Erick Antezana Frank Lin Richard Epstein Simon Kocbek Tudor Groza Creative Commons CC-BY 4.0 Creative Commons CC-BY 4.0 An ontology for cancer care (treatment outcome) in solid tumours 05:11:0018 00:00 cancer_care_treatment_outcome 1.4 Frank Po-Yen Lin definition database_cross_reference has_exact_synonym has_obo_format_version has_obo_namespace has_related_synonym cancer_care_treatment_outcome CCTO:000001 All CCTO:000001 UMLS:C1550401 cancer_care_treatment_outcome CCTO:000002 Value type CCTO:000002 UMLS:C0449238 cancer_care_treatment_outcome CCTO:000003 Duration CCTO:000003 UMLS:C0033204 cancer_care_treatment_outcome CCTO:000004 Probability CCTO:000004 cancer_care_treatment_outcome CCTO:000005 Timed probability CCTO:000005 cancer_care_treatment_outcome CCTO:000006 Event state CCTO:000006 cancer_care_treatment_outcome CCTO:000007 Relationship operator CCTO:000007 The concept has nominal value X cancer_care_treatment_outcome Has nominal value CCTO:000014 has_nominal_value CCTO:000014 The concept has canonical value X cancer_care_treatment_outcome Has canonical value CCTO:000015 has_canonical_value CCTO:000015 cancer_care_treatment_outcome CCTO:000016 Concept domain CCTO:000016 cancer_care_treatment_outcome CCTO:000017 Physical health-related concept CCTO:000017 event_t CCTO:000018(time_t t0) = EVENT_STATE(CCTO:000018, t0) cancer_care_treatment_outcome CCTO:000018 Neurocognitive function CCTO:000018 cancer_care_treatment_outcome CCTO:000019 Measure of concept CCTO:000019 cancer_care_treatment_outcome CCTO:000020 Measure of neurocognitive function CCTO:000020 mental health status. NCIT:C16839 UMLS:C0025353 Psychological health cancer_care_treatment_outcome CCTO:000021 Psychosocial health-related concept CCTO:000021 mental health status. NCIT:C16839 Psychological health NCIT:C16839 The subjective measurement of an individual's sense of well-being and ability to enjoy life. The concept holds varying meanings for different people and may evolve over time. For some individuals it implies autonomy, empowerment, capability, and choice; for others, security, social integration, or freedom from stress or illness. type_t CCTO:000022(time_t t0) = EVENT_STATE(CCTO:000022, t0) NCIT:C17047 UMLS:C0034380 UMLS:C0518214 QOL Quality-of-Life cancer_care_treatment_outcome Life quality Patient quality of life Quality of life measures CCTO:000022 QLQ C30; EORTC QLQ-C30 Quality of life CCTO:000022 The subjective measurement of an individual's sense of well-being and ability to enjoy life. The concept holds varying meanings for different people and may evolve over time. For some individuals it implies autonomy, empowerment, capability, and choice; for others, security, social integration, or freedom from stress or illness. NCIT:C17047 QOL NCIT:C17047 Quality-of-Life NCIT:C17047 cancer_care_treatment_outcome CCTO:000023 Measure of quality of life CCTO:000023 cancer_care_treatment_outcome Health service concepts CCTO:000024 Health service-related concept CCTO:000024 event_t CCTO:000025(time_t t0) = EVENT_STATE(CCTO:000025, t0) UMLS:C0030702 cancer_care_treatment_outcome CCTO:000025 Patient satisfaction CCTO:000025 cancer_care_treatment_outcome CCTO:000026 Measure of patient satisfaction CCTO:000026 event_t CCTO:000027(time_t t0) = EVENT_STATE(CCTO:000027, t0) UMLS:C0376409 cancer_care_treatment_outcome CCTO:000027 Patient preference CCTO:000027 cancer_care_treatment_outcome CCTO:000028 Measure of patient preference CCTO:000028 cancer_care_treatment_outcome CCTO:000029 Cancer treatment-related concept CCTO:000029 The probability of benefit to individuals in a defined population from a medical technology applied for a given medical problem under ideal conditions of use. Efficacy is a measure of effect of therapy among appropriate patients in whom treatment is tolerated and effectively administered, under the condition of sufficient patients' compliance, usually determined in randomized trials. type_t CCTO:000030(time_t t0) = EVENT_STATE(CCTO:000030, t0) NCIT:C39547 UMLS:C0087113 UMLS:C1280519 UMLS:C1707887 UMLS:C3850123 Treatment efficacy cancer_care_treatment_outcome Clinical efficacy Clinical outcomes CCTO:000030 Efficacy CCTO:000030 The probability of benefit to individuals in a defined population from a medical technology applied for a given medical problem under ideal conditions of use. Efficacy is a measure of effect of therapy among appropriate patients in whom treatment is tolerated and effectively administered, under the condition of sufficient patients' compliance, usually determined in randomized trials. NCIT:C39547 Treatment efficacy NCIT:C39547 cancer_care_treatment_outcome CCTO:000031 Measure of efficacy CCTO:000031 The state of the body as influenced by the diet and the ability of the diet to maintain an overall healthy condition. event_t CCTO:000032(time_t t0) = EVENT_STATE(CCTO:000032, t0) NCIT:C17993 UMLS:C0392209 cancer_care_treatment_outcome CCTO:000032 Nutritional status CCTO:000032 The state of the body as influenced by the diet and the ability of the diet to maintain an overall healthy condition. NCIT:C17993 cancer_care_treatment_outcome CCTO:000033 Measure of nutritional status CCTO:000033 A subject domain utilized for the submission of information encompassing and representing data, vocabulary or records related to healthcare resource utilization. unknown_t CCTO:000034(time_t t0) = EVENT_STATE(CCTO:000034, t0) NCIT:C49589 UMLS:C1704738 HU Healthcare resource utilization domain cancer_care_treatment_outcome Resource utilization CCTO:000034 Healthcare resource utilization CCTO:000034 A subject domain utilized for the submission of information encompassing and representing data, vocabulary or records related to healthcare resource utilization. NCIT:C49589 HU NCIT:C49589 Healthcare resource utilization domain NCIT:C49589 cancer_care_treatment_outcome CCTO:000035 Measure of healthcare resource utilization CCTO:000035 A measure of how well a patient is able to perform ordinary tasks and carry out daily activities. type_t CCTO:000036(time_t t0) = EVENT_STATE(CCTO:000036, t0) NCIT:C20641 UMLS:C1518965 cancer_care_treatment_outcome CCTO:000036 Performance status CCTO:000036 A measure of how well a patient is able to perform ordinary tasks and carry out daily activities. NCIT:C20641 cancer_care_treatment_outcome CCTO:000037 Measure of performance status CCTO:000037 The bodily processes that include arousal, erection, orgasm, and ejaculation. event_t CCTO:000038(time_t t0) = EVENT_STATE(CCTO:000038, t0) NCIT:C118256 UMLS:C0278092 cancer_care_treatment_outcome CCTO:000038 Sexual function CCTO:000038 The bodily processes that include arousal, erection, orgasm, and ejaculation. NCIT:C118256 cancer_care_treatment_outcome CCTO:000039 Measure of sexual function CCTO:000039 The amount of money needed to buy, do or make something OR The amount paid, charged, or engaged to be paid, for purchasing goods, services and financial instruments. event_t CCTO:000040(time_t t0) = EVENT_STATE(CCTO:000040, t0) NCIT:C16471 NCIT:C69088 UMLS:C0010186 UMLS:C0085552 UMLS:C0087112 Cost cancer_care_treatment_outcome Health care costs Treatment costs CCTO:000040 Costs CCTO:000040 The amount of money needed to buy, do or make something OR The amount paid, charged, or engaged to be paid, for purchasing goods, services and financial instruments. NCIT:C16471 NCIT:C69088 Cost NCIT:C16471 Cost NCIT:C69088 cancer_care_treatment_outcome CCTO:000041 Measure of costs CCTO:000041 The state of being certain that adverse effects will not be caused by some agent under defined conditions. type_t CCTO:000042(time_t t0) = EVENT_STATE(CCTO:000042, t0) NCIT:C60828 UMLS:C0036043 UMLS:C1705187 cancer_care_treatment_outcome Overall safety Safety endpoints Safety measures Safety parameters CCTO:000042 adverse events Safety CCTO:000042 The state of being certain that adverse effects will not be caused by some agent under defined conditions. NCIT:C60828 cancer_care_treatment_outcome CCTO:000043 Measure of safety CCTO:000043 The act of abiding by a stated treatment plan or protocol OR The extent to which a patient conforms to medical advice regarding prescribed regimen, lifestyle, dietary changes, follow-up schedule and other recommendations. event_t CCTO:000044(time_t t0) = EVENT_STATE(CCTO:000044, t0) NCIT:C25729 NCIT:C39490 UMLS:C0009563 UMLS:C0566588 UMLS:C1321605 UMLS:C1510802 UMLS:C3244300 Compliance Compliant Patient compliance cancer_care_treatment_outcome Treatment compliance CCTO:000044 Adherence CCTO:000044 The act of abiding by a stated treatment plan or protocol OR The extent to which a patient conforms to medical advice regarding prescribed regimen, lifestyle, dietary changes, follow-up schedule and other recommendations. NCIT:C25729 NCIT:C39490 Compliance NCIT:C39490 Compliant NCIT:C39490 Patient compliance NCIT:C39490 cancer_care_treatment_outcome CCTO:000045 Measure of adherence CCTO:000045 A type of safety study that assesses the degree to which overt adverse effects can be tolerated by the subject. type_t CCTO:000046(time_t t0) = EVENT_STATE(CCTO:000046, t0) NCIT:C98791 UMLS:C0220929 UMLS:C0231197 UMLS:C1704410 UMLS:C3274448 Tolerability study cancer_care_treatment_outcome Tolerance Treatment tolerance CCTO:000046 Tolerability CCTO:000046 A type of safety study that assesses the degree to which overt adverse effects can be tolerated by the subject. NCIT:C98791 Tolerability study NCIT:C98791 cancer_care_treatment_outcome CCTO:000047 Measure of tolerability CCTO:000047 The finding of bodily harm due to the poisonous effects of something. type_t CCTO:000048(time_t t0) = EVENT_STATE(CCTO:000048, t0) NCIT:C27990 UMLS:C0040539 UMLS:C0600688 TOX cancer_care_treatment_outcome Overall toxicity Qualitative and quantitative toxicities Toxic effects Toxicities Treatment toxicity CCTO:000048 Toxicity CCTO:000048 The finding of bodily harm due to the poisonous effects of something. NCIT:C27990 TOX NCIT:C27990 Any unfavorable or unintended disease, sign, or symptom (including an abnormal laboratory finding) that is temporally associated with the use of a medical treatment or procedure, and that may or may not be considered related to the medical treatment or procedure. Such events can be related to the intervention, dose, route of administration, patient, or caused by an interaction with another drug(s) or procedure(s). CCTO:000049 implies CCTO:000043 event_t CCTO:000049(time_t t0) = EVENT_STATE(CCTO:000049, t0) NCIT:C41331 UMLS:C0001688 UMLS:C0877248 UMLS:C0879626 UMLS:C1705413 AE Adverse event Adverse experience AdverseEvent cancer_care_treatment_outcome Adverse effects Other adverse events CCTO:000049 Adverse events CCTO:000049 Any unfavorable or unintended disease, sign, or symptom (including an abnormal laboratory finding) that is temporally associated with the use of a medical treatment or procedure, and that may or may not be considered related to the medical treatment or procedure. Such events can be related to the intervention, dose, route of administration, patient, or caused by an interaction with another drug(s) or procedure(s). NCIT:C41331 AE NCIT:C41331 Adverse event NCIT:C41331 Adverse experience NCIT:C41331 AdverseEvent NCIT:C41331 cancer_care_treatment_outcome CCTO:000050 Assessment tool CCTO:000050 UMLS:C1261322 UMLS:C1552578 cancer_care_treatment_outcome Investigations CCTO:000051 Investigation CCTO:000051 UMLS:C0034394 UMLS:C1706422 cancer_care_treatment_outcome Patient questionnaires Questionnaire Questionnaires CCTO:000052 Patient questionnaire CCTO:000052 cancer_care_treatment_outcome CCTO:000053 Clinical criteria CCTO:000053 cancer_care_treatment_outcome treatment-start CCTO:000054 Treatment start CCTO:000054 cancer_care_treatment_outcome treatment-end CCTO:000055 Treatment end CCTO:000055 CCTO:000056 implies CCTO:000070 CCTO:000056 implies NOT CCTO:000059 CCTO:000056 implies NOT CCTO:000218 NOT CCTO:000056 implies CCTO:000059 UMLS:C0277565 cancer_care_treatment_outcome local disease CCTO:000056 Has local disease CCTO:000056 A disease or condition that extends beyond the site and spreads into adjacent tissues and regional lymph nodes. CCTO:000057 implies CCTO:000070 CCTO:000057 implies NOT CCTO:000060 CCTO:000057 implies NOT CCTO:000218 NOT CCTO:000057 implies CCTO:000060 NCIT:C41844 UMLS:C1514819 Regional disease cancer_care_treatment_outcome CCTO:000057 Has regional disease CCTO:000057 A disease or condition that extends beyond the site and spreads into adjacent tissues and regional lymph nodes. NCIT:C41844 Regional disease NCIT:C41844 A biological process that involves the transfer and growth of cancer cells from the site of the primary tumor. Relocation of malignant cells during metastasis can be restricted to movement within a specific tissue/organ or may entail migration to a distal locus within the body. This phenotype is a characteristic of all malignant tumors. CCTO:000058 implies CCTO:000058 CCTO:000058 implies CCTO:000070 CCTO:000058 implies CCTO:000139 CCTO:000058 implies NOT CCTO:000061 CCTO:000058 implies NOT CCTO:000218 NOT CCTO:000058 implies CCTO:000061 event_t CCTO:000058(time_t t0) = EVENT_STATE(CCTO:000058, t0) event_t NULL NCIT:C18206 NCIT:C19151 UMLS:C0027627 UMLS:C1269798 Distant cancer Distant metastasis Metastasis Metastasize Tumor cell migration cancer_care_treatment_outcome Distant disease Distant metastases Metastases CCTO:000058 Has metastasis CCTO:000058 A biological process that involves the transfer and growth of cancer cells from the site of the primary tumor. Relocation of malignant cells during metastasis can be restricted to movement within a specific tissue/organ or may entail migration to a distal locus within the body. This phenotype is a characteristic of all malignant tumors. NCIT:C18206 Distant cancer NCIT:C18206 Distant metastasis NCIT:C18206 Metastasis NCIT:C19151 Metastasize NCIT:C19151 Tumor cell migration NCIT:C19151 CCTO:000059 implies CCTO:000106 CCTO:000059 implies NOT CCTO:000056 NOT CCTO:000059 implies CCTO:000056 cancer_care_treatment_outcome CCTO:000059 Local disease-free CCTO:000059 CCTO:000060 implies CCTO:001133 CCTO:000060 implies NOT CCTO:000057 NOT CCTO:000060 implies CCTO:000057 cancer_care_treatment_outcome CCTO:000060 Regional disease-free CCTO:000060 CCTO:000061 implies NOT CCTO:000058 NOT CCTO:000061 implies CCTO:000058 cancer_care_treatment_outcome CCTO:000061 Metastasis-free CCTO:000061 A measure of the time until death from any cause. CCTO:000062 = time-to-first CCTO:000114 duration_t CCTO:000062(time_t t0) = time_to_first_event(time_t t0, CCTO:000114) NCIT:C125201 UMLS:C0038952 UMLS:C0220921 cancer_care_treatment_outcome Duration of overall survival Duration of survival Global survival Kaplan-Meier Estimate for Overall Survival OS Over all survival Overall patient survival Overall survivals Patient survival Survival Time to death CCTO:000062 OS Overall survival CCTO:000062 A measure of the time until death from any cause. NCIT:C125201 CCTO:000063 = time-to-first CCTO:000114 CCTO:000064 duration_t CCTO:000063(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000064) ) NCIT:C28234 UMLS:C0242792 PFS cancer_care_treatment_outcome Composite Progression-free Survival Disease progression-free survival Duration of PFS Duration of progression-free survival Overall progression-free survival Progression free survival CCTO:000063 PFS Progression-free survival CCTO:000063 PFS NCIT:C28234 A pathologic process in which alterations at the molecular level result in a more aggressive cytologic and phenotypic profile and clinical course of a neoplasm OR A disease process that is increasing in scope or severity OR A pathologic process in which alterations at the molecular level result in a more aggressive cytologic and phenotypic profile and clinical course of a malignant neoplasm OR Process of disease spreading and/or increase of its severity OR The worsening of a disease over time. CCTO:000064 globally-implies CCTO:000064 CCTO:000064 implies CCTO:000070 CCTO:000064 implies NOT CCTO:000065 CCTO:000064 implies NOT CCTO:000073 CCTO:000064 implies NOT CCTO:000078 CCTO:000064 implies NOT CCTO:000082 CCTO:000064 implies NOT CCTO:000099 CCTO:000064 implies NOT CCTO:000144 CCTO:000064 implies NOT CCTO:000201 NOT CCTO:000064 implies CCTO:000073 NOT CCTO:000064 implies CCTO:000144 event_t CCTO:000064(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000064, t0, assessed_at) NCIT:C17609 NCIT:C17747 NCIT:C19987 NCIT:C25331 NCIT:C35571 NCIT:C8510 UMLS:C0178874 UMLS:C0242656 UMLS:C0677932 UMLS:C1335499 UMLS:C1947901 UMLS:C3539781 Cancer disease progression Cancer progression Progression Progressive disease Progressive neoplastic disease Tumor progression cancer_care_treatment_outcome Overall progression progression of disease tumour progression CCTO:000064 Disease progression CCTO:000064 A pathologic process in which alterations at the molecular level result in a more aggressive cytologic and phenotypic profile and clinical course of a neoplasm OR A disease process that is increasing in scope or severity OR A pathologic process in which alterations at the molecular level result in a more aggressive cytologic and phenotypic profile and clinical course of a malignant neoplasm OR Process of disease spreading and/or increase of its severity OR The worsening of a disease over time. NCIT:C17609 NCIT:C17747 NCIT:C19987 NCIT:C25331 NCIT:C35571 Cancer disease progression NCIT:C19987 Cancer progression NCIT:C19987 Progression NCIT:C17747 Progression NCIT:C25331 Progressive disease NCIT:C35571 Progressive neoplastic disease NCIT:C8510 Tumor progression NCIT:C17609 An assessment of the overall response of the disease to the therapy. CCTO:000065 implies NOT CCTO:000064 CCTO:000065 implies NOT CCTO:000099 CCTO:000065 is-union-of CCTO:000082 CCTO:000201 CCTO:000082 implies CCTO:000065 CCTO:000201 implies CCTO:000065 event_t CCTO:000065(time_t t0, time_t assessed_at) = CCTO:000082(t0, assessed_at) OR CCTO:000201(t0, assessed_at) NCIT:C96613 UMLS:C0521982 UMLS:C1704632 UMLS:C1706817 UMLS:C3272903 OVRLRESP Overall response cancer_care_treatment_outcome Anti-tumor response Confirmed response Disease response Objective overall response Objective response Objective tumor response Overall objective response Overall tumor response Patient response Response Response to chemotherapy Response to therapy Response to treatment Tumor response Tumor shrinkage Tumoral response Tumour response Tumour shrinkage CCTO:000065 Treatment response CCTO:000065 An assessment of the overall response of the disease to the therapy. NCIT:C96613 OVRLRESP NCIT:C96613 Overall response NCIT:C96613 duration_t CCTO:000066(time_t t0) = duration_of_event(CCTO:000065, t0) UMLS:C0237585 cancer_care_treatment_outcome Duration of objective response Duration of overall response Duration of tumor response Overall response duration Response duration CCTO:000066 Duration of response CCTO:000066 CCTO:000067 = time-to-first CCTO:000064 duration_t CCTO:000067(time_t t0) = time_to_first_event(CCTO:000064, t0) NCIT:C93153 UMLS:C0034155 UMLS:C2985467 UMLS:C3539814 TTP cancer_care_treatment_outcome Progression-free interval Time to Progressive Disease Time to Tumor Progression Time to disease progression Time to progression of disease Time to tumour progression CCTO:000067 TTP Time to progression CCTO:000067 TTP NCIT:C93153 probability_t CCTO:000068(time_t t0, time_t assessed_at) = probability(CCTO:000065(t0, assessed_at) == TRUE, assessed_at) NCIT:C94502 UMLS:C0237629 Response rate cancer_care_treatment_outcome Confirmed response rate Disease response rate ORR Objective Rate of Response Objective overall response rate Objective response rate Objective response rates Objective tumor response rate Overall objective response rate Overall response rates Response rates Tumor response rate Tumour response rate CCTO:000068 ORR; CR + PR; complete and partial response; Complete and Partial Response; CR+PR; complete and partial; OR; ORR = CR + PR; complete response and partial response Overall response rate CCTO:000068 Response rate NCIT:C94502 The length of time after treatment for a specific disease during which a patient survives with no sign of recurrence of the disease. CCTO:000069 = time-to-first CCTO:000114 CCTO:000070 duration_t CCTO:000069(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000070) ) NCIT:C17751 UMLS:C0242793 cancer_care_treatment_outcome DFS Disease free survival CCTO:000069 Disease-free survival CCTO:000069 The length of time after treatment for a specific disease during which a patient survives with no sign of recurrence of the disease. NCIT:C17751 A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. CCTO:000070 globally-implies CCTO:000070 CCTO:000070 implies CCTO:000139 CCTO:000070 implies NOT CCTO:000082 CCTO:000070 implies NOT CCTO:000218 NOT CCTO:000070 implies CCTO:000218 event_t CCTO:000070(time_t t0) = EVENT_STATE(CCTO:000070, t0) NCIT:C9305 UMLS:C0006826 UMLS:C0012634 UMLS:C0497565 UMLS:C1306459 CA Cancer Malignancy Malignant growth Malignant neoplasm Malignant neoplastic disease Malignant tumor NEOPLASM, MALIGNANT cancer_care_treatment_outcome Disease CCTO:000070 Has disease CCTO:000070 A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. NCIT:C9305 CA NCIT:C9305 Cancer NCIT:C9305 Malignancy NCIT:C9305 Malignant growth NCIT:C9305 Malignant neoplasm NCIT:C9305 Malignant neoplastic disease NCIT:C9305 Malignant tumor NCIT:C9305 NEOPLASM, MALIGNANT NCIT:C9305 The length of time after treatment during which a patient survives with no sign of a particular complication of disease. CCTO:000071 = time-to-first CCTO:000114 CCTO:000137 duration_t CCTO:000071(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000072) ) NCIT:C96340 UMLS:C0242793 UMLS:C1424622 EFS cancer_care_treatment_outcome Event free survival CCTO:000071 Event-free survival CCTO:000071 The length of time after treatment during which a patient survives with no sign of a particular complication of disease. NCIT:C96340 EFS NCIT:C96340 Something that happens at a given place and time. CCTO:000072 implies CCTO:000043 event_t CCTO:000072(time_t t0) = EVENT_STATE(CCTO:000072, t0) NCIT:C25499 UMLS:C0441471 cancer_care_treatment_outcome CCTO:000072 Event CCTO:000072 Something that happens at a given place and time. NCIT:C25499 CCTO:000073 globally-implies CCTO:000073 CCTO:000073 implies CCTO:000078 CCTO:000073 implies NOT CCTO:000064 CCTO:000073 is-union-of CCTO:000082 CCTO:000201 CCTO:000099 CCTO:000082 implies CCTO:000073 CCTO:000099 implies CCTO:000073 CCTO:000201 implies CCTO:000073 NOT CCTO:000073 implies CCTO:000064 event_t CCTO:000073(time_t t0, time_t assessed_at) = CCTO:000082(t0, assessed_at) OR CCTO:000201(t0, assessed_at) OR CCTO:000099(t0, assessed_at) UMLS:C0920467 cancer_care_treatment_outcome Disease stabilization Tumor control CCTO:000073 Disease control CCTO:000073 probability_t CCTO:000074(time_t t0) = probability(CCTO:000073, t0) cancer_care_treatment_outcome Tumor control rate CCTO:000074 CR+PR+SD Disease control rate CCTO:000074 The lack of expected or desired effect related to a therapy. CCTO:000075 implies CCTO:000043 CCTO:000075 implies NOT CCTO:000223 event_t CCTO:000075(time_t t0) = NOT CCTO:000223(t0) NCIT:C48226 UMLS:C0162643 UMLS:C0231174 UMLS:C0235828 UMLS:C0680095 UMLS:C1547544 Efficacy lack Lack of Efficacy cancer_care_treatment_outcome Failure failure of strategy CCTO:000075 Treatment failure CCTO:000075 The lack of expected or desired effect related to a therapy. NCIT:C48226 Efficacy lack NCIT:C48226 Lack of Efficacy NCIT:C48226 CCTO:000076 = time-to-first CCTO:000075 duration_t CCTO:000076(time_t t0) = time_to_first_event(CCTO:000075, t0) cancer_care_treatment_outcome Time to failure of strategy CCTO:000076 Time to treatment failure CCTO:000076 CCTO:000077 = time-to-first CCTO:000065 duration_t CCTO:000077(time_t t0) = time_to_first_event(CCTO:000065, t0) cancer_care_treatment_outcome Time to First Response Time to Objective Response Time to Tumor Response Time to onset of response CCTO:000077 Time to response CCTO:000077 CCTO:000078 globally-implies CCTO:000078 CCTO:000078 implies CCTO:000073 CCTO:000078 implies NOT CCTO:000064 CCTO:000078 is-union-of CCTO:000082 CCTO:000201 CCTO:000099 CCTO:000082 implies CCTO:000078 CCTO:000099 implies CCTO:000078 CCTO:000201 implies CCTO:000078 event_t CCTO:000078(time_t t0, time_t assessed_at) = CCTO:000082(t0, assessed_at) OR CCTO:000201(t0, assessed_at) OR CCTO:000099(t0, assessed_at) cancer_care_treatment_outcome CCTO:000078 Clinical benefit CCTO:000078 probability_t CCTO:000079(time_t t0) = probability(CCTO:000078, t0) cancer_care_treatment_outcome CCTO:000079 Clinical benefit rate CCTO:000079 CCTO:000080 = time-to-first CCTO:000114 CCTO:000081 duration_t CCTO:000080(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000081) ) UMLS:C0341703 cancer_care_treatment_outcome RFS CCTO:000080 Relapse-free survival CCTO:000080 The return of a disease after a period of remission. CCTO:000081 implies CCTO:000064 CCTO:000081 implies CCTO:000070 event_t CCTO:000081(time_t t0, time_t assessed_at) = ( CCTO:000070(t0) AND CCTO:000064(t0, assessed_at) ) NCIT:C18265 NCIT:C38155 UMLS:C0035020 UMLS:C0277556 DISEASE RELAPSE Recurrent disease Relapse, site not specified Relapsed disease cancer_care_treatment_outcome CCTO:000081 Relapse CCTO:000081 The return of a disease after a period of remission. NCIT:C38155 DISEASE RELAPSE NCIT:C38155 Recurrent disease NCIT:C38155 Relapse, site not specified NCIT:C38155 Relapsed disease NCIT:C38155 The disappearance of all signs of cancer in response to treatment. CCTO:000082 implies CCTO:000065 CCTO:000082 implies NOT CCTO:000064 CCTO:000082 implies NOT CCTO:000070 CCTO:000082 implies NOT CCTO:000099 CCTO:000082 implies NOT CCTO:000201 event_t CCTO:000082(time_t t0) = EVENT_STATE(CCTO:000082, t0) event_t CCTO:000082(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000082, t0, assessed_at) NCIT:C4870 UMLS:C0677874 Cancer-free Complete remission cancer_care_treatment_outcome Confirmed complete response CCTO:000082 Complete response CCTO:000082 The disappearance of all signs of cancer in response to treatment. NCIT:C4870 Cancer-free NCIT:C4870 Complete remission NCIT:C4870 probability_t CCTO:000083(time_t t0, time_t assessed_at) = probability(CCTO:000082(t0, assessed_at) == TRUE, assessed_at) cancer_care_treatment_outcome CR rate Complete remission rate CCTO:000083 CR Complete response rate CCTO:000083 CCTO:000084 implies CCTO:000118 event_t CCTO:000084(time_t t0) = EVENT_STATE(CCTO:000084, t0) cancer_care_treatment_outcome Health Related Quality of Life CCTO:000084 Health-related quality of life CCTO:000084 probability_t CCTO:000085(time_t t0, time_t assessed_at) = probability(CCTO:000062(t0), assessed_at) NCIT:C28192 UMLS:C0038954 Survival rate cancer_care_treatment_outcome OS rate Overall survival rates Survival probability Survival rates CCTO:000085 OS Overall survival rate CCTO:000085 Survival rate NCIT:C28192 CCTO:000086 = time-to-first CCTO:000114 CCTO:000087 duration_t CCTO:000086(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000087) ) cancer_care_treatment_outcome CCTO:000086 Recurrence-free survival CCTO:000086 The reemergence of a malignant neoplasm after a period of remission. CCTO:000087 implies CCTO:000064 CCTO:000087 implies CCTO:000070 CCTO:000087 implies NOT CCTO:000168 NOT CCTO:000087 implies CCTO:000168 event_t CCTO:000087(time_t t0, time_t assessed_at) = ( NOT CCTO:000070(t0) AND CCTO:000070(assessed_at) ) NCIT:C4813 UMLS:C0521158 UMLS:C0549379 UMLS:C0679254 UMLS:C1458156 UMLS:C2825055 Recurrent cancer Recurrent malignant neoplasm Recurrent malignant tumor cancer_care_treatment_outcome Disease recurrence tumor recurrence CCTO:000087 Recurrence CCTO:000087 The reemergence of a malignant neoplasm after a period of remission. NCIT:C4813 Recurrent cancer NCIT:C4813 Recurrent malignant neoplasm NCIT:C4813 Recurrent malignant tumor NCIT:C4813 The disappearance of all signs of cancer, supported by pathological examination. event_t CCTO:000088(time_t t0) = EVENT_STATE(CCTO:000088, t0) event_t CCTO:000088(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000088, t0, assessed_at) NCIT:C123603 UMLS:C0032520 UMLS:C0677874 Complete pathological response Pathologic complete remission Pathological complete remission pCR cancer_care_treatment_outcome Pathological complete response CCTO:000088 Pathologic complete response CCTO:000088 The disappearance of all signs of cancer, supported by pathological examination. NCIT:C123603 Complete pathological response NCIT:C123603 Pathologic complete remission NCIT:C123603 Pathological complete remission NCIT:C123603 pCR NCIT:C123603 The most clinically favorable response recorded from the start of the study treatment until the end of treatment. event_t CCTO:000089(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000089, t0, assessed_at) NCIT:C94536 UMLS:C2986560 BESTRESP Best response cancer_care_treatment_outcome Best objective response Best overall tumor response Best tumor response Overall best response CCTO:000089 Best overall response CCTO:000089 The most clinically favorable response recorded from the start of the study treatment until the end of treatment. NCIT:C94536 BESTRESP NCIT:C94536 Best response NCIT:C94536 CCTO:000090 implies CCTO:000098 CCTO:000090 implies CCTO:000114 event_t CCTO:000090(time_t t0) = CCTO:000114(t0) AND ASSOCIATED(CCTO:000114, CCTO:000223) cancer_care_treatment_outcome CCTO:000090 Treatment-related mortality CCTO:000090 probability_t CCTO:000091(time_t t0, time_t assessed_at) = probability(CCTO:000063(t0), assessed_at) cancer_care_treatment_outcome PFS rate Progression free survival rate Progression free survival rates CCTO:000091 Progression-free survival rate CCTO:000091 An evaluation of the clinical response of the disease to the therapy. CCTO:000092 implies NOT CCTO:000175 event_t CCTO:000092(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000092, t0, assessed_at) NCIT:C123619 CLINRESP cancer_care_treatment_outcome CCTO:000092 Clinical response CCTO:000092 An evaluation of the clinical response of the disease to the therapy. NCIT:C123619 CLINRESP NCIT:C123619 probability_t CCTO:000093(time_t t0, time_t assessed_at) = probability(CCTO:000092(t0, assessed_at) == TRUE, assessed_at) cancer_care_treatment_outcome Clinical response rates CCTO:000093 Clinical response rate CCTO:000093 CCTO:000094 = time-to-first CCTO:000114 CCTO:000075 duration_t CCTO:000094(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000075) ) cancer_care_treatment_outcome CCTO:000094 Failure-free survival CCTO:000094 probability_t CCTO:000095(time_t t0, time_t assessed_at) = probability(CCTO:000089(t0, assessed_at) == TRUE, assessed_at) cancer_care_treatment_outcome Best response rate best objective response rate CCTO:000095 Best overall response rate CCTO:000095 The ratio of deaths in an area to the population of that area, expressed as deaths per 1000 per year. CCTO:000096 implies CCTO:000043 CCTO:000096 implies CCTO:000114 event_t CCTO:000096(time_t t0) = CCTO:000114(t0) NCIT:C16880 UMLS:C0026565 cancer_care_treatment_outcome All-cause mortality Overall mortality CCTO:000096 Mortality CCTO:000096 The ratio of deaths in an area to the population of that area, expressed as deaths per 1000 per year. NCIT:C16880 CCTO:000097 = time-to-first CCTO:000114 CCTO:000087 duration_t CCTO:000097(time_t t0) = time_to_first_event(CCTO:000087, t0) cancer_care_treatment_outcome Recurrence-free interval CCTO:000097 Time to recurrence CCTO:000097 CCTO:000098 implies CCTO:000049 CCTO:000098 implies CCTO:000137 unknown_t CCTO:000098(time_t t0) = EVENT_STATE(CCTO:000098, t0) cancer_care_treatment_outcome Treatment emergent adverse events Treatment related adverse events Treatment related morbidity Treatment-emergent adverse events Treatment-related adverse events CCTO:000098 Safety and Tolerability Treatment-related adverse events CCTO:000098 Cancer that is neither decreasing nor increasing in extent or severity. CCTO:000099 implies NOT CCTO:000064 CCTO:000099 implies NOT CCTO:000065 CCTO:000099 implies NOT CCTO:000082 CCTO:000099 implies NOT CCTO:000201 event_t CCTO:000099(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000099, t0, assessed_at) NCIT:C18213 UMLS:C0677946 UMLS:C3538874 cancer_care_treatment_outcome CCTO:000099 Stable disease CCTO:000099 Cancer that is neither decreasing nor increasing in extent or severity. NCIT:C18213 duration_t CCTO:000100(time_t t0) = duration_of_event(CCTO:000099, t0) cancer_care_treatment_outcome CCTO:000100 Duration of stable disease CCTO:000100 CCTO:000101 implies CCTO:000163 event_t CCTO:000101(time_t t0) = EVENT_STATE(CCTO:000101, t0) cancer_care_treatment_outcome curative resection CCTO:000101 R0 resection CCTO:000101 probability_t CCTO:000102(time_t t0) = probability(CCTO:000101, t0) cancer_care_treatment_outcome curative resection rate CCTO:000102 R0 resection rate CCTO:000102 The amount of prostate specific antigen is increased, based on pre-defined thresholds. CCTO:000103 implies CCTO:001107 CCTO:000103 implies NOT CCTO:000120 CCTO:000103 implies NOT CCTO:000295 event_t CCTO:000103(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000103, t0, assessed_at) NCIT:C123611 cancer_care_treatment_outcome CCTO:000103 PSA progression CCTO:000103 The amount of prostate specific antigen is increased, based on pre-defined thresholds. NCIT:C123611 CCTO:000104 = time-to-first CCTO:000103 duration_t CCTO:000104(time_t t0) = time_to_first_event(CCTO:000103, t0) cancer_care_treatment_outcome CCTO:000104 Time to PSA progression CCTO:000104 CCTO:000105 = time-to-first CCTO:001102 duration_t CCTO:000105(time_t t0) = EVENT_STATE(CCTO:001102, t0) ? CCTO:000062(t0) : NULL NCIT:C53371 UMLS:C1707318 Cause specific survival cancer_care_treatment_outcome Cancer-specific survival Specific survival CCTO:000105 Disease-specific survival CCTO:000105 Cause specific survival NCIT:C53371 CCTO:000106 implies NOT CCTO:000147 CCTO:000106 implies NOT CCTO:000153 CCTO:000106 implies NOT CCTO:000244 event_t CCTO:000106(time_t t0) = EVENT_STATE(CCTO:000106, t0) cancer_care_treatment_outcome Local tumor control CCTO:000106 Local control CCTO:000106 The sensation of discomfort, distress, or agony, resulting from the stimulation of specialized nerve endings OR A disorder characterized by the sensation of marked discomfort, distress or agony. CCTO:000107 implies CCTO:000049 CCTO:000107 implies CCTO:001103 NCI:CTCAE:10033371 NCIT:C3303 UMLS:C0030193 UMLS:C2598155 cancer_care_treatment_outcome CCTO:000107 Pain CCTO:000107 The sensation of discomfort, distress, or agony, resulting from the stimulation of specialized nerve endings OR A disorder characterized by the sensation of marked discomfort, distress or agony. NCI:CTCAE NCIT:C3303 Any immune system response of an organisms to an internal or invasive threat. event_t CCTO:000108(time_t t0) = EVENT_STATE(CCTO:000108, t0) NCIT:C17930 UMLS:C0301872 Immune response process cancer_care_treatment_outcome Immunological response CCTO:000108 Immune response CCTO:000108 Any immune system response of an organisms to an internal or invasive threat. NCIT:C17930 Immune response process NCIT:C17930 probability_t CCTO:000109(time_t t0, time_t assessed_at) = probability(CCTO:000087(t0, assessed_at) == TRUE, assessed_at) cancer_care_treatment_outcome Recurrence rates CCTO:000109 Recurrence rate CCTO:000109 The term was used in various ways in the past, to describe unintended effects of medical intervention, usually negative (unfavourable), but also positive (favourable) ones. It is recommended that this term no longer be used and particularly should not be regarded as synonymous with adverse event or adverse reaction. CCTO:000110 implies CCTO:000049 event_t CCTO:000110(time_t t0) = EVENT_STATE(CCTO:000110, t0) NCIT:C2861 UMLS:C0001688 UMLS:C0879626 Side effect cancer_care_treatment_outcome CCTO:000110 Side effects CCTO:000110 The term was used in various ways in the past, to describe unintended effects of medical intervention, usually negative (unfavourable), but also positive (favourable) ones. It is recommended that this term no longer be used and particularly should not be regarded as synonymous with adverse event or adverse reaction. NCIT:C2861 Side effect NCIT:C2861 CCTO:000111 = time-to-first CCTO:000114 CCTO:000112 duration_t CCTO:000111(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000112) ) cancer_care_treatment_outcome Radiologic progression free survival Radiological progression free survival CCTO:000111 Radiographic progression-free survival CCTO:000111 CCTO:000112 implies NOT CCTO:000159 event_t CCTO:000112(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000112, t0, assessed_at) cancer_care_treatment_outcome CCTO:000112 Radiographic progression CCTO:000112 CCTO:000113 = measured-from-first CCTO:000150 time-to-last CCTO:000150 duration_t CCTO:000113(time_t t0) = duration_of_event(CCTO:000150, t0) UMLS:C0023303 cancer_care_treatment_outcome Duration of hospital stay Duration of hospitalization Hospital length of stay Hospitalization time Length of stay CCTO:000113 Length of hospital stay CCTO:000113 The cessation of life OR A cessation of life that cannot be attributed to a CTCAE term associated with Grade 5. CCTO:000114 globally-implies CCTO:000114 CCTO:000114 implies CCTO:000049 CCTO:000114 implies CCTO:001103 true CCTO:000114(time_t t0) = EVENT_STATE(CCTO:000114, t0) event_t CCTO:000114(time_t t0) = EVENT_STATE(CCTO:000114, t0) NCI:CTCAE:10011914 NCIT:C28554 NCIT:C55284 UMLS:C0011065 UMLS:C1306577 UMLS:C1546949 UMLS:C1549070 UMLS:C1549464 Dead Death Adverse Event Not Associated with More Specific CTCAE Term NOS Death NOS Deceased Died EXPIRED Expired/death cancer_care_treatment_outcome CCTO:000114 Death CCTO:000114 The cessation of life OR A cessation of life that cannot be attributed to a CTCAE term associated with Grade 5. NCI:CTCAE NCIT:C28554 Dead NCIT:C28554 Death Adverse Event Not Associated with More Specific CTCAE Term NOS NCIT:C55284 Death NOS NCIT:C28554 Death NOS NCIT:C55284 Deceased NCIT:C28554 Died NCIT:C28554 EXPIRED NCIT:C28554 Expired/death NCIT:C28554 CCTO:000115 = time-to-first CCTO:000114 CCTO:000058 duration_t CCTO:000115(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000058) ) cancer_care_treatment_outcome Metastases-free survival CCTO:000115 Metastasis-free survival CCTO:000115 CCTO:000116 implies CCTO:000043 event_t CCTO:000116(time_t t0) = EVENT_STATE(CCTO:000116, t0) cancer_care_treatment_outcome Next therapy CCTO:000116 Next treatment CCTO:000116 CCTO:000117 = time-to-first CCTO:000116 duration_t CCTO:000117(time_t t0) = time_to_first_event(CCTO:000116, t0) cancer_care_treatment_outcome Time to Next Therapy CCTO:000117 Time to next treatment CCTO:000117 Information collected directly from a patient that typically includes subjective feelings regarding symptoms, functions in daily life, physical, mental, emotional, spiritual, and social well being, and satisfaction with his/her health care. event_t CCTO:000118(time_t t0) = EVENT_STATE(CCTO:000118, t0) NCIT:C95401 UMLS:C0033382 UMLS:C2987124 PRO Patient reported outcome cancer_care_treatment_outcome CCTO:000118 Patient reported outcomes CCTO:000118 Information collected directly from a patient that typically includes subjective feelings regarding symptoms, functions in daily life, physical, mental, emotional, spiritual, and social well being, and satisfaction with his/her health care. NCIT:C95401 PRO NCIT:C95401 Patient reported outcome NCIT:C95401 probability_t CCTO:000119(time_t t0) = probability(CCTO:000106, t0) cancer_care_treatment_outcome CCTO:000119 Local control rate CCTO:000119 CCTO:000120 implies CCTO:000295 CCTO:000120 implies NOT CCTO:000103 event_t CCTO:000120(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000120, t0, assessed_at) cancer_care_treatment_outcome CCTO:000120 PSA response CCTO:000120 event_t CCTO:000121(time_t t0) = EVENT_STATE(CCTO:000121, t0) cancer_care_treatment_outcome CCTO:000121 Acute toxicity CCTO:000121 CCTO:000122 = time-to-first CCTO:000114 CCTO:000058 duration_t CCTO:000122(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000058) ) cancer_care_treatment_outcome Distant metastases free survival Distant metastasis-free survival CCTO:000122 Distant disease-free survival CCTO:000122 Morbidity; the relative incidence of a particular disease in a population. type_t CCTO:000123(time_t t0) = EVENT_STATE(CCTO:000123, t0) NCIT:C16877 UMLS:C0026538 cancer_care_treatment_outcome CCTO:000123 Morbidity CCTO:000123 Morbidity; the relative incidence of a particular disease in a population. NCIT:C16877 CCTO:000124 implies CCTO:000098 event_t CCTO:000124(time_t t0) = EVENT_STATE(CCTO:000124, t0) UMLS:C0032787 cancer_care_treatment_outcome Post-operative complications Postoperative complication CCTO:000124 Postoperative complications CCTO:000124 duration_t CCTO:000125(time_t t0) = duration_of_event(CCTO:000073, t0) cancer_care_treatment_outcome CCTO:000125 Duration of disease control CCTO:000125 probability_t CCTO:000126(time_t t0, time_t assessed_at) = probability(CCTO:000081(t0, assessed_at) == TRUE, assessed_at) cancer_care_treatment_outcome Relapse rates CCTO:000126 Relapse rate CCTO:000126 probability_t CCTO:000127(time_t t0, time_t assessed_at) = probability(CCTO:000088(t0, assessed_at) == TRUE, assessed_at) cancer_care_treatment_outcome Complete pathological response rate Pathological complete response rate pCR rate CCTO:000127 Pathologic complete response rate CCTO:000127 Overall tiredness and lack of energy OR A disorder characterized by a state of generalized weakness with a pronounced inability to summon sufficient energy to accomplish daily activities. CCTO:000128 implies CCTO:000049 CCTO:000128 implies CCTO:001103 NCI:CTCAE:10016256 NCIT:C3036 UMLS:C0015672 Lack of Energy cancer_care_treatment_outcome CCTO:000128 Fatigue CCTO:000128 Overall tiredness and lack of energy OR A disorder characterized by a state of generalized weakness with a pronounced inability to summon sufficient energy to accomplish daily activities. NCI:CTCAE NCIT:C3036 Lack of Energy NCIT:C3036 A disorder resulting from the presence and activity of a microbial, viral, fungal, or parasitic agent. It can be transmitted by direct or indirect contact. CCTO:000129 implies CCTO:000043 event_t CCTO:000129(time_t t0) = EVENT_STATE(CCTO:000129, t0) NCIT:C26726 UMLS:C0009450 UMLS:C1550587 UMLS:C3714514 UMLS:C3714515 Infection Infectious Infectious Diseases and Manifestations Infectious disease Infectious disorder cancer_care_treatment_outcome CCTO:000129 Infections CCTO:000129 A disorder resulting from the presence and activity of a microbial, viral, fungal, or parasitic agent. It can be transmitted by direct or indirect contact. NCIT:C26726 Infection NCIT:C26726 Infectious NCIT:C26726 Infectious Diseases and Manifestations NCIT:C26726 Infectious disease NCIT:C26726 Infectious disorder NCIT:C26726 CCTO:000130 implies CCTO:000043 CCTO:000130 implies CCTO:000107 CCTO:000130 implies NOT CCTO:000178 CCTO:000130 implies NOT CCTO:000257 CCTO:000130 implies NOT CCTO:000340 event_t CCTO:000130(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000130, t0, assessed_at) cancer_care_treatment_outcome CCTO:000130 Pain progression CCTO:000130 CCTO:000131 = time-to-first CCTO:000130 duration_t CCTO:000131(time_t t0) = time_to_first_event(CCTO:000130, t0) cancer_care_treatment_outcome CCTO:000131 Time to pain progression CCTO:000131 probability_t CCTO:000132(time_t t0) = probability(CCTO:000120, t0) cancer_care_treatment_outcome CCTO:000132 PSA response rate CCTO:000132 event_t CCTO:000133(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000133, t0, assessed_at) cancer_care_treatment_outcome Symptomatic benefit CCTO:000133 Clinical benefit response CCTO:000133 An abatement in intensity or degree (as in the manifestations of a disease). CCTO:000082 implies CCTO:000134 CCTO:000134 is-union-of CCTO:000082 CCTO:000201 CCTO:000201 implies CCTO:000134 event_t CCTO:000134(time_t t0) = EVENT_STATE(CCTO:000134, t0) NCIT:C18246 UMLS:C0544452 UMLS:C0687702 cancer_care_treatment_outcome Overall remission CCTO:000134 Remission CCTO:000134 An abatement in intensity or degree (as in the manifestations of a disease). NCIT:C18246 CCTO:000135 = measured-from CCTO:000054 CCTO:000067 duration_t CCTO:000135(time_t t0) = duration_of_event(CCTO:000134, t0) cancer_care_treatment_outcome Remission duration CCTO:000135 Duration of remission CCTO:000135 event_t CCTO:000136(time_t t0) = EVENT_STATE(CCTO:000136, t0) cancer_care_treatment_outcome late toxicities CCTO:000136 Late toxicity CCTO:000136 Any disease or disorder that occurs during the course of, or because of, another disease, treatment, or procedure. CCTO:000137 implies CCTO:001120 event_t CCTO:000137(time_t t0) = EVENT_STATE(CCTO:000137, t0) NCIT:C2959 UMLS:C0009566 UMLS:C0802632 Complication cancer_care_treatment_outcome CCTO:000137 Complications CCTO:000137 Any disease or disorder that occurs during the course of, or because of, another disease, treatment, or procedure. NCIT:C2959 Complication NCIT:C2959 CCTO:000138 = time-to-first CCTO:000114 CCTO:000139 duration_t CCTO:000138(time_t t0) = min( time_to_first_event(t0, CCTO:000291), time_to_first_event(t0, CCTO:000087), time_to_first_event(t0, CCTO:000153), time_to_first_event(t0, CCTO:001104), time_to_first_event(t0, CCTO:000215), time_to_first_event(t0, CCTO:000114) ) cancer_care_treatment_outcome CCTO:000138 Invasive disease-free survival CCTO:000138 CCTO:000087 implies CCTO:000139 CCTO:000139 implies CCTO:000070 CCTO:000139 is-union-of CCTO:000087 CCTO:000153 CCTO:001104 CCTO:000215 CCTO:000153 implies CCTO:000139 CCTO:000215 implies CCTO:000139 CCTO:001104 implies CCTO:000139 event_t NULL cancer_care_treatment_outcome CCTO:000139 Invasive disease CCTO:000139 CCTO:000140 = time-to-first CCTO:000081 duration_t CCTO:000140(time_t t0) = time_to_first_event(CCTO:000081, t0) cancer_care_treatment_outcome CCTO:000140 Time to relapse CCTO:000140 A general indicator of the body fat an individual is carrying based upon the ratio of weight to height. CCTO:000141 implies CCTO:000043 event_t CCTO:000141(time_t t0) = EVENT_STATE(CCTO:000141, t0) NCIT:C16358 UMLS:C0005893 UMLS:C1305855 UMLS:C1542867 UMLS:C2240399 BMI Quetelet Index cancer_care_treatment_outcome CCTO:000141 Body Mass Index CCTO:000141 A general indicator of the body fat an individual is carrying based upon the ratio of weight to height. NCIT:C16358 BMI NCIT:C16358 Quetelet Index NCIT:C16358 A scanning procedure used to measure calcium and other minerals present in bone. CCTO:000142 implies CCTO:000043 CCTO:000142 implies CCTO:000051 unknown_t CCTO:000142(time_t t0) = EVENT_STATE(CCTO:000142, t0) NCIT:C61545 UMLS:C0005938 UMLS:C0177804 BMD Bone density test Bone mineral density test bone density bone mass cancer_care_treatment_outcome CCTO:000142 Bone mineral density CCTO:000142 A scanning procedure used to measure calcium and other minerals present in bone. NCIT:C61545 BMD NCIT:C61545 Bone density test NCIT:C61545 Bone mineral density test NCIT:C61545 bone density NCIT:C61545 bone mass NCIT:C61545 probability_t CCTO:000143(time_t t0, time_t assessed_at) = probability(CCTO:000069(t0), assessed_at) cancer_care_treatment_outcome CCTO:000143 Disease free survival rate CCTO:000143 CCTO:000144 implies NOT CCTO:000064 CCTO:000144 implies NOT CCTO:000147 NOT CCTO:000144 implies CCTO:000064 event_t CCTO:000144(time_t t0, time_t assessed_at) = NOT CCTO:000064(t0, assessed_at) cancer_care_treatment_outcome Freedom from progression CCTO:000144 Progression-free CCTO:000144 CCTO:000145 implies CCTO:000048 CCTO:000145 implies CCTO:000049 event_t CCTO:000145(time_t t0) = EVENT_STATE(CCTO:000145, t0) cancer_care_treatment_outcome Treatment related toxicities CCTO:000145 Treatment related toxicity CCTO:000145 duration_t CCTO:000146(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000147) ) cancer_care_treatment_outcome CCTO:000146 Local progression-free survival CCTO:000146 CCTO:000147 implies CCTO:000056 CCTO:000147 implies CCTO:000064 CCTO:000147 implies NOT CCTO:000106 CCTO:000147 implies NOT CCTO:000144 event_t CCTO:000147(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000147, t0, assessed_at) cancer_care_treatment_outcome CCTO:000147 Local progression CCTO:000147 An evaluation of the pathologic response of the disease to the therapy. event_t CCTO:000148(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000148, t0, assessed_at) NCIT:C123626 PATHRESP Pathologic response cancer_care_treatment_outcome CCTO:000148 Pathological response CCTO:000148 An evaluation of the pathologic response of the disease to the therapy. NCIT:C123626 PATHRESP NCIT:C123626 Pathologic response NCIT:C123626 probability_t CCTO:000149(time_t t0, time_t assessed_at) = probability(CCTO:000148(t0, assessed_at) == TRUE, assessed_at) cancer_care_treatment_outcome Pathologic response rate CCTO:000149 Pathological response rate CCTO:000149 The condition of being treated as a patient in a hospital. event_t CCTO:000150(time_t t0) = EVENT_STATE(CCTO:000150, t0) NCIT:C25179 UMLS:C0019993 UMLS:C3489408 Hospitalization cancer_care_treatment_outcome CCTO:000150 Hospital stay CCTO:000150 The condition of being treated as a patient in a hospital. NCIT:C25179 Hospitalization NCIT:C25179 Any expected or unexpected adverse event, related or unrelated to the intervention, occurring at any agent dose, any phase of product or procedure testing, that results in any of the following outcomes: death, a life-threatening adverse event, requires inpatient hospitalization (not required as part of the treatment) or prolongation of existing hospitalization, a persistent or significant disability or incapacity, or cancer, or a congenital anomaly or birth defect. Important medical events that may not result in the listed outcomes may be considered as serious when, based upon appropriate medical judgment, they represent significant hazards or potentially serious harm to the research subject or others and may require medical intervention to prevent one of the outcomes listed in this definition. CCTO:000151 implies CCTO:000049 event_t CCTO:000151(time_t t0) = EVENT_STATE(CCTO:000151, t0) NCIT:C41335 UMLS:C1519255 SAE Serious adverse event cancer_care_treatment_outcome Grade 3 Through 5 Adverse Events That Are Related to Study Drug Grade 3 Through Grade 5 Adverse Events That Are Related to Study Drug CCTO:000151 Serious adverse events CCTO:000151 Any expected or unexpected adverse event, related or unrelated to the intervention, occurring at any agent dose, any phase of product or procedure testing, that results in any of the following outcomes: death, a life-threatening adverse event, requires inpatient hospitalization (not required as part of the treatment) or prolongation of existing hospitalization, a persistent or significant disability or incapacity, or cancer, or a congenital anomaly or birth defect. Important medical events that may not result in the listed outcomes may be considered as serious when, based upon appropriate medical judgment, they represent significant hazards or potentially serious harm to the research subject or others and may require medical intervention to prevent one of the outcomes listed in this definition. NCIT:C41335 SAE NCIT:C41335 Serious adverse event NCIT:C41335 A sensation of discomfort secondary to surgery. CCTO:000152 implies CCTO:000098 CCTO:000152 implies CCTO:000107 event_t CCTO:000152(time_t t0) = EVENT_STATE(CCTO:000152, t0) NCIT:C34887 UMLS:C0030201 Post-operative pain cancer_care_treatment_outcome CCTO:000152 Postoperative pain CCTO:000152 A sensation of discomfort secondary to surgery. NCIT:C34887 Post-operative pain NCIT:C34887 CCTO:000153 implies CCTO:000056 CCTO:000153 implies CCTO:000087 CCTO:000153 implies CCTO:001131 CCTO:000153 implies NOT CCTO:000106 event_t CCTO:000153(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000153, t0, assessed_at) cancer_care_treatment_outcome CCTO:000153 Local recurrence CCTO:000153 probability_t CCTO:000154(time_t t0) = probability(CCTO:000153, t0) cancer_care_treatment_outcome CCTO:000154 Local recurrence rate CCTO:000154 event_t CCTO:000155(time_t t0) = EVENT_STATE(CCTO:000155, t0) cancer_care_treatment_outcome CCTO:000155 Complete resection CCTO:000155 probability_t CCTO:000156(time_t t0) = probability(CCTO:000155, t0) cancer_care_treatment_outcome CCTO:000156 Complete resection rate CCTO:000156 CCTO:000157 implies CCTO:000043 CCTO:000157 implies CCTO:000118 event_t CCTO:000157(time_t t0) = EVENT_STATE(CCTO:000157, t0) UMLS:C0582148 cancer_care_treatment_outcome Pain ratings Pain scores CCTO:000157 Pain score CCTO:000157 duration_t CCTO:000158(time_t t0) = EVENT_STATE(CCTO:000158, t0) UMLS:C3494201 cancer_care_treatment_outcome Operation time Procedure time CCTO:000158 Operative time CCTO:000158 CCTO:000159 implies NOT CCTO:000112 event_t CCTO:000159(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000159, t0, assessed_at) cancer_care_treatment_outcome CCTO:000159 Radiographic response CCTO:000159 duration_t CCTO:000160(time_t t0) = duration_of_event(CCTO:000078, t0) cancer_care_treatment_outcome CCTO:000160 Duration of clinical benefit CCTO:000160 probability_t CCTO:000161(time_t t0) = probability(CCTO:000137, t0) cancer_care_treatment_outcome Complication rates CCTO:000161 Complication rate CCTO:000161 CCTO:000162 = time-to-first CCTO:000114 CCTO:000153 duration_t CCTO:000162(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000153) ) cancer_care_treatment_outcome CCTO:000162 Local recurrence-free survival CCTO:000162 The act of cutting out; the surgical removal of part or all of a structure or organ. event_t CCTO:000163(time_t t0) = EVENT_STATE(CCTO:000163, t0) NCIT:C15232 UMLS:C0015252 UMLS:C0185115 UMLS:C0728940 UMLS:C1177284 Abscission Excision Excisional Extirpation Removal Surgical removal cancer_care_treatment_outcome CCTO:000163 Resection CCTO:000163 The act of cutting out; the surgical removal of part or all of a structure or organ. NCIT:C15232 Abscission NCIT:C15232 Excision NCIT:C15232 Excisional NCIT:C15232 Extirpation NCIT:C15232 Removal NCIT:C15232 Surgical removal NCIT:C15232 probability_t CCTO:000164(time_t t0) = probability(CCTO:000163, t0) cancer_care_treatment_outcome CCTO:000164 Resection rate CCTO:000164 probability_t CCTO:000165(time_t t0) = probability(CCTO:000144, t0) cancer_care_treatment_outcome CCTO:000165 Progression-free rate CCTO:000165 CCTO:000166 implies CCTO:000049 event_t CCTO:000166(time_t t0) = EVENT_STATE(CCTO:000166, t0) NCIT:C12788 UMLS:C0037253 UMLS:C0521324 UMLS:C0816871 UMLS:C3540776 Skeletal system Skeleton skeletal cancer_care_treatment_outcome Skeletal-related events CCTO:000166 Skeletal-related event CCTO:000166 Skeletal system NCIT:C12788 Skeleton NCIT:C12788 skeletal NCIT:C12788 CCTO:000167 = time-to-first CCTO:000166 duration_t CCTO:000167(time_t t0) = time_to_first_event(CCTO:000166, t0) cancer_care_treatment_outcome CCTO:000167 Time to first skeletal-related event CCTO:000167 CCTO:000168 implies NOT CCTO:000087 NOT CCTO:000168 implies CCTO:000087 event_t CCTO:000168(time_t t0, time_t assessed_at) = NOT CCTO:000087(t0, assessed_at) cancer_care_treatment_outcome CCTO:000168 Recurrence-free CCTO:000168 event_t CCTO:000169(time_t t0) = EVENT_STATE(CCTO:000169, t0) cancer_care_treatment_outcome cosmetic results CCTO:000169 Cosmetic outcome CCTO:000169 CCTO:000170 = time-to-first CCTO:000153 duration_t CCTO:000170(time_t t0) = time_to_first_event(CCTO:000153, t0) cancer_care_treatment_outcome CCTO:000170 Time to local recurrence CCTO:000170 CCTO:000171 implies CCTO:000106 CCTO:000171 implies CCTO:001133 CCTO:000171 implies NOT CCTO:000211 CCTO:000171 implies NOT CCTO:001131 CCTO:000171 is-intersection-of CCTO:000106 CCTO:001133 NOT CCTO:000106 implies NOT CCTO:000171 NOT CCTO:001133 implies NOT CCTO:000171 event_t CCTO:000171(time_t t0) = EVENT_STATE(CCTO:000171, t0) cancer_care_treatment_outcome Loco-regional control Locoregional control CCTO:000171 Local-regional control CCTO:000171 A question about the intensity of an individual's pain. CCTO:000172 implies CCTO:000043 CCTO:000172 implies CCTO:000118 event_t CCTO:000172(time_t t0) = EVENT_STATE(CCTO:000172, t0) NCIT:C124175 UMLS:C1320357 UMLS:C1507013 Pain distress Pain severity Severity of Pain cancer_care_treatment_outcome CCTO:000172 Pain intensity CCTO:000172 A question about the intensity of an individual's pain. NCIT:C124175 Pain distress NCIT:C124175 Pain severity NCIT:C124175 Severity of Pain NCIT:C124175 duration_t CCTO:000173(time_t t0) = duration_of_event(CCTO:000120, t0) cancer_care_treatment_outcome CCTO:000173 Duration of PSA response CCTO:000173 duration_t CCTO:000174(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000175) ) cancer_care_treatment_outcome CCTO:000174 Clinical progression-free survival CCTO:000174 CCTO:000175 implies NOT CCTO:000092 event_t CCTO:000175(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000175, t0, assessed_at) cancer_care_treatment_outcome CCTO:000175 Clinical progression CCTO:000175 CCTO:000176 = measured-from-first CCTO:000082 time-to-first-not CCTO:000082 duration_t CCTO:000176(time_t t0) = duration_of_event(CCTO:000082, t0) cancer_care_treatment_outcome CCTO:000176 Duration of complete response CCTO:000176 Loss of blood from the circulation, either internally or externally. CCTO:000177 implies CCTO:000098 event_t CCTO:000177(time_t t0) = EVENT_STATE(CCTO:000177, t0) NCIT:C50470 UMLS:C0553700 UMLS:C1443559 UMLS:C3163616 Loss of blood cancer_care_treatment_outcome Estimated blood loss CCTO:000177 Blood loss CCTO:000177 Loss of blood from the circulation, either internally or externally. NCIT:C50470 Loss of blood NCIT:C50470 CCTO:000178 implies CCTO:000043 CCTO:000178 implies NOT CCTO:000130 event_t CCTO:000178(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000178, t0, assessed_at) UMLS:C0424543 cancer_care_treatment_outcome CCTO:000178 Pain response CCTO:000178 CCTO:000179 implies CCTO:000098 event_t CCTO:000179(time_t t0) = EVENT_STATE(CCTO:000179, t0) UMLS:C0221082 cancer_care_treatment_outcome CCTO:000179 Surgical complications CCTO:000179 CCTO:000180 implies CCTO:000043 CCTO:000180 implies CCTO:000118 event_t CCTO:000180(time_t t0) = EVENT_STATE(CCTO:000180, t0) cancer_care_treatment_outcome CCTO:000180 Hospital Anxiety and Depression Scale CCTO:000180 event_t CCTO:000181(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000181, t0, assessed_at) cancer_care_treatment_outcome Symptom progression CCTO:000181 Symptomatic progression CCTO:000181 duration_t CCTO:000182(time_t t0) = time_to_first_event(CCTO:000181, t0) cancer_care_treatment_outcome Time to Symptom Progression CCTO:000182 Time to symptomatic progression CCTO:000182 probability_t CCTO:000183(time_t t0, time_t assessed_at) = probability(CCTO:000064(t0, assessed_at) == TRUE, assessed_at) cancer_care_treatment_outcome CCTO:000183 Progression rate CCTO:000183 probability_t CCTO:000184(time_t t0) = probability(CCTO:000048, t0) cancer_care_treatment_outcome Overall toxicity rate Toxicity rates CCTO:000184 Toxicity rate CCTO:000184 CCTO:000185 implies CCTO:000043 CCTO:000185 implies CCTO:000118 event_t CCTO:000185(time_t t0) = EVENT_STATE(CCTO:000185, t0) cancer_care_treatment_outcome CCTO:000185 Positive and Negative Affect Schedule CCTO:000185 event_t CCTO:000186(time_t t0) = EVENT_STATE(CCTO:000186, t0) cancer_care_treatment_outcome CCTO:000186 Complete clearance CCTO:000186 probability_t CCTO:000187(time_t t0) = probability(CCTO:000186, t0) cancer_care_treatment_outcome CCTO:000187 Complete clearance rate CCTO:000187 A melancholy feeling of sadness and despair OR A disorder characterized by melancholic feelings of grief or unhappiness. CCTO:000188 implies CCTO:000049 CCTO:000188 implies CCTO:001105 NCI:CTCAE:10012378 NCIT:C2982 UMLS:C0011570 UMLS:C0011581 UMLS:C1999266 cancer_care_treatment_outcome CCTO:000188 Depression CCTO:000188 A melancholy feeling of sadness and despair OR A disorder characterized by melancholic feelings of grief or unhappiness. NCI:CTCAE NCIT:C2982 CCTO:000189 = time-to-first CCTO:000114 CCTO:000190 duration_t CCTO:000189(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000190) ) cancer_care_treatment_outcome CCTO:000189 Distant failure-free survival CCTO:000189 CCTO:000190 implies CCTO:000058 event_t CCTO:000190(time_t t0) = EVENT_STATE(CCTO:000190, t0) cancer_care_treatment_outcome CCTO:000190 Distant failure CCTO:000190 CCTO:000191 implies CCTO:000098 event_t NULL cancer_care_treatment_outcome Operative morbidity Post-operative morbidity Postoperative morbidity CCTO:000191 Surgical morbidity CCTO:000191 An index designed for classifying patients 16 years of age or older by their functional impairment. event_t CCTO:000192(time_t t0) = EVENT_STATE(CCTO:000192, t0) NCIT:C28013 UMLS:C0206065 KPS Karnofsky Karnofsky scale cancer_care_treatment_outcome Karnofsky Performance Scale CCTO:000192 Karnofsky Performance Status CCTO:000192 An index designed for classifying patients 16 years of age or older by their functional impairment. NCIT:C28013 KPS NCIT:C28013 Karnofsky NCIT:C28013 Karnofsky scale NCIT:C28013 probability_t CCTO:000193(time_t t0) = probability(CCTO:000134, t0) cancer_care_treatment_outcome Remission rate CCTO:000193 Overall remission rate CCTO:000193 CCTO:000194 implies CCTO:000118 event_t CCTO:000194(time_t t0) = EVENT_STATE(CCTO:000194, t0) UMLS:C3476431 cancer_care_treatment_outcome Quality of life score CCTO:000194 Quality of life questionnaire CCTO:000194 CCTO:000195 = time-to-first CCTO:000114 CCTO:000196 duration_t CCTO:000195(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000196) ) cancer_care_treatment_outcome CCTO:000195 Immune-related progression-free survival CCTO:000195 Protected against infectious disease by either specific or non-specific mechanisms. CCTO:000196 implies CCTO:000064 CCTO:000196 implies NOT CCTO:000344 event_t NULL NCIT:C17997 UMLS:C0439662 Immune cancer_care_treatment_outcome CCTO:000196 Immune-related progression CCTO:000196 Protected against infectious disease by either specific or non-specific mechanisms. NCIT:C17997 Immune NCIT:C17997 event_t CCTO:000197(time_t t0) = EVENT_STATE(CCTO:000197, t0) cancer_care_treatment_outcome CCTO:000197 Resectability CCTO:000197 probability_t CCTO:000198(time_t t0) = probability(CCTO:000197, t0) cancer_care_treatment_outcome CCTO:000198 Resectability rate CCTO:000198 event_t CCTO:000199(time_t t0) = EVENT_STATE(CCTO:000199, t0) cancer_care_treatment_outcome CCTO:000199 Breast conservation CCTO:000199 probability_t CCTO:000200(time_t t0) = probability(CCTO:000199, t0) cancer_care_treatment_outcome CCTO:000200 Breast conservation rate CCTO:000200 A finding indicating that there is a decrease in the size and the extent of tissue involvement by a malignant tumor in a patient. CCTO:000201 implies CCTO:000065 CCTO:000201 implies CCTO:000070 CCTO:000201 implies NOT CCTO:000064 CCTO:000201 implies NOT CCTO:000082 CCTO:000201 implies NOT CCTO:000099 event_t CCTO:000201(time_t t0) = EVENT_STATE(CCTO:000201, t0) event_t CCTO:000201(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000201, t0, assessed_at) NCIT:C18058 NCIT:C18212 UMLS:C1521726 Partial remission cancer_care_treatment_outcome CCTO:000201 Partial response CCTO:000201 A finding indicating that there is a decrease in the size and the extent of tissue involvement by a malignant tumor in a patient. NCIT:C18058 Partial remission NCIT:C18058 CCTO:000202 = time-to-first CCTO:000175 duration_t CCTO:000202(time_t t0) = time_to_first_event(CCTO:000175, t0) cancer_care_treatment_outcome CCTO:000202 Time to clinical progression CCTO:000202 duration_t CCTO:000203(time_t t0) = time_to_first_event(CCTO:000089, t0) cancer_care_treatment_outcome CCTO:000203 Time to best response CCTO:000203 event_t CCTO:000204(time_t t0) = EVENT_STATE(CCTO:000204, t0) cancer_care_treatment_outcome CCTO:000204 Partial clearance CCTO:000204 probability_t CCTO:000205(time_t t0) = probability(CCTO:000204, t0) cancer_care_treatment_outcome CCTO:000205 Partial clearance rate CCTO:000205 A symptom or state of reduced quality or strength. event_t CCTO:000206(time_t t0) = EVENT_STATE(CCTO:000206, t0) NCIT:C25751 UMLS:C0868945 cancer_care_treatment_outcome CCTO:000206 Deterioration CCTO:000206 A symptom or state of reduced quality or strength. NCIT:C25751 duration_t CCTO:000207(time_t t0) = time_to_first_event(CCTO:000206, t0) cancer_care_treatment_outcome CCTO:000207 Time to deterioration CCTO:000207 probability_t CCTO:000208(time_t t0, time_t assessed_at) = probability(CCTO:000071(t0), assessed_at) cancer_care_treatment_outcome CCTO:000208 Event-free survival rate CCTO:000208 The vertical force exerted by a mass as a result of gravity OR The relative importance granted to something. CCTO:000209 implies CCTO:000043 event_t CCTO:000209(time_t t0) = EVENT_STATE(CCTO:000209, t0) NCIT:C25208 NCIT:C48192 UMLS:C0005910 UMLS:C0043100 UMLS:C0944911 UMLS:C1305866 UMLS:C1705104 Importance weight weighting cancer_care_treatment_outcome CCTO:000209 Weight CCTO:000209 The vertical force exerted by a mass as a result of gravity OR The relative importance granted to something. NCIT:C25208 NCIT:C48192 Importance weight NCIT:C48192 weighting NCIT:C48192 CCTO:000210 = time-to-first CCTO:000114 CCTO:000211 duration_t CCTO:000210(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000211) ) cancer_care_treatment_outcome CCTO:000210 Locoregional failure-free survival CCTO:000210 CCTO:000153 implies CCTO:000211 CCTO:000211 implies NOT CCTO:000171 CCTO:000211 is-union-of CCTO:000153 CCTO:001104 CCTO:001104 implies CCTO:000211 event_t CCTO:000211(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000211, t0, assessed_at) cancer_care_treatment_outcome Local-regional failure CCTO:000211 Locoregional failure CCTO:000211 Red discoloration of the skin caused by infectious agents, inflammation, drug hypersensitivity, or underlying disease. CCTO:000212 implies CCTO:000049 event_t CCTO:000212(time_t t0) = EVENT_STATE(CCTO:000212, t0) NCIT:C26901 UMLS:C0041834 UMLS:C0332575 UMLS:C1260956 Redness cancer_care_treatment_outcome CCTO:000212 Erythema CCTO:000212 Red discoloration of the skin caused by infectious agents, inflammation, drug hypersensitivity, or underlying disease. NCIT:C26901 Redness NCIT:C26901 A substance present in or produced by a tumor or by the host, that can be used for differentiating neoplastic from normal tissue based on measurements in body fluids, secretions, cells, and/or tissues. Markers are used in diagnosis, staging and prognosis of cancer, provide an estimation of tumor burden, and serve for monitoring effects of therapy, detecting recurrence, localization of tumors, and screening in general populations. CCTO:000213 implies CCTO:000051 event_t CCTO:000213(time_t t0) = EVENT_STATE(CCTO:000213, t0) NCIT:C17220 UMLS:C0041365 UMLS:C1139415 Tumor marker cancer_care_treatment_outcome CCTO:000213 Tumor markers CCTO:000213 A substance present in or produced by a tumor or by the host, that can be used for differentiating neoplastic from normal tissue based on measurements in body fluids, secretions, cells, and/or tissues. Markers are used in diagnosis, staging and prognosis of cancer, provide an estimation of tumor burden, and serve for monitoring effects of therapy, detecting recurrence, localization of tumors, and screening in general populations. NCIT:C17220 Tumor marker NCIT:C17220 event_t CCTO:000214(time_t t0, time_t assessed_at) = NOT CCTO:000215(t0, assessed_at) cancer_care_treatment_outcome CCTO:000214 Distant recurrence-free CCTO:000214 CCTO:000215 implies CCTO:000058 CCTO:000215 implies CCTO:000087 CCTO:000215 implies CCTO:000190 event_t CCTO:000215(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000215, t0, assessed_at) cancer_care_treatment_outcome CCTO:000215 Distant recurrence CCTO:000215 duration_t CCTO:000216(time_t t0) = time_to_first_event(CCTO:000215, t0) cancer_care_treatment_outcome CCTO:000216 Distant recurrence-free interval CCTO:000216 A psychometric response scale to assess subjective characteristics or symptoms, which relies upon a continuum of possible result values in between two fixed end-points. CCTO:000217 implies CCTO:000043 CCTO:000217 implies CCTO:000118 event_t CCTO:000217(time_t t0) = EVENT_STATE(CCTO:000217, t0) NCIT:C121547 UMLS:C0042815 UMLS:C3536884 VAS Visual analog scale cancer_care_treatment_outcome CCTO:000217 Visual analogue scale CCTO:000217 A psychometric response scale to assess subjective characteristics or symptoms, which relies upon a continuum of possible result values in between two fixed end-points. NCIT:C121547 VAS NCIT:C121547 Visual analog scale NCIT:C121547 CCTO:000218 implies CCTO:000073 CCTO:000218 implies CCTO:000106 CCTO:000218 implies CCTO:001133 CCTO:000218 implies NOT CCTO:000056 CCTO:000218 implies NOT CCTO:000057 CCTO:000218 implies NOT CCTO:000058 CCTO:000218 implies NOT CCTO:000070 NOT CCTO:000218 implies CCTO:000070 event_t CCTO:000218(time_t t0) = NOT EVENT_STATE(CCTO:000070, t0) cancer_care_treatment_outcome CCTO:000218 Disease-free CCTO:000218 CCTO:000219 = measured-from-first CCTO:000218 time-to-first CCTO:000070 duration_t CCTO:000219(time_t t0) = time_to_first_event(CCTO:000070, t0) cancer_care_treatment_outcome CCTO:000219 Disease-free interval CCTO:000219 probability_t CCTO:000220(time_t t0, time_t assessed_at) = probability(CCTO:000201(t0, assessed_at) == TRUE, assessed_at) cancer_care_treatment_outcome CCTO:000220 Partial response rate CCTO:000220 probability_t CCTO:000221(time_t t0) = probability(CCTO:000099, t0) cancer_care_treatment_outcome CCTO:000221 Stable disease rate CCTO:000221 CCTO:000222 = time-to-first CCTO:000114 CCTO:000223 duration_t CCTO:000222(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000223) ) cancer_care_treatment_outcome CCTO:000222 Treatment-free survival CCTO:000222 A period in a clinical study during which subjects receive therapeutic treatment OR An action or administration of therapeutic agents to produce an effect that is intended to alter or stop a pathologic process OR The act of the dispensing, applying, or tendering of something to another, such as administration of a medicine OR Subject to a process with the aim of readying for some purpose, improving, or remedying a condition OR An action or administration of therapeutic agents to produce an effect that is intended to alter the course of a pathologic process. event_t CCTO:000223(time_t t0) = EVENT_STATE(CCTO:000223, t0) NCIT:C101526 NCIT:C15368 NCIT:C25409 NCIT:C49236 NCIT:C70742 UMLS:C0001554 UMLS:C0039798 UMLS:C0087111 UMLS:C0808232 UMLS:C1292734 UMLS:C1522326 UMLS:C1705169 UMLS:C3161471 UMLS:C3538994 Administration TX Therapeutic interventions Therapeutic method Therapeutic procedure Therapeutic technique Therapy Treat Treated Treatment Treatment epoch cancer_care_treatment_outcome CCTO:000223 On treatment CCTO:000223 A period in a clinical study during which subjects receive therapeutic treatment OR An action or administration of therapeutic agents to produce an effect that is intended to alter or stop a pathologic process OR The act of the dispensing, applying, or tendering of something to another, such as administration of a medicine OR Subject to a process with the aim of readying for some purpose, improving, or remedying a condition OR An action or administration of therapeutic agents to produce an effect that is intended to alter the course of a pathologic process. NCIT:C101526 NCIT:C15368 NCIT:C25409 NCIT:C49236 NCIT:C70742 Administration NCIT:C25409 TX NCIT:C15368 TX NCIT:C49236 Therapeutic interventions NCIT:C15368 Therapeutic interventions NCIT:C49236 Therapeutic method NCIT:C49236 Therapeutic procedure NCIT:C15368 Therapeutic procedure NCIT:C49236 Therapeutic technique NCIT:C49236 Therapy NCIT:C15368 Therapy NCIT:C49236 Treat NCIT:C70742 Treated NCIT:C70742 Treatment NCIT:C15368 Treatment NCIT:C25409 Treatment NCIT:C49236 Treatment NCIT:C70742 Treatment epoch NCIT:C101526 CCTO:000224 = time-to-first CCTO:001106 duration_t CCTO:000224(time_t t0) = EVENT_STATE(CCTO:001106, t0) ? CCTO:000062(t0) : NULL cancer_care_treatment_outcome CCTO:000224 Prostate cancer-specific survival CCTO:000224 CCTO:000225 implies CCTO:000049 unknown_t CCTO:000225(time_t t0) = EVENT_STATE(CCTO:000225, t0) UMLS:C0815107 cancer_care_treatment_outcome CCTO:000225 Psychological distress CCTO:000225 Accumulation of an excessive amount of fluid in cells or intercellular tissues. CCTO:000226 implies CCTO:000049 event_t CCTO:000226(time_t t0) = EVENT_STATE(CCTO:000226, t0) NCIT:C3002 UMLS:C0013604 UMLS:C1717255 cancer_care_treatment_outcome CCTO:000226 Edema CCTO:000226 Accumulation of an excessive amount of fluid in cells or intercellular tissues. NCIT:C3002 event_t CCTO:000227(time_t t0) = EVENT_STATE(CCTO:000227, t0) cancer_care_treatment_outcome CCTO:000227 Early late toxicity CCTO:000227 CCTO:000228 implies CCTO:000118 event_t CCTO:000228(time_t t0) = EVENT_STATE(CCTO:000228, t0) cancer_care_treatment_outcome CCTO:000228 Dermatology Life Quality Index CCTO:000228 Any of the mental or physical manifestations that accompany perimenopause and menopause. CCTO:000229 implies CCTO:000049 event_t CCTO:000229(time_t t0) = EVENT_STATE(CCTO:000229, t0) NCIT:C3852 UMLS:C0236075 Menopausal symptom cancer_care_treatment_outcome CCTO:000229 Menopausal symptoms CCTO:000229 Any of the mental or physical manifestations that accompany perimenopause and menopause. NCIT:C3852 Menopausal symptom NCIT:C3852 A tool for the assessment of pain in both clinical and research settings. The BPI uses simple numeric rating scales from 0 to 10 that are easy to understand and easy to translate into other languages. On the BPI, mild pain is defined as a worst pain score of 1 - 4, moderate pain is defined as a worst pain score of 5 - 6, and severe pain is defined as a worst pain score of 7-10 OR A standardized survey originally developed and copyrighted by Charles S. Cleeland in 1991 which is used to evaluate the severity of a patient's pain and the impact that their pain has on their daily activities. This longer version is more clinically useful, can be completed by the patient or in an interview format and consists of 32 multi-level questions covering areas such as location, type, and severity of pain as well as the use of pain medications. CCTO:000230 implies CCTO:000043 CCTO:000230 implies CCTO:000118 event_t CCTO:000230(time_t t0) = EVENT_STATE(CCTO:000230, t0) NCIT:C100759 NCIT:C18203 UMLS:C1443145 UMLS:C1511326 UMLS:C3539024 BPI BPI1 Brief Pain Inventory Questionnaire cancer_care_treatment_outcome CCTO:000230 Brief Pain Inventory CCTO:000230 A tool for the assessment of pain in both clinical and research settings. The BPI uses simple numeric rating scales from 0 to 10 that are easy to understand and easy to translate into other languages. On the BPI, mild pain is defined as a worst pain score of 1 - 4, moderate pain is defined as a worst pain score of 5 - 6, and severe pain is defined as a worst pain score of 7-10 OR A standardized survey originally developed and copyrighted by Charles S. Cleeland in 1991 which is used to evaluate the severity of a patient's pain and the impact that their pain has on their daily activities. This longer version is more clinically useful, can be completed by the patient or in an interview format and consists of 32 multi-level questions covering areas such as location, type, and severity of pain as well as the use of pain medications. NCIT:C100759 NCIT:C18203 BPI NCIT:C100759 BPI1 NCIT:C100759 Brief Pain Inventory Questionnaire NCIT:C100759 A reduction in total body weight OR A question about the usual severity of an individual's weight loss OR A question about how often an individual has or had weight loss OR A question about an individual's distress from their weight loss OR A finding characterized by a decrease in overall body weight; for pediatrics, less than the baseline growth curve OR A question about whether an individual has or had weight loss. CCTO:000231 implies CCTO:000049 CCTO:000231 implies CCTO:000051 NCI:CTCAE:10047900 NCIT:C125292 NCIT:C125324 NCIT:C125356 NCIT:C125411 NCIT:C3445 NCIT:C55339 UMLS:C0043096 UMLS:C2911645 Frequency of Weight Loss Have weight loss How much distress weight loss How often weight loss Usual severity weight loss Weight decrease Weight loss adverse event Weight loss frequency cancer_care_treatment_outcome CCTO:000231 Weight loss CCTO:000231 A reduction in total body weight OR A question about the usual severity of an individual's weight loss OR A question about how often an individual has or had weight loss OR A question about an individual's distress from their weight loss OR A finding characterized by a decrease in overall body weight; for pediatrics, less than the baseline growth curve OR A question about whether an individual has or had weight loss. NCI:CTCAE NCIT:C125292 NCIT:C125324 NCIT:C125356 NCIT:C125411 NCIT:C3445 Frequency of Weight Loss NCIT:C125292 Have weight loss NCIT:C125411 How much distress weight loss NCIT:C125356 How often weight loss NCIT:C125292 Usual severity weight loss NCIT:C125324 Weight decrease NCIT:C3445 Weight loss adverse event NCIT:C55339 Weight loss frequency NCIT:C125292 duration_t CCTO:000232(time_t t0) = time_to_first_event(CCTO:000072, t0) cancer_care_treatment_outcome CCTO:000232 Time to event CCTO:000232 CCTO:000233 = time-to-first CCTO:000103 duration_t CCTO:000233(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000103) ) cancer_care_treatment_outcome CCTO:000233 PSA progression free survival CCTO:000233 CCTO:000234 = time-to-first CCTO:000235 duration_t CCTO:000234(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000235) ) cancer_care_treatment_outcome CCTO:000234 Biochemical progression-free survival CCTO:000234 event_t NULL cancer_care_treatment_outcome CCTO:000235 Biochemical progression CCTO:000235 The disappearance of all signs of cancer based on physical exam, such as palpation. event_t CCTO:000236(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000236, t0, assessed_at) NCIT:C123574 UMLS:C1955905 Clinical complete remission cCR cancer_care_treatment_outcome CCTO:000236 Clinical complete response CCTO:000236 The disappearance of all signs of cancer based on physical exam, such as palpation. NCIT:C123574 Clinical complete remission NCIT:C123574 cCR NCIT:C123574 CCTO:000237 implies CCTO:000065 event_t CCTO:000237(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000237, t0, assessed_at) cancer_care_treatment_outcome CCTO:000237 Durable response CCTO:000237 probability_t CCTO:000238(time_t t0) = probability(CCTO:000237, t0) cancer_care_treatment_outcome CCTO:000238 Durable response rate CCTO:000238 A metastatic cancer cell found in the peripheral blood OR The determination of the amount of circulating tumor cells present in a sample. CCTO:000239 implies CCTO:000051 event_t CCTO:000239(time_t t0) = EVENT_STATE(CCTO:000239, t0) NCIT:C63797 NCIT:C96593 UMLS:C0027625 UMLS:C1516728 UMLS:C3272887 CTC Circulating tumor cell Circulating tumor cell count cancer_care_treatment_outcome Evidence of CTC CCTO:000239 circulating tumor cells Circulating tumor cells CCTO:000239 A metastatic cancer cell found in the peripheral blood OR The determination of the amount of circulating tumor cells present in a sample. NCIT:C63797 NCIT:C96593 CTC NCIT:C63797 CTC NCIT:C96593 Circulating tumor cell NCIT:C63797 Circulating tumor cell count NCIT:C96593 CCTO:000240 = time-to-first CCTO:000058 duration_t CCTO:000240(time_t t0) = time_to_first_event(CCTO:000058, t0) cancer_care_treatment_outcome CCTO:000240 Time to distant metastasis CCTO:000240 CCTO:000241 = time-to-first CCTO:000147 duration_t CCTO:000241(time_t t0) = time_to_first_event(CCTO:000147, t0) cancer_care_treatment_outcome CCTO:000241 Time to local progression CCTO:000241 CCTO:000242 implies CCTO:000043 CCTO:000242 implies CCTO:000051 unknown_t CCTO:000242(time_t t0) = EVENT_STATE(CCTO:000242, t0) cancer_care_treatment_outcome CCTO:000242 Endometrial thickness CCTO:000242 CCTO:000243 = time-to-first CCTO:000114 CCTO:000244 duration_t CCTO:000243(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000244) ) cancer_care_treatment_outcome CCTO:000243 Local relapse-free survival CCTO:000243 CCTO:000244 implies CCTO:000056 CCTO:000244 implies CCTO:000081 CCTO:000244 implies CCTO:000153 CCTO:000244 implies NOT CCTO:000106 event_t NULL cancer_care_treatment_outcome CCTO:000244 Local relapse CCTO:000244 event_t CCTO:000245(time_t t0) = EVENT_STATE(CCTO:000245, t0) cancer_care_treatment_outcome Dose limiting toxicity CCTO:000245 Dose-limiting toxicities CCTO:000245 event_t CCTO:000246(time_t t0) = EVENT_STATE(CCTO:000246, t0) cancer_care_treatment_outcome CCTO:000246 Long term toxicity CCTO:000246 CCTO:000247 implies CCTO:000098 event_t CCTO:000247(time_t t0) = EVENT_STATE(CCTO:000247, t0) cancer_care_treatment_outcome CCTO:000247 Perioperative morbidity CCTO:000247 CCTO:000248 implies CCTO:000043 CCTO:000248 implies CCTO:000118 event_t CCTO:000248(time_t t0) = EVENT_STATE(CCTO:000248, t0) cancer_care_treatment_outcome CCTO:000248 Hamilton depression scale CCTO:000248 probability_t CCTO:000249(time_t t0) = probability(CCTO:000096, t0) NCIT:C53346 NCIT:C53358 UMLS:C0026565 UMLS:C0205848 UMLS:C1108678 Death rate cancer_care_treatment_outcome CCTO:000249 Mortality rate CCTO:000249 Death rate NCIT:C53346 Those physical activities which are required for our daily existence. These include personal maintenance activities and activities for maintenance of our living space, as well as activities related to independent living. event_t CCTO:000250(time_t t0) = EVENT_STATE(CCTO:000250, t0) NCIT:C53291 UMLS:C0001288 ADL Activity of Daily Living Daily activity Household activity cancer_care_treatment_outcome CCTO:000250 Activities of daily living CCTO:000250 Those physical activities which are required for our daily existence. These include personal maintenance activities and activities for maintenance of our living space, as well as activities related to independent living. NCIT:C53291 ADL NCIT:C53291 Activity of Daily Living NCIT:C53291 Daily activity NCIT:C53291 Household activity NCIT:C53291 event_t CCTO:000251(time_t t0) = EVENT_STATE(CCTO:000251, t0) cancer_care_treatment_outcome CCTO:000251 Postoperative quality of life CCTO:000251 CCTO:000252 implies CCTO:000223 event_t CCTO:000252(time_t t0) = EVENT_STATE(CCTO:000252, t0) cancer_care_treatment_outcome CCTO:000252 Initiation of Cytotoxic Chemotherapy CCTO:000252 CCTO:000253 = time-to-first CCTO:000252 duration_t CCTO:000253(time_t t0) = time_to_first_event(CCTO:000252, t0) cancer_care_treatment_outcome CCTO:000253 Time to Initiation of Cytotoxic Chemotherapy CCTO:000253 CCTO:000254 implies CCTO:000098 event_t CCTO:000254(time_t t0) = EVENT_STATE(CCTO:000254, t0) cancer_care_treatment_outcome CCTO:000254 Intraoperative blood loss CCTO:000254 probability_t CCTO:000255(time_t t0) = probability(CCTO:000171, t0) cancer_care_treatment_outcome Local-regional control rate CCTO:000255 Locoregional control rate CCTO:000255 An evaluation of the hematologic response of the disease to the therapy. CCTO:000256 implies NOT CCTO:000341 event_t CCTO:000256(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000256, t0, assessed_at) NCIT:C123622 HEMARESP Hematologic response cancer_care_treatment_outcome CCTO:000256 Hematologic improvement CCTO:000256 An evaluation of the hematologic response of the disease to the therapy. NCIT:C123622 HEMARESP NCIT:C123622 Hematologic response NCIT:C123622 A lessening of pain following an intervention. CCTO:000257 implies CCTO:000043 CCTO:000257 implies CCTO:000178 CCTO:000257 implies NOT CCTO:000130 unknown_t NULL NCIT:C112216 UMLS:C0451615 cancer_care_treatment_outcome CCTO:000257 Pain relief CCTO:000257 A lessening of pain following an intervention. NCIT:C112216 probability_t CCTO:000258(time_t t0, time_t assessed_at) = probability(CCTO:000080(t0), assessed_at) cancer_care_treatment_outcome CCTO:000258 Relapse-free survival rate CCTO:000258 The collection of PROMIS item scales that assess perceived difficulties in intellectual processes, capabilities, and deficits. CCTO:000259 implies CCTO:000018 event_t CCTO:000259(time_t t0) = EVENT_STATE(CCTO:000259, t0) NCIT:C122365 UMLS:C0392335 Cognitive Function Item Bank Cognitive function subordinate domain cancer_care_treatment_outcome CCTO:000259 Cognitive function CCTO:000259 The collection of PROMIS item scales that assess perceived difficulties in intellectual processes, capabilities, and deficits. NCIT:C122365 Cognitive Function Item Bank NCIT:C122365 Cognitive function subordinate domain NCIT:C122365 Apprehension of danger and dread accompanied by restlessness, tension, tachycardia, and dyspnea unattached to a clearly identifiable stimulus OR A disorder characterized by apprehension of danger and dread accompanied by restlessness, tension, tachycardia, and dyspnea unattached to a clearly identifiable stimulus. CCTO:000260 implies CCTO:000049 CCTO:000260 implies CCTO:001105 NCI:CTCAE:10002855 NCIT:C26696 UMLS:C0003467 UMLS:C1963064 cancer_care_treatment_outcome CCTO:000260 Anxiety CCTO:000260 Apprehension of danger and dread accompanied by restlessness, tension, tachycardia, and dyspnea unattached to a clearly identifiable stimulus OR A disorder characterized by apprehension of danger and dread accompanied by restlessness, tension, tachycardia, and dyspnea unattached to a clearly identifiable stimulus. NCI:CTCAE NCIT:C26696 CCTO:000261 implies CCTO:000118 event_t CCTO:000261(time_t t0) = EVENT_STATE(CCTO:000261, t0) cancer_care_treatment_outcome CCTO:000261 Patient-reported quality of life CCTO:000261 CCTO:000262 implies CCTO:000049 event_t CCTO:000262(time_t t0) = EVENT_STATE(CCTO:000262, t0) cancer_care_treatment_outcome CCTO:000262 Residual erectile function CCTO:000262 A self-administered questionnaire designed to evaluate patient function and bother after prostate cancer treatment. CCTO:000263 implies CCTO:000118 unknown_t CCTO:000263(time_t t0) = EVENT_STATE(CCTO:000263, t0) NCIT:C107630 UMLS:C1273342 UMLS:C3810535 UMLS:C3810536 EPIC Expanded Prostate Cancer Index Composite (EPIC) cancer_care_treatment_outcome CCTO:000263 EPIC Expanded Prostate Cancer Index Composite CCTO:000263 A self-administered questionnaire designed to evaluate patient function and bother after prostate cancer treatment. NCIT:C107630 EPIC NCIT:C107630 Expanded Prostate Cancer Index Composite (EPIC) NCIT:C107630 A disorder characterized by loss of skin pigment OR Abnormal lightening of skin due to decreased melanin production or deposition. Vitiligo, albinism, and leukoderma are among the disorders that are associated with skin hypopigmentation. CCTO:000264 implies CCTO:000049 CCTO:000264 implies CCTO:001128 CCTO:000264 implies NOT CCTO:000267 CCTO:000264(time_t t0) = EVENT_STATE(CCTO:000264, t0) event_t CCTO:000264(time_t t0) = EVENT_STATE(CCTO:000264, t0) NCI:CTCAE:10040868 NCIT:C78610 UMLS:C0162835 UMLS:C1876214 UMLS:C1963139 Pigment dilution Skin hypopigmentation cancer_care_treatment_outcome CCTO:000264 Hypopigmentation CCTO:000264 A disorder characterized by loss of skin pigment OR Abnormal lightening of skin due to decreased melanin production or deposition. Vitiligo, albinism, and leukoderma are among the disorders that are associated with skin hypopigmentation. NCI:CTCAE NCIT:C78610 Pigment dilution NCIT:C78610 Skin hypopigmentation NCIT:C78610 event_t CCTO:000265(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000265, t0, assessed_at) cancer_care_treatment_outcome CCTO:000265 Biochemical response CCTO:000265 CCTO:000266 implies NOT CCTO:000181 event_t CCTO:000266(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000266, t0, assessed_at) cancer_care_treatment_outcome Symptom improvement CCTO:000266 Symptoms improvement CCTO:000266 A disorder characterized by darkening of the skin due to excessive melanin deposition OR Darkening of the skin due to excessive melanin deposition. Causes include skin injuries, pregnancy, eczema, and Addison disease. CCTO:000267 implies CCTO:000049 CCTO:000267 implies CCTO:001128 CCTO:000267 implies NOT CCTO:000264 CCTO:000267(time_t t0) = EVENT_STATE(CCTO:000267, t0) event_t CCTO:000267(time_t t0) = EVENT_STATE(CCTO:000267, t0) NCI:CTCAE:10040865 NCIT:C79731 UMLS:C0162834 UMLS:C1962962 Skin hyperpigmentation cancer_care_treatment_outcome CCTO:000267 Hyperpigmentation CCTO:000267 A disorder characterized by darkening of the skin due to excessive melanin deposition OR Darkening of the skin due to excessive melanin deposition. Causes include skin injuries, pregnancy, eczema, and Addison disease. NCI:CTCAE NCIT:C79731 Skin hyperpigmentation NCIT:C79731 CCTO:000268 implies CCTO:000043 event_t CCTO:000268(time_t t0) = EVENT_STATE(CCTO:000268, t0) cancer_care_treatment_outcome CCTO:000268 Modified ASEPSIS Scale CCTO:000268 CCTO:000269 implies CCTO:000043 event_t CCTO:000269(time_t t0) = EVENT_STATE(CCTO:000269, t0) cancer_care_treatment_outcome CCTO:000269 Surgical site infection score CCTO:000269 Symptomatic fracture, surgery or radiation to bone, or spinal cord compression CCTO:000270 implies CCTO:000166 event_t CCTO:000270(time_t