Aug 03, 2013 Contributors are those that engage in discussions in the context of SIO (in alphabetical order): christopher baker joachim baran jerven bolleman alison callahan leonid chepelev kevin cohen melanie courtot geraint duck luke mccarthy jim mccusker jose miguel cruz-toledo robert hoehndorf simon jupp jin-dong kim dana klassen james malone chris mungall david osumi-sutherland nuria queralt alexandre riazanov matthias samwald robert stevens mark wilkinson natalia villanueva-rosales Magdalena J Przydzial, Barun Bhhatarai, Amar Koleti, Stephan Schurer Michel Dumontier The semanticscience integrated ontology (SIO) provides a simple, integrated ontology (types, relations) for objects, processes and their attributes. This project provides foundational support for the Bio2RDF (http://bio2rdf.org) and SADI (http://sadiframework.org) projects. website: http://semanticscience.org email: sio-ontology@googlegroups.com mailing list: http://groups.google.com/group/sio-ontology use,share,modify,commercial; by attribution [http://creativecommons.org/licenses/by/3.0/]. G Protein-Coupled Receptor (GPCR) BioAssays ontology Semanticscience Integrated Ontology (SIO) Contact: Stephan Schurer: sschurer at med.miami.edu or visit bioassayontology.org general class inclusion axioms: 'is part of' some 'physical entity' subClassOf 'is located in' some 'physical entity' role chains: 'has capability' o 'is realized in' -> 'is participant in' 0.9.14 1.1 definition imported from Previous_and_unofficial_names symbol has_alternative_id has_broad_synonym database_cross_reference has_exact_synonym has_narrow_synonym has_obo_namespace has_related_synonym in_subset A is related to B iff there is some relation between A and B. 'is related to' is the top level relation in SIO is related to has attribute is a relation that associates a entity with an attribute where an attribute is an intrinsic characteristic such as a quality, capability, disposition, function, or is an externally derived attribute determined from some measurement (e.g. a quantity, position, label/identifier) either directly or indirectly through generalization of entities of the same type. has attribute is attribute of is a relation that associates an attribute with an entity where an attribute is an intrinsic characteristic such as a quality, capability, disposition, function, or is an externally derived attribute determined from some measurement (e.g. a quantity, position, label/identifier) either directly or indirectly through generalization of entities of the same type. is attribute of A is located in B iff the spatial region occupied by A is part of the spatial region occupied by B. [T][R] OBO_REL:located_in A parasite in the interior of a person's intestine is located in their intestinal lumen. is located in is participant in is a relation that describes the participation of the subject in the (processual) object. a car is a participant in a car race; glucose is a participant in glycolysis is participant in is part of is a transitive, reflexive and anti-symmetric mereological relation between a whole and itself or a part and its whole. OBO_REL:part_of is part of is member of is a mereological relation between a item and a collection. is member of A is spatiotemporally related to B iff A is in the spatial or temporal vicinity of B is spatiotemporally related to An abstract concept representing a measurement or parameter quantifying or qualifying a perturbation. An endpoint consists of a series of data points, one for each perturbing agent employed by the assay. Another way to think of an endpoint is as a column in a spreadsheet with "compound ID" on the vertical axis. PubChem specifies two generic endpoints, "Outcome" and "Score", for every assay. has_endpoint has_target has_ligand_type has_function is_receptor_type_of is_ligand_type_of has_receptor_type binds_to The order of amino acid residues that make up a unique protein. A primary structure of a protein. has protein sequence A depiction of the receptor confirmation. has receptor structure A three dimensional, experimentally determined arrangement of atoms in a molecule (here, macromolecule). has crystal structure Also known as comparative model of protein, homology model refers to constructing an atomic-resolution plan of the "target" protein from its amino acid sequence and an experimental three-dimensional structure of a related homologous protein (the "template"). Homology modeling relies on the identification of one or more known protein structures likely to resemble the structure of the query sequence, and on the production of an alignment that maps residues in the query sequence to residues in the template sequence has homology model The most authoritative collection of disclosed chemical substance information, containing more than 63 million organic and inorganic substances and 63 million sequences. Each CAS Registry Number (often referred to as a CAS Number): Is a unique numeric identifier Designates only one substance, Has no chemical significance, Is a link to a wealth of information about a specific chemical substance. has CAS registry number It is the information about the atoms that constitute a particular chemical compound. The chemical formula identifies each constituent element by its chemical symbol and indicates the number of atoms of each element found in each discrete molecule of that compound. has chemical formula International Chemical Identifier has InChI A systematic chemical name generated according to the International Union of Pure and Applied Chemistry (IUPAC) rules. has IUPAC name The weight of a molecule is the sum of the weights of the atoms of which it is made. has molecular weight has ID The PubChem Substance accession identifier (SID). has PubChem SID The simplified molecular input line entry specification or SMILES is a specification in form of a line notation for describing the structure of chemical molecules using short ASCII strings. SMILES strings can be imported by most molecule editors for conversion back into two-dimensional drawings or three-dimensional models of the molecules. has SMILES It is the unique identification number of the gene that was a target in the bioassay. Gene ID is obtained by referring to other databases such as the NCBI Entrez. has Gene symbol Indicates the species of the receptor has species It is the unique identification number of the protein that was perturbed in the bioassay, which is obtained by referring to the UniProt database. has UniProt ID It is the unique identification number pertaining to the taxonomy of the organism tested in the bioassay. It is obtained by referring to the NCBI taxonomy database. has NCBI taxonomy ID The regulated release of serotonin by a cell or group of cells. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells. 5-HT secretion 5-hydroxytryptamine secretion biological_process serotonin release GO:0001820 serotonin secretion GO:0001820 GO:0002031 The process that results in the uptake of a G-protein coupled receptor into an endocytic vesicle. biological_process GO:0002031 G-protein coupled receptor internalization GO:0002031 GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. Wikipedia:Enzyme enzyme activity molecular_function GO:0003824 catalytic activity GO:0003824 Catalysis of the reaction: GTP + H2O = GDP + phosphate. GTPases (singular GTPase) are a large family of hydrolase enzymes that can bind and hydrolyze guanosine triphosphate (GTP). The GTP binding and hydrolysis takes place in the highly conserved G domain common to all GTPases. hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement RHEA:19672 Reactome:REACT_100432 Reactome:REACT_100708 Reactome:REACT_101121 Reactome:REACT_101520 Reactome:REACT_101563 Reactome:REACT_101678 Reactome:REACT_102040 Reactome:REACT_102208 Reactome:REACT_102307 Reactome:REACT_102371 Reactome:REACT_102510 Reactome:REACT_102532 Reactome:REACT_103518 Reactome:REACT_104081 Reactome:REACT_104477 Reactome:REACT_104739 Reactome:REACT_105323 Reactome:REACT_105697 Reactome:REACT_105708 Reactome:REACT_105854 Reactome:REACT_106121 Reactome:REACT_106217 Reactome:REACT_106301 Reactome:REACT_106528 Reactome:REACT_107176 Reactome:REACT_107306 Reactome:REACT_107730 Reactome:REACT_107820 Reactome:REACT_108363 Reactome:REACT_108653 Reactome:REACT_108825 Reactome:REACT_108837 Reactome:REACT_109360 Reactome:REACT_109897 Reactome:REACT_110131 Reactome:REACT_110443 Reactome:REACT_110557 Reactome:REACT_110859 Reactome:REACT_110879 Reactome:REACT_110931 Reactome:REACT_111994 Reactome:REACT_112104 Reactome:REACT_112254 Reactome:REACT_112389 Reactome:REACT_112587 Reactome:REACT_112651 Reactome:REACT_112671 Reactome:REACT_113058 Reactome:REACT_113209 Reactome:REACT_113727 Reactome:REACT_113832 Reactome:REACT_113952 Reactome:REACT_113954 Reactome:REACT_114148 Reactome:REACT_114153 Reactome:REACT_114188 Reactome:REACT_114210 Reactome:REACT_114331 Reactome:REACT_114379 Reactome:REACT_114384 Reactome:REACT_114532 Reactome:REACT_114620 Reactome:REACT_114824 Reactome:REACT_115229 Reactome:REACT_115324 Reactome:REACT_12396 Reactome:REACT_12397 Reactome:REACT_12456 Reactome:REACT_12612 Reactome:REACT_15316 Reactome:REACT_15335 Reactome:REACT_15449 Reactome:REACT_15495 Reactome:REACT_19123 Reactome:REACT_19178 Reactome:REACT_19186 Reactome:REACT_19194 Reactome:REACT_19219 Reactome:REACT_19255 Reactome:REACT_19317 Reactome:REACT_22359 Reactome:REACT_28065 Reactome:REACT_28251 Reactome:REACT_28269 Reactome:REACT_29162 Reactome:REACT_30456 Reactome:REACT_30463 Reactome:REACT_30562 Reactome:REACT_30687 Reactome:REACT_30707 Reactome:REACT_30942 Reactome:REACT_31226 Reactome:REACT_31474 Reactome:REACT_31530 Reactome:REACT_31599 Reactome:REACT_31709 Reactome:REACT_31727 Reactome:REACT_31850 Reactome:REACT_32006 Reactome:REACT_32028 Reactome:REACT_32914 Reactome:REACT_33948 Reactome:REACT_34113 Reactome:REACT_34480 Reactome:REACT_34592 Reactome:REACT_34735 Reactome:REACT_348 Reactome:REACT_36834 Reactome:REACT_37542 Reactome:REACT_552 Reactome:REACT_6171 Reactome:REACT_712 Reactome:REACT_75799 Reactome:REACT_77032 Reactome:REACT_77303 Reactome:REACT_78069 Reactome:REACT_78231 Reactome:REACT_78653 Reactome:REACT_78945 Reactome:REACT_79558 Reactome:REACT_79620 Reactome:REACT_80275 Reactome:REACT_80612 Reactome:REACT_81304 Reactome:REACT_81448 Reactome:REACT_81580 Reactome:REACT_81664 Reactome:REACT_81879 Reactome:REACT_82203 Reactome:REACT_82263 Reactome:REACT_82457 Reactome:REACT_82603 Reactome:REACT_82704 Reactome:REACT_83308 Reactome:REACT_83403 Reactome:REACT_83440 Reactome:REACT_83730 Reactome:REACT_84204 Reactome:REACT_84553 Reactome:REACT_84696 Reactome:REACT_84712 Reactome:REACT_84735 Reactome:REACT_85008 Reactome:REACT_85418 Reactome:REACT_85769 Reactome:REACT_85972 Reactome:REACT_86227 Reactome:REACT_86358 Reactome:REACT_86400 Reactome:REACT_86630 Reactome:REACT_86760 Reactome:REACT_86972 Reactome:REACT_87409 Reactome:REACT_87506 Reactome:REACT_87558 Reactome:REACT_87653 Reactome:REACT_87661 Reactome:REACT_88045 Reactome:REACT_88357 Reactome:REACT_89231 Reactome:REACT_89292 Reactome:REACT_89416 Reactome:REACT_89668 Reactome:REACT_89763 Reactome:REACT_90050 Reactome:REACT_90064 Reactome:REACT_90517 Reactome:REACT_90703 Reactome:REACT_91199 Reactome:REACT_91588 Reactome:REACT_92176 Reactome:REACT_92197 Reactome:REACT_92198 Reactome:REACT_92450 Reactome:REACT_93249 Reactome:REACT_93305 Reactome:REACT_93641 Reactome:REACT_93742 Reactome:REACT_93772 Reactome:REACT_94019 Reactome:REACT_94095 Reactome:REACT_94305 Reactome:REACT_94760 Reactome:REACT_95238 Reactome:REACT_95563 Reactome:REACT_96019 Reactome:REACT_96132 Reactome:REACT_96223 Reactome:REACT_96612 Reactome:REACT_96881 Reactome:REACT_97284 Reactome:REACT_97405 Reactome:REACT_97595 Reactome:REACT_97794 Reactome:REACT_98431 Reactome:REACT_98556 Reactome:REACT_98837 Reactome:REACT_98859 Reactome:REACT_99479 Reactome:REACT_99533 Reactome:REACT_99616 ARF small monomeric GTPase activity RHEB small monomeric GTPase activity Rab small monomeric GTPase activity Ran small monomeric GTPase activity Ras small monomeric GTPase activity Rho small monomeric GTPase activity Sar small monomeric GTPase activity dynamin GTPase activity heterotrimeric G-protein GTPase activity protein-synthesizing GTPase activity protein-synthesizing GTPase activity, elongation protein-synthesizing GTPase activity, initiation protein-synthesizing GTPase activity, termination signal-recognition-particle GTPase activity small monomeric GTPase activity tubulin GTPase activity molecular_function heterotrimeric G-protein GTPase, alpha-subunit heterotrimeric G-protein GTPase, beta-subunit heterotrimeric G-protein GTPase, gamma-subunit GO:0003924 GTPase activity GO:0003924 GO:0004709 Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. GO:0004710 EC:2.7.11.- EC:2.7.11.25 MetaCyc:2.7.11.25-RXN Reactome:REACT_105756 Reactome:REACT_107518 Reactome:REACT_108303 Reactome:REACT_114785 Reactome:REACT_19141 Reactome:REACT_22190 Reactome:REACT_22271 Reactome:REACT_22411 Reactome:REACT_81738 Reactome:REACT_85351 Reactome:REACT_85999 ATP:protein phosphotransferase (MAPKKKK-activated) activity MAPK/ERK kinase kinase activity MAPKKK activity MEK kinase activity MEKK activity mitogen-activated protein kinase kinase kinase activity MLK-like mitogen-activated protein triple kinase activity molecular_function MAP3K MEKK MEKK1 MEKK2 MEKK3 MLTK MLTKa MLTKb Mil/Raf REKS STK28 cMos cRaf GO:0004709 MAP kinase kinase kinase activity GO:0004709 GO:0005102 Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. Wikipedia:Ligand_(biochemistry) receptor ligand molecular_function receptor-associated protein activity GO:0005102 receptor binding GO:0005102 GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. GO:0023033 Reactome:REACT_100624 Reactome:REACT_102354 Reactome:REACT_112130 Reactome:REACT_112549 Reactome:REACT_113151 Reactome:REACT_113601 Reactome:REACT_113964 Reactome:REACT_114657 Reactome:REACT_114690 Reactome:REACT_114820 Reactome:REACT_114910 Reactome:REACT_115037 Reactome:REACT_115147 Reactome:REACT_12478 Reactome:REACT_31232 Reactome:REACT_78535 Reactome:REACT_89740 Reactome:REACT_93680 Reactome:REACT_98872 Wikipedia:Signal_transduction signaling cascade signalling cascade biological_process signaling pathway signalling pathway GO:0007165 Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not. signal transduction GO:0007165 GO:0007259 Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins. biological_process GO:0007259 JAK-STAT cascade GO:0007259 The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin. Reactome:REACT_100716 Reactome:REACT_102134 Reactome:REACT_102586 Reactome:REACT_102743 Reactome:REACT_105010 Reactome:REACT_105885 Reactome:REACT_110862 Reactome:REACT_11184 Reactome:REACT_113329 Reactome:REACT_115061 Reactome:REACT_13723 Reactome:REACT_29477 Reactome:REACT_29495 Reactome:REACT_29928 Reactome:REACT_77375 Reactome:REACT_85993 Reactome:REACT_91316 Reactome:REACT_95406 Reactome:REACT_99398 neurotransmitter release biological_process GO:0007269 neurotransmitter secretion GO:0007269 GO:0010737 A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound. PKA signaling cascade protein kinase A signalling cascade biological_process GO:0010737 protein kinase A signaling cascade GO:0010737 The regulated release of dopamine by a cell or group of cells. Dopamine is a catecholamine and a precursor of adrenaline and noradrenaline. It acts as a neurotransmitter in the central nervous system but it is also produced peripherally and acts as a hormone. biological_process GO:0014046 dopamine secretion GO:0014046 The controlled release of glutamate by a cell or group of cells. The glutamate is the most abundant excitatory neurotransmitter in the nervous system. Reactome:REACT_109562 Reactome:REACT_110427 Reactome:REACT_110783 Reactome:REACT_112750 Reactome:REACT_12591 Reactome:REACT_28102 Reactome:REACT_28436 Reactome:REACT_29157 Reactome:REACT_30788 Reactome:REACT_32657 Reactome:REACT_78627 Reactome:REACT_79842 Reactome:REACT_89854 Reactome:REACT_94050 Reactome:REACT_94627 Reactome:REACT_95715 biological_process GO:0014047 glutamate secretion GO:0014047 The regulated release of gamma-aminobutyric acid by a cell or group of cells. The gamma-aminobutyric acid is the principal inhibitory neurotransmitter in the brain but is also found in several extraneural tissues. GABA secretion biological_process GO:0014051 gamma-aminobutyric acid secretion GO:0014051 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. EC:3 Reactome:REACT_110436 Reactome:REACT_111159 Reactome:REACT_15331 Reactome:REACT_83734 Reactome:REACT_84047 Reactome:REACT_87959 Reactome:REACT_88159 Reactome:REACT_90118 Reactome:REACT_91045 Reactome:REACT_98572 molecular_function GO:0016787 hydrolase activity GO:0016787 Any intracellular signal transduction in which the signal is passed on within the cell via a second messenger; a small molecule or ion that can be quickly generated or released from intracellular stores, and can diffuse within the cell. Second-messenger signaling includes production or release of the second messenger, and effectors downstream of the second messenger that further transmit the signal within the cell. second messenger mediated signaling second messenger mediated signalling second messenger-mediated signaling second messenger-mediated signalling second-messenger-mediated signalling biological_process GO:0019932 second-messenger-mediated signaling GO:0019932 GO:0023061 The process in which a signal is secreted or discharged into the extracellular medium from a cellular source. biological_process GO:0023061 signal release GO:0023061 GO:0043491 A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B, which occurs as a result of a single trigger reaction or compound. AKT signaling cascade AKT signalling cascade PKB signaling cascade PKB signalling cascade protein kinase B signalling cascade biological_process GO:0043491 protein kinase B signaling cascade GO:0043491 The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells. biological_process GO:0046879 hormone secretion GO:0046879 The controlled release of a Wnt protein from a cell or group of cells. biological_process GO:0061355 Wnt protein secretion GO:0061355 GO:0070528 A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. PKC signaling cascade protein kinase C signalling cascade biological_process GO:0070528 protein kinase C signaling cascade GO:0070528 BAO_0000015 An experiment carried out for the purpose of testing the effect of a perturbing agent in a biological system, measuring one or multiple effect(s) of the agent facilitated by an assay design / assay technology to translate the perturbation into a detectable signal to arrive at one or multiple endpoint(s) that quantify or qualify the extent of the perturbation. Bioassay is described by multiple bioassay components: format, perturbagen, meta target, technology, detection method, and endpoint. Bioassay includes one or multiple measure groups to describe multiparametric (or multiplexed) assays (assays that measure more than one effect of the perturbagen on the system that is screened). placeholder Bioassay BAO_0000023 Low molecular weight, non-peptidic, non-polymeric compounds produced via either total synthesis or semi-synthetic processes. small organic molecule Synthetic small molecule BAO_0000036 Indicates that the ligand is radioactive. Radioactivity is the spontaneous disintegration of atomic nuclei. Radiolabeled BAO_0000074 Mode of action (ligand efficacy) refers to the ability of the ligand to produce a biological response upon binding to the target receptor and the quantitative magnitude of this response. This response may be as an agonist, antagonist, or inverse agonist, depending on the physiological response produced. Mode of action BAO_0000171 Lipid is any group of organic compounds, including the fats, oils, waxes, sterols, and triglycerides, that are insoluble in water but soluble in nonpolar organic solvents, are oily to the touch, and together with carbohydrates and proteins constitute the principal structural material of living cells. prostaglandins, prostanoids, platelet-activating factor, and leukotrienes Lipid BAO_0000280 Ion channels are pore-forming proteins that help establish and control the small voltage gradient across the plasma membrane of cells (see cell potential) by allowing the flow of ions down their electrochemical gradient. Ion channel BAO_0000284 GPCR Integral plasma membrane proteins that transduce signals from extracellular ligands to signals in intracellular heterotrimeric GTP binding proteins (G proteins). By coupling to many downstream effectors, the G proteins initiate pleiotropic changes in many targets. Thus, the extracellular signal is typically amplified to produce robust, varied, and cell-specific responses. G protein-coupled receptor BAO_0000325 Peptide is a short polymer of amino acid monomers linked by peptide bonds. Peptide BAO_0002088 Ligands that activate ion channels by binding directly to them, including ligands that cause a change in the voltage dependence of channel gating that favors activation. Activator BAO_0003052 Location of protein within a cell (i.e., integral to plasma membrane). placeholder Cellular component BAO_0003074 Indicates that the ligand is that is bound to the receptor in an unperturbed in vivo setting in the species of the receptor under test. Endogenous BAO_0200022 An alpha-1 adrenergic receptor that is a translation product of the ADRA1A gene or a 1:1 ortholog thereof.[PRO:WCB] ADRA1A ADRA1A PRO:000001183 Alpha-1A adrenergic receptor BAO_0200023 An alpha-1 adrenergic receptor that is a translation product of the ADRA1B gene or a 1:1 ortholog thereof. [PRO:WCB] ADRA1B ADRA1B PRO:000001184 Alpha-1B adrenergic receptor BAO_0200024 An alpha-1 adrenergic receptor that is a translation product of the ADRA1D gene or a 1:1 ortholog thereof. [PRO:WCB] ADRA1D ADRA1D PRO:000001185 Alpha-1D adrenergic receptor BAO_0200025 An alpha-2 adrenergic receptor that is a translation product of the ADRA2A gene or a 1:1 ortholog thereof. [PRO:WCB] ADRA2A ADRA2A PRO:000001186 Alpha-2A adrenergic receptor BAO_0200026 An alpha-2 adrenergic receptor that is a translation product of the ADRA2B gene or a 1:1 ortholog thereof. [PRO:WCB] ADRA2B ADRA2B PRO:000001187 Alpha-2B adrenergic receptor BAO_0200027 An alpha-2 adrenergic receptor that is a translation product of the ADRA2C gene or a 1:1 ortholog thereof. [PRO:WCB] ADRA2C ADRA2C PRO:000001188 Alpha-2C adrenergic receptor BAO_0200028 A beta adrenergic receptor that is a translation product of the ADRB1 gene or a 1:1 ortholog thereof. [PRO:WCB] ADRB1 ADRB1 PRO:000001192 Beta-1 adrenergic receptor BAO_0200029 A beta adrenergic receptor that is a translation product of the ADRB2 gene or a 1:1 ortholog thereof. [PRO:WCB] ADRB2 ADRB2 PRO:000001193 Beta-2 adrenergic receptor BAO_0200030 A beta adrenergic receptor that is a translation product of the ADRB3 gene or a 1:1 ortholog thereof. [PRO:WCB] ADRB3 ADRB3 PRO:000001194 Beta-3 adrenergic receptor BAO_0200079 Aminergic receptor BAO_0200124 A nicotinic acid receptor that is a translation product of the GPR81 gene or a 1:1 ortholog thereof. It has low affinity for nicotinic acid. [PRO:WCB] HCAR1 GPR104 GPR81 PRO:000001649 Hydroxycarboxylic acid receptor 1 BAO_0200125 nicotinic acid receptor 1 A nicotinic acid receptor that is a translation product of the GPR109A gene or a 1:1 ortholog thereof. The preferred ligand is nicotinic acid. [PRO:WCB] HCAR2 GPR109A PRO:000001629 Hydroxycarboxylic acid receptor 2 BAO_0200126 nicotinic acid receptor 2 A nicotinic acid receptor that is a translation product of the GPR109B gene or a 1:1 ortholog thereof. This gene is a recent duplication in primates of the GPR109A gene and has no rodent counterpart. This receptor has low affinity for nicotinic acid. [PRO:WCB] HCAR3 GPR109B PRO:000001630 Hydroxycarboxylic acid receptor 3 BAO_0200127 An opioid receptor that is a translation product of the OPRD1 gene or a 1:1 ortholog thereof. The preferred ligands are enkephalins. [PRO:WCB, Wikipedia:delta_Opioid_receptor] KOR OPRK OPRD1 PRO:000001579 Delta-type opioid receptor BAO_0200128 An opioid receptor that is a translation product of the OPRK1 gene or a 1:1 ortholog thereof. The preferred ligand is dynorphin. [PRO:WCB, Wikipedia:kappa_Opioid_receptor] OPRD OPRK1 PRO:000001590 Kappa-type opioid receptor BAO_0200174 A chemokine receptor CXCR7 that is a translation product of the CXCR7 gene or a 1:1 ortholog thereof. The preferred ligand may be CXCL12. No signaling pathway has been identified. [PMID:16107333, PRO:WCB] CMKOR1 CXCR7 GPR159 RDC1 CXCR7 PRO:000001211 C-X-C chemokine receptor type 7 BAO_0200187 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR21 or GPR52 gene. [PRO:WCB] GPR21 GPR21 PRO:000001522 G protein-coupled receptor 21 BAO_0200211 G protein-coupled receptor 79, pseudogene. GPR79 GPR79 G protein-coupled receptor 79 BAO_0200256 The protein encoded by this gene belongs to the family of G protein-coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. ARWH1 LAH3 LPAR6 MGC120358 P2RY5 P2Y5 P2RY5 Lysophosphatidic acid receptor 6 BAO_0200262 A trace amine-associated receptor 1-4 that is a translation product of the TAAR4 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. The preferred ligands of the rat protein are beta-phenylethylamine and tryptamine. The corresponding human gene, TAAR4P, is non-functional. [PMID:11459929, PRO:WCB] TAAR4 TAAR4 PRO:000001714 Trace amine-associated receptor 4 BAO_0200289 GABAB-related G protein-coupled receptor; probable G protein-coupled receptor 156 GABABL MGC142261 PGR28 GPR156 G protein-coupled receptor 156 BAO_0200291 The serotonin receptors, also known as 5-hydroxytryptamine receptors or 5-HT receptors, are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. They mediate both excitatory and inhibitory neurotransmission. The serotonin receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand. The serotonin receptors modulate the release of many neurotransmitters, including glutamate, GABA, dopamine, epinephrine / norepinephrine, and acetylcholine, as well as many hormones, including oxytocin, prolactin, vasopressin, cortisol, corticotropin, and substance P, among others. The serotonin receptors influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation. The serotonin receptors are the target of a variety of pharmaceutical and illicit drugs, including many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens. 5-Hydroxytryptamine receptor BAO_0200292 Muscarinic receptors, or mAChRs, are acetylcholine receptors that form G protein-coupled in the plasma membranes of certain neurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibers in the parasympathetic nervous system. Acetylcholine receptor BAO_0200293 The adenosine receptors (or P1 receptors) are a class of purinergic receptors, G protein-coupled receptors with adenosine as endogenous ligand. Adenosine receptor BAO_0200294 The adrenergic receptors (or adrenoceptors) are a class of metabotropic G protein-coupled receptors that are targets of the catecholamines, especially noradrenaline (norepinephrine) and adrenaline (epinephrine). Although dopamine is a catecholamine, its receptors are in a different category. Many cells possess these receptors, and the binding of an agonist will generally cause a sympathetic (or sympathomimetic) response (e.g. the fight-or-flight response). For instance, the heart rate will increase and the pupils will dilate, energy will be mobilized, and blood flow diverted from other non-essential organs to skeletal muscle. Adrenoceptor BAO_0200295 The anaphylatoxin receptors are a group of G protein-coupled receptors which bind anaphylatoxins. Anaphylatoxins, or anaphylotoxins, are fragments ( C3a, C4a and C5a) that are produced as part of the activation of the complement system. Complement components C3, C4 and C5 are large glycoproteins that have important functions in the immune response and host defense Anaphylatoxin receptor BAO_0200296 The angiotensin receptors are a class of G protein-coupled receptors with angiotensin II as their ligands. They are important in the renin-angiotensin system: they are responsible for the signal transduction of the vasoconstricting stimulus of the main effector hormone, angiotensin II. Angiotensin receptor BAO_0200297 A class 1 GPCR that binds apelin. Apelin is widely expressed in various organs such as the heart, lung, kidney, liver, adipose tissue, gastrointestinal tract, brain, adrenal glands, endothelium, and human plasma. It has function in vascular (control of blood pressure), cardiac (regulation of cell progenitors migration), brain (water and food intake), digesting (decrease in acid secretion by parietal cells, inhibits insulin secretion), and bone (expressed in cell progenitors involved in bone formation). APJ APJ PRO:000001120 Apelin receptor BAO_0200298 A member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] GPBAR1 GPBAR1 PRO:000001110 G protein-coupled bile acid receptor 1 BAO_0200299 The bombesin receptors are a group of G protein-coupled receptors which bind bombesin. Bombesin is a 14-amino acid peptide originally isolated from the skin of a frog. It has two known homologs in mammals called neuromedin B and gastrin-releasing peptide. It stimulates gastrin release from G cells. It activates three different G protein-coupled receptors known as BBR1, -2, and -3. It also activates these receptors in the brain. Together with cholecystokinin, it is the second major source of negative feedback signals that stop eating behavior. Bombesin receptor BAO_0200300 