Adrien Barton Arnaud Rosier Jean-François Ethier Paul Fabry http://creativecommons.org/licenses/by/4.0/ Cardio Vascular Disease Ontology CVDO is an ontology of cardiovascular diseases structured on OBO foundry’s principle and based on BFO. CVDO reorganizes and completes DOID cardiovascular diseases following OGMS tripartite model of disease, and builds its taxonomy of diseases largely by automatic reasoning. 2024-05-17 Relates an entity in the ontology to the name of the variable that is used to represent it in the code that generates the BFO OWL file from the lispy specification. Really of interest to developers only BFO OWL specification label Relates an entity in the ontology to the term that is used to represent it in the the CLIF specification of BFO2 Person:Alan Ruttenberg Really of interest to developers only BFO CLIF specification label This annotation property is created temporarily for better visibility of the distinction between DOID definitions and updated CVDO definition (when a DOID definition of a class did not need to be changed, no additional CVDO definition was included). Ultimately, 'CVDO definition' annotation properties should be replaced by 'definition' annotation properties. CVDO definition This annotation property is created temporarily for better visibility of the CVDO notes, in particular those that concern DOID classes. Ultimately, 'CVDO editor note' annotation properties should be replaced by 'editor note' annotation properties, or removed. CVDO editor note editor preferred term The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English) PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> editor preferred term example of usage has curation status PERSON:Alan Ruttenberg PERSON:Bill Bug PERSON:Melanie Courtot OBI_0000281 has curation status definition The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions. PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> definition definition editor note An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology. PERSON:Daniel Schober GROUP:OBI:<http://purl.obfoundry.org/obo/obi> editor note editor note definition editor Name of editor entering the definition in the file. The definition editor is a point of contact for information regarding the term. The definition editor may be, but is not always, the author of the definition, which may have been worked upon by several people PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> definition editor definition editor term editor alternative term definition source formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007 PERSON:Daniel Schober Discussion on obo-discuss mailing-list, see http://bit.ly/hgm99w GROUP:OBI:<http://purl.obolibrary.org/obo/obi> definition source definition source curator note An administrative note of use for a curator but of no use for a user PERSON:Alan Ruttenberg curator note curator note imported from elucidation has associated axiom(nl) has associated axiom(fol) has axiom label gram-positive bacterial infectious disease subset_property has_alternative_id database_cross_reference has_exact_synonym has_obo_namespace has_related_synonym in_subset inheres-in_at inheresInAt b inheres_in c at t =Def. b is a dependent continuant & c is an independent continuant that is not a spatial region & b s-depends_on c at t. (axiom label in BFO2 Reference: [051-002]) Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'inheres in at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'inheres in@en(x,y,t)'. BFO 2 Reference: Inherence is a subrelation of s-depends_on which holds between a dependent continuant and an independent continuant that is not a spatial region. Since dependent continuants cannot migrate from one independent continuant bearer to another, it follows that if b s-depends_on independent continuant c at some time, then b s-depends_on c at all times at which a exists. Inherence is in this sense redundantly time-indexed.For example, consider the particular instance of openness inhering in my mouth at t as I prepare to take a bite out of a donut, followed by a closedness at t+1 when I bite the donut and start chewing. The openness instance is then shortlived, and to say that it s-depends_on my mouth at all times at which this openness exists, means: at all times during this short life. Every time you make a fist, you make a new (instance of the universal) fist. (Every time your hand has the fist-shaped quality, there is created a new instance of the universal fist-shaped quality.) BFO2 Reference: independent continuant that is not a spatial region BFO2 Reference: specifically dependent continuant (iff (inheresInAt a b t) (and (DependentContinuant a) (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))) // axiom label in BFO2 CLIF: [051-002] inheres in at all times b inheres_in c at t =Def. b is a dependent continuant & c is an independent continuant that is not a spatial region & b s-depends_on c at t. (axiom label in BFO2 Reference: [051-002]) (iff (inheresInAt a b t) (and (DependentContinuant a) (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))) // axiom label in BFO2 CLIF: [051-002] bearer-of_st bearerOfAt b bearer_of c at t =Def. c s-depends_on b at t & b is an independent continuant that is not a spatial region. (axiom label in BFO2 Reference: [053-004]) Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'bearer of at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'bearer of@en'(x,y,t) BFO2 Reference: independent continuant that is not a spatial region BFO2 Reference: specifically dependent continuant (iff (bearerOfAt a b t) (and (specificallyDependsOnAt b a t) (IndependentContinuant a) (not (SpatialRegion a)) (existsAt b t))) // axiom label in BFO2 CLIF: [053-004] bearer of at some time b bearer_of c at t =Def. c s-depends_on b at t & b is an independent continuant that is not a spatial region. (axiom label in BFO2 Reference: [053-004]) (iff (bearerOfAt a b t) (and (specificallyDependsOnAt b a t) (IndependentContinuant a) (not (SpatialRegion a)) (existsAt b t))) // axiom label in BFO2 CLIF: [053-004] realizes realizes to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003]) (forall (x y t) (if (realizesAt x y t) (and (Process x) (or (Disposition y) (Role y)) (exists (z) (and (MaterialEntity z) (hasParticipantAt x z t) (bearerOfAt z y t)))))) // axiom label in BFO2 CLIF: [059-003] realizes to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003]) (forall (x y t) (if (realizesAt x y t) (and (Process x) (or (Disposition y) (Role y)) (exists (z) (and (MaterialEntity z) (hasParticipantAt x z t) (bearerOfAt z y t)))))) // axiom label in BFO2 CLIF: [059-003] participates-in_st participatesInAt [copied from inverse property 'has participant at some time'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'has participant at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'has participant@en'(x,y,t) [copied from inverse property 'has participant at some time'] BFO 2 Reference: Spatial regions do not participate in processes. [copied from inverse property 'has participant at some time'] BFO2 Reference: independent continuant that is not a spatial region, specifically dependent continuant, generically dependent continuant [copied from inverse property 'has participant at some time'] BFO2 Reference: process [copied from inverse property 'has participant at some time'] has_participant is an instance-level relation between a process, a continuant, and a temporal region at which the continuant participates in some way in the process. (axiom label in BFO2 Reference: [086-003]) participates in at some time has-participant_st hasParticipantAt Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'has participant at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'has participant@en'(x,y,t) BFO 2 Reference: Spatial regions do not participate in processes. BFO2 Reference: independent continuant that is not a spatial region, specifically dependent continuant, generically dependent continuant BFO2 Reference: process has_participant is an instance-level relation between a process, a continuant, and a temporal region at which the continuant participates in some way in the process. (axiom label in BFO2 Reference: [086-003]) if b has_participant c at t & c is a generically dependent continuant, then there is some independent continuant that is not a spatial region d, and which is such that c g-depends on d at t & b s-depends_on d at t. (axiom label in BFO2 Reference: [091-003]) if b has_participant c at t & c is a specifically dependent continuant, then there is some independent continuant that is not a spatial region d, c s-depends_on d at t & b s-depends_on d at t. (axiom label in BFO2 Reference: [090-003]) if b has_participant c at t then b is an occurrent. (axiom label in BFO2 Reference: [087-001]) if b has_participant c at t then c exists at t. (axiom label in BFO2 Reference: [089-001]) if b has_participant c at t then c is a continuant. (axiom label in BFO2 Reference: [088-001]) (forall (x y t) (if (and (hasParticipantAt x y t) (GenericallyDependentContinuant y)) (exists (z) (and (IndependentContinuant z) (not (SpatialRegion z)) (genericallyDependsOn y z t) (specificallyDependsOnAt x z t))))) // axiom label in BFO2 CLIF: [091-003] (forall (x y t) (if (and (hasParticipantAt x y t) (SpecificallyDependentContinuant y)) (exists (z) (and (IndependentContinuant z) (not (SpatialRegion z)) (specificallyDependsOnAt x z t) (specificallyDependsOnAt y z t))))) // axiom label in BFO2 CLIF: [090-003] (forall (x y t) (if (hasParticipantAt x y t) (Continuant y))) // axiom label in BFO2 CLIF: [088-001] (forall (x y t) (if (hasParticipantAt x y t) (Occurrent x))) // axiom label in BFO2 CLIF: [087-001] (forall (x y t) (if (hasParticipantAt x y t) (existsAt y t))) // axiom label in BFO2 CLIF: [089-001] has participant at some time has_participant is an instance-level relation between a process, a continuant, and a temporal region at which the continuant participates in some way in the process. (axiom label in BFO2 Reference: [086-003]) if b has_participant c at t & c is a generically dependent continuant, then there is some independent continuant that is not a spatial region d, and which is such that c g-depends on d at t & b s-depends_on d at t. (axiom label in BFO2 Reference: [091-003]) if b has_participant c at t & c is a specifically dependent continuant, then there is some independent continuant that is not a spatial region d, c s-depends_on d at t & b s-depends_on d at t. (axiom label in BFO2 Reference: [090-003]) if b has_participant c at t then b is an occurrent. (axiom label in BFO2 Reference: [087-001]) if b has_participant c at t then c exists at t. (axiom label in BFO2 Reference: [089-001]) if b has_participant c at t then c is a continuant. (axiom label in BFO2 Reference: [088-001]) (forall (x y t) (if (and (hasParticipantAt x y t) (GenericallyDependentContinuant y)) (exists (z) (and (IndependentContinuant z) (not (SpatialRegion z)) (genericallyDependsOn y z t) (specificallyDependsOnAt x z t))))) // axiom label in BFO2 CLIF: [091-003] (forall (x y t) (if (and (hasParticipantAt x y t) (SpecificallyDependentContinuant y)) (exists (z) (and (IndependentContinuant z) (not (SpatialRegion z)) (specificallyDependsOnAt x z t) (specificallyDependsOnAt y z t))))) // axiom label in BFO2 CLIF: [090-003] (forall (x y t) (if (hasParticipantAt x y t) (Continuant y))) // axiom label in BFO2 CLIF: [088-001] (forall (x y t) (if (hasParticipantAt x y t) (Occurrent x))) // axiom label in BFO2 CLIF: [087-001] (forall (x y t) (if (hasParticipantAt x y t) (existsAt y t))) // axiom label in BFO2 CLIF: [089-001] concretizes_st concretizesAt You may concretize a piece of software by installing it in your computer You may concretize a recipe that you find in a cookbook by turning it into a plan which exists as a realizable dependent continuant in your head. you may concretize a poem as a pattern of memory traces in your head Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'concretizes at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'concretizes@en'(x,y,t) b concretizes c at t means: b is a specifically dependent continuant & c is a generically dependent continuant & for some independent continuant that is not a spatial region d, b s-depends_on d at t & c g-depends on d at t & if c migrates from bearer d to another bearer e than a copy of b will be created in e. (axiom label in BFO2 Reference: [075-002]) if b g-depends on c at some time t, then there is some d, such that d concretizes b at t and d s-depends_on c at t. (axiom label in BFO2 Reference: [076-001]) (forall (x y t) (if (concretizesAt x y t) (and (SpecificallyDependentContinuant x) (GenericallyDependentContinuant y) (exists (z) (and (IndependentContinuant z) (specificallyDependsOnAt x z t) (genericallyDependsOnAt y z t)))))) // axiom label in BFO2 CLIF: [075-002] (forall (x y t) (if (genericallyDependsOnAt x y t) (exists (z) (and (concretizesAt z x t) (specificallyDependsOnAt z y t))))) // axiom label in BFO2 CLIF: [076-001] concretizes at some time b concretizes c at t means: b is a specifically dependent continuant & c is a generically dependent continuant & for some independent continuant that is not a spatial region d, b s-depends_on d at t & c g-depends on d at t & if c migrates from bearer d to another bearer e than a copy of b will be created in e. (axiom label in BFO2 Reference: [075-002]) if b g-depends on c at some time t, then there is some d, such that d concretizes b at t and d s-depends_on c at t. (axiom label in BFO2 Reference: [076-001]) (forall (x y t) (if (concretizesAt x y t) (and (SpecificallyDependentContinuant x) (GenericallyDependentContinuant y) (exists (z) (and (IndependentContinuant z) (specificallyDependsOnAt x z t) (genericallyDependsOnAt y z t)))))) // axiom label in BFO2 CLIF: [075-002] (forall (x y t) (if (genericallyDependsOnAt x y t) (exists (z) (and (concretizesAt z x t) (specificallyDependsOnAt z y t))))) // axiom label in BFO2 CLIF: [076-001] contains-process containsProcess [copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t [XXX-001 contains process s-depends-on_at specificallyDependsOn A pain s-depends_on the organism that is experiencing the pain a gait s-depends_on the walking object. (All at some specific time.) a shape s-depends_on the shaped object one-sided s-dependence of a dependent continuant on an independent continuant: an instance of headache s-depends_on some head one-sided s-dependence of a dependent continuant on an independent continuant: an instance of temperature s-depends_on some organism one-sided s-dependence of a process on something: a process of cell death s-depends_on a cell one-sided s-dependence of a process on something: an instance of seeing (a relational process) s-depends_on some organism and on some seen entity, which may be an occurrent or a continuant one-sided s-dependence of one occurrent on another: a process of answering a question is dependent on a prior process of asking a question one-sided s-dependence of one occurrent on another: a process of obeying a command is dependent on a prior process of issuing a command one-sided s-dependence of one occurrent on multiple independent continuants: a relational process of hitting a ball with a cricket bat one-sided s-dependence of one occurrent on multiple independent continuants: a relational process of paying cash to a merchant in exchange for a bag of figs reciprocal s-dependence between occurrents: a process of buying and the associated process of selling reciprocal s-dependence between occurrents: a process of increasing the volume of a portion of gas while temperature remains constant and the associated process of decreasing the pressure exerted by the gas reciprocal s-dependence between occurrents: in a game of chess the process of playing with the white pieces is mutually dependent on the process of playing with the black pieces the one-sided dependence of an occurrent on an independent continuant: football match on the players, the ground, the ball the one-sided dependence of an occurrent on an independent continuant: handwave on a hand the three-sided reciprocal s-dependence of the hue, saturation and brightness of a color [45 the three-sided reciprocal s-dependence of the pitch, timbre and volume of a tone [45 the two-sided reciprocal s-dependence of the roles of husband and wife [20 Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'specifically depends on at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'specifically depends on@en(x,y,t)'. BFO 2 Reference: An entity – for example an act of communication or a game of football – can s-depends_on more than one entity. Complex phenomena for example in the psychological and social realms (such as inferring, commanding and requesting) or in the realm of multi-organismal biological processes (such as infection and resistance), will involve multiple families of dependence relations, involving both continuants and occurrents [1, 4, 28 BFO 2 Reference: S-dependence is just one type of dependence among many; it is what, in the literature, is referred to as ‘existential dependence’ [87, 46, 65, 20 BFO 2 Reference: the relation of s-depends_on does not in every case require simultaneous existence of its relata. Note the difference between such cases and the cases of continuant universals defined historically: the act of answering depends existentially on the prior act of questioning; the human being who was baptized or who answered a question does not himself depend existentially on the prior act of baptism or answering. He would still exist even if these acts had never taken place. BFO2 Reference: specifically dependent continuant\; process; process boundary To say that b s-depends_on a at t is to say that b and c do not share common parts & b is of its nature such that it cannot exist unless c exists & b is not a boundary of c and b is not a site of which c is the host [64 If b is s-depends_on something at some time, then b is not a material entity. (axiom label in BFO2 Reference: [052-001]) If b s-depends_on something at t, then there is some c, which is an independent continuant and not a spatial region, such that b s-depends_on c at t. (axiom label in BFO2 Reference: [136-001]) If occurrent b s-depends_on some independent continuant c at t, then b s-depends_on c at every time at which b exists. (axiom label in BFO2 Reference: [015-002]) an entity does not s-depend_on any of its (continuant or occurrent) parts or on anything it is part of. (axiom label in BFO2 Reference: [013-002]) if b s-depends_on c at t & c s-depends_on d at t then b s-depends_on d at t. (axiom label in BFO2 Reference: [054-002]) (forall (x y t) (if (and (Entity x) (or (continuantPartOfAt y x t) (continuantPartOfAt x y t) (occurrentPartOf x y) (occurrentPartOf y x))) (not (specificallyDependsOnAt x y t)))) // axiom label in BFO2 CLIF: [013-002] (forall (x y t) (if (and (Occurrent x) (IndependentContinuant y) (specificallyDependsOnAt x y t)) (forall (t_1) (if (existsAt x t_1) (specificallyDependsOnAt x y t_1))))) // axiom label in BFO2 CLIF: [015-002] (forall (x y t) (if (specificallyDependsOnAt x y t) (exists (z) (and (IndependentContinuant z) (not (SpatialRegion z)) (specificallyDependsOnAt x z t))))) // axiom label in BFO2 CLIF: [136-001] (forall (x y z t) (if (and (specificallyDependsOnAt x y t) (specificallyDependsOnAt y z t)) (specificallyDependsOnAt x z t))) // axiom label in BFO2 CLIF: [054-002] (forall (x) (if (exists (y t) (specificallyDependsOnAt x y t)) (not (MaterialEntity x)))) // axiom label in BFO2 CLIF: [052-001] specifically depends on at all times If b is s-depends_on something at some time, then b is not a material entity. (axiom label in BFO2 Reference: [052-001]) If b s-depends_on something at t, then there is some c, which is an independent continuant and not a spatial region, such that b s-depends_on c at t. (axiom label in BFO2 Reference: [136-001]) If occurrent b s-depends_on some independent continuant c at t, then b s-depends_on c at every time at which b exists. (axiom label in BFO2 Reference: [015-002]) an entity does not s-depend_on any of its (continuant or occurrent) parts or on anything it is part of. (axiom label in BFO2 Reference: [013-002]) if b s-depends_on c at t & c s-depends_on d at t then b s-depends_on d at t. (axiom label in BFO2 Reference: [054-002]) (forall (x y t) (if (and (Entity x) (or (continuantPartOfAt y x t) (continuantPartOfAt x y t) (occurrentPartOf x y) (occurrentPartOf y x))) (not (specificallyDependsOnAt x y t)))) // axiom label in BFO2 CLIF: [013-002] (forall (x y t) (if (and (Occurrent x) (IndependentContinuant y) (specificallyDependsOnAt x y t)) (forall (t_1) (if (existsAt x t_1) (specificallyDependsOnAt x y t_1))))) // axiom label in BFO2 CLIF: [015-002] (forall (x y t) (if (specificallyDependsOnAt x y t) (exists (z) (and (IndependentContinuant z) (not (SpatialRegion z)) (specificallyDependsOnAt x z t))))) // axiom label in BFO2 CLIF: [136-001] (forall (x y z t) (if (and (specificallyDependsOnAt x y t) (specificallyDependsOnAt y z t)) (specificallyDependsOnAt x z t))) // axiom label in BFO2 CLIF: [054-002] (forall (x) (if (exists (y t) (specificallyDependsOnAt x y t)) (not (MaterialEntity x)))) // axiom label in BFO2 CLIF: [052-001] f-of_at functionOfAt a function_of b at t =Def. a is a function and a inheres_in b at t. (axiom label in BFO2 Reference: [067-001]) Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'function of at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'function of@en(x,y,t)'. (iff (functionOf a b t) (and (Function a) (inheresInAt a b t))) // axiom label in BFO2 CLIF: [067-001] function of at all times a function_of b at t =Def. a is a function and a inheres_in b at t. (axiom label in BFO2 Reference: [067-001]) (iff (functionOf a b t) (and (Function a) (inheresInAt a b t))) // axiom label in BFO2 CLIF: [067-001] q-of_at qualityOfAt b quality_of c at t = Def. b is a quality & c is an independent continuant that is not a spatial region & b s-depends_on c at t. (axiom label in BFO2 Reference: [056-002]) Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'quality of at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'quality of@en(x,y,t)'. (iff (qualityOfAt a b t) (and (Quality a) (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))) // axiom label in BFO2 CLIF: [056-002] quality of at all times b quality_of c at t = Def. b is a quality & c is an independent continuant that is not a spatial region & b s-depends_on c at t. (axiom label in BFO2 Reference: [056-002]) (iff (qualityOfAt a b t) (and (Quality a) (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))) // axiom label in BFO2 CLIF: [056-002] r-of_at roleOfAt a role_of b at t =Def. a is a role and a inheres_in b at t. (axiom label in BFO2 Reference: [065-001]) Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'role of at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'role of@en(x,y,t)'. (iff (roleOfAt a b t) (and (Role a) (inheresInAt a b t))) // axiom label in BFO2 CLIF: [065-001] role of at all times a role_of b at t =Def. a is a role and a inheres_in b at t. (axiom label in BFO2 Reference: [065-001]) (iff (roleOfAt a b t) (and (Role a) (inheresInAt a b t))) // axiom label in BFO2 CLIF: [065-001] g-depends-on_st genericallyDependsOn Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'generically depends on at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'generically depends on@en'(x,y,t) BFO2 Reference: generically dependent continuant BFO2 Reference: independent continuant b g-depends on c at t1 means: b exists at t1 and c exists at t1 & for some type B it holds that (c instantiates B at t1) & necessarily, for all t (if b exists at t then some instance_of B exists at t) & not (b s-depends_on c at t1). (axiom label in BFO2 Reference: [072-002]) if b g-depends_on c at some time t, then b g-depends_on something at all times at which b exists. (axiom label in BFO2 Reference: [073-001]) (forall (x y) (if (exists (t) (genericallyDependsOnAt x y t)) (forall (t_1) (if (existsAt x t_1) (exists (z) (genericallyDependsOnAt x z t_1)))))) // axiom label in BFO2 CLIF: [073-001] generically depends on at some time b g-depends on c at t1 means: b exists at t1 and c exists at t1 & for some type B it holds that (c instantiates B at t1) & necessarily, for all t (if b exists at t then some instance_of B exists at t) & not (b s-depends_on c at t1). (axiom label in BFO2 Reference: [072-002]) if b g-depends_on c at some time t, then b g-depends_on something at all times at which b exists. (axiom label in BFO2 Reference: [073-001]) (forall (x y) (if (exists (t) (genericallyDependsOnAt x y t)) (forall (t_1) (if (existsAt x t_1) (exists (z) (genericallyDependsOnAt x z t_1)))))) // axiom label in BFO2 CLIF: [073-001] has-f_st hasFunctionAt a has_function b at t =Def. b function_of a at t. (axiom label in BFO2 Reference: [070-001]) Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'has function at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'has function@en'(x,y,t) (iff (hasFunctionAt a b t) (functionOf b a t)) // axiom label in BFO2 CLIF: [070-001] has function at some time a has_function b at t =Def. b function_of a at t. (axiom label in BFO2 Reference: [070-001]) (iff (hasFunctionAt a b t) (functionOf b a t)) // axiom label in BFO2 CLIF: [070-001] has-q_st has quality at some time has-r_st hasRoleAt a has_role b at t =Def. b role_of a at t. (axiom label in BFO2 Reference: [068-001]) Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'has role at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'has role@en'(x,y,t) (iff (hasRoleAt a b t) (roleOfAt b a t)) // axiom label in BFO2 CLIF: [068-001] has role at some time a has_role b at t =Def. b role_of a at t. (axiom label in BFO2 Reference: [068-001]) (iff (hasRoleAt a b t) (roleOfAt b a t)) // axiom label in BFO2 CLIF: [068-001] has-g-dep_st [copied from inverse property 'generically depends on at some time'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'generically depends on at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'generically depends on@en'(x,y,t) [copied from inverse property 'generically depends on at some time'] BFO2 Reference: generically dependent continuant [copied from inverse property 'generically depends on at some time'] BFO2 Reference: independent continuant [copied from inverse property 'generically depends on at some time'] b g-depends on c at t1 means: b exists at t1 and c exists at t1 & for some type B it holds that (c instantiates B at t1) & necessarily, for all t (if b exists at t then some instance_of B exists at t) & not (b s-depends_on c at t1). (axiom label in BFO2 Reference: [072-002]) has generic dependent at some time d-of_at dispositionOfAt a disposition_of b at t =Def. a is a disposition and a inheres_in b at t. (axiom label in BFO2 Reference: [066-001]) Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'disposition of at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'disposition of@en(x,y,t)'. (iff (dispositionOf a b t) (and (Disposition a) (inheresInAt a b t))) // axiom label in BFO2 CLIF: [066-001] disposition of at all times a disposition_of b at t =Def. a is a disposition and a inheres_in b at t. (axiom label in BFO2 Reference: [066-001]) (iff (dispositionOf a b t) (and (Disposition a) (inheresInAt a b t))) // axiom label in BFO2 CLIF: [066-001] c-has-part_at hasContinuantPartAt [copied from inverse property 'part of continuant at all times that whole exists'] forall(t) exists_at(y,t) -> exists_at(x,t) and 'part of continuant'(x,y,t) b has_continuant_part c at t = Def. c continuant_part_of b at t. (axiom label in BFO2 Reference: [006-001]) Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'has continuant part at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'has continuant part@en(x,y,t)'. [copied from inverse property 'part of continuant at all times that whole exists'] This is a binary version of a ternary time-indexed, instance level, relation. Unlike the rest of the temporalized relations which temporally quantify over existence of the subject of the relation, this relation temporally quantifies over the existence of the object of the relation. The relation is provided tentatively, to assess whether the GO needs such a relation. It is inverse of 'has continuant part at all times' (iff (hasContinuantPartAt a b t) (continuantPartOfAt b a t)) // axiom label in BFO2 CLIF: [006-001] has continuant part at all times b has_continuant_part c at t = Def. c continuant_part_of b at t. (axiom label in BFO2 Reference: [006-001]) (iff (hasContinuantPartAt a b t) (continuantPartOfAt b a t)) // axiom label in BFO2 CLIF: [006-001] c-has-ppart_at hasProperContinuantPartAt b has_proper_continuant_part c at t = Def. c proper_continuant_part_of b at t. [XXX-001 Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'has proper continuant part at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'has proper continuant part@en(x,y,t)'. has proper continuant part at all times has-d_st hasDispositionAt a has_disposition b at t =Def. b disposition_of a at t. (axiom label in BFO2 Reference: [069-001]) Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'has disposition at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'has disposition@en'(x,y,t) (iff (hasDispositionAt a b t) (dispositionOf b a t)) // axiom label in BFO2 CLIF: [069-001] has disposition at some time a has_disposition b at t =Def. b disposition_of a at t. (axiom label in BFO2 Reference: [069-001]) (iff (hasDispositionAt a b t) (dispositionOf b a t)) // axiom label in BFO2 CLIF: [069-001] has-member-part_st [copied from inverse property 'member part of at some time'] each piece in a chess set is a member part of the chess set; each Beatle in the collection called The Beatles is a member part of The Beatles. [copied from inverse property 'member part of at some time'] each tree in a forest is a member_part of the forest [copied from inverse property 'member part of at some time'] b member_part_of c at t =Def. b is an object & there is at t a mutually exhaustive and pairwise disjoint partition of c into objects x1, …, xn (for some n &gt; 1) with b = xi for some 1 ? i ? n. (axiom label in BFO2 Reference: [026-004]) [copied from inverse property 'member part of at some time'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'member part of at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'member part of@en'(x,y,t) [copied from inverse property 'member part of at some time'] BFO2 Reference: object [copied from inverse property 'member part of at some time'] BFO2 Reference: object aggregate has member part at some time o-has-ppart hasProperOccurrentPart [copied from inverse property 'proper part of occurrent'] b proper_occurrent_part_of c =Def. b occurrent_part_of c & b and c are not identical. (axiom label in BFO2 Reference: [005-001]) b has_proper_occurrent_part c = Def. c proper_occurrent_part_of b. [XXX-001 has proper occurrent part has-profile has profile has-t-part [copied from inverse property 'temporal part of'] the 4th year of your life is a temporal part of your life\. The first quarter of a game of football is a temporal part of the whole game\. The process of your heart beating from 4pm to 5pm today is a temporal part of the entire process of your heart beating.