallo B-lactamase with enzymatic activity against cephalosporins and carbapenems, first identified in the Chryseobacterium spp. functional gene library. CHM-1 antibiotic_resistance ARO:3007855 CHM-1 ARO:3007855 CHM is a subclass B1 metallo B-lactamase with enzymatic activity against cephalosporins and carbapenems, first identified in the Chryseobacterium spp. functional gene library. PMID:37047008 CHM-1 CHM is a subclass B1 metallo B-lactamase with enzymatic activity against cephalosporins and carbapenems, first identified in the Chryseobacterium spp. functional gene library. antibiotic_resistance ARO:3007856 CHM beta-lactamase ARO:3007856 CHM is a subclass B1 metallo B-lactamase with enzymatic activity against cephalosporins and carbapenems, first identified in the Chryseobacterium spp. functional gene library. PMID:37047008 KPC-134 is an inhibitor-resistant KPC-2 variant which confers resistance to ceftazidime-avibactam. KPC-134 antibiotic_resistance ARO:3007857 KPC-134 ARO:3007857 KPC-134 is an inhibitor-resistant KPC-2 variant which confers resistance to ceftazidime-avibactam. PMID:37772834 KPC-134 BIM is a family of ambler molecular class B beta-lactamases from Pseudomonas putida. It confers resistance to carbapenems and cephalosporins. antibiotic_resistance ARO:3007858 BIM beta-lactamase ARO:3007858 BIM is a family of ambler molecular class B beta-lactamases from Pseudomonas putida. It confers resistance to carbapenems and cephalosporins. PMID:37038995 BIM-1 is an ambler molecular class B beta-lactamase. It confers resistance to carbapenems and cephalosporins. BIM-1 antibiotic_resistance ARO:3007859 BIM-1 ARO:3007859 BIM-1 is an ambler molecular class B beta-lactamase. It confers resistance to carbapenems and cephalosporins. PMID:37038995 BIM-1 DYB is a family of subclass B1 metallo-beta-lactamases identified from Dysgonomonas capnocytophagoides. These enzymes confer resistance to beta-lactam antibiotics, including carbapenems. antibiotic_resistance ARO:3007860 DYB beta-lactamase ARO:3007860 DYB is a family of subclass B1 metallo-beta-lactamases identified from Dysgonomonas capnocytophagoides. These enzymes confer resistance to beta-lactam antibiotics, including carbapenems. PMID:39009111 DYB-1 is a subclass B1 metallo-beta-lactamases identified from Dysgonomonas capnocytophagoides. DYB-1 is associated with resistance to meropenem and ceftazidime. DYB-1 antibiotic_resistance ARO:3007861 DYB-1 ARO:3007861 DYB-1 is a subclass B1 metallo-beta-lactamases identified from Dysgonomonas capnocytophagoides. DYB-1 is associated with resistance to meropenem and ceftazidime. PMID:39009111 DYB-1 Simplified Molecular Input Line Entry System (SMILES), a chemical structure line notation (a typographical method using printable characters) for entering and representing molecules (description copied from PubChem). Canonical SMILES in CARD are acquired from ChEMBL. antibiotic_resistance ARO:3007862 Canonical SMILES ARO:3007862 ASU1 is a family of class A beta-lactamase enzymes shown to confer resistance to beta-lactam and cephalosporin antibiotics through enzymatic inactivation. antibiotic_resistance ARO:3007863 ASU1 beta-lactamase ARO:3007863 ASU1 is a family of class A beta-lactamase enzymes shown to confer resistance to beta-lactam and cephalosporin antibiotics through enzymatic inactivation. PMID:36626997 B3SU1 is a family of subclass B3 metallo-beta-lactamase enzymes which confer resistance to beta-lactam and cephalosporin antibiotics through enzymatic inactivation. antibiotic_resistance ARO:3007864 B3SU1 beta-lactamase ARO:3007864 B3SU1 is a family of subclass B3 metallo-beta-lactamase enzymes which confer resistance to beta-lactam and cephalosporin antibiotics through enzymatic inactivation. PMID:36626997 B3SU2 is a family of subclass B3 metallo-beta-lactamases which confer resistance to beta-lactam and cephalosporin antibiotics through enzymatic inactivation. antibiotic_resistance ARO:3007865 B3SU2 beta-lactamase ARO:3007865 B3SU2 is a family of subclass B3 metallo-beta-lactamases which confer resistance to beta-lactam and cephalosporin antibiotics through enzymatic inactivation. PMID:36626997 BMHC is a family of subclass B1 metallo-beta-lactamase enzymes which confer resistance to carbapenem antibiotics through enzymatic inactivation. antibiotic_resistance ARO:3007866 BMHC beta-lactamase ARO:3007866 BOR is a family of class A beta-lactamase enzymes which confer resistance to beta-lactam antibiotics through enzymatic inactivation. antibiotic_resistance ARO:3007867 BOR beta-lactamase ARO:3007867 BOR is a family of class A beta-lactamase enzymes which confer resistance to beta-lactam antibiotics through enzymatic inactivation. PMID:15917575 GMA is a family of class A beta-lactamases which confer resistance to beta-lactam antibiotics through enzymatic inactivation. antibiotic_resistance ARO:3007868 GMA beta-lactamase ARO:3007868 HBL is a family of class A beta-lactamases which enzymatically inactivate beta-lactam antibiotics. antibiotic_resistance ARO:3007869 HBL beta-lactamase ARO:3007869 HER is a family of class A beta-lactamases which enzymatically inactivation penam-type beta-lactam antibiotics. antibiotic_resistance ARO:3007870 HER beta-lactamase ARO:3007870 HER is a family of class A beta-lactamases which enzymatically inactivation penam-type beta-lactam antibiotics. PMID:12878539 MUN is a family of extended-spectrum class A beta-lactamases which enzymatic inactivate beta-lactam and cephalosporin antibiotics. antibiotic_resistance ARO:3007871 MUN beta-lactamase ARO:3007871 PAD is a family of carbapenem-hydrolyzing class A beta-lactamases which enzymatically inactivate beta-lactam and carbapenem antibiotics. antibiotic_resistance ARO:3007872 PAD beta-lactamase ARO:3007872 PAD is a family of carbapenem-hydrolyzing class A beta-lactamases which enzymatically inactivate beta-lactam and carbapenem antibiotics. PMID:28827656 PEN-A is a family of class A beta-lactamases which enzymatically inactivate beta-lactam antibiotics. antibiotic_resistance ARO:3007873 PEN-A beta-lactamase ARO:3007873 PEN-B is a family of class A beta-lactamase enzymes which inactivate beta-lactam antibiotics. antibiotic_resistance ARO:3007874 PEN-B beta-lactamase ARO:3007874 PEN-B is a family of class A beta-lactamase enzymes which inactivate beta-lactam antibiotics. PMID:19075063 PNC is a family of extended-spectrum class C beta-lactamases which enzymatically inactivate cephalosporin antibiotics. antibiotic_resistance ARO:3007875 PNC beta-lactamase ARO:3007875 RAA is a family of class A extended-spectrum beta-lactamases which enzymatically inactivate cephalosporin antibiotics. antibiotic_resistance ARO:3007876 RAA beta-lactamase ARO:3007876 RASA is a family of extended-spectrum class A beta-lactamases which enzymatically inactivate cephalosporin antibiotics. antibiotic_resistance ARO:3007877 RASA beta-lactamase ARO:3007877 RSC1 is a family of class C beta-lactamases which inactivate cephalosporin antibiotics. antibiotic_resistance ARO:3007878 RSC1 beta-lactamase ARO:3007878 RSC1 is a family of class C beta-lactamases which inactivate cephalosporin antibiotics. PMID:29316517 RSD1 is a family of class D beta-lactamases which confer resistance to beta-lactam antibiotics. antibiotic_resistance ARO:3007879 RSD1 ARO:3007879 RSD1 is a family of class D beta-lactamases which confer resistance to beta-lactam antibiotics. PMID:29316517 SED is a family of broad-spectrum class A beta-lactamases. antibiotic_resistance ARO:3007880 SED beta-lactamase ARO:3007880 SED is a family of broad-spectrum class A beta-lactamases. PMID:11451687 SFDC is a family of extended-spectrum class C beta-lactamases which confer resistance to cephalosporin antibiotics. antibiotic_resistance ARO:3007881 SFDC beta-lactamase ARO:3007881 SFDC is a family of extended-spectrum class C beta-lactamases which confer resistance to cephalosporin antibiotics. PMID:34227210 YOC is a family of class C beta-lactamases which inactivate cephalosporin antibiotics. antibiotic_resistance ARO:3007882 YOC beta-lactamase ARO:3007882 Cephalosporin-hydrolyzing class C beta-lactamase ACT-100. ACT-100 antibiotic_resistance ARO:3007883 ACT-100 ARO:3007883 ACT-100 Cephalosporin-hydrolyzing class C beta-lactamase ACT-101. ACT-101 antibiotic_resistance ARO:3007884 ACT-101 ARO:3007884 ACT-101 Cephalosporin-hydrolyzing class C beta-lactamase ACT-102. ACT-102 antibiotic_resistance ARO:3007885 ACT-102 ARO:3007885 ACT-102 Cephalosporin-hydrolyzing class C beta-lactamase ACT-103. ACT-103 antibiotic_resistance ARO:3007886 ACT-103 ARO:3007886 ACT-103 Cephalosporin-hydrolyzing class C beta-lactamase ACT-104. ACT-104 antibiotic_resistance ARO:3007887 ACT-104 ARO:3007887 ACT-104 Cephalosporin-hydrolyzing class C beta-lactamase ACT-105. ACT-105 antibiotic_resistance ARO:3007888 ACT-105 ARO:3007888 ACT-105 Cephalosporin-hydrolyzing class C beta-lactamase ACT-106. ACT-106 antibiotic_resistance ARO:3007889 ACT-106 ARO:3007889 ACT-106 Cephalosporin-hydrolyzing class C beta-lactamase ACT-107. ACT-107 antibiotic_resistance ARO:3007890 ACT-107 ARO:3007890 ACT-107 Cephalosporin-hydrolyzing class C beta-lactamase ACT-108. ACT-108 antibiotic_resistance ARO:3007891 ACT-108 ARO:3007891 ACT-108 Cephalosporin-hydrolyzing class C beta-lactamase ACT-109. ACT-109 antibiotic_resistance ARO:3007892 ACT-109 ARO:3007892 ACT-109 Cephalosporin-hydrolyzing class C beta-lactamase ACT-110. ACT-110 antibiotic_resistance ARO:3007893 ACT-110 ARO:3007893 ACT-110 Cephalosporin-hydrolyzing class C beta-lactamase ACT-111. ACT-111 antibiotic_resistance ARO:3007894 ACT-111 ARO:3007894 ACT-111 Cephalosporin-hydrolyzing class C beta-lactamase ACT-112. ACT-112 antibiotic_resistance ARO:3007895 ACT-112 ARO:3007895 ACT-112 Cephalosporin-hydrolyzing class C beta-lactamase ACT-113. ACT-113 antibiotic_resistance ARO:3007896 ACT-113 ARO:3007896 ACT-113 Cephalosporin-hydrolyzing class C beta-lactamase ACT-115. ACT-115 antibiotic_resistance ARO:3007897 ACT-115 ARO:3007897 ACT-115 Cephalosporin-hydrolyzing class C beta-lactamase ACT-116. ACT-116 antibiotic_resistance ARO:3007898 ACT-116 ARO:3007898 ACT-116 Cephalosporin-hydrolyzing class C beta-lactamase ACT-117. ACT-117 antibiotic_resistance ARO:3007899 ACT-117 ARO:3007899 ACT-117 Cephalosporin-hydrolyzing class C beta-lactamase ACT-118. ACT-118 antibiotic_resistance ARO:3007900 ACT-118 ARO:3007900 ACT-118 Cephalosporin-hydrolyzing class C beta-lactamase ACT-119. ACT-119 antibiotic_resistance ARO:3007901 ACT-119 ARO:3007901 ACT-119 Cephalosporin-hydrolyzing class C beta-lactamase ACT-120. ACT-120 antibiotic_resistance ARO:3007902 ACT-120 ARO:3007902 ACT-120 Cephalosporin-hydrolyzing class C beta-lactamase ACT-121. ACT-121 antibiotic_resistance ARO:3007903 ACT-121 ARO:3007903 ACT-121 Cephalosporin-hydrolyzing class C beta-lactamase ACT-122. ACT-122 antibiotic_resistance ARO:3007904 ACT-122 ARO:3007904 ACT-122 Cephalosporin-hydrolyzing class C beta-lactamase ACT-123. ACT-123 antibiotic_resistance ARO:3007905 ACT-123 ARO:3007905 ACT-123 Cephalosporin-hydrolyzing class C beta-lactamase ACT-124. ACT-124 antibiotic_resistance ARO:3007906 ACT-124 ARO:3007906 ACT-124 Cephalosporin-hydrolyzing class C beta-lactamase ACT-131. ACT-131 antibiotic_resistance ARO:3007907 ACT-131 ARO:3007907 ACT-131 Cephalosporin-hydrolyzing class C beta-lactamase ACT-140. ACT-140 antibiotic_resistance ARO:3007908 ACT-140 ARO:3007908 ACT-140 Cephalosporin-hydrolyzing class C beta-lactamase ACT-141. ACT-141 antibiotic_resistance ARO:3007909 ACT-141 ARO:3007909 ACT-141 Cephalosporin-hydrolyzing class C beta-lactamase ACT-142. ACT-142 antibiotic_resistance ARO:3007910 ACT-142 ARO:3007910 ACT-142 Cephalosporin-hydrolyzing class C beta-lactamase ACT-143. ACT-143 antibiotic_resistance ARO:3007911 ACT-143 ARO:3007911 ACT-143 Cephalosporin-hydrolyzing class C beta-lactamase ACT-144. ACT-144 antibiotic_resistance ARO:3007912 ACT-144 ARO:3007912 ACT-144 Cephalosporin-hydrolyzing class C beta-lactamase ACT-145. ACT-145 antibiotic_resistance ARO:3007913 ACT-145 ARO:3007913 ACT-145 Cephalosporin-hydrolyzing class C beta-lactamase ACT-146. ACT-146 antibiotic_resistance ARO:3007914 ACT-146 ARO:3007914 ACT-146 Cephalosporin-hydrolyzing class C beta-lactamase ACT-148. ACT-148 antibiotic_resistance ARO:3007915 ACT-148 ARO:3007915 ACT-148 Cephalosporin-hydrolyzing class C beta-lactamase ACT-150. ACT-150 antibiotic_resistance ARO:3007916 ACT-150 ARO:3007916 ACT-150 Cephalosporin-hydrolyzing class C beta-lactamase ACT-151. ACT-151 antibiotic_resistance ARO:3007917 ACT-151 ARO:3007917 ACT-151 Cephalosporin-hydrolyzing class C beta-lactamase ACT-153. ACT-153 antibiotic_resistance ARO:3007918 ACT-153 ARO:3007918 ACT-153 Cephalosporin-hydrolyzing class C beta-lactamase ACT-154. ACT-154 antibiotic_resistance ARO:3007919 ACT-154 ARO:3007919 ACT-154 Cephalosporin-hydrolyzing class C beta-lactamase ACT-155. ACT-155 antibiotic_resistance ARO:3007920 ACT-155 ARO:3007920 ACT-155 Cephalosporin-hydrolyzing class C beta-lactamase ACT-156. ACT-156 antibiotic_resistance ARO:3007921 ACT-156 ARO:3007921 ACT-156 Cephalosporin-hydrolyzing class C beta-lactamase ACT-157. ACT-157 antibiotic_resistance ARO:3007922 ACT-157 ARO:3007922 ACT-157 Cephalosporin-hydrolyzing class C beta-lactamase ACT-158. ACT-158 antibiotic_resistance ARO:3007923 ACT-158 ARO:3007923 ACT-158 Cephalosporin-hydrolyzing class C beta-lactamase ACT-159. ACT-159 antibiotic_resistance ARO:3007924 ACT-159 ARO:3007924 ACT-159 Cephalosporin-hydrolyzing class C beta-lactamase ACT-160. ACT-160 antibiotic_resistance ARO:3007925 ACT-160 ARO:3007925 ACT-160 Cephalosporin-hydrolyzing class C beta-lactamase ACT-161. ACT-161 antibiotic_resistance ARO:3007926 ACT-161 ARO:3007926 ACT-161 Cephalosporin-hydrolyzing class C beta-lactamase ACT-162. ACT-162 antibiotic_resistance ARO:3007927 ACT-162 ARO:3007927 ACT-162 Cephalosporin-hydrolyzing class C beta-lactamase ACT-165. ACT-165 antibiotic_resistance ARO:3007928 ACT-165 ARO:3007928 ACT-165 Cephalosporin-hydrolyzing class C beta-lactamase ACT-166. ACT-166 antibiotic_resistance ARO:3007929 ACT-166 ARO:3007929 ACT-166 Cephalosporin-hydrolyzing class C beta-lactamase ACT-167. ACT-167 antibiotic_resistance ARO:3007930 ACT-167 ARO:3007930 ACT-167 Cephalosporin-hydrolyzing class C beta-lactamase ACT-168. ACT-168 antibiotic_resistance ARO:3007931 ACT-168 ARO:3007931 ACT-168 Cephalosporin-hydrolyzing class C beta-lactamase ACT-169. ACT-169 antibiotic_resistance ARO:3007932 ACT-169 ARO:3007932 ACT-169 Cephalosporin-hydrolyzing class C beta-lactamase ACT-170. ACT-170 antibiotic_resistance ARO:3007933 ACT-170 ARO:3007933 ACT-170 Cephalosporin-hydrolyzing class C beta-lactamase ACT-171. ACT-171 antibiotic_resistance ARO:3007934 ACT-171 ARO:3007934 ACT-171 Cephalosporin-hydrolyzing class C beta-lactamase ACT-172. ACT-172 antibiotic_resistance ARO:3007935 ACT-172 ARO:3007935 ACT-172 Cephalosporin-hydrolyzing class C beta-lactamase ACT-173. ACT-173 antibiotic_resistance ARO:3007936 ACT-173 ARO:3007936 ACT-173 Cephalosporin-hydrolyzing class C beta-lactamase ACT-174. ACT-174 antibiotic_resistance ARO:3007937 ACT-174 ARO:3007937 ACT-174 Cephalosporin-hydrolyzing class C beta-lactamase ACT-175. ACT-175 antibiotic_resistance ARO:3007938 ACT-175 ARO:3007938 ACT-175 Cephalosporin-hydrolyzing class C beta-lactamase ACT-176. ACT-176 antibiotic_resistance ARO:3007939 ACT-176 ARO:3007939 ACT-176 Cephalosporin-hydrolyzing class C beta-lactamase ACT-177. ACT-177 antibiotic_resistance ARO:3007940 ACT-177 ARO:3007940 ACT-177 Cephalosporin-hydrolyzing class C beta-lactamase ACT-178. ACT-178 antibiotic_resistance ARO:3007941 ACT-178 ARO:3007941 ACT-178 Cephalosporin-hydrolyzing class C beta-lactamase ACT-179. ACT-179 antibiotic_resistance ARO:3007942 ACT-179 ARO:3007942 ACT-179 Cephalosporin-hydrolyzing class C beta-lactamase ACT-180. ACT-180 antibiotic_resistance ARO:3007943 ACT-180 ARO:3007943 ACT-180 Cephalosporin-hydrolyzing class C beta-lactamase ACT-181. ACT-181 antibiotic_resistance ARO:3007944 ACT-181 ARO:3007944 ACT-181 Cephalosporin-hydrolyzing class C beta-lactamase ACT-182. ACT-182 antibiotic_resistance ARO:3007945 ACT-182 ARO:3007945 ACT-182 Cephalosporin-hydrolyzing class C beta-lactamase ACT-183. ACT-183 antibiotic_resistance ARO:3007946 ACT-183 ARO:3007946 ACT-183 Cephalosporin-hydrolyzing class C beta-lactamase ACT-184. ACT-184 antibiotic_resistance ARO:3007947 ACT-184 ARO:3007947 ACT-184 Cephalosporin-hydrolyzing class C beta-lactamase ACT-185. ACT-185 antibiotic_resistance ARO:3007948 ACT-185 ARO:3007948 ACT-185 Cephalosporin-hydrolyzing class C beta-lactamase ACT-186. ACT-186 antibiotic_resistance ARO:3007949 ACT-186 ARO:3007949 ACT-186 Cephalosporin-hydrolyzing class C beta-lactamase ACT-187. ACT-187 antibiotic_resistance ARO:3007950 ACT-187 ARO:3007950 ACT-187 Cephalosporin-hydrolyzing class C beta-lactamase ACT-188. ACT-188 antibiotic_resistance ARO:3007951 ACT-188 ARO:3007951 ACT-188 Cephalosporin-hydrolyzing class C beta-lactamase ACT-189. ACT-189 antibiotic_resistance ARO:3007952 ACT-189 ARO:3007952 ACT-189 Cephalosporin-hydrolyzing class C beta-lactamase ACT-190. ACT-190 antibiotic_resistance ARO:3007953 ACT-190 ARO:3007953 ACT-190 Cephalosporin-hydrolyzing class C beta-lactamase ACT-191. ACT-191 antibiotic_resistance ARO:3007954 ACT-191 ARO:3007954 ACT-191 Cephalosporin-hydrolyzing class C beta-lactamase ACT-192. ACT-192 antibiotic_resistance ARO:3007955 ACT-192 ARO:3007955 ACT-192 Cephalosporin-hydrolyzing class C beta-lactamase ACT-193. ACT-193 antibiotic_resistance ARO:3007956 ACT-193 ARO:3007956 ACT-193 Cephalosporin-hydrolyzing class C beta-lactamase ACT-194. ACT-194 antibiotic_resistance ARO:3007957 ACT-194 ARO:3007957 ACT-194 Ceftazidime-hydrolyzing class C beta-lactamase ACT-85. ACT-85 antibiotic_resistance ARO:3007958 ACT-85 ARO:3007958 ACT-85 Ceftazidime-hydrolyzing class C beta-lactamase ACT-86. ACT-86 antibiotic_resistance ARO:3007959 ACT-86 ARO:3007959 ACT-86 Cephalosporin-hydrolyzing class C beta-lactamase ACT-88. ACT-88 antibiotic_resistance ARO:3007960 ACT-88 ARO:3007960 ACT-88 Cephalosporin-hydrolyzing class C beta-lactamase ACT-89. ACT-89 antibiotic_resistance ARO:3007961 ACT-89 ARO:3007961 ACT-89 Cephalosporin-hydrolyzing class C beta-lactamase ACT-90. ACT-90 antibiotic_resistance ARO:3007962 ACT-90 ARO:3007962 ACT-90 Cephalosporin-hydrolyzing class C beta-lactamase ACT-91. ACT-91 antibiotic_resistance ARO:3007963 ACT-91 ARO:3007963 ACT-91 Cephalosporin-hydrolyzing class C beta-lactamase ACT-92. ACT-92 antibiotic_resistance ARO:3007964 ACT-92 ARO:3007964 ACT-92 Cephalosporin-hydrolyzing class C beta-lactamase ACT-93. ACT-93 antibiotic_resistance ARO:3007965 ACT-93 ARO:3007965 ACT-93 Cephalosporin-hydrolyzing class C beta-lactamase ACT-94. ACT-94 antibiotic_resistance ARO:3007966 ACT-94 ARO:3007966 ACT-94 Cephalosporin-hydrolyzing class C beta-lactamase ACT-95. ACT-95 antibiotic_resistance ARO:3007967 ACT-95 ARO:3007967 ACT-95 Cephalosporin-hydrolyzing class C beta-lactamase ACT-96. ACT-96 antibiotic_resistance ARO:3007968 ACT-96 ARO:3007968 ACT-96 Cephalosporin-hydrolyzing class C beta-lactamase ACT-97. ACT-97 antibiotic_resistance ARO:3007969 ACT-97 ARO:3007969 ACT-97 Cephalosporin-hydrolyzing class C beta-lactamase ACT-98. ACT-98 antibiotic_resistance ARO:3007970 ACT-98 ARO:3007970 ACT-98 Cephalosporin-hydrolyzing class C beta-lactamase ACT-99. ACT-99 antibiotic_resistance ARO:3007971 ACT-99 ARO:3007971 ACT-99 Extended spectrum class C beta-lactamase ACT-GC1. ACT-GC1 antibiotic_resistance ARO:3007972 ACT-GC1 ARO:3007972 ACT-GC1 Extended-spectrum class C beta-lactamase ADC-257. ADC-257 antibiotic_resistance ARO:3007973 ADC-257 ARO:3007973 ADC-257 Extended-spectrum class C beta-lactamase ADC-258. ADC-258 antibiotic_resistance ARO:3007974 ADC-258 ARO:3007974 ADC-258 Extended-spectrum class C beta-lactamase ADC-259. ADC-259 antibiotic_resistance ARO:3007975 ADC-259 ARO:3007975 ADC-259 Extended-spectrum class C beta-lactamase ADC-260. ADC-260 antibiotic_resistance ARO:3007976 ADC-260 ARO:3007976 ADC-260 Cefepime-hydrolyzing class C beta-lactamase ADC-261. ADC-261 antibiotic_resistance ARO:3007977 ADC-261 ARO:3007977 ADC-261 Extended-spectrum class C beta-lactamase ADC-262. ADC-262 antibiotic_resistance ARO:3007978 ADC-262 ARO:3007978 ADC-262 Extended-spectrum class C beta-lactamase ADC-263. ADC-263 antibiotic_resistance ARO:3007979 ADC-263 ARO:3007979 ADC-263 Extended-spectrum class C beta-lactamase ADC-264. ADC-264 antibiotic_resistance ARO:3007980 ADC-264 ARO:3007980 ADC-264 Extended-spectrum class C beta-lactamase ADC-265. ADC-265 antibiotic_resistance ARO:3007981 ADC-265 ARO:3007981 ADC-265 Extended-spectrum class C beta-lactamase ADC-266. ADC-266 antibiotic_resistance ARO:3007982 ADC-266 ARO:3007982 ADC-266 Extended-spectrum class C beta-lactamase ADC-267. ADC-267 antibiotic_resistance ARO:3007983 ADC-267 ARO:3007983 ADC-267 Extended-spectrum class C beta-lactamase ADC-268. ADC-268 antibiotic_resistance ARO:3007984 ADC-268 ARO:3007984 ADC-268 Extended-spectrum class C beta-lactamase ADC-269. ADC-269 antibiotic_resistance ARO:3007985 ADC-269 ARO:3007985 ADC-269 Extended-spectrum class C beta-lactamase ADC-270. ADC-270 antibiotic_resistance ARO:3007986 ADC-270 ARO:3007986 ADC-270 Extended-spectrum class C beta-lactamase ADC-271. ADC-271 antibiotic_resistance ARO:3007987 ADC-271 ARO:3007987 ADC-271 Extended-spectrum class C beta-lactamase ADC-272. ADC-272 antibiotic_resistance ARO:3007988 ADC-272 ARO:3007988 ADC-272 Extended-spectrum class C beta-lactamase ADC-273. ADC-273 antibiotic_resistance ARO:3007989 ADC-273 ARO:3007989 ADC-273 Extended-spectrum class C beta-lactamase ADC-274. ADC-274 antibiotic_resistance ARO:3007990 ADC-274 ARO:3007990 ADC-274 Extended-spectrum class C beta-lactamase ADC-275. ADC-275 antibiotic_resistance ARO:3007991 ADC-275 ARO:3007991 ADC-275 Extended-spectrum class C beta-lactamase ADC-276. ADC-276 antibiotic_resistance ARO:3007992 ADC-276 ARO:3007992 ADC-276 Extended-spectrum class C beta-lactamase ADC-277. ADC-277 antibiotic_resistance ARO:3007993 ADC-277 ARO:3007993 ADC-277 Extended-spectrum class C beta-lactamase ADC-278. ADC-278 antibiotic_resistance ARO:3007994 ADC-278 ARO:3007994 ADC-278 Extended-spectrum class C beta-lactamase ADC-279. ADC-279 antibiotic_resistance ARO:3007995 ADC-279 ARO:3007995 ADC-279 Extended-spectrum class C beta-lactamase ADC-280. ADC-280 antibiotic_resistance ARO:3007996 ADC-280 ARO:3007996 ADC-280 Extended-spectrum class C beta-lactamase ADC-281. ADC-281 antibiotic_resistance ARO:3007997 ADC-281 ARO:3007997 ADC-281 Extended-spectrum class C beta-lactamase ADC-282. ADC-282 antibiotic_resistance ARO:3007998 ADC-282 ARO:3007998 ADC-282 Extended-spectrum class C beta-lactamase ADC-283. ADC-283 antibiotic_resistance ARO:3007999 ADC-283 ARO:3007999 ADC-283 Extended-spectrum class C beta-lactamase ADC-284. ADC-284 antibiotic_resistance ARO:3008000 ADC-284 ARO:3008000 ADC-284 Extended-spectrum class C beta-lactamase ADC-285. ADC-285 antibiotic_resistance ARO:3008001 ADC-285 ARO:3008001 ADC-285 Extended-spectrum class C beta-lactamase ADC-286. ADC-286 antibiotic_resistance ARO:3008002 ADC-286 ARO:3008002 ADC-286 Extended-spectrum class C beta-lactamase ADC-287. ADC-287 antibiotic_resistance ARO:3008003 ADC-287 ARO:3008003 ADC-287 Extended-spectrum class C beta-lactamase ADC-288. ADC-288 antibiotic_resistance ARO:3008004 ADC-288 ARO:3008004 ADC-288 Extended-spectrum class C beta-lactamase ADC-289. ADC-289 antibiotic_resistance ARO:3008005 ADC-289 ARO:3008005 ADC-289 Extended-spectrum class C beta-lactamase ADC-290. ADC-290 antibiotic_resistance ARO:3008006 ADC-290 ARO:3008006 ADC-290 Extended-spectrum class C beta-lactamase ADC-291. ADC-291 antibiotic_resistance ARO:3008007 ADC-291 ARO:3008007 ADC-291 Extended-spectrum class C beta-lactamase ADC-292. ADC-292 antibiotic_resistance ARO:3008008 ADC-292 ARO:3008008 ADC-292 Extended-spectrum class C beta-lactamase ADC-293. ADC-293 antibiotic_resistance ARO:3008009 ADC-293 ARO:3008009 ADC-293 Extended-spectrum class C beta-lactamase ADC-294. ADC-294 antibiotic_resistance ARO:3008010 ADC-294 ARO:3008010 ADC-294 Extended-spectrum class C beta-lactamase ADC-295. ADC-295 antibiotic_resistance ARO:3008011 ADC-295 ARO:3008011 ADC-295 Extended-spectrum class C beta-lactamase ADC-302. ADC-302 antibiotic_resistance ARO:3008012 ADC-302 ARO:3008012 ADC-302 Extended-spectrum class C beta-lactamase ADC-303. ADC-303 antibiotic_resistance ARO:3008013 ADC-303 ARO:3008013 ADC-303 Extended-spectrum class C beta-lactamase ADC-304. ADC-304 antibiotic_resistance ARO:3008014 ADC-304 ARO:3008014 ADC-304 Extended-spectrum class C beta-lactamase ADC-305. ADC-305 antibiotic_resistance ARO:3008015 ADC-305 ARO:3008015 ADC-305 Extended-spectrum class C beta-lactamase ADC-306. ADC-306 antibiotic_resistance ARO:3008016 ADC-306 ARO:3008016 ADC-306 Extended-spectrum class C beta-lactamase ADC-307. ADC-307 antibiotic_resistance ARO:3008017 ADC-307 ARO:3008017 ADC-307 Extended-spectrum class C beta-lactamase ADC-308. ADC-308 antibiotic_resistance ARO:3008018 ADC-308 ARO:3008018 ADC-308 Extended-spectrum class C beta-lactamase ADC-309. ADC-309 antibiotic_resistance ARO:3008019 ADC-309 ARO:3008019 ADC-309 Extended-spectrum class C beta-lactamase ADC-310. ADC-310 antibiotic_resistance ARO:3008020 ADC-310 ARO:3008020 ADC-310 Extended-spectrum class C beta-lactamase ADC-311. ADC-311 antibiotic_resistance ARO:3008021 ADC-311 ARO:3008021 