t0) = EVENT_STATE(CCTO:000270, t0) cancer_care_treatment_outcome CCTO:000270 Symptomatic skeletal event CCTO:000270 Symptomatic fracture, surgery or radiation to bone, or spinal cord compression JClinOncol32:5s,2014(suppl;abstr5075) duration_t CCTO:000271(time_t t0) = time_to_first_event(CCTO:000270, t0) cancer_care_treatment_outcome CCTO:000271 Time to first symptomatic skeletal event CCTO:000271 Gas or air in the gastrointestinal tract. CCTO:000272 implies CCTO:000043 event_t CCTO:000272(time_t t0) = EVENT_STATE(CCTO:000272, t0) NCIT:C50569 UMLS:C0016204 cancer_care_treatment_outcome CCTO:000272 Flatus CCTO:000272 Gas or air in the gastrointestinal tract. NCIT:C50569 CCTO:000273 = time-to-first CCTO:000272 duration_t CCTO:000273(time_t t0) = time_to_first_event(CCTO:000272, t0) cancer_care_treatment_outcome CCTO:000273 Time to first flatus CCTO:000273 CCTO:000274 implies CCTO:000049 unknown_t CCTO:000274(time_t t0) = EVENT_STATE(CCTO:000274, t0) cancer_care_treatment_outcome CCTO:000274 Local skin reactions CCTO:000274 CCTO:000275 = time-to-first CCTO:000114 CCTO:000215 duration_t CCTO:000275(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000215) ) cancer_care_treatment_outcome CCTO:000275 Distant recurrence-free survival CCTO:000275 Toxicity that impairs or damages the heart. This condition is often caused by the administration of a pharmaceutical agent that initiates a poisonous or toxic response in cardiac tissue. event_t CCTO:000276(time_t t0) = EVENT_STATE(CCTO:000276, t0) NCIT:C27994 UMLS:C0876994 Cardiotoxicity Toxicity, cardiac cancer_care_treatment_outcome CCTO:000276 Cardiac toxicity CCTO:000276 Toxicity that impairs or damages the heart. This condition is often caused by the administration of a pharmaceutical agent that initiates a poisonous or toxic response in cardiac tissue. NCIT:C27994 Cardiotoxicity NCIT:C27994 Toxicity, cardiac NCIT:C27994 event_t CCTO:000277(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000277, t0, assessed_at) cancer_care_treatment_outcome CCTO:000277 Clinical tumor regression CCTO:000277 event_t CCTO:000278(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000278, t0, assessed_at) cancer_care_treatment_outcome Nodal response CCTO:000278 Lymph node response CCTO:000278 probability_t CCTO:000279(time_t t0, time_t assessed_at) = probability(CCTO:000278(t0, assessed_at) == TRUE, assessed_at) cancer_care_treatment_outcome Nodal response rate CCTO:000279 Lymph node response rate CCTO:000279 CCTO:000280 implies CCTO:000090 CCTO:000280 implies CCTO:000179 event_t CCTO:000280(time_t t0) = EVENT_STATE(CCTO:000280, t0) cancer_care_treatment_outcome CCTO:000280 Postoperative mortality CCTO:000280 event_t CCTO:000281(time_t t0) = EVENT_STATE(CCTO:000281, t0) cancer_care_treatment_outcome CCTO:000281 Sphincter preservation CCTO:000281 probability_t CCTO:000282(time_t t0) = probability(CCTO:000281, t0) cancer_care_treatment_outcome CCTO:000282 Sphincter preservation rate CCTO:000282 CCTO:000283 = time-to-first CCTO:000190 duration_t CCTO:000283(time_t t0) = time_to_first_event(CCTO:000190, t0) cancer_care_treatment_outcome CCTO:000283 Time to distant failure CCTO:000283 event_t CCTO:000284(time_t t0) = EVENT_STATE(CCTO:000284, t0) UMLS:C0205197 UMLS:C0580352 UMLS:C1554962 cancer_care_treatment_outcome Completion CCTO:000284 Treatment completion CCTO:000284 probability_t CCTO:000285(time_t t0) = probability(CCTO:000284, t0) cancer_care_treatment_outcome Completion rate CCTO:000285 Treatment completion rate CCTO:000285 event_t CCTO:000286(time_t t0) = EVENT_STATE(CCTO:000286, t0) cancer_care_treatment_outcome Analgesic use CCTO:000286 Analgesic consumption CCTO:000286 The flow of blood from a ruptured blood vessel. CCTO:000287 implies CCTO:000049 unknown_t CCTO:000287(time_t t0) = EVENT_STATE(CCTO:000287, t0) NCIT:C26791 UMLS:C0019080 Hemorrhage cancer_care_treatment_outcome Haemorrhage CCTO:000287 Bleeding CCTO:000287 The flow of blood from a ruptured blood vessel. NCIT:C26791 Hemorrhage NCIT:C26791 CCTO:000288 implies CCTO:000043 CCTO:000288 implies CCTO:000051 unknown_t CCTO:000288(time_t t0) = EVENT_STATE(CCTO:000288, t0) UMLS:C0517349 cancer_care_treatment_outcome CCTO:000288 Muscle strength CCTO:000288 probability_t CCTO:000289(time_t t0) = probability(CCTO:000159, t0) cancer_care_treatment_outcome CCTO:000289 Radiographic response rate CCTO:000289 CCTO:000290 implies NOT CCTO:000291 NOT CCTO:000290 implies CCTO:000291 event_t CCTO:000290(time_t t0) = NOT EVENT_STATE(CCTO:000291, t0) cancer_care_treatment_outcome CCTO:000290 Breast cancer-free CCTO:000290 A carcinoma arising from the breast, most commonly the terminal ductal-lobular unit. It is the most common malignant tumor in females. Risk factors include country of birth, family history, menstrual and reproductive history, fibrocystic disease and epithelial hyperplasia, exogenous estrogens, contraceptive agents, and ionizing radiation. The vast majority of breast carcinomas are adenocarcinomas (ductal or lobular). Breast carcinoma spreads by direct invasion, by the lymphatic route, and by the blood vessel route. The most common site of lymph node involvement is the axilla. CCTO:000291 implies CCTO:000070 CCTO:000291 implies NOT CCTO:000290 NOT CCTO:000291 implies CCTO:000290 event_t NULL NCIT:C4872 UMLS:C0006142 UMLS:C0678222 Breast cancer, NOS Breast carcinoma Cancer of Breast Cancer of the Breast Cancer, breast Carcinoma of Breast Carcinoma of the Breast Mammary carcinoma cancer_care_treatment_outcome CCTO:000291 Breast cancer CCTO:000291 A carcinoma arising from the breast, most commonly the terminal ductal-lobular unit. It is the most common malignant tumor in females. Risk factors include country of birth, family history, menstrual and reproductive history, fibrocystic disease and epithelial hyperplasia, exogenous estrogens, contraceptive agents, and ionizing radiation. The vast majority of breast carcinomas are adenocarcinomas (ductal or lobular). Breast carcinoma spreads by direct invasion, by the lymphatic route, and by the blood vessel route. The most common site of lymph node involvement is the axilla. NCIT:C4872 Breast cancer, NOS NCIT:C4872 Breast carcinoma NCIT:C4872 Cancer of Breast NCIT:C4872 Cancer of the Breast NCIT:C4872 Cancer, breast NCIT:C4872 Carcinoma of Breast NCIT:C4872 Carcinoma of the Breast NCIT:C4872 Mammary carcinoma NCIT:C4872 duration_t CCTO:000292(time_t t0) = time_to_first_event(CCTO:000291, t0) cancer_care_treatment_outcome CCTO:000292 Breast cancer-free interval CCTO:000292 CCTO:000293 = time-to-first CCTO:000215 duration_t CCTO:000293(time_t t0) = time_to_first_event(CCTO:000215, t0) cancer_care_treatment_outcome CCTO:000293 Time to distant recurrence CCTO:000293 duration_t CCTO:000294(time_t t0) = duration_of_event(CCTO:000321, t0) cancer_care_treatment_outcome CCTO:000294 Length of postoperative hospital stay CCTO:000294 CCTO:000295 implies NOT CCTO:000299 CCTO:000295 implies NOT CCTO:001107 event_t CCTO:000295(time_t t0) = EVENT_STATE(CCTO:000295, t0) cancer_care_treatment_outcome CCTO:000295 Biochemical control CCTO:000295 CCTO:000296 implies CCTO:000051 unknown_t CCTO:000296(time_t t0) = EVENT_STATE(CCTO:000296, t0) cancer_care_treatment_outcome CCTO:000296 Serum PSA CCTO:000296 The collection of PROMIS item scales that assess an individual's ability to carry out activities that require physical actions including more complex activities that require a combination of skills, often within a social context. event_t CCTO:000297(time_t t0) = EVENT_STATE(CCTO:000297, t0) NCIT:C122356 UMLS:C0516981 Physical Function Item Bank Physical function subordinate domain cancer_care_treatment_outcome CCTO:000297 Physical function CCTO:000297 The collection of PROMIS item scales that assess an individual's ability to carry out activities that require physical actions including more complex activities that require a combination of skills, often within a social context. NCIT:C122356 Physical Function Item Bank NCIT:C122356 Physical function subordinate domain NCIT:C122356 CCTO:000298 = time-to-first CCTO:000114 CCTO:000299 duration_t CCTO:000298(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000299) ) cancer_care_treatment_outcome CCTO:000298 Biochemical relapse-free survival CCTO:000298 CCTO:000299 implies CCTO:001107 CCTO:000299 implies NOT CCTO:000295 event_t NULL NCIT:C93229 UMLS:C2985506 PSA Failure PSA failure biochemical recurrence cancer_care_treatment_outcome CCTO:000299 Biochemical relapse CCTO:000299 PSA Failure NCIT:C93229 PSA failure NCIT:C93229 biochemical recurrence NCIT:C93229 duration_t CCTO:000300(time_t t0) = EVENT_STATE(CCTO:000300, t0) cancer_care_treatment_outcome CCTO:000300 PSA doubling time CCTO:000300 CCTO:000301 = time-to-first CCTO:000114 CCTO:001104 duration_t CCTO:000301(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:001104) ) cancer_care_treatment_outcome CCTO:000301 Regional recurrence free survival CCTO:000301 A performance status scale designed to assess disease progression and its affect on the daily living abilities of the patient. event_t CCTO:000302(time_t t0) = EVENT_STATE(CCTO:000302, t0) NCIT:C105721 UMLS:C1520224 UMLS:C3714786 ECOG Score Eastern Cooperative Oncology Group Performance Status cancer_care_treatment_outcome CCTO:000302 ECOG performance status CCTO:000302 A performance status scale designed to assess disease progression and its affect on the daily living abilities of the patient. NCIT:C105721 ECOG Score NCIT:C105721 Eastern Cooperative Oncology Group Performance Status NCIT:C105721 probability_t CCTO:000303(time_t t0) = probability(CCTO:000265, t0) cancer_care_treatment_outcome CCTO:000303 Biochemical response rate CCTO:000303 A measure of the health of a population that combines an assessment of both mortality and disability. (Taber's) unknown_t CCTO:000304(time_t t0) = EVENT_STATE(CCTO:000304, t0) NCIT:C21095 UMLS:C0080071 QALY cancer_care_treatment_outcome CCTO:000304 Quality adjusted life years CCTO:000304 A measure of the health of a population that combines an assessment of both mortality and disability. (Taber's) NCIT:C21095 QALY NCIT:C21095 An intense reaction (usually immunologic) developing at the site of injection OR A disorder characterized by an intense adverse reaction (usually immunologic) developing at the site of an injection. CCTO:000305 implies CCTO:000098 CCTO:000305 implies CCTO:001103 NCI:CTCAE:10022095 NCIT:C3508 UMLS:C0151735 Reaction, injection site cancer_care_treatment_outcome CCTO:000305 Injection site reaction CCTO:000305 An intense reaction (usually immunologic) developing at the site of injection OR A disorder characterized by an intense adverse reaction (usually immunologic) developing at the site of an injection. NCI:CTCAE NCIT:C3508 Reaction, injection site NCIT:C3508 CCTO:000306 implies CCTO:000118 event_t CCTO:000306(time_t t0) = EVENT_STATE(CCTO:000306, t0) cancer_care_treatment_outcome CCTO:000306 Subject Satisfaction Score CCTO:000306 A 9-item questionnaire, developed by Cleeland and Mendoza, designed to assess the severity of fatigue and the impact of fatigue on daily functioning in cancer patients. CCTO:000307 implies CCTO:000043 CCTO:000307 implies CCTO:000118 event_t CCTO:000307(time_t t0) = EVENT_STATE(CCTO:000307, t0) NCIT:C74297 UMLS:C2698562 BFI cancer_care_treatment_outcome CCTO:000307 Brief Fatigue Inventory CCTO:000307 A 9-item questionnaire, developed by Cleeland and Mendoza, designed to assess the severity of fatigue and the impact of fatigue on daily functioning in cancer patients. NCIT:C74297 BFI NCIT:C74297 CCTO:000308 implies CCTO:000049 event_t CCTO:000308(time_t t0) = EVENT_STATE(CCTO:000308, t0) cancer_care_treatment_outcome CCTO:000308 Sexuality problems CCTO:000308 CCTO:000309 implies CCTO:000049 CCTO:000309 implies CCTO:000150 event_t CCTO:000309(time_t t0) = EVENT_STATE(CCTO:000309, t0) cancer_care_treatment_outcome CCTO:000309 Readmission CCTO:000309 probability_t CCTO:000310(time_t t0) = probability(CCTO:000309, t0) cancer_care_treatment_outcome CCTO:000310 Readmission rate CCTO:000310 CCTO:000311 implies CCTO:000049 event_t CCTO:000311(time_t t0) = EVENT_STATE(CCTO:000311, t0) cancer_care_treatment_outcome CCTO:000311 Intimacy problems CCTO:000311 probability_t CCTO:000312(time_t t0) = probability(CCTO:000044, t0) cancer_care_treatment_outcome CCTO:000312 Adherence rate CCTO:000312 CCTO:000313 implies CCTO:000049 event_t CCTO:000313(time_t t0) = EVENT_STATE(CCTO:000313, t0) cancer_care_treatment_outcome CCTO:000313 Erectile function CCTO:000313 probability_t CCTO:000314(time_t t0) = probability(CCTO:000049, t0) cancer_care_treatment_outcome Adverse events rate CCTO:000314 Adverse event rate CCTO:000314 CCTO:000315 = time-to-first CCTO:000114 CCTO:000270 duration_t CCTO:000315(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:000270) ) cancer_care_treatment_outcome CCTO:000315 SSE-FS Symptomatic skeletal event free survival CCTO:000315 duration_t CCTO:000316(time_t t0) = min( time_to_first_event(t0, CCTO:000114), time_to_first_event(t0, CCTO:001107) ) cancer_care_treatment_outcome CCTO:000316 Biochemical disease-free survival CCTO:000316 event_t CCTO:000317(time_t t0) = EVENT_STATE(CCTO:000317, t0) cancer_care_treatment_outcome CCTO:000317 Local failure CCTO:000317 probability_t CCTO:000318(time_t t0) = probability(CCTO:000317, t0) cancer_care_treatment_outcome CCTO:000318 Local failure rate CCTO:000318 A group of neurologic disorders caused by damage to the nervous system following exposure to pharmacologic, biologic, and chemical agents. Examples of neurotoxins include chemotherapy agents, radiation treatment, heavy metals, pesticides, and food additives. event_t CCTO:000319(time_t t0) = EVENT_STATE(CCTO:000319, t0) NCIT:C27961 UMLS:C0235032 Neurotoxicity syndrome cancer_care_treatment_outcome CCTO:000319 Neurotoxicity CCTO:000319 A group of neurologic disorders caused by damage to the nervous system following exposure to pharmacologic, biologic, and chemical agents. Examples of neurotoxins include chemotherapy agents, radiation treatment, heavy metals, pesticides, and food additives. NCIT:C27961 Neurotoxicity syndrome NCIT:C27961 CCTO:000320 implies CCTO:000049 CCTO:000320 implies CCTO:000129 event_t CCTO:000320(time_t t0) = EVENT_STATE(CCTO:000320, t0) cancer_care_treatment_outcome CCTO:000320 Infectious complications CCTO:000320 unknown_t CCTO:000321(time_t t0) = EVENT_STATE(CCTO:000321, t0) cancer_care_treatment_outcome CCTO:000321 Postoperative hospital stay CCTO:000321 An infection that occurs at a surgical site within 30 days after an operation. CCTO:000322 implies CCTO:000098 unknown_t CCTO:000322(time_t t0) = EVENT_STATE(CCTO:000322, t0) NCIT:C112019 UMLS:C2316459 cancer_care_treatment_outcome CCTO:000322 Surgical site infection CCTO:000322 An infection that occurs at a surgical site within 30 days after an operation. NCIT:C112019 duration_t CCTO:000323(time_t t0) = time_to_first_event(CCTO:000317, t0) cancer_care_treatment_outcome CCTO:000323 Time to local failure CCTO:000323 Expelling the contents of the stomach and the sensations associated with it. They are symptoms of an underlying disease or condition and not a specific illness. CCTO:000324 implies CCTO:000049 CCTO:000324 is-union-of CCTO:000333 CCTO:000554 CCTO:000333 implies CCTO:000324 CCTO:000554 implies CCTO:000324 unknown_t CCTO:000324(time_t t0) = EVENT_STATE(CCTO:000324, t0) NCIT:C3259 UMLS:C0027498 Vomiting and Nausea cancer_care_treatment_outcome CCTO:000324 Nausea and vomiting CCTO:000324 Expelling the contents of the stomach and the sensations associated with it. They are symptoms of an underlying disease or condition and not a specific illness. NCIT:C3259 Vomiting and Nausea NCIT:C3259 CCTO:000325 implies CCTO:000049 CCTO:000325 implies CCTO:000137 event_t CCTO:000325(time_t t0) = EVENT_STATE(CCTO:000325, t0) cancer_care_treatment_outcome CCTO:000325 Late complications CCTO:000325 probability_t CCTO:000326(time_t t0) = probability(CCTO:000129, t0) cancer_care_treatment_outcome CCTO:000326 Infection rate CCTO:000326 CCTO:000327 implies CCTO:000064 event_t CCTO:000327(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000327, t0, assessed_at) cancer_care_treatment_outcome CCTO:000327 CNS progression CCTO:000327 CCTO:000328 = time-to-first CCTO:000327 duration_t CCTO:000328(time_t t0) = time_to_first_event(CCTO:000327, t0) cancer_care_treatment_outcome CCTO:000328 Time to CNS progression CCTO:000328 CCTO:000329 = time-to-first CCTO:000120 duration_t CCTO:000329(time_t t0) = time_to_first_event(CCTO:000120, t0) cancer_care_treatment_outcome CCTO:000329 Time to PSA response CCTO:000329 event_t CCTO:000330(time_t t0) = CCTO:000114(t0) AND ASSOCIATED(CCTO:000114, CCTO:000081) cancer_care_treatment_outcome CCTO:000330 Relapse related mortality CCTO:000330 event_t CCTO:000331(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000331, t0, assessed_at) cancer_care_treatment_outcome CCTO:000331 Bone marrow response CCTO:000331 CCTO:000332 implies CCTO:000049 unknown_t CCTO:000332(time_t t0) = EVENT_STATE(CCTO:000332, t0) cancer_care_treatment_outcome CCTO:000332 Stent patency CCTO:000332 A disorder characterized by a queasy sensation and/or the urge to vomit OR A question about whether an individual is or was bothered by nausea OR A question about the usual severity of an individual's nausea OR A question about whether a person has or had nausea OR A question about how often an individual has or had nausea OR A question about how much nausea an individual experienced during the specified time period OR A question about an individual's distress from their nausea OR Upper abdominal discomfort associated with an urge to vomit. CCTO:000333 implies CCTO:000049 CCTO:000333 implies CCTO:001108 NCI:CTCAE:10028813 NCIT:C107520 NCIT:C125272 NCIT:C125304 NCIT:C125336 NCIT:C125646 NCIT:C3258 NCIT:C57839 NCIT:C91124 UMLS:C0027497 UMLS:C1963179 UMLS:C2984057 UMLS:C3829611 Bothered by Nausea Frequency of Nausea Had nausea Have nausea Have you felt nauseated How much distress nausea How much nausea did you have during this period How much nausea during this period How often nausea I have nausea Nausea adverse event Nausea frequency Usual severity nausea cancer_care_treatment_outcome CCTO:000333 Nausea CCTO:000333 A disorder characterized by a queasy sensation and/or the urge to vomit OR A question about whether an individual is or was bothered by nausea OR A question about the usual severity of an individual's nausea OR A question about whether a person has or had nausea OR A question about how often an individual has or had nausea OR A question about how much nausea an individual experienced during the specified time period OR A question about an individual's distress from their nausea OR Upper abdominal discomfort associated with an urge to vomit. NCI:CTCAE NCIT:C107520 NCIT:C125272 NCIT:C125304 NCIT:C125336 NCIT:C125646 NCIT:C3258 NCIT:C91124 Bothered by Nausea NCIT:C125646 Frequency of Nausea NCIT:C125272 Had nausea NCIT:C91124 Have nausea NCIT:C91124 Have you felt nauseated NCIT:C91124 How much distress nausea NCIT:C125336 How much nausea did you have during this period NCIT:C107520 How much nausea during this period NCIT:C107520 How often nausea NCIT:C125272 I have nausea NCIT:C91124 Nausea adverse event NCIT:C57839 Nausea frequency NCIT:C107520 Nausea frequency NCIT:C125272 Usual severity nausea NCIT:C125304 Painful sensation in the bones OR A disorder characterized by marked discomfort sensation in the bones. CCTO:000334 implies CCTO:000107 CCTO:000334 implies CCTO:001109 NCI:CTCAE:10006002 NCIT:C38644 UMLS:C0151825 Bone pain (diffuse not joint pain or arthritis) cancer_care_treatment_outcome CCTO:000334 Bone pain CCTO:000334 Painful sensation in the bones OR A disorder characterized by marked discomfort sensation in the bones. NCI:CTCAE NCIT:C38644 Bone pain (diffuse not joint pain or arthritis) NCIT:C38644 duration_t CCTO:000335(time_t t0) = time_to_first_event(CCTO:000112, t0) cancer_care_treatment_outcome CCTO:000335 Time to radiographic progression CCTO:000335 CCTO:000336 implies CCTO:000064 event_t CCTO:000336(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000336, t0, assessed_at) cancer_care_treatment_outcome CCTO:000336 Untreatable progression CCTO:000336 CCTO:000337 = time-to-first CCTO:000336 duration_t CCTO:000337(time_t t0) = time_to_first_event(CCTO:000336, t0) cancer_care_treatment_outcome CCTO:000337 Time to untreatable progression CCTO:000337 duration_t CCTO:000338(time_t t0) = EVENT_STATE(CCTO:001110, t0) ? CCTO:000062(t0) : NULL cancer_care_treatment_outcome CCTO:000338 Breast cancer specific survival CCTO:000338 duration_t CCTO:000339(time_t t0) = time_to_first_event(CCTO:000166, t0) cancer_care_treatment_outcome CCTO:000339 Time to skeletal-related event CCTO:000339 CCTO:000340 implies CCTO:000043 CCTO:000340 implies NOT CCTO:000130 event_t CCTO:000340(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000340, t0, assessed_at) UMLS:C0002766 UMLS:C1304888 cancer_care_treatment_outcome CCTO:000340 Pain control CCTO:000340 CCTO:000341 implies CCTO:001112 CCTO:000341 implies NOT CCTO:000256 event_t CCTO:000341(time_t t0) = EVENT_STATE(CCTO:000341, t0) cancer_care_treatment_outcome Haematologic toxicity Haematological toxicity Hematological toxicity Hematotoxicity CCTO:000341 Hematologic toxicity CCTO:000341 CCTO:000342 implies NOT CCTO:001111 NOT CCTO:000342 implies CCTO:001111 event_t CCTO:000342(time_t t0, time_t assessed_at) = NOT CCTO:001111(t0, assessed_at) cancer_care_treatment_outcome Biological progression free CCTO:000342 Biological progression-free CCTO:000342 CCTO:000343 = time-to-first CCTO:001111 duration_t CCTO:000343(time_t t0) = time_to_first_event(CCTO:001111, t0) cancer_care_treatment_outcome Biological progression free interval CCTO:000343 Biological progression-free interval CCTO:000343 CCTO:000344 implies CCTO:000065 event_t CCTO:000344(time_t t0, time_t assessed_at) = EVENT_COMPARISON(CCTO:000344, t0, assessed_at) cancer_care_treatment_outcome Immune-related disease response CCTO:000344 Immune-related objective response CCTO:000344 probability_t CCTO:000345(time_t t0) = probability(CCTO:000344, t0) cancer_care_treatment_outcome CCTO:000345 Immune-related objective response rate CCTO:000345 duration_t CCTO:000346(time_t t0) = EVENT_STATE(CCTO:000346, t0) cancer_care_treatment_outcome CCTO:000346 Long term survival CCTO:000346 A standard terminology developed to report adverse events occurring in cancer clinical trials. Common terminology criteria for adverse events (CTCAE) are used in study adverse event summaries and Investigational New Drug reports to the Food and Drug Administration. The CTCAE contain a grading scale for each adverse event term representing the severity of the event OR A standard terminology developed to report adverse events occurring in cancer clinical trials. Common toxicity criteria (CTC) is used in study adverse event summaries and Investigational New Drug reports to the Food and Drug Administration. The CTC contains a grading scale for each adverse event term representing the severity of the event. (NCI) event_t NULL NCIT:C25468 NCIT:C49704 UMLS:C1516728 CTCAE CTCAE Grades Common Terminology Criteria for Adverse Events Common Toxicity Criteria Common Toxicity Criteria for Adverse Events Standard toxicity grade cancer_care_treatment_outcome CTCAE v3.0 CTCAE v4.0 CTCAE v4.03 NCI CTCAE NCI CTCAE v3.0 NCI CTCAE version 3.0 NCI CTCAE version 4.0 CCTO:000347 National Cancer Institute Common Terminology Criteria for Adverse Events CCTO:000347 A standard terminology developed to report adverse events occurring in cancer clinical trials. Common terminology criteria for adverse events (CTCAE) are used in study adverse event summaries and Investigational New Drug reports to the Food and Drug Administration. The CTCAE contain a grading scale for each adverse event term representing the severity of the event OR A standard terminology developed to report adverse events occurring in cancer clinical trials. Common toxicity criteria (CTC) is used in study adverse event summaries and Investigational New Drug reports to the Food and Drug Administration. The CTC contains a grading scale for each adverse event term representing the severity of the event. (NCI) NCIT:C25468 NCIT:C49704 CTCAE NCIT:C25468 CTCAE NCIT:C49704 CTCAE Grades NCIT:C49704 Common Terminology Criteria for Adverse Events NCIT:C25468 Common Terminology Criteria for Adverse Events NCIT:C49704 Common Toxicity Criteria NCIT:C25468 Common Toxicity Criteria NCIT:C49704 Common Toxicity Criteria for Adverse Events NCIT:C49704 Standard toxicity grade NCIT:C49704 CCTO:000348 implies CCTO:000118 event_t NULL cancer_care_treatment_outcome EORTC QLQ-C30 health-related quality of life on the 4- and 7-point EORTC QLQ-C30 the EORTC QLQ-C30 Dyspnea the EORTC QLQ-C30 Global Health Status-/Quality of Life Domain the EORTC QLQ-C30 Physical Functioning Domain CCTO:000348 EORTC QLQ-C30 questionnaire CCTO:000348 Standard parameters to be used when documenting response of solid tumors to treatment; a set of published rules that define when cancer patients improve (''respond''), stay the same (''stable''), or worsen (''progression'') during treatments. (from www.recist.com) unknown_t NULL NCIT:C49164 UMLS:C1709926 RECIST cancer_care_treatment_outcome RECIST criteria CCTO:000349 Response Evaluation Criteria in Solid Tumors CCTO:000349 Standard parameters to be used when documenting response of solid tumors to treatment; a set of published rules that define when cancer patients improve (''respond''), stay the same (''stable''), or worsen (''progression'') during treatments. (from www.recist.com) NCIT:C49164 RECIST NCIT:C49164 A diagnostic or treatment procedure performed by manual and/or instrumental means, often involving an incision and the removal or replacement of a diseased organ or tissue; of or relating to or involving or used in surgery or requiring or amenable to treatment by surgery OR The branch of medical science that treats disease or injury by operative procedures. NCIT:C15329 NCIT:C17173 UMLS:C0038894 UMLS:C0038895 UMLS:C0543467 UMLS:C1552276 Operation Surgery Surgical Surgical interventions Surgical procedure Surgical procedures Surgically cancer_care_treatment_outcome CCTO:000350 Surgery-related concept CCTO:000350 A diagnostic or treatment procedure performed by manual and/or instrumental means, often involving an incision and the removal or replacement of a diseased organ or tissue; of or relating to or involving or used in surgery or requiring or amenable to treatment by surgery OR The branch of medical science that treats disease or injury by operative procedures. NCIT:C15329 NCIT:C17173 Operation NCIT:C15329 Surgery NCIT:C15329 Surgery NCIT:C17173 Surgical NCIT:C15329 Surgical interventions NCIT:C15329 Surgical procedure NCIT:C15329 Surgical procedures NCIT:C15329 Surgically NCIT:C15329 cancer_care_treatment_outcome CCTO:000351 Disease clearance CCTO:000351 cancer_care_treatment_outcome CCTO:000352 Subjective assessment CCTO:000352 A medical specialty concerned with the skin, its structure, functions, diseases, and treatment. (MeSH) NCIT:C16500 UMLS:C0011627 UMLS:C0259831 Dermatology cancer_care_treatment_outcome CCTO:000353 Dermatologic concept CCTO:000353 A medical specialty concerned with the skin, its structure, functions, diseases, and treatment. (MeSH) NCIT:C16500 Dermatology NCIT:C16500 A disorder characterized by an reduction in the amount of hemoglobin in 100 ml of blood. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability OR A reduction in the number of red blood cells, the amount of hemoglobin, and/or the volume of packed red blood cells. Clinically, anemia represents a reduction in the oxygen-transporting capacity of a designated volume of blood, resulting from an imbalance between blood loss (through hemorrhage or hemolysis) and blood production. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability. CCTO:000354 implies CCTO:000049 CCTO:000354 implies CCTO:001112 CCTO:000354(time_t t0) = EVENT_STATE(CCTO:000354, t0) NCI:CTCAE:10002272 NCIT:C2869 UMLS:C0002871 UMLS:C1000483 cancer_care_treatment_outcome CCTO:000354 Anemia CCTO:000354 A disorder characterized by an reduction in the amount of hemoglobin in 100 ml of blood. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability OR A reduction in the number of red blood cells, the amount of hemoglobin, and/or the volume of packed red blood cells. Clinically, anemia represents a reduction in the oxygen-transporting capacity of a designated volume of blood, resulting from an imbalance between blood loss (through hemorrhage or hemolysis) and blood production. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability. NCI:CTCAE NCIT:C2869 A laboratory finding indicating decreased number of hematopoietic cells in the bone marrow. It may result from decreased proliferation of all or part of the hematopoietic series (erythroid, myeloid, and megakaryocytic). Microscopically, the hematopoietic cells are replaced by adipocytes OR A disorder characterized by the inability of the bone marrow to produce hematopoietic elements. CCTO:000355 implies CCTO:000049 CCTO:000355 implies CCTO:001112 CCTO:000355(time_t t0) = EVENT_STATE(CCTO:000355, t0) NCI:CTCAE:10048580 NCIT:C35167 UMLS:C0151773 Bone marrow hypoplasia Hypocellular bone marrow cancer_care_treatment_outcome CCTO:000355 Bone marrow hypocellular CCTO:000355 A laboratory finding indicating decreased number of hematopoietic cells in the bone marrow. It may result from decreased proliferation of all or part of the hematopoietic series (erythroid, myeloid, and megakaryocytic). Microscopically, the hematopoietic cells are replaced by adipocytes OR A disorder characterized by the inability of the bone marrow to produce hematopoietic elements. NCI:CTCAE NCIT:C35167 Bone marrow hypoplasia NCIT:C35167 Hypocellular bone marrow NCIT:C35167 A disorder characterized by systemic pathological activation of blood clotting mechanisms which results in clot formation throughout the body. There is an increase in the risk of hemorrhage as the body is depleted of platelets and coagulation factors OR A pathological process where the blood starts to coagulate throughout the whole body. This depletes the body of its platelets and coagulation factors, and there is an increased risk of hemorrhage. CCTO:000356 implies CCTO:000049 CCTO:000356 implies CCTO:001112 CCTO:000356(time_t t0) = EVENT_STATE(CCTO:000356, t0) NCI:CTCAE:10013442 NCIT:C2992 UMLS:C0012739 UMLS:C0333710 Coagulation (DIC), Disseminated Intravascular Consumptive coagulopathy DIC DIC, Disseminated Intravascular Coagulation Disseminated Intravascular Coagulation (DIC) Intravascular Coagulation (DIC), Disseminated cancer_care_treatment_outcome CCTO:000356 Disseminated intravascular coagulation CCTO:000356 A disorder characterized by systemic pathological activation of blood clotting mechanisms which results in clot formation throughout the body. There is an increase in the risk of hemorrhage as the body is depleted of platelets and coagulation factors OR A pathological process where the blood starts to coagulate throughout the whole body. This depletes the body of its platelets and coagulation factors, and there is an increased risk of hemorrhage. NCI:CTCAE NCIT:C2992 Coagulation (DIC), Disseminated Intravascular NCIT:C2992 Consumptive coagulopathy NCIT:C2992 DIC NCIT:C2992 DIC, Disseminated Intravascular Coagulation NCIT:C2992 Disseminated Intravascular Coagulation (DIC) NCIT:C2992 Intravascular Coagulation (DIC), Disseminated NCIT:C2992 Neutropenia associated with fever, the latter indicating the presence of an infection OR A disorder characterized by an ANC <1000/mm3 and a single temperature of >38.3 degrees C (101 degrees F) or a sustained temperature of >=38 degrees C (100.4 degrees F) for more than one hour CCTO:000357 implies CCTO:000049 CCTO:000357 implies CCTO:001112 CCTO:000357(time_t t0) = EVENT_STATE(CCTO:000357, t0) NCI:CTCAE:10016288 NCIT:C35665 UMLS:C0746883 cancer_care_treatment_outcome CCTO:000357 Febrile neutropenia CCTO:000357 Neutropenia associated with fever, the latter indicating the presence of an infection OR A disorder characterized by an ANC <1000/mm3 and a single temperature of >38.3 degrees C (101 degrees F) or a sustained temperature of >=38 degrees C (100.4 degrees F) for more than one hour NCI:CTCAE NCIT:C35665 A disorder characterized by laboratory test results that indicate widespread erythrocyte cell membrane destruction OR Disruption of the integrity of the erythrocyte membrane causing release of hemoglobin OR The determination of the amount of destruction of red blood cells present in a sample. CCTO:000358 implies CCTO:000049 CCTO:000358 implies CCTO:001112 CCTO:000358(time_t t0) = EVENT_STATE(CCTO:000358, t0) NCI:CTCAE:10019491 NCIT:C111208 NCIT:C37965 UMLS:C0312853 UMLS:C2937287 UMLS:C2945560 UMLS:C3814778 HEMOLYSI Hemolytic Hemolytic Index cancer_care_treatment_outcome CCTO:000358 Hemolysis CCTO:000358 A disorder characterized by laboratory test results that indicate widespread erythrocyte cell membrane destruction OR Disruption of the integrity of the erythrocyte membrane causing release of hemoglobin OR The determination of the amount of destruction of red blood cells present in a sample. NCI:CTCAE NCIT:C111208 NCIT:C37965 HEMOLYSI NCIT:C111208 Hemolytic NCIT:C37965 Hemolytic Index NCIT:C111208 A disorder characterized by a form of thrombotic microangiopathy with renal failure, hemolytic anemia, and severe thrombocytopenia OR Acute kidney injury associated with microangiopathic hemolytic anemia and thrombocytopenia. CCTO:000359 implies CCTO:000049 CCTO:000359 implies CCTO:001112 CCTO:000359(time_t t0) = EVENT_STATE(CCTO:000359, t0) NCI:CTCAE:10019515 NCIT:C75545 UMLS:C0019061 Hemolytic-uremic syndrome cancer_care_treatment_outcome CCTO:000359 Hemolytic uremic syndrome CCTO:000359 A disorder characterized by a form of thrombotic microangiopathy with renal failure, hemolytic anemia, and severe thrombocytopenia OR Acute kidney injury associated with microangiopathic hemolytic anemia and thrombocytopenia. NCI:CTCAE NCIT:C75545 Hemolytic-uremic syndrome NCIT:C75545 A disorder characterized by laboratory test results that indicate an increased number of white blood cells in the blood OR A laboratory test result indicating an increased number of white blood cells in the peripheral blood. CCTO:000360 implies CCTO:000049 CCTO:000360 implies CCTO:001112 CCTO:000360(time_t t0) = EVENT_STATE(CCTO:000360, t0) NCI:CTCAE:10024378 NCIT:C35524 UMLS:C0023518 UMLS:C0750426 WBC Increased White blood cell count increased cancer_care_treatment_outcome CCTO:000360 Leukocytosis CCTO:000360 A disorder characterized by laboratory test results that indicate an increased number of white blood cells in the blood OR A laboratory test result indicating an increased number of white blood cells in the peripheral blood. NCI:CTCAE NCIT:C35524 WBC Increased NCIT:C35524 White blood cell count increased NCIT:C35524 A painful sensation in a lymph node OR A disorder characterized by a sensation of marked discomfort in a lymph node. CCTO:000361 implies CCTO:000107 CCTO:000361 implies CCTO:001112 CCTO:000361(time_t t0) = EVENT_STATE(CCTO:000361, t0) NCI:CTCAE:10025182 NCIT:C56120 NCIT:C78440 UMLS:C0578050 UMLS:C1963194 Lymph node pain adverse event cancer_care_treatment_outcome CCTO:000361 Lymph node pain CCTO:000361 A painful sensation in a lymph node OR A disorder characterized by a sensation of marked discomfort in a lymph node. NCI:CTCAE NCIT:C78440 Lymph node pain adverse event NCIT:C56120 A non-neoplastic or neoplastic disorder affecting the spleen. Examples include infection, hemangioma, lymphoma, leukemia and angiosarcoma OR A disorder of the spleen. CCTO:000362 implies CCTO:000049 CCTO:000362 implies CCTO:001112 CCTO:000362(time_t t0) = EVENT_STATE(CCTO:000362, t0) NCI:CTCAE:10041633 NCIT:C35823 UMLS:C0037997 Splenic disorder cancer_care_treatment_outcome CCTO:000362 Spleen disorder CCTO:000362 A non-neoplastic or neoplastic disorder affecting the spleen. Examples include infection, hemangioma, lymphoma, leukemia and angiosarcoma OR A disorder of the spleen. NCI:CTCAE NCIT:C35823 Splenic disorder NCIT:C35823 A coagulation disorder characterized by extensive formation of thrombi in small blood vessels throughout the body due to low levels of ADAMTS13 protein, and resulting in consumption of circulating platelets, which is characterized by thrombocytopenia, anemia, neurologic changes, and sometimes fever and renal dysfunction OR A disorder characterized by the presence of microangiopathic hemolytic anemia, thrombocytopenic purpura, fever, renal abnormalities and neurological abnormalities such as seizures, hemiplegia, and visual disturbances. It is an acute or subacute condition. CCTO:000363 implies CCTO:000049 CCTO:000363 implies CCTO:001112 CCTO:000363(time_t t0) = EVENT_STATE(CCTO:000363, t0) NCI:CTCAE:10043648 NCIT:C78797 UMLS:C0034155 Moschowitz disease cancer_care_treatment_outcome CCTO:000363 Thrombotic thrombocytopenic purpura CCTO:000363 A coagulation disorder characterized by extensive formation of thrombi in small blood vessels throughout the body due to low levels of ADAMTS13 protein, and resulting in consumption of circulating platelets, which is characterized by thrombocytopenia, anemia, neurologic changes, and sometimes fever and renal dysfunction OR A disorder characterized by the presence of microangiopathic hemolytic anemia, thrombocytopenic purpura, fever, renal abnormalities and neurological abnormalities such as seizures, hemiplegia, and visual disturbances. It is an acute or subacute condition. NCI:CTCAE NCIT:C78797 Moschowitz disease NCIT:C78797 Signs and symptoms related to acute ischemia of the myocardium secondary to coronary artery disease. The clinical presentation covers a spectrum of heart diseases from unstable angina to myocardial infarction OR A disorder characterized by signs and symptoms related to acute ischemia of the myocardium secondary to coronary artery disease. The clinical presentation covers a spectrum of heart diseases from unstable angina to myocardial infarction. CCTO:000364 implies CCTO:000049 CCTO:000364 implies CCTO:001113 CCTO:000364(time_t t0) = EVENT_STATE(CCTO:000364, t0) NCI:CTCAE:10051592 NCIT:C53652 UMLS:C0948089 cancer_care_treatment_outcome CCTO:000364 Acute coronary syndrome CCTO:000364 Signs and symptoms related to acute ischemia of the myocardium secondary to coronary artery disease. The clinical presentation covers a spectrum of heart diseases from unstable angina to myocardial infarction OR A disorder characterized by signs and symptoms related to acute ischemia of the myocardium secondary to coronary artery disease. The clinical presentation covers a spectrum of heart diseases from unstable angina to myocardial infarction. NCI:CTCAE NCIT:C53652 A heart disorder characterized by a defect in aortic valve structure or function OR A disorder characterized by a defect in aortic valve function or structure. CCTO:000365 implies CCTO:000049 CCTO:000365 implies CCTO:001113 CCTO:000365(time_t t0) = EVENT_STATE(CCTO:000365, t0) NCI:CTCAE:10061589 NCIT:C78650 UMLS:C1260873 Aortic valve disorder cancer_care_treatment_outcome CCTO:000365 Aortic valve disease CCTO:000365 A heart disorder characterized by a defect in aortic valve structure or function OR A disorder characterized by a defect in aortic valve function or structure. NCI:CTCAE NCIT:C78650 Aortic valve disorder NCIT:C78650 A disorder characterized by a dysrhythmia without cardiac electrical activity. Typically, this is accompanied by cessation of the pumping function of the heart OR An electrocardiographic finding showing no cardiac electrical activity on the monitor or printed strip for the entire duration of the recording. (CDISC) OR The sudden cessation of cardiac activity in an individual who becomes unresponsive, without normal breathing and no signs of circulation. Cardiac arrest may be reversed by CPR, and/or defibrillation, cardioversion or cardiac pacing. CCTO:000366 implies CCTO:000049 CCTO:000366 implies CCTO:001113 CCTO:000366(time_t t0) = EVENT_STATE(CCTO:000366, t0) NCI:CTCAE:10003586 NCI:CTCAE:10007515 NCIT:C116130 NCIT:C50479 NCIT:C54766 UMLS:C0018790 UMLS:C1963122 Arrest, cardiac Asystole adverse event Asystole by ECG Finding Cardiac arrest Heart arrest cancer_care_treatment_outcome CCTO:000366 Asystole CCTO:000366 A disorder characterized by a dysrhythmia without cardiac electrical activity. Typically, this is accompanied by cessation of the pumping function of the heart OR An electrocardiographic finding showing no cardiac electrical activity on the monitor or printed strip for the entire duration of the recording. (CDISC) OR The sudden cessation of cardiac activity in an individual who becomes unresponsive, without normal breathing and no signs of circulation. Cardiac arrest may be reversed by CPR, and/or defibrillation, cardioversion or cardiac pacing. NCI:CTCAE NCIT:C116130 NCIT:C50479 Arrest, cardiac NCIT:C50479 Asystole adverse event NCIT:C54766 Asystole by ECG Finding NCIT:C116130 Cardiac arrest NCIT:C50479 Heart arrest NCIT:C50479 A disorder characterized by a dysrhythmia without discernible P waves and an irregular ventricular response due to multiple reentry circuits. The rhythm disturbance originates above the ventricles OR An electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregularly irregular ventricular response. (CDISC) OR A disorder characterized by an electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregular ventricular response. (CDISC) CCTO:000367 implies CCTO:000049 CCTO:000367 implies CCTO:001113 CCTO:000367(time_t t0) = EVENT_STATE(CCTO:000367, t0) NCI:CTCAE:10003658 NCIT:C111092 NCIT:C50466 NCIT:C54767 UMLS:C0004238 UMLS:C0344434 UMLS:C1963067 AF AFib Atrial Fibrillation by ECG Finding Atrial Fibrillation by EKG Finding Atrial fibrillation adverse event cancer_care_treatment_outcome CCTO:000367 Atrial fibrillation CCTO:000367 A disorder characterized by a dysrhythmia without discernible P waves and an irregular ventricular response due to multiple reentry circuits. The rhythm disturbance originates above the ventricles OR An electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregularly irregular ventricular response. (CDISC) OR A disorder characterized by an electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregular ventricular response. (CDISC) NCI:CTCAE NCIT:C111092 NCIT:C50466 AF NCIT:C111092 AF NCIT:C50466 AFib NCIT:C111092 AFib NCIT:C50466 Atrial Fibrillation by ECG Finding NCIT:C111092 Atrial Fibrillation by EKG Finding NCIT:C111092 Atrial fibrillation adverse event NCIT:C54767 A disorder characterized by an electrocardiographic finding of an organized, regular atrial rhythm with atrial rate of 240-340 beats per minute. Multiple P waves typically appear in the inferior leads in a saw tooth-like pattern between the QRS complexes. (CDISC) OR An electrocardiographic finding of an organized, regular atrial rhythm with atrial rate of 240-340 beats per minute. Multiple P waves typically appear in the inferior leads in a saw tooth like pattern between the QRS complexes. (CDISC) OR A disorder characterized by a dysrhythmia with organized rhythmic atrial contractions with a rate of 200-300 beats per minute. The rhythm disturbance originates in the atria. CCTO:000368 implies CCTO:000049 CCTO:000368 implies CCTO:001113 CCTO:000368(time_t t0) = EVENT_STATE(CCTO:000368, t0) NCI:CTCAE:10003662 NCIT:C111094 NCIT:C51224 NCIT:C54768 UMLS:C0004239 UMLS:C0344423 UMLS:C1963068 Atrial Flutter by ECG Finding Atrial Flutter by EKG Finding Atrial flutter adverse event cancer_care_treatment_outcome CCTO:000368 Atrial flutter CCTO:000368 A disorder characterized by an electrocardiographic finding of an organized, regular atrial rhythm with atrial rate of 240-340 beats per minute. Multiple P waves typically appear in the inferior leads in a saw tooth-like pattern between the QRS complexes. (CDISC) OR An electrocardiographic finding of an organized, regular atrial rhythm with atrial rate of 240-340 beats per minute. Multiple P waves typically appear in the inferior leads in a saw tooth like pattern between the QRS complexes. (CDISC) OR A disorder characterized by a dysrhythmia with organized rhythmic atrial contractions with a rate of 200-300 beats per minute. The rhythm disturbance originates in the atria. NCI:CTCAE NCIT:C111094 NCIT:C51224 Atrial Flutter by ECG Finding NCIT:C111094 Atrial Flutter by EKG Finding NCIT:C111094 Atrial flutter adverse event NCIT:C54768 A disorder characterized by a dysrhythmia with complete failure of atrial electrical impulse conduction through the AV node to the ventricles OR A disorder characterized by an electrocardiographic finding of complete failure of atrial electrical impulse conduction to the ventricles. This is manifested on the ECG by disassociation of atrial and ventricular rhythms. The atrial rate must be faster than the ventricular rate. (CDISC) CCTO:000369 implies CCTO:000049 CCTO:000369 implies CCTO:001113 CCTO:000369(time_t t0) = EVENT_STATE(CCTO:000369, t0) NCI:CTCAE:10003673 NCIT:C50501 UMLS:C0151517 UMLS:C2215935 AV Block Third Degree Atrioventricular block, third degree Complete AV Block Complete atrioventricular block Complete heart block Non-congenital complete atrioventricular block Third Degree AV Block Third degree atrioventricular block cancer_care_treatment_outcome CCTO:000369 Atrioventricular block complete CCTO:000369 A disorder characterized by a dysrhythmia with complete failure of atrial electrical impulse conduction through the AV node to the ventricles OR A disorder characterized by an electrocardiographic finding of complete failure of atrial electrical impulse conduction to the ventricles. This is manifested on the ECG by disassociation of atrial and ventricular rhythms. The atrial rate must be faster than the ventricular rate. (CDISC) NCI:CTCAE NCIT:C50501 AV Block Third Degree NCIT:C50501 Atrioventricular block, third degree NCIT:C50501 Complete AV Block NCIT:C50501 Complete atrioventricular block NCIT:C50501 Complete heart block NCIT:C50501 Non-congenital complete atrioventricular block NCIT:C50501 Third Degree AV Block NCIT:C50501 Third degree atrioventricular block NCIT:C50501 A disorder characterized by a dysrhythmia with a delay in the time required for the conduction of an electrical impulse through the atrioventricular (AV) node beyond 0.2 seconds; prolongation of the PR interval greater than 200 milliseconds OR A disorder characterized by an electrocardiographic finding of prolonged PR interval for a specific population. For adults one common threshold is a PR interval greater than 0.20 seconds. CCTO:000370 implies CCTO:000049 CCTO:000370 implies CCTO:001113 CCTO:000370(time_t t0) = EVENT_STATE(CCTO:000370, t0) NCI:CTCAE:10003674 NCIT:C62015 UMLS:C0085614 UMLS:C3715208 AV Block First Degree Atrioventricular block, first degree First Degree AV Block First degree atrioventricular block cancer_care_treatment_outcome CCTO:000370 Atrioventricular block first degree CCTO:000370 A disorder characterized by a dysrhythmia with a delay in the time required for the conduction of an electrical impulse through the atrioventricular (AV) node beyond 0.2 seconds; prolongation of the PR interval greater than 200 milliseconds OR A disorder characterized by an electrocardiographic finding of prolonged PR interval for a specific population. For adults one common threshold is a PR interval greater than 0.20 seconds. NCI:CTCAE NCIT:C62015 AV Block First Degree NCIT:C62015 Atrioventricular block, first degree NCIT:C62015 First Degree AV Block NCIT:C62015 First degree atrioventricular block NCIT:C62015 Paroxysms of chest pain due to reduced oxygen to the heart OR A disorder characterized by substernal discomfort due to insufficient myocardial oxygenation. CCTO:000371 implies CCTO:000107 CCTO:000371 implies CCTO:001113 CCTO:000371(time_t t0) = EVENT_STATE(CCTO:000371, t0) NCI:CTCAE:10008481 NCIT:C51221 UMLS:C0002962 UMLS:C2926611 Angina Angina pectoris cancer_care_treatment_outcome CCTO:000371 Chest pain - cardiac CCTO:000371 Paroxysms of chest pain due to reduced oxygen to the heart OR A disorder characterized by substernal discomfort due to insufficient myocardial oxygenation. NCI:CTCAE NCIT:C51221 Angina NCIT:C51221 Angina pectoris NCIT:C51221 A disorder affecting the conduction system that sends electrical signals in the myocardium OR A disorder characterized by pathological irregularities in the cardiac conduction system. CCTO:000372 implies CCTO:000049 CCTO:000372 implies CCTO:001113 CCTO:000372(time_t t0) = EVENT_STATE(CCTO:000372, t0) NCI:CTCAE:10010276 NCIT:C78245 UMLS:C0264886 Cardiac conduction disorder Disorder of Cardiac Conduction Heart conduction disorder cancer_care_treatment_outcome CCTO:000372 Conduction disorder CCTO:000372 A disorder affecting the conduction system that sends electrical signals in the myocardium OR A disorder characterized by pathological irregularities in the cardiac conduction system. NCI:CTCAE NCIT:C78245 Cardiac conduction disorder NCIT:C78245 Disorder of Cardiac Conduction NCIT:C78245 Heart conduction disorder NCIT:C78245 A disorder characterized by a thickened and fibrotic pericardial sac; these fibrotic changes impede normal myocardial function by restricting myocardial muscle action OR A heart disorder in which the pericardial sac becomes thickened and fibrotic, tightening the myocardium and impeding the normal myocardial function. CCTO:000373 implies CCTO:000049 CCTO:000373 implies CCTO:001113 CCTO:000373(time_t t0) = EVENT_STATE(CCTO:000373, t0) NCI:CTCAE:10010783 NCIT:C78246 UMLS:C0031048 cancer_care_treatment_outcome CCTO:000373 Constrictive pericarditis CCTO:000373 A disorder characterized by a thickened and fibrotic pericardial sac; these fibrotic changes impede normal myocardial function by restricting myocardial muscle action OR A heart disorder in which the pericardial sac becomes thickened and fibrotic, tightening the myocardium and impeding the normal myocardial function. NCI:CTCAE NCIT:C78246 A disorder characterized by the inability of the heart to pump blood at an adequate volume to meet tissue metabolic requirements, or, the ability to do so only at an elevation in the filling pressure OR Inability of the heart to pump blood at an adequate rate to meet tissue metabolic requirements. Clinical symptoms of heart failure include: unusual dyspnea on light exertion, recurrent dyspnea occurring in the supine position, fluid retention or rales, jugular venous distension, pulmonary edema on physical exam, or pulmonary edema on chest x-ray presumed to be cardiac dysfunction. CCTO:000374 implies CCTO:000049 CCTO:000374 implies CCTO:001113 CCTO:000374(time_t t0) = EVENT_STATE(CCTO:000374, t0) NCI:CTCAE:10019279 NCIT:C50577 UMLS:C0018801 UMLS:C0018802 Cardiac failure Cardiac insufficiency Failure, heart Insufficiency, cardiac cancer_care_treatment_outcome CCTO:000374 Heart failure CCTO:000374 A disorder characterized by the inability of the heart to pump blood at an adequate volume to meet tissue metabolic requirements, or, the ability to do so only at an elevation in the filling pressure OR Inability of the heart to pump blood at an adequate rate to meet tissue metabolic requirements. Clinical symptoms of heart failure include: unusual dyspnea on light exertion, recurrent dyspnea occurring in the supine position, fluid retention or rales, jugular venous distension, pulmonary edema on physical exam, or pulmonary edema on chest x-ray presumed to be cardiac dysfunction. NCI:CTCAE NCIT:C50577 Cardiac failure NCIT:C50577 Cardiac insufficiency NCIT:C50577 Failure, heart NCIT:C50577 Insufficiency, cardiac NCIT:C50577 A disorder characterized by failure of the left ventricle to produce adequate output despite an increase in distending pressure and in end-diastolic volume. Clinical manifestations may include dyspnea, orthopnea, and other signs and symptoms of pulmonary congestion and edema OR The degree of impairment of the left cardiac ventricle to contract efficiently. (ACC) OR Defined in terms of ejection fraction, a good clinical indicator of ventricular systolic function. Normal ejection fraction is 0.50 or more (>50%). Left ventricular systolic dysfunction is generally defined as an ejection fraction equal to or less than 0.40 (<40%). CCTO:000375 implies CCTO:000049 CCTO:000375 implies CCTO:001113 CCTO:000375(time_t t0) = EVENT_STATE(CCTO:000375, t0) NCI:CTCAE:10069501 NCIT:C55063 NCIT:C64251 UMLS:C1277187 UMLS:C1963159 Left cardiac ventricular systolic dysfunction Left ventricular systolic dysfunction adverse event cancer_care_treatment_outcome CCTO:000375 Left ventricular systolic dysfunction CCTO:000375 A disorder characterized by failure of the left ventricle to produce adequate output despite an increase in distending pressure and in end-diastolic volume. Clinical manifestations may include dyspnea, orthopnea, and other signs and symptoms of pulmonary congestion and edema OR The degree of impairment of the left cardiac ventricle to contract efficiently. (ACC) OR Defined in terms of ejection fraction, a good clinical indicator of ventricular systolic function. Normal ejection fraction is 0.50 or more (>50%). Left ventricular systolic dysfunction is generally defined as an ejection fraction equal to or less than 0.40 (<40%). NCI:CTCAE NCIT:C55063 NCIT:C64251 Left cardiac ventricular systolic dysfunction NCIT:C64251 Left ventricular systolic dysfunction adverse event NCIT:C55063 A heart disorder characterized by a defect in mitral valve structure or function OR A disorder characterized by a defect in mitral valve function or structure. CCTO:000376 implies CCTO:000049 CCTO:000376 implies CCTO:001113 CCTO:000376(time_t t0) = EVENT_STATE(CCTO:000376, t0) NCI:CTCAE:10061532 NCIT:C78446 UMLS:C0026265 Mitral valve disorder cancer_care_treatment_outcome CCTO:000376 Mitral valve disease CCTO:000376 A heart disorder characterized by a defect in mitral valve structure or function OR A disorder characterized by a defect in mitral valve function or structure. NCI:CTCAE NCIT:C78446 Mitral valve disorder NCIT:C78446 A disorder characterized by a dysrhythmia with relatively constant PR interval prior to the block of an atrial impulse. This is the result of intermittent failure of atrial electrical impulse conduction through the atrioventricular (AV) node to the ventricles OR A disorder characterized by an electrocardiographic finding of intermittent failure of atrial electrical impulse conduction to the ventricles, characterized by a relatively constant PR interval prior to the block of an atrial impulse. (CDISC) CCTO:000377 implies CCTO:000049 CCTO:000377 implies CCTO:001113 CCTO:000377(time_t t0) = EVENT_STATE(CCTO:000377, t0) NCI:CTCAE:10027786 NCIT:C62018 UMLS:C0155700 UMLS:C3811815 AV Block Second Degree Mobitz Type II AV Block Second Degree Möbitz Type II Mobitz (type) II atrioventricular block Mobitz II Mobitz Type II Second Degree AV Block Möbitz II Möbitz Type II Second Degree AV Block Second Degree Atrioventricular Block Mobitz Type II Second Degree Atrioventricular Block Möbitz Type II Type 2 2nd degree AV Block Type 2 Second Degree AV Block Type II Second Degree AV Block Type II Second Degree Atrioventricular Block cancer_care_treatment_outcome CCTO:000377 Mobitz (type) II atrioventricular block CCTO:000377 A disorder characterized by a dysrhythmia with relatively constant PR interval prior to the block of an atrial impulse. This is the result of intermittent failure of atrial electrical impulse conduction through the atrioventricular (AV) node to the ventricles OR A disorder characterized by an electrocardiographic finding of intermittent failure of atrial electrical impulse conduction to the ventricles, characterized by a relatively constant PR interval prior to the block of an atrial impulse. (CDISC) NCI:CTCAE NCIT:C62018 AV Block Second Degree Mobitz Type II NCIT:C62018 AV Block Second Degree Möbitz Type II NCIT:C62018 Mobitz (type) II atrioventricular block NCIT:C62018 Mobitz II NCIT:C62018 Mobitz Type II Second Degree AV Block NCIT:C62018 Möbitz II NCIT:C62018 Möbitz Type II Second Degree AV Block NCIT:C62018 Second Degree Atrioventricular Block Mobitz Type II NCIT:C62018 Second Degree Atrioventricular Block Möbitz Type II NCIT:C62018 Type 2 2nd degree AV Block NCIT:C62018 Type 2 Second Degree AV Block NCIT:C62018 Type II Second Degree AV Block NCIT:C62018 Type II Second Degree Atrioventricular Block NCIT:C62018 A disorder characterized by a dysrhythmia with a progressively lengthening PR interval prior to the blocking of an atrial impulse. This is the result of intermittent failure of atrial electrical impulse conduction through the atrioventricular (AV) node to the ventricles OR A disorder characterized by an electrocardiographic finding of intermittent failure of atrial electrical impulse conduction to the ventricles, characterized by a progressively lengthening PR interval prior to the block of an atrial impulse. (CDISC) CCTO:000378 implies CCTO:000049 CCTO:000378 implies CCTO:001113 CCTO:000378(time_t t0) = EVENT_STATE(CCTO:000378, t0) NCI:CTCAE:10027787 NCIT:C62017 UMLS:C0264907 UMLS:C3811814 AV Block Second Degree Mobitz Type I AV Block Second Degree Möbitz Type I Mobitz I Mobitz Type I Second Degree AV Block Möbitz I Möbitz Type I Second Degree AV Block Second Degree Atrioventricular Block Mobitz Type I Second Degree Atrioventricular Block Möbitz Type I Type 1 2nd degree AV Block Type 1 Second Degree AV Block Type 1 Second Degree Atrioventricular Block Wenckebach block cancer_care_treatment_outcome CCTO:000378 Mobitz type I CCTO:000378 A disorder characterized by a dysrhythmia with a progressively lengthening PR interval prior to the blocking of an atrial impulse. This is the result of intermittent failure of atrial electrical impulse conduction through the atrioventricular (AV) node to the ventricles OR A disorder characterized by an electrocardiographic finding of intermittent failure of atrial electrical impulse conduction to the ventricles, characterized by a progressively lengthening PR interval prior to the block of an atrial impulse. (CDISC) NCI:CTCAE NCIT:C62017 AV Block Second Degree Mobitz Type I NCIT:C62017 AV Block Second Degree Möbitz Type I NCIT:C62017 Mobitz I NCIT:C62017 Mobitz Type I Second Degree AV Block NCIT:C62017 Möbitz I NCIT:C62017 Möbitz Type I Second Degree AV Block NCIT:C62017 Second Degree Atrioventricular Block Mobitz Type I NCIT:C62017 Second Degree Atrioventricular Block Möbitz Type I NCIT:C62017 Type 1 2nd degree AV Block NCIT:C62017 Type 1 Second Degree AV Block NCIT:C62017 Type 1 Second Degree Atrioventricular Block NCIT:C62017 Wenckebach block NCIT:C62017 A disorder characterized by gross necrosis of the myocardium; this is due to an interruption of blood supply to the area OR An electrocardiographic assessment of findings that suggest the occurrence of a myocardial infarction OR An electrocardiographic finding of pathologic Q waves, which is suggestive of myocardial infarction of one or more regions of the heart. No specification is provided for localization. (CDISC) OR Gross necrosis of the myocardium, as a result of interruption of the blood supply to the area, as in coronary thrombosis. CCTO:000379 implies CCTO:000049 CCTO:000379 implies CCTO:001113 CCTO:000379(time_t t0) = EVENT_STATE(CCTO:000379, t0) NCI:CTCAE:10028596 NCIT:C101589 NCIT:C111280 NCIT:C27996 UMLS:C0027051 UMLS:C0428953 UMLS:C3810814 Heart attack Infarction (MI), Myocardial MI MI, Myocardial Infarction Myocardial Infarction ECG Assessment Myocardial Infarction by ECG Finding Myocardial Infarction by EKG Finding Myocardial Infarction, (MI) Myocardial infarct cancer_care_treatment_outcome CCTO:000379 Myocardial infarction CCTO:000379 A disorder characterized by gross necrosis of the myocardium; this is due to an interruption of blood supply to the area OR An electrocardiographic assessment of findings that suggest the occurrence of a myocardial infarction OR An electrocardiographic finding of pathologic Q waves, which is suggestive of myocardial infarction of one or more regions of the heart. No specification is provided for localization. (CDISC) OR Gross necrosis of the myocardium, as a result of interruption of the blood supply to the area, as in coronary thrombosis. NCI:CTCAE NCIT:C101589 NCIT:C111280 NCIT:C27996 Heart attack NCIT:C27996 Infarction (MI), Myocardial NCIT:C27996 MI NCIT:C111280 MI NCIT:C27996 MI, Myocardial Infarction NCIT:C27996 Myocardial Infarction ECG Assessment NCIT:C111280 Myocardial Infarction by ECG Finding NCIT:C101589 Myocardial Infarction by EKG Finding NCIT:C101589 Myocardial Infarction, (MI) NCIT:C27996 Myocardial infarct NCIT:C27996 Inflammation of the muscle tissue of the heart OR A disorder characterized by inflammation of the muscle tissue of the heart. CCTO:000380 implies CCTO:000049 CCTO:000380 implies CCTO:001113 CCTO:000380(time_t t0) = EVENT_STATE(CCTO:000380, t0) NCI:CTCAE:10028606 NCIT:C34831 NCIT:C55064 UMLS:C0027059 UMLS:C1962971 Myocarditis adverse event cancer_care_treatment_outcome CCTO:000380 Myocarditis CCTO:000380 Inflammation of the muscle tissue of the heart OR A disorder characterized by inflammation of the muscle tissue of the heart. NCI:CTCAE NCIT:C34831 Myocarditis adverse event NCIT:C55064 An unpleasant sensation of irregular and/or forceful beating of the heart OR A disorder characterized by an unpleasant sensation of irregular and/or forceful beating of the heart. CCTO:000381 implies CCTO:000049 CCTO:000381 implies CCTO:001113 CCTO:000381(time_t t0) = EVENT_STATE(CCTO:000381, t0) NCI:CTCAE:10033557 NCIT:C37999 NCIT:C54935 UMLS:C0030252 UMLS:C3160712 Palpitation Palpitations adverse event cancer_care_treatment_outcome CCTO:000381 Palpitations CCTO:000381 An unpleasant sensation of irregular and/or forceful beating of the heart OR A disorder characterized by an unpleasant sensation of irregular and/or forceful beating of the heart. NCI:CTCAE NCIT:C37999 Palpitation NCIT:C37999 Palpitations adverse event NCIT:C54935 A disorder characterized by a dysrhythmia with abrupt onset and sudden termination of atrial contractions with a rate of 150-250 beats per minute. The rhythm disturbance originates in the atria OR A disorder characterized by an electrocardiographic finding of episodic atrial tachycardia with abrupt onset and termination. CCTO:000382 implies CCTO:000049 CCTO:000382 implies CCTO:001113 CCTO:000382(time_t t0) = EVENT_STATE(CCTO:000382, t0) NCI:CTCAE:10034040 NCIT:C34900 UMLS:C0030587 UMLS:C2247346 UMLS:C2248827 PAT True paroxysmal atrial tachycardia cancer_care_treatment_outcome CCTO:000382 Paroxysmal atrial tachycardia CCTO:000382 A disorder characterized by a dysrhythmia with abrupt onset and sudden termination of atrial contractions with a rate of 150-250 beats per minute. The rhythm disturbance originates in the atria OR A disorder characterized by an electrocardiographic finding of episodic atrial tachycardia with abrupt onset and termination. NCI:CTCAE NCIT:C34900 PAT NCIT:C34900 True paroxysmal atrial tachycardia NCIT:C34900 Fluid collection within the pericardial sac, usually due to inflammation OR A disorder characterized by fluid collection within the pericardial sac, usually due to inflammation. CCTO:000383 implies CCTO:000049 CCTO:000383 implies CCTO:001113 CCTO:000383(time_t t0) = EVENT_STATE(CCTO:000383, t0) NCI:CTCAE:10034474 NCIT:C3319 UMLS:C0031039 UMLS:C0225973 UMLS:C1253937 UMLS:C1546730 FLUID, PERICARDIAL Pericardial fluid cancer_care_treatment_outcome CCTO:000383 Pericardial effusion CCTO:000383 Fluid collection within the pericardial sac, usually due to inflammation OR A disorder characterized by fluid collection within the pericardial sac, usually due to inflammation. NCI:CTCAE NCIT:C3319 FLUID, PERICARDIAL NCIT:C3319 Pericardial fluid NCIT:C3319 A disorder characterized by an increase in intrapericardial pressure due to the collection of blood or fluid in the pericardium OR Acute compression of the heart caused by increased intrapericardial pressure due to the collection of blood or fluid in the pericardium from rupture of the heart, penetrating trauma, or progressive effusion. CCTO:000384 implies CCTO:000049 CCTO:000384 implies CCTO:001113 CCTO:000384(time_t t0) = EVENT_STATE(CCTO:000384, t0) NCI:CTCAE:10053565 NCIT:C50481 UMLS:C0007177 Cardiac tamponade cancer_care_treatment_outcome CCTO:000384 Pericardial tamponade CCTO:000384 A disorder characterized by an increase in intrapericardial pressure due to the collection of blood or fluid in the pericardium OR Acute compression of the heart caused by increased intrapericardial pressure due to the collection of blood or fluid in the pericardium from rupture of the heart, penetrating trauma, or progressive effusion. NCI:CTCAE NCIT:C50481 Cardiac tamponade NCIT:C50481 A disorder characterized by irritation to the layers of the pericardium (the protective sac around the heart) OR An inflammatory process affecting the pericardium. CCTO:000385 implies CCTO:000049 CCTO:000385 implies CCTO:001113 CCTO:000385(time_t t0) = EVENT_STATE(CCTO:000385, t0) NCI:CTCAE:10034484 NCIT:C34915 NCIT:C55067 UMLS:C0031046 UMLS:C1963211 Pericarditis adverse event cancer_care_treatment_outcome CCTO:000385 Pericarditis CCTO:000385 A disorder characterized by irritation to the layers of the pericardium (the protective sac around the heart) OR An inflammatory process affecting the pericardium. NCI:CTCAE NCIT:C34915 Pericarditis adverse event NCIT:C55067 A heart disorder characterized by a defect in pulmonary valve structure or function OR A disorder characterized by a defect in pulmonary valve function or structure. CCTO:000386 implies CCTO:000049 CCTO:000386 implies CCTO:001113 CCTO:000386(time_t t0) = EVENT_STATE(CCTO:000386, t0) NCI:CTCAE:10061541 NCIT:C78579 UMLS:C0034087 Pulmonary valve disorder cancer_care_treatment_outcome CCTO:000386 Pulmonary valve disease CCTO:000386 A heart disorder characterized by a defect in pulmonary valve structure or function OR A disorder characterized by a defect in pulmonary valve function or structure. NCI:CTCAE NCIT:C78579 Pulmonary valve disorder NCIT:C78579 A disorder characterized by an inability of the ventricles to fill with blood because the myocardium (heart muscle) stiffens and loses its flexibility OR Restrictive cardiomyopathy resulting from a known treatment OR A type of heart disorder referring to the inability of the ventricles to fill with blood because the myocardium (heart muscle) stiffens and looses its flexibility. Causes include replacement of the myocardium with scar tissue, abnormal cellular infiltration of the myocardium, or deposition of a substance (e.g., amyloid) in the myocardium. CCTO:000387 implies CCTO:000049 CCTO:000387 implies CCTO:001113 CCTO:000387(time_t t0) = EVENT_STATE(CCTO:000387, t0) NCI:CTCAE:10038748 NCIT:C55069 NCIT:C62798 UMLS:C0007196 UMLS:C1963079 Restrictive cardiomyopathy adverse event cancer_care_treatment_outcome CCTO:000387 Restrictive cardiomyopathy CCTO:000387 A disorder characterized by an inability of the ventricles to fill with blood because the myocardium (heart muscle) stiffens and loses its flexibility OR Restrictive cardiomyopathy resulting from a known treatment OR A type of heart disorder referring to the inability of the ventricles to fill with blood because the myocardium (heart muscle) stiffens and looses its flexibility. Causes include replacement of the myocardium with scar tissue, abnormal cellular infiltration of the myocardium, or deposition of a substance (e.g., amyloid) in the myocardium. NCI:CTCAE NCIT:C55069 NCIT:C62798 Restrictive cardiomyopathy adverse event NCIT:C55069 A disorder characterized by impairment of right ventricular function associated with low ejection fraction and a decrease in motility of the right ventricular wall OR Impairment of the right ventricular function associated with low ejection fraction and decreased motility of the right ventricular wall. CCTO:000388 implies CCTO:000049 CCTO:000388 implies CCTO:001113 CCTO:000388(time_t t0) = EVENT_STATE(CCTO:000388, t0) NCI:CTCAE:10058597 NCIT:C50733 UMLS:C0242707 Dysfunction, right ventricular cancer_care_treatment_outcome CCTO:000388 Right ventricular dysfunction CCTO:000388 A disorder characterized by impairment of right ventricular function associated with low ejection fraction and a decrease in motility of the right ventricular wall OR Impairment of the right ventricular function associated with low ejection fraction and decreased motility of the right ventricular wall. NCI:CTCAE NCIT:C50733 Dysfunction, right ventricular NCIT:C50733 A disorder characterized by a dysrhythmia with alternating periods of bradycardia and atrial tachycardia accompanied by syncope, fatigue and dizziness OR A constellation of signs and symptoms which may include syncope, fatigue, dizziness, and alternating periods of bradycardia and atrial tachycardia, which is caused by sinoatrial node dysfunction. CCTO:000389 implies CCTO:000049 CCTO:000389 implies CCTO:001113 CCTO:000389(time_t t0) = EVENT_STATE(CCTO:000389, t0) NCI:CTCAE:10040639 NCIT:C54938 NCIT:C62244 UMLS:C0037052 UMLS:C0723181 UMLS:C1963235 SSS Sick sinus syndrome adverse event cancer_care_treatment_outcome CCTO:000389 Sick sinus syndrome CCTO:000389 A disorder characterized by a dysrhythmia with alternating periods of bradycardia and atrial tachycardia accompanied by syncope, fatigue and dizziness OR A constellation of signs and symptoms which may include syncope, fatigue, dizziness, and alternating periods of bradycardia and atrial tachycardia, which is caused by sinoatrial node dysfunction. NCI:CTCAE NCIT:C62244 SSS NCIT:C62244 Sick sinus syndrome adverse event NCIT:C54938 A disorder characterized by an electrocardiographic finding of abnormally slow heart rate with its origin in the sinus node. Thresholds for different age, gender, and patient populations exist. (CDISC) OR An electrocardiographic finding of abnormally slow heart rate with its origin in the sinus node. Thresholds for different age, gender, and patient populations exist. (CDISC) OR A disorder characterized by a dysrhythmia with a heart rate less than 60 beats per minute that originates in the sinus node. CCTO:000390 implies CCTO:000049 CCTO:000390 implies CCTO:001113 CCTO:000390(time_t t0) = EVENT_STATE(CCTO:000390, t0) NCI:CTCAE:10040741 NCIT:C111097 NCIT:C26923 NCIT:C54940 UMLS:C0085610 UMLS:C1963175 UMLS:C2108107 Sinus Bradycardia by ECG Finding Sinus Bradycardia by EKG Finding Sinus bradycardia adverse event cancer_care_treatment_outcome CCTO:000390 Sinus bradycardia CCTO:000390 A disorder characterized by an electrocardiographic finding of abnormally slow heart rate with its origin in the sinus node. Thresholds for different age, gender, and patient populations exist. (CDISC) OR An electrocardiographic finding of abnormally slow heart rate with its origin in the sinus node. Thresholds for different age, gender, and patient populations exist. (CDISC) OR A disorder characterized by a dysrhythmia with a heart rate less than 60 beats per minute that originates in the sinus node. NCI:CTCAE NCIT:C111097 NCIT:C26923 Sinus Bradycardia by ECG Finding NCIT:C111097 Sinus Bradycardia by EKG Finding NCIT:C111097 Sinus bradycardia adverse event NCIT:C54940 A disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates in the sinus node OR A disorder characterized by an electrocardiographic finding of abnormally rapid heart rate with its origin in the sinus node. Thresholds for different age, gender, and patient populations exist. (CDISC) OR An electrocardiographic finding of abnormally rapid heart rate with its origin in the sinus node. Thresholds for different age, gender, and patient populations exist. (CDISC) CCTO:000391 implies CCTO:000049 CCTO:000391 implies CCTO:001113 CCTO:000391(time_t t0) = EVENT_STATE(CCTO:000391, t0) NCI:CTCAE:10040752 NCIT:C111104 NCIT:C26889 NCIT:C54941 UMLS:C0039239 UMLS:C1963246 UMLS:C2108109 Sinus Tachycardia by ECG Finding Sinus Tachycardia by EKG Finding Sinus tachycardia adverse event cancer_care_treatment_outcome CCTO:000391 Sinus tachycardia CCTO:000391 A disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates in the sinus node OR A disorder characterized by an electrocardiographic finding of abnormally rapid heart rate with its origin in the sinus node. Thresholds for different age, gender, and patient populations exist. (CDISC) OR An electrocardiographic finding of abnormally rapid heart rate with its origin in the sinus node. Thresholds for different age, gender, and patient populations exist. (CDISC) NCI:CTCAE NCIT:C111104 NCIT:C26889 Sinus Tachycardia by ECG Finding NCIT:C111104 Sinus Tachycardia by EKG Finding NCIT:C111104 Sinus tachycardia adverse event NCIT:C54941 A disorder characterized by an electrocardiographic finding of a tachycardia which does not originate in the ventricles or His Purkinje system. There is an abnormally high heart rate and QRS complexes are typically narrow, but aberration or preexcitation may be present. (CDISC) OR An electrocardiographic finding of a tachycardia which does not originate in the ventricles or His Purkinje system. There is an abnormally high heart rate and QRS complexes are typically narrow, but aberration or preexcitation may be present. (CDISC) OR A disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates above the ventricles. CCTO:000392 implies CCTO:000049 CCTO:000392 implies CCTO:001113 CCTO:000392(time_t t0) = EVENT_STATE(CCTO:000392, t0) NCI:CTCAE:10042604 NCIT:C111100 NCIT:C35061 NCIT:C54945 UMLS:C0039240 UMLS:C1963244 UMLS:C3815188 SVT Supraventricular Tachycardia by ECG Finding Supraventricular Tachycardia by EKG Finding Supraventricular tachycardia adverse event cancer_care_treatment_outcome CCTO:000392 Supraventricular tachycardia CCTO:000392 A disorder characterized by an electrocardiographic finding of a tachycardia which does not originate in the ventricles or His Purkinje system. There is an abnormally high heart rate and QRS complexes are typically narrow, but aberration or preexcitation may be present. (CDISC) OR An electrocardiographic finding of a tachycardia which does not originate in the ventricles or His Purkinje system. There is an abnormally high heart rate and QRS complexes are typically narrow, but aberration or preexcitation may be present. (CDISC) OR A disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates above the ventricles. NCI:CTCAE NCIT:C111100 NCIT:C35061 SVT NCIT:C111100 SVT NCIT:C35061 Supraventricular Tachycardia by ECG Finding NCIT:C111100 Supraventricular Tachycardia by EKG Finding NCIT:C111100 Supraventricular tachycardia adverse event NCIT:C54945 A disorder characterized by a defect in tricuspid valve function or structure OR A heart disorder characterized by a defect in tricuspid valve structure or function. CCTO:000393 implies CCTO:000049 CCTO:000393 implies CCTO:001113 CCTO:000393(time_t t0) = EVENT_STATE(CCTO:000393, t0) NCI:CTCAE:10061389 NCIT:C78649 UMLS:C0264776 UMLS:C0264882 Tricuspid valve disorder cancer_care_treatment_outcome CCTO:000393 Tricuspid valve disease CCTO:000393 A disorder characterized by a defect in tricuspid valve function or structure OR A heart disorder characterized by a defect in tricuspid valve structure or function. NCI:CTCAE NCIT:C78649 Tricuspid valve disorder NCIT:C78649 An electrocardiographic finding of an atypical cardiac rhythm resulting from a pathologic process in the cardiac ventricles OR A disorder characterized by an electrocardiographic finding of an atypical cardiac rhythm resulting from a pathologic process in the cardiac ventricles OR A disorder characterized by a dysrhythmia that originates in the ventricles. CCTO:000394 implies CCTO:000049 CCTO:000394 implies CCTO:001113 CCTO:000394(time_t t0) = EVENT_STATE(CCTO:000394, t0) NCI:CTCAE:10047281 NCIT:C111101 NCIT:C26924 NCIT:C53844 UMLS:C0085612 UMLS:C0344424 UMLS:C1883529 Ventricular Arrhythmia by ECG Finding Ventricular Arrhythmia by EKG Finding Ventricular arrhythmia adverse event cancer_care_treatment_outcome CCTO:000394 Ventricular arrhythmia CCTO:000394 An electrocardiographic finding of an atypical cardiac rhythm resulting from a pathologic process in the cardiac ventricles OR A disorder characterized by an electrocardiographic finding of an atypical cardiac rhythm resulting from a pathologic process in the cardiac ventricles OR A disorder characterized by a dysrhythmia that originates in the ventricles. NCI:CTCAE NCIT:C111101 NCIT:C26924 Ventricular Arrhythmia by ECG Finding NCIT:C111101 Ventricular Arrhythmia by EKG Finding NCIT:C111101 Ventricular arrhythmia adverse event NCIT:C53844 A disorder characterized by an electrocardiographic finding of a rapid grossly irregular ventricular rhythm with marked variability in QRS cycle length, morphology, and amplitude. The rate is typically greater than 300 bpm. (CDISC) OR A disorder characterized by a dysrhythmia without discernible QRS complexes due to rapid repetitive excitation of myocardial fibers without coordinated contraction of the ventricles OR An electrocardiographic finding of a rapid grossly irregular ventricular rhythm with marked variability in QRS cycle length, morphology, and amplitude. The rate is typically greater than 300 bpm. (CDISC) CCTO:000395 implies CCTO:000049 CCTO:000395 implies CCTO:001113 CCTO:000395(time_t t0) = EVENT_STATE(CCTO:000395, t0) NCI:CTCAE:10047290 NCIT:C111102 NCIT:C50799 NCIT:C54950 UMLS:C0042510 UMLS:C0344435 UMLS:C1962976 Fibrillation, ventricular VF VFib Ventricular Fibrillation by ECG Finding Ventricular Fibrillation by EKG Finding Ventricular fibrillation adverse event cancer_care_treatment_outcome CCTO:000395 Ventricular fibrillation CCTO:000395 A disorder characterized by an electrocardiographic finding of a rapid grossly irregular ventricular rhythm with marked variability in QRS cycle length, morphology, and amplitude. The rate is typically greater than 300 bpm. (CDISC) OR A disorder characterized by a dysrhythmia without discernible QRS complexes due to rapid repetitive excitation of myocardial fibers without coordinated contraction of the ventricles OR An electrocardiographic finding of a rapid grossly irregular ventricular rhythm with marked variability in QRS cycle length, morphology, and amplitude. The rate is typically greater than 300 bpm. (CDISC) NCI:CTCAE NCIT:C111102 NCIT:C50799 Fibrillation, ventricular NCIT:C50799 VF NCIT:C111102 VF NCIT:C50799 VFib NCIT:C111102 VFib NCIT:C50799 Ventricular Fibrillation by ECG Finding NCIT:C111102 Ventricular Fibrillation by EKG Finding NCIT:C111102 Ventricular fibrillation adverse event NCIT:C54950 A disorder characterized by an electrocardiographic finding of three or more consecutive complexes of ventricular origin with a rate greater than a certain threshold (100 or 120 beats per minute are commonly used). The QRS complexes are wide and have an abnormal morphology. (CDISC) OR A disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates distal to the bundle of His OR An electrocardiographic finding of three or more consecutive complexes of ventricular organ with a rate greater than a certain threshold (100 or 120 beats per minute are commonly used). The QRS complexes are wide and have an abnormal morphology. (CDISC) CCTO:000396 implies CCTO:000049 CCTO:000396 implies CCTO:001113 CCTO:000396(time_t t0) = EVENT_STATE(CCTO:000396, t0) NCI:CTCAE:10047302 NCIT:C111103 NCIT:C50802 NCIT:C54951 UMLS:C0042514 UMLS:C0344428 UMLS:C1963247 Ventricular Tachycardia by ECG Finding Ventricular Tachycardia by EKG Finding Ventricular tachycardia adverse event cancer_care_treatment_outcome CCTO:000396 Ventricular tachycardia CCTO:000396 A disorder characterized by an electrocardiographic finding of three or more consecutive complexes of ventricular origin with a rate greater than a certain threshold (100 or 120 beats per minute are commonly used). The QRS complexes are wide and have an abnormal morphology. (CDISC) OR A disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates distal to the bundle of His OR An electrocardiographic finding of three or more consecutive complexes of ventricular organ with a rate greater than a certain threshold (100 or 120 beats per minute are commonly used). The QRS complexes are wide and have an abnormal morphology. (CDISC) NCI:CTCAE NCIT:C111103 NCIT:C50802 Ventricular Tachycardia by ECG Finding NCIT:C111103 Ventricular Tachycardia by EKG Finding NCIT:C111103 Ventricular tachycardia adverse event NCIT:C54951 A disorder characterized by the presence of an accessory conductive pathway between the atria and the ventricles that causes premature ventricular activation OR A cardiac conduction disorder characterized by an electrocardiographic finding of ventricular pre-excitation, which is a short PR interval and a long QRS interval with a delta wave. Most individuals are asymptomatic; however they can experience periods of palpitations, shortness of breath or syncope during tachycardic episodes. CCTO:000397 implies CCTO:000049 CCTO:000397 implies CCTO:001113 CCTO:000397(time_t t0) = EVENT_STATE(CCTO:000397, t0) NCI:CTCAE:10048015 NCIT:C35132 NCIT:C54952 UMLS:C0043202 UMLS:C1963282 WPW Wolff-Parkinson-White Syndrome Adverse Event cancer_care_treatment_outcome CCTO:000397 Wolff-Parkinson-White syndrome CCTO:000397 A disorder characterized by the presence of an accessory conductive pathway between the atria and the ventricles that causes premature ventricular activation OR A cardiac conduction disorder characterized by an electrocardiographic finding of ventricular pre-excitation, which is a short PR interval and a long QRS interval with a delta wave. Most individuals are asymptomatic; however they can experience periods of palpitations, shortness of breath or syncope during tachycardic episodes. NCI:CTCAE NCIT:C35132 WPW NCIT:C35132 Wolff-Parkinson-White Syndrome Adverse Event NCIT:C54952 A disorder characterized by a sensation of marked discomfort in the ear OR Painful sensation in the ear region. CCTO:000398 implies CCTO:000107 CCTO:000398 implies CCTO:001114 CCTO:000398(time_t t0) = EVENT_STATE(CCTO:000398, t0) NCI:CTCAE:10014020 NCIT:C37944 UMLS:C0013456 Earache cancer_care_treatment_outcome CCTO:000398 Ear pain CCTO:000398 A disorder characterized by a sensation of marked discomfort in the ear OR Painful sensation in the ear region. NCI:CTCAE NCIT:C37944 Earache NCIT:C37944 A disorder characterized by an infectious process involving the outer ear and ear canal. Contributory factors include excessive water exposure (swimmer's ear infection) and cuts in the ear canal. Symptoms include fullness, itching, swelling and marked discomfort in the ear and ear drainage OR Inflammation of the anatomical structures of the outer ear and ear canal, which is most often caused by an infectious process. Symptoms include erythema, edema, and pain OR Inflammation of the anatomical structures of the outer ear and ear canal secondary to an infectious process. Bacterial etiology is most common, but fungal infection is also possible. Symptoms include erythema, edema, and pain. CCTO:000399 implies CCTO:000049 CCTO:000399 implies CCTO:001114 CCTO:000399 implies CCTO:001119 CCTO:000399(time_t t0) = EVENT_STATE(CCTO:000399, t0) NCI:CTCAE:10033072 NCI:CTCAE:10065837 NCIT:C3299 NCIT:C79601 UMLS:C0021355 UMLS:C0029878 UMLS:C0740437 External ear infection External otitis Infectious otitis externa Inflammation of External Auditory Canal Inflammation of the External Auditory Canal Otitis externa cancer_care_treatment_outcome CCTO:000399 External ear inflammation CCTO:000399 A disorder characterized by an infectious process involving the outer ear and ear canal. Contributory factors include excessive water exposure (swimmer's ear infection) and cuts in the ear canal. Symptoms include fullness, itching, swelling and marked discomfort in the ear and ear drainage OR Inflammation of the anatomical structures of the outer ear and ear canal, which is most often caused by an infectious process. Symptoms include erythema, edema, and pain OR Inflammation of the anatomical structures of the outer ear and ear canal secondary to an infectious process. Bacterial etiology is most common, but fungal infection is also possible. Symptoms include erythema, edema, and pain. NCI:CTCAE NCIT:C3299 NCIT:C79601 External ear infection NCIT:C3299 External otitis NCIT:C79601 Infectious otitis externa NCIT:C3299 Inflammation of External Auditory Canal NCIT:C79601 Inflammation of the External Auditory Canal NCIT:C79601 Otitis externa NCIT:C3299 Painful sensation in the external ear region OR A disorder characterized by a sensation of marked discomfort in the external ear region. CCTO:000400 implies CCTO:000107 CCTO:000400 implies CCTO:001114 CCTO:000400(time_t t0) = EVENT_STATE(CCTO:000400, t0) NCI:CTCAE:10065785 NCIT:C56060 NCIT:C78285 UMLS:C0239223 UMLS:C1963108 External ear pain adverse event cancer_care_treatment_outcome CCTO:000400 External ear pain CCTO:000400 Painful sensation in the external ear region OR A disorder characterized by a sensation of marked discomfort in the external ear region. NCI:CTCAE NCIT:C78285 External ear pain adverse event NCIT:C56060 Partial or complete loss of the ability to detect or understand sounds resulting from damage to the outer, middle, or inner ear structures. Causes include exposure to loud noise, ear infections, injuries to the ear, genetic, and congenital disorders. CCTO:000401 implies CCTO:000049 CCTO:000401 implies CCTO:001114 CCTO:000401(time_t t0) = EVENT_STATE(CCTO:000401, t0) NCI:CTCAE:10019245 NCIT:C50576 UMLS:C1384666 UMLS:C1550444 Hearing impairment Impairment, hearing cancer_care_treatment_outcome CCTO:000401 Hearing impaired CCTO:000401 Partial or complete loss of the ability to detect or understand sounds resulting from damage to the outer, middle, or inner ear structures. Causes include exposure to loud noise, ear infections, injuries to the ear, genetic, and congenital disorders. NCIT:C50576 Hearing impairment NCIT:C50576 Impairment, hearing NCIT:C50576 Inflammation of the anatomical structures of the middle ear secondary to an infectious process. Bacterial etiology is most common, but both viral and fungal pathogens are also possible. Symptoms include erythema and edema of the tympanic membrane, pain, and possibly fever. In severe infections, inflammation and edema of the structures of the middle ear can lead to perforation of the tympanic membrane secondary to the buildup of pressure in the narrow space OR Inflammation of the anatomical structures of the middle ear, which is most often caused by an infectious process. Symptoms include erythema and edema of the tympanic membrane, pain, and possibly fever OR A disorder characterized by an infectious process involving the middle ear. CCTO:000402 implies CCTO:000049 CCTO:000402 implies CCTO:001114 CCTO:000402 implies CCTO:001119 CCTO:000402(time_t t0) = EVENT_STATE(CCTO:000402, t0) NCI:CTCAE:10033078 NCI:CTCAE:10065838 NCIT:C34885 NCIT:C84354 UMLS:C0029882 UMLS:C2827407 Infectious otitis media Medial otitis Middle ear infection Otitis media cancer_care_treatment_outcome CCTO:000402 Middle ear inflammation CCTO:000402 Inflammation of the anatomical structures of the middle ear secondary to an infectious process. Bacterial etiology is most common, but both viral and fungal pathogens are also possible. Symptoms include erythema and edema of the tympanic membrane, pain, and possibly fever. In severe infections, inflammation and edema of the structures of the middle ear can lead to perforation of the tympanic membrane secondary to the buildup of pressure in the narrow space OR Inflammation of the anatomical structures of the middle ear, which is most often caused by an infectious process. Symptoms include erythema and edema of the tympanic membrane, pain, and possibly fever OR A disorder characterized by an infectious process involving the middle ear. NCI:CTCAE NCIT:C34885 NCIT:C84354 Infectious otitis media NCIT:C84354 Medial otitis NCIT:C34885 Middle ear infection NCIT:C84354 Otitis media NCIT:C84354 Abnormal perception of sounds experienced by an individual in the absence of auditory stimulation OR A disorder characterized by noise in the ears, such as ringing, buzzing, roaring or clicking. CCTO:000403 implies CCTO:000049 CCTO:000403 implies CCTO:001114 CCTO:000403(time_t t0) = EVENT_STATE(CCTO:000403, t0) NCI:CTCAE:10043882 NCIT:C50772 NCIT:C54959 UMLS:C0040264 UMLS:C0155533 UMLS:C1963249 Ears, ringing in Ringing in ears Tinnitus adverse event Tinnitus aurium cancer_care_treatment_outcome CCTO:000403 Tinnitus CCTO:000403 Abnormal perception of sounds experienced by an individual in the absence of auditory stimulation OR A disorder characterized by noise in the ears, such as ringing, buzzing, roaring or clicking. NCI:CTCAE NCIT:C50772 Ears, ringing in NCIT:C50772 Ringing in ears NCIT:C50772 Tinnitus adverse event NCIT:C54959 Tinnitus aurium NCIT:C50772 A disorder characterized by a sensation as if the external world were revolving around the patient (objective vertigo) or