\ The 4th year of your life is a temporal part of your life [copied from inverse property 'temporal part of'] the process boundary which separates the 3rd and 4th years of your life. [copied from inverse property 'temporal part of'] your heart beating from 4pm to 5pm today is a temporal part of the process of your heart beating [copied from inverse property 'temporal part of'] b proper_temporal_part_of c =Def. b temporal_part_of c & not (b = c). (axiom label in BFO2 Reference: [116-001]) [copied from inverse property 'temporal part of'] b temporal_part_of c =Def.b occurrent_part_of c & & for some temporal region t, b occupies_temporal_region t & for all occurrents d, t (if d occupies_temporal_region t & t? occurrent_part_of t then (d occurrent_part_of a iff d occurrent_part_of b)). (axiom label in BFO2 Reference: [078-003]) has temporal part r-location-of_st [copied from inverse property 'occupies spatial region at some time'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'occupies spatial region at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'occupies spatial region@en'(x,y,t) [copied from inverse property 'occupies spatial region at some time'] BFO2 Reference: independent continuant [copied from inverse property 'occupies spatial region at some time'] BFO2 Reference: spatial region [copied from inverse property 'occupies spatial region at some time'] b occupies_spatial_region r at t means that r is a spatial region in which independent continuant b is exactly located (axiom label in BFO2 Reference: [041-002]) has spatial occupant at some time has-location_st [copied from inverse property 'located in at some time'] Mary located_in Salzburg [copied from inverse property 'located in at some time'] the Empire State Building located_in New York. [copied from inverse property 'located in at some time'] this portion of cocaine located_in this portion of blood [copied from inverse property 'located in at some time'] this stem cell located_in this portion of bone marrow [copied from inverse property 'located in at some time'] your arm located_in your body [copied from inverse property 'located in at some time'] b located_in c at t = Def. b and c are independent continuants, and the region at which b is located at t is a (proper or improper) continuant_part_of the region at which c is located at t. (axiom label in BFO2 Reference: [045-001]) [copied from inverse property 'located in at some time'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'located in at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'located in@en'(x,y,t) [copied from inverse property 'located in at some time'] BFO2 Reference: independent continuant has location at some time has-s-dep_st [copied from inverse property 'specifically depends on at some time'] A pain s-depends_on the organism that is experiencing the pain [copied from inverse property 'specifically depends on at some time'] a gait s-depends_on the walking object. (All at some specific time.) [copied from inverse property 'specifically depends on at some time'] a shape s-depends_on the shaped object [copied from inverse property 'specifically depends on at some time'] one-sided s-dependence of a dependent continuant on an independent continuant: an instance of headache s-depends_on some head [copied from inverse property 'specifically depends on at some time'] one-sided s-dependence of a dependent continuant on an independent continuant: an instance of temperature s-depends_on some organism [copied from inverse property 'specifically depends on at some time'] one-sided s-dependence of a process on something: a process of cell death s-depends_on a cell [copied from inverse property 'specifically depends on at some time'] one-sided s-dependence of a process on something: an instance of seeing (a relational process) s-depends_on some organism and on some seen entity, which may be an occurrent or a continuant [copied from inverse property 'specifically depends on at some time'] one-sided s-dependence of one occurrent on another: a process of answering a question is dependent on a prior process of asking a question [copied from inverse property 'specifically depends on at some time'] one-sided s-dependence of one occurrent on another: a process of obeying a command is dependent on a prior process of issuing a command [copied from inverse property 'specifically depends on at some time'] one-sided s-dependence of one occurrent on multiple independent continuants: a relational process of hitting a ball with a cricket bat [copied from inverse property 'specifically depends on at some time'] one-sided s-dependence of one occurrent on multiple independent continuants: a relational process of paying cash to a merchant in exchange for a bag of figs [copied from inverse property 'specifically depends on at some time'] reciprocal s-dependence between occurrents: a process of buying and the associated process of selling [copied from inverse property 'specifically depends on at some time'] reciprocal s-dependence between occurrents: a process of increasing the volume of a portion of gas while temperature remains constant and the associated process of decreasing the pressure exerted by the gas [copied from inverse property 'specifically depends on at some time'] reciprocal s-dependence between occurrents: in a game of chess the process of playing with the white pieces is mutually dependent on the process of playing with the black pieces [copied from inverse property 'specifically depends on at some time'] the one-sided dependence of an occurrent on an independent continuant: football match on the players, the ground, the ball [copied from inverse property 'specifically depends on at some time'] the one-sided dependence of an occurrent on an independent continuant: handwave on a hand [copied from inverse property 'specifically depends on at some time'] the three-sided reciprocal s-dependence of the hue, saturation and brightness of a color [45 [copied from inverse property 'specifically depends on at some time'] the three-sided reciprocal s-dependence of the pitch, timbre and volume of a tone [45 [copied from inverse property 'specifically depends on at some time'] the two-sided reciprocal s-dependence of the roles of husband and wife [20 [copied from inverse property 'specifically depends on at some time'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'specifically depends on at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'specifically depends on@en'(x,y,t) [copied from inverse property 'specifically depends on at some time'] BFO 2 Reference: An entity – for example an act of communication or a game of football – can s-depends_on more than one entity. Complex phenomena for example in the psychological and social realms (such as inferring, commanding and requesting) or in the realm of multi-organismal biological processes (such as infection and resistance), will involve multiple families of dependence relations, involving both continuants and occurrents [1, 4, 28 [copied from inverse property 'specifically depends on at some time'] BFO 2 Reference: S-dependence is just one type of dependence among many; it is what, in the literature, is referred to as ‘existential dependence’ [87, 46, 65, 20 [copied from inverse property 'specifically depends on at some time'] BFO 2 Reference: the relation of s-depends_on does not in every case require simultaneous existence of its relata. Note the difference between such cases and the cases of continuant universals defined historically: the act of answering depends existentially on the prior act of questioning; the human being who was baptized or who answered a question does not himself depend existentially on the prior act of baptism or answering. He would still exist even if these acts had never taken place. [copied from inverse property 'specifically depends on at some time'] BFO2 Reference: specifically dependent continuant\; process; process boundary [copied from inverse property 'specifically depends on at some time'] To say that b s-depends_on a at t is to say that b and c do not share common parts & b is of its nature such that it cannot exist unless c exists & b is not a boundary of c and b is not a site of which c is the host [64 has specific dependent at some time occupied-by [copied from inverse property 'occupies spatiotemporal region'] BFO 2 Reference: The occupies_spatiotemporal_region and occupies_temporal_region relations are the counterpart, on the occurrent side, of the relation occupies_spatial_region. [copied from inverse property 'occupies spatiotemporal region'] p occupies_spatiotemporal_region s. This is a primitive relation between an occurrent p and the spatiotemporal region s which is its spatiotemporal extent. (axiom label in BFO2 Reference: [082-003]) has spatiotemporal occupant material-basis-of_st material basis of at some time member-part-of_st memberPartOfAt each piece in a chess set is a member part of the chess set; each Beatle in the collection called The Beatles is a member part of The Beatles. each tree in a forest is a member_part of the forest b member_part_of c at t =Def. b is an object & there is at t a mutually exhaustive and pairwise disjoint partition of c into objects x1, …, xn (for some n &gt; 1) with b = xi for some 1 ? i ? n. (axiom label in BFO2 Reference: [026-004]) Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'member part of at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'member part of@en'(x,y,t) BFO2 Reference: object BFO2 Reference: object aggregate if b member_part_of c at t then b continuant_part_of c at t. (axiom label in BFO2 Reference: [104-001]) (forall (x y t) (if (memberPartOfAt x y t) (continuantPartOfAt x y t))) // axiom label in BFO2 CLIF: [104-001] member part of at some time b member_part_of c at t =Def. b is an object & there is at t a mutually exhaustive and pairwise disjoint partition of c into objects x1, …, xn (for some n &gt; 1) with b = xi for some 1 ? i ? n. (axiom label in BFO2 Reference: [026-004]) if b member_part_of c at t then b continuant_part_of c at t. (axiom label in BFO2 Reference: [104-001]) (forall (x y t) (if (memberPartOfAt x y t) (continuantPartOfAt x y t))) // axiom label in BFO2 CLIF: [104-001] occupies occupiesSpatiotemporalRegion BFO 2 Reference: The occupies_spatiotemporal_region and occupies_temporal_region relations are the counterpart, on the occurrent side, of the relation occupies_spatial_region. p occupies_spatiotemporal_region s. This is a primitive relation between an occurrent p and the spatiotemporal region s which is its spatiotemporal extent. (axiom label in BFO2 Reference: [082-003]) occupies spatiotemporal region p occupies_spatiotemporal_region s. This is a primitive relation between an occurrent p and the spatiotemporal region s which is its spatiotemporal extent. (axiom label in BFO2 Reference: [082-003]) profile-of processProfileOf process profile of t-ppart-of properTemporalPartOf proper temporal part of c-ppart-of_at properContinuantPartOfAt b proper_continuant_part_of c at t =Def. b continuant_part_of c at t & b and c are not identical. (axiom label in BFO2 Reference: [004-001]) Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'proper part of continuant at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'proper part of continuant@en(x,y,t)'. (iff (properContinuantPartOfAt a b t) (and (continuantPartOfAt a b t) (not (= a b)))) // axiom label in BFO2 CLIF: [004-001] proper part of continuant at all times b proper_continuant_part_of c at t =Def. b continuant_part_of c at t & b and c are not identical. (axiom label in BFO2 Reference: [004-001]) (iff (properContinuantPartOfAt a b t) (and (continuantPartOfAt a b t) (not (= a b)))) // axiom label in BFO2 CLIF: [004-001] o-ppart-of properOccurrentPartOf [copied from inverse property 'has proper occurrent part'] b has_proper_occurrent_part c = Def. c proper_occurrent_part_of b. [XXX-001 b proper_occurrent_part_of c =Def. b occurrent_part_of c & b and c are not identical. (axiom label in BFO2 Reference: [005-001]) (iff (properOccurrentPartOf a b) (and (occurrentPartOf a b) (not (= a b)))) // axiom label in BFO2 CLIF: [005-001] proper part of occurrent b proper_occurrent_part_of c =Def. b occurrent_part_of c & b and c are not identical. (axiom label in BFO2 Reference: [005-001]) (iff (properOccurrentPartOf a b) (and (occurrentPartOf a b) (not (= a b)))) // axiom label in BFO2 CLIF: [005-001] t-part-of temporalPartOf the 4th year of your life is a temporal part of your life\. The first quarter of a game of football is a temporal part of the whole game\. The process of your heart beating from 4pm to 5pm today is a temporal part of the entire process of your heart beating.\ The 4th year of your life is a temporal part of your life the process boundary which separates the 3rd and 4th years of your life. your heart beating from 4pm to 5pm today is a temporal part of the process of your heart beating b proper_temporal_part_of c =Def. b temporal_part_of c & not (b = c). (axiom label in BFO2 Reference: [116-001]) b temporal_part_of c =Def.b occurrent_part_of c & & for some temporal region t, b occupies_temporal_region t & for all occurrents d, t (if d occupies_temporal_region t & t? occurrent_part_of t then (d occurrent_part_of a iff d occurrent_part_of b)). (axiom label in BFO2 Reference: [078-003]) if b proper_temporal_part_of c, then there is some d which is a proper_temporal_part_of c and which shares no parts with b. (axiom label in BFO2 Reference: [117-002]) (forall (x y) (if (properTemporalPartOf x y) (exists (z) (and (properTemporalPartOf z y) (not (exists (w) (and (temporalPartOf w x) (temporalPartOf w z)))))))) // axiom label in BFO2 CLIF: [117-002] (iff (properTemporalPartOf a b) (and (temporalPartOf a b) (not (= a b)))) // axiom label in BFO2 CLIF: [116-001] (iff (temporalPartOf a b) (and (occurrentPartOf a b) (exists (t) (and (TemporalRegion t) (occupiesSpatioTemporalRegion a t))) (forall (c t_1) (if (and (Occurrent c) (occupiesSpatioTemporalRegion c t_1) (occurrentPartOf t_1 r)) (iff (occurrentPartOf c a) (occurrentPartOf c b)))))) // axiom label in BFO2 CLIF: [078-003] temporal part of b proper_temporal_part_of c =Def. b temporal_part_of c & not (b = c). (axiom label in BFO2 Reference: [116-001]) b temporal_part_of c =Def.b occurrent_part_of c & & for some temporal region t, b occupies_temporal_region t & for all occurrents d, t (if d occupies_temporal_region t & t? occurrent_part_of t then (d occurrent_part_of a iff d occurrent_part_of b)). (axiom label in BFO2 Reference: [078-003]) if b proper_temporal_part_of c, then there is some d which is a proper_temporal_part_of c and which shares no parts with b. (axiom label in BFO2 Reference: [117-002]) (forall (x y) (if (properTemporalPartOf x y) (exists (z) (and (properTemporalPartOf z y) (not (exists (w) (and (temporalPartOf w x) (temporalPartOf w z)))))))) // axiom label in BFO2 CLIF: [117-002] (iff (properTemporalPartOf a b) (and (temporalPartOf a b) (not (= a b)))) // axiom label in BFO2 CLIF: [116-001] (iff (temporalPartOf a b) (and (occurrentPartOf a b) (exists (t) (and (TemporalRegion t) (occupiesSpatioTemporalRegion a t))) (forall (c t_1) (if (and (Occurrent c) (occupiesSpatioTemporalRegion c t_1) (occurrentPartOf t_1 r)) (iff (occurrentPartOf c a) (occurrentPartOf c b)))))) // axiom label in BFO2 CLIF: [078-003] s-projection-of-st_st spatial projection of spatiotemporal at some time t-projection-of-st temporal projection of spatiotemporal spans occupiesTemporalRegion p occupies_temporal_region t. This is a primitive relation between an occurrent p and the temporal region t upon which the spatiotemporal region p occupies_spatiotemporal_region projects. (axiom label in BFO2 Reference: [132-001]) occupies temporal region p occupies_temporal_region t. This is a primitive relation between an occurrent p and the temporal region t upon which the spatiotemporal region p occupies_spatiotemporal_region projects. (axiom label in BFO2 Reference: [132-001]) span-of spanOf [copied from inverse property 'occupies temporal region'] p occupies_temporal_region t. This is a primitive relation between an occurrent p and the temporal region t upon which the spatiotemporal region p occupies_spatiotemporal_region projects. (axiom label in BFO2 Reference: [132-001]) has temporal occupant during-which-exists [copied from inverse property 'exists at'] BFO2 Reference: entity [copied from inverse property 'exists at'] BFO2 Reference: temporal region [copied from inverse property 'exists at'] b exists_at t means: b is an entity which exists at some temporal region t. (axiom label in BFO2 Reference: [118-002]) during which exists bearer-of_at bearerOfAt b bearer_of c at t =Def. c s-depends_on b at t & b is an independent continuant that is not a spatial region. (axiom label in BFO2 Reference: [053-004]) Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'bearer of at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'bearer of@en(x,y,t)'. BFO2 Reference: independent continuant that is not a spatial region BFO2 Reference: specifically dependent continuant (iff (bearerOfAt a b t) (and (specificallyDependsOnAt b a t) (IndependentContinuant a) (not (SpatialRegion a)) (existsAt b t))) // axiom label in BFO2 CLIF: [053-004] bearer of at all times b bearer_of c at t =Def. c s-depends_on b at t & b is an independent continuant that is not a spatial region. (axiom label in BFO2 Reference: [053-004]) (iff (bearerOfAt a b t) (and (specificallyDependsOnAt b a t) (IndependentContinuant a) (not (SpatialRegion a)) (existsAt b t))) // axiom label in BFO2 CLIF: [053-004] has-q_at has quality at all times has-f_at hasFunctionAt a has_function b at t =Def. b function_of a at t. (axiom label in BFO2 Reference: [070-001]) Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'has function at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'has function@en(x,y,t)'. (iff (hasFunctionAt a b t) (functionOf b a t)) // axiom label in BFO2 CLIF: [070-001] has function at all times a has_function b at t =Def. b function_of a at t. (axiom label in BFO2 Reference: [070-001]) (iff (hasFunctionAt a b t) (functionOf b a t)) // axiom label in BFO2 CLIF: [070-001] has-r_at hasRoleAt a has_role b at t =Def. b role_of a at t. (axiom label in BFO2 Reference: [068-001]) Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'has role at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'has role@en(x,y,t)'. (iff (hasRoleAt a b t) (roleOfAt b a t)) // axiom label in BFO2 CLIF: [068-001] has role at all times a has_role b at t =Def. b role_of a at t. (axiom label in BFO2 Reference: [068-001]) (iff (hasRoleAt a b t) (roleOfAt b a t)) // axiom label in BFO2 CLIF: [068-001] has-d_at hasDispositionAt a has_disposition b at t =Def. b disposition_of a at t. (axiom label in BFO2 Reference: [069-001]) Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'has disposition at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'has disposition@en(x,y,t)'. (iff (hasDispositionAt a b t) (dispositionOf b a t)) // axiom label in BFO2 CLIF: [069-001] has disposition at all times a has_disposition b at t =Def. b disposition_of a at t. (axiom label in BFO2 Reference: [069-001]) (iff (hasDispositionAt a b t) (dispositionOf b a t)) // axiom label in BFO2 CLIF: [069-001] material-basis-of_at material basis of at all times concretizes_at concretizesAt You may concretize a piece of software by installing it in your computer You may concretize a recipe that you find in a cookbook by turning it into a plan which exists as a realizable dependent continuant in your head. you may concretize a poem as a pattern of memory traces in your head Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'concretizes at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'concretizes@en(x,y,t)'. b concretizes c at t means: b is a specifically dependent continuant & c is a generically dependent continuant & for some independent continuant that is not a spatial region d, b s-depends_on d at t & c g-depends on d at t & if c migrates from bearer d to another bearer e than a copy of b will be created in e. (axiom label in BFO2 Reference: [075-002]) if b g-depends on c at some time t, then there is some d, such that d concretizes b at t and d s-depends_on c at t. (axiom label in BFO2 Reference: [076-001]) (forall (x y t) (if (concretizesAt x y t) (and (SpecificallyDependentContinuant x) (GenericallyDependentContinuant y) (exists (z) (and (IndependentContinuant z) (specificallyDependsOnAt x z t) (genericallyDependsOnAt y z t)))))) // axiom label in BFO2 CLIF: [075-002] (forall (x y t) (if (genericallyDependsOnAt x y t) (exists (z) (and (concretizesAt z x t) (specificallyDependsOnAt z y t))))) // axiom label in BFO2 CLIF: [076-001] concretizes at all times b concretizes c at t means: b is a specifically dependent continuant & c is a generically dependent continuant & for some independent continuant that is not a spatial region d, b s-depends_on d at t & c g-depends on d at t & if c migrates from bearer d to another bearer e than a copy of b will be created in e. (axiom label in BFO2 Reference: [075-002]) if b g-depends on c at some time t, then there is some d, such that d concretizes b at t and d s-depends_on c at t. (axiom label in BFO2 Reference: [076-001]) (forall (x y t) (if (concretizesAt x y t) (and (SpecificallyDependentContinuant x) (GenericallyDependentContinuant y) (exists (z) (and (IndependentContinuant z) (specificallyDependsOnAt x z t) (genericallyDependsOnAt y z t)))))) // axiom label in BFO2 CLIF: [075-002] (forall (x y t) (if (genericallyDependsOnAt x y t) (exists (z) (and (concretizesAt z x t) (specificallyDependsOnAt z y t))))) // axiom label in BFO2 CLIF: [076-001] concretized-by_at concretized by at all times participates-in_at participatesInAt participates in at all times has-s-dep_at has specific dependent at all times has-location_at has location at all times located-in_st locatedInAt Mary located_in Salzburg the Empire State Building located_in New York. this portion of cocaine located_in this portion of blood this stem cell located_in this portion of bone marrow your arm located_in your body b located_in c at t = Def. b and c are independent continuants, and the region at which b is located at t is a (proper or improper) continuant_part_of the region at which c is located at t. (axiom label in BFO2 Reference: [045-001]) Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'located in at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'located in@en'(x,y,t) BFO2 Reference: independent continuant Located_in is transitive. (axiom label in BFO2 Reference: [046-001]) for all independent continuants b, c, and d: if b continuant_part_of c at t & c located_in d at t, then b located_in d at t. (axiom label in BFO2 Reference: [048-001]) for all independent continuants b, c, and d: if b located_in c at t & c continuant_part_of d at t, then b located_in d at t. (axiom label in BFO2 Reference: [049-001]) (forall (x y z t) (if (and (IndependentContinuant x) (IndependentContinuant y) (IndependentContinuant z) (continuantPartOfAt x y t) (locatedInAt y z t)) (locatedInAt x z t))) // axiom label in BFO2 CLIF: [048-001] (forall (x y z t) (if (and (IndependentContinuant x) (IndependentContinuant y) (IndependentContinuant z) (locatedInAt x y t) (continuantPartOfAt y z t)) (locatedInAt x z t))) // axiom label in BFO2 CLIF: [049-001] (forall (x y z t) (if (and (locatedInAt x y t) (locatedInAt y z t)) (locatedInAt x z t))) // axiom label in BFO2 CLIF: [046-001] (iff (locatedInAt a b t) (and (IndependentContinuant a) (IndependentContinuant b) (exists (r_1 r_2) (and (occupiesSpatialRegionAt a r_1 t) (occupiesSpatialRegionAt b r_2 t) (continuantPartOfAt r_1 r_2 t))))) // axiom label in BFO2 CLIF: [045-001] located in at some time b located_in c at t = Def. b and c are independent continuants, and the region at which b is located at t is a (proper or improper) continuant_part_of the region at which c is located at t. (axiom label in BFO2 Reference: [045-001]) Located_in is transitive. (axiom label in BFO2 Reference: [046-001]) for all independent continuants b, c, and d: if b continuant_part_of c at t & c located_in d at t, then b located_in d at t. (axiom label in BFO2 Reference: [048-001]) for all independent continuants b, c, and d: if b located_in c at t & c continuant_part_of d at t, then b located_in d at t. (axiom label in BFO2 Reference: [049-001]) (forall (x y z t) (if (and (IndependentContinuant x) (IndependentContinuant y) (IndependentContinuant z) (continuantPartOfAt x y t) (locatedInAt y z t)) (locatedInAt x z t))) // axiom label in BFO2 CLIF: [048-001] (forall (x y z t) (if (and (IndependentContinuant x) (IndependentContinuant y) (IndependentContinuant z) (locatedInAt x y t) (continuantPartOfAt y z t)) (locatedInAt x z t))) // axiom label in BFO2 CLIF: [049-001] (forall (x y z t) (if (and (locatedInAt x y t) (locatedInAt y z t)) (locatedInAt x z t))) // axiom label in BFO2 CLIF: [046-001] (iff (locatedInAt a b t) (and (IndependentContinuant a) (IndependentContinuant b) (exists (r_1 r_2) (and (occupiesSpatialRegionAt a r_1 t) (occupiesSpatialRegionAt b r_2 t) (continuantPartOfAt r_1 r_2 t))))) // axiom label in BFO2 CLIF: [045-001] has-member-part_at has member part at all times member-part-of_at memberPartOfAt each piece in a chess set is a member part of the chess set; each Beatle in the collection called The Beatles is a member part of The Beatles. each tree in a forest is a member_part of the forest b member_part_of c at t =Def. b is an object & there is at t a mutually exhaustive and pairwise disjoint partition of c into objects x1, …, xn (for some n &gt; 1) with b = xi for some 1 ? i ? n. (axiom label in BFO2 Reference: [026-004]) Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'member part of at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'member part of@en(x,y,t)'. BFO2 Reference: object BFO2 Reference: object aggregate if b member_part_of c at t then b continuant_part_of c at t. (axiom label in BFO2 Reference: [104-001]) (forall (x y t) (if (memberPartOfAt x y t) (continuantPartOfAt x y t))) // axiom label in BFO2 CLIF: [104-001] member part of at all times b member_part_of c at t =Def. b is an object & there is at t a mutually exhaustive and pairwise disjoint partition of c into objects x1, …, xn (for some n &gt; 1) with b = xi for some 1 ? i ? n. (axiom label in BFO2 Reference: [026-004]) if b member_part_of c at t then b continuant_part_of c at t. (axiom label in BFO2 Reference: [104-001]) (forall (x y t) (if (memberPartOfAt x y t) (continuantPartOfAt x y t))) // axiom label in BFO2 CLIF: [104-001] c-has-ppart_st hasProperContinuantPartAt [copied from inverse property 'proper part of continuant at some time'] b proper_continuant_part_of c at t =Def. b continuant_part_of c at t & b and c are not identical. (axiom label in BFO2 Reference: [004-001]) b has_proper_continuant_part c at t = Def. c proper_continuant_part_of b at t. [XXX-001 Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'has proper continuant part at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'has proper continuant part@en'(x,y,t) [copied from inverse property 'proper part of continuant at some time'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'proper part of continuant at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'proper part of continuant@en'(x,y,t) has proper continuant part at some time c-ppart-of_st properContinuantPartOfAt [copied from inverse property 'has proper continuant part at some time'] b has_proper_continuant_part c at t = Def. c proper_continuant_part_of b at t. [XXX-001 b proper_continuant_part_of c at t =Def. b continuant_part_of c at t & b and c are not identical. (axiom label in BFO2 Reference: [004-001]) Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'proper part of continuant at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'proper part of continuant@en'(x,y,t) [copied from inverse property 'has proper continuant part at some time'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'has proper continuant part at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'has proper continuant part@en'(x,y,t) (iff (properContinuantPartOfAt a b t) (and (continuantPartOfAt a b t) (not (= a b)))) // axiom label in BFO2 CLIF: [004-001] proper part of continuant at some time b proper_continuant_part_of c at t =Def. b continuant_part_of c at t & b and c are not identical. (axiom label in BFO2 Reference: [004-001]) (iff (properContinuantPartOfAt a b t) (and (continuantPartOfAt a b t) (not (= a b)))) // axiom label in BFO2 CLIF: [004-001] c-part-of_st continuantPartOfAt Mary’s arm continuant_part_of Mary in the time of her life prior to her operation the Northern hemisphere of the planet Earth is a part of the planet Earth at all times at which the planet Earth exists. [copied from inverse property 'has continuant part at some time'] b has_continuant_part c at t = Def. c continuant_part_of b at t. (axiom label in BFO2 Reference: [006-001]) Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'part of continuant at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'part of continuant@en'(x,y,t) BFO 2 Reference: Immaterial entities are in some cases continuant parts of their material hosts. Thus the hold of a ship, for example, is a part of the ship; it may itself have parts, which may have names (used for example by ship stow planners, customs inspectors, and the like). Immaterial entities under both 1. and 2. can be of zero, one, two or three dimensions. We define:a(immaterial entity)[Definition: a is an immaterial entity = Def. a is an independent continuant that has no material entities as parts. (axiom label in BFO2 Reference: [028-001]) BFO 2 Reference: a (continuant or occurrent) part of itself. We appreciate that this is counterintuitive for some users, since it implies for example that President Obama is a part of himself. However it brings benefits in simplifying the logical formalism, and it captures an important feature of identity, namely that it is the limit case of mereological inclusion. BFO2 Reference: continuant BFO2 Reference: continuantThe range for ‘t’ (as in all cases throughout this document unless otherwise specified) is: temporal region. [copied from inverse property 'has continuant part at some time'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'has continuant part at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'has continuant part@en'(x,y,t) b continuant_part_of c at t =Def. b is a part of c at t & t is a time & b and c are continuants. (axiom label in BFO2 Reference: [002-001]) continuant_part_of is antisymmetric. (axiom label in BFO2 Reference: [120-001]) continuant_part_of is reflexive (every continuant entity is a continuant_part_of itself). (axiom label in BFO2 Reference: [111-002]) continuant_part_of is transitive. (axiom label in BFO2 Reference: [110-001]) continuant_part_of satisfies unique product. (axiom label in BFO2 Reference: [122-001]) continuant_part_of satisfies weak supplementation. (axiom label in BFO2 Reference: [121-001]) if b continuant_part_of c at t and b is an independent continuant, then b is located_in c at t. (axiom label in BFO2 Reference: [047-002]) (forall (x t) (if (Continuant x) (continuantPartOfAt x x t))) // axiom label in BFO2 CLIF: [111-002] (forall (x y t) (if (and (continuantPartOfAt x y t) (IndependentContinuant x)) (locatedInAt x y t))) // axiom label in BFO2 CLIF: [047-002] (forall (x y t) (if (and (continuantPartOfAt x y t) (continuantPartOfAt y x t)) (= x y))) // axiom label in BFO2 CLIF: [120-001] (forall (x y t) (if (and (continuantPartOfAt x y t) (not (= x y))) (exists (z) (and (continuantPartOfAt z y t) (not (exists (w) (and (continuantPartOfAt w x t) (continuantPartOfAt w z t)))))))) // axiom label in BFO2 CLIF: [121-001] (forall (x y t) (if (exists (v) (and (continuantPartOfAt v x t) (continuantPartOfAt v y t))) (exists (z) (forall (u w) (iff (iff (continuantPartOfAt w u t) (and (continuantPartOfAt w x t) (continuantPartOfAt w y t))) (= z u)))))) // axiom label in BFO2 CLIF: [122-001] (forall (x y z t) (if (and (continuantPartOfAt x y t) (continuantPartOfAt y z t)) (continuantPartOfAt x z t))) // axiom label in BFO2 CLIF: [110-001] (iff (ImmaterialEntity a) (and (IndependentContinuant a) (not (exists (b t) (and (MaterialEntity b) (continuantPartOfAt b a t)))))) // axiom label in BFO2 CLIF: [028-001] part of continuant at some time BFO 2 Reference: Immaterial entities are in some cases continuant parts of their material hosts. Thus the hold of a ship, for example, is a part of the ship; it may itself have parts, which may have names (used for example by ship stow planners, customs inspectors, and the like). Immaterial entities under both 1. and 2. can be of zero, one, two or three dimensions. We define:a(immaterial entity)[Definition: a is an immaterial entity = Def. a is an independent continuant that has no material entities as parts. (axiom label in BFO2 Reference: [028-001]) b continuant_part_of c at t =Def. b is a part of c at t & t is a time & b and c are continuants. (axiom label in BFO2 Reference: [002-001]) continuant_part_of is antisymmetric. (axiom label in BFO2 Reference: [120-001]) continuant_part_of is reflexive (every continuant entity is a continuant_part_of itself). (axiom label in BFO2 Reference: [111-002]) continuant_part_of is transitive. (axiom label in BFO2 Reference: [110-001]) continuant_part_of satisfies unique product. (axiom label in BFO2 Reference: [122-001]) continuant_part_of satisfies weak supplementation. (axiom label in BFO2 Reference: [121-001]) if b continuant_part_of c at t and b is an independent continuant, then b is located_in c at t. (axiom label in BFO2 Reference: [047-002]) (forall (x t) (if (Continuant x) (continuantPartOfAt x x t))) // axiom label in BFO2 CLIF: [111-002] (forall (x y t) (if (and (continuantPartOfAt x y t) (IndependentContinuant x)) (locatedInAt x y t))) // axiom label in BFO2 CLIF: [047-002] (forall (x y t) (if (and (continuantPartOfAt x y t) (continuantPartOfAt y x t)) (= x y))) // axiom label in BFO2 CLIF: [120-001] (forall (x y t) (if (and (continuantPartOfAt x y t) (not (= x y))) (exists (z) (and (continuantPartOfAt z y t) (not (exists (w) (and (continuantPartOfAt w x t) (continuantPartOfAt w z t)))))))) // axiom label in BFO2 CLIF: [121-001] (forall (x y t) (if (exists (v) (and (continuantPartOfAt v x t) (continuantPartOfAt v y t))) (exists (z) (forall (u w) (iff (iff (continuantPartOfAt w u t) (and (continuantPartOfAt w x t) (continuantPartOfAt w y t))) (= z u)))))) // axiom label in BFO2 CLIF: [122-001] (forall (x y z t) (if (and (continuantPartOfAt x y t) (continuantPartOfAt y z t)) (continuantPartOfAt x z t))) // axiom label in BFO2 CLIF: [110-001] (iff (ImmaterialEntity a) (and (IndependentContinuant a) (not (exists (b t) (and (MaterialEntity b) (continuantPartOfAt b a t)))))) // axiom label in BFO2 CLIF: [028-001] c-part-of_at continuantPartOfAt Mary’s arm continuant_part_of Mary in the time of her life prior to her operation the Northern hemisphere of the planet Earth is a part of the planet Earth at all times at which the planet Earth exists. [copied from inverse property 'has continuant part at all times that part exists'] forall(t) exists_at(y,t) -> exists_at(x,t) and 'has continuant part'(x,y,t) Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'part of continuant at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'part of continuant@en(x,y,t)'. BFO 2 Reference: Immaterial entities are in some cases continuant parts of their material hosts. Thus the hold of a ship, for example, is a part of the ship; it may itself have parts, which may have names (used for example by ship stow planners, customs inspectors, and the like). Immaterial entities under both 1. and 2. can be of zero, one, two or three dimensions. We define:a(immaterial entity)[Definition: a is an immaterial entity = Def. a is an independent continuant that has no material entities as parts. (axiom label in BFO2 Reference: [028-001]) BFO 2 Reference: a (continuant or occurrent) part of itself. We appreciate that this is counterintuitive for some users, since it implies for example that President Obama is a part of himself. However it brings benefits in simplifying the logical formalism, and it captures an important feature of identity, namely that it is the limit case of mereological inclusion. BFO2 Reference: continuant BFO2 Reference: continuantThe range for ‘t’ (as in all cases throughout this document unless otherwise specified) is: temporal region. [copied from inverse property 'has continuant part at all times that part exists'] This is a binary version of a ternary time-indexed, instance level, relation. Unlike the rest of the temporalized relations which temporally quantify over existence of the subject of the relation, this relation temporally quantifies over the existence of the object of the relation. The relation is provided tentatively, to assess whether the GO needs such a relation. It is inverse of 'part of continuant at all times' b continuant_part_of c at t =Def. b is a part of c at t & t is a time & b and c are continuants. (axiom label in BFO2 Reference: [002-001]) continuant_part_of is antisymmetric. (axiom label in BFO2 Reference: [120-001]) continuant_part_of is reflexive (every continuant entity is a continuant_part_of itself). (axiom label in BFO2 Reference: [111-002]) continuant_part_of is transitive. (axiom label in BFO2 Reference: [110-001]) continuant_part_of satisfies unique product. (axiom label in BFO2 Reference: [122-001]) continuant_part_of satisfies weak supplementation. (axiom label in BFO2 Reference: [121-001]) if b continuant_part_of c at t and b is an independent continuant, then b is located_in c at t. (axiom label in BFO2 Reference: [047-002]) (forall (x t) (if (Continuant x) (continuantPartOfAt x x t))) // axiom label in BFO2 CLIF: [111-002] (forall (x y t) (if (and (continuantPartOfAt x y t) (IndependentContinuant x)) (locatedInAt x y t))) // axiom label in BFO2 CLIF: [047-002] (forall (x y t) (if (and (continuantPartOfAt x y t) (continuantPartOfAt y x t)) (= x y))) // axiom label in BFO2 CLIF: [120-001] (forall (x y t) (if (and (continuantPartOfAt x y t) (not (= x y))) (exists (z) (and (continuantPartOfAt z y t) (not (exists (w) (and (continuantPartOfAt w x t) (continuantPartOfAt w z t)))))))) // axiom label in BFO2 CLIF: [121-001] (forall (x y t) (if (exists (v) (and (continuantPartOfAt v x t) (continuantPartOfAt v y t))) (exists (z) (forall (u w) (iff (iff (continuantPartOfAt w u t) (and (continuantPartOfAt w x t) (continuantPartOfAt w y t))) (= z u)))))) // axiom label in BFO2 CLIF: [122-001] (forall (x y z t) (if (and (continuantPartOfAt x y t) (continuantPartOfAt y z t)) (continuantPartOfAt x z t))) // axiom label in BFO2 CLIF: [110-001] (iff (ImmaterialEntity a) (and (IndependentContinuant a) (not (exists (b t) (and (MaterialEntity b) (continuantPartOfAt b a t)))))) // axiom label in BFO2 CLIF: [028-001] part of continuant at all times BFO 2 Reference: Immaterial entities are in some cases continuant parts of their material hosts. Thus the hold of a ship, for example, is a part of the ship; it may itself have parts, which may have names (used for example by ship stow planners, customs inspectors, and the like). Immaterial entities under both 1. and 2. can be of zero, one, two or three dimensions. We define:a(immaterial entity)[Definition: a is an immaterial entity = Def. a is an independent continuant that has no material entities as parts. (axiom label in BFO2 Reference: [028-001]) b continuant_part_of c at t =Def. b is a part of c at t & t is a time & b and c are continuants. (axiom label in BFO2 Reference: [002-001]) continuant_part_of is antisymmetric. (axiom label in BFO2 Reference: [120-001]) continuant_part_of is reflexive (every continuant entity is a continuant_part_of itself). (axiom label in BFO2 Reference: [111-002]) continuant_part_of is transitive. (axiom label in BFO2 Reference: [110-001]) continuant_part_of satisfies unique product. (axiom label in BFO2 Reference: [122-001]) continuant_part_of satisfies weak supplementation. (axiom label in BFO2 Reference: [121-001]) if b continuant_part_of c at t and b is an independent continuant, then b is located_in c at t. (axiom label in BFO2 Reference: [047-002]) (forall (x t) (if (Continuant x) (continuantPartOfAt x x t))) // axiom label in BFO2 CLIF: [111-002] (forall (x y t) (if (and (continuantPartOfAt x y t) (IndependentContinuant x)) (locatedInAt x y t))) // axiom label in BFO2 CLIF: [047-002] (forall (x y t) (if (and (continuantPartOfAt x y t) (continuantPartOfAt y x t)) (= x y))) // axiom label in BFO2 CLIF: [120-001] (forall (x y t) (if (and (continuantPartOfAt x y t) (not (= x y))) (exists (z) (and (continuantPartOfAt z y t) (not (exists (w) (and (continuantPartOfAt w x t) (continuantPartOfAt w z t)))))))) // axiom label in BFO2 CLIF: [121-001] (forall (x y t) (if (exists (v) (and (continuantPartOfAt v x t) (continuantPartOfAt v y t))) (exists (z) (forall (u w) (iff (iff (continuantPartOfAt w u t) (and (continuantPartOfAt w x t) (continuantPartOfAt w y t))) (= z u)))))) // axiom label in BFO2 CLIF: [122-001] (forall (x y z t) (if (and (continuantPartOfAt x y t) (continuantPartOfAt y z t)) (continuantPartOfAt x z t))) // axiom label in BFO2 CLIF: [110-001] (iff (ImmaterialEntity a) (and (IndependentContinuant a) (not (exists (b t) (and (MaterialEntity b) (continuantPartOfAt b a t)))))) // axiom label in BFO2 CLIF: [028-001] c-has-part_st hasContinuantPartAt [copied from inverse property 'part of continuant at some time'] Mary’s arm continuant_part_of Mary in the time of her life prior to her operation [copied from inverse property 'part of continuant at some time'] the Northern hemisphere of the planet Earth is a part of the planet Earth at all times at which the planet Earth exists. b has_continuant_part c at t = Def. c continuant_part_of b at t. (axiom label in BFO2 Reference: [006-001]) Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'has continuant part at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'has continuant part@en'(x,y,t) [copied from inverse property 'part of continuant at some time'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'part of continuant at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'part of continuant@en'(x,y,t) [copied from inverse property 'part of continuant at some time'] BFO 2 Reference: Immaterial entities are in some cases continuant parts of their material hosts. Thus the hold of a ship, for example, is a part of the ship; it may itself have parts, which may have names (used for example by ship stow planners, customs inspectors, and the like). Immaterial entities under both 1. and 2. can be of zero, one, two or three dimensions. We define:a(immaterial entity)[Definition: a is an immaterial entity = Def. a is an independent continuant that has no material entities as parts. (axiom label in BFO2 Reference: [028-001]) [copied from inverse property 'part of continuant at some time'] BFO 2 Reference: a (continuant or occurrent) part of itself. We appreciate that this is counterintuitive for some users, since it implies for example that President Obama is a part of himself. However it brings benefits in simplifying the logical formalism, and it captures an important feature of identity, namely that it is the limit case of mereological inclusion. [copied from inverse property 'part of continuant at some time'] BFO2 Reference: continuant [copied from inverse property 'part of continuant at some time'] BFO2 Reference: continuantThe range for ‘t’ (as in all cases throughout this document unless otherwise specified) is: temporal region. [copied from inverse property 'part of continuant at some time'] b continuant_part_of c at t =Def. b is a part of c at t & t is a time & b and c are continuants. (axiom label in BFO2 Reference: [002-001]) (iff (hasContinuantPartAt a b t) (continuantPartOfAt b a t)) // axiom label in BFO2 CLIF: [006-001] has continuant part at some time b has_continuant_part c at t = Def. c continuant_part_of b at t. (axiom label in BFO2 Reference: [006-001]) (iff (hasContinuantPartAt a b t) (continuantPartOfAt b a t)) // axiom label in BFO2 CLIF: [006-001] has-t-ppart has proper temporal part has-history hasHistory b has_history c iff c history_of b [XXX-001 [copied from inverse property 'history of'] b history_of c if c is a material entity or site and b is a history that is the unique history of cAxiom: if b history_of c and b history_of d then c=d [XXX-001 has history c-part-of-object_at [copied from inverse property 'has continuant part at all times'] b has_continuant_part c at t = Def. c continuant_part_of b at t. (axiom label in BFO2 Reference: [006-001]) forall(t) exists_at(y,t) -> exists_at(x,t) and 'part of continuant'(x,y,t) This is a binary version of a ternary time-indexed, instance level, relation. Unlike the rest of the temporalized relations which temporally quantify over existence of the subject of the relation, this relation temporally quantifies over the existence of the object of the relation. The relation is provided tentatively, to assess whether the GO needs such a relation. It is inverse of 'has continuant part at all times' [copied from inverse property 'has continuant part at all times'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'has continuant part at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'has continuant part@en(x,y,t)'. part of continuant at all times that whole exists forall(t) exists_at(y,t) -> exists_at(x,t) and 'part of continuant'(x,y,t) This is a binary version of a ternary time-indexed, instance level, relation. Unlike the rest of the temporalized relations which temporally quantify over existence of the subject of the relation, this relation temporally quantifies over the existence of the object of the relation. The relation is provided tentatively, to assess whether the GO needs such a relation. It is inverse of 'has continuant part at all times' c-has-part-object_at [copied from inverse property 'part of continuant at all times'] Mary’s arm continuant_part_of Mary in the time of her life prior to her operation [copied from inverse property 'part of continuant at all times'] the Northern hemisphere of the planet Earth is a part of the planet Earth at all times at which the planet Earth exists. forall(t) exists_at(y,t) -> exists_at(x,t) and 'has continuant part'(x,y,t) This is a binary version of a ternary time-indexed, instance level, relation. Unlike the rest of the temporalized relations which temporally quantify over existence of the subject of the relation, this relation temporally quantifies over the existence of the object of the relation. The relation is provided tentatively, to assess whether the GO needs such a relation. It is inverse of 'part of continuant at all times' [copied from inverse property 'part of continuant at all times'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'part of continuant at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'part of continuant@en(x,y,t)'. [copied from inverse property 'part of continuant at all times'] BFO 2 Reference: Immaterial entities are in some cases continuant parts of their material hosts. Thus the hold of a ship, for example, is a part of the ship; it may itself have parts, which may have names (used for example by ship stow planners, customs inspectors, and the like). Immaterial entities under both 1. and 2. can be of zero, one, two or three dimensions. We define:a(immaterial entity)[Definition: a is an immaterial entity = Def. a is an independent continuant that has no material entities as parts. (axiom label in BFO2 Reference: [028-001]) [copied from inverse property 'part of continuant at all times'] BFO 2 Reference: a (continuant or occurrent) part of itself. We appreciate that this is counterintuitive for some users, since it implies for example that President Obama is a part of himself. However it brings benefits in simplifying the logical formalism, and it captures an important feature of identity, namely that it is the limit case of mereological inclusion. [copied from inverse property 'part of continuant at all times'] BFO2 Reference: continuant [copied from inverse property 'part of continuant at all times'] BFO2 Reference: continuantThe range for ‘t’ (as in all cases throughout this document unless otherwise specified) is: temporal region. [copied from inverse property 'part of continuant at all times'] b continuant_part_of c at t =Def. b is a part of c at t & t is a time & b and c are continuants. (axiom label in BFO2 Reference: [002-001]) has continuant part at all times that part exists forall(t) exists_at(y,t) -> exists_at(x,t) and 'has continuant part'(x,y,t) This is a binary version of a ternary time-indexed, instance level, relation. Unlike the rest of the temporalized relations which temporally quantify over existence of the subject of the relation, this relation temporally quantifies over the existence of the object of the relation. The relation is provided tentatively, to assess whether the GO needs such a relation. It is inverse of 'part of continuant at all times' BFO:0000001 entity Entity Julius Caesar Verdi’s Requiem the Second World War your body mass index BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81 Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001]) entity Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf per discussion with Barry Smith An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001]) BFO:0000002 continuant Continuant BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240 Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002]) if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001]) if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002]) if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002]) (forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002] (forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001] (forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002] (forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002] continuant Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002]) if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001]) if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002]) if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002]) (forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002] (forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001] (forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002] (forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002] BFO:0000003 occurrent Occurrent BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players. Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process. Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame. An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002]) Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001]) b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001]) (forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001] (forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001] occurrent Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process. per discussion with Barry Smith Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame. An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002]) Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001]) b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001]) (forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001] (forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001] BFO:0000004 ic IndependentContinuant a chair a heart a leg a molecule a spatial region an atom an orchestra. an organism the bottom right portion of a human torso the interior of your mouth b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002]) For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001]) For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002]) (forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001] (forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002] (iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002] independent continuant b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002]) For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001]) For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002]) (forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001] (forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002] (iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002] BFO:0000006 s-region SpatialRegion BFO 2 Reference: Spatial regions do not participate in processes. Spatial region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the union of a spatial point and a spatial line that doesn't overlap the point, or two spatial lines that intersect at a single point. In both cases the resultant spatial region is neither 0-dimensional, 1-dimensional, 2-dimensional, or 3-dimensional. A spatial region is a continuant entity that is a continuant_part_of spaceR as defined relative to some frame R. (axiom label in BFO2 Reference: [035-001]) All continuant parts of spatial regions are spatial regions. (axiom label in BFO2 Reference: [036-001]) (forall (x y t) (if (and (SpatialRegion x) (continuantPartOfAt y x t)) (SpatialRegion y))) // axiom label in BFO2 CLIF: [036-001] (forall (x) (if (SpatialRegion x) (Continuant x))) // axiom label in BFO2 CLIF: [035-001] spatial region true true Spatial region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the union of a spatial point and a spatial line that doesn't overlap the point, or two spatial lines that intersect at a single point. In both cases the resultant spatial region is neither 0-dimensional, 1-dimensional, 2-dimensional, or 3-dimensional. per discussion with Barry Smith A spatial region is a continuant entity that is a continuant_part_of spaceR as defined relative to some frame R. (axiom label in BFO2 Reference: [035-001]) All continuant parts of spatial regions are spatial regions. (axiom label in BFO2 Reference: [036-001]) (forall (x y t) (if (and (SpatialRegion x) (continuantPartOfAt y x t)) (SpatialRegion y))) // axiom label in BFO2 CLIF: [036-001] (forall (x) (if (SpatialRegion x) (Continuant x))) // axiom label in BFO2 CLIF: [035-001] BFO:0000008 t-region TemporalRegion Temporal region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the mereological sum of a temporal instant and a temporal interval that doesn't overlap the instant. In this case the resultant temporal region is neither 0-dimensional nor 1-dimensional A temporal region is an occurrent entity that is part of time as defined relative to some reference frame. (axiom label in BFO2 Reference: [100-001]) All parts of temporal regions are temporal regions. (axiom label in BFO2 Reference: [101-001]) Every temporal region t is such that t occupies_temporal_region t. (axiom label in BFO2 Reference: [119-002]) (forall (r) (if (TemporalRegion r) (occupiesTemporalRegion r r))) // axiom label in BFO2 CLIF: [119-002] (forall (x y) (if (and (TemporalRegion x) (occurrentPartOf y x)) (TemporalRegion y))) // axiom label in BFO2 CLIF: [101-001] (forall (x) (if (TemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [100-001] temporal region true true Temporal region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the mereological sum of a temporal instant and a temporal interval that doesn't overlap the instant. In this case the resultant temporal region is neither 0-dimensional nor 1-dimensional per discussion with Barry Smith A temporal region is an occurrent entity that is part of time as defined relative to some reference frame. (axiom label in BFO2 Reference: [100-001]) All parts of temporal regions are temporal regions. (axiom label in BFO2 Reference: [101-001]) Every temporal region t is such that t occupies_temporal_region t. (axiom label in BFO2 Reference: [119-002]) (forall (r) (if (TemporalRegion r) (occupiesTemporalRegion r r))) // axiom label in BFO2 CLIF: [119-002] (forall (x y) (if (and (TemporalRegion x) (occurrentPartOf y x)) (TemporalRegion y))) // axiom label in BFO2 CLIF: [101-001] (forall (x) (if (TemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [100-001] BFO:0000009 2d-s-region TwoDimensionalSpatialRegion an infinitely thin plane in space. the surface of a sphere-shaped part of space A two-dimensional spatial region is a spatial region that is of two dimensions. (axiom label in BFO2 Reference: [039-001]) (forall (x) (if (TwoDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [039-001] two-dimensional spatial region A two-dimensional spatial region is a spatial region that is of two dimensions. (axiom label in BFO2 Reference: [039-001]) (forall (x) (if (TwoDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [039-001] BFO:0000011 st-region SpatiotemporalRegion the spatiotemporal region occupied by a human life the spatiotemporal region occupied by a process of cellular meiosis. the spatiotemporal region occupied by the development of a cancer tumor A spatiotemporal region is an occurrent entity that is part of spacetime. (axiom label in BFO2 Reference: [095-001]) All parts of spatiotemporal regions are spatiotemporal regions. (axiom label in BFO2 Reference: [096-001]) Each spatiotemporal region at any time t projects_onto some spatial region at t. (axiom label in BFO2 Reference: [099-001]) Each spatiotemporal region projects_onto some temporal region. (axiom label in BFO2 Reference: [098-001]) Every spatiotemporal region occupies_spatiotemporal_region itself. Every spatiotemporal region s is such that s occupies_spatiotemporal_region s. (axiom label in BFO2 Reference: [107-002]) (forall (r) (if (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion r r))) // axiom label in BFO2 CLIF: [107-002] (forall (x t) (if (SpatioTemporalRegion x) (exists (y) (and (SpatialRegion y) (spatiallyProjectsOntoAt x y t))))) // axiom label in BFO2 CLIF: [099-001] (forall (x y) (if (and (SpatioTemporalRegion x) (occurrentPartOf y x)) (SpatioTemporalRegion y))) // axiom label in BFO2 CLIF: [096-001] (forall (x) (if (SpatioTemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [095-001] (forall (x) (if (SpatioTemporalRegion x) (exists (y) (and (TemporalRegion y) (temporallyProjectsOnto x y))))) // axiom label in BFO2 CLIF: [098-001] spatiotemporal region true true A spatiotemporal region is an occurrent entity that is part of spacetime. (axiom label in BFO2 Reference: [095-001]) All parts of spatiotemporal regions are spatiotemporal regions. (axiom label in BFO2 Reference: [096-001]) Each spatiotemporal region at any time t projects_onto some spatial region at t. (axiom label in BFO2 Reference: [099-001]) Each spatiotemporal region projects_onto some temporal region. (axiom label in BFO2 Reference: [098-001]) Every spatiotemporal region s is such that s occupies_spatiotemporal_region s. (axiom label in BFO2 Reference: [107-002]) (forall (r) (if (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion r r))) // axiom label in BFO2 CLIF: [107-002] (forall (x t) (if (SpatioTemporalRegion x) (exists (y) (and (SpatialRegion y) (spatiallyProjectsOntoAt x y t))))) // axiom label in BFO2 CLIF: [099-001] (forall (x y) (if (and (SpatioTemporalRegion x) (occurrentPartOf y x)) (SpatioTemporalRegion y))) // axiom label in BFO2 CLIF: [096-001] (forall (x) (if (SpatioTemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [095-001] (forall (x) (if (SpatioTemporalRegion x) (exists (y) (and (TemporalRegion y) (temporallyProjectsOnto x y))))) // axiom label in BFO2 CLIF: [098-001] BFO:0000015 process Process a process of cell-division, \ a beating of the heart a process of meiosis a process of sleeping the course of a disease the flight of a bird the life of an organism your process of aging. p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003]) BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war) (iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003] process p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003]) (iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003] BFO:0000016 disposition Disposition an atom of element X has the disposition to decay to an atom of element Y certain people have a predisposition to colon cancer children are innately disposed to categorize objects in certain ways. the cell wall is disposed to filter chemicals in endocytosis and exocytosis BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type. b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002]) If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002]) (forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002] (forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002] disposition b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002]) If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002]) (forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002] (forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002] BFO:0000017 realizable RealizableEntity the disposition of this piece of metal to conduct electricity. the disposition of your blood to coagulate the function of your reproductive organs the role of being a doctor the role of this boundary to delineate where Utah and Colorado meet To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002]) All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002]) (forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002] (forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002] realizable entity To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002]) All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002]) (forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002] (forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002] BFO:0000018 0d-s-region ZeroDimensionalSpatialRegion A zero-dimensional spatial region is a point in space. (axiom label in BFO2 Reference: [037-001]) (forall (x) (if (ZeroDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [037-001] zero-dimensional spatial region A zero-dimensional spatial region is a point in space. (axiom label in BFO2 Reference: [037-001]) (forall (x) (if (ZeroDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [037-001] BFO:0000019 quality Quality the ambient temperature of this portion of air the color of a tomato the length of the circumference of your waist the mass of this piece of gold. the shape of your nose the shape of your nostril a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001]) If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001]) (forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001] (forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001] quality a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001]) If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001]) (forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001] (forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001] BFO:0000020 sdc SpecificallyDependentContinuant Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key of one-sided specifically dependent continuants: the mass of this tomato of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates. the disposition of this fish to decay the function of this heart: to pump blood the mutual dependence of proton donors and acceptors in chemical reactions [79 the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction the pink color of a medium rare piece of grilled filet mignon at its center the role of being a doctor the shape of this hole. the smell of this portion of mozzarella b is a relational specifically dependent continuant = Def. b is a specifically dependent continuant and there are n &gt; 1 independent continuants c1, … cn which are not spatial regions are such that for all 1 i &lt; j n, ci and cj share no common parts, are such that for each 1 i n, b s-depends_on ci at every time t during the course of b’s existence (axiom label in BFO2 Reference: [131-004]) b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003]) Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc. (iff (RelationalSpecificallyDependentContinuant a) (and (SpecificallyDependentContinuant a) (forall (t) (exists (b c) (and (not (SpatialRegion b)) (not (SpatialRegion c)) (not (= b c)) (not (exists (d) (and (continuantPartOfAt d b t) (continuantPartOfAt d c t)))) (specificallyDependsOnAt a b t) (specificallyDependsOnAt a c t)))))) // axiom label in BFO2 CLIF: [131-004] (iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003] specifically dependent continuant b is a relational specifically dependent continuant = Def. b is a specifically dependent continuant and there are n &gt; 1 independent continuants c1, … cn which are not spatial regions are such that for all 1 i &lt; j n, ci and cj share no common parts, are such that for each 1 i n, b s-depends_on ci at every time t during the course of b’s existence (axiom label in BFO2 Reference: [131-004]) b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003]) Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc. per discussion with Barry Smith (iff (RelationalSpecificallyDependentContinuant a) (and (SpecificallyDependentContinuant a) (forall (t) (exists (b c) (and (not (SpatialRegion b)) (not (SpatialRegion c)) (not (= b c)) (not (exists (d) (and (continuantPartOfAt d b t) (continuantPartOfAt d c t)))) (specificallyDependsOnAt a b t) (specificallyDependsOnAt a c t)))))) // axiom label in BFO2 CLIF: [131-004] (iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003] BFO:0000023 role Role John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married. the priest role the role of a boundary to demarcate two neighboring administrative territories the role of a building in serving as a military target the role of a stone in marking a property boundary the role of subject in a clinical trial the student role BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals – professor, sergeant, nurse – only during certain phases in their lives. b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001]) (forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001] role b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001]) (forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001] BFO:0000024 fiat-object FiatObjectPart or with divisions drawn by cognitive subjects for practical reasons, such as the division of a cake (before slicing) into (what will become) slices (and thus member parts of an object aggregate). However, this does not mean that fiat object parts are dependent for their existence on divisions or delineations effected by cognitive subjects. If, for example, it is correct to conceive geological layers of the Earth as fiat object parts of the Earth, then even though these layers were first delineated in recent times, still existed long before such delineation and what holds of these layers (for example that the oldest layers are also the lowest layers) did not begin to hold because of our acts of delineation.Treatment of material entity in BFOExamples viewed by some as problematic cases for the trichotomy of fiat object part, object, and object aggregate include: a mussel on (and attached to) a rock, a slime mold, a pizza, a cloud, a galaxy, a railway train with engine and multiple carriages, a clonal stand of quaking aspen, a bacterial community (biofilm), a broken femur. Note that, as Aristotle already clearly recognized, such problematic cases – which lie at or near the penumbra of instances defined by the categories in question – need not invalidate these categories. The existence of grey objects does not prove that there are not objects which are black and objects which are white; the existence of mules does not prove that there are not objects which are donkeys and objects which are horses. It does, however, show that the examples in question need to be addressed carefully in order to show how they can be fitted into the proposed scheme, for example by recognizing additional subdivisions [29 the FMA:regional parts of an intact human body. the Western hemisphere of the Earth the division of the brain into regions the division of the planet into hemispheres the dorsal and ventral surfaces of the body the upper and lower lobes of the left lung BFO 2 Reference: Most examples of fiat object parts are associated with theoretically drawn divisions b is a fiat object part = Def. b is a material entity which is such that for all times t, if b exists at t then there is some object c such that b proper continuant_part of c at t and c is demarcated from the remainder of c by a two-dimensional continuant fiat boundary. (axiom label in BFO2 Reference: [027-004]) (forall (x) (if (FiatObjectPart x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y) (and (Object y) (properContinuantPartOfAt x y t)))))))) // axiom label in BFO2 CLIF: [027-004] fiat object b is a fiat object part = Def. b is a material entity which is such that for all times t, if b exists at t then there is some object c such that b proper continuant_part of c at t and c is demarcated from the remainder of c by a two-dimensional continuant fiat boundary. (axiom label in BFO2 Reference: [027-004]) (forall (x) (if (FiatObjectPart x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y) (and (Object y) (properContinuantPartOfAt x y t)))))))) // axiom label in BFO2 CLIF: [027-004] BFO:0000026 1d-s-region OneDimensionalSpatialRegion an edge of a cube-shaped portion of space. A one-dimensional spatial region is a line or aggregate of lines stretching from one point in space to another. (axiom label in BFO2 Reference: [038-001]) (forall (x) (if (OneDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [038-001] one-dimensional spatial region A one-dimensional spatial region is a line or aggregate of lines stretching from one point in space to another. (axiom label in BFO2 Reference: [038-001]) (forall (x) (if (OneDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [038-001] BFO:0000027 object-aggregate ObjectAggregate a collection of cells in a blood biobank. a swarm of bees is an aggregate of members who are linked together through natural bonds a symphony orchestra an organization is an aggregate whose member parts have roles of specific types (for example in a jazz band, a chess club, a football team) defined by fiat: the aggregate of members of an organization defined through physical attachment: the aggregate of atoms in a lump of granite defined through physical containment: the aggregate of molecules of carbon dioxide in a sealed container defined via attributive delimitations such as: the patients in this hospital the aggregate of bearings in a constant velocity axle joint the aggregate of blood cells in your body the nitrogen atoms in the atmosphere the restaurants in Palo Alto your collection of Meissen ceramic plates. An entity a is an object aggregate if and only if there is a mutually exhaustive and pairwise disjoint partition of a into objects BFO 2 Reference: object aggregates may gain and lose parts while remaining numerically identical (one and the same individual) over time. This holds both for aggregates whose membership is determined naturally (the aggregate of cells in your body) and aggregates determined by fiat (a baseball team, a congressional committee). ISBN:978-3-938793-98-5pp124-158#Thomas Bittner and Barry Smith, 'A Theory of Granular Partitions', in K. Munn and B. Smith (eds.), Applied Ontology: An Introduction, Frankfurt/Lancaster: ontos, 2008, 125-158. b is an object aggregate means: b is a material entity consisting exactly of a plurality of objects as member_parts at all times at which b exists. (axiom label in BFO2 Reference: [025-004]) (forall (x) (if (ObjectAggregate x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y z) (and (Object y) (Object z) (memberPartOfAt y x t) (memberPartOfAt z x t) (not (= y z)))))) (not (exists (w t_1) (and (memberPartOfAt w x t_1) (not (Object w)))))))) // axiom label in BFO2 CLIF: [025-004] object aggregate An entity a is an object aggregate if and only if there is a mutually exhaustive and pairwise disjoint partition of a into objects An entity a is an object aggregate if and only if there is a mutually exhaustive and pairwise disjoint partition of a into objects ISBN:978-3-938793-98-5pp124-158#Thomas Bittner and Barry Smith, 'A Theory of Granular Partitions', in K. Munn and B. Smith (eds.), Applied Ontology: An Introduction, Frankfurt/Lancaster: ontos, 2008, 125-158. b is an object aggregate means: b is a material entity consisting exactly of a plurality of objects as member_parts at all times at which b exists. (axiom label in BFO2 Reference: [025-004]) (forall (x) (if (ObjectAggregate x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y z) (and (Object y) (Object z) (memberPartOfAt y x t) (memberPartOfAt z x t) (not (= y z)))))) (not (exists (w t_1) (and (memberPartOfAt w x t_1) (not (Object w)))))))) // axiom label in BFO2 CLIF: [025-004] BFO:0000028 3d-s-region ThreeDimensionalSpatialRegion a cube-shaped region of space a sphere-shaped region of space, A three-dimensional spatial region is a spatial region that is of three dimensions. (axiom label in BFO2 Reference: [040-001]) (forall (x) (if (ThreeDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [040-001] three-dimensional spatial region A three-dimensional spatial region is a spatial region that is of three dimensions. (axiom label in BFO2 Reference: [040-001]) (forall (x) (if (ThreeDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [040-001] BFO:0000029 site Site Manhattan Canyon) a hole in the interior of a portion of cheese a rabbit hole an air traffic control region defined in the airspace above an airport the Grand Canyon the Piazza San Marco the cockpit of an aircraft the hold of a ship the interior of a kangaroo pouch the interior of the trunk of your car the interior of your bedroom the interior of your office the interior of your refrigerator the lumen of your gut your left nostril (a fiat part – the opening – of your left nasal cavity) b is a site means: b is a three-dimensional immaterial entity that is (partially or wholly) bounded by a material entity or it is a three-dimensional immaterial part thereof. (axiom label in BFO2 Reference: [034-002]) (forall (x) (if (Site x) (ImmaterialEntity x))) // axiom label in BFO2 CLIF: [034-002] site b is a site means: b is a three-dimensional immaterial entity that is (partially or wholly) bounded by a material entity or it is a three-dimensional immaterial part thereof. (axiom label in BFO2 Reference: [034-002]) (forall (x) (if (Site x) (ImmaterialEntity x))) // axiom label in BFO2 CLIF: [034-002] BFO:0000030 object Object atom cell cells and organisms engineered artifacts grain of sand molecule organelle organism planet solid portions of matter star BFO 2 Reference: BFO rests on the presupposition that at multiple micro-, meso- and macroscopic scales reality exhibits certain stable, spatially separated or separable material units, combined or combinable into aggregates of various sorts (for example organisms into what are called ‘populations’). Such units play a central role in almost all domains of natural science from particle physics to cosmology. Many scientific laws govern the units in question, employing general terms (such as ‘molecule’ or ‘planet’) referring to the types and subtypes of units, and also to the types and subtypes of the processes through which such units develop and interact. The division of reality into such natural units is at the heart of biological science, as also is the fact that these units may form higher-level units (as cells form multicellular organisms) and that they may also form aggregates of units, for example as cells form portions of tissue and organs form families, herds, breeds, species, and so on. At the same time, the division of certain portions of reality into engineered units (manufactured artifacts) is the basis of modern industrial technology, which rests on the distributed mass production of engineered parts through division of labor and on their assembly into larger, compound units such as cars and laptops. The division of portions of reality into units is one starting point for the phenomenon of counting. BFO 2 Reference: Each object is such that there are entities of which we can assert unproblematically that they lie in its interior, and other entities of which we can assert unproblematically that they lie in its exterior. This may not be so for entities lying at or near the boundary between the interior and exterior. This means that two objects – for example the two cells depicted in Figure 3 – may be such that there are material entities crossing their boundaries which belong determinately to neither cell. Something similar obtains in certain cases of conjoined twins (see below). BFO 2 Reference: To say that b is causally unified means: b is a material entity which is such that its material parts are