ADC-311 Extended-spectrum class C beta-lactamase ADC-312. ADC-312 antibiotic_resistance ARO:3008022 ADC-312 ARO:3008022 ADC-312 Extended-spectrum class C beta-lactamase ADC-313. ADC-313 antibiotic_resistance ARO:3008023 ADC-313 ARO:3008023 ADC-313 Extended-spectrum class C beta-lactamase ADC-314. ADC-314 antibiotic_resistance ARO:3008024 ADC-314 ARO:3008024 ADC-314 Extended-spectrum class C beta-lactamase ADC-315. ADC-315 antibiotic_resistance ARO:3008025 ADC-315 ARO:3008025 ADC-315 Extended-spectrum class C beta-lactamase ADC-316. ADC-316 antibiotic_resistance ARO:3008026 ADC-316 ARO:3008026 ADC-316 Extended-spectrum class C beta-lactamase ADC-317. ADC-317 antibiotic_resistance ARO:3008027 ADC-317 ARO:3008027 ADC-317 Extended-spectrum class C beta-lactamase ADC-318. ADC-318 antibiotic_resistance ARO:3008028 ADC-318 ARO:3008028 ADC-318 Extended-spectrum class C beta-lactamase ADC-319. ADC-319 antibiotic_resistance ARO:3008029 ADC-319 ARO:3008029 ADC-319 Extended-spectrum class C beta-lactamase ADC-320. ADC-320 antibiotic_resistance ARO:3008030 ADC-320 ARO:3008030 ADC-320 Extended-spectrum class C beta-lactamase ADC-321. ADC-321 antibiotic_resistance ARO:3008031 ADC-321 ARO:3008031 ADC-321 Extended-spectrum class C beta-lactamase ADC-322. ADC-322 antibiotic_resistance ARO:3008032 ADC-322 ARO:3008032 ADC-322 Extended-spectrum class C beta-lactamase ADC-323. ADC-323 antibiotic_resistance ARO:3008033 ADC-323 ARO:3008033 ADC-323 Extended-spectrum class C beta-lactamase ADC-324. ADC-324 antibiotic_resistance ARO:3008034 ADC-324 ARO:3008034 ADC-324 Extended-spectrum class C beta-lactamase ADC-325. ADC-325 antibiotic_resistance ARO:3008035 ADC-325 ARO:3008035 ADC-325 Extended-spectrum class C beta-lactamase ADC-326. ADC-326 antibiotic_resistance ARO:3008036 ADC-326 ARO:3008036 ADC-326 Extended-spectrum class C beta-lactamase ADC-327. ADC-327 antibiotic_resistance ARO:3008037 ADC-327 ARO:3008037 ADC-327 Extended-spectrum class C beta-lactamase ADC-328. ADC-328 antibiotic_resistance ARO:3008038 ADC-328 ARO:3008038 ADC-328 Extended-spectrum class C beta-lactamase ADC-329. ADC-329 antibiotic_resistance ARO:3008039 ADC-329 ARO:3008039 ADC-329 Extended-spectrum class C beta-lactamase ADC-330. ADC-330 antibiotic_resistance ARO:3008040 ADC-330 ARO:3008040 ADC-330 Extended-spectrum class C beta-lactamase ADC-331. ADC-331 antibiotic_resistance ARO:3008041 ADC-331 ARO:3008041 ADC-331 Extended-spectrum class C beta-lactamase ADC-332. ADC-332 antibiotic_resistance ARO:3008042 ADC-332 ARO:3008042 ADC-332 Extended-spectrum class C beta-lactamase ADC-333. ADC-333 antibiotic_resistance ARO:3008043 ADC-333 ARO:3008043 ADC-333 Extended-spectrum class C beta-lactamase ADC-334. ADC-334 antibiotic_resistance ARO:3008044 ADC-334 ARO:3008044 ADC-334 Extended-spectrum class C beta-lactamase ADC-335. ADC-335 antibiotic_resistance ARO:3008045 ADC-335 ARO:3008045 ADC-335 Extended-spectrum class C beta-lactamase ADC-336. ADC-336 antibiotic_resistance ARO:3008046 ADC-336 ARO:3008046 ADC-336 Extended-spectrum class C beta-lactamase ADC-337. ADC-337 antibiotic_resistance ARO:3008047 ADC-337 ARO:3008047 ADC-337 Extended-spectrum class C beta-lactamase ADC-338. ADC-338 antibiotic_resistance ARO:3008048 ADC-338 ARO:3008048 ADC-338 Extended-spectrum class C beta-lactamase ADC-339. ADC-339 antibiotic_resistance ARO:3008049 ADC-339 ARO:3008049 ADC-339 Extended-spectrum class C beta-lactamase ADC-340. ADC-340 antibiotic_resistance ARO:3008050 ADC-340 ARO:3008050 ADC-340 Extended-spectrum class C beta-lactamase ADC-341. ADC-341 antibiotic_resistance ARO:3008051 ADC-341 ARO:3008051 ADC-341 Extended-spectrum class C beta-lactamase ADC-342. ADC-342 antibiotic_resistance ARO:3008052 ADC-342 ARO:3008052 ADC-342 Extended-spectrum class C beta-lactamase ADC-343. ADC-343 antibiotic_resistance ARO:3008053 ADC-343 ARO:3008053 ADC-343 Extended-spectrum class C beta-lactamase ADC-344. ADC-344 antibiotic_resistance ARO:3008054 ADC-344 ARO:3008054 ADC-344 Extended-spectrum class C beta-lactamase ADC-345. ADC-345 antibiotic_resistance ARO:3008055 ADC-345 ARO:3008055 ADC-345 Extended-spectrum class C beta-lactamase ADC-346. ADC-346 antibiotic_resistance ARO:3008056 ADC-346 ARO:3008056 ADC-346 Extended-spectrum class C beta-lactamase ADC-347. ADC-347 antibiotic_resistance ARO:3008057 ADC-347 ARO:3008057 ADC-347 Extended-spectrum class C beta-lactamase ADC-348. ADC-348 antibiotic_resistance ARO:3008058 ADC-348 ARO:3008058 ADC-348 Extended-spectrum class C beta-lactamase ADC-349. ADC-349 antibiotic_resistance ARO:3008059 ADC-349 ARO:3008059 ADC-349 Extended-spectrum class C beta-lactamase ADC-350. ADC-350 antibiotic_resistance ARO:3008060 ADC-350 ARO:3008060 ADC-350 Extended-spectrum class C beta-lactamase ADC-351. ADC-351 antibiotic_resistance ARO:3008061 ADC-351 ARO:3008061 ADC-351 Extended-spectrum class C beta-lactamase ADC-352. ADC-352 antibiotic_resistance ARO:3008062 ADC-352 ARO:3008062 ADC-352 Extended-spectrum class C beta-lactamase ADC-353. ADC-353 antibiotic_resistance ARO:3008063 ADC-353 ARO:3008063 ADC-353 Extended-spectrum class C beta-lactamase ADC-354. ADC-354 antibiotic_resistance ARO:3008064 ADC-354 ARO:3008064 ADC-354 Extended-spectrum class C beta-lactamase ADC-355. ADC-355 antibiotic_resistance ARO:3008065 ADC-355 ARO:3008065 ADC-355 Extended-spectrum class C beta-lactamase ADC-356. ADC-356 antibiotic_resistance ARO:3008066 ADC-356 ARO:3008066 ADC-356 Extended-spectrum class C beta-lactamase ADC-357. ADC-357 antibiotic_resistance ARO:3008067 ADC-357 ARO:3008067 ADC-357 Extended-spectrum class C beta-lactamase ADC-358. ADC-358 antibiotic_resistance ARO:3008068 ADC-358 ARO:3008068 ADC-358 Class C beta-lactamase ADC-359. ADC-359 antibiotic_resistance ARO:3008069 ADC-359 ARO:3008069 ADC-359 Subclass B1 metallo-beta-lactamase AFM-3. AFM-3 antibiotic_resistance ARO:3008070 AFM-3 ARO:3008070 AFM-3 Subclass B1 metallo-beta-lactamase AFM-4. AFM-4 antibiotic_resistance ARO:3008071 AFM-4 ARO:3008071 AFM-4 Subclass B1 metallo-beta-lactamase AFM-5. AFM-5 antibiotic_resistance ARO:3008072 AFM-5 ARO:3008072 AFM-5 Subclass B3 metallo-beta-lactamase AIM-2. AIM-2 antibiotic_resistance ARO:3008073 AIM-2 ARO:3008073 AIM-2 Class A beta-lactamase ASU1-1. ASU1-1 antibiotic_resistance ARO:3008074 ASU1-1 ARO:3008074 ASU1-1 Carbapenem-hydrolyzing class A beta-lactamase AXC-6. AXC-6 antibiotic_resistance ARO:3008075 AXC-6 ARO:3008075 AXC-6 Carbapenem-hydrolyzing class A beta-lactamase AXC-7. AXC-7 antibiotic_resistance ARO:3008076 AXC-7 ARO:3008076 AXC-7 Carbapenem-hydrolyzing class A beta-lactamase AXC-8. AXC-8 antibiotic_resistance ARO:3008077 AXC-8 ARO:3008077 AXC-8 Subclass B3 metallo-beta-lactamase B3SU1-1. B3SU1-1 antibiotic_resistance ARO:3008078 B3SU1-1 ARO:3008078 B3SU1-1 Subclass B3 metallo-beta-lactamase B3SU2-1. B3SU2-1 antibiotic_resistance ARO:3008079 B3SU2-1 ARO:3008079 B3SU2-1 Carbapenem-hydrolyzing class A beta-lactamase BIC-2. BIC-2 antibiotic_resistance ARO:3008080 BIC-2 ARO:3008080 BIC-2 Subclass B1 metallo-beta-lactamase BMHC-1. BMHC-1 antibiotic_resistance ARO:3008081 BMHC-1 ARO:3008081 BMHC-1 Class A beta-lactamase BOR-1. BOR-1 antibiotic_resistance ARO:3008082 BOR-1 ARO:3008082 BOR-1 Subclass B1 metallo-beta-lactamase CAM-2. CAM-2 antibiotic_resistance ARO:3008083 CAM-2 ARO:3008083 CAM-2 Extended-spectrum class A beta-lactamase CME-3. CME-3 antibiotic_resistance ARO:3008084 CME-3 ARO:3008084 CME-3 Class C beta-lactamase CMH-10. CMH-10 antibiotic_resistance ARO:3008085 CMH-10 ARO:3008085 CMH-10 Class C beta-lactamase CMH-11. CMH-11 antibiotic_resistance ARO:3008086 CMH-11 ARO:3008086 CMH-11 Class C beta-lactamase CMH-12. CMH-12 antibiotic_resistance ARO:3008087 CMH-12 ARO:3008087 CMH-12 Class C beta-lactamase CMH-13. CMH-13 antibiotic_resistance ARO:3008088 CMH-13 ARO:3008088 CMH-13 Class C beta-lactamase CMH-14. CMH-14 antibiotic_resistance ARO:3008089 CMH-14 ARO:3008089 CMH-14 Class C beta-lactamase CMH-15. CMH-15 antibiotic_resistance ARO:3008090 CMH-15 ARO:3008090 CMH-15 Class C beta-lactamase CMH-16. CMH-16 antibiotic_resistance ARO:3008091 CMH-16 ARO:3008091 CMH-16 Class C beta-lactamase CMH-17. CMH-17 antibiotic_resistance ARO:3008092 CMH-17 ARO:3008092 CMH-17 Class C beta-lactamase CMH-18. CMH-18 antibiotic_resistance ARO:3008093 CMH-18 ARO:3008093 CMH-18 Class C beta-lactamase CMH-19. CMH-19 antibiotic_resistance ARO:3008094 CMH-19 ARO:3008094 CMH-19 Class C beta-lactamase CMH-20. CMH-20 antibiotic_resistance ARO:3008095 CMH-20 ARO:3008095 CMH-20 Class C beta-lactamase CMH-21. CMH-21 antibiotic_resistance ARO:3008096 CMH-21 ARO:3008096 CMH-21 Class C beta-lactamase CMH-24. CMH-24 antibiotic_resistance ARO:3008097 CMH-24 ARO:3008097 CMH-24 Class C beta-lactamase CMH-25. CMH-25 antibiotic_resistance ARO:3008098 CMH-25 ARO:3008098 CMH-25 Class C beta-lactamase CMH-26. CMH-26 antibiotic_resistance ARO:3008099 CMH-26 ARO:3008099 CMH-26 Class C beta-lactamase CMH-27. CMH-27 antibiotic_resistance ARO:3008100 CMH-27 ARO:3008100 CMH-27 Class C beta-lactamase CMH-28. CMH-28 antibiotic_resistance ARO:3008101 CMH-28 ARO:3008101 CMH-28 Class C beta-lactamase CMH-29. CMH-29 antibiotic_resistance ARO:3008102 CMH-29 ARO:3008102 CMH-29 Class C beta-lactamase CMH-30. CMH-30 antibiotic_resistance ARO:3008103 CMH-30 ARO:3008103 CMH-30 Class C beta-lactamase CMH-31. CMH-31 antibiotic_resistance ARO:3008104 CMH-31 ARO:3008104 CMH-31 Class C beta-lactamase CMH-32. CMH-32 antibiotic_resistance ARO:3008105 CMH-32 ARO:3008105 CMH-32 Class C beta-lactamase CMH-33. CMH-33 antibiotic_resistance ARO:3008106 CMH-33 ARO:3008106 CMH-33 Class C beta-lactamase CMH-34. CMH-34 antibiotic_resistance ARO:3008107 CMH-34 ARO:3008107 CMH-34 Class C beta-lactamase CMH-7. CMH-7 antibiotic_resistance ARO:3008108 CMH-7 ARO:3008108 CMH-7 Class C beta-lactamase CMH-8. CMH-8 antibiotic_resistance ARO:3008109 CMH-8 ARO:3008109 CMH-8 Class C beta-lactamase CMH-9. CMH-9 antibiotic_resistance ARO:3008110 CMH-9 ARO:3008110 CMH-9 Inhibitor-resistant extended-spectrum class C beta-lactamase CMY-172. CMY-172 antibiotic_resistance ARO:3008111 CMY-172 ARO:3008111 CMY-172 Class C beta-lactamase CMY-175. CMY-175 antibiotic_resistance ARO:3008112 CMY-175 ARO:3008112 CMY-175 Class C beta-lactamase CMY-176. CMY-176 antibiotic_resistance ARO:3008113 CMY-176 ARO:3008113 CMY-176 Class C beta-lactamase CMY-177. CMY-177 antibiotic_resistance ARO:3008114 CMY-177 ARO:3008114 CMY-177 Class C beta-lactamase CMY-178. CMY-178 antibiotic_resistance ARO:3008115 CMY-178 ARO:3008115 CMY-178 Class C beta-lactamase CMY-179. CMY-179 antibiotic_resistance ARO:3008116 CMY-179 ARO:3008116 CMY-179 Class C beta-lactamase CMY-180. CMY-180 antibiotic_resistance ARO:3008117 CMY-180 ARO:3008117 CMY-180 Class C beta-lactamase CMY-181. CMY-181 antibiotic_resistance ARO:3008118 CMY-181 ARO:3008118 CMY-181 Class C beta-lactamase CMY-182. CMY-182 antibiotic_resistance ARO:3008119 CMY-182 ARO:3008119 CMY-182 Class C beta-lactamase CMY-183. CMY-183 antibiotic_resistance ARO:3008120 CMY-183 ARO:3008120 CMY-183 Class C beta-lactamase CMY-184. CMY-184 antibiotic_resistance ARO:3008121 CMY-184 ARO:3008121 CMY-184 Class C beta-lactamase CMY-186. CMY-186 antibiotic_resistance ARO:3008122 CMY-186 ARO:3008122 CMY-186 Class C beta-lactamase CMY-188. CMY-188 antibiotic_resistance ARO:3008123 CMY-188 ARO:3008123 CMY-188 Class C beta-lactamase CMY-189. CMY-189 antibiotic_resistance ARO:3008124 CMY-189 ARO:3008124 CMY-189 Class C beta-lactamase CMY-190. CMY-190 antibiotic_resistance ARO:3008125 CMY-190 ARO:3008125 CMY-190 Class C beta-lactamase CMY-191. CMY-191 antibiotic_resistance ARO:3008126 CMY-191 ARO:3008126 CMY-191 Class C beta-lactamase CMY-192. CMY-192 antibiotic_resistance ARO:3008127 CMY-192 ARO:3008127 CMY-192 Class C beta-lactamase CMY-194. CMY-194 antibiotic_resistance ARO:3008128 CMY-194 ARO:3008128 CMY-194 Class C beta-lactamase CMY-195. CMY-195 antibiotic_resistance ARO:3008129 CMY-195 ARO:3008129 CMY-195 Class C beta-lactamase CMY-196. CMY-196 antibiotic_resistance ARO:3008130 CMY-196 ARO:3008130 CMY-196 Class C beta-lactamase CMY-197. CMY-197 antibiotic_resistance ARO:3008131 CMY-197 ARO:3008131 CMY-197 Class C beta-lactamase CMY-198. CMY-198 antibiotic_resistance ARO:3008132 CMY-198 ARO:3008132 CMY-198 Class C beta-lactamase CMY-199. CMY-199 antibiotic_resistance ARO:3008133 CMY-199 ARO:3008133 CMY-199 Extended-spectrum class A beta-lactamase CTX-M-243. CTX-M-243 antibiotic_resistance ARO:3008134 CTX-M-243 ARO:3008134 CTX-M-243 Extended-spectrum class A beta-lactamase CTX-M-245. CTX-M-245 antibiotic_resistance ARO:3008135 CTX-M-245 ARO:3008135 CTX-M-245 Extended-spectrum class A beta-lactamase CTX-M-246. CTX-M-246 antibiotic_resistance ARO:3008136 CTX-M-246 ARO:3008136 CTX-M-246 Extended-spectrum class A beta-lactamase CTX-M-247. CTX-M-247 antibiotic_resistance ARO:3008137 CTX-M-247 ARO:3008137 CTX-M-247 Extended-spectrum class A beta-lactamase CTX-M-248. CTX-M-248 antibiotic_resistance ARO:3008138 CTX-M-248 ARO:3008138 CTX-M-248 Extended-spectrum class A beta-lactamase CTX-M-249. CTX-M-249 antibiotic_resistance ARO:3008139 CTX-M-249 ARO:3008139 CTX-M-249 Extended-spectrum class A beta-lactamase CTX-M-251. CTX-M-251 antibiotic_resistance ARO:3008140 CTX-M-251 ARO:3008140 CTX-M-251 Extended-spectrum class A beta-lactamase CTX-M-252. CTX-M-252 antibiotic_resistance ARO:3008141 CTX-M-252 ARO:3008141 CTX-M-252 Extended-spectrum class A beta-lactamase CTX-M-253. CTX-M-253 antibiotic_resistance ARO:3008142 CTX-M-253 ARO:3008142 CTX-M-253 Extended-spectrum class A beta-lactamase CTX-M-254. CTX-M-254 antibiotic_resistance ARO:3008143 CTX-M-254 ARO:3008143 CTX-M-254 Inhibitor-resistant class A beta-lactamase CTX-M-255. CTX-M-255 antibiotic_resistance ARO:3008144 CTX-M-255 ARO:3008144 CTX-M-255 Extended-spectrum class A beta-lactamase CTX-M-256. CTX-M-256 antibiotic_resistance ARO:3008145 CTX-M-256 ARO:3008145 CTX-M-256 Extended-spectrum class A beta-lactamase CTX-M-257. CTX-M-257 antibiotic_resistance ARO:3008146 CTX-M-257 ARO:3008146 CTX-M-257 Extended-spectrum class A beta-lactamase CTX-M-258. CTX-M-258 antibiotic_resistance ARO:3008147 CTX-M-258 ARO:3008147 CTX-M-258 Extended-spectrum class A beta-lactamase CTX-M-259. CTX-M-259 antibiotic_resistance ARO:3008148 CTX-M-259 ARO:3008148 CTX-M-259 Extended-spectrum class A beta-lactamase CTX-M-260. CTX-M-260 antibiotic_resistance ARO:3008149 CTX-M-260 ARO:3008149 CTX-M-260 Extended-spectrum class A beta-lactamase CTX-M-261. CTX-M-261 antibiotic_resistance ARO:3008150 CTX-M-261 ARO:3008150 CTX-M-261 Extended-spectrum class A beta-lactamase CTX-M-262. CTX-M-262 antibiotic_resistance ARO:3008151 CTX-M-262 ARO:3008151 CTX-M-262 Extended-spectrum class A beta-lactamase CTX-M-263. CTX-M-263 antibiotic_resistance ARO:3008152 CTX-M-263 ARO:3008152 CTX-M-263 Extended-spectrum class A beta-lactamase CTX-M-264. CTX-M-264 antibiotic_resistance ARO:3008153 CTX-M-264 ARO:3008153 CTX-M-264 Extended-spectrum class A beta-lactamase CTX-M-265. CTX-M-265 antibiotic_resistance ARO:3008154 CTX-M-265 ARO:3008154 CTX-M-265 Extended-spectrum class A beta-lactamase CTX-M-266. CTX-M-266 antibiotic_resistance ARO:3008155 CTX-M-266 ARO:3008155 CTX-M-266 Extended-spectrum class A beta-lactamase CTX-M-267. CTX-M-267 antibiotic_resistance ARO:3008156 CTX-M-267 ARO:3008156 CTX-M-267 Extended-spectrum class A beta-lactamase CTX-M-268. CTX-M-268 antibiotic_resistance ARO:3008157 CTX-M-268 ARO:3008157 CTX-M-268 Extended-spectrum class A beta-lactamase CTX-M-269. CTX-M-269 antibiotic_resistance ARO:3008158 CTX-M-269 ARO:3008158 CTX-M-269 Extended-spectrum class A beta-lactamase CTX-M-270. CTX-M-270 antibiotic_resistance ARO:3008159 CTX-M-270 ARO:3008159 CTX-M-270 Extended-spectrum class A beta-lactamase CTX-M-271. CTX-M-271 antibiotic_resistance ARO:3008160 CTX-M-271 ARO:3008160 CTX-M-271 Extended-spectrum class A beta-lactamase CTX-M-272. CTX-M-272 antibiotic_resistance ARO:3008161 CTX-M-272 ARO:3008161 CTX-M-272 Extended-spectrum class A beta-lactamase CTX-M-273. CTX-M-273 antibiotic_resistance ARO:3008162 CTX-M-273 ARO:3008162 CTX-M-273 Extended-spectrum class A beta-lactamase CTX-M-274. CTX-M-274 antibiotic_resistance ARO:3008163 CTX-M-274 ARO:3008163 CTX-M-274 Extended-spectrum class A beta-lactamase CTX-M-275. CTX-M-275 antibiotic_resistance ARO:3008164 CTX-M-275 ARO:3008164 CTX-M-275 Extended-spectrum class A beta-lactamase CTX-M-276. CTX-M-276 antibiotic_resistance ARO:3008165 CTX-M-276 ARO:3008165 CTX-M-276 Extended-spectrum class A beta-lactamase CTX-M-277. CTX-M-277 antibiotic_resistance ARO:3008166 CTX-M-277 ARO:3008166 CTX-M-277 Extended-spectrum class A beta-lactamase CTX-M-278. CTX-M-278 antibiotic_resistance ARO:3008167 CTX-M-278 ARO:3008167 CTX-M-278 Class C beta-lactamase DHA-30. DHA-30 antibiotic_resistance ARO:3008168 DHA-30 ARO:3008168 DHA-30 Class C beta-lactamase DHA-31. DHA-31 antibiotic_resistance ARO:3008169 DHA-31 ARO:3008169 DHA-31 Class C beta-lactamase DHA-32. DHA-32 antibiotic_resistance ARO:3008170 DHA-32 ARO:3008170 DHA-32 Class C beta-lactamase DHA-33. DHA-33 antibiotic_resistance ARO:3008171 DHA-33 ARO:3008171 DHA-33 Class C beta-lactamase DHA-34. DHA-34 antibiotic_resistance ARO:3008172 DHA-34 ARO:3008172 DHA-34 Class A beta-lactamase FONA-10. FONA-10 antibiotic_resistance ARO:3008173 FONA-10 ARO:3008173 FONA-10 Class A beta-lactamase FONA-11. FONA-11 antibiotic_resistance ARO:3008174 FONA-11 ARO:3008174 FONA-11 Class A beta-lactamase FONA-12. FONA-12 antibiotic_resistance ARO:3008175 FONA-12 ARO:3008175 FONA-12 Class A beta-lactamase FONA-13. FONA-13 antibiotic_resistance ARO:3008176 FONA-13 ARO:3008176 FONA-13 Class A beta-lactamase FONA-7. FONA-7 antibiotic_resistance ARO:3008177 FONA-7 ARO:3008177 FONA-7 Class A beta-lactamase FONA-8. FONA-8 antibiotic_resistance ARO:3008178 FONA-8 ARO:3008178 FONA-8 Class A beta-lactamase FONA-9. FONA-9 antibiotic_resistance ARO:3008179 FONA-9 ARO:3008179 FONA-9 Cephalosporin-hydrolyzing class C beta-lactamase FOX-18. FOX-18 antibiotic_resistance ARO:3008180 FOX-18 ARO:3008180 FOX-18 Cephalosporin-hydrolyzing class C beta-lactamase FOX-19. FOX-19 antibiotic_resistance ARO:3008181 FOX-19 ARO:3008181 FOX-19 Cephalosporin-hydrolyzing class C beta-lactamase FOX-20. FOX-20 antibiotic_resistance ARO:3008182 FOX-20 ARO:3008182 FOX-20 Cephalosporin-hydrolyzing class C beta-lactamase FOX-21. FOX-21 antibiotic_resistance ARO:3008183 FOX-21 ARO:3008183 FOX-21 Carbapenem-hydrolyzing class A beta-lactamase FRI-12. FRI-12 antibiotic_resistance ARO:3008184 FRI-12 ARO:3008184 FRI-12 Class A beta-lactamase GES-58. GES-58 antibiotic_resistance ARO:3008185 GES-58 ARO:3008185 GES-58 Class A beta-lactamase GES-59. GES-59 antibiotic_resistance ARO:3008186 GES-59 ARO:3008186 GES-59 Extended-spectrum class A beta-lactamase GES-60. GES-60 antibiotic_resistance ARO:3008187 GES-60 ARO:3008187 GES-60 Class A beta-lactamase GES-61. GES-61 antibiotic_resistance ARO:3008188 GES-61 ARO:3008188 GES-61 Class A beta-lactamase GES-62. GES-62 antibiotic_resistance ARO:3008189 GES-62 ARO:3008189 GES-62 Class A beta-lactamase GES-65. GES-65 antibiotic_resistance ARO:3008190 GES-65 ARO:3008190 GES-65 Carbapenem-hydrolyzing class A beta-lactamase GES-66. GES-66 antibiotic_resistance ARO:3008191 GES-66 ARO:3008191 GES-66 Subclass B1 metallo-beta-lactamase GIM-3. GIM-3 antibiotic_resistance ARO:3008192 GIM-3 ARO:3008192 GIM-3 GMA family class A beta-lactamase GMA-1. GMA-1 antibiotic_resistance ARO:3008193 GMA-1 ARO:3008193 GMA-1 GMA family class A beta-lactamase GMA-2. GMA-2 antibiotic_resistance ARO:3008194 GMA-2 ARO:3008194 GMA-2 Subclass B3 metallo-beta-lactamase GOB-17. GOB-17 antibiotic_resistance ARO:3008195 GOB-17 ARO:3008195 GOB-17 Subclass B3 metallo-beta-lactamase GOB-47. GOB-47 antibiotic_resistance ARO:3008196 GOB-47 ARO:3008196 GOB-47 Subclass B3 metallo-beta-lactamase GOB-52. GOB-52 antibiotic_resistance ARO:3008197 GOB-52 ARO:3008197 GOB-52 Subclass B3 metallo-beta-lactamase GOB-53. GOB-53 antibiotic_resistance ARO:3008198 GOB-53 ARO:3008198 GOB-53 Class A beta-lactamase HBL-1. HBL-1 antibiotic_resistance ARO:3008199 HBL-1 ARO:3008199 HBL-1 Penicillin-hydrolyzing class A beta-lactamase HER-1. HER-1 HERA-1 antibiotic_resistance ARO:3008200 HER-1 ARO:3008200 HER-1 Class A beta-lactamase HER-2. HER-2 HERA-2 antibiotic_resistance ARO:3008201 HER-2 ARO:3008201 HER-2 Class A beta-lactamase HER-3. HER-3 HERA-3 antibiotic_resistance ARO:3008202 HER-3 ARO:3008202 HER-3 Class A beta-lactamase HER-4. HER-4 HERA-4 antibiotic_resistance ARO:3008203 HER-4 ARO:3008203 HER-4 Class A beta-lactamase HER-5. HER-5 HERA-5 antibiotic_resistance ARO:3008204 HER-5 ARO:3008204 HER-5 Class A beta-lactamase HER-6. HER-6 HERA-6 antibiotic_resistance ARO:3008205 HER-6 ARO:3008205 HER-6 Class A beta-lactamase HER-8. HER-8 HERA-8 antibiotic_resistance ARO:3008206 HER-8 ARO:3008206 HER-8 Subclass B1 metallo-beta-lactamase HMB-2. HMB-2 antibiotic_resistance ARO:3008207 HMB-2 ARO:3008207 HMB-2 Carbapenem-hydrolyzing class A beta-lactamase IMI-10. IMI-10 antibiotic_resistance ARO:3008208 IMI-10 ARO:3008208 IMI-10 Carbapenem-hydrolyzing class A beta-lactamase IMI-22. IMI-22 antibiotic_resistance ARO:3008209 IMI-22 ARO:3008209 IMI-22 Carbapenem-hydrolyzing class A beta-lactamase IMI-23. IMI-23 antibiotic_resistance ARO:3008210 IMI-23 ARO:3008210 IMI-23 Carbapenem-hydrolyzing class A beta-lactamase IMI-24. IMI-24 antibiotic_resistance ARO:3008211 IMI-24 ARO:3008211 IMI-24 Carbapenem-hydrolyzing class A beta-lactamase IMI-25. IMI-25 antibiotic_resistance ARO:3008212 IMI-25 ARO:3008212 IMI-25 Carbapenem-hydrolyzing class A beta-lactamase IMI-26. IMI-26 antibiotic_resistance ARO:3008213 IMI-26 ARO:3008213 IMI-26 Carbapenem-hydrolyzing class A beta-lactamase IMI-27. IMI-27 antibiotic_resistance ARO:3008214 IMI-27 ARO:3008214 IMI-27 Subclass B1 metallo-beta-lactamase IMP-100. IMP-100 antibiotic_resistance ARO:3008215 IMP-100 ARO:3008215 IMP-100 Subclass B1 metallo-beta-lactamase IMP-101. IMP-101 antibiotic_resistance ARO:3008216 IMP-101 ARO:3008216 IMP-101 Subclass B1 metallo-beta-lactamase IMP-102. IMP-102 antibiotic_resistance ARO:3008217 IMP-102 ARO:3008217 IMP-102 Subclass B1 metallo-beta-lactamase IMP-104. IMP-104 antibiotic_resistance ARO:3008218 IMP-104 ARO:3008218 IMP-104 Subclass B1 metallo-beta-lactamase IMP-105. IMP-105 antibiotic_resistance ARO:3008219 IMP-105 ARO:3008219 IMP-105 Subclass B1 metallo-beta-lactamase IMP-86. IMP-86 antibiotic_resistance ARO:3008220 IMP-86 ARO:3008220 IMP-86 Subclass B1 metallo-beta-lactamase IMP-87. IMP-87 antibiotic_resistance ARO:3008221 IMP-87 ARO:3008221 IMP-87 Subclass B1 metallo-beta-lactamase IMP-90. IMP-90 antibiotic_resistance ARO:3008222 IMP-90 ARO:3008222 IMP-90 Subclass B1 metallo-beta-lactamase IMP-97. IMP-97 antibiotic_resistance ARO:3008223 IMP-97 ARO:3008223 IMP-97 Subclass B1 metallo-beta-lactamase IMP-98. IMP-98 antibiotic_resistance ARO:3008224 IMP-98 ARO:3008224 IMP-98 Subclass B1 metallo-beta-lactamase IMP-99. IMP-99 antibiotic_resistance ARO:3008225 IMP-99 ARO:3008225 IMP-99 Subclass B1 metallo-beta-lactamase IND-18. IND-18 antibiotic_resistance ARO:3008226 IND-18 ARO:3008226 IND-18 Subclass B1 metallo-beta-lactamase IND-19. IND-19 antibiotic_resistance ARO:3008227 IND-19 ARO:3008227 IND-19 Subclass B1 metallo-beta-lactamase KHM-2. KHM-2 antibiotic_resistance ARO:3008228 KHM-2 ARO:3008228 KHM-2 Extended-spectrum class A beta-lactamase KLUC-6. KLUC-6 antibiotic_resistance ARO:3008229 KLUC-6 ARO:3008229 KLUC-6 CTX-M family extended-spectrum class A beta-lactamase KLUG-1. KLUG-1 antibiotic_resistance ARO:3008230 KLUG-1 ARO:3008230 KLUG-1 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-101. KPC-101 antibiotic_resistance ARO:3008231 KPC-101 ARO:3008231 KPC-101 Carbapenem-hydrolyzing class A beta-lactamase KPC-102. KPC-102 antibiotic_resistance ARO:3008232 KPC-102 ARO:3008232 KPC-102 Class A beta-lactamase KPC-103. KPC-103 antibiotic_resistance ARO:3008233 KPC-103 ARO:3008233 KPC-103 Class A beta-lactamase KPC-104. KPC-104 antibiotic_resistance ARO:3008234 KPC-104 ARO:3008234 KPC-104 Class A beta-lactamase KPC-105. KPC-105 antibiotic_resistance ARO:3008235 KPC-105 ARO:3008235 KPC-105 Class A beta-lactamase KPC-106. KPC-106 antibiotic_resistance ARO:3008236 KPC-106 ARO:3008236 KPC-106 Class A beta-lactamase KPC-107. KPC-107 antibiotic_resistance ARO:3008237 KPC-107 ARO:3008237 KPC-107 Class A beta-lactamase KPC-108. KPC-108 antibiotic_resistance ARO:3008238 KPC-108 ARO:3008238 KPC-108 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-109. KPC-109 antibiotic_resistance ARO:3008239 KPC-109 ARO:3008239 KPC-109 Inhibitor-resistant class A beta-lactamase KPC-110. KPC-110 antibiotic_resistance ARO:3008240 KPC-110 ARO:3008240 KPC-110 Inhibitor-resistant class A beta-lactamase KPC-111. KPC-111 antibiotic_resistance ARO:3008241 KPC-111 ARO:3008241 KPC-111 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-112. KPC-112 antibiotic_resistance ARO:3008242 KPC-112 ARO:3008242 KPC-112 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-113. KPC-113 antibiotic_resistance ARO:3008243 KPC-113 ARO:3008243 KPC-113 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-114. KPC-114 antibiotic_resistance ARO:3008244 KPC-114 ARO:3008244 KPC-114 Inhibitor-resistant class A beta-lactamase KPC-115. KPC-115 antibiotic_resistance ARO:3008245 KPC-115 ARO:3008245 KPC-115 Carbapenem-hydrolyzing class A beta-lactamase KPC-116. KPC-116 antibiotic_resistance ARO:3008246 KPC-116 ARO:3008246 KPC-116 