Represents diagnostic procedures, laboratory tests, or other procedures whereby an event or diagnosis was evaluated. For instance, most hemorrhagic strokes would be evaluated by CT scan or MRI. Unit of measurement attribute for laboratory evaluations. Used when specifying the physical dimensions of a class - e.g., the diameter of a bruise. BPO:AMICAR BPO:RU_questionnaire_metadata Contains concepts that pertain specifically to the Rockefeller University Bleeding History Phenotyping System (BHPS), http://ds9.rockefeller.edu/RUBHPSR/ BPO:abdominal_muscle BPO:abdominal_striae BPO:abnormal_connective_tissue BPO:abnormal_migration Abnormal migration of VWF multimers on medium-resolution gels is abnormal. BPO:abnormal_separation VWF multimers that separate into triplets or quintuplets on medium-resolution are abnormal. BPO:abo_blood_type The interpretation of some hematologic evaluations is influenced by ABO blood type. BPO:abortion BPO:absent BPO:activated_partial_thromboplastin_time Activated partial thromboplastin time (aPTT) is a measure of the intrinsic pathway of the coagulation cascade, measured in seconds. UMLS ID: 694 C0030605:Activated Partial Thromboplastin Time (Activated Partial Thromboplastin Time measurement) [Laboratory Procedure] reference url: http://en.wikipedia.org/wiki/Partial_thromboplastin_time BPO:acuity differs from age of onset - e.g., postpartum bleeding timing could be 1 week, 2 weeks, 4 weeks after delivery of infant... BPO:acute BPO:adulthood BPO:african_american BPO:age BPO:age_at_diagnosis BPO:age_at_event BPO:age_of_cessation BPO:age_of_maximum_severity BPO:age_of_onset BPO:anatomic_location BPO:ancillary_medication BPO:ancillary_treatment Treatments related to bleeding (e.g., iron for anemia, antibiotics to treat bacterial infection cauging hemoptysis, or radiation therapy causing cessation of menses) BPO:anesthesia BPO:anesthetic_gas BPO:angiodysplasia BPO:angioma BPO:ankle BPO:answer_id BPO:antibiotics e.g., to treat underlying infection causing bleeding BPO:anticoagulant_or_antiplatelet_medication BPO:antifibrinolytic BPO:anus BPO:arm BPO:asian BPO:aspirin BPO:assessment BPO:ativene_packing BPO:aunt BPO:autoimmune_disorder BPO:average_duration BPO:average_event_severity BPO:average_frequency BPO:avoidance BPO:back BPO:bacterial_infection BPO:bandage 0 56 BPO:bat_score BPO:behavioral_modification BPO:bladder BPO:bladder_disease 1 BPO:blade_razor_shaving BPO:bleeding BPO:bleeding_after_abortion BPO:bleeding_at_delivery Is treatment_administered really different from (generic_bleeding or uterine_...)? Represent different questions, but one may be equivalent... BPO:bleeding_disorder 0 BPO:bleeding_during_pregnancy BPO:bleeding_during_procedure BPO:bleeding_score BPO:bleeding_through_protection_product BPO:bleeding_time Bleeding time is the time between the infliction of a small standard cut and the moment at which the bleeding stops, measured in minutes. Reference url: http://en.wikipedia.org/wiki/Bleeding_time UMLS ID: 645 C0005729:Bleeding Time (Bleeding time procedure) [Laboratory Procedure] BPO:bloody_stool Hematochezia Am I using "only" correctly? 