tied together in such a way that, in environments typical for entities of the type in question,if c, a continuant part of b that is in the interior of b at t, is larger than a certain threshold size (which will be determined differently from case to case, depending on factors such as porosity of external cover) and is moved in space to be at t at a location on the exterior of the spatial region that had been occupied by b at t, then either b’s other parts will be moved in coordinated fashion or b will be damaged (be affected, for example, by breakage or tearing) in the interval between t and t.causal changes in one part of b can have consequences for other parts of b without the mediation of any entity that lies on the exterior of b. Material entities with no proper material parts would satisfy these conditions trivially. Candidate examples of types of causal unity for material entities of more complex sorts are as follows (this is not intended to be an exhaustive list):CU1: Causal unity via physical coveringHere the parts in the interior of the unified entity are combined together causally through a common membrane or other physical covering\. The latter points outwards toward and may serve a protective function in relation to what lies on the exterior of the entity [13, 47 BFO 2 Reference: an object is a maximal causally unified material entity BFO 2 Reference: ‘objects’ are sometimes referred to as ‘grains’ [74 b is an object means: b is a material entity which manifests causal unity of one or other of the types CUn listed above & is of a type (a material universal) instances of which are maximal relative to this criterion of causal unity. (axiom label in BFO2 Reference: [024-001]) object b is an object means: b is a material entity which manifests causal unity of one or other of the types CUn listed above & is of a type (a material universal) instances of which are maximal relative to this criterion of causal unity. (axiom label in BFO2 Reference: [024-001]) BFO:0000031 gdc GenericallyDependentContinuant The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity. the pdf file on your laptop, the pdf file that is a copy thereof on my laptop the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule. b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001]) (iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001] generically dependent continuant b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001]) (iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001] BFO:0000034 function Function the function of a hammer to drive in nails the function of a heart pacemaker to regulate the beating of a heart through electricity the function of amylase in saliva to break down starch into sugar BFO 2 Reference: In the past, we have distinguished two varieties of function, artifactual function and biological function. These are not asserted subtypes of BFO:function however, since the same function – for example: to pump, to transport – can exist both in artifacts and in biological entities. The asserted subtypes of function that would be needed in order to yield a separate monoheirarchy are not artifactual function, biological function, etc., but rather transporting function, pumping function, etc. A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001]) (forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001] function A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001]) (forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001] BFO:0000035 p-boundary ProcessBoundary the boundary between the 2nd and 3rd year of your life. p is a process boundary =Def. p is a temporal part of a process & p has no proper temporal parts. (axiom label in BFO2 Reference: [084-001]) Every process boundary occupies_temporal_region a zero-dimensional temporal region. (axiom label in BFO2 Reference: [085-002]) (forall (x) (if (ProcessBoundary x) (exists (y) (and (ZeroDimensionalTemporalRegion y) (occupiesTemporalRegion x y))))) // axiom label in BFO2 CLIF: [085-002] (iff (ProcessBoundary a) (exists (p) (and (Process p) (temporalPartOf a p) (not (exists (b) (properTemporalPartOf b a)))))) // axiom label in BFO2 CLIF: [084-001] process boundary p is a process boundary =Def. p is a temporal part of a process & p has no proper temporal parts. (axiom label in BFO2 Reference: [084-001]) Every process boundary occupies_temporal_region a zero-dimensional temporal region. (axiom label in BFO2 Reference: [085-002]) (forall (x) (if (ProcessBoundary x) (exists (y) (and (ZeroDimensionalTemporalRegion y) (occupiesTemporalRegion x y))))) // axiom label in BFO2 CLIF: [085-002] (iff (ProcessBoundary a) (exists (p) (and (Process p) (temporalPartOf a p) (not (exists (b) (properTemporalPartOf b a)))))) // axiom label in BFO2 CLIF: [084-001] BFO:0000038 1d-t-region OneDimensionalTemporalRegion the temporal region during which a process occurs. BFO 2 Reference: A temporal interval is a special kind of one-dimensional temporal region, namely one that is self-connected (is without gaps or breaks). A one-dimensional temporal region is a temporal region that is extended. (axiom label in BFO2 Reference: [103-001]) (forall (x) (if (OneDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [103-001] one-dimensional temporal region A one-dimensional temporal region is a temporal region that is extended. (axiom label in BFO2 Reference: [103-001]) (forall (x) (if (OneDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [103-001] BFO:0000040 material MaterialEntity a flame a forest fire a human being a hurricane a photon a puff of smoke a sea wave a tornado an aggregate of human beings. an energy wave an epidemic the undetached arm of a human being BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60 BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity. BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here. A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002]) Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002]) every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002]) (forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002] (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002] (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002] material entity A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002]) Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002]) every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002]) (forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002] (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002] (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002] BFO:0000140 cf-boundary ContinuantFiatBoundary b is a continuant fiat boundary = Def. b is an immaterial entity that is of zero, one or two dimensions and does not include a spatial region as part. (axiom label in BFO2 Reference: [029-001]) BFO 2 Reference: In BFO 1.1 the assumption was made that the external surface of a material entity such as a cell could be treated as if it were a boundary in the mathematical sense. The new document propounds the view that when we talk about external surfaces of material objects in this way then we are talking about something fiat. To be dealt with in a future version: fiat boundaries at different levels of granularity.More generally, the focus in discussion of boundaries in BFO 2.0 is now on fiat boundaries, which means: boundaries for which there is no assumption that they coincide with physical discontinuities. The ontology of boundaries becomes more closely allied with the ontology of regions. BFO 2 Reference: a continuant fiat boundary is a boundary of some material entity (for example: the plane separating the Northern and Southern hemispheres; the North Pole), or it is a boundary of some immaterial entity (for example of some portion of airspace). Three basic kinds of continuant fiat boundary can be distinguished (together with various combination kinds [29 Continuant fiat boundary doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the mereological sum of two-dimensional continuant fiat boundary and a one dimensional continuant fiat boundary that doesn't overlap it. The situation is analogous to temporal and spatial regions. Every continuant fiat boundary is located at some spatial region at every time at which it exists (iff (ContinuantFiatBoundary a) (and (ImmaterialEntity a) (exists (b) (and (or (ZeroDimensionalSpatialRegion b) (OneDimensionalSpatialRegion b) (TwoDimensionalSpatialRegion b)) (forall (t) (locatedInAt a b t)))) (not (exists (c t) (and (SpatialRegion c) (continuantPartOfAt c a t)))))) // axiom label in BFO2 CLIF: [029-001] continuant fiat boundary b is a continuant fiat boundary = Def. b is an immaterial entity that is of zero, one or two dimensions and does not include a spatial region as part. (axiom label in BFO2 Reference: [029-001]) Continuant fiat boundary doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the mereological sum of two-dimensional continuant fiat boundary and a one dimensional continuant fiat boundary that doesn't overlap it. The situation is analogous to temporal and spatial regions. (iff (ContinuantFiatBoundary a) (and (ImmaterialEntity a) (exists (b) (and (or (ZeroDimensionalSpatialRegion b) (OneDimensionalSpatialRegion b) (TwoDimensionalSpatialRegion b)) (forall (t) (locatedInAt a b t)))) (not (exists (c t) (and (SpatialRegion c) (continuantPartOfAt c a t)))))) // axiom label in BFO2 CLIF: [029-001] BFO:0000141 immaterial ImmaterialEntity BFO 2 Reference: Immaterial entities are divided into two subgroups:boundaries and sites, which bound, or are demarcated in relation, to material entities, and which can thus change location, shape and size and as their material hosts move or change shape or size (for example: your nasal passage; the hold of a ship; the boundary of Wales (which moves with the rotation of the Earth) [38, 7, 10 immaterial entity BFO:0000142 1d-cf-boundary OneDimensionalContinuantFiatBoundary The Equator all geopolitical boundaries all lines of latitude and longitude the line separating the outer surface of the mucosa of the lower lip from the outer surface of the skin of the chin. the median sulcus of your tongue a one-dimensional continuant fiat boundary is a continuous fiat line whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [032-001]) (iff (OneDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (OneDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [032-001] one-dimensional continuant fiat boundary a one-dimensional continuant fiat boundary is a continuous fiat line whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [032-001]) (iff (OneDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (OneDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [032-001] BFO:0000144 process-profile ProcessProfile On a somewhat higher level of complexity are what we shall call rate process profiles, which are the targets of selective abstraction focused not on determinate quality magnitudes plotted over time, but rather on certain ratios between these magnitudes and elapsed times. A speed process profile, for example, is represented by a graph plotting against time the ratio of distance covered per unit of time. Since rates may change, and since such changes, too, may have rates of change, we have to deal here with a hierarchy of process profile universals at successive levels One important sub-family of rate process profiles is illustrated by the beat or frequency profiles of cyclical processes, illustrated by the 60 beats per minute beating process of John’s heart, or the 120 beats per minute drumming process involved in one of John’s performances in a rock band, and so on. Each such process includes what we shall call a beat process profile instance as part, a subtype of rate process profile in which the salient ratio is not distance covered but rather number of beat cycles per unit of time. Each beat process profile instance instantiates the determinable universal beat process profile. But it also instantiates multiple more specialized universals at lower levels of generality, selected from rate process profilebeat process profileregular beat process profile3 bpm beat process profile4 bpm beat process profileirregular beat process profileincreasing beat process profileand so on.In the case of a regular beat process profile, a rate can be assigned in the simplest possible fashion by dividing the number of cycles by the length of the temporal region occupied by the beating process profile as a whole. Irregular process profiles of this sort, for example as identified in the clinic, or in the readings on an aircraft instrument panel, are often of diagnostic significance. The simplest type of process profiles are what we shall call ‘quality process profiles’, which are the process profiles which serve as the foci of the sort of selective abstraction that is involved when measurements are made of changes in single qualities, as illustrated, for example, by process profiles of mass, temperature, aortic pressure, and so on. b is a process_profile =Def. there is some process c such that b process_profile_of c (axiom label in BFO2 Reference: [093-002]) b process_profile_of c holds when b proper_occurrent_part_of c& there is some proper_occurrent_part d of c which has no parts in common with b & is mutually dependent on b& is such that b, c and d occupy the same temporal region (axiom label in BFO2 Reference: [094-005]) (forall (x y) (if (processProfileOf x y) (and (properContinuantPartOf x y) (exists (z t) (and (properOccurrentPartOf z y) (TemporalRegion t) (occupiesSpatioTemporalRegion x t) (occupiesSpatioTemporalRegion y t) (occupiesSpatioTemporalRegion z t) (not (exists (w) (and (occurrentPartOf w x) (occurrentPartOf w z))))))))) // axiom label in BFO2 CLIF: [094-005] (iff (ProcessProfile a) (exists (b) (and (Process b) (processProfileOf a b)))) // axiom label in BFO2 CLIF: [093-002] process profile b is a process_profile =Def. there is some process c such that b process_profile_of c (axiom label in BFO2 Reference: [093-002]) b process_profile_of c holds when b proper_occurrent_part_of c& there is some proper_occurrent_part d of c which has no parts in common with b & is mutually dependent on b& is such that b, c and d occupy the same temporal region (axiom label in BFO2 Reference: [094-005]) (forall (x y) (if (processProfileOf x y) (and (properContinuantPartOf x y) (exists (z t) (and (properOccurrentPartOf z y) (TemporalRegion t) (occupiesSpatioTemporalRegion x t) (occupiesSpatioTemporalRegion y t) (occupiesSpatioTemporalRegion z t) (not (exists (w) (and (occurrentPartOf w x) (occurrentPartOf w z))))))))) // axiom label in BFO2 CLIF: [094-005] (iff (ProcessProfile a) (exists (b) (and (Process b) (processProfileOf a b)))) // axiom label in BFO2 CLIF: [093-002] BFO:0000145 r-quality RelationalQuality John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married. a marriage bond, an instance of love, an obligation between one person and another. b is a relational quality = Def. for some independent continuants c, d and for some time t: b quality_of c at t & b quality_of d at t. (axiom label in BFO2 Reference: [057-001]) (iff (RelationalQuality a) (exists (b c t) (and (IndependentContinuant b) (IndependentContinuant c) (qualityOfAt a b t) (qualityOfAt a c t)))) // axiom label in BFO2 CLIF: [057-001] relational quality 2 b is a relational quality = Def. for some independent continuants c, d and for some time t: b quality_of c at t & b quality_of d at t. (axiom label in BFO2 Reference: [057-001]) (iff (RelationalQuality a) (exists (b c t) (and (IndependentContinuant b) (IndependentContinuant c) (qualityOfAt a b t) (qualityOfAt a c t)))) // axiom label in BFO2 CLIF: [057-001] BFO:0000146 2d-cf-boundary TwoDimensionalContinuantFiatBoundary a two-dimensional continuant fiat boundary (surface) is a self-connected fiat surface whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [033-001]) (iff (TwoDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (TwoDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [033-001] two-dimensional continuant fiat boundary a two-dimensional continuant fiat boundary (surface) is a self-connected fiat surface whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [033-001]) (iff (TwoDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (TwoDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [033-001] BFO:0000147 0d-cf-boundary ZeroDimensionalContinuantFiatBoundary the geographic North Pole the point of origin of some spatial coordinate system. the quadripoint where the boundaries of Colorado, Utah, New Mexico, and Arizona meet zero dimension continuant fiat boundaries are not spatial points. Considering the example 'the quadripoint where the boundaries of Colorado, Utah, New Mexico, and Arizona meet' : There are many frames in which that point is zooming through many points in space. Whereas, no matter what the frame, the quadripoint is always in the same relation to the boundaries of Colorado, Utah, New Mexico, and Arizona. a zero-dimensional continuant fiat boundary is a fiat point whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [031-001]) (iff (ZeroDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (ZeroDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [031-001] zero-dimensional continuant fiat boundary zero dimension continuant fiat boundaries are not spatial points. Considering the example 'the quadripoint where the boundaries of Colorado, Utah, New Mexico, and Arizona meet' : There are many frames in which that point is zooming through many points in space. Whereas, no matter what the frame, the quadripoint is always in the same relation to the boundaries of Colorado, Utah, New Mexico, and Arizona. requested by Melanie Courtot a zero-dimensional continuant fiat boundary is a fiat point whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [031-001]) (iff (ZeroDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (ZeroDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [031-001] BFO:0000148 0d-t-region ZeroDimensionalTemporalRegion a temporal region that is occupied by a process boundary right now the moment at which a child is born the moment at which a finger is detached in an industrial accident the moment of death. temporal instant. A zero-dimensional temporal region is a temporal region that is without extent. (axiom label in BFO2 Reference: [102-001]) (forall (x) (if (ZeroDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [102-001] zero-dimensional temporal region A zero-dimensional temporal region is a temporal region that is without extent. (axiom label in BFO2 Reference: [102-001]) (forall (x) (if (ZeroDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [102-001] BFO:0000182 history History A history is a process that is the sum of the totality of processes taking place in the spatiotemporal region occupied by a material entity or site, including processes on the surface of the entity or within the cavities to which it serves as host. (axiom label in BFO2 Reference: [138-001]) history A history is a process that is the sum of the totality of processes taking place in the spatiotemporal region occupied by a material entity or site, including processes on the surface of the entity or within the cavities to which it serves as host. (axiom label in BFO2 Reference: [138-001]) CVDO:0000010 An endocarditis caused by bacterial infection. bacterial endocarditis CVDO:0000011 An endocarditis caused by viral infection. viral endocarditis CVDO:0000012 An endocarditis caused by fungal infection. fungal endocarditis CVDO:0000015 A disorder located in the heart. heart disorder CVDO:0000016 A disorder always located in a blood vessel. vascular disorder CVDO:0000020 A disorder always located in the endocardium. endocardium disorder CVDO:0000023 A disorder always located in the pericardium. Since the pericardium is not a part of the heart according to FMA, pericardium disorder is not classified as a heart disorder. pericardium disorder CVDO:0000033 A pericarditis caused by an infection. infectious pericarditis CVDO:0000034 A pericarditis caused by a bacterial infection. bacterial pericarditis CVDO:0000035 A pericarditis caused by a viral infection. viral pericarditis CVDO:0000036 A pericarditis caused by a fungal infection. fungal pericarditis CVDO:0000037 protozoal pericarditis CVDO:0000039 A pathological process involving or occuring in the heart. heart pathological process CVDO:0000040 A pathological process involving or occuring in the pericardium. pericardium pathological process CVDO:0000041 A pericarditis that has an acute disease course. acute pericarditis CVDO:0000042 A pericarditis that has a chronic disease course. chronic pericarditis CVDO:0000043 atrioventricular block (disease) CVDO:0000044 first degree atrioventricular block (disease) CVDO:0000045 Mobitz I second degree atrioventricular block (disease) CVDO:0000046 complete heart block third degree atrioventricular block (disease) CVDO:0000047 A disorder always loacted in the conducting tissue of the heart. heart conduction disorder CVDO:0000048 impaired atrioventricular node CVDO:0000051 impaired right branch of atrioventricular bundle CVDO:0000052 bundle of Kent CVDO:0000061 sinoatrial block (disease) CVDO:0000062 Wenckebach block Mobitz I second degree sinoatrial block (disease) CVDO:0000063 sinus exit block Mobitz II second degree sinoatrial block (disease) CVDO:0000064 first degree sinoatrial block (disease) CVDO:0000065 third degree sinoatrial block (disease) CVDO:0000066 impaired sinoatrial node CVDO:0000072 heart block (disease) CVDO:0000077 impaired posterior division of left branch of atrioventricular bundle CVDO:0000080 left posterior fascicular block (disease) CVDO:0000081 infra-hisian block (disease) CVDO:0000082 left bundle branch block (disease) CVDO:0000088 A heart conduction disease characterized by cardiac arrhythmia processes. Usual medical language does not differentiate the disease and the corresponding pathological process for the different kinds of cardiac arrhythmias. CVDO distinguishes them explicitly with the suffix '(disease)' or '(process)'. cardiac arrhythmia (disease) CVDO:0000092 atrial fibrillation (disease) CVDO:0000093 atrial fibrillation (process) CVDO:0000094 atrial flutter (disease) CVDO:0000097 cavotricuspid isthmus dependant macroreentry tachycardia type I atrial flutter common atrial flutter (disease) CVDO:0000110 A pathological process of fibrosis of the cardiac atrium. cardiac atrium fibrosis CVDO:0000111 supraventricular tachycardia (process) CVDO:0000139 bradycardia (disease) CVDO:0000140 bradycardia (process) CVDO:0000143 premature atrial contraction (disease) CVDO:0000144 left anterior fascicle CVDO:0000148 A disorder always located in a heart valve. heart valve disorder CVDO:0000153 wandering pacemaker CVDO:0000154 A disease affecting the tricuspid valve of the heart. tricuspid valve disease CVDO:0000156 A degenerated structure in a mitral valve leaflet due to myxomatous proliferation. myxomatous degenerated structure in a mitral valve leaflet CVDO:0000159 A heart pathological process that has a heart valve as a participant. This class should not be confused with 'heart valve pathological process', which are pathological processes occurring in a heart valve, rather than pathological process having as participant a heart valve. heart pathological process involving a heart valve CVDO:0000160 mitral valve leaflet displacement into the left atrium during left ventricular systole CVDO:0000162 tricuspid valve leaflet displacement into the right atrium during right ventricular systole CVDO:0000163 aortic valve leaflet displacement into the left ventricle during left ventricular diastole CVDO:0000164 heart valve leaflet displacement into a cardiac chamber during ventricular systole CVDO:0000166 mitral valve improper close during left ventricular systole CVDO:0000168 retrograd blood flow through mitral valve during left ventricular systole CVDO:0000169 retrograd blood flow through pulmonary valve during right ventricular diastole CVDO:0000170 pulmonary valve improper close during right ventricular diastole CVDO:0000171 tricuspid valve improper close during right ventricular systole CVDO:0000172 aortic valve improper close during left ventricular diastole CVDO:0000173 retrograd blood flow through tricuspid valve during right ventricular systole CVDO:0000175 retrograd blood flow through aortic valve during left ventricular diastole CVDO:0000181 disturbed anterograd blood flow through mitral valve during left ventricular diastole CVDO:0000182 retrograd blood flow through a heart valve CVDO:0000183 disturbed anterograd blood flow through a heart valve CVDO:0000184 disturbed anterograd blood flow through tricuspid valve during right ventricular diastole CVDO:0000186 disturbed anterograd blood flow through pulmonary valve during right ventricular systole CVDO:0000187 disturbed anterograd blood flow through aortic valve during left ventricular systole CVDO:0000189 A disease in which some disorder of a heart valve prevents it from opening properly, occasioning disturbance in the anterograd blood flow through the valve. heart valve stenosis CVDO:0000191 impaired cardiac output CVDO:0000193 pressure CVDO:0000194 blood pressure CVDO:0000196 A pathological process of highly pressured aerterial blood flow. highly pressured arterial blood flow CVDO:0000209 A disease in which an abnormal structure in a heart valve prevents it to close propertly, occasioning a retrograd blood flow through the valve. heart valve insufficiency CVDO:0000210 A pathological process of a heart valve closing improperly. heart valve improper close CVDO:0000214 A disorder always located in a vein. vein disorder CVDO:0000216 A pathological process involving or occuring in a blood vessel. vascular pathological process CVDO:0000217 A pathological process of formation of a blood clot inside a blood vessel, obstructing the flow of blood. thrombosis CVDO:0000220 A thrombosis occurring in a deep vein. deep vein thrombosis CVDO:0000223 A pathological process of an artery hardening. artery hardening CVDO:0000224 A pathological process of formation of atheromous plaques in an artery. atheromous plaque formation in artery CVDO:0000225 A pathological process of lodging of an embolus in a blood vessel. embolism CVDO:0000226 A disorder of localized, blood-filled balloon-like bulge in the wall of a blood vessel. aneurysm (disorder) CVDO:0000231 ischemic disease CVDO:0000234 compression disease CVDO:0000238 An atrial fibrillation disease that is characterized by an atrial fibrillation episode longer than 7 days which does not terminate by cardioversion. permanent atrial fibrillation CVDO:0000239 A pathological process of dilatation of the myocardium of a right cardiac ventricle. right ventricular myocardium dilatation CVDO:0000240 A pathological process of an aneurysm rupturing. aneurysm rupture CVDO:0000248 A disorder always located in the mycoardium. myocardium disorder CVDO:0000254 A cardiomyopathy whose etiological process includes a stressful or emotional situation, characterized by transient ventricular apical wall motion abnormalities (ballooning). Tako-Tsubo cardiomyopathy is not a dilated cardiomyopathy in Elliott et al.'s (2008) classification. Tako Tsubo cardiomyopathy CVDO:0000255 "A cardiomyopathy characterized by prominent left ventricular trabeculae and deep inter-trabecular recesses. The myocardial wall is often thickened with a thin, compacted epicardial layer and a thickened endocardial layer." (Elliott et al., 2008) noncompaction cardiomyopathy left ventricular noncompaction CVDO:0000256 A hypertrophic cardiomyopathy that has a genetic origin. genetic hypertrophic cardiomyopathy CVDO:0000262 A disease affecting the pericardium. Since pericardium is not a part of heart according to FMA, pericardium disease is not classified as a heart disease. pericardium disease CVDO:0000267 This is a dummy class not intended to be included in CVDO's final version, used to store temporarily DOID's vascular diseases that may be reclassified in the future. vascular disease - unclassified by CVDO CVDO:0000273 A pathological process occuring in a cardiac atrium. cardiac atrium pathological process CVDO:0000274 A pathological process occurring in a cardiac ventricle. cardiac ventricle pathological process CVDO:0000275 A pathological process constituted by a thrombosis (creating a blood clot) and a subsequent embolism (involving the blood clot as the embolus). thromboembolism CVDO:0000276 A necrosis of a tissue caused by a local lack of oxygen, due to an obstruction of the tissue's blood supply. infarction CVDO:0000277 pulmonary valve leaflet displacement into the right ventricle during right ventricular diastole CVDO:0000279 A pathological process involving the blood circuation in the heart. cardiac blood circulation pathological process CVDO:0000280 A pathological process involving the blood circulation in a blood vessel. vascular blood circulation pathological process CVDO:0000281 part of atrial myocardium with impaired conduction CVDO:0000284 diabetic microangiopathy CVDO:0000285 diabetic macroangiopathy CVDO:0000288 A pathological process consisting in the formation of atheromous plaques in a coronary artery. It may lead to a coronary stenosis. atheromous plaque formation in coronary artery CVDO:0000293 A coronary heart disease due to a coronary stenosis. atherosclerotic coronary heart disease CVDO:0000294 A pathological process of dilatation of the myocardium of a left cardiac ventricle. left ventricular myocardium dilatation CVDO:0000296 supraventricular tachycardia (disease) CVDO:0000298 left atrial flutter (disease) CVDO:0000299 right atrial flutter (disease) CVDO:0000301 junctional tachycardia (disease) CVDO:0000304 atrioventricular nodal reentrant tachycardia (disease) CVDO:0000306 atrial flutter (process) CVDO:0000307 ventricular fibrillation (process) CVDO:0000308 junctional tachycardia (process) CVDO:0000309 premature atrial contraction (process) CVDO:0000310 A pathological process involving the electrical activity of the heart. cardiac arrhythmia (process) CVDO:0000311 heart block (process) CVDO:0000312 atrioventricular block (process) CVDO:0000313 infra-hisian block (process) CVDO:0000314 sinoatrial block (process) CVDO:0000315 Mobitz I second degree atrioventricular block (process) CVDO:0000316 Mobitz II second degree atrioventricular block (process) CVDO:0000317 first degree atrioventricular block (process) CVDO:0000318 third degree atrioventricular block (process) CVDO:0000319 left anterior fascicular block (process) CVDO:0000320 left bundle branch block (process) CVDO:0000321 left posterior fascicular block (process) CVDO:0000322 right bundle branch block (process) CVDO:0000323 Mobitz I second degree sinoatrial block (process) CVDO:0000324 Mobitz II second degree sinoatrial block (process) CVDO:0000325 first degree sinoatrial block (process) CVDO:0000326 third degree sinoatrial block (process) CVDO:0000327 A disorder always located in a coronary artery. coronary artery disorder CVDO:0000330 A pathological process of dilatation of the myocardium of a cardiac ventricle. ventricular myocardium dilatation CVDO:0000331 A pathological process of hypertrophy of the myocardium of a cardiac ventricle. ventricular myocardium hypertrophy CVDO:0000332 A pathological process of hypertrophy of the myocardium of a left cardiac ventricle. left ventricular myocardium hypertrophy CVDO:0000333 A pathological process of hypertrophy of the myocardium of a right cardiac ventricle. right ventricular myocardium hypertrophy CVDO:0000403 A pathological process of an organ or part of organ getting inflamed. pathological inflammation process CVDO:0000404 An inflammation process occurring in the myocardium. inflammation process in a myocardium CVDO:0000405 An inflammation process occurring in the endocardium. inflammation process in an endocardium CVDO:0000406 An inflammation process occurring in the pericardium. inflammation process in a pericardium CVDO:0000407 An inflammation process occurring in the aorta. inflammation process in aorta CVDO:0000408 An inflammation process in a blood vessel. inflammation process in a blood vessel CVDO:0000409 An inflammation process occurring in the femoral vein. inflammation process in a femoral vein CVDO:0000410 An inflammation process occurring in an iliac vein. inflammation process in an iliac vein CVDO:0000411 An inflammation of the retinal artery. inflammation process in a retinal artery CVDO:0000412 An inflammation process occurring in a vein. inflammation process in a vein CVDO:0000418 A pathological process of fibrofatty replacement in the myocardium of the right cardiac ventricle. fibrofatty replacement in a right ventricular myocardium CVDO:0000420 A disorder of degenerated structure in a heart valve leaflet. degenerated structure in a heart valve leaflet CVDO:0000421 A disorder of degenerated structure in an aortic valve leaflet. degenerated structure in an aortic valve leaflet CVDO:0000422 A disorder of degenerated structure in a mitral valve leaflet. degenerated structure in a mitral valve leaflet CVDO:0000423 A (clinically abnormal) degenerated structure in a tricuspid valve leaflet. degenerated structure in a tricuspid valve leaflet CVDO:0000424 A disorder of degenerated structure in a pulmonary valve leaflet. degenerated structure in a pulmonary valve leaflet CVDO:0000426 A mitral valve prolapse due to myxomatous proliferation in the mitral valve. Barlow's syndrome CVDO:0000427 A pathological process consisting in the abnormal accumulation of fluid in the pericardial cavity. A process of pericardial effusion leads to the disorder 'fluid in the pericardial cavity'. fluid accumulation in the pericardial cavity CVDO:0000435 An ischemic cardiomyopathy due to coronary stenosis. atherosclerotic ischemic cardiomyopathy CVDO:0000436 An atrial fibrillation disease that is characterized by an atrial fibrillation episode shorter than 7 days. paroxysmal atrial fibrillation CVDO:0000437 An atrial fibrillation disease that is characterized by an atrial fibrillation episode longer than 7 days which does terminate by cardioversion. persistent atrial fibrillation CVDO:0000439 premature contraction (process) CVDO:0000441 premature junctional contraction (process) CVDO:0000442 premature ventricular contraction (process) CVDO:0000443 sinus pause sinoatrial arrest (process) CVDO:0000444 sinus bradycardia (process) CVDO:0000445 tachyarrhythmia (process) tachycardia (process) CVDO:0000447 left atrial flutter (process) CVDO:0000448 right atrial flutter (process) CVDO:0000449 common atrial flutter (process) CVDO:0000450 atrioventricular nodal reentrant tachycardia (process) CVDO:0000453 ventricular tachycardia (process) CVDO:0000454 monomorphic ventricular tachycardia (process) CVDO:0000455 torsades de pointes (process) CVDO:0000456 ventricular flutter (process) CVDO:0000457 inappropriate sinus tachycardia (process) CVDO:0000458 ventricular preexcitation (process) CVDO:0000459 A pathological process of a coronary artery hardening. coronary artery hardening CVDO:0000462 accessory bundle CVDO:0000463 Accessory bundle that connects the atrium to a ventricle outside of the regular atrioventricular conduction system. atrioventricular accessory bundle CVDO:0000466 impaired sinus node CVDO:0000470 A sick sinus syndrome characterized by sinus pauses and/or bradycardia episodes alternating with sinus or atrial tachycardia episodes. tachycardia-bradycardia syndrome CVDO:0000471 inappropriate sinus tachycardia (disease) CVDO:0000472 A disease cause by a cardiac ion channel disorder. cardiac channelopathy CVDO:0000473 A cardiac channelopathy in which delayed repolarization of the heart following a heartbeat increases the risk of episodes of torsades de pointes. This is a rare disease. long QT syndrome CVDO:0000474 A cardiac channelopathy that has a genetic origin. genetic cardiac channelopathy CVDO:0000475 sinus bradycardia (disease) CVDO:0000476 left bundle branch block (process) CVDO:0000477 tachyarrhythmia (disease) tachycardia (disease) CVDO:0000479 sinoatrial arrest (disease) CVDO:0000480 atrioventricular reciprocating tachycardia (disease) CVDO:0000481 ventricular tachycardia (disease) CVDO:0000484 ventricular flutter (disease) CVDO:0000485 torsades de pointes (disease) CVDO:0000486 monomorphic ventricular tachycardia (disease) CVDO:0000487 ventricular fibrillation (disease) CVDO:0000489 ventricular tachyarrhythmia (process) CVDO:0000490 atrioventricular reciprocating tachycardia (process) CVDO:0000493 premature contraction (disease) CVDO:0000495 premature junctional contraction (disease) CVDO:0000496 premature ventricular contraction (disease) CVDO:0000497 A pathological process occurring in a cardiac chamber. cardiac chamber pathological process CVDO:0000499 A disorder always located in the mitral valve. mitral valve disorder CVDO:0000500 A disorder always located in the aortic valve. aortic valve disorder CVDO:0000501 A disorder always located in the tricuspid valve. tricuspid valve disorder CVDO:0000502 A disorder always located in the pulmonary valve. pulmonary valve disorder CVDO:0000503 A pathological process of a heart valve improper opening. heart valve improper opening CVDO:0000504 aortic valve improper opening during left ventricular systole CVDO:0000505 mitral valve narrowed opening during left ventricular diastole CVDO:0000506 pulmonary valve narrowed opening during right ventricular systole CVDO:0000507 tricuspid valve narrowed opening during right ventricular diastole CVDO:0000508 A coronary heart disease leading to stable angina. coronary heart disease with stable angina CVDO:0000509 An acute coronary syndrome due to coronary stenosis. atherosclerotic acute coronary syndrome CVDO:0000510 A heart ischemia accompanied by pain. Angina pectoris is sometimes taken to refer to the pain itself, rather than to the pathological process behind it. angina pectoris CVDO:0000511 An angina that is not unstable. stable angina pectoris CVDO:0000512 An angina that worsens. It has at least one of these three features: 1. it occurs at rest (or with minimal exertion), usually lasting >10 min 2. it is severe and of new onset (i.e., within the prior 4–6 weeks) 3. it occurs with a crescendo pattern (i.e., distinctly more severe, prolonged, or frequent than before). unstable angina pectoris CVDO:0000513 A heart pathological process that has a mitral valve as a participant. heart pathological process involving a mitral valve CVDO:0000514 A heart pathological process that has an aortic valve as a participant. heart pathological process involving an aortic valve CVDO:0000515 A heart pathological process that has a tricuspid valve as a participant. heart pathological process involving a tricuspid valve CVDO:0000516 A heart pathological process that has a pulmonary valve as a participant. heart pathological process involving a pulmonary valve CVDO:0000517 heart valve leaflet displacement into a cardiac chamber during ventricular diastole CVDO:0000518 ventricular systole CVDO:0000519 ventricular diastole CVDO:0000520 atrial systole CVDO:0000521 atrial diastole CVDO:0000522 left ventricular diastole CVDO:0000523 right ventricular diastole CVDO:0000524 left ventricular systole CVDO:0000525 right ventricular systole CVDO:0000526 left atrial systole CVDO:0000527 right atrial systole CVDO:0000528 left atrial diastole CVDO:0000529 right atrial diastole CVDO:0000530 A pathological process of a heart valve being displaced into a cardiac chamber. heart valve leaflet displacement into a cardiac chamber CVDO:0000531 A disorder of fluid in the pericardial cavity. fluid in the pericardial cavity CVDO:0000532 A disorder of blood in the pericardial cavity. blood in the pericardial cavity CVDO:0000534 heart conduction pathological process CVDO:0000535 anomalous atrioventricular excitation (process) CVDO:0000536 ventricular preexcitation (disease) CVDO:0000537 A disorder in the heart conduction system that causes a disturbed function of ion channel subunits or the proteins that regulate them. cardiac ion channels disorder CVDO:0000538 A disease characterized by the displacement of a degenerated pulmonary valve leaflet into the right ventricle during diastole. pulmonary valve prolapse CVDO:0000539 impaired anterior division of left branch of atrioventricular bundle CVDO:0000540 ventricular tachyarrhythmia (disease) CVDO:0000541 An inflammation process occurring in a heart valve. inflammation process in a heart valve CVDO:0000542 heart bodily process CVDO:0000543 A dilated cardiomyopathy that has a genetic origin. genetic dilated cardiomyopathy CVDO:0000544 A cardiomyopathy (2008) that has a genetic origin. genetic cardiomyopathy CVDO:0000545 A disorder made of a detached, traveling intravascular matter (solid, liquid, or gaseous) carried by circulation. It is capable of creating an arterial occlusion at a site distant from its point of origin. embolus CVDO:0000546 A disease characterized by an inflammation process. inflammatory disease CVDO:0000547 A pathological process occurring in the myocardium. myocardium pathological process CVDO:0000548 A pathological process involving or occuring in the aorta. aorta pathological process CVDO:0000549 A disorder always located in the aorta. aorta disorder CVDO:0000550 A pathological process occuring in the endocardium. endocardium pathological process CVDO:0000551 A pathological process of thickening of the endocardium. endocardium thickening CVDO:0000552 A disease affecting the endocardium. endocardium disease CVDO:0000553 A disorder always located in the left heart ventricle. left ventricle disorder CVDO:0000554 A disorder always located in the right heart ventricle. right ventricle disorder CVDO:0000555 A disorder always located in a heart ventricle. heart ventricle disorder CVDO:0000556 An ischemia of the heart. heart ischemia CVDO:0000557 vein pathological process CVDO:0000558 An ischemic heart disease leading to a dilatation and dysfunction of the left ventricle. ischemic cardiomyopathy CVDO:0000559 A disorder located in an anatomical entity. material anatomical entity disorder CVDO:0000560 material anatomical entity pathological process CVDO:0000562 cardiovascular system disorder CVDO:0000563 cardiovascular system pathological process CVDO:0000564 A disease that affects a material anatomical entity. disease of material anatomical entity CVDO:0000567 An aortic valve stenosis leading to a hypertrophy or dilatation of the left ventricle and its dysfunction. valvular cardiomyopathy CVDO:0000569 A heart disease in which the heart muscle is structurally and functionally abnormal, in the absence of coronary artery disease, hypertension, valvular disease and congenital heart disease sufficient to cause the observed myocardial abnormality. (adapted from Elliott et al., 2008, European Heart Journal, 29, 270-276) Contemporary (e.g. Elliott et al. 2008) definitions of cardiomyopathy exclude ischemic cardiomyopathy, hypertensive cardiomyopathy and valvular cardiomyopathy. cardiomyopathy (2008 definition) CVDO:0000570 left ventricular myocardium contraction dysfunctional process CVDO:0000571 myocardium contraction dysfunctional process CVDO:0000575 A pathological process occurring in the left heart ventricle. left ventricle pathological process CVDO:0000576 A pathological process occurring in the right heart ventricle. right ventricle pathological process CVDO:0000577 "Inflammatory DCM is defined by the presence of chronic inflammatory cells in association with left ventricular dilatation and reduced ejection fraction". (Elliott et al., 2008) inflammatory dilated cardiomyopathy inflammatory dilated cardiomyopathy CVDO:0000578 A hypertensive heart disease leading to a hypertrophy and dysfunction of the left ventricle. hypertensive cardiomyopathy CVDO:0000579 A heart disease existing at birth, or developping during the first month after birth. congenital heart disease CVDO:0000580 A disease affecting a heart ventricle. heart ventricle disease CVDO:0000581 A disease affecting a heart left ventricle. left ventricle disease CVDO:0000582 A disease affecting a heart right ventricle. right ventricle disease CVDO:0000583 ventricular myocardium contraction dysfunctional process CVDO:0000584 right ventricular myocardium contraction dysfunctional process CVDO:0000585 myocardium of left ventricle stiffening CVDO:0000586 A pathological process occurring in a heart valve. heart valve pathological process CVDO:0000587 A pathological process occurring in an aortic valve. aortic valve pathological process CVDO:0000588 A pathological process occurring in a mitral valve. mitral valve pathological process CVDO:0000589 A pathological process occurring in a tricuspid valve. tricuspid valve pathological process CVDO:0000590 A pathological process occurring in a pulmonary valve. pulmonary valve pathological process CVDO:0000591 A disease affecting the myocardium. myocardium disease CVDO:0000596 A heart disease that has a genetic disorder. genetic heart disease CVDO:0000597 A disease existing at birth, or developping during the first month after birth. congenital disease CVDO:0000599 coronary artery pathological process CVDO:0000600 A pathological process of coronary artery smooth muscle constriction. coronary artery smooth muscle constriction disease_ontology DOID:0000405 vascular tissue disease DOID:0000405 A cardiomyopathy characterized by adipose and fibrosis infiltration in the right ventricular myocardium. It is caused by genetic defects of desmosomes (which are parts of the myocardium) and may result in arrhythmia. MSH:D019571 OMIM:107970 OMIM:600996 OMIM:604400 OMIM:607450 OMIM:609040 OMIM:610193 OMIM:610476 OMIM:611528 ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY 1 ARVD arrhythmogenic right ventricular dysplasia/cardiomyopathy disease_ontology DOID:0050431 OMIM mapping confirmed by DO. [SN]. arrhythmogenic right ventricular dysplasia DOID:0050431 A heart conduction disease that is characterised by abnormal electrocardiogram (ECG) findings and an increased risk of sudden cardiac death by ventricular tachyarrhytmia. A heart conduction disease that is characterised by abnormal electrocardiogram (ECG) findings and an increased risk of sudden cardiac death. MSH:D053840 OMIM:601144 OMIM:611777 OMIM:611875 OMIM:611876 OMIM:612838 OMIM:613119 OMIM:613120 OMIM:613123 disease_ontology DOID:0050451 OMIM mapping confirmed by DO. [SN]. Brugada syndrome DOID:0050451 OMIM:208000 IDIOPATHIC INFANTILE ARTERIAL CALCIFICATION disease_ontology DOID:0050644 OMIM mapping confirmed by DO. [SN]. generalized arterial calcification of infancy DOID:0050644 OMIM:208050 disease_ontology DOID:0050645 OMIM mapping confirmed by DO. [SN]. arterial tortuosity syndrome DOID:0050645 An atrial fibrillation disease that has a genetic origin. A heart conduction disease that is characterized by uncoordinated electrical activity in the heart's upper chambers (the atria), which causes the heartbeat to become fast and irregular and has_material_basis_in autosomal dominant inheritance of the familial atrial fibrillation (ATFB) genes. OMIM:607554 OMIM:611493 OMIM:612201 OMIM:612240 disease_ontology DOID:0050650 familial atrial fibrillation DOID:0050650 Disease of the myocardium associated with cardiac dysfunction. (Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of Cardiomyopathies) DOID label "cardiomyopathy" was changed. A heart disease that is characterized by deterioration of the funciton of the heart muscle. lschriml 2012-01-03T02:54:11Z disease_ontology DOID:0050700 cardiomyopathy (1995 definition) DOID:0050700 An endocarditis caused by infection. A heart disease involving inflammation of the endocardium (inner layer of the heart) caused by bacterial infection. disease_ontology DOID:0060000 infective endocarditis DOID:0060000 An non-infective endocarditis that results in the deposition of small sterile vegetations on valve leaflets. DOID label 'marantic endocarditis' was changed in CVDO (non-bacterial thrombotic endocarditis is a more common name). lschriml 2011-04-13T03:14:26Z marantic endocarditis disease_ontology DOID:0060068 non-bacterial thrombotic endocarditis DOID:0060068 ICD9CM:434 ICD9CM:434.9 SNOMEDCT_2010_1_31:155400001 SNOMEDCT_2010_1_31:155403004 SNOMEDCT_2010_1_31:195188006 SNOMEDCT_2010_1_31:20059004 SNOMEDCT_2010_1_31:266255008 SNOMEDCT_2010_1_31:286956007 UMLS_CUI:C0028790 disease_ontology DOID:10127 cerebral artery occlusion DOID:10127 ICD9CM:459.81 MSH:D014689 SNOMEDCT_2010_1_31:20696009 UMLS_CUI:C0042485 peripheral venous insufficiency disease_ontology DOID:10128 venous insufficiency DOID:10128 SNOMEDCT_2010_1_31:65443008 UMLS_CUI:C0155593 disease_ontology DOID:10177 malignant hypertensive renal disease DOID:10177 ICD9CM:440.0 SNOMEDCT_2010_1_31:155415000 SNOMEDCT_2010_1_31:195252007 SNOMEDCT_2010_1_31:81817003 UMLS_CUI:C0155733 Aortic atherosclerosis Atherosclerosis of aorta (disorder) disease_ontology DOID:10230 aortic atherosclerosis DOID:10230 ICD9CM:115.93 SNOMEDCT_2010_1_31:187059008 UMLS_CUI:C0153279 Histoplasmosis with pericarditis (disorder) disease_ontology DOID:10234 histoplasmosis pericarditis DOID:10234 ICD9CM:410.7 UMLS_CUI:C0155655 disease_ontology DOID:10266 subendocardial infarction acute myocardial infarction DOID:10266 DOID label changed to 'left anterior fascicular block (disease)' for symmetry reasons with 'left posterior fascicular block (disease)' ICD9CM:426.2 SNOMEDCT_2010_1_31:195044001 SNOMEDCT_2010_1_31:195045000 SNOMEDCT_2010_1_31:266245009 SNOMEDCT_2010_1_31:4973001 UMLS_CUI:C0155702 Left bundle branch [block] or [hemiblock] Left bundle branch hemiblock (disorder) Left bundle branch hemiblock NOS (disorder) left bundle branch hemiblock disease_ontology DOID:10272 left anterior fascicular block (disease) DOID:10272 A disease affecting the conducting tissue of the heart. A heart disease that involves the heart's electrical conduction system. ICD9CM:426.6 SNOMEDCT_2010_1_31:195053008 SNOMEDCT_2010_1_31:195056000 UMLS_CUI:C0029630 disease_ontology DOID:10273 heart conduction disease DOID:10273 ICD9CM:443.0 MSH:D011928 NCI:C34972 OMIM:179600 SNOMEDCT_2010_1_31:123266007 SNOMEDCT_2010_1_31:155429004 SNOMEDCT_2010_1_31:195294005 SNOMEDCT_2010_1_31:195295006 SNOMEDCT_2010_1_31:195297003 SNOMEDCT_2010_1_31:22954002 SNOMEDCT_2010_1_31:266319002 UMLS_CUI:C0034734 Raynaud's disease Raynaud's disease (disorder) Raynaud's syndrome Raynaud's syndrome (disorder) Raynaud's syndrome (disorder) [Ambiguous] Raynaud's syndrome NOS (disorder) disease_ontology DOID:10300 OMIM mapping confirmed by DO. [SN]. Raynaud disease DOID:10300 A disease characterized by an inflammation of the endocardium. A heart disease involving non-infectious inflammation of the endocardium (inner layer of the heart). DOID:14058 MSH:D004696 NCI:C34582 SNOMEDCT_2010_1_31:194935007 SNOMEDCT_2010_1_31:56819008 SNOMEDCT_2010_1_31:91357005 UMLS_CUI:C0014118 UMLS_CUI:C0375268 disease_ontology DOID:10314 endocarditis DOID:10314 DOID label 'anomalous atrioventricular excitation' was changed. ICD9CM:426.7 SNOMEDCT_2010_1_31:155360000 SNOMEDCT_2010_1_31:17869006 SNOMEDCT_2010_1_31:195057009 SNOMEDCT_2010_1_31:195061003 SNOMEDCT_2010_1_31:266304003 UMLS_CUI:C0392470 Anomalous A-V excitation disease_ontology DOID:10392 anomalous atrioventricular excitation (disease) DOID:10392 ICD9CM:411.0 SNOMEDCT_2010_1_31:66189004 UMLS_CUI:C0152107 Postmyocardial infarction syndrome Postmyocardial infarction syndrome (disorder) disease_ontology DOID:10507 Dressler's syndrome DOID:10507 DOID:10555 DOID:12413 ICD9CM:669.20 UMLS_CUI:C0157456 antepartum maternal hypotension syndrome postpartum maternal hypotension syndrome disease_ontology DOID:10556 supine hypotensive syndrome DOID:10556 ICD9CM:642.40 UMLS_CUI:C0156664 disease_ontology DOID:10590 mild pre-eclampsia DOID:10590 DOID:12684 MSH:D011225 NCI:C34943 NCI:C85021 OMIM:189800 OMIM:609404 SNOMEDCT_2010_1_31:15394000 SNOMEDCT_2010_1_31:156106005 SNOMEDCT_2010_1_31:156109003 SNOMEDCT_2010_1_31:156112000 SNOMEDCT_2010_1_31:198969004 SNOMEDCT_2010_1_31:198972006 SNOMEDCT_2010_1_31:198979002 SNOMEDCT_2010_1_31:199011002 SNOMEDCT_2010_1_31:237280005 SNOMEDCT_2010_1_31:267306006 SNOMEDCT_2010_1_31:267307002 SNOMEDCT_2010_1_31:288201007 SNOMEDCT_2010_1_31:30354006 SNOMEDCT_2010_1_31:308551004 SNOMEDCT_2010_1_31:398254007 SNOMEDCT_2010_1_31:46764007 SNOMEDCT_2010_1_31:48194001 SNOMEDCT_2010_1_31:6758009 UMLS_CUI:C0032914 UMLS_CUI:C0340274 Gestational hypertension Gestational hypertension (disorder) PREECLAMPSIA/ECLAMPSIA Pre-eclampsia (disorder) Pre-eclampsia NOS Pre-eclampsia NOS (disorder) Pre-eclamptic NOS Pre-eclamptic toxaemia Pregnancy associated hypertension Pregnancy-induced hypertension (disorder) Proteinuric hypertension of pregnancy Toxaemia NOS Toxaemia of pregnancy Toxemia NOS (disorder) Toxemia of Pregnancy Toxemia of pregnancy (disorder) hypertension induced by pregnancy hypertension of preg. hypertension of pregnancy NOS hypertension of pregnancy NOS (disorder) preeclampsia pregnancy toxemia disease_ontology DOID:10591 OMIM mapping confirmed by DO. [SN]. pre-eclampsia DOID:10591 ICD9CM:708.0 SNOMEDCT_2010_1_31:156428000 SNOMEDCT_2010_1_31:201260002 SNOMEDCT_2010_1_31:40178009 UMLS_CUI:C0149526 Allergic urticaria (disorder) disease_ontology DOID:10612 allergic urticaria DOID:10612 ICD9CM:410.30 UMLS_CUI:C0155640 disease_ontology DOID:10648 acute inferoposterior infarction DOID:10648 ICD9CM:410.20 UMLS_CUI:C0155636 disease_ontology DOID:10649 acute inferolateral myocardial infarction DOID:10649 ICD9CM:410.0 SNOMEDCT_2010_1_31:70211005 UMLS_CUI:C0155627 disease_ontology DOID:10651 acute anterolateral myocardial infarction DOID:10651 MSH:D006977 NCI:C3121 SNOMEDCT_2010_1_31:194775007 SNOMEDCT_2010_1_31:28119000 UMLS_CUI:C0020544 disease_ontology DOID:1073 renal hypertension DOID:1073 ICD9CM:572.3 MSH:D006975 NCI:C3119 SNOMEDCT_2010_1_31:155821005 SNOMEDCT_2010_1_31:34742003 UMLS_CUI:C0020541 disease_ontology DOID:10762 portal hypertension DOID:10762 ICD9CM:401-405.99 ICD9CM:997.91 MSH:D006973 NCI:C3117 SNOMEDCT_2010_1_31:155295004 SNOMEDCT_2010_1_31:155302005 SNOMEDCT_2010_1_31:194756002 SNOMEDCT_2010_1_31:194757006 SNOMEDCT_2010_1_31:194760004 SNOMEDCT_2010_1_31:194794002 SNOMEDCT_2010_1_31:195537001 SNOMEDCT_2010_1_31:266287006 SNOMEDCT_2010_1_31:38341003 UMLS_CUI:C0020538 HTN High blood pressure (& [essential hypertension]) hyperpiesia vascular hypertensive disorder disease_ontology hypertensive disease DOID:10763 hypertension DOID:10763 ICD9CM:422.91 SNOMEDCT_2010_1_31:194954007 SNOMEDCT_2010_1_31:194955008 SNOMEDCT_2010_1_31:266238009 SNOMEDCT_2010_1_31:91025000 UMLS_CUI:C0155689 Idiopathic myocarditis Idiopathic myocarditis (disorder) Idiopathic myocarditis NOS (disorder) Isolated (Fiedler's) myocarditis Isolated (Fiedler's) myocarditis (disorder) disease_ontology DOID:10778 fiedler's myocarditis DOID:10778 ICD9CM:422.92 SNOMEDCT_2010_1_31:194959002 SNOMEDCT_2010_1_31:64043005 UMLS_CUI:C0155690 Septic myocarditis NOS (disorder) Septic myocarditis, NOS disease_ontology DOID:10779 septic myocarditis DOID:10779 ICD9CM:401.0 NCI:C34802 SNOMEDCT_2010_1_31:1218009 SNOMEDCT_2010_1_31:78975002 UMLS_CUI:C0024588 Accelerated essential hypertension malignant Essential hypertension malignant essential hypertension (disorder) disease_ontology DOID:10823 malignant essential hypertension DOID:10823 MSH:D006974 NCI:C3118 SNOMEDCT_2010_1_31:155301003 SNOMEDCT_2010_1_31:286951002 SNOMEDCT_2010_1_31:70272006 UMLS_CUI:C0020540 malignant hypertension malignant hypertension (disorder) disease_ontology DOID:10824 malignant hypertension DOID:10824 ICD9CM:401 ICD9CM:401.9 NCI:C3478 OMIM:145500 SNOMEDCT_2010_1_31:155296003 SNOMEDCT_2010_1_31:194757006 SNOMEDCT_2010_1_31:194760004 SNOMEDCT_2010_1_31:266228004 SNOMEDCT_2010_1_31:59621000 UMLS_CUI:C0085580 Essential hypertension Essential hypertension (disorder) Essential hypertension NOS Essential hypertension NOS (disorder) Unspecified essential hypertension idiopathic hypertension primary hypertension disease_ontology DOID:10825 OMIM mapping confirmed by DO. [SN]. essential hypertension DOID:10825 ICD9CM:451.81 SNOMEDCT_2010_1_31:195429006 UMLS_CUI:C0155772 Phlebitis and thrombophlebitis of the iliac vein NOS (disorder) disease_ontology DOID:10880 iliac vein thrombophlebitis DOID:10880 ICD9CM:401.1 NCI:C3656 SNOMEDCT_2010_1_31:1201005 SNOMEDCT_2010_1_31:194758001 UMLS_CUI:C0155583 benign Essential hypertension benign essential hypertension (disorder) disease_ontology DOID:10913 benign essential hypertension DOID:10913 MSH:D002532 NCI:C34458 SNOMEDCT_2010_1_31:128609009 SNOMEDCT_2010_1_31:42994005 UMLS_CUI:C0007766 intracranial aneurysm intracranial aneurysm (disorder) intracranial aneurysm, NOS disease_ontology DOID:10941 intracranial aneurysm intracranial aneurysm disease DOID:10941 MSH:D020144 UMLS_CUI:C0751739 disease_ontology DOID:10991 basal ganglia cerebrovascular disease DOID:10991 ICD9CM:405 ICD9CM:405.9 NCI:C3657 SNOMEDCT_2010_1_31:155300002 SNOMEDCT_2010_1_31:194789002 SNOMEDCT_2010_1_31:194792003 SNOMEDCT_2010_1_31:31992008 UMLS_CUI:C0155616 disease_ontology DOID:11130 secondary hypertension DOID:11130 ICD9CM:441.6 SNOMEDCT_2010_1_31:195265003 UMLS_CUI:C1305122 Thoracoabdominal aortic aneurysm, ruptured (disorder) disease_ontology DOID:11138 ruptured thoracoabdominal aortic aneurysm ruptured thoracoabdominal aortic aneurysm disease DOID:11138 DOID:111 DOID:13536 DOID:14031 ICD9CM:456.0 NCI:C78282 SNOMEDCT_2010_1_31:17709002 SNOMEDCT_2010_1_31:195474004 SNOMEDCT_2010_1_31:195475003 SNOMEDCT_2010_1_31:195479009 SNOMEDCT_2010_1_31:195643006 SNOMEDCT_2010_1_31:236067006 UMLS_CUI:C0155789 UMLS_CUI:C0155791 UMLS_CUI:C0155792 Bleeding esophageal varices Bleeding esophageal varices (disorder) Bleeding oesophageal varices esophageal varices esophageal varices in disease classified elsewhere, with bleeding esophageal varices with bleeding esophageal varices with bleeding in disease EC (disorder) esophageal varices without bleeding esophageal varices without bleeding (disorder) esophageal varices without mention of bleeding disease_ontology DOID:112 esophageal varix DOID:112 ICD9CM:433.2 UMLS_CUI:C0155724 Occlusion and stenosis of vertebral artery disease_ontology DOID:11299 vertebral artery occlusion DOID:11299 DOID label changed for homogeneization reasons. ICD9CM:426.12 NCI:C62018 SNOMEDCT_2010_1_31:28189009 UMLS_CUI:C0155700 Mobitz (type) II atrioventricular block Mobitz II atrioventricular block Mobitz type II atrioventricular block Mobitz type II atrioventricular block (disorder) disease_ontology DOID:11312 Mobitz II second degree atrioventricular block (disease) DOID:11312 ICD9CM:437.4 SNOMEDCT_2010_1_31:28366008 UMLS_CUI:C0007773 Cerebral arteritis (disorder) disease_ontology DOID:11390 cerebral arteritis DOID:11390 A disease affecting the heart. A cardiovascular system disease that involves the heart or blood vessels (arteries and veins). ICD9CM:429.9 MSH:D006331 NCI:C3079 SNOMEDCT_2010_1_31:155263000 SNOMEDCT_2010_1_31:194707003 SNOMEDCT_2010_1_31:195152001 SNOMEDCT_2010_1_31:266275004 SNOMEDCT_2010_1_31:266311004 SNOMEDCT_2010_1_31:56265001 UMLS_CUI:C0018799 disease_ontology DOID:114 heart disease DOID:114 ICD9CM:348.2 MSH:D011559 NCI:C85035 OMIM:243200 SNOMEDCT_2010_1_31:155052007 SNOMEDCT_2010_1_31:267701004 SNOMEDCT_2010_1_31:68267002 UMLS_CUI:C0033845 Pseudotumor cerebri benign intracran. hypt. benign intracranial hypertension benign intracranial hypertension (disorder) idiopathic intracranial hypertension disease_ontology DOID:11459 OMIM mapping confirmed by DO. [SN]. pseudotumor cerebri DOID:11459 ICD9CM:423.2 MSH:D010494 NCI:C78246 SNOMEDCT_2010_1_31:155340008 SNOMEDCT_2010_1_31:194969008 SNOMEDCT_2010_1_31:85598007 UMLS_CUI:C0031048 Constrictive pericarditis Constrictive pericarditis (disorder) Constrictive pericarditis NOS (disorder) disease_ontology DOID:11481 constrictive pericarditis DOID:11481 A pericardial effusion that results from blood in the pericardial sac. ICD9CM:423.0 MSH:D010490 SNOMEDCT_2010_1_31:155339006 SNOMEDCT_2010_1_31:23412002 UMLS_CUI:C0019064 Haemopericardium disease_ontology DOID:11482 hemopericardium DOID:11482 A disease caused by the presence of fluid in the pericardial cavity (due to pericardial effusion), affecting negatively the heart's pumping function. In CVDO, cardiac tamponade is defined as *being caused* by a pericardial effusion, rather than as *being* a pericardial effusion. A pericardial effusion in which fluid accumulates in the pericardium (the sac in which the heart is enclosed) and the pericardial spaces fills up faster than the pericardial sac can stretch. ICD9CM:423.3 MSH:D002305 NCI:C50481 SNOMEDCT_2010_1_31:155341007 SNOMEDCT_2010_1_31:194975004 SNOMEDCT_2010_1_31:266295005 SNOMEDCT_2010_1_31:35304003 UMLS_CUI:C0007177 Rose's tamponade pericardial tamponade disease_ontology DOID:115 cardiac tamponade DOID:115 A disease in which an abnormal structure in a mitral valve prevents it to close propertly during systole, occasioning a retrograd blood flow through the valve. DOID:11737 MSH:D008944 NCI:C50852 NCI:C50888 SNOMEDCT_2010_1_31:194736003 SNOMEDCT_2010_1_31:194977007 SNOMEDCT_2010_1_31:48724000 SNOMEDCT_2010_1_31:59464004 UMLS_CUI:C0026266 UMLS_CUI:C0264774 Mitral valve incompetence mitral regurgitation disease_ontology DOID:11502 mitral valve insufficiency DOID:11502 ICD9CM:394 SNOMEDCT_2010_1_31:155276006 SNOMEDCT_2010_1_31:194724009 SNOMEDCT_2010_1_31:250998008 SNOMEDCT_2010_1_31:266278002 SNOMEDCT_2010_1_31:286947004 SNOMEDCT_2010_1_31:83898004 UMLS_CUI:C0264765 Mitral RH valve dis. Mitral valve disease Rheumatic disease of mitral valve (disorder) Rheumatic mitral valve changes chronic rheumatic mitral valve (disorder) disease of mitral valve disease_ontology DOID:11505 rheumatic disease of mitral valve DOID:11505 MSH:D006502 SNOMEDCT_2010_1_31:195436007 SNOMEDCT_2010_1_31:38739001 UMLS_CUI:C0019154 Budd - Chiari syndrome (hepatic vein thrombosis) Budd-Chiari syndrome Budd-Chiari syndrome (disorder) hepatic vein thrombosis hepatic vein thrombosis (disorder) disease_ontology DOID:11512 hepatic vein thrombosis DOID:11512 A heart disease that is caused by high blood presure. ICD9CM:402 ICD9CM:402.9 SNOMEDCT_2010_1_31:155297007 SNOMEDCT_2010_1_31:194769003 SNOMEDCT_2010_1_31:194772005 SNOMEDCT_2010_1_31:64715009 UMLS_CUI:C0152105 disease_ontology DOID:11516 hypertensive heart disease DOID:11516 ICD9CM:403.1 ICD9CM:403.10 SNOMEDCT_2010_1_31:193003 UMLS_CUI:C0155596 benign hypertensive renal disease (disorder) hypertensive renal disease, benign hypertensive renal disease, benign, without mention of renal failure disease_ontology DOID:11520 benign hypertensive renal disease DOID:11520 A disease characterized by an inflammation of a retinal artery. ICD9CM:362.18 MSH:D031300 SNOMEDCT_2010_1_31:193367006 SNOMEDCT_2010_1_31:77628002 UMLS_CUI:C0152026 Retinal vasculitis Retinal vasculitis (disorder) Retinal vasculitis NOS (disorder) disease_ontology DOID:11563 retinal vasculitis DOID:11563 ICD9CM:587 MSH:D009400 SNOMEDCT_2010_1_31:194773000 SNOMEDCT_2010_1_31:197658002 SNOMEDCT_2010_1_31:197662008 SNOMEDCT_2010_1_31:32916005 UMLS_CUI:C0027719 Nephrosclerosis (disorder) nephrosclerosis renal sclerosis renal sclerosis NOS (disorder) renal sclerosis unspecified (disorder) renal sclerosis, unspecified disease_ontology DOID:11664 nephrosclerosis DOID:11664 A thrombosis that occurs in a portal vein. ICD9CM:452 NCI:C78565 SNOMEDCT_2010_1_31:155455003 SNOMEDCT_2010_1_31:17920008 UMLS_CUI:C0155773 disease_ontology DOID:11695 portal vein thrombosis DOID:11695 MSH:D003925 NCI:C35610 UMLS_CUI:C0011875 Diabetic vascular disorder diabetic angiopathy disease_ontology DOID:11713 diabetic angiopathy DOID:11713 A heart disease that is characterized by an abnormal accumulation of fluid in the pericardial cavity. MSH:D010490 NCI:C3319 SNOMEDCT_2010_1_31:373945007 SNOMEDCT_2010_1_31:70370001 UMLS_CUI:C0031039 disease_ontology DOID:118 pericardial effusion DOID:118 A coronary heart disease with coronary artery smooth muscle constriction. MSH:D003329 NCI:C34515 SNOMEDCT_2010_1_31:23687008 UMLS_CUI:C0010073 Coronary Vasospasm Coronary artery spasm (disorder) disease_ontology DOID:11840 coronary artery vasospasm DOID:11840 ICD9CM:746.85 SNOMEDCT_2010_1_31:204373000 SNOMEDCT_2010_1_31:204380003 SNOMEDCT_2010_1_31:28574005 SNOMEDCT_2010_1_31:361215006 UMLS_CUI:C0158623 Congenital anomaly of coronary artery (disorder) Coronary artery abnormality (disorder) Coronary artery abnormality [Ambiguous] Coronary artery anomaly NOS (disorder) Coronary artery anomaly, congenital disease_ontology DOID:11843 coronary artery anomaly DOID:11843 A thrombosis occuring in a coronary artery. MSH:D003328 SNOMEDCT_2010_1_31:155304006 SNOMEDCT_2010_1_31:194796000 SNOMEDCT_2010_1_31:266288001 SNOMEDCT_2010_1_31:398274000 SNOMEDCT_2010_1_31:66514008 UMLS_CUI:C0010072 Coronary artery thrombosis (disorder) Coronary thrombosis coronary thrombosis disease_ontology DOID:11847 coronary thrombosis DOID:11847 "A heart disease with increased ventricular wall thickness or mass in the absence of loading conditions (hypertension, valve disease) sufficient to cause the observed abnormality." (Elliott et al., 2008, European Heart Journal, 29, 270-276) ICD9CM:425.1 MSH:D002312 NCI:C34449 OMIM:192600 SNOMEDCT_2010_1_31:15471000 SNOMEDCT_2010_1_31:155351008 SNOMEDCT_2010_1_31:233873004 SNOMEDCT_2010_1_31:266301006 SNOMEDCT_2010_1_31:389998005 SNOMEDCT_2010_1_31:389999002 SNOMEDCT_2010_1_31:45227007 UMLS_CUI:C0007194 Cardiomyopathy, hypertrophic hyper. obst. cardiomyopathy hypertrophic cardiomyopathy hypertrophic cardiomyopathy (disorder) hypertrophic myocardiopathy hypertrophic obstructive cardiomyopathy hypertrophic obstructive cardiomyopathy (disorder) primary hypertrophic cardiomyopathy (disorder) [Ambiguous] disease_ontology DOID:11984 OMIM mapping confirmed by DO. [LS]. hypertrophic cardiomyopathy DOID:11984 ICD9CM:377.41 MSH:D018917 SNOMEDCT_2010_1_31:14357004 UMLS_CUI:C0155305 Ischemic optic neuropathy Ischemic optic neuropathy (disorder) disease_ontology DOID:12010 ischemic optic neuropathy DOID:12010 ICD9CM:395.0 SNOMEDCT_2010_1_31:155282009 SNOMEDCT_2010_1_31:72011007 UMLS_CUI:C0155567 Rheumatic aortic stenosis Rheumatic aortic stenosis (disorder) Rheumatic aortic valve stenosis disease_ontology DOID:12034 rheumatic aortic valve stenosis DOID:12034 ICD9CM:451.11 SNOMEDCT_2010_1_31:1748006 SNOMEDCT_2010_1_31:195410000 UMLS_CUI:C0265066 Phlebitis and thrombophlebitis of femoral vein (deep) (superficial) Thrombophlebitis of deep femoral vein (disorder) Thrombophlebitis of the femoral vein (disorder) disease_ontology DOID:12282 femoral vein thrombophlebitis DOID:12282 A chronic pulmonary heart disease caused by a kyphoscoliosis. ICD9CM:416.1 SNOMEDCT_2010_1_31:194886003 SNOMEDCT_2010_1_31:45650007 UMLS_CUI:C0152102 Kyphoscoliotic heart disease (disorder) disease_ontology DOID:12325 kyphoscoliotic heart disease DOID:12325 A cor pulmonale that has a chronic disease course during which the right ventricle becomes hypertrophied. ICD9CM:416.8 SNOMEDCT_2010_1_31:194887007 SNOMEDCT_2010_1_31:194889005 UMLS_CUI:C0155673 disease_ontology DOID:12326 chronic pulmonary heart disease DOID:12326 ICD9CM:456.4 MSH:D014646 SNOMEDCT_2010_1_31:155480003 SNOMEDCT_2010_1_31:195480007 SNOMEDCT_2010_1_31:46871008 SNOMEDCT_2010_1_31:51070004 UMLS_CUI:C0042341 Scrotal varices Scrotal varices (disorder) Varicocele (disorder) Varicocele [Ambiguous] varicocele disease_ontology DOID:12337 varicocele DOID:12337 ICD9CM:448 SNOMEDCT_2010_1_31:155446001 SNOMEDCT_2010_1_31:155449008 SNOMEDCT_2010_1_31:195250004 SNOMEDCT_2010_1_31:195380006 SNOMEDCT_2010_1_31:195390003 SNOMEDCT_2010_1_31:266324004 SNOMEDCT_2010_1_31:57223003 SNOMEDCT_2010_1_31:58729003 UMLS_CUI:C0155765 disease of capillaries disease_ontology DOID:1271 capillary disease DOID:1271 MSH:D013684 NCI:C28194 SNOMEDCT_2010_1_31:112641009 SNOMEDCT_2010_1_31:155449008 SNOMEDCT_2010_1_31:247479008 SNOMEDCT_2010_1_31:266324004 SNOMEDCT_2010_1_31:276328002 UMLS_CUI:C0039446 telangiectasia disease_ontology DOID:1272 telangiectasis DOID:1272 ICD9CM:437.0 MSH:D002537 NCI:C34459 SNOMEDCT_2010_1_31:195220007 SNOMEDCT_2010_1_31:266258005 SNOMEDCT_2010_1_31:55382008 UMLS_CUI:C0007775 Cerebral atherosclerosis Cerebral atherosclerosis (disorder) disease_ontology DOID:12720 cerebral atherosclerosis DOID:12720 A disease affecting the cardiovascular system. A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. DOID:73 ICD9CM:429.2 MSH:D002318 NCI:C2931 SNOMEDCT_2010_1_31:105980002 SNOMEDCT_2010_1_31:155263000 SNOMEDCT_2010_1_31:194707003 SNOMEDCT_2010_1_31:195139006 SNOMEDCT_2010_1_31:195594006 SNOMEDCT_2010_1_31:266275004 SNOMEDCT_2010_1_31:266336005 SNOMEDCT_2010_1_31:49601007 UMLS_CUI:C0007222 cardiovascular system disease disease of subdivision of hemolymphoid system disease_ontology DOID:1287 cardiovascular system disease DOID:1287 ICD9CM:443.1 MSH:D013919 NCI:C35070 OMIM:211480 SNOMEDCT_2010_1_31:155432001 SNOMEDCT_2010_1_31:195298008 SNOMEDCT_2010_1_31:195299000 SNOMEDCT_2010_1_31:195300008 SNOMEDCT_2010_1_31:52403007 UMLS_CUI:C0040021 Buerger's disease Presenile gangrene Presenile gangrene (disorder) Thromboangiitis obliterans Thromboangiitis obliterans (disorder) Thromboangiitis obliterans NOS (disorder) Thromboangiitis obliterans [Buerger's disease] disease_ontology DOID:12918 OMIM mapping confirmed by DO. [LS]. thromboangiitis obliterans DOID:12918 A heart disease in which the endocardium thickens by increase in the amount of supporting connective tissue and elastic fibers. It is usually associated with children two years old and younger. Its etiological cause is unknown. ICD9CM:425.3 MSH:D004695 OMIM:226000 OMIM:305300 SNOMEDCT_2010_1_31:65457005 UMLS_CUI:C0014117 Elastomyofibrosis Endocardial fibroelastosis Endocardial fibroelastosis (disorder) endocardial fibroelastosis disease_ontology DOID:12929 OMIM mapping confirmed by DO. [SN]. endocardial fibroelastosis DOID:12929 A cardiomyopathy characterized by left ventricular dilatation and left ventricular systolic dysfunction in the absence of abnormal loading conditions (hypertension, valve disease) or coronary heart disease sufficient to cause global systolic impairment. (adapted from Elliott et al., 2008, European Heart Journal, 29, 270-276) An intrinsic cardiomyopathy that results in damage to the myocardium causing the heart to pump blood inefficiently. MSH:D002311 NCI:C84673 OMIM:115200 OMIM:300069 OMIM:302045 OMIM:601154 OMIM:601493 OMIM:601494 OMIM:604145 OMIM:604765 OMIM:605362 OMIM:606685 OMIM:607482 OMIM:607487 OMIM:608569 OMIM:609909 OMIM:611407 OMIM:611878 OMIM:611879 OMIM:611880 OMIM:612158 OMIM:612877 OMIM:613122 OMIM:613172 OMIM:613252 OMIM:613286 OMIM:613424 OMIM:613426 OMIM:613642 OMIM:613697 SNOMEDCT_2010_1_31:195018001 SNOMEDCT_2010_1_31:195021004 SNOMEDCT_2010_1_31:389995008 SNOMEDCT_2010_1_31:399020009 SNOMEDCT_2010_1_31:74368002 UMLS_CUI:C0007193 Cardiomyopathy, congestive primary dilated cardiomyopathy (disorder) disease_ontology Congestive cardiomyopathy DOID:12930 OMIM mapping confirmed by DO. [LS]. dilated cardiomyopathy DOID:12930 A restrictive cardiomyopathy which results in fibrous lesions of right and left ventricle. It occurs typically in tropical and subtropical Africa. ICD9CM:425.0 MSH:D004719 NCI:C34585 SNOMEDCT_2010_1_31:111507009 SNOMEDCT_2010_1_31:123264005 SNOMEDCT_2010_1_31:155351008 SNOMEDCT_2010_1_31:266301006 SNOMEDCT_2010_1_31:30293000 SNOMEDCT_2010_1_31:398716006 UMLS_CUI:C0553980 (Becker's disease) or (obscure African cardiomyopathy) African endomyocardial fibrosis Becker's disease Endomyocardial sclerosis Obscure African cardiomyopathy (disorder) disease_ontology DOID:12932 endomyocardial fibrosis DOID:12932 A dilated cardiomyopathy resulting from alcohol intoxication. ICD9CM:425.5 MSH:D002310 NCI:C53653 SNOMEDCT_2010_1_31:155352001 SNOMEDCT_2010_1_31:83521008 UMLS_CUI:C0007192 Alcohol-induced heart muscle disease Alcoholic cardiomyopathy Dilated cardiomyopathy secondary to alcohol (disorder) disease_ontology DOID:12935 alcoholic cardiomyopathy DOID:12935 MSH:D016893 SNOMEDCT_2010_1_31:195181000 SNOMEDCT_2010_1_31:64586002 UMLS_CUI:C0007282 Carotid artery stenosis (disorder) Stenosis, carotid artery disease_ontology DOID:13001 carotid