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-117. KPC-117 antibiotic_resistance ARO:3008247 KPC-117 ARO:3008247 KPC-117 Carbapenem-hydrolyzing class A beta-lactamase KPC-118. KPC-118 antibiotic_resistance ARO:3008248 KPC-118 ARO:3008248 KPC-118 Carbapenem-hydrolyzing class A beta-lactamase KPC-119. KPC-119 antibiotic_resistance ARO:3008249 KPC-119 ARO:3008249 KPC-119 Carbapenem-hydrolyzing class A beta-lactamase KPC-120. KPC-120 antibiotic_resistance ARO:3008250 KPC-120 ARO:3008250 KPC-120 Carbapenem-hydrolyzing class A beta-lactamase KPC-121. KPC-121 antibiotic_resistance ARO:3008251 KPC-121 ARO:3008251 KPC-121 Carbapenem-hydrolyzing class A beta-lactamase KPC-122. KPC-122 antibiotic_resistance ARO:3008252 KPC-122 ARO:3008252 KPC-122 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-124. KPC-124 antibiotic_resistance ARO:3008253 KPC-124 ARO:3008253 KPC-124 Carbapenem-hydrolyzing class A beta-lactamase KPC-126. KPC-126 antibiotic_resistance ARO:3008254 KPC-126 ARO:3008254 KPC-126 Carbapenem-hydrolyzing class A beta-lactamase KPC-127. KPC-127 antibiotic_resistance ARO:3008255 KPC-127 ARO:3008255 KPC-127 Carbapenem-hydrolyzing class A beta-lactamase KPC-128. KPC-128 antibiotic_resistance ARO:3008256 KPC-128 ARO:3008256 KPC-128 Class A beta-lactamase KPC-129. KPC-129 antibiotic_resistance ARO:3008257 KPC-129 ARO:3008257 KPC-129 Class A beta-lactamase KPC-130. KPC-130 antibiotic_resistance ARO:3008258 KPC-130 ARO:3008258 KPC-130 Carbapenem-hydrolyzing class A beta-lactamase KPC-131. KPC-131 antibiotic_resistance ARO:3008259 KPC-131 ARO:3008259 KPC-131 Inhibitor-resistant class A beta-lactamase KPC-132. KPC-132 antibiotic_resistance ARO:3008260 KPC-132 ARO:3008260 KPC-132 Carbapenem-hydrolyzing class A beta-lactamase KPC-133. KPC-133 antibiotic_resistance ARO:3008261 KPC-133 ARO:3008261 KPC-133 Carbapenem-hydrolyzing class A beta-lactamase KPC-136. KPC-136 antibiotic_resistance ARO:3008262 KPC-136 ARO:3008262 KPC-136 Inhibitor-resistant class A beta-lactamase KPC-137. KPC-137 antibiotic_resistance ARO:3008263 KPC-137 ARO:3008263 KPC-137 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-138. KPC-138 antibiotic_resistance ARO:3008264 KPC-138 ARO:3008264 KPC-138 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-139. KPC-139 antibiotic_resistance ARO:3008265 KPC-139 ARO:3008265 KPC-139 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-140. KPC-140 antibiotic_resistance ARO:3008266 KPC-140 ARO:3008266 KPC-140 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-141. KPC-141 antibiotic_resistance ARO:3008267 KPC-141 ARO:3008267 KPC-141 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-142. KPC-142 antibiotic_resistance ARO:3008268 KPC-142 ARO:3008268 KPC-142 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-143. KPC-143 antibiotic_resistance ARO:3008269 KPC-143 ARO:3008269 KPC-143 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-144. KPC-144 antibiotic_resistance ARO:3008270 KPC-144 ARO:3008270 KPC-144 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-145. KPC-145 antibiotic_resistance ARO:3008271 KPC-145 ARO:3008271 KPC-145 Carbapenem-hydrolyzing class A beta-lactamase KPC-146. KPC-146 antibiotic_resistance ARO:3008272 KPC-146 ARO:3008272 KPC-146 Carbapenem-hydrolyzing class A beta-lactamase KPC-147. KPC-147 antibiotic_resistance ARO:3008273 KPC-147 ARO:3008273 KPC-147 Class A beta-lactamase KPC-148. KPC-148 antibiotic_resistance ARO:3008274 KPC-148 ARO:3008274 KPC-148 Carbapenem-hydrolyzing class A beta-lactamase KPC-149. KPC-149 antibiotic_resistance ARO:3008275 KPC-149 ARO:3008275 KPC-149 Inhibitor-resistant class A beta-lactamase KPC-150. KPC-150 antibiotic_resistance ARO:3008276 KPC-150 ARO:3008276 KPC-150 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-151. KPC-151 antibiotic_resistance ARO:3008277 KPC-151 ARO:3008277 KPC-151 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-152. KPC-152 antibiotic_resistance ARO:3008278 KPC-152 ARO:3008278 KPC-152 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-153. KPC-153 antibiotic_resistance ARO:3008279 KPC-153 ARO:3008279 KPC-153 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-154. KPC-154 antibiotic_resistance ARO:3008280 KPC-154 ARO:3008280 KPC-154 Inhibitor-resistant class A beta-lactamase KPC-155. KPC-155 antibiotic_resistance ARO:3008281 KPC-155 ARO:3008281 KPC-155 Carbapenem-hydrolyzing class A beta-lactamase KPC-156. KPC-156 antibiotic_resistance ARO:3008282 KPC-156 ARO:3008282 KPC-156 Carbapenem-hydrolyzing class A beta-lactamase KPC-157. KPC-157 antibiotic_resistance ARO:3008283 KPC-157 ARO:3008283 KPC-157 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-158. KPC-158 antibiotic_resistance ARO:3008284 KPC-158 ARO:3008284 KPC-158 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-159. KPC-159 antibiotic_resistance ARO:3008285 KPC-159 ARO:3008285 KPC-159 Carbapenem-hydrolyzing class A beta-lactamase KPC-160. KPC-160 antibiotic_resistance ARO:3008286 KPC-160 ARO:3008286 KPC-160 Carbapenem-hydrolyzing class A beta-lactamase KPC-161. KPC-161 antibiotic_resistance ARO:3008287 KPC-161 ARO:3008287 KPC-161 Carbapenem-hydrolyzing class A beta-lactamase KPC-162. KPC-162 antibiotic_resistance ARO:3008288 KPC-162 ARO:3008288 KPC-162 Carbapenem-hydrolyzing class A beta-lactamase KPC-163. KPC-163 antibiotic_resistance ARO:3008289 KPC-163 ARO:3008289 KPC-163 Carbapenem-hydrolyzing class A beta-lactamase KPC-164. KPC-164 antibiotic_resistance ARO:3008290 KPC-164 ARO:3008290 KPC-164 Carbapenem-hydrolyzing class A beta-lactamase KPC-165. KPC-165 antibiotic_resistance ARO:3008291 KPC-165 ARO:3008291 KPC-165 Carbapenem-hydrolyzing class A beta-lactamase KPC-166. KPC-166 antibiotic_resistance ARO:3008292 KPC-166 ARO:3008292 KPC-166 Class A beta-lactamase KPC-167. KPC-167 antibiotic_resistance ARO:3008293 KPC-167 ARO:3008293 KPC-167 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-168. KPC-168 antibiotic_resistance ARO:3008294 KPC-168 ARO:3008294 KPC-168 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-169. KPC-169 antibiotic_resistance ARO:3008295 KPC-169 ARO:3008295 KPC-169 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-170. KPC-170 antibiotic_resistance ARO:3008296 KPC-170 ARO:3008296 KPC-170 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-171. KPC-171 antibiotic_resistance ARO:3008297 KPC-171 ARO:3008297 KPC-171 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-172. KPC-172 antibiotic_resistance ARO:3008298 KPC-172 ARO:3008298 KPC-172 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-173. KPC-173 antibiotic_resistance ARO:3008299 KPC-173 ARO:3008299 KPC-173 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-174. KPC-174 antibiotic_resistance ARO:3008300 KPC-174 ARO:3008300 KPC-174 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-175. KPC-175 antibiotic_resistance ARO:3008301 KPC-175 ARO:3008301 KPC-175 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-176. KPC-176 antibiotic_resistance ARO:3008302 KPC-176 ARO:3008302 KPC-176 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-177. KPC-177 antibiotic_resistance ARO:3008303 KPC-177 ARO:3008303 KPC-177 Inhibitor-resistant class A beta-lactamase KPC-178. KPC-178 antibiotic_resistance ARO:3008304 KPC-178 ARO:3008304 KPC-178 Class A beta-lactamase KPC-179. KPC-179 antibiotic_resistance ARO:3008305 KPC-179 ARO:3008305 KPC-179 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-180. KPC-180 antibiotic_resistance ARO:3008306 KPC-180 ARO:3008306 KPC-180 Carbapenem-hydrolyzing class A beta-lactamase KPC-181. KPC-181 antibiotic_resistance ARO:3008307 KPC-181 ARO:3008307 KPC-181 Carbapenem-hydrolyzing class A beta-lactamase KPC-182. KPC-182 antibiotic_resistance ARO:3008308 KPC-182 ARO:3008308 KPC-182 Carbapenem-hydrolyzing class A beta-lactamase KPC-183. KPC-183 antibiotic_resistance ARO:3008309 KPC-183 ARO:3008309 KPC-183 Carbapenem-hydrolyzing class A beta-lactamase KPC-184. KPC-184 antibiotic_resistance ARO:3008310 KPC-184 ARO:3008310 KPC-184 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-185. KPC-185 antibiotic_resistance ARO:3008311 KPC-185 ARO:3008311 KPC-185 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-186. KPC-186 antibiotic_resistance ARO:3008312 KPC-186 ARO:3008312 KPC-186 Inhibitor-resistant class A beta-lactamase KPC-187. KPC-187 antibiotic_resistance ARO:3008313 KPC-187 ARO:3008313 KPC-187 Inhibitor-resistant class A beta-lactamase KPC-188. KPC-188 antibiotic_resistance ARO:3008314 KPC-188 ARO:3008314 KPC-188 Extended-spectrum class A beta-lactamase KPC-189. KPC-189 antibiotic_resistance ARO:3008315 KPC-189 ARO:3008315 KPC-189 Inhibitor-resistant class A beta-lactamase KPC-190. KPC-190 antibiotic_resistance ARO:3008316 KPC-190 ARO:3008316 KPC-190 Inhibitor-resistant class A beta-lactamase KPC-191. KPC-191 antibiotic_resistance ARO:3008317 KPC-191 ARO:3008317 KPC-191 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-192. KPC-192 antibiotic_resistance ARO:3008318 KPC-192 ARO:3008318 KPC-192 Class A beta-lactamase KPC-193. KPC-193 antibiotic_resistance ARO:3008319 KPC-193 ARO:3008319 KPC-193 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-194. KPC-194 antibiotic_resistance ARO:3008320 KPC-194 ARO:3008320 KPC-194 Carbapenem-hydrolyzing class A beta-lactamase KPC-195. KPC-195 antibiotic_resistance ARO:3008321 KPC-195 ARO:3008321 KPC-195 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-196. KPC-196 antibiotic_resistance ARO:3008322 KPC-196 ARO:3008322 KPC-196 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-197. KPC-197 antibiotic_resistance ARO:3008323 KPC-197 ARO:3008323 KPC-197 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-201. KPC-201 antibiotic_resistance ARO:3008324 KPC-201 ARO:3008324 KPC-201 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-202. KPC-202 antibiotic_resistance ARO:3008325 KPC-202 ARO:3008325 KPC-202 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-203. KPC-203 antibiotic_resistance ARO:3008326 KPC-203 ARO:3008326 KPC-203 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-204. KPC-204 antibiotic_resistance ARO:3008327 KPC-204 ARO:3008327 KPC-204 Inhibitor-resistant class A beta-lactamase KPC-205. KPC-205 antibiotic_resistance ARO:3008328 KPC-205 ARO:3008328 KPC-205 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-206. KPC-206 antibiotic_resistance ARO:3008329 KPC-206 ARO:3008329 KPC-206 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-207. KPC-207 antibiotic_resistance ARO:3008330 KPC-207 ARO:3008330 KPC-207 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-208. KPC-208 antibiotic_resistance ARO:3008331 KPC-208 ARO:3008331 KPC-208 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-209. KPC-209 antibiotic_resistance ARO:3008332 KPC-209 ARO:3008332 KPC-209 Carbapenem-hydrolyzing class A beta-lactamase KPC-211. KPC-211 antibiotic_resistance ARO:3008333 KPC-211 ARO:3008333 KPC-211 Carbapenem-hydrolyzing class A beta-lactamase KPC-212. KPC-212 antibiotic_resistance ARO:3008334 KPC-212 ARO:3008334 KPC-212 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-213. KPC-213 antibiotic_resistance ARO:3008335 KPC-213 ARO:3008335 KPC-213 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-214. KPC-214 antibiotic_resistance ARO:3008336 KPC-214 ARO:3008336 KPC-214 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-215. KPC-215 antibiotic_resistance ARO:3008337 KPC-215 ARO:3008337 KPC-215 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-216. KPC-216 antibiotic_resistance ARO:3008338 KPC-216 ARO:3008338 KPC-216 Inhibitor-resistant class A beta-lactamase KPC-217. KPC-217 antibiotic_resistance ARO:3008339 KPC-217 ARO:3008339 KPC-217 Inhibitor-resistant class A beta-lactamase KPC-218. KPC-218 antibiotic_resistance ARO:3008340 KPC-218 ARO:3008340 KPC-218 Carbapenem-hydrolyzing class A beta-lactamase KPC-223. KPC-223 antibiotic_resistance ARO:3008341 KPC-223 ARO:3008341 KPC-223 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-224. KPC-224 antibiotic_resistance ARO:3008342 KPC-224 ARO:3008342 KPC-224 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-225. KPC-225 antibiotic_resistance ARO:3008343 KPC-225 ARO:3008343 KPC-225 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-226. KPC-226 antibiotic_resistance ARO:3008344 KPC-226 ARO:3008344 KPC-226 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-227. KPC-227 antibiotic_resistance ARO:3008345 KPC-227 ARO:3008345 KPC-227 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-228. KPC-228 antibiotic_resistance ARO:3008346 KPC-228 ARO:3008346 KPC-228 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-230. KPC-230 antibiotic_resistance ARO:3008347 KPC-230 ARO:3008347 KPC-230 Carbapenem-hydrolyzing class A beta-lactamase KPC-231. KPC-231 antibiotic_resistance ARO:3008348 KPC-231 ARO:3008348 KPC-231 Carbapenem-hydrolyzing class A beta-lactamase KPC-232. KPC-232 antibiotic_resistance ARO:3008349 KPC-232 ARO:3008349 KPC-232 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-233. KPC-233 antibiotic_resistance ARO:3008350 KPC-233 ARO:3008350 KPC-233 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-234. KPC-234 antibiotic_resistance ARO:3008351 KPC-234 ARO:3008351 KPC-234 Carbapenem-hydrolyzing class A beta-lactamase KPC-236. KPC-236 antibiotic_resistance ARO:3008352 KPC-236 ARO:3008352 KPC-236 Carbapenem-hydrolyzing class A beta-lactamase KPC-237. KPC-237 antibiotic_resistance ARO:3008353 KPC-237 ARO:3008353 KPC-237 Carbapenem-hydrolyzing class A beta-lactamase KPC-238. KPC-238 antibiotic_resistance ARO:3008354 KPC-238 ARO:3008354 KPC-238 Carbapenem-hydrolyzing class A beta-lactamase KPC-239. KPC-239 antibiotic_resistance ARO:3008355 KPC-239 ARO:3008355 KPC-239 Carbapenem-hydrolyzing class A beta-lactamase KPC-240. KPC-240 antibiotic_resistance ARO:3008356 KPC-240 ARO:3008356 KPC-240 Carbapenem-hydrolyzing class A beta-lactamase KPC-241. KPC-241 antibiotic_resistance ARO:3008357 KPC-241 ARO:3008357 KPC-241 Carbapenem-hydrolyzing class A beta-lactamase KPC-242. KPC-242 antibiotic_resistance ARO:3008358 KPC-242 ARO:3008358 KPC-242 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-47. KPC-47 antibiotic_resistance ARO:3008359 KPC-47 ARO:3008359 KPC-47 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-48. KPC-48 antibiotic_resistance ARO:3008360 KPC-48 ARO:3008360 KPC-48 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-53. KPC-53 antibiotic_resistance ARO:3008361 KPC-53 ARO:3008361 KPC-53 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-67. KPC-67 antibiotic_resistance ARO:3008362 KPC-67 ARO:3008362 KPC-67 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-68. KPC-68 antibiotic_resistance ARO:3008363 KPC-68 ARO:3008363 KPC-68 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-69. KPC-69 antibiotic_resistance ARO:3008364 KPC-69 ARO:3008364 KPC-69 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-70. KPC-70 antibiotic_resistance ARO:3008365 KPC-70 ARO:3008365 KPC-70 Inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-84. KPC-84 antibiotic_resistance ARO:3008366 KPC-84 ARO:3008366 KPC-84 Carbapenem-hydrolyzing class A beta-lactamase KPC-85. KPC-85 antibiotic_resistance ARO:3008367 KPC-85 ARO:3008367 KPC-85 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-88. KPC-88 antibiotic_resistance ARO:3008368 KPC-88 ARO:3008368 KPC-88 Carbapenem-hydrolyzing class A beta-lactamase KPC-89. KPC-89 antibiotic_resistance ARO:3008369 KPC-89 ARO:3008369 KPC-89 Carbapenem-hydrolyzing class A beta-lactamase KPC-91. KPC-91 antibiotic_resistance ARO:3008370 KPC-91 ARO:3008370 KPC-91 Inhibitor-resistant extended-spectrum class A beta-lactamase KPC-92. KPC-92 antibiotic_resistance ARO:3008371 KPC-92 ARO:3008371 KPC-92 Class C beta-lactamase LHK-7. LHK-7 antibiotic_resistance ARO:3008372 LHK-7 ARO:3008372 LHK-7 Cephalosporin-hydrolyzing class C beta-lactamase MIR-24. MIR-24 antibiotic_resistance ARO:3008373 MIR-24 ARO:3008373 MIR-24 Cephalosporin-hydrolyzing class C beta-lactamase MIR-25. MIR-25 antibiotic_resistance ARO:3008374 MIR-25 ARO:3008374 MIR-25 Cephalosporin-hydrolyzing class C beta-lactamase MIR-27. MIR-27 antibiotic_resistance ARO:3008375 MIR-27 ARO:3008375 MIR-27 Cephalosporin-hydrolyzing class C beta-lactamase MIR-28. MIR-28 antibiotic_resistance ARO:3008376 MIR-28 ARO:3008376 MIR-28 Cephalosporin-hydrolyzing class C beta-lactamase MIR-30. MIR-30 antibiotic_resistance ARO:3008377 MIR-30 ARO:3008377 MIR-30 Cephalosporin-hydrolyzing class C beta-lactamase MIR-31. MIR-31 antibiotic_resistance ARO:3008378 MIR-31 ARO:3008378 MIR-31 Cephalosporin-hydrolyzing class C beta-lactamase MIR-32. MIR-32 antibiotic_resistance ARO:3008379 MIR-32 ARO:3008379 MIR-32 Cephalosporin-hydrolyzing class C beta-lactamase MIR-33. MIR-33 antibiotic_resistance ARO:3008380 MIR-33 ARO:3008380 MIR-33 Cephalosporin-hydrolyzing class C beta-lactamase MIR-34. MIR-34 antibiotic_resistance ARO:3008381 MIR-34 ARO:3008381 MIR-34 Cephalosporin-hydrolyzing class C beta-lactamase MIR-35. MIR-35 antibiotic_resistance ARO:3008382 MIR-35 ARO:3008382 MIR-35 CMY-1/MOX family class C beta-lactamase MOX-15. MOX-15 antibiotic_resistance ARO:3008383 MOX-15 ARO:3008383 MOX-15 CMY-1/MOX family class C beta-lactamase MOX-16. MOX-16 antibiotic_resistance ARO:3008384 MOX-16 ARO:3008384 MOX-16 CMY-1/MOX family class C beta-lactamase MOX-17. MOX-17 antibiotic_resistance ARO:3008385 MOX-17 ARO:3008385 MOX-17 CMY-1/MOX family class C beta-lactamase MOX-18. MOX-18 antibiotic_resistance ARO:3008386 MOX-18 ARO:3008386 MOX-18 CMY-1/MOX family class C beta-lactamase MOX-19. MOX-19 antibiotic_resistance ARO:3008387 MOX-19 ARO:3008387 MOX-19 CMY-1/MOX family class C beta-lactamase MOX-20. MOX-20 antibiotic_resistance ARO:3008388 MOX-20 ARO:3008388 MOX-20 CMY-1/MOX family class C beta-lactamase MOX-21. MOX-21 antibiotic_resistance ARO:3008389 MOX-21 ARO:3008389 MOX-21 CMY-1/MOX family class C beta-lactamase MOX-22. MOX-22 antibiotic_resistance ARO:3008390 MOX-22 ARO:3008390 MOX-22 CMY-1/MOX family class C beta-lactamase MOX-23. MOX-23 antibiotic_resistance ARO:3008391 MOX-23 ARO:3008391 MOX-23 CMY-1/MOX family class C beta-lactamase MOX-24. MOX-24 antibiotic_resistance ARO:3008392 MOX-24 ARO:3008392 MOX-24 CMY-1/MOX family class C beta-lactamase MOX-25. MOX-25 antibiotic_resistance ARO:3008393 MOX-25 ARO:3008393 MOX-25 MUN family extended-spectrum class A beta-lactamase MUN-1. MUN-1 antibiotic_resistance ARO:3008394 MUN-1 ARO:3008394 MUN-1 MUN family extended-spectrum class A beta-lactamase MUN-6. MUN-6 antibiotic_resistance ARO:3008395 MUN-6 ARO:3008395 MUN-6 Subclass B1 metallo-beta-lactamase NDM-48. NDM-48 antibiotic_resistance ARO:3008396 NDM-48 ARO:3008396 NDM-48 Subclass B1 metallo-beta-lactamase NDM-49. NDM-49 antibiotic_resistance ARO:3008397 NDM-49 ARO:3008397 NDM-49 Subclass B1 metallo-beta-lactamase NDM-50. NDM-50 antibiotic_resistance ARO:3008398 NDM-50 ARO:3008398 NDM-50 Subclass B1 metallo-beta-lactamase NDM-51. NDM-51 antibiotic_resistance ARO:3008399 NDM-51 ARO:3008399 NDM-51 Subclass B1 metallo-beta-lactamase NDM-52. NDM-52 antibiotic_resistance ARO:3008400 NDM-52 ARO:3008400 NDM-52 Subclass B1 metallo-beta-lactamase NDM-53. NDM-53 antibiotic_resistance ARO:3008401 NDM-53 ARO:3008401 NDM-53 Subclass B1 metallo-beta-lactamase NDM-54. NDM-54 antibiotic_resistance ARO:3008402 NDM-54 ARO:3008402 NDM-54 Subclass B1 metallo-beta-lactamase NDM-55. NDM-55 antibiotic_resistance ARO:3008403 NDM-55 ARO:3008403 NDM-55 Subclass B1 metallo-beta-lactamase NDM-56. NDM-56 antibiotic_resistance ARO:3008404 NDM-56 ARO:3008404 NDM-56 Subclass B1 metallo-beta-lactamase NDM-57. NDM-57 antibiotic_resistance ARO:3008405 NDM-57 ARO:3008405 NDM-57 Subclass B1 metallo-beta-lactamase NDM-58. NDM-58 antibiotic_resistance ARO:3008406 NDM-58 ARO:3008406 NDM-58 Subclass B1 metallo-beta-lactamase NDM-60. NDM-60 antibiotic_resistance ARO:3008407 NDM-60 ARO:3008407 NDM-60 Subclass B1 metallo-beta-lactamase NDM-61. NDM-61 antibiotic_resistance ARO:3008408 NDM-61 ARO:3008408 NDM-61 Subclass B1 metallo-beta-lactamase NDM-64. NDM-64 antibiotic_resistance ARO:3008409 NDM-64 ARO:3008409 NDM-64 Subclass B1 metallo-beta-lactamase NDM-65. NDM-65 antibiotic_resistance ARO:3008410 NDM-65 ARO:3008410 NDM-65 Subclass B1 metallo-beta-lactamase NDM-66. NDM-66 antibiotic_resistance ARO:3008411 NDM-66 ARO:3008411 NDM-66 Subclass B1 metallo-beta-lactamase NDM-67. NDM-67 antibiotic_resistance ARO:3008412 NDM-67 ARO:3008412 NDM-67 Subclass B1 metallo-beta-lactamase NDM-68. NDM-68 antibiotic_resistance ARO:3008413 NDM-68 ARO:3008413 NDM-68 Subclass B1 metallo-beta-lactamase NDM-69. NDM-69 antibiotic_resistance ARO:3008414 NDM-69 ARO:3008414 NDM-69 Subclass B1 metallo-beta-lactamase NDM-70. NDM-70 antibiotic_resistance ARO:3008415 NDM-70 ARO:3008415 NDM-70 Subclass B1 metallo-beta-lactamase NDM-71. NDM-71 antibiotic_resistance ARO:3008416 NDM-71 ARO:3008416 NDM-71 Subclass B1 metallo-beta-lactamase NDM-72. NDM-72 antibiotic_resistance ARO:3008417 NDM-72 ARO:3008417 NDM-72 Subclass B1 metallo-beta-lactamase NDM-73. NDM-73 antibiotic_resistance ARO:3008418 NDM-73 ARO:3008418 NDM-73 Subclass B1 metallo-beta-lactamase NDM-74. NDM-74 antibiotic_resistance ARO:3008419 NDM-74 ARO:3008419 NDM-74 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1000. OXA-1000 antibiotic_resistance ARO:3008421 OXA-1000 ARO:3008421 OXA-1000 OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-1001. OXA-1001 antibiotic_resistance ARO:3008422 OXA-1001 ARO:3008422 OXA-1001 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1002. OXA-1002 antibiotic_resistance ARO:3008423 OXA-1002 ARO:3008423 OXA-1002 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1003. OXA-1003 antibiotic_resistance ARO:3008424 OXA-1003 ARO:3008424 OXA-1003 OXA-294 family class D beta-lactamase OXA-1004. OXA-1004 antibiotic_resistance ARO:3008425 OXA-1004 ARO:3008425 OXA-1004 OXA-134 family carbapenem-hydrolyzing class D beta-lactamase OXA-1005. OXA-1005 antibiotic_resistance ARO:3008426 OXA-1005 ARO:3008426 OXA-1005 Class D beta-lactamase OXA-1006. OXA-1006 antibiotic_resistance ARO:3008427 OXA-1006 ARO:3008427 OXA-1006 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1007. OXA-1007 antibiotic_resistance ARO:3008428 OXA-1007 ARO:3008428 OXA-1007 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1008. OXA-1008 antibiotic_resistance ARO:3008429 OXA-1008 ARO:3008429 OXA-1008 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1009. OXA-1009 antibiotic_resistance ARO:3008430 OXA-1009 ARO:3008430 OXA-1009 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1010. OXA-1010 antibiotic_resistance ARO:3008431 OXA-1010 ARO:3008431 OXA-1010 Class D beta-lactamase OXA-1011. OXA-1011 antibiotic_resistance ARO:3008432 OXA-1011 ARO:3008432 OXA-1011 OXA-48 family class D beta-lactamase OXA-1012. OXA-1012 antibiotic_resistance ARO:3008433 OXA-1012 ARO:3008433 OXA-1012 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1013. OXA-1013 antibiotic_resistance ARO:3008434 OXA-1013 ARO:3008434 OXA-1013 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1014. OXA-1014 antibiotic_resistance ARO:3008435 OXA-1014 ARO:3008435 OXA-1014 OXA-10 family class D beta-lactamase OXA-1015. OXA-1015 antibiotic_resistance ARO:3008436 OXA-1015 ARO:3008436 OXA-1015 OXA-372 family carbapenem-hydrolyzing class D beta-lactamase OXA-1016. OXA-1016 antibiotic_resistance ARO:3008437 OXA-1016 ARO:3008437 OXA-1016 OXA-2 family class D beta-lactamase OXA-1017. OXA-1017 antibiotic_resistance ARO:3008438 OXA-1017 ARO:3008438 OXA-1017 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1018. OXA-1018 antibiotic_resistance ARO:3008439 OXA-1018 ARO:3008439 OXA-1018 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1019. OXA-1019 antibiotic_resistance ARO:3008440 OXA-1019 ARO:3008440 OXA-1019 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1020. OXA-1020 antibiotic_resistance ARO:3008441 OXA-1020 ARO:3008441 OXA-1020 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1021. OXA-1021 antibiotic_resistance ARO:3008442 OXA-1021 ARO:3008442 OXA-1021 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1022. OXA-1022 antibiotic_resistance ARO:3008443 OXA-1022 ARO:3008443 OXA-1022 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1023. OXA-1023 antibiotic_resistance ARO:3008444 OXA-1023 ARO:3008444 OXA-1023 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1024. OXA-1024 antibiotic_resistance ARO:3008445 OXA-1024 ARO:3008445 OXA-1024 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1025. OXA-1025 antibiotic_resistance ARO:3008446 OXA-1025 ARO:3008446 OXA-1025 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1026. OXA-1026 antibiotic_resistance ARO:3008447 OXA-1026 ARO:3008447 OXA-1026 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1027. OXA-1027 antibiotic_resistance ARO:3008448 OXA-1027 ARO:3008448 OXA-1027 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1028. OXA-1028 antibiotic_resistance ARO:3008449 OXA-1028 ARO:3008449 OXA-1028 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1029. OXA-1029 antibiotic_resistance ARO:3008450 OXA-1029 ARO:3008450 OXA-1029 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1030. OXA-1030 antibiotic_resistance ARO:3008451 OXA-1030 ARO:3008451 OXA-1030 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1031. OXA-1031 antibiotic_resistance ARO:3008452 OXA-1031 ARO:3008452 OXA-1031 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1032. OXA-1032 antibiotic_resistance ARO:3008453 OXA-1032 ARO:3008453 OXA-1032 