Class A GPCR whose principla ligans is protein bradykinin and mediate responses to inflammation, trauma, burns, shock and allergy. It also plays a role in cross-talk between the renin-angiotensin system and the kinin-kallikrein system. Bradykinin receptor BAO_0200301 The cannabinoid receptors are a class of cell membrane receptors under the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains. Cannabinoid receptors are activated by three major group of ligands, endocannabinoids (produced by the mammalian body), plant cannabinoids (such as THC, produced by the cannabis plant) and synthetic cannabinoids (such as HU-210). All of the endocannabinoids and plant cannabinoids are lipophilic, i.e. fat soluble, compounds. Cannabinoid receptor BAO_0200302 Class A GPCRs which interact with a type of cytokine called a chemokine. They are involved in chemotaxis which traffics the cell to a desired location within the organism. Chemokine receptor BAO_0200308 Class A GPCR that binds free fatty acids which come from the breakdown of triglycerides. FFA are transported while bound to albumin. Free fatty acid receptor BAO_0200311 Class A GPCRs with Its activation is necessary for the hormonal functioning during reproduction and thyroid function. Glycoprotein hormone receptor BAO_0200313 Class A GPCRs which are activated by the biogenic amine histamine, and expressed throughout the body, to be specific, in smooth muscles, on vascular endothelial cells, in the heart, and in the central nervous system. H1 modulatesileum contraction, modulate circadian cycle, itching, systemic vasodilatation, and bronchoconstriction (asthma). H2 speed up sinus rhythm, stimulates gastric acid secretion, smooth muscle relaxation, inhibits antibody synthesis, T-cell proliferation and cytokine production. H3 functions as a neurotransmitter in CNS, Presynaptic autoreceptors. H4 mediate mast cell chemotaxis. Histamine receptor BAO_0200314 The KiSS1-derived peptide receptor (also known as GPR54 or the Kisspeptin receptor) is a G protein-coupled receptor which binds the peptide hormone kisspeptin (metastin). Kisspeptin is encoded by the metastasis suppressor gene KISS1, which is expressed in a variety of endocrine and gonadal tissues. Activation of the kisspeptin receptor is linked to the phospholipase C and inositol trisphosphate second messenger cascades inside the cell. A rhodopsin-like G protein-coupled receptor that is a translation product of the KISS1R gene or a 1:1 ortholog thereof. The preferred ligands are peptides of 10-54 residues derived from the metastasis-suppressor KiSS-1 protein. [PRO:WCB, UniProtKB:Q15726] GPR54 KISS1R GPR54 KISS1R PRO:000001426 Kisspeptin receptor BAO_0200315 The cysteinyl leukotrienes are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, CUSLTR1 and CYSLTR2, members of the superfamily of G protein-coupled receptors. Activation of these receptors results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung. They play a major role in endocrine and cardiovascular systems. Leukotriene receptor BAO_0200316 The lysophospholipid receptor (LPL-R) group are members of the G protein-coupled receptor family of integral membrane proteins that are important for lipid signaling. In humans, there are eight LPL receptors, each encoded by a separate gene. These LPL receptor genes are also sometimes referred to as "Edg” (an acronym for endothelial differentiation gene). Lysophospholipid receptor BAO_0200317 Melanin-concentrating hormone receptors are members of the G protein-coupled receptor family 1, integral plasma membrane proteins which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. Melanin-concentrating hormone receptor BAO_0200318 Melanocortin receptors are members of the rhodopsin family of 7-transmembrane, G protein-coupled receptors. There are five known members of the melanocortin receptor system each with differing specificities for melanocortins: MC1R is associated with pigmentation genetics. MC2R is also known as the ACTH receptor or corticotropin receptor because it is specific for ACTH alone. MC3R. Defects in MC4R are a cause of autosomal dominant obesity, accounting for 6% of all cases of early-onset obesity. MC5R. These receptors are inhibited by endogenous inverse agonists agouti signaling peptide and agouti-related peptide, and activated by synthetic (i.e.: afamelanotide) and endogenous agonist melanocyte-stimulating hormones. Melanocortin receptor BAO_0200319 A melatonin receptor is a G protein-coupled receptor (GPCR) which binds melatonin. Three types of melatonin receptor have been cloned. The MT1 (or Mel1A or MTNR1A) and MT2 (or Mel1B or MTNR1B) receptor subtypes are present in humans and other mammals, while an additional melatonin receptor subtype MT3 (or Mel1C or MTNR1C) has been identified in amphibia and birds. Melatonin receptor BAO_0200321 The neuromedin U receptors are two G protein-coupled receptors which bind the neuropeptide hormones neuromedin U and neuromedin S. Neuromedin U (or NmU) is a neuropeptide found in the brain of humans and other mammals, which has a number of diverse functions including contraction of smooth muscle, regulation of blood pressure, pain perception, appetite, bone growth, and hormone release. Neuromedin S is a 36-amino acid neuropeptide found in the brain of humans and other mammals. It is produced in the suprachiasmatic nucleus of the hypothalamus and is related to neuromedin U. It is thought to be involved in regulation of circadian rhythm and also has appetite suppressant effects, as well as regulating the release of several other peptide hormones including vasopressin, luteinizing hormone, and oxytocin. Neuromedin U receptor BAO_0200322 The neuropeptide FF receptors are members of the G protein-coupled receptor superfamily of integral membrane proteins which bind the pain modulatory neuropeptides AF and FF. These neuropeptides are thought to be involved in modulation of opioid receptor function in the brain and spinal cord, and can either reduce or increase opioid receptor function depending which tissue they are released in, reflecting a complex role for neuropeptide FF in pain responses. Neuropeptide FF receptor BAO_0200323 Class A GPCR that binds neuropeptide S. Animal studies show that NPS suppresses anxiety and appetite, induces wakefulness and hyperactivity, including hyper-sexuality, and plays a significant role in the extinction of conditioned fear. It has also been shown to significantly enhance dopamine activity in the mesolimbic pathway. NPSR NPSR PRO:000001491 Neuropeptide S receptor BAO_0200324 The neuropeptide B/W receptors are members of the G protein-coupled receptor superfamily of integral membrane proteins which bind the neuropeptides B and W. These receptors are predominately expressed in the CNS and have a number of functions including regulation of the secretion of cortisol. Neuropeptide W/neuropeptide B receptor BAO_0200325 Neuropeptide Y receptors are a class of G protein-coupled receptors which are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide. These receptors are involved in control of a diverse set of behavioral processes including appetite, circadian rhythm, and anxiety. Activated neuropeptide receptors release the Gi subunit from the heterotrimeric G protein complex. The Gi subunit in turn inhibits the production of the second messenger cAMP from ATP. Neuropeptide Y receptor BAO_0200327 Class A GPCRs with physiological ligands of these receptors being the ketone body 3-hydroxy-butyrate, the metabolite 2-hydroxy-propanoate (lactate) as well as the beta-oxidation intermediate 3-hydroxy-octanoate. Thus, this receptor subfamily is activated by hydroxy-carboxylic acid ligands which are intermediates of energy metabolism. All three receptors are predominantly expressed in adipocytes and mediate antilipolytic effects. Hydroxycarboxylic acid receptors BAO_0200335 A prostanoid receptor, class A GPCR, is an integral membrane protein which detects the presence of eicosanoid signaling molecules consisting of: the prostaglandins (mediators of inflammatory and anaphylactic reactions), the thromboxanes (mediators of vasoconstriction) and the prostacyclins (active in the resolution phase of inflammation.) Prostanoid receptor BAO_0200336 Protease-activated receptors are a subfamily of related G protein-coupled receptors that are activated by cleavage of part of their extracellular domain. They are highly expressed in platelets, but also on endothelial cells, myocytes and neurons. Protease-activated receptor BAO_0200337 The relaxin receptors are a subclass of four closely related G protein-coupled receptors that bind relaxin peptide hormones. In males, relaxin enhances motility of sperm in semen. In females relaxin is produced mainly by the corpus luteum, in both pregnant and nonpregnant females. Relaxin family peptide receptor BAO_0200338 Class A GPCR binding a peptide hormone, somatostatin, that regulates the endocrine system and affects neurotransmission and cell proliferation and inhibition of the release of numerous secondary hormones. Somatostatin receptor BAO_0200339 There are three known mammalian tachykinin receptors termed NK1, NK2 and NK3. All are members of the 7 transmembrane G protein-coupled receptor family and induce the activation of phospholipase C, producing inositol triphosphate (so called Gq-coupled). Tachykinin receptor BAO_0200348 Corticotropin-releasing hormone receptors (CRHRs), also known as corticotropin-releasing factor receptors (CRFRs) are a G protein-coupled receptor family that binds corticotropin-releasing hormone (CRH). CRHRs are important mediators in the stress response. Corticotropin-releasing factor receptor BAO_0200349 The glucagon receptor is a 62 kDa protein that is activated by glucagon and is a member of the class B G protein-coupled family of receptors, coupled to G alpha i, Gs and to a lesser extent G alpha q. Glucagon receptor family BAO_0200350 There are two known parathyroid hormone receptors in mammals termed PTH1R and PTH2R. These receptors bind parathyroid hormone and are members of the GPCR family of transmembrane proteins. Parathyroid hormone receptor BAO_0200351 There are two known receptors for the vasoactive intestinal peptide (VIP) termed VPAC1 and VPAC2. These receptors bind both VIP and pituitary adenylate cyclase-activating polypeptide (PACAP) to some degree. Both receptors are members of the 7 transmembrane G protein-coupled receptor family. VPAC1 is distributed widely in the CNS, liver, lung, intestine and T-lymphocytes. VPAC2 is found in the CNS, pancreas, skeletal muscle, heart, kidney, adipose tissue, testis, and stomach. Pituitary adenylate cyclase-activating polypeptide type I receptor also known as PAC1, is a protein that in humans is encoded by the ADCYAP1R1 gene. This receptor binds pituitary adenylate cyclase activating peptide. VIP and PACAP receptor BAO_0200352 An orphan receptor of Class B is an apparent receptor that has a similar structure to other identified receptors but whose endogenous ligand has not yet been identified. Class B Orphan BAO_0200353 GABAB receptors (GABABR) are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA) that are linked via G proteins to potassium channels. These receptors are found in the central and peripheral autonomic nervous system. GABAB receptor BAO_0200354 The Retinoic Acid-Inducible orphan G protein-coupled receptors (RAIG) are a group of four closely related G protein-coupled receptors whose expression is induced by retinoic acid. Retinoic acid-inducible orphan GPCR BAO_0200370 A member of the EGF-TM7 receptor gene family which is thought to play a role in leukocyte adhesion and migration. In other vertebrates, including nonhuman primates, this gene encodes a protein containing N-terminal EGF domains and a C-terminal transmembrane domain. Sequence evidence for the human gene, however, indicates nucleotide deletion in the genomic sequence would result in frameshift and early termination of translation. A protein expressed by this gene would be soluble rather than expressed on the cell surface. As the encoded protein has not been detected, this gene may represent a transcribed pseudogene. [provided by RefSeq, Aug 2008] EMR4 FIRE GPR127 PGR16 EMR4 Egf-like module containing, mucin-like, hormone receptor-like 4 BAO_0200373 Probable G protein-coupled receptor 97 is a protein that in humans is encoded by the GPR97 gene. It is a member of the adhesion-GPCR family of receptors. PB99 PGR26 GPR97 G protein-coupled receptor 97 BAO_0200375 A protein that is a translation product of the Gpr110 gene or a 1:1 ortholog thereof. [PRO:DNx] FLJ22684 FLJ30646 KPG_012 MGC125952 PGR19 hGPCR36 GPR110 PRO:000008378 G protein-coupled receptor 110 BAO_0200376 Probable G protein-coupled receptor 111 is a protein that in humans is encoded by the GPR111 gene. PGR20 hGPCR35 GPR111 G protein-coupled receptor 111 BAO_0200377 Probable G protein-coupled receptor 112 is a protein that in humans is encoded by the GPR112 gene. The gene product is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. DKFZp781E1948 PGR17 RP1-299I16 GPR112 G protein-coupled receptor 112 BAO_0200378 Probable G protein-coupled receptor 113 is a protein that in humans is encoded by the GPR113 gene, FLJ16767 PGR23 hGPCR37 GPR113 G protein-coupled receptor 113 BAO_0200379 Probable G protein-coupled receptor 114 is a protein that in humans is encoded by the GPR114 gene. The gene product is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. PGR27 GPR114 G protein-coupled receptor 114 BAO_0200380 Probable G protein-coupled receptor 115 is a protein that in humans is encoded by the GPR115 gene. FLJ38076 PGR18 GPR115 G protein-coupled receptor 115 BAO_0200381 G protein-coupled receptor 116 DKFZp564O1923 FLJ90640 KIAA0758 KPG_001 GPR116 G protein-coupled receptor 116 BAO_0200383 Probable G protein-coupled receptor 124 is a protein that in humans is encoded by the GPR124 gene. DKFZp434C211 DKFZp434J0911 FLJ14390 KIAA1531 TEM5 GPR124 G protein-coupled receptor 124 BAO_0200384 Probable G protein-coupled receptor 125 is a protein that in humans is encoded by the GPR125 gene. PGR21 TEM5L GPR125 G protein-coupled receptor 125 BAO_0200385 Probable G protein-coupled receptor 126 is a protein that in humans is encoded by the GPR126 gene. This gene encodes a member of the adhesion-GPCR receptor family Family members are characterized by an extended extracellular region with a variable number of N-terminal protein modules coupled to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. It is involved in the process of myelination. APG1 DREG PS1TP2 VIGR GPR126 G protein-coupled receptor 126 BAO_0200386 Probable Yoi G protein-coupled receptor 128 is a protein that in humans is encoded by the GPR128 gene. It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. FLJ14454 FLJ16382 FLJ29035 MGC142011 MGC163260 GPR128 G protein-coupled receptor 128 BAO_0200387 Probable G protein-coupled receptor 133 is a protein that in humans is encoded by the GPR133 gene. This gene encodes a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. DKFZp434B1272 FLJ16770 MGC138512 MGC138514 PGR25 GPR133 G protein-coupled receptor 133 BAO_0200389 Probable G protein-coupled receptor 144 is a protein that in humans is encoded by the GPR144 gene. This gene encodes a member of the adhesion-GPCR family of receptors. Family members are characterised by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. PGR24 GPR144 G protein-coupled receptor 144 BAO_0200396 A protein that is a translation product of the GPRC5D gene or a 1:1 ortholog thereof. [PRO:DNx] GPRC5D MGC129713 MGC129714 RAIG4 PRO:000008197 GPCR family C group 5 member D BAO_0200405 Predicted G protein-coupled receptor 158 FLJ37801 KIAA1136 RP11-59G22.1 GPR158 G protein-coupled receptor 158 BAO_0200406 G protein-coupled receptor 179; similar to GPR158-like 1 (predicted). GPR158L1 GPR179 G protein-coupled receptor 179 BAO_0200407 A protein that is a translation product of the GPRC5B gene or a 1:1 ortholog thereof. [PRO:DNx] GPRC5B RAIG-2 RAIG2 RAIG2 PRO:000008195 GPCR family C group 5 member B BAO_0200408 A protein that is a translation product of the GPRC5C gene or a 1:1 ortholog thereof. [PRO:DNx] GPRC5C MGC131820 RAIG-3 RAIG3 RAIG3 PRO:000008196 GPCR family C group 5 member C BAO_0200409 Rhodopsin-like receptors are a widespread protein family that includes hormones, neurotransmitters, and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character, the amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7 transmembrane (TM) helices. Class A BAO_0200410 Class B of the GPCRs, the secretin-receptor family GPCRs, include vasoactive intestinal peptide receptors and receptors for secretin, calcitonin and parathyroid hormone/parathyroid hormone-related peptides. These receptors activate adenylyl cyclase and the phosphatidyl-inositol-calcium pathway. The receptors in this family have 7 transmembrane helices, like rhodopsin-like GPCRs. However, there is no significant sequence identity between these two GPCR families and the secretin-receptor family has its own characteristic 7TM signature. The secretin-receptor family GPCRs exist in many animal species, but have not been found in plants, fungi or prokaryotes. Three distinct sub-families (B1-B3) are recognized. Class B BAO_0200411 The class C G protein-coupled receptors are a class of G protein-coupled receptors that include the metabotropic glutamate receptors and several additional receptors. Class C BAO_0200412 An ATP-sensitive potassium channel is a type of potassium channel that is gated by ATP. ATP-sensitive potassium channels are composed of Kir6.x-type subunits and sulfonylurea receptor (SUR) subunits, along with additional components.[1] They can be further identified by their position within the cell as being either sarcolemmal ("sarcKATP"), mitochondrial ("mitoKATP"), or nuclear ("nucKATP"). ATP-sensitive inward rectifier potassium channel BAO_0200413 Addiction has been defined as physical and psychological dependence on psychoactive substances Addiction BAO_0200414 Adenylate cyclase (EC 4.6.1.1, also known as adenylyl cyclase, adenyl cyclase or AC) is part of the G protein signaling cascade, which transmits chemical signals from outside the cell across the membrane to the inside of the cell (cytoplasm). The outside signal binds to a receptor, which transmits a signal to the G protein, which transmits a signal to adenylate cyclase, which transmits a signal by converting adenosine triphosphate to cyclic adenosine monophosphate (cAMP). cAMP is known as a second messenger. Adenylate cyclase BAO_0200415 The binding of a drug to a receptor of a cell and triggering a response by the cell. An agonist often mimics the action of a naturally occurring substance. Agonist BAO_0200416 Allosteric modulation of a receptor results from the binding of allosteric modulators at a different site (a "regulatory site") from that of the endogenous ligand (an "active site") and enhances or inhibits the effects of the endogenous ligand. Allosteric regulation BAO_0200417 Antagonism refers to the blocking the action of an agonist. A receptor antagonist does not provoke a biological response itself upon binding to a receptor, but blocks agonist-mediated responses. Antagonist BAO_0200418 Nerves of the autonomic nervous system convey their messages to the appropriate end organs (blood vessels, viscera, etc.) by releasing transmitter substances to which the receptors of the target cells are responsive. The most important of these transmitters in the autonomic nervous system are acetylcholine and norepinephrine. Autonomic nervous system transmission BAO_0200419 Behavior refers to the actions and mannerisms made by organisms, systems, or artificial entities in conjunction with its environment, which includes the other systems or organisms around as well as the physical environment. It is the response of the system or organism to various stimuli or inputs, whether internal or external, conscious or subconscious, overt or covert, and voluntary or involuntary. A mood is a relatively long lasting emotional state. Moods differ from emotions in that they are less specific, less intense, and less likely to be triggered by a particular stimulus or event. Moods generally have either a positive or negative valence. In other words, people typically speak of being in a good mood or a bad mood. Unlike acute, emotional feelings like fear and surprise, moods often last for hours or days. Mood also differs from temperament or personality traits which are even longer lasting. Behavioral and mood regulation BAO_0200420 Endogenous ligand BAO_0200421 Cadherins (named for "calcium-dependent adhesion") are a class of type-1 transmembrane proteins. They play important roles in cell adhesion, ensuring that cells within tissues are bound together. They are dependent on calcium (Ca2+) ions to function. Cadherin BAO_0200422 Calmodulin (CaM) (an abbreviation for CALcium-MODULated proteIN) is a calcium-binding protein expressed in all eukaryotic cells. It can bind to and regulate a number of different protein targets, thereby affecting many different cellular functions. Calmodulin BAO_0200423 Physical and psychological dependence on cannabis sativa preparations. hashish, marijuana Cannabinoids addiction BAO_0200424 A GPCRs receptor type classifying it by the type of ligand they preferentially bind. Steroid related GPCRs bind ligands containing a steroid related functional group. steroid-related receptor type BAO_0200425 A GPCRs receptor type classifying it by the type of ligand they preferentially bind. Steroidergic GPCRs bind ligands containing a steroid. steroidergic receptor type BAO_0200426 A GPCRs receptor type classifying it by the type of ligand they preferentially bind. Proteinergic GPCRs bind ligands that are proteins. proteinergic receptor type BAO_0200427 A GPCRs receptor type classifying it by the type of ligand they preferentially bind. Peptidergic GPCRs bind ligands containing a peptide bond. peptidergic receptor type BAO_0200428 A GPCRs receptor type classifying it by the type of ligand they preferentially bind. Nucleotide-like GPCRs bind ligands that are nucleotide-like. nucleotide-like receptor type BAO_0200429 A GPCRs receptor type classifying it by the type of ligand they preferentially bind. Hormonergic GPCRs bind ligands that are hormones. hormonergic receptor type BAO_0200430 Hormone is a chemical released by a cell or a gland in one part of the body that sends out messages that affect cells in other parts of the organism. calcitonin, C5a anaphylatoxin, follicle-stimulating hormone (FSH), gonadotropin-releasing hormone (GnRH), neurokinin, thyrotropin-releasing hormone (TRH), and oxytocin Hormone BAO_0200431 GPCR receptor type classified by the type of ligand they preferentially bind. Aminergic GPCRs bind ligands containing an amine group. aminergic receptor type BAO_0200434 Gq protein or Gq/11 is a heterotrimeric G protein subunit that activates phospholipase C (PLC). PLC in turn hydrolyzes Phosphatidylinositol 4,5-bisphosphate (PIP2) to diacyl glycerol (DAG) and inositol triphosphate (IP3) signal transduction pathway. DAG acts as a second messenger that activates Protein Kinase C (PKC) and IP3 helps in phosphorylation of some proteins. alpha q/11 BAO_0200438 Inhalants are drugs that produce chemical vapors which, as the name suggests, are inhaled. These drugs care found in common household products such as cleaning supplies; hairspray and beauty products and can have extremely powerful and dangerous effects. These drugs, while they are easy to acquire, still have the ability to be harmful on a person’s mind and body because they are not made of human consumption. Inhalants are mind altering, meaning they change the brain’s chemistry, and in effect, change the way a person feels, as well as the way his/her body functions. volatile hydrocarbons, petroleum derivatives Volatile solvents addiction BAO_0200446 Social status is the honor or prestige attached to one's position in society. Stress and social status BAO_0200447 Stimulants are a large category of drugs that range from various types of amphetamines to cocaine, crack and other medicines. Stimulants speed up the activity within a person’s body and brain and produce feelings of increased awareness and concentration. Common amphetamines include speed and crystal meth; these drugs may be referred to as uppers, ice and meth. amphetamine, cocaine, nicotine Stimulants addiction BAO_0200448 Smoothened is a G protein-coupled receptor protein encoded by the SMO gene of the hedgehog pathway conserved from flies to humans. It is the molecular target of the teratogen cyclopamine. SMO SMO PRO:000015288 Smoothened receptor BAO_0200449 Rho small GTPase Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and constitute a superfamily consisting of more than 100 members. This superfamily is structurally classified into at least five families: the Ras, Rho, Rab, Sar1/Arf, and Ran families. They regulate a wide variety of cell functions as biological timers (biotimers) that initiate and terminate specific cell functions and determine the periods of time for the continuation of the specific cell functions. They furthermore play key roles in not only temporal but also spatial determination of specific cell functions. The Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. Many upstream regulators and downstream effectors of small G proteins have been isolated, and their modes of activation and action have gradually been elucidated. Cascades and cross-talks of small G proteins have also been clarified. Small GTP-binding protein BAO_0200450 The primary g protein alpha associated with the receptor (q, s, i (1,2,3,o,T,gust), 12/13, Rho) 20 known Galpha 6 known Gbeta 11 known Ggamma q => PLCbeta (PIP2 = IP3 + DAG), PKC, PYK2, MAPK s => AC (inc cAMP), PKA i => AC (dec cAMP), MAPK, c-Src to STAT3 and Rap pathways o => PL and PDE, c-Src to STAT3 and Rap pathways Signaling pathway transducer BAO_0200451 Signaling pathway, effectors and pathway transducer identifying specific GPCR signal transmission pathway. During GPCR signaling the activated G protein subunits detaches from the receptor and initiates signaling from many downstream effector proteins such as phospholipases and ion channels, the latter permitting the release of second messenger molecules. The total strength of signal amplification by a GPCR is determined by the lifetimes of the ligand-receptor complex and receptor-effector protein complex and the deactivation time of the activated receptor and effectors through intrinsic enzymatic activity. Signaling pathway effector identifies the second messenger in the signaling cascade (adenylate cyclase, calcium-, potassium-channels, cAMP, PLC, PDE, etc) G alpha q => PLCbeta (PIP2 = IP3 + DAG), PKC, PYK2, MAPK G alpha s => AC (inc cAMP), PKA G alpha i => AC (dec cAMP), MAPK, c-Src to STAT3 and Rap pathways G alpha o => PL and PDE, c-Src to STAT3 and Rap pathways Signaling pathway effector BAO_0200452 The preferred primary and secondary receptor signal transduction pathway or mechanism. Signaling pathway BAO_0200453 Receptor function refers to the processes GPCRs participates at physiological or molecular level. Receptor function BAO_0200454 GPCR kinase, kinase suppressor of Ras(KSR), PKC, RAF protein kinase, MAPK Serine/threonine protein kinases (EC 2.7.11.1) phosphorylate the OH group of serine or threonine (which have similar sidechains). Ser Thr protein kinase BAO_0200455 A sensory system is a part of the nervous system responsible for processing sensory information. A sensory system consists of sensory receptors, neural pathways, and parts of the brain involved in sensory perception. Commonly recognized sensory systems are those for vision, hearing, somatic sensation (touch), taste and olfaction (smell). In short, senses are transducers from the physical world to the realm of the mind. Sensory system function BAO_0200456 Neurologic diseases are disorders of the brain, spinal cord and nerves throughout the body. Any involuntary behavior that occurs abnormally may represent a seizure. Seizures may be caused by situations within the brain (such as trauma or infection) or by situations centered outside the brain (such as low blood sugar, circulating metabolic toxins, or external poisons). Seizures and neurologic disorder BAO_0200457 The preferred secondary receptor signaling pathways or mechanisms, where established. Secondary signaling pathway BAO_0200458 The alpha-factor receptor of yeast. [Marsh L, PNAS '88 V85, p.3855] ste3 STE3 alpha-factor BAO_0200459 Fungal pheromone mating factor STE2 GPCR family protein CPC735_060100 STE2 STE2 alpha-factor BAO_0200460 Signaling adapter that couples activated growth factor receptors to signaling pathway SHC transforming protein BAO_0200461 Addiction towards prescribed medicines. The most commonly abused prescription drugs are opioids, depressants and stimulants. While all of these drugs produce drastically different effects, they all have the ability to change a person’s state of mind by altering the brain’s chemistry. muscle relaxant, painkillers, anti histamines, anti emetics, anti depressants, anti psychotics Prescription and over the counter drug abuse BAO_0200462 The function of the respiratory system is to allow gas exchange it, taking oxygen into the blood and removing carbon dioxide from the blood. It includes thermoregulation Respiratory function BAO_0200463 The transport of oxygen from the outside air to the cells within tissues, and the transport of carbon dioxide in the opposite