stenosis DOID:13001 ICD9CM:435.3 MSH:D014715 SNOMEDCT_2010_1_31:155404005 SNOMEDCT_2010_1_31:195196001 SNOMEDCT_2010_1_31:195199008 SNOMEDCT_2010_1_31:266314007 SNOMEDCT_2010_1_31:394517009 SNOMEDCT_2010_1_31:64009001 UMLS_CUI:C0042568 Vertebro-basilar insufficiency Vertebrobasilar arterial insufficiency Vertebrobasilar artery syndrome Vertebrobasilar artery syndrome (disorder) Vertebrobasilar insufficiency disease_ontology DOID:13003 vertebrobasilar insufficiency DOID:13003 ICD9CM:747.83 MSH:D010547 NCI:C85006 OMIM:265380 SNOMEDCT_2010_1_31:204507004 SNOMEDCT_2010_1_31:206597007 SNOMEDCT_2010_1_31:233815004 SNOMEDCT_2010_1_31:35604006 UMLS_CUI:C0031190 Fetal circulation Persistent fetal circulation Persistent fetal circulation (disorder) Persistent fetal circulation syndrome (disorder) Persistent pulmonary hypertension of the newborn (disorder) congenital alveolar capillary dysplasia with misalignment of pulmonary veins persistent pulmonary hypertension of the newborn disease_ontology DOID:13042 OMIM mapping confirmed by DO. [SN]. persistent fetal circulation syndrome DOID:13042 MSH:D020765 UMLS_CUI:C0752138 disease_ontology DOID:13089 intracranial arterial disease DOID:13089 ICD9CM:362.32 MSH:D015356 NCI:C34436 SNOMEDCT_2010_1_31:50821009 UMLS_CUI:C0006123 Arterial retinal branch occlusion (disorder) Retinal Arterial Branch Occlusion Retinal arterial branch occlusion disease_ontology DOID:13094 branch retinal artery occlusion DOID:13094 MSH:D014715 SNOMEDCT_2010_1_31:195198000 SNOMEDCT_2010_1_31:34781003 UMLS_CUI:C0042560 Vertebral artery syndrome Vertebral artery syndrome (disorder) disease_ontology DOID:13095 vertebral artery insufficiency DOID:13095 MSH:D018860 OMIM:182410 SNOMEDCT_2010_1_31:238776001 UMLS_CUI:C0282492 Idiopathic livedo reticularis with systemic involvement (disorder) disease_ontology DOID:13096 Sneddon syndrome DOID:13096 MSH:D002537 UMLS_CUI:C0007771 disease_ontology DOID:13097 intracranial arteriosclerosis DOID:13097 ICD9CM:362.31 MSH:D015356 NCI:C34456 SNOMEDCT_2010_1_31:38742007 UMLS_CUI:C0007688 central retinal artery occlusion central retinal artery occlusion (disorder) disease_ontology DOID:13098 central retinal artery occlusion DOID:13098 ICD9CM:437.5 MSH:D009072 NCI:C84895 OMIM:252350 SNOMEDCT_2010_1_31:69116000 SNOMEDCT_2010_1_31:89142007 UMLS_CUI:C0026654 Moyamoya disease Moyamoya disease (disorder) progressive intracranial arterial occlusion (disorder) disease_ontology DOID:13099 OMIM mapping confirmed by DO. [SN]. Moyamoya disease DOID:13099 MSH:D020301 UMLS_CUI:C0751895 disease_ontology DOID:13100 intracranial vasospasm DOID:13100 DOID:13130 DOID:13131 DOID:13132 ICD9CM:642.50 UMLS_CUI:C0156669 Severe pre-eclampsia, with delivery antepartum severe pre-eclampsia postpartum severe pre-eclampsia disease_ontology DOID:13129 severe pre-eclampsia DOID:13129 MSH:D017359 NCI:C84750 SNOMEDCT_2010_1_31:199010001 SNOMEDCT_2010_1_31:95605009 UMLS_CUI:C0162739 HELLP syndrome (disorder) syndrome of haemolysis, elevated liver enzymes and low platelet disease_ontology DOID:13133 HELLP syndrome DOID:13133 ICD9CM:405.1 NCI:C3658 SNOMEDCT_2010_1_31:194785008 SNOMEDCT_2010_1_31:194787000 SNOMEDCT_2010_1_31:44111003 UMLS_CUI:C0155620 disease_ontology DOID:13143 benign secondary hypertension DOID:13143 ICD9CM:405.11 UMLS_CUI:C0155621 disease_ontology DOID:13145 benign renovascular hypertension DOID:13145 ICD9CM:426.51 SNOMEDCT_2010_1_31:46319007 UMLS_CUI:C0155704 Right bundle branch block with left posterior fascicular block (disorder) disease_ontology DOID:13209 right bundle branch block (disease) DOID:13209 An autoimmune disease of cardiovascular system that causes chronic inflammation in blood vessels throughout the body leading to ulcerations on the mouth and sometimes the genitals, notorious for causing hypopyon uveitis. ICD9CM:136.1 MSH:D001528 NCI:C34416 OMIM:109650 SNOMEDCT_2010_1_31:154424000 SNOMEDCT_2010_1_31:310701003 SNOMEDCT_2010_1_31:41225007 UMLS_CUI:C0004943 Adamantiades-Behcet disease Behcet syndrome Behet's syndrome (disorder) triple symptom complex disease_ontology Behcet's syndrome DOID:13241 OMIM mapping confirmed by DO. [SN]. Behcet's disease DOID:13241 ICD9CM:446.5 MSH:D013700 NCI:C35065 OMIM:187360 SNOMEDCT_2010_1_31:155442004 SNOMEDCT_2010_1_31:195354005 SNOMEDCT_2010_1_31:195355006 SNOMEDCT_2010_1_31:195356007 SNOMEDCT_2010_1_31:195357003 SNOMEDCT_2010_1_31:400130008 SNOMEDCT_2010_1_31:414341000 SNOMEDCT_2010_1_31:87511001 UMLS_CUI:C0039483 Giant cell Arteritis Giant cell arteritis Giant cell arteritis (disorder) Giant cell arteritis NOS (disorder) Horton's disease Temporal arteritis (disorder) giant cell arteritis disease_ontology DOID:13375 OMIM mapping confirmed by DO. [LS]. temporal arteritis DOID:13375 ICD9CM:446.1 MSH:D009080 NCI:C34825 OMIM:611775 SNOMEDCT_2010_1_31:155444003 SNOMEDCT_2010_1_31:195348009 SNOMEDCT_2010_1_31:195349001 SNOMEDCT_2010_1_31:75053002 UMLS_CUI:C0026691 Kawasaki disease Kawasaki's disease MLNS acute febrile MCLS acute febrile mucocutaneous lymph node syndrome (disorder) acute febrile mucocutaneous lymph node syndrome NOS (disorder) acute febrile mucocutaneous lymph node syndrome [MCLS] mucocutaneous lymph node syndrome disease_ontology DOID:13378 OMIM mapping confirmed by DO. [SN]. Kawasaki disease DOID:13378 ICD9CM:433.0 SNOMEDCT_2010_1_31:155396001 SNOMEDCT_2010_1_31:195180004 SNOMEDCT_2010_1_31:78658006 UMLS_CUI:C0265098 disease_ontology DOID:13446 basilar artery occlusion DOID:13446 DOID:13592 MSH:D004461 NCI:C87167 SNOMEDCT_2010_1_31:156111007 SNOMEDCT_2010_1_31:15938005 SNOMEDCT_2010_1_31:198988006 SNOMEDCT_2010_1_31:198989003 SNOMEDCT_2010_1_31:198996001 UMLS_CUI:C0013537 Eclampsia (disorder) Eclampsia NOS (disorder) Eclampsia in puerperium (disorder) Eclampsia unspecified (disorder) Eclampsia, postpartum Postpartum eclampsia eclampsia disease_ontology DOID:13593 eclampsia DOID:13593 UMLS_CUI:C0155618 disease_ontology DOID:13730 malignant renovascular hypertension DOID:13730 ICD9CM:405.0 SNOMEDCT_2010_1_31:194784007 SNOMEDCT_2010_1_31:49863005 SNOMEDCT_2010_1_31:89242004 UMLS_CUI:C0155617 disease_ontology DOID:13731 malignant secondary hypertension DOID:13731 ICD9CM:573.4 SNOMEDCT_2010_1_31:17890003 UMLS_CUI:C0151731 hepatic infarction hepatic infarction (disorder) disease_ontology DOID:13738 infarct of liver DOID:13738 ICD9CM:573.0 SNOMEDCT_2010_1_31:34736002 UMLS_CUI:C0156195 chronic passive congestion of liver chronic passive congestion of liver (disorder) disease_ontology DOID:13739 nutmeg liver DOID:13739 ICD9CM:397.0 SNOMEDCT_2010_1_31:155289000 SNOMEDCT_2010_1_31:194745002 SNOMEDCT_2010_1_31:266282000 SNOMEDCT_2010_1_31:49699002 UMLS_CUI:C0264776 RH. tricuspid valve disease Rheumatic disease of tricuspid valve (disorder) Rheumatic tricuspid valve disease NOS (disorder) Tricuspid disease disease of tricuspid valve disease_ontology DOID:13834 rheumatic tricuspid valve disease DOID:13834 A heart conduction disease characterized by inappropriate sinus rates (e.g. sinus bradycardia or sinus pause). MSH:D012804 NCI:C62244 SNOMEDCT_2010_1_31:155373001 SNOMEDCT_2010_1_31:266307005 SNOMEDCT_2010_1_31:36083008 UMLS_CUI:C0037052 disease_ontology DOID:13884 sick sinus syndrome DOID:13884 ICD9CM:441.2 MSH:D017545 NCI:C27001 OMIM:132900 OMIM:611788 SNOMEDCT_2010_1_31:155421001 SNOMEDCT_2010_1_31:195259003 SNOMEDCT_2010_1_31:433068007 SNOMEDCT_2010_1_31:74883004 UMLS_CUI:C0162872 Thoracic Aortic Aneurysm Thoracic aortic aneurysm Thoracic aortic aneurysm without mention of rupture Thoracic aortic aneurysm without mention of rupture (disorder) Thoracic aortic aneurysm without rupture disease_ontology DOID:14004 OMIM mapping confirmed by DO. [SN]. thoracic aortic aneurysm thoracic aortic aneurysm disease DOID:14004 ICD9CM:442.83 SNOMEDCT_2010_1_31:70405009 UMLS_CUI:C0155747 disease_ontology DOID:14006 splenic artery aneurysm splenic artery aneurysm disease DOID:14006 ICD9CM:747.22 SNOMEDCT_2010_1_31:204431007 SNOMEDCT_2010_1_31:204438001 UMLS_CUI:C0345010 Atresia and stenosis of aorta (disorder) Atresia or stenosis of aorta NOS (disorder) Congenital atresia and stenosis of aorta disease_ontology DOID:14037 aorta atresia DOID:14037 ICD9CM:440.1 SNOMEDCT_2010_1_31:155416004 SNOMEDCT_2010_1_31:45281005 UMLS_CUI:C0155734 Atherosclerosis of renal artery Atherosclerosis of renal artery (disorder) renal atherosclerosis disease_ontology DOID:14092 renal artery atheroma DOID:14092 MSH:D018438 UMLS_CUI:C0242645 disease_ontology DOID:14121 blue toe syndrome DOID:14121 A congestive heart failure caused by a rheumatic fever. ICD9CM:398.91 SNOMEDCT_2010_1_31:82523003 UMLS_CUI:C0155582 Congestive rheumatic heart failure (disorder) Rheumatic heart failure Rheumatic heart failure (congestive) disease_ontology DOID:14172 rheumatic congestive heart failure DOID:14172 A disease in which an abnormal structure in a pulmonary valve prevents it to close propertly during diastole, occasioning a retrograd blood flow through the valve. A pulmonary valve disease that occurs when the pulmonary valve is not strong enough to prevent backflow into the right ventricle. If it is secondary to pulmonary hypertension it is referred to as a Graham Steell murmur. DOID:11210 ICD9CM:518.5 UMLS_CUI:C0034076 Pulmonic insufficiency NOS Pulmonic valve regurgitation (disorder) pulmonary incompetence pulmonary incompetence, non-rheumatic (disorder) pulmonary insufficiency following trauma and surgery pulmonary regurg. pulmonary regurgitation disease_ontology DOID:14265 pulmonary valve insufficiency DOID:14265 ICD9CM:453.1 SNOMEDCT_2010_1_31:155456002 SNOMEDCT_2010_1_31:155491005 SNOMEDCT_2010_1_31:31268005 UMLS_CUI:C0152250 Thrombophlebitis migrans (disorder) disease_ontology DOID:14392 thrombophlebitis migrans DOID:14392 MSH:D019559 NCI:C62578 SNOMEDCT_2010_1_31:87730004 UMLS_CUI:C0343084 Capillary leak syndrome (disorder) disease_ontology DOID:14400 capillary leak syndrome DOID:14400 ICD9CM:708.5 SNOMEDCT_2010_1_31:73098005 UMLS_CUI:C0152230 Cholinergic urticaria (disorder) disease_ontology DOID:14443 cholinergic urticaria DOID:14443 ICD9CM:362.33 NCI:C35192 SNOMEDCT_2010_1_31:193376004 SNOMEDCT_2010_1_31:776009 UMLS_CUI:C0154839 Partial Retinal Arterial Occlusion Partial arterial retinal occlusion (disorder) Partial retinal arterial occlusion Retinal partial arterial occlusion NOS (disorder) disease_ontology DOID:14522 partial arterial retinal occlusion DOID:14522 ICD9CM:416.0 MSH:C536282 OMIM:178600 OMIM:265400 SNOMEDCT_2010_1_31:155328008 SNOMEDCT_2010_1_31:26174007 SNOMEDCT_2010_1_31:266293003 UMLS_CUI:C0152171 primary pulmonary hypertension primary pulmonary hypertension (disorder) pulmonary hypertension (& [primary]) pulmonary hypertension, idiopathic disease_ontology DOID:14557 OMIM mapping confirmed by DO. [SN]. primary pulmonary hypertension DOID:14557 UMLS_CUI:C1135215 disease_ontology DOID:1460 atheroembolism of kidney DOID:1460 An embolism due to an embolus made of cholesterol. ICD9CM:445 MSH:D017700 SNOMEDCT_2010_1_31:10690002 UMLS_CUI:C0149649 disease_ontology DOID:1461 cholesterol embolism DOID:1461 MSH:D054179 NCI:C84758 OMIM:106100 OMIM:610618 SNOMEDCT_2010_1_31:82966003 UMLS_CUI:C0019243 HANE Hereditary angioedema Hereditary angioneurotic edema (disorder) disease_ontology DOID:14735 OMIM mapping confirmed by DO. [SN]. hereditary angioedema DOID:14735 ICD9CM:708.4 SNOMEDCT_2010_1_31:51247001 UMLS_CUI:C0157743 Vibratory urticaria (disorder) disease_ontology DOID:1554 vibratory urticaria DOID:1554 ICD9CM:708.8 MSH:D014581 SNOMEDCT_2010_1_31:201267004 SNOMEDCT_2010_1_31:201271001 SNOMEDCT_2010_1_31:267817001 UMLS_CUI:C0029839 disease_ontology DOID:1555 urticaria DOID:1555 MSH:D000799 SNOMEDCT_2010_1_31:157756002 SNOMEDCT_2010_1_31:269433002 SNOMEDCT_2010_1_31:400075008 SNOMEDCT_2010_1_31:41291007 SNOMEDCT_2010_1_31:82966003 UMLS_CUI:C0002994 Angioedema (disorder) Angioneurotic oedema Giant urticaria Giant urticaria (disorder) QUINCKE'S EDEMA Quincke's edema angioedema angioneurotic edema giant urticaria disease_ontology DOID:1558 angioedema DOID:1558 MSH:D006978 NCI:C85044 SNOMEDCT_2010_1_31:123799005 SNOMEDCT_2010_1_31:194790006 UMLS_CUI:C0020545 Renovascular hypertension (disorder) disease_ontology DOID:1591 renovascular hypertension DOID:1591 NCI:C40381 UMLS_CUI:C1511284 disease_ontology DOID:1637 breast angiomatosis DOID:1637 A disease in which some disorder of the aortic valve leads prevents it from opening properly during left ventricular systole, occasioning disturbance in the anterograd blood flow through the valve. Aortic valve stenosis is a aortic valve disease caused by the incomplete opening of the aortic valve. The aortic valve controls the direction of blood flow from the left ventricle to the aorta. When in good working order, the aortic valve does not impede the flow of blood between these two spaces. Under some circumstances, the aortic valve becomes narrower than normal, impeding the flow of blood. This is known as aortic valve stenosis, or aortic stenosis, often abbreviated AS. MSH:D001024 NCI:C50462 SNOMEDCT_2010_1_31:390722003 SNOMEDCT_2010_1_31:60573004 UMLS_CUI:C0003507 AS Aortic stenosis Aortic valve stenosis (disorder) aortic valve stenosis disease_ontology DOID:1712 aortic valve stenosis DOID:1712 ICD9CM:362.3 ICD9CM:362.30 NCI:C34980 SNOMEDCT_2010_1_31:155111000 SNOMEDCT_2010_1_31:193373007 SNOMEDCT_2010_1_31:193380009 SNOMEDCT_2010_1_31:267717005 SNOMEDCT_2010_1_31:73757007 UMLS_CUI:C0035326 Retinal vasc. occlusion Retinal vascular Occlusion Retinal vascular occlusion (disorder) Retinal vascular occlusion NOS (disorder) Retinal vascular occlusion, unspecified Unspecified retinal vascular occlusion (disorder) disease_ontology DOID:1729 retinal vascular occlusion DOID:1729 A disease in which some disorder of a mitral valve prevents it from opening properly during left ventricular diastole, occasioning disturbance in the anterograd blood flow through the valve. Mitral valve stenosis is a rheumatic disease of mitral valve characterized by the narrowing of the orifice of the mitral valve of the heart. Most cases of mitral stenosis are due to disease in the heart secondary to rheumatic fever and the consequent rheumatic heart disease. Less common causes of mitral stenosis are calcification of the mitral valve leaflets, and as a form of congenital heart disease. However, there are primary causes of mitral stenosis that emanate from a cleft mitral valve. Other causes include Bacterial endocarditis where the vegetations may favor increase risk of stenosis. MSH:D008946 NCI:C50654 SNOMEDCT_2010_1_31:155277002 SNOMEDCT_2010_1_31:194725005 SNOMEDCT_2010_1_31:79619009 UMLS_CUI:C0026269 Mitral stenosis Mitral stenosis NOS Mitral valve stenosis (disorder) mitral valve stenosis disease_ontology DOID:1754 mitral valve stenosis DOID:1754 A disease affecting a blood vessel. Reorganization of the vascular diseases, and writing of Aristotelian definitions, is still ongoing. A cardiovascular system disease that primarily affects the blood vessels. DOID:2869 DOID:45 MSH:D014652 NCI:C35117 SNOMEDCT_2010_1_31:27550009 UMLS_CUI:C0042373 UMLS_CUI:C0264951 arteriopathy internal elastic lamina disease_ontology Arterial disease DOID:178 vascular disease DOID:178 A disease characterized by an inflammation of the pericardium. A heart disease that is characterized by an inflammation of the pericardium and has_symptom chest pain. MSH:D010493 NCI:C34915 SNOMEDCT_2010_1_31:3238004 UMLS_CUI:C0031046 disease_ontology DOID:1787 pericarditis DOID:1787 A chronic pericarditis due to rheumatic fever. ICD9CM:393 SNOMEDCT_2010_1_31:155287003 SNOMEDCT_2010_1_31:194719006 SNOMEDCT_2010_1_31:194723003 SNOMEDCT_2010_1_31:78069008 UMLS_CUI:C0155561 chronic rheumatic pericarditis (disorder) chronic rheumatic pericarditis NOS (disorder) disease_ontology DOID:1869 chronic rheumatic pericarditis DOID:1869 A congenital disease involving the narrowing (stenosis) of aorta, hindering the opening of the aortic valve. Supravalvular aortic stenosis is not classified as an aortic valve stenosis: although the narrowing of the section of the aorta at the exit of the aortic valve implies some improper opening of the aortic valve, the aortic valve is (in general) healthy (there is no disorder nor pathological process inside it). However, this improper opening of the aortic valve is a pathological process that happens inside the heart; therefore, supravalvular aortic stenosis is classified as a heart disease. MSH:D021921 NCI:C85176 OMIM:185500 OMIM:194050 SNOMEDCT_2010_1_31:204436002 SNOMEDCT_2010_1_31:268185002 UMLS_CUI:C0003499 Supra-valvular aortic stenosis Supravalvar aortic stenosis (disorder) disease_ontology DOID:1929 supravalvular aortic stenosis DOID:1929 ICD9CM:440 MSH:D050197 NCI:C35768 SNOMEDCT_2010_1_31:155382007 SNOMEDCT_2010_1_31:155414001 SNOMEDCT_2010_1_31:194848007 SNOMEDCT_2010_1_31:195251000 SNOMEDCT_2010_1_31:266318005 SNOMEDCT_2010_1_31:38716007 UMLS_CUI:C0004153 disease_ontology DOID:1936 atherosclerosis DOID:1936 ICD9CM:435.0 MSH:D014715 NCI:C34413 SNOMEDCT_2010_1_31:195197005 SNOMEDCT_2010_1_31:64009001 UMLS_CUI:C0004812 Basilar artery syndrome Basilar artery syndrome (disorder) disease_ontology DOID:223 basilar artery insufficiency DOID:223 A brain ischemia that is part of a transient disease course. DOID:2315 MSH:D002546 NCI:C50781 SNOMEDCT_2010_1_31:155404005 SNOMEDCT_2010_1_31:195196001 SNOMEDCT_2010_1_31:195207009 SNOMEDCT_2010_1_31:266257000 SNOMEDCT_2010_1_31:266314007 SNOMEDCT_2010_1_31:313242003 SNOMEDCT_2010_1_31:38609002 UMLS_CUI:C0007787 UMLS_CUI:C0155728 TIA TIA - Transient ischaemic attack TRANSIENT ISCHEMIC ATTACK Transient cerebral ischaemia Transient cerebral ischaemia NOS Transient cerebral ischemia (disorder) [Ambiguous] Transient ischemic attacks (disorder) transient ischemic attack disease_ontology DOID:224 transient cerebral ischemia DOID:224 An ischemia of the brain. MSH:D002545 SNOMEDCT_2010_1_31:11890005 SNOMEDCT_2010_1_31:193049009 SNOMEDCT_2010_1_31:389100007 UMLS_CUI:C0007786 Ischaemic encephalopathy Ischemic encephalopathy (disorder) disease_ontology DOID:2316 brain ischemia DOID:2316 ICD9CM:440.9 NCI:C35767 SNOMEDCT_2010_1_31:367108003 SNOMEDCT_2010_1_31:39823006 UMLS_CUI:C0017327 Generalised atherosclerosis Generalized and unspecified atherosclerosis Generalized atherosclerosis (disorder) disease_ontology DOID:2347 generalized atherosclerosis DOID:2347 NCI:C34403 NCI:C35771 SNOMEDCT_2010_1_31:195121002 SNOMEDCT_2010_1_31:195251000 SNOMEDCT_2010_1_31:39468009 UMLS_CUI:C0003972 Arteriosclerotic Cardiovascular disease Arteriosclerotic cardiovascular disease Arteriosclerotic cardiovascular disease, NOS Atherosclerotic Cardiovascular disease Atherosclerotic cardiovascular disease Cardiovascular arteriosclerosis unspecified (disorder) disease_ontology DOID:2348 arteriosclerotic cardiovascular disease DOID:2348 MSH:D001161 NCI:C34398 SNOMEDCT_2010_1_31:107671003 SNOMEDCT_2010_1_31:155414001 SNOMEDCT_2010_1_31:155418003 SNOMEDCT_2010_1_31:195251000 SNOMEDCT_2010_1_31:195257001 SNOMEDCT_2010_1_31:266318005 SNOMEDCT_2010_1_31:28960008 SNOMEDCT_2010_1_31:72092001 UMLS_CUI:C0003850 Arteriosclerosis (morphologic abnormality) Arteriosclerosis NOS Arteriosclerotic vascular disease (disorder) Arteriosclerotic vascular disease NOS Arteriosclerotic vascular disease NOS (disorder) arteriosclerosis disease_ontology DOID:2349 arteriosclerosis DOID:2349 DOID:12820 DOID:2363 DOID:2720 ICD9CM:459.1 MSH:D011186 SNOMEDCT_2010_1_31:155460004 SNOMEDCT_2010_1_31:20427003 SNOMEDCT_2010_1_31:410013001 UMLS_CUI:C0032807 UMLS_CUI:C1135219 UMLS_CUI:C1135220 UMLS_CUI:C1135221 Postphlebetic syndrome with inflammation Postphlebetic syndrome with ulcer Postphlebetic syndrome with ulcer and inflammation disease_ontology DOID:2364 postphlebitic syndrome DOID:2364 ICD9CM:593.81 NCI:C35338 SNOMEDCT_2010_1_31:16934004 SNOMEDCT_2010_1_31:197814004 SNOMEDCT_2010_1_31:266559003 UMLS_CUI:C0268790 vascular disorder of kidney disease_ontology DOID:2388 renal vascular disease DOID:2388 A disposition that an aneurysm disorder will lead to pathological processes. DOID label 'aneurysm disease' changed for homogeneization purpose in CVDO. A vascular disease that is characterized by a localized, blood-filled balloon-like bulge in the wall of a blood vessel. ICD9CM:442.9 MSH:D000783 NCI:C26693 SNOMEDCT_2010_1_31:134342004 SNOMEDCT_2010_1_31:155425005 SNOMEDCT_2010_1_31:155428007 SNOMEDCT_2010_1_31:195292009 SNOMEDCT_2010_1_31:362727005 SNOMEDCT_2010_1_31:432119003 SNOMEDCT_2010_1_31:85659009 UMLS_CUI:C0002940 disease_ontology DOID:2403 aneurysm (disease) DOID:2403 NCI:C35170 SNOMEDCT_2010_1_31:57534004 UMLS_CUI:C0154833 retina circulation disorder disease_ontology DOID:2462 retinal vascular disease DOID:2462 MSH:D020252 NCI:C84724 SNOMEDCT_2010_1_31:412795008 SNOMEDCT_2010_1_31:43935004 UMLS_CUI:C0267211 Watermelon stomach (disorder) gastric antral vascular ectasia (disorder) disease_ontology DOID:2493 gastric antral vascular ectasia DOID:2493 DOID:12071 MSH:D016888 SNOMEDCT_2010_1_31:71072006 UMLS_CUI:C0085411 UMLS_CUI:C0156091 angiodysplasia of stomach and duodenum with hemorrhage disease_ontology DOID:2494 angiodysplasia DOID:2494 NCI:C5432 UMLS_CUI:C1334237 intracranial Cavernoma disease_ontology DOID:2516 intracranial cavernous angioma DOID:2516 ICD9CM:228.02 NCI:C3633 SNOMEDCT_2010_1_31:189196005 SNOMEDCT_2010_1_31:93468003 UMLS_CUI:C0154050 Angioma of intracranial Structure hemangioma of intracranial structure (disorder) hemangioma of intracranial structures hemangioma of intracranial structures (disorder) disease_ontology DOID:2517 intracranial structure hemangioma DOID:2517 ICD9CM:228.04 NCI:C3635 SNOMEDCT_2010_1_31:189197001 SNOMEDCT_2010_1_31:93467008 UMLS_CUI:C0154052 hemangioma of intra-abdominal structure (disorder) hemangioma of intra-abdominal structures hemangioma of intra-abdominal structures (disorder) hemangioma, Intra-abdominal disease_ontology DOID:254 hemangioma of intra-abdominal structure DOID:254 ICD9CM:228.0 ICD9CM:228.00 MSH:D006391 NCI:C3085 SNOMEDCT_2010_1_31:154625006 SNOMEDCT_2010_1_31:189192007 SNOMEDCT_2010_1_31:189193002 SNOMEDCT_2010_1_31:189194008 SNOMEDCT_2010_1_31:189199003 SNOMEDCT_2010_1_31:189863005 SNOMEDCT_2010_1_31:2099007 SNOMEDCT_2010_1_31:253053003 SNOMEDCT_2010_1_31:254822005 SNOMEDCT_2010_1_31:269646001 SNOMEDCT_2010_1_31:367337005 SNOMEDCT_2010_1_31:400210000 SNOMEDCT_2010_1_31:93474003 UMLS_CUI:C0018916 disease_ontology DOID:255 hemangioma DOID:255 MSH:D020293 NCI:C34653 UMLS_CUI:C0018202 disease_ontology DOID:2555 granulomatous angiitis DOID:2555 NCI:C3869 SNOMEDCT_2010_1_31:235879002 SNOMEDCT_2010_1_31:93469006 UMLS_CUI:C0238246 Angioma of Liver hepatic angioma (disorder) disease_ontology DOID:271 hemangioma of liver DOID:271 NCI:C35442 SNOMEDCT_2010_1_31:235878005 UMLS_CUI:C0400923 vascular disorder of liver (disorder) disease_ontology DOID:272 hepatic vascular disease DOID:272 MSH:D001157 SNOMEDCT_2010_1_31:2929001 UMLS_CUI:C0003838 Arterial occlusive disease disease_ontology DOID:2868 arterial occlusive disease DOID:2868 MSH:D012078 UMLS_CUI:C0035066 renal artery obstruction disease_ontology DOID:2972 renal artery obstruction DOID:2972 A vasculitits that is systemic vasculitis realized as blood vessel inflammation and has_symptom asthma along with hay fever, rash and gastrointestinal bleeding. MSH:C531653 MSH:D015267 NCI:C34481 SNOMEDCT_2010_1_31:195362002 SNOMEDCT_2010_1_31:82275008 UMLS_CUI:C0008728 Allergic Granulomatous Angiitis Allergic granulomatosis angiitis (disorder) Churg-Strauss vasculitis disease_ontology DOID:3049 Churg-Strauss syndrome DOID:3049 MSH:D002573 SNOMEDCT_2010_1_31:413577001 SNOMEDCT_2010_1_31:54995001 SNOMEDCT_2010_1_31:95409006 UMLS_CUI:C0007856 Arterial thoracic outlet syndrome due to cervical rib disease_ontology DOID:3102 cervical rib syndrome DOID:3102 MSH:D013901 NCI:C85188 SNOMEDCT_2010_1_31:128210009 SNOMEDCT_2010_1_31:193106006 SNOMEDCT_2010_1_31:193107002 SNOMEDCT_2010_1_31:193108007 SNOMEDCT_2010_1_31:2040007 SNOMEDCT_2010_1_31:212769008 SNOMEDCT_2010_1_31:393578000 UMLS_CUI:C0039984 TOS - Thoracic outlet syndrome disease_ontology DOID:3103 thoracic outlet syndrome DOID:3103 An ischemia occurring in the spinal cord. MSH:D020760 SNOMEDCT_2010_1_31:371029002 UMLS_CUI:C0752130 Ischaemic disorder of spinal cord disease_ontology DOID:324 spinal cord ischemia DOID:324 MSH:D020758 UMLS_CUI:C0752127 disease_ontology DOID:325 spinal cord vascular disease DOID:325 A pathological process of restriction in blood supply to tissues, causing a shortage of oxygen and glucose needed for cellular metabolism. MSH:D007511 NCI:C34738 SNOMEDCT_2010_1_31:52674009 UMLS_CUI:C0022116 ischemia disease_ontology DOID:326 ischemia DOID:326 ICD9CM:414.11 MSH:D003323 SNOMEDCT_2010_1_31:373139003 SNOMEDCT_2010_1_31:50570003 UMLS_CUI:C0010051 Aneurysm of coronary vessels Aneurysmal lesion of coronary artery Arteriovenous aneurysm of coronary vessels disease_ontology DOID:3362 coronary aneurysm coronary aneurysm disease DOID:3362 ICD9CM:414.0 MSH:D003324 NCI:C35505 SNOMEDCT_2010_1_31:155315001 SNOMEDCT_2010_1_31:155316000 SNOMEDCT_2010_1_31:194795001 SNOMEDCT_2010_1_31:194841001 SNOMEDCT_2010_1_31:266231003 SNOMEDCT_2010_1_31:266290000 SNOMEDCT_2010_1_31:41702007 SNOMEDCT_2010_1_31:53741008 UMLS_CUI:C0010054 disease_ontology DOID:3363 coronary arteriosclerosis DOID:3363 An ischemic heart disease with narrowing of the coronary arteries. MSH:D003327 NCI:C26732 SNOMEDCT_2010_1_31:41702007 SNOMEDCT_2010_1_31:53741008 UMLS_CUI:C0010068 CHD (coronary heart disease) CHD - Coronary heart disease Coronary disease disease_ontology DOID:3393 coronary heart disease DOID:3393 A disease characterized by reduced blood supply to the heart, occasioning pathological processes in the heart. An extrinsic cardiomyopathy that is characterized by reduced blood supply to the cardiac muscles. DOID:10506 DOID:9420 ICD9CM:410-414.99 ICD9CM:414.9 MSH:D017202 NCI:C50625 SNOMEDCT_2010_1_31:155303000 SNOMEDCT_2010_1_31:155315001 SNOMEDCT_2010_1_31:155318004 SNOMEDCT_2010_1_31:155322009 SNOMEDCT_2010_1_31:194795001 SNOMEDCT_2010_1_31:194852007 SNOMEDCT_2010_1_31:194878003 SNOMEDCT_2010_1_31:195540001 SNOMEDCT_2010_1_31:233822007 SNOMEDCT_2010_1_31:2610009 SNOMEDCT_2010_1_31:266290000 SNOMEDCT_2010_1_31:266291001 SNOMEDCT_2010_1_31:271430002 SNOMEDCT_2010_1_31:32598000 SNOMEDCT_2010_1_31:413838009 SNOMEDCT_2010_1_31:413844008 SNOMEDCT_2010_1_31:414545008 SNOMEDCT_2010_1_31:414795007 SNOMEDCT_2010_1_31:41702007 SNOMEDCT_2010_1_31:84537008 UMLS_CUI:C0151744 UMLS_CUI:C0264694 chronic myocardial ischaemia myocardial ischemia disease_ontology DOID:3394 ischemic heart disease DOID:3394 MSH:D002340 NCI:C84476 SNOMEDCT_2010_1_31:371160000 UMLS_CUI:C0007273 disorder of carotid artery (disorder) disease_ontology DOID:3407 carotid artery disease DOID:3407 ICD9CM:443.81 SNOMEDCT_2010_1_31:195624006 UMLS_CUI:C0031115 disease_ontology DOID:341 peripheral vascular disease DOID:341 A thrombosis occurring in a carotid artery. MSH:D002341 SNOMEDCT_2010_1_31:195181000 SNOMEDCT_2010_1_31:86003009 UMLS_CUI:C0007274 Carotid artery thrombosis Carotid artery thrombosis (disorder) disease_ontology DOID:3410 carotid artery thrombosis DOID:3410 ICD9CM:442.82 SNOMEDCT_2010_1_31:40136003 UMLS_CUI:C0155746 disease_ontology DOID:342 subclavian artery aneurysm subclavian artery aneurysm disease DOID:342 MSH:D020520 UMLS_CUI:C0751955 disease_ontology DOID:3454 An infarction occurring in the brain. brain infarction DOID:3454 A pathological process of disturbance in the blood supply to the brain, causing a loss of brain function. MSH:D020521 NCI:C3390 OMIM:601367 SNOMEDCT_2010_1_31:155388006 SNOMEDCT_2010_1_31:155405006 SNOMEDCT_2010_1_31:195208004 SNOMEDCT_2010_1_31:230690007 SNOMEDCT_2010_1_31:266312006 SNOMEDCT_2010_1_31:266315008 SNOMEDCT_2010_1_31:270883006 SNOMEDCT_2010_1_31:313267000 SNOMEDCT_2010_1_31:82797006 UMLS_CUI:C0038454 CVA (cerebral vascular accident) CVA - Cerebrovascular accident unspecified Cerebrovascular accident (disorder) Cerebrovascular accident (disorder) [Ambiguous] disease_ontology Stroke DOID:3455 OMIM mapping confirmed by DO. [SN]. cerebrovascular accident DOID:3455 MSH:D014854 NCI:C84807 SNOMEDCT_2010_1_31:195193009 SNOMEDCT_2010_1_31:78569004 UMLS_CUI:C0043019 Posterior inferior cerebellar artery syndrome (disorder) Wallenberg syndrome disease_ontology DOID:3522 lateral medullary syndrome DOID:3522 MSH:D020526 SNOMEDCT_2010_1_31:195191006 SNOMEDCT_2010_1_31:195192004 SNOMEDCT_2010_1_31:230697005 SNOMEDCT_2010_1_31:95457000 UMLS_CUI:C0521542 Brainstem infarction Brainstem infarction NOS Brainstem infarction NOS (disorder) brain stem infarction (disorder) disease_ontology DOID:3523 brain stem infarction DOID:3523 MSH:D020244 UMLS_CUI:C0740392 disease_ontology DOID:3525 middle cerebral artery infarction DOID:3525 MSH:D002544 NCI:C50486 SNOMEDCT_2010_1_31:155405006 SNOMEDCT_2010_1_31:195188006 SNOMEDCT_2010_1_31:195191006 SNOMEDCT_2010_1_31:20059004 SNOMEDCT_2010_1_31:266256009 SNOMEDCT_2010_1_31:266315008 SNOMEDCT_2010_1_31:432504007 UMLS_CUI:C0007785 CVA - Cerebral infarction Cerebral infarct Cerebral infarction Cerebral infarction NOS Cerebral infarction NOS (disorder) disease_ontology DOID:3526 cerebral infarction DOID:3526 MSH:D002539 UMLS_CUI:C0007774 disease_ontology DOID:3527 cerebral arterial disease DOID:3527 MSH:D020243 UMLS_CUI:C0751843 disease_ontology DOID:3528 anterior cerebral artery infarction DOID:3528 A thrombosis that occurs in a dural venous sinus. MSH:D012851 UMLS_CUI:C0037198 disease_ontology DOID:3572 intracranial sinus thrombosis DOID:3572 A thrombosis that occurs in a transverse sinus. MSH:D020227 SNOMEDCT_2010_1_31:192761004 SNOMEDCT_2010_1_31:21258007 UMLS_CUI:C0270639 Thrombosis of lateral venous sinus (disorder) Thrombosis transverse sinus (disorder) disease_ontology DOID:3574 lateral sinus thrombosis DOID:3574 A thrombosis that occurs in a cavernous sinus. MSH:D020226 SNOMEDCT_2010_1_31:89980009 UMLS_CUI:C0238454 Thrombosis of cavernous venous sinus (disorder) disease_ontology DOID:3575 cavernous sinus thrombosis DOID:3575 MSH:D020225 SNOMEDCT_2010_1_31:192760003 SNOMEDCT_2010_1_31:70607008 UMLS_CUI:C0338575 Thrombosis of superior longitudinal sinus (disorder) Thrombosis of superior sagittal sinus (disorder) disease_ontology DOID:3576 sagittal sinus thrombosis DOID:3576 MSH:D001014 NCI:C26697 SNOMEDCT_2010_1_31:155419006 SNOMEDCT_2010_1_31:155424009 SNOMEDCT_2010_1_31:195269009 SNOMEDCT_2010_1_31:67362008 UMLS_CUI:C0003486 disease_ontology DOID:3627 aortic aneurysm aortic aneurysm disease DOID:3627 MSH:D007383 SNOMEDCT_2010_1_31:155430009 SNOMEDCT_2010_1_31:195312007 SNOMEDCT_2010_1_31:63491006 UMLS_CUI:C0021775 Charcot's syndrome Intermittent claudication Intermittent claudication (disorder) Intermittent claudication NOS disease_ontology DOID:3669 intermittent claudication DOID:3669 MSH:D020762 UMLS_CUI:C0752132 disease_ontology DOID:3821 posterior cerebral artery infarction DOID:3821 MSH:D012790 SNOMEDCT_2010_1_31:24453002 UMLS_CUI:C0037018 Shwartzman phenomenon Shwartzman reaction (function) disease_ontology DOID:3825 Shwartzman phenomenon DOID:3825 MSH:D014927 NCI:C35132 OMIM:194200 SNOMEDCT_2010_1_31:155360000 SNOMEDCT_2010_1_31:251115003 SNOMEDCT_2010_1_31:266304003 SNOMEDCT_2010_1_31:74390002 UMLS_CUI:C0043202 Wolff Parkinson White syndrome Wolff-Park-White syndr. Wolff-Parkinson-White pattern (disorder) Wolff-Parkinson-White pattern (finding) Wolff-Parkinson-White syndrome disease_ontology DOID:384 Wolff-Parkinson-White syndrome DOID:384 DOID:1146 MSH:D013924 NCI:C3410 SNOMEDCT_2010_1_31:195401008 SNOMEDCT_2010_1_31:195433004 SNOMEDCT_2010_1_31:266266001 SNOMEDCT_2010_1_31:40283005 SNOMEDCT_2010_1_31:64156001 UMLS_CUI:C0040046 UMLS_CUI:C0265057 Phlebitis and thrombophlebitis of superficial vessels of lower extremities Superficial thrombophlebitis of leg Superficial thrombophlebitis of leg (disorder) Thrombophlebitis (disorder) Thrombophlebitis NOS (disorder) Thrombophlebitis of a superficial leg vein NOS (disorder) Thrombophlebitis of superficial veins of lower extremity (disorder) thrombophlebitis disease_ontology DOID:3875 thrombophlebitis DOID:3875 MSH:D000868 SNOMEDCT_2010_1_31:157669006 SNOMEDCT_2010_1_31:212379008 SNOMEDCT_2010_1_31:269407005 UMLS_CUI:C0003152 Anterior compartment syndrome disease_ontology DOID:3933 anterior compartment syndrome DOID:3933 A myocarditis with an acute disease course. ICD9CM:422 ICD9CM:422.90 NCI:C35206 SNOMEDCT_2010_1_31:155336004 SNOMEDCT_2010_1_31:194953001 SNOMEDCT_2010_1_31:194961006 SNOMEDCT_2010_1_31:195569005 SNOMEDCT_2010_1_31:46701001 UMLS_CUI:C0155686 disease_ontology DOID:3951 acute myocarditis DOID:3951 A restrictive cardiomyopathy that affects the endocardium and occurs with white blood cell proliferation, specifically of eosinophils. NCI:C27044 SNOMEDCT_2010_1_31:33258008 UMLS_CUI:C0264834 Eosinophilic Endomyocardial disease disease_ontology DOID:396 Loeffler endocarditis DOID:396 A cardiomyopathy (2008) characterized by increased stiffness of the left ventricular myocardium and decreased compliance of the left ventricle (which is restricted from stretching and filling with blood properly), in the absence of dilated cardiomyopathy and hypertrophic cardiomyopathy. MSH:D002313 NCI:C62798 SNOMEDCT_2010_1_31:389996009 SNOMEDCT_2010_1_31:415295002 SNOMEDCT_2010_1_31:90828009 UMLS_CUI:C0007196 Cardiomyopathy, constrictive Restrictive cardiomyopathy Restrictive cardiomyopathy (disorder) primary restrictive cardiomyopathy (disorder) disease_ontology DOID:397 restrictive cardiomyopathy DOID:397 MSH:C536366 NCI:C3926 SNOMEDCT_2010_1_31:11790000 SNOMEDCT_2010_1_31:195382003 SNOMEDCT_2010_1_31:49465005 UMLS_CUI:C0263637 Angioma Serpiginosum Angioma serpiginosum (disorder) Angioma serpiginosum of skin disease_ontology DOID:4028 angioma serpiginosum DOID:4028 A disease in which some disorder of a tricuspid valve prevents it from opening properly during right ventricular diastole, occasioning disturbance in the anterograd blood flow through the valve. A heart valve disease which results in the narrowing of the orifice of the tricuspid valve of the heart. This causes increased resistance to blood flow through the valve. It is almost always caused by rheumatic fever and is generally accompanied by mitral stenosis. Rare other causes include carcinoid syndrome, endocarditis, endomyocardial fibrosis, lupus erythematosus, right atrial myxoma and congenital tricuspid atresia. MSH:D014264 NCI:C50783 SNOMEDCT_2010_1_31:155346002 SNOMEDCT_2010_1_31:266296006 SNOMEDCT_2010_1_31:49915006 UMLS_CUI:C0040963 Tricuspid stenosis Tricuspid valve stenosis (disorder) disease_ontology DOID:4078 tricuspid valve stenosis DOID:4078 A disease affecting a valve of the heart. Heart valve disease is a heart disease described as any disease process involving one or more of the valves of the heart (the aortic and mitral valves on the left and the pulmonary and tricuspid valves on the right). Valve problems may be congenital (inborn) or acquired (due to another cause later in life). MSH:D006349 NCI:C45525 SNOMEDCT_2010_1_31:195013005 SNOMEDCT_2010_1_31:368009 UMLS_CUI:C0018824 Valvular heart disease (disorder) disease_ontology DOID:4079 heart valve disease DOID:4079 A disease in which an abnormal structure in a mitral valve prevents it to close propertly during systole, occasioning a retrograd blood flow through the valve. A heart valve disease where the heart's tricuspid valve fails to close properly during systole. As a result, with each heart beat, blood is pumped out from the right side of the heart in the opposite direction to normal. MSH:D014262 NCI:C50842 NCI:C50843 SNOMEDCT_2010_1_31:111287006 SNOMEDCT_2010_1_31:155347006 SNOMEDCT_2010_1_31:251009000 SNOMEDCT_2010_1_31:266298007 UMLS_CUI:C0040961 Tricuspid incompetence Tricuspid regurgitation Tricuspid valve regurgitation (disorder) disease_ontology DOID:4080 tricuspid valve insufficiency DOID:4080 A thrombosis occurring in the brain. DOID:12751 ICD9CM:434.0 MSH:D020767 SNOMEDCT_2010_1_31:155401002 UMLS_CUI:C0079102 UMLS_CUI:C0752143 cerebral thrombosis disease_ontology DOID:4193 intracranial thrombosis DOID:4193 MSH:D023903 UMLS_CUI:C0948480 disease_ontology DOID:4247 coronary restenosis DOID:4247 A disorder of atheromous