as if he himself were revolving in space (subjective vertigo) OR A feeling of movement, a sensation as if the external world were revolving around the patient (objective vertigo) or as if he himself were revolving in space (subjective vertigo). Vertigo is medically distinct from dizziness, lightheadedness, and unsteadiness. CCTO:000404 implies CCTO:000049 CCTO:000404 implies CCTO:001114 CCTO:000404(time_t t0) = EVENT_STATE(CCTO:000404, t0) NCI:CTCAE:10047340 NCIT:C38057 UMLS:C0042571 UMLS:C1069915 cancer_care_treatment_outcome CCTO:000404 Vertigo CCTO:000404 A disorder characterized by a sensation as if the external world were revolving around the patient (objective vertigo) or as if he himself were revolving in space (subjective vertigo) OR A feeling of movement, a sensation as if the external world were revolving around the patient (objective vertigo) or as if he himself were revolving in space (subjective vertigo). Vertigo is medically distinct from dizziness, lightheadedness, and unsteadiness. NCI:CTCAE NCIT:C38057 A disorder characterized by dizziness, imbalance, nausea, and vision problems OR A non-neoplastic or neoplastic disorder affecting the inner ear. Causes are inner ear infections, head injuries, and neoplasms (e.g., acoustic schwannoma). Symptoms include dizziness, imbalance, nausea, and vision problems. CCTO:000405 implies CCTO:000049 CCTO:000405 implies CCTO:001114 CCTO:000405(time_t t0) = EVENT_STATE(CCTO:000405, t0) NCI:CTCAE:10047386 NCIT:C27166 UMLS:C0042594 UMLS:C0494559 Inner ear disorder Internal ear disorder cancer_care_treatment_outcome CCTO:000405 Vestibular disorder CCTO:000405 A disorder characterized by dizziness, imbalance, nausea, and vision problems OR A non-neoplastic or neoplastic disorder affecting the inner ear. Causes are inner ear infections, head injuries, and neoplasms (e.g., acoustic schwannoma). Symptoms include dizziness, imbalance, nausea, and vision problems. NCI:CTCAE NCIT:C27166 Inner ear disorder NCIT:C27166 Internal ear disorder NCIT:C27166 An endocrine or hormonal disorder that occurs when the adrenal cortex does not produce enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex (Addison's disease or primary adrenal insufficiency) or to inadequate secretion of ACTH by the pituitary gland (secondary adrenal insufficiency) OR A disorder that occurs when the adrenal cortex does not produce enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex as in Addison's disease or primary adrenal insufficiency. CCTO:000406 implies CCTO:000049 CCTO:000406 implies CCTO:001115 CCTO:000406(time_t t0) = EVENT_STATE(CCTO:000406, t0) NCI:CTCAE:10001367 NCIT:C26691 NCIT:C55748 UMLS:C0001623 UMLS:C0405580 UMLS:C1417838 UMLS:C1963059 Adrenal cortical hypofunction Adrenal cortical insufficiency Adrenal gland insufficiency Adrenal insufficiency adverse event Adrenocortical insufficiency cancer_care_treatment_outcome CCTO:000406 Adrenal insufficiency CCTO:000406 An endocrine or hormonal disorder that occurs when the adrenal cortex does not produce enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex (Addison's disease or primary adrenal insufficiency) or to inadequate secretion of ACTH by the pituitary gland (secondary adrenal insufficiency) OR A disorder that occurs when the adrenal cortex does not produce enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex as in Addison's disease or primary adrenal insufficiency. NCI:CTCAE NCIT:C26691 Adrenal cortical hypofunction NCIT:C26691 Adrenal cortical insufficiency NCIT:C26691 Adrenal gland insufficiency NCIT:C26691 Adrenal insufficiency adverse event NCIT:C55748 Adrenocortical insufficiency NCIT:C26691 A constellation of signs and symptoms caused by an excess of glucocorticoids. Classic features include moon facies, buffalo hump, obesity, striae and adiposity OR A disorder characterized by signs and symptoms that resemble Cushing's disease or syndrome: buffalo hump obesity, striations, adiposity, hypertension, diabetes, and osteoporosis, usually due to exogenous corticosteroids. CCTO:000407 implies CCTO:000049 CCTO:000407 implies CCTO:001115 CCTO:000407(time_t t0) = EVENT_STATE(CCTO:000407, t0) NCI:CTCAE:10011655 NCIT:C37938 UMLS:C0332601 UMLS:C0878661 cancer_care_treatment_outcome CCTO:000407 Cushingoid CCTO:000407 A constellation of signs and symptoms caused by an excess of glucocorticoids. Classic features include moon facies, buffalo hump, obesity, striae and adiposity OR A disorder characterized by signs and symptoms that resemble Cushing's disease or syndrome: buffalo hump obesity, striations, adiposity, hypertension, diabetes, and osteoporosis, usually due to exogenous corticosteroids. NCI:CTCAE NCIT:C37938 A disorder characterized by unusually late sexual maturity OR Unusually late sexual maturity. CCTO:000408 implies CCTO:000049 CCTO:000408 implies CCTO:001115 CCTO:000408(time_t t0) = EVENT_STATE(CCTO:000408, t0) NCI:CTCAE:10012205 NCIT:C62587 UMLS:C0034012 Constitutional growth delay Pubertal delay cancer_care_treatment_outcome CCTO:000408 Delayed puberty CCTO:000408 A disorder characterized by unusually late sexual maturity OR Unusually late sexual maturity. NCI:CTCAE NCIT:C62587 Constitutional growth delay NCIT:C62587 Pubertal delay NCIT:C62587 A finding indicating a faster than normal rate of development OR A disorder characterized by greater growth than expected for age. CCTO:000409 implies CCTO:000049 CCTO:000409 implies CCTO:001115 CCTO:000409(time_t t0) = EVENT_STATE(CCTO:000409, t0) NCI:CTCAE:10018746 NCIT:C83495 UMLS:C0151685 Accelerated growth cancer_care_treatment_outcome CCTO:000409 Growth accelerated CCTO:000409 A finding indicating a faster than normal rate of development OR A disorder characterized by greater growth than expected for age. NCI:CTCAE NCIT:C83495 Accelerated growth NCIT:C83495 A disorder characterized by an increase in production of parathyroid hormone by the parathyroid glands. This results in hypercalcemia (abnormally high levels of calcium in the blood) OR Hyperfunction of the parathyroid glands resulting in the overproduction of parathyroid hormone. It may be primary or secondary; primary hyperparathyroidism is caused by parathyroid adenoma, parathyroid hyperplasia, parathyroid carcinoma, and multiple endocrine neoplasia. It is associated with hypercalcemia and hypophosphatemia. Signs and symptoms include weakness, fatigue, nausea, vomiting, constipation, depression, bone pain, osteoporosis, cystic bone lesions, and kidney stones. Secondary hyperparathyroidism is caused by the chronic stimulation of the parathyroid glands in patients with chronic renal failure, rickets, and malabsorption syndromes. CCTO:000410 implies CCTO:000049 CCTO:000410 implies CCTO:001115 CCTO:000410(time_t t0) = EVENT_STATE(CCTO:000410, t0) NCI:CTCAE:10020705 NCIT:C48259 UMLS:C0020502 cancer_care_treatment_outcome CCTO:000410 Hyperparathyroidism CCTO:000410 A disorder characterized by an increase in production of parathyroid hormone by the parathyroid glands. This results in hypercalcemia (abnormally high levels of calcium in the blood) OR Hyperfunction of the parathyroid glands resulting in the overproduction of parathyroid hormone. It may be primary or secondary; primary hyperparathyroidism is caused by parathyroid adenoma, parathyroid hyperplasia, parathyroid carcinoma, and multiple endocrine neoplasia. It is associated with hypercalcemia and hypophosphatemia. Signs and symptoms include weakness, fatigue, nausea, vomiting, constipation, depression, bone pain, osteoporosis, cystic bone lesions, and kidney stones. Secondary hyperparathyroidism is caused by the chronic stimulation of the parathyroid glands in patients with chronic renal failure, rickets, and malabsorption syndromes. NCI:CTCAE NCIT:C48259 Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor OR A disorder characterized by excessive levels of thyroid hormone in the body. Common causes include an overactive thyroid gland or thyroid hormone overdose. CCTO:000411 implies CCTO:000049 CCTO:000411 implies CCTO:001115 CCTO:000411(time_t t0) = EVENT_STATE(CCTO:000411, t0) NCI:CTCAE:10020850 NCIT:C3123 UMLS:C0020550 Overactive thyroid cancer_care_treatment_outcome CCTO:000411 Hyperthyroidism CCTO:000411 Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor OR A disorder characterized by excessive levels of thyroid hormone in the body. Common causes include an overactive thyroid gland or thyroid hormone overdose. NCI:CTCAE NCIT:C3123 Overactive thyroid NCIT:C3123 An endocrine disorder characterized by decreased production of parathyroid hormone by the parathyroid glands. It is usually caused by damage of the parathyroid glands during head and neck surgery. Signs and symptoms include muscle cramps, abdominal pain, dry skin, brittle nails, cataracts, tetany, and convulsions OR A disorder characterized by a decrease in production of parathyroid hormone by the parathyroid glands. CCTO:000412 implies CCTO:000049 CCTO:000412 implies CCTO:001115 CCTO:000412(time_t t0) = EVENT_STATE(CCTO:000412, t0) NCI:CTCAE:10021041 NCIT:C78350 UMLS:C0020626 cancer_care_treatment_outcome CCTO:000412 Hypoparathyroidism CCTO:000412 An endocrine disorder characterized by decreased production of parathyroid hormone by the parathyroid glands. It is usually caused by damage of the parathyroid glands during head and neck surgery. Signs and symptoms include muscle cramps, abdominal pain, dry skin, brittle nails, cataracts, tetany, and convulsions OR A disorder characterized by a decrease in production of parathyroid hormone by the parathyroid glands. NCI:CTCAE NCIT:C78350 A disorder characterized by a decrease in production of thyroid hormone by the thyroid gland OR Abnormally low levels of thyroid hormone. CCTO:000413 implies CCTO:000049 CCTO:000413 implies CCTO:001115 CCTO:000413(time_t t0) = EVENT_STATE(CCTO:000413, t0) NCI:CTCAE:10021114 NCIT:C26800 UMLS:C0020676 underactive thyroid cancer_care_treatment_outcome CCTO:000413 Hypothyroidism CCTO:000413 A disorder characterized by a decrease in production of thyroid hormone by the thyroid gland OR Abnormally low levels of thyroid hormone. NCI:CTCAE NCIT:C26800 underactive thyroid NCIT:C26800 A disorder characterized by unusually early development of secondary sexual features; the onset of sexual maturation begins usually before age 8 for girls and before age 9 for boys OR Unusually early sexual maturity. CCTO:000414 implies CCTO:000049 CCTO:000414 implies CCTO:001115 CCTO:000414(time_t t0) = EVENT_STATE(CCTO:000414, t0) NCI:CTCAE:10058084 NCIT:C79704 UMLS:C0034013 UMLS:C0271527 Sexual precocity cancer_care_treatment_outcome CCTO:000414 Precocious puberty CCTO:000414 A disorder characterized by unusually early development of secondary sexual features; the onset of sexual maturation begins usually before age 8 for girls and before age 9 for boys OR Unusually early sexual maturity. NCI:CTCAE NCIT:C79704 Sexual precocity NCIT:C79704 A disorder characterized by inappropriate masculinization occurring in a female or prepubertal male OR The development of normal male puberty due to testosterone effect or the abnormal development of male secondary sexual characteristics in children and females due to excessive androgens OR The abnormal development of male secondary sexual characteristics due to excessive androgens. CCTO:000415 implies CCTO:000049 CCTO:000415 implies CCTO:001115 CCTO:000415(time_t t0) = EVENT_STATE(CCTO:000415, t0) NCI:CTCAE:10047488 NCIT:C120262 NCIT:C79859 UMLS:C0042755 Abnormal virilization Masculinization Virilism cancer_care_treatment_outcome CCTO:000415 Virilization CCTO:000415 A disorder characterized by inappropriate masculinization occurring in a female or prepubertal male OR The development of normal male puberty due to testosterone effect or the abnormal development of male secondary sexual characteristics in children and females due to excessive androgens OR The abnormal development of male secondary sexual characteristics due to excessive androgens. NCI:CTCAE NCIT:C120262 NCIT:C79859 Abnormal virilization NCIT:C79859 Masculinization NCIT:C79859 Virilism NCIT:C79859 Blurred vision is the loss of visual acuity (sharpness of vision) resulting in a loss of ability to see small details. (from MedlinePlus Medical Encyclopedia) OR A disorder characterized by visual perception of unclear or fuzzy images. CCTO:000416 implies CCTO:000049 CCTO:000416 implies CCTO:001116 CCTO:000416(time_t t0) = EVENT_STATE(CCTO:000416, t0) NCI:CTCAE:10005886 NCIT:C27123 UMLS:C0344232 Blurring Vision, blurring of cancer_care_treatment_outcome CCTO:000416 Blurred vision CCTO:000416 Blurred vision is the loss of visual acuity (sharpness of vision) resulting in a loss of ability to see small details. (from MedlinePlus Medical Encyclopedia) OR A disorder characterized by visual perception of unclear or fuzzy images. NCI:CTCAE NCIT:C27123 Blurring NCIT:C27123 Vision, blurring of NCIT:C27123 A disorder characterized by partial or complete opacity of the crystalline lens of one or both eyes. This results in a decrease in visual acuity and eventual blindness if untreated OR Partial or complete opacity of the crystalline lens of one or both eyes that decreases visual acuity and eventually results in blindness. Some cataracts appear in infancy or in childhood, but most develop in older individuals. (Sternberg Diagnostic Surgical Pathology, 3rd ed.) CCTO:000417 implies CCTO:000049 CCTO:000417 implies CCTO:001116 CCTO:000417(time_t t0) = EVENT_STATE(CCTO:000417, t0) NCI:CTCAE:10007739 NCIT:C26713 NCIT:C55830 UMLS:C0086543 UMLS:C1962983 Cataract adverse event OPACITY OF THE LENS cancer_care_treatment_outcome CCTO:000417 Cataract CCTO:000417 A disorder characterized by partial or complete opacity of the crystalline lens of one or both eyes. This results in a decrease in visual acuity and eventual blindness if untreated OR Partial or complete opacity of the crystalline lens of one or both eyes that decreases visual acuity and eventually results in blindness. Some cataracts appear in infancy or in childhood, but most develop in older individuals. (Sternberg Diagnostic Surgical Pathology, 3rd ed.) NCI:CTCAE NCIT:C26713 Cataract adverse event NCIT:C55830 OPACITY OF THE LENS NCIT:C26713 A disorder characterized by inflammation, swelling and redness to the conjunctiva of the eye OR Inflammation of the conjunctiva of the eye. CCTO:000418 implies CCTO:000049 CCTO:000418 implies CCTO:001116 CCTO:000418(time_t t0) = EVENT_STATE(CCTO:000418, t0) NCI:CTCAE:10010741 NCIT:C34504 UMLS:C0009763 UMLS:C1313983 Pink eye cancer_care_treatment_outcome CCTO:000418 Conjunctivitis CCTO:000418 A disorder characterized by inflammation, swelling and redness to the conjunctiva of the eye OR Inflammation of the conjunctiva of the eye. NCI:CTCAE NCIT:C34504 Pink eye NCIT:C34504 Area of epithelial tissue loss from corneal surface; associated with inflammatory cells in the cornea and anterior chamber OR A disorder characterized by an area of epithelial tissue loss on the surface of the cornea. It is associated with inflammatory cells in the cornea and anterior chamber. CCTO:000419 implies CCTO:000049 CCTO:000419 implies CCTO:001116 CCTO:000419(time_t t0) = EVENT_STATE(CCTO:000419, t0) NCI:CTCAE:10048492 NCIT:C50515 UMLS:C0010043 Ulcer, corneal cancer_care_treatment_outcome CCTO:000419 Corneal ulcer CCTO:000419 Area of epithelial tissue loss from corneal surface; associated with inflammatory cells in the cornea and anterior chamber OR A disorder characterized by an area of epithelial tissue loss on the surface of the cornea. It is associated with inflammatory cells in the cornea and anterior chamber. NCI:CTCAE NCIT:C50515 Ulcer, corneal NCIT:C50515 A syndrome characterized by dryness of the cornea and conjunctiva. It is usually caused by a deficiency in tear production. Symptoms include a feeling of burning eyes and a possible foreign body presence in the eye OR A disorder characterized by dryness of the cornea and conjunctiva. CCTO:000420 implies CCTO:000049 CCTO:000420 implies CCTO:001116 CCTO:000420(time_t t0) = EVENT_STATE(CCTO:000420, t0) NCI:CTCAE:10013774 NCIT:C34553 UMLS:C0013238 UMLS:C0022575 UMLS:C0314719 Dry Eye(s) Dry eye syndrome Eye(s), Dry Keratoconjunctivitis sicca cancer_care_treatment_outcome CCTO:000420 Dry eye CCTO:000420 A syndrome characterized by dryness of the cornea and conjunctiva. It is usually caused by a deficiency in tear production. Symptoms include a feeling of burning eyes and a possible foreign body presence in the eye OR A disorder characterized by dryness of the cornea and conjunctiva. NCI:CTCAE NCIT:C34553 Dry Eye(s) NCIT:C34553 Dry eye syndrome NCIT:C34553 Eye(s), Dry NCIT:C34553 Keratoconjunctivitis sicca NCIT:C34553 A slight or incomplete paralysis of an extraocular muscle OR A disorder characterized by incomplete paralysis of an extraocular muscle. CCTO:000421 implies CCTO:000049 CCTO:000421 implies CCTO:001116 CCTO:000421(time_t t0) = EVENT_STATE(CCTO:000421, t0) NCI:CTCAE:10015829 NCIT:C78286 UMLS:C0262918 cancer_care_treatment_outcome CCTO:000421 Extraocular muscle paresis CCTO:000421 A slight or incomplete paralysis of an extraocular muscle OR A disorder characterized by incomplete paralysis of an extraocular muscle. NCI:CTCAE NCIT:C78286 Painful sensation in the eye OR A disorder characterized by a sensation of marked discomfort in the eye. CCTO:000422 implies CCTO:000107 CCTO:000422 implies CCTO:001116 CCTO:000422(time_t t0) = EVENT_STATE(CCTO:000422, t0) NCI:CTCAE:10015958 NCIT:C56070 NCIT:C78287 UMLS:C0151827 UMLS:C1959630 Eye pain adverse event cancer_care_treatment_outcome CCTO:000422 Eye pain CCTO:000422 Painful sensation in the eye OR A disorder characterized by a sensation of marked discomfort in the eye. NCI:CTCAE NCIT:C78287 Eye pain adverse event NCIT:C56070 A disorder characterized by impaired eyelid function OR A disorder characterized by impaired eyelid function. CCTO:000423 implies CCTO:000049 CCTO:000423 implies CCTO:001116 CCTO:000423(time_t t0) = EVENT_STATE(CCTO:000423, t0) NCI:CTCAE:10061145 NCIT:C78288 UMLS:C0854286 cancer_care_treatment_outcome CCTO:000423 Eyelid function disorder CCTO:000423 A disorder characterized by impaired eyelid function OR A disorder characterized by impaired eyelid function. NCI:CTCAE NCIT:C78288 A disorder characterized by a sudden or brief burst of light OR The perception of sudden or brief bursts (flashes) of light. CCTO:000424 implies CCTO:000049 CCTO:000424 implies CCTO:001116 CCTO:000424(time_t t0) = EVENT_STATE(CCTO:000424, t0) NCI:CTCAE:10016757 NCIT:C50568 UMLS:C0015269 UMLS:C0085635 UMLS:C1705499 UMLS:C1705500 Flasher Flashers Photopsia cancer_care_treatment_outcome CCTO:000424 Flashing lights CCTO:000424 A disorder characterized by a sudden or brief burst of light OR The perception of sudden or brief bursts (flashes) of light. NCI:CTCAE NCIT:C50568 Flasher NCIT:C50568 Flashers NCIT:C50568 Photopsia NCIT:C50568 Spots before the eyes caused by opaque cell fragments in the vitreous humor or lens OR Spots before the eyes caused by opaque cell fragments in the vitreous humor or lens OR A disorder characterized by an individual seeing spots before their eyes. The spots are shadows of opaque cell fragments in the vitreous humor or lens. CCTO:000425 implies CCTO:000049 CCTO:000425 implies CCTO:001116 CCTO:000425(time_t t0) = EVENT_STATE(CCTO:000425, t0) NCI:CTCAE:10016778 NCIT:C37955 NCIT:C50808 UMLS:C0016242 Floaters, vitreous Vitreous floater Vitreous floaters cancer_care_treatment_outcome CCTO:000425 Floaters CCTO:000425 Spots before the eyes caused by opaque cell fragments in the vitreous humor or lens OR Spots before the eyes caused by opaque cell fragments in the vitreous humor or lens OR A disorder characterized by an individual seeing spots before their eyes. The spots are shadows of opaque cell fragments in the vitreous humor or lens. NCI:CTCAE NCIT:C37955 NCIT:C50808 Floaters, vitreous NCIT:C50808 Vitreous floater NCIT:C50808 Vitreous floaters NCIT:C50808 A disorder characterized by an increase in pressure in the eyeball due to obstruction of the aqueous humor outflow OR Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor. CCTO:000426 implies CCTO:000049 CCTO:000426 implies CCTO:001116 CCTO:000426(time_t t0) = EVENT_STATE(CCTO:000426, t0) NCI:CTCAE:10018304 NCIT:C26782 NCIT:C55842 UMLS:C0017601 UMLS:C1962986 Glaucoma adverse event cancer_care_treatment_outcome CCTO:000426 Glaucoma CCTO:000426 A disorder characterized by an increase in pressure in the eyeball due to obstruction of the aqueous humor outflow OR Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor. NCI:CTCAE NCIT:C26782 Glaucoma adverse event NCIT:C55842 A disorder characterized by inflammation to the cornea of the eye OR Inflammation of the cornea. CCTO:000427 implies CCTO:000049 CCTO:000427 implies CCTO:001116 CCTO:000427(time_t t0) = EVENT_STATE(CCTO:000427, t0) NCI:CTCAE:10023332 NCIT:C26805 UMLS:C0022568 cancer_care_treatment_outcome CCTO:000427 Keratitis CCTO:000427 A disorder characterized by inflammation to the cornea of the eye OR Inflammation of the cornea. NCI:CTCAE NCIT:C26805 A disorder characterized by an inability to see clearly in dim light OR An inability to see clearly in dim light; due to a deficiency of vitamin A or to a retinal disorder. CCTO:000428 implies CCTO:000049 CCTO:000428 implies CCTO:001116 CCTO:000428(time_t t0) = EVENT_STATE(CCTO:000428, t0) NCI:CTCAE:10029404 NCIT:C34850 UMLS:C0028077 Nyctalopia cancer_care_treatment_outcome CCTO:000428 Night blindness CCTO:000428 A disorder characterized by an inability to see clearly in dim light OR An inability to see clearly in dim light; due to a deficiency of vitamin A or to a retinal disorder. NCI:CTCAE NCIT:C34850 Nyctalopia NCIT:C34850 A non-neoplastic or neoplastic disorder affecting the optic nerve (second cranial nerve) OR A disorder characterized by involvement of the optic nerve (second cranial nerve). CCTO:000429 implies CCTO:000049 CCTO:000429 implies CCTO:001116 CCTO:000429(time_t t0) = EVENT_STATE(CCTO:000429, t0) NCI:CTCAE:10061322 NCIT:C79698 UMLS:C0029132 Second cranial nerve disorder cancer_care_treatment_outcome CCTO:000429 Optic nerve disorder CCTO:000429 A non-neoplastic or neoplastic disorder affecting the optic nerve (second cranial nerve) OR A disorder characterized by involvement of the optic nerve (second cranial nerve). NCI:CTCAE NCIT:C79698 Second cranial nerve disorder NCIT:C79698 A disorder characterized by swelling around the optic disc OR Swelling around the optic disc, usually due to increased intracranial pressure or pressure on the optic nerve by a tumor. CCTO:000430 implies CCTO:000049 CCTO:000430 implies CCTO:001116 CCTO:000430(time_t t0) = EVENT_STATE(CCTO:000430, t0) NCI:CTCAE:10033703 NCIT:C3307 UMLS:C0030353 Papilloedema cancer_care_treatment_outcome CCTO:000430 Papilledema CCTO:000430 A disorder characterized by swelling around the optic disc OR Swelling around the optic disc, usually due to increased intracranial pressure or pressure on the optic nerve by a tumor. NCI:CTCAE NCIT:C3307 Papilloedema NCIT:C3307 Increased sensitivity of the eyes to light, which can result in the avoidance of light exposure OR A disorder characterized by fear and avoidance of light. CCTO:000431 implies CCTO:000049 CCTO:000431 implies CCTO:001116 CCTO:000431(time_t t0) = EVENT_STATE(CCTO:000431, t0) NCI:CTCAE:10034960 NCIT:C28210 UMLS:C0085636 Light sensitivity Ocular photosensitivity cancer_care_treatment_outcome CCTO:000431 Photophobia CCTO:000431 Increased sensitivity of the eyes to light, which can result in the avoidance of light exposure OR A disorder characterized by fear and avoidance of light. NCI:CTCAE NCIT:C28210 Light sensitivity NCIT:C28210 Ocular photosensitivity NCIT:C28210 A disorder characterized by the separation of the inner retina layers from the underlying pigment epithelium OR An eye emergency condition which may lead to blindness if left untreated. It is characterized by the separation of the inner retina layers from the underlying pigment epithelium. Causes include trauma, advanced diabetes mellitus, high myopia, and choroid tumors. Symptoms include sudden appearance of floaters, sudden light flushes, and blurred vision. CCTO:000432 implies CCTO:000049 CCTO:000432 implies CCTO:001116 CCTO:000432(time_t t0) = EVENT_STATE(CCTO:000432, t0) NCI:CTCAE:10038848 NCIT:C26874 NCIT:C55886 UMLS:C0035305 UMLS:C1963229 Detached retina Retina, detached Retinal detachment adverse event cancer_care_treatment_outcome CCTO:000432 Retinal detachment CCTO:000432 A disorder characterized by the separation of the inner retina layers from the underlying pigment epithelium OR An eye emergency condition which may lead to blindness if left untreated. It is characterized by the separation of the inner retina layers from the underlying pigment epithelium. Causes include trauma, advanced diabetes mellitus, high myopia, and choroid tumors. Symptoms include sudden appearance of floaters, sudden light flushes, and blurred vision. NCI:CTCAE NCIT:C26874 Detached retina NCIT:C26874 Retina, detached NCIT:C26874 Retinal detachment adverse event NCIT:C55886 A disorder characterized by a small laceration of the retina, this occurs when the vitreous separates from the retina. Symptoms include flashes and floaters OR A usually small tearing of the retina occurring when the vitreous separates from the retina. It may lead to retinal detachment. Symptoms include flashes and floaters. CCTO:000433 implies CCTO:000049 CCTO:000433 implies CCTO:001116 CCTO:000433(time_t t0) = EVENT_STATE(CCTO:000433, t0) NCI:CTCAE:10038897 NCIT:C50732 UMLS:C0035321 Retina, Tear(s) In Retinal tears cancer_care_treatment_outcome CCTO:000433 Retinal tear CCTO:000433 A disorder characterized by a small laceration of the retina, this occurs when the vitreous separates from the retina. Symptoms include flashes and floaters OR A usually small tearing of the retina occurring when the vitreous separates from the retina. It may lead to retinal detachment. Symptoms include flashes and floaters. NCI:CTCAE NCIT:C50732 Retina, Tear(s) In NCIT:C50732 Retinal tears NCIT:C50732 Retinal damage resulting from diminished blood flow/oxygenation due to abnormalities of the retinal vessels. Causes include hypertension, diabetes, thrombosis, embolism, and hemorrhage OR A disorder characterized by pathological retinal blood vessels that adversely affects vision. CCTO:000434 implies CCTO:000049 CCTO:000434 implies CCTO:001116 CCTO:000434(time_t t0) = EVENT_STATE(CCTO:000434, t0) NCI:CTCAE:10038901 NCIT:C35170 UMLS:C0154833 cancer_care_treatment_outcome CCTO:000434 Retinal vascular disorder CCTO:000434 Retinal damage resulting from diminished blood flow/oxygenation due to abnormalities of the retinal vessels. Causes include hypertension, diabetes, thrombosis, embolism, and hemorrhage OR A disorder characterized by pathological retinal blood vessels that adversely affects vision. NCI:CTCAE NCIT:C35170 A disorder involving the retina OR Any disease or disorder of the retina. CCTO:000435 implies CCTO:000049 CCTO:000435 implies CCTO:001116 CCTO:000435(time_t t0) = EVENT_STATE(CCTO:000435, t0) NCI:CTCAE:10038923 NCIT:C55891 NCIT:C62601 UMLS:C0035309 UMLS:C1962966 Retinopathy adverse event cancer_care_treatment_outcome CCTO:000435 Retinopathy CCTO:000435 A disorder involving the retina OR Any disease or disorder of the retina. NCI:CTCAE NCIT:C62601 Retinopathy adverse event NCIT:C55891 A disorder affecting the sclera. Examples include inflammatory processes (e.g., scleritis and episcleritis), and degenerative processes. Primary tumors of the sclera are extremely rare OR A disorder characterized by involvement of the sclera of the eye. CCTO:000436 implies CCTO:000049 CCTO:000436 implies CCTO:001116 CCTO:000436(time_t t0) = EVENT_STATE(CCTO:000436, t0) NCI:CTCAE:10061510 NCIT:C79717 UMLS:C0036412 Sclera disorder cancer_care_treatment_outcome CCTO:000436 Scleral disorder CCTO:000436 A disorder affecting the sclera. Examples include inflammatory processes (e.g., scleritis and episcleritis), and degenerative processes. Primary tumors of the sclera are extremely rare OR A disorder characterized by involvement of the sclera of the eye. NCI:CTCAE NCIT:C79717 Sclera disorder NCIT:C79717 An inflammatory process affecting a part of or the entire uvea. Causes include inflammatory agents (e.g., herpes simplex, herpes zoster, leptospirosis) and systemic diseases (e.g., inflammatory bowel disease, multiple sclerosis, systemic lupus erythematosus, ankylosing spondylitis). Patients present with pain and redness in the eye, light sensitivity, and blurred and decreased vision OR A disorder characterized by inflammation to the uvea of the eye. CCTO:000437 implies CCTO:000049 CCTO:000437 implies CCTO:001116 CCTO:000437(time_t t0) = EVENT_STATE(CCTO:000437, t0) NCI:CTCAE:10046851 NCIT:C26909 NCIT:C55901 UMLS:C0042164 UMLS:C1963266 Uveitis adverse event cancer_care_treatment_outcome CCTO:000437 Uveitis CCTO:000437 An inflammatory process affecting a part of or the entire uvea. Causes include inflammatory agents (e.g., herpes simplex, herpes zoster, leptospirosis) and systemic diseases (e.g., inflammatory bowel disease, multiple sclerosis, systemic lupus erythematosus, ankylosing spondylitis). Patients present with pain and redness in the eye, light sensitivity, and blurred and decreased vision OR A disorder characterized by inflammation to the uvea of the eye. NCI:CTCAE NCIT:C26909 Uveitis adverse event NCIT:C55901 Blood extravasation in the vitreous humor. Causes include neovascularization, retinal tear, retinal detachment, and rupture of a blood vessel aneurysm in the eye OR A disorder characterized by blood extravasation into the vitreous humor. CCTO:000438 implies CCTO:000049 CCTO:000438 implies CCTO:001116 CCTO:000438(time_t t0) = EVENT_STATE(CCTO:000438, t0) NCI:CTCAE:10047656 NCIT:C50469 NCIT:C55921 UMLS:C0042909 UMLS:C1963280 Blood in vitreous fluid Fluid, blood in vitreous Vitreous fluid, blood in Vitreous hemorrhage adverse event cancer_care_treatment_outcome CCTO:000438 Vitreous hemorrhage CCTO:000438 Blood extravasation in the vitreous humor. Causes include neovascularization, retinal tear, retinal detachment, and rupture of a blood vessel aneurysm in the eye OR A disorder characterized by blood extravasation into the vitreous humor. NCI:CTCAE NCIT:C50469 Blood in vitreous fluid NCIT:C50469 Fluid, blood in vitreous NCIT:C50469 Vitreous fluid, blood in NCIT:C50469 Vitreous hemorrhage adverse event NCIT:C55921 Tearing eyes; a condition caused either by tear overproduction or impaired drainage of the tear duct. Causes of tear overproduction include eye irritation (e.g., eye infection, foreign body in the eye), headache, pain reaction, allergies, sinusitis, and injury to the eye OR A disorder of excessive tearing in the eyes; it can be caused by overproduction of tears or impaired drainage of the tear duct. CCTO:000439 implies CCTO:000049 CCTO:000439 implies CCTO:001116 CCTO:000439(time_t t0) = EVENT_STATE(CCTO:000439, t0) NCI:CTCAE:10047848 NCIT:C78717 UMLS:C0152227 UMLS:C3257803 cancer_care_treatment_outcome CCTO:000439 Watering eyes CCTO:000439 Tearing eyes; a condition caused either by tear overproduction or impaired drainage of the tear duct. Causes of tear overproduction include eye irritation (e.g., eye infection, foreign body in the eye), headache, pain reaction, allergies, sinusitis, and injury to the eye OR A disorder of excessive tearing in the eyes; it can be caused by overproduction of tears or impaired drainage of the tear duct. NCI:CTCAE NCIT:C78717 A disorder characterized by swelling of the abdomen OR Swelling of the abdomen resulting from excessive food intake, malnutrition, liver disease, primary abdominal tumors, and tumors metastatic to the abdominal cavity. CCTO:000440 implies CCTO:000049 CCTO:000440 implies CCTO:001108 CCTO:000440(time_t t0) = EVENT_STATE(CCTO:000440, t0) NCI:CTCAE:10000060 NCIT:C78161 UMLS:C0000731 UMLS:C1291077 Abdominal bloating Abdominal distention cancer_care_treatment_outcome CCTO:000440 Abdominal distension CCTO:000440 A disorder characterized by swelling of the abdomen OR Swelling of the abdomen resulting from excessive food intake, malnutrition, liver disease, primary abdominal tumors, and tumors metastatic to the abdominal cavity. NCI:CTCAE NCIT:C78161 Abdominal bloating NCIT:C78161 Abdominal distention NCIT:C78161 A disorder characterized by a sensation of marked discomfort in the abdominal region OR Painful sensation in the abdominal region. CCTO:000441 implies CCTO:000107 CCTO:000441 implies CCTO:001108 CCTO:000441(time_t t0) = EVENT_STATE(CCTO:000441, t0) NCI:CTCAE:10000081 NCIT:C26682 UMLS:C0000737 Pain, abdominal cancer_care_treatment_outcome CCTO:000441 Abdominal pain CCTO:000441 A disorder characterized by a sensation of marked discomfort in the abdominal region OR Painful sensation in the abdominal region. NCI:CTCAE NCIT:C26682 Pain, abdominal NCIT:C26682 A disorder characterized by an abnormal communication between the opening in the anal canal to the perianal skin OR A pathologic tract that connects an opening in the anal canal to the perianal skin. In the vast majority of cases there is a history of perianal abscess. CCTO:000442 implies CCTO:000049 CCTO:000442 implies CCTO:001108 CCTO:000442(time_t t0) = EVENT_STATE(CCTO:000442, t0) NCI:CTCAE:10002156 NCIT:C60785 UMLS:C0149889 UMLS:C0205929 Anorectal fistula cancer_care_treatment_outcome CCTO:000442 Anal fistula CCTO:000442 A disorder characterized by an abnormal communication between the opening in the anal canal to the perianal skin OR A pathologic tract that connects an opening in the anal canal to the perianal skin. In the vast majority of cases there is a history of perianal abscess. NCI:CTCAE NCIT:C60785 Anorectal fistula NCIT:C60785 A disorder characterized by bleeding from the anal region OR Bleeding originating from the anal area. CCTO:000443 implies CCTO:000049 CCTO:000443 implies CCTO:001108 CCTO:000443(time_t t0) = EVENT_STATE(CCTO:000443, t0) NCI:CTCAE:10055226 NCIT:C78168 UMLS:C0426747 cancer_care_treatment_outcome CCTO:000443 Anal hemorrhage CCTO:000443 A disorder characterized by bleeding from the anal region OR Bleeding originating from the anal area. NCI:CTCAE NCIT:C78168 An inflammatory process affecting the mucous membrane of the anus OR A disorder characterized by inflammation of the mucous membrane of the anus. CCTO:000444 implies CCTO:000049 CCTO:000444 implies CCTO:001108 CCTO:000444(time_t t0) = EVENT_STATE(CCTO:000444, t0) NCI:CTCAE:10065721 NCIT:C78170 UMLS:C1699653 cancer_care_treatment_outcome CCTO:000444 Anal mucositis CCTO:000444 An inflammatory process affecting the mucous membrane of the anus OR A disorder characterized by inflammation of the mucous membrane of the anus. NCI:CTCAE NCIT:C78170 A disorder characterized by a necrotic process occurring in the anal region OR A necrotic process involving the area of the anus. CCTO:000445 implies CCTO:000049 CCTO:000445 implies CCTO:001108 CCTO:000445(time_t t0) = EVENT_STATE(CCTO:000445, t0) NCI:CTCAE:10065722 NCIT:C78171 UMLS:C1697981 Anal necrotic lesion cancer_care_treatment_outcome CCTO:000445 Anal necrosis CCTO:000445 A disorder characterized by a necrotic process occurring in the anal region OR A necrotic process involving the area of the anus. NCI:CTCAE NCIT:C78171 Anal necrotic lesion NCIT:C78171 A disorder characterized by a sensation of marked discomfort in the anal region OR Painful sensation in the anal region. CCTO:000446 implies CCTO:000107 CCTO:000446 implies CCTO:001108 CCTO:000446(time_t t0) = EVENT_STATE(CCTO:000446, t0) NCI:CTCAE:10002167 NCIT:C78172 UMLS:C0238637 cancer_care_treatment_outcome CCTO:000446 Anal pain CCTO:000446 A disorder characterized by a sensation of marked discomfort in the anal region OR Painful sensation in the anal region. NCI:CTCAE NCIT:C78172 A disorder characterized by a narrowing of the lumen of the anal canal OR Narrowing of the anal canal. CCTO:000447 implies CCTO:000049 CCTO:000447 implies CCTO:001108 CCTO:000447(time_t t0) = EVENT_STATE(CCTO:000447, t0) NCI:CTCAE:10002176 NCIT:C78173 UMLS:C0262374 cancer_care_treatment_outcome CCTO:000447 Anal stenosis CCTO:000447 A disorder characterized by a narrowing of the lumen of the anal canal OR Narrowing of the anal canal. NCI:CTCAE NCIT:C78173 A painful tear in the lining of the anal canal, often accompanied by bleeding on defecation. It is usually the result of a traumatic bowel movement or anal sexual penetration OR A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the anal canal. CCTO:000448 implies CCTO:000049 CCTO:000448 implies CCTO:001108 CCTO:000448(time_t t0) = EVENT_STATE(CCTO:000448, t0) NCI:CTCAE:10002180 NCIT:C79536 UMLS:C0016167 cancer_care_treatment_outcome CCTO:000448 Anal ulcer CCTO:000448 A painful tear in the lining of the anal canal, often accompanied by bleeding on defecation. It is usually the result of a traumatic bowel movement or anal sexual penetration OR A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the anal canal. NCI:CTCAE NCIT:C79536 A disorder characterized by accumulation of serous or hemorrhagic fluid in the peritoneal cavity OR The accumulation of fluid in the peritoneal cavity, which may be serous, hemorrhagic, or the result of tumor metastasis to the peritoneum. CCTO:000449 implies CCTO:000049 CCTO:000449 implies CCTO:001108 CCTO:000449(time_t t0) = EVENT_STATE(CCTO:000449, t0) NCI:CTCAE:10003445 NCIT:C2885 UMLS:C0003962 INCREASING ABDOMINAL DISTENTION OR ASCITES cancer_care_treatment_outcome CCTO:000449 Ascites CCTO:000449 A disorder characterized by accumulation of serous or hemorrhagic fluid in the peritoneal cavity OR The accumulation of fluid in the peritoneal cavity, which may be serous, hemorrhagic, or the result of tumor metastasis to the peritoneum. NCI:CTCAE NCIT:C2885 INCREASING ABDOMINAL DISTENTION OR ASCITES NCIT:C2885 Distention of the abdomen associated with a feeling of fullness OR A disorder characterized by subject-reported feeling of uncomfortable fullness of the abdomen. CCTO:000450 implies CCTO:000049 CCTO:000450 implies CCTO:001108 CCTO:000450(time_t t0) = EVENT_STATE(CCTO:000450, t0) NCI:CTCAE:10005265 NCIT:C78213 UMLS:C1291077 cancer_care_treatment_outcome CCTO:000450 Bloating CCTO:000450 Distention of the abdomen associated with a feeling of fullness OR A disorder characterized by subject-reported feeling of uncomfortable fullness of the abdomen. NCI:CTCAE NCIT:C78213 Bleeding originating in the cecum OR A disorder characterized by bleeding from the cecum. CCTO:000451 implies CCTO:000049 CCTO:000451 implies CCTO:001108 CCTO:000451(time_t t0) = EVENT_STATE(CCTO:000451, t0) NCI:CTCAE:10065747 NCIT:C78234 UMLS:C1699142 cancer_care_treatment_outcome CCTO:000451 Cecal hemorrhage CCTO:000451 Bleeding originating in the cecum OR A disorder characterized by bleeding from the cecum. NCI:CTCAE NCIT:C78234 A disorder characterized by inflammation of the lip OR An inflammatory process affecting the lip. CCTO:000452 implies CCTO:000049 CCTO:000452 implies CCTO:001108 CCTO:000452(time_t t0) = EVENT_STATE(CCTO:000452, t0) NCI:CTCAE:10008417 NCIT:C57901 NCIT:C79545 UMLS:C0007971 UMLS:C1962954 Cheilitis adverse event cancer_care_treatment_outcome CCTO:000452 Cheilitis CCTO:000452 A disorder characterized by inflammation of the lip OR An inflammatory process affecting the lip. NCI:CTCAE NCIT:C79545 Cheilitis adverse event NCIT:C57901 A disorder characterized by inflammation of the colon OR Inflammation of the colon. CCTO:000453 implies CCTO:000049 CCTO:000453 implies CCTO:001108 CCTO:000453(time_t t0) = EVENT_STATE(CCTO:000453, t0) NCI:CTCAE:10009887 NCIT:C26723 NCIT:C57134 UMLS:C0009319 UMLS:C1963084 Colitis adverse event cancer_care_treatment_outcome CCTO:000453 Colitis CCTO:000453 A disorder characterized by inflammation of the colon OR Inflammation of the colon. NCI:CTCAE NCIT:C26723 Colitis adverse event NCIT:C57134 An abnormal communication between the large intestine and another organ or cavity OR A disorder characterized by an abnormal communication between the large intestine and another organ or anatomic site. CCTO:000454 implies CCTO:000049 CCTO:000454 implies CCTO:001108 CCTO:000454(time_t t0) = EVENT_STATE(CCTO:000454, t0) NCI:CTCAE:10009995 NCIT:C78239 UMLS:C0341364 UMLS:C0341365 Large bowel fistula cancer_care_treatment_outcome CCTO:000454 Colonic fistula CCTO:000454 An abnormal communication between the large intestine and another organ or cavity OR A disorder characterized by an abnormal communication between the large intestine and another organ or anatomic site. NCI:CTCAE NCIT:C78239 Large bowel fistula NCIT:C78239 A disorder characterized by bleeding from the colon OR Bleeding originating from the colon. CCTO:000455 implies CCTO:000049 CCTO:000455 implies CCTO:001108 CCTO:000455(time_t t0) = EVENT_STATE(CCTO:000455, t0) NCI:CTCAE:10009998 NCIT:C78240 UMLS:C0151694 cancer_care_treatment_outcome CCTO:000455 Colonic hemorrhage CCTO:000455 A disorder characterized by bleeding from the colon OR Bleeding originating from the colon. NCI:CTCAE NCIT:C78240 A disorder characterized by blockage of the normal flow of the intestinal contents in the colon OR Blockage of the normal flow of the intestinal contents in the colon. CCTO:000456 implies CCTO:000049 CCTO:000456 implies CCTO:001108 CCTO:000456(time_t t0) = EVENT_STATE(CCTO:000456, t0) NCI:CTCAE:10010000 NCIT:C78241 UMLS:C0235328 cancer_care_treatment_outcome CCTO:000456 Colonic obstruction CCTO:000456 A disorder characterized by blockage of the normal flow of the intestinal contents in the colon OR Blockage of the normal flow of the intestinal contents in the colon. NCI:CTCAE NCIT:C78241 A disorder characterized by a rupture in the colonic wall OR A rupture in the colonic wall due to traumatic or pathologic processes. CCTO:000457 implies CCTO:000049 CCTO:000457 implies CCTO:001108 CCTO:000457(time_t t0) = EVENT_STATE(CCTO:000457, t0) NCI:CTCAE:10010001 NCIT:C78242 UMLS:C0347646 cancer_care_treatment_outcome CCTO:000457 Colonic perforation CCTO:000457 A disorder characterized by a rupture in the colonic wall OR A rupture in the colonic wall due to traumatic or pathologic processes. NCI:CTCAE NCIT:C78242 Narrowing of the lumen of colon OR A disorder characterized by a narrowing of the lumen of the colon. CCTO:000458 implies CCTO:000049 CCTO:000458 implies CCTO:001108 CCTO:000458(time_t t0) = EVENT_STATE(CCTO:000458, t0) NCI:CTCAE:10010004 NCIT:C78243 UMLS:C0267466 cancer_care_treatment_outcome CCTO:000458 Colonic stenosis CCTO:000458 Narrowing of the lumen of colon OR A disorder characterized by a narrowing of the lumen of the colon. NCI:CTCAE NCIT:C78243 A circumscribed inflammatory and necrotic erosive lesion in the mucosa surface of the colon OR A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the colon. CCTO:000459 implies CCTO:000049 CCTO:000459 implies CCTO:001108 CCTO:000459(time_t t0) = EVENT_STATE(CCTO:000459, t0) NCI:CTCAE:10010006 NCIT:C78244 UMLS:C0267491 cancer_care_treatment_outcome CCTO:000459 Colonic ulcer CCTO:000459 A circumscribed inflammatory and necrotic erosive lesion in the mucosa surface of the colon OR A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the colon. NCI:CTCAE NCIT:C78244 A disorder characterized by irregular and infrequent or difficult evacuation of the bowels OR A question about whether an individual is or has been constipated OR A question about how often an individual has or had constipation OR A question about the usual severity of an individual's constipation OR A question about an individual's distress from their constipation OR Irregular and infrequent or difficult evacuation of the bowels. CCTO:000460 implies CCTO:000049 CCTO:000460 implies CCTO:001108 CCTO:000460(time_t t0) = EVENT_STATE(CCTO:000460, t0) NCI:CTCAE:10010774 NCIT:C104299 NCIT:C125294 NCIT:C125326 NCIT:C125358 NCIT:C37930 NCIT:C57141 UMLS:C0009806 UMLS:C1963087 UMLS:C3641755 Constipation adverse event Constipation frequency Frequency of Constipation Have been constipated Have constipation Have you been constipated How much distress constipation How often constipation Usual severity constipation cancer_care_treatment_outcome CCTO:000460 Constipation CCTO:000460 A disorder characterized by irregular and infrequent or difficult evacuation of the bowels OR A question about whether an individual is or has been constipated OR A question about how often an individual has or had constipation OR A question about the usual severity of an individual's constipation OR A question about an individual's distress from their constipation OR Irregular and infrequent or difficult evacuation of the bowels. NCI:CTCAE NCIT:C104299 NCIT:C125294 NCIT:C125326 NCIT:C125358 NCIT:C37930 Constipation adverse event NCIT:C57141 Constipation frequency NCIT:C125294 Frequency of Constipation NCIT:C125294 Have been constipated NCIT:C104299 Have constipation NCIT:C104299 Have you been constipated NCIT:C104299 How much distress constipation NCIT:C125358 How often constipation NCIT:C125294 Usual severity constipation NCIT:C125326 A disorder characterized by the decay of a tooth, in which it becomes softened, discolored and/or porous OR The decay of a tooth, in which it becomes softened, discolored, and/or porous. CCTO:000461 implies CCTO:000049 CCTO:000461 implies CCTO:001108 CCTO:000461(time_t t0) = EVENT_STATE(CCTO:000461, t0) NCI:CTCAE:10012318 NCIT:C52593 UMLS:C0011334 Caries Cavities Tooth decay cancer_care_treatment_outcome CCTO:000461 Dental caries CCTO:000461 A disorder characterized by the decay of a tooth, in which it becomes softened, discolored and/or porous OR The decay of a tooth, in which it becomes softened, discolored, and/or porous. NCI:CTCAE NCIT:C52593 Caries NCIT:C52593 Cavities NCIT:C52593 Tooth decay NCIT:C52593 Watery bowel movements OR A question about whether an individual has or had diarrhea OR A disorder characterized by frequent and watery bowel movements OR A question about the usual severity of an individual's diarrhea OR A question about an individual's distress from their diarrhea OR A question about how often an individual has or had diarrhea. CCTO:000462 implies CCTO:000049 CCTO:000462 implies CCTO:001108 CCTO:000462(time_t t0) = EVENT_STATE(CCTO:000462, t0) NCI:CTCAE:10012727 NCIT:C104300 NCIT:C125280 NCIT:C125312 NCIT:C125344 NCIT:C2987 NCIT:C57788 UMLS:C0011991 UMLS:C0232708 UMLS:C0848342 UMLS:C1963091 UMLS:C2129214 UMLS:C3641756 Diarrhea adverse event Diarrhea frequency Frequency of Diarrhea Frequent stools Have diarrhea Have you had diarrhea How much distress diarrhea How often diarrhea I have diarrhea Loose stools Usual severity diarrhea cancer_care_treatment_outcome CCTO:000462 Diarrhea CCTO:000462 Watery bowel movements OR A question about whether an individual has or had diarrhea OR A disorder characterized by frequent and watery bowel movements OR A question about the usual severity of an individual's diarrhea OR A question about an individual's distress from their diarrhea OR A question about how often an individual has or had diarrhea. NCI:CTCAE NCIT:C104300 NCIT:C125280 NCIT:C125312 NCIT:C125344 NCIT:C2987 Diarrhea adverse event NCIT:C57788 Diarrhea frequency NCIT:C125280 Frequency of Diarrhea NCIT:C125280 Frequent stools NCIT:C2987 Have diarrhea NCIT:C104300 Have you had diarrhea NCIT:C104300 How much distress diarrhea NCIT:C125344 How often diarrhea NCIT:C125280 I have diarrhea NCIT:C104300 Loose stools NCIT:C2987 Usual severity diarrhea NCIT:C125312 A question about the usual severity of an individual's dry mouth OR A disorder characterized by reduced salivary flow in the oral cavity OR A question about how often an individual has or had dry mouth OR A question about whether an individual has or had a dry mouth OR A question about an individual's distress from their dry mouth OR Dryness of the oral mucosa secondary to a decrease in saliva production, or a change in saliva composition. CCTO:000463 implies CCTO:000049 CCTO:000463 implies CCTO:001108 CCTO:000463(time_t t0) = EVENT_STATE(CCTO:000463, t0) NCI:CTCAE:10013781 NCIT:C104937 NCIT:C125270 NCIT:C125303 NCIT:C125335 NCIT:C26917 UMLS:C0043352 UMLS:C3641895 Did you have a dry mouth Do you often experience ''dry mouth'' Dry mouth frequency Experience dry mouth Frequency of Dry Mouth Have dry mouth How much distress dry mouth How often dry mouth My mouth is dry Usual severity dry mouth Xerostomia cancer_care_treatment_outcome CCTO:000463 Dry mouth CCTO:000463 A question about the usual severity of an individual's dry mouth OR A disorder characterized by reduced salivary flow in the oral cavity OR A question about how often an individual has or had dry mouth OR A question about whether an individual has or had a dry mouth OR A question about an individual's distress from their dry mouth OR Dryness of the oral mucosa secondary to a decrease in saliva production, or a change in saliva composition. NCI:CTCAE NCIT:C104937 NCIT:C125270 NCIT:C125303 NCIT:C125335 NCIT:C26917 Did you have a dry mouth NCIT:C104937 Do you often experience ''dry mouth'' NCIT:C104937 Dry mouth frequency NCIT:C125270 Experience dry mouth NCIT:C104937 Frequency of Dry Mouth NCIT:C125270 Have dry mouth NCIT:C104937 How much distress dry mouth NCIT:C125335 How often dry mouth NCIT:C125270 My mouth is dry NCIT:C104937 Usual severity dry mouth NCIT:C125303 Xerostomia NCIT:C26917 A disorder characterized by an abnormal communication between the duodenum and another organ or anatomic site OR An abnormal communication between the duodenum and another organ or cavity. CCTO:000464 implies CCTO:000049 CCTO:000464 implies CCTO:001108 CCTO:000464(time_t t0) = EVENT_STATE(CCTO:000464, t0) NCI:CTCAE:10013828 NCIT:C78256 UMLS:C0267358 cancer_care_treatment_outcome CCTO:000464 Duodenal fistula CCTO:000464 A disorder characterized by an abnormal communication between the duodenum and another organ or anatomic site OR An abnormal communication between the duodenum and another organ or cavity. NCI:CTCAE NCIT:C78256 A disorder characterized by bleeding from the duodenum OR Bleeding originating from the duodenum. CCTO:000465 implies CCTO:000049 CCTO:000465 implies CCTO:001108 CCTO:000465(time_t t0) = EVENT_STATE(CCTO:000465, t0) NCI:CTCAE:10055242 NCIT:C78257 UMLS:C0521595 cancer_care_treatment_outcome CCTO:000465 Duodenal hemorrhage CCTO:000465 A disorder characterized by bleeding from the duodenum OR Bleeding originating from the duodenum. NCI:CTCAE NCIT:C78257 A disorder characterized by blockage of the normal flow of stomach contents through the duodenum OR Blockage of the normal flow of stomach contents through the duodenum. CCTO:000466 implies CCTO:000049 CCTO:000466 implies CCTO:001108 CCTO:000466(time_t t0) = EVENT_STATE(CCTO:000466, t0) NCI:CTCAE:10013830 NCIT:C79548 UMLS:C0013292 cancer_care_treatment_outcome CCTO:000466 Duodenal obstruction CCTO:000466 A disorder characterized by blockage of the normal flow of stomach contents through the duodenum OR Blockage of the normal flow of stomach contents through the duodenum. NCI:CTCAE NCIT:C79548 A rupture in the duodenal wall due to traumatic or pathologic processes OR A disorder characterized by a rupture in the duodenal wall. CCTO:000467 implies CCTO:000049 CCTO:000467 implies CCTO:001108 CCTO:000467(time_t t0) = EVENT_STATE(CCTO:000467, t0) NCI:CTCAE:10013832 NCIT:C78259 UMLS:C0267356 cancer_care_treatment_outcome CCTO:000467 Duodenal perforation CCTO:000467 A rupture in the duodenal wall due to traumatic or pathologic processes OR A disorder characterized by a rupture in the duodenal wall. NCI:CTCAE NCIT:C78259 A disorder characterized by a narrowing of the lumen of the duodenum OR Narrowing of the lumen of the duodenum. CCTO:000468 implies CCTO:000049 CCTO:000468 implies CCTO:001108 CCTO:000468(time_t t0) = EVENT_STATE(CCTO:000468, t0) NCI:CTCAE:10050094 NCIT:C78260 UMLS:C0238093 cancer_care_treatment_outcome CCTO:000468 Duodenal stenosis CCTO:000468 A disorder characterized by a narrowing of the lumen of the duodenum OR Narrowing of the lumen of the duodenum. NCI:CTCAE NCIT:C78260 A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the duodenal wall OR An ulcer in the duodenal wall. CCTO:000469 implies CCTO:000049 CCTO:000469 implies CCTO:001108 CCTO:000469(time_t t0) = EVENT_STATE(CCTO:000469, t0) NCI:CTCAE:10013836 NCIT:C26755 UMLS:C0013295 cancer_care_treatment_outcome CCTO:000469 Duodenal ulcer CCTO:000469 A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the duodenal wall OR An ulcer in the duodenal wall. NCI:CTCAE NCIT:C26755 An uncomfortable, often painful feeling in the stomach, resulting from impaired digestion. Symptoms include burning stomach pain, bloating, heartburn, nausea, and vomiting. Causes include gastritis, gastric ulcer, gastroesophageal reflux disease, pancreatic disease, and gallbladder disease OR A disorder characterized by an uncomfortable, often painful feeling in the stomach, resulting from impaired digestion. Symptoms include burning stomach, bloating, heartburn, nausea and vomiting. CCTO:000470 implies CCTO:000049 CCTO:000470 implies CCTO:001108 CCTO:000470(time_t t0) = EVENT_STATE(CCTO:000470, t0) NCI:CTCAE:10013946 NCIT:C26756 UMLS:C0013395 Indigestion cancer_care_treatment_outcome CCTO:000470 Dyspepsia CCTO:000470 An uncomfortable, often painful feeling in the stomach, resulting from impaired digestion. Symptoms include burning stomach pain, bloating, heartburn, nausea, and vomiting. Causes include gastritis, gastric ulcer, gastroesophageal reflux disease, pancreatic disease, and gallbladder disease OR A disorder characterized by an uncomfortable, often painful feeling in the stomach, resulting from impaired digestion. Symptoms include burning stomach, bloating, heartburn, nausea and vomiting. NCI:CTCAE NCIT:C26756 Indigestion NCIT:C26756 A symptom referring to difficulty in swallowing. It may be observed in patients with stroke, motor neuron disorders, cancer of the throat or mouth, head and neck injuries, Parkinson disease, and multiple sclerosis OR A disorder characterized by difficulty in swallowing. CCTO:000471 implies CCTO:000049 CCTO:000471 implies CCTO:001108 CCTO:000471(time_t t0) = EVENT_STATE(CCTO:000471, t0) NCI:CTCAE:10013950 NCIT:C2980 UMLS:C0011168 Difficulty swallowing cancer_care_treatment_outcome CCTO:000471 Dysphagia CCTO:000471 A symptom referring to difficulty in swallowing. It may be observed in patients with stroke, motor neuron disorders, cancer of the throat or mouth, head and neck injuries, Parkinson disease, and multiple sclerosis OR A disorder characterized by difficulty in swallowing. NCI:CTCAE NCIT:C2980 Difficulty swallowing NCIT:C2980 An inflammatory process affecting the small intestine and colon. Causes include viruses, bacteria, radiation, and antibiotics use OR A disorder characterized by inflammation of the small and large intestines. CCTO:000472 implies CCTO:000049 CCTO:000472 implies CCTO:001108 CCTO:000472(time_t t0) = EVENT_STATE(CCTO:000472, t0) NCI:CTCAE:10014893 NCIT:C79573 UMLS:C0014356 cancer_care_treatment_outcome CCTO:000472 Enterocolitis CCTO:000472 An inflammatory process affecting the small intestine and colon. Causes include viruses, bacteria, radiation, and antibiotics use OR A disorder characterized by inflammation of the small and large intestines. NCI:CTCAE NCIT:C79573 An abnormal communication between the urinary bladder and the intestine OR A disorder characterized by an abnormal communication between the urinary bladder and the intestine. CCTO:000473 implies CCTO:000049 CCTO:000473 implies CCTO:001108 CCTO:000473(time_t t0) = EVENT_STATE(CCTO:000473, t0) NCI:CTCAE:10062570 NCIT:C78266 UMLS:C0156272 cancer_care_treatment_outcome CCTO:000473 Enterovesical fistula CCTO:000473 An abnormal communication between the urinary bladder and the intestine OR A disorder characterized by an abnormal communication between the urinary bladder and the intestine. NCI:CTCAE NCIT:C78266 An abnormal communication between the esophagus and another organ or anatomic site OR A disorder characterized by an abnormal communication between the esophagus and another organ or anatomic site. CCTO:000474 implies CCTO:000049 CCTO:000474 implies CCTO:001108 CCTO:000474(time_t t0) = EVENT_STATE(CCTO:000474, t0) NCI:CTCAE:10065851 NCIT:C79574 UMLS:C0014856 cancer_care_treatment_outcome CCTO:000474 Esophageal fistula CCTO:000474 An abnormal communication between the esophagus and another organ or anatomic site OR A disorder characterized by an abnormal communication between the esophagus and another organ or anatomic site. NCI:CTCAE NCIT:C79574 A disorder characterized by bleeding from the esophagus OR Bleeding originating from the esophagus. CCTO:000475 implies CCTO:000049 CCTO:000475 implies CCTO:001108 CCTO:000475(time_t t0) = EVENT_STATE(CCTO:000475, t0) NCI:CTCAE:10015384 NCIT:C78271 UMLS:C0239293 cancer_care_treatment_outcome CCTO:000475 Esophageal hemorrhage CCTO:000475 A disorder characterized by bleeding from the esophagus OR Bleeding originating from the esophagus. NCI:CTCAE NCIT:C78271 A disorder characterized by a necrotic process occurring in the esophageal wall OR A necrotic process involving the esophageal wall. CCTO:000476 implies CCTO:000049 CCTO:000476 implies CCTO:001108 CCTO:000476(time_t t0) = EVENT_STATE(CCTO:000476, t0) NCI:CTCAE:10065727 NCIT:C78278 UMLS:C1697884 Esophageal necrotic lesion cancer_care_treatment_outcome CCTO:000476 Esophageal necrosis CCTO:000476 A disorder characterized by a necrotic process occurring in the esophageal wall OR A necrotic process involving the esophageal wall. NCI:CTCAE NCIT:C78278 Esophageal necrotic lesion NCIT:C78278 A disorder characterized by blockage of the normal flow of the contents in the esophagus OR Blockage of the normal flow of the contents in the esophagus. CCTO:000477 implies CCTO:000049 CCTO:000477 implies CCTO:001108 CCTO:000477(time_t t0) = EVENT_STATE(CCTO:000477, t0) NCI:CTCAE:10015387 NCIT:C78279 UMLS:C0239296 cancer_care_treatment_outcome CCTO:000477 Esophageal obstruction CCTO:000477 A disorder characterized by blockage of the normal flow of the contents in the esophagus OR Blockage of the normal flow of the contents in the esophagus. NCI:CTCAE NCIT:C78279 Painful sensation in the esophageal region OR A disorder characterized by a sensation of marked discomfort in the esophageal region. CCTO:000478 implies CCTO:000107 CCTO:000478 implies CCTO:001108 CCTO:000478(time_t t0) = EVENT_STATE(CCTO:000478, t0) NCI:CTCAE:10015388 NCIT:C78280 UMLS:C0221727 cancer_care_treatment_outcome CCTO:000478 Esophageal pain CCTO:000478 Painful sensation in the esophageal region OR A disorder characterized by a sensation of marked discomfort in the esophageal region. NCI:CTCAE NCIT:C78280 A disorder characterized by a rupture in the wall of the esophagus OR The presence of a hole or other type of opening in the esophageal wall through which the contents of the esophagus can pass into the mediastinum. The most common cause of esophageal perforation is injury during a medical procedure such as esophagoscopy or placement of a naso-gastric tube; and pathologic process such as neoplasm or gastric reflux with ulceration. Less common causes include injuries from penetrating or blunt trauma or injury to the esophagus during an operation on another organ, mechanical problem such as violent retching or vomiting; ingestion of a foreign body or caustic agents. The condition often results in infection of the mediastinum and mediastinitis. CCTO:000479 implies CCTO:000049 CCTO:000479 implies CCTO:001108 CCTO:000479(time_t t0) = EVENT_STATE(CCTO:000479, t0) NCI:CTCAE:10055472 NCIT:C50693 UMLS:C0014860 Esophagus, perforation of Perforation of Esophagus Perforation of esophagus cancer_care_treatment_outcome CCTO:000479 Esophageal perforation CCTO:000479 A disorder characterized by a rupture in the wall of the esophagus OR The presence of a hole or other type of opening in the esophageal wall through which the contents of the esophagus can pass into the mediastinum. The most common cause of esophageal perforation is injury during a medical procedure such as esophagoscopy or placement of a naso-gastric tube; and pathologic process such as neoplasm or gastric reflux with ulceration. Less common causes include injuries from penetrating or blunt trauma or injury to the esophagus during an operation on another organ, mechanical problem such as violent retching or vomiting; ingestion of a foreign body or caustic agents. The condition often results in infection of the mediastinum and mediastinitis. NCI:CTCAE NCIT:C50693 Esophagus, perforation of NCIT:C50693 Perforation of Esophagus NCIT:C50693 Perforation of esophagus NCIT:C50693 A disorder characterized by a narrowing of the lumen of the esophagus OR Narrowing of the lumen of the esophagus. CCTO:000480 implies CCTO:000049 CCTO:000480 implies CCTO:001108 CCTO:000480(time_t t0) = EVENT_STATE(CCTO:000480, t0) NCI:CTCAE:10015448 NCIT:C34595 UMLS:C0014866 Esophageal stricture cancer_care_treatment_outcome CCTO:000480 Esophageal stenosis CCTO:000480 A disorder characterized by a narrowing of the lumen of the esophagus OR Narrowing of the lumen of the esophagus. NCI:CTCAE NCIT:C34595 Esophageal stricture NCIT:C34595 A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the esophageal wall OR An ulcerated lesion in the esophageal wall. CCTO:000481 implies CCTO:000049 CCTO:000481 implies CCTO:001108 CCTO:000481(time_t t0) = EVENT_STATE(CCTO:000481, t0) NCI:CTCAE:10015451 NCIT:C26950 UMLS:C0151970 cancer_care_treatment_outcome CCTO:000481 Esophageal ulcer CCTO:000481 A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the esophageal wall OR An ulcerated lesion in the esophageal wall. NCI:CTCAE NCIT:C26950 Bleeding from esophageal varices OR A disorder characterized by bleeding from esophageal varices. CCTO:000482 implies CCTO:000049 CCTO:000482 implies CCTO:001108 CCTO:000482(time_t t0) = EVENT_STATE(CCTO:000482, t0) NCI:CTCAE:10015453 NCIT:C78282 UMLS:C0155789 cancer_care_treatment_outcome CCTO:000482 Esophageal varices hemorrhage CCTO:000482 Bleeding from esophageal varices OR A disorder characterized by bleeding from esophageal varices. NCI:CTCAE NCIT:C78282 A disorder characterized by inflammation of the esophageal wall OR An acute or chronic inflammatory process affecting the esophageal wall. CCTO:000483 implies CCTO:000049 CCTO:000483 implies CCTO:001108 CCTO:000483(time_t t0) = EVENT_STATE(CCTO:000483, t0) NCI:CTCAE:10015461 NCIT:C57797 NCIT:C9224 UMLS:C0014868 UMLS:C1963106 Esophagitis adverse event cancer_care_treatment_outcome CCTO:000483 Esophagitis CCTO:000483 A disorder characterized by inflammation of the esophageal wall OR An acute or chronic inflammatory process affecting the esophageal wall. NCI:CTCAE NCIT:C9224 Esophagitis adverse event NCIT:C57797 A disorder characterized by inability to control the escape of stool from the rectum OR Involuntary passage of stool from the rectum. CCTO:000484 implies CCTO:000049 CCTO:000484 implies CCTO:001108 CCTO:000484(time_t t0) = EVENT_STATE(CCTO:000484, t0) NCI:CTCAE:10016296 NCIT:C78498 UMLS:C0015732 cancer_care_treatment_outcome CCTO:000484 Fecal incontinence CCTO:000484 A disorder characterized by inability to control the escape of stool from the rectum OR Involuntary passage of stool from the rectum. NCI:CTCAE NCIT:C78498 A disorder characterized by a state of excessive gas in the alimentary canal OR A state of excessive gas in the alimentary canal. CCTO:000485 implies CCTO:000049 CCTO:000485 implies CCTO:001108 CCTO:000485(time_t t0) = EVENT_STATE(CCTO:000485, t0) NCI:CTCAE:10016766 NCIT:C37954 NCIT:C57807 UMLS:C0016204 UMLS:C1962956 Flatulence adverse event cancer_care_treatment_outcome CCTO:000485 Flatulence CCTO:000485 A disorder characterized by a state of excessive gas in the alimentary canal OR A state of excessive gas in the alimentary canal. NCI:CTCAE NCIT:C37954 Flatulence adverse event NCIT:C57807 An abnormal communication between the stomach and another organ or anatomic site OR A disorder characterized by an abnormal communication between the stomach and another organ or anatomic site. CCTO:000486 implies CCTO:000049 CCTO:000486 implies CCTO:001108 CCTO:000486(time_t t0) = EVENT_STATE(CCTO:000486, t0) NCI:CTCAE:10065713 NCIT:C79595 UMLS:C0017128 cancer_care_treatment_outcome CCTO:000486 Gastric fistula CCTO:000486 An abnormal communication between the stomach and another organ or anatomic site OR A disorder characterized by an abnormal communication between the stomach and another organ or anatomic site. NCI:CTCAE NCIT:C79595 Bleeding from the gastric wall OR A disorder characterized by bleeding from the gastric wall. CCTO:000487 implies CCTO:000049 CCTO:000487 implies CCTO:001108 CCTO:000487(time_t t0) = EVENT_STATE(CCTO:000487, t0) NCI:CTCAE:10017789 NCIT:C54582 UMLS:C0235325 cancer_care_treatment_outcome CCTO:000487 Gastric hemorrhage CCTO:000487 Bleeding from the gastric wall OR A disorder characterized by bleeding from the gastric wall. NCI:CTCAE NCIT:C54582 A necrotic process affecting the gastric wall OR A disorder characterized by a necrotic process occurring in the gastric wall. CCTO:000488 implies CCTO:000049 CCTO:000488 implies CCTO:001108 CCTO:000488(time_t t0) = EVENT_STATE(CCTO:000488, t0) NCI:CTCAE:10051886 NCIT:C78314 UMLS:C0341221 Gastric necrotic lesion cancer_care_treatment_outcome CCTO:000488 Gastric necrosis CCTO:000488 A necrotic process affecting the gastric wall OR A disorder characterized by a necrotic process occurring in the gastric wall. NCI:CTCAE NCIT:C78314 Gastric necrotic lesion NCIT:C78314 A rupture in the gastric wall caused by traumatic or pathologic processes OR A disorder characterized by a rupture in the stomach wall. CCTO:000489 implies CCTO:000049 CCTO:000489 implies CCTO:001108 CCTO:000489(time_t t0) = EVENT_STATE(CCTO:000489, t0) NCI:CTCAE:10017815 NCIT:C78316 UMLS:C0235884 cancer_care_treatment_outcome CCTO:000489 Gastric perforation CCTO:000489 A rupture in the gastric wall caused by traumatic or pathologic processes OR A disorder characterized by a rupture in the stomach wall. NCI:CTCAE NCIT:C78316 Narrowing of the lumen of the stomach OR A disorder characterized by a narrowing of the lumen of the stomach. CCTO:000490 implies CCTO:000049 CCTO:000490 implies CCTO:001108 CCTO:000490(time_t t0) = EVENT_STATE(CCTO:000490, t0) NCI:CTCAE:10061970 NCIT:C78317 UMLS:C0585012 cancer_care_treatment_outcome CCTO:000490 Gastric stenosis CCTO:000490 Narrowing of the lumen of the stomach OR A disorder characterized by a narrowing of the lumen of the stomach. NCI:CTCAE NCIT:C78317 An ulcerated lesion in the mucosal surface of the stomach. It may progress to involve the deeper layers of the gastric wall OR A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the stomach. CCTO:000491 implies CCTO:000049 CCTO:000491 implies CCTO:001108 CCTO:000491(time_t t0) = EVENT_STATE(CCTO:000491, t0) NCI:CTCAE:10017822 NCIT:C3388 UMLS:C0038358 cancer_care_treatment_outcome CCTO:000491 Gastric ulcer CCTO:000491 An ulcerated lesion in the mucosal surface of the stomach. It may progress to involve the deeper layers of the gastric wall OR A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the stomach. NCI:CTCAE NCIT:C3388 A disorder characterized by inflammation of the stomach OR Inflammation of the stomach. CCTO:000492 implies CCTO:000049 CCTO:000492 implies CCTO:001108 CCTO:000492(time_t t0) = EVENT_STATE(CCTO:000492, t0) NCI:CTCAE:10017853 NCIT:C26780 UMLS:C0017152 cancer_care_treatment_outcome CCTO:000492 Gastritis CCTO:000492 A disorder characterized by inflammation of the stomach OR Inflammation of the stomach. NCI:CTCAE NCIT:C26780 A disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is chronic in nature and usually caused by incompetence of the lower esophageal sphincter, and may result in injury to the esophageal mucosal. Symptoms include heartburn and acid indigestion OR A chronic disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is usually caused by incompetence of the lower esophageal sphincter. Symptoms include heartburn and acid indigestion. It may cause injury to the esophageal mucosa. CCTO:000493 implies CCTO:000049 CCTO:000493 implies CCTO:001108 CCTO:000493(time_t t0) = EVENT_STATE(CCTO:000493, t0) NCI:CTCAE:10066874 NCIT:C26781 UMLS:C0017168 GERD cancer_care_treatment_outcome CCTO:000493 Gastroesophageal reflux disease CCTO:000493 A disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is chronic in nature and usually caused by incompetence of the lower esophageal sphincter, and may result in injury to the esophageal mucosal. Symptoms include heartburn and acid indigestion OR A chronic disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is usually caused by incompetence of the lower esophageal sphincter. Symptoms include heartburn and acid indigestion. It may cause injury to the esophageal mucosa. NCI:CTCAE NCIT:C26781 GERD NCIT:C26781 A disorder characterized by an abnormal communication between any part of the gastrointestinal system and another organ or anatomic site OR An abnormal communication between any part of the digestive system and another organ or cavity. CCTO:000494 implies CCTO:000049 CCTO:000494 implies CCTO:001108 CCTO:000494(time_t t0) = EVENT_STATE(CCTO:000494, t0) NCI:CTCAE:10017877 NCIT:C78319 UMLS:C0079238 UMLS:C0341212 Digestive system fistula cancer_care_treatment_outcome CCTO:000494 Gastrointestinal fistula CCTO:000494 A disorder characterized by an abnormal communication between any part of the gastrointestinal system and another organ or anatomic site OR An abnormal communication between any part of the digestive system and another organ or cavity. NCI:CTCAE NCIT:C78319 Digestive system fistula NCIT:C78319 A disorder characterized by a sensation of marked discomfort in the gastrointestinal region OR Painful sensation in the gastrointestinal region. CCTO:000495 implies CCTO:000107 CCTO:000495 implies CCTO:001108 CCTO:000495(time_t t0) = EVENT_STATE(CCTO:000495, t0) NCI:CTCAE:10017999 NCIT:C78320 UMLS:C0687713 cancer_care_treatment_outcome CCTO:000495 Gastrointestinal pain CCTO:000495 A disorder characterized by a sensation of marked discomfort in the gastrointestinal region OR Painful sensation in the gastrointestinal region. NCI:CTCAE NCIT:C78320 A disorder characterized by an incomplete paralysis of the muscles of the stomach wall resulting in delayed emptying of the gastric contents into the small intestine OR Paralysis of the muscles of the stomach wall resulting in delayed emptying of the gastric contents into the small intestine. CCTO:000496 implies CCTO:000049 CCTO:000496 implies CCTO:001108 CCTO:000496(time_t t0) = EVENT_STATE(CCTO:000496, t0) NCI:CTCAE:10018043 NCIT:C80512 UMLS:C0152020 cancer_care_treatment_outcome CCTO:000496 Gastroparesis CCTO:000496 A disorder characterized by an incomplete paralysis of the muscles of the stomach wall resulting in delayed emptying of the gastric contents into the small intestine OR Paralysis of the muscles of the stomach wall resulting in delayed emptying of the gastric contents into the small intestine. NCI:CTCAE NCIT:C80512 Painful sensation in the gingival region OR A disorder characterized by a sensation of marked discomfort in the gingival region. CCTO:000497 implies CCTO:000107 CCTO:000497 implies CCTO:001108 CCTO:000497(time_t t0) = EVENT_STATE(CCTO:000497, t0) NCI:CTCAE:10018286 NCIT:C78325 UMLS:C0239739 cancer_care_treatment_outcome CCTO:000497 Gingival pain CCTO:000497 Painful sensation in the gingival region OR A disorder characterized by a sensation of marked discomfort in the gingival region. NCI:CTCAE NCIT:C78325 Bleeding from the hemorrhoids OR A disorder characterized by bleeding from the hemorrhoids. CCTO:000498 implies CCTO:000049 CCTO:000498 implies CCTO:001108 CCTO:000498(time_t t0) = EVENT_STATE(CCTO:000498, t0) NCI:CTCAE:10060640 NCIT:C78337 UMLS:C0265031 cancer_care_treatment_outcome CCTO:000498 Hemorrhoidal hemorrhage CCTO:000498 Bleeding from the hemorrhoids OR A disorder characterized by bleeding from the hemorrhoids. NCI:CTCAE NCIT:C78337 A disorder characterized by the presence of dilated veins in the rectum and surrounding area OR Dilated veins in the anal canal. CCTO:000499 implies CCTO:000049 CCTO:000499 implies CCTO:001108 CCTO:000499(time_t t0) = EVENT_STATE(CCTO:000499, t0) NCI:CTCAE:10019611 NCIT:C26792 NCIT:C57819 UMLS:C0019112 UMLS:C1963134 Hemorrhoid Hemorrhoids adverse event cancer_care_treatment_outcome CCTO:000499 Hemorrhoids CCTO:000499 A disorder characterized by the presence of dilated veins in the rectum and surrounding area OR Dilated veins in the anal canal. NCI:CTCAE NCIT:C26792 Hemorrhoid NCIT:C26792 Hemorrhoids adverse event NCIT:C57819 A disorder characterized by an abnormal communication between the ileum and another organ or anatomic site OR An abnormal communication between the ileum and another organ or cavity. CCTO:000500 implies CCTO:000049 CCTO:000500 implies CCTO:001108 CCTO:000500(time_t t0) = EVENT_STATE(CCTO:000500, t0) NCI:CTCAE:10065728 NCIT:C78352 UMLS:C1699655 cancer_care_treatment_outcome CCTO:000500 Ileal fistula CCTO:000500 A disorder characterized by an abnormal communication between the ileum and another organ or anatomic site OR An abnormal communication between the ileum and another organ or cavity. NCI:CTCAE NCIT:C78352 A disorder characterized by bleeding from the ileal wall OR Bleeding originating from the ileal wall. CCTO:000501 implies CCTO:000049 CCTO:000501 implies CCTO:001108 CCTO:000501(time_t t0) = EVENT_STATE(CCTO:000501, t0) NCI:CTCAE:10055287 NCIT:C78353 UMLS:C0521597 cancer_care_treatment_outcome CCTO:000501 Ileal hemorrhage CCTO:000501 A disorder characterized by bleeding from the ileal wall OR Bleeding originating from the ileal wall. NCI:CTCAE NCIT:C78353 A disorder characterized by blockage of the normal flow of the intestinal contents in the ileum OR Blockage of the normal flow of the small intestinal contents in the ileum. CCTO:000502 implies CCTO:000049 CCTO:000502 implies CCTO:001108 CCTO:000502(time_t t0) = EVENT_STATE(CCTO:000502, t0) NCI:CTCAE:10065730 NCIT:C78354 UMLS:C1699648 cancer_care_treatment_outcome CCTO:000502 Ileal obstruction CCTO:000502 A disorder characterized by blockage of the normal flow of the intestinal contents in the ileum OR Blockage of the normal flow of the small intestinal contents in the ileum. NCI:CTCAE NCIT:C78354 A rupture in the ileal wall due to traumatic or a pathologic processes OR A disorder characterized by a rupture in the ileal wall. CCTO:000503 implies CCTO:000049 CCTO:000503 implies CCTO:001108 CCTO:000503(time_t t0) = EVENT_STATE(CCTO:000503, t0) NCI:CTCAE:10021305 NCIT:C78355 UMLS:C0559938 Perforation of Ileum cancer_care_treatment_outcome CCTO:000503 Ileal perforation CCTO:000503 A rupture in the ileal wall due to traumatic or a pathologic processes OR A disorder characterized by a rupture in the ileal wall. NCI:CTCAE NCIT:C78355 Perforation of Ileum NCIT:C78355 Narrowing of the lumen of ileum OR A disorder characterized by a narrowing of the lumen of the ileum. CCTO:000504 implies CCTO:000049 CCTO:000504 implies CCTO:001108 CCTO:000504(time_t t0) = EVENT_STATE(CCTO:000504, t0) NCI:CTCAE:10021307 NCIT:C78356 UMLS:C0400847 cancer_care_treatment_outcome CCTO:000504 Ileal stenosis CCTO:000504 Narrowing of the lumen of ileum OR A disorder characterized by a narrowing of the lumen of the ileum. NCI:CTCAE NCIT:C78356 A circumscribed inflammatory and necrotic erosive lesion in the mucosa surface of the ileum OR A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the ileum. CCTO:000505 implies CCTO:000049 CCTO:000505 implies CCTO:001108 CCTO:000505(time_t t0) = EVENT_STATE(CCTO:000505, t0) NCI:CTCAE:10021309 NCIT:C78357 UMLS:C0520564 cancer_care_treatment_outcome CCTO:000505 Ileal ulcer CCTO:000505 A circumscribed inflammatory and necrotic erosive lesion in the mucosa surface of the ileum OR A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the ileum. NCI:CTCAE NCIT:C78357 Decrease in peristalsis in the absence of a mechanical bowel obstruction OR A disorder characterized by failure of the ileum to transport intestinal contents. CCTO:000506 implies CCTO:000049 CCTO:000506 implies CCTO:001108 CCTO:000506(time_t t0) = EVENT_STATE(CCTO:000506, t0) NCI:CTCAE:10021328 NCIT:C37979 UMLS:C1258215 cancer_care_treatment_outcome CCTO:000506 Ileus CCTO:000506 Decrease in peristalsis in the absence of a mechanical bowel obstruction OR A disorder characterized by failure of the ileum to transport intestinal contents. NCI:CTCAE NCIT:C37979 Bleeding within the abdominal cavity OR A disorder characterized by bleeding in the abdominal cavity. CCTO:000507 implies CCTO:000049 CCTO:000507 implies CCTO:001108 CCTO:000507(time_t t0) = EVENT_STATE(CCTO:000507, t0) NCI:CTCAE:10055291 NCIT:C78372 UMLS:C0236178 cancer_care_treatment_outcome CCTO:000507 Intra-abdominal hemorrhage CCTO:000507 Bleeding within the abdominal cavity OR A disorder characterized by bleeding in the abdominal cavity. NCI:CTCAE NCIT:C78372 A disorder characterized by an abnormal communication between the jejunum and another organ or anatomic site OR An abnormal communication between the jejunum and another organ or cavity. CCTO:000508 implies CCTO:000049 CCTO:000508 implies CCTO:001108 CCTO:000508(time_t t0) = EVENT_STATE(CCTO:000508, t0) NCI:CTCAE:10065719 NCIT:C78396 UMLS:C0582253 cancer_care_treatment_outcome CCTO:000508 Jejunal fistula CCTO:000508 A disorder characterized by an abnormal communication between the jejunum and another organ or anatomic site OR An abnormal communication between the jejunum and another organ or cavity. NCI:CTCAE NCIT:C78396 Bleeding originating from the jejunal wall OR A disorder characterized by bleeding from the jejunal wall. CCTO:000509 implies CCTO:000049 CCTO:000509 implies CCTO:001108 CCTO:000509(time_t t0) = EVENT_STATE(CCTO:000509, t0) NCI:CTCAE:10055300 NCIT:C78397 UMLS:C0521596 cancer_care_treatment_outcome CCTO:000509 Jejunal hemorrhage CCTO:000509 Bleeding originating from the jejunal wall OR A disorder characterized by bleeding from the jejunal wall. NCI:CTCAE NCIT:C78397 Blockage of the normal flow of the small intestinal contents in the jejunum OR A disorder characterized by blockage of the normal flow of the intestinal contents in the jejunum. CCTO:000510 implies CCTO:000049 CCTO:000510 implies CCTO:001108 CCTO:000510(time_t t0) = EVENT_STATE(CCTO:000510, t0) NCI:CTCAE:10065732 NCIT:C78398 UMLS:C1699656 cancer_care_treatment_outcome CCTO:000510 Jejunal obstruction CCTO:000510 Blockage of the normal flow of the small intestinal contents in the jejunum OR A disorder characterized by blockage of the normal flow of the intestinal contents in the jejunum. NCI:CTCAE NCIT:C78398 A disorder characterized by a rupture in the jejunal wall OR A rupture in the jejunal wall due to traumatic or pathologic processes. CCTO:000511 implies CCTO:000049 CCTO:000511 implies CCTO:001108 CCTO:000511(time_t t0) = EVENT_STATE(CCTO:000511, t0) NCI:CTCAE:10023174 NCIT:C78399 UMLS:C0542147 cancer_care_treatment_outcome CCTO:000511 Jejunal perforation CCTO:000511 A disorder characterized by a rupture in the jejunal wall OR A rupture in the jejunal wall due to traumatic or pathologic processes. NCI:CTCAE NCIT:C78399 Narrowing of the lumen of jejunum OR A disorder characterized by a narrowing of the lumen of the jejunum. CCTO:000512 implies CCTO:000049 CCTO:000512 implies CCTO:001108 CCTO:000512(time_t t0) = EVENT_STATE(CCTO:000512, t0) NCI:CTCAE:10023176 NCIT:C78400 UMLS:C0151923 cancer_care_treatment_outcome CCTO:000512 Jejunal stenosis CCTO:000512 Narrowing of the lumen of jejunum OR A disorder characterized by a narrowing of the lumen of the jejunum. NCI:CTCAE NCIT:C78400 A circumscribed inflammatory and necrotic erosive lesion in the mucosa surface of the jejunum OR A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the jejunum. CCTO:000513 implies CCTO:000049 CCTO:000513 implies CCTO:001108 CCTO:000513(time_t t0) = EVENT_STATE(CCTO:000513, t0) NCI:CTCAE:10023177 NCIT:C78401 UMLS:C0267489 cancer_care_treatment_outcome CCTO:000513 Jejunal ulcer CCTO:000513 A circumscribed inflammatory and necrotic erosive lesion in the mucosa surface of the jejunum OR A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the jejunum. NCI:CTCAE NCIT:C78401 Painful sensation in the lip OR A disorder characterized by a sensation of marked discomfort of the lip. CCTO:000514 implies CCTO:000107 CCTO:000514 implies CCTO:001108 CCTO:000514(time_t t0) = EVENT_STATE(CCTO:000514, t0) NCI:CTCAE:10024561 NCIT:C56110 NCIT:C79684 UMLS:C0267028 UMLS:C1963082 Lip pain adverse event cancer_care_treatment_outcome CCTO:000514 Lip pain CCTO:000514 Painful sensation in the lip OR A disorder characterized by a sensation of marked discomfort of the lip. NCI:CTCAE NCIT:C79684 Lip pain adverse event NCIT:C56110 Bleeding from the lower gastrointestinal tract (small intestine, large intestine, and anus) OR A disorder characterized by bleeding from the lower gastrointestinal tract (small intestine, large intestine, and anus). CCTO:000515 implies CCTO:000049 CCTO:000515 implies CCTO:001108 CCTO:000515(time_t t0) = EVENT_STATE(CCTO:000515, t0) NCI:CTCAE:10051746 NCIT:C78438 UMLS:C0024050 cancer_care_treatment_outcome CCTO:000515 Lower gastrointestinal hemorrhage CCTO:000515 Bleeding from the lower gastrointestinal tract (small intestine, large intestine, and anus) OR A disorder characterized by bleeding from the lower gastrointestinal tract (small intestine, large intestine, and anus). NCI:CTCAE NCIT:C78438 A syndrome resulting from the inadequate absorption of nutrients in the small intestine. Symptoms include abdominal pain, bloating, and diarrhea OR A disorder characterized by inadequate absorption of nutrients in the small intestine. Symptoms include abdominal marked discomfort, bloating and diarrhea OR Inadequate absorption of nutrients in the small intestine. CCTO:000516 implies CCTO:000049 CCTO:000516 implies CCTO:001108 CCTO:000516(time_t t0) = EVENT_STATE(CCTO:000516, t0) NCI:CTCAE:10025476 NCIT:C113483 NCIT:C3214 NCIT:C57838 UMLS:C0024523 UMLS:C1963165 Malabsorption adverse event Malabsorption syndrome cancer_care_treatment_outcome CCTO:000516 Malabsorption CCTO:000516 A syndrome resulting from the inadequate absorption of nutrients in the small intestine. Symptoms include abdominal pain, bloating, and diarrhea OR A disorder characterized by inadequate absorption of nutrients in the small intestine. Symptoms include abdominal marked discomfort, bloating and diarrhea OR Inadequate absorption of nutrients in the small intestine. NCI:CTCAE NCIT:C113483 NCIT:C3214 Malabsorption adverse event NCIT:C57838 Malabsorption syndrome NCIT:C3214 Inflammation of the oral mucosa due to local or systemic factors OR A disorder characterized by inflammation of the oral mucosal. CCTO:000517 implies CCTO:000049 CCTO:000517 implies CCTO:001108 CCTO:000517(time_t t0) = EVENT_STATE(CCTO:000517, t0) NCI:CTCAE:10028130 NCIT:C26887 UMLS:C0038362 Oral mucositis Stomatitis cancer_care_treatment_outcome CCTO:000517 Mucositis oral CCTO:000517 Inflammation of the oral mucosa due to local or systemic factors OR A disorder characterized by inflammation of the oral mucosal. NCI:CTCAE NCIT:C26887 Oral mucositis NCIT:C26887 Stomatitis NCIT:C26887 A disorder characterized by blockage of the normal flow of the contents in the stomach OR Blockage of the normal flow of the contents in the stomach. CCTO:000518 implies CCTO:000049 CCTO:000518 implies CCTO:001108 CCTO:000518(time_t t0) = EVENT_STATE(CCTO:000518, t0) NCI:CTCAE:10029957 NCIT:C78505 UMLS:C0149700 Gastric obstruction cancer_care_treatment_outcome CCTO:000518 Obstruction gastric CCTO:000518 A disorder characterized by blockage of the normal flow of the contents in the stomach OR Blockage of the normal flow of the contents in the stomach. NCI:CTCAE NCIT:C78505 Gastric obstruction NCIT:C78505 An abnormal communication between the oral cavity and the adjacent tissues OR A disorder characterized by an abnormal communication between the oral cavity and another organ or anatomic site. CCTO:000519 implies CCTO:000049 CCTO:000519 implies CCTO:001108 CCTO:000519(time_t t0) = EVENT_STATE(CCTO:000519, t0) NCI:CTCAE:10065720 NCIT:C78506 UMLS:C1696083 cancer_care_treatment_outcome CCTO:000519 Oral cavity fistula CCTO:000519 An abnormal communication between the oral cavity and the adjacent tissues OR A disorder characterized by an abnormal communication between the oral cavity and another organ or anatomic site. NCI:CTCAE NCIT:C78506 A disorder characterized by a burning or tingling sensation on the lips, tongue or entire mouth OR A condition characterized by a burning or tingling sensation on the lips, tongue, or entire mouth. CCTO:000520 implies CCTO:000049 CCTO:000520 implies CCTO:001108 CCTO:000520(time_t t0) = EVENT_STATE(CCTO:000520, t0) NCI:CTCAE:10054520 NCIT:C62545 NCIT:C78507 UMLS:C0006430 Burning mouth syndrome cancer_care_treatment_outcome CCTO:000520 Oral dysesthesia CCTO:000520 A disorder characterized by a burning or tingling sensation on the lips, tongue or entire mouth OR A condition characterized by a burning or tingling sensation on the lips, tongue, or entire mouth. NCI:CTCAE NCIT:C62545 Burning mouth syndrome NCIT:C62545 Bleeding originating from the mouth OR A disorder characterized by bleeding from the mouth. CCTO:000521 implies CCTO:000049 CCTO:000521 implies CCTO:001108 CCTO:000521(time_t t0) = EVENT_STATE(CCTO:000521, t0) NCI:CTCAE:10030980 NCIT:C79699 UMLS:C0029163 cancer_care_treatment_outcome CCTO:000521 Oral hemorrhage CCTO:000521 Bleeding originating from the mouth OR A disorder characterized by bleeding from the mouth. NCI:CTCAE NCIT:C79699 Painful sensation in the mouth, tongue, or lips OR A disorder characterized by a sensation of marked discomfort in the mouth, tongue or lips. CCTO:000522 implies CCTO:000107 CCTO:000522 implies CCTO:001108 CCTO:000522(time_t t0) = EVENT_STATE(CCTO:000522, t0) NCI:CTCAE:10031009 NCIT:C78509 UMLS:C0221776 cancer_care_treatment_outcome CCTO:000522 Oral pain CCTO:000522 Painful sensation in the mouth, tongue, or lips OR A disorder characterized by a sensation of marked discomfort in the mouth, tongue or lips. NCI:CTCAE NCIT:C78509 Narrowing of the lumen of the pancreatic duct OR A disorder characterized by a narrowing of the lumen of the pancreatic duct. CCTO:000523 implies CCTO:000049 CCTO:000523 implies CCTO:001108 CCTO:000523(time_t t0) = EVENT_STATE(CCTO:000523, t0) NCI:CTCAE:10065703 NCIT:C78519 UMLS:C0940747 cancer_care_treatment_outcome CCTO:000523 Pancreatic duct stenosis CCTO:000523 Narrowing of the lumen of the pancreatic duct OR A disorder characterized by a narrowing of the lumen of the pancreatic duct. NCI:CTCAE NCIT:C78519 A disorder characterized by an abnormal communication between the pancreas and another organ or anatomic site OR An abnormal communication between the pancreas and another organ or cavity. CCTO:000524 implies CCTO:000049 CCTO:000524 implies CCTO:001108 CCTO:000524(time_t t0) = EVENT_STATE(CCTO:000524, t0) NCI:CTCAE:10049192 NCIT:C79701 UMLS:C0030290 cancer_care_treatment_outcome CCTO:000524 Pancreatic fistula CCTO:000524 A disorder characterized by an abnormal communication between the pancreas and another organ or anatomic site OR An abnormal communication between the pancreas and another organ or cavity. NCI:CTCAE NCIT:C79701 Bleeding originating from the pancreas OR A disorder characterized by bleeding from the pancreas. CCTO:000525 implies CCTO:000049 CCTO:000525 implies CCTO:001108 CCTO:000525(time_t t0) = EVENT_STATE(CCTO:000525, t0) NCI:CTCAE:10033626 NCIT:C78521 UMLS:C0521613 cancer_care_treatment_outcome CCTO:000525 Pancreatic hemorrhage CCTO:000525 Bleeding originating from the pancreas OR A disorder characterized by bleeding from the pancreas. NCI:CTCAE NCIT:C78521 A disorder characterized by a necrotic process occurring in the pancreas OR A necrotic process affecting the pancreas. CCTO:000526 implies CCTO:000049 CCTO:000526 implies CCTO:001108 CCTO:000526(time_t t0) = EVENT_STATE(CCTO:000526, t0) NCI:CTCAE:10058096 NCIT:C78522 UMLS:C0267953 Pancreatic necrotic lesion cancer_care_treatment_outcome CCTO:000526 Pancreatic necrosis CCTO:000526 A disorder characterized by a necrotic process occurring in the pancreas OR A necrotic process affecting the pancreas. NCI:CTCAE NCIT:C78522 Pancreatic necrotic lesion NCIT:C78522 Inflammation of the pancreas OR A disorder characterized by inflammation of the pancreas. CCTO:000527 implies CCTO:000049 CCTO:000527 implies CCTO:001108 CCTO:000527(time_t t0) = EVENT_STATE(CCTO:000527, t0) NCI:CTCAE:10033645 NCIT:C3306 NCIT:C56602 UMLS:C0030305 UMLS:C1963198 Pancreatitis adverse event cancer_care_treatment_outcome CCTO:000527 Pancreatitis CCTO:000527 Inflammation of the pancreas OR A disorder characterized by inflammation of the pancreas. NCI:CTCAE NCIT:C3306 Pancreatitis adverse event NCIT:C56602 A disorder in the gingival tissue around the teeth OR An inflammatory process of the gingival tissues and/or periodontal membrane of the teeth, resulting in an abnormally deep gingival sulcus, possibly producing periodontal pockets and loss of alveolar bone support. CCTO:000528 implies CCTO:000049 CCTO:000528 implies CCTO:001108 