direction. Respiration BAO_0200464 The function of the reproductive system is to produce new offspring. The continuity of the species is guaranteed through reproduction. Reproductive function BAO_0200465 Regulators of G protein signaling (or RGS) are protein structural domains that activate GTPases for heterotrimeric G protein alpha-subunits. RGS are multi-functional, GTPase-accelerating proteins that promote GTP hydrolysis by the alpha subunit of heterotrimeric G proteins, thereby inactivating the G protein and rapidly switching off G protein-coupled receptor signaling pathways. Upon activation by GPCRs, heterotrimeric G proteins exchange GDP for GTP, are released from the receptor, and dissociate into free, active GTP-bound alpha subunit and beta-gamma dimer, both of which activate downstream effectors. The response is terminated upon GTP hydrolysis by the alpha subunit, which can then bind the beta-gamma dimer and the receptor. RGS proteins markedly reduce the lifespan of GTP-bound alpha subunits by stabilizing the G protein transition state. All RGS proteins contain an RGS-box (or RGS domain), which is required for activity. Some small RGS proteins such as RGS1 and RGS4 are little more than an RGS domain, while others also contain additional domains that confer further functionality. Regulator of G protein signaling BAO_0200466 Classification of GPCR types based on the type of ligand they preferentially bind. Receptor type BAO_0200467 Amine ligand BAO_0200468 Indicates that the ligand also binds to other receptors in the database. Promiscuous BAO_0200469 The preferred primary receptor signaling pathways or mechanisms, where established. Primary signaling pathway BAO_0200470 The response of the living system to carry out chemical and/or physical processes. Physiological function BAO_0200471 Phospholipase C (PLC) is a class of enzymes that cleave phospholipids just before the phosphate group. It is most commonly taken to be synonymous with the human forms of this enzyme, which play an important role in eukaryotic cell physiology, in particular signal transduction pathways. Thirteen kinds of mammalian phospholipase C are classified into six isotypes (β, γ, δ, ε, ζ, η) according to structure. Phospholipase C BAO_0200473 Partial agonists (such as buspirone, aripiprazole, buprenorphine, or norclozapine) also bind and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist. Partial agonist BAO_0200474 The somatosensory system is a diverse sensory system composed of the receptors and processing centres to produce the sensory modalities such as touch, temperature, proprioception (body position), and nociception (pain). The sensory receptors cover the skin and epithelia, skeletal muscles, bones and joints, internal organs, and the cardiovascular system. While touch (also, more formally, tactition; adjectival form: "tactile" or "somatosensory") is considered one of the five traditional senses, the impression of touch is formed from several modalities. In medicine, the colloquial term touch is usually replaced with somatic senses to better reflect the variety of mechanisms involved. Somatosensory sensation BAO_0200477 An oligomer is a molecule that consists of a few monomer units. The very close proximity of two or more receptors has been demonstrated unambiguously in heterologous cell systems for several GPCRs using biochemical and biophysical techniques (Milligan and Bouvier, 2005) supporting the existence of functionally relevant GPCR dimers/oligomers. Oligomer BAO_0200478 Olfaction (also known as olfactics; adjectival form: "olfactory") is the sense of smell. This sense is mediated by specialized sensory cells of the nasal cavity of vertebrates, and, by analogy, sensory cells of the antennae of invertebrates. Many vertebrates, including most mammals and reptiles, have two distinct olfactory systems—the main olfactory system, and the accessory olfactory system (mainly used to detect pheromones). Olfactory sensation BAO_0200479 The nervous system is one of the major regulatory systems of the body maintaining homeostasis. Its functions are to: 1) monitor the body's internal and external environments; 2) integrate sensory information; and 3) direct or coordinate the responses of other organ systems to the sensory input. Nervous system function BAO_0200480 Opiates are drugs that all come from a liquid from a poppy plant called opium. A surprising number of narcotics come from the poppy including morphine, heroin and codeine. You may recognize morphine and codeine from our prescription drug abuse pages but prescriptions are synthetic or man-made versions of what is naturally found in the poppy plant. Heroin, morphine, codeine and all other synthetic opiates affect the brains reward system and blocks pain center which explains why opiate users do not feel hunger and often lack proper nutrition. Other physical consequences of consistent opiate use are dependence, infection of the heart, liver disease and breathing problems. Even individuals using opiates for the first time are at tremendous risk of over dosing and death if they use an amount large enough to stop breathing. Opiate addiction occurs when the brain begins to require the drug in order to function “normally.” The withdrawal symptoms from opiates are some of the most devastating of all drugs in terms of feeling terribly sick. Heroin and other types of opiate users find that they must use the drug quite frequently just to feel right and function. This can set opiate addicts apart from other drug users whose consequences are often more obvious. Opiate addicts tend to be more secretive about their using and can go undetected for years. opium, morphine, codeine, heroin, buprenorphine, methadone, pentazocine Narcotic Analgesiscs addiction BAO_0200481 The major functions of the skeletal system are: Protection, Structure, Motility, Calcium reserves, Blood cell formation. The major functions of the muscular system are: 1. Body movement due to the contraction of skeletal muscles 2. Maintenance of posture also due to skeletal muscles 3. Respiration due to movements of the muscles of the thorax 4. -Production of body heat, which is necessary for the maintenance of body temperature, as a byproduct of muscle contraction 5. -Communication, such as speaking and writing, which involve skeletal muscles 6. -Constriction of organs and vessels, especially smoother muscles that can move solids and liquids in the digestive tract and other secretions, including urine, from organs 7. -Heart beat caused by the contraction of cardiac muscle that propels blood to all parts of the body Muscokeletal function BAO_0200482 Synthetic small molecule ligand BAO_0200483 A mental disorder or mental illness is a psychological or behavioral pattern generally associated with subjective distress or disability that occurs in an individual, and which is not a part of normal development or culture. Such a disorder may consist of a combination of affective, behavioral, cognitive and perceptual components. Mental illness BAO_0200484 The mechanism by which a pharmacologically-active substance produces an effect on a living organism or in a biochemical system. Mechanism of action BAO_0200485 Mitogen-activated protein (MAP) kinases (EC 2.7.11.24) are serine/threonine-specific protein kinases that respond to extracellular stimuli (mitogens, osmotic stress, heat shock and proinflammatory cytokines) and regulate various cellular activities, such as gene expression, mitosis, differentiation, proliferation, and cell survival/apoptosis. MAPK BAO_0200486 Compounds are assigned to classes based on their chemical and structural properties: Synthetic compounds Low molecular weight, non-polymeric compounds produced via either total synthesis or semi-synthetic processes. Small organic molecules Low molecular weight, non-peptidic, biogenic compounds produced by life processes (normally endogenous and of animal origin) and their close analogues. Peptides Synthetic, semi-synthetic and natural short polymers of amino acids linked by peptide bonds (oligopeptides and cyclic peptides). Inorganic compounds Ions and other inorganic compounds. Lipids a broad group of naturally occurring molecules which include fats, waxes, sterols, fat-soluble vitamins (such as vitamins A, D, E and K), monoglycerides, diglycerides, phospholipids, and others. The main biological functions of lipids include energy storage, as structural components of cell membranes, and as important signaling molecules. Amine organic compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are derivatives of ammonia, wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group. Hormone a chemical released by a cell or a gland in one part of the body that sends out messages that affect cells in other parts of the organism. Ligand chemical type BAO_0200490 Inwardly rectifying potassium channels (Kir, IRK) are a specific subset of potassium selective ion channels. To date, seven subfamilies have been identified in various mammalian cell types. They are the targets of multiple toxins, and malfunction of the channels has been implicated in several diseases. Inward rectifier potassium ion channel BAO_0200491 Inverse agonism is the binding of a perturbagen to the same receptor binding-site as an agonist for that receptor and reversing the constitutive activity of receptors. Inverse agonists exert the opposite pharmacological effect of a receptor agonist. Inverse agonist BAO_0200492 The function of the immune system is to protect body from infections and illnesses. Immune function BAO_0200493 Hormone ligand BAO_0200494 An oligomer consisting of two identical monomeric proteins. Identifies protomers, receptors associating with the same receptors (i.e. MOR-MOR). A propensity of certain GPCRs to dimerize with themselves. Homomer BAO_0200495 An oligomer consisting of two different monomeric proteins. Identifies protomeris, receptors that make up an oligomer (i.e. MOR-DOR). Heteromer BAO_0200496 Drugs are considered hallucinogens if they are able to produce hallucinations in a person’s mind. A hallucination can be defined as a false interpretation or image through any of the various senses. Most commonly hallucinogens produce visual and auditory hallucinations where users hear or see things that do not really exist. These drugs, like all other illicit drugs, are mood- and mind- altering chemicals that, over time, can change a person’s mental and physical capacities. Hallucinogens exist naturally and they can also be produced synthetically. Some of the most common hallucinogens include LSD, also known as acid, mushrooms, PCP, and mescaline. There are thousands of synthetically produced hallucinogens which can cause physical and mental problems even if only used once. Other drugs that are not usually considered hallucinogens, such as marijuana and ecstasy can produce hallucinations if taken in large enough doses. LCD, PCP, mescaline, psilocybin Hallucinogens addiction BAO_0200497 RhoGEFs, Synembryns Guanine nucleotide exchange factors (GEFs) activate monomeric GTPases by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP). A variety of unrelated structural domains have been shown to exhibit guanine nucleotide exchange activity. Some GEFs can activate multiple GTPases while others are specific to a single GTPase. Guanine nucleotide exchange factor BAO_0200498 Ras specific nucleotide releasing factors Guanine nucleotide releasing factor (GRF) accelerate release of GDP and subsequent rebinding of GTP to Ras and Rapl proteins. Guanine nucleotide releasing factor BAO_0200499 The act of self-propulsion, travel, moving from point A to B. General activity and locomotion BAO_0200500 Ligands that inhibit ion channel gating by directly binding to the channels, including ligands that inhibit ion channel activation and those that inhibit ion channel inactivation. Gating inhibition BAO_0200501 The main function of the renal system is to get rid of waste that is found in the urine. Hepatic portal system allows the liver to get a first chance at making metabolic decisions on whether the body is in the well-fed or fasting states. Subsequent insulin or glucagon secretion will then put the body into either a glucose sparing or glucose storing mode. Liver is the primary cleansing and detoxifying organ of the body. Gastrointestinal, renal and hepatic function BAO_0200502 The primary effectors of Gβγ are various ion channels, such as G protein-regulated Inwardly Rectifying K+ channels (GIRKs), P/Q- and N-type voltage-gated Ca2+ Channels, as well as some isoforms of AC and PLC, along with some Phosphoinositide-3-Kinase (PI3K) isoforms. The beta-gamma complex is composed of the heterotrimeric G proteins Gβ (beta subunit) and Gγ (gamma subunit) that are closely bound to one another. Upon activation of a G protein-coupled receptor, the Gβγ complex is released from the Gα subunit, allowing the Gα subunit to function as a messenger in signal transduction. The normal role of the beta-gamma complex is inhibition of the Gα subunit. However, the free Gβγ complex can act as a signaling molecule itself, by activating other second messengers or by gating ion channels directly. Examples of Gβγ complex functions include: Activation of phospholipase A2 when bound to histamine receptors; Direct opening of G protein-coupled inward rectifying potassium channels (GIRKs) when bound to muscarinic acetylcholine receptors; Activation L-type calcium channels, as in H3 receptor pharmacology. Initiation of the phospholipase C pathway by activating phospholipase C, as a minor mechanism of growth hormone releasing hormone releasing growth hormone. G protein beta/gamma BAO_0200503 G proteins (guanine nucleotide-binding proteins) are a family of proteins involved in transmitting chemical signals outside the cell, and causing changes inside the cell. They communicate signals from many hormones, neurotransmitters, and other signaling factors. Receptor-activated G proteins are bound to the inside surface of the cell membrane. They consist of the Gα and the tightly associated Gβγ subunits. There are many classes of Gα subunits: Gsα (G stimulatory), Giα (G inhibitory), Goα (G other), Gq/11α, and G12/13α are some examples. They behave differently in the recognition of the effector, but share a similar mechanism of activation. G protein alpha BAO_0200504 The three main functions of the cardiovascular system are to: carry oxygen around the body, get rid of waste products e.g. carbon dioxide, and modulate heat thermoregulation. Cardiovascular function BAO_0200505 Caveolins are a family of integral membrane proteins which are the principal components of caveolae membranes and involved in receptor-independent endocytosis. Caveolins may act as scaffolding proteins within caveolar membranes by compartmentalizing and concentrating signaling molecules. Various classes of signaling molecules, including G protein subunits, receptor and non-receptor tyrosine kinases, endothelial nitric oxide synthase (eNOS), and small GTPases, bind Cav-1 through its 'caveolin-scaffolding domain'. Caveolin BAO_0200506 A type of molecule which binds inside the pore of a specific type of ion channel and blocks the flow of ions through it, resulting in an alteration of the electrochemical gradient of the cell membrane of neurons and therefore a change in neurotransmission. Channel blocker BAO_0200507 Lipid ligand BAO_0200508 Fungal pheromone mating factor receptors form a distinct family of G protein-coupled receptors. Mating factor receptors STE2 and STE3 are integral membrane proteins that may be involved in the response to mating factors on the cell membrane. Class D BAO_0200509 Class E comprises of GPCRs called cyclic AMP receptors from slime molds. These receptors control development in Dictyostelium discoideum. The cyclic AMP receptors coordinate aggregation of individual cells into a multicellular organism, and regulate the expression of a large number of developmentally-regulated genes Class E BAO_0200510 Class F of the GPCRs encompasses frizzled and smoothened family of receptors. Class F BAO_0200511 Any untoward medical occurrence in a patient or clinical investigation subject administered a pharmaceutical product and which does not necessarily have to have a causal relationship with this treatment. Clinical adverse effect BAO_0200512 A cyclase is an enzyme, almost always a lyase, that catalyzes a chemical reaction to form a cyclic compound. Cyclase BAO_0200513 Slime mold (D. discoideum) cAMP receptors. Dictyostelium discoideum is a species of soil-living amoeba belonging to the phylum Mycetozoa. D. discoideum, commonly referred to as slime mold, is a eukaryote that transitions from a collection of unicellular amoebae into a multicellular slug and then into a fruiting body within its life time. crp CRP PRO:000022333 Catabolite gene activator Cyclic AMP receptor BAO_0200514 Depressants cover a large range of drugs including marijuana, alcohol, and barbiturates. The most commonly used and abused depressant is alcohol, which is taken orally, and can lead to addiction and serious health complications such as liver disease. Most depressants are taken orally however some barbiturate users inject drugs intravenously. There are many side effects of depressants, which include reduced inhibitions, inability to concentrate and pay attention for any period of time, impaired judgment and an inability to control one’s emotions. Just as the drugs’ name suggests people who used depressants often feel depressed and suicidal as a result. alcohol, barbiturates, benzodiazepines Depressants addiction BAO_0200515 Dynamin is a GTPase responsible for endocytosis in the eukaryotic cell. Dynamins are principally involved in the scission of newly formed vesicles from the membrane of one cellular compartment and their targeting to, and fusion with, another compartment, both at the cell surface (particularly caveolae internalization) as well as at the Golgi apparatus. Dynamin also plays a role in many processes including division of organelles, cytokinesis and microbial pathogen resistance. Dynamin BAO_0200516 Neurophysiology is the study of nervous system function. The primary tools of basic neurophysiological research include electrophysiological recordings such as patch clamp and calcium imaging, as well as some of the common tools of molecular biology. Electrical-related activity and neurophysiology BAO_0200517 The endocrine system is the main chemical-regulating system of an organism. Hormones, chemicals made and secreted by endocrine glands or neurosecretory cells, are the main messengers of the endocrine system. Hormones are transported in the blood to all parts of the body and interact with target cells (cells that contain hormone receptors), and they regulate metabolic rate, growth, maturation, and reproduction. Endocrine function BAO_0200518 Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) is an adapter protein which has been shown to play an active role in a wide variety of cellular processes, including interactions with proteins related to both tumor suppression and oncogenesis. Ezrin-Radixin-Moesin-Binding phosphoprotein BAO_0200519 A G protein-coupled receptor frizzled that is a translation product of the FZD1 gene or a 1:1 ortholog thereof. [PRO:DNx] DKFZp564G072 FLJ95923 FZD1 PRO:000007718 Frizzled-1 receptor BAO_0200520 A G protein-coupled receptor frizzled that is a translation product of the FZD10 gene or a 1:1 ortholog thereof. [PRO:CNA] CD350 FZ-10 Fz10 FzE7 hFz10 FZD10 PRO:000001453 Frizzled-10 receptor BAO_0200521 A G protein-coupled receptor frizzled that is a translation product of the FZD2 gene or a 1:1 ortholog thereof. [PRO:DNx] Fz2 fz-2 fzE2 hFz2 FZD2 PRO:000007719 Frizzled-2 receptor BAO_0200522 A G protein-coupled receptor frizzled that is a translation product of the FZD3 gene or a 1:1 ortholog thereof. [PRO:DNx] Fz-3 FZD3 PRO:000007720 Frizzled-3 receptor BAO_0200523 A G protein-coupled receptor frizzled that is a translation product of the FZD4 gene or a 1:1 ortholog thereof. [PRO:CNA] CD344 EVR1 FEVR FZD4S Fz-4 FzE4 GPCR MGC34390 FZD4 PRO:000001454 Frizzled-4 receptor BAO_0200524 A G protein-coupled receptor frizzled that is a translation product of the FZD5 gene or a 1:1 ortholog thereof. [PRO:DNx] C2orf31 DKFZp434E2135 HFZ5 MGC129692 FZD5 PRO:000007721 Frizzled-5 receptor BAO_0200525 A G protein-coupled receptor frizzled that is a translation product of the FZD6 gene or a 1:1 ortholog thereof. [PRO:DNx] FZ6 HFZ6 FZD6 PRO:000007722 Frizzled-6 receptor BAO_0200526 A G protein-coupled receptor frizzled that is a translation product of the FZD7 gene or a 1:1 ortholog thereof. [PRO:DNx] FzE3 FZD7 PRO:000007723 Frizzled-7 receptor BAO_0200527 A G protein-coupled receptor frizzled that is a translation product of the FZD8 gene or a 1:1 ortholog thereof. [PRO:DNx] FZ-8 hFZ8 FZD8 PRO:000007724 Frizzled-8 receptor BAO_0200528 A G protein-coupled receptor frizzled that is a translation product of the FZD9 gene or a 1:1 ortholog thereof. [PRO:CNA] CD349 FZD3 FZD9 PRO:000001455 Frizzled-9 receptor BAO_0200529 Frizzled is a family of G protein-coupled receptor proteins that serve as receptors in the Wnt signaling pathway and other signaling pathways. When activated, Frizzled leads to activation of Dishevelled in the cytosol. Frizzled receptor BAO_0200530 Full agonists bind (have affinity for) and activate a receptor, displaying full efficacy (the relative ability of a drug-receptor complex to produce a maximum functional response) at that receptor. Full agonist BAO_0200531 Receptor for the peptide pheromone alpha factor, the mating factor of yeast. Fungal mating pheromone receptor BAO_0200532 GRIN1 (Gprin 1) is a signaling molecule coexpression of which with constitutively active form of Galphao can stimulate neurite extensions in neuronal cells. GPRIN2 GPRIN2 GRIN2 PRO:000008200 G protein-regulated inducer of neurite outgrowth BAO_0200533 Rap-specific GAPs, Ras GTPase activating proteins GTPase-Activating Proteins, or GAPs, or GTPase-Accelerating Proteins are a family of regulatory proteins whose members can bind to activated G proteins and stimulate their GTPase activity, with the result of terminating the signaling event. GTPase activating protein BAO_0200534 A member of the lysophosphatidic acid receptor family. It may also be related to the P2Y receptors, a family of receptors that bind purine and pyrimidine nucleotides and are coupled to G proteins. The encoded protein may play a role in monocytic differentiation. [provided by RefSeq, Feb 2009] LPAR4 GPR23 LPAR4 PRO:000001598 Lysophosphatidic acid receptor 4 BAO_0200535 A rhodopsin-like G protein-coupled receptor that is a translation product of the LPAR5 gene or a 1:1 ortholog thereof. The reported ligand is lysophaphatidic acid. It is currently classed as an orphan receptor. This receptor is not closely related to other lysophosphatidic acid receptors. [PMID:16651401, PRO:WCB] LPAR5 GPR92 LPAR5 PRO:000001486 Lysophosphatidic acid receptor 5 BAO_0200536 Opsins are a group of light-sensitive 35–55 kDa membrane-bound G protein-coupled receptors of the retinylidene protein family found in photoreceptor cells of the retina. Five classical groups of opsins are involved in vision, mediating the conversion of a photon of light into an electrochemical signal, the first step in the visual transduction cascade. Another opsin found in the mammalian retina, melanopsin, is involved in circadian rhythms and pupillary reflex but not in image-forming. Opsin receptor BAO_0200537 Trace amine-associated receptors, abbreviated TAAR and otherwise known as trace amine receptors, abbreviated TAR or TA, are a class of G protein-coupled receptors identified in 2001. These receptors have gained considerable interest in academic and pharmaceutical industry research as putative endogenous receptors for trace amines, metabolic derivatives of classical biogenic amines and the psychostimulants amphetamine and methamphetamine. In 2004 it was shown that in mammals TAAR1 is probably a receptor for thyronamines, decarboxylated and deiodinated metabolites of the thyroid hormones, while the mouse mTAAR2 - mTAAR9 receptors are most probably olfactory receptors for volatile amines. Trace amine-associated receptor BAO_0200538 A trace amine-associated receptor 6-9 that is a translation product of the TAAR7 related paralogs (TAAR7A-F). There have been independent lineage-specific expansions of the TAAR7 gene in rat and mouse. It is a pseudogene in human. They are orphan receptors. [PRO:WCB] TAAR7 PRO:000001716 Trace amine-associated receptor 7 BAO_0200539 Data measuring the biological effect of a compound, e.g. % cell death, activation of reporter gene expression, inhibition of enzyme activity, etc. Ligand characteristic BAO_0200540 Peptide ligand BAO_0200541 Hormonergic receptor BAO_0200542 GPCR receptor type classified by the type of ligand they preferentially bind. A class of purinergic receptors with adenosine as endogenous ligand. adenosine receptor type BAO_0200543 GPCR receptor type classified by the type of ligand they preferentially bind. A class of GPCRs which detect the presence of eicosanoid signaling molecules. prostanoid receptor type BAO_0200544 Lipidergic receptor BAO_0200545 Peptidergic receptor BAO_0200546 Receptor function refers to the processes GPCRs participates at biological level. Oligomer s physiological significance Receptor biological process BAO_0200547 Molecular function describes activities, such as catalytic or binding activities, that occur at the molecular level. Molecular function BAO_0200548 Signaling pathway level, second messengers, and G proteins involved in GPCR signal cascade. Receptor signaling description BAO_0200549 Receptor signaling refers to the process of relaying events that occur at the cell surface via GPCR, ligands, second messenger and effector proteins. receptor signaling BAO_0201000 Olfactory receptors expressed in the cell membranes of olfactory receptor neurons are responsible for the detection of odor molecules. Activated olfactory receptors are the initial player in a signal transduction cascade which ultimately produces a nerve impulse which is transmitted to the brain. These receptors are members of the class A rhodopsin-like family of G protein-coupled receptors (GPCRs). The olfactory receptors form a multigene family consisting of over 900 genes in humans and 1500 genes in mice. Olfactory receptor BAO_0201001 A protein that is a translation product of the human OR5I1 gene or a 1:1 ortholog thereof. [PRO:DNx] HSOlf1 OR5I1 OR5I1 PRO:000011934 Q13606 Olfactory receptor 5I1 BAO_0201002 A protein that is a translation product of the human OR52J3 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-32 OR52J3 OR52J3 PRO:000011893 Q8NH60 Olfactory receptor 52J3 BAO_0201003 A protein that is a translation product of the human OR51L1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-31 OR51L1 OR51L1 PRO:000011874 Q8NGJ5 Olfactory receptor 51L1 BAO_0201004 A protein that is a translation product of the human OR51A7 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-27 OR51A7 OR51A7 PRO:000011859 Q8NH64 Olfactory receptor 51A7 BAO_0201005 A protein that is a translation product of the human OR51S1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-24 OR51S1 OR51S1 PRO:000011877 Q8NGJ8 Olfactory receptor 51S1 BAO_0201006 A protein that is a translation product of the human OR51F2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-23 OR51F2 OR51F2 PRO:000011868 Q8NH61 Olfactory receptor 51F2 BAO_0201007 A protein that is a translation product of the human OR52R1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-22 OR52R1 OR52R1 PRO:000011902 Q8NGF1 Olfactory receptor 52R1 BAO_0201008 A protein that is a translation product of the human OR4X2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-105 OR4X2 OR4X2 PRO:000011856 Q8NGF9 Olfactory receptor 4X2 BAO_0201009 A protein that is a translation product of the human OR4B1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-106 OR4B1 OR4B1 PRO:000011812 Q8NGF8 Olfactory receptor 4B1 BAO_0201010 A protein that is a translation product of the human OR52M1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-11 OR52M1 OR52M1 PRO:000011897 Q8NGK5 Olfactory receptor 52M1 BAO_0201011 A protein that is a translation product of the human OR52K2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-7 OR52K2 OR52K2 PRO:000011895 Q8NGK3 Olfactory receptor 52K2 BAO_0201012 A protein that is a translation product of the human OR5P2 gene or a 1:1 ortholog thereof. [PRO:DNx] JCG3 OR5P2 OR5P2 PRO:000011948 Q8WZ92 Olfactory receptor 5P2 BAO_0201013 A protein that is a translation product of the human OR5P3 gene or a 1:1 ortholog thereof. [PRO:DNx] JCG1 OR5P3 OR5P3 PRO:000011949 Q8WZ94 Olfactory receptor 5P3 BAO_0201014 A protein that is a translation product of the human OR8I2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-170 OR8I2 OR8I2 PRO:000012010 Q8N0Y5 Olfactory receptor 8I2 BAO_0201015 A protein that is a translation product of the human OR2D3 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-89 OR2D3 OR2D3 PRO:000011763 Q8NGH3 Olfactory receptor 2D3 BAO_0201016 A protein that is a translation product of the human OR2D2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-610 OR2D2 OR2D2 PRO:000011762 Q9H210 Olfactory receptor 2D2 BAO_0201017 A protein that is a translation product of the human OR52W1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-71 OR52W1 OR52W1 PRO:000011903 Q6IF63 Olfactory receptor 52W1 BAO_0201018 A protein that is a translation