plaques in a coronary artery. MSH:D023921 NCI:C80427 SNOMEDCT_2010_1_31:233970002 UMLS_CUI:C0242231 Coronary artery stenosis (disorder) disease_ontology DOID:4248 coronary stenosis DOID:4248 DOID:1957 DOID:1958 ICD9CM:434.1 MSH:D020766 SNOMEDCT_2010_1_31:155402009 SNOMEDCT_2010_1_31:75543006 UMLS_CUI:C0007780 UMLS_CUI:C0752140 Cerebral embolism with cerebral infarction cerebral embolism disease_ontology DOID:4372 intracranial embolism DOID:4372 A bacterial endocarditis characterized by a slow process of infection. MSH:D004698 NCI:C34583 SNOMEDCT_2010_1_31:155334001 SNOMEDCT_2010_1_31:194923008 SNOMEDCT_2010_1_31:50194006 SNOMEDCT_2010_1_31:73774007 UMLS_CUI:C0014122 Endocarditis lenta SBE - Subacute bacterial endocarditis Subacute bacterial endocarditis Subacute bacterial endocarditis (disorder) Subacute endocarditis, lenta disease_ontology DOID:4562 subacute bacterial endocarditis DOID:4562 NCI:C4905 SNOMEDCT_2010_1_31:189195009 SNOMEDCT_2010_1_31:254773009 SNOMEDCT_2010_1_31:93471006 UMLS_CUI:C0687140 Angioma of the skin Angiomatous naevus of skin hemangioma of skin (disorder) skin hemangioma disease_ontology DOID:471 skin hemangioma DOID:471 MSH:D006392 NCI:C3086 SNOMEDCT_2010_1_31:157014007 SNOMEDCT_2010_1_31:189192007 SNOMEDCT_2010_1_31:254781005 SNOMEDCT_2010_1_31:33377007 SNOMEDCT_2010_1_31:416824008 SNOMEDCT_2010_1_31:56975005 SNOMEDCT_2010_1_31:67668002 UMLS_CUI:C0018920 Cavernoma Cavernous haemangioma (disorder) Cavernous hemangioma (morphologic abnormality) disease_ontology DOID:483 cavernous hemangioma DOID:483 MSH:D020141 SNOMEDCT_2010_1_31:21112004 UMLS_CUI:C0600502 disease_ontology DOID:484 vascular hemostatic disease DOID:484 MSH:D001162 SNOMEDCT_2010_1_31:361133006 SNOMEDCT_2010_1_31:60625000 UMLS_CUI:C0003851 Arteriosclerosis obliterans (disorder) Arteriosclerosis obliterans (disorder) [Ambiguous] disease_ontology DOID:5160 arteriosclerosis obliterans DOID:5160 UMLS_CUI:C0544830 disease_ontology DOID:5161 Monckeberg arteriosclerosis DOID:5161 MSH:D050379 NCI:C35543 SNOMEDCT_2010_1_31:17941002 UMLS_CUI:C0878486 Arteriolosclerosis (morphologic abnormality) disease_ontology DOID:5162 arteriolosclerosis DOID:5162 A disease characterized by an inflammation of the aorta. MSH:D001025 SNOMEDCT_2010_1_31:195368003 SNOMEDCT_2010_1_31:70933002 UMLS_CUI:C0003509 Aortitis (disorder) Aortitis NOS disease_ontology DOID:519 aortitis DOID:519 A disease affecting the aorta. MSH:D001018 SNOMEDCT_2010_1_31:47040006 UMLS_CUI:C0003493 aortic disorder disorder of the aorta (disorder) disease_ontology DOID:520 aortic disease DOID:520 A disease characterized by the displacement of a degenerated aortic valve leaflet into the left ventricle during diastole. MSH:D001023 UMLS_CUI:C0003505 disease_ontology DOID:5232 aortic valve prolapse DOID:5232 MSH:D020293 NCI:C84622 UMLS_CUI:C0751878 disease_ontology DOID:525 central nervous system vasculitis DOID:525 NCI:C7739 UMLS_CUI:C0238814 disease_ontology DOID:5393 brain angioma DOID:5393 Aortic incompetence is a aortic valve disease where leakage of blood from the aorta back into the left ventricle during diastole because of failure of an aortic valve to close properly. ICD9CM:396.3 SNOMEDCT_2010_1_31:194736003 SNOMEDCT_2010_1_31:59464004 UMLS_CUI:C0264774 disease_ontology Corrigan's disease DOID:54 aortic incompetence DOID:54 MSH:D011668 NCI:C85039 OMIM:265450 SNOMEDCT_2010_1_31:89420002 UMLS_CUI:C0034091 pulmonary veno-occlusive disease (disorder) disease_ontology DOID:5453 OMIM mapping confirmed by DO. [SN]. pulmonary venoocclusive disease DOID:5453 An aortic valve insufficiency due to rheumatic fever. ICD9CM:395.1 SNOMEDCT_2010_1_31:155283004 SNOMEDCT_2010_1_31:78031003 UMLS_CUI:C0155568 Rheumatic aortic insufficiency Rheumatic aortic regurgitation Rheumatic aortic regurgitation (disorder) Rheumatic aortic valve regurgitation disease_ontology DOID:55 rheumatic aortic valve insufficiency DOID:55 A disease characterized by the displacement of a degenerated tricuspid valve leaflet into the right atrium during systole. MSH:D014263 SNOMEDCT_2010_1_31:253383003 UMLS_CUI:C0040962 Tricuspid valve prolapse (disorder) disease_ontology DOID:5644 tricuspid valve prolapse DOID:5644 A disease in which an abnormal structure in an aortic valve prevents it to close propertly during diastole, occasioning a retrograd blood flow through the valve. Aortic valve insufficiency is a aortic valve disease where leaking of the aortic valve of the heart causes blood to flow in the reverse direction during ventricular diastole, from the aorta into the left ventricle. Aortic insufficiency can be due to abnormalities of either the aortic valve or the aortic root (the beginning of the aorta). MSH:D001022 NCI:C50861 NCI:C51223 SNOMEDCT_2010_1_31:60234000 UMLS_CUI:C0003504 Aortic valve regurgitation (disorder) aortic insufficiency aortic regurgitation disease_ontology DOID:57 aortic valve insufficiency DOID:57 ICD9CM:397.1 SNOMEDCT_2010_1_31:18687009 SNOMEDCT_2010_1_31:194747005 SNOMEDCT_2010_1_31:266283005 UMLS_CUI:C0155579 Rheumatic disease of pulmonary valve Rheumatic disease of pulmonary valve (disorder) Rheumatic pulmonary incompetence Rheumatic pulmonary valve disease NOS (disorder) disease_ontology DOID:5748 rheumatic pulmonary valve disease DOID:5748 A disease affecting the pulmonary valve of the heart. ICD9CM:424.3 NCI:C78579 SNOMEDCT_2010_1_31:195001000 SNOMEDCT_2010_1_31:76267008 UMLS_CUI:C0034087 pulmonary valve disorder disease_ontology DOID:5749 pulmonary valve disease DOID:5749 ICD9CM:394.1 SNOMEDCT_2010_1_31:155278007 SNOMEDCT_2010_1_31:155279004 SNOMEDCT_2010_1_31:266279005 SNOMEDCT_2010_1_31:31085000 UMLS_CUI:C0155563 Rheumatic mitral insufficiency Rheumatic mitral regurgitation Rheumatic mitral regurgitation (disorder) Rheumatic mitral valve regurgitation disease_ontology DOID:58 rheumatic mitral valve incompetence DOID:58 MSH:D021922 UMLS_CUI:C0012628 disease_ontology DOID:5804 discrete subaortic stenosis DOID:5804 This refers to a narrowing of the section of the left ventricle below the aortic valve; therefore, this was not classified as an aortic valve stenosis in CVDO. MSH:D001020 NCI:C85172 UMLS_CUI:C0003500 disease_ontology DOID:5805 subvalvular aortic stenosis DOID:5805 NCI:C36068 UMLS_CUI:C1142433 disease_ontology DOID:5843 posteroinferior myocardial infarction DOID:5843 An infarction occurring in the myocardium. MSH:D009203 NCI:C27996 SNOMEDCT_2010_1_31:155304006 SNOMEDCT_2010_1_31:194796000 SNOMEDCT_2010_1_31:22298006 SNOMEDCT_2010_1_31:233824008 SNOMEDCT_2010_1_31:266288001 SNOMEDCT_2010_1_31:66514008 UMLS_CUI:C0027051 Attack - heart MI - Myocardial infarction Myocardial Infarct Myocardial Infarctions Myocardial infarct Myocardial infarction Myocardial infarction (disorder) Myocardial infarction NOS heart attack disease_ontology DOID:5844 myocardial infarction DOID:5844 MSH:D056988 NCI:C35303 UMLS_CUI:C0262564 disease_ontology DOID:5845 anterolateral myocardial infarction DOID:5845 NCI:C35519 UMLS_CUI:C0746727 disease_ontology DOID:5846 septal myocardial infarction DOID:5846 NCI:C35399 SNOMEDCT_2010_1_31:194800006 UMLS_CUI:C0340319 Posterior myocardial infarction NOS (disorder) disease_ontology DOID:5847 posterior myocardial infarction DOID:5847 NCI:C36073 UMLS_CUI:C1168331 disease_ontology DOID:5848 apical myocardial infarction DOID:5848 NCI:C35305 UMLS_CUI:C0262568 disease_ontology DOID:5849 subendocardial myocardial infarction DOID:5849 MSH:D056989 NCI:C35398 NCI:C71070 SNOMEDCT_2010_1_31:194804002 UMLS_CUI:C0340305 Inferior myocardial infarction NOS (disorder) disease_ontology DOID:5850 inferior myocardial infarction DOID:5850 NCI:C35672 UMLS_CUI:C1112662 disease_ontology DOID:5851 posterolateral myocardial infarction DOID:5851 NCI:C35673 UMLS_CUI:C1112770 disease_ontology DOID:5852 inferolateral myocardial infarct DOID:5852 NCI:C35586 SNOMEDCT_2010_1_31:194801005 UMLS_CUI:C0340312 Lateral myocardial infarction NOS (disorder) disease_ontology DOID:5853 lateral myocardial infarction DOID:5853 NCI:C35400 SNOMEDCT_2010_1_31:194796000 SNOMEDCT_2010_1_31:233843008 UMLS_CUI:C0340324 Silent myocardial infarction Silent myocardial infarction (disorder) disease_ontology DOID:5854 silent myocardial infarction DOID:5854 MSH:D056988 NCI:C35304 UMLS_CUI:C0262565 disease_ontology DOID:5855 anteroseptal myocardial infarction DOID:5855 DOID:10961 DOID:1547 ICD9CM:433 ICD9CM:433.3 ICD9CM:433.9 UMLS_CUI:C0155722 UMLS_CUI:C0155725 UMLS_CUI:C0155727 disease_ontology Occlusion and stenosis of multiple and bilateral precerebral arteries occlusion and stenosis of precerebral artery DOID:5976 occlusion precerebral artery DOID:5976 A disease characterized by the inability of the heart to pump a sufficient amount of blood throughout the body. A heart disease that is characterized by any structural or functional cardiacdisorder that impairs the ability of the heart to fill with or pump a sufficient amount ofblood throughout the body. DOID:395 ICD9CM:428 ICD9CM:428.0 ICD9CM:428.9 MSH:D006333 NCI:C3080 NCI:C50577 SNOMEDCT_2010_1_31:155374007 SNOMEDCT_2010_1_31:155375008 SNOMEDCT_2010_1_31:155377000 SNOMEDCT_2010_1_31:195108009 SNOMEDCT_2010_1_31:195117009 SNOMEDCT_2010_1_31:266248006 SNOMEDCT_2010_1_31:266308000 SNOMEDCT_2010_1_31:42343007 SNOMEDCT_2010_1_31:84114007 UMLS_CUI:C0018801 UMLS_CUI:C0018802 CHF Cardiac Failure Congestive Congestive heart disease Weak heart disease_ontology DOID:6000 congestive heart failure DOID:6000 A disease affecting the mitral valve of the heart. DOID:59 ICD9CM:424.0 NCI:C78446 SNOMEDCT_2010_1_31:11851006 SNOMEDCT_2010_1_31:194729004 SNOMEDCT_2010_1_31:194982000 UMLS_CUI:C0026265 Mitral and aortic valve disease NOS (disorder) Mitral and aortic valve disease, unspecified disease of mitral and aortic valves disease of mitral and aortic valves (disorder) mitral valve disease disease_ontology DOID:61 mitral valve disease DOID:61 A disease affecting the aortic valve of the heart. DOID:56 ICD9CM:395.9 UMLS_CUI:C0155570 disease_ontology DOID:62 aortic valve disease DOID:62 A disease that has_material_basis_in genetic variations in the human genome. MSH:D030342 NCI:C3101 SNOMEDCT_2010_1_31:264530000 SNOMEDCT_2010_1_31:32895009 UMLS_CUI:C0019247 disease_ontology DOID:630 genetic disease DOID:630 A disease in which some disorder of a pulmonary valve prevents it from opening properly during right ventricular systole, occasioning disturbance in the anterograd blood flow through the valve. MSH:D011666 SNOMEDCT_2010_1_31:56786000 UMLS_CUI:C0034089 Pulmonic stenosis NOS Pulmonic valve stenosis (disorder) pulmonary stenosis NOS pulmonary stenosis, cause unspecified (disorder) pulmonary valve stenosis disease_ontology DOID:6420 pulmonary valve stenosis DOID:6420 MSH:D006976 NCI:C3120 SNOMEDCT_2010_1_31:155328008 SNOMEDCT_2010_1_31:266293003 SNOMEDCT_2010_1_31:70995007 UMLS_CUI:C0020542 pulmonary hypertension pulmonary hypertension (disorder) disease_ontology DOID:6432 pulmonary hypertension DOID:6432 NCI:C5433 UMLS_CUI:C0877388 hemangioma of Cerebrum disease_ontology DOID:6621 cerebral angioma DOID:6621 MSH:D020759 SNOMEDCT_2010_1_31:2972007 UMLS_CUI:C0221069 Anterior spinal artery occlusion syndrome (disorder) disease_ontology DOID:6712 anterior spinal artery syndrome DOID:6712 DOID:12214 DOID:8231 ICD9CM:430-438.99 ICD9CM:437.9 MSH:D002561 NCI:C2938 SNOMEDCT_2010_1_31:155388006 SNOMEDCT_2010_1_31:155412002 SNOMEDCT_2010_1_31:195249004 SNOMEDCT_2010_1_31:195595007 SNOMEDCT_2010_1_31:266312006 SNOMEDCT_2010_1_31:62914000 UMLS_CUI:C0007820 cerebrovascular disorder disease_ontology DOID:6713 cerebrovascular disease DOID:6713 ICD9CM:958.90 MSH:D003161 SNOMEDCT_2010_1_31:111245009 SNOMEDCT_2010_1_31:212379008 SNOMEDCT_2010_1_31:45781009 UMLS_CUI:C0009492 Compartment syndrome Compartment syndrome (disorder) Compartmental syndrome, NOS disease_ontology DOID:682 compartment syndrome DOID:682 ICD9CM:708.3 SNOMEDCT_2010_1_31:123093003 SNOMEDCT_2010_1_31:156430003 SNOMEDCT_2010_1_31:201263000 SNOMEDCT_2010_1_31:201265007 SNOMEDCT_2010_1_31:238685008 SNOMEDCT_2010_1_31:247473009 SNOMEDCT_2010_1_31:270885004 SNOMEDCT_2010_1_31:402410006 SNOMEDCT_2010_1_31:402601007 SNOMEDCT_2010_1_31:7632005 UMLS_CUI:C0343065 Dermatographic urticaria Dermographism Physical urticaria disease_ontology DOID:743 dermatographia DOID:743 ICD9CM:441.5 MSH:D001019 NCI:C27198 SNOMEDCT_2010_1_31:155423003 SNOMEDCT_2010_1_31:195264004 SNOMEDCT_2010_1_31:195615002 SNOMEDCT_2010_1_31:73067008 UMLS_CUI:C0741160 Aortic aneurysm of unspecified site, ruptured Aortic aneurysm of unspecified site, ruptured (disorder) Ruptured Aortic Aneurysm Ruptured aortic aneurysm (disorder) Ruptured aortic aneurysm NOS Ruptured aortic aneurysm NOS (disorder) disease_ontology DOID:7682 ruptured aortic aneurysm ruptured aortic aneurysm disease DOID:7682 ICD9CM:441.0 NCI:C26751 SNOMEDCT_2010_1_31:155420000 SNOMEDCT_2010_1_31:308546005 SNOMEDCT_2010_1_31:67076004 UMLS_CUI:C0012736 disease_ontology DOID:7683 dissecting aortic aneurysm dissecting aortic aneurysm disease DOID:7683 ICD9CM:441.3 NCI:C27046 SNOMEDCT_2010_1_31:14336007 UMLS_CUI:C0265012 Ruptured abdominal Aortic Aneurysm Ruptured abdominal aortic aneurysm (disorder) abdominal aortic aneurysm, ruptured disease_ontology DOID:7692 ruptured abdominal aortic aneurysm ruptured abdominal aortic aneurysm disease DOID:7692 MSH:D017544 NCI:C27000 OMIM:100070 SNOMEDCT_2010_1_31:155422008 SNOMEDCT_2010_1_31:233985008 UMLS_CUI:C0162871 AORTIC ANEURYSM, FAMILIAL ABDOMINAL 1 abdominal Aortic Aneurysm abdominal aortic aneurysm abdominal aortic aneurysm (disorder) disease_ontology DOID:7693 abdominal aortic aneurysm abdominal aortic aneurysm disease DOID:7693 ICD9CM:441.1 NCI:C27299 SNOMEDCT_2010_1_31:195258006 SNOMEDCT_2010_1_31:34365005 UMLS_CUI:C0265010 Ruptured Thoracic Aneurysm Ruptured thoracic aortic aneurysm (disorder) Thoracic aortic aneurysm which has ruptured (disorder) Thoracic aortic aneurysm, ruptured disease_ontology DOID:7703 ruptured thoracic aortic aneurysm ruptured thoracic aortic aneurysm disease DOID:7703 MSH:D014648 NCI:C35114 OMIM:192200 SNOMEDCT_2010_1_31:128060009 SNOMEDCT_2010_1_31:12856003 SNOMEDCT_2010_1_31:155468006 SNOMEDCT_2010_1_31:155482006 SNOMEDCT_2010_1_31:234053000 SNOMEDCT_2010_1_31:266331000 SNOMEDCT_2010_1_31:276504003 SNOMEDCT_2010_1_31:399989005 UMLS_CUI:C0042345 Varix (morphologic abnormality) Venous ectasia Venous varices (disorder) varices disease_ontology DOID:799 OMIM mapping confirmed by DO. [LS]. varicose veins DOID:799 ICD9CM:433.10 UMLS_CUI:C0375275 Occlusion and stenosis of carotid artery disease_ontology DOID:807 carotid artery occlusion DOID:807 NCI:C35786 SNOMEDCT_2010_1_31:37925008 UMLS_CUI:C0027060 Interstitial myocarditis (disorder) disease_ontology DOID:817 interstitial myocarditis DOID:817 A disease characterized by an inflammation of the myocardium. ICD9CM:429.0 MSH:D009205 NCI:C34831 SNOMEDCT_2010_1_31:155380004 SNOMEDCT_2010_1_31:195119007 SNOMEDCT_2010_1_31:251060004 SNOMEDCT_2010_1_31:50920009 UMLS_CUI:C0027059 Myocardial inflammation (finding) Myocarditis (disorder) Myocarditis NOS Myocarditis NOS (disorder) Myocarditis, unspecified myocarditis disease_ontology DOID:820 myocarditis DOID:820 A myocarditis caused by rheumatic fever. DOID:14025 DOID:14036 ICD9CM:391.9 NCI:C34985 SNOMEDCT_2010_1_31:155270000 SNOMEDCT_2010_1_31:194713007 SNOMEDCT_2010_1_31:194750008 SNOMEDCT_2010_1_31:195136004 SNOMEDCT_2010_1_31:266285003 SNOMEDCT_2010_1_31:312591002 SNOMEDCT_2010_1_31:367538001 SNOMEDCT_2010_1_31:4536006 SNOMEDCT_2010_1_31:8805001 UMLS_CUI:C0035440 UMLS_CUI:C0489959 Rheumatic degeneration of myocardium Rheumatic fever with myocarditis Rheumatic myocarditis Rheumatic myocarditis (disorder) Rheumatoid myocarditis (disorder) active rheumatic fever with myocarditis acute Rheumatic Myocarditis acute rheumatic carditis acute rheumatic myocarditis acute rheumatic myocarditis (disorder) acute rheumatic myocarditis (disorder) [Ambiguous] disease_ontology DOID:8481 rheumatic myocarditis DOID:8481 ICD9CM:362.34 NCI:C35193 SNOMEDCT_2010_1_31:193377008 SNOMEDCT_2010_1_31:87224000 UMLS_CUI:C0154840 Retinal transient arterial occlusion NOS (disorder) Transient arterial retinal occlusion (disorder) Transient retinal arterial occlusion disease_ontology DOID:8482 transient retinal arterial occlusion DOID:8482 MSH:D015356 NCI:C34978 SNOMEDCT_2010_1_31:232035005 UMLS_CUI:C0035302 Retinal artery occlusion (disorder) disease_ontology DOID:8483 retinal artery occlusion DOID:8483 ICD9CM:673 SNOMEDCT_2010_1_31:156273009 SNOMEDCT_2010_1_31:200284000 SNOMEDCT_2010_1_31:200320009 SNOMEDCT_2010_1_31:200321008 SNOMEDCT_2010_1_31:200326003 SNOMEDCT_2010_1_31:237341004 SNOMEDCT_2010_1_31:50286006 UMLS_CUI:C0157540 disease_ontology DOID:8512 puerperal pulmonary embolism DOID:8512 A cor pulmonale that has an acute disease course during which the right ventricle becomes dilated. 'Acute pulmonary heart disease' and 'Acute cor pulmonale' (two classes imported from DOID) are considered as equivalent in CVDO. ICD9CM:415 SNOMEDCT_2010_1_31:155324005 SNOMEDCT_2010_1_31:194880009 SNOMEDCT_2010_1_31:194884000 SNOMEDCT_2010_1_31:67189007 UMLS_CUI:C0155671 acute pulmonary heart disease (disorder) acute pulmonary heart disease NOS (disorder) disease_ontology DOID:8514 acute pulmonary heart disease DOID:8514 A disease characterized by a dilatation or hypertrophy of the myocardium of right ventricle of the heart as a response to increased resistance or high blood pressure in the lungs, involving a failure of the right side of the heart. Although the 1995 classification of cardiomyopathies did not include cor pulmonale, it should have included it, given the definition of cardiomyopathy it adopted. A congestive heart failure that involves a failure of the right side of the heart and is characterized by an enlargement of the right ventricle of the heart as a response to increased resistance or high blood pressure in the lungs. MSH:D011660 SNOMEDCT_2010_1_31:155323004 SNOMEDCT_2010_1_31:155329000 SNOMEDCT_2010_1_31:194879006 SNOMEDCT_2010_1_31:266294009 SNOMEDCT_2010_1_31:274096000 SNOMEDCT_2010_1_31:286952009 SNOMEDCT_2010_1_31:83291003 UMLS_CUI:C0034072 cardiopulmonary disease pulmonary heart disease disease_ontology DOID:8515 cor pulmonale DOID:8515 A pathological process consisting in a pulmonary embolism and an infarction that follows. ICD9CM:415.1 UMLS_CUI:C0034066 disease_ontology DOID:8516 pulmonary embolism and infarction DOID:8516 'Acute pulmonary heart disease' and 'Acute cor pulmonale' (two classes imported from DOID) are considered as equivalent in CVDO. ICD9CM:415.0 SNOMEDCT_2010_1_31:155325006 SNOMEDCT_2010_1_31:194881008 SNOMEDCT_2010_1_31:49584005 UMLS_CUI:C0155672 acute cor pulmonale (disorder) disease_ontology DOID:8517 acute cor pulmonale DOID:8517 A disease characterized by an inflammation of a vein. MSH:D010689 NCI:C38003 SNOMEDCT_2010_1_31:195432009 SNOMEDCT_2010_1_31:61599003 UMLS_CUI:C0031542 Phlebitis (disorder) Phlebitis NOS (disorder) phlebitis disease_ontology DOID:864 phlebitis DOID:864 A disease characterized by an inflammation of a blood vessel. A vascular disease that is an inflammatory destruction of blood vessels. MSH:D014657 NCI:C26912 SNOMEDCT_2010_1_31:195375002 SNOMEDCT_2010_1_31:266325003 SNOMEDCT_2010_1_31:31996006 SNOMEDCT_2010_1_31:393589007 UMLS_CUI:C0042384 Angiitis disease_ontology DOID:865 vasculitis DOID:865 ICD9CM:453 SNOMEDCT_2010_1_31:195435006 UMLS_CUI:C0155774 disease_ontology DOID:866 vein disease DOID:866 A dementia that involves impairments in cognitive function caused by problems in blood vessels that feed the brain. DOID:13915 MSH:D015161 NCI:C34522 SNOMEDCT_2010_1_31:154850006 SNOMEDCT_2010_1_31:191462009 SNOMEDCT_2010_1_31:192165000 SNOMEDCT_2010_1_31:192167008 SNOMEDCT_2010_1_31:192171006 SNOMEDCT_2010_1_31:268613002 SNOMEDCT_2010_1_31:429998004 SNOMEDCT_2010_1_31:56267009 UMLS_CUI:C0011263 UMLS_CUI:C0011269 Multi Infarct Dementia multifocal dementia disease_ontology DOID:8725 vascular dementia DOID:8725 A coronary heart disease with an acute disease course. DOID label 'intermediate coronary syndrome' was changed. ICD9CM:411.1 MSH:D000789 NCI:C66911 SNOMEDCT_2010_1_31:155308009 SNOMEDCT_2010_1_31:155313008 SNOMEDCT_2010_1_31:155314002 SNOMEDCT_2010_1_31:194814006 SNOMEDCT_2010_1_31:194816008 SNOMEDCT_2010_1_31:194817004 SNOMEDCT_2010_1_31:194819001 SNOMEDCT_2010_1_31:233818002 SNOMEDCT_2010_1_31:233820004 SNOMEDCT_2010_1_31:25106000 SNOMEDCT_2010_1_31:4557003 SNOMEDCT_2010_1_31:59021001 SNOMEDCT_2010_1_31:64333001 UMLS_CUI:C0002965 (Angina: [crescendo] or [unstable] or [at rest]) or (preinfarction syndrome) or (impending infarction) Angina at rest Anginal chest pain at rest Impending infarction (disorder) Preinfarction angina Preinfarction angina (disorder) Unstable angina Worsening angina disease_ontology DOID:8805 acute coronary syndrome DOID:8805 DOID label 'pulmonary subvalvular stenosis' was changed for homogeneization with 'subvalvular aortic stenosis'. ICD9CM:746.83 MSH:D011662 NCI:C34961 SNOMEDCT_2010_1_31:204370002 SNOMEDCT_2010_1_31:3192005 UMLS_CUI:C0034084 Congenital Infundibular Stenosis Infundibular pulmonic stenosis (disorder) Infundibular pulmonic stenosis, congenital Subvalvular pulmonic stenosis pulmonary infundibular stenosis (disorder) pulmonary subvalvular stenosis disease_ontology DOID:8861 subvalvular pulmonary stenosis DOID:8861 MSH:D010382 SNOMEDCT_2010_1_31:197366003 SNOMEDCT_2010_1_31:240625009 SNOMEDCT_2010_1_31:58008004 UMLS_CUI:C0030781 hepatic peliosis (disorder) disease_ontology DOID:914 peliosis hepatis DOID:914 ICD9CM:443.82 MSH:D004916 NCI:C34593 SNOMEDCT_2010_1_31:238777005 SNOMEDCT_2010_1_31:37151006 UMLS_CUI:C0014804 Erythromelalgia (disorder) disease_ontology DOID:9240 erythromelalgia DOID:9240 ICD9CM:607.3 MSH:D011317 NCI:C85022 SNOMEDCT_2010_1_31:155930001 SNOMEDCT_2010_1_31:198027001 SNOMEDCT_2010_1_31:4287008 SNOMEDCT_2010_1_31:6273006 UMLS_CUI:C0033117 Mentulagra Priapism (disorder) disease_ontology DOID:9286 priapism DOID:9286 ICD9CM:443.21 SNOMEDCT_2010_1_31:230729006 UMLS_CUI:C0338585 Carotid artery dissection (disorder) Dissection of carotid artery disease_ontology DOID:9348 carotid artery dissection DOID:9348 ICD9CM:410.60 UMLS_CUI:C0155652 disease_ontology DOID:9407 strictly posterior acute myocardial infarction DOID:9407 ICD9CM:410 ICD9CM:410.9 ICD9CM:410.90 NCI:C35204 SNOMEDCT_2010_1_31:155304006 SNOMEDCT_2010_1_31:194796000 SNOMEDCT_2010_1_31:194811003 SNOMEDCT_2010_1_31:266288001 SNOMEDCT_2010_1_31:57054005 UMLS_CUI:C0155626 disease_ontology DOID:9408 acute myocardial infarction DOID:9408 MSH:D019586 NCI:C84791 SNOMEDCT_2010_1_31:155052007 SNOMEDCT_2010_1_31:267701004 SNOMEDCT_2010_1_31:271719001 SNOMEDCT_2010_1_31:28073009 UMLS_CUI:C0151740 Raised intracranial pressure disease_ontology DOID:9428 intracranial hypertension DOID:9428 An embolism that occurs in a pulmonary artery. MSH:D011655 NCI:C50713 SNOMEDCT_2010_1_31:155326007 SNOMEDCT_2010_1_31:194882001 SNOMEDCT_2010_1_31:266292008 SNOMEDCT_2010_1_31:59282003 UMLS_CUI:C0034065 pulmonary artery embolism disease_ontology DOID:9477 pulmonary embolism DOID:9477 ICD9CM:709.1 MSH:D017445 NCI:C35254 SNOMEDCT_2010_1_31:11263005 SNOMEDCT_2010_1_31:201306008 SNOMEDCT_2010_1_31:267820009 UMLS_CUI:C0162819 disease_ontology DOID:9540 vascular skin disease DOID:9540 A congestive heart failure with impaired ejection fraction. ICD9CM:428.2 ICD9CM:428.20 MSH:D054143 SNOMEDCT_2010_1_31:417996009 UMLS_CUI:C1135191 disease_ontology DOID:9651 systolic heart failure DOID:9651 ICD9CM:422.93 SNOMEDCT_2010_1_31:31993003 UMLS_CUI:C0155691 disease_ontology DOID:9694 toxic myocarditis DOID:9694 ICD9CM:456.5 SNOMEDCT_2010_1_31:17406005 SNOMEDCT_2010_1_31:195481006 SNOMEDCT_2010_1_31:266271008 UMLS_CUI:C0155795 disease_ontology DOID:9742 pelvic varices DOID:9742 ICD9CM:455.4 SNOMEDCT_2010_1_31:155474006 SNOMEDCT_2010_1_31:157525008 SNOMEDCT_2010_1_31:211490002 SNOMEDCT_2010_1_31:26373009 SNOMEDCT_2010_1_31:269372002 UMLS_CUI:C0155784 External thrombosed haemorrhoids Thrombosed external hemorrhoids disease_ontology DOID:9745 perianal hematoma DOID:9745 ICD9CM:455 MSH:D006484 NCI:C26792 SNOMEDCT_2010_1_31:155469003 SNOMEDCT_2010_1_31:155477004 SNOMEDCT_2010_1_31:195472000 SNOMEDCT_2010_1_31:70153002 UMLS_CUI:C0019112 disease_ontology DOID:9746 hemorrhoid DOID:9746 ICD9CM:455.6 SNOMEDCT_2010_1_31:82985000 UMLS_CUI:C0041844 disease_ontology DOID:9749 internal hemorrhoid DOID:9749 MSH:D017682 UMLS_CUI:C0206146 disease_ontology DOID:9767 myocardial stunning DOID:9767 MSH:D006322 SNOMEDCT_2010_1_31:155317009 SNOMEDCT_2010_1_31:194847002 SNOMEDCT_2010_1_31:65340007 UMLS_CUI:C0018789 cardiac aneurysm disease_ontology DOID:9768 heart aneurysm DOID:9768 A congestive heart failure with preserved ejection fraction. ICD9CM:428.3 ICD9CM:428.30 MSH:D054144 SNOMEDCT_2010_1_31:418304008 UMLS_CUI:C1135196 disease_ontology DOID:9775 diastolic heart failure DOID:9775 ICD9CM:446.0 MSH:D010488 NCI:C26847 SNOMEDCT_2010_1_31:155441006 SNOMEDCT_2010_1_31:155445002 SNOMEDCT_2010_1_31:195347004 SNOMEDCT_2010_1_31:266323005 SNOMEDCT_2010_1_31:286960005 SNOMEDCT_2010_1_31:66121003 UMLS_CUI:C0031036 disease_ontology DOID:9810 polyarteritis nodosa DOID:9810 A disease characterized by the displacement of a degenerated mitral valve leaflet into the left atrium during systole. MSH:D008945 NCI:C50655 OMIM:157700 SNOMEDCT_2010_1_31:155386005 SNOMEDCT_2010_1_31:194977007 SNOMEDCT_2010_1_31:194980008 SNOMEDCT_2010_1_31:409712001 SNOMEDCT_2010_1_31:42069006 SNOMEDCT_2010_1_31:45023003 SNOMEDCT_2010_1_31:8074002 UMLS_CUI:C0026267 BARLOWS SYNDROME Floppy mitral valve disease_ontology DOID:988 OMIM mapping confirmed by DO. [SN]. mitral valve prolapse DOID:988 A disease characterized by the displacement of a degenerated heart valve leaflet during systole. MSH:D016127 SNOMEDCT_2010_1_31:398995000 UMLS_CUI:C0079485 Cardiac valve prolapse disease_ontology DOID:989 heart valve prolapse DOID:989 ICD9CM:447.4 SNOMEDCT_2010_1_31:9250002 UMLS_CUI:C0152098 Celiac artery compression syndrome disease_ontology DOID:9892 Marable's syndrome DOID:9892 A dilated cardiomyopathy resulting from a pregnancy. It presents typically between the last month of pregnancy and up to six months postpartum. DOID:11697 DOID:11980 ICD9CM:674.5 UMLS_CUI:C0877208 antepartum peripartum cardiomyopathy postpartum peripartum cardiomyopathy disease_ontology DOID:9997 peripartum cardiomyopathy DOID:9997 Ventricular myocardium fma FMA:12151 Myocardium of ventricle FMA:12151 Region of wall of heart which consists of endocardium, myocardium and epicardium that surrounds the cavity of a cardiac chamber. Cardiac chamber wall fma FMA:13256 Wall of cardiac chamber FMA:13256 Cardinal organ part which is bounded predominantly by bonafide boundaries. Examples: lobe of lung, osteon, acinus, submucosa, anterior leaflet of mitral valve, capsule of kidney, cortical bone, muscle fasciculus. fma FMA:14065 Organ component FMA:14065 Tissue which consists of cardiac myocytes surrounded by cardiac endomysium. Examples: Cardiac muscle tissue proper, conducting tissue of heart. fma FMA:14068 Cardiac muscle tissue FMA:14068 Vascular tree, the organ parts of which are veins. Examples: There are only three canonical instances, systemic venous tree (organ), pulmonary venous tree (organ) and portal venous tree (organ). fma FMA:14284 Venous tree organ FMA:14284 Common iliac venous tree fma FMA:14333 Common iliac vein FMA:14333 fma FMA:18883 External iliac vein FMA:18883 fma FMA:18884 Internal iliac vein FMA:18884 fma FMA:21185 Femoral vein FMA:21185 Tubular organ part, the wall and lumen of which are continuous with those of the ventricles of the heart, directly or indirectly through branches of the aorta and pulmonary trunk. Examples: bronchial artery, hepatic artery, coronary artery, truncus anterior of right pulmonary artery, aorta. Trunk of artery fma FMA:30313 Arterial trunk FMA:30313 Anatomical cluster which consists of all or some members of one or more organ subclasses which are grouped together according to some shared attributes. Examples: abdominal viscera, pelvic viscera. fma FMA:32406 Organ cluster FMA:32406 Hollow tree, the organ parts of which are arteries, veins or lymphatic vessels. Examples: systemic arterial tree (organ), portal venous tree (organ), thoracic duct tree. fma FMA:3710 Vascular tree FMA:3710 Trunk of aortic tree Trunk of systemic arterial tree fma FMA:3734 Aorta FMA:3734 Carotid artery Trunk of common carotid tree fma FMA:3939 Common carotid artery FMA:3939 Muscularis layer fma FMA:45634 Muscle layer FMA:45634 Vascular tree, the organ parts of which are arteries. Examples: There are only two canonical instances, systemic arterial tree (organ) and pulmonary arterial tree (organ). fma FMA:45840 Arterial tree organ FMA:45840 Anatomical structure, which has as its parts a heterogeneous collection of organs, organ parts, cells, cell parts or body part subdivisions that are adjacent to, or continuous with one another; does not constitute a cell part, cell, tissue, organ, organ system or organ system subdivision, cardinal body part, body part subdivision or anatomical junction. Examples: joint, adnexa of uterus, root of lung, renal pedicle, back. fma FMA:49443 Anatomical cluster FMA:49443 Ophthalmic arterial branch fma FMA:49872 Branch of ophthalmic artery FMA:49872 Central artery of retina Retinal artery Zinn's artery fma FMA:49879 Central retinal artery FMA:49879 Systemic artery which supplies the heart. Coronary arterial tree fma FMA:49893 Coronary artery FMA:49893 fma FMA:49918 Systemic arterial trunk FMA:49918 Subdivision of arterial tree (organ) which consists of branching sets of tubes (arterial trunk) that form a tree; together with other arterial trees (organ part), it constitutes an arterial tree (organ). Examples: pulmonary arterial tree, right coronary arterial tree, superior mesenteric tree. Arterial subtree Arterial tree organ part Arterial vessel fma FMA:50720 Artery FMA:50720 Vascular tree organ region fma FMA:50722 Region of vascular tree organ FMA:50722 Subdivision of venous tree (organ) which consists of branching sets of tubes (venous trunks) that form a tree; together with other venous trees (organ part), it constitutes a venous tree (organ). Examples: subclavian venous tree, jugular tree, extrahepatic portal tree, common iliac venous tree. Venous subtree Venous tree organ part Venous vessel fma FMA:50723 Vein FMA:50723 Cranial dural venous sinus Dural sinus fma FMA:50762 Dural venous sinus FMA:50762 Lateral sinus fma FMA:50763 Transverse sinus FMA:50763 fma FMA:50772 Cavernous sinus FMA:50772 Segment of neuraxis that has as its parts gray matter and white matter that surround the cerebral ventricular system; Examples: There is only one brain. fma FMA:50801 Brain FMA:50801 fma FMA:52568 Paired dural venous sinus FMA:52568 Organ component layer which consists of the endothelium and the fibroelastic connective tissue. fma FMA:55589 Tunica intima FMA:55589 Organ the unshared parts of which surround one or more macroscopic anatomical spaces. Examples: neuraxis, tooth, esophagus, heart, long bone, corpus spongiosum of penis. fma FMA:55671 Cavitated organ FMA:55671 Cavitated organ in which its unshared parts surround one continuous anatomical space. Examples: stomach, urinary bladder, esophagus, uterine tube. fma FMA:55672 Organ with organ cavity FMA:55672 Cavitated organ in which its unshared parts surround two or more macroscopic anatomical spaces. Examples: heart, long bone, corpus spongiosum of penis, bulb of vestibule. fma FMA:55673 Organ with cavitated organ parts FMA:55673 Organ with organ cavity, which consists of an arborizing set of tubular organ parts, the walls of which are continuous and surround a continuous lumen. Examples: systemic arterial tree (organ), tracheobronchial tree, biliary tree. fma FMA:55677 Hollow tree organ FMA:55677 fma FMA:6266 Subdivision of conducting system of heart FMA:6266 Subdivision of vascular tree (organ) which connects an arteriole to a venule or vice-versa. Blood capillary Capillary vessel fma FMA:63194 Capillary FMA:63194 Pulmonary arterial tree Pulmonary arterial tree organ part fma FMA:66326 Pulmonary artery FMA:66326 Systemic arterial subtree fma FMA:66464 Systemic artery FMA:66464 Systemic venous tree organ part fma FMA:66644 Systemic vein FMA:66644 Portal venous tree organ part fma FMA:66645 Portal vein FMA:66645 Material anatomical entity which is generated by coordinated expression of the organism's own genes that guide its morphogenesis; has inherent 3D shape; its parts are connected and spatially related to one another in patterns determined by coordinated gene expression. Examples: heart, right ventricle, mitral valve, myocardium, endothelium, lymphocyte, fibroblast, thorax, cardiovascular system, hemoglobin, T cell receptor. Biological structure fma FMA:67135 Anatomical structure FMA:67135 This class was relocated as a son of BFO 'Material entity', and BFO 2.0 'located in at all times' relations were added between relevant FMA classes; they should ultimately be replaced by a genuine version of FMA using BFO 2.0 relations. Physical anatomical entity which has mass. Examples: hemoglobin molecule, mitochondrion, hepatocyte, erythrocyte, heart, head, blood, urine. fma FMA:67165 Material anatomical entity FMA:67165 Anatomical structure which has as its direct parts portions of two or more types of tissue or two or more types of cardinal organ part which constitute a maximally connected anatomical structure demarcated predominantly by a bona fide anatomical surface. Examples: femur, biceps, liver, heart, skin, tracheobronchial tree, ovary. fma FMA:67498 Organ FMA:67498 fma FMA:67611 Anatomical valve FMA:67611 Cardinal organ part which is a fiat subdivision of an organ. Examples: lingula of left lung, tail of pancreas, artery, trochanter, nodulus of semilunar valve, right side of heart, duodenum, fundus of stomach. fma FMA:67619 Organ region FMA:67619 Tissue which consists of striated muscle fibers surrounded by endomysium. Examples: Skeletal muscle tissue, Cardiac muscle tissue. fma FMA:67905 Striated muscle tissue FMA:67905 Common carotid arterial subdivision fma FMA:70504 Subdivision of common carotid artery FMA:70504 Branch of internal carotid artery Internal carotid arterial subdivision fma FMA:70506 Subdivision of internal carotid artery FMA:70506 fma FMA:70523 Subdivision of cerebral part of internal carotid artery FMA:70523 fma FMA:7088 Heart FMA:7088 Organ chamber which consists of a wall that surrounds the cavity of a cardiac atrium or ventricle. Chamber of heart fma FMA:7095 Cardiac chamber FMA:7095 Right cardiac chamber which is continuous with the superior vena cava and inferior vena cava. Right atrium of heart fma FMA:7096 Right atrium FMA:7096 Left cardiac chamber which is continuous with the pulmonary venous trunk. Left atrium of heart fma FMA:7097 Left atrium FMA:7097 Right cardiac chamber which is continuous with the pulmonary arterial trunk. Right ventricle of heart fma FMA:7098 Right ventricle FMA:7098 Cardiac chamber which consists of a wall that surrounds the cavity of an atrium. Atrium of heart fma FMA:7099 Cardiac atrium FMA:7099 Cardiac chamber which consists of a wall that surrounds the cavity of a ventricle. Lower chamber of heart Ventricle of heart fma FMA:7100 Cardiac ventricle FMA:7100 Left cardiac chamber which is continuous with the aorta. Left ventricle of heart fma FMA:7101 Left ventricle FMA:7101 Anatomical valve which has as its parts the endocardium and fibroelastic connective tissue attached to the fibrous ring of heart. Heart valve Valve of heart fma FMA:7110 Cardiac valve FMA:7110 Anatomical structure, which has as its direct parts instances of one or more organ types which are interconnected with one another by zones of continuity. Examples: skeletal system, cardiovascular system, alimentary system. fma FMA:7149 Organ system FMA:7149 Organ system which consists of the heart, the systemic and pulmonary arterial and venous system, the lymphatic and the portal venous system. fma FMA:7161 Cardiovascular system FMA:7161 Cardiac valve which has as its parts the leaf of cardiac valve that separates the atrium from the ventricle. fma FMA:7233 Atrioventricular valve FMA:7233 