0 BPO:body_piercing BPO:body_piercing_bleeding BPO:brain BPO:bronchiectasis BPO:bronchitis BPO:bronchoscopy BPO:bronchus BPO:brother 1 BPO:bruise BPO:bullet_wound BPO:burr_hole Surgical decompression of cranium BPO:caesarian_section BPO:calculated Example: grams per deciliter Units of measurement that are derived by calculation from other units, expressed as a ratio (i.e., mg/mL) BPO:canine BPO:caucasian BPO:cautery BPO:cells_per_mm_cubed BPO:central_nervous_system_bleeding BPO:central_nervous_system_subdivision BPO:central_obesity 0 BPO:cephalohematoma BPO:cerebral_aneurysm BPO:chemotherapy BPO:chest_subdivision BPO:childhood BPO:chronic BPO:circumcision 0 BPO:circumcision_bleeding BPO:cirrhosis BPO:clopidogrel BPO:coagulation_evaluation A coagulation evaluation is a hematologic evaluation pertaining the blood clotting factors. BPO:coagulopathy_of_cirrhosis BPO:coagulopathy_of_kidney_disease BPO:coca-cola BPO:colon BPO:colon_polyp BPO:colonoscopy BPO:color_change BPO:conjunctiva BPO:consecutive BPO:corticosteroid BPO:coumadin BPO:cryoprecipitate BPO:ct_scan BPO:current_frequency BPO:current_status What is the current status of the symptom? Has the symptom resolved, or is it ongoing? BPO:currently_using_medication BPO:cushings_syndrome 1 1 0 BPO:cutaneous_bleeding BPO:cutaneous_finding BPO:cystoscopy BPO:dark_stool Melena BPO:daughter BPO:deciduous BPO:delayed BPO:delayed_discharge_or_readmission BPO:delayed_onset_bleeding BPO:delivery BPO:demographic_characteristics BPO:densitometric Densinometric analysis of VWF multimers classifies multimers into small (1-5 oligomers), intermediate (6-10 oligomers), and large (>10 oligomers) multimers BPO:desmopressin BPO:desmopressin_injection BPO:desmopressin_nasal BPO:diagnostic_procedure BPO:diffuse BPO:dilatation_and_curettage BPO:disease_or_disorder BPO:diverticular_disease BPO:double_jointedness BPO:duodenal_ulcer BPO:duration BPO:duration_between_events BPO:duration_trend BPO:ear BPO:elbow BPO:electric_razor_shaving BPO:emphysema BPO:endoscopic_intervention 0 1 1 0 BPO:epistaxis BPO:epistaxis_treatment BPO:erythrocyte_evaluation An erythrocyte evaluation is a hematologic evaluation pertaining to erythrocytes (a.k.a., "red blood cells") BPO:esophageal_disease BPO:esophageal_tear BPO:esophageal_varix BPO:esophagus BPO:ethnicity BPO:event BPO:event_age BPO:event_attribute BPO:event_sequence BPO:ever_used_medication BPO:exam_under_anesthesia BPO:excessive BPO:exposed_or_unexposed_location TO DO: This class needs a better name; will also require clearer annotation BPO:eye_subdivision BPO:eyebrow BPO:fL BPO:face_subdivision BPO:factor_IX_deficiency BPO:factor_VIII_deficiency BPO:factor_VII_deficiency BPO:factor_V_deficiency BPO:factor_XIII_deficiency BPO:factor_XI_deficiency BPO:factor_X_deficiency BPO:factor_ix Reference url: http://en.wikipedia.org/wiki/Factor_IX UMLS ID: 1000 C0200408:Factor IX level (Coagulation factor IX measurement) [Laboratory Procedure] BPO:factor_replacement BPO:factor_viii Reference url: http://en.wikipedia.org/wiki/Factor_viii UMLS ID: 1000 C0200399:factor VIII level (Clotting factor VIII assay) [Laboratory Procedure] BPO:factor_xi Reference url: http://en.wikipedia.org/wiki/Factor_xi UMLS ID: 1000 C0200410:factor XI level (Clotting factor XI assay) [Laboratory Procedure] BPO:farm_injury BPO:father BPO:female BPO:fibrin_glue BPO:flooding BPO:fragile_scars BPO:frequency BPO:frequency_trend BPO:fresh_frozen_plasma BPO:fungal_infection BPO:g_per_L BPO:g_per_dL BPO:gastric_ulcer BPO:gastritis 1 0 0 0 BPO:gastrointestinal_bleeding BPO:gastrointestinal_bleeding_treatment BPO:gastrointestinal_disorder BPO:gastrointestinal_malignancy BPO:gastrointestinal_neoplasm BPO:gastrointestinal_organ BPO:gauze_packing BPO:generic_bleeding_treatment BPO:genital BPO:glass_wound BPO:gum_bleeding BPO:gums BPO:gynecologic_disorder BPO:hair_removal BPO:head_subdivision BPO:healthcare_professional Healthcare professional refers to a physician or other professional who has provided treatment to the subject; as in the question "In the opinion of the healthcare professional who treated you, was your bleeding excessive?" BPO:healthcare_professional_assessment BPO:heart BPO:heavier_menses_than_other_women BPO:heavy_flow AGAIN : can't enter duration property BPO:hemarthrosis 0 BPO:hematemesis BPO:hematochezia BPO:hematocrit Reference url: http://en.wikipedia.org/wiki/Hematocrit The hematocrit is the proportion of blood that is made up of red blood cells (by volume). UMLS ID: 694 C0018935:Haematocrit (Hematocrit procedure) [Laboratory Procedure] BPO:hematologic_evaluation A hematologic evaluation is a laboratory evaluation pertaining to the hematologic system, i.e., the blood and blood-producing organs. Hematologic evaluations include assessments of coagulation, erythrocytes, white blood cells, and platelets, but not other bloodborne proteins more pertinent to other organ systems such as albumin, creatinine, etc. 1 1 0 0 BPO:hematuria BPO:hematuria_treatment BPO:hemoglobin Reference url: http://en.wikipedia.org/wiki/Hemoglobin UMLS ID: 1000 C0518015:haemoglobin test (Hemoglobin measurement) [Laboratory Procedure] 0 BPO:hemoptysis confounded_by instead of has_predisposition???? 0 BPO:hemorrhagic_stroke BPO:hemorrhoids BPO:heparin BPO:high_resolution_gel BPO:hip BPO:hispanic BPO:horizontal_location BPO:hormonal_therapy BPO:hormone_replacement_therapy BPO:horseback_injury BPO:hyperactive BPO:hysterectomy_treatment BPO:ice BPO:immediate_treatment BPO:immune_thrombocytopenia BPO:incisor BPO:induced_delivery BPO:infancy BPO:infection BPO:inflammatory_bowel_disease Is "or" the correct operator? BPO:internal_iliac_artery_ligattion BPO:internal_organ BPO:internal_reproductive_organ BPO:intravenous_anesthesia BPO:iron_injections BPO:iron_pills BPO:iu_per_dL BPO:joint BPO:kidney BPO:kidney_disease BPO:knee BPO:knife_wound BPO:laboratory_evaluation A laboratory evaluation is an investigative procedure performed in a laboratory used to quantify an aspect of human physiology and/or disease. BPO:laboratory_metadata Contains properties common to many laboratory evaluations. BPO:last_event BPO:last_medication_use BPO:least_severe_event BPO:left BPO:leg BPO:lesion_size BPO:limb BPO:limitation_due_to_symptom BPO:lip_bleeding BPO:lips BPO:liver BPO:liver_disease BPO:local_injection BPO:local_pressure BPO:lochia BPO:long_term_treatment BPO:loose_skin BPO:loss_of_hmw_multimers Loss of high molecular weight VWF multimers on low-resolution gels is abnormal. BPO:low_molecular_weight_heparin BPO:low_resolution_gel BPO:lower BPO:lung BPO:major-abdominal BPO:major-gynecology BPO:major-thoracic BPO:male BPO:maternal_grandfather BPO:maternal_grandmother BPO:maximal_treatment treatment that was administered for the most severe event BPO:maximum_duration -3 45 BPO:mcmdm_1_score BPO:mean_corpuscular_volume Reference url: http://en.wikipedia.org/wiki/Mean_corpuscular_volume UMLS ID: 1000 C1948043:mean corpuscular volume (Erythrocyte Mean Corpuscular Volume Measurement) [Laboratory Procedure] BPO:mean_platelet_volume Reference url: http://en.wikipedia.org/wiki/Mean_platelet_volume The mean platelet volume (MPV) is a measurement of the average size of blood platelets. UMLS ID: 1000 C0200665:Mean platelet volume (Platelet mean volume determination) [Laboratory Procedure] BPO:medical_consultation BPO:medication_dosage BPO:medication_frequency BPO:medication_metadata BPO:melena BPO:menorrhagia BPO:menses_finding Event properties that pertain only to heavy menstrual periods 0 1 0 1 BPO:menstrual_bleeding BPO:mg_per_mL BPO:micrometers_cubed BPO:microscopic_blood BPO:million_cells_per_L