product of the human OR56A4 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-49 OR56A4 OR56A4 PRO:000011906 Q8NGH8 Olfactory receptor 56A4 BAO_0201019 A protein that is a translation product of the human OR56A1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-75 OR56A1 OR56A1 PRO:000011904 Q8NGH5 Olfactory receptor 56A1 BAO_0201020 A protein that is a translation product of the human OR2AP1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR2AP1 OR2AP1P OR2AP1 PRO:000011755 Q8NGE2 Olfactory receptor 2AP1 BAO_0201021 A protein that is a translation product of the human OR10P1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR10P1 OR10P1P OR10P1 PRO:000011678 Q8NGE3 Olfactory receptor 10P1 BAO_0201022 A protein that is a translation product of the human OR10AD1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR10AD1 OR10AD1P OR10AD1 PRO:000030899 Q8NGE0 Olfactory receptor 10AD1 BAO_0201023 A protein that is a translation product of the human OR10A7 gene or a 1:1 ortholog thereof. [PRO:DNx] OR10A7 OR12-6 OR10A7 PRO:000011658 Q8NGE5 Olfactory receptor 10A7 BAO_0201024 A protein that is a translation product of the human OR4K14 gene or a 1:1 ortholog thereof. [PRO:DNx] OR14-18 OR4K14 OR4K14 PRO:000011840 Q8NGD5 Olfactory receptor 4K14 BAO_0201025 A protein that is a translation product of the human OR4L1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR14-28 OR4L1 OR4L1 PRO:000011845 Q8NH43 Olfactory receptor 4L1 BAO_0201026 A protein that is a translation product of the human OR4D2 gene or a 1:1 ortholog thereof. [PRO:DNx] BC2009 OR4D2 OR4D2 P58180 PRO:000011826 Olfactory receptor 4D2 BAO_0201027 A protein that is a translation product of the human OR7D4 gene or a 1:1 ortholog thereof. [PRO:DNx] OR19-7 OR7D4 OR7D4 PRO:000011992 Q8NG98 Olfactory receptor 7D4 BAO_0201028 A protein that is a translation product of the human OR7G1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR19-15 OR7G1 OR7G1 PRO:000011993 Q8NGA0 Olfactory receptor 7G1 BAO_0201029 A protein that is a translation product of the human OR1M1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR19-5 OR1M1 OR1M1 PRO:000011737 Q8NGA1 Olfactory receptor 1M1 BAO_0201030 A protein that is a translation product of the human OR1I1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR19-20 OR1I1 OR1I1 O60431 PRO:000011727 Olfactory receptor 1I1 BAO_0201031 A protein that is a translation product of the human OR10H4 gene or a 1:1 ortholog thereof. [PRO:DNx] OR10H4 OR19-28 OR10H4 PRO:000011671 Q8NGA5 Olfactory receptor 10H4 BAO_0201032 A protein that is a translation product of the human OR2M5 gene or a 1:1 ortholog thereof. [PRO:DNx] OR2M5 OR2M5P OR2M5 A3KFT3 PRO:000011781 Olfactory receptor 2M5 BAO_0201033 A protein that is a translation product of the human OR2M3 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1-54 OR2M3 OR2M3 PRO:000011779 Q8NG83 Olfactory receptor 2M3 BAO_0201034 A protein that is a translation product of the human OR2T12 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1-57 OR2T12 OR2T12 PRO:000011787 Q8NG77 Olfactory receptor 2T12 BAO_0201035 A protein that is a translation product of the human OR14C36 gene or a 1:1 ortholog thereof. [PRO:DNx] OR14C36 OR5BF1 OR14C36 PRO:000011711 Q8NHC7 Olfactory receptor 14C36 BAO_0201036 A protein that is a translation product of the human OR2T10 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1-64 OR2T10 OR2T10 PRO:000011785 Q8NGZ9 Olfactory receptor 2T10 BAO_0201037 A protein that is a translation product of the human OR2T4 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1-60 OR2T4 OR2T4 PRO:000011795 Q8NH00 Olfactory receptor 2T4 BAO_0201038 A protein that is a translation product of the human OR2T11 gene or a 1:1 ortholog thereof. [PRO:DNx] OR2T11 OR2T11Q OR2T11 PRO:000011786 Q8NH01 Olfactory receptor 2T11 BAO_0201039 A protein that is a translation product of the human OR10J5 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1-28 OR10J5 OR10J5 PRO:000011675 Q8NHC4 Olfactory receptor 10J5 BAO_0201040 A protein that is a translation product of the human OR10T2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1-3 OR10T2 OR10T2 PRO:000011682 Q8NGX3 Olfactory receptor 10T2 BAO_0201041 A protein that is a translation product of the human OR10X1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1-13 OR10X1 OR10X1 PRO:000011685 Q8NGY0 Olfactory receptor 10X1 BAO_0201042 A protein that is a translation product of the human OR10Z1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1-15 OR10Z1 OR10Z1 PRO:000011686 Q8NGY1 Olfactory receptor 10Z1 BAO_0201043 A protein that is a translation product of the human OR6K6 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1-21 OR6K6 OR6K6 PRO:000011975 Q8NGW6 Olfactory receptor 6K6 BAO_0201044 A protein that is a translation product of the human OR6N1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1-22 OR6N1 OR6N1 PRO:000011977 Q8NGY5 Olfactory receptor 6N1 BAO_0201045 A protein that is a translation product of the human OR2Y1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR2Y1 OR5-2 OR2Y1 PRO:000011802 Q8NGV0 Olfactory receptor 2Y1 BAO_0201046 A protein that is a translation product of the human OR2A14 gene or a 1:1 ortholog thereof. [PRO:DNx] OR2A14 OR2A14P OR2A14 PRO:000011744 Q96R47 Olfactory receptor 2A14 BAO_0201047 A protein that is a translation product of the human OR6B1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR6B1 OR7-3 OR6B1 O95007 PRO:000011957 Olfactory receptor 6B1 BAO_0201048 A protein that is a translation product of the human OR2F2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR2F2 OR7-1 OR2F2 O95006 PRO:000011765 Olfactory receptor 2F2 BAO_0201049 A protein that is a translation product of the human OR13C5 gene or a 1:1 ortholog thereof. [PRO:DNx] OR13C5 OR9-11 OR13C5 PRO:000011701 Q8NGS8 Olfactory receptor 13C5 BAO_0201050 A protein that is a translation product of the human OR13C8 gene or a 1:1 ortholog thereof. [PRO:DNx] OR13C8 OR37H OR13C8 PRO:000011702 Q8NGS7 Olfactory receptor 13C8 BAO_0201051 A protein that is a translation product of the human OR13C3 gene or a 1:1 ortholog thereof. [PRO:DNx] OR13C3 OR37G OR13C3 PRO:000011699 Q8NGS6 Olfactory receptor 13C3 BAO_0201052 A protein that is a translation product of the human OR13C4 gene or a 1:1 ortholog thereof. [PRO:DNx] HSHTPCRX17 OR13C4 OR13C4 PRO:000011700 Q8NGS5 Olfactory receptor 13C4 BAO_0201053 A protein that is a translation product of the human OR13F1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR13F1 OR9-6 OR13F1 PRO:000011705 Q8NGS4 Olfactory receptor 13F1 BAO_0201054 A protein that is a translation product of the human OR1L8 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1L8 OR9-24 OR1L8 PRO:000011736 Q8NGR8 Olfactory receptor 1L8 BAO_0201055 A protein that is a translation product of the human OR1N2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1N2 OR9-23 OR1N2 PRO:000011739 Q8NGR9 Olfactory receptor 1N2 BAO_0201056 A protein that is a translation product of the human OR1N1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1-26 OR1N1 OR1N1 PRO:000011738 Q8NGS0 Olfactory receptor 1N1 BAO_0201057 A protein that is a translation product of the human OR52B4 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-3 OR52B4 OR52B4 PRO:000011883 Q8NGK2 Olfactory receptor 52B4 BAO_0201058 A protein that is a translation product of the human OR52I2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-12 OR52I2 OR52I2 PRO:000011892 Q8NH67 Olfactory receptor 52I2 BAO_0201059 A protein that is a translation product of the human OR51E1 gene or a 1:1 ortholog thereof. [PRO:DNx] D-GPCR OR51E1 OR51E1 PRO:000011865 Q8TCB6 Olfactory receptor 51E1 BAO_0201060 A protein that is a translation product of the human OR10A5 gene or a 1:1 ortholog thereof. [PRO:DNx] JCG6 OR10A5 OR10A5 PRO:000011656 Q9H207 Olfactory receptor 10A5 BAO_0201061 A protein that is a translation product of the human OR2AG1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-79 OR2AG1 OR2AG1 PRO:000011752 Q9H205 Olfactory receptor 2AG1 BAO_0201062 A protein that is a translation product of the human OR6B3 gene or a 1:1 ortholog thereof. [PRO:DNx] OR6B3 OR6B3P OR6B3 PRO:000011959 Q8NGW1 Olfactory receptor 6B3 BAO_0201063 A protein that is a translation product of the human OR1Q1 gene or a 1:1 ortholog thereof. [PRO:DNx] HSTPCR106 OR1Q1 OR1Q1 PRO:000011741 Q15612 Olfactory receptor 1Q1 BAO_0201064 A protein that is a translation product of the human OR7D2 gene or a 1:1 ortholog thereof. [PRO:DNx] FLJ38149 OR7D2 OR7D2 PRO:000011991 Q96RA2 Olfactory receptor 7D2 BAO_0201065 A protein that is a translation product of the human OR56B4 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-67 OR56B4 OR56B4 PRO:000011908 Q8NH76 Olfactory receptor 56B4 BAO_0201066 A protein that is a translation product of the human OR4C16 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-135 OR4C16 OR4C16 PRO:000011817 Q8NGL9 Olfactory receptor 4C16 BAO_0201067 A protein that is a translation product of the human OR4C11 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-136 OR4C11 OR4C11 PRO:000011813 Q6IEV9 Olfactory receptor 4C11 BAO_0201068 A protein that is a translation product of the human OR4S2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-137 OR4S2 OR4S2 PRO:000011854 Q8NH73 Olfactory receptor 4S2 BAO_0201069 A protein that is a translation product of the human OR4C6 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-138 OR4C6 OR4C6 PRO:000011822 Q8NH72 Olfactory receptor 4C6 BAO_0201070 A protein that is a translation product of the human OR5D14 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-141 OR5D14 OR5D14 PRO:000011925 Q8NGL3 Olfactory receptor 5D14 BAO_0201071 A protein that is a translation product of the human OR5L1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-151 OR5L1 OR5L1 PRO:000011940 Q8NGL2 Olfactory receptor 5L1 BAO_0201072 A protein that is a translation product of the human OR5D18 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-143 OR5D18 OR5D18 PRO:000011927 Q8NGL1 Olfactory receptor 5D18 BAO_0201073 A protein that is a translation product of the human OR5AS1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-168 OR5AS1 OR5AS1 PRO:000011916 Q8N127 Olfactory receptor 5AS1 BAO_0201074 A protein that is a translation product of the human OR8K5 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-174 OR8K5 OR8K5 PRO:000012015 Q8NH50 Olfactory receptor 8K5 BAO_0201075 A protein that is a translation product of the human OR5T2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-177 OR5T2 OR5T2 PRO:000011952 Q8NGG2 Olfactory receptor 5T2 BAO_0201076 A protein that is a translation product of the human OR8H1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-180 OR8H1 OR8H1 PRO:000012007 Q8NGG4 Olfactory receptor 8H1 BAO_0201077 A protein that is a translation product of the human OR8K3 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-181 OR8K3 OR8K3 PRO:000012014 Q8NH51 Olfactory receptor 8K3 BAO_0201078 A protein that is a translation product of the human OR8J1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-183 OR8J1 OR8J1 PRO:000012011 Q8NGP2 Olfactory receptor 8J1 BAO_0201079 A protein that is a translation product of the human OR5R1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-185 OR5R1 OR5R1 PRO:000011950 Q8NH85 Olfactory receptor 5R1 BAO_0201080 A protein that is a translation product of the human OR5M3 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-191 OR5M3 OR5M3 PRO:000011945 Q8NGP4 Olfactory receptor 5M3 BAO_0201081 A protein that is a translation product of the human OR5M8 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-194 OR5M8 OR5M8 PRO:000011946 Q8NGP6 Olfactory receptor 5M8 BAO_0201082 A protein that is a translation product of the human OR5M11 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-199 OR5M11 OR5M11 PRO:000011944 Q96RB7 Olfactory receptor 5M11 BAO_0201083 A protein that is a translation product of the human OR5AR1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-209 OR5AR1 OR5AR1 PRO:000011915 Q8NGP9 Olfactory receptor 5AR1 BAO_0201084 A protein that is a translation product of the human OR8B12 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-317 OR8B12 OR8B12 PRO:000011997 Q8NGG6 Olfactory receptor 8B12 BAO_0201085 A protein that is a translation product of the human OR8G5 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-298 OR8G5 OR8G5 PRO:000031803 Q8NG78 Olfactory receptor 8G5 BAO_0201086 A protein that is a translation product of the human OR10G8 gene or a 1:1 ortholog thereof. [PRO:DNx] OR10G8 OR11-274 OR10G8 PRO:000011666 Q8NGN5 Olfactory receptor 10G8 BAO_0201087 A protein that is a translation product of the human OR10G9 gene or a 1:1 ortholog thereof. [PRO:DNx] OR10G10P OR10G9 OR10G9 PRO:000011667 Q8NGN4 Olfactory receptor 10G9 BAO_0201088 A protein that is a translation product of the human OR10S1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR10S1 OR11-279 OR10S1 PRO:000011681 Q8NGN2 Olfactory receptor 10S1 BAO_0201089 A protein that is a translation product of the human OR6T1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-277 OR6T1 OR6T1 PRO:000011982 Q8NGN1 Olfactory receptor 6T1 BAO_0201090 A protein that is a translation product of the human OR4D5 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-276 OR4D5 OR4D5 PRO:000011827 Q8NGN0 Olfactory receptor 4D5 BAO_0201091 A protein that is a translation product of the human OR6Q1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-226 OR6Q1 OR6Q1 PRO:000011980 Q8NGQ2 Olfactory receptor 6Q1 BAO_0201092 A protein that is a translation product of the human OR9I1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-228 OR9I1 OR9I1 PRO:000012023 Q8NGQ6 Olfactory receptor 9I1 BAO_0201093 A protein that is a translation product of the human OR9Q1 gene or a 1:1 ortholog thereof. [PRO:DNx] MGC131737 OR9Q1 OR9Q1 PRO:000012025 Q8NGQ5 Olfactory receptor 9Q1 BAO_0201094 A protein that is a translation product of the human OR9Q2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR9Q2 OR9Q2P OR9Q2 PRO:000012026 Q8NGE9 Olfactory receptor 9Q2 BAO_0201095 A protein that is a translation product of the human OR1S2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-231 OR1S2 OR1S2 PRO:000011743 Q8NGQ3 Olfactory receptor 1S2 BAO_0201096 A protein that is a translation product of the human OR1S1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-232 OR1S1 OR1S1 PRO:000011742 Q8NH92 Olfactory receptor 1S1 BAO_0201097 A protein that is a translation product of the human OR10Q1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR10Q1 OR11-233 OR10Q1 PRO:000011679 Q8NGQ4 Olfactory receptor 10Q1 BAO_0201098 A protein that is a translation product of the human OR5B17 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-237 OR5B17 OR5B17 PRO:000011919 Q8NGF7 Olfactory receptor 5B17 BAO_0201099 A protein that is a translation product of the human OR5A1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-249 OR5A1 OR5A1 PRO:000011909 Q8NGJ0 Olfactory receptor 5A1 BAO_0201100 A protein that is a translation product of the human OR4D6 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-250 OR4D6 OR4D6 PRO:000011828 Q8NGJ1 Olfactory receptor 4D6 BAO_0201101 A protein that is a translation product of the human OR4D11 gene or a 1:1 ortholog thereof. [PRO:DNx] OR4D11 OR4D11P OR4D11 PRO:000011825 Q8NGI4 Olfactory receptor 4D11 BAO_0201102 A protein that is a translation product of the human OR52A1 gene or a 1:1 ortholog thereof. [PRO:DNx] HPFH1OR OR52A1 OR52A1 PRO:000011880 Q9UKL2 Olfactory receptor 52A1 BAO_0201103 A protein that is a translation product of the human OR6C3 gene or a 1:1 ortholog thereof. [PRO:DNx] OR6C3 OST709 OR6C3 PRO:000011962 Q9NZP0 Olfactory receptor 6C3 BAO_0201104 A protein that is a translation product of the human OR2T6 gene or a 1:1 ortholog thereof. [PRO:DNx] OR2T6 OR2T6P OR2T6 PRO:000011797 Q8NHC8 Olfactory receptor 2T6 BAO_0201105 A protein that is a translation product of the human OR1L4 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1L4 OR1L5 OR1L4 PRO:000011734 Q8NGR5 Olfactory receptor 1L4 BAO_0201106 A protein that is a translation product of the human OR52B2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-70 OR52B2 OR52B2 PRO:000011882 Q96RD2 Olfactory receptor 52B2 BAO_0201107 A protein that is a translation product of the human OR4C3 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-98 OR4C3 OR4C3 PRO:000011818 Q8NH37 Olfactory receptor 4C3 BAO_0201108 A protein that is a translation product of the human OR4S1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-100 OR4S1 OR4S1 PRO:000011853 Q8NGB4 Olfactory receptor 4S1 BAO_0201109 A protein that is a translation product of the human OR1C1 gene or a 1:1 ortholog thereof. [PRO:DNx] HSTPCR27 OR1C1 OR1C1 PRO:000011718 Q15619 Olfactory receptor 1C1 BAO_0201110 A protein that is a translation product of the human OR1A2 gene or a 1:1 ortholog thereof. [PRO:DNx] MGC119930 OR1A2 OR1A2 PRO:000011716 Q9Y585 Olfactory receptor 1A2 BAO_0201111 A protein that is a translation product of the human OR2F1 gene or a 1:1 ortholog thereof. [PRO:DNx] OLF3 OR2F1 OR2F1 PRO:000011764 Q13607 Olfactory receptor 2F1 BAO_0201112 A protein that is a translation product of the human OR2B6 gene or a 1:1 ortholog thereof. [PRO:DNx] MGC120190 OR2B6 OR2B6 P58173 PRO:000011759 Olfactory receptor 2B6 BAO_0201113 A protein that is a translation product of the human OR1J4 gene or a 1:1 ortholog thereof. [PRO:DNx] HSHTPCRX01 OR1J4 OR1J4 PRO:000011730 Q8NGS1 Olfactory receptor 1J4 BAO_0201114 A protein that is a translation product of the human OR2M4 gene or a 1:1 ortholog thereof. [PRO:DNx] HSHTPCRX18 OR2M4 OR2M4 PRO:000011780 Q96R27 Olfactory receptor 2M4 BAO_0201115 A protein that is a translation product of the human OR2L2 gene or a 1:1 ortholog thereof. [PRO:DNx] HSHTPCRH07 OR2L2 OR2L2 PRO:000011775 Q8NH16 Olfactory receptor 2L2 BAO_0201116 A protein that is a translation product of the human OR2K2 gene or a 1:1 ortholog thereof. [PRO:DNx] HSHTPCRH06 OR2K2 OR2K2 PRO:000011773 Q8NGT1 Olfactory receptor 2K2 BAO_0201117 A protein that is a translation product of the human OR7A17 gene or a 1:1 ortholog thereof. [PRO:DNx] BC85395_4 OR7A17 OR7A17 O14581 PRO:000011987 Olfactory receptor 7A17 BAO_0201118 A protein that is a translation product of the human OR5L2 gene or a 1:1 ortholog thereof. [PRO:DNx] HSHTPCRX16 OR5L2 OR5L2 PRO:000011941 Q8NGL0 Olfactory receptor 5L2 BAO_0201119 A protein that is a translation product of the human OR5K1 gene or a 1:1 ortholog thereof. [PRO:DNx] HSHTPCRX10 OR5K1 OR5K1 PRO:000011936 Q8NHB7 Olfactory receptor 5K1 BAO_0201120 A protein that is a translation product of the human OR5H1 gene or a 1:1 ortholog thereof. [PRO:DNx] HSHTPCRX14 OR5H1 OR5H1 A6NKK0 PRO:000011929 Olfactory receptor 5H1 BAO_0201121 A protein that is a translation product of the human OR10J1 gene or a 1:1 ortholog thereof. [PRO:DNx] HGMP07J OR10J1 OR10J1 P30954 PRO:000011673 Olfactory receptor 10J1 BAO_0201122 A protein that is a translation product of the human OR8B8 gene or a 1:1 ortholog thereof. [PRO:DNx] OR8B8 TPCR85 OR8B8 PRO:000012001 Q15620 Olfactory receptor 8B8 BAO_0201123 A protein that is a translation product of the human OR8G1 gene or a 1:1 ortholog thereof. [PRO:DNx] HSTPCR25 OR8G1 OR8G1 PRO:000012005 Q15617 Olfactory receptor 8G1 BAO_0201124 A protein that is a translation product of the human OR10A3 gene or a 1:1 ortholog thereof. [PRO:DNx] HSHTPCRX12 OR10A3 OR10A3 P58181 PRO:000011654 Olfactory receptor 10A3 BAO_0201125 A protein that is a translation product of the human OR12D2 gene or a 1:1 ortholog thereof. [PRO:DNx] DJ994E9.8 OR12D2 OR12D2 P58182 PRO:000011695 Olfactory receptor 12D2 BAO_0201126 A protein that is a translation product of the human OR11A1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11A1 OR11A2 OR11A1 PRO:000011687 Q9GZK7 Olfactory receptor 11A1 BAO_0201127 A protein that is a translation product of the human OR10H3 gene or a 1:1 ortholog thereof. [PRO:DNx] MGC119147 OR10H3 OR10H3 O60404 PRO:000011670 Olfactory receptor 10H3 BAO_0201128 A protein that is a translation product of the human OR10G3 gene or a 1:1 ortholog thereof. [PRO:DNx] OR10G3 OR14-40 OR10G3 PRO:000011662 Q8NGC4 Olfactory receptor 10G3 BAO_0201129 A protein that is a translation product of the human OR10G2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR10G2 OR14-41 OR10G2 PRO:000011661 Q8NGC3 Olfactory receptor 10G2 BAO_0201130 A protein that is a translation product of the human OR10H2 gene or a 1:1 ortholog thereof. [PRO:DNx] MGC138383 OR10H2 OR10H2 O60403 PRO:000011669 Olfactory receptor 10H2 BAO_0201131 A protein that is a translation product of the human OR8B2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-309 OR8B2 OR8B2 PRO:000011998 Q96RD0 Olfactory receptor 8B2 BAO_0201132 A protein that is a translation product of the human OR7E24 gene or a 1:1 ortholog thereof. [PRO:DNx] HSHT2 OR7E24 OR7E24 PRO:000030348 Q6IFN5 Olfactory receptor 7E24 BAO_0201133 A protein that is a translation product of the human OR7C2 gene or a 1:1 ortholog thereof. [PRO:DNx] CIT-HSP-87M17 OR7C2 OR7C2 O60412 PRO:000011990 Olfactory receptor 7C2 BAO_0201134 A protein that is a translation product of the human OR7A5 gene or a 1:1 ortholog thereof. [PRO:DNx] HTPCR2 OR7A5 OR7A5 PRO:000011988 Q15622 Olfactory receptor 7A5 BAO_0201135 A protein that is a translation product of the human OR7C1 gene or a 1:1 ortholog thereof. [PRO:DNx] CIT-HSP-146E8 OR7C1 OR7C1 O76099 PRO:000011989 Olfactory receptor 7C1 BAO_0201136 A protein that is a translation product of the human OR4F4 gene or a 1:1 ortholog thereof. [PRO:DNx] OLA-7501 OR4F4 OR4F4 PRO:000011835 Q96R69 Olfactory receptor 4F4 BAO_0201137 A protein that is a translation product of the human OR4E2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR14-42 OR4E2 OR4E2 PRO:000011830 Q8NGC2 Olfactory receptor 4E2 BAO_0201138 A protein that is a translation product of the human OR4D1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR17-23 OR4D1 OR4D1 PRO:000011823 Q15615 Olfactory receptor 4D1 BAO_0201139 A protein that is a translation product of the human OR2W1 gene or a 1:1 ortholog thereof. [PRO:DNx] MGC119162 OR2W1 OR2W1 PRO:000011800 Q9Y3N9 Olfactory receptor 2W1 BAO_0201140 A protein that is a translation product of the human OR2V1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR2V1 OR2V1P OR2V1 PRO:000031641 Q8NHB1 Olfactory receptor 2V1 BAO_0201141 A protein that is a translation product of the human OR2T1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1-25 OR2T1 OR2T1 O43869 PRO:000011784 Olfactory receptor 2T1 BAO_0201142 A protein that is a translation product of the human OR2J2 gene or a 1:1 ortholog thereof. [PRO:DNx] MGC119134 OR2J2 OR2J2 O76002 PRO:000011771 Olfactory receptor 2J2 BAO_0201143 A protein that is a translation product of the human OR2H1 gene or a 1:1 ortholog thereof. [PRO:DNx] 6M1-16 OR2H1 OR2H1 PRO:000011769 Q9GZK4 Olfactory receptor 2H1 BAO_0201144 A protein that is a translation product of the human OR1L3 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1L3 OR9-28 OR1L3 PRO:000011733 Q8NH93 Olfactory receptor 1L3 BAO_0201145 A protein that is a translation product of the human OR1L1 gene or a 1:1 ortholog thereof. [PRO:DNx] HG23 OR1L1 OR1L1 PRO:000011732 Q8NH94 Olfactory receptor 1L1 BAO_0201146 A protein that is a translation product of the human OR1J2 gene or a 1:1 ortholog thereof. [PRO:DNx] FLJ16828 OR1J2 OR1J2 PRO:000011729 Q8NGS2 Olfactory receptor 1J2 BAO_0201147 A protein that is a translation product of the human OR51B5 gene or a 1:1 ortholog thereof. [PRO:DNx] HOR5'Beta5 OR51B5 OR51B5 PRO:000011862 Q9H339 Olfactory receptor 51B5 BAO_0201148 A protein that is a translation product of the human OR10AG1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR10AG1 OR11-160 OR10AG1 PRO:000011659 Q8NH19 Olfactory receptor 10AG1 BAO_0201149 A protein that is a translation product of the human OR5J2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-266 OR5J2 OR5J2 PRO:000011935 Q8NH18 Olfactory receptor 5J2 BAO_0201150 A protein that is a translation product of the human OR4C12 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-259 OR4C12 OR4C12 PRO:000011814 Q96R67 Olfactory receptor 4C12 BAO_0201151 A protein that is a translation product of the human OR51V1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-36 OR51V1 OR51V1 PRO:000011879 Q9H2C8 Olfactory receptor 51V1 BAO_0201152 A protein that is a translation product of the human OR8D1 gene or a 1:1 ortholog thereof. [PRO:DNx] JCG9 OR8D1 OR8D1 PRO:000012002 Q8WZ84 Olfactory receptor 8D1 BAO_0201153 A protein that is a translation product of the human OR8D2 gene or a 1:1 ortholog thereof. [PRO:DNx] JCG2 OR8D2 OR8D2 PRO:000012003 Q9GZM6 Olfactory receptor 8D2 BAO_0201154 A protein that is a translation product of the human OR8B4 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-315 OR8B4 OR8B4 PRO:000012000 Q96RC9 Olfactory receptor 8B4 BAO_0201155 A protein that is a translation product of the human OR9G4 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-216 OR9G4 OR9G4 PRO:000012022 Q8NGQ1 Olfactory receptor 9G4 BAO_0201156 A protein that is a translation product of the human OR10A4 gene or a 1:1 ortholog thereof. [PRO:DNx] JCG5 OR10A4 OR10A4 PRO:000011655 Q9H209 Olfactory receptor 10A4 BAO_0201157 A protein that is a translation product of the human OR4N4 gene or a 1:1 ortholog thereof. [PRO:DNx] OR15-1 OR4N4 OR4N4 PRO:000011849 Q8N0Y3 Olfactory receptor 4N4 BAO_0201158 A protein that is a translation product of the human OR2Z1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR19-4 OR2Z1 OR2Z1 PRO:000011803 Q8NG97 Olfactory receptor 2Z1 BAO_0201159 A protein that is a translation product of the human OR10H5 gene or a 1:1 ortholog thereof. [PRO:DNx] OR10H5 OR19-25 OR10H5 PRO:000011672 Q8NGA6 Olfactory receptor 10H5 BAO_0201160 A protein that is a translation product of the human OR2L13 gene or a 1:1 ortholog thereof. [PRO:DNx] MGC40047 OR2L13 OR2L13 PRO:000011774 Q8N349 Olfactory receptor 2L13 BAO_0201161 A protein that is a translation product of the human OR14A16 gene or a 1:1 ortholog thereof. [PRO:DNx] OR14A16 OR5AT1 OR14A16 PRO:000011709 Q8NHC5 Olfactory receptor 14A16 BAO_0201162 A protein that is a translation product of the human OR2V2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR2V2 OR2V3 OR2V2 PRO:000011799 Q96R30 Olfactory receptor 2V2 BAO_0201163 A protein that is a translation product of the human OR13C9 gene or a 1:1 ortholog thereof. [PRO:DNx] OR13C9 OR37L OR13C9 PRO:000011703 Q8NGT0 Olfactory receptor 13C9 BAO_0201164 A protein that is a translation product of the human OR13D1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR13D1 OR9-15 OR13D1 PRO:000011704 Q8NGV5 Olfactory receptor 13D1 BAO_0201165 A protein that is a translation product of the human OR8D4 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-275 OR8D4 OR8D4 PRO:000012004 Q8NGM9 Olfactory receptor 8D4 BAO_0201166 A protein that is a translation product of the human OR5F1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-10 OR5F1 OR5F1 O95221 PRO:000011928 Olfactory receptor 5F1 BAO_0201167 A protein that is a translation product of the human OR5AP2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR5AP2 OR9J1 OR5AP2 PRO:000011914 Q8NGF4 Olfactory receptor 5AP2 BAO_0201168 A protein that is a translation product of the human OR52L1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-50 OR52L1 OR52L1 PRO:000011896 Q8NGH7 Olfactory receptor 52L1 BAO_0201169 A protein that is a translation product of the human OR2AG2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-76 OR2AG2 OR2AG2 A6NM03 PRO:000011753 Olfactory receptor 2AG2 BAO_0201170 A protein that is a translation product of the human OR52B6 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-47 OR52B6 OR52B6 PRO:000011884 Q8NGF0 Olfactory receptor 52B6 BAO_0201171 A protein that is a translation product of the human OR2AT4 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-265 OR2AT4 OR2AT4 A6NND4 PRO:000011756 Olfactory receptor 2AT4 BAO_0201172 A protein that is a translation product of the human OR10A2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR10A2 OR10A2P OR10A2 PRO:000011653 Q9H208 Olfactory receptor 10A2 BAO_0201173 A protein that is a translation product of the human OR6C2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR6C2 OR6C67 OR6C2 PRO:000011961 Q9NZP2 Olfactory receptor 6C2 BAO_0201174 A protein that is a translation product of the human OR6C4 gene or a 1:1 ortholog thereof. [PRO:DNx] OR12-10 OR6C4 OR6C4 PRO:000011963 Q8NGE1 Olfactory receptor 6C4 BAO_0201175 A protein that is a translation product of the human OR6S1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR14-37 OR6S1 OR6S1 PRO:000011981 Q8NH40 Olfactory receptor 6S1 BAO_0201176 A protein that is a translation product of the human OR6F1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1-34 OR6F1 OR6F1 PRO:000011971 Q8NGZ6 Olfactory receptor 6F1 BAO_0201177 A protein that is a translation product of the human OR2W3 gene or a 1:1 ortholog thereof. [PRO:DNx] OR2W3 OR2W3P OR2W3 PRO:000011801 Q7Z3T1 Olfactory receptor 2W3 BAO_0201178 A protein that is a translation product of the human OR2T8 gene or a 1:1 ortholog thereof. [PRO:DNx] OR2T8 OR2T8P OR2T8 A6NH00 PRO:000011798 Olfactory receptor 2T8 BAO_0201179 A protein that is a translation product of the human OR10R2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1-8 OR10R2 OR10R2 PRO:000011680 Q8NGX6 Olfactory receptor 10R2 BAO_0201180 A protein that