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1033. OXA-1033 antibiotic_resistance ARO:3008454 OXA-1033 ARO:3008454 OXA-1033 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1034. OXA-1034 antibiotic_resistance ARO:3008455 OXA-1034 ARO:3008455 OXA-1034 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1035. OXA-1035 antibiotic_resistance ARO:3008456 OXA-1035 ARO:3008456 OXA-1035 Carbapenem-hydrolyzing class D beta-lactamase OXA-1036. OXA-1036 antibiotic_resistance ARO:3008457 OXA-1036 ARO:3008457 OXA-1036 Class D beta-lactamase OXA-1037. OXA-1037 antibiotic_resistance ARO:3008458 OXA-1037 ARO:3008458 OXA-1037 OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-1040. OXA-1040 antibiotic_resistance ARO:3008459 OXA-1040 ARO:3008459 OXA-1040 Carbapenem-hydrolyzing class D beta-lactamase OXA-1041. OXA-1041 antibiotic_resistance ARO:3008460 OXA-1041 ARO:3008460 OXA-1041 OXA-1 family class D beta-lactamase OXA-1042. OXA-1042 antibiotic_resistance ARO:3008461 OXA-1042 ARO:3008461 OXA-1042 Class D beta-lactamase OXA-1043. OXA-1043 antibiotic_resistance ARO:3008462 OXA-1043 ARO:3008462 OXA-1043 OXA-211 family carbapenem-hydrolyzing class D beta-lactamase OXA-1044. OXA-1044 antibiotic_resistance ARO:3008463 OXA-1044 ARO:3008463 OXA-1044 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1045. OXA-1045 antibiotic_resistance ARO:3008464 OXA-1045 ARO:3008464 OXA-1045 OXA-10 family class D beta-lactamase OXA-1046. OXA-1046 antibiotic_resistance ARO:3008465 OXA-1046 ARO:3008465 OXA-1046 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1047. OXA-1047 antibiotic_resistance ARO:3008466 OXA-1047 ARO:3008466 OXA-1047 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1048. OXA-1048 antibiotic_resistance ARO:3008467 OXA-1048 ARO:3008467 OXA-1048 OXA-2 family class D beta-lactamase OXA-1049. OXA-1049 antibiotic_resistance ARO:3008468 OXA-1049 ARO:3008468 OXA-1049 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1050. OXA-1050 antibiotic_resistance ARO:3008469 OXA-1050 ARO:3008469 OXA-1050 OXA-679 family carbapenem-hydrolyzing class D beta-lactamase OXA-1051. OXA-1051 antibiotic_resistance ARO:3008470 OXA-1051 ARO:3008470 OXA-1051 OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-1052. OXA-1052 antibiotic_resistance ARO:3008471 OXA-1052 ARO:3008471 OXA-1052 OXA-10 family class D beta-lactamase OXA-1053. OXA-1053 antibiotic_resistance ARO:3008472 OXA-1053 ARO:3008472 OXA-1053 OXA-48 family class D beta-lactamase OXA-1055. OXA-1055 antibiotic_resistance ARO:3008473 OXA-1055 ARO:3008473 OXA-1055 OXA-198 family carbapenem-hydrolyzing class D beta-lactamase OXA-1056. OXA-1056 antibiotic_resistance ARO:3008474 OXA-1056 ARO:3008474 OXA-1056 OXA-198 family carbapenem-hydrolyzing class D beta-lactamase OXA-1057. OXA-1057 antibiotic_resistance ARO:3008475 OXA-1057 ARO:3008475 OXA-1057 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1058. OXA-1058 antibiotic_resistance ARO:3008476 OXA-1058 ARO:3008476 OXA-1058 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1059. OXA-1059 antibiotic_resistance ARO:3008477 OXA-1059 ARO:3008477 OXA-1059 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1060. OXA-1060 antibiotic_resistance ARO:3008478 OXA-1060 ARO:3008478 OXA-1060 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1061. OXA-1061 antibiotic_resistance ARO:3008479 OXA-1061 ARO:3008479 OXA-1061 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1062. OXA-1062 antibiotic_resistance ARO:3008480 OXA-1062 ARO:3008480 OXA-1062 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1063. OXA-1063 antibiotic_resistance ARO:3008481 OXA-1063 ARO:3008481 OXA-1063 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1064. OXA-1064 antibiotic_resistance ARO:3008482 OXA-1064 ARO:3008482 OXA-1064 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1065. OXA-1065 antibiotic_resistance ARO:3008483 OXA-1065 ARO:3008483 OXA-1065 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1066. OXA-1066 antibiotic_resistance ARO:3008484 OXA-1066 ARO:3008484 OXA-1066 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1067. OXA-1067 antibiotic_resistance ARO:3008485 OXA-1067 ARO:3008485 OXA-1067 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1068. OXA-1068 antibiotic_resistance ARO:3008486 OXA-1068 ARO:3008486 OXA-1068 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1069. OXA-1069 antibiotic_resistance ARO:3008487 OXA-1069 ARO:3008487 OXA-1069 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1070. OXA-1070 antibiotic_resistance ARO:3008488 OXA-1070 ARO:3008488 OXA-1070 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1071. OXA-1071 antibiotic_resistance ARO:3008489 OXA-1071 ARO:3008489 OXA-1071 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1072. OXA-1072 antibiotic_resistance ARO:3008490 OXA-1072 ARO:3008490 OXA-1072 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1073. OXA-1073 antibiotic_resistance ARO:3008491 OXA-1073 ARO:3008491 OXA-1073 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1074. OXA-1074 antibiotic_resistance ARO:3008492 OXA-1074 ARO:3008492 OXA-1074 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1075. OXA-1075 antibiotic_resistance ARO:3008493 OXA-1075 ARO:3008493 OXA-1075 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1076. OXA-1076 antibiotic_resistance ARO:3008494 OXA-1076 ARO:3008494 OXA-1076 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1077. OXA-1077 antibiotic_resistance ARO:3008495 OXA-1077 ARO:3008495 OXA-1077 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1078. OXA-1078 antibiotic_resistance ARO:3008496 OXA-1078 ARO:3008496 OXA-1078 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1079. OXA-1079 antibiotic_resistance ARO:3008497 OXA-1079 ARO:3008497 OXA-1079 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1080. OXA-1080 antibiotic_resistance ARO:3008498 OXA-1080 ARO:3008498 OXA-1080 OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-1081. OXA-1081 antibiotic_resistance ARO:3008499 OXA-1081 ARO:3008499 OXA-1081 OXA-2 family class D beta-lactamase OXA-1082. OXA-1082 antibiotic_resistance ARO:3008500 OXA-1082 ARO:3008500 OXA-1082 OXA-2 family class D beta-lactamase OXA-1083. OXA-1083 antibiotic_resistance ARO:3008501 OXA-1083 ARO:3008501 OXA-1083 OXA-2 family class D beta-lactamase OXA-1084. OXA-1084 antibiotic_resistance ARO:3008502 OXA-1084 ARO:3008502 OXA-1084 OXA-2 family class D beta-lactamase OXA-1085. OXA-1085 antibiotic_resistance ARO:3008503 OXA-1085 ARO:3008503 OXA-1085 OXA-10 family class D beta-lactamase OXA-1086. OXA-1086 antibiotic_resistance ARO:3008504 OXA-1086 ARO:3008504 OXA-1086 OXA-10 family class D beta-lactamase OXA-1087. OXA-1087 antibiotic_resistance ARO:3008505 OXA-1087 ARO:3008505 OXA-1087 OXA-10 family class D beta-lactamase OXA-1088. OXA-1088 antibiotic_resistance ARO:3008506 OXA-1088 ARO:3008506 OXA-1088 Carbapenem-hydrolyzing class D beta-lactamase OXA-1089. OXA-1089 antibiotic_resistance ARO:3008507 OXA-1089 ARO:3008507 OXA-1089 Carbapenem-hydrolyzing class D beta-lactamase OXA-1090. OXA-1090 antibiotic_resistance ARO:3008508 OXA-1090 ARO:3008508 OXA-1090 Oxacillin-hydrolyzing class D beta-lactamase OXA-1091. OXA-1091 antibiotic_resistance ARO:3008509 OXA-1091 ARO:3008509 OXA-1091 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1092. OXA-1092 antibiotic_resistance ARO:3008510 OXA-1092 ARO:3008510 OXA-1092 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1093. OXA-1093 antibiotic_resistance ARO:3008511 OXA-1093 ARO:3008511 OXA-1093 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1094. OXA-1094 antibiotic_resistance ARO:3008512 OXA-1094 ARO:3008512 OXA-1094 OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-1095. OXA-1095 antibiotic_resistance ARO:3008513 OXA-1095 ARO:3008513 OXA-1095 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1096. OXA-1096 antibiotic_resistance ARO:3008514 OXA-1096 ARO:3008514 OXA-1096 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1097. OXA-1097 antibiotic_resistance ARO:3008515 OXA-1097 ARO:3008515 OXA-1097 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1098. OXA-1098 antibiotic_resistance ARO:3008516 OXA-1098 ARO:3008516 OXA-1098 OXA-63 family oxacillin-hydrolyzing class D beta-lactamase OXA-1099. OXA-1099 antibiotic_resistance ARO:3008517 OXA-1099 ARO:3008517 OXA-1099 OXA-63 family oxacillin-hydrolyzing class D beta-lactamase OXA-1100. OXA-1100 antibiotic_resistance ARO:3008518 OXA-1100 ARO:3008518 OXA-1100 OXA-63 family oxacillin-hydrolyzing class D beta-lactamase OXA-1101. OXA-1101 antibiotic_resistance ARO:3008519 OXA-1101 ARO:3008519 OXA-1101 OXA-63 family oxacillin-hydrolyzing class D beta-lactamase OXA-1102. OXA-1102 antibiotic_resistance ARO:3008520 OXA-1102 ARO:3008520 OXA-1102 OXA-63 family oxacillin-hydrolyzing class D beta-lactamase OXA-1103. OXA-1103 antibiotic_resistance ARO:3008521 OXA-1103 ARO:3008521 OXA-1103 OXA-63 family oxacillin-hydrolyzing class D beta-lactamase OXA-1104. OXA-1104 antibiotic_resistance ARO:3008522 OXA-1104 ARO:3008522 OXA-1104 OXA-63 family oxacillin-hydrolyzing class D beta-lactamase OXA-1105. OXA-1105 antibiotic_resistance ARO:3008523 OXA-1105 ARO:3008523 OXA-1105 OXA-63 family oxacillin-hydrolyzing class D beta-lactamase OXA-1106. OXA-1106 antibiotic_resistance ARO:3008524 OXA-1106 ARO:3008524 OXA-1106 OXA-63 family oxacillin-hydrolyzing class D beta-lactamase OXA-1107. OXA-1107 antibiotic_resistance ARO:3008525 OXA-1107 ARO:3008525 OXA-1107 Class D beta-lactamase OXA-1108. OXA-1108 antibiotic_resistance ARO:3008526 OXA-1108 ARO:3008526 OXA-1108 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1109. OXA-1109 antibiotic_resistance ARO:3008527 OXA-1109 ARO:3008527 OXA-1109 OXA-134 family carbapenem-hydrolyzing class D beta-lactamase OXA-1110. OXA-1110 antibiotic_resistance ARO:3008528 OXA-1110 ARO:3008528 OXA-1110 OXA-134 family carbapenem-hydrolyzing class D beta-lactamase OXA-1111. OXA-1111 antibiotic_resistance ARO:3008529 OXA-1111 ARO:3008529 OXA-1111 OXA-134 family carbapenem-hydrolyzing class D beta-lactamase OXA-1112. OXA-1112 antibiotic_resistance ARO:3008530 OXA-1112 ARO:3008530 OXA-1112 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1113. OXA-1113 antibiotic_resistance ARO:3008531 OXA-1113 ARO:3008531 OXA-1113 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1114. OXA-1114 antibiotic_resistance ARO:3008532 OXA-1114 ARO:3008532 OXA-1114 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1115. OXA-1115 antibiotic_resistance ARO:3008533 OXA-1115 ARO:3008533 OXA-1115 OXA-134 family carbapenem-hydrolyzing class D beta-lactamase OXA-1116. OXA-1116 antibiotic_resistance ARO:3008534 OXA-1116 ARO:3008534 OXA-1116 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1117. OXA-1117 antibiotic_resistance ARO:3008535 OXA-1117 ARO:3008535 OXA-1117 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1118. OXA-1118 antibiotic_resistance ARO:3008536 OXA-1118 ARO:3008536 OXA-1118 OXA-48 family class D beta-lactamase OXA-1119. OXA-1119 antibiotic_resistance ARO:3008537 OXA-1119 ARO:3008537 OXA-1119 OXA-10 family class D beta-lactamase OXA-1120. OXA-1120 antibiotic_resistance ARO:3008538 OXA-1120 ARO:3008538 OXA-1120 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1121. OXA-1121 antibiotic_resistance ARO:3008539 OXA-1121 ARO:3008539 OXA-1121 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1122. OXA-1122 antibiotic_resistance ARO:3008540 OXA-1122 ARO:3008540 OXA-1122 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1123. OXA-1123 antibiotic_resistance ARO:3008541 OXA-1123 ARO:3008541 OXA-1123 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1124. OXA-1124 antibiotic_resistance ARO:3008542 OXA-1124 ARO:3008542 OXA-1124 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1125. OXA-1125 antibiotic_resistance ARO:3008543 OXA-1125 ARO:3008543 OXA-1125 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1126. OXA-1126 antibiotic_resistance ARO:3008544 OXA-1126 ARO:3008544 OXA-1126 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1127. OXA-1127 antibiotic_resistance ARO:3008545 OXA-1127 ARO:3008545 OXA-1127 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1128. OXA-1128 antibiotic_resistance ARO:3008546 OXA-1128 ARO:3008546 OXA-1128 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1129. OXA-1129 antibiotic_resistance ARO:3008547 OXA-1129 ARO:3008547 OXA-1129 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1130. OXA-1130 antibiotic_resistance ARO:3008548 OXA-1130 ARO:3008548 OXA-1130 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1131. OXA-1131 antibiotic_resistance ARO:3008549 OXA-1131 ARO:3008549 OXA-1131 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1132. OXA-1132 antibiotic_resistance ARO:3008550 OXA-1132 ARO:3008550 OXA-1132 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1133. OXA-1133 antibiotic_resistance ARO:3008551 OXA-1133 ARO:3008551 OXA-1133 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1134. OXA-1134 antibiotic_resistance ARO:3008552 OXA-1134 ARO:3008552 OXA-1134 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1135. OXA-1135 antibiotic_resistance ARO:3008553 OXA-1135 ARO:3008553 OXA-1135 OXA-2 family class D beta-lactamase OXA-1136. OXA-1136 antibiotic_resistance ARO:3008554 OXA-1136 ARO:3008554 OXA-1136 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1137. OXA-1137 antibiotic_resistance ARO:3008555 OXA-1137 ARO:3008555 OXA-1137 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1138. OXA-1138 antibiotic_resistance ARO:3008556 OXA-1138 ARO:3008556 OXA-1138 OXA-143 family carbapenem-hydrolyzing class D beta-lactamase OXA-1139. OXA-1139 antibiotic_resistance ARO:3008557 OXA-1139 ARO:3008557 OXA-1139 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1140. OXA-1140 antibiotic_resistance ARO:3008558 OXA-1140 ARO:3008558 OXA-1140 OXA-10 family class D beta-lactamase OXA-1141. OXA-1141 antibiotic_resistance ARO:3008559 OXA-1141 ARO:3008559 OXA-1141 Class D beta-lactamase OXA-1142. OXA-1142 antibiotic_resistance ARO:3008560 OXA-1142 ARO:3008560 OXA-1142 Class D beta-lactamase OXA-1143. OXA-1143 antibiotic_resistance ARO:3008561 OXA-1143 ARO:3008561 OXA-1143 OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-1144. OXA-1144 antibiotic_resistance ARO:3008562 OXA-1144 ARO:3008562 OXA-1144 OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-1145. OXA-1145 antibiotic_resistance ARO:3008563 OXA-1145 ARO:3008563 OXA-1145 OXA-48 family class D beta-lactamase OXA-1146. OXA-1146 antibiotic_resistance ARO:3008564 OXA-1146 ARO:3008564 OXA-1146 OXA-10 family class D beta-lactamase OXA-1147. OXA-1147 antibiotic_resistance ARO:3008565 OXA-1147 ARO:3008565 OXA-1147 OXA-10 family class D beta-lactamase OXA-1148. OXA-1148 antibiotic_resistance ARO:3008566 OXA-1148 ARO:3008566 OXA-1148 OXA-62 family carbapenem-hydrolyzing class D beta-lactamase OXA-1149. OXA-1149 antibiotic_resistance ARO:3008567 OXA-1149 ARO:3008567 OXA-1149 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1150. OXA-1150 antibiotic_resistance ARO:3008568 OXA-1150 ARO:3008568 OXA-1150 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1151. OXA-1151 antibiotic_resistance ARO:3008569 OXA-1151 ARO:3008569 OXA-1151 OXA-62 family carbapenem-hydrolyzing class D beta-lactamase OXA-1152. OXA-1152 antibiotic_resistance ARO:3008570 OXA-1152 ARO:3008570 OXA-1152 Class D beta-lactamase OXA-1153. OXA-1153 antibiotic_resistance ARO:3008571 OXA-1153 ARO:3008571 OXA-1153 Class D beta-lactamase OXA-1154. OXA-1154 antibiotic_resistance ARO:3008572 OXA-1154 ARO:3008572 OXA-1154 Class D beta-lactamase OXA-1155. OXA-1155 antibiotic_resistance ARO:3008573 OXA-1155 ARO:3008573 OXA-1155 Class D beta-lactamase OXA-1156. OXA-1156 antibiotic_resistance ARO:3008574 OXA-1156 ARO:3008574 OXA-1156 OXA-12 family class D beta-lactamase OXA-1157. OXA-1157 antibiotic_resistance ARO:3008575 OXA-1157 ARO:3008575 OXA-1157 Class D beta-lactamase OXA-1158. OXA-1158 antibiotic_resistance ARO:3008576 OXA-1158 ARO:3008576 OXA-1158 Class D beta-lactamase OXA-1159. OXA-1159 antibiotic_resistance ARO:3008577 OXA-1159 ARO:3008577 OXA-1159 Class D beta-lactamase OXA-1160. OXA-1160 antibiotic_resistance ARO:3008578 OXA-1160 ARO:3008578 OXA-1160 Class D beta-lactamase OXA-1161. OXA-1161 antibiotic_resistance ARO:3008579 OXA-1161 ARO:3008579 OXA-1161 OXA-12 family class D beta-lactamase OXA-1162. OXA-1162 antibiotic_resistance ARO:3008580 OXA-1162 ARO:3008580 OXA-1162 Class D beta-lactamase OXA-1163. OXA-1163 antibiotic_resistance ARO:3008581 OXA-1163 ARO:3008581 OXA-1163 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1164. OXA-1164 antibiotic_resistance ARO:3008582 OXA-1164 ARO:3008582 OXA-1164 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1165. OXA-1165 antibiotic_resistance ARO:3008583 OXA-1165 ARO:3008583 OXA-1165 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1166. OXA-1166 antibiotic_resistance ARO:3008584 OXA-1166 ARO:3008584 OXA-1166 OXA-48 family class D beta-lactamase OXA-1167. OXA-1167 antibiotic_resistance ARO:3008585 OXA-1167 ARO:3008585 OXA-1167 OXA-10 family class D beta-lactamase OXA-1168. OXA-1168 antibiotic_resistance ARO:3008586 OXA-1168 ARO:3008586 OXA-1168 OXA-10 family class D beta-lactamase OXA-1169. OXA-1169 antibiotic_resistance ARO:3008587 OXA-1169 ARO:3008587 OXA-1169 OXA-10 family class D beta-lactamase OXA-1170. OXA-1170 antibiotic_resistance ARO:3008588 OXA-1170 ARO:3008588 OXA-1170 OXA-10 family class D beta-lactamase OXA-1171. OXA-1171 antibiotic_resistance ARO:3008589 OXA-1171 ARO:3008589 OXA-1171 OXA-2 family class D beta-lactamase OXA-1172. OXA-1172 antibiotic_resistance ARO:3008590 OXA-1172 ARO:3008590 OXA-1172 OXA-2 family class D beta-lactamase OXA-1173. OXA-1173 antibiotic_resistance ARO:3008591 OXA-1173 ARO:3008591 OXA-1173 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1174. OXA-1174 antibiotic_resistance ARO:3008592 OXA-1174 ARO:3008592 OXA-1174 OXA-10 family class D beta-lactamase OXA-1175. OXA-1175 antibiotic_resistance ARO:3008593 OXA-1175 ARO:3008593 OXA-1175 OXA-60 family carbapenem-hydrolyzing class D beta-lactamase OXA-1176. OXA-1176 antibiotic_resistance ARO:3008594 OXA-1176 ARO:3008594 OXA-1176 OXA-22 family class D beta-lactamase OXA-1177. OXA-1177 antibiotic_resistance ARO:3008595 OXA-1177 ARO:3008595 OXA-1177 OXA-58 family carbapenem-hydrolyzing class D beta-lactamase OXA-1178. OXA-1178 antibiotic_resistance ARO:3008596 OXA-1178 ARO:3008596 OXA-1178 OXA-48 family class D beta-lactamase OXA-1181. OXA-1181 antibiotic_resistance ARO:3008597 OXA-1181 ARO:3008597 OXA-1181 OXA-143 family carbapenem-hydrolyzing class D beta-lactamase OXA-1182. OXA-1182 antibiotic_resistance ARO:3008598 OXA-1182 ARO:3008598 OXA-1182 OXA-2 family class D beta-lactamase OXA-1183. OXA-1183 antibiotic_resistance ARO:3008599 OXA-1183 ARO:3008599 OXA-1183 OXA-10 family class D beta-lactamase OXA-1184. OXA-1184 antibiotic_resistance ARO:3008600 OXA-1184 ARO:3008600 OXA-1184 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1185. OXA-1185 antibiotic_resistance ARO:3008601 OXA-1185 ARO:3008601 OXA-1185 OXA-198 family carbapenem-hydrolyzing class D beta-lactamase OXA-1186. OXA-1186 antibiotic_resistance ARO:3008602 OXA-1186 ARO:3008602 OXA-1186 OXA-2 family class D beta-lactamase OXA-1187. OXA-1187 antibiotic_resistance ARO:3008603 OXA-1187 ARO:3008603 OXA-1187 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1188. OXA-1188 antibiotic_resistance ARO:3008604 OXA-1188 ARO:3008604 OXA-1188 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1189. OXA-1189 antibiotic_resistance ARO:3008605 OXA-1189 ARO:3008605 OXA-1189 OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-1190. OXA-1190 antibiotic_resistance ARO:3008606 OXA-1190 ARO:3008606 OXA-1190 OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-1191. OXA-1191 antibiotic_resistance ARO:3008607 OXA-1191 ARO:3008607 OXA-1191 OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-1193. OXA-1193 antibiotic_resistance ARO:3008608 OXA-1193 ARO:3008608 OXA-1193 OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-1194. OXA-1194 antibiotic_resistance ARO:3008609 OXA-1194 ARO:3008609 OXA-1194 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1198. OXA-1198 antibiotic_resistance ARO:3008610 OXA-1198 ARO:3008610 OXA-1198 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1199. OXA-1199 antibiotic_resistance ARO:3008611 OXA-1199 ARO:3008611 OXA-1199 OXA-48 family class D beta-lactamase OXA-1200. OXA-1200 antibiotic_resistance ARO:3008612 OXA-1200 ARO:3008612 OXA-1200 OXA-48 family class D beta-lactamase OXA-1201. OXA-1201 antibiotic_resistance ARO:3008613 OXA-1201 ARO:3008613 OXA-1201 OXA-10 family class D beta-lactamase OXA-1202. OXA-1202 antibiotic_resistance ARO:3008614 OXA-1202 ARO:3008614 OXA-1202 OXA-10 family class D beta-lactamase OXA-1203. OXA-1203 antibiotic_resistance ARO:3008615 OXA-1203 ARO:3008615 OXA-1203 OXA-10 family class D beta-lactamase OXA-1204. OXA-1204 antibiotic_resistance ARO:3008616 OXA-1204 ARO:3008616 OXA-1204 OXA-48 family class D beta-lactamase OXA-1205. OXA-1205 antibiotic_resistance ARO:3008617 OXA-1205 ARO:3008617 OXA-1205 Class D beta-lactamase OXA-1206. OXA-1206 antibiotic_resistance ARO:3008618 OXA-1206 ARO:3008618 OXA-1206 OXA-48 family class D beta-lactamase OXA-1207. OXA-1207 antibiotic_resistance ARO:3008619 OXA-1207 ARO:3008619 OXA-1207 OXA-211 family carbapenem-hydrolyzing class D beta-lactamase OXA-1208. OXA-1208 antibiotic_resistance ARO:3008620 OXA-1208 ARO:3008620 OXA-1208 OXA-48 family class D beta-lactamase OXA-1211. OXA-1211 antibiotic_resistance ARO:3008621 OXA-1211 ARO:3008621 OXA-1211 OXA-48 family class D beta-lactamase OXA-1212. OXA-1212 antibiotic_resistance ARO:3008622 OXA-1212 ARO:3008622 OXA-1212 OXA-48 family class D beta-lactamase OXA-1213. OXA-1213 antibiotic_resistance ARO:3008623 OXA-1213 ARO:3008623 OXA-1213 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1214. OXA-1214 antibiotic_resistance ARO:3008624 OXA-1214 ARO:3008624 OXA-1214 OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-1215. OXA-1215 antibiotic_resistance ARO:3008625 OXA-1215 ARO:3008625 OXA-1215 OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-1216. OXA-1216 antibiotic_resistance ARO:3008626 OXA-1216 ARO:3008626 OXA-1216 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1217. OXA-1217 antibiotic_resistance ARO:3008627 OXA-1217 ARO:3008627 OXA-1217 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1218. OXA-1218 antibiotic_resistance ARO:3008628 OXA-1218 ARO:3008628 OXA-1218 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1219. OXA-1219 antibiotic_resistance ARO:3008629 OXA-1219 ARO:3008629 OXA-1219 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1220. OXA-1220 antibiotic_resistance ARO:3008630 OXA-1220 ARO:3008630 OXA-1220 OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-1221. OXA-1221 antibiotic_resistance ARO:3008631 OXA-1221 ARO:3008631 OXA-1221 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1222. OXA-1222 antibiotic_resistance ARO:3008632 OXA-1222 ARO:3008632 OXA-1222 OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-1223. OXA-1223 antibiotic_resistance ARO:3008633 OXA-1223 ARO:3008633 OXA-1223 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1224. OXA-1224 antibiotic_resistance ARO:3008634 OXA-1224 ARO:3008634 OXA-1224 OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-1225. OXA-1225 antibiotic_resistance ARO:3008635 OXA-1225 ARO:3008635 OXA-1225 OXA-48 family class D beta-lactamase OXA-1226. OXA-1226 antibiotic_resistance ARO:3008636 OXA-1226 ARO:3008636 OXA-1226 OXA-62 family carbapenem-hydrolyzing class D beta-lactamase OXA-1227. OXA-1227 antibiotic_resistance ARO:3008637 OXA-1227 ARO:3008637 OXA-1227 OXA-62 family carbapenem-hydrolyzing class D beta-lactamase OXA-1228. OXA-1228 antibiotic_resistance ARO:3008638 OXA-1228 ARO:3008638 OXA-1228 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1229. OXA-1229 antibiotic_resistance ARO:3008639 OXA-1229 ARO:3008639 OXA-1229 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1230. OXA-1230 antibiotic_resistance ARO:3008640 OXA-1230 ARO:3008640 OXA-1230 OXA-10 family class D beta-lactamase OXA-1231. OXA-1231 antibiotic_resistance ARO:3008641 OXA-1231 ARO:3008641 OXA-1231 OXA-10 family class D beta-lactamase OXA-1232. OXA-1232 antibiotic_resistance ARO:3008642 OXA-1232 ARO:3008642 OXA-1232 OXA-10 family class D beta-lactamase OXA-1233. OXA-1233 antibiotic_resistance ARO:3008643 OXA-1233 ARO:3008643 OXA-1233 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1234. OXA-1234 antibiotic_resistance ARO:3008644 OXA-1234 ARO:3008644 OXA-1234 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1235. OXA-1235 antibiotic_resistance ARO:3008645 OXA-1235 ARO:3008645 OXA-1235 OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-1236. OXA-1236 antibiotic_resistance ARO:3008646 OXA-1236 ARO:3008646 OXA-1236 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1237. OXA-1237 antibiotic_resistance ARO:3008647 OXA-1237 ARO:3008647 OXA-1237 Class D beta-lactamase OXA-1238. OXA-1238 antibiotic_resistance ARO:3008648 OXA-1238 ARO:3008648 OXA-1238 Carbapenem-hydrolyzing class D beta-lactamase OXA-1239. OXA-1239 antibiotic_resistance ARO:3008649 OXA-1239 ARO:3008649 OXA-1239 OXA-48 family class D beta-lactamase OXA-1240. OXA-1240 antibiotic_resistance ARO:3008650 OXA-1240 ARO:3008650 OXA-1240 OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-1241. OXA-1241 antibiotic_resistance ARO:3008651 OXA-1241 ARO:3008651 