CCTO:000528(time_t t0) = EVENT_STATE(CCTO:000528, t0) NCI:CTCAE:10034536 NCIT:C63743 UMLS:C0017563 UMLS:C0031090 Periodontal disorder cancer_care_treatment_outcome CCTO:000528 Periodontal disease CCTO:000528 A disorder in the gingival tissue around the teeth OR An inflammatory process of the gingival tissues and/or periodontal membrane of the teeth, resulting in an abnormally deep gingival sulcus, possibly producing periodontal pockets and loss of alveolar bone support. NCI:CTCAE NCIT:C63743 Periodontal disorder NCIT:C63743 A necrotic process affecting the peritoneum OR A disorder characterized by a necrotic process occurring in the peritoneum. CCTO:000529 implies CCTO:000049 CCTO:000529 implies CCTO:001108 CCTO:000529(time_t t0) = EVENT_STATE(CCTO:000529, t0) NCI:CTCAE:10065704 NCIT:C78543 UMLS:C1696082 Peritoneal necrotic lesion cancer_care_treatment_outcome CCTO:000529 Peritoneal necrosis CCTO:000529 A necrotic process affecting the peritoneum OR A disorder characterized by a necrotic process occurring in the peritoneum. NCI:CTCAE NCIT:C78543 Peritoneal necrotic lesion NCIT:C78543 A disorder characterized by inflammation of the rectum OR An inflammatory process affecting the anus. It is usually caused by sexually transmitted infectious agents and/or inflammatory bowel disease. CCTO:000530 implies CCTO:000049 CCTO:000530 implies CCTO:001108 CCTO:000530(time_t t0) = EVENT_STATE(CCTO:000530, t0) NCI:CTCAE:10036774 NCIT:C38011 NCIT:C57857 UMLS:C0033246 UMLS:C1963216 Proctitis adverse event rectitis cancer_care_treatment_outcome CCTO:000530 Proctitis CCTO:000530 A disorder characterized by inflammation of the rectum OR An inflammatory process affecting the anus. It is usually caused by sexually transmitted infectious agents and/or inflammatory bowel disease. NCI:CTCAE NCIT:C38011 Proctitis adverse event NCIT:C57857 rectitis NCIT:C38011 A disorder characterized by an abnormal communication between the rectum and another organ or anatomic site OR An abnormal communication between the rectum and another organ or cavity. CCTO:000531 implies CCTO:000049 CCTO:000531 implies CCTO:001108 CCTO:000531(time_t t0) = EVENT_STATE(CCTO:000531, t0) NCI:CTCAE:10038062 NCIT:C79713 UMLS:C0034884 cancer_care_treatment_outcome CCTO:000531 Rectal fistula CCTO:000531 A disorder characterized by an abnormal communication between the rectum and another organ or anatomic site OR An abnormal communication between the rectum and another organ or cavity. NCI:CTCAE NCIT:C79713 A disorder characterized by bleeding from the rectal wall and discharged from the anus OR Bleeding originating from the rectal wall and discharged from the anus. CCTO:000532 implies CCTO:000049 CCTO:000532 implies CCTO:001108 CCTO:000532(time_t t0) = EVENT_STATE(CCTO:000532, t0) NCI:CTCAE:10038064 NCIT:C27054 UMLS:C0267596 cancer_care_treatment_outcome CCTO:000532 Rectal hemorrhage CCTO:000532 A disorder characterized by bleeding from the rectal wall and discharged from the anus OR Bleeding originating from the rectal wall and discharged from the anus. NCI:CTCAE NCIT:C27054 An inflammatory process affecting the mucous membrane of the rectum OR A disorder characterized by inflammation of the mucous membrane of the rectum. CCTO:000533 implies CCTO:000049 CCTO:000533 implies CCTO:001108 CCTO:000533(time_t t0) = EVENT_STATE(CCTO:000533, t0) NCI:CTCAE:10063190 NCIT:C78584 UMLS:C1328588 cancer_care_treatment_outcome CCTO:000533 Rectal mucositis CCTO:000533 An inflammatory process affecting the mucous membrane of the rectum OR A disorder characterized by inflammation of the mucous membrane of the rectum. NCI:CTCAE NCIT:C78584 A disorder characterized by a necrotic process occurring in the rectal wall OR A necrotic process involving the rectal wall. CCTO:000534 implies CCTO:000049 CCTO:000534 implies CCTO:001108 CCTO:000534(time_t t0) = EVENT_STATE(CCTO:000534, t0) NCI:CTCAE:10065709 NCIT:C78585 UMLS:C1697980 Rectal necrotic lesion cancer_care_treatment_outcome CCTO:000534 Rectal necrosis CCTO:000534 A disorder characterized by a necrotic process occurring in the rectal wall OR A necrotic process involving the rectal wall. NCI:CTCAE NCIT:C78585 Rectal necrotic lesion NCIT:C78585 A disorder characterized by blockage of the normal flow of the intestinal contents in the rectum OR Blockage of the normal flow of the intestinal contents in the rectum. CCTO:000535 implies CCTO:000049 CCTO:000535 implies CCTO:001108 CCTO:000535(time_t t0) = EVENT_STATE(CCTO:000535, t0) NCI:CTCAE:10065707 NCIT:C78586 UMLS:C1697746 cancer_care_treatment_outcome CCTO:000535 Rectal obstruction CCTO:000535 A disorder characterized by blockage of the normal flow of the intestinal contents in the rectum OR Blockage of the normal flow of the intestinal contents in the rectum. NCI:CTCAE NCIT:C78586 Pain in the rectal area OR A disorder characterized by a sensation of marked discomfort in the rectal region. CCTO:000536 implies CCTO:000107 CCTO:000536 implies CCTO:001108 CCTO:000536(time_t t0) = EVENT_STATE(CCTO:000536, t0) NCI:CTCAE:10038072 NCIT:C78587 UMLS:C0034886 cancer_care_treatment_outcome CCTO:000536 Rectal pain CCTO:000536 Pain in the rectal area OR A disorder characterized by a sensation of marked discomfort in the rectal region. NCI:CTCAE NCIT:C78587 A disorder characterized by a rupture in the rectal wall OR An rupture in the rectal wall due to traumatic or pathologic processes. CCTO:000537 implies CCTO:000049 CCTO:000537 implies CCTO:001108 CCTO:000537(time_t t0) = EVENT_STATE(CCTO:000537, t0) NCI:CTCAE:10038073 NCIT:C78588 UMLS:C0341402 cancer_care_treatment_outcome CCTO:000537 Rectal perforation CCTO:000537 A disorder characterized by a rupture in the rectal wall OR An rupture in the rectal wall due to traumatic or pathologic processes. NCI:CTCAE NCIT:C78588 Narrowing of the rectal lumen OR A disorder characterized by a narrowing of the lumen of the rectum. CCTO:000538 implies CCTO:000049 CCTO:000538 implies CCTO:001108 CCTO:000538(time_t t0) = EVENT_STATE(CCTO:000538, t0) NCI:CTCAE:10038079 NCIT:C78589 UMLS:C0267581 cancer_care_treatment_outcome CCTO:000538 Rectal stenosis CCTO:000538 Narrowing of the rectal lumen OR A disorder characterized by a narrowing of the lumen of the rectum. NCI:CTCAE NCIT:C78589 A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the rectum OR A circumscribed inflammatory and necrotic erosive lesion in the mucosa surface of the rectum. CCTO:000539 implies CCTO:000049 CCTO:000539 implies CCTO:001108 CCTO:000539(time_t t0) = EVENT_STATE(CCTO:000539, t0) NCI:CTCAE:10038080 NCIT:C78590 UMLS:C0400839 cancer_care_treatment_outcome CCTO:000539 Rectal ulcer CCTO:000539 A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the rectum OR A circumscribed inflammatory and necrotic erosive lesion in the mucosa surface of the rectum. NCI:CTCAE NCIT:C78590 Bleeding originating in the retroperitoneal area OR A disorder characterized by bleeding from the retroperitoneal area. CCTO:000540 implies CCTO:000049 CCTO:000540 implies CCTO:001108 CCTO:000540(time_t t0) = EVENT_STATE(CCTO:000540, t0) NCI:CTCAE:10038981 NCIT:C26944 UMLS:C0151705 cancer_care_treatment_outcome CCTO:000540 Retroperitoneal hemorrhage CCTO:000540 Bleeding originating in the retroperitoneal area OR A disorder characterized by bleeding from the retroperitoneal area. NCI:CTCAE NCIT:C26944 An inflammatory process affecting the salivary duct OR A disorder characterized by inflammation of the salivary duct. CCTO:000541 implies CCTO:000049 CCTO:000541 implies CCTO:001108 CCTO:000541(time_t t0) = EVENT_STATE(CCTO:000541, t0) NCI:CTCAE:10056681 NCIT:C78600 UMLS:C1112516 cancer_care_treatment_outcome CCTO:000541 Salivary duct inflammation CCTO:000541 An inflammatory process affecting the salivary duct OR A disorder characterized by inflammation of the salivary duct. NCI:CTCAE NCIT:C78600 An abnormal communication between a salivary gland and another organ or anatomic site OR A disorder characterized by an abnormal communication between a salivary gland and another organ or anatomic site. CCTO:000542 implies CCTO:000049 CCTO:000542 implies CCTO:001108 CCTO:000542(time_t t0) = EVENT_STATE(CCTO:000542, t0) NCI:CTCAE:10039411 NCIT:C57868 NCIT:C79715 UMLS:C0036094 UMLS:C2700637 Salivary gland fistula adverse event cancer_care_treatment_outcome CCTO:000542 Salivary gland fistula CCTO:000542 An abnormal communication between a salivary gland and another organ or anatomic site OR A disorder characterized by an abnormal communication between a salivary gland and another organ or anatomic site. NCI:CTCAE NCIT:C79715 Salivary gland fistula adverse event NCIT:C57868 An inflammatory process affecting the mucous membrane of the small intestine OR A disorder characterized by inflammation of the mucous membrane of the small intestine. CCTO:000543 implies CCTO:000049 CCTO:000543 implies CCTO:001108 CCTO:000543(time_t t0) = EVENT_STATE(CCTO:000543, t0) NCI:CTCAE:10065710 NCIT:C78613 UMLS:C1698626 cancer_care_treatment_outcome CCTO:000543 Small intestinal mucositis CCTO:000543 An inflammatory process affecting the mucous membrane of the small intestine OR A disorder characterized by inflammation of the mucous membrane of the small intestine. NCI:CTCAE NCIT:C78613 Blockage of the normal flow of the small intestinal contents OR A disorder characterized by blockage of the normal flow of the intestinal contents. CCTO:000544 implies CCTO:000049 CCTO:000544 implies CCTO:001108 CCTO:000544(time_t t0) = EVENT_STATE(CCTO:000544, t0) NCI:CTCAE:10041101 NCIT:C78615 UMLS:C0235329 cancer_care_treatment_outcome CCTO:000544 Small intestinal obstruction CCTO:000544 Blockage of the normal flow of the small intestinal contents OR A disorder characterized by blockage of the normal flow of the intestinal contents. NCI:CTCAE NCIT:C78615 A rupture in the wall of the small intestine due to traumatic or pathologic processes OR A disorder characterized by a rupture in the small intestine wall. CCTO:000545 implies CCTO:000049 CCTO:000545 implies CCTO:001108 CCTO:000545(time_t t0) = EVENT_STATE(CCTO:000545, t0) NCI:CTCAE:10041103 NCIT:C78616 UMLS:C0151739 cancer_care_treatment_outcome CCTO:000545 Small intestinal perforation CCTO:000545 A rupture in the wall of the small intestine due to traumatic or pathologic processes OR A disorder characterized by a rupture in the small intestine wall. NCI:CTCAE NCIT:C78616 A disorder characterized by a narrowing of the lumen of the small intestine OR Narrowing of the lumen of small intestine. CCTO:000546 implies CCTO:000049 CCTO:000546 implies CCTO:001108 CCTO:000546(time_t t0) = EVENT_STATE(CCTO:000546, t0) NCI:CTCAE:10062263 NCIT:C78617 UMLS:C0151924 cancer_care_treatment_outcome CCTO:000546 Small intestinal stenosis CCTO:000546 A disorder characterized by a narrowing of the lumen of the small intestine OR Narrowing of the lumen of small intestine. NCI:CTCAE NCIT:C78617 A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the small intestine OR A circumscribed inflammatory and necrotic erosive lesion in the mucosa surface of the small intestine. CCTO:000547 implies CCTO:000049 CCTO:000547 implies CCTO:001108 CCTO:000547(time_t t0) = EVENT_STATE(CCTO:000547, t0) NCI:CTCAE:10041133 NCIT:C78619 UMLS:C0151977 Small intestinal ulcer cancer_care_treatment_outcome CCTO:000547 Small intestine ulcer CCTO:000547 A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the small intestine OR A circumscribed inflammatory and necrotic erosive lesion in the mucosa surface of the small intestine. NCI:CTCAE NCIT:C78619 Small intestinal ulcer NCIT:C78619 A disorder characterized by a sensation of marked discomfort in the stomach OR A painful sensation in the stomach. CCTO:000548 implies CCTO:000107 CCTO:000548 implies CCTO:001108 CCTO:000548(time_t t0) = EVENT_STATE(CCTO:000548, t0) NCI:CTCAE:10042112 NCIT:C56230 NCIT:C78630 UMLS:C0221512 UMLS:C1963242 Gastric pain Stomach pain adverse event cancer_care_treatment_outcome CCTO:000548 Stomach pain CCTO:000548 A disorder characterized by a sensation of marked discomfort in the stomach OR A painful sensation in the stomach. NCI:CTCAE NCIT:C78630 Gastric pain NCIT:C78630 Stomach pain adverse event NCIT:C56230 A disorder characterized by a pathological process of the teeth occurring during tooth development OR A disorder of the teeth arising during odontogenesis. CCTO:000549 implies CCTO:000049 CCTO:000549 implies CCTO:001108 CCTO:000549(time_t t0) = EVENT_STATE(CCTO:000549, t0) NCI:CTCAE:10044030 NCIT:C35596 UMLS:C0494698 Dental developmental disorder cancer_care_treatment_outcome CCTO:000549 Tooth development disorder CCTO:000549 A disorder characterized by a pathological process of the teeth occurring during tooth development OR A disorder of the teeth arising during odontogenesis. NCI:CTCAE NCIT:C35596 Dental developmental disorder NCIT:C35596 A change in tooth color. Causes may be local or systemic and include tobacco use, foods, dental plaques, caries, restorative filling materials, trauma, medications, infections, hereditary diseases, and nutritional deficiencies OR A disorder characterized by a change in tooth hue or tint. CCTO:000550 implies CCTO:000049 CCTO:000550 implies CCTO:001108 CCTO:000550(time_t t0) = EVENT_STATE(CCTO:000550, t0) NCI:CTCAE:10044031 NCIT:C80112 UMLS:C0040434 cancer_care_treatment_outcome CCTO:000550 Tooth discoloration CCTO:000550 A change in tooth color. Causes may be local or systemic and include tobacco use, foods, dental plaques, caries, restorative filling materials, trauma, medications, infections, hereditary diseases, and nutritional deficiencies OR A disorder characterized by a change in tooth hue or tint. NCI:CTCAE NCIT:C80112 A disorder characterized by a sensation of marked discomfort in the tooth OR A painful sensation originating from a tooth. CCTO:000551 implies CCTO:000049 CCTO:000551 implies CCTO:001108 CCTO:000551(time_t t0) = EVENT_STATE(CCTO:000551, t0) NCI:CTCAE:10044055 NCIT:C78640 UMLS:C0040460 cancer_care_treatment_outcome CCTO:000551 Toothache CCTO:000551 A disorder characterized by a sensation of marked discomfort in the tooth OR A painful sensation originating from a tooth. NCI:CTCAE NCIT:C78640 Inflammation of the cecum, usually accompanied by neutropenia OR A disorder characterized by inflammation of the cecum. CCTO:000552 implies CCTO:000049 CCTO:000552 implies CCTO:001108 CCTO:000552(time_t t0) = EVENT_STATE(CCTO:000552, t0) NCI:CTCAE:10045271 NCIT:C38043 UMLS:C0267537 UMLS:C0400823 Neutropenic colitis cancer_care_treatment_outcome CCTO:000552 Typhlitis CCTO:000552 Inflammation of the cecum, usually accompanied by neutropenia OR A disorder characterized by inflammation of the cecum. NCI:CTCAE NCIT:C38043 Neutropenic colitis NCIT:C38043 A disorder characterized by bleeding from the upper gastrointestinal tract (oral cavity, pharynx, esophagus, and stomach) OR Bleeding originating from the upper gastrointestinal tract (oral cavity, pharynx, esophagus, and stomach). CCTO:000553 implies CCTO:000049 CCTO:000553 implies CCTO:001108 CCTO:000553(time_t t0) = EVENT_STATE(CCTO:000553, t0) NCI:CTCAE:10055356 NCIT:C78660 UMLS:C0041909 cancer_care_treatment_outcome CCTO:000553 Upper gastrointestinal hemorrhage CCTO:000553 A disorder characterized by bleeding from the upper gastrointestinal tract (oral cavity, pharynx, esophagus, and stomach) OR Bleeding originating from the upper gastrointestinal tract (oral cavity, pharynx, esophagus, and stomach). NCI:CTCAE NCIT:C78660 A question about whether an individual has been vomiting OR A question about an individual's distress from their vomiting OR A disorder characterized by the reflexive act of ejecting the contents of the stomach through the mouth OR A question about whether an individual is or was bothered by vomiting OR A question about the usual severity of an individual's vomiting OR A question about how often an individual vomits or vomited OR Forceful ejection of the contents of the stomach through the mouth. CCTO:000554 implies CCTO:000049 CCTO:000554 implies CCTO:001108 CCTO:000554(time_t t0) = EVENT_STATE(CCTO:000554, t0) NCI:CTCAE:10047700 NCIT:C115346 NCIT:C125278 NCIT:C125310 NCIT:C125342 NCIT:C125647 NCIT:C3442 NCIT:C57896 UMLS:C0042963 UMLS:C0042965 UMLS:C1963281 Bothered by Vomiting Emesis Frequency of Vomiting Have been vomiting How much distress vomiting How often vomiting I have been vomiting Usual severity vomiting Vomiting adverse event Vomiting frequency vomit cancer_care_treatment_outcome CCTO:000554 Vomiting CCTO:000554 A question about whether an individual has been vomiting OR A question about an individual's distress from their vomiting OR A disorder characterized by the reflexive act of ejecting the contents of the stomach through the mouth OR A question about whether an individual is or was bothered by vomiting OR A question about the usual severity of an individual's vomiting OR A question about how often an individual vomits or vomited OR Forceful ejection of the contents of the stomach through the mouth. NCI:CTCAE NCIT:C115346 NCIT:C125278 NCIT:C125310 NCIT:C125342 NCIT:C125647 NCIT:C3442 Bothered by Vomiting NCIT:C125647 Emesis NCIT:C3442 Frequency of Vomiting NCIT:C125278 Have been vomiting NCIT:C115346 How much distress vomiting NCIT:C125342 How often vomiting NCIT:C125278 I have been vomiting NCIT:C115346 Usual severity vomiting NCIT:C125310 Vomiting adverse event NCIT:C57896 Vomiting frequency NCIT:C125278 vomit NCIT:C3442 Shivering or moderate tremors of the body often accompanied by a cold sensation OR A disorder characterized by a sensation of cold that often marks a physiologic response to sweating after a fever. CCTO:000555 implies CCTO:000049 CCTO:000555 implies CCTO:001103 CCTO:000555(time_t t0) = EVENT_STATE(CCTO:000555, t0) NCI:CTCAE:10008531 NCIT:C35143 UMLS:C0085593 Chill cancer_care_treatment_outcome CCTO:000555 Chills CCTO:000555 Shivering or moderate tremors of the body often accompanied by a cold sensation OR A disorder characterized by a sensation of cold that often marks a physiologic response to sweating after a fever. NCI:CTCAE NCIT:C35143 Chill NCIT:C35143 A disorder characterized by cessation of life occurring during the first 28 days of life OR Death of a live newborn during the first 28 days of life. CCTO:000556 implies CCTO:000049 CCTO:000556 implies CCTO:001103 CCTO:000556(time_t t0) = EVENT_STATE(CCTO:000556, t0) NCI:CTCAE:10011912 NCIT:C80082 UMLS:C0410916 Neonatal death cancer_care_treatment_outcome CCTO:000556 Death neonatal CCTO:000556 A disorder characterized by cessation of life occurring during the first 28 days of life OR Death of a live newborn during the first 28 days of life. NCI:CTCAE NCIT:C80082 Neonatal death NCIT:C80082 Swelling due to an excessive accumulation of fluid in facial tissues OR A disorder characterized by swelling due to excessive fluid accumulation in facial tissues. CCTO:000557 implies CCTO:000049 CCTO:000557 implies CCTO:001103 CCTO:000557(time_t t0) = EVENT_STATE(CCTO:000557, t0) NCI:CTCAE:10014222 NCIT:C78289 UMLS:C0542571 Face edema cancer_care_treatment_outcome CCTO:000557 Edema face CCTO:000557 Swelling due to an excessive accumulation of fluid in facial tissues OR A disorder characterized by swelling due to excessive fluid accumulation in facial tissues. NCI:CTCAE NCIT:C78289 Face edema NCIT:C78289 A disorder characterized by swelling due to excessive fluid accumulation in the upper or lower extremities OR Swelling due to an excessive accumulation of fluid in the upper or lower extremities. CCTO:000558 implies CCTO:000049 CCTO:000558 implies CCTO:001103 CCTO:000558(time_t t0) = EVENT_STATE(CCTO:000558, t0) NCI:CTCAE:10050068 NCIT:C78262 UMLS:C0085649 Limbs edema Peripheral edema cancer_care_treatment_outcome CCTO:000558 Edema limbs CCTO:000558 A disorder characterized by swelling due to excessive fluid accumulation in the upper or lower extremities OR Swelling due to an excessive accumulation of fluid in the upper or lower extremities. NCI:CTCAE NCIT:C78262 Limbs edema NCIT:C78262 Peripheral edema NCIT:C78262 Swelling due to an excessive accumulation of fluid in trunk area OR A disorder characterized by swelling due to excessive fluid accumulation in the trunk area. CCTO:000559 implies CCTO:000049 CCTO:000559 implies CCTO:001103 CCTO:000559(time_t t0) = EVENT_STATE(CCTO:000559, t0) NCI:CTCAE:10058720 NCIT:C78263 UMLS:C0578541 cancer_care_treatment_outcome CCTO:000559 Edema trunk CCTO:000559 Swelling due to an excessive accumulation of fluid in trunk area OR A disorder characterized by swelling due to excessive fluid accumulation in the trunk area. NCI:CTCAE NCIT:C78263 Painful sensation in the face OR A disorder characterized by a sensation of marked discomfort in the face. CCTO:000560 implies CCTO:000107 CCTO:000560(time_t t0) = EVENT_STATE(CCTO:000560, t0) NCI:CTCAE:10016059 NCIT:C79594 UMLS:C0015468 cancer_care_treatment_outcome CCTO:000560 Facial pain CCTO:000560 Painful sensation in the face OR A disorder characterized by a sensation of marked discomfort in the face. NCI:CTCAE NCIT:C79594 A disorder characterized by elevation of the body's temperature above the upper limit of normal OR Elevation of body temperature above normal due to inflammatory or immune responses. CCTO:000561 implies CCTO:000049 CCTO:000561 implies CCTO:001103 CCTO:000561(time_t t0) = EVENT_STATE(CCTO:000561, t0) NCI:CTCAE:10016558 NCIT:C3038 UMLS:C0015967 UMLS:C0424755 Pyrexia cancer_care_treatment_outcome CCTO:000561 Fever CCTO:000561 A disorder characterized by elevation of the body's temperature above the upper limit of normal OR Elevation of body temperature above normal due to inflammatory or immune responses. NCI:CTCAE NCIT:C3038 Pyrexia NCIT:C3038 A disorder characterized by a group of symptoms similar to those observed in patients with the flu. It includes fever, chills, body aches, malaise, loss of appetite and dry cough OR Complaints describing a pattern similar to influenza, and may include fever, chills, muscle or body aches, cough, sore throat, rhinitis or fatigue. CCTO:000562 implies CCTO:000049 CCTO:000562 implies CCTO:001103 CCTO:000562(time_t t0) = EVENT_STATE(CCTO:000562, t0) NCI:CTCAE:10016791 NCIT:C78302 UMLS:C0392171 UMLS:C0521839 Flu-like symptoms Influenza-like illness cancer_care_treatment_outcome CCTO:000562 Flu like symptoms CCTO:000562 A disorder characterized by a group of symptoms similar to those observed in patients with the flu. It includes fever, chills, body aches, malaise, loss of appetite and dry cough OR Complaints describing a pattern similar to influenza, and may include fever, chills, muscle or body aches, cough, sore throat, rhinitis or fatigue. NCI:CTCAE NCIT:C78302 Flu-like symptoms NCIT:C78302 Influenza-like illness NCIT:C78302 A finding referring to walking difficulties OR A disorder characterized by walking difficulties. CCTO:000563 implies CCTO:000049 CCTO:000563 implies CCTO:001103 CCTO:000563(time_t t0) = EVENT_STATE(CCTO:000563, t0) NCI:CTCAE:10017577 NCIT:C78303 UMLS:C0575081 cancer_care_treatment_outcome CCTO:000563 Gait disturbance CCTO:000563 A finding referring to walking difficulties OR A disorder characterized by walking difficulties. NCI:CTCAE NCIT:C78303 Abnormally low body temperature OR A disorder characterized by an abnormally low body temperature. Treatment is required when the body temperature is 35C (95F) or below OR Abnormally low body temperature. CCTO:000564 implies CCTO:000049 CCTO:000564 implies CCTO:001103 CCTO:000564(time_t t0) = EVENT_STATE(CCTO:000564, t0) NCI:CTCAE:10021113 NCIT:C50523 NCIT:C55332 NCIT:C78351 UMLS:C0020672 UMLS:C1963170 Body temperature, decreased Decreased body temperature Decreased core body temperature Hypothermia adverse event Temperature, decreased body cancer_care_treatment_outcome CCTO:000564 Hypothermia CCTO:000564 Abnormally low body temperature OR A disorder characterized by an abnormally low body temperature. Treatment is required when the body temperature is 35C (95F) or below OR Abnormally low body temperature. NCI:CTCAE NCIT:C50523 NCIT:C78351 Body temperature, decreased NCIT:C50523 Decreased body temperature NCIT:C50523 Decreased core body temperature NCIT:C50523 Hypothermia adverse event NCIT:C55332 Temperature, decreased body NCIT:C50523 A reaction to the infusion of pharmacological or biological substances. Symptoms may appear within minutes to hours following the infusion and may include pruritus, flushing, swelling, dyspnea, bronchospasm, and hypotension OR A disorder characterized by adverse reaction to the infusion of pharmacological or biological substances. CCTO:000565 implies CCTO:000049 CCTO:000565 implies CCTO:001103 CCTO:000565(time_t t0) = EVENT_STATE(CCTO:000565, t0) NCI:CTCAE:10051792 NCIT:C78361 UMLS:C0948715 Infusion-related reaction cancer_care_treatment_outcome CCTO:000565 Infusion related reaction CCTO:000565 A reaction to the infusion of pharmacological or biological substances. Symptoms may appear within minutes to hours following the infusion and may include pruritus, flushing, swelling, dyspnea, bronchospasm, and hypotension OR A disorder characterized by adverse reaction to the infusion of pharmacological or biological substances. NCI:CTCAE NCIT:C78361 Infusion-related reaction NCIT:C78361 A disorder characterized by leakage of a pharmacologic or a biologic substance from the infusion site into the surrounding tissue. Signs and symptoms include induration, erythema, swelling, burning sensation and marked discomfort at the infusion site OR Leakage of a pharmacologic or a biological substance from the infusion site into the surrounding tissue. Signs and symptoms include induration, erythema, swelling, burning sensation, and pain at the infusion site. CCTO:000566 implies CCTO:000049 CCTO:000566 implies CCTO:001103 CCTO:000566(time_t t0) = EVENT_STATE(CCTO:000566, t0) NCI:CTCAE:10064774 NCIT:C78362 UMLS:C1608954 cancer_care_treatment_outcome CCTO:000566 Infusion site extravasation CCTO:000566 A disorder characterized by leakage of a pharmacologic or a biologic substance from the infusion site into the surrounding tissue. Signs and symptoms include induration, erythema, swelling, burning sensation and marked discomfort at the infusion site OR Leakage of a pharmacologic or a biological substance from the infusion site into the surrounding tissue. Signs and symptoms include induration, erythema, swelling, burning sensation, and pain at the infusion site. NCI:CTCAE NCIT:C78362 Feelings of annoyance, impatience, and anger OR A disorder characterized by an abnormal responsiveness to stimuli or physiological arousal; may be in response to pain, fright, a drug, an emotional situation or a medical condition OR Excited response to stimuli. CCTO:000567 implies CCTO:000049 CCTO:000567 implies CCTO:001103 CCTO:000567(time_t t0) = EVENT_STATE(CCTO:000567, t0) NCI:CTCAE:10022998 NCIT:C50623 NCIT:C77966 UMLS:C0022107 UMLS:C0441723 UMLS:C1706307 UMLS:C2700617 Irritation cancer_care_treatment_outcome CCTO:000567 Irritability CCTO:000567 Feelings of annoyance, impatience, and anger OR A disorder characterized by an abnormal responsiveness to stimuli or physiological arousal; may be in response to pain, fright, a drug, an emotional situation or a medical condition OR Excited response to stimuli. NCI:CTCAE NCIT:C50623 NCIT:C77966 Irritation NCIT:C77966 Swelling due to an excessive accumulation of fluid at a specific anatomic site OR A disorder characterized by swelling due to excessive fluid accumulation at a specific anatomic site. CCTO:000568 implies CCTO:000226 CCTO:000568 implies CCTO:001103 CCTO:000568(time_t t0) = EVENT_STATE(CCTO:000568, t0) NCI:CTCAE:10062466 NCIT:C78437 UMLS:C0013609 cancer_care_treatment_outcome CCTO:000568 Localized edema CCTO:000568 Swelling due to an excessive accumulation of fluid at a specific anatomic site OR A disorder characterized by swelling due to excessive fluid accumulation at a specific anatomic site. NCI:CTCAE NCIT:C78437 A feeling of general discomfort or uneasiness, an out-of-sorts feeling OR A disorder characterized by a feeling of general discomfort or uneasiness, an out-of-sorts feeling. CCTO:000569 implies CCTO:000049 CCTO:000569 implies CCTO:001103 CCTO:000569(time_t t0) = EVENT_STATE(CCTO:000569, t0) NCI:CTCAE:10025482 NCIT:C3832 UMLS:C0231218 cancer_care_treatment_outcome CCTO:000569 Malaise CCTO:000569 A feeling of general discomfort or uneasiness, an out-of-sorts feeling OR A disorder characterized by a feeling of general discomfort or uneasiness, an out-of-sorts feeling. NCI:CTCAE NCIT:C3832 A disorder characterized by progressive deterioration of the lungs, liver, kidney and clotting mechanisms OR Complete impairment of two or more organs or organ systems. CCTO:000570 implies CCTO:000049 CCTO:000570 implies CCTO:001103 CCTO:000570(time_t t0) = EVENT_STATE(CCTO:000570, t0) NCI:CTCAE:10028154 NCIT:C55283 NCIT:C75568 UMLS:C0026766 UMLS:C1963169 Death Adverse Event Due to Multi-Organ Failure Not Associated with More Specific CTCAE Term Multiple organ failure Multiple system failure cancer_care_treatment_outcome CCTO:000570 Multi-organ failure CCTO:000570 A disorder characterized by progressive deterioration of the lungs, liver, kidney and clotting mechanisms OR Complete impairment of two or more organs or organ systems. NCI:CTCAE NCIT:C75568 Death Adverse Event Due to Multi-Organ Failure Not Associated with More Specific CTCAE Term NCIT:C55283 Multiple organ failure NCIT:C75568 Multiple system failure NCIT:C75568 A disorder characterized by swelling due to an accumulation of excessive fluid in the neck OR Swelling due to an accumulation of excessive fluid in the neck. CCTO:000571 implies CCTO:000226 CCTO:000571 implies CCTO:001103 CCTO:000571(time_t t0) = EVENT_STATE(CCTO:000571, t0) NCI:CTCAE:10054482 NCIT:C78501 UMLS:C0240464 cancer_care_treatment_outcome CCTO:000571 Neck edema CCTO:000571 A disorder characterized by swelling due to an accumulation of excessive fluid in the neck OR Swelling due to an accumulation of excessive fluid in the neck. NCI:CTCAE NCIT:C78501 A disorder characterized by discomfort in the chest unrelated to a heart disorder OR Pain in the chest unrelated to a heart disorder. CCTO:000572 implies CCTO:000107 CCTO:000572(time_t t0) = EVENT_STATE(CCTO:000572, t0) NCI:CTCAE:10062501 NCIT:C78504 UMLS:C0476281 cancer_care_treatment_outcome CCTO:000572 Non-cardiac chest pain CCTO:000572 A disorder characterized by discomfort in the chest unrelated to a heart disorder OR Pain in the chest unrelated to a heart disorder. NCI:CTCAE NCIT:C78504 An unexpected cessation of life that cannot be attributed to a CTCAE term associated with Grade 5. CCTO:000573 implies CCTO:000049 CCTO:000573 implies CCTO:001103 CCTO:000573(time_t t0) = EVENT_STATE(CCTO:000573, t0) NCI:CTCAE:10042435 cancer_care_treatment_outcome CCTO:000573 Sudden death NOS CCTO:000573 An unexpected cessation of life that cannot be attributed to a CTCAE term associated with Grade 5. NCI:CTCAE A disorder characterized by a narrowing of the lumen of the bile duct OR Narrowing or stricture of the bile duct. CCTO:000574 implies CCTO:000049 CCTO:000574 implies CCTO:001117 CCTO:000574(time_t t0) = EVENT_STATE(CCTO:000574, t0) NCI:CTCAE:10051341 NCIT:C78182 UMLS:C0267925 cancer_care_treatment_outcome CCTO:000574 Bile duct stenosis CCTO:000574 A disorder characterized by a narrowing of the lumen of the bile duct OR Narrowing or stricture of the bile duct. NCI:CTCAE NCIT:C78182 An abnormal communication between the bile ducts and another organ or cavity OR A disorder characterized by an abnormal communication between the bile ducts and another organ or anatomic site. CCTO:000575 implies CCTO:000049 CCTO:000575 implies CCTO:001117 CCTO:000575(time_t t0) = EVENT_STATE(CCTO:000575, t0) NCI:CTCAE:10004665 NCIT:C79540 UMLS:C0005417 cancer_care_treatment_outcome CCTO:000575 Biliary fistula CCTO:000575 An abnormal communication between the bile ducts and another organ or cavity OR A disorder characterized by an abnormal communication between the bile ducts and another organ or anatomic site. NCI:CTCAE NCIT:C79540 A disorder characterized by inflammation involving the gallbladder. It may be associated with the presence of gallstones OR An acute or chronic inflammation involving the gallbladder wall. It may be associated with the presence of gallstones. CCTO:000576 implies CCTO:000049 CCTO:000576 implies CCTO:001117 CCTO:000576(time_t t0) = EVENT_STATE(CCTO:000576, t0) NCI:CTCAE:10008612 NCIT:C34465 NCIT:C56575 UMLS:C0008325 UMLS:C1963083 Cholecystitis adverse event cancer_care_treatment_outcome CCTO:000576 Cholecystitis CCTO:000576 A disorder characterized by inflammation involving the gallbladder. It may be associated with the presence of gallstones OR An acute or chronic inflammation involving the gallbladder wall. It may be associated with the presence of gallstones. NCI:CTCAE NCIT:C34465 Cholecystitis adverse event NCIT:C56575 A disorder characterized by an abnormal communication between the gallbladder and another organ or anatomic site OR An abnormal communication between the gallbladder and another organ or cavity. CCTO:000577 implies CCTO:000049 CCTO:000577 implies CCTO:001117 CCTO:000577(time_t t0) = EVENT_STATE(CCTO:000577, t0) NCI:CTCAE:10017631 NCIT:C57808 NCIT:C78305 UMLS:C0156216 UMLS:C1963110 Gallbladder fistula adverse event cancer_care_treatment_outcome CCTO:000577 Gallbladder fistula CCTO:000577 A disorder characterized by an abnormal communication between the gallbladder and another organ or anatomic site OR An abnormal communication between the gallbladder and another organ or cavity. NCI:CTCAE NCIT:C78305 Gallbladder fistula adverse event NCIT:C57808 A disorder characterized by a necrotic process occurring in the gallbladder OR A necrotic process occurring in the gallbladder. CCTO:000578 implies CCTO:000049 CCTO:000578 implies CCTO:001117 CCTO:000578(time_t t0) = EVENT_STATE(CCTO:000578, t0) NCI:CTCAE:10059446 NCIT:C57809 NCIT:C78307 UMLS:C1167767 UMLS:C1963114 Gallbladder necrosis adverse event Gallbladder necrotic lesion cancer_care_treatment_outcome CCTO:000578 Gallbladder necrosis CCTO:000578 A disorder characterized by a necrotic process occurring in the gallbladder OR A necrotic process occurring in the gallbladder. NCI:CTCAE NCIT:C78307 Gallbladder necrosis adverse event NCIT:C57809 Gallbladder necrotic lesion NCIT:C78307 Blockage of the normal flow of the contents of the gallbladder OR A disorder characterized by blockage of the normal flow of the contents of the gallbladder. CCTO:000579 implies CCTO:000049 CCTO:000579 implies CCTO:001117 CCTO:000579(time_t t0) = EVENT_STATE(CCTO:000579, t0) NCI:CTCAE:10017636 NCIT:C57810 NCIT:C78308 UMLS:C0156214 UMLS:C1964021 Gallbladder obstruction adverse event cancer_care_treatment_outcome CCTO:000579 Gallbladder obstruction CCTO:000579 Blockage of the normal flow of the contents of the gallbladder OR A disorder characterized by blockage of the normal flow of the contents of the gallbladder. NCI:CTCAE NCIT:C78308 Gallbladder obstruction adverse event NCIT:C57810 A disorder characterized by a sensation of marked discomfort in the gallbladder region OR Painful sensation in the gallbladder region. CCTO:000580 implies CCTO:000107 CCTO:000580 implies CCTO:001117 CCTO:000580(time_t t0) = EVENT_STATE(CCTO:000580, t0) NCI:CTCAE:10017638 NCIT:C56080 NCIT:C78304 UMLS:C0151824 UMLS:C1963072 Gallbladder pain adverse event cancer_care_treatment_outcome CCTO:000580 Gallbladder pain CCTO:000580 A disorder characterized by a sensation of marked discomfort in the gallbladder region OR Painful sensation in the gallbladder region. NCI:CTCAE NCIT:C78304 Gallbladder pain adverse event NCIT:C56080 A disorder characterized by a rupture in the gallbladder wall OR A rupture in the gallbladder wall caused by traumatic or pathologic processes. CCTO:000581 implies CCTO:000049 CCTO:000581 implies CCTO:001117 CCTO:000581(time_t t0) = EVENT_STATE(CCTO:000581, t0) NCI:CTCAE:10017639 NCIT:C57811 NCIT:C78309 UMLS:C0156215 UMLS:C1963204 Gallbladder perforation adverse event cancer_care_treatment_outcome CCTO:000581 Gallbladder perforation CCTO:000581 A disorder characterized by a rupture in the gallbladder wall OR A rupture in the gallbladder wall caused by traumatic or pathologic processes. NCI:CTCAE NCIT:C78309 Gallbladder perforation adverse event NCIT:C57811 A disorder characterized by the inability of the liver to metabolize chemicals in the body. Laboratory test results reveal abnormal plasma levels of ammonia, bilirubin, lactic dehydrogenase, and alkaline phosphatase OR A disorder characterized by the inability of the liver to metabolize chemicals in the body. Causes include cirrhosis and drug-induced hepatotoxicity. Signs and symptoms include jaundice and encephalopathy. Laboratory test results reveal abnormal plasma levels of ammonia, bilirubin, lactic dehydrogenase, and alkaline phosphatase. CCTO:000582 implies CCTO:000049 CCTO:000582 implies CCTO:001117 CCTO:000582(time_t t0) = EVENT_STATE(CCTO:000582, t0) NCI:CTCAE:10019663 NCIT:C26922 UMLS:C0085605 Liver failure cancer_care_treatment_outcome CCTO:000582 Hepatic failure CCTO:000582 A disorder characterized by the inability of the liver to metabolize chemicals in the body. Laboratory test results reveal abnormal plasma levels of ammonia, bilirubin, lactic dehydrogenase, and alkaline phosphatase OR A disorder characterized by the inability of the liver to metabolize chemicals in the body. Causes include cirrhosis and drug-induced hepatotoxicity. Signs and symptoms include jaundice and encephalopathy. Laboratory test results reveal abnormal plasma levels of ammonia, bilirubin, lactic dehydrogenase, and alkaline phosphatase. NCI:CTCAE NCIT:C26922 Liver failure NCIT:C26922 Bleeding originating from the liver OR A disorder characterized by bleeding from the liver. CCTO:000583 implies CCTO:000049 CCTO:000583 implies CCTO:001117 CCTO:000583(time_t t0) = EVENT_STATE(CCTO:000583, t0) NCI:CTCAE:10019678 NCIT:C78338 UMLS:C0235912 cancer_care_treatment_outcome CCTO:000583 Hepatic hemorrhage CCTO:000583 Bleeding originating from the liver OR A disorder characterized by bleeding from the liver. NCI:CTCAE NCIT:C78338 A disorder characterized by a necrotic process occurring in the hepatic parenchyma OR A necrotic process affecting the hepatic parenchyma. CCTO:000584 implies CCTO:000049 CCTO:000584 implies CCTO:001117 CCTO:000584(time_t t0) = EVENT_STATE(CCTO:000584, t0) NCI:CTCAE:10019692 NCIT:C57820 NCIT:C78340 UMLS:C0151798 UMLS:C1963135 Hepatic necrosis adverse event Hepatic necrotic lesion cancer_care_treatment_outcome CCTO:000584 Hepatic necrosis CCTO:000584 A disorder characterized by a necrotic process occurring in the hepatic parenchyma OR A necrotic process affecting the hepatic parenchyma. NCI:CTCAE NCIT:C78340 Hepatic necrosis adverse event NCIT:C57820 Hepatic necrotic lesion NCIT:C78340 A disorder characterized by a sensation of marked discomfort in the liver region OR A painful sensation in the liver. CCTO:000585 implies CCTO:000107 CCTO:000585 implies CCTO:001117 CCTO:000585(time_t t0) = EVENT_STATE(CCTO:000585, t0) NCI:CTCAE:10019705 NCIT:C78341 UMLS:C0522067 cancer_care_treatment_outcome CCTO:000585 Hepatic pain CCTO:000585 A disorder characterized by a sensation of marked discomfort in the liver region OR A painful sensation in the liver. NCI:CTCAE NCIT:C78341 A rupture in the wall of the extrahepatic or intrahepatic bile duct due to traumatic or pathologic processes OR A disorder characterized by a rupture in the wall of the extrahepatic or intrahepatic bile duct. CCTO:000586 implies CCTO:000049 CCTO:000586 implies CCTO:001117 CCTO:000586(time_t t0) = EVENT_STATE(CCTO:000586, t0) NCI:CTCAE:10034405 NCIT:C78528 UMLS:C0156218 Bile duct perforation cancer_care_treatment_outcome CCTO:000586 Perforation bile duct CCTO:000586 A rupture in the wall of the extrahepatic or intrahepatic bile duct due to traumatic or pathologic processes OR A disorder characterized by a rupture in the wall of the extrahepatic or intrahepatic bile duct. NCI:CTCAE NCIT:C78528 Bile duct perforation NCIT:C78528 Increased blood pressure in the portal venous system. It is most commonly caused by cirrhosis. Other causes include portal vein thrombosis, Budd-Chiari syndrome, and right heart failure. Complications include ascites, esophageal varices, encephalopathy, and splenomegaly OR A disorder characterized by an increase in blood pressure in the portal venous system. CCTO:000587 implies CCTO:000049 CCTO:000587 implies CCTO:001117 CCTO:000587(time_t t0) = EVENT_STATE(CCTO:000587, t0) NCI:CTCAE:10036200 NCIT:C3119 UMLS:C0020541 cancer_care_treatment_outcome CCTO:000587 Portal hypertension CCTO:000587 Increased blood pressure in the portal venous system. It is most commonly caused by cirrhosis. Other causes include portal vein thrombosis, Budd-Chiari syndrome, and right heart failure. Complications include ascites, esophageal varices, encephalopathy, and splenomegaly OR A disorder characterized by an increase in blood pressure in the portal venous system. NCI:CTCAE NCIT:C3119 The formation of a blood clot (thrombus) in the portal vein OR A disorder characterized by the formation of a thrombus (blood clot) in the portal vein. CCTO:000588 implies CCTO:000049 CCTO:000588 implies CCTO:001117 CCTO:000588(time_t t0) = EVENT_STATE(CCTO:000588, t0) NCI:CTCAE:10036206 NCIT:C78565 UMLS:C0155773 cancer_care_treatment_outcome CCTO:000588 Portal vein thrombosis CCTO:000588 The formation of a blood clot (thrombus) in the portal vein OR A disorder characterized by the formation of a thrombus (blood clot) in the portal vein. NCI:CTCAE NCIT:C78565 An immune response that occurs following re-exposure to an innocuous antigen, and that requires the presence of existing antibodies against that antigen. This response involves the binding of IgE to mast cells, and may worsen with repeated exposures OR A disorder characterized by an adverse local or general response from exposure to an allergen OR An immune response that occurs following exposure to an innocuous antigen, but that does not require the presence of preformed antibodies to the antigen. CCTO:000589 implies CCTO:000049 CCTO:000589 implies CCTO:001118 CCTO:000589(time_t t0) = EVENT_STATE(CCTO:000589, t0) NCI:CTCAE:10001718 NCIT:C114476 NCIT:C3114 UMLS:C0002111 UMLS:C0020517 UMLS:C0036667 UMLS:C0332324 UMLS:C1314973 UMLS:C1527304 UMLS:C1550474 UMLS:C1554743 UMLS:C2346484 UMLS:C2349185 Allergy Hypersensitive Hypersensitivity Hypersensitivity reaction Sensitive Sensitivity allergic response cancer_care_treatment_outcome CCTO:000589 Allergic reaction CCTO:000589 An immune response that occurs following re-exposure to an innocuous antigen, and that requires the presence of existing antibodies against that antigen. This response involves the binding of IgE to mast cells, and may worsen with repeated exposures OR A disorder characterized by an adverse local or general response from exposure to an allergen OR An immune response that occurs following exposure to an innocuous antigen, but that does not require the presence of preformed antibodies to the antigen. NCI:CTCAE NCIT:C114476 NCIT:C3114 Allergy NCIT:C114476 Hypersensitive NCIT:C3114 Hypersensitivity NCIT:C3114 Hypersensitivity reaction NCIT:C3114 Sensitive NCIT:C3114 Sensitivity NCIT:C3114 allergic response NCIT:C114476 Progression of anaphylaxis into systemic shock, which is characterized by significant reduction in tissue perfusion which leads to hypoxia and hypotension, and can lead to death if untreated OR An acute hypersensitive immune response that occurs from exposure to an allergen. It results from the release of histamine and histamine-like substances from mast cells, and can present with breathing difficulty due to narrowed airways, dizziness and hypotension, skin rash, weak pulse, nausea and vomiting OR A disorder characterized by an acute inflammatory reaction resulting from the release of histamine and histamine-like substances from mast cells, causing a hypersensitivity immune response. Clinically, it presents with breathing difficulty, dizziness, hypotension, cyanosis and loss of consciousness and may lead to death. CCTO:000590 implies CCTO:000049 CCTO:000590 implies CCTO:001118 CCTO:000590(time_t t0) = EVENT_STATE(CCTO:000590, t0) NCI:CTCAE:10002218 NCIT:C107101 NCIT:C50460 UMLS:C0002792 Anaphylactic shock Shock, anaphylactic cancer_care_treatment_outcome CCTO:000590 Anaphylaxis CCTO:000590 Progression of anaphylaxis into systemic shock, which is characterized by significant reduction in tissue perfusion which leads to hypoxia and hypotension, and can lead to death if untreated OR An acute hypersensitive immune response that occurs from exposure to an allergen. It results from the release of histamine and histamine-like substances from mast cells, and can present with breathing difficulty due to narrowed airways, dizziness and hypotension, skin rash, weak pulse, nausea and vomiting OR A disorder characterized by an acute inflammatory reaction resulting from the release of histamine and histamine-like substances from mast cells, causing a hypersensitivity immune response. Clinically, it presents with breathing difficulty, dizziness, hypotension, cyanosis and loss of consciousness and may lead to death. NCI:CTCAE NCIT:C107101 NCIT:C50460 Anaphylactic shock NCIT:C50460 Shock, anaphylactic NCIT:C50460 A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to his own tissue constituents. It may be systemic (e.g., systemic lupus erythematosus), or organ specific, (e.g., thyroiditis) OR A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to his own tissue constituents. CCTO:000591 implies CCTO:000049 CCTO:000591 implies CCTO:001118 CCTO:000591(time_t t0) = EVENT_STATE(CCTO:000591, t0) NCI:CTCAE:10061664 NCIT:C2889 UMLS:C0004364 Autoimmune disease Disease, autoimmune cancer_care_treatment_outcome CCTO:000591 Autoimmune disorder CCTO:000591 A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to his own tissue constituents. It may be systemic (e.g., systemic lupus erythematosus), or organ specific, (e.g., thyroiditis) OR A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to his own tissue constituents. NCI:CTCAE NCIT:C2889 Autoimmune disease NCIT:C2889 Disease, autoimmune NCIT:C2889 A syndrome that occurs after therapeutic infusion of antibodies into the blood and is characterized by nausea, headache, tachycardia, hypotension, rash, and shortness of breath. It is caused by the release of cytokines from the cells that are targeted by the antibodies. Most patients experience a mild to moderate reaction; however, the reaction may be severe and life-threatening OR A disorder characterized by nausea, headache, tachycardia, hypotension, rash, and shortness of breath; it is caused by the release of cytokines from the cells. CCTO:000592 implies CCTO:000049 CCTO:000592 implies CCTO:001118 CCTO:000592(time_t t0) = EVENT_STATE(CCTO:000592, t0) NCI:CTCAE:10052015 NCIT:C78251 UMLS:C0948245 cancer_care_treatment_outcome CCTO:000592 Cytokine release syndrome CCTO:000592 A syndrome that occurs after therapeutic infusion of antibodies into the blood and is characterized by nausea, headache, tachycardia, hypotension, rash, and shortness of breath. It is caused by the release of cytokines from the cells that are targeted by the antibodies. Most patients experience a mild to moderate reaction; however, the reaction may be severe and life-threatening OR A disorder characterized by nausea, headache, tachycardia, hypotension, rash, and shortness of breath; it is caused by the release of cytokines from the cells. NCI:CTCAE NCIT:C78251 Delayed-type hypersensitivity reaction to foreign proteins derived from an animal serum. It occurs approximately six to twenty one days following the administration of the foreign antigen. Symptoms include fever, arthralgias, myalgias, skin eruptions, lymphadenopathy, chest pain, and dyspnea. Certain drugs (e.g., antibiotics, anticancer agents, and anti-inflammatory medications) and infectious disorders (e.g., hepatitis B) may also cause serum sickness-like reaction OR A disorder characterized by a delayed-type hypersensitivity reaction to foreign proteins derived from an animal serum. It occurs approximately six to twenty-one days following the administration of the foreign antigen. Symptoms include fever, arthralgias, myalgias, skin eruptions, lymphadenopathy, chest marked discomfort and dyspnea. CCTO:000593 implies CCTO:000049 CCTO:000593 implies CCTO:001118 CCTO:000593(time_t t0) = EVENT_STATE(CCTO:000593, t0) NCI:CTCAE:10040400 NCIT:C54740 NCIT:C79718 UMLS:C0036830 UMLS:C1963234 Serum sickness adverse event cancer_care_treatment_outcome CCTO:000593 Serum sickness CCTO:000593 Delayed-type hypersensitivity reaction to foreign proteins derived from an animal serum. It occurs approximately six to twenty one days following the administration of the foreign antigen. Symptoms include fever, arthralgias, myalgias, skin eruptions, lymphadenopathy, chest pain, and dyspnea. Certain drugs (e.g., antibiotics, anticancer agents, and anti-inflammatory medications) and infectious disorders (e.g., hepatitis B) may also cause serum sickness-like reaction OR A disorder characterized by a delayed-type hypersensitivity reaction to foreign proteins derived from an animal serum. It occurs approximately six to twenty-one days following the administration of the foreign antigen. Symptoms include fever, arthralgias, myalgias, skin eruptions, lymphadenopathy, chest marked discomfort and dyspnea. NCI:CTCAE NCIT:C79718 Serum sickness adverse event NCIT:C54740 Infection in the abdominal cavity resulting from injury, acute intestinal inflammation (e.g., acute appendicitis), intestinal perforation, or complication of abdominal surgery OR A disorder characterized by an infectious process involving the abdominal cavity. CCTO:000594 implies CCTO:000049 CCTO:000594 implies CCTO:001119 CCTO:000594(time_t t0) = EVENT_STATE(CCTO:000594, t0) NCI:CTCAE:10056519 NCIT:C35669 UMLS:C1112209 cancer_care_treatment_outcome CCTO:000594 Abdominal infection CCTO:000594 Infection in the abdominal cavity resulting from injury, acute intestinal inflammation (e.g., acute appendicitis), intestinal perforation, or complication of abdominal surgery OR A disorder characterized by an infectious process involving the abdominal cavity. NCI:CTCAE NCIT:C35669 A disorder characterized by an infectious process involving the anal area and the rectum OR An infectious process affecting the anal area and the rectum. CCTO:000595 implies CCTO:000049 CCTO:000595 implies CCTO:001119 CCTO:000595(time_t t0) = EVENT_STATE(CCTO:000595, t0) NCI:CTCAE:10061640 NCIT:C78174 UMLS:C2700620 cancer_care_treatment_outcome CCTO:000595 Anorectal infection CCTO:000595 A disorder characterized by an infectious process involving the anal area and the rectum OR An infectious process affecting the anal area and the rectum. NCI:CTCAE NCIT:C78174 A disorder characterized by acute inflammation to the vermiform appendix caused by a pathogenic agent OR Acute inflammation of the vermiform appendix. CCTO:000596 implies CCTO:000049 CCTO:000596 implies CCTO:001119 CCTO:000596(time_t t0) = EVENT_STATE(CCTO:000596, t0) NCI:CTCAE:10003011 NCIT:C35145 UMLS:C0003615 UMLS:C0085693 Acute appendicitis cancer_care_treatment_outcome CCTO:000596 Appendicitis CCTO:000596 A disorder characterized by acute inflammation to the vermiform appendix caused by a pathogenic agent OR Acute inflammation of the vermiform appendix. NCI:CTCAE NCIT:C35145 Acute appendicitis NCIT:C35145 Acute appendicitis with gangrenous changes resulting in the rupture of the appendiceal wall. The appendiceal wall rupture causes the release of inflammatory and bacterial contents from the appendiceal lumen into the abdominal cavity OR A disorder characterized by acute inflammation to the vermiform appendix caused by a pathogenic agent with gangrenous changes resulting in the rupture of the appendiceal wall. The appendiceal wall rupture causes the release of inflammatory and bacterial contents from the appendiceal lumen into the abdominal cavity. CCTO:000597 implies CCTO:000049 CCTO:000597 implies CCTO:001119 CCTO:000597(time_t t0) = EVENT_STATE(CCTO:000597, t0) NCI:CTCAE:10003012 NCIT:C78178 UMLS:C0564755 UMLS:C0854119 Acute perforated appendicitis cancer_care_treatment_outcome CCTO:000597 Appendicitis perforated CCTO:000597 Acute appendicitis with gangrenous changes resulting in the rupture of the appendiceal wall. The appendiceal wall rupture causes the release of inflammatory and bacterial contents from the appendiceal lumen into the abdominal cavity OR A disorder characterized by acute inflammation to the vermiform appendix caused by a pathogenic agent with gangrenous changes resulting in the rupture of the appendiceal wall. The appendiceal wall rupture causes the release of inflammatory and bacterial contents from the appendiceal lumen into the abdominal cavity. NCI:CTCAE NCIT:C78178 Acute perforated appendicitis NCIT:C78178 A disorder characterized by an infectious process involving an artery OR A bacterial or viral infectious process affecting an artery. CCTO:000598 implies CCTO:000049 CCTO:000598 implies CCTO:001119 CCTO:000598(time_t t0) = EVENT_STATE(CCTO:000598, t0) NCI:CTCAE:10065744 NCIT:C83506 UMLS:C1697748 Infectious arteritis cancer_care_treatment_outcome CCTO:000598 Arteritis infective CCTO:000598 A disorder characterized by an infectious process involving an artery OR A bacterial or viral infectious process affecting an artery. NCI:CTCAE NCIT:C83506 Infectious arteritis NCIT:C83506 A disorder characterized by an infectious process involving the biliary tract OR An acute or chronic inflammatory process affecting the biliary tract. CCTO:000599 implies CCTO:000049 CCTO:000599 implies CCTO:001119 CCTO:000599(time_t t0) = EVENT_STATE(CCTO:000599, t0) NCI:CTCAE:10061695 NCIT:C26718 UMLS:C0008311 UMLS:C0920156 Cholangitis cancer_care_treatment_outcome CCTO:000599 Biliary tract infection CCTO:000599 A disorder characterized by an infectious process involving the biliary tract OR An acute or chronic inflammatory process affecting the biliary tract. NCI:CTCAE NCIT:C26718 Cholangitis NCIT:C26718 An infectious process affecting the urinary bladder OR A disorder characterized by an infectious process involving the bladder OR Inflammation of the urinary bladder. CCTO:000600 implies CCTO:000049 CCTO:000600 implies CCTO:001119 CCTO:000600(time_t t0) = EVENT_STATE(CCTO:000600, t0) NCI:CTCAE:10005047 NCIT:C26738 NCIT:C83816 UMLS:C0010692 UMLS:C0600041 Cystitis Infectious cystitis cancer_care_treatment_outcome CCTO:000600 Bladder infection CCTO:000600 An infectious process affecting the urinary bladder OR A disorder characterized by an infectious process involving the bladder OR Inflammation of the urinary bladder. NCI:CTCAE NCIT:C26738 NCIT:C83816 Cystitis NCIT:C26738 Infectious cystitis NCIT:C83816 A disorder characterized by an infectious process involving the bones OR An acute or chronic infectious process affecting the bones. CCTO:000601 implies CCTO:000049 CCTO:000601 implies CCTO:001119 CCTO:000601(time_t t0) = EVENT_STATE(CCTO:000601, t0) NCI:CTCAE:10061017 NCIT:C26839 UMLS:C2242472 cancer_care_treatment_outcome CCTO:000601 Bone infection CCTO:000601 A disorder characterized by an infectious process involving the bones OR An acute or chronic infectious process affecting the bones. NCI:CTCAE NCIT:C26839 A disorder characterized by an infectious process involving the breast OR Inflammation of breast tissue during lactation or postpartum due to an obstructed duct or infection. CCTO:000602 implies CCTO:000049 CCTO:000602 implies CCTO:001119 CCTO:000602(time_t t0) = EVENT_STATE(CCTO:000602, t0) NCI:CTCAE:10006259 NCIT:C53662 UMLS:C0024894 UMLS:C0392317 UMLS:C3251795 Mastitis cancer_care_treatment_outcome CCTO:000602 Breast infection CCTO:000602 A disorder characterized by an infectious process involving the breast OR Inflammation of breast tissue during lactation or postpartum due to an obstructed duct or infection. NCI:CTCAE NCIT:C53662 Mastitis NCIT:C53662 A disorder characterized by an infectious process involving the bronchi OR An acute or chronic inflammatory process affecting the bronchi. CCTO:000603 implies CCTO:000049 CCTO:000603 implies CCTO:001119 CCTO:000603(time_t t0) = EVENT_STATE(CCTO:000603, t0) NCI:CTCAE:10055078 NCIT:C2911 UMLS:C0006277 UMLS:C0340238 Bronchitis cancer_care_treatment_outcome CCTO:000603 Bronchial infection CCTO:000603 A disorder characterized by an infectious process involving the bronchi OR An acute or chronic inflammatory process affecting the bronchi. NCI:CTCAE NCIT:C2911 Bronchitis NCIT:C2911 A disorder characterized by an infectious process that arises secondary to catheter use OR An infection that arises secondary to catheter use. CCTO:000604 implies CCTO:000049 CCTO:000604 implies CCTO:001119 CCTO:000604(time_t t0) = EVENT_STATE(CCTO:000604, t0) NCI:CTCAE:10007810 NCIT:C78232 UMLS:C0860239 Catheter-related infection cancer_care_treatment_outcome CCTO:000604 Catheter related infection CCTO:000604 A disorder characterized by an infectious process that arises secondary to catheter use OR An infection that arises secondary to catheter use. NCI:CTCAE NCIT:C78232 Catheter-related infection NCIT:C78232 An infectious process affecting the cecum OR A disorder characterized by an infectious process involving the cecum. CCTO:000605 implies CCTO:000049 CCTO:000605 implies CCTO:001119 CCTO:000605(time_t t0) = EVENT_STATE(CCTO:000605, t0) NCI:CTCAE:10065761 NCIT:C78235 UMLS:C1699694 cancer_care_treatment_outcome CCTO:000605 Cecal infection CCTO:000605 An infectious process affecting the cecum OR A disorder characterized by an infectious process involving the cecum. NCI:CTCAE NCIT:C78235 A disorder characterized by an infectious process involving the uterine cervix OR An infectious process affecting the uterine cervix. Causative agents include Neisseria gonorrhoeae, Chlamydia trachomatis, human papillomavirus, and herpes simplex virus. Physical examination reveals an erythematous, raised lesion in the cervix and mucopurulent discharge. CCTO:000606 implies CCTO:000049 CCTO:000606 implies CCTO:001119 CCTO:000606(time_t t0) = EVENT_STATE(CCTO:000606, t0) NCI:CTCAE:10008330 NCIT:C78360 UMLS:C0856203 Infectious cervicitis cancer_care_treatment_outcome CCTO:000606 Cervicitis infection CCTO:000606 A disorder characterized by an infectious process involving the uterine cervix OR An infectious process affecting the uterine cervix. Causative agents include Neisseria gonorrhoeae, Chlamydia trachomatis, human papillomavirus, and herpes simplex virus. Physical examination reveals an erythematous, raised lesion in the cervix and mucopurulent discharge. NCI:CTCAE NCIT:C78360 Infectious cervicitis NCIT:C78360 An infectious process affecting the conjunctiva OR Acute inflammation of the conjunctiva characterized by pink or red color in the eyes OR A disorder characterized by an infectious process involving the conjunctiva. Clinical manifestations include pink or red color in the eyes. CCTO:000607 implies CCTO:000049 CCTO:000607 implies CCTO:001119 CCTO:000607(time_t t0) = EVENT_STATE(CCTO:000607, t0) NCI:CTCAE:10010742 NCIT:C35704 NCIT:C83508 UMLS:C0497209 UMLS:C1313983 Acute contagious conjunctivitis Infectious conjunctivitis Pinkeye cancer_care_treatment_outcome CCTO:000607 Conjunctivitis infective CCTO:000607 An infectious process affecting the conjunctiva OR Acute inflammation of the conjunctiva characterized by pink or red color in the eyes OR A disorder characterized by an infectious process involving the conjunctiva. Clinical manifestations include pink or red color in the eyes. NCI:CTCAE NCIT:C35704 NCIT:C83508 Acute contagious conjunctivitis NCIT:C35704 Infectious conjunctivitis NCIT:C83508 Pinkeye NCIT:C35704 A viral or bacterial infectious process affecting the cornea. Symptoms include pain and redness in the eye, photophobia and eye watering OR A disorder characterized by an infectious process involving the cornea. CCTO:000608 implies CCTO:000049 CCTO:000608 implies CCTO:001119 CCTO:000608(time_t t0) = EVENT_STATE(CCTO:000608, t0) NCI:CTCAE:10061788 NCIT:C83813 UMLS:C0729777 cancer_care_treatment_outcome CCTO:000608 Corneal infection CCTO:000608 A viral or bacterial infectious process affecting the cornea. Symptoms include pain and redness in the eye, photophobia and eye watering OR A disorder characterized by an infectious process involving the cornea. NCI:CTCAE NCIT:C83813 An infectious process affecting a cranial nerve OR A disorder characterized by an infectious process involving a cranial nerve. CCTO:000609 implies CCTO:000049 CCTO:000609 implies CCTO:001119 CCTO:000609(time_t t0) = EVENT_STATE(CCTO:000609, t0) NCI:CTCAE:10065765 NCIT:C78248 UMLS:C1697749 cancer_care_treatment_outcome CCTO:000609 Cranial nerve infection CCTO:000609 An infectious process affecting a cranial nerve OR A disorder characterized by an infectious process involving a cranial nerve. NCI:CTCAE NCIT:C78248 An infectious disorder caused by the use of a medical device OR A disorder characterized by an infectious process involving the use of a medical device OR A bacterial infection related to a device used to replace a missing body part. The infection may occur during the operation from direct contamination or post-operatively through hematogenous spread. CCTO:000610 implies CCTO:000049 CCTO:000610 implies CCTO:001119 CCTO:000610(time_t t0) = EVENT_STATE(CCTO:000610, t0) NCI:CTCAE:10064687 NCIT:C78255 NCIT:C79705 UMLS:C0085073 UMLS:C1619702 Device-related infection Prosthesis-related infection cancer_care_treatment_outcome CCTO:000610 Device related infection CCTO:000610 An infectious disorder caused by the use of a medical device OR A disorder characterized by an infectious process involving the use of a medical device OR A bacterial infection related to a device used to replace a missing body part. The infection may occur during the operation from direct contamination or post-operatively through hematogenous spread. NCI:CTCAE NCIT:C78255 NCIT:C79705 Device-related infection NCIT:C78255 Prosthesis-related infection NCIT:C79705 An infectious process affecting the duodenum OR A disorder characterized by an infectious process involving the duodenum. CCTO:000611 implies CCTO:000049 CCTO:000611 implies CCTO:001119 CCTO:000611(time_t t0) = EVENT_STATE(CCTO:000611, t0) NCI:CTCAE:10065752 NCIT:C78258 UMLS:C1698629 cancer_care_treatment_outcome CCTO:000611 Duodenal infection CCTO:000611 An infectious process affecting the duodenum OR A disorder characterized by an infectious process involving the duodenum. NCI:CTCAE NCIT:C78258 An acute infectious process that affects the brain tissue. It is usually caused by viruses and less often by bacteria, parasites, and fungi OR A disorder characterized by an infectious process involving the brain tissue. CCTO:000612 implies CCTO:000049 CCTO:000612 implies CCTO:001119 CCTO:000612(time_t t0) = EVENT_STATE(CCTO:000612, t0) NCI:CTCAE:10014594 NCIT:C79550 UMLS:C0596773 Infectious encephalitis cancer_care_treatment_outcome CCTO:000612 Encephalitis infection CCTO:000612 An acute infectious process that affects the brain tissue. It is usually caused by viruses and less often by bacteria, parasites, and fungi OR A disorder characterized by an infectious process involving the brain tissue. NCI:CTCAE NCIT:C79550 Infectious encephalitis NCIT:C79550 A disorder characterized by an infectious process involving the brain and spinal cord tissues OR An infectious process that affects the brain and spinal cord tissues. It is usually caused by viruses. CCTO:000613 implies CCTO:000049 CCTO:000613 implies CCTO:001119 CCTO:000613(time_t t0) = EVENT_STATE(CCTO:000613, t0) NCI:CTCAE:10014621 NCIT:C79551 UMLS:C0856705 Infectious encephalomyelitis cancer_care_treatment_outcome CCTO:000613 Encephalomyelitis infection CCTO:000613 A disorder characterized by an infectious process involving the brain and spinal cord tissues OR An infectious process that affects the brain and spinal cord tissues. It is usually caused by viruses. NCI:CTCAE NCIT:C79551 Infectious encephalomyelitis NCIT:C79551 A disorder characterized by an infectious process involving the endocardial layer of the heart OR An infectious process involving the endocardial layer of the heart. CCTO:000614 implies CCTO:000049 CCTO:000614 implies CCTO:001119 CCTO:000614(time_t t0) = EVENT_STATE(CCTO:000614, t0) NCI:CTCAE:10014678 NCIT:C78265 UMLS:C0014121 UMLS:C1541923 Infective endocarditis cancer_care_treatment_outcome CCTO:000614 Endocarditis infective CCTO:000614 A disorder characterized by an infectious process involving the endocardial layer of the heart OR An infectious process involving the endocardial layer of the heart. NCI:CTCAE NCIT:C78265 Infective endocarditis NCIT:C78265 An infectious process affecting the internal structures of the eye OR A disorder characterized by an infectious process involving the internal structures of the eye. CCTO:000615 implies CCTO:000049 CCTO:000615 implies CCTO:001119 CCTO:000615(time_t t0) = EVENT_STATE(CCTO:000615, t0) NCI:CTCAE:10014801 NCIT:C34586 UMLS:C0014236 cancer_care_treatment_outcome CCTO:000615 Endophthalmitis CCTO:000615 An infectious process affecting the internal structures of the eye OR A disorder characterized by an infectious process involving the internal structures of the eye. NCI:CTCAE NCIT:C34586 A disorder characterized by an infectious process involving the small and large intestines OR An infectious process affecting the small and large intestines. Symptoms include diarrhea, cramping abdominal pain, and fever. CCTO:000616 implies CCTO:000049 CCTO:000616 implies CCTO:001119 CCTO:000616(time_t t0) = EVENT_STATE(CCTO:000616, t0) NCI:CTCAE:10058838 NCIT:C80513 UMLS:C1142115 Infectious enterocolitis cancer_care_treatment_outcome CCTO:000616 Enterocolitis infectious CCTO:000616 A disorder characterized by an infectious process involving the small and large intestines OR An infectious process affecting the small and large intestines. Symptoms include diarrhea, cramping abdominal pain, and fever. NCI:CTCAE NCIT:C80513 Infectious enterocolitis NCIT:C80513 A disorder characterized by an infectious process involving the esophagus OR An infectious process affecting the esophagus. CCTO:000617 implies CCTO:000049 CCTO:000617 implies CCTO:001119 CCTO:000617(time_t t0) = EVENT_STATE(CCTO:000617, t0) NCI:CTCAE:10058804 NCIT:C78277 UMLS:C0851979 cancer_care_treatment_outcome CCTO:000617 Esophageal infection CCTO:000617 A disorder characterized by an infectious process involving the esophagus OR An infectious process affecting the esophagus. NCI:CTCAE NCIT:C78277 An infectious process affecting any part of the eye. Causes include viruses and bacteria. Symptoms include itching and discomfort in the eye, watery eyes, eye pain and discharge, and blurring vision. Representative examples include pink eye, blepharitis, and trachoma OR A disorder characterized by an infectious process involving the eye. CCTO:000618 implies CCTO:000049 CCTO:000618 implies CCTO:001119 CCTO:000618(time_t t0) = EVENT_STATE(CCTO:000618, t0) NCI:CTCAE:10015929 NCIT:C45372 UMLS:C0015403 cancer_care_treatment_outcome CCTO:000618 Eye infection CCTO:000618 An infectious process affecting any part of the eye. Causes include viruses and bacteria. Symptoms include itching and discomfort in the eye, watery eyes, eye pain and discharge, and blurring vision. Representative examples include pink eye, blepharitis, and trachoma OR A disorder characterized by an infectious process involving the eye. NCI:CTCAE NCIT:C45372 An acute or chronic infectious process affecting the gallbladder OR A disorder characterized by an infectious process involving the gallbladder. CCTO:000619 implies CCTO:000049 CCTO:000619 implies CCTO:001119 CCTO:000619(time_t t0) = EVENT_STATE(CCTO:000619, t0) NCI:CTCAE:10062632 NCIT:C78306 UMLS:C0744254 cancer_care_treatment_outcome CCTO:000619 Gallbladder infection CCTO:000619 An acute or chronic infectious process affecting the gallbladder OR A disorder characterized by an infectious process involving the gallbladder. NCI:CTCAE NCIT:C78306 A disorder characterized by an infectious process involving the gums OR An acute or chronic infectious process affecting the gums. CCTO:000620 implies CCTO:000049 CCTO:000620 implies CCTO:001119 CCTO:000620(time_t t0) = EVENT_STATE(CCTO:000620, t0) NCI:CTCAE:10018784 NCIT:C78329 UMLS:C0744403 cancer_care_treatment_outcome CCTO:000620 Gum infection CCTO:000620 A disorder characterized by an infectious process involving the gums OR An acute or chronic infectious process affecting the gums. NCI:CTCAE NCIT:C78329 An acute or chronic infectious process affecting the liver OR A disorder characterized by an infectious process involving the liver. CCTO:000621 implies CCTO:000049 CCTO:000621 implies CCTO:001119 CCTO:000621(time_t t0) = EVENT_STATE(CCTO:000621, t0) NCI:CTCAE:10056522 NCIT:C78339 UMLS:C1112211 cancer_care_treatment_outcome CCTO:000621 Hepatic infection CCTO:000621 An acute or chronic infectious process affecting the liver OR A disorder characterized by an infectious process involving the liver. NCI:CTCAE NCIT:C78339 An acute or chronic inflammation of the liver parenchyma caused by viruses. Representative examples include hepatitis A, B, and C, cytomegalovirus hepatitis, and herpes simplex hepatitis OR A disorder characterized by a viral pathologic process involving the liver parenchyma. CCTO:000622 implies CCTO:000049 CCTO:000622 implies CCTO:001119 CCTO:000622(time_t t0) = EVENT_STATE(CCTO:000622, t0) NCI:CTCAE:10019799 NCIT:C35124 UMLS:C0042721 Viral hepatitis cancer_care_treatment_outcome CCTO:000622 Hepatitis viral CCTO:000622 An acute or chronic inflammation of the liver parenchyma caused by viruses. Representative examples include hepatitis A, B, and C, cytomegalovirus hepatitis, and herpes simplex hepatitis OR A disorder characterized by a viral pathologic process involving the liver parenchyma. NCI:CTCAE NCIT:C35124 Viral hepatitis NCIT:C35124 A disorder characterized by an infectious process involving the skeletal muscles OR An infectious process affecting the skeletal muscles. It can be caused by viruses (including HIV), bacteria, fungi, and parasites. Symptoms include muscle weakness and muscle pain. CCTO:000623 implies CCTO:000049 CCTO:000623 implies CCTO:001119 CCTO:000623(time_t t0) = EVENT_STATE(CCTO:000623, t0) NCI:CTCAE:10021918 NCIT:C26984 UMLS:C0158353 Infectious myositis cancer_care_treatment_outcome CCTO:000623 Infective myositis CCTO:000623 A disorder characterized by an infectious process involving the skeletal muscles OR An infectious process affecting the skeletal muscles. It can be caused by viruses (including HIV), bacteria, fungi, and parasites. Symptoms include muscle weakness and muscle pain. NCI:CTCAE NCIT:C26984 Infectious myositis NCIT:C26984 A disorder characterized by an infectious process involving a joint OR An infectious process affecting a joint. Causative agents include bacteria, viruses, fungi, and parasites. CCTO:000624 implies CCTO:000049 CCTO:000624 implies CCTO:001119 CCTO:000624(time_t t0) = EVENT_STATE(CCTO:000624, t0) NCI:CTCAE:10023216 NCIT:C78402 UMLS:C0157749 cancer_care_treatment_outcome CCTO:000624 Joint infection CCTO:000624 A disorder characterized by an infectious process involving a joint OR An infectious process affecting a joint. Causative agents include bacteria, viruses, fungi, and parasites. NCI:CTCAE NCIT:C78402 A disorder characterized by an infectious process involving the kidney OR An acute or chronic inflammatory process affecting the kidney. It is caused by bacteria and in most cases it is the result of a urinary tract infection. Signs and symptoms include fever, chills, flank pain, painful and frequent urination, cloudy or bloody urine, and confusion OR An inflammatory process affecting the kidney. The cause is most often bacterial, but may also be fungal in nature. Signs and symptoms may include fever, chills, flank pain, painful and frequent urination, cloudy or bloody urine, and confusion. CCTO:000625 implies CCTO:000049 CCTO:000625 implies CCTO:001119 CCTO:000625(time_t t0) = EVENT_STATE(CCTO:000625, t0) NCI:CTCAE:10023424 NCIT:C34965 NCIT:C79604 UMLS:C0021313 UMLS:C0034186 Pyelonephritis cancer_care_treatment_outcome CCTO:000625 Kidney infection CCTO:000625 A disorder characterized by an infectious process involving the kidney OR An acute or chronic inflammatory process affecting the kidney. It is caused by bacteria and in most cases it is the result of a urinary tract infection. Signs and symptoms include fever, chills, flank pain, painful and frequent urination, cloudy or bloody urine, and confusion OR An inflammatory process affecting the kidney. The cause is most often bacterial, but may also be fungal in nature. Signs and symptoms may include fever, chills, flank pain, painful and frequent urination, cloudy or bloody urine, and confusion. NCI:CTCAE NCIT:C34965 NCIT:C79604 Pyelonephritis NCIT:C34965 Pyelonephritis NCIT:C79604 An acute or chronic, bacterial or viral inflammatory process affecting the larynx. Signs and symptoms include sore throat, cough, swallowing difficulties, and hoarseness OR A disorder characterized by an inflammatory process involving the larynx OR An acute inflammatory process affecting the larynx. It is caused by bacteria, viruses, or vocal strain. Signs and symptoms include sore throat, cough, swallowing difficulties, and hoarseness. CCTO:000626 implies CCTO:000049 CCTO:000626 implies CCTO:001119 CCTO:000626 implies CCTO:001127 CCTO:000626(time_t t0) = EVENT_STATE(CCTO:000626, t0) NCI:CTCAE:10023874 NCI:CTCAE:10065735 NCIT:C26688 NCIT:C26811 UMLS:C0001327 UMLS:C0023067 Acute laryngitis Laryngeal inflammation cancer_care_treatment_outcome CCTO:000626 Laryngitis CCTO:000626 An acute or chronic, bacterial or viral inflammatory process affecting the larynx. Signs and symptoms include sore throat, cough, swallowing difficulties, and hoarseness OR A disorder characterized by an inflammatory process involving the larynx OR An acute inflammatory process affecting the larynx. It is caused by bacteria, viruses, or vocal strain. Signs and symptoms include sore throat, cough, swallowing difficulties, and hoarseness. NCI:CTCAE NCIT:C26688 NCIT:C26811 Acute laryngitis NCIT:C26688 Laryngeal inflammation NCIT:C26811 An acute or chronic infectious process affecting the lips OR A disorder characterized by an infectious process involving the lips. CCTO:000627 implies CCTO:000049 CCTO:000627 implies CCTO:001119 CCTO:000627(time_t t0) = EVENT_STATE(CCTO:000627, t0) NCI:CTCAE:10065755 NCIT:C78434 UMLS:C1698666 cancer_care_treatment_outcome CCTO:000627 Lip infection CCTO:000627 An acute or chronic infectious process affecting the lips OR A disorder characterized by an infectious process involving the lips. NCI:CTCAE NCIT:C78434 An acute or chronic infectious process affecting the lungs OR A disorder characterized by an infectious process involving the lungs. CCTO:000628 implies CCTO:000049 CCTO:000628 implies CCTO:001119 CCTO:000628(time_t t0) = EVENT_STATE(CCTO:000628, t0) NCI:CTCAE:10061229 NCIT:C26873 UMLS:C0876973 Infectious lung disease Infectious lung diseases Infectious lung disorder Infectious lung disorders cancer_care_treatment_outcome CCTO:000628 Lung infection CCTO:000628 An acute or chronic infectious process affecting the lungs OR A disorder characterized by an infectious process involving the lungs. NCI:CTCAE NCIT:C26873 Infectious lung disease NCIT:C26873 Infectious lung diseases NCIT:C26873 Infectious lung disorder NCIT:C26873 Infectious lung disorders NCIT:C26873 A disorder characterized by an infectious process involving the lymph nodes OR Acute or chronic inflammation of one or more lymph nodes. It is usually caused by an infectious process. CCTO:000629 implies CCTO:000049 CCTO:000629 implies CCTO:001119 CCTO:000629(time_t t0) = EVENT_STATE(CCTO:000629, t0) NCI:CTCAE:10050823 NCIT:C26821 UMLS:C0001416 UMLS:C0024205 Adenitis Lymphadenitis cancer_care_treatment_outcome CCTO:000629 Lymph gland infection CCTO:000629 A disorder characterized by an infectious process involving the lymph nodes OR Acute or chronic inflammation of one or more lymph nodes. It is usually caused by an infectious process. NCI:CTCAE NCIT:C26821 Adenitis NCIT:C26821 Lymphadenitis NCIT:C26821 A disorder characterized by an infectious process involving the mediastinum OR An acute or chronic infectious process affecting the mediastinum. CCTO:000630 implies CCTO:000049 CCTO:000630 implies CCTO:001119 CCTO:000630(time_t t0) = EVENT_STATE(CCTO:000630, t0) NCI:CTCAE:10057483 NCIT:C83815 UMLS:C0729554 Infectious mediastinitis cancer_care_treatment_outcome CCTO:000630 Mediastinal infection CCTO:000630 A disorder characterized by an infectious process involving the mediastinum OR An acute or chronic infectious process affecting the mediastinum. NCI:CTCAE NCIT:C83815 Infectious mediastinitis NCIT:C83815 A disorder characterized by acute inflammation of the meninges of the brain and/or spinal cord OR A disorder characterized by acute inflammation of the meninges of the brain and/or spinal cord. CCTO:000631 implies CCTO:000049 CCTO:000631 implies CCTO:001119 CCTO:000631(time_t t0) = EVENT_STATE(CCTO:000631, t0) NCI:CTCAE:10027199 NCIT:C26828 UMLS:C0025289 UMLS:C0497299 cancer_care_treatment_outcome CCTO:000631 Meningitis CCTO:000631 A disorder characterized by acute inflammation of the meninges of the brain and/or spinal cord OR A disorder characterized by acute inflammation of the meninges of the brain and/or spinal cord. NCI:CTCAE NCIT:C26828 A disorder characterized by an infectious process involving a mucosal surface OR An acute or chronic infectious process affecting a mucosal surface. CCTO:000632 implies CCTO:000049 CCTO:000632 implies CCTO:001119 CCTO:000632(time_t t0) = EVENT_STATE(CCTO:000632, t0) NCI:CTCAE:10065764 NCIT:C78454 UMLS:C1698484 cancer_care_treatment_outcome CCTO:000632 Mucosal infection CCTO:000632 A disorder characterized by an infectious process involving a mucosal surface OR An acute or chronic infectious process affecting a mucosal surface. NCI:CTCAE NCIT:C78454 An infectious process affecting the nail OR A disorder characterized by an infectious process involving the nail. CCTO:000633 implies CCTO:000049 CCTO:000633 implies CCTO:001119 CCTO:000633(time_t t0) = EVENT_STATE(CCTO:000633, t0) NCI:CTCAE:10061304 NCIT:C78493 UMLS:C0343026 cancer_care_treatment_outcome CCTO:000633 Nail infection CCTO:000633 An infectious process affecting the nail OR A disorder characterized by an infectious process involving the nail. NCI:CTCAE NCIT:C78493 An infectious process affecting the ovary OR A disorder characterized by an infectious process involving the ovary. CCTO:000634 implies CCTO:000049 CCTO:000634 implies CCTO:001119 CCTO:000634(time_t t0) = EVENT_STATE(CCTO:000634, t0) NCI:CTCAE:10055005 NCIT:C78512 UMLS:C0349735 cancer_care_treatment_outcome CCTO:000634 Ovarian infection CCTO:000634 An infectious process affecting the ovary OR A disorder characterized by an infectious process involving the ovary. NCI:CTCAE NCIT:C78512 An infectious process affecting the pancreas OR A disorder characterized by an infectious process involving the pancreas. CCTO:000635 implies CCTO:000049 CCTO:000635 implies CCTO:001119 CCTO:000635(time_t t0) = EVENT_STATE(CCTO:000635, t0) NCI:CTCAE:10051741 NCIT:C78517 UMLS:C0948160 Pancreatic infection cancer_care_treatment_outcome CCTO:000635 Pancreas infection CCTO:000635 An infectious process affecting the pancreas OR A disorder characterized by an infectious process involving the pancreas. NCI:CTCAE NCIT:C78517 Pancreatic infection NCIT:C78517 Skin eruption consisting of papules and pustules, most often appearing in the face, scalp, and upper trunk. It is usually caused by corticosteroids or epidermal growth factor receptor inhibitors OR A disorder characterized by an eruption consisting of papules (a small, raised pimple) and pustules (a small pus filled blister), typically appearing in face, scalp, and upper chest and back Unlike acne, this rash does not present with whiteheads or blackheads, and can be symptomatic, with itchy or tender lesions. CCTO:000636 implies CCTO:000049 CCTO:000636 implies CCTO:001119 CCTO:000636(time_t t0) = EVENT_STATE(CCTO:000636, t0) NCI:CTCAE:10069138 NCIT:C80119 UMLS:C2609319 cancer_care_treatment_outcome CCTO:000636 Papulopustular rash CCTO:000636 Skin eruption consisting of papules and pustules, most often appearing in the face, scalp, and upper trunk. It is usually caused by corticosteroids or epidermal growth factor receptor inhibitors OR A disorder characterized by an eruption consisting of papules (a small, raised pimple) and pustules (a small pus filled blister), typically appearing in face, scalp, and upper chest and back Unlike acne, this rash does not present with whiteheads or blackheads, and can be symptomatic, with itchy or tender lesions. NCI:CTCAE NCIT:C80119 An acute or chronic infection of the soft tissues around the nail. Symptoms include pain, tenderness, erythema, and swelling around the nail. Acute infection results from minor trauma to the fingertip and Staphylococcus aureus is usually the causative agent. Chronic infection is usually caused by Candida albicans OR A disorder characterized by an infectious process involving the soft tissues around the nail. CCTO:000637 implies CCTO:000049 CCTO:000637 implies CCTO:001119 CCTO:000637(time_t t0) = EVENT_STATE(CCTO:000637, t0) NCI:CTCAE:10034016 NCIT:C79702 UMLS:C0030578 UMLS:C1075202 cancer_care_treatment_outcome CCTO:000637 Paronychia CCTO:000637 An acute or chronic infection of the soft tissues around the nail. Symptoms include pain, tenderness, erythema, and swelling around the nail. Acute infection results from minor trauma to the fingertip and Staphylococcus aureus is usually the causative agent. Chronic infection is usually caused by Candida albicans OR A disorder characterized by an infectious process involving the soft tissues around the nail. NCI:CTCAE NCIT:C79702 Pelvic inflammatory disease (PID) is an acute or chronic inflammation in the pelvic cavity. It is most commonly caused by sexually transmitted diseases, including chlamydia and gonorrhea that have ascended into the uterus, fallopian tubes, or ovaries as a result of intercourse or childbirth, or of surgical procedures, including insertion of IUDs or abortion. PID may be either symptomatic or asymptomatic. It may cause infertility and it may raise the risk of ectopic pregnancy. PID is a disease associated with HIV infection OR A disorder characterized by an infectious process involving the pelvic cavity. CCTO:000638 implies CCTO:000049 CCTO:000638 implies CCTO:001119 CCTO:000638(time_t t0) = EVENT_STATE(CCTO:000638, t0) NCI:CTCAE:10058674 NCIT:C3889 UMLS:C0030790 UMLS:C0242172 UMLS:C1417406 Disease (PID), Pelvic Inflammatory Inflammatory Disease (PID), Pelvic PID PID, Pelvic Inflammatory Disease Pelvic Inflammatory Disease, (PID) Pelvic inflammatory disease cancer_care_treatment_outcome CCTO:000638 Pelvic infection CCTO:000638 Pelvic inflammatory disease (PID) is an acute or chronic inflammation in the pelvic cavity. It is most commonly caused by sexually transmitted diseases, including chlamydia and gonorrhea that have ascended into the uterus, fallopian tubes, or ovaries as a result of intercourse or childbirth, or of surgical procedures, including insertion of IUDs or abortion. PID may be either symptomatic or asymptomatic. It may cause infertility and it may raise the risk of ectopic pregnancy. PID is a disease associated with HIV infection OR A disorder characterized by an infectious process involving the pelvic cavity. NCI:CTCAE NCIT:C3889 Disease (PID), Pelvic Inflammatory NCIT:C3889 Inflammatory Disease (PID), Pelvic NCIT:C3889 PID NCIT:C3889 PID, Pelvic Inflammatory Disease NCIT:C3889 Pelvic Inflammatory Disease, (PID) NCIT:C3889 Pelvic inflammatory disease NCIT:C3889 A disorder characterized by an infectious process involving the penis OR An infectious process affecting the penis. CCTO:000639 implies CCTO:000049 CCTO:000639 implies CCTO:001119 CCTO:000639(time_t t0) = EVENT_STATE(CCTO:000639, t0) NCI:CTCAE:10061912 NCIT:C78526 UMLS:C0581395 cancer_care_treatment_outcome CCTO:000639 Penile infection CCTO:000639 A disorder characterized by an infectious process involving the penis OR An infectious process affecting the penis. NCI:CTCAE NCIT:C78526 An infectious process affecting the tissues around the orbit OR A disorder characterized by an infectious process involving the orbit of the eye. CCTO:000640 implies CCTO:000049 CCTO:000640 implies CCTO:001119 CCTO:000640(time_t t0) = EVENT_STATE(CCTO:000640, t0) NCI:CTCAE:10051472 NCIT:C78531 UMLS:C0948065 cancer_care_treatment_outcome CCTO:000640 Periorbital infection CCTO:000640 An infectious process affecting the tissues around the orbit OR A disorder characterized by an infectious process involving the orbit of the eye. NCI:CTCAE NCIT:C78531 A disorder characterized by an infectious process involving the peripheral nerves OR An infectious process affecting the peripheral nerves. CCTO:000641 implies CCTO:000049 CCTO:000641 implies CCTO:001119 CCTO:000641(time_t t0) = EVENT_STATE(CCTO:000641, t0) NCI:CTCAE:10065766 NCIT:C27589 UMLS:C1278821 Peripheral nervous system infectious disorder cancer_care_treatment_outcome CCTO:000641 Peripheral nerve infection CCTO:000641 A disorder characterized by an infectious process involving the peripheral nerves OR An infectious process affecting the peripheral nerves. NCI:CTCAE NCIT:C27589 Peripheral nervous system infectious disorder NCIT:C27589 An infectious process affecting the peritoneum OR A disorder characterized by an infectious process involving the peritoneum. CCTO:000642 implies CCTO:000049 CCTO:000642 implies CCTO:001119 CCTO:000642(time_t t0) = EVENT_STATE(CCTO:000642, t0) NCI:CTCAE:10057262 NCIT:C78540 UMLS:C0851980 cancer_care_treatment_outcome CCTO:000642 Peritoneal infection CCTO:000642 An infectious process affecting the peritoneum OR A disorder characterized by an infectious process involving the peritoneum. NCI:CTCAE NCIT:C78540 A disorder characterized by of marked discomfort in the throat OR Inflammation of the throat most often caused by viral and bacterial infections. Other causes include allergens, chemical substances, and trauma OR Any kind of inflammatory process of the tonsils, pharynx, or/and larynx characterized by pain in swallowing. CCTO:000643 implies CCTO:000049 CCTO:000643 implies CCTO:001119 CCTO:000643 implies CCTO:001127 CCTO:000643(time_t t0) = EVENT_STATE(CCTO:000643, t0) NCI:CTCAE:10034835 NCI:CTCAE:10041367 NCIT:C26851 NCIT:C50747 UMLS:C0031350 UMLS:C0242429 Sore throat Throat, sore cancer_care_treatment_outcome CCTO:000643 Pharyngitis CCTO:000643 A disorder characterized by of marked discomfort in the throat OR Inflammation of the throat most often caused by viral and bacterial infections. Other causes include allergens, chemical substances, and trauma OR Any kind of inflammatory process of the tonsils, pharynx, or/and larynx characterized by pain in swallowing. NCI:CTCAE NCIT:C26851 NCIT:C50747 Sore throat NCIT:C50747 Throat, sore NCIT:C50747 A disorder characterized by an infectious process involving the vein. Clinical manifestations include erythema, marked discomfort, swelling, and induration along the course of the infected vein OR Infection at the site of needle puncture or intravenous catheter placement due to poor aseptic techniques. It is characterized by erythema, pain, swelling, and induration at the catheter insertion site. CCTO:000644 implies CCTO:000049 CCTO:000644 implies CCTO:001119 CCTO:000644(time_t t0) = EVENT_STATE(CCTO:000644, t0) NCI:CTCAE:10056627 NCIT:C78558 UMLS:C1112243 Infective phlebitis cancer_care_treatment_outcome CCTO:000644 Phlebitis infective CCTO:000644 A disorder characterized by an infectious process involving the vein. Clinical manifestations include erythema, marked discomfort, swelling, and induration along the course of the infected vein OR Infection at the site of needle puncture or intravenous catheter placement due to poor aseptic techniques. It is characterized by erythema, pain, swelling, and induration at the catheter insertion site. NCI:CTCAE NCIT:C78558 Infective phlebitis NCIT:C78558 An infectious process affecting the pleura OR A disorder characterized by an infectious process involving the pleura. CCTO:000645 implies CCTO:000049 CCTO:000645 implies CCTO:001119 CCTO:000645(time_t t0) = EVENT_STATE(CCTO:000645, t0) NCI:CTCAE:10061351 NCIT:C78563 UMLS:C0919907 cancer_care_treatment_outcome CCTO:000645 Pleural infection CCTO:000645 An infectious process affecting the pleura OR A disorder characterized by an infectious process involving the pleura. NCI:CTCAE NCIT:C78563 A disorder characterized by an infectious process involving the prostate gland OR An acute or chronic infectious process affecting the prostate gland. CCTO:000646 implies CCTO:000049 CCTO:000646 implies CCTO:001119 CCTO:000646(time_t t0) = EVENT_STATE(CCTO:000646, t0) NCI:CTCAE:10050662 NCIT:C27615 UMLS:C0240811 Prostatic infection cancer_care_treatment_outcome CCTO:000646 Prostate infection CCTO:000646 A disorder characterized