is a translation product of the human OR6V1 gene or a 1:1 ortholog thereof. [PRO:DNx] GPR138 OR6V1 OR6V1 PRO:000011983 Q8N148 Olfactory receptor 6V1 BAO_0201181 A protein that is a translation product of the human OR2A12 gene or a 1:1 ortholog thereof. [PRO:DNx] OR2A12 OR2A12P OR2A12 PRO:000031460 Q8NGT7 Olfactory receptor 2A12 BAO_0201182 A protein that is a translation product of the human OR1J1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1J1 OR9-18 OR1J1 PRO:000011728 Q8NGS3 Olfactory receptor 1J1 BAO_0201183 A protein that is a translation product of the human OR1B1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1B1 OR9-26 OR1B1 PRO:000011717 Q8NGR6 Olfactory receptor 1B1 BAO_0201184 A protein that is a translation product of the human OR13H1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR13H1 ORX1 OR13H1 PRO:000011707 Q8NG92 Olfactory receptor 13H1 BAO_0201185 A protein that is a translation product of the human OR56B1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-65 OR56B1 OR56B1 PRO:000011907 Q8NGI3 Olfactory receptor 56B1 BAO_0201186 A protein that is a translation product of the human OR6B2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR2-1 OR6B2 OR6B2 PRO:000011958 Q6IFH4 Olfactory receptor 6B2 BAO_0201187 A protein that is a translation product of the human OR52K1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-8 OR52K1 OR52K1 PRO:000011894 Q8NGK4 Olfactory receptor 52K1 BAO_0201188 A protein that is a translation product of the human OR52I1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-13 OR52I1 OR52I1 PRO:000011891 Q8NGK6 Olfactory receptor 52I1 BAO_0201189 A protein that is a translation product of the human OR51D1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-14 OR51D1 OR51D1 PRO:000011864 Q8NGF3 Olfactory receptor 51D1 BAO_0201190 A protein that is a translation product of the human OR52A5 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-33 OR52A5 OR52A5 PRO:000011881 Q9H2C5 Olfactory receptor 52A5 BAO_0201191 A protein that is a translation product of the human OR51B6 gene or a 1:1 ortholog thereof. [PRO:DNx] HOR5'Beta6 OR51B6 OR51B6 PRO:000011863 Q9H340 Olfactory receptor 51B6 BAO_0201192 A protein that is a translation product of the human OR51I2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-38 OR51I2 OR51I2 PRO:000011872 Q9H344 Olfactory receptor 51I2 BAO_0201193 A protein that is a translation product of the human OR52D1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-43 OR52D1 OR52D1 PRO:000011885 Q9H346 Olfactory receptor 52D1 BAO_0201194 A protein that is a translation product of the human OR52H1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-41 OR52H1 OR52H1 PRO:000011890 Q8NGJ2 Olfactory receptor 52H1 BAO_0201195 A protein that is a translation product of the human OR52N4 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-64 OR52N4 OR52N4 PRO:000011900 Q8NGI2 Olfactory receptor 52N4 BAO_0201196 A protein that is a translation product of the human OR52N5 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-62 OR52N5 OR52N5 PRO:000011901 Q8NH56 Olfactory receptor 52N5 BAO_0201197 A protein that is a translation product of the human OR52N2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-57 OR52N2 OR52N2 PRO:000011899 Q8NGI0 Olfactory receptor 52N2 BAO_0201198 A protein that is a translation product of the human OR52E6 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-58 OR52E6 OR52E6 PRO:000011888 Q96RD3 Olfactory receptor 52E6 BAO_0201199 A protein that is a translation product of the human OR52E8 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-54 OR52E8 OR52E8 PRO:000011889 Q6IFG1 Olfactory receptor 52E8 BAO_0201200 A protein that is a translation product of the human OR52E4 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-55 OR52E4 OR52E4 PRO:000011887 Q8NGH9 Olfactory receptor 52E4 BAO_0201201 A protein that is a translation product of the human OR56A3 gene or a 1:1 ortholog thereof. [PRO:DNx] OR56A2P OR56A3 OR56A3 PRO:000011905 Q8NH54 Olfactory receptor 56A3 BAO_0201202 A protein that is a translation product of the human OR56A5 gene or a 1:1 ortholog thereof. [PRO:DNx] OR56A5 OR56A5P OR56A5 P0C7T3 PRO:000030998 Olfactory receptor 56A5 BAO_0201203 A protein that is a translation product of the human OR10A6 gene or a 1:1 ortholog thereof. [PRO:DNx] OR10A6 OR11-96 OR10A6 PRO:000011657 Q8NH74 Olfactory receptor 10A6 BAO_0201204 A protein that is a translation product of the human OR4X1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-104 OR4X1 OR4X1 PRO:000011855 Q8NH49 Olfactory receptor 4X1 BAO_0201205 A protein that is a translation product of the human OR5D16 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-154 OR5D16 OR5D16 PRO:000011926 Q8NGK9 Olfactory receptor 5D16 BAO_0201206 A protein that is a translation product of the human OR5W2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR5W2 OR5W2P OR5W2 PRO:000011955 Q8NH69 Olfactory receptor 5W2 BAO_0201207 A protein that is a translation product of the human OR8H2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-171 OR8H2 OR8H2 PRO:000012008 Q8N162 Olfactory receptor 8H2 BAO_0201208 A protein that is a translation product of the human OR8H3 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-172 OR8H3 OR8H3 PRO:000012009 Q8N146 Olfactory receptor 8H3 BAO_0201209 A protein that is a translation product of the human OR5T3 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-178 OR5T3 OR5T3 PRO:000011953 Q8NGG3 Olfactory receptor 5T3 BAO_0201210 A protein that is a translation product of the human OR5T1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-179 OR5T1 OR5T1 PRO:000011951 Q8NG75 Olfactory receptor 5T1 BAO_0201211 A protein that is a translation product of the human OR8K1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-182 OR8K1 OR8K1 PRO:000012013 Q8NGG5 Olfactory receptor 8K1 BAO_0201212 A protein that is a translation product of the human OR5M9 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-190 OR5M9 OR5M9 PRO:000011947 Q8NGP3 Olfactory receptor 5M9 BAO_0201213 A protein that is a translation product of the human OR5M10 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-207 OR5M10 OR5M10 PRO:000011943 Q6IEU7 Olfactory receptor 5M10 BAO_0201214 A protein that is a translation product of the human OR5M1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-208 OR5M1 OR5M1 PRO:000011942 Q8NGP8 Olfactory receptor 5M1 BAO_0201215 A protein that is a translation product of the human OR9G1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR9G1 OR9G5 OR9G1 PRO:000012021 Q8NH87 Olfactory receptor 9G1 BAO_0201216 A protein that is a translation product of the human OR5B2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-240 OR5B2 OR5B2 PRO:000011920 Q96R09 Olfactory receptor 5B2 BAO_0201217 A protein that is a translation product of the human OR5B12 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-241 OR5B12 OR5B12 PRO:000011918 Q96R08 Olfactory receptor 5B12 BAO_0201218 A protein that is a translation product of the human OR5AN1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-244 OR5AN1 OR5AN1 PRO:000011913 Q8NGI8 Olfactory receptor 5AN1 BAO_0201219 A protein that is a translation product of the human OR4D10 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-251 OR4D10 OR4D10 PRO:000011824 Q8NGI6 Olfactory receptor 4D10 BAO_0201220 A protein that is a translation product of the human OR4D9 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-253 OR4D9 OR4D9 PRO:000011829 Q8NGE8 Olfactory receptor 4D9 BAO_0201221 A protein that is a translation product of the human OR10V1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR10V1 OR11-256 OR10V1 PRO:000011683 Q8NGI7 Olfactory receptor 10V1 BAO_0201222 A protein that is a translation product of the human OR6X1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-270 OR6X1 OR6X1 PRO:000011984 Q8NH79 Olfactory receptor 6X1 BAO_0201223 A protein that is a translation product of the human OR6M1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-271 OR6M1 OR6M1 PRO:000011976 Q8NGM8 Olfactory receptor 6M1 BAO_0201224 A protein that is a translation product of the human OR10G4 gene or a 1:1 ortholog thereof. [PRO:DNx] OR10G4 OR11-278 OR10G4 PRO:000011663 Q8NGN3 Olfactory receptor 10G4 BAO_0201225 A protein that is a translation product of the human OR10G7 gene or a 1:1 ortholog thereof. [PRO:DNx] OR10G7 OR11-283 OR10G7 PRO:000011665 Q8NGN6 Olfactory receptor 10G7 BAO_0201226 A protein that is a translation product of the human OR8B3 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-311 OR8B3 OR8B3 PRO:000011999 Q8NGG8 Olfactory receptor 8B3 BAO_0201227 A protein that is a translation product of the human OR8A1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-318 OR8A1 OR8A1 PRO:000011996 Q8NGG7 Olfactory receptor 8A1 BAO_0201228 A protein that is a translation product of the human OR6C1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR6C1 OST267 OR6C1 PRO:000011960 Q96RD1 Olfactory receptor 6C1 BAO_0201229 A protein that is a translation product of the human OR4N2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR14-13 OR4N2 OR4N2 PRO:000011848 Q8NGD1 Olfactory receptor 4N2 BAO_0201230 A protein that is a translation product of the human OR4K2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR14-15 OR4K2 OR4K2 PRO:000011843 Q8NGD2 Olfactory receptor 4K2 BAO_0201231 A protein that is a translation product of the human OR4K13 gene or a 1:1 ortholog thereof. [PRO:DNx] OR14-27 OR4K13 OR4K13 PRO:000011839 Q8NH42 Olfactory receptor 4K13 BAO_0201232 A protein that is a translation product of the human OR4K17 gene or a 1:1 ortholog thereof. [PRO:DNx] OR14-29 OR4K17 OR4K17 PRO:000011842 Q8NGC6 Olfactory receptor 4K17 BAO_0201233 A protein that is a translation product of the human OR11G2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11G2 OR14-34 OR11G2 PRO:000011688 Q8NGC1 Olfactory receptor 11G2 BAO_0201234 A protein that is a translation product of the human OR11H4 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11H4 OR14-36 OR11H4 PRO:000011691 Q8NGC9 Olfactory receptor 11H4 BAO_0201235 A protein that is a translation product of the human OR5AU1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR14-38 OR5AU1 OR5AU1 PRO:000011917 Q8NGC0 Olfactory receptor 5AU1 BAO_0201236 A protein that is a translation product of the human OR4M2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR15-3 OR4M2 OR4M2 PRO:000011847 Q8NGB6 Olfactory receptor 4M2 BAO_0201237 A protein that is a translation product of the human OR4F6 gene or a 1:1 ortholog thereof. [PRO:DNx] OR15-15 OR4F6 OR4F6 PRO:000011837 Q8NGB9 Olfactory receptor 4F6 BAO_0201238 A protein that is a translation product of the human OR7G2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR19-6 OR7G2 OR7G2 PRO:000011994 Q8NG99 Olfactory receptor 7G2 BAO_0201239 A protein that is a translation product of the human OR7G3 gene or a 1:1 ortholog thereof. [PRO:DNx] OR7G3 OST085 OR7G3 PRO:000011995 Q8NG95 Olfactory receptor 7G3 BAO_0201240 A protein that is a translation product of the human OR7A10 gene or a 1:1 ortholog thereof. [PRO:DNx] BC85395_3 OR7A10 OR7A10 O76100 PRO:000011986 Olfactory receptor 7A10 BAO_0201241 A protein that is a translation product of the human OR10K2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1-4 OR10K2 OR10K2 PRO:000011677 Q6IF99 Olfactory receptor 10K2 BAO_0201242 A protein that is a translation product of the human OR10K1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1-6 OR10K1 OR10K1 PRO:000011676 Q8NGX5 Olfactory receptor 10K1 BAO_0201243 A protein that is a translation product of the human OR6Y1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1-11 OR6Y1 OR6Y1 PRO:000011985 Q8NGX8 Olfactory receptor 6Y1 BAO_0201244 A protein that is a translation product of the human OR6K3 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1-18 OR6K3 OR6K3 PRO:000011974 Q8NGY3 Olfactory receptor 6K3 BAO_0201245 A protein that is a translation product of the human OR2AK2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1-47 OR2AK2 OR2AK2 PRO:000011754 Q8NG84 Olfactory receptor 2AK2 BAO_0201246 A protein that is a translation product of the human OR2M2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR2M2 OR2M2Q OR2M2 PRO:000011778 Q96R28 Olfactory receptor 2M2 BAO_0201247 A protein that is a translation product of the human OR2T33 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1-56 OR2T33 OR2T33 PRO:000011792 Q8NG76 Olfactory receptor 2T33 BAO_0201248 A protein that is a translation product of the human OR2M7 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1-58 OR2M7 OR2M7 PRO:000011782 Q8NG81 Olfactory receptor 2M7 BAO_0201249 A protein that is a translation product of the human OR2A25 gene or a 1:1 ortholog thereof. [PRO:DNx] OR2A24P OR2A25 OR2A25 A4D2G3 PRO:000011746 Olfactory receptor 2A25 BAO_0201250 A protein that is a translation product of the human OR13J1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR13J1 OR9-2 OR13J1 PRO:000011708 Q8NGT2 Olfactory receptor 13J1 BAO_0201251 A protein that is a translation product of the human OR13C2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR13C2 OR37K OR13C2 PRO:000011698 Q8NGS9 Olfactory receptor 13C2 BAO_0201252 A protein that is a translation product of the human OR1L6 gene or a 1:1 ortholog thereof. [PRO:DNx] HG16 OR1L6 OR1L6 PRO:000011735 Q8NGR2 Olfactory receptor 1L6 BAO_0201253 A protein that is a translation product of the human OR5C1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR5C1 OR5C2P OR5C1 PRO:000011923 Q8NGR4 Olfactory receptor 5C1 BAO_0201254 A protein that is a translation product of the human OR1K1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1K1 hg99 OR1K1 PRO:000011731 Q8NGR3 Olfactory receptor 1K1 BAO_0201255 A protein that is a translation product of the human OR2A5 gene or a 1:1 ortholog thereof. [PRO:DNx] OR2A11P OR2A5 OR2A5 PRO:000011749 Q96R48 Olfactory receptor 2A5 BAO_0201256 A protein that is a translation product of the human OR2A7 gene or a 1:1 ortholog thereof. [PRO:DNx] HSDJ0798C17 OR2A7 OR2A7 PRO:000011750 Q96R45 Olfactory receptor 2A7 BAO_0201257 A protein that is a translation product of the human OR51T1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-26 OR51T1 OR51T1 PRO:000011878 Q8NGJ9 Olfactory receptor 51T1 BAO_0201258 A protein that is a translation product of the human OR2T2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1-43 OR2T2 OR2T2 PRO:000011788 Q6IF00 Olfactory receptor 2T2 BAO_0201259 A protein that is a translation product of the human OR2T5 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1-62 OR2T5 OR2T5 PRO:000011796 Q6IEZ7 Olfactory receptor 2T5 BAO_0201260 A protein that is a translation product of the human OR14I1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR14I1 OR5BU1 OR14I1 A6ND48 PRO:000011712 Olfactory receptor 14I1 BAO_0201261 A protein that is a translation product of the human OR5K2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR3-9 OR5K2 OR5K2 PRO:000011937 Q8NHB8 Olfactory receptor 5K2 BAO_0201262 A protein that is a translation product of the human OR4A47 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-113 OR4A47 OR4A47 PRO:000011810 Q6IF82 Olfactory receptor 4A47 BAO_0201263 A protein that is a translation product of the human OR4F21 gene or a 1:1 ortholog thereof. [PRO:DNx] OR4F21 OR4F21P OR4F21 O95013 PRO:000011833 Olfactory receptor 4F21 BAO_0201264 A protein that is a translation product of the human OR5B3 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-239 OR5B3 OR5B3 PRO:000011922 Q8NH48 Olfactory receptor 5B3 BAO_0201265 A protein that is a translation product of the human OR9K2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR12-2 OR9K2 OR9K2 PRO:000012024 Q8NGE7 Olfactory receptor 9K2 BAO_0201266 A protein that is a translation product of the human OR4Q3 gene or a 1:1 ortholog thereof. [PRO:DNx] C14orf13 OR4Q3 OR4Q3 PRO:000011852 Q8NH05 Olfactory receptor 4Q3 BAO_0201267 A protein that is a translation product of the human OR4M1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR14-7 OR4M1 OR4M1 PRO:000011846 Q8NGD0 Olfactory receptor 4M1 BAO_0201268 A protein that is a translation product of the human OR10J3 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1-25 OR10J3 OR10J3 PRO:000011674 Q5JRS4 Olfactory receptor 10J3 BAO_0201269 A protein that is a translation product of the human OR13G1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1-37 OR13G1 OR13G1 PRO:000011706 Q8NGZ3 Olfactory receptor 13G1 BAO_0201270 A protein that is a translation product of the human OR2J3 gene or a 1:1 ortholog thereof. [PRO:DNx] 6M1-3 OR2J3 OR2J3 O76001 PRO:000011772 Olfactory receptor 2J3 BAO_0201271 A protein that is a translation product of the human OR14J1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR14J1 OR5U1 OR14J1 PRO:000011713 Q9UGF5 Olfactory receptor 14J1 BAO_0201272 A protein that is a translation product of the human OR10C1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR10C1 OR10C1P OR10C1 PRO:000011660 Q96KK4 Olfactory receptor 10C1 BAO_0201273 A protein that is a translation product of the human OR2A2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR2A17P OR2A2 OR2A2 PRO:000011745 Q6IF42 Olfactory receptor 2A2 BAO_0201274 A protein that is a translation product of the human OR1D2 gene or a 1:1 ortholog thereof. [PRO:DNx] MGC119942 OR1D2 OR1D2 P34982 PRO:000011719 Olfactory receptor 1D2 BAO_0201275 A protein that is a translation product of the human OR1F1 gene or a 1:1 ortholog thereof. [PRO:DNx] OLFMF OR1F1 OR1F1 O43749 PRO:000011724 Olfactory receptor 1F1 BAO_0201276 A protein that is a translation product of the human OR2C1 gene or a 1:1 ortholog thereof. [PRO:DNx] MGC163200 OR2C1 OR2C1 O95371 PRO:000011760 Olfactory receptor 2C1 BAO_0201277 A protein that is a translation product of the human OR3A1 gene or a 1:1 ortholog thereof. [PRO:DNx] OLFRA03 OR3A1 OR3A1 P47881 PRO:000011804 Olfactory receptor 3A1 BAO_0201278 A protein that is a translation product of the human OR3A2 gene or a 1:1 ortholog thereof. [PRO:DNx] OLFRA04 OR3A2 OR3A2 P47893 PRO:000011805 Olfactory receptor 3A2 BAO_0201279 A protein that is a translation product of the human OR2S2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR2S2 OR37A OR2S2 PRO:000011783 Q9NQN1 Olfactory receptor 2S2 BAO_0201280 A protein that is a translation product of the human OR13A1 gene or a 1:1 ortholog thereof. [PRO:DNx] FLJ16797 OR13A1 OR13A1 PRO:000011697 Q8NGR1 Olfactory receptor 13A1 BAO_0201281 A protein that is a translation product of the human OR5H6 gene or a 1:1 ortholog thereof. [PRO:DNx] OR3-11 OR5H6 OR5H6 PRO:000011933 Q8NGV6 Olfactory receptor 5H6 BAO_0201282 A protein that is a translation product of the human OR5H2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR3-10 OR5H2 OR5H2 PRO:000011932 Q8NGV7 Olfactory receptor 5H2 BAO_0201283 A protein that is a translation product of the human OR4K5 gene or a 1:1 ortholog thereof. [PRO:DNx] OR14-16 OR4K5 OR4K5 PRO:000011844 Q8NGD3 Olfactory receptor 4K5 BAO_0201284 A protein that is a translation product of the human OR2H2 gene or a 1:1 ortholog thereof. [PRO:DNx] FAT11 OR2H2 OR2H2 O95918 PRO:000011770 Olfactory receptor 2H2 BAO_0201285 A protein that is a translation product of the human OR51G1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-29 OR51G1 OR51G1 PRO:000011869 Q8NGK1 Olfactory receptor 51G1 BAO_0201286 A protein that is a translation product of the human OR11H2 gene or a 1:1 ortholog thereof. [PRO:DNx] C14orf15 OR11H2 OR11H2 PRO:000030985 Q8NH07 Olfactory receptor 11H2 BAO_0201287 A protein that is a translation product of the human OR51B4 gene or a 1:1 ortholog thereof. [PRO:DNx] HOR5'Beta1 OR51B4 OR51B4 PRO:000011861 Q9Y5P0 Olfactory receptor 51B4 BAO_0201288 A protein that is a translation product of the human OR51B2 gene or a 1:1 ortholog thereof. [PRO:DNx] HOR5'Beta3 OR51B2 OR51B2 PRO:000011860 Q9Y5P1 Olfactory receptor 51B2 BAO_0201289 A protein that is a translation product of the human OR52N1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-61 OR52N1 OR52N1 PRO:000011898 Q8NH53 Olfactory receptor 52N1 BAO_0201290 A protein that is a translation product of the human OR2A4 gene or a 1:1 ortholog thereof. [PRO:DNx] OR2A10 OR2A4 OR2A4 O95047 PRO:000011747 Olfactory receptor 2A4 BAO_0201291 A protein that is a translation product of the human OR4K1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR14-19 OR4K1 OR4K1 PRO:000011838 Q8NGD4 Olfactory receptor 4K1 BAO_0201292 A protein that is a translation product of the human OR5AC2 gene or a 1:1 ortholog thereof. [PRO:DNx] HSA1 OR5AC2 OR5AC2 PRO:000011911 Q9NZP5 Olfactory receptor 5AC2 BAO_0201293 A protein that is a translation product of the human OR11H1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11H1 OR22-1 OR11H1 PRO:000011689 Q8NG94 Olfactory receptor 11H1 BAO_0201294 A protein that is a translation product of the human OR4F17 gene or a 1:1 ortholog thereof. [PRO:DNx] OR4F11P OR4F17 OR4F17 PRO:000011832 Q8NGA8 Olfactory receptor 4F17 BAO_0201295 A protein that is a translation product of the human OR4K15 gene or a 1:1 ortholog thereof. [PRO:DNx] OR14-20 OR4K15 OR4K15 PRO:000011841 Q8NH41 Olfactory receptor 4K15 BAO_0201296 A protein that is a translation product of the human OR8J3 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-173 OR8J3 OR8J3 PRO:000012012 Q8NGG0 Olfactory receptor 8J3 BAO_0201297 A protein that is a translation product of the human OR51G2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-28 OR51G2 OR51G2 PRO:000011870 Q8NGK0 Olfactory receptor 51G2 BAO_0201298 A protein that is a translation product of the human OR51E2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR51E2 OR51E3P OR51E2 PRO:000011866 Q9H255 Olfactory receptor 51E2 BAO_0201299 A protein that is a translation product of the human OR4P4 gene or a 1:1 ortholog thereof. [PRO:DNx] OR4P3P OR4P4 OR4P4 PRO:000011851 Q8NGL7 Olfactory receptor 4P4 BAO_0201300 A protein that is a translation product of the human OR4C15 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-127 OR4C15 OR4C15 PRO:000011816 Q8NGM1 Olfactory receptor 4C15 BAO_0201301 A protein that is a translation product of the human OR4A5 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-111 OR4A5 OR4A5 PRO:000011811 Q8NH83 Olfactory receptor 4A5 BAO_0201302 A protein that is a translation product of the human OR4A16 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-117 OR4A16 OR4A16 PRO:000011809 Q8NH70 Olfactory receptor 4A16 BAO_0201303 A protein that is a translation product of the human OR4A15 gene or a 1:1 ortholog thereof. [PRO:DNx] OR11-118 OR4A15 OR4A15 PRO:000011808 Q8NGL6 Olfactory receptor 4A15 BAO_0201304 A protein that is a translation product of the human OR10W1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR10W1 OR10W1P OR10W1 PRO:000011684 Q8NGF6 Olfactory receptor 10W1 BAO_0201305 A protein that is a translation product of the human OR2AE1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR2AE1 OR2AE2 OR2AE1 PRO:000011751 Q8NHA4 Olfactory receptor 2AE1 BAO_0201306 A protein that is a translation product of the human OR6N2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1-23 OR6N2 OR6N2 PRO:000011978 Q8NGY6 Olfactory receptor 6N2 BAO_0201307 A protein that is a translation product of the human OR6K2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1-17 OR6K2 OR6K2 PRO:000011973 Q8NGY2 Olfactory receptor 6K2 BAO_0201308 A protein that is a translation product of the human OR2L5 gene or a 1:1 ortholog thereof. [PRO:DNx] OR2L11 OR2L5 OR2L5 PRO:000032450 Q8NG80 Olfactory receptor 2L5 BAO_0201309 A protein that is a translation product of the human OR2G3 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1-33 OR2G3 OR2G3 PRO:000011767 Q8NGZ4 Olfactory receptor 2G3 BAO_0201310 A protein that is a translation product of the human OR2G2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR1-32 OR2G2 OR2G2 PRO:000011766 Q8NGZ5 Olfactory receptor 2G2 BAO_0201311 A protein that is a translation product of the human OR2C3 gene or a 1:1 ortholog thereof. [PRO:DNx] OR2C3 OR2C4 OR2C3 PRO:000011761 Q8N628 Olfactory receptor 2C3 BAO_0201312 A protein that is a translation product of the human OR5V1 gene or a 1:1 ortholog thereof. [PRO:DNx] 6M1-21 OR5V1 OR5V1 PRO:000011954 Q9UGF6 Olfactory receptor 5V1 BAO_0201313 A protein that is a translation product of the human OR2B2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR2B2 OR2B2Q OR2B2 PRO:000011758 Q9GZK3 Olfactory receptor 2B2 BAO_0201314 A protein that is a translation product of the human OR12D3 gene or a 1:1 ortholog thereof. [PRO:DNx] MGC119267 OR12D3 OR12D3 PRO:000011696 Q9UGF7 Olfactory receptor 12D3 BAO_0201315 A protein that is a translation product of the human OR1A1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR17-7 OR1A1 OR1A1 PRO:000011715 Q9P1Q5 Olfactory receptor 1A1 BAO_0201316 A protein that is a translation product of the human OR1D5 gene or a 1:1 ortholog thereof. [PRO:DNx] C17orf2 OR1D5 OR1D5 P58170 PRO:000011721 Olfactory receptor 1D5 BAO_0201317 A protein that is a translation product of the human OR1E1 gene or a 1:1 ortholog thereof. [PRO:DNx] HGM071 OR1E1 OR1E1 P30953 PRO:000011722 Olfactory receptor 1E1 BAO_0201318 A protein that is a translation product of the human OR1E2 gene or a 1:1 ortholog thereof. [PRO:DNx] OR17-135 OR1E2 OR1E2 P47887 PRO:000011723 Olfactory receptor 1E2 BAO_0201319 A protein that is a translation product of the human OR1G1 gene or a 1:1 ortholog thereof. [PRO:DNx] OR17-130 OR1G1 OR1G1 P47890 PRO:000011726 Olfactory receptor 1G1 BAO_0201320 A protein that is a translation product of the human OR3A3 gene or a 1:1 ortholog thereof. [PRO:DNx] OR17-137 OR3A3 OR3A3 P47888 PRO:000011806 Olfactory receptor 3A3 BAO_0201321 A protein that is a translation product of the human OR6A2 gene or a 1:1 ortholog thereof. [PRO:DNx] I7 OR6A2 OR6A2 O95222 PRO:000011956 Olfactory receptor 6A2 BAO_0201322 A rhodopsin-like G-protein coupled receptor that is a translation product of the human HTR4 gene or a 1:1 ortholog thereof. The preferred ligand is 5-hydroxytryptamine (serotonin). [PRO:WCB] 5-HT4 5-HT4 receptor (two splicing variants L and S) 5-hydroxytryptamine (serotonin) receptor 4 serotonin receptor 4 5-HT4 PRO:000001100 5-Hydroxytryptamine receptor 4 BAO_0201323 GPR107 is a member of the LUSTR family of proteins found in both plants and animals, having similar topology to G protein-coupled receptors GCDRP LUSTR1 GPR107 Q5VW38 G protein-coupled receptor 107 BAO_0201324 A protein that is a translation product of the GPR137 gene or a 1:1 ortholog thereof. [PRO:DNx] GPR137A Transmembrane 7 superfamily member 1-like 1 protein GPR137 Q96N19 G protein-coupled receptor 137 BAO_0201325 OR51E1 is a putative olfactory receptor OR51E1P OR52A3P GPR136 Q8TCB6 Olfactory receptor 51E1 BAO_0201326 A protein that is a translation product of the GPR175 gene or a 1:1 ortholog thereof. [PRO:DNx] G protein-coupled receptor 175 TPRA40 GPR175 Q86W33 transmembrane protein, adipocyte asscociated 1 owl:Thing Aug 03, 2013 Magdalena J Przydzial, Barun Bhhatarai, Amar Koleti, Stephan Schurer G Protein-Coupled Receptor (GPCR) BioAssays ontology Contact: Stephan Schurer: sschurer at med.miami.edu or visit bioassayontology.org 1.1 Contributors are those that engage in discussions in the context of SIO (in alphabetical order): christopher baker joachim baran jerven bolleman alison callahan leonid chepelev kevin cohen melanie courtot geraint duck luke mccarthy jim mccusker jose miguel cruz-toledo robert hoehndorf simon jupp jin-dong kim dana klassen james malone chris mungall david osumi-sutherland nuria queralt alexandre riazanov matthias samwald robert stevens mark wilkinson natalia villanueva-rosales Michel Dumontier The semanticscience integrated ontology (SIO) provides a simple, integrated ontology (types, relations) for objects, processes and their attributes. This project provides foundational support for the Bio2RDF (http://bio2rdf.org) and SADI (http://sadiframework.org) projects. website: http://semanticscience.org email: sio-ontology@googlegroups.com mailing list: http://groups.google.com/group/sio-ontology use,share,modify,commercial; by attribution [http://creativecommons.org/licenses/by/3.0/]. Semanticscience Integrated Ontology (SIO) general class inclusion axioms: 'is part of' some 'physical entity' subClassOf 'is located in' some 'physical entity' role chains: 'has capability' o 'is realized in' -> 'is participant in' 0.9.14 1.1 BAO_0000179 Endpoint is a test results for a single or multiple bioassay records, e.g. percent inhibition. placeholder Endpoint BAO_0000818 Any substance (e.g. hormone, drug, functional group, etc.) that binds specifically and reversibly to another chemical entity to form a larger complex. A ligand may function as agonist or antagonist or other. Word origin: From Latin ligandus, gerundive of ligare ‘to bind’. GPCR ligand BAO_0200001 A 5-hydroxytryptamine receptor 1 that is a translation product of the HTR1A gene or a 1:1 ortholog thereof. [PRO:WCB] 5-HT1A 5HT1a ADRB2RL1 ADRBRL1 5-HT1A PRO:000001161 5-Hydroxytryptamine receptor 1A BAO_0200002 A 5-hydroxytryptamine receptor 1 that is a translation product of the HTR1B gene or a 1:1 ortholog thereof. [PRO:WCB] 5-HT1B 5-HT1DB HTR1D2 HTR1DB S12 5-HT1B PRO:000001162 5-Hydroxytryptamine receptor 1B BAO_0200003 A 5-hydroxytryptamine receptor 1 that is a translation product of the HTR1D gene or a 1:1 ortholog thereof. [PRO:WCB] 5-HT1D HT1DA HTR1DA HTRL RDC4 5-HT1D PRO:000001163 5-Hydroxytryptamine