OXA-1241 OXA-48 family class D beta-lactamase OXA-1242. OXA-1242 antibiotic_resistance ARO:3008652 OXA-1242 ARO:3008652 OXA-1242 OXA-2 family class D beta-lactamase OXA-1243. OXA-1243 antibiotic_resistance ARO:3008653 OXA-1243 ARO:3008653 OXA-1243 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1244. OXA-1244 antibiotic_resistance ARO:3008654 OXA-1244 ARO:3008654 OXA-1244 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1245. OXA-1245 antibiotic_resistance ARO:3008655 OXA-1245 ARO:3008655 OXA-1245 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1246. OXA-1246 antibiotic_resistance ARO:3008656 OXA-1246 ARO:3008656 OXA-1246 OXA-10 family class D beta-lactamase OXA-1247. OXA-1247 antibiotic_resistance ARO:3008657 OXA-1247 ARO:3008657 OXA-1247 OXA-10 family class D beta-lactamase OXA-1248. OXA-1248 antibiotic_resistance ARO:3008658 OXA-1248 ARO:3008658 OXA-1248 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1249. OXA-1249 antibiotic_resistance ARO:3008659 OXA-1249 ARO:3008659 OXA-1249 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1250. OXA-1250 antibiotic_resistance ARO:3008660 OXA-1250 ARO:3008660 OXA-1250 OXA-258 family class D beta-lactamase OXA-1251. OXA-1251 antibiotic_resistance ARO:3008661 OXA-1251 ARO:3008661 OXA-1251 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1252. OXA-1252 antibiotic_resistance ARO:3008662 OXA-1252 ARO:3008662 OXA-1252 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1253. OXA-1253 antibiotic_resistance ARO:3008663 OXA-1253 ARO:3008663 OXA-1253 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1254. OXA-1254 antibiotic_resistance ARO:3008664 OXA-1254 ARO:3008664 OXA-1254 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1255. OXA-1255 antibiotic_resistance ARO:3008665 OXA-1255 ARO:3008665 OXA-1255 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1256. OXA-1256 antibiotic_resistance ARO:3008666 OXA-1256 ARO:3008666 OXA-1256 OXA-10 family class D beta-lactamase OXA-1257. OXA-1257 antibiotic_resistance ARO:3008667 OXA-1257 ARO:3008667 OXA-1257 Class D beta-lactamase OXA-1258. OXA-1258 antibiotic_resistance ARO:3008668 OXA-1258 ARO:3008668 OXA-1258 OXA-1258 family class D beta-lactamase OXA-1259. OXA-1259 antibiotic_resistance ARO:3008669 OXA-1259 ARO:3008669 OXA-1259 OXA-1258 family class D beta-lactamase OXA-1260. OXA-1260 antibiotic_resistance ARO:3008670 OXA-1260 ARO:3008670 OXA-1260 OXA-1258 family class D beta-lactamase OXA-1261. OXA-1261 antibiotic_resistance ARO:3008671 OXA-1261 ARO:3008671 OXA-1261 OXA-1258 family class D beta-lactamase OXA-1262. OXA-1262 antibiotic_resistance ARO:3008672 OXA-1262 ARO:3008672 OXA-1262 OXA-1258 family class D beta-lactamase OXA-1263. OXA-1263 antibiotic_resistance ARO:3008673 OXA-1263 ARO:3008673 OXA-1263 OXA-62 family carbapenem-hydrolyzing class D beta-lactamase OXA-1264. OXA-1264 antibiotic_resistance ARO:3008674 OXA-1264 ARO:3008674 OXA-1264 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1265. OXA-1265 antibiotic_resistance ARO:3008675 OXA-1265 ARO:3008675 OXA-1265 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1266. OXA-1266 antibiotic_resistance ARO:3008676 OXA-1266 ARO:3008676 OXA-1266 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1267. OXA-1267 antibiotic_resistance ARO:3008677 OXA-1267 ARO:3008677 OXA-1267 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1268. OXA-1268 antibiotic_resistance ARO:3008678 OXA-1268 ARO:3008678 OXA-1268 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1269. OXA-1269 antibiotic_resistance ARO:3008679 OXA-1269 ARO:3008679 OXA-1269 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1270. OXA-1270 antibiotic_resistance ARO:3008680 OXA-1270 ARO:3008680 OXA-1270 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1271. OXA-1271 antibiotic_resistance ARO:3008681 OXA-1271 ARO:3008681 OXA-1271 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1272. OXA-1272 antibiotic_resistance ARO:3008682 OXA-1272 ARO:3008682 OXA-1272 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1273. OXA-1273 antibiotic_resistance ARO:3008683 OXA-1273 ARO:3008683 OXA-1273 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1274. OXA-1274 antibiotic_resistance ARO:3008684 OXA-1274 ARO:3008684 OXA-1274 OXA-50-var family class D beta-lactamase OXA-1275. OXA-1275 antibiotic_resistance ARO:3008685 OXA-1275 ARO:3008685 OXA-1275 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1276. OXA-1276 antibiotic_resistance ARO:3008686 OXA-1276 ARO:3008686 OXA-1276 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1277. OXA-1277 antibiotic_resistance ARO:3008687 OXA-1277 ARO:3008687 OXA-1277 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1278. OXA-1278 antibiotic_resistance ARO:3008688 OXA-1278 ARO:3008688 OXA-1278 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1279. OXA-1279 antibiotic_resistance ARO:3008689 OXA-1279 ARO:3008689 OXA-1279 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1280. OXA-1280 antibiotic_resistance ARO:3008690 OXA-1280 ARO:3008690 OXA-1280 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1281. OXA-1281 antibiotic_resistance ARO:3008691 OXA-1281 ARO:3008691 OXA-1281 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1282. OXA-1282 antibiotic_resistance ARO:3008692 OXA-1282 ARO:3008692 OXA-1282 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1283. OXA-1283 antibiotic_resistance ARO:3008693 OXA-1283 ARO:3008693 OXA-1283 OXA-50-var family class D beta-lactamase OXA-1284. OXA-1284 antibiotic_resistance ARO:3008694 OXA-1284 ARO:3008694 OXA-1284 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1285. OXA-1285 antibiotic_resistance ARO:3008695 OXA-1285 ARO:3008695 OXA-1285 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1286. OXA-1286 antibiotic_resistance ARO:3008696 OXA-1286 ARO:3008696 OXA-1286 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1287. OXA-1287 antibiotic_resistance ARO:3008697 OXA-1287 ARO:3008697 OXA-1287 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1288. OXA-1288 antibiotic_resistance ARO:3008698 OXA-1288 ARO:3008698 OXA-1288 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1289. OXA-1289 antibiotic_resistance ARO:3008699 OXA-1289 ARO:3008699 OXA-1289 OXA-50-var family class D beta-lactamase OXA-1290. OXA-1290 antibiotic_resistance ARO:3008700 OXA-1290 ARO:3008700 OXA-1290 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1291. OXA-1291 antibiotic_resistance ARO:3008701 OXA-1291 ARO:3008701 OXA-1291 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1292. OXA-1292 antibiotic_resistance ARO:3008702 OXA-1292 ARO:3008702 OXA-1292 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1293. OXA-1293 antibiotic_resistance ARO:3008703 OXA-1293 ARO:3008703 OXA-1293 OXA-50-var family class D beta-lactamase OXA-1294. OXA-1294 antibiotic_resistance ARO:3008704 OXA-1294 ARO:3008704 OXA-1294 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1295. OXA-1295 antibiotic_resistance ARO:3008705 OXA-1295 ARO:3008705 OXA-1295 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1296. OXA-1296 antibiotic_resistance ARO:3008706 OXA-1296 ARO:3008706 OXA-1296 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1297. OXA-1297 antibiotic_resistance ARO:3008707 OXA-1297 ARO:3008707 OXA-1297 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1298. OXA-1298 antibiotic_resistance ARO:3008708 OXA-1298 ARO:3008708 OXA-1298 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1299. OXA-1299 antibiotic_resistance ARO:3008709 OXA-1299 ARO:3008709 OXA-1299 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1300. OXA-1300 antibiotic_resistance ARO:3008710 OXA-1300 ARO:3008710 OXA-1300 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1301. OXA-1301 antibiotic_resistance ARO:3008711 OXA-1301 ARO:3008711 OXA-1301 OXA-10 family class D beta-lactamase OXA-1302. OXA-1302 antibiotic_resistance ARO:3008712 OXA-1302 ARO:3008712 OXA-1302 OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-1303. OXA-1303 antibiotic_resistance ARO:3008713 OXA-1303 ARO:3008713 OXA-1303 OXA-48 family class D beta-lactamase OXA-1304. OXA-1304 antibiotic_resistance ARO:3008714 OXA-1304 ARO:3008714 OXA-1304 OXA-48 family class D beta-lactamase OXA-1305. OXA-1305 antibiotic_resistance ARO:3008715 OXA-1305 ARO:3008715 OXA-1305 OXA-48 family class D beta-lactamase OXA-1306. OXA-1306 antibiotic_resistance ARO:3008716 OXA-1306 ARO:3008716 OXA-1306 OXA-48 family class D beta-lactamase OXA-1307. OXA-1307 antibiotic_resistance ARO:3008717 OXA-1307 ARO:3008717 OXA-1307 OXA-48 family class D beta-lactamase OXA-1308. OXA-1308 antibiotic_resistance ARO:3008718 OXA-1308 ARO:3008718 OXA-1308 OXA-48 family class D beta-lactamase OXA-1309. OXA-1309 antibiotic_resistance ARO:3008719 OXA-1309 ARO:3008719 OXA-1309 OXA-12 family class D beta-lactamase AmpS/OXA-725. OXA-725 antibiotic_resistance ARO:3008720 OXA-725 ARO:3008720 OXA-725 OXA-114 family class D beta-lactamase OXA-790. OXA-790 antibiotic_resistance ARO:3008721 OXA-790 ARO:3008721 OXA-790 OXA-114 family class D beta-lactamase OXA-791. OXA-791 antibiotic_resistance ARO:3008722 OXA-791 ARO:3008722 OXA-791 OXA-48 family class D beta-lactamase OXA-933. OXA-933 antibiotic_resistance ARO:3008723 OXA-933 ARO:3008723 OXA-933 OXA-48 family class D beta-lactamase OXA-934. OXA-934 antibiotic_resistance ARO:3008724 OXA-934 ARO:3008724 OXA-934 OXA-214 family carbapenem-hydrolyzing class D beta-lactamase OXA-936. OXA-936 antibiotic_resistance ARO:3008725 OXA-936 ARO:3008725 OXA-936 OXA-274 family carbapenem-hydrolyzing class D beta-lactamase OXA-944. OXA-944 antibiotic_resistance ARO:3008726 OXA-944 ARO:3008726 OXA-944 OXA-12 family class D beta-lactamase OXA-950. OXA-950 antibiotic_resistance ARO:3008727 OXA-950 ARO:3008727 OXA-950 OXA-12 family class D beta-lactamase OXA-951. OXA-951 antibiotic_resistance ARO:3008728 OXA-951 ARO:3008728 OXA-951 OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-952. OXA-952 antibiotic_resistance ARO:3008729 OXA-952 ARO:3008729 OXA-952 OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-953. OXA-953 antibiotic_resistance ARO:3008730 OXA-953 ARO:3008730 OXA-953 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-954. OXA-954 antibiotic_resistance ARO:3008731 OXA-954 ARO:3008731 OXA-954 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-955. OXA-955 antibiotic_resistance ARO:3008732 OXA-955 ARO:3008732 OXA-955 Class D beta-lactamase OXA-956. OXA-956 antibiotic_resistance ARO:3008733 OXA-956 ARO:3008733 OXA-956 Class D beta-lactamase OXA-957. OXA-957 antibiotic_resistance ARO:3008734 OXA-957 ARO:3008734 OXA-957 OXA-12 family class D beta-lactamase OXA-958. OXA-958 antibiotic_resistance ARO:3008735 OXA-958 ARO:3008735 OXA-958 OXA-12 family class D beta-lactamase OXA-959. OXA-959 antibiotic_resistance ARO:3008736 OXA-959 ARO:3008736 OXA-959 OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-960. OXA-960 antibiotic_resistance ARO:3008737 OXA-960 ARO:3008737 OXA-960 OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-961. OXA-961 antibiotic_resistance ARO:3008738 OXA-961 ARO:3008738 OXA-961 OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-962. OXA-962 antibiotic_resistance ARO:3008739 OXA-962 ARO:3008739 OXA-962 OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-963. OXA-963 antibiotic_resistance ARO:3008740 OXA-963 ARO:3008740 OXA-963 OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-964. OXA-964 antibiotic_resistance ARO:3008741 OXA-964 ARO:3008741 OXA-964 OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-965. OXA-965 antibiotic_resistance ARO:3008742 OXA-965 ARO:3008742 OXA-965 OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-966. OXA-966 antibiotic_resistance ARO:3008743 OXA-966 ARO:3008743 OXA-966 OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-967. OXA-967 antibiotic_resistance ARO:3008744 OXA-967 ARO:3008744 OXA-967 OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-968. OXA-968 antibiotic_resistance ARO:3008745 OXA-968 ARO:3008745 OXA-968 OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-969. OXA-969 antibiotic_resistance ARO:3008746 OXA-969 ARO:3008746 OXA-969 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-970. OXA-970 antibiotic_resistance ARO:3008747 OXA-970 ARO:3008747 OXA-970 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-971. OXA-971 antibiotic_resistance ARO:3008748 OXA-971 ARO:3008748 OXA-971 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-972. OXA-972 antibiotic_resistance ARO:3008749 OXA-972 ARO:3008749 OXA-972 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-973. OXA-973 antibiotic_resistance ARO:3008750 OXA-973 ARO:3008750 OXA-973 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-974. OXA-974 antibiotic_resistance ARO:3008751 OXA-974 ARO:3008751 OXA-974 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-975. OXA-975 antibiotic_resistance ARO:3008752 OXA-975 ARO:3008752 OXA-975 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-976. OXA-976 antibiotic_resistance ARO:3008753 OXA-976 ARO:3008753 OXA-976 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-977. OXA-977 antibiotic_resistance ARO:3008754 OXA-977 ARO:3008754 OXA-977 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-978. OXA-978 antibiotic_resistance ARO:3008755 OXA-978 ARO:3008755 OXA-978 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-979. OXA-979 antibiotic_resistance ARO:3008756 OXA-979 ARO:3008756 OXA-979 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-980. OXA-980 antibiotic_resistance ARO:3008757 OXA-980 ARO:3008757 OXA-980 Class D beta-lactamase OXA-981. OXA-981 antibiotic_resistance ARO:3008758 OXA-981 ARO:3008758 OXA-981 OXA-294 family class D beta-lactamase OXA-982. OXA-982 antibiotic_resistance ARO:3008759 OXA-982 ARO:3008759 OXA-982 OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-983. OXA-983 antibiotic_resistance ARO:3008760 OXA-983 ARO:3008760 OXA-983 OXA-294 family class D beta-lactamase OXA-984. OXA-984 antibiotic_resistance ARO:3008761 OXA-984 ARO:3008761 OXA-984 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-985. OXA-985 antibiotic_resistance ARO:3008762 OXA-985 ARO:3008762 OXA-985 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-986. OXA-986 antibiotic_resistance ARO:3008763 OXA-986 ARO:3008763 OXA-986 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-987. OXA-987 antibiotic_resistance ARO:3008764 OXA-987 ARO:3008764 OXA-987 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-988. OXA-988 antibiotic_resistance ARO:3008765 OXA-988 ARO:3008765 OXA-988 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-989. OXA-989 antibiotic_resistance ARO:3008766 OXA-989 ARO:3008766 OXA-989 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-990. OXA-990 antibiotic_resistance ARO:3008767 OXA-990 ARO:3008767 OXA-990 OXA-134 family carbapenem-hydrolyzing class D beta-lactamase OXA-991. OXA-991 antibiotic_resistance ARO:3008768 OXA-991 ARO:3008768 OXA-991 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-992. OXA-992 antibiotic_resistance ARO:3008769 OXA-992 ARO:3008769 OXA-992 OXA-294 family class D beta-lactamase OXA-993. OXA-993 antibiotic_resistance ARO:3008770 OXA-993 ARO:3008770 OXA-993 OXA-294 family class D beta-lactamase OXA-994. OXA-994 antibiotic_resistance ARO:3008771 OXA-994 ARO:3008771 OXA-994 OXA-294 family class D beta-lactamase OXA-995. OXA-995 antibiotic_resistance ARO:3008772 OXA-995 ARO:3008772 OXA-995 OXA-294 family class D beta-lactamase OXA-996. OXA-996 antibiotic_resistance ARO:3008773 OXA-996 ARO:3008773 OXA-996 OXA-294 family class D beta-lactamase OXA-997. OXA-997 antibiotic_resistance ARO:3008774 OXA-997 ARO:3008774 OXA-997 OXA-294 family class D beta-lactamase OXA-998. OXA-998 antibiotic_resistance ARO:3008775 OXA-998 ARO:3008775 OXA-998 Class D beta-lactamase OXA-999. OXA-999 antibiotic_resistance ARO:3008776 OXA-999 ARO:3008776 OXA-999 Extended-spectrum class A beta-lactamase OXY-1-11. OXY-1-11 antibiotic_resistance ARO:3008777 OXY-1-11 ARO:3008777 OXY-1-11 Extended-spectrum class A beta-lactamase OXY-1-12. OXY-1-12 antibiotic_resistance ARO:3008778 OXY-1-12 ARO:3008778 OXY-1-12 Extended-spectrum class A beta-lactamase OXY-1-13. OXY-1-13 antibiotic_resistance ARO:3008779 OXY-1-13 ARO:3008779 OXY-1-13 Extended-spectrum class A beta-lactamase OXY-1-16. OXY-1-16 antibiotic_resistance ARO:3008780 OXY-1-16 ARO:3008780 OXY-1-16 Extended-spectrum class A beta-lactamase OXY-1-17. OXY-1-17 antibiotic_resistance ARO:3008781 OXY-1-17 ARO:3008781 OXY-1-17 Extended-spectrum class A beta-lactamase OXY-1-18. OXY-1-18 antibiotic_resistance ARO:3008782 OXY-1-18 ARO:3008782 OXY-1-18 Extended-spectrum class A beta-lactamase OXY-1-19. OXY-1-19 antibiotic_resistance ARO:3008783 OXY-1-19 ARO:3008783 OXY-1-19 Extended-spectrum class A beta-lactamase OXY-10-1. OXY-10-1 antibiotic_resistance ARO:3008784 OXY-10-1 ARO:3008784 OXY-10-1 Extended-spectrum class A beta-lactamase OXY-11-1. OXY-11-1 antibiotic_resistance ARO:3008785 OXY-11-1 ARO:3008785 OXY-11-1 Extended-spectrum class A beta-lactamase OXY-12-1. OXY-12-1 antibiotic_resistance ARO:3008786 OXY-12-1 ARO:3008786 OXY-12-1 Extended-spectrum class A beta-lactamase OXY-12-2. OXY-12-2 antibiotic_resistance ARO:3008787 OXY-12-2 ARO:3008787 OXY-12-2 Extended-spectrum class A beta-lactamase OXY-2-17. OXY-2-17 antibiotic_resistance ARO:3008788 OXY-2-17 ARO:3008788 OXY-2-17 Extended-spectrum class A beta-lactamase OXY-2-18. OXY-2-18 antibiotic_resistance ARO:3008789 OXY-2-18 ARO:3008789 OXY-2-18 Extended-spectrum class A beta-lactamase OXY-2-19. OXY-2-19 antibiotic_resistance ARO:3008790 OXY-2-19 ARO:3008790 OXY-2-19 Extended-spectrum class A beta-lactamase OXY-2-20. OXY-2-20 antibiotic_resistance ARO:3008791 OXY-2-20 ARO:3008791 OXY-2-20 Extended-spectrum class A beta-lactamase OXY-2-21. OXY-2-21 antibiotic_resistance ARO:3008792 OXY-2-21 ARO:3008792 OXY-2-21 Extended-spectrum class A beta-lactamase OXY-2-22. OXY-2-22 antibiotic_resistance ARO:3008793 OXY-2-22 ARO:3008793 OXY-2-22 Extended-spectrum class A beta-lactamase OXY-2-23. OXY-2-23 antibiotic_resistance ARO:3008794 OXY-2-23 ARO:3008794 OXY-2-23 Extended-spectrum class A beta-lactamase OXY-2-24. OXY-2-24 antibiotic_resistance ARO:3008795 OXY-2-24 ARO:3008795 OXY-2-24 Extended-spectrum class A beta-lactamase OXY-2-25. OXY-2-25 antibiotic_resistance ARO:3008796 OXY-2-25 ARO:3008796 OXY-2-25 Extended-spectrum class A beta-lactamase OXY-2-26. OXY-2-26 antibiotic_resistance ARO:3008797 OXY-2-26 ARO:3008797 OXY-2-26 Extended-spectrum class A beta-lactamase OXY-2-27. OXY-2-27 antibiotic_resistance ARO:3008798 OXY-2-27 ARO:3008798 OXY-2-27 Extended-spectrum class A beta-lactamase OXY-2-28. OXY-2-28 antibiotic_resistance ARO:3008799 OXY-2-28 ARO:3008799 OXY-2-28 Extended-spectrum class A beta-lactamase OXY-2-30. OXY-2-30 antibiotic_resistance ARO:3008800 OXY-2-30 ARO:3008800 OXY-2-30 Extended-spectrum class A beta-lactamase OXY-3-2. OXY-3-2 antibiotic_resistance ARO:3008801 OXY-3-2 ARO:3008801 OXY-3-2 Extended-spectrum class A beta-lactamase OXY-3-3. OXY-3-3 antibiotic_resistance ARO:3008802 OXY-3-3 ARO:3008802 OXY-3-3 Extended-spectrum class A beta-lactamase OXY-4-2. OXY-4-2 antibiotic_resistance ARO:3008803 OXY-4-2 ARO:3008803 OXY-4-2 Extended-spectrum class A beta-lactamase OXY-4-3. OXY-4-3 antibiotic_resistance ARO:3008804 OXY-4-3 ARO:3008804 OXY-4-3 Extended-spectrum class A beta-lactamase OXY-4-4. OXY-4-4 antibiotic_resistance ARO:3008805 OXY-4-4 ARO:3008805 OXY-4-4 Extended-spectrum class A beta-lactamase OXY-4-5. OXY-4-5 antibiotic_resistance ARO:3008806 OXY-4-5 ARO:3008806 OXY-4-5 Extended-spectrum class A beta-lactamase OXY-5-10. OXY-5-10 antibiotic_resistance ARO:3008807 OXY-5-10 ARO:3008807 OXY-5-10 Extended-spectrum class A beta-lactamase OXY-5-11. OXY-5-11 antibiotic_resistance ARO:3008808 OXY-5-11 ARO:3008808 OXY-5-11 Extended-spectrum class A beta-lactamase OXY-5-6. OXY-5-6 antibiotic_resistance ARO:3008809 OXY-5-6 ARO:3008809 OXY-5-6 Extended-spectrum class A beta-lactamase OXY-5-7. OXY-5-7 antibiotic_resistance ARO:3008810 OXY-5-7 ARO:3008810 OXY-5-7 Extended-spectrum class A beta-lactamase OXY-5-8. OXY-5-8 antibiotic_resistance ARO:3008811 OXY-5-8 ARO:3008811 OXY-5-8 Extended-spectrum class A beta-lactamase OXY-6-10. OXY-6-10 antibiotic_resistance ARO:3008812 OXY-6-10 ARO:3008812 OXY-6-10 Extended-spectrum class A beta-lactamase OXY-6-11. OXY-6-11 antibiotic_resistance ARO:3008813 OXY-6-11 ARO:3008813 OXY-6-11 Extended-spectrum class A beta-lactamase OXY-6-5. OXY-6-5 antibiotic_resistance ARO:3008814 OXY-6-5 ARO:3008814 OXY-6-5 Extended-spectrum class A beta-lactamase OXY-6-7. OXY-6-7 antibiotic_resistance ARO:3008815 OXY-6-7 ARO:3008815 OXY-6-7 Extended-spectrum class A beta-lactamase OXY-7-1. OXY-7-1 antibiotic_resistance ARO:3008816 OXY-7-1 ARO:3008816 OXY-7-1 Extended-spectrum class A beta-lactamase OXY-8-1. OXY-8-1 antibiotic_resistance ARO:3008817 OXY-8-1 ARO:3008817 OXY-8-1 Extended-spectrum class A beta-lactamase OXY-8-2. OXY-8-2 antibiotic_resistance ARO:3008818 OXY-8-2 ARO:3008818 OXY-8-2 Extended-spectrum class A beta-lactamase OXY-8-3. OXY-8-3 antibiotic_resistance ARO:3008819 OXY-8-3 ARO:3008819 OXY-8-3 Extended-spectrum class A beta-lactamase OXY-9-1. OXY-9-1 antibiotic_resistance ARO:3008820 OXY-9-1 ARO:3008820 OXY-9-1 Carbapenem-hydrolyzing class A beta-lactamase PAD-1. PAD-1 antibiotic_resistance ARO:3008821 PAD-1 ARO:3008821 PAD-1 Subclass B3 metallo-beta-lactamase PAM-5. PAM-5 antibiotic_resistance ARO:3008822 PAM-5 ARO:3008822 PAM-5 BlaZ family penicillin-hydrolyzing class A beta-lactamase PC1. PC1 antibiotic_resistance ARO:3008823 PC1 ARO:3008823 PC1 Inhibitor-resistant class C beta-lactamase PDC-477. PDC-477 antibiotic_resistance ARO:3008824 PDC-477 ARO:3008824 PDC-477 Inhibitor-resistant class C beta-lactamase PDC-478. PDC-478 antibiotic_resistance ARO:3008825 PDC-478 ARO:3008825 PDC-478 Inhibitor-resistant extended-spectrum class C beta-lactamase PDC-479. PDC-479 antibiotic_resistance ARO:3008826 PDC-479 ARO:3008826 PDC-479 Inhibitor-resistant extended-spectrum class C beta-lactamase PDC-480. PDC-480 antibiotic_resistance ARO:3008827 PDC-480 ARO:3008827 PDC-480 Inhibitor-resistant extended-spectrum class C beta-lactamase PDC-481. PDC-481 antibiotic_resistance ARO:3008828 PDC-481 ARO:3008828 PDC-481 Inhibitor-resistant extended-spectrum class C beta-lactamase PDC-482. PDC-482 antibiotic_resistance ARO:3008829 PDC-482 ARO:3008829 PDC-482 Inhibitor-resistant class C beta-lactamase PDC-483. PDC-483 antibiotic_resistance ARO:3008830 PDC-483 ARO:3008830 PDC-483 Class C beta-lactamase PDC-484. PDC-484 antibiotic_resistance ARO:3008831 PDC-484 ARO:3008831 PDC-484 Class C beta-lactamase PDC-485. PDC-485 antibiotic_resistance ARO:3008832 PDC-485 ARO:3008832 PDC-485 Class C beta-lactamase PDC-486. PDC-486 antibiotic_resistance ARO:3008833 PDC-486 ARO:3008833 PDC-486 Inhibitor-resistant extended-spectrum class C beta-lactamase PDC-487. PDC-487 antibiotic_resistance ARO:3008834 PDC-487 ARO:3008834 PDC-487 Class C beta-lactamase PDC-488. PDC-488 antibiotic_resistance ARO:3008835 PDC-488 ARO:3008835 PDC-488 Class C beta-lactamase PDC-489. PDC-489 antibiotic_resistance ARO:3008836 PDC-489 ARO:3008836 PDC-489 Class C beta-lactamase PDC-490. PDC-490 antibiotic_resistance ARO:3008837 PDC-490 ARO:3008837 PDC-490 Class C beta-lactamase PDC-491. PDC-491 antibiotic_resistance ARO:3008838 PDC-491 ARO:3008838 PDC-491 Class C beta-lactamase PDC-492. PDC-492 antibiotic_resistance ARO:3008839 PDC-492 ARO:3008839 PDC-492 Class C beta-lactamase PDC-493. PDC-493 antibiotic_resistance ARO:3008840 PDC-493 ARO:3008840 PDC-493 Class C beta-lactamase PDC-494. PDC-494 antibiotic_resistance ARO:3008841 PDC-494 ARO:3008841 PDC-494 Class C beta-lactamase PDC-495. PDC-495 antibiotic_resistance ARO:3008842 PDC-495 ARO:3008842 PDC-495 Class C beta-lactamase PDC-496. PDC-496 antibiotic_resistance ARO:3008843 PDC-496 ARO:3008843 PDC-496 Inhibitor-resistant extended-spectrum class C beta-lactamase PDC-497. PDC-497 antibiotic_resistance ARO:3008844 PDC-497 ARO:3008844 PDC-497 Class C beta-lactamase PDC-498. PDC-498 antibiotic_resistance ARO:3008845 PDC-498 ARO:3008845 PDC-498 Class C beta-lactamase PDC-499. PDC-499 antibiotic_resistance ARO:3008846 PDC-499 ARO:3008846 PDC-499 Inhibitor-resistant class C beta-lactamase PDC-500. PDC-500 antibiotic_resistance ARO:3008847 PDC-500 ARO:3008847 PDC-500 Class C beta-lactamase PDC-501. PDC-501 antibiotic_resistance ARO:3008848 PDC-501 ARO:3008848 PDC-501 Class C beta-lactamase PDC-502. PDC-502 antibiotic_resistance ARO:3008849 PDC-502 ARO:3008849 PDC-502 Class C beta-lactamase PDC-503. PDC-503 antibiotic_resistance ARO:3008850 PDC-503 ARO:3008850 PDC-503 Class C beta-lactamase PDC-504. PDC-504 antibiotic_resistance ARO:3008851 PDC-504 ARO:3008851 PDC-504 Class C beta-lactamase PDC-505. PDC-505 antibiotic_resistance ARO:3008852 PDC-505 ARO:3008852 PDC-505 Class C beta-lactamase PDC-506. PDC-506 antibiotic_resistance ARO:3008853 PDC-506 ARO:3008853 PDC-506 Class C beta-lactamase PDC-507. PDC-507 antibiotic_resistance ARO:3008854 PDC-507 ARO:3008854 PDC-507 Class C beta-lactamase PDC-508. PDC-508 antibiotic_resistance ARO:3008855 PDC-508 ARO:3008855 PDC-508 Class C beta-lactamase PDC-509. PDC-509 antibiotic_resistance ARO:3008856 PDC-509 ARO:3008856 PDC-509 Inhibitor-resistant class C beta-lactamase PDC-510. PDC-510 antibiotic_resistance ARO:3008857 PDC-510 ARO:3008857 PDC-510 Class C beta-lactamase PDC-511. PDC-511 antibiotic_resistance ARO:3008858 