BPO:minor BPO:minor_cut 1 0 0 BPO:minor_cut_bleeding BPO:minutes BPO:miscarriage BPO:missed_work_or_school BPO:moderate BPO:molar BPO:more_than_one_race BPO:most_common_treatment BPO:most_severe_event BPO:mother BPO:motor_vehicle_accident BPO:mouth_subdivision BPO:mri BPO:multimers_qualitative_abnormal BPO:multimers_qualitative_interpretation VWF multimers may be classified as normal or abnormal on qualitative analysis. BPO:multimers_qualitative_normal BPO:muscle BPO:muscle_hematoma 1 0 0 BPO:musculoskeletal_bleeding BPO:nasal_packing BPO:native_hawaiian_pacific_islander BPO:navel BPO:neck BPO:nephew BPO:neurologic_disorder BPO:neurologic_impairment BPO:neurologic_treatment BPO:niece BPO:nipple BPO:non_steroidal_anti_inflammatory_drug BPO:normal_range Specificies high ranges of various laboratory evaluations. BPO:nose_subdivision BPO:nostril BPO:not_hispanic BPO:nuchal_fat_deposition aka "buffalo hump" BPO:obesity BPO:obstetrical_disorder 0 BPO:ocular_bleeding BPO:ongoing 1 0 1 BPO:oral_cavity_bleeding BPO:oral_contraceptive_pill BPO:oropharynx_surgery Synonym:Nose BPO:other_disease_or_disorder close off classes with anatomic locations BPO:other_hair_removal BPO:other_procedure BPO:other_surgery BPO:other_thrombocytopenia BPO:other_trauma BPO:ovary BPO:ovulation 0 BPO:ovulation_bleeding BPO:packed_red_blood_cells BPO:pad BPO:pain BPO:paternal_grandfather BPO:paternal_grandmother 0 BPO:pbac_score BPO:percent BPO:period_protection_product BPO:permanent 0 BPO:person 0 BPO:petechiae is the sequence of "or" using the right term? BPO:physical_finding BPO:pink BPO:platelet_abnormality BPO:platelet_count Platelet count is the number of platelets per unit of whole blood. Reference url: http://en.wikipedia.org/wiki/Platelet_count#High_and_low_counts UMLS ID: 1000 C0032181:Platelet Count (Platelet Count measurement) [Laboratory Procedure] BPO:platelet_evaluation A platelet evaluation is a hematologic evaluation pertaining to blood platelets. BPO:platelet_function_analyzer_100 Platelet function analyzer-100 (PFA-100) is a test that aspirates blood through a cartridge containing either a) collagen and epinephrine or b) collagen and adenosine diphosphate (ADP). This process induces the formation of a platelet plug; the PFA-100 device records the time required for the platelet plug to form. Reference url: http://en.wikipedia.org/wiki/PFA-100 BPO:platelets 0 BPO:postpartum_bleeding 0 BPO:pregnancy_bleeding BPO:pregnancy_duration Consider just making it trimesters instead??? Is it necessary to even enumerate any responses? 0 BPO:pregnancy_event Need to represent: postnatal, prenatal bleeding episodes; number of pregnancies; pregnancy outcome is enumerated BPO:pregnancy_finding BPO:pregnancy_outcome BPO:presence_of_supranormal_multimers The presence of supranormal VWF multimers on low-resolution gels is abnormal. BPO:present BPO:pressure BPO:pretreatment 0 0 BPO:procedural_and_surgical_bleeding Multiple instances of surgery possible - do we need to modify all asserted conditions to account for multiple possible events? e.g., has_event_number min 0 and has_property some treatment_administered BPO:procedural_intervention BPO:prolonged_bleeding_after_procedure BPO:prothrombin_complex_concentrate BPO:prothrombin_time Prothrombin time (PT) is a test of the extrinsic pathway of the coagulation cascade, measured in seconds. UMLS ID: 812 C0033707:Time, Prothrombin (Prothrombin time assay) [Laboratory Procedure] http://en.wikipedia.org/wiki/Prothrombin_time BPO:pulmonary_disorder BPO:pulmonary_malignancy BPO:pulmonary_organ BPO:qualitative Represents the