by an infectious process involving the prostate gland OR An acute or chronic infectious process affecting the prostate gland. NCI:CTCAE NCIT:C27615 Prostatic infection NCIT:C27615 Elevated skin lesions associated with the presence of purulent material OR A disorder characterized by a circumscribed and elevated skin lesion filled with pus. CCTO:000647 implies CCTO:000049 CCTO:000647 implies CCTO:001119 CCTO:000647(time_t t0) = EVENT_STATE(CCTO:000647, t0) NCI:CTCAE:10037888 NCIT:C90597 UMLS:C0085641 Pustular rash cancer_care_treatment_outcome CCTO:000647 Rash pustular CCTO:000647 Elevated skin lesions associated with the presence of purulent material OR A disorder characterized by a circumscribed and elevated skin lesion filled with pus. NCI:CTCAE NCIT:C90597 Pustular rash NCIT:C90597 An inflammatory process affecting the nasal mucosa, usually caused by viruses (e.g., rhinovirus, adenovirus, parainfluenza virus, and coronavirus). It is characterized by chills, headaches, mucopurulent nasal discharge, coughing, and facial pain OR A disorder characterized by an infectious process involving the nasal mucosal. CCTO:000648 implies CCTO:000049 CCTO:000648 implies CCTO:001119 CCTO:000648(time_t t0) = EVENT_STATE(CCTO:000648, t0) NCI:CTCAE:10059827 NCIT:C78599 UMLS:C0009443 Infectious rhinitis Non-allergic rhinitis cancer_care_treatment_outcome CCTO:000648 Rhinitis infective CCTO:000648 An inflammatory process affecting the nasal mucosa, usually caused by viruses (e.g., rhinovirus, adenovirus, parainfluenza virus, and coronavirus). It is characterized by chills, headaches, mucopurulent nasal discharge, coughing, and facial pain OR A disorder characterized by an infectious process involving the nasal mucosal. NCI:CTCAE NCIT:C78599 Infectious rhinitis NCIT:C78599 Non-allergic rhinitis NCIT:C78599 A viral (such as mumps) or bacterial infectious process affecting the salivary gland. The salivary gland becomes enlarged and is often painful OR A disorder characterized by an infectious process involving the salivary gland. CCTO:000649 implies CCTO:000049 CCTO:000649 implies CCTO:001119 CCTO:000649(time_t t0) = EVENT_STATE(CCTO:000649, t0) NCI:CTCAE:10039413 NCIT:C78601 UMLS:C0392318 cancer_care_treatment_outcome CCTO:000649 Salivary gland infection CCTO:000649 A viral (such as mumps) or bacterial infectious process affecting the salivary gland. The salivary gland becomes enlarged and is often painful OR A disorder characterized by an infectious process involving the salivary gland. NCI:CTCAE NCIT:C78601 A disorder characterized by an infectious process involving the scrotum OR A bacterial, fungal or viral infectious process affecting the scrotum. CCTO:000650 implies CCTO:000049 CCTO:000650 implies CCTO:001119 CCTO:000650(time_t t0) = EVENT_STATE(CCTO:000650, t0) NCI:CTCAE:10062156 NCIT:C78606 UMLS:C1299539 cancer_care_treatment_outcome CCTO:000650 Scrotal infection CCTO:000650 A disorder characterized by an infectious process involving the scrotum OR A bacterial, fungal or viral infectious process affecting the scrotum. NCI:CTCAE NCIT:C78606 A disorder characterized by the presence of pathogenic microorganisms in the blood stream that cause a rapidly progressing systemic reaction that may lead to shock OR The presence of pathogenic microorganisms in the blood stream causing a rapidly progressing systemic reaction that may lead to shock. Symptoms include fever, chills, tachycardia, and increased respiratory rate. It is a medical emergency that requires urgent medical attention. CCTO:000651 implies CCTO:000049 CCTO:000651 implies CCTO:001119 CCTO:000651(time_t t0) = EVENT_STATE(CCTO:000651, t0) NCI:CTCAE:10040047 NCIT:C3364 UMLS:C0036690 UMLS:C0040524 UMLS:C0242966 UMLS:C0243026 UMLS:C0542241 Sepsis syndrome Septicemia blood poisoning toxemia cancer_care_treatment_outcome CCTO:000651 Sepsis CCTO:000651 A disorder characterized by the presence of pathogenic microorganisms in the blood stream that cause a rapidly progressing systemic reaction that may lead to shock OR The presence of pathogenic microorganisms in the blood stream causing a rapidly progressing systemic reaction that may lead to shock. Symptoms include fever, chills, tachycardia, and increased respiratory rate. It is a medical emergency that requires urgent medical attention. NCI:CTCAE NCIT:C3364 Sepsis syndrome NCIT:C3364 Septicemia NCIT:C3364 blood poisoning NCIT:C3364 toxemia NCIT:C3364 A disorder characterized by an infectious process involving the mucous membranes of the paranasal sinuses OR An acute or chronic inflammatory process affecting the mucous membranes of any sinus cavity. CCTO:000652 implies CCTO:000049 CCTO:000652 implies CCTO:001119 CCTO:000652(time_t t0) = EVENT_STATE(CCTO:000652, t0) NCI:CTCAE:10040753 NCIT:C35024 UMLS:C0037199 cancer_care_treatment_outcome CCTO:000652 Sinusitis CCTO:000652 A disorder characterized by an infectious process involving the mucous membranes of the paranasal sinuses OR An acute or chronic inflammatory process affecting the mucous membranes of any sinus cavity. NCI:CTCAE NCIT:C35024 An inflammatory process affecting the skin, caused by bacteria, viruses, parasites, or fungi. Examples of bacterial infection include carbuncles, furuncles, impetigo, erysipelas, and abscesses. Examples of viral infection include shingles, warts, molluscum contagiosum, and pityriasis rosea. Examples of parasitic infection include scabies and lice. Examples of fungal infection include athlete's foot, yeast infection, and ringworm OR A disorder characterized by an infectious process involving the skin. CCTO:000653 implies CCTO:000049 CCTO:000653 implies CCTO:001119 CCTO:000653(time_t t0) = EVENT_STATE(CCTO:000653, t0) NCI:CTCAE:10040872 NCIT:C35025 UMLS:C0037278 cancer_care_treatment_outcome CCTO:000653 Skin infection CCTO:000653 An inflammatory process affecting the skin, caused by bacteria, viruses, parasites, or fungi. Examples of bacterial infection include carbuncles, furuncles, impetigo, erysipelas, and abscesses. Examples of viral infection include shingles, warts, molluscum contagiosum, and pityriasis rosea. Examples of parasitic infection include scabies and lice. Examples of fungal infection include athlete's foot, yeast infection, and ringworm OR A disorder characterized by an infectious process involving the skin. NCI:CTCAE NCIT:C35025 An infectious process affecting the small intestine OR A disorder characterized by an infectious process involving the small intestine. CCTO:000654 implies CCTO:000049 CCTO:000654 implies CCTO:001119 CCTO:000654(time_t t0) = EVENT_STATE(CCTO:000654, t0) NCI:CTCAE:10065771 NCIT:C78618 UMLS:C1698036 Small intestinal infection cancer_care_treatment_outcome CCTO:000654 Small intestine infection CCTO:000654 An infectious process affecting the small intestine OR A disorder characterized by an infectious process involving the small intestine. NCI:CTCAE NCIT:C78618 Small intestinal infection NCIT:C78618 A bacterial infectious process affecting the soft tissues. A severe form caused by anaerobic or aerobic bacteria is associated with soft tissues necrosis and affects the subcutaneous adipose tissue, muscles, fascia, and the skin OR A disorder characterized by an infectious process involving soft tissues. CCTO:000655 implies CCTO:000049 CCTO:000655 implies CCTO:001119 CCTO:000655(time_t t0) = EVENT_STATE(CCTO:000655, t0) NCI:CTCAE:10062255 NCIT:C79745 UMLS:C0149778 cancer_care_treatment_outcome CCTO:000655 Soft tissue infection CCTO:000655 A bacterial infectious process affecting the soft tissues. A severe form caused by anaerobic or aerobic bacteria is associated with soft tissues necrosis and affects the subcutaneous adipose tissue, muscles, fascia, and the skin OR A disorder characterized by an infectious process involving soft tissues. NCI:CTCAE NCIT:C79745 An infectious process affecting the spleen. Predisposing factors include immunosuppression, diabetes mellitus, and sickle cell anemia. Infectious agents include bacteria (e.g., staphylococcus and streptococcus) and fungi OR A disorder characterized by an infectious process involving the spleen. CCTO:000656 implies CCTO:000049 CCTO:000656 implies CCTO:001119 CCTO:000656(time_t t0) = EVENT_STATE(CCTO:000656, t0) NCI:CTCAE:10062112 NCIT:C78627 UMLS:C0948149 cancer_care_treatment_outcome CCTO:000656 Splenic infection CCTO:000656 An infectious process affecting the spleen. Predisposing factors include immunosuppression, diabetes mellitus, and sickle cell anemia. Infectious agents include bacteria (e.g., staphylococcus and streptococcus) and fungi OR A disorder characterized by an infectious process involving the spleen. NCI:CTCAE NCIT:C78627 A disorder characterized by an infectious process involving a stoma (surgically created opening on the surface of the body) OR An infectious process affecting a surgically created opening in the surface of the body. CCTO:000657 implies CCTO:000049 CCTO:000657 implies CCTO:001119 CCTO:000657(time_t t0) = EVENT_STATE(CCTO:000657, t0) NCI:CTCAE:10064505 NCIT:C78629 UMLS:C1610624 cancer_care_treatment_outcome CCTO:000657 Stoma site infection CCTO:000657 A disorder characterized by an infectious process involving a stoma (surgically created opening on the surface of the body) OR An infectious process affecting a surgically created opening in the surface of the body. NCI:CTCAE NCIT:C78629 An infectious process affecting a tooth OR A disorder characterized by an infectious process involving a tooth. CCTO:000658 implies CCTO:000049 CCTO:000658 implies CCTO:001119 CCTO:000658(time_t t0) = EVENT_STATE(CCTO:000658, t0) NCI:CTCAE:10048762 NCIT:C78639 UMLS:C0877046 Dental infection cancer_care_treatment_outcome CCTO:000658 Tooth infection CCTO:000658 An infectious process affecting a tooth OR A disorder characterized by an infectious process involving a tooth. NCI:CTCAE NCIT:C78639 Dental infection NCIT:C78639 An inflammatory process affecting the wall of the trachea OR Bacterial infectious process with formation of mucopurulent membranes affecting the trachea. Causative agents include Staphylococcus, Streptococcus, Haemophilus influenzae, Pseudomonas, and Klebsiella OR A disorder characterized by an infectious process involving the trachea. CCTO:000659 implies CCTO:000049 CCTO:000659 implies CCTO:001119 CCTO:000659(time_t t0) = EVENT_STATE(CCTO:000659, t0) NCI:CTCAE:10044302 NCIT:C78643 NCIT:C78647 UMLS:C0040584 UMLS:C1697280 UMLS:C1868703 Bacterial tracheitis Tracheal inflammation cancer_care_treatment_outcome CCTO:000659 Tracheitis CCTO:000659 An inflammatory process affecting the wall of the trachea OR Bacterial infectious process with formation of mucopurulent membranes affecting the trachea. Causative agents include Staphylococcus, Streptococcus, Haemophilus influenzae, Pseudomonas, and Klebsiella OR A disorder characterized by an infectious process involving the trachea. NCI:CTCAE NCIT:C78643 NCIT:C78647 Bacterial tracheitis NCIT:C78647 Tracheal inflammation NCIT:C78643 A disorder characterized by an infectious process involving the upper respiratory tract (nose, paranasal sinuses, pharynx, larynx, or trachea) OR An infectious process affecting the upper respiratory tract (nose, paranasal sinuses, pharynx, larynx, or trachea). Symptoms include congestion, sneezing, coughing, fever, and sore throat. CCTO:000660 implies CCTO:000049 CCTO:000660 implies CCTO:001119 CCTO:000660(time_t t0) = EVENT_STATE(CCTO:000660, t0) NCI:CTCAE:10046300 NCIT:C35650 UMLS:C0009443 UMLS:C0024117 UMLS:C0041912 UMLS:C0234192 UMLS:C0877266 Cold Infection, upper respiratory tract Upper respiratory tract infection Upper respiratory tract inflammation cancer_care_treatment_outcome CCTO:000660 Upper respiratory infection CCTO:000660 A disorder characterized by an infectious process involving the upper respiratory tract (nose, paranasal sinuses, pharynx, larynx, or trachea) OR An infectious process affecting the upper respiratory tract (nose, paranasal sinuses, pharynx, larynx, or trachea). Symptoms include congestion, sneezing, coughing, fever, and sore throat. NCI:CTCAE NCIT:C35650 Cold NCIT:C35650 Infection, upper respiratory tract NCIT:C35650 Upper respiratory tract infection NCIT:C35650 Upper respiratory tract inflammation NCIT:C35650 A disorder characterized by an infectious process involving the urethra OR A bacterial, viral, or fungal infectious process affecting the urethra. CCTO:000661 implies CCTO:000049 CCTO:000661 implies CCTO:001119 CCTO:000661(time_t t0) = EVENT_STATE(CCTO:000661, t0) NCI:CTCAE:10052298 NCIT:C78671 UMLS:C0948357 cancer_care_treatment_outcome CCTO:000661 Urethral infection CCTO:000661 A disorder characterized by an infectious process involving the urethra OR A bacterial, viral, or fungal infectious process affecting the urethra. NCI:CTCAE NCIT:C78671 A disorder characterized by an infectious process involving the urinary tract, most commonly the bladder and the urethra OR A bacterial infectious process affecting any part of the urinary tract, most commonly the bladder and the urethra. Symptoms include urinary urgency and frequency, burning sensation during urination, lower abdominal discomfort, and cloudy urine. CCTO:000662 implies CCTO:000049 CCTO:000662 implies CCTO:001119 CCTO:000662(time_t t0) = EVENT_STATE(CCTO:000662, t0) NCI:CTCAE:10046571 NCIT:C50791 UMLS:C0042029 Infection, urinary tract Tract, infection of urinary UTI Urinary tract infectious disease cancer_care_treatment_outcome CCTO:000662 Urinary tract infection CCTO:000662 A disorder characterized by an infectious process involving the urinary tract, most commonly the bladder and the urethra OR A bacterial infectious process affecting any part of the urinary tract, most commonly the bladder and the urethra. Symptoms include urinary urgency and frequency, burning sensation during urination, lower abdominal discomfort, and cloudy urine. NCI:CTCAE NCIT:C50791 Infection, urinary tract NCIT:C50791 Tract, infection of urinary NCIT:C50791 UTI NCIT:C50791 Urinary tract infectious disease NCIT:C50791 An acute or chronic, usually bacterial infectious process affecting the endometrium. It may extend to the myometrium and parametrial tissues. Symptoms include lower abdominal pain, vaginal discharge, and vaginal bleeding OR A disorder characterized by an infectious process involving the endometrium. It may extend to the myometrium and parametrial tissues. CCTO:000663 implies CCTO:000049 CCTO:000663 implies CCTO:001119 CCTO:000663(time_t t0) = EVENT_STATE(CCTO:000663, t0) NCI:CTCAE:10062233 NCIT:C26764 UMLS:C0014179 UMLS:C0042136 Endometritis cancer_care_treatment_outcome CCTO:000663 Uterine infection CCTO:000663 An acute or chronic, usually bacterial infectious process affecting the endometrium. It may extend to the myometrium and parametrial tissues. Symptoms include lower abdominal pain, vaginal discharge, and vaginal bleeding OR A disorder characterized by an infectious process involving the endometrium. It may extend to the myometrium and parametrial tissues. NCI:CTCAE NCIT:C26764 Endometritis NCIT:C26764 An infectious process affecting the vagina. Symptoms include pain and purulent discharge OR A disorder characterized by an infectious process involving the vagina. CCTO:000664 implies CCTO:000049 CCTO:000664 implies CCTO:001119 CCTO:000664(time_t t0) = EVENT_STATE(CCTO:000664, t0) NCI:CTCAE:10046914 NCIT:C84353 UMLS:C0404521 cancer_care_treatment_outcome CCTO:000664 Vaginal infection CCTO:000664 An infectious process affecting the vagina. Symptoms include pain and purulent discharge OR A disorder characterized by an infectious process involving the vagina. NCI:CTCAE NCIT:C84353 A disorder characterized by an infectious process involving the vulva OR An infectious process affecting the vulva. Causative agents include human papillomavirus, herpes virus, Trichomonas, and Candida. Symptoms include itching and pain in the genital area and discharge. CCTO:000665 implies CCTO:000049 CCTO:000665 implies CCTO:001119 CCTO:000665(time_t t0) = EVENT_STATE(CCTO:000665, t0) NCI:CTCAE:10065772 NCIT:C78716 UMLS:C1699561 cancer_care_treatment_outcome CCTO:000665 Vulval infection CCTO:000665 A disorder characterized by an infectious process involving the vulva OR An infectious process affecting the vulva. Causative agents include human papillomavirus, herpes virus, Trichomonas, and Candida. Symptoms include itching and pain in the genital area and discharge. NCI:CTCAE NCIT:C78716 Infection of a break in the skin or other tissue OR A disorder characterized by an infectious process involving the wound. CCTO:000666 implies CCTO:000049 CCTO:000666 implies CCTO:001119 CCTO:000666(time_t t0) = EVENT_STATE(CCTO:000666, t0) NCI:CTCAE:10048038 NCIT:C45234 UMLS:C0043241 cancer_care_treatment_outcome CCTO:000666 Wound infection CCTO:000666 Infection of a break in the skin or other tissue OR A disorder characterized by an infectious process involving the wound. NCI:CTCAE NCIT:C45234 Traumatic or pathological injury to the ankle joint in which the continuity of an ankle bone is broken. Symptoms include pain, swelling, and difficulty moving the affected leg and foot OR A finding of damage to the ankle joint characterized by a break in the continuity of the ankle bone. Symptoms include marked discomfort, swelling and difficulty moving the affected leg and foot. CCTO:000667 implies CCTO:000049 CCTO:000667 implies CCTO:001120 CCTO:000667(time_t t0) = EVENT_STATE(CCTO:000667, t0) NCI:CTCAE:10002544 NCIT:C26989 UMLS:C0159877 cancer_care_treatment_outcome CCTO:000667 Ankle fracture CCTO:000667 Traumatic or pathological injury to the ankle joint in which the continuity of an ankle bone is broken. Symptoms include pain, swelling, and difficulty moving the affected leg and foot OR A finding of damage to the ankle joint characterized by a break in the continuity of the ankle bone. Symptoms include marked discomfort, swelling and difficulty moving the affected leg and foot. NCI:CTCAE NCIT:C26989 A finding of damage to the aorta OR Damage to the aorta from traumatic or pathologic processes. CCTO:000668 implies CCTO:000049 CCTO:000668 implies CCTO:001120 CCTO:000668(time_t t0) = EVENT_STATE(CCTO:000668, t0) NCI:CTCAE:10002899 NCIT:C35623 UMLS:C0854391 cancer_care_treatment_outcome CCTO:000668 Aortic injury CCTO:000668 A finding of damage to the aorta OR Damage to the aorta from traumatic or pathologic processes. NCI:CTCAE NCIT:C35623 A finding of damage to an artery OR Damage to an artery from traumatic or pathologic processes. CCTO:000669 implies CCTO:000049 CCTO:000669 implies CCTO:001120 CCTO:000669(time_t t0) = EVENT_STATE(CCTO:000669, t0) NCI:CTCAE:10003162 NCIT:C35401 UMLS:C0340652 cancer_care_treatment_outcome CCTO:000669 Arterial injury CCTO:000669 A finding of damage to an artery OR Damage to an artery from traumatic or pathologic processes. NCI:CTCAE NCIT:C35401 Leakage of bile due to breakdown of a biliary anastomosis OR A finding of leakage of bile due to breakdown of a biliary anastomosis (surgical connection of two separate anatomic structures). CCTO:000670 implies CCTO:000049 CCTO:000670 implies CCTO:001120 CCTO:000670(time_t t0) = EVENT_STATE(CCTO:000670, t0) NCI:CTCAE:10050458 NCIT:C78183 UMLS:C0401006 Biliary anastomotic leakage cancer_care_treatment_outcome CCTO:000670 Biliary anastomotic leak CCTO:000670 Leakage of bile due to breakdown of a biliary anastomosis OR A finding of leakage of bile due to breakdown of a biliary anastomosis (surgical connection of two separate anatomic structures). NCI:CTCAE NCIT:C78183 Biliary anastomotic leakage NCIT:C78183 Leakage of urine due to breakdown of a bladder anastomosis OR A finding of leakage of urine due to breakdown of a bladder anastomosis (surgical connection of two separate anatomic structures). CCTO:000671 implies CCTO:000049 CCTO:000671 implies CCTO:001120 CCTO:000671(time_t t0) = EVENT_STATE(CCTO:000671, t0) NCI:CTCAE:10065802 NCIT:C78206 UMLS:C1697974 Bladder anastomotic leakage cancer_care_treatment_outcome CCTO:000671 Bladder anastomotic leak CCTO:000671 Leakage of urine due to breakdown of a bladder anastomosis OR A finding of leakage of urine due to breakdown of a bladder anastomosis (surgical connection of two separate anatomic structures). NCI:CTCAE NCIT:C78206 Bladder anastomotic leakage NCIT:C78206 A finding of injury of the soft tissues or bone characterized by leakage of blood into surrounding tissues OR Injury of the soft tissues or bone without breaking the skin that is characterized by blood leakage into the surrounding area. CCTO:000672 implies CCTO:000049 CCTO:000672 implies CCTO:001120 CCTO:000672(time_t t0) = EVENT_STATE(CCTO:000672, t0) NCI:CTCAE:10006504 NCIT:C37921 UMLS:C0009938 UMLS:C3812660 Bruise cancer_care_treatment_outcome CCTO:000672 Bruising CCTO:000672 A finding of injury of the soft tissues or bone characterized by leakage of blood into surrounding tissues OR Injury of the soft tissues or bone without breaking the skin that is characterized by blood leakage into the surrounding area. NCI:CTCAE NCIT:C37921 Bruise NCIT:C37921 A traumatic injury involving interruption of tissue cohesiveness that results from exposure to caustic chemicals, extreme heat, extreme cold or excessive radiation OR A finding of impaired integrity to the anatomic site of an adverse thermal reaction. Burns can be caused by exposure to chemicals, direct heat, electricity, flames and radiation. The extent of damage depends on the length and intensity of exposure and time until provision of treatment. CCTO:000673 implies CCTO:000049 CCTO:000673 implies CCTO:001120 CCTO:000673(time_t t0) = EVENT_STATE(CCTO:000673, t0) NCI:CTCAE:10006634 NCIT:C34441 NCIT:C57900 NCIT:C63286 UMLS:C0006434 UMLS:C1879905 UMLS:C1962979 Burn adverse event Burn of device or device component Burn(s) Burned Burned Medical Device or Device Component Burnt cancer_care_treatment_outcome CCTO:000673 Burn CCTO:000673 A traumatic injury involving interruption of tissue cohesiveness that results from exposure to caustic chemicals, extreme heat, extreme cold or excessive radiation OR A finding of impaired integrity to the anatomic site of an adverse thermal reaction. Burns can be caused by exposure to chemicals, direct heat, electricity, flames and radiation. The extent of damage depends on the length and intensity of exposure and time until provision of treatment. NCI:CTCAE NCIT:C34441 Burn adverse event NCIT:C57900 Burn of device or device component NCIT:C63286 Burn(s) NCIT:C34441 Burned NCIT:C63286 Burned Medical Device or Device Component NCIT:C63286 Burnt NCIT:C63286 A finding of cutaneous inflammatory reaction occurring as a result of exposure to biologically effective levels of ionizing radiation OR A cutaneous inflammatory reaction occurring as a result of exposure to biologically effective levels of ionizing radiation. CCTO:000674 implies CCTO:000049 CCTO:000674 implies CCTO:001120 CCTO:000674(time_t t0) = EVENT_STATE(CCTO:000674, t0) NCI:CTCAE:10061103 NCIT:C3349 UMLS:C0034561 Radiation dermatitis Radiation-induced dermatitis Radiodermatitis cancer_care_treatment_outcome CCTO:000674 Dermatitis radiation CCTO:000674 A finding of cutaneous inflammatory reaction occurring as a result of exposure to biologically effective levels of ionizing radiation OR A cutaneous inflammatory reaction occurring as a result of exposure to biologically effective levels of ionizing radiation. NCI:CTCAE NCIT:C3349 Radiation dermatitis NCIT:C3349 Radiation-induced dermatitis NCIT:C3349 Radiodermatitis NCIT:C3349 Leakage due to breakdown of an esophageal anastomosis OR A finding of leakage due to breakdown of an esophageal anastomosis (surgical connection of two separate anatomic structures). CCTO:000675 implies CCTO:000049 CCTO:000675 implies CCTO:001120 CCTO:000675(time_t t0) = EVENT_STATE(CCTO:000675, t0) NCI:CTCAE:10065961 NCIT:C78270 UMLS:C0341563 Esophageal anastomotic leakage cancer_care_treatment_outcome CCTO:000675 Esophageal anastomotic leak CCTO:000675 Leakage due to breakdown of an esophageal anastomosis OR A finding of leakage due to breakdown of an esophageal anastomosis (surgical connection of two separate anatomic structures). NCI:CTCAE NCIT:C78270 Esophageal anastomotic leakage NCIT:C78270 A finding of sudden movement downward, usually resulting in injury OR The season between the autumnal equinox and the winter solstice OR A sudden movement downward, usually resulting in injury. CCTO:000676 implies CCTO:000049 CCTO:000676 implies CCTO:001120 CCTO:000676(time_t t0) = EVENT_STATE(CCTO:000676, t0) NCI:CTCAE:10016173 NCIT:C50558 NCIT:C94733 UMLS:C0085639 UMLS:C0238715 Autumn cancer_care_treatment_outcome CCTO:000676 Fall CCTO:000676 A finding of sudden movement downward, usually resulting in injury OR The season between the autumnal equinox and the winter solstice OR A sudden movement downward, usually resulting in injury. NCI:CTCAE NCIT:C50558 NCIT:C94733 Autumn NCIT:C94733 A finding of leakage due to breakdown of a fallopian tube anastomosis (surgical connection of two separate anatomic structures) OR Leakage due to breakdown of a fallopian tube anastomosis. CCTO:000677 implies CCTO:000049 CCTO:000677 implies CCTO:001120 CCTO:000677(time_t t0) = EVENT_STATE(CCTO:000677, t0) NCI:CTCAE:10065788 NCIT:C78292 UMLS:C1698039 Fallopian tube anastomotic leakage cancer_care_treatment_outcome CCTO:000677 Fallopian tube anastomotic leak CCTO:000677 A finding of leakage due to breakdown of a fallopian tube anastomosis (surgical connection of two separate anatomic structures) OR Leakage due to breakdown of a fallopian tube anastomosis. NCI:CTCAE NCIT:C78292 Fallopian tube anastomotic leakage NCIT:C78292 A finding of rupture of the fallopian tube wall OR A rupture of the fallopian tube wall due to tubal pregnancy, or other traumatic or pathologic processes. CCTO:000678 implies CCTO:000049 CCTO:000678 implies CCTO:001120 CCTO:000678(time_t t0) = EVENT_STATE(CCTO:000678, t0) NCI:CTCAE:10065790 NCIT:C57060 NCIT:C78294 UMLS:C1557983 UMLS:C1963109 Fallopian tube perforation adverse event cancer_care_treatment_outcome CCTO:000678 Fallopian tube perforation CCTO:000678 A finding of rupture of the fallopian tube wall OR A rupture of the fallopian tube wall due to tubal pregnancy, or other traumatic or pathologic processes. NCI:CTCAE NCIT:C78294 Fallopian tube perforation adverse event NCIT:C57060 A finding of traumatic injury to the bone in which the continuity of the bone is broken OR A traumatic injury to the bone in which the continuity of the bone is broken. CCTO:000679 implies CCTO:000049 CCTO:000679 implies CCTO:001120 CCTO:000679(time_t t0) = EVENT_STATE(CCTO:000679, t0) NCI:CTCAE:10017076 NCIT:C3046 NCIT:C58382 NCIT:C63132 UMLS:C0016658 UMLS:C1880851 UMLS:C1963113 Bone fracture Fracture adverse event Fracture of Bone Fracture of Medical Device Material Fracture(s) Fracture(s) Of Device/Material cancer_care_treatment_outcome CCTO:000679 Fracture CCTO:000679 A finding of traumatic injury to the bone in which the continuity of the bone is broken OR A traumatic injury to the bone in which the continuity of the bone is broken. NCI:CTCAE NCIT:C3046 Bone fracture NCIT:C3046 Fracture adverse event NCIT:C58382 Fracture of Bone NCIT:C3046 Fracture of Medical Device Material NCIT:C63132 Fracture(s) NCIT:C3046 Fracture(s) Of Device/Material NCIT:C63132 A finding of leakage due to breakdown of a gastric anastomosis (surgical connection of two separate anatomic structures) OR Leakage due to breakdown of a gastric anastomosis. CCTO:000680 implies CCTO:000049 CCTO:000680 implies CCTO:001120 CCTO:000680(time_t t0) = EVENT_STATE(CCTO:000680, t0) NCI:CTCAE:10065893 NCIT:C78310 UMLS:C0341564 Gastric anastomotic leakage cancer_care_treatment_outcome CCTO:000680 Gastric anastomotic leak CCTO:000680 A finding of leakage due to breakdown of a gastric anastomosis (surgical connection of two separate anatomic structures) OR Leakage due to breakdown of a gastric anastomosis. NCI:CTCAE NCIT:C78310 Gastric anastomotic leakage NCIT:C78310 A finding of leakage due to breakdown of a gastrointestinal anastomosis (surgical connection of two separate anatomic structures) OR Leakage due to breakdown of a gastrointestinal anastomosis. CCTO:000681 implies CCTO:000049 CCTO:000681 implies CCTO:001120 CCTO:000681(time_t t0) = EVENT_STATE(CCTO:000681, t0) NCI:CTCAE:10065879 NCIT:C78318 UMLS:C0341562 Digestive system anastomotic leakage Gastrointestinal system anastomotic leakage cancer_care_treatment_outcome CCTO:000681 Gastrointestinal anastomotic leak CCTO:000681 A finding of leakage due to breakdown of a gastrointestinal anastomosis (surgical connection of two separate anatomic structures) OR Leakage due to breakdown of a gastrointestinal anastomosis. NCI:CTCAE NCIT:C78318 Digestive system anastomotic leakage NCIT:C78318 Gastrointestinal system anastomotic leakage NCIT:C78318 A finding of a necrotic process occurring in the gastrointestinal tract stoma OR A necrotic process affecting the post-operative stoma area in the gastrointestinal tract. CCTO:000682 implies CCTO:000049 CCTO:000682 implies CCTO:001120 CCTO:000682(time_t t0) = EVENT_STATE(CCTO:000682, t0) NCI:CTCAE:10065712 NCIT:C78321 UMLS:C1698678 Gastrointestinal stoma necrotic lesion cancer_care_treatment_outcome CCTO:000682 Gastrointestinal stoma necrosis CCTO:000682 A finding of a necrotic process occurring in the gastrointestinal tract stoma OR A necrotic process affecting the post-operative stoma area in the gastrointestinal tract. NCI:CTCAE NCIT:C78321 Gastrointestinal stoma necrotic lesion NCIT:C78321 A traumatic break in one or more of the bones that compose the bony structure of the pelvis OR A finding of traumatic injury to the hip in which the continuity of either the femoral head, femoral neck, intertrochanteric or subtrochanteric regions is broken OR Traumatic or pathological injury to the hip in which the continuity of either the femoral head, femoral neck, intertrochanteric or subtrochanteric regions is broken. Symptoms include pain in the hip or groin, bruising and swelling in and around the hip area. The injured hip is turned outward and the leg appears shorter on that side. CCTO:000683 implies CCTO:000049 CCTO:000683 implies CCTO:001120 CCTO:000683(time_t t0) = EVENT_STATE(CCTO:000683, t0) NCI:CTCAE:10020100 NCIT:C26794 NCIT:C35153 UMLS:C0019557 UMLS:C0149531 Fracture of Pelvis Fracture, hip cancer_care_treatment_outcome CCTO:000683 Hip fracture CCTO:000683 A traumatic break in one or more of the bones that compose the bony structure of the pelvis OR A finding of traumatic injury to the hip in which the continuity of either the femoral head, femoral neck, intertrochanteric or subtrochanteric regions is broken OR Traumatic or pathological injury to the hip in which the continuity of either the femoral head, femoral neck, intertrochanteric or subtrochanteric regions is broken. Symptoms include pain in the hip or groin, bruising and swelling in and around the hip area. The injured hip is turned outward and the leg appears shorter on that side. NCI:CTCAE NCIT:C26794 NCIT:C35153 Fracture of Pelvis NCIT:C35153 Fracture, hip NCIT:C26794 Damage to the carotid artery. Causes include blunt injuries (e.g., motor vehicle accidents and sports-related injuries) and penetrating traumas (e.g., gunshot and knife injuries) OR A finding of damage to the carotid artery. CCTO:000684 implies CCTO:000049 CCTO:000684 implies CCTO:001120 CCTO:000684(time_t t0) = EVENT_STATE(CCTO:000684, t0) NCI:CTCAE:10022161 NCIT:C79599 UMLS:C0160680 cancer_care_treatment_outcome CCTO:000684 Injury to carotid artery CCTO:000684 Damage to the carotid artery. Causes include blunt injuries (e.g., motor vehicle accidents and sports-related injuries) and penetrating traumas (e.g., gunshot and knife injuries) OR A finding of damage to the carotid artery. NCI:CTCAE NCIT:C79599 Damage to the inferior vena cava from traumatic or pathologic processes OR A finding of damage to the inferior vena cava. CCTO:000685 implies CCTO:000049 CCTO:000685 implies CCTO:001120 CCTO:000685(time_t t0) = EVENT_STATE(CCTO:000685, t0) NCI:CTCAE:10022213 NCIT:C78363 UMLS:C0160705 cancer_care_treatment_outcome CCTO:000685 Injury to inferior vena cava CCTO:000685 Damage to the inferior vena cava from traumatic or pathologic processes OR A finding of damage to the inferior vena cava. NCI:CTCAE NCIT:C78363 Damage to the jugular vein from traumatic or pathologic processes OR A finding of damage to the jugular vein. CCTO:000686 implies CCTO:000049 CCTO:000686 implies CCTO:001120 CCTO:000686(time_t t0) = EVENT_STATE(CCTO:000686, t0) NCI:CTCAE:10065849 NCIT:C78364 UMLS:C0347703 cancer_care_treatment_outcome CCTO:000686 Injury to jugular vein CCTO:000686 Damage to the jugular vein from traumatic or pathologic processes OR A finding of damage to the jugular vein. NCI:CTCAE NCIT:C78364 Damage to the superior vena cava from traumatic or pathologic processes OR A finding of damage to the superior vena cava. CCTO:000687 implies CCTO:000049 CCTO:000687 implies CCTO:001120 CCTO:000687(time_t t0) = EVENT_STATE(CCTO:000687, t0) NCI:CTCAE:10022356 NCIT:C78365 UMLS:C0160692 cancer_care_treatment_outcome CCTO:000687 Injury to superior vena cava CCTO:000687 Damage to the superior vena cava from traumatic or pathologic processes OR A finding of damage to the superior vena cava. NCI:CTCAE NCIT:C78365 Leakage of contents from the intestinal stoma OR A finding of leakage of contents from an intestinal stoma (surgically created opening on the surface of the body). CCTO:000688 implies CCTO:000049 CCTO:000688 implies CCTO:001120 CCTO:000688(time_t t0) = EVENT_STATE(CCTO:000688, t0) NCI:CTCAE:10059095 NCIT:C78369 UMLS:C1142488 Intestinal stoma leakage cancer_care_treatment_outcome CCTO:000688 Intestinal stoma leak CCTO:000688 Leakage of contents from the intestinal stoma OR A finding of leakage of contents from an intestinal stoma (surgically created opening on the surface of the body). NCI:CTCAE NCIT:C78369 Intestinal stoma leakage NCIT:C78369 A finding of blockage of the normal flow of the contents of the intestinal stoma OR A blockage of the intestinal stoma. CCTO:000689 implies CCTO:000049 CCTO:000689 implies CCTO:001120 CCTO:000689(time_t t0) = EVENT_STATE(CCTO:000689, t0) NCI:CTCAE:10059094 NCIT:C78370 UMLS:C1142487 cancer_care_treatment_outcome CCTO:000689 Intestinal stoma obstruction CCTO:000689 A finding of blockage of the normal flow of the contents of the intestinal stoma OR A blockage of the intestinal stoma. NCI:CTCAE NCIT:C78370 A finding of blood leakage from the intestinal stoma OR A finding of blood leakage from the intestinal stoma. CCTO:000690 implies CCTO:000049 CCTO:000690 implies CCTO:001120 CCTO:000690(time_t t0) = EVENT_STATE(CCTO:000690, t0) NCI:CTCAE:10049468 NCIT:C78371 UMLS:C0877223 Intestinal stoma site hemorrhage cancer_care_treatment_outcome CCTO:000690 Intestinal stoma site bleeding CCTO:000690 A finding of blood leakage from the intestinal stoma OR A finding of blood leakage from the intestinal stoma. NCI:CTCAE NCIT:C78371 Intestinal stoma site hemorrhage NCIT:C78371 Damage to an artery during a surgical procedure OR A finding of damage to an artery during a surgical procedure. CCTO:000691 implies CCTO:000049 CCTO:000691 implies CCTO:001120 CCTO:000691(time_t t0) = EVENT_STATE(CCTO:000691, t0) NCI:CTCAE:10065826 NCIT:C78375 UMLS:C1698098 cancer_care_treatment_outcome CCTO:000691 Intraoperative arterial injury CCTO:000691 Damage to an artery during a surgical procedure OR A finding of damage to an artery during a surgical procedure. NCI:CTCAE NCIT:C78375 A finding of damage to the breast parenchyma during a surgical procedure OR Damage to the breast parenchyma during a surgical procedure. CCTO:000692 implies CCTO:000049 CCTO:000692 implies CCTO:001120 CCTO:000692(time_t t0) = EVENT_STATE(CCTO:000692, t0) NCI:CTCAE:10065831 NCIT:C78376 UMLS:C1558321 cancer_care_treatment_outcome CCTO:000692 Intraoperative breast injury CCTO:000692 A finding of damage to the breast parenchyma during a surgical procedure OR Damage to the breast parenchyma during a surgical procedure. NCI:CTCAE NCIT:C78376 Damage to the heart during a surgical procedure OR A finding of damage to the heart during a surgical procedure. CCTO:000693 implies CCTO:000049 CCTO:000693 implies CCTO:001120 CCTO:000693(time_t t0) = EVENT_STATE(CCTO:000693, t0) NCI:CTCAE:10065843 NCIT:C78377 UMLS:C1699742 cancer_care_treatment_outcome CCTO:000693 Intraoperative cardiac injury CCTO:000693 Damage to the heart during a surgical procedure OR A finding of damage to the heart during a surgical procedure. NCI:CTCAE NCIT:C78377 A finding of damage to the ear during a surgical procedure OR Damage to the ear during a surgical procedure. CCTO:000694 implies CCTO:000049 CCTO:000694 implies CCTO:001120 CCTO:000694(time_t t0) = EVENT_STATE(CCTO:000694, t0) NCI:CTCAE:10065844 NCIT:C78378 UMLS:C1699211 cancer_care_treatment_outcome CCTO:000694 Intraoperative ear injury CCTO:000694 A finding of damage to the ear during a surgical procedure OR Damage to the ear during a surgical procedure. NCI:CTCAE NCIT:C78378 Damage to an endocrine gland during a surgical procedure OR A finding of damage to the endocrine gland during a surgical procedure. CCTO:000695 implies CCTO:000049 CCTO:000695 implies CCTO:001120 CCTO:000695(time_t t0) = EVENT_STATE(CCTO:000695, t0) NCI:CTCAE:10065834 NCIT:C78379 UMLS:C1699738 cancer_care_treatment_outcome CCTO:000695 Intraoperative endocrine injury CCTO:000695 Damage to an endocrine gland during a surgical procedure OR A finding of damage to the endocrine gland during a surgical procedure. NCI:CTCAE NCIT:C78379 A finding of damage to the gastrointestinal system during a surgical procedure OR Damage to any part of the digestive system during a surgical procedure. CCTO:000696 implies CCTO:000049 CCTO:000696 implies CCTO:001120 CCTO:000696(time_t t0) = EVENT_STATE(CCTO:000696, t0) NCI:CTCAE:10065825 NCIT:C78380 UMLS:C1698097 Intraoperative digestive system injury cancer_care_treatment_outcome CCTO:000696 Intraoperative gastrointestinal injury CCTO:000696 A finding of damage to the gastrointestinal system during a surgical procedure OR Damage to any part of the digestive system during a surgical procedure. NCI:CTCAE NCIT:C78380 Intraoperative digestive system injury NCIT:C78380 Damage to head and neck during a surgical procedure OR A finding of damage to the head and neck during a surgical procedure. CCTO:000697 implies CCTO:000049 CCTO:000697 implies CCTO:001120 CCTO:000697(time_t t0) = EVENT_STATE(CCTO:000697, t0) NCI:CTCAE:10065842 NCIT:C78381 UMLS:C1699741 cancer_care_treatment_outcome CCTO:000697 Intraoperative head and neck injury CCTO:000697 Damage to head and neck during a surgical procedure OR A finding of damage to the head and neck during a surgical procedure. NCI:CTCAE NCIT:C78381 A finding of uncontrolled bleeding during a surgical procedure OR Uncontrolled bleeding during a surgical procedure. CCTO:000698 implies CCTO:000049 CCTO:000698 implies CCTO:001120 CCTO:000698(time_t t0) = EVENT_STATE(CCTO:000698, t0) NCI:CTCAE:10055298 NCIT:C35135 NCIT:C79600 UMLS:C0079027 Operative hemorrhage cancer_care_treatment_outcome CCTO:000698 Intraoperative hemorrhage CCTO:000698 A finding of uncontrolled bleeding during a surgical procedure OR Uncontrolled bleeding during a surgical procedure. NCI:CTCAE NCIT:C35135 Operative hemorrhage NCIT:C35135 A finding of damage to the hepatic parenchyma and/or biliary tract during a surgical procedure OR Damage to the hepatic parenchyma and biliary tract during a surgical procedure. CCTO:000699 implies CCTO:000049 CCTO:000699 implies CCTO:001120 CCTO:000699(time_t t0) = EVENT_STATE(CCTO:000699, t0) NCI:CTCAE:10065827 NCIT:C78382 UMLS:C1699208 cancer_care_treatment_outcome CCTO:000699 Intraoperative hepatobiliary injury CCTO:000699 A finding of damage to the hepatic parenchyma and/or biliary tract during a surgical procedure OR Damage to the hepatic parenchyma and biliary tract during a surgical procedure. NCI:CTCAE NCIT:C78382 Damage to any part of the musculoskeletal system during a surgical procedure OR A finding of damage to the musculoskeletal system during a surgical procedure. CCTO:000700 implies CCTO:000049 CCTO:000700 implies CCTO:001120 CCTO:000700(time_t t0) = EVENT_STATE(CCTO:000700, t0) NCI:CTCAE:10065829 NCIT:C78383 UMLS:C1699209 cancer_care_treatment_outcome CCTO:000700 Intraoperative musculoskeletal injury CCTO:000700 Damage to any part of the musculoskeletal system during a surgical procedure OR A finding of damage to the musculoskeletal system during a surgical procedure. NCI:CTCAE NCIT:C78383 A finding of damage to the nervous system during a surgical procedure OR Damage to any part of the nervous system during a surgical procedure. CCTO:000701 implies CCTO:000049 CCTO:000701 implies CCTO:001120 CCTO:000701(time_t t0) = EVENT_STATE(CCTO:000701, t0) NCI:CTCAE:10065830 NCIT:C78384 UMLS:C1699210 cancer_care_treatment_outcome CCTO:000701 Intraoperative neurological injury CCTO:000701 A finding of damage to the nervous system during a surgical procedure OR Damage to any part of the nervous system during a surgical procedure. NCI:CTCAE NCIT:C78384 Damage to the eye during a surgical procedure OR A finding of damage to the eye during a surgical procedure. CCTO:000702 implies CCTO:000049 CCTO:000702 implies CCTO:001120 CCTO:000702(time_t t0) = EVENT_STATE(CCTO:000702, t0) NCI:CTCAE:10065841 NCIT:C78385 UMLS:C1699740 cancer_care_treatment_outcome CCTO:000702 Intraoperative ocular injury CCTO:000702 Damage to the eye during a surgical procedure OR A finding of damage to the eye during a surgical procedure. NCI:CTCAE NCIT:C78385 Damage to the kidney during a surgical procedure OR A finding of damage to the kidney during a surgical procedure. CCTO:000703 implies CCTO:000049 CCTO:000703 implies CCTO:001120 CCTO:000703(time_t t0) = EVENT_STATE(CCTO:000703, t0) NCI:CTCAE:10065845 NCIT:C78386 UMLS:C1699743 cancer_care_treatment_outcome CCTO:000703 Intraoperative renal injury CCTO:000703 Damage to the kidney during a surgical procedure OR A finding of damage to the kidney during a surgical procedure. NCI:CTCAE NCIT:C78386 A finding of damage to the reproductive organs during a surgical procedure OR Damage to the reproductive organs during a surgical procedure. CCTO:000704 implies CCTO:000049 CCTO:000704 implies CCTO:001120 CCTO:000704(time_t t0) = EVENT_STATE(CCTO:000704, t0) NCI:CTCAE:10065840 NCIT:C78387 UMLS:C1699739 Intraoperative reproductive system injury cancer_care_treatment_outcome CCTO:000704 Intraoperative reproductive tract injury CCTO:000704 A finding of damage to the reproductive organs during a surgical procedure OR Damage to the reproductive organs during a surgical procedure. NCI:CTCAE NCIT:C78387 Intraoperative reproductive system injury NCIT:C78387 Damage to the respiratory system during a surgical procedure OR A finding of damage to the respiratory system during a surgical procedure. CCTO:000705 implies CCTO:000049 CCTO:000705 implies CCTO:001120 CCTO:000705(time_t t0) = EVENT_STATE(CCTO:000705, t0) NCI:CTCAE:10065832 NCIT:C78388 UMLS:C1699737 cancer_care_treatment_outcome CCTO:000705 Intraoperative respiratory injury CCTO:000705 Damage to the respiratory system during a surgical procedure OR A finding of damage to the respiratory system during a surgical procedure. NCI:CTCAE NCIT:C78388 Damage to the skin during a surgical procedure OR A finding of damage to the skin during a surgical procedure. CCTO:000706 implies CCTO:000049 CCTO:000706 implies CCTO:001120 CCTO:000706(time_t t0) = EVENT_STATE(CCTO:000706, t0) NCI:CTCAE:10065846 NCIT:C78389 UMLS:C1558746 cancer_care_treatment_outcome CCTO:000706 Intraoperative skin injury CCTO:000706 Damage to the skin during a surgical procedure OR A finding of damage to the skin during a surgical procedure. NCI:CTCAE NCIT:C78389 Damage to the spleen during a surgical procedure OR A finding of damage to the spleen during a surgical procedure. CCTO:000707 implies CCTO:000049 CCTO:000707 implies CCTO:001120 CCTO:000707(time_t t0) = EVENT_STATE(CCTO:000707, t0) NCI:CTCAE:10065847 NCIT:C78390 UMLS:C1698099 cancer_care_treatment_outcome CCTO:000707 Intraoperative splenic injury CCTO:000707 Damage to the spleen during a surgical procedure OR A finding of damage to the spleen during a surgical procedure. NCI:CTCAE NCIT:C78390 A finding of damage to the urinary system during a surgical procedure OR Damage to any part of the urinary system during a surgical procedure. CCTO:000708 implies CCTO:000049 CCTO:000708 implies CCTO:001120 CCTO:000708(time_t t0) = EVENT_STATE(CCTO:000708, t0) NCI:CTCAE:10065828 NCIT:C78391 UMLS:C1698677 Intraoperative urinary system injury cancer_care_treatment_outcome CCTO:000708 Intraoperative urinary injury CCTO:000708 A finding of damage to the urinary system during a surgical procedure OR Damage to any part of the urinary system during a surgical procedure. NCI:CTCAE NCIT:C78391 Intraoperative urinary system injury NCIT:C78391 A finding of damage to a vein during a surgical procedure OR Damage to a vein during a surgical procedure. CCTO:000709 implies CCTO:000049 CCTO:000709 implies CCTO:001120 CCTO:000709(time_t t0) = EVENT_STATE(CCTO:000709, t0) NCI:CTCAE:10065848 NCIT:C78392 UMLS:C1698100 cancer_care_treatment_outcome CCTO:000709 Intraoperative venous injury CCTO:000709 A finding of damage to a vein during a surgical procedure OR Damage to a vein during a surgical procedure. NCI:CTCAE NCIT:C78392 A finding of leakage of urine due to breakdown of a kidney anastomosis (surgical connection of two separate anatomic structures) OR Leakage of urine due to breakdown of a kidney anastomosis. CCTO:000710 implies CCTO:000049 CCTO:000710 implies CCTO:001120 CCTO:000710(time_t t0) = EVENT_STATE(CCTO:000710, t0) NCI:CTCAE:10065803 NCIT:C78406 UMLS:C1699736 Kidney anastomotic leakage cancer_care_treatment_outcome CCTO:000710 Kidney anastomotic leak CCTO:000710 A finding of leakage of urine due to breakdown of a kidney anastomosis (surgical connection of two separate anatomic structures) OR Leakage of urine due to breakdown of a kidney anastomosis. NCI:CTCAE NCIT:C78406 Kidney anastomotic leakage NCIT:C78406 Leakage due to breakdown of a large intestinal anastomosis OR A finding of leakage due to breakdown of an anastomosis (surgical connection of two separate anatomic structures) in the large intestine. CCTO:000711 implies CCTO:000049 CCTO:000711 implies CCTO:001120 CCTO:000711(time_t t0) = EVENT_STATE(CCTO:000711, t0) NCI:CTCAE:10065891 NCIT:C78408 UMLS:C1699327 Large intestinal anastomotic leakage cancer_care_treatment_outcome CCTO:000711 Large intestinal anastomotic leak CCTO:000711 Leakage due to breakdown of a large intestinal anastomosis OR A finding of leakage due to breakdown of an anastomosis (surgical connection of two separate anatomic structures) in the large intestine. NCI:CTCAE NCIT:C78408 Large intestinal anastomotic leakage NCIT:C78408 Leakage due to breakdown of a pancreatic anastomosis OR A finding of leakage due to breakdown of a pancreatic anastomosis (surgical connection of two separate anatomic structures). CCTO:000712 implies CCTO:000049 CCTO:000712 implies CCTO:001120 CCTO:000712(time_t t0) = EVENT_STATE(CCTO:000712, t0) NCI:CTCAE:10050457 NCIT:C78518 UMLS:C0341498 Pancreatic anastomotic leakage cancer_care_treatment_outcome CCTO:000712 Pancreatic anastomotic leak CCTO:000712 Leakage due to breakdown of a pancreatic anastomosis OR A finding of leakage due to breakdown of a pancreatic anastomosis (surgical connection of two separate anatomic structures). NCI:CTCAE NCIT:C78518 Pancreatic anastomotic leakage NCIT:C78518 A finding of leakage due to breakdown of a pharyngeal anastomosis (surgical connection of two separate anatomic structures) OR Leakage due to breakdown of a pharyngeal anastomosis. CCTO:000713 implies CCTO:000049 CCTO:000713 implies CCTO:001120 CCTO:000713(time_t t0) = EVENT_STATE(CCTO:000713, t0) NCI:CTCAE:10065705 NCIT:C78550 UMLS:C1696702 Pharyngeal anastomotic leakage cancer_care_treatment_outcome CCTO:000713 Pharyngeal anastomotic leak CCTO:000713 A finding of leakage due to breakdown of a pharyngeal anastomosis (surgical connection of two separate anatomic structures) OR Leakage due to breakdown of a pharyngeal anastomosis. NCI:CTCAE NCIT:C78550 Pharyngeal anastomotic leakage NCIT:C78550 A finding of bleeding occurring after a surgical procedure OR Bleeding occurring after completion of a surgical procedure, which may occur immediately or may be delayed, and which may or may not be wound related. CCTO:000714 implies CCTO:000049 CCTO:000714 implies CCTO:001120 CCTO:000714(time_t t0) = EVENT_STATE(CCTO:000714, t0) NCI:CTCAE:10055322 NCIT:C34938 UMLS:C0032788 Postoperative bleeding cancer_care_treatment_outcome CCTO:000714 Postoperative hemorrhage CCTO:000714 A finding of bleeding occurring after a surgical procedure OR Bleeding occurring after completion of a surgical procedure, which may occur immediately or may be delayed, and which may or may not be wound related. NCI:CTCAE NCIT:C34938 Postoperative bleeding NCIT:C34938 Any disorder occurring postoperatively as a consequence of a thoracic procedure OR A finding of a previously undocumented problem that occurs after a thoracic procedure. CCTO:000715 implies CCTO:000049 CCTO:000715 implies CCTO:001120 CCTO:000715(time_t t0) = EVENT_STATE(CCTO:000715, t0) NCI:CTCAE:10056745 NCIT:C78567 UMLS:C1112276 Thoracic procedure postoperative complication cancer_care_treatment_outcome CCTO:000715 Postoperative thoracic procedure complication CCTO:000715 Any disorder occurring postoperatively as a consequence of a thoracic procedure OR A finding of a previously undocumented problem that occurs after a thoracic procedure. NCI:CTCAE NCIT:C78567 Thoracic procedure postoperative complication NCIT:C78567 An intestinal stoma complication characterized by protrusion of the intestine above the abdominal surface OR A finding of protrusion of the intestinal stoma (surgically created opening on the surface of the body) above the abdominal surface. CCTO:000716 implies CCTO:000049 CCTO:000716 implies CCTO:001120 CCTO:000716(time_t t0) = EVENT_STATE(CCTO:000716, t0) NCI:CTCAE:10065745 NCIT:C78570 UMLS:C1699141 Enterostomy prolapse Intestinal stoma prolapse cancer_care_treatment_outcome CCTO:000716 Prolapse of intestinal stoma CCTO:000716 An intestinal stoma complication characterized by protrusion of the intestine above the abdominal surface OR A finding of protrusion of the intestinal stoma (surgically created opening on the surface of the body) above the abdominal surface. NCI:CTCAE NCIT:C78570 Enterostomy prolapse NCIT:C78570 Intestinal stoma prolapse NCIT:C78570 Displacement of the urostomy OR A finding of displacement of the urostomy. CCTO:000717 implies CCTO:000049 CCTO:000717 implies CCTO:001120 CCTO:000717(time_t t0) = EVENT_STATE(CCTO:000717, t0) NCI:CTCAE:10065822 NCIT:C78571 UMLS:C1698096 Urostomy prolapse cancer_care_treatment_outcome CCTO:000717 Prolapse of urostomy CCTO:000717 Displacement of the urostomy OR A finding of displacement of the urostomy. NCI:CTCAE NCIT:C78571 Urostomy prolapse NCIT:C78571 A finding of acute skin inflammatory reaction caused by drugs, especially chemotherapeutic agents, for weeks or months following radiotherapy. The inflammatory reaction is confined to the previously irradiated skin and the symptoms disappear after the removal of the pharmaceutical agent OR Acute skin inflammatory reaction caused by drugs, especially chemotherapeutic agents, weeks or months following radiotherapy. The inflammatory reaction is confined to the previously irradiated skin and the symptoms disappear after the removal of the pharmacologic agent. CCTO:000718 implies CCTO:000049 CCTO:000718 implies CCTO:001120 CCTO:000718(time_t t0) = EVENT_STATE(CCTO:000718, t0) NCI:CTCAE:10037767 NCIT:C78580 UMLS:C1720798 Radiation recall dermatitis Radiation recall reaction (dermatologic) Radiation-recall dermatitis cancer_care_treatment_outcome CCTO:000718 Radiation recall reaction (dermatologic) CCTO:000718 A finding of acute skin inflammatory reaction caused by drugs, especially chemotherapeutic agents, for weeks or months following radiotherapy. The inflammatory reaction is confined to the previously irradiated skin and the symptoms disappear after the removal of the pharmaceutical agent OR Acute skin inflammatory reaction caused by drugs, especially chemotherapeutic agents, weeks or months following radiotherapy. The inflammatory reaction is confined to the previously irradiated skin and the symptoms disappear after the removal of the pharmacologic agent. NCI:CTCAE NCIT:C78580 Radiation recall dermatitis NCIT:C78580 Radiation recall reaction (dermatologic) NCIT:C78580 Radiation-recall dermatitis NCIT:C78580 Leakage due to breakdown of a rectal anastomosis OR A finding of leakage due to breakdown of a rectal anastomosis (surgical connection of two separate anatomic structures). CCTO:000719 implies CCTO:000049 CCTO:000719 implies CCTO:001120 CCTO:000719(time_t t0) = EVENT_STATE(CCTO:000719, t0) NCI:CTCAE:10065894 NCIT:C78583 UMLS:C1698511 Rectal anastomotic leakage cancer_care_treatment_outcome CCTO:000719 Rectal anastomotic leak CCTO:000719 Leakage due to breakdown of a rectal anastomosis OR A finding of leakage due to breakdown of a rectal anastomosis (surgical connection of two separate anatomic structures). NCI:CTCAE NCIT:C78583 Rectal anastomotic leakage NCIT:C78583 A collection of serum in the body OR A finding of tumor-like collection of serum in the tissues. CCTO:000720 implies CCTO:000049 CCTO:000720 implies CCTO:001120 CCTO:000720(time_t t0) = EVENT_STATE(CCTO:000720, t0) NCI:CTCAE:10040102 NCIT:C50739 NCIT:C58401 UMLS:C0262627 UMLS:C1963233 Seroma adverse event cancer_care_treatment_outcome CCTO:000720 Seroma CCTO:000720 A collection of serum in the body OR A finding of tumor-like collection of serum in the tissues. NCI:CTCAE NCIT:C50739 Seroma adverse event NCIT:C58401 A finding of leakage due to breakdown of an anastomosis (surgical connection of two separate anatomic structures) in the small bowel OR Leakage due to breakdown of a small intestinal anastomosis. CCTO:000721 implies CCTO:000049 CCTO:000721 implies CCTO:001120 CCTO:000721(time_t t0) = EVENT_STATE(CCTO:000721, t0) NCI:CTCAE:10065892 NCIT:C78612 UMLS:C1698195 Small intestinal anastomotic leakage cancer_care_treatment_outcome CCTO:000721 Small intestinal anastomotic leak CCTO:000721 A finding of leakage due to breakdown of an anastomosis (surgical connection of two separate anatomic structures) in the small bowel OR Leakage due to breakdown of a small intestinal anastomosis. NCI:CTCAE NCIT:C78612 Small intestinal anastomotic leakage NCIT:C78612 Leakage due to breakdown of a spermatic cord anastomosis OR A finding of leakage due to breakdown of a spermatic cord anastomosis (surgical connection of two separate anatomic structures). CCTO:000722 implies CCTO:000049 CCTO:000722 implies CCTO:001120 CCTO:000722(time_t t0) = EVENT_STATE(CCTO:000722, t0) NCI:CTCAE:10065897 NCIT:C78622 UMLS:C1699328 Spermatic cord anastomotic leakage cancer_care_treatment_outcome CCTO:000722 Spermatic cord anastomotic leak CCTO:000722 Leakage due to breakdown of a spermatic cord anastomosis OR A finding of leakage due to breakdown of a spermatic cord anastomosis (surgical connection of two separate anatomic structures). NCI:CTCAE NCIT:C78622 Spermatic cord anastomotic leakage NCIT:C78622 Traumatic or pathological injury to the spine in which the continuity of a vertebral bone is broken. Symptoms include back pain and difficulty bending and twisting OR A finding of traumatic injury to the spine in which the continuity of a vertebral bone is broken. CCTO:000723 implies CCTO:000049 CCTO:000723 implies CCTO:001120 CCTO:000723(time_t t0) = EVENT_STATE(CCTO:000723, t0) NCI:CTCAE:10041569 NCIT:C80516 UMLS:C0080179 Vertebral fracture cancer_care_treatment_outcome CCTO:000723 Spinal fracture CCTO:000723 Traumatic or pathological injury to the spine in which the continuity of a vertebral bone is broken. Symptoms include back pain and difficulty bending and twisting OR A finding of traumatic injury to the spine in which the continuity of a vertebral bone is broken. NCI:CTCAE NCIT:C80516 Vertebral fracture NCIT:C80516 Narrowing of the lumen of a gastrointestinal stoma OR A finding of narrowing of the gastrointestinal stoma (surgically created opening on the surface of the body). CCTO:000724 implies CCTO:000049 CCTO:000724 implies CCTO:001120 CCTO:000724(time_t t0) = EVENT_STATE(CCTO:000724, t0) NCI:CTCAE:10065898 NCIT:C78628 UMLS:C1699177 Gastrointestinal stoma stenosis cancer_care_treatment_outcome CCTO:000724 Stenosis of gastrointestinal stoma CCTO:000724 Narrowing of the lumen of a gastrointestinal stoma OR A finding of narrowing of the gastrointestinal stoma (surgically created opening on the surface of the body). NCI:CTCAE NCIT:C78628 Gastrointestinal stoma stenosis NCIT:C78628 An ulcer that develops in the jejunal mucosa close to the anastomosis site following a gastroenterostomy procedure OR A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the jejunal mucosal surface close to the anastomosis site following a gastroenterostomy procedure. CCTO:000725 implies CCTO:000049 CCTO:000725 implies CCTO:001120 CCTO:000725(time_t t0) = EVENT_STATE(CCTO:000725, t0) NCI:CTCAE:10042127 NCIT:C79766 UMLS:C0024799 Marginal ulcer cancer_care_treatment_outcome CCTO:000725 Stomal ulcer CCTO:000725 An ulcer that develops in the jejunal mucosa close to the anastomosis site following a gastroenterostomy procedure OR A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the jejunal mucosal surface close to the anastomosis site following a gastroenterostomy procedure. NCI:CTCAE NCIT:C79766 Marginal ulcer NCIT:C79766 A finding of bleeding from the trachea OR Bleeding originating from the trachea. CCTO:000726 implies CCTO:000049 CCTO:000726 implies CCTO:001120 CCTO:000726(time_t t0) = EVENT_STATE(CCTO:000726, t0) NCI:CTCAE:10062548 NCIT:C78642 UMLS:C0340220 cancer_care_treatment_outcome CCTO:000726 Tracheal hemorrhage CCTO:000726 A finding of bleeding from the trachea OR Bleeding originating from the trachea. NCI:CTCAE NCIT:C78642 A finding of blockage of the lumen of the trachea OR Blockage of the lumen of the trachea. Causes include secretions, foreign bodies, and tumors. CCTO:000727 implies CCTO:000049 CCTO:000727 implies CCTO:001120 CCTO:000727(time_t t0) = EVENT_STATE(CCTO:000727, t0) NCI:CTCAE:10044291 NCIT:C78645 UMLS:C0340221 cancer_care_treatment_outcome CCTO:000727 Tracheal obstruction CCTO:000727 A finding of blockage of the lumen of the trachea OR Blockage of the lumen of the trachea. Causes include secretions, foreign bodies, and tumors. NCI:CTCAE NCIT:C78645 A finding of blood leakage from the tracheostomy site OR Bleeding from the tracheostomy site. CCTO:000728 implies CCTO:000049 CCTO:000728 implies CCTO:001120 CCTO:000728(time_t t0) = EVENT_STATE(CCTO:000728, t0) NCI:CTCAE:10065749 NCIT:C78648 UMLS:C1699657 cancer_care_treatment_outcome CCTO:000728 Tracheostomy site bleeding CCTO:000728 A finding of blood leakage from the tracheostomy site OR Bleeding from the tracheostomy site. NCI:CTCAE NCIT:C78648 A finding of leakage due to breakdown of a ureteral anastomosis (surgical connection of two separate anatomic structures) OR Leakage due to breakdown of a ureteral anastomosis. CCTO:000729 implies CCTO:000049 CCTO:000729 implies CCTO:001120 CCTO:000729(time_t t0) = EVENT_STATE(CCTO:000729, t0) NCI:CTCAE:10065814 NCIT:C78662 UMLS:C1698675 Ureteral anastomotic leak Ureteric anastomotic leakage cancer_care_treatment_outcome CCTO:000729 Ureteric anastomotic leak CCTO:000729 A finding of leakage due to breakdown of a ureteral anastomosis (surgical connection of two separate anatomic structures) OR Leakage due to breakdown of a ureteral anastomosis. NCI:CTCAE NCIT:C78662 Ureteral anastomotic leak NCIT:C78662 Ureteric anastomotic leakage NCIT:C78662 A finding of leakage due to breakdown of a urethral anastomosis (surgical connection of two separate anatomic structures) OR Leakage due to breakdown of a urethral anastomosis. CCTO:000730 implies CCTO:000049 CCTO:000730 implies CCTO:001120 CCTO:000730(time_t t0) = EVENT_STATE(CCTO:000730, t0) NCI:CTCAE:10065815 NCIT:C78667 UMLS:C1699207 Urethral anastomotic leakage cancer_care_treatment_outcome CCTO:000730 Urethral anastomotic leak CCTO:000730 A finding of leakage due to breakdown of a urethral anastomosis (surgical connection of two separate anatomic structures) OR Leakage due to breakdown of a urethral anastomosis. NCI:CTCAE NCIT:C78667 Urethral anastomotic leakage NCIT:C78667 A finding of leakage of contents from a urostomy OR Leakage of contents from a urostomy. CCTO:000731 implies CCTO:000049 CCTO:000731 implies CCTO:001120 CCTO:000731(time_t t0) = EVENT_STATE(CCTO:000731, t0) NCI:CTCAE:10065882 NCIT:C78679 UMLS:C1698193 Urostomy leakage cancer_care_treatment_outcome CCTO:000731 Urostomy leak CCTO:000731 A finding of leakage of contents from a urostomy OR Leakage of contents from a urostomy. NCI:CTCAE NCIT:C78679 Urostomy leakage NCIT:C78679 A finding of blockage of the urostomy OR Blockage of the urostomy. CCTO:000732 implies CCTO:000049 CCTO:000732 implies CCTO:001120 CCTO:000732(time_t t0) = EVENT_STATE(CCTO:000732, t0) NCI:CTCAE:10065883 NCIT:C78680 UMLS:C1697984 cancer_care_treatment_outcome CCTO:000732 Urostomy obstruction CCTO:000732 A finding of blockage of the urostomy OR Blockage of the urostomy. NCI:CTCAE NCIT:C78680 A finding of bleeding from the urostomy site OR Hemorrhage from the urostomy site. CCTO:000733 implies CCTO:000049 CCTO:000733 implies CCTO:001120 CCTO:000733(time_t t0) = EVENT_STATE(CCTO:000733, t0) NCI:CTCAE:10065748 NCIT:C78682 UMLS:C1698628 cancer_care_treatment_outcome CCTO:000733 Urostomy site bleeding CCTO:000733 A finding of bleeding from the urostomy site OR Hemorrhage from the urostomy site. NCI:CTCAE NCIT:C78682 Narrowing of the opening of a urostomy OR A finding of narrowing of the opening of a urostomy. CCTO:000734 implies CCTO:000049 CCTO:000734 implies CCTO:001120 CCTO:000734(time_t t0) = EVENT_STATE(CCTO:000734, t0) NCI:CTCAE:10065885 NCIT:C78683 UMLS:C1698769 cancer_care_treatment_outcome CCTO:000734 Urostomy stenosis CCTO:000734 Narrowing of the opening of a urostomy OR A finding of narrowing of the opening of a urostomy. NCI:CTCAE NCIT:C78683 Leakage due to breakdown of a uterine anastomosis OR A finding of leakage due to breakdown of a uterine anastomosis (surgical connection of two separate anatomic structures). CCTO:000735 implies CCTO:000049 CCTO:000735 implies CCTO:001120 CCTO:000735(time_t t0) = EVENT_STATE(CCTO:000735, t0) NCI:CTCAE:10065886 NCIT:C78684 UMLS:C1699812 Uterine anastomotic leakage cancer_care_treatment_outcome CCTO:000735 Uterine anastomotic leak CCTO:000735 Leakage due to breakdown of a uterine anastomosis OR A finding of leakage due to breakdown of a uterine anastomosis (surgical connection of two separate anatomic structures). NCI:CTCAE NCIT:C78684 Uterine anastomotic leakage NCIT:C78684 A rupture in the uterus due to traumatic or pathologic processes OR A disorder characterized by a rupture in the uterine wall. CCTO:000736 implies CCTO:000049 CCTO:000736 implies CCTO:001120 CCTO:000736(time_t t0) = EVENT_STATE(CCTO:000736, t0) NCI:CTCAE:10046810 NCIT:C50793 UMLS:C0042139 UMLS:C1963265 Perforation of uterus Uterus perforation Uterus wall perforation cancer_care_treatment_outcome CCTO:000736 Uterine perforation CCTO:000736 A rupture in the uterus due to traumatic or pathologic processes OR A disorder characterized by a rupture in the uterine wall. NCI:CTCAE NCIT:C50793 Perforation of uterus NCIT:C50793 Uterus perforation NCIT:C50793 Uterus wall perforation NCIT:C50793 Leakage due to breakdown of a vaginal anastomosis OR A finding of leakage due to breakdown of a vaginal anastomosis (surgical connection of two separate anatomic structures). CCTO:000737 implies CCTO:000049 CCTO:000737 implies CCTO:001120 CCTO:000737(time_t t0) = EVENT_STATE(CCTO:000737, t0) NCI:CTCAE:10065887 NCIT:C78698 UMLS:C1698194 Vaginal anastomotic leakage cancer_care_treatment_outcome CCTO:000737 Vaginal anastomotic leak CCTO:000737 Leakage due to breakdown of a vaginal anastomosis OR A finding of leakage due to breakdown of a vaginal anastomosis (surgical connection of two separate anatomic structures). NCI:CTCAE NCIT:C78698 Vaginal anastomotic leakage NCIT:C78698 Leakage due to breakdown of a vas deferens anastomosis OR A finding of leakage due to breakdown of a vas deferens anastomosis (surgical connection of two separate anatomic structures). CCTO:000738 implies CCTO:000049 CCTO:000738 implies CCTO:001120 CCTO:000738(time_t t0) = EVENT_STATE(CCTO:000738, t0) NCI:CTCAE:10065888 NCIT:C78704 UMLS:C1699326 Vas deferens anastomotic leakage cancer_care_treatment_outcome CCTO:000738 Vas deferens anastomotic leak CCTO:000738 Leakage due to breakdown of a vas deferens anastomosis OR A finding of leakage due to breakdown of a vas deferens anastomosis (surgical connection of two separate anatomic structures). NCI:CTCAE NCIT:C78704 Vas deferens anastomotic leakage NCIT:C78704 Complications related to damage at the vascular access site. Examples include bleeding, formation of hematoma, aneurysm, pseudoaneurysm, or arteriovenous fistula, development of infection, and catheter thrombosis OR A finding of a previously undocumented problem related to the vascular access site. CCTO:000739 implies CCTO:000049 CCTO:000739 implies CCTO:001120 CCTO:000739(time_t t0) = EVENT_STATE(CCTO:000739, t0) NCI:CTCAE:10062169 NCIT:C78709 UMLS:C0920165 cancer_care_treatment_outcome CCTO:000739 Vascular access complication CCTO:000739 Complications related to damage at the vascular access site. Examples include bleeding, formation of hematoma, aneurysm, pseudoaneurysm, or arteriovenous fistula, development of infection, and catheter thrombosis OR A finding of a previously undocumented problem related to the vascular access site. NCI:CTCAE NCIT:C78709 A finding of damage to a vein OR Damage to a vein from traumatic or pathologic processes. CCTO:000740 implies CCTO:000049 CCTO:000740 implies CCTO:001120 CCTO:000740(time_t t0) = EVENT_STATE(CCTO:000740, t0) NCI:CTCAE:10047228 NCIT:C78711 UMLS:C0340770 cancer_care_treatment_outcome CCTO:000740 Venous injury CCTO:000740 A finding of damage to a vein OR Damage to a vein from traumatic or pathologic processes. NCI:CTCAE NCIT:C78711 A medical condition that develops at the site of an existing wound. Examples include swelling, draining, bleeding, formation of hematoma, infection, and necrosis OR A finding of development of a new problem at the site of an existing wound. CCTO:000741 implies CCTO:000049 CCTO:000741 implies CCTO:001120 CCTO:000741(time_t t0) = EVENT_STATE(CCTO:000741, t0) NCI:CTCAE:10053692 NCIT:C78719 UMLS:C1096106 Wound healing complication Wound healing disorder cancer_care_treatment_outcome CCTO:000741 Wound complication CCTO:000741 A medical condition that develops at the site of an existing wound. Examples include swelling, draining, bleeding, formation of hematoma, infection, and necrosis OR A finding of development of a new problem at the site of an existing wound. NCI:CTCAE NCIT:C78719 Wound healing complication NCIT:C78719 Wound healing disorder NCIT:C78719 A finding of separation of the approximated margins of a surgical wound OR Splitting of the sutured margins of a surgical wound. Risk factors include diabetes mellitus, obesity, and advanced age. CCTO:000742 implies CCTO:000049 CCTO:000742 implies CCTO:001120 CCTO:000742(time_t t0) = EVENT_STATE(CCTO:000742, t0) NCI:CTCAE:10048031 NCIT:C50863 UMLS:C0259768 Dehiscence wound Wound disruption cancer_care_treatment_outcome CCTO:000742 Wound dehiscence CCTO:000742 A finding of separation of the approximated margins of a surgical wound OR Splitting of the sutured margins of a surgical wound. Risk factors include diabetes mellitus, obesity, and advanced age. NCI:CTCAE NCIT:C50863 Dehiscence wound NCIT:C50863 Wound disruption NCIT:C50863 Traumatic injury to the wrist joint in which the continuity of a wrist bone is broken. Symptoms include wrist pain, swelling, and deformity of wrist OR A finding of traumatic injury to the wrist joint in which the continuity of a wrist bone is broken. CCTO:000743 implies CCTO:000049 CCTO:000743 implies CCTO:001120 CCTO:000743(time_t t0) = EVENT_STATE(CCTO:000743, t0) NCI:CTCAE:10048049 NCIT:C80517 UMLS:C0435630 cancer_care_treatment_outcome CCTO:000743 Wrist fracture CCTO:000743 Traumatic injury to the wrist joint in which the continuity of a wrist bone is broken. Symptoms include wrist pain, swelling, and deformity of wrist OR A finding of traumatic injury to the wrist joint in which the continuity of a wrist bone is broken. NCI:CTCAE NCIT:C80517 An abnormal laboratory test result in which the partial thromboplastin time is found to be greater than the control value. As a possible indicator of coagulopathy, a prolonged partial thromboplastin time (PTT) may occur in a variety of diseases and disorders, both primary and related to treatment OR An abnormal laboratory test result in which the partial thromboplastin time is found to be greater than the control value. As a possible indicator of coagulopathy, a prolonged partial thromboplastin time (PTT) may occur in a variety of diseases and disorders, both primary and related to treatment. CCTO:000744 implies CCTO:000049 CCTO:000744 implies CCTO:000051 CCTO:000744(time_t t0) = EVENT_STATE(CCTO:000744, t0) NCI:CTCAE:10000636 NCIT:C27028 UMLS:C0240671 Prolonged activated partial thromboplastin time Prolonged partial thromboplastin time cancer_care_treatment_outcome CCTO:000744 Activated partial thromboplastin time prolonged CCTO:000744 An abnormal laboratory test result in which the partial thromboplastin time is found to be greater than the control value. As a possible indicator of coagulopathy, a prolonged partial thromboplastin time (PTT) may occur in a variety of diseases and disorders, both primary and related to treatment OR An abnormal laboratory test result in which the partial thromboplastin time is found to be greater than the control value. As a possible indicator of coagulopathy, a prolonged partial thromboplastin time (PTT) may occur in a variety of diseases and disorders, both primary and related to treatment. NCI:CTCAE NCIT:C27028 Prolonged activated partial thromboplastin time NCIT:C27028 Prolonged partial thromboplastin time NCIT:C27028 A finding based on laboratory test results that indicate an increase in the level of alanine aminotransferase (ALT or SGPT) in the blood specimen OR An increase in the level of alanine aminotransferase in the blood. CCTO:000745 implies CCTO:000049 CCTO:000745 implies CCTO:000051 CCTO:000745(time_t t0) = EVENT_STATE(CCTO:000745, t0) NCI:CTCAE:10001551 NCIT:C26948 UMLS:C0151905 cancer_care_treatment_outcome CCTO:000745 Alanine aminotransferase increased CCTO:000745 A finding based on laboratory test results that indicate an increase in the level of alanine aminotransferase (ALT or SGPT) in the blood specimen OR An increase in the level of alanine aminotransferase in the blood. NCI:CTCAE NCIT:C26948 A laboratory test result which indicates an increased level of alkaline phosphatase in a biological specimen OR A finding based on laboratory test results that indicate an increase in the level of alkaline phosphatase in a blood specimen. CCTO:000746 implies CCTO:000049 CCTO:000746 implies CCTO:000051 CCTO:000746(time_t t0) = EVENT_STATE(CCTO:000746, t0) NCI:CTCAE:10001675 NCIT:C35607 UMLS:C0151849 UMLS:C0852911 Blood alkaline phosphatase increased cancer_care_treatment_outcome CCTO:000746 Alkaline phosphatase increased CCTO:000746 A laboratory test result which indicates an increased level of alkaline phosphatase in a biological specimen OR A finding based on laboratory test results that indicate an increase in the level of alkaline phosphatase in a blood specimen. NCI:CTCAE NCIT:C35607 Blood alkaline phosphatase increased NCIT:C35607 An increase in the level of aspartate aminotransferase in the blood OR A finding based on laboratory test results that indicate an increase in the level of aspartate aminotransferase (AST or SGOT) in a blood specimen. CCTO:000747 implies CCTO:000049 CCTO:000747 implies CCTO:000051 CCTO:000747(time_t t0) = EVENT_STATE(CCTO:000747, t0) NCI:CTCAE:10003481 NCIT:C26947 UMLS:C0151904 cancer_care_treatment_outcome CCTO:000747 Aspartate aminotransferase increased CCTO:000747 An increase in the level of aspartate aminotransferase in the blood OR A finding based on laboratory test results that indicate an increase in the level of aspartate aminotransferase (AST or SGOT) in a blood specimen. NCI:CTCAE NCIT:C26947 A finding based on laboratory test results that indicate abnormal levels of antidiuretic hormone in the blood specimen OR A laboratory test result which indicates abnormal levels of antidiuretic hormone in the blood. CCTO:000748 implies CCTO:000049 CCTO:000748 implies CCTO:000051 CCTO:000748(time_t t0) = EVENT_STATE(CCTO:000748, t0) NCI:CTCAE:10005332 NCIT:C78214 UMLS:C0853592 Abnormal blood antidiuretic hormone cancer_care_treatment_outcome CCTO:000748 Blood antidiuretic hormone abnormal CCTO:000748 A finding based on laboratory test results that indicate abnormal levels of antidiuretic hormone in the blood specimen OR A laboratory test result which indicates abnormal levels of antidiuretic hormone in the blood. NCI:CTCAE NCIT:C78214 Abnormal blood antidiuretic hormone NCIT:C78214 Abnormally high level of bilirubin in the blood. Excess bilirubin is associated with jaundice OR A finding based on laboratory test results that indicate an abnormally high level of bilirubin in the blood. Excess bilirubin is associated with jaundice. CCTO:000749 implies CCTO:000049 CCTO:000749 implies CCTO:000051 CCTO:000749(time_t t0) = EVENT_STATE(CCTO:000749, t0) NCI:CTCAE:10005364 NCIT:C27088 UMLS:C0020433 UMLS:C0311468 Hyperbilirubinemia cancer_care_treatment_outcome CCTO:000749 Blood bilirubin increased CCTO:000749 Abnormally high level of bilirubin in the blood. Excess bilirubin is associated with jaundice OR A finding based on laboratory test results that indicate an abnormally high level of bilirubin in the blood. Excess bilirubin is associated with jaundice. NCI:CTCAE NCIT:C27088 Hyperbilirubinemia NCIT:C27088 A laboratory test result which indicates decreased levels of corticotrophin in the blood OR A finding based on laboratory test results that indicate an decrease in levels of corticotrophin in a blood specimen. CCTO:000750 implies CCTO:000049 CCTO:000750 implies CCTO:000051 CCTO:000750(time_t t0) = EVENT_STATE(CCTO:000750, t0) NCI:CTCAE:10005452 NCIT:C78215 UMLS:C0853122 cancer_care_treatment_outcome CCTO:000750 Blood corticotrophin decreased CCTO:000750 A laboratory test result which indicates decreased levels of corticotrophin in the blood OR A finding based on laboratory test results that indicate an decrease in levels of corticotrophin in a blood specimen. NCI:CTCAE NCIT:C78215 A laboratory test result which indicates abnormal levels of gonadotrophin hormone in the blood OR A finding based on laboratory test results that indicate abnormal levels of gonadotrophin hormone in a blood specimen. CCTO:000751 implies CCTO:000049 CCTO:000751 implies CCTO:000051 CCTO:000751(time_t t0) = EVENT_STATE(CCTO:000751, t0) NCI:CTCAE:10005561 NCIT:C78216 UMLS:C0853603 Abnormal blood gonadotrophin cancer_care_treatment_outcome CCTO:000751 Blood gonadotrophin abnormal CCTO:000751 A laboratory test result which indicates abnormal levels of gonadotrophin hormone in the blood OR A finding based on laboratory test results that indicate abnormal levels of gonadotrophin hormone in a blood specimen. NCI:CTCAE NCIT:C78216 Abnormal blood gonadotrophin NCIT:C78216 A finding based on laboratory test results that indicate abnormal levels of prolactin hormone in a blood specimen OR A laboratory test result which indicates abnormal levels of prolactin hormone in the blood. CCTO:000752 implies CCTO:000049 CCTO:000752 implies CCTO:000051 CCTO:000752(time_t t0) = EVENT_STATE(CCTO:000752, t0) NCI:CTCAE:10005778 NCIT:C78217 UMLS:C0853620 Abnormal blood prolactin cancer_care_treatment_outcome CCTO:000752 Blood prolactin abnormal CCTO:000752 A finding based on laboratory test results that indicate abnormal levels of prolactin hormone in a blood specimen OR A laboratory test result which indicates abnormal levels of prolactin hormone in the blood. NCI:CTCAE NCIT:C78217 Abnormal blood prolactin NCIT:C78217 A finding based on lung function test results that indicate a decrease in the lung capacity to absorb carbon monoxide OR A lung function test result in which the lung capacity to absorb carbon monoxide is decreased. CCTO:000753 implies CCTO:000049 CCTO:000753 implies CCTO:000051 CCTO:000753(time_t t0) = EVENT_STATE(CCTO:000753, t0) NCI:CTCAE:10065906 NCIT:C78229 UMLS:C1697788 Decreased carbon monoxide diffusing capacity cancer_care_treatment_outcome CCTO:000753 Carbon monoxide diffusing capacity decreased CCTO:000753 A finding based on lung function test results that indicate a decrease in the lung capacity to absorb carbon monoxide OR A lung function test result in which the lung capacity to absorb carbon monoxide is decreased. NCI:CTCAE NCIT:C78229 Decreased carbon monoxide diffusing capacity NCIT:C78229 A laboratory test result which indicates increased levels of cardiac troponin I in a biological specimen OR A laboratory test result which indicates increased levels of cardiac troponin I in a biological specimen. CCTO:000754 implies CCTO:000049 CCTO:000754 implies CCTO:000051 CCTO:000754(time_t t0) = EVENT_STATE(CCTO:000754, t0) NCI:CTCAE:10007612 NCIT:C78230 UMLS:C0852692 Blood Cardiac Troponin I Increased cancer_care_treatment_outcome CCTO:000754 Cardiac troponin I increased CCTO:000754 A laboratory test result which indicates increased levels of cardiac troponin I in a biological specimen OR A laboratory test result which indicates increased levels of cardiac troponin I in a biological specimen. NCI:CTCAE NCIT:C78230 Blood Cardiac Troponin I Increased NCIT:C78230 A laboratory test result which indicates increased levels of cardiac troponin T in a biological specimen OR A laboratory test result which indicates increased levels of cardiac troponin T in a biological specimen. CCTO:000755 implies CCTO:000049 CCTO:000755 implies CCTO:000051 CCTO:000755(time_t t0) = EVENT_STATE(CCTO:000755, t0) NCI:CTCAE:10007613 NCIT:C78231 UMLS:C0852680 Blood Cardiac Troponin T Increased cancer_care_treatment_outcome CCTO:000755 Cardiac troponin T increased CCTO:000755 A laboratory test result which indicates increased levels of cardiac troponin T in a biological specimen OR A laboratory test result which indicates increased levels of cardiac troponin T in a biological specimen. NCI:CTCAE NCIT:C78231 Blood Cardiac Troponin T Increased NCIT:C78231 A finding based on laboratory test results that indicate an decrease in levels of CD4 lymphocytes in a blood specimen OR A laboratory test result which indicates decreased levels of CD4 lymphocytes in a biospecimen. CCTO:000756 implies CCTO:000049 CCTO:000756 implies CCTO:000051 CCTO:000756(time_t t0) = EVENT_STATE(CCTO:000756, t0) NCI:CTCAE:10007839 NCIT:C78233 UMLS:C0853142 cancer_care_treatment_outcome CCTO:000756 CD4 lymphocytes decreased CCTO:000756 A finding based on laboratory test results that indicate an decrease in levels of CD4 lymphocytes in a blood specimen OR A laboratory test result which indicates decreased levels of CD4 lymphocytes in a biospecimen. NCI:CTCAE NCIT:C78233 A finding based on laboratory test results that indicate higher than normal levels of cholesterol in a blood specimen OR A laboratory test result indicating an increased amount of cholesterol in the blood. CCTO:000757 implies CCTO:000049 CCTO:000757 implies CCTO:000051 CCTO:000757(time_t t0) = EVENT_STATE(CCTO:000757, t0) NCI:CTCAE:10008661 NCIT:C37967 UMLS:C0020443 UMLS:C1522133 High cholesterol Hypercholesterolemia cancer_care_treatment_outcome CCTO:000757 Cholesterol high CCTO:000757 A finding based on laboratory test results that indicate higher than normal levels of cholesterol in a blood specimen OR A laboratory test result indicating an increased amount of cholesterol in the blood. NCI:CTCAE NCIT:C37967 High cholesterol NCIT:C37967 Hypercholesterolemia NCIT:C37967 A finding based on laboratory test results that indicate an increase in levels of creatine phosphokinase in a blood specimen OR A laboratory test result which indicates increased levels of creatine phosphokinase in a biological specimen. CCTO:000758 implies CCTO:000049 CCTO:000758 implies CCTO:000051 CCTO:000758(time_t t0) = EVENT_STATE(CCTO:000758, t0) NCI:CTCAE:10011268 NCIT:C78247 UMLS:C0151576 Creatine phosphokinase increased cancer_care_treatment_outcome CCTO:000758 CPK increased CCTO:000758 A finding based on laboratory test results that indicate an increase in levels of creatine phosphokinase in a blood specimen OR A laboratory test result which indicates increased levels of creatine phosphokinase in a biological specimen. NCI:CTCAE NCIT:C78247 Creatine phosphokinase increased NCIT:C78247 A finding based on laboratory test results that indicate increased levels of creatinine in a biological specimen OR A laboratory test result demonstrating an increased concentration of creatinine in a biological specimen. CCTO:000759 implies CCTO:000049 CCTO:000759 implies CCTO:000051 CCTO:000759(time_t t0) = EVENT_STATE(CCTO:000759, t0) NCI:CTCAE:10011368 NCIT:C78249 UMLS:C0151578 Elevated creatinine Increased creatinine cancer_care_treatment_outcome CCTO:000759 Creatinine increased CCTO:000759 A finding based on laboratory test results that indicate increased levels of creatinine in a biological specimen OR A laboratory test result demonstrating an increased concentration of creatinine in a biological specimen. NCI:CTCAE NCIT:C78249 Elevated creatinine NCIT:C78249 Increased creatinine NCIT:C78249 A finding indicating a decrease in the volume of blood ejected during ventricular heart contraction OR The percentage computed when the amount of blood ejected during a ventricular contraction of the heart is compared to the amount that was present prior to the contraction. CCTO:000760 implies CCTO:000049 CCTO:000760 implies CCTO:000051 CCTO:000760(time_t t0) = EVENT_STATE(CCTO:000760, t0) NCI:CTCAE:10050528 NCIT:C83492 UMLS:C0743400 cancer_care_treatment_outcome CCTO:000760 Ejection fraction decreased CCTO:000760 A finding indicating a decrease in the volume of blood ejected during ventricular heart contraction OR The percentage computed when the amount of blood ejected during a ventricular contraction of the heart is compared to the amount that was present prior to the contraction. NCI:CTCAE NCIT:C83492 A finding of a cardiac dysrhythmia characterized by an abnormally long corrected QT interval OR An electrocardiographic finding in which the QTc interval corrected for heart rate is prolonged. Thresholds for different age, gender, and patient populations exist. (CDISC) CCTO:000761 implies CCTO:000049 CCTO:000761 implies CCTO:000051 CCTO:000761(time_t t0) = EVENT_STATE(CCTO:000761, t0) NCI:CTCAE:10014383 NCIT:C83817 UMLS:C0855333 Corrected Prolonged QT Interval Corrected Prolonged QT Interval by ECG Finding Corrected Prolonged QT Interval by EKG Finding QTc Prolongation cancer_care_treatment_outcome CCTO:000761 Electrocardiogram QT corrected interval prolonged CCTO:000761 A finding of a cardiac dysrhythmia characterized by an abnormally long corrected QT interval OR An electrocardiographic finding in which the QTc interval corrected for heart rate is prolonged. Thresholds for different age, gender, and patient populations exist. (CDISC) NCI:CTCAE NCIT:C83817 Corrected Prolonged QT Interval NCIT:C83817 Corrected Prolonged QT Interval by ECG Finding NCIT:C83817 Corrected Prolonged QT Interval by EKG Finding NCIT:C83817 QTc Prolongation NCIT:C83817 A finding based on laboratory test results that indicate an decrease in levels of fibrinogen in a blood specimen OR A laboratory test result which indicates decreased levels of fibrinogen in a biological specimen. CCTO:000762 implies CCTO:000049 CCTO:000762 implies CCTO:000051 CCTO:000762(time_t t0) = EVENT_STATE(CCTO:000762, t0) NCI:CTCAE:10016596 NCIT:C78300 UMLS:C1295715 cancer_care_treatment_outcome CCTO:000762 Fibrinogen decreased CCTO:000762 A finding based on laboratory test results that indicate an decrease in levels of fibrinogen in a blood specimen OR A laboratory test result which indicates decreased levels of fibrinogen in a biological specimen. NCI:CTCAE NCIT:C78300 A decrease in the fraction of the forced vital capacity that is exhaled in a specific number of seconds OR A finding based on test results that indicate a relative decrease in the fraction of the forced vital capacity that is exhaled in a specific number of seconds. CCTO:000763 implies CCTO:000049 CCTO:000763 implies CCTO:000051 CCTO:000763(time_t t0) = EVENT_STATE(CCTO:000763, t0) NCI:CTCAE:10016987 NCIT:C50524 UMLS:C0520837 Decreased Forced Expiratory Volume (FEV) Decreased forced expiratory volume FEV (Forced Expiratory Volume), Decreased FEV Decreased Forced Expiratory Volume (FEV), Decreased Forced expiratory volume, decreased Volume (FEV), Decreased Forced Expiratory cancer_care_treatment_outcome CCTO:000763 Forced expiratory volume decreased CCTO:000763 A decrease in the fraction of the forced vital capacity that is exhaled in a specific number of seconds OR A finding based on test results that indicate a relative decrease in the fraction of the forced vital capacity that is exhaled in a specific number of seconds. NCI:CTCAE NCIT:C50524 Decreased Forced Expiratory Volume (FEV) NCIT:C50524 Decreased forced expiratory volume NCIT:C50524 FEV (Forced Expiratory Volume), Decreased NCIT:C50524 FEV Decreased NCIT:C50524 Forced Expiratory Volume (FEV), Decreased NCIT:C50524 Forced expiratory volume, decreased NCIT:C50524 Volume (FEV), Decreased Forced Expiratory NCIT:C50524 Increase in the level of the enzyme gamma-glutamyltransferase in the blood, which catalyzes the transfer of a gamma glutamyl group from a gamma glutamyl peptide to another peptide, aminoacids, or water OR A finding based on laboratory test results that indicate higher than normal levels of the enzyme gamma-glutamyltransferase in the blood specimen. GGT (gamma-glutamyltransferase ) catalyzes the transfer of a gamma glutamyl group from a gamma glutamyl peptide to another peptide, amino acids or water. CCTO:000764 implies CCTO:000049 CCTO:000764 implies CCTO:000051 CCTO:000764(time_t t0) = EVENT_STATE(CCTO:000764, t0) NCI:CTCAE:10056910 NCIT:C26943 UMLS:C0151662 Gamma-glutamyltransferase increased cancer_care_treatment_outcome CCTO:000764 GGT increased CCTO:000764 Increase in the level of the enzyme gamma-glutamyltransferase in the blood, which catalyzes the transfer of a gamma glutamyl group from a gamma glutamyl peptide to another peptide, aminoacids, or water OR A finding based on laboratory test results that indicate higher than normal levels of the enzyme gamma-glutamyltransferase in the blood specimen. GGT (gamma-glutamyltransferase ) catalyzes the transfer of a gamma glutamyl group from a gamma glutamyl peptide to another peptide, amino acids or water. NCI:CTCAE NCIT:C26943 Gamma-glutamyltransferase increased NCIT:C26943 A laboratory test result which indicates abnormal levels of growth hormone in a biologic specimen OR A finding based on laboratory test results that indicate abnormal levels of growth hormone in a biological specimen. CCTO:000765 implies CCTO:000049 CCTO:000765 implies CCTO:000051 CCTO:000765(time_t t0) = EVENT_STATE(CCTO:000765, t0) NCI:CTCAE:10018748 NCIT:C78327 UMLS:C0860787 Abnormal growth hormone cancer_care_treatment_outcome CCTO:000765 Growth hormone abnormal CCTO:000765 A laboratory test result which indicates abnormal levels of growth hormone in a biologic specimen OR A finding based on laboratory test results that indicate abnormal levels of growth hormone in a biological specimen. NCI:CTCAE NCIT:C78327 Abnormal growth hormone NCIT:C78327 A finding based on laboratory test results that indicate an decrease in levels of haptoglobin in a blood specimen OR A laboratory test result which indicates decreased levels of haptoglobin in a biological specimen. CCTO:000766 implies CCTO:000049 CCTO:000766 implies CCTO:000051 CCTO:000766(time_t t0) = EVENT_STATE(CCTO:000766, t0) NCI:CTCAE:10019150 NCIT:C78330 UMLS:C0236062 cancer_care_treatment_outcome CCTO:000766 Haptoglobin decreased CCTO:000766 A finding based on laboratory test results that indicate an decrease in levels of haptoglobin in a blood specimen OR A laboratory test result which indicates decreased levels of haptoglobin in a biological specimen. NCI:CTCAE NCIT:C78330 A laboratory test result which indicates increased levels of hemoglobin in a biological specimen OR A finding based on laboratory test results that indicate increased levels of hemoglobin in a biological specimen. CCTO:000767 implies CCTO:000049 CCTO:000767 implies CCTO:000051 CCTO:000767(time_t t0) = EVENT_STATE(CCTO:000767, t0) NCI:CTCAE:10055599 NCIT:C78333 