PDC-511 ARO:3008858 PDC-511 Class C beta-lactamase PDC-512. PDC-512 antibiotic_resistance ARO:3008859 PDC-512 ARO:3008859 PDC-512 Class C beta-lactamase PDC-513. PDC-513 antibiotic_resistance ARO:3008860 PDC-513 ARO:3008860 PDC-513 Class C beta-lactamase PDC-514. PDC-514 antibiotic_resistance ARO:3008861 PDC-514 ARO:3008861 PDC-514 Inhibitor-resistant extended-spectrum class C beta-lactamase PDC-515. PDC-515 antibiotic_resistance ARO:3008862 PDC-515 ARO:3008862 PDC-515 Class C beta-lactamase PDC-516. PDC-516 antibiotic_resistance ARO:3008863 PDC-516 ARO:3008863 PDC-516 Class C beta-lactamase PDC-517. PDC-517 antibiotic_resistance ARO:3008864 PDC-517 ARO:3008864 PDC-517 Class C beta-lactamase PDC-518. PDC-518 antibiotic_resistance ARO:3008865 PDC-518 ARO:3008865 PDC-518 Inhibitor-resistant cephalosporin-hydrolyzing class C beta-lactamase PDC-519. PDC-519 antibiotic_resistance ARO:3008866 PDC-519 ARO:3008866 PDC-519 Class C beta-lactamase PDC-520. PDC-520 antibiotic_resistance ARO:3008867 PDC-520 ARO:3008867 PDC-520 Class C beta-lactamase PDC-521. PDC-521 antibiotic_resistance ARO:3008868 PDC-521 ARO:3008868 PDC-521 Class C beta-lactamase PDC-522. PDC-522 antibiotic_resistance ARO:3008869 PDC-522 ARO:3008869 PDC-522 Class C beta-lactamase PDC-523. PDC-523 antibiotic_resistance ARO:3008870 PDC-523 ARO:3008870 PDC-523 Class C beta-lactamase PDC-524. PDC-524 antibiotic_resistance ARO:3008871 PDC-524 ARO:3008871 PDC-524 Class C beta-lactamase PDC-525. PDC-525 antibiotic_resistance ARO:3008872 PDC-525 ARO:3008872 PDC-525 Class C beta-lactamase PDC-526. PDC-526 antibiotic_resistance ARO:3008873 PDC-526 ARO:3008873 PDC-526 Class C beta-lactamase PDC-527. PDC-527 antibiotic_resistance ARO:3008874 PDC-527 ARO:3008874 PDC-527 Class C beta-lactamase PDC-528. PDC-528 antibiotic_resistance ARO:3008875 PDC-528 ARO:3008875 PDC-528 Class C beta-lactamase PDC-529. PDC-529 antibiotic_resistance ARO:3008876 PDC-529 ARO:3008876 PDC-529 Class C beta-lactamase PDC-530. PDC-530 antibiotic_resistance ARO:3008877 PDC-530 ARO:3008877 PDC-530 Inhibitor-resistant class C beta-lactamase PDC-531. PDC-531 antibiotic_resistance ARO:3008878 PDC-531 ARO:3008878 PDC-531 Class C beta-lactamase PDC-532. PDC-532 antibiotic_resistance ARO:3008879 PDC-532 ARO:3008879 PDC-532 Class C beta-lactamase PDC-533. PDC-533 antibiotic_resistance ARO:3008880 PDC-533 ARO:3008880 PDC-533 Class C beta-lactamase PDC-534. PDC-534 antibiotic_resistance ARO:3008881 PDC-534 ARO:3008881 PDC-534 Class C beta-lactamase PDC-535. PDC-535 antibiotic_resistance ARO:3008882 PDC-535 ARO:3008882 PDC-535 Class C beta-lactamase PDC-536. PDC-536 antibiotic_resistance ARO:3008883 PDC-536 ARO:3008883 PDC-536 Inhibitor-resistant extended-spectrum class C beta-lactamase PDC-537. PDC-537 antibiotic_resistance ARO:3008884 PDC-537 ARO:3008884 PDC-537 Class C beta-lactamase PDC-538. PDC-538 antibiotic_resistance ARO:3008885 PDC-538 ARO:3008885 PDC-538 Class C beta-lactamase PDC-539. PDC-539 antibiotic_resistance ARO:3008886 PDC-539 ARO:3008886 PDC-539 Class C beta-lactamase PDC-540. PDC-540 antibiotic_resistance ARO:3008887 PDC-540 ARO:3008887 PDC-540 Class C beta-lactamase PDC-541. PDC-541 antibiotic_resistance ARO:3008888 PDC-541 ARO:3008888 PDC-541 Class C beta-lactamase PDC-542. PDC-542 antibiotic_resistance ARO:3008889 PDC-542 ARO:3008889 PDC-542 Class C beta-lactamase PDC-543. PDC-543 antibiotic_resistance ARO:3008890 PDC-543 ARO:3008890 PDC-543 Class C beta-lactamase PDC-544. PDC-544 antibiotic_resistance ARO:3008891 PDC-544 ARO:3008891 PDC-544 Class C beta-lactamase PDC-545. PDC-545 antibiotic_resistance ARO:3008892 PDC-545 ARO:3008892 PDC-545 Class C beta-lactamase PDC-546. PDC-546 antibiotic_resistance ARO:3008893 PDC-546 ARO:3008893 PDC-546 Class C beta-lactamase PDC-547. PDC-547 antibiotic_resistance ARO:3008894 PDC-547 ARO:3008894 PDC-547 Class C beta-lactamase PDC-548. PDC-548 antibiotic_resistance ARO:3008895 PDC-548 ARO:3008895 PDC-548 Class C beta-lactamase PDC-549. PDC-549 antibiotic_resistance ARO:3008896 PDC-549 ARO:3008896 PDC-549 Class C beta-lactamase PDC-550. PDC-550 antibiotic_resistance ARO:3008897 PDC-550 ARO:3008897 PDC-550 Class C beta-lactamase PDC-551. PDC-551 antibiotic_resistance ARO:3008898 PDC-551 ARO:3008898 PDC-551 Class C beta-lactamase PDC-552. PDC-552 antibiotic_resistance ARO:3008899 PDC-552 ARO:3008899 PDC-552 Class C beta-lactamase PDC-553. PDC-553 antibiotic_resistance ARO:3008900 PDC-553 ARO:3008900 PDC-553 Class C beta-lactamase PDC-554. PDC-554 antibiotic_resistance ARO:3008901 PDC-554 ARO:3008901 PDC-554 Class C beta-lactamase PDC-555. PDC-555 antibiotic_resistance ARO:3008902 PDC-555 ARO:3008902 PDC-555 Class C beta-lactamase PDC-556. PDC-556 antibiotic_resistance ARO:3008903 PDC-556 ARO:3008903 PDC-556 Class C beta-lactamase PDC-557. PDC-557 antibiotic_resistance ARO:3008904 PDC-557 ARO:3008904 PDC-557 Class C beta-lactamase PDC-558. PDC-558 antibiotic_resistance ARO:3008905 PDC-558 ARO:3008905 PDC-558 Class C beta-lactamase PDC-559. PDC-559 antibiotic_resistance ARO:3008906 PDC-559 ARO:3008906 PDC-559 Class C beta-lactamase PDC-560. PDC-560 antibiotic_resistance ARO:3008907 PDC-560 ARO:3008907 PDC-560 Class C beta-lactamase PDC-561. PDC-561 antibiotic_resistance ARO:3008908 PDC-561 ARO:3008908 PDC-561 Class C beta-lactamase PDC-562. PDC-562 antibiotic_resistance ARO:3008909 PDC-562 ARO:3008909 PDC-562 Class C beta-lactamase PDC-563. PDC-563 antibiotic_resistance ARO:3008910 PDC-563 ARO:3008910 PDC-563 Class C beta-lactamase PDC-564. PDC-564 antibiotic_resistance ARO:3008911 PDC-564 ARO:3008911 PDC-564 Class C beta-lactamase PDC-565. PDC-565 antibiotic_resistance ARO:3008912 PDC-565 ARO:3008912 PDC-565 Class C beta-lactamase PDC-566. PDC-566 antibiotic_resistance ARO:3008913 PDC-566 ARO:3008913 PDC-566 Class C beta-lactamase PDC-567. PDC-567 antibiotic_resistance ARO:3008914 PDC-567 ARO:3008914 PDC-567 Class C beta-lactamase PDC-568. PDC-568 antibiotic_resistance ARO:3008915 PDC-568 ARO:3008915 PDC-568 Class C beta-lactamase PDC-569. PDC-569 antibiotic_resistance ARO:3008916 PDC-569 ARO:3008916 PDC-569 Class C beta-lactamase PDC-570. PDC-570 antibiotic_resistance ARO:3008917 PDC-570 ARO:3008917 PDC-570 Class C beta-lactamase PDC-571. PDC-571 antibiotic_resistance ARO:3008918 PDC-571 ARO:3008918 PDC-571 Class C beta-lactamase PDC-572. PDC-572 antibiotic_resistance ARO:3008919 PDC-572 ARO:3008919 PDC-572 Class C beta-lactamase PDC-573. PDC-573 antibiotic_resistance ARO:3008920 PDC-573 ARO:3008920 PDC-573 Class C beta-lactamase PDC-574. PDC-574 antibiotic_resistance ARO:3008921 PDC-574 ARO:3008921 PDC-574 Class C beta-lactamase PDC-575. PDC-575 antibiotic_resistance ARO:3008922 PDC-575 ARO:3008922 PDC-575 Class C beta-lactamase PDC-576. PDC-576 antibiotic_resistance ARO:3008923 PDC-576 ARO:3008923 PDC-576 Inhibitor-resistant extended-spectrum class C beta-lactamase PDC-577. PDC-577 antibiotic_resistance ARO:3008924 PDC-577 ARO:3008924 PDC-577 Class C beta-lactamase PDC-578. PDC-578 antibiotic_resistance ARO:3008925 PDC-578 ARO:3008925 PDC-578 Class C beta-lactamase PDC-579. PDC-579 antibiotic_resistance ARO:3008926 PDC-579 ARO:3008926 PDC-579 Class C beta-lactamase PDC-580. PDC-580 antibiotic_resistance ARO:3008927 PDC-580 ARO:3008927 PDC-580 Class C beta-lactamase PDC-581. PDC-581 antibiotic_resistance ARO:3008928 PDC-581 ARO:3008928 PDC-581 Class C beta-lactamase PDC-582. PDC-582 antibiotic_resistance ARO:3008929 PDC-582 ARO:3008929 PDC-582 Class C beta-lactamase PDC-583. PDC-583 antibiotic_resistance ARO:3008930 PDC-583 ARO:3008930 PDC-583 Class C beta-lactamase PDC-584. PDC-584 antibiotic_resistance ARO:3008931 PDC-584 ARO:3008931 PDC-584 Class C beta-lactamase PDC-585. PDC-585 antibiotic_resistance ARO:3008932 PDC-585 ARO:3008932 PDC-585 Class C beta-lactamase PDC-586. PDC-586 antibiotic_resistance ARO:3008933 PDC-586 ARO:3008933 PDC-586 Class C beta-lactamase PDC-587. PDC-587 antibiotic_resistance ARO:3008934 PDC-587 ARO:3008934 PDC-587 Class C beta-lactamase PDC-588. PDC-588 antibiotic_resistance ARO:3008935 PDC-588 ARO:3008935 PDC-588 Class C beta-lactamase PDC-589. PDC-589 antibiotic_resistance ARO:3008936 PDC-589 ARO:3008936 PDC-589 Class C beta-lactamase PDC-590. PDC-590 antibiotic_resistance ARO:3008937 PDC-590 ARO:3008937 PDC-590 Class C beta-lactamase PDC-591. PDC-591 antibiotic_resistance ARO:3008938 PDC-591 ARO:3008938 PDC-591 Class C beta-lactamase PDC-592. PDC-592 antibiotic_resistance ARO:3008939 PDC-592 ARO:3008939 PDC-592 Class C beta-lactamase PDC-593. PDC-593 antibiotic_resistance ARO:3008940 PDC-593 ARO:3008940 PDC-593 Class C beta-lactamase PDC-594. PDC-594 antibiotic_resistance ARO:3008941 PDC-594 ARO:3008941 PDC-594 Class C beta-lactamase PDC-595. PDC-595 antibiotic_resistance ARO:3008942 PDC-595 ARO:3008942 PDC-595 Class C beta-lactamase PDC-596. PDC-596 antibiotic_resistance ARO:3008943 PDC-596 ARO:3008943 PDC-596 Class C beta-lactamase PDC-597. PDC-597 antibiotic_resistance ARO:3008944 PDC-597 ARO:3008944 PDC-597 Class C beta-lactamase PDC-598. PDC-598 antibiotic_resistance ARO:3008945 PDC-598 ARO:3008945 PDC-598 Class C beta-lactamase PDC-599. PDC-599 antibiotic_resistance ARO:3008946 PDC-599 ARO:3008946 PDC-599 Class C beta-lactamase PDC-600. PDC-600 antibiotic_resistance ARO:3008947 PDC-600 ARO:3008947 PDC-600 Class C beta-lactamase PDC-601. PDC-601 antibiotic_resistance ARO:3008948 PDC-601 ARO:3008948 PDC-601 Class C beta-lactamase PDC-602. PDC-602 antibiotic_resistance ARO:3008949 PDC-602 ARO:3008949 PDC-602 Class C beta-lactamase PDC-603. PDC-603 antibiotic_resistance ARO:3008950 PDC-603 ARO:3008950 PDC-603 Class C beta-lactamase PDC-604. PDC-604 antibiotic_resistance ARO:3008951 PDC-604 ARO:3008951 PDC-604 Class C beta-lactamase PDC-605. PDC-605 antibiotic_resistance ARO:3008952 PDC-605 ARO:3008952 PDC-605 Class C beta-lactamase PDC-606. PDC-606 antibiotic_resistance ARO:3008953 PDC-606 ARO:3008953 PDC-606 Class C beta-lactamase PDC-607. PDC-607 antibiotic_resistance ARO:3008954 PDC-607 ARO:3008954 PDC-607 Class C beta-lactamase PDC-608. PDC-608 antibiotic_resistance ARO:3008955 PDC-608 ARO:3008955 PDC-608 Class C beta-lactamase PDC-609. PDC-609 antibiotic_resistance ARO:3008956 PDC-609 ARO:3008956 PDC-609 Class C beta-lactamase PDC-610. PDC-610 antibiotic_resistance ARO:3008957 PDC-610 ARO:3008957 PDC-610 Class C beta-lactamase PDC-611. PDC-611 antibiotic_resistance ARO:3008958 PDC-611 ARO:3008958 PDC-611 Class C beta-lactamase PDC-612. PDC-612 antibiotic_resistance ARO:3008959 PDC-612 ARO:3008959 PDC-612 Class C beta-lactamase PDC-613. PDC-613 antibiotic_resistance ARO:3008960 PDC-613 ARO:3008960 PDC-613 Class C beta-lactamase PDC-614. PDC-614 antibiotic_resistance ARO:3008961 PDC-614 ARO:3008961 PDC-614 Class C beta-lactamase PDC-615. PDC-615 antibiotic_resistance ARO:3008962 PDC-615 ARO:3008962 PDC-615 Class C beta-lactamase PDC-616. PDC-616 antibiotic_resistance ARO:3008963 PDC-616 ARO:3008963 PDC-616 Class C beta-lactamase PDC-617. PDC-617 antibiotic_resistance ARO:3008964 PDC-617 ARO:3008964 PDC-617 Class C beta-lactamase PDC-618. PDC-618 antibiotic_resistance ARO:3008965 PDC-618 ARO:3008965 PDC-618 Class C beta-lactamase PDC-619. PDC-619 antibiotic_resistance ARO:3008966 PDC-619 ARO:3008966 PDC-619 Class C beta-lactamase PDC-620. PDC-620 antibiotic_resistance ARO:3008967 PDC-620 ARO:3008967 PDC-620 Class C beta-lactamase PDC-621. PDC-621 antibiotic_resistance ARO:3008968 PDC-621 ARO:3008968 PDC-621 Class C beta-lactamase PDC-622. PDC-622 antibiotic_resistance ARO:3008969 PDC-622 ARO:3008969 PDC-622 Class C beta-lactamase PDC-623. PDC-623 antibiotic_resistance ARO:3008970 PDC-623 ARO:3008970 PDC-623 Class C beta-lactamase PDC-624. PDC-624 antibiotic_resistance ARO:3008971 PDC-624 ARO:3008971 PDC-624 Class C beta-lactamase PDC-625. PDC-625 antibiotic_resistance ARO:3008972 PDC-625 ARO:3008972 PDC-625 Class C beta-lactamase PDC-626. PDC-626 antibiotic_resistance ARO:3008973 PDC-626 ARO:3008973 PDC-626 Class C beta-lactamase PDC-627. PDC-627 antibiotic_resistance ARO:3008974 PDC-627 ARO:3008974 PDC-627 Class C beta-lactamase PDC-628. PDC-628 antibiotic_resistance ARO:3008975 PDC-628 ARO:3008975 PDC-628 Class C beta-lactamase PDC-629. PDC-629 antibiotic_resistance ARO:3008976 PDC-629 ARO:3008976 PDC-629 Class C beta-lactamase PDC-630. PDC-630 antibiotic_resistance ARO:3008977 PDC-630 ARO:3008977 PDC-630 Class C beta-lactamase PDC-631. PDC-631 antibiotic_resistance ARO:3008978 PDC-631 ARO:3008978 PDC-631 Class C beta-lactamase PDC-632. PDC-632 antibiotic_resistance ARO:3008979 PDC-632 ARO:3008979 PDC-632 Class C beta-lactamase PDC-633. PDC-633 antibiotic_resistance ARO:3008980 PDC-633 ARO:3008980 PDC-633 Class C beta-lactamase PDC-634. PDC-634 antibiotic_resistance ARO:3008981 PDC-634 ARO:3008981 PDC-634 Class C beta-lactamase PDC-635. PDC-635 antibiotic_resistance ARO:3008982 PDC-635 ARO:3008982 PDC-635 Class C beta-lactamase PDC-636. PDC-636 antibiotic_resistance ARO:3008983 PDC-636 ARO:3008983 PDC-636 Class C beta-lactamase PDC-637. PDC-637 antibiotic_resistance ARO:3008984 PDC-637 ARO:3008984 PDC-637 Class C beta-lactamase PDC-638. PDC-638 antibiotic_resistance ARO:3008985 PDC-638 ARO:3008985 PDC-638 Class C beta-lactamase PDC-639. PDC-639 antibiotic_resistance ARO:3008986 PDC-639 ARO:3008986 PDC-639 Class C beta-lactamase PDC-640. PDC-640 antibiotic_resistance ARO:3008987 PDC-640 ARO:3008987 PDC-640 Class A beta-lactamase PEN-A10. PEN-A10 antibiotic_resistance ARO:3008988 PEN-A10 ARO:3008988 PEN-A10 Class A beta-lactamase PEN-A11. PEN-A11 antibiotic_resistance ARO:3008989 PEN-A11 ARO:3008989 PEN-A11 Class A beta-lactamase PEN-A12. PEN-A12 antibiotic_resistance ARO:3008990 PEN-A12 ARO:3008990 PEN-A12 Class A beta-lactamase PEN-A13. PEN-A13 antibiotic_resistance ARO:3008991 PEN-A13 ARO:3008991 PEN-A13 Class A beta-lactamase PEN-A15. PEN-A15 antibiotic_resistance ARO:3008992 PEN-A15 ARO:3008992 PEN-A15 Class A beta-lactamase PEN-A16. PEN-A16 antibiotic_resistance ARO:3008993 PEN-A16 ARO:3008993 PEN-A16 Class A beta-lactamase PEN-A17. PEN-A17 antibiotic_resistance ARO:3008994 PEN-A17 ARO:3008994 PEN-A17 Class A beta-lactamase PEN-A18. PEN-A18 antibiotic_resistance ARO:3008995 PEN-A18 ARO:3008995 PEN-A18 Class A beta-lactamase PEN-A19. PEN-A19 antibiotic_resistance ARO:3008996 PEN-A19 ARO:3008996 PEN-A19 Class A beta-lactamase PEN-A1. PEN-A1 antibiotic_resistance ARO:3008997 PEN-A1 ARO:3008997 PEN-A1 Class A beta-lactamase PEN-A20. PEN-A20 antibiotic_resistance ARO:3008998 PEN-A20 ARO:3008998 PEN-A20 Class A beta-lactamase PEN-A21. PEN-A21 antibiotic_resistance ARO:3008999 PEN-A21 ARO:3008999 PEN-A21 Class A beta-lactamase PEN-A22. PEN-A22 antibiotic_resistance ARO:3009000 PEN-A22 ARO:3009000 PEN-A22 Class A beta-lactamase PEN-A23. PEN-A23 antibiotic_resistance ARO:3009001 PEN-A23 ARO:3009001 PEN-A23 Class A beta-lactamase PEN-A24. PEN-A24 antibiotic_resistance ARO:3009002 PEN-A24 ARO:3009002 PEN-A24 Class A beta-lactamase PEN-A25. PEN-A25 antibiotic_resistance ARO:3009003 PEN-A25 ARO:3009003 PEN-A25 Class A beta-lactamase PEN-A26. PEN-A26 antibiotic_resistance ARO:3009004 PEN-A26 ARO:3009004 PEN-A26 Class A beta-lactamase PEN-A27. PEN-A27 antibiotic_resistance ARO:3009005 PEN-A27 ARO:3009005 PEN-A27 Class A beta-lactamase PEN-A28. PEN-A28 antibiotic_resistance ARO:3009006 PEN-A28 ARO:3009006 PEN-A28 Class A beta-lactamase PEN-A29. PEN-A29 antibiotic_resistance ARO:3009007 PEN-A29 ARO:3009007 PEN-A29 Class A beta-lactamase PEN-A2. PEN-A2 antibiotic_resistance ARO:3009008 PEN-A2 ARO:3009008 PEN-A2 Class A beta-lactamase PEN-A30. PEN-A30 antibiotic_resistance ARO:3009009 PEN-A30 ARO:3009009 PEN-A30 Class A beta-lactamase PEN-A31. PEN-A31 antibiotic_resistance ARO:3009010 PEN-A31 ARO:3009010 PEN-A31 Class A beta-lactamase PEN-A32. PEN-A32 antibiotic_resistance ARO:3009011 PEN-A32 ARO:3009011 PEN-A32 Class A beta-lactamase PEN-A33. PEN-A33 antibiotic_resistance ARO:3009012 PEN-A33 ARO:3009012 PEN-A33 Class A beta-lactamase PEN-A34. PEN-A34 antibiotic_resistance ARO:3009013 PEN-A34 ARO:3009013 PEN-A34 Class A beta-lactamase PEN-A35. PEN-A35 antibiotic_resistance ARO:3009014 PEN-A35 ARO:3009014 PEN-A35 Class A beta-lactamase PEN-A37. PEN-A37 antibiotic_resistance ARO:3009015 PEN-A37 ARO:3009015 PEN-A37 Class A beta-lactamase PEN-A38. PEN-A38 antibiotic_resistance ARO:3009016 PEN-A38 ARO:3009016 PEN-A38 Class A beta-lactamase PEN-A3. PEN-A3 antibiotic_resistance ARO:3009017 PEN-A3 ARO:3009017 PEN-A3 Class A beta-lactamase PEN-A5. PEN-A5 antibiotic_resistance ARO:3009018 PEN-A5 ARO:3009018 PEN-A5 Class A beta-lactamase PEN-A6. PEN-A6 antibiotic_resistance ARO:3009019 PEN-A6 ARO:3009019 PEN-A6 Class A beta-lactamase PEN-A7. PEN-A7 antibiotic_resistance ARO:3009020 PEN-A7 ARO:3009020 PEN-A7 Class A beta-lactamase PEN-A8. PEN-A8 antibiotic_resistance ARO:3009021 PEN-A8 ARO:3009021 PEN-A8 Class A beta-lactamase PEN-A9. PEN-A9 antibiotic_resistance ARO:3009022 PEN-A9 ARO:3009022 PEN-A9 Class A beta-lactamase PEN-B1. PEN-B1 antibiotic_resistance ARO:3009023 PEN-B1 ARO:3009023 PEN-B1 Class A beta-lactamase PEN-B2. PEN-B2 antibiotic_resistance ARO:3009024 PEN-B2 ARO:3009024 PEN-B2 Class A beta-lactamase PEN-B3. PEN-B3 antibiotic_resistance ARO:3009025 PEN-B3 ARO:3009025 PEN-B3 Class A beta-lactamase PEN-B4. PEN-B4 antibiotic_resistance ARO:3009026 PEN-B4 ARO:3009026 PEN-B4 Extended-spectrum class A beta-lactamase PER-17. PER-17 antibiotic_resistance ARO:3009027 PER-17 ARO:3009027 PER-17 Extended-spectrum class A beta-lactamase PER-18. PER-18 antibiotic_resistance ARO:3009028 PER-18 ARO:3009028 PER-18 Subclass B3 metallo-beta-lactamase PJM-2. PJM-2 antibiotic_resistance ARO:3009029 PJM-2 ARO:3009029 PJM-2 Class A beta-lactamase PLA-4. PLA-4 antibiotic_resistance ARO:3009030 PLA-4 ARO:3009030 PLA-4 Class A beta-lactamase PLA-5. PLA-5 antibiotic_resistance ARO:3009031 PLA-5 ARO:3009031 PLA-5 Class C beta-lactamase PNC-1. PNC-1 antibiotic_resistance ARO:3009032 PNC-1 ARO:3009032 PNC-1 Extended-spectrum class C beta-lactamase PNC-2. PNC-2 antibiotic_resistance ARO:3009033 PNC-2 ARO:3009033 PNC-2 Extended-spectrum class C beta-lactamase PNC-3. PNC-3 antibiotic_resistance ARO:3009034 PNC-3 ARO:3009034 PNC-3 Extended-spectrum beta-lactamase RAA-1. RAA-1 antibiotic_resistance ARO:3009035 RAA-1 ARO:3009035 RAA-1 Extended-spectrum class A beta-lactamase RAHN-3. RAHN-3 antibiotic_resistance ARO:3009036 RAHN-3 ARO:3009036 RAHN-3 Extended-spectrum class A beta-lactamase RAHN-4. RAHN-4 antibiotic_resistance ARO:3009037 RAHN-4 ARO:3009037 RAHN-4 Extended-spectrum class A beta-lactamase RAHN-5. RAHN-5 antibiotic_resistance ARO:3009038 RAHN-5 ARO:3009038 RAHN-5 Extended-spectrum class A beta-lactamase RAHN-6. RAHN-6 antibiotic_resistance ARO:3009039 RAHN-6 ARO:3009039 RAHN-6 Extended-spectrum class A beta-lactamase RASA-1. RASA-1 antibiotic_resistance ARO:3009040 RASA-1 ARO:3009040 RASA-1 Class C beta-lactamase RSC1-1. RSC1-1 antibiotic_resistance ARO:3009041 RSC1-1 ARO:3009041 RSC1-1 Class D beta-lactamase RSD1-1. RSD1-1 antibiotic_resistance ARO:3009042 RSD1-1 ARO:3009042 RSD1-1 Class A beta-lactamase SED-2. SED-2 antibiotic_resistance ARO:3009044 SED-2 ARO:3009044 SED-2 Carbapenem-hydrolyzing class A beta-lactamase SFC-2. SFC-2 antibiotic_resistance ARO:3009045 SFC-2 ARO:3009045 SFC-2 Extended-spectrum class C beta-lactamase SFDC-1. SFDC-1 antibiotic_resistance ARO:3009046 SFDC-1 ARO:3009046 SFDC-1 Broad-spectrum class A beta-lactamase SHV-229. SHV-229 antibiotic_resistance ARO:3009048 SHV-229 ARO:3009048 SHV-229 Extended-spectrum class A beta-lactamase SHV-230. SHV-230 antibiotic_resistance ARO:3009049 SHV-230 ARO:3009049 SHV-230 Inhibitor-resistant extended-spectrum class A beta-lactamase SHV-231. SHV-231 antibiotic_resistance ARO:3009050 SHV-231 ARO:3009050 SHV-231 Class A beta-lactamase SHV-232. SHV-232 antibiotic_resistance ARO:3009051 SHV-232 ARO:3009051 SHV-232 Inhibitor-resistant class A beta-lactamase SHV-233. SHV-233 antibiotic_resistance ARO:3009052 SHV-233 ARO:3009052 SHV-233 Inhibitor-resistant class A beta-lactamase SHV-234. SHV-234 antibiotic_resistance ARO:3009053 SHV-234 ARO:3009053 SHV-234 Class A beta-lactamase SHV-235. SHV-235 antibiotic_resistance ARO:3009054 SHV-235 ARO:3009054 SHV-235 Class A beta-lactamase SHV-236. SHV-236 antibiotic_resistance ARO:3009055 SHV-236 ARO:3009055 SHV-236 Class A beta-lactamase SHV-237. SHV-237 antibiotic_resistance ARO:3009056 SHV-237 ARO:3009056 SHV-237 Inhibitor-resistant extended-spectrum class A beta-lactamase SHV-238. SHV-238 antibiotic_resistance ARO:3009057 SHV-238 ARO:3009057 SHV-238 Inhibitor-resistant class A beta-lactamase SHV-239. SHV-239 antibiotic_resistance ARO:3009058 SHV-239 ARO:3009058 SHV-239 Inhibitor-resistant class A beta-lactamase SHV-240. SHV-240 antibiotic_resistance ARO:3009059 SHV-240 ARO:3009059 SHV-240 Inhibitor-resistant class A beta-lactamase SHV-241. SHV-241 antibiotic_resistance ARO:3009060 SHV-241 ARO:3009060 SHV-241 Inhibitor-resistant class A beta-lactamase SHV-242. SHV-242 antibiotic_resistance ARO:3009061 SHV-242 ARO:3009061 SHV-242 Class A beta-lactamase SHV-243. SHV-243 antibiotic_resistance ARO:3009062 SHV-243 ARO:3009062 SHV-243 Class A beta-lactamase SHV-244. SHV-244 antibiotic_resistance ARO:3009063 SHV-244 ARO:3009063 SHV-244 Class A beta-lactamase SHV-245. SHV-245 antibiotic_resistance ARO:3009064 SHV-245 ARO:3009064 SHV-245 Class C beta-lactamase SRT-4. SRT-4 antibiotic_resistance ARO:3009065 SRT-4 ARO:3009065 SRT-4 Class A beta-lactamase TEM-239. TEM-239 antibiotic_resistance ARO:3009066 TEM-239 ARO:3009066 TEM-239 Class A beta-lactamase TEM-248. TEM-248 antibiotic_resistance ARO:3009067 TEM-248 ARO:3009067 TEM-248 Class A beta-lactamase TEM-249. TEM-249 antibiotic_resistance ARO:3009068 TEM-249 ARO:3009068 TEM-249 Class A beta-lactamase TEM-250. TEM-250 antibiotic_resistance ARO:3009069 TEM-250 ARO:3009069 TEM-250 Class A beta-lactamase TEM-251. TEM-251 antibiotic_resistance ARO:3009070 TEM-251 ARO:3009070 TEM-251 Class A beta-lactamase TEM-252. TEM-252 antibiotic_resistance ARO:3009071 TEM-252 ARO:3009071 TEM-252 Class A beta-lactamase TEM-253. TEM-253 antibiotic_resistance ARO:3009072 TEM-253 ARO:3009072 TEM-253 Class A beta-lactamase TEM-254. TEM-254 antibiotic_resistance ARO:3009073 TEM-254 ARO:3009073 TEM-254 Class A beta-lactamase TEM-255. TEM-255 antibiotic_resistance ARO:3009074 TEM-255 ARO:3009074 TEM-255 Class A beta-lactamase TEM-256. TEM-256 antibiotic_resistance ARO:3009075 TEM-256 ARO:3009075 TEM-256 Class A beta-lactamase TEM-257. TEM-257 antibiotic_resistance ARO:3009076 TEM-257 ARO:3009076 TEM-257 Class A beta-lactamase TEM-258. TEM-258 antibiotic_resistance ARO:3009077 TEM-258 ARO:3009077 TEM-258 Extended-spectrum class A beta-lactamase VEB-16. antibiotic_resistance ARO:3009078 VEB-16dep ARO:3009078 Extended-spectrum class A beta-lactamase VEB-18. VEB-18 antibiotic_resistance ARO:3009079 VEB-18 ARO:3009079 VEB-18 Extended-spectrum class A beta-lactamase VEB-28. VEB-28 antibiotic_resistance ARO:3009080 VEB-28 ARO:3009080 VEB-28 Extended-spectrum class A beta-lactamase VEB-29. VEB-29 antibiotic_resistance ARO:3009081 VEB-29 ARO:3009081 VEB-29 Extended-spectrum class A beta-lactamase VEB-30. VEB-30 antibiotic_resistance ARO:3009082 VEB-30 ARO:3009082 VEB-30 Extended-spectrum class A beta-lactamase VEB-31. VEB-31 antibiotic_resistance ARO:3009083 VEB-31 ARO:3009083 VEB-31 Extended-spectrum class A beta-lactamase VEB-32. VEB-32 antibiotic_resistance ARO:3009084 VEB-32 ARO:3009084 VEB-32 Extended-spectrum class A beta-lactamase VEB-33. VEB-33 antibiotic_resistance ARO:3009085 VEB-33 ARO:3009085 VEB-33 Extended-spectrum class A beta-lactamase VEB-34. VEB-34 antibiotic_resistance ARO:3009086 VEB-34 ARO:3009086 VEB-34 Extended-spectrum class A beta-lactamase VEB-35. VEB-35 antibiotic_resistance ARO:3009087 VEB-35 ARO:3009087 VEB-35 Extended-spectrum class A beta-lactamase VEB-36. VEB-36 antibiotic_resistance ARO:3009088 VEB-36 ARO:3009088 VEB-36 Extended-spectrum class A beta-lactamase VEB-37. VEB-37 antibiotic_resistance ARO:3009089 VEB-37 ARO:3009089 VEB-37 Extended-spectrum class A beta-lactamase VEB-38. VEB-38 antibiotic_resistance ARO:3009090 VEB-38 ARO:3009090 VEB-38 Extended-spectrum class A beta-lactamase VEB-39. VEB-39 antibiotic_resistance ARO:3009091 VEB-39 ARO:3009091 VEB-39 Subclass B1 metallo-beta-lactamase VIM-88. VIM-88 antibiotic_resistance ARO:3009092 VIM-88 ARO:3009092 VIM-88 Subclass B1 metallo-beta-lactamase VIM-89. VIM-89 antibiotic_resistance ARO:3009093 VIM-89 ARO:3009093 VIM-89 Subclass B1 metallo-beta-lactamase VIM-90. VIM-90 antibiotic_resistance ARO:3009094 VIM-90 ARO:3009094 VIM-90 Subclass B1 metallo-beta-lactamase VIM-91. VIM-91 antibiotic_resistance ARO:3009095 VIM-91 ARO:3009095 VIM-91 Class C beta-lactamase YOC-1. YOC-1 antibiotic_resistance ARO:3009096 YOC-1 ARO:3009096 YOC-1 Subclass B1 metallo-beta-lactamase CfiA28. CfiA28 antibiotic_resistance ARO:3009098 CfiA28 ARO:3009098 CfiA28 Subclass B1 metallo-beta-lactamase CfiA29. CfiA29 antibiotic_resistance ARO:3009099 CfiA29 ARO:3009099 CfiA29 Subclass B1 metallo-beta-lactamase CfiA30. CfiA30 antibiotic_resistance ARO:3009100 CfiA30 ARO:3009100 CfiA30 Subclass B1 metallo-beta-lactamase CfiA31. CfiA31 antibiotic_resistance ARO:3009101 CfiA31 ARO:3009101 CfiA31 First-generation cephalosporin antibiotics include those with a relatively narrow spectrum of activity, primarily effective against gram-positive cocci and with minimal coverage against gram-negative bacteria. 