interpretation of laboratory evaluations whose outcome is judged qualitatively. E.g., Ristocetin induced platelet aggregation may be judged to be "present," "absent," or "hyperactive." BPO:quantitative Represents laboratory evaluations with a quantitative result. E.g., platelet count is expressed in cells/mm^3. BPO:quantity BPO:question_id BPO:race BPO:radiation_therapy BPO:rco_to_ag_ratio VWF:RCo to VWF:Ag ratio is the RCo divided by the Ag. BPO:reason_for_cessation NOTE: I DON'T LIKE THIS CLASS Reason that bleeding stopped... e.g., radiation therapy. BPO:rectum BPO:red BPO:regional_nerve_block BPO:regularity e.g., are periods regular or irregular BPO:relative "Relative" refers to family members of the study subject, e.g., the subject's mother or father. BPO:relative_location BPO:reoperation BPO:resolved BPO:retina BPO:retroorbital_space BPO:right BPO:ripa_qualitative This class represents RIPA results that have been interpreted qualitatively, i.e., as "present," "absent," or "hyperactive." BPO:ripa_qualitative_interpretation BPO:ripa_quantitative This class represents RIPA results that have been interpreted quantitatively, e.g., measured in units of mg per mL. BPO:ristocetin_induced_platelet_aggregation Reference url: http://en.wikipedia.org/wiki/Ristocetin_induced_platelet_agglutination Ristocetin-induced platelet aggregation (RIPA) is a measurement of the amount of platelet aggregation in the presence of ristocetin. RIPA may be reported as a quantitative value, or as a qualitative assessment (present, absent, or hyperactive). BPO:rounded_facies aka "moon facies" BPO:route_of_administration BPO:seasonal_variation for instance, epistaxis is more common during the winter BPO:seconds BPO:section_id BPO:section_score BPO:self_assessment BPO:severe BPO:severity BPO:severity_assessment BPO:severity_temporal_component BPO:sex BPO:shaving BPO:shaving_cut BPO:shaving_cut_bleeding BPO:shaving_cut_treatment BPO:shoulder BPO:sigmoidoscopy BPO:simultaneous BPO:sister BPO:skin BPO:slow_skin_healing BPO:small_intestine BPO:smeary_pattern A "smeary pattern" of oligomer triplets, in which there is no clear separation between oligomer triplets, is abnormal. BPO:son BPO:spontaneous BPO:spontaneous_delivery BPO:spontaneous_gum_bleeding BPO:spontaneous_or_traumatic Was the event spontaneous or did it occur after trauma? BPO:sports_injury BPO:stage_of_life BPO:stomach BPO:stone BPO:stone_removal BPO:stool_finding BPO:stroke BPO:study_subject BPO:subcutaneous_hematoma 0 BPO:subdural_hematoma BPO:subdural_space BPO:substitution 0 BPO:suction_bleeding Discuss with BSC - what do they mean here...? 0 BPO:surgery BPO:surgical_bleeding_treatment BPO:symptom-specific_treatment TODO: Is it necessary to enumerate all the different treatments? I.e., is it ok to just indicate epistaxis treatment, or is it necessary to specify nasal packing as a specific option? BPO:tampon BPO:telangiectasia BPO:thousand_cells_per_microliter BPO:time BPO:timing BPO:tissue_paper BPO:toddlerhood BPO:tongue BPO:tongue_bleeding BPO:tonsillectomy_adenoidectomy Synonym: Adenoids BPO:tooth_anatomic_classification BPO:tooth_eruption_bleeding 0 0 0 0 BPO:tooth_extraction 0 0 BPO:tooth_extraction_bleeding BPO:tooth_loss_bleeding BPO:tooth_subdivision BPO:tooth_temporal_classification BPO:topical_thrombin BPO:total_score BPO:tranexamic_acid BPO:transfusion 0 BPO:trauma 1 BPO:trauma_bleeding BPO:trauma_treatment BPO:traumatic BPO:traumatic_gum_bleeding BPO:treatment BPO:treatment_failure BPO:treatment_metadata BPO:trunk_subdivision BPO:tuberculosis BPO:type1 BPO:type2 BPO:type2a