Atrioventricular valve which has as its parts the anterior, posterior and septal leaflets, attached to the fibrous ring of tricuspid valve. Right atrioventricular valve fma FMA:7234 Tricuspid valve FMA:7234 Atrioventricular valve which has as its parts the anterior and posterior leaflets, attached to the fibrous ring of mitral valve. Bicuspid valve Left atrioventricular valve fma FMA:7235 Mitral valve FMA:7235 Cardiac valve which has as its parts the anterior, right posterior and left posterior cusps, attached to the fibrous ring of aortic valve. fma FMA:7236 Aortic valve FMA:7236 Cardiac valve which has as its parts the right anterior, left anterior and posterior cusps, attached to the fibrous ring of pulmonary valve. Pulmonic valve fma FMA:7246 Pulmonary valve FMA:7246 Tunica intima which has as its parts the endothelium of endocardium and the fibroelastic connective tissue that surrounds the cavity of a cardiac chamber. fma FMA:7280 Endocardium FMA:7280 Brachiocephalic venous subdivision Tributary of brachiocephalic vein fma FMA:77883 Subdivision of brachiocephalic vein FMA:77883 Superior vena caval tree subdivision fma FMA:78048 Subdivision of superior vena caval tree FMA:78048 Inferior vena caval tree subdivision fma FMA:78049 Subdivision of inferior vena caval tree FMA:78049 External iliac venous subdivision fma FMA:78204 Subdivision of external iliac vein FMA:78204 anatomical structure which has as its direct parts two or more types of tissue and is continuous with one or more anatomical structures likewise constituted by two or more portions of tissues distinct from those of their complement. Examples: osteon, cortical bone, neck of femur, bronchopulmonary segment, left lobe of liver, anterior right side of heart, interventricular branch of left coronary artery, right atrium, mitral valve, head of pancreas. fma FMA:82472 Cardinal organ part FMA:82472 fma FMA:82481 Organ chamber FMA:82481 fma FMA:82485 Organ component layer FMA:82485 Organ component which is part of the brain or spinal cord. fma FMA:83153 Organ component of neuraxis FMA:83153 Specialized conducting tissue of heart Specialized muscle tissue of heart fma FMA:83378 Conducting tissue of heart FMA:83378 fma FMA:85353 Muscle layer of organ FMA:85353 Myocardial zone Myocardium region Zone of myocardium fma FMA:86044 Region of myocardium FMA:86044 Cardinal organ part which is a fiat subdivision of an organ component. Examples: cervical part of wall of esophagus, mucosa of body of stomach. Organ component region fma FMA:86103 Region of organ component FMA:86103 Organ region with one or more anchored fiat boundaries. Examples: artery, trunk of nerve, cervical part of esophagus, pelvic part of vagina, horn of thyroid cartilage, anterior segment of eyeball. Organ region with fixed fiat boundary Segment of organ fma FMA:86140 Organ segment FMA:86140 Arterial tree organ segment fma FMA:86187 Segment of arterial tree organ FMA:86187 Venous tree organ segment fma FMA:86188 Segment of venous tree organ FMA:86188 fma FMA:86212 Region of wall of heart FMA:86212 Muscle layer of organ which has as its parts the myocardium proper and the conducting system of the heart. Heart muscle Muscle of heart fma FMA:9462 Myocardium FMA:9462 Myocardium of ventricle which is continuous with the tunica media of the pulmonary trunk. Right ventricular myocardium fma FMA:9535 Myocardium of right ventricle FMA:9535 Myocardium of ventricle which is continuous with the tunica media of aorta. Left ventricular myocardium fma FMA:9558 Myocardium of left ventricle FMA:9558 Anatomical structure which has as its parts cells of predominantly one type with or without intercellular matrix. Examples: epithelium, muscle tissue, connective tissue, neural tissue, lymphoid tissue. Tissue fma FMA:9637 Portion of tissue FMA:9637 Tissue which consists of muscle cells surrounded by a reticulum of collagen fibers or fine connective tissue [endomysium]. Examples: Smooth muscle, Cardiac muscle. Muscle tissue fma FMA:9641 Portion of muscle tissue FMA:9641 Organ with organ cavity, which has as parts a serous membrane and a serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa. fma FMA:9689 Serous sac FMA:9689 Serous sac, which has as parts the serous pericardium and the pericardial cavity . Examples: There is only one pericardial sac. fma FMA:9868 Pericardial sac FMA:9868 Organ cluster which has as its parts the fibrous pericardium and the pericardial sac. fma FMA:9869 Pericardium FMA:9869 OGMS:0000031 In order to obtain the taxonomy of diseases / disorders / pathological process in CVDO, it is necessary to use the reasoner first and to look at the inferred class hierarchy. A disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism. Albert Goldfain http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf creation date: 2009-06-23T11:21:20Z disease OGMS:0000045 A material entity which is clinically abnormal and part of an extended organism. Disorders are the physical basis of disease. Albert Goldfain http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf creation date: 2009-06-23T11:39:44Z disorder OGMS:0000047 A disorder whose etiology involves an abnormality in the nucleotide sequence of an organism's genome. Albert Goldfain http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf creation date: 2009-06-23T11:41:14Z genetic disorder OGMS:0000059 A process in an organism that leads to a subsequent disorder. Albert Goldfain http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf creation date: 2009-06-23T11:53:07Z etiological process OGMS:0000060 Albert Goldfain creation date: 2009-06-23T11:53:49Z bodily process OGMS:0000061 A bodily process that is clinically abnormal. Albert Goldfain http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf creation date: 2009-06-23T11:54:29Z pathological bodily process OGMS:0000063 The totality of all processes through which a given disease instance is realized. Albert Goldfain http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf creation date: 2009-06-23T11:55:44Z disease course OGMS:0000064 A disease course that (a) does not terminate in a return to normal homeostasis and (b) would, absent intervention, fall within abnormal homeostatic range. Albert Goldfain http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf creation date: 2009-06-23T11:56:26Z chronic disease course OGMS:0000065 A disease course that (a) does not terminate in a return to normal homeostasis and (b) would, absent intervention, involve an increasing deviation from homeostasis. Albert Goldfain http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf creation date: 2009-06-23T11:57:09Z progressive disease course OGMS:0000066 A disease course that terminates in a return to normal homeostasis. Albert Goldfain http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf creation date: 2009-06-23T11:57:44Z transient disease course OGMS:0000078 An anatomical structure (FMA) is pathological whenever (1) it has come into being as a result of changes in some pre-existing canonical anatomical structure, (2) through processes other than the expression of the normal complement of genes of an organism of the given type, and (3) is predisposed to have health-related consequences for the organism in question manifested by symptoms and signs. Albert Goldfain http://ontology.buffalo.edu/bio/ISMB/ISMB_Bio-ontologies.pdf creation date: 2009-07-13T02:14:05Z pathological anatomical structure OGMS:0000094 a disease course with a rapid onset but typical unfolding of signs and symptoms after this rapid onset. Albert Goldfain http://code.google.com/p/ogms/wiki/Meeting_notes_20100513 creation date: 2010-07-19T11:57:44Z acute disease course example to be eventually removed Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete. metadata complete term created to ease viewing/sort terms for development purpose, and will not be included in a release organizational term Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking "ready_for_release" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release. Those classes deemed "ready_for_release" will also derived from a chain of ancestor classes that are also "ready_for_release." ready for release Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors. metadata incomplete Nothing done yet beyond assigning a unique class ID and proposing a preferred term. uncurated All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the definition editor. pending final vetting Terms with this status should eventually replaced with a term from another ontology. Alan Ruttenberg group:OBI to be replaced with external ontology term A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues. Alan Ruttenberg group:OBI requires discussion 2024-05-17 Person:Alan Ruttenberg realized-in realizedIn [copied from inverse property 'realizes'] to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003]) if a realizable entity b is realized in a process p, then p stands in the has_participant relation to the bearer of b. (axiom label in BFO2 Reference: [106-002]) (forall (x y z t) (if (and (RealizableEntity x) (Process y) (realizesAt y x t) (bearerOfAt z x t)) (hasParticipantAt y z t))) // axiom label in BFO2 CLIF: [106-002] realized in if a realizable entity b is realized in a process p, then p stands in the has_participant relation to the bearer of b. (axiom label in BFO2 Reference: [106-002]) (forall (x y z t) (if (and (RealizableEntity x) (Process y) (realizesAt y x t) (bearerOfAt z x t)) (hasParticipantAt y z t))) // axiom label in BFO2 CLIF: [106-002] concretized-by_st [copied from inverse property 'concretizes at some time'] You may concretize a piece of software by installing it in your computer [copied from inverse property 'concretizes at some time'] You may concretize a recipe that you find in a cookbook by turning it into a plan which exists as a realizable dependent continuant in your head. [copied from inverse property 'concretizes at some time'] you may concretize a poem as a pattern of memory traces in your head [copied from inverse property 'concretizes at some time'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'concretizes at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'concretizes@en'(x,y,t) [copied from inverse property 'concretizes at some time'] b concretizes c at t means: b is a specifically dependent continuant & c is a generically dependent continuant & for some independent continuant that is not a spatial region d, b s-depends_on d at t & c g-depends on d at t & if c migrates from bearer d to another bearer e than a copy of b will be created in e. (axiom label in BFO2 Reference: [075-002]) concretized by at some time occurs-in occursIn CVDO adds the property chain that if A occurs_in B and B located_in_at_all_times C, then A occurs_in C. This is used for a few inferences in the ontology, but CVDO can be used without problem without this property chain. b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t [XXX-001 occurs in located-in_at locatedInAt Mary located_in Salzburg the Empire State Building located_in New York. this portion of cocaine located_in this portion of blood this stem cell located_in this portion of bone marrow your arm located_in your body b located_in c at t = Def. b and c are independent continuants, and the region at which b is located at t is a (proper or improper) continuant_part_of the region at which c is located at t. (axiom label in BFO2 Reference: [045-001]) Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'located in at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'located in@en(x,y,t)'. BFO2 Reference: independent continuant Located_in is transitive. (axiom label in BFO2 Reference: [046-001]) for all independent continuants b, c, and d: if b continuant_part_of c at t & c located_in d at t, then b located_in d at t. (axiom label in BFO2 Reference: [048-001]) for all independent continuants b, c, and d: if b located_in c at t & c continuant_part_of d at t, then b located_in d at t. (axiom label in BFO2 Reference: [049-001]) (forall (x y z t) (if (and (IndependentContinuant x) (IndependentContinuant y) (IndependentContinuant z) (continuantPartOfAt x y t) (locatedInAt y z t)) (locatedInAt x z t))) // axiom label in BFO2 CLIF: [048-001] (forall (x y z t) (if (and (IndependentContinuant x) (IndependentContinuant y) (IndependentContinuant z) (locatedInAt x y t) (continuantPartOfAt y z t)) (locatedInAt x z t))) // axiom label in BFO2 CLIF: [049-001] (forall (x y z t) (if (and (locatedInAt x y t) (locatedInAt y z t)) (locatedInAt x z t))) // axiom label in BFO2 CLIF: [046-001] (iff (locatedInAt a b t) (and (IndependentContinuant a) (IndependentContinuant b) (exists (r_1 r_2) (and (occupiesSpatialRegionAt a r_1 t) (occupiesSpatialRegionAt b r_2 t) (continuantPartOfAt r_1 r_2 t))))) // axiom label in BFO2 CLIF: [045-001] located in at all times b located_in c at t = Def. b and c are independent continuants, and the region at which b is located at t is a (proper or improper) continuant_part_of the region at which c is located at t. (axiom label in BFO2 Reference: [045-001]) Located_in is transitive. (axiom label in BFO2 Reference: [046-001]) for all independent continuants b, c, and d: if b continuant_part_of c at t & c located_in d at t, then b located_in d at t. (axiom label in BFO2 Reference: [048-001]) for all independent continuants b, c, and d: if b located_in c at t & c continuant_part_of d at t, then b located_in d at t. (axiom label in BFO2 Reference: [049-001]) (forall (x y z t) (if (and (IndependentContinuant x) (IndependentContinuant y) (IndependentContinuant z) (continuantPartOfAt x y t) (locatedInAt y z t)) (locatedInAt x z t))) // axiom label in BFO2 CLIF: [048-001] (forall (x y z t) (if (and (IndependentContinuant x) (IndependentContinuant y) (IndependentContinuant z) (locatedInAt x y t) (continuantPartOfAt y z t)) (locatedInAt x z t))) // axiom label in BFO2 CLIF: [049-001] (forall (x y z t) (if (and (locatedInAt x y t) (locatedInAt y z t)) (locatedInAt x z t))) // axiom label in BFO2 CLIF: [046-001] (iff (locatedInAt a b t) (and (IndependentContinuant a) (IndependentContinuant b) (exists (r_1 r_2) (and (occupiesSpatialRegionAt a r_1 t) (occupiesSpatialRegionAt b r_2 t) (continuantPartOfAt r_1 r_2 t))))) // axiom label in BFO2 CLIF: [045-001] located-at-r_st occupiesSpatialRegionAt Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'occupies spatial region at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'occupies spatial region@en'(x,y,t) BFO2 Reference: independent continuant BFO2 Reference: spatial region b occupies_spatial_region r at t means that r is a spatial region in which independent continuant b is exactly located (axiom label in BFO2 Reference: [041-002]) every region r is occupies_spatial_region r at all times. (axiom label in BFO2 Reference: [042-002]) if b occupies_spatial_region r at t & b continuant_part_of b at t, then there is some r which is continuant_part_of r at t such that b occupies_spatial_region r at t. (axiom label in BFO2 Reference: [043-001]) (forall (r t) (if (Region r) (occupiesSpatialRegionAt r r t))) // axiom label in BFO2 CLIF: [042-002] (forall (x r t) (if (occupiesSpatialRegionAt x r t) (and (SpatialRegion r) (IndependentContinuant x)))) // axiom label in BFO2 CLIF: [041-002] (forall (x y r_1 t) (if (and (occupiesSpatialRegionAt x r_1 t) (continuantPartOfAt y x t)) (exists (r_2) (and (continuantPartOfAt r_2 r_1 t) (occupiesSpatialRegionAt y r_2 t))))) // axiom label in BFO2 CLIF: [043-001] occupies spatial region at some time b occupies_spatial_region r at t means that r is a spatial region in which independent continuant b is exactly located (axiom label in BFO2 Reference: [041-002]) every region r is occupies_spatial_region r at all times. (axiom label in BFO2 Reference: [042-002]) if b occupies_spatial_region r at t & b continuant_part_of b at t, then there is some r which is continuant_part_of r at t such that b occupies_spatial_region r at t. (axiom label in BFO2 Reference: [043-001]) (forall (r t) (if (Region r) (occupiesSpatialRegionAt r r t))) // axiom label in BFO2 CLIF: [042-002] (forall (x r t) (if (occupiesSpatialRegionAt x r t) (and (SpatialRegion r) (IndependentContinuant x)))) // axiom label in BFO2 CLIF: [041-002] (forall (x y r_1 t) (if (and (occupiesSpatialRegionAt x r_1 t) (continuantPartOfAt y x t)) (exists (r_2) (and (continuantPartOfAt r_2 r_1 t) (occupiesSpatialRegionAt y r_2 t))))) // axiom label in BFO2 CLIF: [043-001] exists-at existsAt BFO2 Reference: entity BFO2 Reference: temporal region b exists_at t means: b is an entity which exists at some temporal region t. (axiom label in BFO2 Reference: [118-002]) exists at b exists_at t means: b is an entity which exists at some temporal region t. (axiom label in BFO2 Reference: [118-002]) has-material-basis_at hasMaterialBasisAt the material basis of John’s disposition to cough is the viral infection in John’s upper respiratory tract the material basis of the disposition to wear unevenly of John’s tires is the worn suspension of his car. Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'has material basis at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'has material basis@en(x,y,t)'. b has_material_basis c at t means: b is a disposition & c is a material entity & there is some d bearer_of b at t& c continuant_part_of d at t& d has_disposition b at t because c continuant_part_of d at t. (axiom label in BFO2 Reference: [071-002]) (forall (x y t) (if (hasMaterialBasisAt x y t) (and (Disposition x) (MaterialEntity y) (exists (z) (and (bearerOfAt z x t) (continuantPartOfAt y z t) (exists (w) (and (Disposition w) (if (hasDisposition z w) (continuantPartOfAt y z t))))))))) // axiom label in BFO2 CLIF: [071-002] has material basis at all times b has_material_basis c at t means: b is a disposition & c is a material entity & there is some d bearer_of b at t& c continuant_part_of d at t& d has_disposition b at t because c continuant_part_of d at t. (axiom label in BFO2 Reference: [071-002]) (forall (x y t) (if (hasMaterialBasisAt x y t) (and (Disposition x) (MaterialEntity y) (exists (z) (and (bearerOfAt z x t) (continuantPartOfAt y z t) (exists (w) (and (Disposition w) (if (hasDisposition z w) (continuantPartOfAt y z t))))))))) // axiom label in BFO2 CLIF: [071-002] o-has-part hasOccurrentPart [copied from inverse property 'part of occurrent'] Mary’s 5th birthday occurrent_part_of Mary’s life [copied from inverse property 'part of occurrent'] The process of a footballer’s heart beating once is an occurrent part but not a temporal_part of a game of football. [copied from inverse property 'part of occurrent'] the first set of the tennis match occurrent_part_of the tennis match. b has_occurrent_part c = Def. c occurrent_part_of b. (axiom label in BFO2 Reference: [007-001]) [copied from inverse property 'part of occurrent'] BFO 2 Reference: a (continuant or occurrent) part of itself. We appreciate that this is counterintuitive for some users, since it implies for example that President Obama is a part of himself. However it brings benefits in simplifying the logical formalism, and it captures an important feature of identity, namely that it is the limit case of mereological inclusion. [copied from inverse property 'part of occurrent'] BFO2 Reference: occurrent [copied from inverse property 'part of occurrent'] b occurrent_part_of c =Def. b is a part of c & b and c are occurrents. (axiom label in BFO2 Reference: [003-002]) (iff (hasOccurrentPart a b) (occurrentPartOf b a)) // axiom label in BFO2 CLIF: [007-001] has occurrent part b has_occurrent_part c = Def. c occurrent_part_of b. (axiom label in BFO2 Reference: [007-001]) (iff (hasOccurrentPart a b) (occurrentPartOf b a)) // axiom label in BFO2 CLIF: [007-001] o-part-of occurrentPartOf Mary’s 5th birthday occurrent_part_of Mary’s life The process of a footballer’s heart beating once is an occurrent part but not a temporal_part of a game of football. the first set of the tennis match occurrent_part_of the tennis match. [copied from inverse property 'has occurrent part'] b has_occurrent_part c = Def. c occurrent_part_of b. (axiom label in BFO2 Reference: [007-001]) BFO 2 Reference: a (continuant or occurrent) part of itself. We appreciate that this is counterintuitive for some users, since it implies for example that President Obama is a part of himself. However it brings benefits in simplifying the logical formalism, and it captures an important feature of identity, namely that it is the limit case of mereological inclusion. BFO2 Reference: occurrent b occurrent_part_of c =Def. b is a part of c & b and c are occurrents. (axiom label in BFO2 Reference: [003-002]) occurrent_part_of is antisymmetric. (axiom label in BFO2 Reference: [123-001]) occurrent_part_of is reflexive (every occurrent entity is an occurrent_part_of itself). (axiom label in BFO2 Reference: [113-002]) occurrent_part_of is transitive. (axiom label in BFO2 Reference: [112-001]) occurrent_part_of satisfies unique product. (axiom label in BFO2 Reference: [125-001]) occurrent_part_of satisfies weak supplementation. (axiom label in BFO2 Reference: [124-001]) (forall (x y t) (if (and (occurrentPartOf x y t) (not (= x y))) (exists (z) (and (occurrentPartOf z y t) (not (exists (w) (and (occurrentPartOf w x t) (occurrentPartOf w z t)))))))) // axiom label in BFO2 CLIF: [124-001] (forall (x y t) (if (and (occurrentPartOf x y t) (occurrentPartOf y x t)) (= x y))) // axiom label in BFO2 CLIF: [123-001] (forall (x y t) (if (exists (v) (and (occurrentPartOf v x t) (occurrentPartOf v y t))) (exists (z) (forall (u w) (iff (iff (occurrentPartOf w u t) (and (occurrentPartOf w x t) (occurrentPartOf w y t))) (= z u)))))) // axiom label in BFO2 CLIF: [125-001] (forall (x y z) (if (and (occurrentPartOf x y) (occurrentPartOf y z)) (occurrentPartOf x z))) // axiom label in BFO2 CLIF: [112-001] (forall (x) (if (Occurrent x) (occurrentPartOf x x))) // axiom label in BFO2 CLIF: [113-002] part of occurrent b occurrent_part_of c =Def. b is a part of c & b and c are occurrents. (axiom label in BFO2 Reference: [003-002]) occurrent_part_of is antisymmetric. (axiom label in BFO2 Reference: [123-001]) occurrent_part_of is reflexive (every occurrent entity is an occurrent_part_of itself). (axiom label in BFO2 Reference: [113-002]) occurrent_part_of is transitive. (axiom label in BFO2 Reference: [112-001]) occurrent_part_of satisfies unique product. (axiom label in BFO2 Reference: [125-001]) occurrent_part_of satisfies weak supplementation. (axiom label in BFO2 Reference: [124-001]) (forall (x y t) (if (and (occurrentPartOf x y t) (not (= x y))) (exists (z) (and (occurrentPartOf z y t) (not (exists (w) (and (occurrentPartOf w x t) (occurrentPartOf w z t)))))))) // axiom label in BFO2 CLIF: [124-001] (forall (x y t) (if (and (occurrentPartOf x y t) (occurrentPartOf y x t)) (= x y))) // axiom label in BFO2 CLIF: [123-001] (forall (x y t) (if (exists (v) (and (occurrentPartOf v x t) (occurrentPartOf v y t))) (exists (z) (forall (u w) (iff (iff (occurrentPartOf w u t) (and (occurrentPartOf w x t) (occurrentPartOf w y t))) (= z u)))))) // axiom label in BFO2 CLIF: [125-001] (forall (x y z) (if (and (occurrentPartOf x y) (occurrentPartOf y z)) (occurrentPartOf x z))) // axiom label in BFO2 CLIF: [112-001] (forall (x) (if (Occurrent x) (occurrentPartOf x x))) // axiom label in BFO2 CLIF: [113-002] To say that each spatiotemporal region s temporally_projects_onto some temporal region t is to say that t is the temporal extension of s. (axiom label in BFO2 Reference: [080-003]) To say that spatiotemporal region s spatially_projects_onto spatial region r at t is to say that r is the spatial extent of s at t. (axiom label in BFO2 Reference: [081-003]) To say that each spatiotemporal region s temporally_projects_onto some temporal region t is to say that t is the temporal extension of s. (axiom label in BFO2 Reference: [080-003]) To say that spatiotemporal region s spatially_projects_onto spatial region r at t is to say that r is the spatial extent of s at t. (axiom label in BFO2 Reference: [081-003]) st-projects-onto-s_st projects onto spatial region at some time st-projects-onto-t projects onto temporal region has-participant_at hasParticipantAt Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'has participant at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'has participant@en(x,y,t)'. BFO 2 Reference: Spatial regions do not participate in processes. BFO2 Reference: independent continuant that is not a spatial region, specifically dependent continuant, generically dependent continuant BFO2 Reference: process has_participant is an instance-level relation between a process, a continuant, and a temporal region at which the continuant participates in some way in the process. (axiom label in BFO2 Reference: [086-003]) if b has_participant c at t & c is a generically dependent continuant, then there is some independent continuant that is not a spatial region d, and which is such that c g-depends on d at t & b s-depends_on d at t. (axiom label in BFO2 Reference: [091-003]) if b has_participant c at t & c is a specifically dependent continuant, then there is some independent continuant that is not a spatial region d, c s-depends_on d at t & b s-depends_on d at t. (axiom label in BFO2 Reference: [090-003]) if b has_participant c at t then b is an occurrent. (axiom label in BFO2 Reference: [087-001]) if b has_participant c at t then c exists at t. (axiom label in BFO2 Reference: [089-001]) if b has_participant c at t then c is a continuant. (axiom label in BFO2 Reference: [088-001]) (forall (x y t) (if (and (hasParticipantAt x y t) (GenericallyDependentContinuant y)) (exists (z) (and (IndependentContinuant z) (not (SpatialRegion z)) (genericallyDependsOn y z t) (specificallyDependsOnAt x z t))))) // axiom label in BFO2 CLIF: [091-003] (forall (x y t) (if (and (hasParticipantAt x y t) (SpecificallyDependentContinuant y)) (exists (z) (and (IndependentContinuant z) (not (SpatialRegion z)) (specificallyDependsOnAt x z t) (specificallyDependsOnAt y z t))))) // axiom label in BFO2 CLIF: [090-003] (forall (x y t) (if (hasParticipantAt x y t) (Continuant y))) // axiom label in BFO2 CLIF: [088-001] (forall (x y t) (if (hasParticipantAt x y t) (Occurrent x))) // axiom label in BFO2 CLIF: [087-001] (forall (x y t) (if (hasParticipantAt x y t) (existsAt y t))) // axiom label in BFO2 CLIF: [089-001] has participant at all times has_participant is an instance-level relation between a process, a continuant, and a temporal region at which the continuant participates in some way in the process. (axiom label in BFO2 Reference: [086-003]) if b has_participant c at t & c is a generically dependent continuant, then there is some independent continuant that is not a spatial region d, and which is such that c g-depends on d at t & b s-depends_on d at t. (axiom label in BFO2 Reference: [091-003]) if b has_participant c at t & c is a specifically dependent continuant, then there is some independent continuant that is not a spatial region d, c s-depends_on d at t & b s-depends_on d at t. (axiom label in BFO2 Reference: [090-003]) if b has_participant c at t then b is an occurrent. (axiom label in BFO2 Reference: [087-001]) if b has_participant c at t then c exists at t. (axiom label in BFO2 Reference: [089-001]) if b has_participant c at t then c is a continuant. (axiom label in BFO2 Reference: [088-001]) (forall (x y t) (if (and (hasParticipantAt x y t) (GenericallyDependentContinuant y)) (exists (z) (and (IndependentContinuant z) (not (SpatialRegion z)) (genericallyDependsOn y z t) (specificallyDependsOnAt x z t))))) // axiom label in BFO2 CLIF: [091-003] (forall (x y t) (if (and (hasParticipantAt x y t) (SpecificallyDependentContinuant y)) (exists (z) (and (IndependentContinuant z) (not (SpatialRegion z)) (specificallyDependsOnAt x z t) (specificallyDependsOnAt y z t))))) // axiom label in BFO2 CLIF: [090-003] (forall (x y t) (if (hasParticipantAt x y t) (Continuant y))) // axiom label in BFO2 CLIF: [088-001] (forall (x y t) (if (hasParticipantAt x y t) (Occurrent x))) // axiom label in BFO2 CLIF: [087-001] (forall (x y t) (if (hasParticipantAt x y t) (existsAt y t))) // axiom label in BFO2 CLIF: [089-001] s-depends-on_st specificallyDependsOn A pain s-depends_on the organism that is experiencing the pain a gait s-depends_on the walking object. (All at some specific time.) a shape s-depends_on the shaped object one-sided s-dependence of a dependent continuant on an independent continuant: an instance of headache s-depends_on some head one-sided s-dependence of a dependent continuant on an independent continuant: an instance of temperature s-depends_on some organism one-sided s-dependence of a process on something: a process of cell death s-depends_on a cell one-sided s-dependence of a process on something: an instance of seeing (a relational process) s-depends_on some organism and on some seen entity, which may be an occurrent or a continuant one-sided s-dependence of one occurrent on another: a process of answering a question is dependent on a prior process of asking a question one-sided s-dependence of one occurrent on another: a process of obeying a command is dependent on a prior process of issuing a command one-sided s-dependence of one occurrent on multiple independent continuants: a relational process of hitting a ball with a cricket bat one-sided s-dependence of one occurrent on multiple independent continuants: a relational process of paying cash to a merchant in exchange for a bag of figs reciprocal s-dependence between occurrents: a process of buying and the associated process of selling reciprocal s-dependence between occurrents: a process of increasing the volume of a portion of gas while temperature remains constant and the associated process of decreasing the pressure exerted by the gas reciprocal s-dependence between occurrents: in a game of chess the process of playing with the white pieces is mutually dependent on the process of playing with the black pieces the one-sided dependence of an occurrent on an independent continuant: football match on the players, the ground, the ball the one-sided dependence of an occurrent on an independent continuant: handwave on a hand the three-sided reciprocal s-dependence of the hue, saturation and brightness of a color [45 the three-sided reciprocal s-dependence of the pitch, timbre and volume of a tone [45 the two-sided reciprocal s-dependence of the roles of husband and wife [20 Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'specifically depends on at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'specifically depends on@en'(x,y,t) BFO 2 Reference: An entity – for example an act of communication or a game of football – can s-depends_on more than one entity. Complex phenomena for example in the psychological and social realms (such as inferring, commanding and requesting) or in the realm of multi-organismal biological processes (such as infection and resistance), will involve multiple families of dependence relations, involving both continuants and occurrents [1, 4, 28 BFO 2 Reference: S-dependence is just one type of dependence among many; it is what, in the literature, is referred to as ‘existential dependence’ [87, 46, 65, 20 BFO 2 Reference: the relation of s-depends_on does not in every case require simultaneous existence of its relata. Note the difference between such cases and the cases of continuant universals defined historically: the act of answering depends existentially on the prior act of questioning; the human being who was baptized or who answered a question does not himself depend existentially on the prior act of baptism or answering. He would still exist even if these acts had never taken place. BFO2 Reference: specifically dependent continuant\; process; process boundary To say that b s-depends_on a at t is to say that b and c do not share common parts & b is of its nature such that it cannot exist unless c exists & b is not a boundary of c and b is not a site of which c is the host [64 If b is s-depends_on something at some time, then b is not a material entity. (axiom label in BFO2 Reference: [052-001]) If b s-depends_on something at t, then there is some c, which is an independent continuant and not a spatial region, such that b s-depends_on c at t. (axiom label in BFO2 Reference: [136-001]) If occurrent b s-depends_on some independent continuant c at t, then b s-depends_on c at every time at which b exists. (axiom label in BFO2 Reference: [015-002]) an entity does not s-depend_on any of its (continuant or occurrent) parts or on anything it is part of. (axiom label in BFO2 Reference: [013-002]) if b s-depends_on c at t & c s-depends_on d at t then b s-depends_on d at t. (axiom label in BFO2 Reference: [054-002]) (forall (x y t) (if (and (Entity x) (or (continuantPartOfAt y x t) (continuantPartOfAt x y t) (occurrentPartOf x y) (occurrentPartOf y x))) (not (specificallyDependsOnAt x y t)))) // axiom label in BFO2 CLIF: [013-002] (forall (x y t) (if (and (Occurrent x) (IndependentContinuant y) (specificallyDependsOnAt x y t)) (forall (t_1) (if (existsAt x t_1) (specificallyDependsOnAt x y t_1))))) // axiom label in BFO2 CLIF: [015-002] (forall (x y t) (if (specificallyDependsOnAt x y t) (exists (z) (and (IndependentContinuant z) (not (SpatialRegion z)) (specificallyDependsOnAt x z t))))) // axiom label in BFO2 CLIF: [136-001] (forall (x y z t) (if (and (specificallyDependsOnAt x y t) (specificallyDependsOnAt y z t)) (specificallyDependsOnAt x z t))) // axiom label in BFO2 CLIF: [054-002] (forall (x) (if (exists (y t) (specificallyDependsOnAt x y t)) (not (MaterialEntity x)))) // axiom label in BFO2 CLIF: [052-001] specifically depends on at some time If b is s-depends_on something at some time, then b is not a material entity. (axiom label in BFO2 Reference: [052-001]) If b s-depends_on something at t, then there is some c, which is an independent continuant and not a spatial region, such that b s-depends_on c at t. (axiom label in BFO2 Reference: [136-001]) If occurrent b s-depends_on some independent continuant c at t, then b s-depends_on c at every time at which b exists. (axiom label in BFO2 Reference: [015-002]) an entity does not s-depend_on any of its (continuant or occurrent) parts or on anything it is part of. (axiom label in BFO2 Reference: [013-002]) if b s-depends_on c at t & c s-depends_on d at t then b s-depends_on d at t. (axiom label in BFO2 Reference: [054-002]) (forall (x y t) (if (and (Entity x) (or (continuantPartOfAt y x t) (continuantPartOfAt x y t) (occurrentPartOf x y) (occurrentPartOf y x))) (not (specificallyDependsOnAt x y t)))) // axiom label in BFO2 CLIF: [013-002] (forall (x y t) (if (and (Occurrent x) (IndependentContinuant y) (specificallyDependsOnAt x y t)) (forall (t_1) (if (existsAt x t_1) (specificallyDependsOnAt x y t_1))))) // axiom label in BFO2 CLIF: [015-002] (forall (x y t) (if (specificallyDependsOnAt x y t) (exists (z) (and (IndependentContinuant z) (not (SpatialRegion z)) (specificallyDependsOnAt x z t))))) // axiom label in BFO2 CLIF: [136-001] (forall (x y z t) (if (and (specificallyDependsOnAt x y t) (specificallyDependsOnAt y z t)) (specificallyDependsOnAt x z t))) // axiom label in BFO2 CLIF: [054-002] (forall (x) (if (exists (y t) (specificallyDependsOnAt x y t)) (not (MaterialEntity x)))) // axiom label in BFO2 CLIF: [052-001] history-of historyOf [copied from inverse property 'has history'] b has_history c iff c history_of b [XXX-001 b history_of c if c is a material entity or site and b is a history that is the unique history of cAxiom: if b history_of c and b history_of d then c=d [XXX-001 history of Adrien Barton Arnaud Rosier Jean-François Ethier Paul Fabry http://creativecommons.org/licenses/by/4.0/ Cardio Vascular Disease Ontology CVDO is an ontology of cardiovascular diseases structured on OBO foundry’s principle and based on BFO. CVDO reorganizes and completes DOID cardiovascular diseases following OGMS tripartite model of disease, and builds its taxonomy of diseases largely by automatic reasoning. 2024-05-17 PlainLiteral label