1st-generation cephalosporin antibiotic_resistance ARO:3009105 first-generation cephalosporin ARO:3009105 Second-generation cephalosporin antibiotics have increased efficacy against gram-negative bacteria compared to first-generation cephalosporins. This subclass also includes cephamycin antibiotics. 2nd-generation cephalosporin antibiotic_resistance ARO:3009106 second-generation cephalosporin ARO:3009106 Third generation cephalosporin antibiotics have a marked activity against gram-negative bacteria, but diminished activity against gram-positive bacteria. 3rd-generation cephalosporin antibiotic_resistance ARO:3009107 third-generation cephalosporin ARO:3009107 Fourth-generation cephalosporins have activity against gram-positive cocci and a broad array of gram-negative bacteria, including Pseudomonas and many of the Enterobacteriaceae with inducible chromosomal beta-lactamases. 4th-generation cephalosporin antibiotic_resistance ARO:3009108 fourth-generation cephalosporin ARO:3009108 This subfamily includes other penem and cephalosporin antibiotics without defined classification by generation. antibiotic_resistance ARO:3009109 other cephalosporins and penems ARO:3009109 Cefazedone is a semisynthetic first-generation cephalosporin with antibacterial activity. Cefazedone binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. CAS:56187-47-4 ChEBI:131731 ChEMBL:CHEMBL2107636 PubChem:71736 antibiotic_resistance ARO:3009110 cefazedone ARO:3009110 Cefatrizine is a broad-spectrum, semisynthetic, first-generation cephalosporin with antibacterial activity. Cefatrizine binds to and inactivates penicillin-binding proteins located on the inner membrane of the bacterial cell wall causing cell lysis. CAS:51627-14-6 ChEBI:131730 ChEMBL:CHEMBL1095284 PubChem:6410758 antibiotic_resistance ARO:3009111 cefatrizine ARO:3009111 Cefacetrile is a broad-spectrum first-generation cephalosporin with antibacterial activity. Cefacetrile binds to and inactivates penicillin-binding proteins located on the inner membrane of the bacterial cell wall causing cell lysis. CAS:10206-21-0 ChEBI:135437 ChEMBL:CHEMBL2110602 PubChem:91562 cephacetrile antibiotic_resistance ARO:3009112 cefacetrile ARO:3009112 Cefroxadine is a semisynthetic first-generation cephalosporin with antibacterial activity. Cefroxadine binds to and inactivates penicillin-binding proteins located on the inner membrane of the bacterial cell wall causing cell lysis. CAS:51762-05-1 ChEBI:31379 ChEMBL:CHEMBL3186538 PubChem:5284529 cephroxadine antibiotic_resistance ARO:3009113 cefroxadine ARO:3009113 Ceftezole is a first-generation cephalosporin antibiotic with antibacterial activity. Ceftezole binds to and inactivates penicillin-binding proteins located on the inner membrane of the bacterial cell wall causing cell lysis. It is a cephalosporin and a thiadiazole. CAS:26973-24-0 ChEBI:135716 ChEMBL:CHEMBL1697829 PubChem:65755 cephtezole antibiotic_resistance ARO:3009114 ceftezole ARO:3009114 Ceforanide is a second-generation cephalosporin antibiotic. It is effective against many coliforms, including Escherichia coli, Klebsiella, Enterobacter and Proteus, and most strains of Salmonella, Shigella, Hemophilus, Citrobacter species. CAS:60925-61-3 ChEBI:3495 ChEMBL:CHEMBL1201046 PubChem:43507 cephoranide antibiotic_resistance ARO:3009115 ceforanide ARO:3009115 Cefminox is a second-generation cephalosporin and cephamycin antibiotic. It has broad-spectrum activity, and is especially effective against Gram-negative and anaerobic bacteria. CAS:84305-41-9 ChEBI:135817 ChEMBL:CHEMBL1276342 PubChem:71141 cephminox antibiotic_resistance ARO:3009116 cefminox ARO:3009116 Cefbuperazone is a second-generation cephalosporin and cephamycin antibiotic. CAS:76610-84-9 ChEBI:135856 ChEMBL:CHEMBL1908372 PubChem:127527 antibiotic_resistance ARO:3009117 cefbuperazone ARO:3009117 Cefmenoxime is a broad-spectrum and third-generation cephalosporin antibiotic that is typically used in the treatment of female gynecologic and obstetric infections. It is reported to exhibit high activity against a wide variety of gram-positive and gram-negative bacteria. CAS:65085-01-0 ChEBI:55490 ChEMBL:CHEMBL1201224 PubChem:9570757 antibiotic_resistance ARO:3009118 cefmenoxime ARO:3009118 Cefodizime is a third-generation, aminothiazolyl cephalosporin for parenteral use. Cefodizime has broad-spectrum activity and is stable to most beta-lactamases. CAS:69739-16-8 ChEBI:63214 ChEMBL:CHEMBL2303613 PubChem:5361871 cephodizime antibiotic_resistance ARO:3009119 cefodizime ARO:3009119 Cefpiramide is a third-generation cephalosporin antibiotic. CAS:70797-11-4 ChEBI:59213 ChEMBL:CHEMBL1201204 PubChem:636405 antibiotic_resistance ARO:3009120 cefpiramide ARO:3009120 Cefteram is a third-generation cephalosporin antibiotic compound. CAS:82547-58-8 ChEBI:135776 ChEMBL:CHEMBL2105953 PubChem:6537431 antibiotic_resistance ARO:3009121 cefteram ARO:3009121 Cefozopran is a fourth-generation cephalosporin antibiotic with broad-spectrum activity. CAS:113359-04-9 ChEBI:3502 ChEMBL:CHEMBL1276663 PubChem:9571080 cephozopran antibiotic_resistance ARO:3009122 cefozopran ARO:3009122 Pencillin-like antibiotics with extended spectrum activity gram-negative bacteria, such as ampicillin and similar antibiotic compounds. antibiotic_resistance ARO:3009123 penicillin with extended spectrum ARO:3009123 Pencillin-like beta-lactam antibiotics with narrow spectrum activity against beta-lactam susceptible bacteria. antibiotic_resistance ARO:3009124 beta-lactamase sensitive penicillin ARO:3009124 Penicillin-like antibiotic compounds resistant to penicillinase activity. antibiotic_resistance ARO:3009125 beta-lactamase resistant penicillin ARO:3009125 Azidocillin is a narrow-spectrum, semisynthetic penicillin derivative with antibacterial activity. CAS:17243-38-8 ChEBI:51758 ChEMBL:CHEMBL2105907 PubChem:15574941 antibiotic_resistance ARO:3009126 azidocillin ARO:3009126 Phenethicillin is a penicillin in which the substituent at position 6 of the penam ring is a 2-phenoxypropanamido group. It is a penicillin compound with antibacterial activity. CAS:147-55-7 ChEBI:52427 ChEMBL:CHEMBL1614637 PubChem:272833 antibiotic_resistance ARO:3009127 Phenethicillin ARO:3009127 Penamecillin is a semisynthetic derivative penicillanic acid ester that is the acetoxymethyl ester of benzylpenicillin. It is a prodrug for benzylpenicillin with antibacterial activity. CAS:983-85-7 ChEBI:131733 ChEMBL:CHEMBL2106988 PubChem:10250769 antibiotic_resistance ARO:3009128 penamecillin ARO:3009128 Clometocillin is a penicillin that is benzylpenicillin in which the phenylacetyl group has been replaced by a (3,4-dichlorophenyl)(methoxy)acetyl group. It is a semisynthetic penicillin derivative with antibacterial activity. CAS:1926-49-4 ChEBI:131732 ChEMBL:CHEMBL2106548 PubChem:71807 antibiotic_resistance ARO:3009129 clometocillin ARO:3009129 Pivampicillin is a semisynthetic, orally active pivalate ester of ampicillin with antibacterial activity. CAS:33817-20-8 ChEBI:8255 ChEMBL:CHEMBL3182343 PubChem:33478 antibiotic_resistance ARO:3009130 pivampicillin ARO:3009130 Epicillin is an extended-spectrum, semisynthetic aminopenicillin with antibacterial activity. CAS:26774-90-3 ChEBI:58974 ChEMBL:CHEMBL2104266 PubChem:71392 dexacillin antibiotic_resistance ARO:3009131 epicillin ARO:3009131 Hetacillin is a semi-synthetic penicillin compound with bactericidal properties. Hetacillin is a prodrug that is converted to ampicillin via esterases. CAS:3511-16-8 ChEBI:5683 ChEMBL:CHEMBL1201116 PubChem:443387 antibiotic_resistance ARO:3009132 hetacillin ARO:3009132 Aspoxicillin is a broad-spectrum, semisynthetic penicillin derivative with antibacterial activity. CAS:63358-49-6 ChEBI:31240 ChEMBL:CHEMBL1318150 PubChem:71961 antibiotic_resistance ARO:3009133 aspoxicillin ARO:3009133 MSH2 is a mismatch repair gene in fungi. Strains with alterations in this gene exhibit the resistance to Polyenes (Amphotericin B), Echinocandins (Caspofungin, Micafungin), and Azoles (Fluconazole, Voriconazole). antibiotic_resistance ARO:3009134 antifungal resistance-associated MSH2 ARO:3009134 MSH2 is a mismatch repair gene in fungi. Strains with alterations in this gene exhibit the resistance to Polyenes (Amphotericin B), Echinocandins (Caspofungin, Micafungin), and Azoles (Fluconazole, Voriconazole). PMID:27020939 The Antibiotic Resistance Platform (ARP) is a cell-based array of mechanistically distinct individual resistance elements in an identical genetic background. The ARP consists of resistance elements to 18 classes of antibiotics. There are over 100 antibiotic resistance genes currently in the ARP. https://www.thewrightlab.com/antibiotic-resistance-platform. antibiotic_resistance ARO:3009135 Antibiotic Resistance Platform (ARP) ARO:3009135 The Antibiotic Resistance Platform (ARP) is a cell-based array of mechanistically distinct individual resistance elements in an identical genetic background. The ARP consists of resistance elements to 18 classes of antibiotics. There are over 100 antibiotic resistance genes currently in the ARP. https://www.thewrightlab.com/antibiotic-resistance-platform. PMID:28017602 PMID:31680676 The Minimal Antibiotic Resistance Platform (mARP) is a tool that can be used for the general dereplication of antibiotics in natural product extracts. This platform consists of fifteen low-copy number plasmids that constitutively express individual resistance genes that target seventeen of the most commonly found antibiotics. This kit is useful for antibiotic dereplication and adjuvant discovery. https://www.thewrightlab.com/antibiotic-resistance-platform. antibiotic_resistance ARO:3009136 Minimal Antibiotic Resistance Platform (mARP) ARO:3009136 The Minimal Antibiotic Resistance Platform (mARP) is a tool that can be used for the general dereplication of antibiotics in natural product extracts. This platform consists of fifteen low-copy number plasmids that constitutively express individual resistance genes that target seventeen of the most commonly found antibiotics. This kit is useful for antibiotic dereplication and adjuvant discovery. https://www.thewrightlab.com/antibiotic-resistance-platform. PMID:28017602 PMID:31680676 A biocurator is a scientist who extracts, interprets, synthesizes and archives data from a variety of sources, including literature, genomes, online materials and author provided biological data, to standardize this data and make it machine readable, more discoverable and accessible to the public. Reproduced from the International Society for Biocuration: https://www.biocuration.org/community/biocuration-generic-job-description/. antibiotic_resistance ARO:3009137 Biocurator ARO:3009137 A biocurator is a scientist who extracts, interprets, synthesizes and archives data from a variety of sources, including literature, genomes, online materials and author provided biological data, to standardize this data and make it machine readable, more discoverable and accessible to the public. Reproduced from the International Society for Biocuration: https://www.biocuration.org/community/biocuration-generic-job-description/. PMID:22434828 PMID:38271296 5-Fluorouracil (5FU) is an antimetabolite typically used as a cancer treatment and is cytotoxic. It is a pyrimidine analogue inhibits thymidylate synthase which halts the DNA synthesis. Its cytotoxic effects on eukaryotic cells have also allowed the drug to be explored for fungal infection treatment as well. antibiotic_resistance ARO:3009138 5-Fluorouracil ARO:3009138 Resistance in Mycobacterium tuberculosis is almost exclusively SNVs. Unlike other organisms, culture and antibiotic susceptibility testing for TB is very challenging. The TB community instead developed a likelihood framework, based on statistical association of SNVs with observed phenotypic resistance across a large number of sequenced genomes, organized as mutation catalogs. It is important to note that each catalog may recycle data from earlier catalogs. antibiotic_resistance ARO:3009139 Mycobacterium tuberculosis mutation catalog ARO:3009139 The Relational Sequencing Tuberculosis Data platform (ReSeqTB) is a Mycobacterium tuberculosis AMR mutation catalog published in 2018. Mutation data acquired from the ReSeqTB catalog are evaluated as conferring resistance (Minimal, Moderate, High), not conferring resistance (None), or Indeterminate. ReSeqTB-High ReSeqTB-Indeterminate ReSeqTB-Minimal ReSeqTB-Moderate ReSeqTB-None antibiotic_resistance ARO:3009140 ReSeqTB ARO:3009140 The Relational Sequencing Tuberculosis Data platform (ReSeqTB) is a Mycobacterium tuberculosis AMR mutation catalog published in 2018. Mutation data acquired from the ReSeqTB catalog are evaluated as conferring resistance (Minimal, Moderate, High), not conferring resistance (None), or Indeterminate. PMID:30337678 The Comprehensive Resistance Prediction for Tuberculosis: an International Consortium (CRyPTIC) is a Mycobacterium tuberculosis AMR mutation catalog published in 2022. Mutation data acquired from the CRyPTIC catalog are evaluated as resistant (R), susceptible (S), or undetermined (U). CRyPTIC-R CRyPTIC-S CRyPTIC-U antibiotic_resistance ARO:3009141 CRyPTIC ARO:3009141 The Comprehensive Resistance Prediction for Tuberculosis: an International Consortium (CRyPTIC) is a Mycobacterium tuberculosis AMR mutation catalog published in 2022. Mutation data acquired from the CRyPTIC catalog are evaluated as resistant (R), susceptible (S), or undetermined (U). PMID:35944069 The World Health Organization (WHO) Mutation Catalog, Second Edition is a Mycobacterium tuberculosis AMR mutation catalog published in 2023. https://www.who.int/publications/i/item/9789240082410. Mutation data acquired from the WHO 2023 catalog are evaluated as resistant (R), susceptible (S), or undetermined (U). WHO-R WHO-S WHO-U antibiotic_resistance ARO:3009142 WHO TB mutation catalog, Second Edition ARO:3009142 The World Health Organization (WHO) Mutation Catalog, Second Edition is a Mycobacterium tuberculosis AMR mutation catalog published in 2023. https://www.who.int/publications/i/item/9789240082410. Mutation data acquired from the WHO 2023 catalog are evaluated as resistant (R), susceptible (S), or undetermined (U). ISBN:978-92-4-008241-0 Mutation data hand curated from the scientific literature, evaluated as conferring resistance (R). antibiotic_resistance ARO:3009143 Curated-R ARO:3009143 MexAB is a multidrug efflux pump complex consisting of Mex A and Mex B, two primary components. Forming the core transport machinery that can interface with various outer membrane proteins to expel antibiotics and toxic compounds, contributing to multidrug resistance. This component can be paired with OprM. antibiotic_resistance ARO:3009144 MexAB ARO:3009144 MexCD is a multidrug efflux pump complex composed of Mex C and Mex D as its primary components. This system forms the central transport mechanism, capable of interacting with diverse outer membrane proteins to eject antibiotics and toxic substances, thus playing a significant role in multidrug resistance. antibiotic_resistance ARO:3009145 MexCD ARO:3009145 MexEF is a multidrug efflux pump complex comprising MexE and MexF as its core components. This system functions as the primary transport mechanism, interacting with various outer membrane proteins to expel antibiotics and harmful compounds, thus contributing to multidrug resistance. antibiotic_resistance ARO:3009146 MexEF ARO:3009146 MexGHI is a multidrug efflux pump complex consisting of MexG, MexH, and MexI as its key components. Together, they form a central transport system that interfaces with outer membrane proteins to remove antibiotics and toxic substances, playing a role in multidrug resistance. antibiotic_resistance ARO:3009147 MexGHI ARO:3009147 The MexJK efflux pump system in Pseudomonas aeruginosa is unique in that it can function independently of an outer membrane protein (OMP), distinguishing it from many other efflux systems. MexJK is a multidrug efflux pump complex composed of MexJ and MexK as its primary components. This system serves as a core transport mechanism, working with outer membrane proteins to expel antibiotics and harmful compounds, thereby contributing to multidrug resistance. antibiotic_resistance ARO:3009148 MexJK ARO:3009148 The MexJK efflux pump system in Pseudomonas aeruginosa is unique in that it can function independently of an outer membrane protein (OMP), distinguishing it from many other efflux systems. MexJK is a multidrug efflux pump complex composed of MexJ and MexK as its primary components. This system serves as a core transport mechanism, working with outer membrane proteins to expel antibiotics and harmful compounds, thereby contributing to multidrug resistance. PMID:12193619 MexMN is a multidrug efflux pump complex consisting of MexM and MexN as its main components. This system acts as a central transport mechanism, partnering with outer membrane proteins to expel antibiotics and toxic compounds, thereby playing a significant role in multidrug resistance. antibiotic_resistance ARO:3009149 MexMN ARO:3009149 MexPQ is a multidrug efflux pump complex comprising MexP and MexQ as its primary components. This system functions as a core transport mechanism, interacting with outer membrane proteins to expel antibiotics and toxic substances, contributing to multidrug resistance. antibiotic_resistance ARO:3009150 MexPQ ARO:3009150 MexVW is a multidrug efflux pump complex composed of MexV and MexW as its main components. This system operates as a central transport mechanism, associating with outer membrane proteins to expel antibiotics and toxic compounds, thereby playing a role in multidrug resistance. antibiotic_resistance ARO:3009151 MexVW ARO:3009151 MexXY is a multidrug efflux pump complex consisting of MexX and MexY as its core components. This system serves as a key transport mechanism, interacting with outer membrane proteins to expel antibiotics and toxic compounds, contributing to multidrug resistance. antibiotic_resistance ARO:3009152 MexXY ARO:3009152 MexHI-OpmD is a multidrug efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexH is the membrane fusion protein, MexI is the inner membrane resistance-nodulation-cell division (RND) transporter, and OpmD is the outer membrane factor protein. antibiotic_resistance ARO:3009153 MexHI-OpmD ARO:3009153 MexHI-OpmD is a multidrug efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexH is the membrane fusion protein, MexI is the inner membrane resistance-nodulation-cell division (RND) transporter, and OpmD is the outer membrane factor protein. PMID:12937010 Naphthoquinones constitute a class of organic compounds structurally related to naphthalene. antibiotic_resistance ARO:3009154 napthoquinone antibiotics ARO:3009154 Atovaquone is an antimicrobial medication for the prevention and treatment of Pneumocystis jirovecii pneumonia (PCP). It is a naphthoquinone compound having a 4-(4-chlorophenyl)cyclohexyl group at the 2-position and a hydroxy substituent at the 3-position. CAS:95233-18-4 ChEBI:575568 ChEMBL:CHEMBL1450 PubChem:74989 antibiotic_resistance ARO:3009155 atovaquone ARO:3009155 Atovaquone is an antimicrobial medication for the prevention and treatment of Pneumocystis jirovecii pneumonia (PCP). It is a naphthoquinone compound having a 4-(4-chlorophenyl)cyclohexyl group at the 2-position and a hydroxy substituent at the 3-position. PMID:12936966 Neutramycin is a macrolide first identified from S. rimosus and S. luteoverticillatus. ChEMBL:CHEMBL3989795 PubChem:6445534 antibiotic_resistance ARO:3009156 neutramycin ARO:3009156 Neutramycin is a macrolide first identified from S. rimosus and S. luteoverticillatus. PMID:14274934 PMID:14510587 PMID:27199910 PMID:5766558 PMID:5870757 A proposed grammar to describe genetic changes that is readable by both human and code (https://fowlerlab.org/2018/11/25/goarc-a-general-ontology-for-antimicrobial-resistance-catalogues). antibiotic_resistance ARO:3009157 Grammar for Antimicrobial Resistance Catalogues (GARC) ARO:3009157 The HGVS Nomenclature is an internationally-recognized standard for the description of DNA, RNA, and protein sequence variants. It is used to convey variants in clinical reports and to share variants in publications and databases (https://hgvs-nomenclature.org/stable). antibiotic_resistance ARO:3009158 Human Genome Variation Society (HGVS) Nomenclature ARO:3009158 The HGVS Nomenclature is an internationally-recognized standard for the description of DNA, RNA, and protein sequence variants. It is used to convey variants in clinical reports and to share variants in publications and databases (https://hgvs-nomenclature.org/stable). PMID:26931183 PMID:39702242 Antifungal compound typically used to treat skin infections. CAS:60628-96-8 ChEBI:78692 ChEMBL:CHEMBL277535 PubChem:2378 antibiotic_resistance ARO:3009159 Bifonazole ARO:3009159 Antifungal compound typically used to treat skin infections. PMID:27799210 An antifungal compound that is converted into fluorouracil inside cells, thereby impairing the synthesis of proteins and DNA. This drug should almost always be used in combination with amphotericin B for systemic fungal infections, but the ratio is important since flucytosine can increase the toxicity of amphotericin B and vice versa. Flucytosine is typically indicated for Candida and Cryptococcus infections. CAS:2022-85-7 ChEBI:5100 ChEMBL:CHEMBL1463 PubChem:3366 antibiotic_resistance ARO:3009160 5-fluorocytosine ARO:3009160 A foliar fungicide used to control a wide range of Ascomycetes and Fungi Imperfecti in a wide range of crops. antibiotic_resistance ARO:3009161 benomyl ARO:3009161 A foliar fungicide used to control a wide range of Ascomycetes and Fungi Imperfecti in a wide range of crops. PMID:34152819 This compound is a small molecule antifungal drug with a maximum clinical trial phase of II. The compound inhibits 14a demethylase, an enzyme involved in sterol synthesis, resulting in lysis of the fungal cell wall and fungal cell death. antibiotic_resistance ARO:3009162 Ravuconazole ARO:3009162 This compound is a small molecule antifungal drug with a maximum clinical trial phase of II. The compound inhibits 14a demethylase, an enzyme involved in sterol synthesis, resulting in lysis of the fungal cell wall and fungal cell death. PMID:18775650 Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR). DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins. It is typically used in combination with other drugs to treat parasitic infections, including malaria and toxoplasmosis. When combined with sulfadoxine, it can be used as prophylaxis for Pneumocystis jerovecii (fungi) induced pneumonia (PCP). However, this compound is generally not recommended for PCP prophylaxis unless trimethoprim-sulfamethoxazole, pentamidine, dapsone/pyrimethamine/leucovorin, atovaquone or dapsone cannot be used. CAS:58-14-0 ChEBI:8673 ChEMBL:CHEMBL36 PubChem:4993 antibiotic_resistance ARO:3009163 pyrimethamine ARO:3009163 A fungicide used for control of powdery mildew, scab and other fungal pathogens on a range of crops. Resistance was noted by Penicillium digitatum. CAS:88283-41-4 ChEBI:81972 PubChem:55790 antibiotic_resistance ARO:3009164 pyrifenox ARO:3009164 A fungicide used for control of powdery mildew, scab and other fungal pathogens on a range of crops. Resistance was noted by Penicillium digitatum. PMID:10919801 Antifungal compounds with multiple applications and usages, including antimalarial, anti-cancer, anti-protist, etc. Often include ambiguous drug family classification. antibiotic_resistance ARO:3009165 antifungal without defined classification ARO:3009165 This compound is used to control a number of cereal fungal pathogens including those belonging to the Ascomycetes, Basidiomycetes and Zygomycetes families. antibiotic_resistance ARO:3009166 fluxapyroxad ARO:3009166 A fungicide seed treatment for control of a range of diseases including Fusarium, Rhizoctonia and Alternaria. It has a role as an androgen antagonist, an estrogen receptor agonist and an antifungal agrochemical. It was noted as being the only fungicide still providing protection against multirestitant fungi. CAS:131341-86-1 ChEBI:191042 ChEMBL:CHEMBL485833 PubChem:86398 antibiotic_resistance ARO:3009167 fludioxinil ARO:3009167 A persisent and broad spectrum fungicide used for the control of Septoria tritici, rusts and other diseases in cereals and some other crops. It is tied to causing cancer. CAS:881685-58-1 ChEBI:83126 PubChem:25271089 antibiotic_resistance ARO:3009168 isopyrazam ARO:3009168 A persisent and broad spectrum fungicide used for the control of Septoria tritici, rusts and other diseases in cereals and some other crops. It is tied to causing cancer. PMID:35973770 This compound inhibits sterol 14alpha-demethylase and is used as a fungicide for the control of powdery mildew, scab and other diseases on a variety of crops. It is a member of the following groups: monochlorobenzenes, imidazoles, (trifluoromethyl)benzenes, carboxamidine, ether and conazoles. antibiotic_resistance ARO:3009169 triflumizole ARO:3009169 This compound inhibits sterol 14alpha-demethylase and is used as a fungicide for the control of powdery mildew, scab and other diseases on a variety of crops. It is a member of the following groups: monochlorobenzenes, imidazoles, (trifluoromethyl)benzenes, carboxamidine, ether