UMLS:C0549448 cancer_care_treatment_outcome CCTO:000767 Hemoglobin increased CCTO:000767 A laboratory test result which indicates increased levels of hemoglobin in a biological specimen OR A finding based on laboratory test results that indicate increased levels of hemoglobin in a biological specimen. NCI:CTCAE NCIT:C78333 A finding based on laboratory test results that indicate an increase in the ratio of the patient's prothrombin time to a control sample in the blood OR A laboratory test result demonstrating an increased ratio of the patient's prothrombin time to a control sample. CCTO:000768 implies CCTO:000049 CCTO:000768 implies CCTO:000051 CCTO:000768(time_t t0) = EVENT_STATE(CCTO:000768, t0) NCI:CTCAE:10022402 NCIT:C78366 UMLS:C0853225 Elevated prothrombin time international normalized ratio International normalized ratio increased Supratherapeutic international normalized ratio cancer_care_treatment_outcome CCTO:000768 INR increased CCTO:000768 A finding based on laboratory test results that indicate an increase in the ratio of the patient's prothrombin time to a control sample in the blood OR A laboratory test result demonstrating an increased ratio of the patient's prothrombin time to a control sample. NCI:CTCAE NCIT:C78366 Elevated prothrombin time international normalized ratio NCIT:C78366 International normalized ratio increased NCIT:C78366 Supratherapeutic international normalized ratio NCIT:C78366 A laboratory test result which indicates increased levels of lipase in a biologic specimen OR A finding based on laboratory test results that indicate an increase in the level of lipase in a biological specimen. CCTO:000769 implies CCTO:000049 CCTO:000769 implies CCTO:000051 CCTO:000769(time_t t0) = EVENT_STATE(CCTO:000769, t0) NCI:CTCAE:10024574 NCIT:C78435 UMLS:C0549475 UMLS:C1963823 Elevated lipase Hyperlipasemia cancer_care_treatment_outcome CCTO:000769 Lipase increased CCTO:000769 A laboratory test result which indicates increased levels of lipase in a biologic specimen OR A finding based on laboratory test results that indicate an increase in the level of lipase in a biological specimen. NCI:CTCAE NCIT:C78435 Elevated lipase NCIT:C78435 Hyperlipasemia NCIT:C78435 A finding based on laboratory test results that indicate a decrease in number of lymphocytes in a blood specimen OR An abnormally small number of lymphocytes in the circulating blood. CCTO:000770 implies CCTO:000049 CCTO:000770 implies CCTO:000051 CCTO:000770(time_t t0) = EVENT_STATE(CCTO:000770, t0) NCI:CTCAE:10025256 NCIT:C26823 UMLS:C0024312 UMLS:C0853986 Lymphocytopenia Lymphopenia lymphocytic leukopenia cancer_care_treatment_outcome CCTO:000770 Lymphocyte count decreased CCTO:000770 A finding based on laboratory test results that indicate a decrease in number of lymphocytes in a blood specimen OR An abnormally small number of lymphocytes in the circulating blood. NCI:CTCAE NCIT:C26823 Lymphocytopenia NCIT:C26823 Lymphopenia NCIT:C26823 lymphocytic leukopenia NCIT:C26823 A finding based on laboratory test results that indicate an abnormal increase in the number of lymphocytes in the blood, effusions or bone marrow OR A laboratory test result indicating an abnormal increase in the number of lymphocytes in the peripheral blood, effusions, or bone marrow. CCTO:000771 implies CCTO:000049 CCTO:000771 implies CCTO:000051 CCTO:000771(time_t t0) = EVENT_STATE(CCTO:000771, t0) NCI:CTCAE:10025258 NCIT:C34791 UMLS:C0024282 UMLS:C0853698 Lymphocytosis cancer_care_treatment_outcome CCTO:000771 Lymphocyte count increased CCTO:000771 A finding based on laboratory test results that indicate an abnormal increase in the number of lymphocytes in the blood, effusions or bone marrow OR A laboratory test result indicating an abnormal increase in the number of lymphocytes in the peripheral blood, effusions, or bone marrow. NCI:CTCAE NCIT:C34791 Lymphocytosis NCIT:C34791 A finding based on laboratory test results that indicate a decrease in number of neutrophils in a blood specimen OR A decrease in the number of neutrophils in the peripheral blood. CCTO:000772 implies CCTO:000049 CCTO:000772 implies CCTO:000051 CCTO:000772(time_t t0) = EVENT_STATE(CCTO:000772, t0) NCI:CTCAE:10029366 NCIT:C80520 UMLS:C0001824 UMLS:C0023530 UMLS:C0027947 UMLS:C0853697 Granulocytopenia Neutropenia cancer_care_treatment_outcome CCTO:000772 Neutrophil count decreased CCTO:000772 A finding based on laboratory test results that indicate a decrease in number of neutrophils in a blood specimen OR A decrease in the number of neutrophils in the peripheral blood. NCI:CTCAE NCIT:C80520 Granulocytopenia NCIT:C80520 Neutropenia NCIT:C80520 A finding based on laboratory test results that indicate an decrease in levels of pancreatic enzymes in a biological specimen OR A laboratory test result which indicates decreased levels of pancreatic enzymes in a biologic specimen. CCTO:000773 implies CCTO:000049 CCTO:000773 implies CCTO:000051 CCTO:000773(time_t t0) = EVENT_STATE(CCTO:000773, t0) NCI:CTCAE:10062646 NCIT:C78520 UMLS:C0549370 cancer_care_treatment_outcome CCTO:000773 Pancreatic enzymes decreased CCTO:000773 A finding based on laboratory test results that indicate an decrease in levels of pancreatic enzymes in a biological specimen OR A laboratory test result which indicates decreased levels of pancreatic enzymes in a biologic specimen. NCI:CTCAE NCIT:C78520 A finding based on laboratory test results that indicate a decrease in number of platelets in a blood specimen OR A laboratory test result indicating that there is an abnormally small number of platelets in the circulating blood. CCTO:000774 implies CCTO:000049 CCTO:000774 implies CCTO:000051 CCTO:000774(time_t t0) = EVENT_STATE(CCTO:000774, t0) NCI:CTCAE:10035528 NCIT:C3408 UMLS:C0040034 UMLS:C0392386 Thrombocytopenia Thrombocytopenic disorder cancer_care_treatment_outcome CCTO:000774 Platelet count decreased CCTO:000774 A finding based on laboratory test results that indicate a decrease in number of platelets in a blood specimen OR A laboratory test result indicating that there is an abnormally small number of platelets in the circulating blood. NCI:CTCAE NCIT:C3408 Thrombocytopenia NCIT:C3408 Thrombocytopenic disorder NCIT:C3408 A finding based on laboratory test results that indicate an increase in the levels of amylase in a serum specimen OR A laboratory test indicating increased levels of amylase in the serum. CCTO:000775 implies CCTO:000049 CCTO:000775 implies CCTO:000051 CCTO:000775(time_t t0) = EVENT_STATE(CCTO:000775, t0) NCI:CTCAE:10040139 NCIT:C78608 UMLS:C0476327 cancer_care_treatment_outcome CCTO:000775 Serum amylase increased CCTO:000775 A finding based on laboratory test results that indicate an increase in the levels of amylase in a serum specimen OR A laboratory test indicating increased levels of amylase in the serum. NCI:CTCAE NCIT:C78608 A finding based on test results that indicate urine production is less relative to previous output OR A finding indicating that the urine production is less than 500 milliliters during a 24 hour period. CCTO:000776 implies CCTO:000049 CCTO:000776 implies CCTO:000051 CCTO:000776(time_t t0) = EVENT_STATE(CCTO:000776, t0) NCI:CTCAE:10059895 NCIT:C80522 UMLS:C0028961 cancer_care_treatment_outcome CCTO:000776 Urine output decreased CCTO:000776 A finding based on test results that indicate urine production is less relative to previous output OR A finding indicating that the urine production is less than 500 milliliters during a 24 hour period. NCI:CTCAE NCIT:C80522 A pulmonary function test result indicating an abnormal vital capacity as compared to the predicted value OR A finding based on pulmonary function test results that indicate an abnormal vital capacity (amount of exhaled after a maximum inhalation) when compared to the predicted value. CCTO:000777 implies CCTO:000049 CCTO:000777 implies CCTO:000051 CCTO:000777(time_t t0) = EVENT_STATE(CCTO:000777, t0) NCI:CTCAE:10047580 NCIT:C78715 UMLS:C0853735 Abnormal vital capacity cancer_care_treatment_outcome CCTO:000777 Vital capacity abnormal CCTO:000777 A pulmonary function test result indicating an abnormal vital capacity as compared to the predicted value OR A finding based on pulmonary function test results that indicate an abnormal vital capacity (amount of exhaled after a maximum inhalation) when compared to the predicted value. NCI:CTCAE NCIT:C78715 Abnormal vital capacity NCIT:C78715 A question about whether an individual is or was bothered by weight gain OR An increase in total body weight OR A finding characterized by an increase in overall body weight; for pediatrics, greater than the baseline growth curve. CCTO:000778 implies CCTO:000049 CCTO:000778 implies CCTO:000051 CCTO:000778(time_t t0) = EVENT_STATE(CCTO:000778, t0) NCI:CTCAE:10047896 NCIT:C125673 NCIT:C55338 NCIT:C62754 UMLS:C0043094 UMLS:C2911647 BWGAIN Body weight gain Bothered by Weight Gain Weight gain adverse event Weight increase cancer_care_treatment_outcome CCTO:000778 Weight gain CCTO:000778 A question about whether an individual is or was bothered by weight gain OR An increase in total body weight OR A finding characterized by an increase in overall body weight; for pediatrics, greater than the baseline growth curve. NCI:CTCAE NCIT:C125673 NCIT:C62754 BWGAIN NCIT:C62754 Body weight gain NCIT:C62754 Bothered by Weight Gain NCIT:C125673 Weight gain adverse event NCIT:C55338 Weight increase NCIT:C62754 A laboratory test result indicating a decreased number of white blood cells in the peripheral blood OR A finding based on laboratory test results that indicate an decrease in number of white blood cells in a blood specimen. CCTO:000779 implies CCTO:000049 CCTO:000779 implies CCTO:000051 CCTO:000779(time_t t0) = EVENT_STATE(CCTO:000779, t0) NCI:CTCAE:10049182 NCIT:C26816 UMLS:C0023530 UMLS:C0750394 Leukocytopenia Leukopenia cancer_care_treatment_outcome CCTO:000779 White blood cell decreased CCTO:000779 A laboratory test result indicating a decreased number of white blood cells in the peripheral blood OR A finding based on laboratory test results that indicate an decrease in number of white blood cells in a blood specimen. NCI:CTCAE NCIT:C26816 Leukocytopenia NCIT:C26816 Leukopenia NCIT:C26816 An abnormally high acidity of the blood and other body tissues. Acidosis can be either respiratory or metabolic OR A disorder characterized by abnormally high acidity (high hydrogen-ion concentration) of the blood and other body tissues OR Increased acidity in the blood secondary to acid base imbalance. Causes include diabetes, kidney failure and shock OR An abnormally high acidity (excess hydrogen-ion concentration) of the blood and other body tissues. CCTO:000780 implies CCTO:000049 CCTO:000780 implies CCTO:001121 CCTO:000780(time_t t0) = EVENT_STATE(CCTO:000780, t0) NCI:CTCAE:10000486 NCIT:C28228 NCIT:C37906 NCIT:C83504 UMLS:C0001122 UMLS:C0220981 Metabolic acidosis cancer_care_treatment_outcome CCTO:000780 Acidosis CCTO:000780 An abnormally high acidity of the blood and other body tissues. Acidosis can be either respiratory or metabolic OR A disorder characterized by abnormally high acidity (high hydrogen-ion concentration) of the blood and other body tissues OR Increased acidity in the blood secondary to acid base imbalance. Causes include diabetes, kidney failure and shock OR An abnormally high acidity (excess hydrogen-ion concentration) of the blood and other body tissues. NCI:CTCAE NCIT:C28228 NCIT:C37906 NCIT:C83504 Metabolic acidosis NCIT:C28228 A disorder characterized by an increase in sensitivity to the adverse effects of alcohol, which can include nasal congestion, skin flushes, heart dysrhythmias, nausea, vomiting, indigestion and headaches OR Increased sensitivity to the adverse effects of alcohol, which can include nasal congestion, skin flushes, heart dysrhythmias, nausea, vomiting, indigestion and headaches. CCTO:000781 implies CCTO:000049 CCTO:000781 implies CCTO:001121 CCTO:000781(time_t t0) = EVENT_STATE(CCTO:000781, t0) NCI:CTCAE:10001598 NCIT:C78167 UMLS:C0151474 cancer_care_treatment_outcome CCTO:000781 Alcohol intolerance CCTO:000781 A disorder characterized by an increase in sensitivity to the adverse effects of alcohol, which can include nasal congestion, skin flushes, heart dysrhythmias, nausea, vomiting, indigestion and headaches OR Increased sensitivity to the adverse effects of alcohol, which can include nasal congestion, skin flushes, heart dysrhythmias, nausea, vomiting, indigestion and headaches. NCI:CTCAE NCIT:C78167 An abnormally high alkalinity (low hydrogen-ion concentration) of the blood and other body tissues OR A disorder characterized by abnormally high alkalinity (low hydrogen-ion concentration) of the blood and other body tissues. CCTO:000782 implies CCTO:000049 CCTO:000782 implies CCTO:001121 CCTO:000782(time_t t0) = EVENT_STATE(CCTO:000782, t0) NCI:CTCAE:10001680 NCIT:C37909 UMLS:C0002063 cancer_care_treatment_outcome CCTO:000782 Alkalosis CCTO:000782 An abnormally high alkalinity (low hydrogen-ion concentration) of the blood and other body tissues OR A disorder characterized by abnormally high alkalinity (low hydrogen-ion concentration) of the blood and other body tissues. NCI:CTCAE NCIT:C37909 Loss of appetite OR A disorder characterized by a loss of appetite. CCTO:000783 implies CCTO:000049 CCTO:000783 implies CCTO:001121 CCTO:000783(time_t t0) = EVENT_STATE(CCTO:000783, t0) NCI:CTCAE:10002646 NCIT:C2875 NCIT:C57118 UMLS:C0003123 UMLS:C1963063 Anorexia adverse event cancer_care_treatment_outcome CCTO:000783 Anorexia CCTO:000783 Loss of appetite OR A disorder characterized by a loss of appetite. NCI:CTCAE NCIT:C2875 Anorexia adverse event NCIT:C57118 A condition resulting from the excessive loss of water from the body. It is usually caused by severe diarrhea, vomiting or diaphoresis OR Any procedure designed to remove the water from a substance or sample OR A disorder characterized by excessive loss of water from the body. It is usually caused by severe diarrhea, vomiting or diaphoresis. CCTO:000784 implies CCTO:000049 CCTO:000784 implies CCTO:001121 CCTO:000784(time_t t0) = EVENT_STATE(CCTO:000784, t0) NCI:CTCAE:10012174 NCIT:C126369 NCIT:C26740 NCIT:C57787 UMLS:C0011175 UMLS:C1963090 Dehydrated Dehydration adverse event Dehydration procedure Dehydration technique cancer_care_treatment_outcome CCTO:000784 Dehydration CCTO:000784 A condition resulting from the excessive loss of water from the body. It is usually caused by severe diarrhea, vomiting or diaphoresis OR Any procedure designed to remove the water from a substance or sample OR A disorder characterized by excessive loss of water from the body. It is usually caused by severe diarrhea, vomiting or diaphoresis. NCI:CTCAE NCIT:C126369 NCIT:C26740 Dehydrated NCIT:C26740 Dehydration adverse event NCIT:C57787 Dehydration procedure NCIT:C126369 Dehydration technique NCIT:C126369 The inability to regulate blood glucose levels resulting in hyperglycemia OR A disorder characterized by an inability to properly metabolize glucose. CCTO:000785 implies CCTO:000049 CCTO:000785 implies CCTO:001121 CCTO:000785(time_t t0) = EVENT_STATE(CCTO:000785, t0) NCI:CTCAE:10052426 NCIT:C34646 UMLS:C0271650 cancer_care_treatment_outcome CCTO:000785 Glucose intolerance CCTO:000785 The inability to regulate blood glucose levels resulting in hyperglycemia OR A disorder characterized by an inability to properly metabolize glucose. NCI:CTCAE NCIT:C34646 Abnormally high concentration of calcium in the peripheral blood OR A disorder characterized by laboratory test results that indicate an elevation in the concentration of calcium (corrected for albumin) in blood. CCTO:000786 implies CCTO:000049 CCTO:000786 implies CCTO:001121 CCTO:000786(time_t t0) = EVENT_STATE(CCTO:000786, t0) NCI:CTCAE:10020587 NCIT:C3112 UMLS:C0020437 cancer_care_treatment_outcome CCTO:000786 Hypercalcemia CCTO:000786 Abnormally high concentration of calcium in the peripheral blood OR A disorder characterized by laboratory test results that indicate an elevation in the concentration of calcium (corrected for albumin) in blood. NCI:CTCAE NCIT:C3112 A disorder characterized by laboratory test results that indicate an elevation in the concentration of blood sugar. It is usually an indication of diabetes mellitus or glucose intolerance OR Abnormally high level of glucose in the blood. CCTO:000787 implies CCTO:000049 CCTO:000787 implies CCTO:001121 CCTO:000787(time_t t0) = EVENT_STATE(CCTO:000787, t0) NCI:CTCAE:10020639 NCIT:C26797 UMLS:C0020456 UMLS:C0595877 Blood glucose, high Elevated blood glucose Glucose, high blood High blood glucose high blood sugar cancer_care_treatment_outcome CCTO:000787 Hyperglycemia CCTO:000787 A disorder characterized by laboratory test results that indicate an elevation in the concentration of blood sugar. It is usually an indication of diabetes mellitus or glucose intolerance OR Abnormally high level of glucose in the blood. NCI:CTCAE NCIT:C26797 Blood glucose, high NCIT:C26797 Elevated blood glucose NCIT:C26797 Glucose, high blood NCIT:C26797 High blood glucose NCIT:C26797 high blood sugar NCIT:C26797 A disorder characterized by laboratory test results that indicate an elevation in the concentration of potassium in the blood; associated with kidney failure or sometimes with the use of diuretic drugs OR Higher than normal levels of potassium in the circulating blood; associated with kidney failure or sometimes with the use of diuretic drugs. CCTO:000788 implies CCTO:000049 CCTO:000788 implies CCTO:001121 CCTO:000788(time_t t0) = EVENT_STATE(CCTO:000788, t0) NCI:CTCAE:10020647 NCIT:C37968 UMLS:C0020461 cancer_care_treatment_outcome CCTO:000788 Hyperkalemia CCTO:000788 A disorder characterized by laboratory test results that indicate an elevation in the concentration of potassium in the blood; associated with kidney failure or sometimes with the use of diuretic drugs OR Higher than normal levels of potassium in the circulating blood; associated with kidney failure or sometimes with the use of diuretic drugs. NCI:CTCAE NCIT:C37968 Higher than normal levels of magnesium in the circulating blood OR A disorder characterized by laboratory test results that indicate an elevation in the concentration of magnesium in the blood. CCTO:000789 implies CCTO:000049 CCTO:000789 implies CCTO:001121 CCTO:000789(time_t t0) = EVENT_STATE(CCTO:000789, t0) NCI:CTCAE:10020670 NCIT:C37969 UMLS:C0151714 cancer_care_treatment_outcome CCTO:000789 Hypermagnesemia CCTO:000789 Higher than normal levels of magnesium in the circulating blood OR A disorder characterized by laboratory test results that indicate an elevation in the concentration of magnesium in the blood. NCI:CTCAE NCIT:C37969 Higher than normal levels of sodium in the circulating blood OR A disorder characterized by laboratory test results that indicate an elevation in the concentration of sodium in the blood. CCTO:000790 implies CCTO:000049 CCTO:000790 implies CCTO:001121 CCTO:000790(time_t t0) = EVENT_STATE(CCTO:000790, t0) NCI:CTCAE:10020680 NCIT:C37970 UMLS:C0020488 cancer_care_treatment_outcome CCTO:000790 Hypernatremia CCTO:000790 Higher than normal levels of sodium in the circulating blood OR A disorder characterized by laboratory test results that indicate an elevation in the concentration of sodium in the blood. NCI:CTCAE NCIT:C37970 A laboratory test result indicating elevated triglyceride concentration in the blood OR A disorder characterized by laboratory test results that indicate an elevation in the concentration of triglyceride concentration in the blood. CCTO:000791 implies CCTO:000049 CCTO:000791 implies CCTO:001121 CCTO:000791(time_t t0) = EVENT_STATE(CCTO:000791, t0) NCI:CTCAE:10020870 NCIT:C37971 UMLS:C0020557 UMLS:C1522137 High triglycerides cancer_care_treatment_outcome CCTO:000791 Hypertriglyceridemia CCTO:000791 A laboratory test result indicating elevated triglyceride concentration in the blood OR A disorder characterized by laboratory test results that indicate an elevation in the concentration of triglyceride concentration in the blood. NCI:CTCAE NCIT:C37971 High triglycerides NCIT:C37971 A disorder characterized by laboratory test results that indicate an elevation in the concentration of uric acid OR Elevated blood concentrations of uric acid. CCTO:000792 implies CCTO:000049 CCTO:000792 implies CCTO:001121 CCTO:000792(time_t t0) = EVENT_STATE(CCTO:000792, t0) NCI:CTCAE:10020907 NCIT:C3961 UMLS:C0740394 cancer_care_treatment_outcome CCTO:000792 Hyperuricemia CCTO:000792 A disorder characterized by laboratory test results that indicate an elevation in the concentration of uric acid OR Elevated blood concentrations of uric acid. NCI:CTCAE NCIT:C3961 A disorder characterized by laboratory test results that indicate a low concentration of albumin in the blood OR Concentration of serum albumin below normal limits for the age related normal range. CCTO:000793 implies CCTO:000049 CCTO:000793 implies CCTO:001121 CCTO:000793(time_t t0) = EVENT_STATE(CCTO:000793, t0) NCI:CTCAE:10020943 NCIT:C37972 UMLS:C0239981 UMLS:C3665623 cancer_care_treatment_outcome CCTO:000793 Hypoalbuminemia CCTO:000793 A disorder characterized by laboratory test results that indicate a low concentration of albumin in the blood OR Concentration of serum albumin below normal limits for the age related normal range. NCI:CTCAE NCIT:C37972 Lower than normal levels of calcium in the circulating blood OR A disorder characterized by laboratory test results that indicate a low concentration of calcium (corrected for albumin) in the blood. CCTO:000794 implies CCTO:000049 CCTO:000794 implies CCTO:001121 CCTO:000794(time_t t0) = EVENT_STATE(CCTO:000794, t0) NCI:CTCAE:10020949 NCIT:C37973 UMLS:C0020598 cancer_care_treatment_outcome CCTO:000794 Hypocalcemia CCTO:000794 Lower than normal levels of calcium in the circulating blood OR A disorder characterized by laboratory test results that indicate a low concentration of calcium (corrected for albumin) in the blood. NCI:CTCAE NCIT:C37973 A disorder characterized by laboratory test results that indicate a low concentration of glucose in the blood OR Abnormally low level of glucose in the blood. CCTO:000795 implies CCTO:000049 CCTO:000795 implies CCTO:001121 CCTO:000795(time_t t0) = EVENT_STATE(CCTO:000795, t0) NCI:CTCAE:10021005 NCIT:C3126 UMLS:C0020615 Blood glucose, low Glucose, low blood Low blood glucose cancer_care_treatment_outcome CCTO:000795 Hypoglycemia CCTO:000795 A disorder characterized by laboratory test results that indicate a low concentration of glucose in the blood OR Abnormally low level of glucose in the blood. NCI:CTCAE NCIT:C3126 Blood glucose, low NCIT:C3126 Glucose, low blood NCIT:C3126 Low blood glucose NCIT:C3126 A disorder characterized by laboratory test results that indicate a low concentration of potassium in the blood OR Lower than normal levels of potassium in the circulating blood. CCTO:000796 implies CCTO:000049 CCTO:000796 implies CCTO:001121 CCTO:000796(time_t t0) = EVENT_STATE(CCTO:000796, t0) NCI:CTCAE:10021018 NCIT:C37974 UMLS:C0020621 cancer_care_treatment_outcome CCTO:000796 Hypokalemia CCTO:000796 A disorder characterized by laboratory test results that indicate a low concentration of potassium in the blood OR Lower than normal levels of potassium in the circulating blood. NCI:CTCAE NCIT:C37974 A disorder characterized by laboratory test results that indicate a low concentration of magnesium in the blood OR Lower than normal levels of magnesium in the circulating blood. CCTO:000797 implies CCTO:000049 CCTO:000797 implies CCTO:001121 CCTO:000797(time_t t0) = EVENT_STATE(CCTO:000797, t0) NCI:CTCAE:10021028 NCIT:C37975 UMLS:C0151723 cancer_care_treatment_outcome CCTO:000797 Hypomagnesemia CCTO:000797 A disorder characterized by laboratory test results that indicate a low concentration of magnesium in the blood OR Lower than normal levels of magnesium in the circulating blood. NCI:CTCAE NCIT:C37975 A disorder characterized by laboratory test results that indicate a low concentration of sodium in the blood OR Lower than normal levels of sodium in the circulating blood. CCTO:000798 implies CCTO:000049 CCTO:000798 implies CCTO:001121 CCTO:000798(time_t t0) = EVENT_STATE(CCTO:000798, t0) NCI:CTCAE:10021038 NCIT:C37976 UMLS:C0020625 cancer_care_treatment_outcome CCTO:000798 Hyponatremia CCTO:000798 A disorder characterized by laboratory test results that indicate a low concentration of sodium in the blood OR Lower than normal levels of sodium in the circulating blood. NCI:CTCAE NCIT:C37976 A disorder characterized by laboratory test results that indicate a low concentration of phosphates in the blood OR Lower than normal levels of phosphates in the circulating blood. CCTO:000799 implies CCTO:000049 CCTO:000799 implies CCTO:001121 CCTO:000799(time_t t0) = EVENT_STATE(CCTO:000799, t0) NCI:CTCAE:10021059 NCIT:C37977 UMLS:C0085682 cancer_care_treatment_outcome CCTO:000799 Hypophosphatemia CCTO:000799 A disorder characterized by laboratory test results that indicate a low concentration of phosphates in the blood OR Lower than normal levels of phosphates in the circulating blood. NCI:CTCAE NCIT:C37977 An adverse event resulting in accumulation of iron in the tissues OR Accumulation of iron in the tissues. It may be a manifestation of an inherited disorder (e.g., hemochromatosis) or acquired (in patients with repeated blood transfusions). Symptoms include hepatomegaly, arthritis, diabetes mellitus, and bronzed skin. If untreated it has a progressive course and may lead to death OR A disorder characterized by accumulation of iron in the tissues. CCTO:000800 implies CCTO:000049 CCTO:000800 implies CCTO:001121 CCTO:000800(time_t t0) = EVENT_STATE(CCTO:000800, t0) NCI:CTCAE:10065973 NCIT:C55993 NCIT:C78393 UMLS:C0282193 UMLS:C1963148 Iron overload adverse event cancer_care_treatment_outcome CCTO:000800 Iron overload CCTO:000800 An adverse event resulting in accumulation of iron in the tissues OR Accumulation of iron in the tissues. It may be a manifestation of an inherited disorder (e.g., hemochromatosis) or acquired (in patients with repeated blood transfusions). Symptoms include hepatomegaly, arthritis, diabetes mellitus, and bronzed skin. If untreated it has a progressive course and may lead to death OR A disorder characterized by accumulation of iron in the tissues. NCI:CTCAE NCIT:C55993 NCIT:C78393 Iron overload adverse event NCIT:C55993 Having a high amount of body fat (body mass index [BMI] of 30 or more) OR A disorder characterized by having a high amount of body fat. CCTO:000801 implies CCTO:000049 CCTO:000801 implies CCTO:001121 CCTO:000801(time_t t0) = EVENT_STATE(CCTO:000801, t0) NCI:CTCAE:10029883 NCIT:C3283 NCIT:C55334 UMLS:C0028754 UMLS:C1963185 Obesity adverse event cancer_care_treatment_outcome CCTO:000801 Obesity CCTO:000801 Having a high amount of body fat (body mass index [BMI] of 30 or more) OR A disorder characterized by having a high amount of body fat. NCI:CTCAE NCIT:C3283 Obesity adverse event NCIT:C55334 A disorder characterized by metabolic abnormalities that result from a spontaneous or therapy-related cytolysis of tumor cells OR A condition of metabolic abnormalities that result from a spontaneous or therapy-related cytolysis of tumor cells. Tumor lysis syndrome typically occurs in aggressive, rapidly proliferating lymphoproliferative disorders. Burkitt lymphoma and T cell acute lymphoblastic leukemia are commonly associated with this syndrome. Metabolic abnormalities include hyperuricemia, lactic acidosis, hyperkalemia, hyperphosphatemia and hypocalcemia and may result in renal failure, multiple organ failure, and death. CCTO:000802 implies CCTO:000049 CCTO:000802 implies CCTO:001121 CCTO:000802(time_t t0) = EVENT_STATE(CCTO:000802, t0) NCI:CTCAE:10045152 NCIT:C3425 NCIT:C56638 UMLS:C0041364 UMLS:C1963254 Tumor lysis syndrome adverse event cancer_care_treatment_outcome CCTO:000802 Tumor lysis syndrome CCTO:000802 A disorder characterized by metabolic abnormalities that result from a spontaneous or therapy-related cytolysis of tumor cells OR A condition of metabolic abnormalities that result from a spontaneous or therapy-related cytolysis of tumor cells. Tumor lysis syndrome typically occurs in aggressive, rapidly proliferating lymphoproliferative disorders. Burkitt lymphoma and T cell acute lymphoblastic leukemia are commonly associated with this syndrome. Metabolic abnormalities include hyperuricemia, lactic acidosis, hyperkalemia, hyperphosphatemia and hypocalcemia and may result in renal failure, multiple organ failure, and death. NCI:CTCAE NCIT:C3425 Tumor lysis syndrome adverse event NCIT:C56638 A necrotic process occurring in the soft tissues of the abdominal wall OR A disorder characterized by a necrotic process occurring in the soft tissues of the abdominal wall. CCTO:000803 implies CCTO:000049 CCTO:000803 implies CCTO:001109 CCTO:000803(time_t t0) = EVENT_STATE(CCTO:000803, t0) NCI:CTCAE:10065775 NCIT:C78165 UMLS:C1699695 Abdominal soft tissue necrotic lesion cancer_care_treatment_outcome CCTO:000803 Abdominal soft tissue necrosis CCTO:000803 A necrotic process occurring in the soft tissues of the abdominal wall OR A disorder characterized by a necrotic process occurring in the soft tissues of the abdominal wall. NCI:CTCAE NCIT:C78165 Abdominal soft tissue necrotic lesion NCIT:C78165 A disorder characterized by a sensation of marked discomfort in a joint OR Pain in a joint. CCTO:000804 implies CCTO:000049 CCTO:000804 implies CCTO:001109 CCTO:000804(time_t t0) = EVENT_STATE(CCTO:000804, t0) NCI:CTCAE:10003239 NCIT:C50464 UMLS:C0003862 UMLS:C1963066 Arthrodynia Joint pain Pain, joint cancer_care_treatment_outcome CCTO:000804 Arthralgia CCTO:000804 A disorder characterized by a sensation of marked discomfort in a joint OR Pain in a joint. NCI:CTCAE NCIT:C50464 Arthrodynia NCIT:C50464 Joint pain NCIT:C50464 Pain, joint NCIT:C50464 A disorder characterized by inflammation involving a joint OR An inflammatory process affecting a joint. Causes include infection, autoimmune processes, degenerative processes, and trauma. Signs and symptoms may include swelling around the affected joint and pain. CCTO:000805 implies CCTO:000049 CCTO:000805 implies CCTO:001109 CCTO:000805(time_t t0) = EVENT_STATE(CCTO:000805, t0) NCI:CTCAE:10003246 NCIT:C2883 UMLS:C0003864 cancer_care_treatment_outcome CCTO:000805 Arthritis CCTO:000805 A disorder characterized by inflammation involving a joint OR An inflammatory process affecting a joint. Causes include infection, autoimmune processes, degenerative processes, and trauma. Signs and symptoms may include swelling around the affected joint and pain. NCI:CTCAE NCIT:C2883 Necrotic changes in the bone tissue due to interruption of blood supply. Most often affecting the epiphysis of the long bones, the necrotic changes result in the collapse and the destruction of the bone structure OR Tissue death resulting from an interruption to the blood supply OR A disorder characterized by necrotic changes in the bone tissue due to interruption of blood supply. Most often affecting the epiphysis of the long bones, the necrotic changes result in the collapse and the destruction of the bone structure. CCTO:000806 implies CCTO:000049 CCTO:000806 implies CCTO:001109 CCTO:000806(time_t t0) = EVENT_STATE(CCTO:000806, t0) NCI:CTCAE:10066480 NCIT:C118385 NCIT:C34841 UMLS:C0027543 AVN Avascular Necrosis of Bone cancer_care_treatment_outcome CCTO:000806 Avascular necrosis CCTO:000806 Necrotic changes in the bone tissue due to interruption of blood supply. Most often affecting the epiphysis of the long bones, the necrotic changes result in the collapse and the destruction of the bone structure OR Tissue death resulting from an interruption to the blood supply OR A disorder characterized by necrotic changes in the bone tissue due to interruption of blood supply. Most often affecting the epiphysis of the long bones, the necrotic changes result in the collapse and the destruction of the bone structure. NCI:CTCAE NCIT:C118385 NCIT:C34841 AVN NCIT:C118385 Avascular Necrosis of Bone NCIT:C34841 A disorder characterized by marked discomfort sensation in the back region OR Painful sensation in the back region. CCTO:000807 implies CCTO:000107 CCTO:000807 implies CCTO:001109 CCTO:000807(time_t t0) = EVENT_STATE(CCTO:000807, t0) NCI:CTCAE:10003988 NCIT:C41830 NCIT:C56010 UMLS:C0004604 UMLS:C1963071 Back pain adverse event cancer_care_treatment_outcome CCTO:000807 Back pain CCTO:000807 A disorder characterized by marked discomfort sensation in the back region OR Painful sensation in the back region. NCI:CTCAE NCIT:C41830 Back pain adverse event NCIT:C56010 A disorder characterized by marked discomfort sensation in the buttocks OR Painful sensation in the buttocks. CCTO:000808 implies CCTO:000107 CCTO:000808 implies CCTO:001109 CCTO:000808(time_t t0) = EVENT_STATE(CCTO:000808, t0) NCI:CTCAE:10048677 NCIT:C56030 NCIT:C78228 UMLS:C0231710 UMLS:C1963189 Buttock pain adverse event cancer_care_treatment_outcome CCTO:000808 Buttock pain CCTO:000808 A disorder characterized by marked discomfort sensation in the buttocks OR Painful sensation in the buttocks. NCI:CTCAE NCIT:C78228 Buttock pain adverse event NCIT:C56030 Painful sensation in the chest wall region OR A disorder characterized by marked discomfort sensation in the chest wall region. CCTO:000809 implies CCTO:000107 CCTO:000809 implies CCTO:001109 CCTO:000809(time_t t0) = EVENT_STATE(CCTO:000809, t0) NCI:CTCAE:10008496 NCIT:C56040 NCIT:C78238 UMLS:C0008035 UMLS:C0476280 UMLS:C1963056 Chest wall pain adverse event Musculoskeletal chest pain cancer_care_treatment_outcome CCTO:000809 Chest wall pain CCTO:000809 Painful sensation in the chest wall region OR A disorder characterized by marked discomfort sensation in the chest wall region. NCI:CTCAE NCIT:C78238 Chest wall pain adverse event NCIT:C56040 Musculoskeletal chest pain NCIT:C78238 Non-neoplastic overgrowth of bone OR A disorder characterized by non-neoplastic overgrowth of bone. CCTO:000810 implies CCTO:000049 CCTO:000810 implies CCTO:001109 CCTO:000810(time_t t0) = EVENT_STATE(CCTO:000810, t0) NCI:CTCAE:10015688 NCIT:C3029 NCIT:C58377 UMLS:C1442903 UMLS:C1956089 UMLS:C1961130 Bone spur Exostosis adverse event cancer_care_treatment_outcome CCTO:000810 Exostosis CCTO:000810 Non-neoplastic overgrowth of bone OR A disorder characterized by non-neoplastic overgrowth of bone. NCI:CTCAE NCIT:C3029 Bone spur NCIT:C3029 Exostosis adverse event NCIT:C58377 A disorder characterized by fibrotic degeneration of the deep connective tissues OR Fibrotic degeneration of the deep connective tissues. CCTO:000811 implies CCTO:000049 CCTO:000811 implies CCTO:001109 CCTO:000811(time_t t0) = EVENT_STATE(CCTO:000811, t0) NCI:CTCAE:10065799 NCIT:C78301 UMLS:C1560030 Deep connective tissue fibrosis cancer_care_treatment_outcome CCTO:000811 Fibrosis deep connective tissue CCTO:000811 A disorder characterized by fibrotic degeneration of the deep connective tissues OR Fibrotic degeneration of the deep connective tissues. NCI:CTCAE NCIT:C78301 Deep connective tissue fibrosis NCIT:C78301 Painful sensation in the region below the ribs and above the hip OR A disorder characterized by marked discomfort sensation on the lateral side of the body in the region below the ribs and above the hip. CCTO:000812 implies CCTO:000107 CCTO:000812 implies CCTO:001109 CCTO:000812(time_t t0) = EVENT_STATE(CCTO:000812, t0) NCI:CTCAE:10016750 NCIT:C34615 UMLS:C0016199 cancer_care_treatment_outcome CCTO:000812 Flank pain CCTO:000812 Painful sensation in the region below the ribs and above the hip OR A disorder characterized by marked discomfort sensation on the lateral side of the body in the region below the ribs and above the hip. NCI:CTCAE NCIT:C34615 A reduction in the strength of muscles in multiple anatomic sites OR A disorder characterized by a reduction in the strength of muscles in multiple anatomic sites. CCTO:000813 implies CCTO:000049 CCTO:000813 implies CCTO:001109 CCTO:000813(time_t t0) = EVENT_STATE(CCTO:000813, t0) NCI:CTCAE:10062572 NCIT:C78323 UMLS:C0746674 cancer_care_treatment_outcome CCTO:000813 Generalized muscle weakness CCTO:000813 A reduction in the strength of muscles in multiple anatomic sites OR A disorder characterized by a reduction in the strength of muscles in multiple anatomic sites. NCI:CTCAE NCIT:C78323 A disorder characterized by of stature that is smaller than normal as expected for age OR Stature that is smaller than normal as expected for age. CCTO:000814 implies CCTO:000049 CCTO:000814 implies CCTO:001109 CCTO:000814(time_t t0) = EVENT_STATE(CCTO:000814, t0) NCI:CTCAE:10018761 NCIT:C78328 UMLS:C0151686 Growth retardation cancer_care_treatment_outcome CCTO:000814 Growth suppression CCTO:000814 A disorder characterized by of stature that is smaller than normal as expected for age OR Stature that is smaller than normal as expected for age. NCI:CTCAE NCIT:C78328 Growth retardation NCIT:C78328 A disorder characterized by a necrotic process occurring in the soft tissues of the head OR A necrotic process affecting the soft tissues of the head. CCTO:000815 implies CCTO:000049 CCTO:000815 implies CCTO:001109 CCTO:000815(time_t t0) = EVENT_STATE(CCTO:000815, t0) NCI:CTCAE:10065779 NCIT:C58383 NCIT:C78331 UMLS:C1561246 UMLS:C1963121 Head soft tissue necrosis adverse event Head soft tissue necrotic lesion cancer_care_treatment_outcome CCTO:000815 Head soft tissue necrosis CCTO:000815 A disorder characterized by a necrotic process occurring in the soft tissues of the head OR A necrotic process affecting the soft tissues of the head. NCI:CTCAE NCIT:C78331 Head soft tissue necrosis adverse event NCIT:C58383 Head soft tissue necrotic lesion NCIT:C78331 Abnormally increased amount of fluid in a joint cavity, usually as a result of joint inflammation OR A disorder characterized by excessive fluid in a joint, usually as a result of joint inflammation. CCTO:000816 implies CCTO:000049 CCTO:000816 implies CCTO:001109 CCTO:000816(time_t t0) = EVENT_STATE(CCTO:000816, t0) NCI:CTCAE:10023215 NCIT:C49052 UMLS:C1253936 cancer_care_treatment_outcome CCTO:000816 Joint effusion CCTO:000816 Abnormally increased amount of fluid in a joint cavity, usually as a result of joint inflammation OR A disorder characterized by excessive fluid in a joint, usually as a result of joint inflammation. NCI:CTCAE NCIT:C49052 A disorder characterized by a decrease in joint flexibility of any joint OR Decreased joint flexibility. CCTO:000817 implies CCTO:000049 CCTO:000817 implies CCTO:001109 CCTO:000817(time_t t0) = EVENT_STATE(CCTO:000817, t0) NCI:CTCAE:10048706 NCIT:C78403 UMLS:C0877027 cancer_care_treatment_outcome CCTO:000817 Joint range of motion decreased CCTO:000817 A disorder characterized by a decrease in joint flexibility of any joint OR Decreased joint flexibility. NCI:CTCAE NCIT:C78403 Decreased flexibility of a cervical spine joint OR A disorder characterized by a decrease in flexibility of a cervical spine joint. CCTO:000818 implies CCTO:000049 CCTO:000818 implies CCTO:001109 CCTO:000818(time_t t0) = EVENT_STATE(CCTO:000818, t0) NCI:CTCAE:10065796 NCIT:C78404 UMLS:C1698040 Cervical Spine Joint Range of Motion Decreased cancer_care_treatment_outcome CCTO:000818 Joint range of motion decreased cervical spine CCTO:000818 Decreased flexibility of a cervical spine joint OR A disorder characterized by a decrease in flexibility of a cervical spine joint. NCI:CTCAE NCIT:C78404 Cervical Spine Joint Range of Motion Decreased NCIT:C78404 Decreased flexibility of a lumbar spine joint OR A disorder characterized by a decrease in flexibility of a lumbar spine joint. CCTO:000819 implies CCTO:000049 CCTO:000819 implies CCTO:001109 CCTO:000819(time_t t0) = EVENT_STATE(CCTO:000819, t0) NCI:CTCAE:10065800 NCIT:C78405 UMLS:C1699182 Lumbar Spine Joint Range of Motion Decreased cancer_care_treatment_outcome CCTO:000819 Joint range of motion decreased lumbar spine CCTO:000819 Decreased flexibility of a lumbar spine joint OR A disorder characterized by a decrease in flexibility of a lumbar spine joint. NCI:CTCAE NCIT:C78405 Lumbar Spine Joint Range of Motion Decreased NCIT:C78405 Abnormally increased curvature of the thoracic portion of the spine OR A disorder characterized by an abnormal increase in the curvature of the thoracic portion of the spine. CCTO:000820 implies CCTO:000049 CCTO:000820 implies CCTO:001109 CCTO:000820(time_t t0) = EVENT_STATE(CCTO:000820, t0) NCI:CTCAE:10023509 NCIT:C34754 UMLS:C0022821 cancer_care_treatment_outcome CCTO:000820 Kyphosis CCTO:000820 Abnormally increased curvature of the thoracic portion of the spine OR A disorder characterized by an abnormal increase in the curvature of the thoracic portion of the spine. NCI:CTCAE NCIT:C34754 Abnormally increased curvature of the lumbar portion of the spinal column OR A disorder characterized by an abnormal increase in the curvature of the lumbar portion of the spine. CCTO:000821 implies CCTO:000049 CCTO:000821 implies CCTO:001109 CCTO:000821(time_t t0) = EVENT_STATE(CCTO:000821, t0) NCI:CTCAE:10024842 NCIT:C34787 UMLS:C0024003 cancer_care_treatment_outcome CCTO:000821 Lordosis CCTO:000821 Abnormally increased curvature of the lumbar portion of the spinal column OR A disorder characterized by an abnormal increase in the curvature of the lumbar portion of the spine. NCI:CTCAE NCIT:C34787 A disorder characterized by a reduction in the strength of the muscles on the left side of the body OR A reduction in the strength of the muscles in the left side of the body. CCTO:000822 implies CCTO:000049 CCTO:000822 implies CCTO:001109 CCTO:000822(time_t t0) = EVENT_STATE(CCTO:000822, t0) NCI:CTCAE:10065780 NCIT:C78455 UMLS:C1698038 cancer_care_treatment_outcome CCTO:000822 Muscle weakness left-sided CCTO:000822 A disorder characterized by a reduction in the strength of the muscles on the left side of the body OR A reduction in the strength of the muscles in the left side of the body. NCI:CTCAE NCIT:C78455 A reduction in the strength of the lower limb muscles OR A disorder characterized by a reduction in the strength of the lower limb muscles. CCTO:000823 implies CCTO:000049 CCTO:000823 implies CCTO:001109 CCTO:000823(time_t t0) = EVENT_STATE(CCTO:000823, t0) NCI:CTCAE:10065776 NCIT:C78456 UMLS:C1698037 cancer_care_treatment_outcome CCTO:000823 Muscle weakness lower limb CCTO:000823 A reduction in the strength of the lower limb muscles OR A disorder characterized by a reduction in the strength of the lower limb muscles. NCI:CTCAE NCIT:C78456 A reduction in the strength of the muscles in the right side of the body OR A disorder characterized by a reduction in the strength of the muscles on the right side of the body. CCTO:000824 implies CCTO:000049 CCTO:000824 implies CCTO:001109 CCTO:000824(time_t t0) = EVENT_STATE(CCTO:000824, t0) NCI:CTCAE:10065794 NCIT:C78457 UMLS:C1699181 cancer_care_treatment_outcome CCTO:000824 Muscle weakness right-sided CCTO:000824 A reduction in the strength of the muscles in the right side of the body OR A disorder characterized by a reduction in the strength of the muscles on the right side of the body. NCI:CTCAE NCIT:C78457 A disorder characterized by a reduction in the strength of the trunk muscles OR A reduction in the strength of the trunk muscles. CCTO:000825 implies CCTO:000049 CCTO:000825 implies CCTO:001109 CCTO:000825(time_t t0) = EVENT_STATE(CCTO:000825, t0) NCI:CTCAE:10065795 NCIT:C78458 UMLS:C0241492 cancer_care_treatment_outcome CCTO:000825 Muscle weakness trunk CCTO:000825 A disorder characterized by a reduction in the strength of the trunk muscles OR A reduction in the strength of the trunk muscles. NCI:CTCAE NCIT:C78458 A disorder characterized by a reduction in the strength of the upper limb muscles OR A reduction in the strength of the upper limb muscles. CCTO:000826 implies CCTO:000049 CCTO:000826 implies CCTO:001109 CCTO:000826(time_t t0) = EVENT_STATE(CCTO:000826, t0) NCI:CTCAE:10065895 NCIT:C78459 UMLS:C1698196 cancer_care_treatment_outcome CCTO:000826 Muscle weakness upper limb CCTO:000826 A disorder characterized by a reduction in the strength of the upper limb muscles OR A reduction in the strength of the upper limb muscles. NCI:CTCAE NCIT:C78459 A disorder characterized by of a malformation of the musculoskeletal system OR Congenital or acquired deformity of the musculoskeletal system. CCTO:000827 implies CCTO:000049 CCTO:000827 implies CCTO:001109 CCTO:000827(time_t t0) = EVENT_STATE(CCTO:000827, t0) NCI:CTCAE:10065783 NCIT:C78488 UMLS:C0281914 cancer_care_treatment_outcome CCTO:000827 Musculoskeletal deformity CCTO:000827 A disorder characterized by of a malformation of the musculoskeletal system OR Congenital or acquired deformity of the musculoskeletal system. NCI:CTCAE NCIT:C78488 A disorder characterized by marked discomfort sensation originating from a muscle or group of muscles OR Painful sensation originating from a muscle or group of muscles. CCTO:000828 implies CCTO:000049 CCTO:000828 implies CCTO:001109 CCTO:000828(time_t t0) = EVENT_STATE(CCTO:000828, t0) NCI:CTCAE:10028411 NCIT:C27009 UMLS:C0231528 Muscle pain cancer_care_treatment_outcome CCTO:000828 Myalgia CCTO:000828 A disorder characterized by marked discomfort sensation originating from a muscle or group of muscles OR Painful sensation originating from a muscle or group of muscles. NCI:CTCAE NCIT:C27009 Muscle pain NCIT:C27009 An inflammatory process affecting the skeletal muscles. Causes include infections, injuries, and autoimmune disorders OR A disorder characterized by inflammation involving the skeletal muscles. CCTO:000829 implies CCTO:000049 CCTO:000829 implies CCTO:001109 CCTO:000829(time_t t0) = EVENT_STATE(CCTO:000829, t0) NCI:CTCAE:10028653 NCIT:C27578 UMLS:C0027121 cancer_care_treatment_outcome CCTO:000829 Myositis CCTO:000829 An inflammatory process affecting the skeletal muscles. Causes include infections, injuries, and autoimmune disorders OR A disorder characterized by inflammation involving the skeletal muscles. NCI:CTCAE NCIT:C27578 Painful sensation in the neck area OR A disorder characterized by marked discomfort sensation in the neck area. CCTO:000830 implies CCTO:000107 CCTO:000830 implies CCTO:001109 CCTO:000830(time_t t0) = EVENT_STATE(CCTO:000830, t0) NCI:CTCAE:10028836 NCIT:C50663 NCIT:C56135 UMLS:C0007859 UMLS:C1963180 Neck pain adverse event Pain in neck Pain, neck cancer_care_treatment_outcome CCTO:000830 Neck pain CCTO:000830 Painful sensation in the neck area OR A disorder characterized by marked discomfort sensation in the neck area. NCI:CTCAE NCIT:C50663 Neck pain adverse event NCIT:C56135 Pain in neck NCIT:C50663 Pain, neck NCIT:C50663 A necrotic process affecting the soft tissues of the neck OR A disorder characterized by a necrotic process occurring in the soft tissues of the neck. CCTO:000831 implies CCTO:000049 CCTO:000831 implies CCTO:001109 CCTO:000831(time_t t0) = EVENT_STATE(CCTO:000831, t0) NCI:CTCAE:10065781 NCIT:C58394 NCIT:C78502 UMLS:C1561251 UMLS:C1963181 Neck soft tissue necrosis adverse event Neck soft tissue necrotic lesion cancer_care_treatment_outcome CCTO:000831 Neck soft tissue necrosis CCTO:000831 A necrotic process affecting the soft tissues of the neck OR A disorder characterized by a necrotic process occurring in the soft tissues of the neck. NCI:CTCAE NCIT:C78502 Neck soft tissue necrosis adverse event NCIT:C58394 Neck soft tissue necrotic lesion NCIT:C78502 A disorder characterized by a necrotic process occurring in the bone of the mandible OR An area of necrotic bone in the mandible or maxilla. CCTO:000832 implies CCTO:000049 CCTO:000832 implies CCTO:001109 CCTO:000832(time_t t0) = EVENT_STATE(CCTO:000832, t0) NCI:CTCAE:10064658 NCIT:C63924 UMLS:C2711248 Jaw osteonecrosis ONJ cancer_care_treatment_outcome CCTO:000832 Osteonecrosis of jaw CCTO:000832 A disorder characterized by a necrotic process occurring in the bone of the mandible OR An area of necrotic bone in the mandible or maxilla. NCI:CTCAE NCIT:C63924 Jaw osteonecrosis NCIT:C63924 ONJ NCIT:C63924 A condition of reduced bone mass, with decreased cortical thickness and a decrease in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. Osteoporosis is classified as primary (Type 1, postmenopausal osteoporosis; Type 2, age-associated osteoporosis; and idiopathic, which can affect juveniles, premenopausal women, and middle-aged men) and secondary osteoporosis (which results from an identifiable cause of bone mass loss) OR A disorder characterized by reduced bone mass, with a decrease in cortical thickness and in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. CCTO:000833 implies CCTO:000049 CCTO:000833 implies CCTO:001109 CCTO:000833(time_t t0) = EVENT_STATE(CCTO:000833, t0) NCI:CTCAE:10031282 NCIT:C3298 NCIT:C58396 UMLS:C0029456 UMLS:C1962963 Osteoporosis adverse event cancer_care_treatment_outcome CCTO:000833 Osteoporosis CCTO:000833 A condition of reduced bone mass, with decreased cortical thickness and a decrease in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. Osteoporosis is classified as primary (Type 1, postmenopausal osteoporosis; Type 2, age-associated osteoporosis; and idiopathic, which can affect juveniles, premenopausal women, and middle-aged men) and secondary osteoporosis (which results from an identifiable cause of bone mass loss) OR A disorder characterized by reduced bone mass, with a decrease in cortical thickness and in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. NCI:CTCAE NCIT:C3298 Osteoporosis adverse event NCIT:C58396 Painful sensation in the upper or lower extremities OR A disorder characterized by marked discomfort sensation in the upper or lower extremities. CCTO:000834 implies CCTO:000049 CCTO:000834 implies CCTO:001109 CCTO:000834(time_t t0) = EVENT_STATE(CCTO:000834, t0) NCI:CTCAE:10033425 NCIT:C78515 UMLS:C0030196 cancer_care_treatment_outcome CCTO:000834 Pain in extremity CCTO:000834 Painful sensation in the upper or lower extremities OR A disorder characterized by marked discomfort sensation in the upper or lower extremities. NCI:CTCAE NCIT:C78515 A necrotic process affecting the soft tissues of the pelvis OR A disorder characterized by a necrotic process occurring in the soft tissues of the pelvis. CCTO:000835 implies CCTO:000049 CCTO:000835 implies CCTO:001109 CCTO:000835(time_t t0) = EVENT_STATE(CCTO:000835, t0) NCI:CTCAE:10065793 NCIT:C58399 NCIT:C78525 UMLS:C1561256 UMLS:C1962964 Pelvic soft tissue necrosis adverse event Pelvic soft tissue necrotic lesion cancer_care_treatment_outcome CCTO:000835 Pelvic soft tissue necrosis CCTO:000835 A necrotic process affecting the soft tissues of the pelvis OR A disorder characterized by a necrotic process occurring in the soft tissues of the pelvis. NCI:CTCAE NCIT:C78525 Pelvic soft tissue necrosis adverse event NCIT:C58399 Pelvic soft tissue necrotic lesion NCIT:C78525 A disorder characterized by a malformed, lateral curvature of the spine OR A congenital or acquired spinal deformity characterized by lateral curvature of the spine. CCTO:000836 implies CCTO:000049 CCTO:000836 implies CCTO:001109 CCTO:000836(time_t t0) = EVENT_STATE(CCTO:000836, t0) NCI:CTCAE:10039722 NCIT:C78603 UMLS:C0036439 cancer_care_treatment_outcome CCTO:000836 Scoliosis CCTO:000836 A disorder characterized by a malformed, lateral curvature of the spine OR A congenital or acquired spinal deformity characterized by lateral curvature of the spine. NCI:CTCAE NCIT:C78603 A disorder characterized by a necrotic process occurring in the soft tissues of the lower extremity OR A necrotic process affecting the soft tissues of the lower extremity. CCTO:000837 implies CCTO:000049 CCTO:000837 implies CCTO:001109 CCTO:000837(time_t t0) = EVENT_STATE(CCTO:000837, t0) NCI:CTCAE:10065777 NCIT:C78620 UMLS:C1698668 Lower limb soft tissue necrotic lesion cancer_care_treatment_outcome CCTO:000837 Soft tissue necrosis lower limb CCTO:000837 A disorder characterized by a necrotic process occurring in the soft tissues of the lower extremity OR A necrotic process affecting the soft tissues of the lower extremity. NCI:CTCAE NCIT:C78620 Lower limb soft tissue necrotic lesion NCIT:C78620 A disorder characterized by a necrotic process occurring in the soft tissues of the upper extremity OR A necrotic process affecting the soft tissues of the upper extremity. CCTO:000838 implies CCTO:000049 CCTO:000838 implies CCTO:001109 CCTO:000838(time_t t0) = EVENT_STATE(CCTO:000838, t0) NCI:CTCAE:10065778 NCIT:C78621 UMLS:C1698634 Upper limb soft tissue necrotic lesion cancer_care_treatment_outcome CCTO:000838 Soft tissue necrosis upper limb CCTO:000838 A disorder characterized by a necrotic process occurring in the soft tissues of the upper extremity OR A necrotic process affecting the soft tissues of the upper extremity. NCI:CTCAE NCIT:C78621 Upper limb soft tissue necrotic lesion NCIT:C78621 Fibrotic degeneration of the superficial soft tissues OR A disorder characterized by fibrotic degeneration of the superficial soft tissues. CCTO:000839 implies CCTO:000049 CCTO:000839 implies CCTO:001109 CCTO:000839(time_t t0) = EVENT_STATE(CCTO:000839, t0) NCI:CTCAE:10065798 NCIT:C78633 UMLS:C1698669 cancer_care_treatment_outcome CCTO:000839 Superficial soft tissue fibrosis CCTO:000839 Fibrotic degeneration of the superficial soft tissues OR A disorder characterized by fibrotic degeneration of the superficial soft tissues. NCI:CTCAE NCIT:C78633 A disorder characterized by lack of ability to open the mouth fully due to a decrease in the range of motion of the muscles of mastication OR Lack of ability to open the mouth fully due to decreased range of motion of the muscles of mastication. It may be a symptom of tetanus. CCTO:000840 implies CCTO:000049 CCTO:000840 implies CCTO:001109 CCTO:000840(time_t t0) = EVENT_STATE(CCTO:000840, t0) NCI:CTCAE:10044684 NCIT:C78651 UMLS:C0041105 cancer_care_treatment_outcome CCTO:000840 Trismus CCTO:000840 A disorder characterized by lack of ability to open the mouth fully due to a decrease in the range of motion of the muscles of mastication OR Lack of ability to open the mouth fully due to decreased range of motion of the muscles of mastication. It may be a symptom of tetanus. NCI:CTCAE NCIT:C78651 A disorder characterized by of a discrepancy between the lengths of the lower or upper extremities OR Discrepancy between the lengths of the lower or upper extremities. CCTO:000841 implies CCTO:000049 CCTO:000841 implies CCTO:001109 CCTO:000841(time_t t0) = EVENT_STATE(CCTO:000841, t0) NCI:CTCAE:10065738 NCIT:C78657 UMLS:C0494930 cancer_care_treatment_outcome CCTO:000841 Unequal limb length CCTO:000841 A disorder characterized by of a discrepancy between the lengths of the lower or upper extremities OR Discrepancy between the lengths of the lower or upper extremities. NCI:CTCAE NCIT:C78657 A leukemia arising as a result of the mutagenic effect of chemotherapy agents that are used for the treatment of a malignant tumor OR A disorder characterized by leukemia arising as a result of the mutagenic effect of chemotherapy agents. CCTO:000842 implies CCTO:000049 CCTO:000842 implies CCTO:001122 CCTO:000842(time_t t0) = EVENT_STATE(CCTO:000842, t0) NCI:CTCAE:10048293 NCIT:C80691 UMLS:C0863127 Chemotherapy-related leukemia cancer_care_treatment_outcome CCTO:000842 Leukemia secondary to oncology chemotherapy CCTO:000842 A leukemia arising as a result of the mutagenic effect of chemotherapy agents that are used for the treatment of a malignant tumor OR A disorder characterized by leukemia arising as a result of the mutagenic effect of chemotherapy agents. NCI:CTCAE NCIT:C80691 Chemotherapy-related leukemia NCIT:C80691 Myelodysplastic Syndrome is an NCI Cancer Therapeutic Evaluation Program (CTEP) Simplified Disease Classification (SDC) category used to organize cancer-related disease coding that harmonizes with and supports reporting based on the global standard Medical Dictionary for Drug Regulatory Reporting (MedDRA) terminology OR A clonal hematopoietic disorder characterized by dysplasia and ineffective hematopoiesis in one or more of the hematopoietic cell lines. The dysplasia may be accompanied by an increase in myeloblasts, but the number is less than 20%, which, according to the WHO guidelines, is the requisite threshold for the diagnosis of acute myeloid leukemia. It may occur de novo or as a result of exposure to alkylating agents and/or radiotherapy. (WHO, 2001) OR A disorder characterized by insufficiently healthy hematapoietic cell production by the bone marrow. CCTO:000843 implies CCTO:000049 CCTO:000843 implies CCTO:001122 CCTO:000843(time_t t0) = EVENT_STATE(CCTO:000843, t0) NCI:CTCAE:10028533 NCIT:C103128 NCIT:C3247 UMLS:C0002894 UMLS:C0026985 UMLS:C0026986 UMLS:C0033027 UMLS:C2698684 UMLS:C3463824 UMLS:C3538995 Dysmyelopoietic syndrome Hematopoeitic - Myelodysplastic Syndrome (MDS) MDS Myelodysplasia Myelodysplastic neoplasm Myelodysplastic syndrome, NOS Myelodysplastic syndrome/neoplasm NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology NCI CTEP Simple Disease Classification Myelodysplastic Syndrome Sub-Category Terminology Oligoblastic leukemia Preleukemia Smoldering leukemia myelodysplastic syndromes cancer_care_treatment_outcome CCTO:000843 Myelodysplastic syndrome CCTO:000843 Myelodysplastic Syndrome is an NCI Cancer Therapeutic Evaluation Program (CTEP) Simplified Disease Classification (SDC) category used to organize cancer-related disease coding that harmonizes with and supports reporting based on the global standard Medical Dictionary for Drug Regulatory Reporting (MedDRA) terminology OR A clonal hematopoietic disorder characterized by dysplasia and ineffective hematopoiesis in one or more of the hematopoietic cell lines. The dysplasia may be accompanied by an increase in myeloblasts, but the number is less than 20%, which, according to the WHO guidelines, is the requisite threshold for the diagnosis of acute myeloid leukemia. It may occur de novo or as a result of exposure to alkylating agents and/or radiotherapy. (WHO, 2001) OR A disorder characterized by insufficiently healthy hematapoietic cell production by the bone marrow. NCI:CTCAE NCIT:C103128 NCIT:C3247 Dysmyelopoietic syndrome NCIT:C3247 Hematopoeitic - Myelodysplastic Syndrome (MDS) NCIT:C3247 MDS NCIT:C3247 Myelodysplasia NCIT:C3247 Myelodysplastic neoplasm NCIT:C3247 Myelodysplastic syndrome, NOS NCIT:C3247 Myelodysplastic syndrome/neoplasm NCIT:C3247 NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology NCIT:C103128 NCI CTEP Simple Disease Classification Myelodysplastic Syndrome Sub-Category Terminology NCIT:C103128 Oligoblastic leukemia NCIT:C3247 Preleukemia NCIT:C3247 Smoldering leukemia NCIT:C3247 myelodysplastic syndromes NCIT:C3247 The development of a malignant neoplasm in response to medical or surgical treatment, induced by the treatment itself OR A disorder characterized by development of a malignancy most probably as a result of treatment for a previously existing malignancy. CCTO:000844 implies CCTO:000049 CCTO:000844 implies CCTO:001122 CCTO:000844(time_t t0) = EVENT_STATE(CCTO:000844, t0) NCI:CTCAE:10049737 NCIT:C4969 UMLS:C0877578 Iatrogenic cancer Therapy related cancer Therapy related malignant neoplasm Therapy related malignant tumor Therapy-related malignant neoplasm cancer_care_treatment_outcome CCTO:000844 Treatment related secondary malignancy CCTO:000844 The development of a malignant neoplasm in response to medical or surgical treatment, induced by the treatment itself OR A disorder characterized by development of a malignancy most probably as a result of treatment for a previously existing malignancy. NCI:CTCAE NCIT:C4969 Iatrogenic cancer NCIT:C4969 Therapy related cancer NCIT:C4969 Therapy related malignant neoplasm NCIT:C4969 Therapy related malignant tumor NCIT:C4969 Therapy-related malignant neoplasm NCIT:C4969 A painful sensation caused by the tumor growth OR A disorder characterized by marked discomfort from a neoplasm that may be pressing on a nerve, blocking blood vessels, inflamed or fractured from metastasis. CCTO:000845 implies CCTO:000107 CCTO:000845 implies CCTO:001122 CCTO:000845(time_t t0) = EVENT_STATE(CCTO:000845, t0) NCI:CTCAE:10045158 NCIT:C56245 NCIT:C78656 UMLS:C0854069 UMLS:C1963255 Tumor pain adverse event cancer_care_treatment_outcome CCTO:000845 Tumor pain CCTO:000845 A painful sensation caused by the tumor growth OR A disorder characterized by marked discomfort from a neoplasm that may be pressing on a nerve, blocking blood vessels, inflamed or fractured from metastasis. NCI:CTCAE NCIT:C78656 Tumor pain adverse event NCIT:C56245 A non-neoplastic or neoplastic disorder affecting the abducens nerve (sixth cranial nerve) OR A disorder characterized by involvement of the abducens nerve (sixth cranial nerve). CCTO:000846 implies CCTO:000049 CCTO:000846 implies CCTO:001123 CCTO:000846(time_t t0) = EVENT_STATE(CCTO:000846, t0) NCI:CTCAE:10053662 NCIT:C27593 UMLS:C0271355 Abducens nerve disease VIth Nerve Disorder cancer_care_treatment_outcome CCTO:000846 Abducens nerve disorder CCTO:000846 A non-neoplastic or neoplastic disorder affecting the abducens nerve (sixth cranial nerve) OR A disorder characterized by involvement of the abducens nerve (sixth cranial nerve). NCI:CTCAE NCIT:C27593 Abducens nerve disease NCIT:C27593 VIth Nerve Disorder NCIT:C27593 A non-neoplastic or neoplastic disorder affecting the accessory nerve (eleventh cranial nerve) OR A disorder characterized by involvement of the accessory nerve (eleventh cranial nerve). CCTO:000847 implies CCTO:000049 CCTO:000847 implies CCTO:001123 CCTO:000847(time_t t0) = EVENT_STATE(CCTO:000847, t0) NCI:CTCAE:10060929 NCIT:C26953 UMLS:C0152180 Disorder of 11th Nerve Disorder of the 11th Nerve Eleventh nerve disorder cancer_care_treatment_outcome CCTO:000847 Accessory nerve disorder CCTO:000847 A non-neoplastic or neoplastic disorder affecting the accessory nerve (eleventh cranial nerve) OR A disorder characterized by involvement of the accessory nerve (eleventh cranial nerve). NCI:CTCAE NCIT:C26953 Disorder of 11th Nerve NCIT:C26953 Disorder of the 11th Nerve NCIT:C26953 Eleventh nerve disorder NCIT:C26953 A disorder characterized by involvement of the acoustic nerve (eighth cranial nerve) OR A non-neoplastic or neoplastic disorder affecting the acoustic nerve. CCTO:000848 implies CCTO:000049 CCTO:000848 implies CCTO:001123 CCTO:000848(time_t t0) = EVENT_STATE(CCTO:000848, t0) NCI:CTCAE:10000521 NCIT:C27207 UMLS:C0001163 UMLS:C0750885 Acoustic nerve disorder Vestibulocochlear nerve disorder cancer_care_treatment_outcome CCTO:000848 Acoustic nerve disorder NOS CCTO:000848 A disorder characterized by involvement of the acoustic nerve (eighth cranial nerve) OR A non-neoplastic or neoplastic disorder affecting the acoustic nerve. NCI:CTCAE NCIT:C27207 Acoustic nerve disorder NCIT:C27207 Vestibulocochlear nerve disorder NCIT:C27207 An uncomfortable feeling of inner restlessness and inability to stay still. It can be a side effect of psychotropic medications OR A disorder characterized by an uncomfortable feeling of inner restlessness and inability to stay still; this is a side effect of some psychotropic drugs. CCTO:000849 implies CCTO:000049 CCTO:000849 implies CCTO:001123 CCTO:000849(time_t t0) = EVENT_STATE(CCTO:000849, t0) NCI:CTCAE:10001540 NCIT:C78163 UMLS:C0392156 cancer_care_treatment_outcome CCTO:000849 Akathisia CCTO:000849 An uncomfortable feeling of inner restlessness and inability to stay still. It can be a side effect of psychotropic medications OR A disorder characterized by an uncomfortable feeling of inner restlessness and inability to stay still; this is a side effect of some psychotropic drugs. NCI:CTCAE NCIT:C78163 A disorder characterized by systematic and extensive loss of memory OR Systematic and extensive loss of memory caused by organic or psychological factors. The loss may be temporary or permanent, and may involve old or recent memories. CCTO:000850 implies CCTO:000049 CCTO:000850 implies CCTO:001123 CCTO:000850(time_t t0) = EVENT_STATE(CCTO:000850, t0) NCI:CTCAE:10001949 NCIT:C2867 UMLS:C0002622 UMLS:C0751295 Loss of memory Memory loss cancer_care_treatment_outcome CCTO:000850 Amnesia CCTO:000850 A disorder characterized by systematic and extensive loss of memory OR Systematic and extensive loss of memory caused by organic or psychological factors. The loss may be temporary or permanent, and may involve old or recent memories. NCI:CTCAE NCIT:C2867 Loss of memory NCIT:C2867 Memory loss NCIT:C2867 A disorder characterized by the inability to speak. It may result from injuries to the vocal cords or may be functional (psychogenic) OR A term referring to the inability to speak. It may result from injuries to the vocal cords or may be functional (psychogenic). CCTO:000851 implies CCTO:000049 CCTO:000851 implies CCTO:001123 CCTO:000851(time_t t0) = EVENT_STATE(CCTO:000851, t0) NCI:CTCAE:10002953 NCIT:C79539 UMLS:C0003564 cancer_care_treatment_outcome CCTO:000851 Aphonia CCTO:000851 A disorder characterized by the inability to speak. It may result from injuries to the vocal cords or may be functional (psychogenic) OR A term referring to the inability to speak. It may result from injuries to the vocal cords or may be functional (psychogenic). NCI:CTCAE NCIT:C79539 A disorder characterized by inflammation of the arachnoid membrane and adjacent subarachnoid space OR Inflammation of the arachnoid membrane and adjacent subarachnoid space. CCTO:000852 implies CCTO:000049 CCTO:000852 implies CCTO:001123 CCTO:000852(time_t t0) = EVENT_STATE(CCTO:000852, t0) NCI:CTCAE:10003074 NCIT:C37913 UMLS:C0003708 cancer_care_treatment_outcome CCTO:000852 Arachnoiditis CCTO:000852 A disorder characterized by inflammation of the arachnoid membrane and adjacent subarachnoid space OR Inflammation of the arachnoid membrane and adjacent subarachnoid space. NCI:CTCAE NCIT:C37913 Lack of coordination of muscle movements resulting in the impairment or inability to perform voluntary activities. Causes include peripheral nerve disorders, posterior column injuries, cerebral and cerebellar disorders, basal ganglia disorders, and thalamic disorders OR A disorder characterized by lack of coordination of muscle movements resulting in the impairment or inability to perform voluntary activities. CCTO:000853 implies CCTO:000049 CCTO:000853 implies CCTO:001123 CCTO:000853(time_t t0) = EVENT_STATE(CCTO:000853, t0) NCI:CTCAE:10003591 NCIT:C26702 UMLS:C0004134 cancer_care_treatment_outcome CCTO:000853 Ataxia CCTO:000853 Lack of coordination of muscle movements resulting in the impairment or inability to perform voluntary activities. Causes include peripheral nerve disorders, posterior column injuries, cerebral and cerebellar disorders, basal ganglia disorders, and thalamic disorders OR A disorder characterized by lack of coordination of muscle movements resulting in the impairment or inability to perform voluntary activities. NCI:CTCAE NCIT:C26702 A disorder characterized by regional paresthesia of the brachial plexus, marked discomfort and muscle weakness, and limited movement in the arm or hand OR A brachial plexus disorder characterized by regional paresthesia, pain and muscle weakness, and limited movement in the arm or hand. CCTO:000854 implies CCTO:000049 CCTO:000854 implies CCTO:001123 CCTO:000854(time_t t0) = EVENT_STATE(CCTO:000854, t0) NCI:CTCAE:10065417 NCIT:C27194 NCIT:C55356 UMLS:C0700251 UMLS:C1963078 Brachial plexopathy adverse event Brachial plexus neuropathy cancer_care_treatment_outcome CCTO:000854 Brachial plexopathy CCTO:000854 A disorder characterized by regional paresthesia of the brachial plexus, marked discomfort and muscle weakness, and limited movement in the arm or hand OR A brachial plexus disorder characterized by regional paresthesia, pain and muscle weakness, and limited movement in the arm or hand. NCI:CTCAE NCIT:C27194 Brachial plexopathy adverse event NCIT:C55356 Brachial plexus neuropathy NCIT:C27194 A disorder characterized by a necrotic process occurring in the brain and/or spinal cord OR A necrotic process affecting the brain and/or spinal cord. CCTO:000855 implies CCTO:000049 CCTO:000855 implies CCTO:001123 CCTO:000855(time_t t0) = EVENT_STATE(CCTO:000855, t0) NCI:CTCAE:10065784 NCIT:C78236 UMLS:C1392207 Central nervous system necrotic lesion cancer_care_treatment_outcome CCTO:000855 Central nervous system necrosis CCTO:000855 A disorder characterized by a necrotic process occurring in the brain and/or spinal cord OR A necrotic process affecting the brain and/or spinal cord. NCI:CTCAE NCIT:C78236 Central nervous system necrotic lesion NCIT:C78236 A disorder characterized by loss of cerebrospinal fluid into the surrounding tissues OR The loss of cerebrospinal fluid into the surrounding tissues. CCTO:000856 implies CCTO:000049 CCTO:000856 implies CCTO:001123 CCTO:000856(time_t t0) = EVENT_STATE(CCTO:000856, t0) NCI:CTCAE:10008164 NCIT:C50487 UMLS:C0023182 UMLS:C2936821 Fluid, leakage of cerebrospinal Leakage of cerebrospinal fluid cancer_care_treatment_outcome CCTO:000856 Cerebrospinal fluid leakage CCTO:000856 A disorder characterized by loss of cerebrospinal fluid into the surrounding tissues OR The loss of cerebrospinal fluid into the surrounding tissues. NCI:CTCAE NCIT:C50487 Fluid, leakage of cerebrospinal NCIT:C50487 Leakage of cerebrospinal fluid NCIT:C50487 A notable change in cognitive function OR A disorder characterized by a conspicuous change in cognitive function. CCTO:000857 implies CCTO:000049 CCTO:000857 implies CCTO:001123 CCTO:000857(time_t t0) = EVENT_STATE(CCTO:000857, t0) NCI:CTCAE:10009845 NCIT:C27101 NCIT:C55373 UMLS:C0338656 UMLS:C1963144 Cognitive disturbance adverse event Neurocognitive disturbance cancer_care_treatment_outcome CCTO:000857 Cognitive disturbance CCTO:000857 A notable change in cognitive function OR A disorder characterized by a conspicuous change in cognitive function. NCI:CTCAE NCIT:C27101 Cognitive disturbance adverse event NCIT:C55373 Neurocognitive disturbance NCIT:C27101 A disorder characterized by a deterioration in the ability to concentrate OR Deterioration in the ability to concentrate. CCTO:000858 implies CCTO:000049 CCTO:000858 implies CCTO:001123 CCTO:000858(time_t t0) = EVENT_STATE(CCTO:000858, t0) NCI:CTCAE:10010250 NCIT:C80081 UMLS:C0235198 cancer_care_treatment_outcome CCTO:000858 Concentration impairment CCTO:000858 A disorder characterized by a deterioration in the ability to concentrate OR Deterioration in the ability to concentrate. NCI:CTCAE NCIT:C80081 A neurologic state characterized by decreased ability to perceive and respond OR A disorder characterized by a decrease in ability to perceive and respond. CCTO:000859 implies CCTO:000049 CCTO:000859 implies CCTO:001123 CCTO:000859(time_t t0) = EVENT_STATE(CCTO:000859, t0) NCI:CTCAE:10012373 NCIT:C78253 UMLS:C0344315 UMLS:C0549249 DEPRESSED cancer_care_treatment_outcome CCTO:000859 Depressed level of consciousness CCTO:000859 A neurologic state characterized by decreased ability to perceive and respond OR A disorder characterized by a decrease in ability to perceive and respond. NCI:CTCAE NCIT:C78253 DEPRESSED NCIT:C78253 A question about the usual severity of an individual's dizziness OR A disorder characterized by a disturbing sensation of lightheadedness, unsteadiness, giddiness, spinning or rocking OR A sensation of lightheadedness, unsteadiness, turning, spinning or rocking OR A question about whether an individual has or had dizziness OR A question about how often an individual feels or felt dizzy OR A question about an individual's distress from their dizziness. CCTO:000860 implies CCTO:000049 CCTO:000860 implies CCTO:001123 CCTO:000860(time_t t0) = EVENT_STATE(CCTO:000860, t0) NCI:CTCAE:10013573 NCIT:C125287 NCIT:C125319 NCIT:C125351 NCIT:C125409 NCIT:C37943 NCIT:C55385 UMLS:C0012833 UMLS:C0220870 UMLS:C1963093 Dizziness adverse event Dizzy Dizzy frequency Frequency of Dizziness Have been dizzy Have dizziness How much distress dizziness How often dizzy Lightheadedness Usual severity dizziness cancer_care_treatment_outcome CCTO:000860 Dizziness CCTO:000860 A question about the usual severity of an individual's dizziness OR A disorder characterized by a disturbing sensation of lightheadedness, unsteadiness, giddiness, spinning or rocking OR A sensation of lightheadedness, unsteadiness, turning, spinning or rocking OR A question about whether an individual has or had dizziness OR A question about how often an individual feels or felt dizzy OR A question about an individual's distress from their dizziness. NCI:CTCAE NCIT:C125287 NCIT:C125319 NCIT:C125351 NCIT:C125409 NCIT:C37943 Dizziness adverse event NCIT:C55385 Dizzy NCIT:C37943 Dizzy frequency NCIT:C125287 Frequency of Dizziness NCIT:C125287 Have been dizzy NCIT:C125409 Have dizziness NCIT:C125409 How much distress dizziness NCIT:C125351 How often dizzy NCIT:C125287 Lightheadedness NCIT:C37943 Usual severity dizziness NCIT:C125319 Slow and slurred speech resulting from inability to coordinate the muscles that are used in speech. Causes include brain damage, Parkinson disease, and developmental causes OR A disorder characterized by slow and slurred speech resulting from an inability to coordinate the muscles used in speech. CCTO:000861 implies CCTO:000049 CCTO:000861 implies CCTO:001123 CCTO:000861(time_t t0) = EVENT_STATE(CCTO:000861, t0) NCI:CTCAE:10013887 NCIT:C79549 UMLS:C0013362 cancer_care_treatment_outcome CCTO:000861 Dysarthria CCTO:000861 Slow and slurred speech resulting from inability to coordinate the muscles that are used in speech. Causes include brain damage, Parkinson disease, and developmental causes OR A disorder characterized by slow and slurred speech resulting from an inability to coordinate the muscles used in speech. NCI:CTCAE NCIT:C79549 A disorder characterized by distortion of sensory perception, resulting in an abnormal and unpleasant sensation OR Distortion of a sense resulting in an abnormal and unpleasant sensation, usually described as burning, tingling, or numbness. Causes include lesions of the nervous system. CCTO:000862 implies CCTO:000049 CCTO:000862 implies CCTO:001123 CCTO:000862(time_t t0) = EVENT_STATE(CCTO:000862, t0) NCI:CTCAE:10062872 NCIT:C28246 UMLS:C0392699 cancer_care_treatment_outcome CCTO:000862 Dysesthesia CCTO:000862 A disorder characterized by distortion of sensory perception, resulting in an abnormal and unpleasant sensation OR Distortion of a sense resulting in an abnormal and unpleasant sensation, usually described as burning, tingling, or numbness. Causes include lesions of the nervous system. NCI:CTCAE NCIT:C28246 Persistence of unpleasant taste OR A disorder characterized by abnormal sensual experience with the taste of foodstuffs; it can be related to a decrease in the sense of smell. CCTO:000863 implies CCTO:000049 CCTO:000863 implies CCTO:001123 CCTO:000863(time_t t0) = EVENT_STATE(CCTO:000863, t0) NCI:CTCAE:10013911 NCIT:C28145 UMLS:C0013378 parageusia cancer_care_treatment_outcome CCTO:000863 Dysgeusia CCTO:000863 Persistence of unpleasant taste OR A disorder characterized by abnormal sensual experience with the taste of foodstuffs; it can be related to a decrease in the sense of smell. NCI:CTCAE NCIT:C28145 parageusia NCIT:C28145 A disorder characterized by impairment of verbal communication skills, often resulting from brain damage OR Impairment of verbal communication skills, often resulting from brain damage. CCTO:000864 implies CCTO:000049 CCTO:000864 implies CCTO:001123 CCTO:000864(time_t t0) = EVENT_STATE(CCTO:000864, t0) NCI:CTCAE:10013951 NCIT:C35546 UMLS:C0973461 cancer_care_treatment_outcome CCTO:000864 Dysphasia CCTO:000864 A disorder characterized by impairment of verbal communication skills, often resulting from brain damage OR Impairment of verbal communication skills, often resulting from brain damage. NCI:CTCAE NCIT:C35546 Swelling due to an excessive accumulation of fluid in the brain OR A disorder characterized by swelling due to an excessive accumulation of fluid in the brain. CCTO:000865 implies CCTO:000049 CCTO:000865 implies CCTO:001123 CCTO:000865(time_t t0) = EVENT_STATE(CCTO:000865, t0) NCI:CTCAE:10014217 NCIT:C4909 UMLS:C0006114 Cerebral edema edema, cerebral cancer_care_treatment_outcome CCTO:000865 Edema cerebral CCTO:000865 Swelling due to an excessive accumulation of fluid in the brain OR A disorder characterized by swelling due to an excessive accumulation of fluid in the brain. NCI:CTCAE NCIT:C4909 Cerebral edema NCIT:C4909 edema, cerebral NCIT:C4909 A functional and/or structural disorder of the brain caused by diseases (e.g. liver disease, kidney disease), medications, chemicals, and injuries OR A disorder characterized by a pathologic process involving the brain. CCTO:000866 implies CCTO:000049 CCTO:000866 implies CCTO:001123 CCTO:000866(time_t t0) = EVENT_STATE(CCTO:000866, t0) NCI:CTCAE:10014625 NCIT:C26920 NCIT:C55390 UMLS:C0085584 UMLS:C1963101 Encephalopathy adverse event cancer_care_treatment_outcome CCTO:000866 Encephalopathy CCTO:000866 A functional and/or structural disorder of the brain caused by diseases (e.g. liver disease, kidney disease), medications, chemicals, and injuries OR A disorder characterized by a pathologic process involving the brain. NCI:CTCAE NCIT:C26920 Encephalopathy adverse event NCIT:C55390 A disorder characterized by abnormal, repetitive, involuntary muscle movements, frenzied speech and extreme restlessness OR A movement disorder caused by defects in the basal ganglia. The clinical manifestations include changes in the muscle tone, dyskinesia, and akinesia. Causes include vascular disorders, degenerative disorders, and antipsychotic drugs. CCTO:000867 implies CCTO:000049 CCTO:000867 implies CCTO:001123 CCTO:000867(time_t t0) = EVENT_STATE(CCTO:000867, t0) NCI:CTCAE:10015832 NCIT:C79593 UMLS:C0015371 cancer_care_treatment_outcome CCTO:000867 Extrapyramidal disorder CCTO:000867 A disorder characterized by abnormal, repetitive, involuntary muscle movements, frenzied speech and extreme restlessness OR A movement disorder caused by defects in the basal ganglia. The clinical manifestations include changes in the muscle tone, dyskinesia, and akinesia. Causes include vascular disorders, degenerative disorders, and antipsychotic drugs. NCI:CTCAE NCIT:C79593 A reduction in the strength of the facial muscles OR A disorder characterized by a reduction in the strength of the facial muscles. CCTO:000868 implies CCTO:000049 CCTO:000868 implies CCTO:001123 CCTO:000868(time_t t0) = EVENT_STATE(CCTO:000868, t0) NCI:CTCAE:10051272 NCIT:C78290 UMLS:C0427055 cancer_care_treatment_outcome CCTO:000868 Facial muscle weakness CCTO:000868 A reduction in the strength of the facial muscles OR A disorder characterized by a reduction in the strength of the facial muscles. NCI:CTCAE NCIT:C78290 A non-neoplastic or neoplastic disorder affecting the facial nerve (seventh cranial nerve) OR A disorder characterized by involvement of the facial nerve (seventh cranial nerve). CCTO:000869 implies CCTO:000049 CCTO:000869 implies CCTO:001123 CCTO:000869(time_t t0) = EVENT_STATE(CCTO:000869, t0) NCI:CTCAE:10061457 NCIT:C27594 UMLS:C0015464 UMLS:C0015469 cancer_care_treatment_outcome CCTO:000869 Facial nerve disorder CCTO:000869 A non-neoplastic or neoplastic disorder affecting the facial nerve (seventh cranial nerve) OR A disorder characterized by involvement of the facial nerve (seventh cranial nerve). NCI:CTCAE NCIT:C27594 A disorder characterized by involvement of the glossopharyngeal nerve (ninth cranial nerve) OR A non-neoplastic or neoplastic disorder affecting the glossopharyngeal nerve (ninth cranial nerve). CCTO:000870 implies CCTO:000049 CCTO:000870 implies CCTO:001123 CCTO:000870(time_t t0) = EVENT_STATE(CCTO:000870, t0) NCI:CTCAE:10061185 NCIT:C27211 UMLS:C0751941 IX Nerve Disorder Ninth nerve disorder cancer_care_treatment_outcome CCTO:000870 Glossopharyngeal nerve disorder CCTO:000870 A disorder characterized by involvement of the glossopharyngeal nerve (ninth cranial nerve) OR A non-neoplastic or neoplastic disorder affecting the glossopharyngeal nerve (ninth cranial nerve). NCI:CTCAE NCIT:C27211 IX Nerve Disorder NCIT:C27211 Ninth nerve disorder NCIT:C27211 A disorder characterized by a sensation of marked discomfort in various parts of the head, not confined to the area of distribution of any nerve OR Pain in various parts of the head, not confined to the area of distribution of any nerve. CCTO:000871 implies CCTO:000049 CCTO:000871 implies CCTO:001123 CCTO:000871(time_t t0) = EVENT_STATE(CCTO:000871, t0) NCI:CTCAE:10019211 NCIT:C34661 UMLS:C0018681 cancer_care_treatment_outcome CCTO:000871 Headache CCTO:000871 A disorder characterized by a sensation of marked discomfort in various parts of the head, not confined to the area of distribution of any nerve OR Pain in various parts of the head, not confined to the area of distribution of any nerve. NCI:CTCAE NCIT:C34661 A disorder characterized by an abnormal increase of cerebrospinal fluid in the ventricles of the brain OR A disorder characterized by an abnormal increase of cerebrospinal fluid in the ventricles of the brain. CCTO:000872 implies CCTO:000049 CCTO:000872 implies CCTO:001123 CCTO:000872(time_t t0) = EVENT_STATE(CCTO:000872, t0) NCI:CTCAE:10020508 NCIT:C3111 NCIT:C55401 UMLS:C0020255 UMLS:C1963137 Hydrocephalus adverse event cancer_care_treatment_outcome CCTO:000872 Hydrocephalus CCTO:000872 A disorder characterized by an abnormal increase of cerebrospinal fluid in the ventricles of the brain OR A disorder characterized by an abnormal increase of cerebrospinal fluid in the ventricles of the brain. NCI:CTCAE NCIT:C3111 Hydrocephalus adverse event NCIT:C55401 A disorder characterized by characterized by excessive sleepiness during the daytime OR A sleep disorder characterized by excessive sleepiness. CCTO:000873 implies CCTO:000049 CCTO:000873 implies CCTO:001123 CCTO:000873(time_t t0) = EVENT_STATE(CCTO:000873, t0) NCI:CTCAE:10020765 NCIT:C78346 UMLS:C0917799 cancer_care_treatment_outcome CCTO:000873 Hypersomnia CCTO:000873 A disorder characterized by characterized by excessive sleepiness during the daytime OR A sleep disorder characterized by excessive sleepiness. NCI:CTCAE NCIT:C78346 A non-neoplastic or neoplastic disorder affecting the hypoglossal nerve (twelfth cranial nerve) OR A disorder characterized by involvement of the hypoglossal nerve (twelfth cranial nerve). CCTO:000874 implies CCTO:000049 CCTO:000874 implies CCTO:001123 CCTO:000874(time_t t0) = EVENT_STATE(CCTO:000874, t0) NCI:CTCAE:10061212 NCIT:C26954 UMLS:C0152181 Disorder of XII Nerve Disorder of the XII Nerve Twelfth nerve disorder cancer_care_treatment_outcome CCTO:000874 Hypoglossal nerve disorder CCTO:000874 A non-neoplastic or neoplastic disorder affecting the hypoglossal nerve (twelfth cranial nerve) OR A disorder characterized by involvement of the hypoglossal nerve (twelfth cranial nerve). NCI:CTCAE NCIT:C26954 Disorder of XII Nerve NCIT:C26954 Disorder of the XII Nerve NCIT:C26954 Twelfth nerve disorder NCIT:C26954 A disorder characterized by bleeding from the cranium OR Bleeding within the cranium. CCTO:000875 implies CCTO:000049 CCTO:000875 implies CCTO:001123 CCTO:000875(time_t t0) = EVENT_STATE(CCTO:000875, t0) NCI:CTCAE:10022763 NCIT:C50438 UMLS:C0151699 Bleeding, intracranial Hemorrhage, intracranial Intracranial bleeding cancer_care_treatment_outcome CCTO:000875 Intracranial hemorrhage CCTO:000875 A disorder characterized by bleeding from the cranium OR Bleeding within the cranium. NCI:CTCAE NCIT:C50438 Bleeding, intracranial NCIT:C50438 Hemorrhage, intracranial NCIT:C50438 Intracranial bleeding NCIT:C50438 A disorder characterized by a decrease or absence of blood supply to the brain caused by obstruction (thrombosis or embolism) of an artery resulting in neurological damage OR Diminished or absent blood supply to the brain caused by obstruction (thrombosis or embolism) of an artery resulting in neurologic damage. CCTO:000876 implies CCTO:000049 CCTO:000876 implies CCTO:001123 CCTO:000876(time_t t0) = EVENT_STATE(CCTO:000876, t0) NCI:CTCAE:10023030 NCIT:C78394 UMLS:C0917798 Cerebrovascular ischemia cancer_care_treatment_outcome CCTO:000876 Ischemia cerebrovascular CCTO:000876 A disorder characterized by a decrease or absence of blood supply to the brain caused by obstruction (thrombosis or embolism) of an artery resulting in neurological damage OR Diminished or absent blood supply to the brain caused by obstruction (thrombosis or embolism) of an artery resulting in neurologic damage. NCI:CTCAE NCIT:C78394 Cerebrovascular ischemia NCIT:C78394 A non-neoplastic or neoplastic disorder affecting the trochlear nerve (IVth cranial nerve) OR A disorder characterized by involvement of the trochlear nerve (fourth cranial nerve). CCTO:000877 implies CCTO:000049 CCTO:000877 implies CCTO:001123 CCTO:000877(time_t t0) = EVENT_STATE(CCTO:000877, t0) NCI:CTCAE:10065836 NCIT:C78395 UMLS:C0271375 IVth Cranial Nerve Disorder Trochlear nerve disorder cancer_care_treatment_outcome CCTO:000877 IVth nerve disorder CCTO:000877 A non-neoplastic or neoplastic disorder affecting the trochlear nerve (IVth cranial nerve) OR A disorder characterized by involvement of the trochlear nerve (fourth cranial nerve). NCI:CTCAE NCIT:C78395 IVth Cranial Nerve Disorder NCIT:C78395 Trochlear nerve disorder NCIT:C78395 Decreased consciousness characterized by mental and physical inertness OR A disorder characterized by a decrease in consciousness characterized by mental and physical inertness. CCTO:000878 implies CCTO:000049 CCTO:000878 implies CCTO:001123 CCTO:000878(time_t t0) = EVENT_STATE(CCTO:000878, t0) NCI:CTCAE:10024264 NCIT:C78416 UMLS:C0023380 UMLS:C0085632 Listless cancer_care_treatment_outcome CCTO:000878 Lethargy CCTO:000878 Decreased consciousness characterized by mental and physical inertness OR A disorder characterized by a decrease in consciousness characterized by mental and physical inertness. NCI:CTCAE NCIT:C78416 Listless NCIT:C78416 White matter changes first described in children with leukemia, associated with radiation and chemotherapy injury, often associated with methotrexate; pathologically characterised by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation OR A disorder characterized by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation. CCTO:000879 implies CCTO:000049 CCTO:000879 implies CCTO:001123 CCTO:000879(time_t t0) = EVENT_STATE(CCTO:000879, t0) NCI:CTCAE:10024382 NCIT:C27059 UMLS:C0270612 cancer_care_treatment_outcome CCTO:000879 Leukoencephalopathy CCTO:000879 White matter changes first described in children with leukemia, associated with radiation and chemotherapy injury, often associated with methotrexate; pathologically characterised by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation OR A disorder characterized by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation. NCI:CTCAE NCIT:C27059 Deterioration in memory function OR A disorder characterized by a deterioration in memory function. CCTO:000880 implies CCTO:000049 CCTO:000880 implies CCTO:001123 CCTO:000880(time_t t0) = EVENT_STATE(CCTO:000880, t0) NCI:CTCAE:10027175 NCIT:C55427 NCIT:C78444 UMLS:C0233794 UMLS:C1963167 Memory impairment adverse event cancer_care_treatment_outcome CCTO:000880 Memory impairment CCTO:000880 Deterioration in memory function OR A disorder characterized by a deterioration in memory function. NCI:CTCAE NCIT:C78444 Memory impairment adverse event NCIT:C55427 The symptoms of neck stiffness, headache, and photophobia resulting from meningeal irritation. Causes include subarachnoid hemorrhage and acute febrile diseases OR A disorder characterized by neck stiffness, headache, and photophobia resulting from irritation of the cerebral meninges. CCTO:000881 implies CCTO:000049 CCTO:000881 implies CCTO:001123 CCTO:000881(time_t t0) = EVENT_STATE(CCTO:000881, t0) NCI:CTCAE:10027198 NCIT:C79694 UMLS:C0025287 meningeal syndrome cancer_care_treatment_outcome CCTO:000881 Meningismus CCTO:000881 The symptoms of neck stiffness, headache, and photophobia resulting from meningeal irritation. Causes include subarachnoid hemorrhage and acute febrile diseases OR A disorder characterized by neck stiffness, headache, and photophobia resulting from irritation of the cerebral meninges. NCI:CTCAE NCIT:C79694 meningeal syndrome NCIT:C79694 A disorder characterized by uncontrolled and purposeless movements OR Uncontrolled and purposeless movements. CCTO:000882 implies CCTO:000049 CCTO:000882 implies CCTO:001123 CCTO:000882(time_t t0) = EVENT_STATE(CCTO:000882, t0) NCI:CTCAE:10028041 NCIT:C78453 UMLS:C0427086 Involuntary movements cancer_care_treatment_outcome CCTO:000882 Movements involuntary CCTO:000882 A disorder characterized by uncontrolled and purposeless movements OR Uncontrolled and purposeless movements. NCI:CTCAE NCIT:C78453 Involuntary movements NCIT:C78453 An inflammatory process affecting the spinal cord. Causes include viral infections, autoimmune disorders, vascular disorders, and toxic agents. Symptoms include weakness, paresthesia, sensory loss, pain, and incontinence OR A disorder characterized by inflammation involving the spinal cord. Symptoms include