BPO:type2b BPO:type2m BPO:type2n BPO:type3 BPO:type_a BPO:type_ab BPO:type_b BPO:type_o BPO:ulcer BPO:ultrasound 0 BPO:umbilical_bleeding BPO:umbilical_cord BPO:umbilical_cord_separation BPO:uncle BPO:underlying_cause BPO:unfractionated_heparin 0 BPO:unique_identifier BPO:unique_personal_identification_number BPO:unit_of_measurement Specifies units of measurement for different laboratory evaluations. BPO:unspecified_answer Some questionnaire answers offer "don't remember" or "don't know" as choices. Additionally, respondents may on occasion skip certain questions. There is an "unspecified answer" in each of these scenarios. BPO:unusual_skin_texture BPO:upper BPO:upper_endoscopy BPO:ureter BPO:urethra BPO:urinary_tract_infection BPO:urine_finding BPO:urogenital_organ BPO:urologic_disorder BPO:urologic_malignancy BPO:uterine_artery_embolization BPO:uterine_bleeding_treatment BPO:uterine_brace_sutures BPO:uterine_fibroid BPO:uterine_polyp BPO:uterine_tamponade BPO:uterotonic_medication BPO:uterus BPO:venipuncture 0 BPO:venipuncture_bleeding BPO:vertical_location 0 30 BPO:vicenza_score BPO:viral_infection BPO:volume BPO:volume_fraction BPO:von_willebrand_disease BPO:von_willebrand_factor_antigen_level Reference url: http://en.wikipedia.org/wiki/Von_Willebrand_disease UMLS ID: 923 C2239219:von Willebrand's factor [Laboratory Procedure] BPO:von_willebrand_factor_assessment A von Willebrand factor (VWF) assessment is a hematologic evaluation pertaining to von Willebrand factor, a bloodborne clotting factor. BPO:von_willebrand_factor_botrocetin_cofactor von Willebrand factor botrocetin cofactor (VWF: BCo) is a measure of the activity of VWF in the presence of Botrocetin. BPO:von_willebrand_factor_collagen_binding Reference url: http://en.wikipedia.org/wiki/Von_Willebrand_disease BPO:von_willebrand_factor_multimers Reference url: http://www.ncbi.nlm.nih.gov/pubmed/18315556?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=5 VWF multimeric analysis is an assessment of the pattern and size of VWF multimers on gel electropheresis. Interpretation may be qualitative and/or quantitative via densimotry. BPO:von_willebrand_factor_multimers_qualitative This class represents VWF multimer results that have been interpreted qualitatively, i.e., "normal," "abnormal migration," "abnormal separation," etc. BPO:von_willebrand_factor_multimers_quantitative This class represents the results of VWF multimer that have been interpreted quantitatively, i.e., via densinometry. BPO:von_willebrand_factor_ristocetin_cofactor Reference url: http://en.wikipedia.org/wiki/Ristocetin von Willebrand factor ristocetin cofactor (VWF: RCo) is a measure of VWF-induced platelet aggregation in the presence of the antibiotic ristocetin. BPO:white_blood_cell_count The white blood cell count is the number of white blood cells present in a blood sample. UMLS ID: 1000 C0023508:Blood Cell Count, White (White Blood Cell Count procedure) [Laboratory Procedure] http://en.wikipedia.org/wiki/White_blood_cell_count#White_cells BPO:white_blood_cell_evaluation A white blood cell evaluation is a hematologic pertaining to white blood cells, i.e., leukocytes and lymphocytes. BPO:worsening_severity_with_age BPO:wrist owl:Thing - review event class - review event_property class - annotate classes - UMLS/OMIM/ICD-10 annotation - run classifier/reasoner - carefully review bleeding disorders and add "evaluated_by" conditions. For instance, VWD evaluated_by bleeding_score, evaluated_by VWF:Ag, etc. - re-review with all available questionnaires to ensure that 100% coverage is still present