receptor 1D BAO_0200004 A 5-hydroxytryptamine receptor 1 that is a translation product of the HTR1E gene or a 1:1 ortholog thereof. [PRO:WCB] 5-HT1E 5-HT1E PRO:000001164 5-Hydroxytryptamine receptor 1E BAO_0200005 A 5-hydroxytryptamine receptor 1 that is a translation product of the HTR1F gene or a 1:1 ortholog thereof. [PRO:WCB] 5-HT1F 5HT6 HTR1EL MR77 5-HT1F PRO:000001165 5-Hydroxytryptamine receptor 1F BAO_0200006 A 5-hydroxytryptamine receptor 2 that is a translation product of the HTR2A gene or a 1:1 ortholog thereof. [PRO:WCB] 5-HT2A HTR2 5-HT2A PRO:000001166 5-Hydroxytryptamine receptor 2A BAO_0200007 A 5-hydroxytryptamine receptor 2 that is a translation product of the HTR2B gene or a 1:1 ortholog thereof. [PRO:WCB] 5-HT(2B) 5-HT2B 5-HT2B PRO:000001167 5-Hydroxytryptamine receptor 2B BAO_0200008 A 5-hydroxytryptamine receptor 2 that is a translation product of the HTR2C gene or a 1:1 ortholog thereof. [PRO:WCB] 5-HT2C 5-HTR2C HTR1C 5-HT2C PRO:000001168 5-Hydroxytryptamine receptor 2C BAO_0200009 A GPCRs receptor type classifying it by the type of ligand they preferentially bind. Lipidergic GPCRs bind ligands containing a lipid moiety. lipidergic receptor type BAO_0200010 A 5-hydroxytryptamine receptor 5 that is a translation product of the HTR5A gene or a 1:1 ortholog thereof. [PRO:WCB] 5-HT5A MGC138226 5-HT5A PRO:000001169 5-Hydroxytryptamine receptor 5A BAO_0200011 A rhodopsin-like G protein-coupled receptor that is a translation product of the HTR6 gene or a 1:1 ortholog thereof. The preferred ligand is 5-hydroxytryptamine (serotonin). [PRO:WCB] 5-HT6 5-HT6R 5-HT6 PRO:000001102 5-Hydroxytryptamine receptor 6 BAO_0200012 A rhodopsin-like G protein-coupled receptor that is a translation product of the HTR7 gene or a 1:1 ortholog thereof. The preferred ligand is 5-hydroxytryptamine (serotonin). [PRO:WCB] 5-HT7 5-HT7 PRO:000001103 5-Hydroxytryptamine receptor 7 BAO_0200013 A muscarinic acetylcholine receptor that is a translation product of the CHRM1 gene or a 1:1 ortholog thereof. This receptor mediates slow excitatory postsynaptic potential in the postganglionic nerve and is also expressed in exocrine glands and in the central nervous system. [PRO:WCB] HM1 M1 M1R MGC30125 M1 PRO:000001613 Muscarinic acetylcholine receptor M1 BAO_0200014 A muscarinic acetylcholine receptor that is a translation product of the CHRM2 gene or a 1:1 ortholog thereof. This receptor is expressed in cardiac tissues and acts to slow the heart rate to normal after sympathetic nervous system stimulation. [PRO:WCB, Wikipedia:Muscarinic_acetylcholine_receptor] FLJ43243 HM2 MGC120006 MGC120007 M2 PRO:000001614 Muscarinic acetylcholine receptor M2 BAO_0200015 A muscarinic acetylcholine receptor that is a translation product of the CHRM3 gene or a 1:1 ortholog thereof. This receptor is expressed in many glands, in lungs, and in the smooth muscles of blood vessels. [PRO:WCB, Wikipedia:Muscarinic_acetylcholine_receptor] HM3 M3 PRO:000001615 Muscarinic acetylcholine receptor M3 BAO_0200016 A muscarinic acetylcholine receptor that is a translation product of the CHRM4 gene or a 1:1 ortholog thereof. This receptor is expressed in the central nervous system. [PRO:WCB, Wikipedia:Muscarinic_acetylcholine_receptor] HM4 M4R M4 PRO:000001616 Muscarinic acetylcholine receptor M4 BAO_0200017 A muscarinic acetylcholine receptor that is a translation product of the CHRM5 gene or a 1:1 ortholog thereof. Its expression pattern is yet to be elucidated. [PRO:WCB, Wikipedia:Muscarinic_acetylcholine_receptor] HM5 MGC41838 M5 PRO:000001617 Muscarinic acetylcholine receptor M5 BAO_0200018 An adenosine receptor that is a translation product of the ADORA1 gene or a 1:1 ortholog thereof. [PRO:WCB] RDC7 A1 PRO:000001575 Adenosine receptor A1 BAO_0200019 An adenosine receptor that is a translation product of the ADORA2A gene or a 1:1 ortholog thereof. [PRO:WCB] ADORA2 RDC8 hA2aR A2A PRO:000001576 Adenosine receptor A2a BAO_0200020 An adenosine receptor that is a translation product of the ADORA2B gene or a 1:1 ortholog thereof. [PRO:WCB] ADORA2 A2B PRO:000001577 Adenosine receptor A2b BAO_0200021 An adenosine receptor that is a translation product of the ADORA3 gene or a 1:1 ortholog thereof. [PRO:WCB] A3AR AD026 bA552M11.5 A3 PRO:000001578 Adenosine receptor A3 BAO_0200031 A rhodopsin-like G protein-coupled receptor that is a translation product of the C3AR1 gene or a 1:1 ortholog thereof. The preferred ligand is C3a anaphylatoxin. [PRO:WCB] AZ3B C3AR HNFAG09 C3a PRO:000001104 C3a anaphylatoxin chemotactic receptor BAO_0200032 A C5a anaphylatoxin chemotactic receptor that is a translation product of the C5AR1 gene or a 1:1 ortholog thereof. The preferred ligand is C5a anaphylatoxin. [PRO:WCB] C5A C5AR C5R1 CD88 C5a PRO:000001173 C5a anaphylatoxin chemotactic receptor BAO_0200033 A C5a anaphylatoxin chemotactic receptor that is a translation product of the GPR77 gene or a 1:1 ortholog thereof. Preferred ligands are C5a, C4a and C3a and their desarginated derivatives. Couples weakly to Gi-mediated signaling pathways. [PRO:WCB, UniProtKB:Q9P296] C5L2 GPF77 C5L2 PRO:000001174 C5a anaphylatoxin chemotactic receptor 2 BAO_0200034 An angiotensin II receptor 1 that is a translation product of the AGTR1 gene or a 1:1 ortholog thereof. [PRO:WCB] AG2S AGTR1A AGTR1B AT1 AT1B AT1R AT2R1 AT1 PRO:000001251 Type-1 angiotensin II receptor BAO_0200035 An angiotensin II receptor that is a translation product of the AGTR2 gene or a 1:1 ortholog thereof. [PRO:WCB] AT2 ATGR2 MRX88 AT2 PRO:000001191 Type-2 angiotensin II receptor BAO_0200037 A bombesin receptor that is a translation product of the NMBR gene or a 1:1 ortholog thereof. The preferred ligand is neuromedin-B. [PRO:WCB] NMBR NMBR PRO:000001241 Neuromedin-B receptor BAO_0200038 A bombesin receptor that is a translation product of the GRPR gene or a 1:1 ortholog thereof. The preferred ligand is gastrin releasing peptide. [PRO:WCB] GRPR GRPR PRO:000001223 Gastrin-releasing peptide receptor BAO_0200039 A bombesin receptor that is a translation product of the BRS3 gene or a 1:1 ortholog thereof. It has low affinity for the known bombesin-related peptides and is currently classed as an orphan receptor. [PRO:WCB] BRS3 BRS3 PRO:000001196 Bombesin receptor subtype-3 BAO_0200040 A bradykinin receptor that is a translation product of the BDKRB1 gene or a 1:1 ortholog thereof. The preferred ligand is bradykinin. [PRO:WCB] B1BKR B1R BKB1R BKR1 BRADYB1 B1 PRO:000001171 B1 bradykinin receptor BAO_0200041 A bradykinin receptor that is a translation product of the BDKRB2 gene or a 1:1 ortholog thereof. The preferred ligand is bradykinin. [PRO:WCB] B2R BK-2 BK2 BKR2 BRB2 DKFZp686O088 B2 PRO:000001172 B2 bradykinin receptor BAO_0200042 A rhodopsin-like G protein-coupled receptor that is a translation product of the CNR1 gene or a 1:1 ortholog thereof. Preferred ligands are cannabinoids--molecules related to tetrahydrocannabinol (THC), the psychoactive ingredient of cannabis. Endogenous cannabinoids serve as neurotransmitters. This receptor is expressed primarily in the brain. [PRO:WCB, Wikipedia:Cannabinoids] CANN6 CB-R CB1 CB1A CB1K5 CB1R CNR CB1 PRO:000001125 Cannabinoid receptor 1 BAO_0200043 A cannabinoid receptor 2 that is a translation product of the CNR2 gene or a 1:1 ortholog thereof. Preferred ligands are cannabinoids--molecules related to tetrahydrocannabinol (THC), the psychoactive ingredient of cannabis. This receptor is expressed primarily in the immune system. [PRO:WCB] CB2 CX5 CB2 PRO:000001126 Cannabinoid receptor 2 BAO_0200044 A chemokine receptor CCR1/3/1L that is a translation product of the CCR1 gene or a 1:1 ortholog thereof. [PRO:WCB] CD191 CKR-1 CKR1 CMKBR1 HM145 MIP1aR SCYAR1 CCR1 PRO:000001254 C-C chemokine receptor type 1 BAO_0200045 A chemokine receptor that is a translation product of the CCR2 gene or a 1:1 ortholog thereof. The preferred ligands include CCL2, CCL7, CCL8, CCL13. [PMID:12037138, PRO:WCB] CCR2 CCR2 PRO:000001199 C-C chemokine receptor type 2 BAO_0200046 A chemokine receptor CCR1/3/1L that is a translation product of the CCR3 gene or a 1:1 ortholog thereof. [PMID:12037138, PRO:WCB] CC-CKR-3 CD193 CKR3 CMKBR3 MGC102841 CCR3 PRO:000001255 C-C chemokine receptor type 3 BAO_0200047 A chemokine receptor that is a translation product of the CCR4 gene or a 1:1 ortholog thereof. The preferred ligands include CCL17 and CCL22. [PMID:12037138, PRO:WCB] CC-CKR-4 CD194 CKR4 CMKBR4 ChemR13 HGCN:14099 K5-5 CCR4 PRO:000001200 C-C chemokine receptor type 4 BAO_0200048 A chemokine receptor that is a translation product of the CCR5 gene or a 1:1 ortholog thereof. The preferred ligands include CCL3, CCL4, CCL5, CCL8, CCL14. [PMID:12037138, PRO:WCB] CC-CKR-5 CCCKR5 CD195 CKR-5 CKR5 CMKBR5 FLJ78003 CCR5 PRO:000001201 C-C chemokine receptor type 5 BAO_0200049 A chemokine receptor that is a translation product of the CCR6 gene or a 1:1 ortholog thereof. The preferred ligand is CCL20. [PMID:12037138, PRO:WCB] BN-1 C-C CKR-6 CC-CKR-6 CCR-6 CD196 CKR-L3 CKRL3 CCR6 PRO:000001202 C-C chemokine receptor type 6 BAO_0200050 A chemokine receptor that is a translation product of the CCR7 gene or a 1:1 ortholog thereof. The preferred ligands are CCL19 and CCL21. [PMID:12037138, PRO:WCB] BLR2 CD197 CDw197 CMKBR7 EBI1 CCR7 PRO:000001203 C-C chemokine receptor type 7 BAO_0200051 A chemokine receptor that is a translation product of the CCR8 gene or a 1:1 ortholog thereof. The preferred ligands include CCL1, CCL4, CCL17. [PMID:12037138, PRO:WCB] CC-CKR-8 CCR-8 CDw198 CKRL1 CMKBR8 CMKBRL2 CY6 CCR8 PRO:000001204 C-C chemokine receptor type 8 BAO_0200052 A chemokine receptor that is a translation product of the CCR9 gene or a 1:1 ortholog thereof. The preferred ligand is CCL25. [PMID:12037138, PRO:WCB] CDw199 GPR-9-6 GPR28 CCR9 PRO:000001205 C-C chemokine receptor type 9 BAO_0200053 A chemokine receptor that is a translation product of the CCR10 gene or a 1:1 ortholog thereof. The preferred ligands are CCL27 and CCL28. [PMID:10781587, PRO:WCB] GPR2 CCR10 PRO:000001198 C-C chemokine receptor type 10 BAO_0200054 A high affinity interleukin-8 receptor that is a translation product of the IL8RA gene or a 1:1 ortholog thereof. [PRO:WCB] C-C C-C-CKR-1 CD128 CD181 CDw128a CKR-1 CMKAR1 CXCR1 PRO:000001256 C-X-C chemokine receptor type 1 BAO_0200055 A high affinity interleukin-8 receptor that is a translation product of the IL8RB gene or a 1:1 ortholog thereof. [PRO:WCB] CD182 CDw128b CMKAR2 IL8R2 IL8RA IL8RB CXCR2 PRO:000001257 C-X-C chemokine receptor type 2 BAO_0200056 A chemokine receptor that is a translation product of the CXCR3 gene or a 1:1 ortholog thereof. The preferred ligands include CXCL9, CXCL10, CXCL11. [PMID:12037138, PRO:WCB] CD182 CD183 CKR-L2 CMKAR3 GPR9 IP10-R Mig-R CXCR3 PRO:000001207 C-X-C chemokine receptor type 3 BAO_0200057 A chemokine receptor that is a translation product of the CXCR4 gene or a 1:1 ortholog thereof. The preferred ligand is CXCL12. [PMID:12037138, PRO:WCB] CD184 D2S201E FB22 HM89 HSY3RR LAP3 LCR1 CXCR4 PRO:000001208 C-X-C chemokine receptor type 4 BAO_0200058 A chemokine receptor that is a translation product of the CXCR5 gene or a 1:1 ortholog thereof. The preferred ligand is CXCL13. [PMID:12037138, PRO:WCB] BLR1 CD185 MDR15 MGC117347 CXCR5 PRO:000001209 C-X-C chemokine receptor type 5 BAO_0200059 A chemokine receptor that is a translation product of the CXCR6 gene or a 1:1 ortholog thereof. The preferred ligand is CXCL16. [PMID:12037138, PRO:WCB] BONZO CD186 STRL33 TYMSTR CXCR6 PRO:000001210 C-X-C chemokine receptor type 6 BAO_0200060 A chemokine receptor that is a translation product of the CX3CR1 gene or a 1:1 ortholog thereof. The preferred ligand is CX3CL1. [PMID:12037138, PRO:WCB] CCRL1 CMKBRL1 CMKDR1 GPR13 GPRV28 V28 CX3CR1 PRO:000001206 CX3C chemokine receptor 1 BAO_0200061 A chemokine receptor that is a translation product of the XCR1 gene or a 1:1 ortholog thereof. The preferred ligands are XCL1 and XCL2. [PMID:12037138, PRO:WCB] CCXCR1 GPR5 XCR1 PRO:000001212 Chemokine XC receptor 1 BAO_0200062 A cholecystokinin receptor that is a translation product of the CCKAR gene or a 1:1 ortholog thereof. The preferred ligand is sulfated CCK, which is bound with a 500- to 1000-fold higher affinity than sulfated gastrin or nonsulfated CCK. [PMID:10581329, PRO:WCB] CCK-A CCK1-R CCKRA CCK1 PRO:000001216 Cholecystokinin receptor type A BAO_0200063 A cholecystokinin receptor that is a translation product of the CCKBR gene or a 1:1 ortholog thereof. The active receptor binds sulfated and non-sulfated forms of gastrin and CCK and their analogs. [PMID:10581329, PRO:WCB] CCK-B CCK2R GASR CCK2 PRO:000001217 Gastrin/cholecystokinin type B receptor BAO_0200064 A D(1)-like dopamine receptor that is a translation product of the DRD1 gene or a 1:1 ortholog thereof. [PRO:WCB] DADR DRD1A D1 PRO:000001175 D(1A) dopamine receptor BAO_0200065 A D(2)-like dopamine receptor that is a translation product of the DRD2 gene or a 1:1 ortholog thereof. [PRO:WCB] D2DR D2R D2 PRO:000001177 D(2) dopamine receptor BAO_0200066 A D(2)-like dopamine receptor that is a translation product of the DRD3 gene or a 1:1 ortholog thereof. [PRO:WCB] D3DR ETM1 FET1 MGC149204 MGC149205 D3 PRO:000001178 D(3) dopamine receptor BAO_0200067 A D(2)-like dopamine receptor that is a translation product of the DRD4 gene or a 1:1 ortholog thereof. [PRO:WCB] D4DR D4 PRO:000001179 D(4) dopamine receptor BAO_0200068 A D(1)-like dopamine receptor that is a translation product of the DRD5 gene or a 1:1 ortholog thereof. [PRO:WCB] DBDR DRD1B DRD1L2 MGC10601 D5 PRO:000001176 D(1B) dopamine receptor BAO_0200069 An endothelin receptor that is a translation product of the EDNRA gene or a 1:1 ortholog thereof. The active form binds endothelin 1 (ET-1) and ET-2 with much higher affinity than ET-3. [PMID:12037137, PRO:WCB] ETA ETAR ETRA ETA PRO:000001221 Endothelin-1 receptor BAO_0200070 An endothelin receptor that is a translation product of the EDNRB gene or a 1:1 ortholog thereof. The active form binds endothelin 1 (ET-1), ET-2, and ET-3 with equal affinity. [PMID:12037137, PRO:WCB] ABCDS ETB ETBR ETRB HSCR HSCR2 WS4A ETB PRO:000001222 Endothelin B receptor BAO_0200072 An N-formyl peptide receptor that is a translation product of the FPR1 gene or a 1:1 ortholog thereof. The preferred ligand is the peptide fMet-Leu-Phe, a bacterial peptide that acts as a chemoattractant in various pathophysiological conditions. [InterPro:IPR000826, PRO:WCB] FMLP FPR FPR1 PRO:000001580 fMet-Leu-Phe receptor BAO_0200073 An N-formyl peptide receptor that is a translation product of the FPR3 gene or a 1:1 ortholog thereof. [PRO:WCB] FML2_HUMAN FMLPY FPRH1 FPRH2 FPRL2 RMLP-R-I FPR3 PRO:000001567 N-formyl peptide receptor 3 BAO_0200074 A free fatty acid receptor that is a translation product of the FFAR1 gene or a 1:1 ortholog thereof. Its preferred ligands are medium and long-chain fatty acids. It potentiates fatty acid-stimulated insulin secretion in pancreatic islets. [PMID:17052194, PRO:WCB] FFA1R GPCR40 GPR40 FFA1 PRO:000001582 Free fatty acid receptor 1 BAO_0200075 A free fatty acid receptor that is a translation product of the FFAR2 gene or a 1:1 ortholog thereof. It mediates stimulation of adipogenesis by short-chain fatty acids. [PMID:17052194, PRO:WCB] FFA2R GPR43 FFA2 PRO:000001583 Free fatty acid receptor 2 BAO_0200076 A free fatty acid receptor that is a translation product of the FFAR3 gene or a 1:1 ortholog thereof. It mediates stimulation of leptin release by short-chain fatty acids. [PMID:17052194, PRO:WCB] FFA3R GPR41 FFA3 PRO:000001584 Free fatty acid receptor 3 BAO_0200077 A galanin receptor that is a translation product of the GALR2 gene or a 1:1 ortholog thereof. [PRO:WCB] GALNR2 MGC125983 MGC125984 GAL2 PRO:000001586 Galanin receptor type 2 BAO_0200078 A galanin receptor that is a translation product of the GALR3 gene or a 1:1 ortholog thereof. [PRO:WCB] GALR3 GAL3 PRO:000001587 Galanin receptor type 3 BAO_0200080 A glycoprotein hormone receptor that is a translation product of the FSHR gene or a 1:1 ortholog thereof. The preferred ligand is follitropin (follicle-stimulating hormone). [PRO:WCB] FSHRO LGR1 MGC141667 MGC141668 ODG1 FSH PRO:000001581 Follicle-stimulating hormone receptor BAO_0200081 A glycoprotein hormone receptor that is a translation product of the LHCGR gene or a 1:1 ortholog thereof. The preferred ligands are lutropin (luteinizing hormone) and choriogonadotropin (choriogonadotropic hormone). [PRO:WCB] FLJ41504 HHG LCGR LGR2 LH/CG-R LH/CGR LHR LH PRO:000001596 Lutropin-choriogonadotropic hormone receptor BAO_0200082 A glycoprotein hormone receptor that is a translation product of the TSHR gene or a 1:1 ortholog thereof. The preferred ligand is thyrotropin (thyroid-stimulating hormone). [PRO:WCB] CHNG1 LGR3 MGC75129 hTSHR-I TSH PRO:000001677 Thyrotropin receptor BAO_0200083 A gonadotropin-releasing hormone receptor that is a translation product of the GNRHR gene or a 1:1 ortholog thereof. The preferred ligand is gonadotropin-releasing hormone I. [PMID:11935410, PRO:WCB] GNRHR1 GRHR LHRHR LRHR GnRH PRO:000001588 Gonadotropin-releasing hormone receptor BAO_0200084 A gonadotropin-releasing hormone receptor that is a translation product of the GNRHR2 gene or a 1:1 ortholog thereof. The preferred ligand is gonadotropin-releasing hormone II. [PMID:11935410, PRO:WCB] GnRH-II-R GnRH2 PRO:000001589 Putative gonadotropin-releasing hormone II receptor BAO_0200085 A rhodopsin-like G protein-coupled receptor that is a translation product of the HRH1 gene or a 1:1 ortholog thereof. The preferred ligand is histamine. This receptor mediates smooth muscle contraction, NO formation, increased vascular permeability, and other diverse effects. [PMID:9311023, PRO:WCB] H1-R hisH1 H1 PRO:000001422 Histamine H1 receptor BAO_0200086 A rhodopsin-like G protein-coupled receptor that is a translation product of the HRH2 gene or a 1:1 ortholog thereof. The preferred ligand is histamine. This receptor mediates smooth muscle relaxation, gastric acid secretion, and other diverse effects. [PMID:9311023, PRO:WCB] H2R H2 PRO:000001423 Histamine H2 receptor BAO_0200087 An H3/H4 histamine receptor that is a translation product of the HRH3 gene or a 1:1 ortholog thereof. The preferred ligand is histamine. This receptor mediates inhibition of gastric acid release, inhibition of neurotransmitter release, and other diverse effects. [PMID:9311023, PRO:WCB] GPCR97 HH3R H3 PRO:000001564 Histamine H3 receptor BAO_0200088 An H3/H4 histamine receptor that is a translation product of the HRH4 gene or a 1:1 ortholog thereof. The preferred ligand is histamine. This receptor is expressed primarily in the bone marrow and eosinophils but also in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node. [PRO:WCB, UniProtKB:Q9H3N8] AXOR35 BG26 GPCR105 GPRv53 H4 H4R HH4R H4 PRO:000001565 Histamine H4 receptor BAO_0200089 A leukotriene B4 receptor that is a translation product of the LTB4R gene or a 1:1 ortholog thereof. [PRO:WCB] BLT1 BLTR CMKRL1 GPR16 LTB4R1 LTBR1 P2RY7 BLT1 PRO:000001594 Leukotriene B4 receptor 1 BAO_0200090 A leukotriene B4 receptor that is a translation product of the LTB4R2 gene or a 1:1 ortholog thereof. [PRO:WCB] BLT2 BLTR2 JULF2 KPG_004 LTB4-R 2 LTB4-R2 NOP9 BLT2 PRO:000001595 Leukotriene B4 receptor 2 BAO_0200091 A cysteinyl leukotriene receptor that is a translation product of the CYSLTR1 gene or a 1:1 ortholog thereof. The preferred ligand is the cysteinyl leukotriene D4. [PRO:WCB] CYSLT1 CYSLT1R CYSLTR HG55 HMTMF81 MGC46139 CysLT1 PRO:000001218 Cysteinyl leukotriene receptor 1 BAO_0200092 A cysteinyl leukotriene receptor that is a translation product of the CYSLTR2 gene or a 1:1 ortholog thereof. The preferred ligand is the cysteinyl leukotriene C4. [PRO:WCB] CYSLT2 CYSLT2R HG57 HPN321 KPG_011 hGPCR21 CysLT2 PRO:000001219 Cysteinyl leukotriene receptor 2 BAO_0200093 A rhodopsin-like G protein-coupled receptor that is a translation product of the OXER1 gene or a 1:1 ortholog thereof. The preferred ligands are eicosanoids and polyunsaturated fatty acids. [PRO:WCB, UniProtKB:Q8TDS5] GPCR GPR170 TG1019 OXE PRO:000001500 Oxoeicosanoid receptor 1 BAO_0200094 An N-formyl peptide receptor that is a translation product of the FPR2 gene or a 1:1 ortholog thereof. [PRO:WCB] ALXR FMLP-R-II FMLPX FPR2A FPRH1 FPRH2 FPRL1 FPR2/ALX PRO:000001566 N-formyl peptide receptor 2 BAO_0200095 A lysophosphatidic acid receptor 1/2/3 that is a translation product of the LPAR1 gene or a 1:1 ortholog thereof. It is expressed in many adult organs, including brain, heart, colon, small intestine, placenta, prostate, ovary, pancreas, testis, spleen, skeletal muscle, and kidney. There is little or no expression in liver, lung, thymus, or peripheral blood leukocytes. [PRO:WCB, UniProtKB:Q92633] EDG2 GPR26 Gpcr26 LPA1 Mrec1.3 VZG1 edg-2 LPA1 PRO:000001684 Lysophosphatidic acid receptor 1 BAO_0200096 A lysophosphatidic acid receptor 1/2/3 that is a translation product of the LPAR2 gene or a 1:1 ortholog thereof. It is expressed most abundantly in testis and peripheral blood leukocytes with less expression in pancreas, spleen, thymus and prostate. There is little or no expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon. [PRO:WCB, UniProtKB:Q9HBW0] EDG-4 EDG4 FLJ93869 LPA-2 LPA2 LPA2 PRO:000001685 Lysophosphatidic acid receptor 2 BAO_0200097 A lysophosphatidic acid receptor 1/2/3 that is a translation product of the LPAR3 gene or a 1:1 ortholog thereof. It is most abundantly expressed in prostate, testis, pancreas, and heart, with moderate levels in lung and ovary. There is no detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus, small intestine, colon, or peripheral blood leukocytes. [PRO:WCB, UniProtKB:Q9UBY5] EDG7 Edg-7 FLJ98231 GPCR HOFNH30 LP-A3 LPA3 LPA3 PRO:000001686 Lysophosphatidic acid receptor 3 BAO_0200098 A sphingosine 1-phosphate receptor 1-5 that is a translation product of the S1PR1 gene or a 1:1 ortholog thereof. The receptor is specifically expressed in endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin. [PRO:WCB, UniProtKB:P21453] CHEDG1 D1S3362 ECGF1 EDG-1 EDG1 FLJ58121 S1P1 S1P1 PRO:000001706 Sphingosine 1-phosphate receptor 1 BAO_0200099 A sphingosine 1-phosphate receptor 1-5 that is a translation product of the S1PR2 gene or a 1:1 ortholog thereof. [PRO:WCB] AGR16 EDG-5 EDG5 Gpcr13 H218 LPB2 S1P2 S1P2 PRO:000001707 Sphingosine 1-phosphate receptor 2 BAO_0200100 A sphingosine 1-phosphate receptor 1-5 that is a translation product of the S1PR3 gene or a 1:1 ortholog thereof. It is expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver. [PRO:WCB, UniProtKB:Q99500] EDG-3 EDG3 FLJ37523 FLJ93220 LPB3 MGC71696 S1P3 S1P3 PRO:000001708 Sphingosine 1-phosphate receptor 3 BAO_0200101 A sphingosine 1-phosphate receptor 1-5 that is a translation product of the S1PR4 gene or a 1:1 ortholog thereof. This receptor is specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. [PRO:WCB, UniProtKB:O95977] EDG6 LPC1 S1P4 SLP4 S1P4 PRO:000001709 Sphingosine 1-phosphate receptor 4 BAO_0200102 A sphingosine 1-phosphate receptor 1-5 that is a translation product of the S1PR5 gene or a 1:1 ortholog thereof. Although widely expressed in the brain, most prominently in the corpus callosum, it is detected at a low level in most tissues. [PRO:WCB, UniProtKB:Q9H228] EDG8 Edg-8 S1P5 SPPR-1 SPPR-2 S1P5 PRO:000001710 Sphingosine 1-phosphate receptor 5 BAO_0200103 A rhodopsin-like G protein-coupled receptor that is a translation product of the MCHR1 gene or a 1:1 ortholog thereof. The preferred ligand is melanin-concentrating hormone. This receptor is expressed in all mammals. [PRO:WCB, Wikipedia:Melanin-concentrating_hormone_receptor] GPR24 MCH1R MGC32129 SLC1 MCH1 PRO:000001144 Melanin-concentrating hormone receptor 1 BAO_0200104 A rhodopsin-like G protein-coupled receptor that is a translation product of the MCHR2 gene or a 1:1 ortholog thereof. The preferred ligand is melanin-concentrating hormone. This receptor is expressed in humans and in some primates and carnivores. [PRO:WCB, Wikipedia:Melanin-concentrating_hormone_receptor] GPR145 GPRv17 MCH-2R MCH-R2 MCH2 MCH2R MCHR-2 MCH2 PRO:000001145 Melanin-concentrating hormone receptor 2 BAO_0200105 A melanocortin receptor that is a translation product of the MC1R gene or a 1:1 ortholog thereof. [PRO:WCB] CMM5 MGC14337 MSH-R SHEP2 MC1 PRO:000001239 Melanocyte-stimulating hormone receptor BAO_0200106 A melanocortin receptor that is a translation product of the MC2R gene or a 1:1 ortholog thereof. The preferred ligand is ACTH. [PRO:WCB] ACTHR MGC125798 MC2 PRO:000001182 Adrenocorticotropic hormone receptor BAO_0200107 A melanocortin receptor that is a translation product of the MC3R gene or a 1:1 ortholog thereof. [PRO:WCB] BMIQ9 MC3 MC3-R OB20 OQTL MC3 PRO:000001236 Melanocortin receptor 3 BAO_0200108 A melanocortin receptor that is a translation product of the MC4R gene or a 1:1 ortholog thereof. [PRO:WCB] MGC126851 MGC138197 MC4 PRO:000001237 Melanocortin receptor 4 BAO_0200109 A melanocortin receptor that is a translation product of the MC5R gene or a 1:1 ortholog thereof. [PRO:WCB] MC2 MC5 PRO:000001238 Melanocortin receptor 5 BAO_0200110 An MT1-like melatonin receptor that is a translation product of the MTNR1A gene or a 1:1 ortholog thereof. The preferred ligand is melatonin. [PRO:WCB] MEL-1A-R MT1 MT1 PRO:000001609 Melatonin receptor type 1A BAO_0200111 An MT1-like melatonin receptor that is a translation product of the MTNR1B gene or a 1:1 ortholog thereof. The preferred ligand is melatonin. [PRO:WCB] FGQTL2 MEL-1B-R MT2 MT2 PRO:000001610 Melatonin receptor type 1B BAO_0200112 A neuromedin-U receptor that is a translation product of the NMUR1 gene or a 1:1 ortholog thereof. This receptor is expressed predominantly in peripheral tissues. [PMID:10899166, PRO:WCB] NMU NMU1 PRO:000001618 Neuromedin-U receptor 1 BAO_0200113 A neuromedin-U receptor that is a translation product of the NMUR2 gene or a 1:1 ortholog thereof. This receptor is expressed predominantly in the central nervous system. [PMID:10899166, PRO:WCB] FM-4 FM4 NMU-R2 NMU2R TGR-1 TGR1 NMU2 PRO:000001619 Neuromedin-U receptor 2 BAO_0200114 A neuropeptide FF receptor that is a translation product of the NPFFR1 gene or a 1:1 ortholog thereof. The preferred ligands are neuropeptides FF and AF. [PRO:WCB] FLJ10751 GPR147 NPFF1 NPFF1R1 OT7T022 NPFF1 PRO:000001620 Neuropeptide FF receptor 1 BAO_0200115 A neuropeptide FF receptor that is a translation product of the NPFFR2 gene or a 1:1 ortholog thereof. The preferred ligands are neuropeptides FF and AF. [PMID:10851242, PRO:WCB] GPR74 HLWAR77 NPFF2 NPGPR NPFF2 PRO:000001621 Neuropeptide FF receptor 2 BAO_0200116 A neuropeptides B/W receptor that is a translation product of the NPBWR1 gene or a 1:1 ortholog thereof. [PRO:WCB] GPR7 MGC129755 NPBW1 PRO:000001625 Neuropeptides B/W receptor type 1 BAO_0200117 A neuropeptides B/W receptor that is a translation product of the NPBWR2 gene or a 1:1 ortholog thereof. [PRO:WCB] GPR8 NPBW2 PRO:000001626 Neuropeptides B/W receptor type 2 BAO_0200118 A neuropeptide Y receptor 1/4/6 that is a translation product of the NPY1R gene or a 1:1 ortholog thereof. The preferred ligands are neuropeptides Y and YY. [PRO:WCB] NPY1R Y1 PRO:000001622 Neuropeptide Y receptor type 1 BAO_0200119 A rhodopsin-like G protein-coupled receptor that is a translation product of the NPY2R gene or a 1:1 ortholog thereof. The preferred ligands are neuropeptides YY and Y. This receptor is prominent in the brain and is involved in regulation of food intake, of gastrointestinal motility, of the cardiovascular system, and of neuronal excitability. [PMID:11287107, PRO:WCB] NPY2R Y2 PRO:000001493 Neuropeptide Y receptor type 2 BAO_0200120 A neuropeptide Y receptor 1/4/6 that is a translation product of the PPYR1 gene or a 1:1 ortholog thereof. The preferred ligand is pancreatic polypeptide. [PRO:WCB] MGC116897 NPY4-R NPY4R PP1 Y4 Y4 PRO:000001623 Neuropeptide Y receptor type 4 BAO_0200121 A rhodopsin-like G protein-coupled receptor that is a translation product of the NPY5R gene or a 1:1 ortholog thereof. The preferred ligands is neuropeptides Y and YY. [PRO:WCB] NPYR5 Y5 PRO:000001494 Neuropeptide Y receptor type 5 BAO_0200122 A G protein-coupled neurotensin receptor that is a translation product of the NTSR1 gene or a 1:1 ortholog thereof. [PRO:WCB] NTR NTS1 PRO:000001627 Neurotensin receptor type 1 BAO_0200123 A G protein-coupled neurotensin receptor that is a translation product of the NTSR2 gene or a 1:1 ortholog thereof. This receptor has a low affinity for neurotensin compared with neurotensin receptor 1 and neurotensin binding is selectively blocked by levocabastine. [PRO:WCB] NTR2 NTS2 PRO:000001628 Neurotensin receptor type 2 BAO_0200129 An opioid receptor that is a translation product of the OPRM1 gene or a 1:1 ortholog thereof. The preferred ligands are beta-endorphin and enkephalins. [PRO:WCB, Wikipedia:mu_Opioid_receptor] KIAA0403 LMOR MOR MOR1 OPRM OPRM1 PRO:000001612 Mu-type opioid receptor BAO_0200130 An opioid receptor that is a translation product of the OPRL1 gene or a 1:1 ortholog thereof. The preferred ligand is nociceptin. [PRO:WCB] KOR-3 MGC34578 NOCIR OOR ORL1 NOP PRO:000001631 Nociceptin receptor BAO_0200131 An orexin receptor that is a translation product of the HCRTR1 gene or a 1:1 ortholog thereof. [PRO:WCB] OX1R OX1 PRO:000001633 Orexin receptor type 1 BAO_0200132 An orexin receptor that is a translation product of the HCRTR2 gene or a 1:1 ortholog thereof. [PRO:WCB] OX2R OX2 PRO:000001634 Orexin receptor type 2 BAO_0200133 A P2Y purinoceptor 1/2/3/4/6 that is a translation product of the P2RY1 gene or a 1:1 ortholog thereof. The