weakness, paresthesia, sensory loss, marked discomfort and incontinence. CCTO:000883 implies CCTO:000049 CCTO:000883 implies CCTO:001123 CCTO:000883(time_t t0) = EVENT_STATE(CCTO:000883, t0) NCI:CTCAE:10028524 NCIT:C26832 NCIT:C55459 UMLS:C0026975 UMLS:C1963178 Myelitis adverse event cancer_care_treatment_outcome CCTO:000883 Myelitis CCTO:000883 An inflammatory process affecting the spinal cord. Causes include viral infections, autoimmune disorders, vascular disorders, and toxic agents. Symptoms include weakness, paresthesia, sensory loss, pain, and incontinence OR A disorder characterized by inflammation involving the spinal cord. Symptoms include weakness, paresthesia, sensory loss, marked discomfort and incontinence. NCI:CTCAE NCIT:C26832 Myelitis adverse event NCIT:C55459 Intense painful sensation along a nerve or group of nerves. It is caused by irritation or trauma to a nerve or inflammation of a nerve OR A disorder characterized by intense painful sensation along a nerve or group of nerves. CCTO:000884 implies CCTO:000049 CCTO:000884 implies CCTO:001123 CCTO:000884(time_t t0) = EVENT_STATE(CCTO:000884, t0) NCI:CTCAE:10029223 NCIT:C79695 UMLS:C0027796 cancer_care_treatment_outcome CCTO:000884 Neuralgia CCTO:000884 Intense painful sensation along a nerve or group of nerves. It is caused by irritation or trauma to a nerve or inflammation of a nerve OR A disorder characterized by intense painful sensation along a nerve or group of nerves. NCI:CTCAE NCIT:C79695 Involuntary movements of the eyeballs. The presence or absence of nystagmus is often used in the diagnosis of a variety of neurological and visual disorders OR A disorder characterized by involuntary movements of the eyeballs. CCTO:000885 implies CCTO:000049 CCTO:000885 implies CCTO:001123 CCTO:000885(time_t t0) = EVENT_STATE(CCTO:000885, t0) NCI:CTCAE:10029864 NCIT:C3282 NCIT:C55857 UMLS:C0028738 UMLS:C1963184 Nystagmus adverse event cancer_care_treatment_outcome CCTO:000885 Nystagmus CCTO:000885 Involuntary movements of the eyeballs. The presence or absence of nystagmus is often used in the diagnosis of a variety of neurological and visual disorders OR A disorder characterized by involuntary movements of the eyeballs. NCI:CTCAE NCIT:C3282 Nystagmus adverse event NCIT:C55857 A non-neoplastic or neoplastic disorder affecting the oculomotor nerve (third cranial nerve) OR A disorder characterized by involvement of the oculomotor nerve (third cranial nerve). CCTO:000886 implies CCTO:000049 CCTO:000886 implies CCTO:001123 CCTO:000886(time_t t0) = EVENT_STATE(CCTO:000886, t0) NCI:CTCAE:10053661 NCIT:C27598 UMLS:C0028866 UMLS:C0271353 cancer_care_treatment_outcome CCTO:000886 Oculomotor nerve disorder CCTO:000886 A non-neoplastic or neoplastic disorder affecting the oculomotor nerve (third cranial nerve) OR A disorder characterized by involvement of the oculomotor nerve (third cranial nerve). NCI:CTCAE NCIT:C27598 A disorder characterized by involvement of the olfactory nerve (first cranial nerve) OR A non-neoplastic or neoplastic disorder affecting the olfactory nerve (first cranial nerve). CCTO:000887 implies CCTO:000049 CCTO:000887 implies CCTO:001123 CCTO:000887(time_t t0) = EVENT_STATE(CCTO:000887, t0) NCI:CTCAE:10056388 NCIT:C27210 UMLS:C0751937 Disorder of 1st Nerve Disorder of the 1st Nerve cancer_care_treatment_outcome CCTO:000887 Olfactory nerve disorder CCTO:000887 A disorder characterized by involvement of the olfactory nerve (first cranial nerve) OR A non-neoplastic or neoplastic disorder affecting the olfactory nerve (first cranial nerve). NCI:CTCAE NCIT:C27210 Disorder of 1st Nerve NCIT:C27210 Disorder of the 1st Nerve NCIT:C27210 Abnormal cutaneous sensations of tingling, numbness, pressure, cold, and warmth that an individual experiences without the presence of a stimulus. It results from functional disturbances of sensory neurons. Causes include peripheral vascular disease, peripheral neuropathy, and nerve damage OR A disorder characterized by functional disturbances of sensory neurons resulting in abnormal cutaneous sensations of tingling, numbness, pressure, cold, and warmth that are experienced in the absence of a stimulus. CCTO:000888 implies CCTO:000049 CCTO:000888 implies CCTO:001123 CCTO:000888(time_t t0) = EVENT_STATE(CCTO:000888, t0) NCI:CTCAE:10033987 NCIT:C28177 UMLS:C0030554 cancer_care_treatment_outcome CCTO:000888 Paresthesia CCTO:000888 Abnormal cutaneous sensations of tingling, numbness, pressure, cold, and warmth that an individual experiences without the presence of a stimulus. It results from functional disturbances of sensory neurons. Causes include peripheral vascular disease, peripheral neuropathy, and nerve damage OR A disorder characterized by functional disturbances of sensory neurons resulting in abnormal cutaneous sensations of tingling, numbness, pressure, cold, and warmth that are experienced in the absence of a stimulus. NCI:CTCAE NCIT:C28177 A disorder characterized by inflammation or degeneration of the peripheral motor nerves OR Inflammation or degeneration of the peripheral motor nerves. CCTO:000889 implies CCTO:000049 CCTO:000889 implies CCTO:001123 CCTO:000889(time_t t0) = EVENT_STATE(CCTO:000889, t0) NCI:CTCAE:10034580 NCIT:C3500 UMLS:C0235025 cancer_care_treatment_outcome CCTO:000889 Peripheral motor neuropathy CCTO:000889 A disorder characterized by inflammation or degeneration of the peripheral motor nerves OR Inflammation or degeneration of the peripheral motor nerves. NCI:CTCAE NCIT:C3500 Inflammation or degeneration of the sensory nerves OR A disorder characterized by inflammation or degeneration of the peripheral sensory nerves. CCTO:000890 implies CCTO:000049 CCTO:000890 implies CCTO:001123 CCTO:000890(time_t t0) = EVENT_STATE(CCTO:000890, t0) NCI:CTCAE:10034620 NCIT:C3501 UMLS:C0151313 cancer_care_treatment_outcome CCTO:000890 Peripheral sensory neuropathy CCTO:000890 Inflammation or degeneration of the sensory nerves OR A disorder characterized by inflammation or degeneration of the peripheral sensory nerves. NCI:CTCAE NCIT:C3501 A disorder characterized by marked discomfort related to a limb or an organ that is removed from or is not physically part of the body OR Painful sensation related to a limb or an organ that is removed from or is not physically part of the body. CCTO:000891 implies CCTO:000107 CCTO:000891 implies CCTO:001123 CCTO:000891(time_t t0) = EVENT_STATE(CCTO:000891, t0) NCI:CTCAE:10056238 NCIT:C79703 UMLS:C0031315 UMLS:C3495442 cancer_care_treatment_outcome CCTO:000891 Phantom pain CCTO:000891 A disorder characterized by marked discomfort related to a limb or an organ that is removed from or is not physically part of the body OR Painful sensation related to a limb or an organ that is removed from or is not physically part of the body. NCI:CTCAE NCIT:C79703 A disorder characterized by an episode of lightheadedness and dizziness which may precede an episode of syncope OR An episode of lightheadedness and dizziness which may precede an episode of syncope. CCTO:000892 implies CCTO:000049 CCTO:000892 implies CCTO:001123 CCTO:000892(time_t t0) = EVENT_STATE(CCTO:000892, t0) NCI:CTCAE:10036653 NCIT:C80100 UMLS:C0700200 cancer_care_treatment_outcome CCTO:000892 Presyncope CCTO:000892 A disorder characterized by an episode of lightheadedness and dizziness which may precede an episode of syncope OR An episode of lightheadedness and dizziness which may precede an episode of syncope. NCI:CTCAE NCIT:C80100 Dysfunction of the corticospinal (pyramidal) tracts of the spinal cord. Symptoms include increased muscle tone in the lower extremities, hyperreflexia, positive Babinski, and decreased fine motor coordination OR A disorder characterized by dysfunction of the corticospinal (pyramidal) tracts of the spinal cord. Symptoms include an increase in the muscle tone in the lower extremities, hyperreflexia, positive Babinski and a decrease in fine motor coordination. CCTO:000893 implies CCTO:000049 CCTO:000893 implies CCTO:001123 CCTO:000893(time_t t0) = EVENT_STATE(CCTO:000893, t0) NCI:CTCAE:10063636 NCIT:C43245 UMLS:C1504405 Dysfunction of the Pyramidal Tract Pyramidal tract dysfunction cancer_care_treatment_outcome CCTO:000893 Pyramidal tract syndrome CCTO:000893 Dysfunction of the corticospinal (pyramidal) tracts of the spinal cord. Symptoms include increased muscle tone in the lower extremities, hyperreflexia, positive Babinski, and decreased fine motor coordination OR A disorder characterized by dysfunction of the corticospinal (pyramidal) tracts of the spinal cord. Symptoms include an increase in the muscle tone in the lower extremities, hyperreflexia, positive Babinski and a decrease in fine motor coordination. NCI:CTCAE NCIT:C43245 Dysfunction of the Pyramidal Tract NCIT:C43245 Pyramidal tract dysfunction NCIT:C43245 An inflammatory process affecting a nerve root. Patients experience pain radiating along a nerve path because of spinal pressure on the nerve root that connects to the nerve path OR A disorder characterized by inflammation involving a nerve root. Patients experience marked discomfort radiating along a nerve path because of spinal pressure on the connecting nerve root. CCTO:000894 implies CCTO:000049 CCTO:000894 implies CCTO:001123 CCTO:000894(time_t t0) = EVENT_STATE(CCTO:000894, t0) NCI:CTCAE:10061928 NCIT:C78581 UMLS:C0034544 cancer_care_treatment_outcome CCTO:000894 Radiculitis CCTO:000894 An inflammatory process affecting a nerve root. Patients experience pain radiating along a nerve path because of spinal pressure on the nerve root that connects to the nerve path OR A disorder characterized by inflammation involving a nerve root. Patients experience marked discomfort radiating along a nerve path because of spinal pressure on the connecting nerve root. NCI:CTCAE NCIT:C78581 Paralysis of the recurrent laryngeal nerve. Causes include surgical and non-surgical traumas, neoplasms (e.g., lung carcinoma), and inflammatory neuritis OR A disorder characterized by paralysis of the recurrent laryngeal nerve. CCTO:000895 implies CCTO:000049 CCTO:000895 implies CCTO:001123 CCTO:000895(time_t t0) = EVENT_STATE(CCTO:000895, t0) NCI:CTCAE:10038130 NCIT:C78592 UMLS:C0542142 Recurrent laryngeal nerve paralysis Vagus nerve laryngeal paralysis cancer_care_treatment_outcome CCTO:000895 Recurrent laryngeal nerve palsy CCTO:000895 Paralysis of the recurrent laryngeal nerve. Causes include surgical and non-surgical traumas, neoplasms (e.g., lung carcinoma), and inflammatory neuritis OR A disorder characterized by paralysis of the recurrent laryngeal nerve. NCI:CTCAE NCIT:C78592 Recurrent laryngeal nerve paralysis NCIT:C78592 Vagus nerve laryngeal paralysis NCIT:C78592 A disorder characterized by headaches, mental status changes, visual disturbances, and seizures associated with imaging findings of posterior leukoencephalopathy. It has been observed in association with hypertensive encephalopathy, eclampsia, and immunosuppressive and cytotoxic drug treatment. It is an acute or subacute reversible condition OR An acute or subacute reversible condition characterized by headaches, mental status changes, visual disturbances, and seizures associated with imaging findings of posterior leukoencephalopathy. It has been observed in association with hypertensive encephalopathy, eclampsia, and immunosuppressive and cytotoxic drug treatment. CCTO:000896 implies CCTO:000049 CCTO:000896 implies CCTO:001123 CCTO:000896(time_t t0) = EVENT_STATE(CCTO:000896, t0) NCI:CTCAE:10063761 NCIT:C78598 UMLS:C0033095 UMLS:C1822756 UMLS:C3160858 PRES Posterior reversible encephalopathy syndrome RPLE Reversible occipital parietal encephalopathy Reversible posterior cerebral edema syndrome cancer_care_treatment_outcome CCTO:000896 Reversible posterior leukoencephalopathy syndrome CCTO:000896 A disorder characterized by headaches, mental status changes, visual disturbances, and seizures associated with imaging findings of posterior leukoencephalopathy. It has been observed in association with hypertensive encephalopathy, eclampsia, and immunosuppressive and cytotoxic drug treatment. It is an acute or subacute reversible condition OR An acute or subacute reversible condition characterized by headaches, mental status changes, visual disturbances, and seizures associated with imaging findings of posterior leukoencephalopathy. It has been observed in association with hypertensive encephalopathy, eclampsia, and immunosuppressive and cytotoxic drug treatment. NCI:CTCAE NCIT:C78598 PRES NCIT:C78598 Posterior reversible encephalopathy syndrome NCIT:C78598 RPLE NCIT:C78598 Reversible occipital parietal encephalopathy NCIT:C78598 Reversible posterior cerebral edema syndrome NCIT:C78598 A disorder characterized by a sudden, involuntary skeletal muscular contractions of cerebral or brain stem origin OR Sudden, involuntary skeletal muscular contractions of cerebral or brain stem origin. CCTO:000897 implies CCTO:000049 CCTO:000897 implies CCTO:001123 CCTO:000897(time_t t0) = EVENT_STATE(CCTO:000897, t0) NCI:CTCAE:10039906 NCIT:C2962 NCIT:C55578 UMLS:C0036572 UMLS:C1959629 Convulsion Seizure adverse event Seizures cancer_care_treatment_outcome CCTO:000897 Seizure CCTO:000897 A disorder characterized by a sudden, involuntary skeletal muscular contractions of cerebral or brain stem origin OR Sudden, involuntary skeletal muscular contractions of cerebral or brain stem origin. NCI:CTCAE NCIT:C2962 Convulsion NCIT:C2962 Seizure adverse event NCIT:C55578 Seizures NCIT:C2962 Painful sensation in the face, between the eyes, or upper teeth originating from the sinuses. It is usually caused by sinus infections OR A disorder characterized by marked discomfort in the face, between the eyes, or upper teeth originating from the sinuses. CCTO:000898 implies CCTO:000107 CCTO:000898 implies CCTO:001123 CCTO:000898(time_t t0) = EVENT_STATE(CCTO:000898, t0) NCI:CTCAE:10040747 NCIT:C56220 NCIT:C78609 UMLS:C0522251 UMLS:C1963236 Sinus pain adverse event cancer_care_treatment_outcome CCTO:000898 Sinus pain CCTO:000898 Painful sensation in the face, between the eyes, or upper teeth originating from the sinuses. It is usually caused by sinus infections OR A disorder characterized by marked discomfort in the face, between the eyes, or upper teeth originating from the sinuses. NCI:CTCAE NCIT:C78609 Sinus pain adverse event NCIT:C56220 A disorder characterized by characterized by excessive sleepiness and drowsiness OR A sleep disorder characterized by excessive sleepiness and drowsiness. CCTO:000899 implies CCTO:000049 CCTO:000899 implies CCTO:001123 CCTO:000899(time_t t0) = EVENT_STATE(CCTO:000899, t0) NCI:CTCAE:10041349 NCIT:C26754 UMLS:C2830004 cancer_care_treatment_outcome CCTO:000899 Somnolence CCTO:000899 A disorder characterized by characterized by excessive sleepiness and drowsiness OR A sleep disorder characterized by excessive sleepiness and drowsiness. NCI:CTCAE NCIT:C26754 Increased involuntary muscle tone caused by central nervous system disorders that affect the regions interfering with voluntary movement. It results in gait, movement, and speech disturbances. Representative examples of disorders causing spasticity include brain or spinal cord injury, and multiple sclerosis OR A disorder characterized by increased involuntary muscle tone that affects the regions interfering with voluntary movement. It results in gait, movement, and speech disturbances. CCTO:000900 implies CCTO:000049 CCTO:000900 implies CCTO:001123 CCTO:000900(time_t t0) = EVENT_STATE(CCTO:000900, t0) NCI:CTCAE:10041416 NCIT:C79750 UMLS:C0026838 UMLS:C0443306 Spastic cancer_care_treatment_outcome CCTO:000900 Spasticity CCTO:000900 Increased involuntary muscle tone caused by central nervous system disorders that affect the regions interfering with voluntary movement. It results in gait, movement, and speech disturbances. Representative examples of disorders causing spasticity include brain or spinal cord injury, and multiple sclerosis OR A disorder characterized by increased involuntary muscle tone that affects the regions interfering with voluntary movement. It results in gait, movement, and speech disturbances. NCI:CTCAE NCIT:C79750 Spastic NCIT:C79750 A disorder characterized by a sudden loss of sensory function due to an intracranial vascular event OR A sudden loss of neurological function secondary to hemorrhage or ischemia in the brain parenchyma due to a vascular event. CCTO:000901 implies CCTO:000049 CCTO:000901 implies CCTO:001123 CCTO:000901(time_t t0) = EVENT_STATE(CCTO:000901, t0) NCI:CTCAE:10042244 NCIT:C3390 UMLS:C0001365 UMLS:C0007785 UMLS:C0038454 UMLS:C0054889 UMLS:C1263853 CVA CVA, Cerebrovascular Accident Cerebral infarction Cerebrovascular Accident, (CVA) Cerebrovascular accident Stroke syndrome Syndrome, stroke UNDETERMINED STROKE cancer_care_treatment_outcome CCTO:000901 Stroke CCTO:000901 A disorder characterized by a sudden loss of sensory function due to an intracranial vascular event OR A sudden loss of neurological function secondary to hemorrhage or ischemia in the brain parenchyma due to a vascular event. NCI:CTCAE NCIT:C3390 CVA NCIT:C3390 CVA, Cerebrovascular Accident NCIT:C3390 Cerebral infarction NCIT:C3390 Cerebrovascular Accident, (CVA) NCIT:C3390 Cerebrovascular accident NCIT:C3390 Stroke syndrome NCIT:C3390 Syndrome, stroke NCIT:C3390 UNDETERMINED STROKE NCIT:C3390 A spontaneous loss of consciousness caused by insufficient blood supply to the brain OR A disorder characterized by spontaneous loss of consciousness caused by insufficient blood supply to the brain. CCTO:000902 implies CCTO:000049 CCTO:000902 implies CCTO:001123 CCTO:000902(time_t t0) = EVENT_STATE(CCTO:000902, t0) NCI:CTCAE:10042772 NCIT:C35053 UMLS:C0039070 UMLS:C3541349 Faint Fainting cancer_care_treatment_outcome CCTO:000902 Syncope CCTO:000902 A spontaneous loss of consciousness caused by insufficient blood supply to the brain OR A disorder characterized by spontaneous loss of consciousness caused by insufficient blood supply to the brain. NCI:CTCAE NCIT:C35053 Faint NCIT:C35053 Fainting NCIT:C35053 A disorder characterized by a brief attack (less than 24 hours) of cerebral dysfunction of vascular origin, with no persistent neurological deficit OR A brief attack (from a few minutes to an hour) of cerebral dysfunction of vascular origin, with no persistent neurological deficit. CCTO:000903 implies CCTO:000049 CCTO:000903 implies CCTO:001123 CCTO:000903(time_t t0) = EVENT_STATE(CCTO:000903, t0) NCI:CTCAE:10044391 NCIT:C50781 UMLS:C0007787 UMLS:C1054154 Attack, transient ischemic Ischemic attack, transient TIA Transient ischemic attack cancer_care_treatment_outcome CCTO:000903 Transient ischemic attacks CCTO:000903 A disorder characterized by a brief attack (less than 24 hours) of cerebral dysfunction of vascular origin, with no persistent neurological deficit OR A brief attack (from a few minutes to an hour) of cerebral dysfunction of vascular origin, with no persistent neurological deficit. NCI:CTCAE NCIT:C50781 Attack, transient ischemic NCIT:C50781 Ischemic attack, transient NCIT:C50781 TIA NCIT:C50781 Transient ischemic attack NCIT:C50781 The shaking movement of the whole body or just a certain part of it, often caused by problems of the neurons responsible for muscle action OR A disorder characterized by the uncontrolled shaking movement of the whole body or individual parts. CCTO:000904 implies CCTO:000049 CCTO:000904 implies CCTO:001123 CCTO:000904(time_t t0) = EVENT_STATE(CCTO:000904, t0) NCI:CTCAE:10044565 NCIT:C38038 NCIT:C55596 UMLS:C0040822 UMLS:C1963252 Shaking Shaking/tremors Tremor adverse event Tremors/shaking cancer_care_treatment_outcome CCTO:000904 Tremor CCTO:000904 The shaking movement of the whole body or just a certain part of it, often caused by problems of the neurons responsible for muscle action OR A disorder characterized by the uncontrolled shaking movement of the whole body or individual parts. NCI:CTCAE NCIT:C38038 Shaking NCIT:C38038 Shaking/tremors NCIT:C38038 Tremor adverse event NCIT:C55596 Tremors/shaking NCIT:C38038 A non-neoplastic or neoplastic disorder affecting the trigeminal nerve (fifth cranial nerve) OR A disorder characterized by involvement of the trigeminal nerve (fifth cranial nerve). CCTO:000905 implies CCTO:000049 CCTO:000905 implies CCTO:001123 CCTO:000905(time_t t0) = EVENT_STATE(CCTO:000905, t0) NCI:CTCAE:10060890 NCIT:C26952 UMLS:C0152177 cancer_care_treatment_outcome CCTO:000905 Trigeminal nerve disorder CCTO:000905 A non-neoplastic or neoplastic disorder affecting the trigeminal nerve (fifth cranial nerve) OR A disorder characterized by involvement of the trigeminal nerve (fifth cranial nerve). NCI:CTCAE NCIT:C26952 A disorder characterized by involvement of the vagus nerve (tenth cranial nerve) OR A non-neoplastic or neoplastic disorder affecting the vagus nerve (tenth cranial nerve). CCTO:000906 implies CCTO:000049 CCTO:000906 implies CCTO:001123 CCTO:000906(time_t t0) = EVENT_STATE(CCTO:000906, t0) NCI:CTCAE:10061403 NCIT:C27591 UMLS:C0152179 cancer_care_treatment_outcome CCTO:000906 Vagus nerve disorder CCTO:000906 A disorder characterized by involvement of the vagus nerve (tenth cranial nerve) OR A non-neoplastic or neoplastic disorder affecting the vagus nerve (tenth cranial nerve). NCI:CTCAE NCIT:C27591 A disorder characterized by a sudden drop of the blood pressure, bradycardia, and peripheral vasodilation that may lead to loss of consciousness. It results from an increase in the stimulation of the vagus nerve OR Sudden drop of the blood pressure, bradycardia, and peripheral vasodilation that may lead to loss of consciousness. It results from an increase in the activity of the vagus nerve. It may be triggered by emotions of fear or pain or gastrointestinal upset and may be relieved by lying down while keeping the legs elevated. CCTO:000907 implies CCTO:000049 CCTO:000907 implies CCTO:001123 CCTO:000907(time_t t0) = EVENT_STATE(CCTO:000907, t0) NCI:CTCAE:10047166 NCIT:C50798 UMLS:C0042420 UMLS:C1710621 Vaso-vagal response Vasovagal response cancer_care_treatment_outcome CCTO:000907 Vasovagal reaction CCTO:000907 A disorder characterized by a sudden drop of the blood pressure, bradycardia, and peripheral vasodilation that may lead to loss of consciousness. It results from an increase in the stimulation of the vagus nerve OR Sudden drop of the blood pressure, bradycardia, and peripheral vasodilation that may lead to loss of consciousness. It results from an increase in the activity of the vagus nerve. It may be triggered by emotions of fear or pain or gastrointestinal upset and may be relieved by lying down while keeping the legs elevated. NCI:CTCAE NCIT:C50798 Vaso-vagal response NCIT:C50798 Vasovagal response NCIT:C50798 Death of a fetus after 10 weeks gestation OR A disorder characterized by death in utero; failure of the product of conception to show evidence of respiration, heartbeat, or definite movement of a voluntary muscle after expulsion from the uterus, without possibility of resuscitation. CCTO:000908 implies CCTO:000049 CCTO:000908 implies CCTO:001124 CCTO:000908(time_t t0) = EVENT_STATE(CCTO:000908, t0) NCI:CTCAE:10016479 NCIT:C50620 UMLS:C0015927 UMLS:C0021900 UMLS:C0595939 Death, intrauterine fetal Fetal death, intrauterine Fetal demise INTRAUTERINE DEATH IUD Intrauterine fetal death cancer_care_treatment_outcome CCTO:000908 Fetal death CCTO:000908 Death of a fetus after 10 weeks gestation OR A disorder characterized by death in utero; failure of the product of conception to show evidence of respiration, heartbeat, or definite movement of a voluntary muscle after expulsion from the uterus, without possibility of resuscitation. NCI:CTCAE NCIT:C50620 Death, intrauterine fetal NCIT:C50620 Fetal death, intrauterine NCIT:C50620 Fetal demise NCIT:C50620 INTRAUTERINE DEATH NCIT:C50620 IUD NCIT:C50620 Intrauterine fetal death NCIT:C50620 A disorder characterized by inhibition of fetal growth resulting in the inability of the fetus to achieve its potential weight OR A fetus that does not grow beyond the 10th percentile of conventionally accepted weight for gestational age. CCTO:000909 implies CCTO:000049 CCTO:000909 implies CCTO:001124 CCTO:000909(time_t t0) = EVENT_STATE(CCTO:000909, t0) NCI:CTCAE:10054746 NCIT:C114875 NCIT:C80083 UMLS:C0015934 Fetal SGA Fetal Small for Gestational Age Fetal growth restriction Fetus Small for Gestational Age IUGR Intrauterine growth restriction Intrauterine growth retardation cancer_care_treatment_outcome CCTO:000909 Fetal growth retardation CCTO:000909 A disorder characterized by inhibition of fetal growth resulting in the inability of the fetus to achieve its potential weight OR A fetus that does not grow beyond the 10th percentile of conventionally accepted weight for gestational age. NCI:CTCAE NCIT:C114875 Fetal SGA NCIT:C114875 Fetal Small for Gestational Age NCIT:C114875 Fetal growth restriction NCIT:C114875 Fetus Small for Gestational Age NCIT:C114875 IUGR NCIT:C114875 Intrauterine growth restriction NCIT:C114875 Intrauterine growth retardation NCIT:C114875 Intrauterine growth retardation NCIT:C80083 Birth when a fetus is less than 37 weeks and 0 days gestational age OR A disorder characterized by delivery of a viable infant before the normal end of gestation. Typically, viability is achievable between the twentieth and thirty-seventh week of gestation. CCTO:000910 implies CCTO:000049 CCTO:000910 implies CCTO:001124 CCTO:000910(time_t t0) = EVENT_STATE(CCTO:000910, t0) NCI:CTCAE:10036595 NCIT:C92861 UMLS:C0151526 Pre-term Preterm birth Preterm delivery cancer_care_treatment_outcome CCTO:000910 Premature delivery CCTO:000910 Birth when a fetus is less than 37 weeks and 0 days gestational age OR A disorder characterized by delivery of a viable infant before the normal end of gestation. Typically, viability is achievable between the twentieth and thirty-seventh week of gestation. NCI:CTCAE NCIT:C92861 Pre-term NCIT:C92861 Preterm birth NCIT:C92861 Preterm delivery NCIT:C92861 A pregnancy that was not desired or was timed incorrectly at the time that the conception occurred OR A disorder characterized by an unexpected pregnancy at the time of conception. CCTO:000911 implies CCTO:000049 CCTO:000911 implies CCTO:001124 CCTO:000911(time_t t0) = EVENT_STATE(CCTO:000911, t0) NCI:CTCAE:10045542 NCIT:C79801 UMLS:C0041747 cancer_care_treatment_outcome CCTO:000911 Unintended pregnancy CCTO:000911 A pregnancy that was not desired or was timed incorrectly at the time that the conception occurred OR A disorder characterized by an unexpected pregnancy at the time of conception. NCI:CTCAE NCIT:C79801 A disorder characterized by a state of restlessness associated with unpleasant feelings of irritability and tension OR A state of restlessness associated with unpleasant feelings of irritability and tension. Causes include pain, stress, fever, alcohol and nicotine withdrawal, cocaine and hallucinogenic drugs use, depression, bipolar disorders, and schizophrenia. CCTO:000912 implies CCTO:000049 CCTO:000912 implies CCTO:001105 CCTO:000912(time_t t0) = EVENT_STATE(CCTO:000912, t0) NCI:CTCAE:10001497 NCIT:C55435 NCIT:C79530 UMLS:C0085631 UMLS:C1963060 Agitation adverse event cancer_care_treatment_outcome CCTO:000912 Agitation CCTO:000912 A disorder characterized by a state of restlessness associated with unpleasant feelings of irritability and tension OR A state of restlessness associated with unpleasant feelings of irritability and tension. Causes include pain, stress, fever, alcohol and nicotine withdrawal, cocaine and hallucinogenic drugs use, depression, bipolar disorders, and schizophrenia. NCI:CTCAE NCIT:C79530 Agitation adverse event NCIT:C55435 Inability to achieve orgasm OR A disorder characterized by an inability to achieve orgasm. CCTO:000913 implies CCTO:000049 CCTO:000913 implies CCTO:001105 CCTO:000913(time_t t0) = EVENT_STATE(CCTO:000913, t0) NCI:CTCAE:10002652 NCIT:C78177 UMLS:C0234022 cancer_care_treatment_outcome CCTO:000913 Anorgasmia CCTO:000913 Inability to achieve orgasm OR A disorder characterized by an inability to achieve orgasm. NCI:CTCAE NCIT:C78177 A mental state characterized by a lack of clear and orderly thought and behavior OR A disorder characterized by a lack of clear and orderly thought and behavior. CCTO:000914 implies CCTO:000049 CCTO:000914 implies CCTO:001105 CCTO:000914(time_t t0) = EVENT_STATE(CCTO:000914, t0) NCI:CTCAE:10010300 NCIT:C37928 NCIT:C55379 UMLS:C0009676 UMLS:C0233407 UMLS:C1963086 Confusion adverse event Confusion/disorientation Disorientation Disorientation/confusion cancer_care_treatment_outcome CCTO:000914 Confusion CCTO:000914 A mental state characterized by a lack of clear and orderly thought and behavior OR A disorder characterized by a lack of clear and orderly thought and behavior. NCI:CTCAE NCIT:C37928 Confusion adverse event NCIT:C55379 Confusion/disorientation NCIT:C37928 Disorientation NCIT:C37928 Disorientation/confusion NCIT:C37928 A disorder characterized by sexual dysfunction characterized by a delay in climax OR Sexual dysfunction characterized by a delay in climax. CCTO:000915 implies CCTO:000049 CCTO:000915 implies CCTO:001105 CCTO:000915(time_t t0) = EVENT_STATE(CCTO:000915, t0) NCI:CTCAE:10057066 NCIT:C78252 UMLS:C1112573 cancer_care_treatment_outcome CCTO:000915 Delayed orgasm CCTO:000915 A disorder characterized by sexual dysfunction characterized by a delay in climax OR Sexual dysfunction characterized by a delay in climax. NCI:CTCAE NCIT:C78252 A disorder characterized by the acute and sudden development of confusion, illusions, movement changes, inattentiveness, agitation, and hallucinations. Usually, it is a reversible condition OR A usually reversible condition characterized by the acute and sudden development of confusion, illusions, movement changes, inattentiveness, agitation, and hallucinations. Causes include drug abuse, poisoning, infectious processes, and fluid and electrolyte imbalance. CCTO:000916 implies CCTO:000049 CCTO:000916 implies CCTO:001105 CCTO:000916(time_t t0) = EVENT_STATE(CCTO:000916, t0) NCI:CTCAE:10012218 NCIT:C2981 UMLS:C0011206 cancer_care_treatment_outcome CCTO:000916 Delirium CCTO:000916 A disorder characterized by the acute and sudden development of confusion, illusions, movement changes, inattentiveness, agitation, and hallucinations. Usually, it is a reversible condition OR A usually reversible condition characterized by the acute and sudden development of confusion, illusions, movement changes, inattentiveness, agitation, and hallucinations. Causes include drug abuse, poisoning, infectious processes, and fluid and electrolyte imbalance. NCI:CTCAE NCIT:C2981 A disorder characterized by false personal beliefs held contrary to reality, despite contradictory evidence and common sense OR False personal beliefs held contrary to reality, despite contradictory evidence and common sense. CCTO:000917 implies CCTO:000049 CCTO:000917 implies CCTO:001105 CCTO:000917(time_t t0) = EVENT_STATE(CCTO:000917, t0) NCI:CTCAE:10012260 NCIT:C26741 UMLS:C0011253 Delusion cancer_care_treatment_outcome CCTO:000917 Delusions CCTO:000917 A disorder characterized by false personal beliefs held contrary to reality, despite contradictory evidence and common sense OR False personal beliefs held contrary to reality, despite contradictory evidence and common sense. NCI:CTCAE NCIT:C26741 Delusion NCIT:C26741 An exaggerated feeling of well-being which is disproportionate to events and stimuli. It may result from psychological causes, organic brain syndromes, or toxic states OR A disorder characterized by an exaggerated feeling of well-being which is disproportionate to events and stimuli. CCTO:000918 implies CCTO:000049 CCTO:000918 implies CCTO:001105 CCTO:000918(time_t t0) = EVENT_STATE(CCTO:000918, t0) NCI:CTCAE:10015533 NCIT:C34598 NCIT:C55453 UMLS:C0235146 UMLS:C1963107 Euphoria adverse event cancer_care_treatment_outcome CCTO:000918 Euphoria CCTO:000918 An exaggerated feeling of well-being which is disproportionate to events and stimuli. It may result from psychological causes, organic brain syndromes, or toxic states OR A disorder characterized by an exaggerated feeling of well-being which is disproportionate to events and stimuli. NCI:CTCAE NCIT:C34598 Euphoria adverse event NCIT:C55453 A false sensory perception in the absence of an external stimulus, as distinct from an illusion which is a misperception of an external stimulus OR A disorder characterized by a false sensory perception in the absence of an external stimulus. CCTO:000919 implies CCTO:000049 CCTO:000919 implies CCTO:001105 CCTO:000919(time_t t0) = EVENT_STATE(CCTO:000919, t0) NCI:CTCAE:10019077 NCIT:C37961 UMLS:C0018524 Hallucination cancer_care_treatment_outcome CCTO:000919 Hallucinations CCTO:000919 A false sensory perception in the absence of an external stimulus, as distinct from an illusion which is a misperception of an external stimulus OR A disorder characterized by a false sensory perception in the absence of an external stimulus. NCI:CTCAE NCIT:C37961 Hallucination NCIT:C37961 A disorder characterized by difficulty in falling asleep and/or remaining asleep OR A sleep disorder characterized by difficulty in falling asleep and/or remaining asleep OR A question about an individual's sleep quality. CCTO:000920 implies CCTO:000049 CCTO:000920 implies CCTO:001105 CCTO:000920(time_t t0) = EVENT_STATE(CCTO:000920, t0) NCI:CTCAE:10022437 NCIT:C121705 NCIT:C28286 NCIT:C55333 UMLS:C0424563 UMLS:C0917801 UMLS:C1963237 Insomnia adverse event Insomnia distress My sleep quality was Sleep quality cancer_care_treatment_outcome CCTO:000920 Insomnia CCTO:000920 A disorder characterized by difficulty in falling asleep and/or remaining asleep OR A sleep disorder characterized by difficulty in falling asleep and/or remaining asleep OR A question about an individual's sleep quality. NCI:CTCAE NCIT:C121705 NCIT:C28286 Insomnia adverse event NCIT:C55333 Insomnia distress NCIT:C121705 My sleep quality was NCIT:C121705 Sleep quality NCIT:C121705 Decreased sexual desire OR A disorder characterized by a decrease in sexual desire. CCTO:000921 implies CCTO:000049 CCTO:000921 implies CCTO:001105 CCTO:000921(time_t t0) = EVENT_STATE(CCTO:000921, t0) NCI:CTCAE:10024419 NCIT:C78432 UMLS:C0011124 Decreased libido cancer_care_treatment_outcome CCTO:000921 Libido decreased CCTO:000921 Decreased sexual desire OR A disorder characterized by a decrease in sexual desire. NCI:CTCAE NCIT:C78432 Decreased libido NCIT:C78432 A disorder characterized by an increase in sexual desire OR Increased sexual desire. CCTO:000922 implies CCTO:000049 CCTO:000922 implies CCTO:001105 CCTO:000922(time_t t0) = EVENT_STATE(CCTO:000922, t0) NCI:CTCAE:10024421 NCIT:C78433 UMLS:C0021177 Increased libido cancer_care_treatment_outcome CCTO:000922 Libido increased CCTO:000922 A disorder characterized by an increase in sexual desire OR Increased sexual desire. NCI:CTCAE NCIT:C78433 Increased libido NCIT:C78433 Excitement of psychotic proportions manifested by mental and physical hyperactivity, disorganisation of behaviour and elevation of mood OR A disorder characterized by excitement of psychotic proportions manifested by mental and physical hyperactivity, disorganization of behavior and elevation of mood. CCTO:000923 implies CCTO:000049 CCTO:000923 implies CCTO:001105 CCTO:000923(time_t t0) = EVENT_STATE(CCTO:000923, t0) NCI:CTCAE:10026749 NCIT:C61374 UMLS:C0338831 Manic Manic state cancer_care_treatment_outcome CCTO:000923 Mania CCTO:000923 Excitement of psychotic proportions manifested by mental and physical hyperactivity, disorganisation of behaviour and elevation of mood OR A disorder characterized by excitement of psychotic proportions manifested by mental and physical hyperactivity, disorganization of behavior and elevation of mood. NCI:CTCAE NCIT:C61374 Manic NCIT:C61374 Manic state NCIT:C61374 A noticeable change in a person's behavior and thinking. Causes include depression, drug or alcohol abuse, brain injuries, brain tumors, and Alzheimer's disease OR A disorder characterized by a conspicuous change in a person's behavior and thinking. CCTO:000924 implies CCTO:000049 CCTO:000924 implies CCTO:001105 CCTO:000924(time_t t0) = EVENT_STATE(CCTO:000924, t0) NCI:CTCAE:10034719 NCIT:C78548 UMLS:C0240735 cancer_care_treatment_outcome CCTO:000924 Personality change CCTO:000924 A noticeable change in a person's behavior and thinking. Causes include depression, drug or alcohol abuse, brain injuries, brain tumors, and Alzheimer's disease OR A disorder characterized by a conspicuous change in a person's behavior and thinking. NCI:CTCAE NCIT:C78548 A disorder characterized by personality change, impaired functioning, and loss of touch with reality. It may be a manifestation of schizophrenia, bipolar disorder or brain tumor OR A mental disorder characterized by personality change, impaired functioning, and loss of touch with reality. CCTO:000925 implies CCTO:000049 CCTO:000925 implies CCTO:001105 CCTO:000925(time_t t0) = EVENT_STATE(CCTO:000925, t0) NCI:CTCAE:10037234 NCIT:C78576 UMLS:C0033975 cancer_care_treatment_outcome CCTO:000925 Psychosis CCTO:000925 A disorder characterized by personality change, impaired functioning, and loss of touch with reality. It may be a manifestation of schizophrenia, bipolar disorder or brain tumor OR A mental disorder characterized by personality change, impaired functioning, and loss of touch with reality. NCI:CTCAE NCIT:C78576 A disorder characterized by an inability to rest, relax or be still OR An inability to rest, relax, or be still. CCTO:000926 implies CCTO:000049 CCTO:000926 implies CCTO:001105 CCTO:000926(time_t t0) = EVENT_STATE(CCTO:000926, t0) NCI:CTCAE:10038743 NCIT:C74533 UMLS:C0085631 Feeling of Restlessness Restless cancer_care_treatment_outcome CCTO:000926 Restlessness CCTO:000926 A disorder characterized by an inability to rest, relax or be still OR An inability to rest, relax, or be still. NCI:CTCAE NCIT:C74533 Feeling of Restlessness NCIT:C74533 Restless NCIT:C74533 Thoughts of taking one's own life OR A disorder characterized by thoughts of taking one's own life. CCTO:000927 implies CCTO:000049 CCTO:000927 implies CCTO:001105 CCTO:000927(time_t t0) = EVENT_STATE(CCTO:000927, t0) NCI:CTCAE:10042458 NCIT:C80102 UMLS:C0424000 cancer_care_treatment_outcome CCTO:000927 Suicidal ideation CCTO:000927 Thoughts of taking one's own life OR A disorder characterized by thoughts of taking one's own life. NCI:CTCAE NCIT:C80102 A disorder characterized by self-inflicted harm in an attempt to end one's own life OR Self-inflicted harm in an attempt to end one's own life. CCTO:000928 implies CCTO:000049 CCTO:000928 implies CCTO:001105 CCTO:000928(time_t t0) = EVENT_STATE(CCTO:000928, t0) NCI:CTCAE:10042464 NCIT:C80111 UMLS:C0038663 UMLS:C1547270 cancer_care_treatment_outcome CCTO:000928 Suicide attempt CCTO:000928 A disorder characterized by self-inflicted harm in an attempt to end one's own life OR Self-inflicted harm in an attempt to end one's own life. NCI:CTCAE NCIT:C80111 Sudden and sustained deterioration of the kidney function characterized by decreased glomerular filtration rate, increased serum creatinine or oliguria OR A disorder characterized by the acute loss of renal function and is traditionally classified as pre-renal (low blood flow into kidney), renal (kidney damage) and post-renal causes (ureteral or bladder outflow obstruction). CCTO:000929 implies CCTO:000049 CCTO:000929 implies CCTO:001125 CCTO:000929(time_t t0) = EVENT_STATE(CCTO:000929, t0) NCI:CTCAE:10069339 NCIT:C26808 NCIT:C80075 UMLS:C0022660 UMLS:C0264490 UMLS:C1705280 UMLS:C2609414 AKI ARF Acute renal failure cancer_care_treatment_outcome CCTO:000929 Acute kidney injury CCTO:000929 Sudden and sustained deterioration of the kidney function characterized by decreased glomerular filtration rate, increased serum creatinine or oliguria OR A disorder characterized by the acute loss of renal function and is traditionally classified as pre-renal (low blood flow into kidney), renal (kidney damage) and post-renal causes (ureteral or bladder outflow obstruction). NCI:CTCAE NCIT:C26808 AKI NCIT:C26808 ARF NCIT:C26808 Acute renal failure NCIT:C26808 A disorder characterized by a rupture in the bladder wall OR A rupture in the bladder wall due to traumatic or pathologic processes. CCTO:000930 implies CCTO:000049 CCTO:000930 implies CCTO:001125 CCTO:000930(time_t t0) = EVENT_STATE(CCTO:000930, t0) NCI:CTCAE:10063575 NCIT:C56756 NCIT:C78208 UMLS:C0434133 UMLS:C1963201 Bladder perforation adverse event cancer_care_treatment_outcome CCTO:000930 Bladder perforation CCTO:000930 A disorder characterized by a rupture in the bladder wall OR A rupture in the bladder wall due to traumatic or pathologic processes. NCI:CTCAE NCIT:C78208 Bladder perforation adverse event NCIT:C56756 A disorder characterized by a sudden and involuntary contraction of the bladder wall OR A sudden and involuntary contraction of the bladder wall. CCTO:000931 implies CCTO:000049 CCTO:000931 implies CCTO:001125 CCTO:000931(time_t t0) = EVENT_STATE(CCTO:000931, t0) NCI:CTCAE:10048994 NCIT:C78210 UMLS:C0426390 cancer_care_treatment_outcome CCTO:000931 Bladder spasm CCTO:000931 A disorder characterized by a sudden and involuntary contraction of the bladder wall OR A sudden and involuntary contraction of the bladder wall. NCI:CTCAE NCIT:C78210 Impairment of the renal function secondary to chronic kidney damage persisting for three or more months OR A disorder characterized by gradual and usually permanent loss of kidney function resulting in renal failure. CCTO:000932 implies CCTO:000049 CCTO:000932 implies CCTO:001125 CCTO:000932(time_t t0) = EVENT_STATE(CCTO:000932, t0) NCI:CTCAE:10064848 NCIT:C80078 UMLS:C0022661 UMLS:C0403447 UMLS:C1561643 CKD - Chronic Kidney Disease Chronic renal disease Chronic renal failure Chronic renal insufficiency cancer_care_treatment_outcome CCTO:000932 Chronic kidney disease CCTO:000932 Impairment of the renal function secondary to chronic kidney damage persisting for three or more months OR A disorder characterized by gradual and usually permanent loss of kidney function resulting in renal failure. NCI:CTCAE NCIT:C80078 CKD - Chronic Kidney Disease NCIT:C80078 Chronic renal disease NCIT:C80078 Chronic renal failure NCIT:C80078 Chronic renal insufficiency NCIT:C80078 A disorder characterized by inflammation of the bladder which is not caused by an infection of the urinary tract OR An inflammation of the bladder which is not caused by an infection of the urinary tract. Representative examples include interstitial cystitis and radiation-induced cystitis. CCTO:000933 implies CCTO:000049 CCTO:000933 implies CCTO:001125 CCTO:000933(time_t t0) = EVENT_STATE(CCTO:000933, t0) NCI:CTCAE:10063057 NCIT:C78250 UMLS:C0403632 Non-infectious cystitis cancer_care_treatment_outcome CCTO:000933 Cystitis noninfective CCTO:000933 A disorder characterized by inflammation of the bladder which is not caused by an infection of the urinary tract OR An inflammation of the bladder which is not caused by an infection of the urinary tract. Representative examples include interstitial cystitis and radiation-induced cystitis. NCI:CTCAE NCIT:C78250 Non-infectious cystitis NCIT:C78250 A disorder characterized by laboratory test results that indicate blood in the urine OR Blood in the urine. CCTO:000934 implies CCTO:000049 CCTO:000934 implies CCTO:001125 CCTO:000934(time_t t0) = EVENT_STATE(CCTO:000934, t0) NCI:CTCAE:10019450 NCIT:C3090 UMLS:C0018965 cancer_care_treatment_outcome CCTO:000934 Hematuria CCTO:000934 A disorder characterized by laboratory test results that indicate blood in the urine OR Blood in the urine. NCI:CTCAE NCIT:C3090 A disorder characterized by laboratory test results that indicate the presence of free hemoglobin in the urine OR A laboratory test result which indicates free hemoglobin in the urine. CCTO:000935 implies CCTO:000049 CCTO:000935 implies CCTO:001125 CCTO:000935(time_t t0) = EVENT_STATE(CCTO:000935, t0) NCI:CTCAE:10019489 NCIT:C34677 NCIT:C55177 UMLS:C0019048 UMLS:C1963124 Hemoglobinuria adverse event cancer_care_treatment_outcome CCTO:000935 Hemoglobinuria CCTO:000935 A disorder characterized by laboratory test results that indicate the presence of free hemoglobin in the urine OR A laboratory test result which indicates free hemoglobin in the urine. NCI:CTCAE NCIT:C34677 Hemoglobinuria adverse event NCIT:C55177 The presence of abnormal amounts of protein in the urine. CCTO:000936 implies CCTO:000049 CCTO:000936 implies CCTO:001125 CCTO:000936(time_t t0) = EVENT_STATE(CCTO:000936, t0) NCI:CTCAE:10037032 NCIT:C38012 NCIT:C55219 UMLS:C0033687 UMLS:C1962972 Proteinuria adverse event cancer_care_treatment_outcome CCTO:000936 Proteinuria CCTO:000936 The presence of abnormal amounts of protein in the urine. NCIT:C38012 Proteinuria adverse event NCIT:C55219 A disorder characterized by the formation of crystals in the pelvis of the kidney OR The presence of a calculus in the pelvis of the kidney; this is most often composed of mineral salts and proteins OR Crystals in the pelvis of the kidney. CCTO:000937 implies CCTO:000049 CCTO:000937 implies CCTO:001125 CCTO:000937(time_t t0) = EVENT_STATE(CCTO:000937, t0) NCI:CTCAE:10038385 NCIT:C114667 NCIT:C26807 UMLS:C0022650 UMLS:C0392525 Kidney calculus Kidney stone Nephrolithiasis Renal calculus Renal stone cancer_care_treatment_outcome CCTO:000937 Renal calculi CCTO:000937 A disorder characterized by the formation of crystals in the pelvis of the kidney OR The presence of a calculus in the pelvis of the kidney; this is most often composed of mineral salts and proteins OR Crystals in the pelvis of the kidney. NCI:CTCAE NCIT:C114667 NCIT:C26807 Kidney calculus NCIT:C26807 Kidney stone NCIT:C114667 Kidney stone NCIT:C26807 Nephrolithiasis NCIT:C114667 Renal calculus NCIT:C26807 Renal stone NCIT:C26807 A disorder characterized by paroxysmal and severe flank marked discomfort radiating to the inguinal area. Often, the cause is the passage of kidney stones OR Paroxysmal and severe flank pain radiating to the inguinal area. It is caused by the passage of a kidney stone through the ureter. CCTO:000938 implies CCTO:000049 CCTO:000938 implies CCTO:001125 CCTO:000938(time_t t0) = EVENT_STATE(CCTO:000938, t0) NCI:CTCAE:10038419 NCIT:C78593 UMLS:C0152169 cancer_care_treatment_outcome CCTO:000938 Renal colic CCTO:000938 A disorder characterized by paroxysmal and severe flank marked discomfort radiating to the inguinal area. Often, the cause is the passage of kidney stones OR Paroxysmal and severe flank pain radiating to the inguinal area. It is caused by the passage of a kidney stone through the ureter. NCI:CTCAE NCIT:C78593 Bleeding originating from the kidney OR A disorder characterized by bleeding from the kidney. CCTO:000939 implies CCTO:000049 CCTO:000939 implies CCTO:001125 CCTO:000939(time_t t0) = EVENT_STATE(CCTO:000939, t0) NCI:CTCAE:10038463 NCIT:C78594 UMLS:C0392175 cancer_care_treatment_outcome CCTO:000939 Renal hemorrhage CCTO:000939 Bleeding originating from the kidney OR A disorder characterized by bleeding from the kidney. NCI:CTCAE NCIT:C78594 A disorder characterized by an abnormal communication between any part of the urinary system and another organ or anatomic site OR An abnormal communication between any part of the urinary system and another organ or cavity. CCTO:000940 implies CCTO:000049 CCTO:000940 implies CCTO:001125 CCTO:000940(time_t t0) = EVENT_STATE(CCTO:000940, t0) NCI:CTCAE:10065368 NCIT:C79850 UMLS:C0042021 Urinary tract fistula cancer_care_treatment_outcome CCTO:000940 Urinary fistula CCTO:000940 A disorder characterized by an abnormal communication between any part of the urinary system and another organ or anatomic site OR An abnormal communication between any part of the urinary system and another organ or cavity. NCI:CTCAE NCIT:C79850 Urinary tract fistula NCIT:C79850 Urination at short intervals; it may result from increased urine formation, decreased bladder capacity, or lower urinary tract irritation OR A disorder characterized by urination at short intervals. CCTO:000941 implies CCTO:000049 CCTO:000941 implies CCTO:001125 CCTO:000941(time_t t0) = EVENT_STATE(CCTO:000941, t0) NCI:CTCAE:10046539 NCIT:C26906 UMLS:C0042023 Frequency, urinary cancer_care_treatment_outcome CCTO:000941 Urinary frequency CCTO:000941 Urination at short intervals; it may result from increased urine formation, decreased bladder capacity, or lower urinary tract irritation OR A disorder characterized by urination at short intervals. NCI:CTCAE NCIT:C26906 Frequency, urinary NCIT:C26906 A disorder characterized by inability to control the flow of urine from the bladder OR Involuntary passage of urine outside the body. CCTO:000942 implies CCTO:000049 CCTO:000942 implies CCTO:001125 CCTO:000942(time_t t0) = EVENT_STATE(CCTO:000942, t0) NCI:CTCAE:10046543 NCIT:C78497 UMLS:C0014394 UMLS:C0042024 UMLS:C0270327 Enuresis cancer_care_treatment_outcome CCTO:000942 Urinary incontinence CCTO:000942 A disorder characterized by inability to control the flow of urine from the bladder OR Involuntary passage of urine outside the body. NCI:CTCAE NCIT:C78497 Enuresis NCIT:C78497 A disorder characterized by accumulation of urine within the bladder because of the inability to urinate OR Accumulation of urine within the bladder because of the inability to urinate. CCTO:000943 implies CCTO:000049 CCTO:000943 implies CCTO:001125 CCTO:000943(time_t t0) = EVENT_STATE(CCTO:000943, t0) NCI:CTCAE:10046555 NCIT:C50790 UMLS:C0005687 UMLS:C0080274 Bladder distention Retention, urinary Urine retention cancer_care_treatment_outcome CCTO:000943 Urinary retention CCTO:000943 A disorder characterized by accumulation of urine within the bladder because of the inability to urinate OR Accumulation of urine within the bladder because of the inability to urinate. NCI:CTCAE NCIT:C50790 Bladder distention NCIT:C50790 Retention, urinary NCIT:C50790 Urine retention NCIT:C50790 A disorder characterized by blockage of the normal flow of contents of the urinary tract OR Blockage of the normal flow of contents of the urinary tract. CCTO:000944 implies CCTO:000049 CCTO:000944 implies CCTO:001125 CCTO:000944(time_t t0) = EVENT_STATE(CCTO:000944, t0) NCI:CTCAE:10061574 NCIT:C79805 UMLS:C0178879 cancer_care_treatment_outcome CCTO:000944 Urinary tract obstruction CCTO:000944 A disorder characterized by blockage of the normal flow of contents of the urinary tract OR Blockage of the normal flow of contents of the urinary tract. NCI:CTCAE NCIT:C79805 Painful sensation in any part of the urinary tract OR A disorder characterized by a sensation of marked discomfort in the urinary tract. CCTO:000945 implies CCTO:000107 CCTO:000945 implies CCTO:001125 CCTO:000945(time_t t0) = EVENT_STATE(CCTO:000945, t0) NCI:CTCAE:10062225 NCIT:C83493 UMLS:C0423701 cancer_care_treatment_outcome CCTO:000945 Urinary tract pain CCTO:000945 Painful sensation in any part of the urinary tract OR A disorder characterized by a sensation of marked discomfort in the urinary tract. NCI:CTCAE NCIT:C83493 An acute and compelling urge to urinate OR A disorder characterized by a sudden compelling urge to urinate. CCTO:000946 implies CCTO:000049 CCTO:000946 implies CCTO:001125 CCTO:000946(time_t t0) = EVENT_STATE(CCTO:000946, t0) NCI:CTCAE:10046593 NCIT:C50792 UMLS:C0085606 Micturation urgency cancer_care_treatment_outcome CCTO:000946 Urinary urgency CCTO:000946 An acute and compelling urge to urinate OR A disorder characterized by a sudden compelling urge to urinate. NCI:CTCAE NCIT:C50792 Micturation urgency NCIT:C50792 A disorder characterized by a change in the color of the urine OR Change in the color of the urine. Causes include medications, vitamins, urinary tract infection, liver disease, hemolysis, and kidney cancer. CCTO:000947 implies CCTO:000049 CCTO:000947 implies CCTO:001125 CCTO:000947(time_t t0) = EVENT_STATE(CCTO:000947, t0) NCI:CTCAE:10046628 NCIT:C78678 UMLS:C0522153 cancer_care_treatment_outcome CCTO:000947 Urine discoloration CCTO:000947 A disorder characterized by a change in the color of the urine OR Change in the color of the urine. Causes include medications, vitamins, urinary tract infection, liver disease, hemolysis, and kidney cancer. NCI:CTCAE NCIT:C78678 A disorder characterized by laboratory test results that indicate complete absence of spermatozoa in the semen OR Complete absence of spermatozoa in the semen. CCTO:000948 implies CCTO:000049 CCTO:000948 implies CCTO:001126 CCTO:000948(time_t t0) = EVENT_STATE(CCTO:000948, t0) NCI:CTCAE:10003883 NCIT:C80076 UMLS:C0004509 UMLS:C1704202 Aspermia cancer_care_treatment_outcome CCTO:000948 Azoospermia CCTO:000948 A disorder characterized by laboratory test results that indicate complete absence of spermatozoa in the semen OR Complete absence of spermatozoa in the semen. NCI:CTCAE NCIT:C80076 Aspermia NCIT:C80076 Involution of the breast parenchyma OR A disorder characterized by underdevelopment of the breast. CCTO:000949 implies CCTO:000049 CCTO:000949 implies CCTO:001126 CCTO:000949(time_t t0) = EVENT_STATE(CCTO:000949, t0) NCI:CTCAE:10006179 NCIT:C83494 UMLS:C0151511 cancer_care_treatment_outcome CCTO:000949 Breast atrophy CCTO:000949 Involution of the breast parenchyma OR A disorder characterized by underdevelopment of the breast. NCI:CTCAE NCIT:C83494 A disorder characterized by marked discomfort sensation in the breast region OR Painful sensation in the breast region. CCTO:000950 implies CCTO:000107 CCTO:000950 implies CCTO:001126 CCTO:000950(time_t t0) = EVENT_STATE(CCTO:000950, t0) NCI:CTCAE:10006298 NCIT:C56025 NCIT:C78223 UMLS:C0024902 UMLS:C1963166 Breast pain adverse event cancer_care_treatment_outcome CCTO:000950 Breast pain CCTO:000950 A disorder characterized by marked discomfort sensation in the breast region OR Painful sensation in the breast region. NCI:CTCAE NCIT:C78223 Breast pain adverse event NCIT:C56025 Abnormally painful abdominal cramps during menstruation OR A disorder characterized by abnormally painful abdominal cramps during menses. CCTO:000951 implies CCTO:000049 CCTO:000951 implies CCTO:001126 CCTO:000951(time_t t0) = EVENT_STATE(CCTO:000951, t0) NCI:CTCAE:10013934 NCIT:C34559 UMLS:C0013390 cancer_care_treatment_outcome CCTO:000951 Dysmenorrhea CCTO:000951 Abnormally painful abdominal cramps during menstruation OR A disorder characterized by abnormally painful abdominal cramps during menses. NCI:CTCAE NCIT:C34559 A disorder characterized by painful or difficult coitus OR Painful or difficult coitus. CCTO:000952 implies CCTO:000049 CCTO:000952 implies CCTO:001126 CCTO:000952(time_t t0) = EVENT_STATE(CCTO:000952, t0) NCI:CTCAE:10013941 NCIT:C2997 UMLS:C0013394 UMLS:C1384606 cancer_care_treatment_outcome CCTO:000952 Dyspareunia CCTO:000952 A disorder characterized by painful or difficult coitus OR Painful or difficult coitus. NCI:CTCAE NCIT:C2997 A disorder characterized by problems related to ejaculation. This category includes premature, delayed, retrograde and painful ejaculation OR A disorder referring to problems related to ejaculation. This category includes premature, delayed, retrograde, and painful ejaculation. CCTO:000953 implies CCTO:000049 CCTO:000953 implies CCTO:001126 CCTO:000953(time_t t0) = EVENT_STATE(CCTO:000953, t0) NCI:CTCAE:10014326 NCIT:C78264 UMLS:C0235969 UMLS:C1558165 Ejaculation dysfunction Ejaculatory dysfunction cancer_care_treatment_outcome CCTO:000953 Ejaculation disorder CCTO:000953 A disorder characterized by problems related to ejaculation. This category includes premature, delayed, retrograde and painful ejaculation OR A disorder referring to problems related to ejaculation. This category includes premature, delayed, retrograde, and painful ejaculation. NCI:CTCAE NCIT:C78264 Ejaculation dysfunction NCIT:C78264 Ejaculatory dysfunction NCIT:C78264 A disorder characterized by the persistent or recurrent inability to achieve or to maintain an erection during sexual activity OR A disorder characterized by the persistent or recurrent inability to achieve or to maintain an erection during sexual activity OR Persistent or recurrent inability to achieve or to maintain an erection during sexual activity. CCTO:000954 implies CCTO:000049 CCTO:000954 implies CCTO:001126 CCTO:000954(time_t t0) = EVENT_STATE(CCTO:000954, t0) NCI:CTCAE:10061461 NCIT:C3133 NCIT:C34801 NCIT:C55615 UMLS:C0242350 UMLS:C1961100 Erectile dysfunction adverse event Impotence Impotent Male erectile disorder cancer_care_treatment_outcome CCTO:000954 Erectile dysfunction CCTO:000954 A disorder characterized by the persistent or recurrent inability to achieve or to maintain an erection during sexual activity OR A disorder characterized by the persistent or recurrent inability to achieve or to maintain an erection during sexual activity OR Persistent or recurrent inability to achieve or to maintain an erection during sexual activity. NCI:CTCAE NCIT:C3133 NCIT:C34801 Erectile dysfunction adverse event NCIT:C55615 Impotence NCIT:C3133 Impotent NCIT:C3133 Male erectile disorder NCIT:C34801 A disorder characterized by blockage of the normal flow of the contents in the fallopian tube OR Blockage of the normal flow of the contents in the fallopian tube. CCTO:000955 implies CCTO:000049 CCTO:000955 implies CCTO:001126 CCTO:000955(time_t t0) = EVENT_STATE(CCTO:000955, t0) NCI:CTCAE:10065789 NCIT:C57059 NCIT:C78293 UMLS:C0041274 UMLS:C1963253 Fallopian tube obstruction adverse event cancer_care_treatment_outcome CCTO:000955 Fallopian tube obstruction CCTO:000955 A disorder characterized by blockage of the normal flow of the contents in the fallopian tube OR Blockage of the normal flow of the contents in the fallopian tube. NCI:CTCAE NCIT:C78293 Fallopian tube obstruction adverse event NCIT:C57059 A disorder characterized by a narrowing of the fallopian tube lumen OR Narrowing of the lumen of the fallopian tube. CCTO:000956 implies CCTO:000049 CCTO:000956 implies CCTO:001126 CCTO:000956(time_t t0) = EVENT_STATE(CCTO:000956, t0) NCI:CTCAE:10065791 NCIT:C78295 UMLS:C0459524 cancer_care_treatment_outcome CCTO:000956 Fallopian tube stenosis CCTO:000956 A disorder characterized by a narrowing of the fallopian tube lumen OR Narrowing of the lumen of the fallopian tube. NCI:CTCAE NCIT:C78295 A disorder characterized by an abnormal communication between a female reproductive system organ and another organ or anatomic site OR An abnormal communication between a female reproductive system organ and another organ or cavity. CCTO:000957 implies CCTO:000049 CCTO:000957 implies CCTO:001126 CCTO:000957(time_t t0) = EVENT_STATE(CCTO:000957, t0) NCI:CTCAE:10061149 NCIT:C78298 UMLS:C0269131 cancer_care_treatment_outcome CCTO:000957 Female genital tract fistula CCTO:000957 A disorder characterized by an abnormal communication between a female reproductive system organ and another organ or anatomic site OR An abnormal communication between a female reproductive system organ and another organ or cavity. NCI:CTCAE NCIT:C78298 The development of secondary female sex characteristics in males due to extrinsic factors OR A disorder characterized by the development of secondary female sex characteristics in males due to extrinsic factors. CCTO:000958 implies CCTO:000049 CCTO:000958 implies CCTO:001126 CCTO:000958(time_t t0) = EVENT_STATE(CCTO:000958, t0) NCI:CTCAE:10054382 NCIT:C78299 UMLS:C0877195 Acquired feminization cancer_care_treatment_outcome CCTO:000958 Feminization acquired CCTO:000958 The development of secondary female sex characteristics in males due to extrinsic factors OR A disorder characterized by the development of secondary female sex characteristics in males due to extrinsic factors. NCI:CTCAE NCIT:C78299 Acquired feminization NCIT:C78299 A disorder characterized by swelling due to an excessive accumulation of fluid in the genitals OR Swelling due to an excessive accumulation of fluid in the genitals. CCTO:000959 implies CCTO:000226 CCTO:000959 implies CCTO:001126 CCTO:000959(time_t t0) = EVENT_STATE(CCTO:000959, t0) NCI:CTCAE:10018146 NCIT:C78324 UMLS:C0151604 cancer_care_treatment_outcome CCTO:000959 Genital edema CCTO:000959 A disorder characterized by swelling due to an excessive accumulation of fluid in the genitals OR Swelling due to an excessive accumulation of fluid in the genitals. NCI:CTCAE NCIT:C78324 A disorder characterized by excessive development of the breasts in males OR Development of breast tissue in males. CCTO:000960 implies CCTO:000049 CCTO:000960 implies CCTO:001126 CCTO:000960(time_t t0) = EVENT_STATE(CCTO:000960, t0) NCI:CTCAE:10018801 NCIT:C3073 NCIT:C55619 UMLS:C0018418 UMLS:C1963120 Gynecomastia adverse event cancer_care_treatment_outcome CCTO:000960 Gynecomastia CCTO:000960 A disorder characterized by excessive development of the breasts in males OR Development of breast tissue in males. NCI:CTCAE NCIT:C3073 Gynecomastia adverse event NCIT:C55619 The presence of blood in a fallopian tube OR A disorder characterized by the presence of blood in a fallopian tube. CCTO:000961 implies CCTO:000049 CCTO:000961 implies CCTO:001126 CCTO:000961(time_t t0) = EVENT_STATE(CCTO:000961, t0) NCI:CTCAE:10060602 NCIT:C78332 UMLS:C0018962 cancer_care_treatment_outcome CCTO:000961 Hematosalpinx CCTO:000961 The presence of blood in a fallopian tube OR A disorder characterized by the presence of blood in a fallopian tube. NCI:CTCAE NCIT:C78332 Deviations from the normal process; e.g. delayed, difficult, profuse, scanty, unusual bleeding, etc OR A disorder characterized by irregular cycle or duration of menses. CCTO:000962 implies CCTO:000049 CCTO:000962 implies CCTO:001126 CCTO:000962(time_t t0) = EVENT_STATE(CCTO:000962, t0) NCI:CTCAE:10022992 NCIT:C35219 UMLS:C0156404 Irregularities, menstrual Menstrual irregularities cancer_care_treatment_outcome CCTO:000962 Irregular menstruation CCTO:000962 Deviations from the normal process; e.g. delayed, difficult, profuse, scanty, unusual bleeding, etc OR A disorder characterized by irregular cycle or duration of menses. NCI:CTCAE NCIT:C35219 Irregularities, menstrual NCIT:C35219 Menstrual irregularities NCIT:C35219 A disorder not necessarily related to pregnancy that is observed in females and males. It is characterized by disturbances of milk secretion. Causes include damage to the breast parenchyma due to inflammation, medications, pituitary tumors, and hypothyroidism OR A disorder characterized by disturbances of milk secretion. It is not necessarily related to pregnancy that is observed in females and can be observed in males. CCTO:000963 implies CCTO:000049 CCTO:000963 implies CCTO:001126 CCTO:000963(time_t t0) = EVENT_STATE(CCTO:000963, t0) NCI:CTCAE:10061261 NCIT:C79606 UMLS:C0022927 cancer_care_treatment_outcome CCTO:000963 Lactation disorder CCTO:000963 A disorder not necessarily related to pregnancy that is observed in females and males. It is characterized by disturbances of milk secretion. Causes include damage to the breast parenchyma due to inflammation, medications, pituitary tumors, and hypothyroidism OR A disorder characterized by disturbances of milk secretion. It is not necessarily related to pregnancy that is observed in females and can be observed in males. NCI:CTCAE NCIT:C79606 Heavy bleeding during regular menstruation OR A disorder characterized by abnormally heavy vaginal bleeding during menses. CCTO:000964 implies CCTO:000049 CCTO:000964 implies CCTO:001126 CCTO:000964(time_t t0) = EVENT_STATE(CCTO:000964, t0) NCI:CTCAE:10027313 NCIT:C26829 UMLS:C0025323 cancer_care_treatment_outcome CCTO:000964 Menorrhagia CCTO:000964 Heavy bleeding during regular menstruation OR A disorder characterized by abnormally heavy vaginal bleeding during menses. NCI:CTCAE NCIT:C26829 A disorder characterized by a malformation of the nipple OR A congenital or acquired deformity of the nipple. CCTO:000965 implies CCTO:000049 CCTO:000965 implies CCTO:001126 CCTO:000965(time_t t0) = EVENT_STATE(CCTO:000965, t0) NCI:CTCAE:10065823 NCIT:C78503 UMLS:C0342102 cancer_care_treatment_outcome CCTO:000965 Nipple deformity CCTO:000965 A disorder characterized by a malformation of the nipple OR A congenital or acquired deformity of the nipple. NCI:CTCAE NCIT:C78503 Decreased number of spermatozoa in the semen OR A disorder characterized by a decrease in the number of spermatozoa in the semen. CCTO:000966 implies CCTO:000049 CCTO:000966 implies CCTO:001126 CCTO:000966(time_t t0) = EVENT_STATE(CCTO:000966, t0) NCI:CTCAE:10030300 NCIT:C34860 UMLS:C0028960 Low sperm count cancer_care_treatment_outcome CCTO:000966 Oligospermia CCTO:000966 Decreased number of spermatozoa in the semen OR A disorder characterized by a decrease in the number of spermatozoa in the semen. NCI:CTCAE NCIT:C34860 Low sperm count NCIT:C34860 A disorder characterized by bleeding from the ovary OR Bleeding originating from the ovary. CCTO:000967 implies CCTO:000049 CCTO:000967 implies CCTO:001126 CCTO:000967(time_t t0) = EVENT_STATE(CCTO:000967, t0) NCI:CTCAE:10065763 NCIT:C78511 UMLS:C1696704 cancer_care_treatment_outcome CCTO:000967 Ovarian hemorrhage CCTO:000967 A disorder characterized by bleeding from the ovary OR Bleeding originating from the ovary. NCI:CTCAE NCIT:C78511 Tearing or disruption of the ovarian tissue OR A disorder characterized by tearing or disruption of the ovarian tissue. CCTO:000968 implies CCTO:000049 CCTO:000968 implies CCTO:001126 CCTO:000968(time_t t0) = EVENT_STATE(CCTO:000968, t0) NCI:CTCAE:10033279 NCIT:C78513 UMLS:C0269164 cancer_care_treatment_outcome CCTO:000968 Ovarian rupture CCTO:000968 Tearing or disruption of the ovarian tissue OR A disorder characterized by tearing or disruption of the ovarian tissue. NCI:CTCAE NCIT:C78513 Painful sensation in one side of the abdomen between menstrual cycles, around the time of the discharge of the ovum from the ovarian follicle OR A disorder characterized by marked discomfort sensation in one side of the abdomen between menstrual cycles, around the time of the discharge of the ovum from the ovarian follicle OR Painful sensation in one side of the abdomen between menstrual cycles, around the time of the discharge of the ovum from the ovarian follicle. CCTO:000969 implies CCTO:000107 CCTO:000969 implies CCTO:001126 CCTO:000969(time_t t0) = EVENT_STATE(CCTO:000969, t0) NCI:CTCAE:10033314 NCIT:C78514 NCIT:C79700 UMLS:C0152149 UMLS:C1963168 Ovulatory pain cancer_care_treatment_outcome CCTO:000969 Ovulation pain CCTO:000969 Painful sensation in one side of the abdomen between menstrual cycles, around the time of the discharge of the ovum from the ovarian follicle OR A disorder characterized by marked discomfort sensation in one side of the abdomen between menstrual cycles, around the time of the discharge of the ovum from the ovarian follicle OR Painful sensation in one side of the abdomen between menstrual cycles, around the time of the discharge of the ovum from the ovarian follicle. NCI:CTCAE NCIT:C78514 NCIT:C79700 Ovulatory pain NCIT:C78514 A disorder characterized by a reduction in the strength of the muscles of the pelvic floor OR A reduction in the strength of the muscles of the pelvic floor. CCTO:000970 implies CCTO:000049 CCTO:000970 implies CCTO:001126 CCTO:000970(time_t t0) = EVENT_STATE(CCTO:000970, t0) NCI:CTCAE:10064026 NCIT:C78524 UMLS:C1535916 cancer_care_treatment_outcome CCTO:000970 Pelvic floor muscle weakness CCTO:000970 A disorder characterized by a reduction in the strength of the muscles of the pelvic floor OR A reduction in the strength of the muscles of the pelvic floor. NCI:CTCAE NCIT:C78524 Painful sensation in the pelvis OR A disorder characterized by marked discomfort sensation in the pelvis. CCTO:000971 implies CCTO:000107 CCTO:000971 implies CCTO:001126 CCTO:000971(time_t t0) = EVENT_STATE(CCTO:000971, t0) NCI:CTCAE:10034263 NCIT:C40122 UMLS:C0030794 UMLS:C0850758 cancer_care_treatment_outcome CCTO:000971 Pelvic pain CCTO:000971 Painful sensation in the pelvis OR A disorder characterized by marked discomfort sensation in the pelvis. NCI:CTCAE NCIT:C40122 A disorder characterized by marked discomfort sensation in the penis OR Painful sensation in the penis. CCTO:000972 implies CCTO:000107 CCTO:000972 implies CCTO:001126 CCTO:000972(time_t t0) = EVENT_STATE(CCTO:000972, t0) NCI:CTCAE:10034310 NCIT:C78527 UMLS:C0497481 cancer_care_treatment_outcome CCTO:000972 Penile pain CCTO:000972 A disorder characterized by marked discomfort sensation in the penis OR Painful sensation in the penis. NCI:CTCAE NCIT:C78527 A disorder characterized by a sensation of marked discomfort in the area between the genital organs and the anus OR Painful sensation in the perineal area. CCTO:000973 implies CCTO:000107 CCTO:000973 implies CCTO:001126 CCTO:000973(time_t t0) = EVENT_STATE(CCTO:000973, t0) NCI:CTCAE:10061339 NCIT:C78529 UMLS:C0240717 cancer_care_treatment_outcome CCTO:000973 Perineal pain CCTO:000973 A disorder characterized by a sensation of marked discomfort in the area between the genital organs and the anus OR Painful sensation in the perineal area. NCI:CTCAE NCIT:C78529 A disorder characterized by ovarian failure before the age of 40. Symptoms include hot flashes, night sweats, mood swings and a decrease in sex drive OR Cessation of menstruation before the age of 40. Symptoms include hot flashes, night sweats, mood swings, and decreased sex drive. CCTO:000974 implies CCTO:000049 CCTO:000974 implies CCTO:001126 CCTO:000974(time_t t0) = EVENT_STATE(CCTO:000974, t0) NCI:CTCAE:10036601 NCIT:C80099 UMLS:C0025322 UMLS:C0085215 POF Premature ovarian failure early menopause cancer_care_treatment_outcome CCTO:000974 Premature menopause CCTO:000974 A disorder characterized by ovarian failure before the age of 40. Symptoms include hot flashes, night sweats, mood swings and a decrease in sex drive OR Cessation of menstruation before the age of 40. Symptoms include hot flashes, night sweats, mood swings, and decreased sex drive. NCI:CTCAE NCIT:C80099 POF NCIT:C80099 Premature ovarian failure NCIT:C80099 early menopause NCIT:C80099 Bleeding originating from the prostate gland OR A disorder characterized by bleeding from the prostate gland. CCTO:000975 implies CCTO:000049 CCTO:000975 implies CCTO:001126 CCTO:000975(time_t t0) = EVENT_STATE(CCTO:000975, t0) NCI:CTCAE:10055325 NCIT:C78572 UMLS:C0268891 cancer_care_treatment_outcome CCTO:000975 Prostatic hemorrhage CCTO:000975 Bleeding originating from the prostate gland OR A disorder characterized by bleeding from the prostate gland. NCI:CTCAE NCIT:C78572 A disorder characterized by compression of the urethra secondary to enlargement of the prostate gland. This results in voiding difficulties (straining to void, slow urine stream, and incomplete emptying of the bladder) OR Squeezing of the urethra secondary to enlargement of the prostate gland, resulting in voiding symptoms (straining to void, slow urine stream, and incomplete emptying of the bladder). CCTO:000976 implies CCTO:000049 CCTO:000976 implies CCTO:001126 CCTO:000976(time_t t0) = EVENT_STATE(CCTO:000976, t0) NCI:CTCAE:10055026 NCIT:C78573 UMLS:C0268889 cancer_care_treatment_outcome CCTO:000976 Prostatic obstruction CCTO:000976 A disorder characterized by compression of the urethra secondary to enlargement of the prostate gland. This results in voiding difficulties (straining to void, slow urine stream, and incomplete emptying of the bladder) OR Squeezing of the urethra secondary to enlargement of the prostate gland, resulting in voiding symptoms (straining to void, slow urine stream, and incomplete emptying of the bladder). NCI:CTCAE NCIT:C78573 A disorder characterized by a sensation of marked discomfort in the prostate gland OR Pain in the prostate gland. CCTO:000977 implies CCTO:000107 CCTO:000977 implies CCTO:001126 CCTO:000977(time_t t0) = EVENT_STATE(CCTO:000977, t0) NCI:CTCAE:10036968 NCIT:C78574 UMLS:C0240812 cancer_care_treatment_outcome CCTO:000977 Prostatic pain CCTO:000977 A disorder characterized by a sensation of marked discomfort in the prostate gland OR Pain in the prostate gland. NCI:CTCAE NCIT:C78574 Painful sensation in the scrotal area OR A disorder characterized by marked discomfort sensation in the scrotal area. CCTO:000978 implies CCTO:000107 CCTO:000978 implies CCTO:001126 CCTO:000978(time_t t0) = EVENT_STATE(CCTO:000978, t0) NCI:CTCAE:10039757 NCIT:C78607 UMLS:C0236078 cancer_care_treatment_outcome CCTO:000978 Scrotal pain CCTO:000978 Painful sensation in the scrotal area OR A disorder characterized by marked discomfort sensation in the scrotal area. NCI:CTCAE NCIT:C78607 Bleeding originating from the spermatic cord OR A disorder characterized by bleeding from the spermatic cord. CCTO:000979 implies CCTO:000049 CCTO:000979 implies CCTO:001126 CCTO:000979(time_t t0) = EVENT_STATE(CCTO:000979, t0) NCI:CTCAE:10065762 NCIT:C56563 NCIT:C78623 UMLS:C0268940 UMLS:C1963130 Spermatic cord hemorrhage adverse event cancer_care_treatment_outcome CCTO:000979 Spermatic cord hemorrhage CCTO:000979 Bleeding originating from the spermatic cord OR A disorder characterized by bleeding from the spermatic cord. NCI:CTCAE NCIT:C78623 Spermatic cord hemorrhage adverse event NCIT:C56563 Blockage of the normal flow of the contents of the spermatic cord OR A disorder characterized by blockage of the normal flow of the contents of the spermatic cord. CCTO:000980 implies CCTO:000049 CCTO:000980 implies CCTO:001126 CCTO:000980(time_t t0) = EVENT_STATE(CCTO:000980, t0) NCI:CTCAE:10065805 NCIT:C57077 NCIT:C78624 UMLS:C1557933 UMLS:C1963241 Spermatic cord obstruction adverse event cancer_care_treatment_outcome CCTO:000980 Spermatic cord obstruction CCTO:000980 Blockage of the normal flow of the contents of the spermatic cord OR A disorder characterized by blockage of the normal flow of the contents of the spermatic cord. NCI:CTCAE NCIT:C78624 Spermatic cord obstruction adverse event NCIT:C57077 A non-neoplastic or neoplastic disorder affecting the testis. Representative examples include torsion, infarction, germ cell tumor, sex cord-stromal tumor, lymphoma, and leukemia OR A disorder characterized by involvement of the testis. CCTO:000981 implies CCTO:000049 CCTO:000981 implies CCTO:001126 CCTO:000981(time_t t0) = EVENT_STATE(CCTO:000981, t0) NCI:CTCAE:10043306 NCIT:C26890 UMLS:C0039584 Testicular disease cancer_care_treatment_outcome CCTO:000981 Testicular disorder CCTO:000981 A non-neoplastic or neoplastic disorder affecting the testis. Representative examples include torsion, infarction, germ cell tumor, sex cord-stromal tumor, lymphoma, and leukemia OR A disorder characterized by involvement of the testis. NCI:CTCAE NCIT:C26890 Testicular disease NCIT:C26890 Bleeding originating from the testis OR A disorder characterized by bleeding from the testis. CCTO:000982 implies CCTO:000049 CCTO:000982 implies CCTO:001126 CCTO:000982(time_t t0) = EVENT_STATE(CCTO:000982, t0) NCI:CTCAE:10055347 NCIT:C78635 UMLS:C0268969 cancer_care_treatment_outcome CCTO:000982 Testicular hemorrhage CCTO:000982 Bleeding originating from the testis OR A disorder characterized by bleeding from the testis. NCI:CTCAE NCIT:C78635 A painful sensation in the testis OR A disorder characterized by a sensation of marked discomfort in the testis. CCTO:000983 implies CCTO:000107 CCTO:000983 implies CCTO:001126 CCTO:000983(time_t t0) = EVENT_STATE(CCTO:000983, t0) NCI:CTCAE:10043345 NCIT:C78636 UMLS:C0039591 cancer_care_treatment_outcome CCTO:000983 Testicular pain CCTO:000983 A painful sensation in the testis OR A disorder characterized by a sensation of marked discomfort in the testis. NCI:CTCAE NCIT:C78636 An abnormal communication between the uterus and another organ OR A disorder characterized by an abnormal communication between the uterus and another organ or anatomic site. CCTO:000984 implies CCTO:000049 CCTO:000984 implies CCTO:001126 CCTO:000984(time_t t0) = EVENT_STATE(CCTO:000984, t0) NCI:CTCAE:10065811 NCIT:C78685 UMLS:C1696087 cancer_care_treatment_outcome CCTO:000984 Uterine fistula CCTO:000984 An abnormal communication between the uterus and another organ OR A disorder characterized by an abnormal communication between the uterus and another organ or anatomic site. NCI:CTCAE NCIT:C78685 Bleeding originating from the uterus OR A disorder characterized by bleeding from the uterus. CCTO:000985 implies CCTO:000049 CCTO:000985 implies CCTO:001126 CCTO:000985(time_t t0) = EVENT_STATE(CCTO:000985, t0) NCI:CTCAE:10046789 NCIT:C78686 UMLS:C0042134 cancer_care_treatment_outcome CCTO:000985 Uterine hemorrhage CCTO:000985 Bleeding originating from the uterus OR A disorder characterized by bleeding from the uterus. NCI:CTCAE NCIT:C78686 Blockage of the uterine outlet. Causes include uterine tumors and adhesions OR A disorder characterized by blockage of the uterine outlet. CCTO:000986 implies CCTO:000049 CCTO:000986 implies CCTO:001126 CCTO:000986(time_t t0) = EVENT_STATE(CCTO:000986, t0) NCI:CTCAE:10065928 NCIT:C78693 UMLS:C1696113 cancer_care_treatment_outcome CCTO:000986 Uterine obstruction CCTO:000986 Blockage of the uterine outlet. Causes include uterine tumors and adhesions OR A disorder characterized by blockage of the uterine outlet. NCI:CTCAE NCIT:C78693 A painful sensation in the uterus OR A disorder characterized by a sensation of marked discomfort in the uterus. CCTO:000987 implies CCTO:000107 CCTO:000987 implies CCTO:001126 CCTO:000987(time_t t0) = EVENT_STATE(CCTO:000987, t0) NCI:CTCAE:10046809 NCIT:C78694 UMLS:C0567085 cancer_care_treatment_outcome CCTO:000987 Uterine pain CCTO:000987 A painful sensation in the uterus OR A disorder characterized by a sensation of marked discomfort in the uterus. NCI:CTCAE NCIT:C78694 A disorder characterized by vaginal secretions. Mucus produced by the cervical glands is discharged from the vagina naturally, especially during the childbearing years OR Normal or abnormal secretions from the vagina. Mucus produced by the cervical glands is discharged from the vagina naturally, especially during the childbearing years. Causes of abnormal vaginal discharge include infectious agents (e.g., Neisseria gonorrhea, Chlamydia trachomatis, Trichomonas, and Candida albicans), the presence of foreign bodies, and cervical or vaginal cancer. CCTO:000988 implies CCTO:000049 CCTO:000988 implies CCTO:001126 CCTO:000988(time_t t0) = EVENT_STATE(CCTO:000988, t0) NCI:CTCAE:10046901 NCIT:C50795 UMLS:C0227791 Discharge, vaginal cancer_care_treatment_outcome CCTO:000988 Vaginal discharge CCTO:000988 A disorder characterized by vaginal secretions. Mucus produced by the cervical glands is discharged from the vagina naturally, especially during the childbearing years OR Normal or abnormal secretions from the vagina. Mucus produced by the cervical glands is discharged from the vagina naturally, especially during the childbearing years. Causes of abnormal vaginal discharge include infectious agents (e.g., Neisseria gonorrhea, Chlamydia trachomatis, Trichomonas, and Candida albicans), the presence of foreign bodies, and cervical or vaginal cancer. NCI:CTCAE NCIT:C50795 Discharge, vaginal NCIT:C50795 An uncomfortable feeling of itching and burning in the vaginal opening resulting from inadequate vaginal lubrication. It is commonly seen during and after menopause, childbirth, or stressful conditions. It results in painful intercourse OR A disorder characterized by an uncomfortable feeling of itching and burning in the vagina OR A question about whether an individual is or was bothered by vaginal dryness. CCTO:000989 implies CCTO:000049 CCTO:000989 implies CCTO:001126 CCTO:000989(time_t t0) = EVENT_STATE(CCTO:000989, t0) NCI:CTCAE:10046904 NCIT:C125650 NCIT:C55645 NCIT:C78699 UMLS:C0241633 UMLS:C1963268 Bothered by Vaginal Dryness Vaginal dryness adverse event cancer_care_treatment_outcome CCTO:000989 Vaginal dryness CCTO:000989 An uncomfortable feeling of itching and burning in the vaginal opening resulting from inadequate vaginal lubrication. It is commonly seen during and after menopause, childbirth, or stressful conditions. It results in painful intercourse OR A disorder characterized by an uncomfortable feeling of itching and burning in the vagina OR A question about whether an individual is or was bothered by vaginal dryness. NCI:CTCAE NCIT:C125650 NCIT:C78699 Bothered by Vaginal Dryness NCIT:C125650 Vaginal dryness adverse event NCIT:C55645 A disorder characterized by an abnormal communication between the vagina and another organ or anatomic site OR An abnormal communication between the vagina and another organ or cavity. CCTO:000990 implies CCTO:000049 CCTO:000990 implies CCTO:001126 CCTO:000990(time_t t0) = EVENT_STATE(CCTO:000990, t0) NCI:CTCAE:10065813 NCIT:C79847 UMLS:C0042253 Fistulous Opening in Vagina cancer_care_treatment_outcome CCTO:000990 Vaginal fistula CCTO:000990 A disorder characterized by an abnormal communication between the vagina and another organ or anatomic site OR An abnormal communication between the vagina and another organ or cavity. NCI:CTCAE NCIT:C79847 Fistulous Opening in Vagina NCIT:C79847 A disorder characterized by bleeding from the vagina OR Bleeding originating from the vagina. CCTO:000991 implies CCTO:000049 CCTO:000991 implies CCTO:001126 CCTO:000991(time_t t0) = EVENT_STATE(CCTO:000991, t0) NCI:CTCAE:10046912 NCIT:C26945 UMLS:C2979982 cancer_care_treatment_outcome CCTO:000991 Vaginal hemorrhage CCTO:000991 A disorder characterized by bleeding from the vagina OR Bleeding originating from the vagina. NCI:CTCAE NCIT:C26945 A disorder characterized by inflammation involving the vagina. Symptoms may include redness, edema, marked discomfort and an increase in vaginal discharge OR A non-infectious or infectious inflammatory process affecting the vagina. CCTO:000992 implies CCTO:000049 CCTO:000992 implies CCTO:001126 CCTO:000992(time_t t0) = EVENT_STATE(CCTO:000992, t0) NCI:CTCAE:10046916 NCIT:C26911 UMLS:C0042267 Vaginitis cancer_care_treatment_outcome CCTO:000992 Vaginal inflammation CCTO:000992 A disorder characterized by inflammation involving the vagina. Symptoms may include redness, edema, marked discomfort and an increase in vaginal discharge OR A non-infectious or infectious inflammatory process affecting the vagina. NCI:CTCAE NCIT:C26911 Vaginitis NCIT:C26911 A disorder characterized by blockage of vaginal canal OR Congenital or acquired blockage of the vagina. CCTO:000993 implies CCTO:000049 CCTO:000993 implies CCTO:001126 CCTO:000993(time_t t0) = EVENT_STATE(CCTO:000993, t0) NCI:CTCAE:10065817 NCIT:C78700 UMLS:C1408443 cancer_care_treatment_outcome CCTO:000993 Vaginal obstruction CCTO:000993 A disorder characterized by blockage of vaginal canal OR Congenital or acquired blockage of the vagina. NCI:CTCAE NCIT:C78700 A disorder characterized by a sensation of marked discomfort in the vagina OR A painful sensation in the vagina. CCTO:000994 implies CCTO:000107 CCTO:000994 implies CCTO:001126 CCTO:000994(time_t t0) = EVENT_STATE(CCTO:000994, t0) NCI:CTCAE:10046937 NCIT:C78701 UMLS:C0236082 cancer_care_treatment_outcome CCTO:000994 Vaginal pain CCTO:000994 A disorder characterized by a sensation of marked discomfort in the vagina OR A painful sensation in the vagina. NCI:CTCAE NCIT:C78701 A disorder characterized by a rupture in the vaginal wall OR A rupture in the vaginal wall due to traumatic or pathologic processes. CCTO:000995 implies CCTO:000049 CCTO:000995 implies CCTO:001126 CCTO:000995(time_t t0) = EVENT_STATE(CCTO:000995, t0) NCI:CTCAE:10065818 NCIT:C78702 UMLS:C1696155 cancer_care_treatment_outcome CCTO:000995 Vaginal perforation CCTO:000995 A disorder characterized by a rupture in the vaginal wall OR A rupture in the vaginal wall due to traumatic or pathologic processes. NCI:CTCAE NCIT:C78702 Narrowing of the vaginal lumen OR A disorder characterized by a narrowing of the vaginal canal. CCTO:000996 implies CCTO:000049 CCTO:000996 implies CCTO:001126 CCTO:000996(time_t t0) = EVENT_STATE(CCTO:000996, t0) NCI:CTCAE:10053496 NCIT:C36064 UMLS:C0269208 cancer_care_treatment_outcome CCTO:000996 Vaginal stricture CCTO:000996 Narrowing of the vaginal lumen OR A disorder characterized by a narrowing of the vaginal canal. NCI:CTCAE NCIT:C36064 Tightness of the vaginal wall during vaginal penetration including sexual intercourse. It is caused by involuntary spasm of the pelvic floor muscles, and results in painful intercourse or failure to have intercourse. It may due to psychological conditions, trauma in the vaginal area, or vaginal infection OR A disorder characterized by involuntary spasms of the pelvic floor muscles, resulting in pathologic tightness of the vaginal wall during penetration such as during sexual intercourse. CCTO:000997 implies CCTO:000049 CCTO:000997 implies CCTO:001126 CCTO:000997(time_t t0) = EVENT_STATE(CCTO:000997, t0) NCI:CTCAE:10046947 NCIT:C78703 UMLS:C0042266 UMLS:C2004487 cancer_care_treatment_outcome CCTO:000997 Vaginismus CCTO:000997 Tightness of the vaginal wall during vaginal penetration including sexual intercourse. It is caused by involuntary spasm of the pelvic floor muscles, and results in painful intercourse or failure to have intercourse. It may due to psychological conditions, trauma in the vaginal area, or vaginal infection OR A disorder characterized by involuntary spasms of the pelvic floor muscles, resulting in pathologic tightness of the vaginal wall during penetration such as during sexual intercourse. NCI:CTCAE NCIT:C78703 Progressive and life-threatening pulmonary distress in the absence of an underlying pulmonary condition, usually following major trauma or surgery. Cases of neonatal respiratory distress syndrome are not included in this definition OR A disorder characterized by progressive and life-threatening pulmonary distress in the absence of an underlying pulmonary condition, usually following major trauma or surgery. CCTO:000998 implies CCTO:000049 CCTO:000998 implies CCTO:001127 CCTO:000998(time_t t0) = EVENT_STATE(CCTO:000998, t0) NCI:CTCAE:10001409 NCIT:C3353 UMLS:C0035222 ARDS Acute respiratory distress syndrome Adult RDS Adult Respiratory Distress Syndrome, ARDS cancer_care_treatment_outcome CCTO:000998 Adult respiratory distress syndrome CCTO:000998 Progressive and life-threatening pulmonary distress in the absence of an underlying pulmonary condition, usually following major trauma or surgery. Cases of neonatal respiratory distress syndrome are not included in this definition OR A disorder characterized by progressive and life-threatening pulmonary distress in the absence of an underlying pulmonary condition, usually following major trauma or surgery. NCI:CTCAE NCIT:C3353 ARDS NCIT:C3353 Acute respiratory distress syndrome NCIT:C3353 Adult RDS NCIT:C3353 Adult Respiratory Distress Syndrome, ARDS NCIT:C3353 Inflammation of the nasal mucous membranes caused by an IgE-mediated response to external allergens. The inflammation may also involve the mucous membranes of the sinuses, eyes, middle ear, and pharynx. Symptoms include sneezing, nasal congestion, rhinorrhea, and itching. It may lead to fatigue, drowsiness, and malaise thus causing impairment of the quality of life OR A disorder characterized by an inflammation of the nasal mucous membranes caused by an IgE-mediated response to external allergens. The inflammation may also involve the mucous membranes of the sinuses, eyes, middle ear, and pharynx. Symptoms include sneezing, nasal congestion, rhinorrhea and itching. CCTO:000999 implies CCTO:000049 CCTO:000999 implies CCTO:001127 CCTO:000999(time_t t0) = EVENT_STATE(CCTO:000999, t0) NCI:CTCAE:10001723 NCIT:C79532 UMLS:C1334103 UMLS:C2607914 cancer_care_treatment_outcome CCTO:000999 Allergic rhinitis CCTO:000999 Inflammation of the nasal mucous membranes caused by an IgE-mediated response to external allergens. The inflammation may also involve the mucous membranes of the sinuses, eyes, middle ear, and pharynx. Symptoms include sneezing, nasal congestion, rhinorrhea, and itching. It may lead to fatigue, drowsiness, and malaise thus causing impairment of the quality of life OR A disorder characterized by an inflammation of the nasal mucous membranes caused by an IgE-mediated response to external allergens. The inflammation may also involve the mucous membranes of the sinuses, eyes, middle ear, and pharynx. Symptoms include sneezing, nasal congestion, rhinorrhea and itching. NCI:CTCAE NCIT:C79532 A disorder characterized by cessation of breathing OR Transient cessation of respiration. CCTO:001000 implies CCTO:000049 CCTO:001000 implies CCTO:001127 CCTO:001000(time_t t0) = EVENT_STATE(CCTO:001000, t0) NCI:CTCAE:10002972 NCIT:C26698 NCIT:C55340 UMLS:C0003578 UMLS:C0162297 UMLS:C1963065 Apnea adverse event Arrest, respiratory Respiratory arrest cancer_care_treatment_outcome CCTO:001000 Apnea CCTO:001000 A disorder characterized by cessation of breathing OR Transient cessation of respiration. NCI:CTCAE NCIT:C26698 Apnea adverse event NCIT:C55340 Arrest, respiratory NCIT:C26698 Respiratory arrest NCIT:C26698 Procedure using suction, usually with a thin needle and syringe, to remove bodily fluid or tissue OR Accidental inhalation of a foreign material into the lungs OR A disorder characterized by inhalation of solids or liquids into the lungs OR The entry of foreign material past the trachea, and into the lower