and conazoles. PMID:10919801 This chemical compound is produced by the myxobacterium Myxococcus fulvus. It is an inhibitor of the mitochondrial cytochrome bc1 complex (coenzyme Q - cytochrome c reductase). It is a competitive inhibitor of ubiquinol, and binds at the quinol oxidation (Qo) site of the bc1 complex, blocking electron transfer to the Rieske iron-sulfur protein. antibiotic_resistance ARO:3009170 myxothiazole ARO:3009170 An agricultural fungicide that inhibits the pathway leading to the synthesis of ergosterol. CAS:134074-64-9 ChEBI:83832 PubChem:11348992 antibiotic_resistance ARO:3009171 oxpoconazole ARO:3009171 An agricultural fungicide that inhibits the pathway leading to the synthesis of ergosterol. PMID:12324349 This compound inhibits 1,3-beta-glucan synthase in fungi (primarily yeasts), which is a major compound of cell wall synthesis. ChEBI:217490 PubChem:9941831 antibiotic_resistance ARO:3009172 arborcandin C ARO:3009172 This is a Benzylamine Antifungal which is believed to inhibit the squalene epoxidase enzyme that is essential in the formation of sterols necessary for fungal cell membranes. It is typically used in the treatment of dermatological infections. Butenafine is trimethylamine in which hydrogen atoms attached to different methyl groups are substituted by 1-naphthyl and 4-tert-butylphenyl groups. It is a tertiary amine and a member of naphthalenes. CAS:101828-21-1 ChEBI:3238 ChEMBL:CHEMBL990 PubChem:2484 antibiotic_resistance ARO:3009173 butenafine ARO:3009173 Tolnaftate is a synthetic over-the-counter antifungal which may come as a cream, powder, spray or liquid aerosol typically used to treat jock itch, athlete's foot and ringworm. It is a monothiocarbamic ester that is the methyl(3-tolyl)carbamothioate ester of 2-naphthol. CAS:2398-96-1 ChEBI:9620 ChEMBL:CHEMBL83668 PubChem:5510 antibiotic_resistance ARO:3009174 tolnaftate ARO:3009174 As a fungicide, carbendazim controls Ascomycetes, Fungi Imperfecti, and Basidiomycetes on a wide variety of crops. It also has a role as an antinematodal drug, a metabolite, a microtubule-destabilising agent. Carbendazim is a member of the class of benzimidazoles that is 2-aminobenzimidazole in which the primary amino group is substituted by a methoxycarbonyl group. It is a carbamate ester and a benzimidazolylcarbamate fungicide. It is functionally related to a 2-aminobenzimidazole. Additionally, Carbendazim has been used in cancer trials studying the treatment of Lymphoma and Unspecified Adult Solid Tumor, Protocol Specific. CAS:10605-21-7 ChEBI:3392 ChEMBL:CHEMBL70971 PubChem:25429 antibiotic_resistance ARO:3009175 carbendazim ARO:3009175 A metabolite from Penicillium brefeldianum that exhibits a wide range of antibiotic activity, including antifungal functionality. It also has a role as a Penicillium metabolite. CAS:20350-15-6 ChEBI:48080 ChEMBL:CHEMBL19980 PubChem:5287620 antibiotic_resistance ARO:3009176 brefeldin A ARO:3009176 Cerulenin has a role as an antifungal agent, an antiinfective agent, an antilipemic drug, an antimetabolite, a fatty acid synthesis inhibitor and an antimicrobial agent. It functions by inhibiting the biosynthesis of several lipids and sterols by interfering with enzyme function. In fatty acid synthesis, it is reported to bind in equimolar ratio to b-keto-acyl-ACP synthase. In sterol synthesis, it inhibits HMG-CoA synthetase activity. It is a monocarboxylic acid amide and an epoxide and is found naturally in several species including Cephalosporium caerulensfungus, Euglena gracilis, Acremonium, Acrocylindrum and Helicoceras. It is also shown to inhibit feeding and induce dramatic weight loss in mice. CAS:17397-89-6 ChEBI:171741 ChEMBL:CHEMBL45627 PubChem:5282054 antibiotic_resistance ARO:3009177 cerulenin ARO:3009177 Diamide is primarily used as an insecticide with evidence of mammalian toxicity. This compound is chemically classified as being part of the monoazo group. FungAMR listed this compound as having some anti-fungal properties. CAS:10465-78-8 ChEBI:48958 ChEMBL:CHEMBL1255835 PubChem:5353800 antibiotic_resistance ARO:3009178 diamide ARO:3009178 Diethofencarb is a fungicide typically used as an agrochemical. It is shown to have strong activity against Botrytis cinerea and benzimidazole-resistant strains of Botryis spp. It is a carbamate ester class fungicide, an aromatic ether and a carbanilate fungicide (subclass of carbamate fungicide). It is functionally related to an aniline. CAS:87130-20-9 ChEBI:4520 ChEMBL:CHEMBL1880404 PubChem:91742 antibiotic_resistance ARO:3009179 diethofencarb ARO:3009179 An agricultural fungicide that is a systemic conazole (imidazole) fungicide used for the control of many seed-borne and soil-borne diseases and fungi particularly Ascomycetes and Basidiomycetes. It has a broad spectrum of action, being systemic with protective and curative action, but is known to disrupt membrane function. It also has a role as a chelator. It is a tertiary alcohol, a member of triazoles and a dichlorobenzene. In FungAMR, it was listed as having effects against Aspergillus fumigatus. It is commonly used in the control of apple, coffee and peanut diseases, but is also used for various other fruits and vegetables. Major consumption is in Asian countries and it is used mainly for the control of rice sheath blight in China, India, Vietnam, and parts of East Asia. It was introduced in the 1980s, it is not approved for use within the European Union. CAS:79983-71-4 ChEBI:83711 ChEMBL:CHEMBL1898860 PubChem:66461 antibiotic_resistance ARO:3009180 hexaconazole ARO:3009180 An agricultural fungicide that is a systemic conazole (imidazole) fungicide used for the control of many seed-borne and soil-borne diseases and fungi particularly Ascomycetes and Basidiomycetes. It has a broad spectrum of action, being systemic with protective and curative action, but is known to disrupt membrane function. It also has a role as a chelator. It is a tertiary alcohol, a member of triazoles and a dichlorobenzene. In FungAMR, it was listed as having effects against Aspergillus fumigatus. It is commonly used in the control of apple, coffee and peanut diseases, but is also used for various other fruits and vegetables. Major consumption is in Asian countries and it is used mainly for the control of rice sheath blight in China, India, Vietnam, and parts of East Asia. It was introduced in the 1980s, it is not approved for use within the European Union. PMID:24084639 An agricultural fungicide that is a member of the triazole antifungal class. CAS:107534-96-3 ChEBI:83779 ChEMBL:CHEMBL487186 PubChem:86102 antibiotic_resistance ARO:3009181 tebuconazole ARO:3009181 An agricultural fungicide that is a member of the triazole antifungal class. PMID:32186508 A fungicide that is used commercially for agriculture. It is also used in combination with permethrin in formulations of wood preserver. The compound is known as a DMI, or demethylation inhibiting fungicide, due to its binding with and inhibition of the 14-alpha demethylase enzyme from demethylating a precursor to ergosterol. Without this demethylation step, the ergosterols are not incorporated into the growing fungal cell membranes, and cellular growth is stopped. CAS:60207-90-1 ChEBI:8489 ChEMBL:CHEMBL560579 PubChem:43234 antibiotic_resistance ARO:3009182 propiconazole ARO:3009182 A fungicide that is used commercially for agriculture. It is also used in combination with permethrin in formulations of wood preserver. The compound is known as a DMI, or demethylation inhibiting fungicide, due to its binding with and inhibition of the 14-alpha demethylase enzyme from demethylating a precursor to ergosterol. Without this demethylation step, the ergosterols are not incorporated into the growing fungal cell membranes, and cellular growth is stopped. PMID:29507067 A fungicide used for the control of rice blast, it is not approved for use within the European Union. It has a role as a melanin synthesis inhibitor and an antifungal agrochemical. According to CHEBI, this compound is not a member of the azole group of antifungals, but is instead part of a group called the triazobenzothiazoles. CAS:41814-78-2 ChEBI:81783 ChEMBL:CHEMBL357021 PubChem:39040 antibiotic_resistance ARO:3009183 tricyclazole ARO:3009183 A fungicide used for the control of rice blast, it is not approved for use within the European Union. It has a role as a melanin synthesis inhibitor and an antifungal agrochemical. According to CHEBI, this compound is not a member of the azole group of antifungals, but is instead part of a group called the triazobenzothiazoles. PMID:24084639 Mebendazole has a role as an antinematodal drug, a tubulin modulator, and a fungal microtubule-destabilising agent. antibiotic_resistance ARO:3009184 mebendazole ARO:3009184 Mebendazole has a role as an antinematodal drug, a tubulin modulator, and a fungal microtubule-destabilising agent. PMID:35149760 Azoxystrobin (brand name Amistar, Syngenta) is widely used as a very broad spectrum fungicide in agriculture, particularly in wheat farming. It is an inhibitor of mitochondrial respiration by blocking electron transfer between cytochromes b and c1, and binds very tightly to the Qo site of Complex III of the mitochondrial electron transport chain, thereby ultimately preventing the generation of ATP. CAS:131860-33-8 ChEBI:40909 ChEMBL:CHEMBL230001 PubChem:3034285 antibiotic_resistance ARO:3009185 azoxystrobin ARO:3009185 Boscalid is a fungicide that is active against a broad range of fungal pathogens including Botrytis spp., Alternaria spp. and Sclerotinia spp. for use on a wide range of crops. It is functionally related to a nicotinic acid. Boscalid is unique in that it is a natural product derived from the fungi Ganoderma lucidum. CAS:188425-85-6 ChEBI:81822 ChEMBL:CHEMBL1076544 PubChem:213013 antibiotic_resistance ARO:3009186 boscalid ARO:3009186 Boscalid is a fungicide that is active against a broad range of fungal pathogens including Botrytis spp., Alternaria spp. and Sclerotinia spp. for use on a wide range of crops. It is functionally related to a nicotinic acid. Boscalid is unique in that it is a natural product derived from the fungi Ganoderma lucidum. PMID:21469935 PMID:24481672 PMID:30731698 PMID:35430062 Bromuconazole is a member of the class of oxolanes and is a foliar applied conazole fungicide for a range of crops. It is a dichlorobenzene, an organobromine compound, a member of oxolanes, a member of triazoles, a conazole fungicide and a triazole fungicide. CAS:116255-48-2 ChEBI:81900 ChEMBL:CHEMBL271579 PubChem:3444 antibiotic_resistance ARO:3009187 bromuconazole ARO:3009187 Cycloheximide appears as colorless crystals that can be used as a fungicide and as a anticancer drug. It is produced by the bacterium Streptomyces griseus and has a role as a bacterial metabolite, a protein synthesis inhibitor, a neuroprotective agent, an anticoronaviral agent and a ferroptosis inhibitor. It is a member of piperidones, a piperidine antibiotic, a fungicide, a dicarboximide, a secondary alcohol and a cyclic ketone. It is functionally related to a piperidine-2,6-dione. Cycloheximide can cause developmental toxicity. CAS:4630-75-5 ChEBI:27641 ChEMBL:CHEMBL123292 antibiotic_resistance ARO:3009188 cyclohexamide ARO:3009188 Cycloheximide appears as colorless crystals that can be used as a fungicide and as a anticancer drug. It is produced by the bacterium Streptomyces griseus and has a role as a bacterial metabolite, a protein synthesis inhibitor, a neuroprotective agent, an anticoronaviral agent and a ferroptosis inhibitor. It is a member of piperidones, a piperidine antibiotic, a fungicide, a dicarboximide, a secondary alcohol and a cyclic ketone. It is functionally related to a piperidine-2,6-dione. Cycloheximide can cause developmental toxicity. PMID:9271421 Cyproconazole is a fungicide that prevents wood decay from fungi in above-ground applications, but is not intended to protect trees in the ground. CAS:94361-06-5 ChEBI:83748 ChEMBL:CHEMBL2131954 PubChem:86132 antibiotic_resistance ARO:3009189 cyproconazole ARO:3009189 Cyproconazole is a fungicide that prevents wood decay from fungi in above-ground applications, but is not intended to protect trees in the ground. PMID:23589453 Difenoconazole is a broad spectrum fungicide with efficacy against some members of the Aschomycetes, Basidomycetes and Deuteromycetes families. It acts as a seed treatment, foliar spray and systemic fungicide. It is taken up through the surface of the infected plant and is translocated to all parts of the plant. It has a curative effect and a preventative effect. The mode of action of difenoconazole is that it is a sterol demethylation inhibitor which prevents the development of the fungus by inhibiting cell membrane ergosterol biosynthesis. CAS:119446-68-3 ChEBI:81760 ChEMBL:CHEMBL466426 PubChem:86173 antibiotic_resistance ARO:3009190 difenoconazole ARO:3009190 Difenoconazole is a broad spectrum fungicide with efficacy against some members of the Aschomycetes, Basidomycetes and Deuteromycetes families. It acts as a seed treatment, foliar spray and systemic fungicide. It is taken up through the surface of the infected plant and is translocated to all parts of the plant. It has a curative effect and a preventative effect. The mode of action of difenoconazole is that it is a sterol demethylation inhibitor which prevents the development of the fungus by inhibiting cell membrane ergosterol biosynthesis. PMID:26863444 Epoxiconazole was introduced in 1990 as a broad-spectrum fungicide with long-lasting activity. Even though epoxiconazole is produced and commercialized as a racemic compound, not surprisingly, a recent publication indicates that the optically pure (2S,3R) enantiomer of epoxiconazole is much more active against pathogenic fungi than its (2R,3S)-enantiomer, whereas the plant growth regulatory activity mainly rests in the (2R,3S)-enantiomer. CAS:133855-98-8 PubChem:107901 antibiotic_resistance ARO:3009191 epoxiconazole ARO:3009191 Epoxiconazole was introduced in 1990 as a broad-spectrum fungicide with long-lasting activity. Even though epoxiconazole is produced and commercialized as a racemic compound, not surprisingly, a recent publication indicates that the optically pure (2S,3R) enantiomer of epoxiconazole is much more active against pathogenic fungi than its (2R,3S)-enantiomer, whereas the plant growth regulatory activity mainly rests in the (2R,3S)-enantiomer. PMID:29507067 OXY-1-7 is a OXY family class A extended-spectrum beta-lactamase identified from Klebsiella oxytoca. OXY-1-7 antibiotic_resistance ARO:3009192 OXY-1-7 ARO:3009192 OXY-1-7 Ontological connectedness between entities and/or interactions representing their relatedness or influence (paraphrased from Systems Biology Ontology) specific to CARD's Antibiotic Resistance Ontology. antibiotic_resistance ARO:3009193 ARO relationship type ARO:3009193 A respiratory system disease which involves the lower respiratory tract. antibiotic_resistance DOID:0050161 lower respiratory tract disease DOID:0050161 A lung disease characterized by inadequate gas exchange by the respiratory system. antibiotic_resistance DOID:11162 respiratory failure DOID:11162 A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia. antibiotic_resistance DOID:11394 adult respiratory distress sydrome DOID:11394 A respiratory failure that is characterized by deficiency of the surfactant coating the inner surface of the lungs, by failure of the lungs to expand and contract properly during breathing with resulting collapse, and by the accumulation of a protein-containing film lining the alveoli and their ducts. antibiotic_resistance DOID:12716 newborn respiratory distress syndrome DOID:12716 A cystitis characterized by a sudden onset or severe symptoms. antibiotic_resistance DOID:13148 acute cystitis DOID:13148 A disease of anatomical entity that located_in the respiratory system which extends from the nasal sinuses to the diaphragm. antibiotic_resistance DOID:1579 respiratory system disease DOID:1579 An integumentary system disease that is located in the skin. antibiotic_resistance DOID:37 skin disease DOID:37 A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide. antibiotic_resistance DOID:850 lung disease DOID:850 A circumscribed area of pus or necrotic debris in the skin. antibiotic_resistance HP:0031292 cutaneous abscess HP:0031292 Gram staining is a method for staining and identifying bacteria. It is based on the differential retention of a crystal violet-iodine complex within the cell membrane. The cell wall of gram-positive cells have a thick peptidoglycan layer that retains crystal violet after an alcohol wash (staining black-blue or purple by a counterstain). The cell wall of gram-negative cells have a thinner peptidoglycan layer that does not retain crystal violet after an alcohol wash (staining red after counterstain). Some cells have variable staining in culture (e.g. Bacillus, Clostridium) while others have indeterminate staining due to unique aspects of their cell membrane or wall (e.g. Mycobacterium, Mycoplasma). antibiotic_resistance NCIT:23014 gram stain NCIT:23014 Gram staining is a method for staining and identifying bacteria. It is based on the differential retention of a crystal violet-iodine complex within the cell membrane. The cell wall of gram-positive cells have a thick peptidoglycan layer that retains crystal violet after an alcohol wash (staining black-blue or purple by a counterstain). The cell wall of gram-negative cells have a thinner peptidoglycan layer that does not retain crystal violet after an alcohol wash (staining red after counterstain). Some cells have variable staining in culture (e.g. Bacillus, Clostridium) while others have indeterminate staining due to unique aspects of their cell membrane or wall (e.g. Mycobacterium, Mycoplasma). PMID:19885931 A method to determine whether microbial growth is affected by an antimicrobial compound. antibiotic_resistance NCIT:85540 microbial susceptibility test NCIT:85540 A method to determine microbial susceptibility to antibiotics wherein bacteria are inoculated onto agar plates and the antimicrobial agent diffused onto the agar plate from a filter paper disk. An approximate, but not exact, MIC is determined by the diameter of growth inhibition zones. This method has been found to have good correlation between in-vivo data and in-vitro data. Kirby-Bauer disk assay antibiotic_resistance NCIT:85595 disk-diffusion method NCIT:85595 A method to determine microbial susceptibility to antibiotics wherein bacteria are inoculated onto agar plates and the antimicrobial agent diffused onto the agar plate from a filter paper disk. An approximate, but not exact, MIC is determined by the diameter of growth inhibition zones. This method has been found to have good correlation between in-vivo data and in-vitro data. PMID:29403965 A method to determine microbial susceptibility to antibiotics in which a plastic strip impregnated with the antibiotic of interest is placed on an agar plate that has been inoculated with bacteria. The antibiotic diffuses from the strip producing a concentration gradient of drug on the agar. The point at which the elliptical shaped area of growth inhibition meets the strip is the minimum inhibitory concentration of the drug of interest. antibiotic_resistance NCIT:85596 antimicrobial gradient method (E-test) NCIT:85596 A method to determine microbial susceptibility to antibiotics in which a plastic strip impregnated with the antibiotic of interest is placed on an agar plate that has been inoculated with bacteria. The antibiotic diffuses from the strip producing a concentration gradient of drug on the agar. The point at which the elliptical shaped area of growth inhibition meets the strip is the minimum inhibitory concentration of the drug of interest. PMID:29403965 A method to determine the minimum inhibitory concentration (MIC) of antibiotics in which growth media is pipetted into a multi-well plate. Each well contains a known concentration of drug which is inoculated with a known quantity of bacteria. The plate is incubated for a specified period of time and each well is assessed for bacterial cell growth. The drug concentration in the first well showing no growth is known as the MIC for that antibiotic. Minimum 2 mL total broth dilution volume. antibiotic_resistance NCIT:85701 macro broth dilution method NCIT:85701 A method to determine the minimum inhibitory concentration (MIC) of antibiotics in which growth media is pipetted into a multi-well plate. Each well contains a known concentration of drug which is inoculated with a known quantity of bacteria. The plate is incubated for a specified period of time and each well is assessed for bacterial cell growth. The drug concentration in the first well showing no growth is known as the MIC for that antibiotic. Minimum 2 mL total broth dilution volume. PMID:29403965 Skin lesion is a skin and integumentary tissue symptom characterized as an abnormal change in structure of the skin that is especially circumscribed and well defined due to injury or disease. antibiotic_resistance SYMP:0000092 skin lesion SYMP:0000092 The outer epithelial layer of the skin that is superficial to the dermis. antibiotic_resistance UBERON:0001003 skin epidermis UBERON:0001003 A female organ involved in reproduction. antibiotic_resistance UBERON:0003134 female reproductive organ UBERON:0003134 A male organ involved in reproduction. antibiotic_resistance UBERON:0003135 male reproductive organ UBERON:0003135 A relationship ontology term in which the subject (usually an enzyme, protein or other gene product) confers or contributes to clinically relevant resistance to a specific antibiotic drug. An entity is resistant to a chemical compound if and only if x is a pathogen and y is an antibiotic, and the fitness of that pathogen is not decreased when exposed to that antibiotic. ARO:2000000 antibiotic_resistance ARO:2000000 confers_resistance_to_antibiotic confers_resistance_to_antibiotic confers_resistance_to_antibiotic confers_resistance_to_antibiotic A relationship ontology term in which the subject (e.g., a gene family) confers or contributes to antibiotic resistance to some or all of the object (e.g. a drug class). It is a qualitative measure of antibiotic resistance, based on an experiment illustrating elevated MIC even outside of a clinical setting. A family of AMR genes confers resistance to a class of antibiotics if and only if all instances of that family confer resistance to some instances of that class in an organism. ARO:2000001 antibiotic_resistance ARO:2000001 confers_resistance_to_drug_class confers_resistance_to_drug_class confers_resistance_to_drug_class confers_resistance_to_drug_class A component of tripartite efflux systems that resides in the inner membrane of Gram-negative bacteria that actively transports substrates out of the cell. ARO:2000002 antibiotic_resistance ARO:2000002 inner_membrane_protein_of inner_membrane_protein_of inner_membrane_protein_of inner_membrane_protein_of A component of tripartite efflux systems that resides in the outer membrane of Gram-negative bacteria. The outer membrane protein forms a channel or pore that spans the outer membrane, enabling the export of substrates directly into the extracellular environment. ARO:2000003 antibiotic_resistance ARO:2000003 outer_membrane_protein_of outer_membrane_protein_of outer_membrane_protein_of ARO:2000003 A bridging component of tripartite efflux systems in Gram-negative bacteria, located in the periplasmic space. The periplasmiic adaptor protein links the inner membrane transporter and the outer membrane protein, stabilizing the efflux complex and facilitating substrate transport. ARO:2000004 antibiotic_resistance ARO:2000004 periplasmic_adaptor_protein_of periplasmic_adaptor_protein_of periplasmic_adaptor_protein_of periplasmic_adaptor_protein_of A relationship ontology term in which the subject is targeted by the object (usually a class of antibiotics). ARO:2000007 antibiotic_resistance ARO:2000007 targeted_by targeted_by targeted_by ARO:2000007 A relationship ontology term in which the subject is targeted by a specific antibiotic. ARO:2000008 antibiotic_resistance ARO:2000008 targeted_by_antibiotic targeted_by_antibiotic targeted_by_antibiotic ARO:2000008 BFO:0000051 antibiotic_resistance has_part has_part has_part RO:0000056 antibiotic_resistance participates_in participates_in participates_in RO:0001000 antibiotic_resistance derives_from derives_from derives_from RO:0002211 antibiotic_resistance regulates regulates regulates RO:0002212 antibiotic_resistance negatively_regulates negatively_regulates negatively_regulates RO:0002213 antibiotic_resistance positively_regulates positively_regulates positively_regulates RO:0002312 antibiotic_resistance evolutionary_variant_of evolutionary_variant_of evolutionary_variant_of RO:0002407 antibiotic_resistance indirectly_positively_regulates indirectly_positively_regulates indirectly_positively_regulates RO:0002409 antibiotic_resistance indirectly_negatively_regulates indirectly_negatively_regulates indirectly_negatively_regulates RO:0012006 antibiotic_resistance is_small_molecule_inhibitor_of is_small_molecule_inhibitor_of is_small_molecule_inhibitor_of cv2obo 29:05:2025 10:16 antibiotic_resistance 1.2 CARD