preferred ligand is ADP. [PRO:WCB] P2Y1 P2Y1 PRO:000001568 P2Y purinoceptor 1 BAO_0200134 A P2Y purinoceptor 1/2/3/4/6 that is a translation product of the P2RY2 gene or a 1:1 ortholog thereof. The preferred ligands are ATP and UTP. [PRO:WCB] HP2U MGC20088 MGC40010 P2RU1 P2U P2U1 P2UR P2Y2 PRO:000001572 P2Y purinoceptor 2 BAO_0200135 A P2Y purinoceptor 1/2/3/4/6 that is a translation product of the P2RY4 gene or a 1:1 ortholog thereof. The preferred ligand is UTP. [PRO:WCB] NRU P2P P2Y4 UNR P2Y4 PRO:000001573 P2Y purinoceptor 4 BAO_0200136 A P2Y purinoceptor 1/2/3/4/6 that is a translation product of the P2RY6 gene or a 1:1 ortholog thereof. The preferred ligand is UDP. [PRO:WCB] MGC15335 P2Y6 P2Y6 PRO:000001574 P2Y purinoceptor 6 BAO_0200137 A rhodopsin-like G protein-coupled receptor that is a translation product of the P2RY11 gene or a 1:1 ortholog thereof. The preferred ligands are ATP and ADP. [PRO:WCB, UniProtKB:Q96G91] P2Y11 P2Y11 PRO:000001436 P2Y purinoceptor 11 BAO_0200138 A P2RY12-like receptor that is a translation product of the P2RY12 gene or a 1:1 ortholog thereof. The preferred ligand is ADP. [PRO:WCB] ADPG-R HORK3 P2T(AC) P2Y(AC) P2Y(ADP) P2Y(cyc) P2Y12 P2Y12 PRO:000001569 P2Y purinoceptor 12 BAO_0200139 A P2RY12-like receptor that is a translation product of the P2RY13 gene or a 1:1 ortholog thereof. The preferred ligand is ADP. [PMID:11546776, PRO:WCB] GPCR1 GPR86 GPR94 P2Y13 SP174 P2Y13 PRO:000001570 P2Y purinoceptor 13 BAO_0200140 A P2RY12-like receptor that is a translation product of the P2RY14 gene or a 1:1 ortholog thereof. The preferred ligand is UDP-glucose. [PRO:WCB] GPR105 KIAA0001 P2Y14 P2Y14 PRO:000001571 P2Y purinoceptor 14 BAO_0200141 A prokineticin receptor that is a translation product of the PROKR1 gene or a 1:1 ortholog thereof. The preferred ligand is prokineticin 1. [PRO:WCB, UniProtKB:Q8TCW9] GPR73 GPR73a PKR1 ZAQ PKR1 PRO:000001653 Prokineticin receptor 1 BAO_0200142 A prokineticin receptor that is a translation product of the PROKR2 gene or a 1:1 ortholog thereof. The preferred ligand is prokineticin 2. [PRO:WCB, UniProtKB:Q8NFJ6] GPR73L1 GPR73b GPRg2 KAL3 PKR2 dJ680N4.3 PKR2 PRO:000001654 Prokineticin receptor 2 BAO_0200143 A prostanoid receptor that is a translation product of the PTGDR gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin D2 (PGD2). This receptor is found mainly in blood platelets, vascular smooth muscle, and nervous tissue. It is the least ubiquitous of the prostanoid receptors, almost always occurring in association with other prostanoid receptor types. [PMID:7938166, PRO:WCB] AS1 ASRT1 DP DP1 MGC49004 DP1 PRO:000001656 Prostaglandin D2 receptor BAO_0200144 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR44 gene or a 1:1 ortholog thereof. The preferred ligand is 11-dehydro-thromboxane B2. This receptor is not closely related to the prostaglandin D2 receptor encoded by PGD2. [PRO:WCB] CD294 CRTH2 DL1R DP2 DP2 PRO:000001547 Putative G protein-coupled receptor 44 BAO_0200145 A prostanoid receptor that is a translation product of the PTGER1 gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin E2 (PGE2). This receptor has limited expression, although it is more evident in rodents than in other mammals. [PMID:7938166, PRO:WCB] EP1 EP1 PRO:000001657 Prostaglandin E2 receptor EP1 subtype BAO_0200146 A prostanoid receptor that is a translation product of the PTGER2 gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin E2 (PGE2). This receptor is expressed mediates various effects, including relaxation of vascular smooth muscles, nonacid secretion from epithelial cells, inhibition of mediator release from mast cells and basophils, and activation of sensory afferent nerves. [PMID:7938166, PRO:WCB] EP2 EP2 PRO:000001658 Prostaglandin E2 receptor EP2 subtype BAO_0200147 A prostanoid receptor that is a translation product of the PTGER3 gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin E2 (PGE2). This receptor is the most ubiquitous of the prostaglandin E2 receptors, mediating contraction of gastrointestinal, uterine, and vascular smooth muscle, inhibition of neurotransmitter release from autonomic nerves, inhibition of lipolysis in adipocytes, inhibition of acid secretion from gastric mucosa, and inhibition of water reabsorption in kidney. [PMID:7938166, PRO:WCB] EP3 EP3-I EP3-II EP3-III EP3-IV EP3e MGC141828 EP3 PRO:000001659 Prostaglandin E2 receptor EP3 subtype BAO_0200148 A rhodopsin-like G protein-coupled receptor that is a translation product of the PTGER4 gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin E2. This receptor is not closely related to other prostaglandin E2 receptors. [PRO:WCB] EP4 EP4R MGC126583 EP4 PRO:000001548 Prostaglandin E2 receptor EP4 subtype BAO_0200149 A prostanoid receptor that is a translation product of the PTGFR gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin F2a. This receptor is particularly prevalent in the corpus luteum, but is expressed in other tissues also. [PMID:7938166, PRO:WCB] FP MGC120498 MGC46203 FP PRO:000001660 Prostaglandin F2-alpha receptor BAO_0200150 A prostanoid receptor that is a translation product of the PTGIR gene or a 1:1 ortholog thereof. The preferred ligand is prostacyclin (prostaglandin I2, PGI2). This receptor is widely distributed in blood platelets, vascular smooth muscle and nerve cells. [PMID:7938166, PRO:WCB] IP MGC102830 PRIPR IP1 PRO:000001655 Prostacyclin receptor BAO_0200151 A prostanoid receptor that is a translation product of the TBXA2R gene or a 1:1 ortholog thereof. The preferred ligand is thromboxane A2. This receptor is found mainly in vascular smooth muscle, where it mediates vasoconstriction, in platelets, where it mediates aggregation, and in airway smooth muscle. [PMID:7938166, PRO:WCB] TXA2-R TP PRO:000001676 Thromboxane A2 receptor BAO_0200152 A proteinase-activated receptor that is a translation product of the F2R gene or a 1:1 ortholog thereof. It is activated by thrombin, which cleaves the mature peptide, exposing a new amino end. The new N-terminal residues act as a tethered ligand that induces activity. [PMID:1672265, PRO:WCB] CF2R HTR PAR-1 PAR1 TR PAR1 PRO:000001661 Proteinase-activated receptor 1 BAO_0200153 A proteinase-activated receptor that is a translation product of the F2RL1 gene or a 1:1 ortholog thereof. It is activated by trypsin and trypsin-like proteinases, which cleave the mature peptide, exposing a new amino end. The six new N-terminal residues act as a tethered ligand that induces activity. [PMID:7556175, PRO:WCB] GPR11 PAR2 PAR2 PRO:000001662 Proteinase-activated receptor 2 BAO_0200154 A proteinase-activated receptor that is a translation product of the F2RL2 gene or a 1:1 ortholog thereof. It is activated by thrombin, which cleaves the mature peptide, exposing a new amino end. The six new N-terminal residues act as a tethered ligand that induces activity. [PMID:15582715, PRO:WCB] PAR3 PAR3 PRO:000001663 Proteinase-activated receptor 3 BAO_0200155 A proteinase-activated receptor that is a translation product of the F2RL3 gene or a 1:1 ortholog thereof. It is activated by thrombin and cathepsin G, which cleave the mature peptide, exposing a new amino end. The six new N-terminal residues act as a tethered ligand that induces activity. [PMID:10702240, PMID:9618465, PRO:WCB] PAR4 PAR4 PRO:000001664 Proteinase-activated receptor 4 BAO_0200156 A relaxin receptor that is a translation product of the RXFP1 gene or a 1:1 ortholog thereof. This receptor is expressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart. [PRO:WCB, UniProtKB:Q9HBX9] LGR7 LGR7.1 LGR7.10 LGR7.2 MGC138347 MGC142177 RXFPR1 RXFP1 PRO:000001666 Relaxin receptor 1 BAO_0200157 A relaxin receptor that is a translation product of the RXFP2 gene or a 1:1 ortholog thereof. This receptor is expressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells, and bone marrow. [PRO:WCB, UniProtKB:Q8WXD0] GPR106 GREAT INSL3R LGR8 LGR8.1 RXFPR2 RXFP2 PRO:000001667 Relaxin receptor 2 BAO_0200158 A rhodopsin-like G protein-coupled receptor that is a translation product of the RXFP3 gene or a 1:1 ortholog thereof. The preferred ligands are relaxin-3, bradykinin, and kallidin. [PRO:WCB, UniProtKB:Q8TDU9] GPCR135 MGC141998 MGC142000 RLN3R1 RXFPR3 SALPR RXFP3 PRO:000001552 Relaxin receptor 3 BAO_0200159 A rhodopsin-like G protein-coupled receptor that is a translation product of the RXFP4 gene or a 1:1 ortholog thereof. The preferred ligands are relaxin-3, bradykinin, and kallidin. [PRO:WCB, UniProtKB:Q8TDU9] GPCR142 GPR100 MGC126556 MGC126558 RLN3R2 RXFPR4 RXFP4 PRO:000001553 Relaxin receptor 4 BAO_0200160 A somatostatin receptor that is a translation product of the SSTR1 gene or a 1:1 ortholog thereof. [PRO:WCB] SRIF-2 SSTR1 SSTR1 PRO:000001668 Somatostatin receptor type 1 BAO_0200161 A somatostatin receptor that is a translation product of the SSTR2 gene or a 1:1 ortholog thereof. [PRO:WCB] SSTR2 SSTR2 PRO:000001669 Somatostatin receptor type 2 BAO_0200162 A somatostatin receptor that is a translation product of the SSTR3 gene or a 1:1 ortholog thereof. [PRO:WCB] SSTR3 SSTR3 PRO:000001670 Somatostatin receptor type 3 BAO_0200163 A somatostatin receptor that is a translation product of the SSTR4 gene or a 1:1 ortholog thereof. [PRO:WCB] SSTR4 SSTR4 PRO:000001671 Somatostatin receptor type 4 BAO_0200164 A somatostatin receptor that is a translation product of the SSTR5 gene or a 1:1 ortholog thereof. [PRO:WCB] SS-5-R SSTR5 SSTR5 PRO:000001672 Somatostatin receptor type 5 BAO_0200165 A tachykinin receptor that is a translation product of the TACR1 gene or a 1:1 ortholog thereof. The preferred ligand is substance-P. [PRO:WCB, Wikipedia:Tachykinin_receptor] NK1R NKIR SPR TAC1R NK1 PRO:000001247 Substance-P receptor BAO_0200166 A tachykinin receptor that is a translation product of the TACR2 gene or a 1:1 ortholog thereof. The preferred ligand is neurokinin A, also known as substance-K. [PRO:WCB, Wikipedia:Tachykinin_peptides, Wikipedia:Tachykinin_receptor] NK2R NKNAR SKR TAC2R NK2 PRO:000001246 Substance-K receptor BAO_0200167 A tachykinin receptor that is a translation product of the TACR3 gene or a 1:1 ortholog thereof. The preferred ligand is neurokinin B, also known as neuromedin-K. [PRO:WCB, Wikipedia:Tachykinin_peptides, Wikipedia:Tachykinin_receptor] MGC148060 MGC148061 NK-3R NK3R NKR TAC3RL NK3 PRO:000001242 Neuromedin-K receptor BAO_0200168 A vasopressin/oxytocin receptor that is a translation product of the AVPR1A gene or a 1:1 ortholog thereof. The preferred ligand is vasopressin. The receptor is expressed in vascular smooth muscle cells, hepatocytes, platelets, brain cells, and uterus cells. [PRO:WCB, Wikipedia:Vasopressin_receptor] AVPR1 V1A PRO:000001681 Vasopressin V1a receptor BAO_0200169 A vasopressin/oxytocin receptor that is a translation product of the AVPR1B gene or a 1:1 ortholog thereof. The preferred ligand is vasopressin. The receptor is expressed in cells in the anterior pituitary and throughout the brain. [PRO:WCB, Wikipedia:Vasopressin_receptor] AVPR3 V1B PRO:000001682 Vasopressin V1b receptor BAO_0200170 A vasopressin/oxytocin receptor that is a translation product of the AVPR2 gene or a 1:1 ortholog thereof. The preferred ligand is vasopressin. The receptor is expressed in kidney tubule, fetal lung, lung cancer, and liver. [PRO:WCB, Wikipedia:Vasopressin_receptor] ADHR DI1 DIR DIR3 MGC126533 MGC138386 NDI V2 PRO:000001683 Vasopressin V2 receptor BAO_0200171 A vasopressin/oxytocin receptor that is a translation product of the OXTR gene or a 1:1 ortholog thereof. The preferred ligand is oxytocin. [PRO:WCB] OT-R OT PRO:000001635 Oxytocin receptor BAO_0200172 A chemokine receptor that is a translation product of the CCRL2 gene or a 1:1 ortholog thereof. The preferred ligands may be CCL2, CCL5, CCL7, CCL8. The signaling pathway is not known. [PMID:12885941, PRO:WCB] CKRX CRAM CRAM-A CRAM-B FLJ55815 HCR MGC116710 CCRL2 PRO:000001214 Chemokine receptor-like protein CCRL2 BAO_0200173 A rhodopsin-like G protein-coupled receptor that is a translation product of the CMKLR1 gene or a 1:1 ortholog thereof. [PRO:WCB] CHEMERINR ChemR23 DEZ MGC126105 MGC126106 CMKLR1 PRO:000001129 Chemokine-like receptor 1 BAO_0200175 A rhodopsin-like G protein-coupled receptor that is a translation product of the EBI2 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] EBI2 EBI2 PRO:000001109 G protein-coupled receptor 183 BAO_0200176 A rhodopsin-like G protein-coupled receptor whose active form binds free fatty acid. In humans there are four tandem genes located downstream of CD22 on chromosome 19. One of these, GPR42P, is a pseudogene formed by recent duplication of FFAR3. [PMID:15684720, PMID:17052194, PRO:WCB] FFAR1L FFAR3L GPR41L GPR42P GPR42 PRO:000001452 G protein-coupled receptor 42 BAO_0200177 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR1 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PMID:15914470, PRO:WCB] GPR1 GPR1 PRO:000001502 G protein-coupled receptor 1 BAO_0200178 A GPR6-like G protein-coupled receptor that is a translation product of the GPR3 gene or a 1:1 ortholog thereof. The preferred ligand is reported to be sphingosine 1-phosphate. It is currently classed as an orphan receptor. [PMID:12220620, PRO:WCB] ACCA GPR3 PRO:000001643 G protein-coupled receptor 3 BAO_0200179 A GPR4-like G protein-coupled receptor that is a translation product of the GPR4 gene or a 1:1 ortholog thereof. [PRO:WCB] - GPR4 PRO:000001644 G protein-coupled receptor 4 BAO_0200180 A GPR6-like G protein-coupled receptor that is a translation product of the GPR6 gene or a 1:1 ortholog thereof. The preferred ligand is reported to be sphingosine 1-phosphate. It is currently classed as an orphan receptor. [PMID:12220620, PRO:WCB] - GPR6 PRO:000001674 G protein-coupled receptor 6 BAO_0200181 A GPR6-like G protein-coupled receptor that is a translation product of the GPR12 gene or a 1:1 ortholog thereof. The preferred ligand is reported to be sphingosine 1-phosphate. It is currently classed as an orphan receptor. [PMID:12220620, PRO:WCB] FLJ18149 FLJ97704 GPCR12 GPCR21 MGC138349 MGC138351 GPR12 PRO:000001636 G protein-coupled receptor 12 BAO_0200182 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR15 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] MGC126828 MGC126830 GPR15 PRO:000001418 G protein-coupled receptor 15 BAO_0200183 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR17 gene or a 1:1 ortholog thereof. The preferred ligands are uracil nucleotides and cysteinyl leukotrienes. It is highly expressed in brain, heart and kidney. [PMID:16990797, PRO:WCB] DKFZp686M18273 GPR17 PRO:000001560 G protein-coupled receptor 17 BAO_0200184 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR18 gene or a 1:1 ortholog thereof. The preferred ligand is reported to be N-arachidonyl glycine. It is currently classed as an orphan receptor. [PMID:16844083, PRO:WCB] GPR18 GPR18 PRO:000001430 G protein-coupled receptor 18 BAO_0200185 A rhodopsin-like G protein-coupled receptor 19 that is a translation product of the GPR19 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] - GPR19 PRO:000001520 G protein-coupled receptor 19 BAO_0200186 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR20 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] - GPR20 PRO:000001521 G protein-coupled receptor 20 BAO_0200188 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR22 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] MGC129847 GPR22 PRO:000001523 G protein-coupled receptor 22 BAO_0200189 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR25 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] - GPR25 PRO:000001524 G protein-coupled receptor 25 BAO_0200190 A G protein-coupled receptor 26/78 that is a translation product of the GPR26 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] DKFZp761H2121 FLJ33774 MGC138216 GPR26 PRO:000001641 G protein-coupled receptor 26 BAO_0200191 A G protein-coupled receptor 27/85/173 that is a translation product of the GPR27 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] SREB1 GPR27 PRO:000001642 G protein-coupled receptor 27 BAO_0200192 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR31 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] - GPR31 PRO:000001527 G protein-coupled receptor 31 BAO_0200193 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR32 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] - GPR32 PRO:000001528 G protein-coupled receptor 32 BAO_0200194 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR33 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. GPR33 has undergone independent pseudogenization in human, chimpanzee, orangutan, siamang and rat. [PRO:WCB, UniProtKB:Q49SQ1] - GPR33 PRO:000001529 G protein-coupled receptor 33 BAO_0200195 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR34 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] - GPR34 PRO:000001530 G protein-coupled receptor 34 BAO_0200196 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR35 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. This receptor is widely expressed in adult and fetal tissues. [PRO:WCB, UniProtKB:Q9HC97] - GPR35 PRO:000001531 G protein-coupled receptor 35 BAO_0200197 An rhodopsin-like G protein-coupled receptor that is a translation product of the GPR37 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] EDNRBL PAELR hET(B)R-LP GPR37 PRO:000001148 G protein-coupled receptor 37 BAO_0200198 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR37L1 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. Although about 50% identical to G protein-coupled receptor 37 over a carboxyl-terminal span of about 360 residues, the amino-terminal region of about 120 residues is dissimilar and about 120 residues shorter. [PRO:WCB] ET(B)R-LP-2 ETBR-LP-2 GPR37L1 PRO:000001112 G protein-coupled receptor 37L1 BAO_0200199 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR39 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] MGC149541 GPR39 PRO:000001532 G protein-coupled receptor 39 BAO_0200200 A G protein-coupled receptor 45/63 that is a translation product of the GPR45 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. This receptor is expressed in brain particularly in the basal forebrain, frontal cortex, and caudate, but not in thalamus, hippocampus, or putamen. [PRO:WCB, UniProtKB:Q9Y5Y3] PSP24 PSP24(ALPHA) PSP24A GPR45 PRO:000001645 G protein-coupled receptor 45 BAO_0200201 An MT1-like melatonin receptor that is a translation product of the GPR50 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] H9 MGC125342 Mel1c GPR50 PRO:000001611 G protein-coupled receptor 50 BAO_0200202 A G protein-coupled receptor 21/52 that is a translation product of the GPR52 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] MGC111751 GPR52 PRO:000001646 G protein-coupled receptor 52 BAO_0200203 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR55 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] - GPR55 PRO:000001534 G protein-coupled receptor 55 BAO_0200204 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR61 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] BALGR GPCR3 GPR61 PRO:000001535 G protein-coupled receptor 61 BAO_0200205 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR62 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] GPCR8 KPG_005 MGC26943 GPR62 PRO:000001536 G protein-coupled receptor 62 BAO_0200206 A G protein-coupled receptor 45/63 that is a translation product of the GPR63 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. This receptor is predominantly expressed in the brain. [PMID:11027574, PRO:WCB] PSP24(beta) PSP24B GPR63 PRO:000001647 G protein-coupled receptor 63 BAO_0200207 A GPR4-like G protein-coupled receptor that is a translation product of the GPR65 gene or a 1:1 ortholog thereof. The preferred ligand is reported to be psychosine. It is currently classed as an orphan receptor. [PMID:11309421, PRO:WCB] TDAG8 hTDAG8 GPR65 PRO:000001665 G protein-coupled receptor 65 BAO_0200208 A GPR4-like G protein-coupled receptor that is a translation product of the GPR68 gene or a 1:1 ortholog thereof. The preferred ligand is reported to be sphingosylphosphorylcholine. It is currently classed as an orphan receptor. [PMID:10806476, PRO:WCB] GPR12A MGC111379 MGC156983 OGR1 GPR68 PRO:000001675 G protein-coupled receptor 68 BAO_0200209 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR75 gene or a 1:1 ortholog thereof. Although currently classified as an orphan receptor, it has been reported to be activated by the chemokine CCL5 (RANTES). [PMID:17001303, PRO:WCB] GPRchr2 MGC132002 WI31133 GPR75 PRO:000001537 G protein-coupled receptor 75 BAO_0200210 A G protein-coupled receptor 26/78 that is a translation product of the GPR78 gene or a 1:1 ortholog thereof. [PRO:WCB] - GPR78 PRO:000001648 G protein-coupled receptor 78 BAO_0200212 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR82 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] - GPR82 PRO:000001538 G protein-coupled receptor 82 BAO_0200213 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR83 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. This receptor is specifically expressed in brain. [PRO:WCB, UniProtKB:Q9NYM4] GIR GPR72 GPR83 PRO:000001539 G protein-coupled receptor 83 BAO_0200214 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR84 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. This receptor is expressed in brain, heart, muscle, colon, thymus, spleen, kidney, liver, placenta, intestine, bone marrow, lung and peripheral blood leukocytes. [PRO:WCB, UniProtKB:Q9NQS5] EX33 GPCR4 GPR84 PRO:000001540 G protein-coupled receptor 84 BAO_0200215 A G protein-coupled receptor 27/85/173 that is a translation product of the GPR85 gene or a 1:1 ortholog thereof. [PRO:WCB] FLJ50993 FLJ51159 FLJ99433 SREB SREB2 GPR85 PRO:000001650 G protein-coupled receptor 85 BAO_0200216 A P2RY12-like receptor that is a translation product of the GPR87 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] GPR95 KPG_002 MGC131898 GPR87 PRO:000001651 G protein-coupled receptor 87 BAO_0200217 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR88 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. This receptor is expressed in the striatum almost exclusively. [PMID:11056049, PRO:WCB] STRG GPR88 PRO:000001541 G protein-coupled receptor 88 BAO_0200218 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR101 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] GPCR6 GPR101 PRO:000001503 G protein-coupled receptor 101 BAO_0200219 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR119 gene or a 1:1 ortholog thereof. It is reported to bind oleoylethanolamide. It is currently classed as an orphan receptor. [PMID:16517404, PRO:WCB] GPCR2 MGC119957 GPR119 PRO:000001459 G protein-coupled receptor 119 BAO_0200220 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR120 gene or a 1:1 ortholog thereof. This receptor is abundantly expressed in intestine and is reported to bind free fatty acids. It is currently classed as an orphan receptor. [PMID:15619630, PRO:WCB] DKFZp686F0824 GPR129 GT01 MGC119984 PGR4 GPR120 PRO:000001417 G protein-coupled receptor 120 BAO_0200221 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR132 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] G2A MGC99642 GPR132 PRO:000001504 G protein-coupled receptor 132 BAO_0200222 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR135 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] HUMNPIIY20 GPR135 PRO:000001505 G protein-coupled receptor 135 BAO_0200223 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR139 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] GPRg1 PGR3 GPR139 PRO:000001506 G protein-coupled receptor 139 BAO_0200224 A rhodopsin-like G protein-coupled receptor 141 that is a translation product of the GPR141 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] PGR13 GPR141 PRO:000001507 G protein-coupled receptor 141 BAO_0200225 A rhodopsin-like G protein-coupled receptor 142 that is a translation product of the GPR142 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] PGR2 GPR142 PRO:000001508 G protein-coupled receptor 142 BAO_0200226 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR146 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] PGR8 GPR146 PRO:000001509 G protein-coupled receptor 146 BAO_0200227 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR148 gene or a 1:1 ortholog thereof. [PRO:WCB] GPR148 GPR148 PRO:000001510 G protein-coupled receptor 148 BAO_0200228 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR149 gene or a 1:1 ortholog thereof. [PRO:WCB] IEDA PGR10 GPR149 PRO:000001511 G protein-coupled receptor 149 BAO_0200229 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR150 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] PGR11 GPR150 PRO:000001512 G protein-coupled receptor 150 BAO_0200230 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR151 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] GALR4 GALRL GPCR PGR7 GPR151 PRO:000001513 G protein-coupled receptor 151 BAO_0200231 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR152 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] MGC148162 PGR5 GPR152 PRO:000001514 G protein-coupled receptor 152 BAO_0200232 A G protein-coupled receptor 153/162 that is a translation product of the GPR153 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] GPR153 GPR153 PRO:000001637 G protein-coupled receptor 153 BAO_0200233 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR160 gene or a 1:1 ortholog thereof. [PRO:WCB] GPCR1 GPCR150 GPR160 PRO:000001516 G protein-coupled receptor 160 BAO_0200234 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR161 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] FLJ33952 RE2 GPR161 PRO:000001517 G protein-coupled receptor 161 BAO_0200235 A G protein-coupled receptor 153/162 that is a translation product of the GPR162 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] A-2 FLJ78837 GRCA GPR162 PRO:000001638 G protein-coupled receptor 162 BAO_0200236 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR171 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] H963 GPR171 PRO:000001518 G protein-coupled receptor 171 BAO_0200237 A G protein-coupled receptor 27/85/173 that is a translation product of the GPR173 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] SREB3 GPR173 PRO:000001639 G protein-coupled receptor 173 BAO_0200238 A P2RY10-like receptor that is a translation product of the GPR174 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] - GPR174 PRO:000001640 G protein-coupled receptor 174 BAO_0200239 A rhodopsin-like G protein-coupled receptor that is a translation product of the GPR182 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] 7TMR ADMR AM-R AMR G10D MGC34399 gamrh GPR182 PRO:000001419 G protein-coupled receptor 182 BAO_0200240 A leucine-rich repeat-containing G protein-coupled receptor 4/5/6 that is a translation product of the LGR4 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] GPR48 LGR4 PRO:000001591 Leucine-rich repeat containing G protein-coupled receptor 4 BAO_0200241 A leucine-rich repeat-containing G protein-coupled receptor 4/5/6 that is a translation product of the LGR5 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] FEX GPR49 GPR67 GRP49 HG38 MGC117008 LGR5 PRO:000001592 Leucine-rich repeat containing G protein-coupled receptor 5 BAO_0200242 A leucine-rich repeat-containing G protein-coupled receptor 4/5/6 that is a translation product of the LGR6 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] FLJ14471 VTS20631 LGR6 PRO:000001593 Leucine-rich repeat containing G protein-coupled receptor 6 BAO_0200243 A mas-related G protein-coupled receptor that is a translation product of the MAS1 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] MAS MGC119966 MAS1 PRO:000001563 MAS1 oncogene BAO_0200244 A mas-related G protein-coupled receptor that is a translation product of the MAS1L gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] MAS-L MGC119987 MRG dJ994E9.2 MAS1L PRO:000001607 MAS1 oncogene-like BAO_0200245 A mas-related G protein-coupled receptor that is a translation product of the MRGPRD gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. It is reported to bind beta-alanine. [PMID:15037633, PRO:WCB] MRGD TGR7 MRGPRD PRO:000001602 MAS-related GPR, member D BAO_0200246 A mas-related G protein-coupled receptor that is a translation product of the MRGPRE gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] GPR167 MGC138408 MRGE MRGPRE PRO:000001603 MAS-related GPR, member E BAO_0200247 A mas-related G protein-coupled receptor that is a translation product of the MRGPRF gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] MRGPRF MRGPRF PRO:000001604 MAS-related GPR, member F BAO_0200248 A mas-related G protein-coupled receptor that is a translation product of the MRGPRG gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] GPR169 MRGG MRGPRG PRO:000001605 MAS-related GPR, member G BAO_0200249 A mas-related G protein-coupled receptor X that is a translation product of the MRGPRX1 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. This receptor is specific to a subset of small dorsal root and trigeminal sensory neurons. This receptor is strongly activated by bovine adrenal medulla peptide 22 (BAM22) and related peptides. [PMID:16284629, PRO:WCB, UniProtKB:Q96LB2] GPCR MRGX1 SNSR4 MRGPRX1 PRO:000001702 MAS-related GPR, member X1 BAO_0200250 A mas-related G protein-coupled receptor X that is a translation product of the MRGPRX2 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. This