respiratory tract. Oro-pharyngeal or gastric secretions are the most commonly aspirated materials, and can cause a pneumonitis or pneumonia. CCTO:001001 implies CCTO:000049 CCTO:001001 implies CCTO:001127 CCTO:001001(time_t t0) = EVENT_STATE(CCTO:001001, t0) NCI:CTCAE:10003504 NCIT:C15631 NCIT:C28245 NCIT:C83507 UMLS:C0349707 UMLS:C1963221 UMLS:C2827071 Aspiration adverse event Respiratory tract aspiration Unintentional material aspiration cancer_care_treatment_outcome CCTO:001001 Aspiration CCTO:001001 Procedure using suction, usually with a thin needle and syringe, to remove bodily fluid or tissue OR Accidental inhalation of a foreign material into the lungs OR A disorder characterized by inhalation of solids or liquids into the lungs OR The entry of foreign material past the trachea, and into the lower respiratory tract. Oro-pharyngeal or gastric secretions are the most commonly aspirated materials, and can cause a pneumonitis or pneumonia. NCI:CTCAE NCIT:C15631 NCIT:C28245 NCIT:C83507 Aspiration adverse event NCIT:C28245 Respiratory tract aspiration NCIT:C83507 Unintentional material aspiration NCIT:C83507 A disorder characterized by the collapse of part or the entire lung OR The collapse of part or the entire lung due to airway obstruction, infection, tumor, or general anesthesia. CCTO:001002 implies CCTO:000049 CCTO:001002 implies CCTO:001127 CCTO:001002(time_t t0) = EVENT_STATE(CCTO:001002, t0) NCI:CTCAE:10003598 NCIT:C2888 NCIT:C58022 UMLS:C0004144 UMLS:C1962948 Atelectasis adverse event UNEXPANDED LUNG cancer_care_treatment_outcome CCTO:001002 Atelectasis CCTO:001002 A disorder characterized by the collapse of part or the entire lung OR The collapse of part or the entire lung due to airway obstruction, infection, tumor, or general anesthesia. NCI:CTCAE NCIT:C2888 Atelectasis adverse event NCIT:C58022 UNEXPANDED LUNG NCIT:C2888 A disorder characterized by an abnormal communication between the bronchus and another organ or anatomic site OR An abnormal communication between the bronchus and another organ or anatomic site. CCTO:001003 implies CCTO:000049 CCTO:001003 implies CCTO:001127 CCTO:001003(time_t t0) = EVENT_STATE(CCTO:001003, t0) NCI:CTCAE:10006437 NCIT:C79543 UMLS:C0006262 cancer_care_treatment_outcome CCTO:001003 Bronchial fistula CCTO:001003 A disorder characterized by an abnormal communication between the bronchus and another organ or anatomic site OR An abnormal communication between the bronchus and another organ or anatomic site. NCI:CTCAE NCIT:C79543 A disorder characterized by blockage of a bronchus passage, most often by bronchial secretions and exudates OR Blockage of a bronchus passage most often by bronchial secretions and exudates. CCTO:001004 implies CCTO:000049 CCTO:001004 implies CCTO:001127 CCTO:001004(time_t t0) = EVENT_STATE(CCTO:001004, t0) NCI:CTCAE:10006440 NCIT:C78225 UMLS:C0221725 cancer_care_treatment_outcome CCTO:001004 Bronchial obstruction CCTO:001004 A disorder characterized by blockage of a bronchus passage, most often by bronchial secretions and exudates OR Blockage of a bronchus passage most often by bronchial secretions and exudates. NCI:CTCAE NCIT:C78225 Narrowing of a bronchial tube OR A disorder characterized by a narrowing of the bronchial tube. CCTO:001005 implies CCTO:000049 CCTO:001005 implies CCTO:001127 CCTO:001005(time_t t0) = EVENT_STATE(CCTO:001005, t0) NCI:CTCAE:10063524 NCIT:C78226 UMLS:C1504507 cancer_care_treatment_outcome CCTO:001005 Bronchial stricture CCTO:001005 Narrowing of a bronchial tube OR A disorder characterized by a narrowing of the bronchial tube. NCI:CTCAE NCIT:C78226 An abnormal communication between a bronchus and the pleural cavity OR A disorder characterized by an abnormal communication between a bronchus and the pleural cavity. CCTO:001006 implies CCTO:000049 CCTO:001006 implies CCTO:001127 CCTO:001006(time_t t0) = EVENT_STATE(CCTO:001006, t0) NCI:CTCAE:10053481 NCIT:C80694 UMLS:C0238132 cancer_care_treatment_outcome CCTO:001006 Bronchopleural fistula CCTO:001006 An abnormal communication between a bronchus and the pleural cavity OR A disorder characterized by an abnormal communication between a bronchus and the pleural cavity. NCI:CTCAE NCIT:C80694 A disorder characterized by bleeding from the bronchial wall and/or lung parenchyma OR Bleeding from the bronchial wall and/or lung parenchyma. CCTO:001007 implies CCTO:000049 CCTO:001007 implies CCTO:001127 CCTO:001007(time_t t0) = EVENT_STATE(CCTO:001007, t0) NCI:CTCAE:10065746 NCIT:C78224 UMLS:C1321133 UMLS:C1560774 Bronchial hemorrhage cancer_care_treatment_outcome CCTO:001007 Bronchopulmonary hemorrhage CCTO:001007 A disorder characterized by bleeding from the bronchial wall and/or lung parenchyma OR Bleeding from the bronchial wall and/or lung parenchyma. NCI:CTCAE NCIT:C78224 Bronchial hemorrhage NCIT:C78224 Sudden contraction of the smooth muscles of the bronchial wall OR A disorder characterized by a sudden contraction of the smooth muscles of the bronchial wall. CCTO:001008 implies CCTO:000049 CCTO:001008 implies CCTO:001127 CCTO:001008(time_t t0) = EVENT_STATE(CCTO:001008, t0) NCI:CTCAE:10006482 NCIT:C34439 UMLS:C0006266 cancer_care_treatment_outcome CCTO:001008 Bronchospasm CCTO:001008 Sudden contraction of the smooth muscles of the bronchial wall OR A disorder characterized by a sudden contraction of the smooth muscles of the bronchial wall. NCI:CTCAE NCIT:C34439 A disorder characterized by milky pleural effusion (abnormal collection of fluid) resulting from accumulation of lymph fluid in the pleural cavity OR A milky pleural effusion resulting from accumulation of lymph fluid in the pleural cavity. Causes include malignancies (usually lymphoma), trauma to the thoracic duct, tuberculosis, sarcoidosis, and congenital causes OR Chylothorax resulting from a known treatment. CCTO:001009 implies CCTO:000049 CCTO:001009 implies CCTO:001127 CCTO:001009(time_t t0) = EVENT_STATE(CCTO:001009, t0) NCI:CTCAE:10051228 NCIT:C58027 NCIT:C79546 UMLS:C0008733 UMLS:C1962974 Chylothorax adverse event cancer_care_treatment_outcome CCTO:001009 Chylothorax CCTO:001009 A disorder characterized by milky pleural effusion (abnormal collection of fluid) resulting from accumulation of lymph fluid in the pleural cavity OR A milky pleural effusion resulting from accumulation of lymph fluid in the pleural cavity. Causes include malignancies (usually lymphoma), trauma to the thoracic duct, tuberculosis, sarcoidosis, and congenital causes OR Chylothorax resulting from a known treatment. NCI:CTCAE NCIT:C58027 NCIT:C79546 Chylothorax adverse event NCIT:C58027 A sudden, often repetitive, spasmodic contraction of the thoracic cavity, resulting in violent release of air from the lungs, and usually accompanied by a distinctive sound OR A question about the frequency of an individual's cough OR A question about the usual severity of an individual's cough OR A disorder characterized by sudden, often repetitive, spasmodic contraction of the thoracic cavity, resulting in violent release of air from the lungs and usually accompanied by a distinctive sound OR A question about an individual's distress from their cough OR A question about whether an individual is or has been coughing. CCTO:001010 implies CCTO:000049 CCTO:001010 implies CCTO:001127 CCTO:001010(time_t t0) = EVENT_STATE(CCTO:001010, t0) NCI:CTCAE:10011224 NCIT:C124215 NCIT:C125301 NCIT:C125333 NCIT:C37935 NCIT:C58028 NCIT:C99778 UMLS:C0010200 UMLS:C1961131 UMLS:C3274924 Cough adverse event Cough distress Cough frequency Frequency of Coughing Have been coughing How much distress cough How often cough I have been coughing Usual severity cough cancer_care_treatment_outcome CCTO:001010 Cough CCTO:001010 A sudden, often repetitive, spasmodic contraction of the thoracic cavity, resulting in violent release of air from the lungs, and usually accompanied by a distinctive sound OR A question about the frequency of an individual's cough OR A question about the usual severity of an individual's cough OR A disorder characterized by sudden, often repetitive, spasmodic contraction of the thoracic cavity, resulting in violent release of air from the lungs and usually accompanied by a distinctive sound OR A question about an individual's distress from their cough OR A question about whether an individual is or has been coughing. NCI:CTCAE NCIT:C124215 NCIT:C125301 NCIT:C125333 NCIT:C37935 NCIT:C99778 Cough adverse event NCIT:C58028 Cough distress NCIT:C124215 Cough frequency NCIT:C124215 Frequency of Coughing NCIT:C124215 Have been coughing NCIT:C99778 How much distress cough NCIT:C125333 How often cough NCIT:C124215 I have been coughing NCIT:C99778 Usual severity cough NCIT:C125301 A disorder characterized by an uncomfortable sensation of difficulty breathing OR An uncomfortable sensation of difficulty breathing. It may present as an acute or chronic sign of an underlying respiratory or heart disorder. CCTO:001011 implies CCTO:000049 CCTO:001011 implies CCTO:001127 CCTO:001011(time_t t0) = EVENT_STATE(CCTO:001011, t0) NCI:CTCAE:10013963 NCIT:C2998 UMLS:C0013404 UMLS:C2707305 Breathing difficulties Difficulty breathing Shortness of Breath cancer_care_treatment_outcome CCTO:001011 Dyspnea CCTO:001011 A disorder characterized by an uncomfortable sensation of difficulty breathing OR An uncomfortable sensation of difficulty breathing. It may present as an acute or chronic sign of an underlying respiratory or heart disorder. NCI:CTCAE NCIT:C2998 Breathing difficulties NCIT:C2998 Difficulty breathing NCIT:C2998 Shortness of Breath NCIT:C2998 A disorder characterized by bleeding from the nose OR Bleeding from the nose. CCTO:001012 implies CCTO:000049 CCTO:001012 implies CCTO:001127 CCTO:001012(time_t t0) = EVENT_STATE(CCTO:001012, t0) NCI:CTCAE:10015090 NCIT:C26766 UMLS:C0014591 UMLS:C2724883 Nasal hemorrhage Nose bleed Nosebleed cancer_care_treatment_outcome CCTO:001012 Epistaxis CCTO:001012 A disorder characterized by bleeding from the nose OR Bleeding from the nose. NCI:CTCAE NCIT:C26766 Nasal hemorrhage NCIT:C26766 Nose bleed NCIT:C26766 Nosebleed NCIT:C26766 A disorder characterized by repeated gulp sounds that result from an involuntary opening and closing of the glottis. This is attributed to a spasm of the diaphragm OR An involuntary contraction of the diaphragm against closed vocal cords, producing the ''hic'' sound. CCTO:001013 implies CCTO:000049 CCTO:001013 implies CCTO:001127 CCTO:001013(time_t t0) = EVENT_STATE(CCTO:001013, t0) NCI:CTCAE:10020039 NCIT:C37966 UMLS:C0019521 Hiccough Hiccup Singultus cancer_care_treatment_outcome CCTO:001013 Hiccups CCTO:001013 A disorder characterized by repeated gulp sounds that result from an involuntary opening and closing of the glottis. This is attributed to a spasm of the diaphragm OR An involuntary contraction of the diaphragm against closed vocal cords, producing the ''hic'' sound. NCI:CTCAE NCIT:C37966 Hiccough NCIT:C37966 Hiccup NCIT:C37966 Singultus NCIT:C37966 A disorder characterized by harsh and raspy voice arising from or spreading to the larynx OR Harsh and raspy voice secondary to laryngeal infection, voice overuse, irritants inhalation, vocal cord paralysis, vocal cord polyps, and malignant neoplasms arising from or spreading to the larynx. CCTO:001014 implies CCTO:000049 CCTO:001014 implies CCTO:001127 CCTO:001014(time_t t0) = EVENT_STATE(CCTO:001014, t0) NCI:CTCAE:10020201 NCIT:C47813 UMLS:C0019825 UMLS:C1527344 Dysphonia cancer_care_treatment_outcome CCTO:001014 Hoarseness CCTO:001014 A disorder characterized by harsh and raspy voice arising from or spreading to the larynx OR Harsh and raspy voice secondary to laryngeal infection, voice overuse, irritants inhalation, vocal cord paralysis, vocal cord polyps, and malignant neoplasms arising from or spreading to the larynx. NCI:CTCAE NCIT:C47813 Dysphonia NCIT:C47813 A decrease in the amount of oxygen in the body. Symptoms range from mild (impaired judgment, memory loss, impaired motor coordination) to severe (seizures and coma) OR A disorder characterized by a decrease in the level of oxygen in the body. CCTO:001015 implies CCTO:000049 CCTO:001015 implies CCTO:001127 CCTO:001015(time_t t0) = EVENT_STATE(CCTO:001015, t0) NCI:CTCAE:10021143 NCIT:C3890 NCIT:C58188 UMLS:C0242184 UMLS:C1963140 Hypoxia adverse event Hypoxic cancer_care_treatment_outcome CCTO:001015 Hypoxia CCTO:001015 A decrease in the amount of oxygen in the body. Symptoms range from mild (impaired judgment, memory loss, impaired motor coordination) to severe (seizures and coma) OR A disorder characterized by a decrease in the level of oxygen in the body. NCI:CTCAE NCIT:C3890 Hypoxia adverse event NCIT:C58188 Hypoxic NCIT:C3890 Swelling due to an excessive accumulation of fluid in the larynx OR A disorder characterized by swelling due to an excessive accumulation of fluid in the larynx. CCTO:001016 implies CCTO:000226 CCTO:001016 implies CCTO:001127 CCTO:001016(time_t t0) = EVENT_STATE(CCTO:001016, t0) NCI:CTCAE:10023838 NCIT:C79607 UMLS:C0023052 cancer_care_treatment_outcome CCTO:001016 Laryngeal edema CCTO:001016 Swelling due to an excessive accumulation of fluid in the larynx OR A disorder characterized by swelling due to an excessive accumulation of fluid in the larynx. NCI:CTCAE NCIT:C79607 A disorder characterized by an abnormal communication between the larynx and another organ or anatomic site OR An abnormal communication between the larynx and another organ or cavity. CCTO:001017 implies CCTO:000049 CCTO:001017 implies CCTO:001127 CCTO:001017(time_t t0) = EVENT_STATE(CCTO:001017, t0) NCI:CTCAE:10065786 NCIT:C78410 UMLS:C1699588 cancer_care_treatment_outcome CCTO:001017 Laryngeal fistula CCTO:001017 A disorder characterized by an abnormal communication between the larynx and another organ or anatomic site OR An abnormal communication between the larynx and another organ or cavity. NCI:CTCAE NCIT:C78410 Bleeding originating from the larynx OR A disorder characterized by bleeding from the larynx. CCTO:001018 implies CCTO:000049 CCTO:001018 implies CCTO:001127 CCTO:001018(time_t t0) = EVENT_STATE(CCTO:001018, t0) NCI:CTCAE:10065759 NCIT:C78411 UMLS:C1697747 cancer_care_treatment_outcome CCTO:001018 Laryngeal hemorrhage CCTO:001018 Bleeding originating from the larynx OR A disorder characterized by bleeding from the larynx. NCI:CTCAE NCIT:C78411 A disorder characterized by an inflammation involving the mucous membrane of the larynx OR An inflammatory process affecting the mucous membrane of the larynx. CCTO:001019 implies CCTO:000049 CCTO:001019 implies CCTO:001127 CCTO:001019(time_t t0) = EVENT_STATE(CCTO:001019, t0) NCI:CTCAE:10065880 NCIT:C78412 UMLS:C1698768 cancer_care_treatment_outcome CCTO:001019 Laryngeal mucositis CCTO:001019 A disorder characterized by an inflammation involving the mucous membrane of the larynx OR An inflammatory process affecting the mucous membrane of the larynx. NCI:CTCAE NCIT:C78412 A disorder characterized by blockage of the laryngeal airway OR Blockage of the laryngeal airway passage. CCTO:001020 implies CCTO:000049 CCTO:001020 implies CCTO:001127 CCTO:001020(time_t t0) = EVENT_STATE(CCTO:001020, t0) NCI:CTCAE:10059639 NCIT:C78413 UMLS:C0264306 cancer_care_treatment_outcome CCTO:001020 Laryngeal obstruction CCTO:001020 A disorder characterized by blockage of the laryngeal airway OR Blockage of the laryngeal airway passage. NCI:CTCAE NCIT:C78413 Narrowing of the laryngeal airway OR A disorder characterized by a narrowing of the laryngeal airway. CCTO:001021 implies CCTO:000049 CCTO:001021 implies CCTO:001127 CCTO:001021(time_t t0) = EVENT_STATE(CCTO:001021, t0) NCI:CTCAE:10023862 NCIT:C79608 UMLS:C0023075 cancer_care_treatment_outcome CCTO:001021 Laryngeal stenosis CCTO:001021 Narrowing of the laryngeal airway OR A disorder characterized by a narrowing of the laryngeal airway. NCI:CTCAE NCIT:C79608 A disorder characterized by an uncomfortable persistent sensation in the area of the laryngopharynx OR A disorder characterized by an uncomfortable persistent sensation in the area of the laryngopharynx. CCTO:001022 implies CCTO:000049 CCTO:001022 implies CCTO:001127 CCTO:001022(time_t t0) = EVENT_STATE(CCTO:001022, t0) NCI:CTCAE:10062667 NCIT:C78414 UMLS:C1328466 cancer_care_treatment_outcome CCTO:001022 Laryngopharyngeal dysesthesia CCTO:001022 A disorder characterized by an uncomfortable persistent sensation in the area of the laryngopharynx OR A disorder characterized by an uncomfortable persistent sensation in the area of the laryngopharynx. NCI:CTCAE NCIT:C78414 Paroxysmal spasmodic muscular contraction of the vocal cords. It is brief, usually lasting for less than one minute, interrupting the speech and breathing and may produce a high-pitched breathing sound. It may occur under anesthesia or may be associated with gastroesophageal reflex disease OR A disorder characterized by paroxysmal spasmodic muscular contraction of the vocal cords. CCTO:001023 implies CCTO:000049 CCTO:001023 implies CCTO:001127 CCTO:001023(time_t t0) = EVENT_STATE(CCTO:001023, t0) NCI:CTCAE:10023891 NCIT:C79609 UMLS:C0023066 cancer_care_treatment_outcome CCTO:001023 Laryngospasm CCTO:001023 Paroxysmal spasmodic muscular contraction of the vocal cords. It is brief, usually lasting for less than one minute, interrupting the speech and breathing and may produce a high-pitched breathing sound. It may occur under anesthesia or may be associated with gastroesophageal reflex disease OR A disorder characterized by paroxysmal spasmodic muscular contraction of the vocal cords. NCI:CTCAE NCIT:C79609 A disorder characterized by bleeding from the mediastinum OR Bleeding originating from the mediastinum. CCTO:001024 implies CCTO:000049 CCTO:001024 implies CCTO:001127 CCTO:001024(time_t t0) = EVENT_STATE(CCTO:001024, t0) NCI:CTCAE:10056356 NCIT:C78443 UMLS:C1112480 cancer_care_treatment_outcome CCTO:001024 Mediastinal hemorrhage CCTO:001024 A disorder characterized by bleeding from the mediastinum OR Bleeding originating from the mediastinum. NCI:CTCAE NCIT:C78443 A disorder characterized by obstruction of the nasal passage due to mucosal edema OR The blockage of the nasal passage due to mucosal edema. It is usually the result of a viral infection or an allergic reaction. CCTO:001025 implies CCTO:000049 CCTO:001025 implies CCTO:001127 CCTO:001025(time_t t0) = EVENT_STATE(CCTO:001025, t0) NCI:CTCAE:10028735 NCIT:C78500 UMLS:C0027424 Nasal stuffiness cancer_care_treatment_outcome CCTO:001025 Nasal congestion CCTO:001025 A disorder characterized by obstruction of the nasal passage due to mucosal edema OR The blockage of the nasal passage due to mucosal edema. It is usually the result of a viral infection or an allergic reaction. NCI:CTCAE NCIT:C78500 Nasal stuffiness NCIT:C78500 An abnormal communication between the pharynx and another organ or anatomic site OR A disorder characterized by an abnormal communication between the pharynx and another organ or anatomic site. CCTO:001026 implies CCTO:000049 CCTO:001026 implies CCTO:001127 CCTO:001026(time_t t0) = EVENT_STATE(CCTO:001026, t0) NCI:CTCAE:10034825 NCIT:C78551 UMLS:C1536454 cancer_care_treatment_outcome CCTO:001026 Pharyngeal fistula CCTO:001026 An abnormal communication between the pharynx and another organ or anatomic site OR A disorder characterized by an abnormal communication between the pharynx and another organ or anatomic site. NCI:CTCAE NCIT:C78551 A disorder characterized by bleeding from the pharynx OR Bleeding originating from the pharynx. CCTO:001027 implies CCTO:000049 CCTO:001027 implies CCTO:001127 CCTO:001027(time_t t0) = EVENT_STATE(CCTO:001027, t0) NCI:CTCAE:10055315 NCIT:C26986 UMLS:C0576995 cancer_care_treatment_outcome CCTO:001027 Pharyngeal hemorrhage CCTO:001027 A disorder characterized by bleeding from the pharynx OR Bleeding originating from the pharynx. NCI:CTCAE NCIT:C26986 A disorder characterized by an inflammation involving the mucous membrane of the pharynx OR An inflammatory process affecting the mucous membrane of the pharynx. CCTO:001028 implies CCTO:000049 CCTO:001028 implies CCTO:001127 CCTO:001028(time_t t0) = EVENT_STATE(CCTO:001028, t0) NCI:CTCAE:10065881 NCIT:C78553 UMLS:C1699324 cancer_care_treatment_outcome CCTO:001028 Pharyngeal mucositis CCTO:001028 A disorder characterized by an inflammation involving the mucous membrane of the pharynx OR An inflammatory process affecting the mucous membrane of the pharynx. NCI:CTCAE NCIT:C78553 A necrotic process affecting the pharynx OR A disorder characterized by a necrotic process occurring in the pharynx. CCTO:001029 implies CCTO:000049 CCTO:001029 implies CCTO:001127 CCTO:001029(time_t t0) = EVENT_STATE(CCTO:001029, t0) NCI:CTCAE:10065706 NCIT:C78554 UMLS:C1696156 Pharyngeal necrotic lesion cancer_care_treatment_outcome CCTO:001029 Pharyngeal necrosis CCTO:001029 A necrotic process affecting the pharynx OR A disorder characterized by a necrotic process occurring in the pharynx. NCI:CTCAE NCIT:C78554 Pharyngeal necrotic lesion NCIT:C78554 A disorder characterized by a narrowing of the pharyngeal airway OR Narrowing of the pharyngeal airway. CCTO:001030 implies CCTO:000049 CCTO:001030 implies CCTO:001127 CCTO:001030(time_t t0) = EVENT_STATE(CCTO:001030, t0) NCI:CTCAE:10050028 NCIT:C78555 UMLS:C0396006 cancer_care_treatment_outcome CCTO:001030 Pharyngeal stenosis CCTO:001030 A disorder characterized by a narrowing of the pharyngeal airway OR Narrowing of the pharyngeal airway. NCI:CTCAE NCIT:C78555 A disorder characterized by marked discomfort sensation in the pharyngolaryngeal region OR Painful sensation in the pharyngolaryngeal region. CCTO:001031 implies CCTO:000107 CCTO:001031 implies CCTO:001127 CCTO:001031(time_t t0) = EVENT_STATE(CCTO:001031, t0) NCI:CTCAE:10034844 NCIT:C78556 UMLS:C0858635 cancer_care_treatment_outcome CCTO:001031 Pharyngolaryngeal pain CCTO:001031 A disorder characterized by marked discomfort sensation in the pharyngolaryngeal region OR Painful sensation in the pharyngolaryngeal region. NCI:CTCAE NCIT:C78556 A disorder characterized by an increase in amounts of fluid within the pleural cavity. Symptoms include shortness of breath, cough and marked chest discomfort OR Increased amounts of fluid within the pleural cavity. Symptoms include shortness of breath, cough, and chest pain. It is usually caused by lung infections, congestive heart failure, pleural and lung tumors, connective tissue disorders, and trauma. CCTO:001032 implies CCTO:000049 CCTO:001032 implies CCTO:001127 CCTO:001032(time_t t0) = EVENT_STATE(CCTO:001032, t0) NCI:CTCAE:10035598 NCIT:C3331 UMLS:C0032227 UMLS:C1253943 Effusion, pleural Pleural effusion, NOS cancer_care_treatment_outcome CCTO:001032 Pleural effusion CCTO:001032 A disorder characterized by an increase in amounts of fluid within the pleural cavity. Symptoms include shortness of breath, cough and marked chest discomfort OR Increased amounts of fluid within the pleural cavity. Symptoms include shortness of breath, cough, and chest pain. It is usually caused by lung infections, congestive heart failure, pleural and lung tumors, connective tissue disorders, and trauma. NCI:CTCAE NCIT:C3331 Effusion, pleural NCIT:C3331 Pleural effusion, NOS NCIT:C3331 A disorder characterized by bleeding from the pleural cavity OR A collection of blood in the pleural cavity. CCTO:001033 implies CCTO:000049 CCTO:001033 implies CCTO:001127 CCTO:001033(time_t t0) = EVENT_STATE(CCTO:001033, t0) NCI:CTCAE:10055319 NCIT:C50582 NCIT:C78562 UMLS:C0019123 Hemothorax cancer_care_treatment_outcome CCTO:001033 Pleural hemorrhage CCTO:001033 A disorder characterized by bleeding from the pleural cavity OR A collection of blood in the pleural cavity. NCI:CTCAE NCIT:C50582 Hemothorax NCIT:C50582 A disorder characterized by marked discomfort sensation in the pleura OR Painful sensation in the pleura. CCTO:001034 implies CCTO:000107 CCTO:001034 implies CCTO:001127 CCTO:001034(time_t t0) = EVENT_STATE(CCTO:001034, t0) NCI:CTCAE:10035623 NCIT:C78564 UMLS:C0008033 cancer_care_treatment_outcome CCTO:001034 Pleuritic pain CCTO:001034 A disorder characterized by marked discomfort sensation in the pleura OR Painful sensation in the pleura. NCI:CTCAE NCIT:C78564 An inflammatory process affecting the lung parenchyma. It is a milder form of lung inflammation compared to pneumonia OR A disorder characterized by inflammation focally or diffusely affecting the lung parenchyma. CCTO:001035 implies CCTO:000049 CCTO:001035 implies CCTO:001127 CCTO:001035(time_t t0) = EVENT_STATE(CCTO:001035, t0) NCI:CTCAE:10035742 NCIT:C113159 UMLS:C3714636 cancer_care_treatment_outcome CCTO:001035 Pneumonitis CCTO:001035 An inflammatory process affecting the lung parenchyma. It is a milder form of lung inflammation compared to pneumonia OR A disorder characterized by inflammation focally or diffusely affecting the lung parenchyma. NCI:CTCAE NCIT:C113159 Abnormal presence of air in the pleural cavity OR A disorder characterized by abnormal presence of air in the pleural cavity resulting in the collapse of the lung. CCTO:001036 implies CCTO:000049 CCTO:001036 implies CCTO:001127 CCTO:001036(time_t t0) = EVENT_STATE(CCTO:001036, t0) NCI:CTCAE:10035759 NCIT:C38006 NCIT:C58201 UMLS:C0032326 UMLS:C1963215 Pneumothorax adverse event cancer_care_treatment_outcome CCTO:001036 Pneumothorax CCTO:001036 Abnormal presence of air in the pleural cavity OR A disorder characterized by abnormal presence of air in the pleural cavity resulting in the collapse of the lung. NCI:CTCAE NCIT:C38006 Pneumothorax adverse event NCIT:C58201 Excessive mucous secretion in the back of the nasal cavity or throat, causing sore throat and/or coughing. It is usually due to allergic rhinitis or a cold OR A disorder characterized by excessive mucous secretion in the back of the nasal cavity or throat, causing sore throat and/or coughing. CCTO:001037 implies CCTO:000049 CCTO:001037 implies CCTO:001127 CCTO:001037(time_t t0) = EVENT_STATE(CCTO:001037, t0) NCI:CTCAE:10036402 NCIT:C78566 UMLS:C0032781 Post-nasal drip cancer_care_treatment_outcome CCTO:001037 Postnasal drip CCTO:001037 Excessive mucous secretion in the back of the nasal cavity or throat, causing sore throat and/or coughing. It is usually due to allergic rhinitis or a cold OR A disorder characterized by excessive mucous secretion in the back of the nasal cavity or throat, causing sore throat and/or coughing. NCI:CTCAE NCIT:C78566 Post-nasal drip NCIT:C78566 A cough accompanied by expectorated secretions OR A disorder characterized by expectorated secretions upon coughing. CCTO:001038 implies CCTO:000049 CCTO:001038 implies CCTO:001127 CCTO:001038(time_t t0) = EVENT_STATE(CCTO:001038, t0) NCI:CTCAE:10036790 NCIT:C78569 UMLS:C0239134 Loose cough Wet cough cancer_care_treatment_outcome CCTO:001038 Productive cough CCTO:001038 A cough accompanied by expectorated secretions OR A disorder characterized by expectorated secretions upon coughing. NCI:CTCAE NCIT:C78569 Loose cough NCIT:C78569 Wet cough NCIT:C78569 Accumulation of fluid in the lung tissues causing disturbance of the gas exchange that may lead to respiratory failure. It is caused by direct injury to the lung parenchyma or congestive heart failure. The symptoms may appear suddenly or gradually. Suddenly appearing symptoms include difficulty breathing, feeling of suffocation, and coughing associated with frothy sputum. Gradually appearing symptoms include difficulty breathing while lying in bed, shortness of breath during activity, and weight gain (in patients with congestive heart failure) OR A disorder characterized by accumulation of fluid in the lung tissues that causes a disturbance of the gas exchange that may lead to respiratory failure. CCTO:001039 implies CCTO:000226 CCTO:001039 implies CCTO:001127 CCTO:001039(time_t t0) = EVENT_STATE(CCTO:001039, t0) NCI:CTCAE:10037375 NCIT:C26868 UMLS:C0034063 Edema, pulmonary cancer_care_treatment_outcome CCTO:001039 Pulmonary edema CCTO:001039 Accumulation of fluid in the lung tissues causing disturbance of the gas exchange that may lead to respiratory failure. It is caused by direct injury to the lung parenchyma or congestive heart failure. The symptoms may appear suddenly or gradually. Suddenly appearing symptoms include difficulty breathing, feeling of suffocation, and coughing associated with frothy sputum. Gradually appearing symptoms include difficulty breathing while lying in bed, shortness of breath during activity, and weight gain (in patients with congestive heart failure) OR A disorder characterized by accumulation of fluid in the lung tissues that causes a disturbance of the gas exchange that may lead to respiratory failure. NCI:CTCAE NCIT:C26868 Edema, pulmonary NCIT:C26868 Chronic progressive interstitial lung disorder characterized by the replacement of the lung tissue by connective tissue, leading to progressive dyspnea, respiratory failure, or right heart failure. Causes include chronic inflammatory processes, exposure to environmental irritants, radiation therapy, autoimmune disorders, certain drugs, or it may be idiopathic (no identifiable cause) OR A disorder characterized by the replacement of the lung tissue by connective tissue, leading to progressive dyspnea, respiratory failure or right heart failure. CCTO:001040 implies CCTO:000049 CCTO:001040 implies CCTO:001127 CCTO:001040(time_t t0) = EVENT_STATE(CCTO:001040, t0) NCI:CTCAE:10037383 NCIT:C26869 UMLS:C0034069 UMLS:C0240035 Pulmonary interstitial fibrosis cancer_care_treatment_outcome CCTO:001040 Pulmonary fibrosis CCTO:001040 Chronic progressive interstitial lung disorder characterized by the replacement of the lung tissue by connective tissue, leading to progressive dyspnea, respiratory failure, or right heart failure. Causes include chronic inflammatory processes, exposure to environmental irritants, radiation therapy, autoimmune disorders, certain drugs, or it may be idiopathic (no identifiable cause) OR A disorder characterized by the replacement of the lung tissue by connective tissue, leading to progressive dyspnea, respiratory failure or right heart failure. NCI:CTCAE NCIT:C26869 Pulmonary interstitial fibrosis NCIT:C26869 An abnormal communication between the lung and another organ or anatomic site OR A disorder characterized by an abnormal communication between the lung and another organ or anatomic site. CCTO:001041 implies CCTO:000049 CCTO:001041 implies CCTO:001127 CCTO:001041(time_t t0) = EVENT_STATE(CCTO:001041, t0) NCI:CTCAE:10065873 NCIT:C78577 UMLS:C1397452 cancer_care_treatment_outcome CCTO:001041 Pulmonary fistula CCTO:001041 An abnormal communication between the lung and another organ or anatomic site OR A disorder characterized by an abnormal communication between the lung and another organ or anatomic site. NCI:CTCAE NCIT:C78577 Increased pressure within the pulmonary circulation due to lung or heart disorder OR A disorder characterized by an increase in pressure within the pulmonary circulation due to lung or heart disorder. CCTO:001042 implies CCTO:000049 CCTO:001042 implies CCTO:001127 CCTO:001042(time_t t0) = EVENT_STATE(CCTO:001042, t0) NCI:CTCAE:10037400 NCIT:C3120 NCIT:C55068 UMLS:C0020542 UMLS:C1963220 Pulmonary hypertension adverse event cancer_care_treatment_outcome CCTO:001042 Pulmonary hypertension CCTO:001042 Increased pressure within the pulmonary circulation due to lung or heart disorder OR A disorder characterized by an increase in pressure within the pulmonary circulation due to lung or heart disorder. NCI:CTCAE NCIT:C3120 Pulmonary hypertension adverse event NCIT:C55068 The significant impairment of gas exchange within the lungs resulting in hypoxia, hypercarbia, or both, to the extent that organ tissue perfusion is severely compromised. Causes include chronic obstructive pulmonary disease, asthma, emphysema, acute respiratory distress syndrome, pneumonia, pulmonary edema, pneumothorax, and congestive heart failure. Treatment requires intubation and mechanical ventilation until the time the lungs recover sufficient function OR A disorder characterized by impaired gas exchange by the respiratory system resulting in hypoxemia and a decrease in oxygenation of the tissues that may be associated with an increase in arterial levels of carbon dioxide. CCTO:001043 implies CCTO:000049 CCTO:001043 implies CCTO:001127 CCTO:001043(time_t t0) = EVENT_STATE(CCTO:001043, t0) NCI:CTCAE:10038695 NCIT:C26872 UMLS:C1145670 Failure, respiratory cancer_care_treatment_outcome CCTO:001043 Respiratory failure CCTO:001043 The significant impairment of gas exchange within the lungs resulting in hypoxia, hypercarbia, or both, to the extent that organ tissue perfusion is severely compromised. Causes include chronic obstructive pulmonary disease, asthma, emphysema, acute respiratory distress syndrome, pneumonia, pulmonary edema, pneumothorax, and congestive heart failure. Treatment requires intubation and mechanical ventilation until the time the lungs recover sufficient function OR A disorder characterized by impaired gas exchange by the respiratory system resulting in hypoxemia and a decrease in oxygenation of the tissues that may be associated with an increase in arterial levels of carbon dioxide. NCI:CTCAE NCIT:C26872 Failure, respiratory NCIT:C26872 A syndrome observed in patients with acute promyelocytic leukemia treated with all-trans retinoic acid. It is characterized by weight gain, dyspnea, pleural and pericardial effusions, leukocytosis, and renal failure OR A disorder characterized by weight gain, dyspnea, pleural and pericardial effusions, leukocytosis and/or renal failure originally described in patients treated with all-trans retinoic acid. CCTO:001044 implies CCTO:000049 CCTO:001044 implies CCTO:001127 CCTO:001044(time_t t0) = EVENT_STATE(CCTO:001044, t0) NCI:CTCAE:10038921 NCIT:C56635 NCIT:C78597 UMLS:C0860564 UMLS:C1962967 APL Differentiation Syndrome Differentiation syndrome Retinoic acid syndrome adverse event cancer_care_treatment_outcome CCTO:001044 Retinoic acid syndrome CCTO:001044 A syndrome observed in patients with acute promyelocytic leukemia treated with all-trans retinoic acid. It is characterized by weight gain, dyspnea, pleural and pericardial effusions, leukocytosis, and renal failure OR A disorder characterized by weight gain, dyspnea, pleural and pericardial effusions, leukocytosis and/or renal failure originally described in patients treated with all-trans retinoic acid. NCI:CTCAE NCIT:C78597 APL Differentiation Syndrome NCIT:C78597 Differentiation syndrome NCIT:C78597 Retinoic acid syndrome adverse event NCIT:C56635 A non-neoplastic or neoplastic disorder affecting the paranasal sinuses. Examples include inflammation, polyps, and cancer OR A disorder characterized by involvement of the paranasal sinuses. CCTO:001045 implies CCTO:000049 CCTO:001045 implies CCTO:001127 CCTO:001045(time_t t0) = EVENT_STATE(CCTO:001045, t0) NCI:CTCAE:10062244 NCIT:C26843 UMLS:C0030469 Paranasal sinus disease Paranasal sinus disorder cancer_care_treatment_outcome CCTO:001045 Sinus disorder CCTO:001045 A non-neoplastic or neoplastic disorder affecting the paranasal sinuses. Examples include inflammation, polyps, and cancer OR A disorder characterized by involvement of the paranasal sinuses. NCI:CTCAE NCIT:C26843 Paranasal sinus disease NCIT:C26843 Paranasal sinus disorder NCIT:C26843 Cessation of breathing for short periods during sleep. It is classified as obstructive, central, or mixed obstructive-central. It can occur at any age but it is more frequent in people over forty. Risk factors include male sex and obesity OR A disorder characterized by cessation of breathing for short periods during sleep. CCTO:001046 implies CCTO:000049 CCTO:001046 implies CCTO:001127 CCTO:001046(time_t t0) = EVENT_STATE(CCTO:001046, t0) NCI:CTCAE:10040975 NCIT:C26884 UMLS:C0037315 cancer_care_treatment_outcome CCTO:001046 Sleep apnea CCTO:001046 Cessation of breathing for short periods during sleep. It is classified as obstructive, central, or mixed obstructive-central. It can occur at any age but it is more frequent in people over forty. Risk factors include male sex and obesity OR A disorder characterized by cessation of breathing for short periods during sleep. NCI:CTCAE NCIT:C26884 A symptom consisting of the involuntary expulsion of air from the nose OR A disorder characterized by the involuntary expulsion of air from the nose. CCTO:001047 implies CCTO:000049 CCTO:001047 implies CCTO:001127 CCTO:001047(time_t t0) = EVENT_STATE(CCTO:001047, t0) NCI:CTCAE:10041232 NCIT:C50746 UMLS:C0037383 cancer_care_treatment_outcome CCTO:001047 Sneezing CCTO:001047 A symptom consisting of the involuntary expulsion of air from the nose OR A disorder characterized by the involuntary expulsion of air from the nose. NCI:CTCAE NCIT:C50746 A disorder characterized by a high pitched breathing sound due to laryngeal or upper airway obstruction OR A symptom resulting from laryngeal obstruction. It is characterized by a high pitched breathing sound. CCTO:001048 implies CCTO:000049 CCTO:001048 implies CCTO:001127 CCTO:001048(time_t t0) = EVENT_STATE(CCTO:001048, t0) NCI:CTCAE:10042241 NCIT:C78632 UMLS:C0038450 cancer_care_treatment_outcome CCTO:001048 Stridor CCTO:001048 A disorder characterized by a high pitched breathing sound due to laryngeal or upper airway obstruction OR A symptom resulting from laryngeal obstruction. It is characterized by a high pitched breathing sound. NCI:CTCAE NCIT:C78632 A disorder characterized by an abnormal communication between the trachea and another organ or anatomic site OR An abnormal communication between the trachea and another organ or anatomic site. CCTO:001049 implies CCTO:000049 CCTO:001049 implies CCTO:001127 CCTO:001049(time_t t0) = EVENT_STATE(CCTO:001049, t0) NCI:CTCAE:10065787 NCIT:C78641 UMLS:C0340214 cancer_care_treatment_outcome CCTO:001049 Tracheal fistula CCTO:001049 A disorder characterized by an abnormal communication between the trachea and another organ or anatomic site OR An abnormal communication between the trachea and another organ or anatomic site. NCI:CTCAE NCIT:C78641 A disorder characterized by an inflammation involving the mucous membrane of the trachea OR An inflammatory process affecting the mucous membrane of the trachea. CCTO:001050 implies CCTO:000049 CCTO:001050 implies CCTO:001127 CCTO:001050(time_t t0) = EVENT_STATE(CCTO:001050, t0) NCI:CTCAE:10065900 NCIT:C78644 UMLS:C1699329 cancer_care_treatment_outcome CCTO:001050 Tracheal mucositis CCTO:001050 A disorder characterized by an inflammation involving the mucous membrane of the trachea OR An inflammatory process affecting the mucous membrane of the trachea. NCI:CTCAE NCIT:C78644 Narrowing of the lumen of the trachea OR A disorder characterized by a narrowing of the trachea. CCTO:001051 implies CCTO:000049 CCTO:001051 implies CCTO:001127 CCTO:001051(time_t t0) = EVENT_STATE(CCTO:001051, t0) NCI:CTCAE:10050816 NCIT:C78646 UMLS:C0040583 cancer_care_treatment_outcome CCTO:001051 Tracheal stenosis CCTO:001051 Narrowing of the lumen of the trachea OR A disorder characterized by a narrowing of the trachea. NCI:CTCAE NCIT:C78646 A disorder characterized by a change in the sound and/or speed of the voice OR Change in the sound and/or speed of the voice. Causes include laryngeal polyp, laryngitis, laryngeal carcinoma, throat carcinoma, Parkinson's disease, multiple sclerosis, stroke, hypothyroidism, oral surgery, tracheostomy, tracheal injury, and laryngeal injury. CCTO:001052 implies CCTO:000049 CCTO:001052 implies CCTO:001127 CCTO:001052(time_t t0) = EVENT_STATE(CCTO:001052, t0) NCI:CTCAE:10047681 NCIT:C61043 UMLS:C0518179 UMLS:C1527340 Change in Voice cancer_care_treatment_outcome CCTO:001052 Voice alteration CCTO:001052 A disorder characterized by a change in the sound and/or speed of the voice OR Change in the sound and/or speed of the voice. Causes include laryngeal polyp, laryngitis, laryngeal carcinoma, throat carcinoma, Parkinson's disease, multiple sclerosis, stroke, hypothyroidism, oral surgery, tracheostomy, tracheal injury, and laryngeal injury. NCI:CTCAE NCIT:C61043 Change in Voice NCIT:C61043 A disorder characterized by a high-pitched, whistling sound during breathing. It results from the narrowing or obstruction of the respiratory airways OR A symptom and a finding during physical examination, characterized by a high-pitched, whistling sound during breathing. It results from the narrowing or obstruction of the respiratory airways. The most common causes of wheezing are asthma, chronic obstructive pulmonary disease, tracheobronchitis, and pulmonary edema. CCTO:001053 implies CCTO:000049 CCTO:001053 implies CCTO:001127 CCTO:001053(time_t t0) = EVENT_STATE(CCTO:001053, t0) NCI:CTCAE:10047924 NCIT:C78718 UMLS:C0043144 Wheeze cancer_care_treatment_outcome CCTO:001053 Wheezing CCTO:001053 A disorder characterized by a high-pitched, whistling sound during breathing. It results from the narrowing or obstruction of the respiratory airways OR A symptom and a finding during physical examination, characterized by a high-pitched, whistling sound during breathing. It results from the narrowing or obstruction of the respiratory airways. The most common causes of wheezing are asthma, chronic obstructive pulmonary disease, tracheobronchitis, and pulmonary edema. NCI:CTCAE NCIT:C78718 Wheeze NCIT:C78718 Hair loss usually from the scalp. It may result in bald spots or spread to the entire scalp or the entire epidermis. It may be androgenetic or caused by chemotherapeutic agents, compulsive hair pulling, autoimmune disorders or congenital conditions OR Hair loss usually from the scalp. It may result in bald spots or spread to the entire scalp or the entire epidermis. It may be androgenetic or caused by chemotherapeutic agents, compulsive hair pulling, autoimmune disorders, and congenital conditions OR A disorder characterized by a decrease in density of hair compared to normal for a given individual at a given age and body location. CCTO:001054 implies CCTO:000049 CCTO:001054 implies CCTO:001128 CCTO:001054(time_t t0) = EVENT_STATE(CCTO:001054, t0) NCI:CTCAE:10001760 NCIT:C2865 NCIT:C50575 UMLS:C0002170 UMLS:C0002171 Alopecia areata Hair loss Loss of hair cancer_care_treatment_outcome CCTO:001054 Alopecia CCTO:001054 Hair loss usually from the scalp. It may result in bald spots or spread to the entire scalp or the entire epidermis. It may be androgenetic or caused by chemotherapeutic agents, compulsive hair pulling, autoimmune disorders or congenital conditions OR Hair loss usually from the scalp. It may result in bald spots or spread to the entire scalp or the entire epidermis. It may be androgenetic or caused by chemotherapeutic agents, compulsive hair pulling, autoimmune disorders, and congenital conditions OR A disorder characterized by a decrease in density of hair compared to normal for a given individual at a given age and body location. NCI:CTCAE NCIT:C2865 NCIT:C50575 Alopecia areata NCIT:C50575 Hair loss NCIT:C50575 Loss of hair NCIT:C50575 Body smell resulting from the growth of bacteria on the body OR A disorder characterized by an abnormal body smell resulting from the growth of bacteria on the body. CCTO:001055 implies CCTO:000049 CCTO:001055 implies CCTO:001128 CCTO:001055(time_t t0) = EVENT_STATE(CCTO:001055, t0) NCI:CTCAE:10005901 NCIT:C79542 UMLS:C0085595 cancer_care_treatment_outcome CCTO:001055 Body odor CCTO:001055 Body smell resulting from the growth of bacteria on the body OR A disorder characterized by an abnormal body smell resulting from the growth of bacteria on the body. NCI:CTCAE NCIT:C79542 A disorder characterized by inflammation of the skin characterized by the presence of bullae which are filled with fluid OR Inflammation of the skin characterized by the presence of bullae which are filled with fluid. CCTO:001056 implies CCTO:000049 CCTO:001056 implies CCTO:001128 CCTO:001056(time_t t0) = EVENT_STATE(CCTO:001056, t0) NCI:CTCAE:10006556 NCIT:C35149 UMLS:C0085932 cancer_care_treatment_outcome CCTO:001056 Bullous dermatitis CCTO:001056 A disorder characterized by inflammation of the skin characterized by the presence of bullae which are filled with fluid OR Inflammation of the skin characterized by the presence of bullae which are filled with fluid. NCI:CTCAE NCIT:C35149 A disorder characterized by flaky and dull skin; the pores are generally fine, the texture is a papery thin texture OR The pores are generally fine with a papery thin texture that feels dry to the touch. Usually flaky and dull looking. CCTO:001057 implies CCTO:000049 CCTO:001057 implies CCTO:001128 CCTO:001057(time_t t0) = EVENT_STATE(CCTO:001057, t0) NCI:CTCAE:10013786 NCIT:C57996 NCIT:C74592 UMLS:C0151908 UMLS:C0205222 UMLS:C0720057 UMLS:C1963094 DRY Dry skin adverse event cancer_care_treatment_outcome CCTO:001057 Dry skin CCTO:001057 A disorder characterized by flaky and dull skin; the pores are generally fine, the texture is a papery thin texture OR The pores are generally fine with a papery thin texture that feels dry to the touch. Usually flaky and dull looking. NCI:CTCAE NCIT:C74592 DRY NCIT:C74592 Dry skin adverse event NCIT:C57996 A hypersensitivity reaction characterized by the sudden appearance of symmetrical cutaneous and mucocutaneous macular or papular lesions which evolve into lesions with bright red borders (target lesions). The lesions usually appear in the hands, feet, extremities, and face. Symptoms include fever, malaise, sore throat, cough, vomiting, diarrhea, arthralgia, and myalgia. Causes include infections (most commonly herpes simplex virus), drugs (e.g., sulfonamides, anticonvulsants, and antibiotics), malignancies, and collagen vascular disorders OR A disorder characterized by target lesions (a pink-red ring around a pale center). CCTO:001058 implies CCTO:000049 CCTO:001058 implies CCTO:001128 CCTO:001058(time_t t0) = EVENT_STATE(CCTO:001058, t0) NCI:CTCAE:10015218 NCIT:C3024 UMLS:C0014742 cancer_care_treatment_outcome CCTO:001058 Erythema multiforme CCTO:001058 A hypersensitivity reaction characterized by the sudden appearance of symmetrical cutaneous and mucocutaneous macular or papular lesions which evolve into lesions with bright red borders (target lesions). The lesions usually appear in the hands, feet, extremities, and face. Symptoms include fever, malaise, sore throat, cough, vomiting, diarrhea, arthralgia, and myalgia. Causes include infections (most commonly herpes simplex virus), drugs (e.g., sulfonamides, anticonvulsants, and antibiotics), malignancies, and collagen vascular disorders OR A disorder characterized by target lesions (a pink-red ring around a pale center). NCI:CTCAE NCIT:C3024 A disorder characterized by generalized inflammatory erythema and exfoliation. The inflammatory process involves > 90% of the body surface area OR A generalized inflammatory cutaneous disorder characterized by erythema and desquamation. CCTO:001059 implies CCTO:000049 CCTO:001059 implies CCTO:001128 CCTO:001059(time_t t0) = EVENT_STATE(CCTO:001059, t0) NCI:CTCAE:10015277 NCIT:C39646 UMLS:C0011606 Exfoliative dermatitis cancer_care_treatment_outcome CCTO:001059 Erythroderma CCTO:001059 A disorder characterized by generalized inflammatory erythema and exfoliation. The inflammatory process involves > 90% of the body surface area OR A generalized inflammatory cutaneous disorder characterized by erythema and desquamation. NCI:CTCAE NCIT:C39646 Exfoliative dermatitis NCIT:C39646 A disorder characterized by shrinking of adipose tissue OR Shrinking of adipose tissue. CCTO:001060 implies CCTO:000049 CCTO:001060 implies CCTO:001128 CCTO:001060(time_t t0) = EVENT_STATE(CCTO:001060, t0) NCI:CTCAE:10016241 NCIT:C78297 UMLS:C0333650 Adipose tissue atrophy cancer_care_treatment_outcome CCTO:001060 Fat atrophy CCTO:001060 A disorder characterized by shrinking of adipose tissue OR Shrinking of adipose tissue. NCI:CTCAE NCIT:C78297 Adipose tissue atrophy NCIT:C78297 A disorder characterized by the presence of excess hair growth in women in anatomic sites where growth is considered to be a secondary male characteristic and under androgen control (beard, moustache, chest, abdomen) OR Male-pattern hair growth on a female. CCTO:001061 implies CCTO:000049 CCTO:001061 implies CCTO:001128 CCTO:001061(time_t t0) = EVENT_STATE(CCTO:001061, t0) NCI:CTCAE:10020112 NCIT:C61444 UMLS:C0019572 cancer_care_treatment_outcome CCTO:001061 Hirsutism CCTO:001061 A disorder characterized by the presence of excess hair growth in women in anatomic sites where growth is considered to be a secondary male characteristic and under androgen control (beard, moustache, chest, abdomen) OR Male-pattern hair growth on a female. NCI:CTCAE NCIT:C61444 A disorder characterized by excessive perspiration OR Excessive perspiration. CCTO:001062 implies CCTO:000049 CCTO:001062 implies CCTO:001128 CCTO:001062(time_t t0) = EVENT_STATE(CCTO:001062, t0) NCI:CTCAE:10020642 NCIT:C78345 UMLS:C0020458 Hyperhydrosis cancer_care_treatment_outcome CCTO:001062 Hyperhidrosis CCTO:001062 A disorder characterized by excessive perspiration OR Excessive perspiration. NCI:CTCAE NCIT:C78345 Hyperhydrosis NCIT:C78345 A disorder characterized by hair density or length beyond the accepted limits of normal in a particular body region, for a particular age or race OR Excessive hair growth anywhere on the body. CCTO:001063 implies CCTO:000049 CCTO:001063 implies CCTO:001128 CCTO:001063(time_t t0) = EVENT_STATE(CCTO:001063, t0) NCI:CTCAE:10020864 NCIT:C79597 UMLS:C0020555 cancer_care_treatment_outcome CCTO:001063 Hypertrichosis CCTO:001063 A disorder characterized by hair density or length beyond the accepted limits of normal in a particular body region, for a particular age or race OR Excessive hair growth anywhere on the body. NCI:CTCAE NCIT:C79597 Reduced sweating. Causes include burns, dehydration, radiation, and leprosy OR A disorder characterized by reduced sweating. CCTO:001064 implies CCTO:000049 CCTO:001064 implies CCTO:001128 CCTO:001064(time_t t0) = EVENT_STATE(CCTO:001064, t0) NCI:CTCAE:10021013 NCIT:C34718 UMLS:C0020620 cancer_care_treatment_outcome CCTO:001064 Hypohidrosis CCTO:001064 Reduced sweating. Causes include burns, dehydration, radiation, and leprosy OR A disorder characterized by reduced sweating. NCI:CTCAE NCIT:C34718 A disorder characterized by hypertrophy of the subcutaneous adipose tissue at the site of multiple subcutaneous injections of insulin OR Hypertrophy of the subcutaneous adipose tissue at the site of multiple subcutaneous injections of insulin. CCTO:001065 implies CCTO:000049 CCTO:001065 implies CCTO:001128 CCTO:001065(time_t t0) = EVENT_STATE(CCTO:001065, t0) NCI:CTCAE:10062315 NCIT:C78436 UMLS:C1262113 cancer_care_treatment_outcome CCTO:001065 Lipohypertrophy CCTO:001065 A disorder characterized by hypertrophy of the subcutaneous adipose tissue at the site of multiple subcutaneous injections of insulin OR Hypertrophy of the subcutaneous adipose tissue at the site of multiple subcutaneous injections of insulin. NCI:CTCAE NCIT:C78436 A disorder characterized by a change in the color of the nail plate OR A change in the color of the nail. CCTO:001066 implies CCTO:000049 CCTO:001066 implies CCTO:001128 CCTO:001066(time_t t0) = EVENT_STATE(CCTO:001066, t0) NCI:CTCAE:10028691 NCIT:C78492 UMLS:C0221345 Chromonychia Pigmentary Change of Nails cancer_care_treatment_outcome CCTO:001066 Nail discoloration CCTO:001066 A disorder characterized by a change in the color of the nail plate OR A change in the color of the nail. NCI:CTCAE NCIT:C78492 Chromonychia NCIT:C78492 Pigmentary Change of Nails NCIT:C78492 A disorder characterized by loss of all or a portion of the nail OR Loss of all or a portion of a nail. CCTO:001067 implies CCTO:000049 CCTO:001067 implies CCTO:001128 CCTO:001067(time_t t0) = EVENT_STATE(CCTO:001067, t0) NCI:CTCAE:10049281 NCIT:C78494 UMLS:C0263540 cancer_care_treatment_outcome CCTO:001067 Nail loss CCTO:001067 A disorder characterized by loss of all or a portion of the nail OR Loss of all or a portion of a nail. NCI:CTCAE NCIT:C78494 Straight elevated lines on the nail surface. Ridges may be vertical (running from the cuticle to the nail tip) or horizontal (running from one side of the nail to the other). Vertical ridges are usually not associated with underlying disorders and tend to become more pronounced with age. Horizontal ridges may be associated with metabolic disorders and malnutrition OR A disorder characterized by vertical or horizontal ridges on the nails. CCTO:001068 implies CCTO:000049 CCTO:001068 implies CCTO:001128 CCTO:001068(time_t t0) = EVENT_STATE(CCTO:001068, t0) NCI:CTCAE:10062283 NCIT:C78499 UMLS:C0423820 cancer_care_treatment_outcome CCTO:001068 Nail ridging CCTO:001068 Straight elevated lines on the nail surface. Ridges may be vertical (running from the cuticle to the nail tip) or horizontal (running from one side of the nail to the other). Vertical ridges are usually not associated with underlying disorders and tend to become more pronounced with age. Horizontal ridges may be associated with metabolic disorders and malnutrition OR A disorder characterized by vertical or horizontal ridges on the nails. NCI:CTCAE NCIT:C78499 Painful sensation in the skin OR A disorder characterized by marked discomfort sensation in the skin. CCTO:001069 implies CCTO:000049 CCTO:001069 implies CCTO:001128 CCTO:001069(time_t t0) = EVENT_STATE(CCTO:001069, t0) NCI:CTCAE:10033474 NCIT:C78516 UMLS:C0241136 UMLS:C1963195 Skin pain cancer_care_treatment_outcome CCTO:001069 Pain of skin CCTO:001069 Painful sensation in the skin OR A disorder characterized by marked discomfort sensation in the skin. NCI:CTCAE NCIT:C78516 Skin pain NCIT:C78516 A disorder characterized by redness, marked discomfort, swelling, and tingling in the palms of the hands or the soles of the feet OR A condition characterized by redness, pain, swelling, and tingling in the palms of the hands or the soles of the feet. It may appear as a side effect to chemotherapy agents. CCTO:001070 implies CCTO:000049 CCTO:001070 implies CCTO:001128 CCTO:001070(time_t t0) = EVENT_STATE(CCTO:001070, t0) NCI:CTCAE:10054524 NCIT:C27177 UMLS:C0549410 Hand-foot syndrome Palmar-plantar erythodysthesia palmar-plantar erythrodysthesia cancer_care_treatment_outcome CCTO:001070 Palmar-plantar erythrodysesthesia syndrome CCTO:001070 A disorder characterized by redness, marked discomfort, swelling, and tingling in the palms of the hands or the soles of the feet OR A condition characterized by redness, pain, swelling, and tingling in the palms of the hands or the soles of the feet. It may appear as a side effect to chemotherapy agents. NCI:CTCAE NCIT:C27177 Hand-foot syndrome NCIT:C27177 Palmar-plantar erythodysthesia NCIT:C27177 palmar-plantar erythrodysthesia NCIT:C27177 Swelling due to an excessive accumulation of fluid around the orbits of the face OR A disorder characterized by swelling due to an excessive accumulation of fluid around the orbits of the face. CCTO:001071 implies CCTO:000226 CCTO:001071 implies CCTO:001128 CCTO:001071(time_t t0) = EVENT_STATE(CCTO:001071, t0) NCI:CTCAE:10054541 NCIT:C78530 UMLS:C0151205 cancer_care_treatment_outcome CCTO:001071 Periorbital edema CCTO:001071 Swelling due to an excessive accumulation of fluid around the orbits of the face OR A disorder characterized by swelling due to an excessive accumulation of fluid around the orbits of the face. NCI:CTCAE NCIT:C78530 A disorder characterized by an increase in sensitivity of the skin to light OR Increased sensitivity of the skin to light exposure. CCTO:001072 implies CCTO:000049 CCTO:001072 implies CCTO:001128 CCTO:001072(time_t t0) = EVENT_STATE(CCTO:001072, t0) NCI:CTCAE:10034966 NCIT:C38004 NCIT:C58005 UMLS:C0349506 UMLS:C1868677 UMLS:C2362621 Photosensitivity adverse event Skin photosensitivity cancer_care_treatment_outcome CCTO:001072 Photosensitivity CCTO:001072 A disorder characterized by an increase in sensitivity of the skin to light OR Increased sensitivity of the skin to light exposure. NCI:CTCAE NCIT:C38004 Photosensitivity adverse event NCIT:C58005 Skin photosensitivity NCIT:C38004 A disorder characterized by an intense itching sensation OR An intense itching sensation. CCTO:001073 implies CCTO:000049 CCTO:001073 implies CCTO:001128 CCTO:001073(time_t t0) = EVENT_STATE(CCTO:001073, t0) NCI:CTCAE:10037087 NCIT:C3344 UMLS:C0033774 UMLS:C1422257 Itch Itching Itching (pruritus) cancer_care_treatment_outcome CCTO:001073 Pruritus CCTO:001073 A disorder characterized by an intense itching sensation OR An intense itching sensation. NCI:CTCAE NCIT:C3344 Itch NCIT:C3344 Itching NCIT:C3344 Itching (pruritus) NCIT:C3344 A disorder characterized by hemorrhagic areas of the skin and mucous membrane. Newer lesions appear reddish in color. Older lesions are usually a darker purple color and eventually become a brownish-yellow color OR A small blood vessel hemorrhage into the skin and/or mucous membranes. Newer lesions appear reddish in color. Older lesions are usually a darker purple color and eventually become a brownish-yellow color. CCTO:001074 implies CCTO:000049 CCTO:001074 implies CCTO:001128 CCTO:001074(time_t t0) = EVENT_STATE(CCTO:001074, t0) NCI:CTCAE:10037549 NCIT:C78787 UMLS:C0034150 UMLS:C3463943 cancer_care_treatment_outcome CCTO:001074 Purpura CCTO:001074 A disorder characterized by hemorrhagic areas of the skin and mucous membrane. Newer lesions appear reddish in color. Older lesions are usually a darker purple color and eventually become a brownish-yellow color OR A small blood vessel hemorrhage into the skin and/or mucous membranes. Newer lesions appear reddish in color. Older lesions are usually a darker purple color and eventually become a brownish-yellow color. NCI:CTCAE NCIT:C78787 A disorder characterized by an eruption of papules and pustules, typically appearing in face, scalp, upper chest and back OR Cutaneous eruptions resembling acne, characterized by the presence of papulonodules, pustules, comedones, or cysts in the face, trunk, and extremities. Causes include infections and the use of certain medications (e.g., antibiotics and steroids). CCTO:001075 implies CCTO:000049 CCTO:001075 implies CCTO:001128 CCTO:001075(time_t t0) = EVENT_STATE(CCTO:001075, t0) NCI:CTCAE:10037847 NCIT:C35277 UMLS:C0234894 Acneiform dermatitis cancer_care_treatment_outcome CCTO:001075 Rash acneiform CCTO:001075 A disorder characterized by an eruption of papules and pustules, typically appearing in face, scalp, upper chest and back OR Cutaneous eruptions resembling acne, characterized by the presence of papulonodules, pustules, comedones, or cysts in the face, trunk, and extremities. Causes include infections and the use of certain medications (e.g., antibiotics and steroids). NCI:CTCAE NCIT:C35277 Acneiform dermatitis NCIT:C35277 A skin condition consisting of both macules and papules OR A disorder characterized by the presence of macules (flat) and papules (elevated). Also known as morbillform rash, it is one of the most common cutaneous adverse events, frequently affecting the upper trunk, spreading centripetally and associated with pruritis. CCTO:001076 implies CCTO:000049 CCTO:001076 implies CCTO:001128 CCTO:001076(time_t t0) = EVENT_STATE(CCTO:001076, t0) NCI:CTCAE:10037868 NCIT:C75579 UMLS:C0423791 Maculopapular lesion cancer_care_treatment_outcome CCTO:001076 Rash maculo-papular CCTO:001076 A skin condition consisting of both macules and papules OR A disorder characterized by the presence of macules (flat) and papules (elevated). Also known as morbillform rash, it is one of the most common cutaneous adverse events, frequently affecting the upper trunk, spreading centripetally and associated with pruritis. NCI:CTCAE NCIT:C75579 Maculopapular lesion NCIT:C75579 Painful sensation in the skin covering the top and the back of the head OR A disorder characterized by marked discomfort sensation in the skin covering the top and the back of the head. CCTO:001077 implies CCTO:000107 CCTO:001077 implies CCTO:001128 CCTO:001077(time_t t0) = EVENT_STATE(CCTO:001077, t0) NCI:CTCAE:10049120 NCIT:C56210 NCIT:C79716 UMLS:C0240940 UMLS:C1963231 Scalp pain adverse event cancer_care_treatment_outcome CCTO:001077 Scalp pain CCTO:001077 Painful sensation in the skin covering the top and the back of the head OR A disorder characterized by marked discomfort sensation in the skin covering the top and the back of the head. NCI:CTCAE NCIT:C79716 Scalp pain adverse event NCIT:C56210 The degeneration and thinning of the epidermis and dermis. It is usually a manifestation of aging OR A disorder characterized by the degeneration and thinning of the epidermis and dermis. CCTO:001078 implies CCTO:000049 CCTO:001078 implies CCTO:001128 CCTO:001078(time_t t0) = EVENT_STATE(CCTO:001078, t0) NCI:CTCAE:10040799 NCIT:C35163 UMLS:C0151514 Atrophic skin Atrophy of Skin cancer_care_treatment_outcome CCTO:001078 Skin atrophy CCTO:001078 The degeneration and thinning of the epidermis and dermis. It is usually a manifestation of aging OR A disorder characterized by the degeneration and thinning of the epidermis and dermis. NCI:CTCAE NCIT:C35163 Atrophic skin NCIT:C35163 Atrophy of Skin NCIT:C35163 A disorder characterized by an area of hardness in the skin OR An area of hardness in the skin. Causes include inflammatory process and infiltration of the skin by malignant neoplasms. CCTO:001079 implies CCTO:000049 CCTO:001079 implies CCTO:001128 CCTO:001079(time_t t0) = EVENT_STATE(CCTO:001079, t0) NCI:CTCAE:10051837 NCIT:C78611 UMLS:C0241075 cancer_care_treatment_outcome CCTO:001079 Skin induration CCTO:001079 A disorder characterized by an area of hardness in the skin OR An area of hardness in the skin. Causes include inflammatory process and infiltration of the skin by malignant neoplasms. NCI:CTCAE NCIT:C78611 A disorder characterized by circumscribed, inflammatory and necrotic erosive lesion on the skin OR A circumscribed and often suppurating skin crater which usually includes loss of skin integrity of the superficial skin or the mucous membranes. CCTO:001080 implies CCTO:000049 CCTO:001080 implies CCTO:001128 CCTO:001080(time_t t0) = EVENT_STATE(CCTO:001080, t0) NCI:CTCAE:10040947 NCIT:C54247 UMLS:C0037299 Skin ulcer cancer_care_treatment_outcome CCTO:001080 Skin ulceration CCTO:001080 A disorder characterized by circumscribed, inflammatory and necrotic erosive lesion on the skin OR A circumscribed and often suppurating skin crater which usually includes loss of skin integrity of the superficial skin or the mucous membranes. NCI:CTCAE NCIT:C54247 Skin ulcer NCIT:C54247 A systemic, serious, and life-threatening disorder characterized by lesions in the skin and mucous membranes that may lead to necrosis. The lesions may appear anywhere in the body but they occur more commonly in the palms, soles, dorsum of the hands, and extensor surfaces. The lesions are vesicular or necrotic in the center, surrounded by an erythematous zone and occupy less than 10% of the body surfaces. The appearance of the mucocutaneous lesions is preceded by an upper respiratory tract infection. It is an immune complex hypersensitivity reaction usually caused by drugs (e.g., sulfa, phenytoin, penicillin), viruses (e.g., herpes simplex, influenza, hepatitis), and malignancies (e.g., carcinoma and lymphoma) OR A disorder characterized by less than 10% total body skin area separation of dermis. The syndrome is thought to be a hypersensitivity complex affecting the skin and the mucous membranes. CCTO:001081 implies CCTO:000049 CCTO:001081 implies CCTO:001128 CCTO:001081(time_t t0) = EVENT_STATE(CCTO:001081, t0) NCI:CTCAE:10042033 NCIT:C79484 UMLS:C0038325 UMLS:C3241919 Erythema multiforme major Stevens johnson syndrome cancer_care_treatment_outcome CCTO:001081 Stevens-Johnson syndrome CCTO:001081 A systemic, serious, and life-threatening disorder characterized by lesions in the skin and mucous membranes that may lead to necrosis. The lesions may appear anywhere in the body but they occur more commonly in the palms, soles, dorsum of the hands, and extensor surfaces. The lesions are vesicular or necrotic in the center, surrounded by an erythematous zone and occupy less than 10% of the body surfaces. The appearance of the mucocutaneous lesions is preceded by an upper respiratory tract infection. It is an immune complex hypersensitivity reaction usually caused by drugs (e.g., sulfa, phenytoin, penicillin), viruses (e.g., herpes simplex, influenza, hepatitis), and malignancies (e.g., carcinoma and lymphoma) OR A disorder characterized by less than 10% total body skin area separation of dermis. The syndrome is thought to be a hypersensitivity complex affecting the skin and the mucous membranes. NCI:CTCAE NCIT:C79484 Erythema multiforme major NCIT:C79484 Stevens johnson syndrome NCIT:C79484 Local dilatation of small vessels resulting in red discoloration of the skin or mucous membranes OR A disorder characterized by local dilatation of small vessels resulting in red discoloration of the skin or mucous membranes. CCTO:001082 implies CCTO:000049 CCTO:001082 implies CCTO:001128 CCTO:001082(time_t t0) = EVENT_STATE(CCTO:001082, t0) NCI:CTCAE:10043189 NCIT:C28194 NCIT:C58017 UMLS:C0039446 UMLS:C1963248 Telangiectasia adverse event cancer_care_treatment_outcome CCTO:001082 Telangiectasia CCTO:001082 Local dilatation of small vessels resulting in red discoloration of the skin or mucous membranes OR A disorder characterized by local dilatation of small vessels resulting in red discoloration of the skin or mucous membranes. NCI:CTCAE NCIT:C28194 Telangiectasia adverse event NCIT:C58017 A disorder characterized by greater than 30% total body skin area separation of dermis. The syndrome is thought to be a hypersensitivity complex affecting the skin and the mucous membranes OR A systemic, serious, and life-threatening disorder characterized by erythematous and necrotic lesions in the skin and mucous membranes that are associated with bullous detachment of the epidermis. The epidermal and mucous membranes detachment leads to sepsis and may be fatal. The lesions appear throughout the body and occupy more than 30% of the body surfaces. It is a hypersensitivity reaction usually caused by drugs (e.g., sulfonamides, nonsteroidal anti-inflammatory drugs, anticonvulsants, and antiretroviral drugs). CCTO:001083 implies CCTO:000049 CCTO:001083 implies CCTO:001128 CCTO:001083(time_t t0) = EVENT_STATE(CCTO:001083, t0) NCI:CTCAE:10044223 NCIT:C79777 UMLS:C0014518 UMLS:C0205456 Lyell syndrome Lyell's Syndrome TEN cancer_care_treatment_outcome CCTO:001083 Toxic epidermal necrolysis CCTO:001083 A disorder characterized by greater than 30% total body skin area separation of dermis. The syndrome is thought to be a hypersensitivity complex affecting the skin and the mucous membranes OR A systemic, serious, and life-threatening disorder characterized by erythematous and necrotic lesions in the skin and mucous membranes that are associated with bullous detachment of the epidermis. The epidermal and mucous membranes detachment leads to sepsis and may be fatal. The lesions appear throughout the body and occupy more than 30% of the body surfaces. It is a hypersensitivity reaction usually caused by drugs (e.g., sulfonamides, nonsteroidal anti-inflammatory drugs, anticonvulsants, and antiretroviral drugs). NCI:CTCAE NCIT:C79777 Lyell syndrome NCIT:C79777 Lyell's Syndrome NCIT:C79777 TEN NCIT:C79777 A disorder characterized by an itchy skin eruption characterized by wheals with pale interiors and well-defined red margins OR A transient, itchy skin eruption characterized by wheals with pale interiors and red margins. CCTO:001084 implies CCTO:000049 CCTO:001084 implies CCTO:001128 CCTO:001084(time_t t0) = EVENT_STATE(CCTO:001084, t0) NCI:CTCAE:10046735 NCIT:C3432 UMLS:C0042109 Hives cancer_care_treatment_outcome CCTO:001084 Urticaria CCTO:001084 A disorder characterized by an itchy skin eruption characterized by wheals with pale interiors and well-defined red margins OR A transient, itchy skin eruption characterized by wheals with pale interiors and red margins. NCI:CTCAE NCIT:C3432 Hives NCIT:C3432 A disorder characterized by the permanent cessation of menses, usually defined by 12 consecutive months of amenorrhea in a woman over 45 years of age OR The permanent cessation of menses, usually defined by 6 to 12 months of amenorrhea in a woman over 45 years of age. CCTO:001085 implies CCTO:000049 CCTO:001085 implies CCTO:001129 CCTO:001085(time_t t0) = EVENT_STATE(CCTO:001085, t0) NCI:CTCAE:10027308 NCIT:C3231 UMLS:C0025320 Menopausal cancer_care_treatment_outcome CCTO:001085 Menopause CCTO:001085 A disorder characterized by the permanent cessation of menses, usually defined by 12 consecutive months of amenorrhea in a woman over 45 years of age OR The permanent cessation of menses, usually defined by 6 to 12 months of amenorrhea in a woman over 45 years of age. NCI:CTCAE NCIT:C3231 Menopausal NCIT:C3231 A disorder characterized by leakage of intravascular fluids into the extravascular space. This syndrome is observed in patients who demonstrate a state of generalized leaky capillaries following shock syndromes, low-flow states, ischemia-reperfusion injuries, toxemias, medications, or poisoning. It can lead to generalized edema and multiple organ failure OR A syndrome characterized by leakage of intravascular fluids into the extravascular space. This syndrome is observed in patients who demonstrate a state of generalized leaky capillaries following shock syndromes, low-flow states, ischemia-reperfusion injuries, toxemias, medications, or poisoning. It can lead to generalized edema and multiple organ failure. CCTO:001086 implies CCTO:000049 CCTO:001086 implies CCTO:001130 CCTO:001086(time_t t0) = EVENT_STATE(CCTO:001086, t0) NCI:CTCAE:10007196 NCIT:C62578 UMLS:C0265252 UMLS:C0343084 UMLS:C1558951 AVLS Acute vascular leak syndrome CLS cancer_care_treatment_outcome CCTO:001086 Capillary leak syndrome CCTO:001086 A disorder characterized by leakage of intravascular fluids into the extravascular space. This syndrome is observed in patients who demonstrate a state of generalized leaky capillaries following shock syndromes, low-flow states, ischemia-reperfusion injuries, toxemias, medications, or poisoning. It can lead to generalized edema and multiple organ failure OR A syndrome characterized by leakage of intravascular fluids into the extravascular space. This syndrome is observed in patients who demonstrate a state of generalized leaky capillaries following shock syndromes, low-flow states, ischemia-reperfusion injuries, toxemias, medications, or poisoning. It can lead to generalized edema and multiple organ failure. NCI:CTCAE NCIT:C62578 AVLS NCIT:C62578 Acute vascular leak syndrome NCIT:C62578 CLS NCIT:C62578 Reddening of the skin from a transient increase in blood flow OR A disorder characterized by episodic reddening of the face. CCTO:001087 implies CCTO:000049 CCTO:001087 implies CCTO:001130 CCTO:001087(time_t t0) = EVENT_STATE(CCTO:001087, t0) NCI:CTCAE:10016825 NCIT:C26775 NCIT:C57997 UMLS:C0016382 UMLS:C1962957 Flushed Flushing adverse event cancer_care_treatment_outcome CCTO:001087 Flushing CCTO:001087 Reddening of the skin from a transient increase in blood flow OR A disorder characterized by episodic reddening of the face. NCI:CTCAE NCIT:C26775 Flushed NCIT:C26775 Flushing adverse event NCIT:C57997 A disorder characterized by a localized collection of blood, usually clotted, in an organ, space, or tissue, due to a break in the wall of a blood vessel OR A localized collection of blood, usually clotted, in an organ, space, or tissue, due to a break in the wall of a blood vessel. CCTO:001088 implies CCTO:000049 CCTO:001088 implies CCTO:001130 CCTO:001088(time_t t0) = EVENT_STATE(CCTO:001088, t0) NCI:CTCAE:10019428 NCIT:C50579 NCIT:C56539 UMLS:C0018944 UMLS:C1962958 Hematoma adverse event cancer_care_treatment_outcome CCTO:001088 Hematoma CCTO:001088 A disorder characterized by a localized collection of blood, usually clotted, in an organ, space, or tissue, due to a break in the wall of a blood vessel OR A localized collection of blood, usually clotted, in an organ, space, or tissue, due to a break in the wall of a blood vessel. NCI:CTCAE NCIT:C50579 Hematoma adverse event NCIT:C56539 A disorder characterized by an uncomfortable and temporary sensation of intense body warmth, flushing, sometimes accompanied by sweating upon cooling OR A temporary feeling of intense body warmth, flushing, sometimes accompanied by sweating. A common, symptom of menopause; other conditions that can produce hot flushes include antidepressants and drugs blocking the effect of estrogens, carcinoid tumors and a sensitivity to sulfites or other food additives OR A question about an individual's assessment of how big a problem hot flashes have been OR A question about whether an individual is or was bothered by hot flashes. CCTO:001089 implies CCTO:000049 CCTO:001089 implies CCTO:001130 CCTO:001089(time_t t0) = EVENT_STATE(CCTO:001089, t0) NCI:CTCAE:10020407 NCIT:C125055 NCIT:C125645 NCIT:C3109 UMLS:C0600142 Bothered by Hot Flashes Flashes, hot Hot flash How Big a Problem Are Hot Flashes cancer_care_treatment_outcome CCTO:001089 Hot flashes CCTO:001089 A disorder characterized by an uncomfortable and temporary sensation of intense body warmth, flushing, sometimes accompanied by sweating upon cooling OR A temporary feeling of intense body warmth, flushing, sometimes accompanied by sweating. A common, symptom of menopause; other conditions that can produce hot flushes include antidepressants and drugs blocking the effect of estrogens, carcinoid tumors and a sensitivity to sulfites or other food additives OR A question about an individual's assessment of how big a problem hot flashes have been OR A question about whether an individual is or was bothered by hot flashes. NCI:CTCAE NCIT:C125055 NCIT:C125645 NCIT:C3109 Bothered by Hot Flashes NCIT:C125645 Flashes, hot NCIT:C3109 Hot flash NCIT:C3109 How Big a Problem Are Hot Flashes NCIT:C125055 Blood pressure that is abnormally high. CCTO:001090 implies CCTO:000049 CCTO:001090 implies CCTO:001130 CCTO:001090(time_t t0) = EVENT_STATE(CCTO:001090, t0) NCI:CTCAE:10020772 NCIT:C3117 NCIT:C55060 UMLS:C0020538 UMLS:C0497247 UMLS:C1963138 UMLS:C2917273 Blood pressure, high Blood pressure, increased HTN High blood pressure Hypertension adverse event Increased blood pressure Pressure, high blood Vascular hypertensive disorder cancer_care_treatment_outcome CCTO:001090 Hypertension CCTO:001090 Blood pressure that is abnormally high. NCIT:C3117 Blood pressure, high NCIT:C3117 Blood pressure, increased NCIT:C3117 HTN NCIT:C3117 High blood pressure NCIT:C3117 Hypertension adverse event NCIT:C55060 Increased blood pressure NCIT:C3117 Pressure, high blood NCIT:C3117 Vascular hypertensive disorder NCIT:C3117 Blood pressure that is abnormally low OR A disorder characterized by a blood pressure that is below the normal expected for an individual in a given environment. CCTO:001091 implies CCTO:000049 CCTO:001091 implies CCTO:001130 CCTO:001091(time_t t0) = EVENT_STATE(CCTO:001091, t0) NCI:CTCAE:10021097 NCIT:C3128 NCIT:C55061 UMLS:C0020649 UMLS:C2917141 UMLS:C3163620 Blood pressure, decreased Blood pressure, low Decreased blood pressure Hypotension adverse event Low blood pressure Pressure, low blood Vascular hypotensive disorder cancer_care_treatment_outcome CCTO:001091 Hypotension CCTO:001091 Blood pressure that is abnormally low OR A disorder characterized by a blood pressure that is below the normal expected for an individual in a given environment. NCI:CTCAE NCIT:C3128 Blood pressure, decreased NCIT:C3128 Blood pressure, low NCIT:C3128 Decreased blood pressure NCIT:C3128 Hypotension adverse event NCIT:C55061 Low blood pressure NCIT:C3128 Pressure, low blood NCIT:C3128 Vascular hypotensive disorder NCIT:C3128 The loss of lymph into the surrounding tissue or body cavity OR A disorder characterized by the loss of lymph fluid into the surrounding tissue or body cavity. CCTO:001092 implies CCTO:000049 CCTO:001092 implies CCTO:001130 CCTO:001092(time_t t0) = EVENT_STATE(CCTO:001092, t0) NCI:CTCAE:10065773 NCIT:C78439 UMLS:C0398372 cancer_care_treatment_outcome CCTO:001092 Lymph leakage CCTO:001092 The loss of lymph into the surrounding tissue or body cavity OR A disorder characterized by the loss of lymph fluid into the surrounding tissue or body cavity. NCI:CTCAE NCIT:C78439 A disorder characterized by excessive fluid collection in tissues that causes swelling OR Excess fluid collection in tissues, causing swelling. It is the result of obstruction of lymphatic vessels or lymph nodes. CCTO:001093 implies CCTO:000049 CCTO:001093 implies CCTO:001130 CCTO:001093(time_t t0) = EVENT_STATE(CCTO:001093, t0) NCI:CTCAE:10025233 NCIT:C3207 UMLS:C0024236 cancer_care_treatment_outcome CCTO:001093 Lymphedema CCTO:001093 A disorder characterized by excessive fluid collection in tissues that causes swelling OR Excess fluid collection in tissues, causing swelling. It is the result of obstruction of lymphatic vessels or lymph nodes. NCI:CTCAE NCIT:C3207 A cystic lesion containing lymph. It usually results from injury, gynecologic surgery, or urologic surgery OR A disorder characterized by a cystic lesion containing lymph OR An adverse event characterized by a cystic lesion containing lymph. CCTO:001094 implies CCTO:000049 CCTO:001094 implies CCTO:001130 CCTO:001094(time_t t0) = EVENT_STATE(CCTO:001094, t0) NCI:CTCAE:10048642 NCIT:C55705 NCIT:C78442 UMLS:C0024248 UMLS:C1963162 Lymphocele adverse event cancer_care_treatment_outcome CCTO:001094 Lymphocele CCTO:001094 A cystic lesion containing lymph. It usually results from injury, gynecologic surgery, or urologic surgery OR A disorder characterized by a cystic lesion containing lymph OR An adverse event characterized by a cystic lesion containing lymph. NCI:CTCAE NCIT:C55705 NCIT:C78442 Lymphocele adverse event NCIT:C55705 A disorder characterized by impaired circulation to an extremity OR Deficient blood distribution to the limbs caused by narrowing or obstruction of the lumen of the peripheral arteries. CCTO:001095 implies CCTO:000049 CCTO:001095 implies CCTO:001130 CCTO:001095(time_t t0) = EVENT_STATE(CCTO:001095, t0) NCI:CTCAE:10034578 NCIT:C78535 UMLS:C0235490 cancer_care_treatment_outcome CCTO:001095 Peripheral ischemia CCTO:001095 A disorder characterized by impaired circulation to an extremity OR Deficient blood distribution to the limbs caused by narrowing or obstruction of the lumen of the peripheral arteries. NCI:CTCAE NCIT:C78535 Inflammation of a vein OR A disorder characterized by inflammation of the wall of a vein. CCTO:001096 implies CCTO:000049 CCTO:001096 implies CCTO:001130 CCTO:001096(time_t t0) = EVENT_STATE(CCTO:001096, t0) NCI:CTCAE:10034879 NCIT:C38003 UMLS:C0031542 cancer_care_treatment_outcome CCTO:001096 Phlebitis CCTO:001096 Inflammation of a vein OR A disorder characterized by inflammation of the wall of a vein. NCI:CTCAE NCIT:C38003 A disorder characterized by a blood clot and inflammation involving a superficial vein of the extremities OR Thrombosis and inflammation of a superficial vein of the extremities. Symptoms include red discoloration and warmth of the skin and pain along the affected vein. CCTO:001097 implies CCTO:000049 CCTO:001097 implies CCTO:001130 CCTO:001097(time_t t0) = EVENT_STATE(CCTO:001097, t0) NCI:CTCAE:10042554 NCIT:C78634 UMLS:C1510431 cancer_care_treatment_outcome CCTO:001097 Superficial thrombophlebitis CCTO:001097 A disorder characterized by a blood clot and inflammation involving a superficial vein of the extremities OR Thrombosis and inflammation of a superficial vein of the extremities. Symptoms include red discoloration and warmth of the skin and pain along the affected vein. NCI:CTCAE NCIT:C78634 A disorder characterized by obstruction of the blood flow in the superior vena cava. Signs and symptoms include swelling and cyanosis of the face, neck, and upper arms, cough, orthopnea and headache OR Obstruction of the blood flow in the superior vena cava caused by a malignant neoplasm, thrombosis, or aneurysm. It is a medical emergency requiring immediate treatment. Signs and symptoms include swelling and cyanosis of the face, neck, and upper arms, cough, orthopnea, and headache. CCTO:001098 implies CCTO:000049 CCTO:001098 implies CCTO:001130 CCTO:001098(time_t t0) = EVENT_STATE(CCTO:001098, t0) NCI:CTCAE:10042569 NCIT:C3396 UMLS:C0038833 cancer_care_treatment_outcome CCTO:001098 Superior vena cava syndrome CCTO:001098 A disorder characterized by obstruction of the blood flow in the superior vena cava. Signs and symptoms include swelling and cyanosis of the face, neck, and upper arms, cough, orthopnea and headache OR Obstruction of the blood flow in the superior vena cava caused by a malignant neoplasm, thrombosis, or aneurysm. It is a medical emergency requiring immediate treatment. Signs and symptoms include swelling and cyanosis of the face, neck, and upper arms, cough, orthopnea, and headache. NCI:CTCAE NCIT:C3396 Occlusion of the lumen of a vessel by a thrombus that has migrated from a distal site via the blood stream OR A disorder characterized by occlusion of a vessel by a thrombus that has migrated from a distal site via the blood stream. CCTO:001099 implies CCTO:000049 CCTO:001099 implies CCTO:001130 CCTO:001099(time_t t0) = EVENT_STATE(CCTO:001099, t0) NCI:CTCAE:10043565 NCIT:C28195 UMLS:C0040038 UMLS:C0857496 Thromboembolism cancer_care_treatment_outcome CCTO:001099 Thromboembolic event CCTO:001099 Occlusion of the lumen of a vessel by a thrombus that has migrated from a distal site via the blood stream OR A disorder characterized by occlusion of a vessel by a thrombus that has migrated from a distal site via the blood stream. NCI:CTCAE NCIT:C28195 Thromboembolism NCIT:C28195 An inflammatory process involving the wall of the vessels (large, medium, or small-sized vessels). The inflammatory process may cause necrosis or formation of granulomas in the vascular wall. It may be the result of an autoimmune disorder, infection, or malignancy. Representative examples include polyarteritis nodosa, temporal arteritis, Wegener granulomatosis, Kawasaki disease, Takayasu arteritis, and Henoch-Schonlein purpura OR A disorder characterized by inflammation involving the wall of a vessel. CCTO:001100 implies CCTO:000049 CCTO:001100 implies CCTO:001130 CCTO:001100(time_t t0) = EVENT_STATE(CCTO:001100, t0) NCI:CTCAE:10047115 NCIT:C26912 NCIT:C54741 UMLS:C0042384 UMLS:C1963274 Vasculitis adverse event cancer_care_treatment_outcome CCTO:001100 Vasculitis CCTO:001100 An inflammatory process involving the wall of the vessels (large, medium, or small-sized vessels). The inflammatory process may cause necrosis or formation of granulomas in the vascular wall. It may be the result of an autoimmune disorder, infection, or malignancy. Representative examples include polyarteritis nodosa, temporal arteritis, Wegener granulomatosis, Kawasaki disease, Takayasu arteritis, and Henoch-Schonlein purpura OR A disorder characterized by inflammation involving the wall of a vessel. NCI:CTCAE NCIT:C26912 Vasculitis adverse event NCIT:C54741 A disorder characterized by a decrease in blood supply due to narrowing or blockage of a visceral (mesenteric) artery OR Decreased blood supply to the small or large intestine due to narrowing or blockage of a visceral (mesenteric) artery. The ischemia results to the damage of the intestinal tissues. It may be chronic, caused by atherosclerosis or acute, secondary to the formation of a thrombus or embolus in the mesenteric arterial lumen. In chronic ischemia, patients present with abdominal pain manifested in a short time after a meal and weight loss. In acute ischemia, patients present with sudden and acute abdominal pain, nausea and vomiting, and blood in the stool. CCTO:001101 implies CCTO:000049 CCTO:001101 implies CCTO:001130 CCTO:001101(time_t t0) = EVENT_STATE(CCTO:001101, t0) NCI:CTCAE:10054692 NCIT:C78712 UMLS:C0853812 Mesenteric artery ischemia Visceral artery ischemia cancer_care_treatment_outcome CCTO:001101 Visceral arterial ischemia CCTO:001101 A disorder characterized by a decrease in blood supply due to narrowing or blockage of a visceral (mesenteric) artery OR Decreased blood supply to the small or large intestine due to narrowing or blockage of a visceral (mesenteric) artery. The ischemia results to the damage of the intestinal tissues. It may be chronic, caused by atherosclerosis or acute, secondary to the formation of a thrombus or embolus in the mesenteric arterial lumen. In chronic ischemia, patients present with abdominal pain manifested in a short time after a meal and weight loss. In acute ischemia, patients present with sudden and acute abdominal pain, nausea and vomiting, and blood in the stool. NCI:CTCAE NCIT:C78712 Mesenteric artery ischemia NCIT:C78712 Visceral artery ischemia NCIT:C78712 CCTO:001102 implies CCTO:000114 cancer_care_treatment_outcome CCTO:001102 Disease-specific death CCTO:001102 cancer_care_treatment_outcome CCTO:001103 General disorders and administration site conditions CCTO:001103 CCTO:001104 implies CCTO:000057 CCTO:001104 implies CCTO:000087 CCTO:001104 implies CCTO:001131 CCTO:001104 implies NOT CCTO:001133 cancer_care_treatment_outcome CCTO:001104 Regional recurrence CCTO:001104 UMLS:C0004936 cancer_care_treatment_outcome CCTO:001105 Psychiatric disorders CCTO:001105 CCTO:001106 implies CCTO:000114 cancer_care_treatment_outcome CCTO:001106 Prostate cancer-specific death CCTO:001106 cancer_care_treatment_outcome Biochemical disease CCTO:001107 Tumor marker increased CCTO:001107 UMLS:C0017178 cancer_care_treatment_outcome CCTO:001108 Gastrointestinal disorders CCTO:001108 UMLS:C0263660 cancer_care_treatment_outcome CCTO:001109 Musculoskeletal and connective tissue disorders CCTO:001109 CCTO:001110 implies CCTO:000114 cancer_care_treatment_outcome CCTO:001110 Breast cancer specific death CCTO:001110 cancer_care_treatment_outcome CCTO:001111 Biological progression CCTO:001111 UMLS:C0851353 cancer_care_treatment_outcome CCTO:001112 Blood and lymphatic system disorders CCTO:001112 UMLS:C0018799 cancer_care_treatment_outcome CCTO:001113 Cardiac disorders CCTO:001113 UMLS:C0851354 cancer_care_treatment_outcome CCTO:001114 Ear and labyrinth disorders CCTO:001114 UMLS:C0014130 cancer_care_treatment_outcome CCTO:001115 Endocrine disorders CCTO:001115 UMLS:C0015397 cancer_care_treatment_outcome CCTO:001116 Eye disorders CCTO:001116 UMLS:C0267792 cancer_care_treatment_outcome CCTO:001117 Hepatobiliary disorders CCTO:001117 cancer_care_treatment_outcome CCTO:001118 Immune system disorders CCTO:001118 cancer_care_treatment_outcome CCTO:001119 Infections and infestations CCTO:001119 CCTO:001120 implies CCTO:000043 cancer_care_treatment_outcome CCTO:001120 Injury, poisoning and procedural complications CCTO:001120 UMLS:C0851358 cancer_care_treatment_outcome CCTO:001121 Metabolism and nutrition disorders CCTO:001121 cancer_care_treatment_outcome CCTO:001122 Neoplasms benign, malignant and unspecified (incl cysts and polyps) CCTO:001122 UMLS:C0027765 cancer_care_treatment_outcome CCTO:001123 Nervous system disorders CCTO:001123 UMLS:C0851363 cancer_care_treatment_outcome CCTO:001124 Pregnancy, puerperium and perinatal conditions CCTO:001124 cancer_care_treatment_outcome CCTO:001125 Renal and urinary disorders CCTO:001125 cancer_care_treatment_outcome CCTO:001126 Reproductive system and breast disorders CCTO:001126 UMLS:C0851355 cancer_care_treatment_outcome CCTO:001127 Respiratory, thoracic and mediastinal disorders CCTO:001127 UMLS:C0178298 cancer_care_treatment_outcome CCTO:001128 Skin and subcutaneous tissue disorders CCTO:001128 UMLS:C0851364 cancer_care_treatment_outcome CCTO:001129 Social circumstances CCTO:001129 UMLS:C0042373 cancer_care_treatment_outcome CCTO:001130 Vascular disorders CCTO:001130 CCTO:001131 implies CCTO:000211 CCTO:001131 implies NOT CCTO:000171 cancer_care_treatment_outcome CCTO:001131 Locoregional recurrence CCTO:001131 UMLS:C0003188 cancer_care_treatment_outcome CCTO:001132 Anthropometry CCTO:001132 CCTO:001133 implies NOT CCTO:001104 cancer_care_treatment_outcome Regional tumor control CCTO:001133 Regional control CCTO:001133 releases/2018-05-11 The concept has value type X cancer_care_treatment_outcome Has value type CCTO:000008 has_value_type CCTO:000008 The concept is assessed by X cancer_care_treatment_outcome Is assessed by CCTO:000009 is_assessed_by CCTO:000009 The concept is opposite of X cancer_care_treatment_outcome Is opposite of CCTO:000010 is_opposite_of CCTO:000010 The concept is timed observation of X cancer_care_treatment_outcome Is timed observation of CCTO:000011 is_timed_observation_of CCTO:000011 The concept is duration of X cancer_care_treatment_outcome Is duration of CCTO:000012 is_duration_of CCTO:000012 The concept is probability of X cancer_care_treatment_outcome Is probability of CCTO:000013 is_probability_of CCTO:000013 Erick Antezana Frank Lin Richard Epstein Simon Kocbek Tudor Groza Creative Commons CC-BY 4.0 Creative Commons CC-BY 4.0 An ontology for cancer care (treatment outcome) in solid tumours 05:11:0018 00:00 cancer_care_treatment_outcome 1.4 Frank Po-Yen Lin