receptor has limited expression in peripheral and central nervous system, with highest levels in dorsal root ganglion. In contrast with the X1 receptor, it is activated by cortistatin-14 but only weakly by BAM22. [PMID:16284629, PRO:WCB, UniProtKB:Q96LB1] MRGX2 MRGPRX2 PRO:000001703 MAS-related GPR, member X2 BAO_0200251 A mas-related G protein-coupled receptor X that is a translation product of the MRGPRX3 gene or a 1:1 ortholog thereof. This receptor is specific to a subset of small dorsal root and trigeminal sensory neurons. [PRO:WCB, UniProtKB:Q96LB0] GPCR MRGX3 SNSR1 SNSR2 MRGPRX3 PRO:000001704 MAS-related GPR, member X3 BAO_0200252 A mas-related G protein-coupled receptor X that is a translation product of the MRGPRX4 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. This receptor is specific to ia subset of small dorsal root and trigeminal sensory neurons. [PRO:WCB, UniProtKB:Q96LA9] GPCR MGC129753 MGC129754 MRGX4 SNSR6 MRGPRX4 PRO:000001705 MAS-related GPR, member X4 BAO_0200253 An animal opsin that is a translation product of the OPN3 gene or a 1:1 ortholog thereof. [PRO:WCB] ECPN OPN3 PRO:000001220 Opsin 3 BAO_0200254 An animal opsin that is a translation product of the OPN5 gene or a 1:1 ortholog thereof. [PRO:WCB] GPR136 PGR12 TMEM13 OPN5 PRO:000001180 Opsin 5 BAO_0200255 A rhodopsin-like G protein-coupled receptor that is a translation product of the OXGR1 gene or a 1:1 ortholog thereof. The preferred ligand is 2-oxoglutarate (alpha-ketoglutarate). [PRO:WCB] GPR80 GPR99 MGC119206 MGC119207 MGC119208 P2RY15 P2Y15 OXGR1 PRO:000001097 Oxoglutarate (alpha-ketoglutarate) receptor 1 BAO_0200257 A rhodopsin-like G protein-coupled receptor that is a translation product of the P2RY8 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB, UniProtKB:Q86VZ1] MGC50878 P2Y8 P2RY8 PRO:000001542 P2Y purinoceptor 8 BAO_0200258 A P2RY10-like receptor that is a translation product of the P2RY10 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] P2Y10 P2RY10 PRO:000001652 P2Y purinoceptor 10 BAO_0200259 A rhodopsin-like G protein-coupled receptor that is a translation product of the SUCNR1 gene or a 1:1 ortholog thereof. It is reported to bind succinate. It is currently classed as an orphan receptor. [PRO:WCB] GPR91 SUCNR1 PRO:000001556 Succinate receptor 1 BAO_0200260 A trace amine-associated receptor 1-4 that is a translation product of the TAAR2 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] GPR58 TAAR2 PRO:000001712 Trace amine-associated receptor 2 BAO_0200261 A trace amine-associated receptor 1-4 that is a translation product of the TAAR3 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. The human protein is expressed but is probably not functional due to a frameshift mutation. [PRO:WCB, UniProtKB:Q9P1P4] GPR57 GPR58 TAAR2 TAAR3 PRO:000001713 Trace amine-associated receptor 3 BAO_0200263 A trace amine-associated receptor-related protein that is a translation product of the TAAR5 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] MGC138414 MGC138416 PNR RP11-295F4.5 TAAR5 PRO:000001679 Trace amine-associated receptor 5 BAO_0200264 A trace amine-associated receptor 6-9 that is a translation product of the TAAR6 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] RP11-295F4.3 TA4 TAR4 TAR6 TRAR4 TAAR6 PRO:000001715 Trace amine-associated receptor 6 BAO_0200265 A trace amine-associated receptor 6-9 that is a translation product of the human TAAR8 gene or a 1:1 ortholog thereof. [PRO:WCB] GPR102 TA5 TAR5 TRAR5 TaR-5 TaR-8 TAAR8 PRO:000001717 Trace amine-associated receptor 8 BAO_0200266 A trace amine-associated receptor 6-9 that is a translation product of the TAAR9 gene or a 1:1 ortholog thereof. It is currently classed as an orphan receptor. [PRO:WCB] TA3 TAR3 TAR9 TRAR3 TAAR9 PRO:000001718 Trace amine-associated receptor 9 BAO_0200267 A chemokine receptor that is a translation product of the CCBP2 gene or a 1:1 ortholog thereof. The preferred ligands may be CCL2, CCL3, CCL5, CCL7. The signaling pathway is not known. [PMID:9405404, PRO:WCB] CCR10 CCR9 CMKBR9 D6 MGC126678 MGC138250 hD6 CCPB2 PRO:000001215 Chemokine-binding protein 2 BAO_0200268 A chemokine receptor that is a translation product of the CCRL1 gene or a 1:1 ortholog thereof. The preferred ligands may be CCL19, CCL21, CCL25. This is a non-signaling chemokine receptor. [PRO:WCB] CC-CKR-11 CCBP2 CCR-11 CCR10 CCR11 CCX CKR CCX-CKR CCRL1 PRO:000001213 C-C chemokine receptor type 11 BAO_0200269 A rhodopsin-like G protein-coupled receptor that is a translation product of the DARC gene or a 1:1 ortholog thereof. This is a non-specific, non-signaling chemokine receptor. [PRO:WCB] CCBP1 CD234 Dfy FY GPD GpFy WBCQ1 FY PRO:000001132 Duffy antigen/chemokine receptor BAO_0200270 A protein that is a translation product of the CALCR gene or a 1:1 ortholog thereof. [PRO:DNx] CRT CT-R CTR CTR1 CT PRO:000004972 Calcitonin receptor BAO_0200271 A protein that is a translation product of the CRHR1 gene or a 1:1 ortholog thereof. [PRO:DNx] CRF-R CRF1 CRFR1 CRH-R1h CRHR CRHR1L CRHR1f CRF1 PRO:000005869 Corticotropin-releasing factor receptor 1 BAO_0200272 A protein that is a translation product of the CRHR2 gene or a 1:1 ortholog thereof. [PRO:DNx] CRFR2 CRF2 PRO:000005870 Corticotropin-releasing factor receptor 2 BAO_0200273 A protein that is a translation product of the GIPR gene or a 1:1 ortholog thereof. [PRO:DNx] MGC126722 PGQTL2 GIP PRO:000007988 Gastric inhibitory polypeptide receptor BAO_0200274 A protein that is a translation product of the GLP1R gene or a 1:1 ortholog thereof. [PRO:DNx] GLP1R MGC138331 GLP-1 PRO:000008040 Glucagon-like peptide 1 receptor BAO_0200275 A protein that is a translation product of the GLP2R gene or a 1:1 ortholog thereof. [PRO:DNx] GLP2R GLP-2 PRO:000008041 Glucagon-like peptide 2 receptor BAO_0200276 A protein that is a translation product of the SCTR gene or a 1:1 ortholog thereof. [PRO:DNx] SR SCTR secretin PRO:000014544 Secretin receptor BAO_0200277 A protein that is a translation product of the PTH1R gene or a 1:1 ortholog thereof. [PRO:DNx] MGC138426 MGC138452 PFE PTHR PTHR1 PTH1 PRO:000013430 Parathyroid hormone receptor 1 BAO_0200278 A protein that is a translation product of the PTH2R gene or a 1:1 ortholog thereof. [PRO:DNx] PTHR2 PTH2 PRO:000013432 Parathyroid hormone receptor 2 BAO_0200279 A protein that is a translation product of the ADCYAP1R1 gene or a 1:1 ortholog thereof. [PRO:DNx] PAC1 PACAPR PACAPRI PAC1 PRO:000003762 Pituitary adenylate cyclase-activating polypeptide type I receptor BAO_0200280 A protein that is a translation product of the VIPR1 gene or a 1:1 ortholog thereof. [PRO:DNx] FLJ41949 HVR1 II PACAP-R-2 RDC1 V1RG VAPC1 VPAC1 PRO:000017300 Vasoactive intestinal polypeptide receptor 1 BAO_0200281 A protein that is a translation product of the VIPR2 gene or a 1:1 ortholog thereof. [PRO:DNx] FLJ16511 VPAC2 VPCAP2R VPAC2 PRO:000017301 Vasoactive intestinal polypeptide receptor 2 BAO_0200282 A protein that is a translation product of the BAI1 gene or a 1:1 ortholog thereof. [PRO:DNx] BAI1 FLJ41988 GDAIF BAI1 PRO:000004629 Brain-specific angiogenesis inhibitor 1 BAO_0200283 A 5-hydroxytryptamine receptor 5 that is a translation product of the mouse Htr5b gene or a 1:1 ortholog thereof. [PRO:WCB] GPR134 HTR5B 5-HT5B PRO:000001170 5-Hydroxytryptamine receptor 5B BAO_0200284 A type of receptor which facilitates the sensation of taste. Taste receptor BAO_0200285 A protein that is a translation product of the TAS1R1 gene or a 1:1 ortholog thereof. [PRO:DNx] GPR70 TR1 PRO:000016060 Taste receptor type 1 member 1 BAO_0200286 A protein that is a translation product of the TAS1R2 gene or a 1:1 ortholog thereof. [PRO:DNx] GPR71 TR2 PRO:000016061 Taste receptor type 1 member 2 BAO_0200287 A protein that is a translation product of the TAS1R3 gene or a 1:1 ortholog thereof. [PRO:DNx] TAS1R3 TR3 PRO:000016062 Taste receptor type 1 member 3 BAO_0200288 A protein that is a translation product of the GABBR2 gene or a 1:1 ortholog thereof. [PRO:DNx] FLJ36928 GABABR2 GPR51 GPRC3B HG20 HRIHFB2099 GABAB2 PRO:000007762 GABAB receptor 2 BAO_0200290 A protein that is a translation product of the GPRC5A gene or a 1:1 ortholog thereof. [PRO:DNx] GPRC5A RAI3 RAIG1 RAIG1 PRO:000008194 GPCR family C group 5 member A BAO_0200303 Cholecystokinin receptors or CCK receptors are a group of G protein-coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK functions in stimulation of bicarb secretion, gall bladder emptying and inhibiting gut motility. Gasrin functions in regulation of nociception, anxiety, memory and hunger. Cholecystokinin receptor BAO_0200304 Dopamine receptors are a class of metabotropic G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors. Dopamine receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling. Abnormal dopamine receptor signaling and dopaminergic nerve function is implicated in several neuropsychiatric disorders. Thus, dopamine receptors are common neurologic drug targets; antipsychotics are often dopamine receptor antagonists while psychostimulants are typically indirect agonists of dopamine receptors. Dopamine receptor BAO_0200305 There are at least three known endothelin receptors, ETA, ETB1 and ETB2, all of which are G protein-coupled receptors whose activation result in elevation of intracellular-free calcium. Endothelin receptor BAO_0200306 A rhodopsin-like G protein-coupled receptor 1 that is a translation product of the GPER gene or a 1:1 ortholog thereof. The preferred ligand is estrogen." [PRO:WCB] GPER GPR30 GPER PRO:000001111 Estrogen (G protein-coupled) receptor BAO_0200307 The formyl peptide receptors (FPR) are a members of a class of G protein-coupled receptors involved in chemotaxis. These receptors where originally identified by their ability to bind N-formyl peptides such as N-formylmethionine produced by the degradation of either bacterial or host cells. Hence formyl peptide receptors are involved in mediating immune cell response to infection. These receptors may also act to suppress the immune system under certain conditions. The close phylogenetical relation of signaling in chemotaxis and olfaction was recently proved by detection formyl peptide receptor like proteins as a distinct family of vomeronasal organ chemosensors in mice. Formyl peptide receptor BAO_0200309 The galanin receptor is a G protein-coupled receptor, or metabotropic receptor which binds galanin. Galanin receptors can be found throughout the peripheral and central nervous systems and the endocrine system. Galanin receptor BAO_0200310 Growth hormone secretagogue receptor is a G protein-coupled receptor that binds ghrelin and plays a role in energy homeostasis and regulation of body weight. GHSR GHSR PRO:000001225 Ghrelin receptor BAO_0200312 This receptor is a member of the seven-transmembrane, G protein-coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Gonadotrophin-releasing hormone receptor and putative receptor BAO_0200320 Motilin receptor is a G protein-coupled receptor that binds motilin. Motilin in turn is an intestinal peptide that stimulates contraction of gut smooth muscle. A growth hormone secretagogue/motilin receptor that is a translation product of the MLNR gene or a 1:1 ortholog thereof. The preferred ligand is motilin, an intestinal peptide that stimulates contraction of gut smooth muscle. [PRO:WCB, Wikipedia:Motilin_receptor] GPR38 MLNR MTLR MTLR PRO:000001240 Motilin receptor BAO_0200326 Neurotensin receptors belong to the large superfamily of G protein-coupled receptors. NTSR mediate the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. Neurotensin receptor BAO_0200328 Opioid receptors are a group of G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. The opioid receptors are ~40% identical to somatostatin receptors (SSTRs). Opiate receptors are distributed widely in the brain, and are found in the spinal cord and digestive tract. Major function involves modulation of analgesia, sedation, physical dependence, antidepressant effects, miosis, dysphoria, respiratory depression, euphoria, GI motility, as well as tolerance and appetite. Opioid receptor BAO_0200329 The orexin receptor (also referred to as the hypocretin receptor) is a G protein-coupled receptor that binds the neuropeptide hormone orexin. The orexin/hypocretin system was initially suggested to be primarily involved in the stimulation of food intake, based on the finding that central administration of orexin A/hypocretin-1 increases food intake. In addition, it stimulates wakefulness and energy expenditure. Orexin receptor BAO_0200330 P2Y receptors are a family of purinergic receptors, G protein-coupled receptors stimulated by nucleotides such as ATP, ADP, UTP, UDP and UDP-glucose. To date, 12 P2Y receptors have been cloned in humans: P2Y1, P2Y2, P2Y4, P2Y5, P2Y6, P2Y8, P2Y9 (present in NCBI as GPR23), P2Y10, P2Y11, P2Y12, P2Y13 and P2Y14. P2Y receptors are present in almost all human tissues where they exert various biological functions based on their G protein coupling. P2Y purinoceptor BAO_0200331 Pyroglutamylated RFamide peptide receptor also known as orexigenic neuropeptide QRFP receptor or G protein-coupled receptor 103 (GPR103) is a protein that in humans is encoded by the QRFPR gene. A 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain. The 43-amino acid QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of aldosterone, suggesting that QRFP and GPR103 regulate adrenal function. QRFPR GPR103 QRFPR PRO:000001498 Orexigenic neuropeptide QRFP receptor Pyroglutamylated RFamide peptide receptor BAO_0200332 The platelet-activating factor receptor is a G protein-coupled receptor which binds platelet-activating factor. The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes. PAFR PAFR PRO:000001501 Platelet-activating factor receptor BAO_0200333 Prokineticin receptor 1, also known as PKR1, is a human protein encoded by the PROKR1 gene. Prokineticin receptor BAO_0200334 The prolactin-releasing hormone receptor is a G protein-coupled receptor that binds the prolactin releasing hormone. PRLHR is a 7-transmembrane domain receptor for prolactin-releasing hormone that is highly expressed in anterior pituitary (Ozawa et al., 2002). PRLHR GPR10 PRLHR PRO:000001546 Prolactin-releasing peptide receptor BAO_0200340 The thyrotropin-releasing hormone receptor (TRHR) is a G protein-coupled receptor which binds the tripeptide thyrotropin releasing hormone. The TRHR are found in the brain and when bound by TRH result act through phospholipase C to increase intracellular inositol trisphosphate. TRH stimulates the release of thyroid-stimulating hormone and prolactin by the anterior pituitary. TRHR TRHR PRO:000001557 Thyrotropin-releasing hormone receptor BAO_0200341 A trace amine-associated receptor 1-4 that is a translation product of the TAAR1 gene or a 1:1 ortholog thereof. The preferred ligands of the human protein are trace amines, including beta-phenylethylamine, p-tyramine, octopamine and tryptamine. It is unresponsive to amines such as epinephrine and histamine and only partially activated by dopamine and serotonin. [PRO:WCB, UniProtKB:Q96RJ0] TAAR1 TAAR1 PRO:000001711 Trace amine-associated receptor 1 BAO_0200342 A G protein-coupled receptor which binds the peptide hormone urotensin-II. Urotensin-II (U-II) is a peptide ligand, initially isolated from the neurosecretory system of the Goby fish. It produces slow relaxation of mouse annococygeus muscle, in addition to contraction of rat artery segments. In 1998, the cDNA encoding a U-II precursor was cloned in humans, unequivocally demonstrating its existence in mammalian species. UTS2R UTS2R PRO:000001561 Urotensin-2 receptor BAO_0200343 Class A GPCR that binds vasopressin. AVPR1A are expressed in vascular smooth muscle cells, hepatocytes, platelets, brain cells, and uterus cells. (vasocontriction) AVPR1B are expressed in cells of the anterior pituitary and throughout the brain, especially in the pyramidal neurons of the hippocampal CA2 field. (neural functions) AVPR2 are expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, in fetal lung tissue and lung cancer, the last two being associated with alternative splicing. (antidiuretic function) AVPR2 is also expressed in the liver where stimulation releases a variety of clotting factors into the bloodstream. In the kidney, AVPR2's primary function is to respond to arginine vasopressin by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of AVPR2 is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results Vasopressin and oxytocin receptor BAO_0200344 An orphan receptor of Class A is an apparent receptor that has a similar structure to other identified receptors but whose endogenous ligand has not yet been identified. Class A Orphan BAO_0200345 A group of receptors including chemokine binding protein 2, chemokine (C-C motif) receptor-like 1, and Duffy blood group, chemokine receptor. Non-signalling 7TM chemokine-binding protein BAO_0200346 The calcium-sensing receptors sense extracellular levels of calcium ion. In the parathyroid gland, the calcium-sensing receptor controls calcium homeostasis by regulating the release of parathyroid hormone (PTH). Calcium-sensing receptor-related BAO_0200347 The calcitonin receptor (CT) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in maintenance of calcium homeostasis, particularly with respect to bone formation and metabolism. Calcitonin receptor and Calcitonin receptor-like BAO_0200355 The metabotropic glutamate receptors, or mGluRs, are a type of glutamate receptor that are active through an indirect metabotropic process. Metabotropic glutamate receptor BAO_0200356 An orphan receptor of Class C is an apparent receptor that has a similar structure to other identified receptors but whose endogenous ligand has not yet been identified. Class C Orphan BAO_0200357 The protein encoded by the CALCRL gene is a G protein-coupled receptor related to the calcitonin receptor. CALCRL is linked to one of three single transmembrane domain receptor activity-modifying proteins (RAMPs) that are essential for functional activity. The association of CALCRL with different RAMP proteins produces different receptors: with RAMP1: produces a CGRP receptor with RAMP2: produces an adrenomedullin (AM) receptor, designated AM1 with RAMP3: produces a dual CGRP/AM receptor designated AM2 These receptors are linked to the G protein Gs, which activates adenylate cyclase and activation results in the generation of intracellular cyclic adenosine monophosphate (cAMP). CALCRL CALCRL PRO:000004973 Calcitonin receptor-like BAO_0200358 A protein that is a translation product of the GHRHR gene or a 1:1 ortholog thereof. [PRO:DNx] A receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010] GHRHR GHRHR PRO:000007972 Growth hormone releasing hormone receptor BAO_0200359 A protein that is a translation product of the GCGR gene or a 1:1 ortholog thereof. [PRO:DNx] FLJ97182 GGR MGC138246 GCCR glucagon PRO:000007892 Glucagon receptor BAO_0200360 A protein that is a translation product of the BAI2 gene or a 1:1 ortholog thereof. [PRO:DNx] BAI2 BAI2 PRO:000004630 Brain-specific angiogenesis inhibitor 2 BAO_0200361 A protein that is a translation product of the BAI3 gene or a 1:1 ortholog thereof. [PRO:DNx] BAI3 BAI3 PRO:000004631 Brain-specific angiogenesis inhibitor 3 BAO_0200362 A protein that is a translation product of the CD97 gene or a 1:1 ortholog thereof. [PRO:WCB] TM7LN1 CD97 PRO:000001311 CD97 molecule BAO_0200363 A protein that is a translation product of the CELSR1 gene or a 1:1 ortholog thereof. [PRO:DNx] CDHF9 DKFZp434P0729 FMI2 HFMI2 ME2 CELSR1 PRO:000005318 Cadherin EGF LAG seven-pass G-type receptor 1 BAO_0200364 A protein that is a translation product of the CELSR2 gene or a 1:1 ortholog thereof. [PRO:DNx] CDHF10 EGFL2 FLJ34118 FLJ42737 FLJ45143 FLJ45845 Flamingo1 CELSR2 PRO:000005319 Cadherin EGF LAG seven-pass G-type receptor 2 BAO_0200365 A protein that is a translation product of the CELSR3 gene or a 1:1 ortholog thereof. [PRO:DNx] CDHF11 EGFL1 FMI1 HFMI1 MEGF2 RESDA1 CELSR3 PRO:000005320 Cadherin EGF LAG seven-pass G-type receptor 3 BAO_0200366 A protein that is a translation product of the ELTD1 gene or a 1:1 ortholog thereof. [PRO:DNx] ETL KPG_003 ELTD1 PRO:000007047 EGF, latrophilin and seven transmembrane domain containing 1 BAO_0200367 A protein that is a translation product of the EMR1 gene or a 1:1 ortholog thereof. [PRO:WCB] EMR1 TM7LN3 EMR1 PRO:000001813 Egf-like module containing, mucin-like, hormone receptor-like 1 BAO_0200368 A protein that is a translation product of the EMR2 gene or a 1:1 ortholog thereof. [PRO:DNx] CD312 DKFZp781B135 EMR2 EMR2 PRO:000007065 Egf-like module containing, mucin-like, hormone receptor-like 2 BAO_0200369 A protein that is a translation product of the EMR3 gene or a 1:1 ortholog thereof. [PRO:DNx] EMR3 EMR3 PRO:000007066 Egf-like module containing, mucin-like, hormone receptor-like 3 BAO_0200371 A protein that is a translation product of the GPR56 gene or a 1:1 ortholog thereof. [PRO:DNx] BFPP DKFZp781L1398 TM7LN4 TM7XN1 GPR56 PRO:000008189 G protein-coupled receptor 56 BAO_0200372 A protein that is a translation product of the GPR64 gene or a 1:1 ortholog thereof. [PRO:DNx] EDDM6 FLJ00282 HE6 MGC104454 MGC138738 MGC138739 TM7LN2 GPR64 PRO:000008190 G protein-coupled receptor 64 BAO_0200374 A protein that is a translation product of the GPR98 gene or a 1:1 ortholog thereof. [PRO:DNx] DKFZp761P0710 FEB4 KIAA0686 MASS1 USH2B USH2C VLGR1 GPR98 PRO:000008191 G protein-coupled receptor 98 BAO_0200382 Probable G protein-coupled receptor 123 is a protein that in humans is encoded by the GPR123 gene. It is a member of the adhesion-GPCR family of receptors. Family members are normally characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. [PRO:WCB] FLJ25875 FLJ37356 GPR123 PRO:000001147 G protein-coupled receptor 123 BAO_0200388 A protein that is a translation product of the GPR143 gene or a 1:1 ortholog thereof. [PRO:DNx] NYS6 OA1 GPR143 PRO:000008186 G protein-coupled receptor 143 BAO_0200390 A protein that is a translation product of the GPR157 gene or a 1:1 ortholog thereof. [PRO:WCB] FLJ12132 GPR157 PRO:000001149 G protein-coupled receptor 157 BAO_0200391 A calcium-independent alpha-latrotoxin receptor type that is a translation product of the LPHN2 gene or a 1:1 ortholog thereof. [PRO:CNA] CIRL2 CL2 LEC1 LPHH1 LPHN2 PRO:000001234 Latrophilin 2 BAO_0200392 A calcium-independent alpha-latrotoxin receptor that is a translation product of the LPHN3 gene or a 1:1 ortholog thereof. [PRO:CNA] CIRL3 LEC3 LPHN3 PRO:000001235 Latrophilin 3 BAO_0200393 A protein that is a translation product of the CASR gene or a 1:1 ortholog thereof. [PRO:DNx] CAR EIG8 FHH FIH GPRC2A HHC HHC1 CaS PRO:000005058 Calcium-sensing receptor BAO_0200394 A protein that is a translation product of the GPRC6A gene or a 1:1 ortholog thereof. [PRO:DNx] GPCR bA86F4.3 GPRC6 PRO:000008198 GPCR family C group 6 member A BAO_0200395 A protein that is a translation product of the GABBR1 gene or a 1:1 ortholog thereof. [PRO:DNx] FLJ92613 GABABR1 GABBR1-3 GB1 GPRC3A dJ271M21.1.1 dJ271M21.1.2 GABAB1 PRO:000007761 GABAB receptor 1 BAO_0200397 A protein that is a translation product of the GRM1 gene or a 1:1 ortholog thereof. [PRO:DNx] GPRC1A GRM1A MGLUR1 MGLUR1A mGlu1 mGlu1 PRO:000008263 Metabotropic glutamate receptor 1 BAO_0200398 A protein that is a translation product of the GRM2 gene or a 1:1 ortholog thereof. [PRO:DNx] GLUR2 GPRC1B MGLUR2 mGlu2 mGlu2 PRO:000008264 Metabotropic glutamate receptor 2 BAO_0200399 A protein that is a translation product of the GRM3 gene or a 1:1 ortholog thereof. [PRO:DNx] GLUR3 GPRC1C MGLUR3 mGlu3 mGlu3 PRO:000008265 Metabotropic glutamate receptor 3 BAO_0200400 A protein that is a translation product of the GRM4 gene or a 1:1 ortholog thereof. [PRO:DNx] GPRC1D MGC177594 MGLUR4 mGlu4 mGlu4 PRO:000008266 Metabotropic glutamate receptor 4 BAO_0200401 A protein that is a translation product of the GRM5 gene or a 1:1 ortholog thereof. [PRO:DNx] GPRC1E MGLUR5 mGlu5 mGlu5 PRO:000008267 Metabotropic glutamate receptor 5 BAO_0200402 A protein that is a translation product of the GRM6 gene or a 1:1 ortholog thereof. [PRO:DNx] CSNB1B DKFZp686H1993 GPRC1F MGLUR6 mGlu6 mGlu6 PRO:000008268 Metabotropic glutamate receptor 6 BAO_0200403 A protein that is a translation product of the GRM7 gene or a 1:1 ortholog thereof. [PRO:DNx] FLJ40498 GLUR7 GPRC1G MGLU7 MGLUR7 mGlu7 PRO:000008269 Metabotropic glutamate receptor 7 BAO_0200404 A protein that is a translation product of the GRM8 gene or a 1:1 ortholog thereof. [PRO:DNx] FLJ41058 GLUR8 GPRC1H MGC126724 MGLUR8 mGlu8 mGlu8 PRO:000008270 Metabotropic glutamate receptor 8 BAO_0200432 Amines are organic compounds and functional groups that contain a basic nitrogen atom with a lone pair. dopamine, epinephrine, norepinephrine, histamine, glutamate (metabotropic effect), glucagon, acetylcholine (muscarinic effect), and serotonin Amine BAO_0200433 The Gs alpha subunit (or Gs protein) is a heterotrimeric G protein subunit that activates the cAMP-dependent pathway by activating adenylate cyclase. alpha s BAO_0200435 The Gao family is homologous to the Gai family. Both Gao and Gai can often bind to the same G protein-coupled receptors (GPCRs) but have different effectors. The downstream effectors of Go are much less understood compared with the effectors of Gi, which inhibit adenylyl cyclases. Gai is the alpha subunit of the heterotrimeric guanine nucleotide-binding protein (G protein) holoenzyme Gi. It inhibits adenylyl cyclase and thereby decreases cellular adenosine 3',5'-monophosphate (cAMP) levels. alpha i/o BAO_0200436 G12/G13 subunits are alpha units of heterotrimeric G proteins that regulate cell processes through the use of guanine nucleotide exchange factors. They are not sensitive to pertussis toxin. G proteins G12 and G13 regulate actin cytoskeletal remodeling in cells. G13 is also essential for receptor tyrosine kinase-induced migration of fibroblast and endothelial cells. alpha 12/13 BAO_0200437 Voltage-dependent calcium channels (VDCC) are a group of voltage-gated ion channels found in excitable cells (e.g., muscle, glial cells, neurons, etc.) with a permeability to the ion Ca2+. These channels are slightly permeable to sodium ions, so they are also called Ca2+-Na+ channels, but their permeability to calcium is about 1000-fold greater than to sodium under normal physiological conditions. At physiologic or resting membrane potential, VDCCs are normally closed. They are activated (i.e., opened) at depolarized membrane potentials and this is the source of the "voltage-dependent" epithet. Activation of particular VDCCs allows Ca2+ entry into the cell, which, depending on the cell type, results in muscular contraction, excitation of neurons, up-regulation of gene expression, or release of hormones or neurotransmitters. Voltage dependent calcium channel BAO_0200439 The visual system is the part of the central nervous system which enables organisms to process visual detail, as well as enabling several non-image forming photoresponse functions. It interprets information from visible light to build a representation of the surrounding world. The visual system accomplishes a number of complex tasks, including the reception of light and the formation of monocular representations; the construction of a binocular perception from a pair of two dimensional projections; the identification and categorization of visual objects; assessing distances to and between objects; and guiding body movements in relation to visual objects. Visual sensation BAO_0200440 A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell. It functions as an "on" or "off" switch in many cellular functions. The phosphate group is attached to the amino acid tyrosine on the protein. Tyrosine kinases are a subgroup of the larger class of protein kinases which attach phosphate groups to other amino acids (serine and threonine). Phosphorylation of proteins by kinases is an important mechanism in communicating signals within a cell (signal transduction) and regulating cellular activity, such as cell division. Tyr protein kinase BAO_0200441 Tubulin is one of several members of a small family of globular proteins. The most common members of the tubulin family are α-tubulin and β-tubulin, the proteins that make up microtubules. Each has a molecular weight of approximately 55 kiloDaltons. Microtubules are assembled from dimers of α- and β-tubulin. Tubulin BAO_0200442 WD-repeat-containing proteins are those that contain 4 or more copies of the WD-repeat (tryptophan-aspartate repeat), a sequence motif approximately 31 amino acids long, that encodes a structural repeat. Trp Repeat protein BAO_0200443 Tolerance is said to develop when the response to the same dose of a drug decreases with repeated use. Dependence is a physiological state of adaptation to a drug. Tolerance and dependence BAO_0200444 Ensemble of cells from the same origin that together carry out a specific function (tissue). placeholder Tissue BAO_0200445 Thermoregulation is the ability of an organism to keep its body temperature within certain boundaries, even when the surrounding temperature is very different. Thermoregulation BAO_0200472 A phosphodiesterase is any enzyme that breaks a phosphodiester bond (a group of strong covalent bonds between a phosphate group and two 5-carbon ring carbohydrates (pentoses) over two ester bonds). Phosphodiesterase BAO_0200475 Phosphatidylinositol 3-kinases (PI 3-kinases or PI3Ks) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. PI3 kinase definition xref